WorldWideScience

Sample records for pre-trial detainees combined

  1. ICE Online Detainee Locator System

    Data.gov (United States)

    Department of Homeland Security — The Online Detainee Locator datasets provide the location of a detainee who is currently in ICE custody, or who was release from ICE custody for any reason with the...

  2. Euthanasia for Detainees in Belgium.

    Science.gov (United States)

    Devolder, Katrien

    2016-07-01

    In 2011, Frank Van Den Bleeken became the first detainee to request euthanasia under Belgium's Euthanasia Act of 2002. This article investigates whether it would be lawful and morally permissible for a doctor to accede to this request. Though Van Den Bleeken has not been held accountable for the crimes he committed, he has been detained in an ordinary prison, without appropriate psychiatric care, for more than 30 years. It is first established that Van Den Bleeken's euthanasia request plausibly meets the relevant conditions of the Euthanasia Act and that, consequently, a doctor could lawfully fulfill it. Next, it is argued that autonomy-based reasons for euthanizing him outweigh complicity-based reasons against doing so, and that, therefore, it is also morally permissible for a doctor to carry out the euthanasia request.

  3. [Suicide and suicide tendencies in adolescent detainees].

    Science.gov (United States)

    Radeloff, Daniel; Lempp, Thomas; Rauf, Amna; Bennefeld-Kersten, Katharina; Kettner, Mattias; Freitag, Christine M

    2016-01-01

    Following accidents, suicide is the second leading cause of death in adolescence. This stage of life has the most suicide attempts of all age groups. In addition to mentally ill juveniles, adolescent delinquents represent a high-risk group for suicidal behavior and completed suicide. In particular, the population of detainees, an extreme form of juvenile delinquency, have a 16- to 18-fold higher risk of suicidal behavior and suicide compared to the general population. Because the composition of juvenile detainees differs greatly from that of detained adults, age-specific scientific approaches and prevention programs are needed. This task cannot be addressed by juvenile detention staff alone, but rather demands close cooperation between adolescent psychiatrists, psychologists, prison medical staff, legal experts and prison officers to use the opportunity for suicide prevention in juvenile detention facilities.

  4. Treatment of Battlefield Detainees in the War on Terrorism

    National Research Council Canada - National Science Library

    Elsea, Jennifer

    2005-01-01

    .... court has jurisdiction to hear petitions for habeas corpus on behalf of the detainees because they are aliens detained abroad, but left questions involving prisoners rights and status unanswered...

  5. Treatment of 'Battlefield Detainees' in the War on Terrorism

    National Research Council Canada - National Science Library

    Elsea, Jennifer K

    2007-01-01

    .... court has jurisdiction to hear petitions for habeas corpus on behalf of the detainees because they are aliens detained abroad, but left questions involving prisoners rights and status unanswered...

  6. Treatment of "Battlefield Detainees" in the War on Terrorism

    National Research Council Canada - National Science Library

    Elsea, Jennifer K

    2006-01-01

    .... court has jurisdiction to hear petitions for habeas corpus on behalf of the detainees because they are aliens detained abroad, but left questions involving prisoners rights and status unanswered...

  7. Treatment of "Battlefield Detainees" in the War on Terrorism

    National Research Council Canada - National Science Library

    Elsea, Jennifer

    2005-01-01

    .... court has jurisdiction to hear petitions for habeas corpus on behalf of the detainees because they are aliens detained abroad, but left questions involving prisoners' rights and status unanswered...

  8. Treatment of "Battlefield Detainees" in the War on Terrorism

    National Research Council Canada - National Science Library

    Elsea, Jennifer K

    2006-01-01

    .... court has jurisdiction to hear petitions for "habeas corpus" on behalf of the detainees because they are aliens detained abroad, but left questions involving prisoners' rights and status unanswered...

  9. An Ethical Framework for Physician Involvement in Detainee Interrogations

    Science.gov (United States)

    2006-03-15

    procedures to otherwise able-bodied human beings (i.e. cosmetic (vs. reconstructive) surgeries , bariatric intestinal redirecting surgeries , diet pills...process. The purpose should only be to ensure that the dignity of the detainee is not being violated and that interrogation techniques protect that...obtain information from patients or assist in the detainee management. a. Training and advising interrogators in interview techniques .43, 44 b. Observing

  10. Relocate GTMO Detainees to Stand Trial in the United States

    Science.gov (United States)

    2011-03-16

    the 1998 terrorist bombings of the United States Embassies in Nairobi, Kenya, and Dar es Salaam , Tanzania. Expect...St ra te gy R es ea rc h Pr oj ec t RELOCATE GTMO DETAINEES TO STAND TRIAL IN THE UNITED STATES BY LIEUTENANT COLONEL REX D. LYNNE...options for the disposition of Guantanamo detainees and others captured by the United States.2 On 20 May 2009, in a bi-partisan vote, Congress denied the

  11. "Six Floors" of Detainee Operations in the Post 9/11 World

    National Research Council Canada - National Science Library

    Ayres, Thomas E

    2005-01-01

    There are persuasive legal, ethical and practical reasons for clarifying categories of detainees and improving guidance to those conducting detainee and interrogation operations in the post-9/11 environment...

  12. Reported assaults and observed injuries in detainees held in police custody.

    Science.gov (United States)

    Gahide, Sophie; Lepresle, Aude; Boraud, Cyril; Mahindhoratep, Tiao S; Chariot, Patrick

    2012-11-30

    The deprivation of liberty in police custody can be associated with violent situations and traumatic injuries. The rare available data did not mention whether alleged assaults occurred at the time of the arrest or during custody. Our objectives were to describe the frequency of recent traumatic injuries observed in detainees at the time of medical examination and to record detainees' self-reports of received physical violence, either before being arrested, at the time of the arrest, or during custody. In 2694 consecutive detainees examined in a suburban area near Paris, we compared persons' characteristics in four groups, according to the existence of alleged assaults or the presence of recent traumatic injuries, or both. Detainees reported to be victims of physical assaults in 25% of cases (686 of 2694): 374 assaults of 686 (55%) occurred at the time of arrest and 87 of 686 (13%) during custody. The opinion of assaulted detainees on custody was worse than non-assaulted detainees. Detainees alleging assaults by the police, whatever the time of the assault, accounted for 396 cases (15%). Three quarters of detainees (547 of 686, 79%) alleging assaults had recent traumatic injuries. When we considered all detainees, medical examination showed recent traumatic injuries in 724 of 2694 (27%). Injured detainees were declared unfit for detention more frequently than non-injured non-assaulted detainees (Pcustody. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  13. Detainees in police custody: results of a health needs assessment in Northumbria, England.

    Science.gov (United States)

    Sirdifield, Coral; Brooker, Charlie

    2012-01-01

    The purpose of this paper is to assess the health needs of detainees in police custody in Northumbria, England, and to identify any gaps in, or possible improvements to, the current model of healthcare provision. The current model of service provision was investigated using a combination of existing literature, and interviews with key members of staff. In addition, researchers examined the custody records of a stratified random sample of 1,917 records from 2010 and 2011. Data were collected from the risk assessments completed by Custody Sergeants, and any associated records of medical assessments by Forensic Medical Examiners (FME). Detainees experience a wide range of health problems. Delivery of healthcare in custody could be improved through increasing the skill-mix in this setting, computerising FME records and improving communication between agencies. Research limitations/implications - The police did not always record the reason why a forensic medical examiner was called out, thus this aspect of data collection was limited. This health needs assessment will help to determine the way in which resources for health care in custody, currently held by the police, are reallocated once the funding transfers to the NHS in the near future.

  14. 48 CFR 252.237-7019 - Training for Contractor Personnel Interacting with Detainees.

    Science.gov (United States)

    2010-10-01

    ... located will arrange for training to be provided to contractor personnel interacting with detainees. The training will address the international obligations and laws of the United States applicable to the... if, for compelling reasons, the Contracting Officer authorizes interaction with detainees prior to...

  15. Serological Susceptibility to Varicella Among U.S. Immigration and Customs Enforcement Detainees.

    Science.gov (United States)

    Varan, Aiden K; Lederman, Edith R; Stous, Shanon S; Elson, Diana; Freiman, Jennifer L; Marin, Mona; Lopez, Adriana S; Stauffer, William M; Joseph, Rachael H; Waterman, Stephen H

    2018-01-01

    U.S. Immigration and Customs Enforcement (ICE) is responsible for detaining unauthorized aliens during immigration proceedings. During 2014 to 2015, adult ICE detainees at a California facility were invited to complete a survey concerning self-reported varicella history and risk factors. Participants underwent serological testing for varicella-zoster virus (VZV) IgG; susceptible individuals were offered varicella vaccination. Among 400 detainees with available serology results, 48 (12%) were susceptible to varicella. Self-reported varicella history was negatively associated with susceptibility (adjusted odds ratio = 0.16; 95% confidence interval [0.07, 0.35]). Among 196 detainees reporting a positive history, 95% had VZV IgG levels suggestive of varicella immunity. Among 44 susceptible detainees offered vaccination, 86% accepted. Given relatively high varicella susceptibility, targeted screening and vaccination among ICE detainees lacking a positive history might reduce varicella transmission risks.

  16. Health Service Support for Detainees in Maritime Security Operations: What Is Required and What Is Right?

    National Research Council Canada - National Science Library

    McDonald, Brian R

    2005-01-01

    ... U.S. and Coalition personnel, but also for potential detainees. The range of HSS may vary from oversight of routine health and sanitation visits to the provision of afloat trauma care in the event of wounding or serious injury...

  17. Jail detainee allowed to sue using pseudonym, Judge says.

    Science.gov (United States)

    1999-04-16

    U.S. District Judge Myron L. Gordon granted an HIV-positive plaintiff's request to be allowed to use a pseudonym in litigation against the City of Milwaukee because of the stigma still associated with AIDS. "John Roe" as the plaintiff is called, says when he was detained by the Milwaukee police, his HIV status was posted on his cell. The sign was in place for 3 hours, plainly visible to detainees and visitors. Although the booking officer told "Roe" it was a reminder to sanitize the cell, "Roe" alleges that this violated his constitutional rights and was caused by the city's failure to supervise and train its employees. The city did not oppose the motion, but objected to the plaintiff's request for a protective order, which would seal the documents containing his real name.

  18. The Mental Health Sequelae of Traumatic Head Injury in South Vietnamese Ex-Political Detainees Who Survived Torture

    Science.gov (United States)

    Mollica, Richard F.; Chernoff, Miriam C.; Berthold, S. Megan; Lavelle, James; Lyoo, In Kyoon; Renshaw, Perry

    2014-01-01

    Little is known about the relationship between traumatic head injury (THI) and psychiatric morbidity in torture survivors. We examine the relationship between THI and depression, PTSD, post-concussive syndrome (PCS), disability and poor health status in Vietnamese ex-political detainees who survived incarceration in Vietnamese re-education camps. A community sample of ex-political detainees (n=337) and a non-THI, non-ex-detainee comparison group (n=82) were surveyed. 78% of the ex-political detainees had experienced THI. 90.6% of the ex-political detainees and 3.6% of the comparison group had experienced 7 or more trauma events. Depression and PTSD were greater in ex-detainees than the comparison group (40.9% vs 23.2% and 13.4% vs 0%). Dose-effect relationships for THI and trauma/torture in the ex-political detainee group were significant. Logistic regression in the pooled sample of ex-detainees and the comparison group confirmed the independent impact of THI from trauma/torture on psychiatric morbidity (OR for PTSD=22.4; 95% CI: 3.0-165.8). These results demonstrate important effects of THI on depression and PTSD in Vietnamese ex-detainees who have survived torture. PMID:24962448

  19. Commentary (Pre-Trial Detention in the Extraordinary Chambers in the Courts of Cambodia )

    DEFF Research Database (Denmark)

    Marchuk, Iryna

    2015-01-01

    Most international criminal courts and tribunals find provisional detention absolutely necessary to ensure the swift delivery of justice. A decision on pre-trial detention must be in conformity with well-recognized human rights standards, thus respecting the person’s right to a fair trial...

  20. DETOUR - Towards Pre-trial Detention as Ultima Ratio : 2nd Dutch National Report on Expert Interviews

    NARCIS (Netherlands)

    Boone, M.M.; Lindeman, J.M.W.; Jacobs, P.

    This national report is created within a European research project, commissioned by the Europe-an Commission, with the title ‘DETOUR – Towards Pre-trial Detention as Ultima Ratio’ that was conducted in 2016-2017. The research project aimed at exploring and analysing pre-trial detention practice,

  1. The Combination of Pixantrone, Etoposide, Bendamustine and, in CD20+ Tumors, Rituximab (PREBEN) Shows Promising Feasibility/Efficacy in Heavily Pre-Treated Aggressive Lymphomas of B- and T-Cell Phenotype - Results of the Pre-Trial Experience Leading to a Nordic Phase 1/2 Study (the PREBEN Trial)

    DEFF Research Database (Denmark)

    Clausen, Michael Roost; Leppa, Sirpa; Brown, Peter de Nully

    2016-01-01

    Background: Aggressive non-Hodgkin lymphoma (aNHL) relapsing after high-dose therapy or, in not transplant-eligible patients, after 1st-line chemotherapy represents an unmet clinical need. Therefore, we aimed at evaluating a salvage combination regimen based on pixantrone, an aza-anthracenadione ......Background: Aggressive non-Hodgkin lymphoma (aNHL) relapsing after high-dose therapy or, in not transplant-eligible patients, after 1st-line chemotherapy represents an unmet clinical need. Therefore, we aimed at evaluating a salvage combination regimen based on pixantrone, an aza......IND developed acute myeloid leukemia with therapy-related cytogenetic features.Conclusions: The PREBEN/PEBEN salvage regimen was feasible in a heavily pre-treated cohort of elderly patients with high-risk aNHL. In individual patients it elicited substantial and durable responses early in the course of therapy...

  2. Comorbidities and correlates of conduct disorder among male juvenile detainees in South Korea.

    Science.gov (United States)

    Choi, Bum-Sung; Kim, Johanna Inhyang; Kim, Bung-Nyun; Kim, Bongseog

    2017-01-01

    The purpose of this study was to examine the rate and distribution of comorbidities, severity of childhood maltreatment, and clinical characteristics of adolescents with conduct disorder detained in a juvenile detention center in South Korea. In total, 173 juvenile detainees were recruited. We analyzed the distribution of psychiatric disorders among the sample and compared the rate of comorbidities between groups with and without conduct disorder. We compared the two groups in terms of demographic and clinical characteristics, as well as severity of childhood maltreatment and psychiatric problems, using the Young Self Report (YSR) scale. A total of 95 (55%) of the detainees were diagnosed with conduct disorder, and 93 (96.9%) of them had at least one comorbid axis I psychiatric disorder. Detainees with conduct disorder had a higher number of comorbid psychiatric disorders; a higher rate of violent crime perpetration; had suffered more physical, emotional, and sexual abuse; and showed higher total YSR scores and externalizing behavior, somatic complaints, rule-breaking behavior, and aggressive behavior YSR subscale scores. Conduct disorder is a common psychiatric disorder among juvenile detainees in South Korea, who tend to commit more violent crimes and show more psychopathology than detainees who do not have conduct disorder. These findings highlight the importance of diagnosing and intervening in conduct disorder within the juvenile detention system.

  3. Commentary (Pre-Trial Detention in the Extraordinary Chambers in the Courts of Cambodia )

    DEFF Research Database (Denmark)

    Marchuk, Iryna

    2015-01-01

    Most international criminal courts and tribunals find provisional detention absolutely necessary to ensure the swift delivery of justice. A decision on pre-trial detention must be in conformity with well-recognized human rights standards, thus respecting the person’s right to a fair trial...... with international human rights standards and exposes serious deficiencies of judicial reasoning in selected decisions of the Court....

  4. Defendant’s free will in legal collaboration and its relation with pre-trial detention

    Directory of Open Access Journals (Sweden)

    Antonio Henrique Graciano Suxberger

    2017-03-01

    Full Text Available The legal collaboration, a type of evidence used on organized crime prosecutions, demands free will of the defendant. Appraising the defendant’s free will, many critics cover the deals made with an arrested defendant during the negotiation of the legal collaboration. These two institutes — legal collaboration and pre-trial detention —, although they do not present themselves as a cause-effect relation, commonly are approached in practice as associated. This essay intends to evaluate the defendant’s free will during pre-trial detention and the legal collaboration’s bargaining. It asserts a strict and clear relation between pre-trial detention and the legal collaboration bargaining. Identifying occasional problems do not imply the conclusion on the existence of a structural problem to legal collaboration institute. This consideration is relevant to avoid superficial solutions that could fragilize even more the held defendant. Methodologically, from a literature review and document analysis about the subject, the paper clarifies what is a “criminal case” and what it means to the study.

  5. 76 FR 44282 - Defense Federal Acquisition Regulation Supplement; Prohibition on Interrogation of Detainees by...

    Science.gov (United States)

    2011-07-25

    ...-AG88 Defense Federal Acquisition Regulation Supplement; Prohibition on Interrogation of Detainees by.... It also allows the Secretary of Defense to waive the prohibition for a limited period of time, with... Defense to waive the prohibition on contractor interrogations for up to 60 days on the grounds of national...

  6. Use of Royal Darwin Hospital emergency department by immigration detainees in 2011.

    Science.gov (United States)

    Deans, Adrienne K; Boerma, Clare J; Fordyce, James; De Souza, Mark; Palmer, Didier J; Davis, Joshua S

    2013-12-16

    To describe the number and nature of emergency department (ED) attendances by immigration detainees in Darwin, in the Northern Territory, over a 12-month period. Retrospective observational study of immigration detainees attending the Royal Darwin Hospital ED during the 2011 calendar year. Number of ED attendances and primary diagnoses. In 2011, there were 770 ED attendances by 518 individual detainees at Royal Darwin Hospital. Those who attended the ED had a mean (SD) age of 27.6 (12.2) years, and 112 of them (21.6%) were children. Most (413, 79.7%) were male, and Iran and Afghanistan were the two most common countries of birth. We estimate that 50.1% (95% CI, 47.0%-53.2%) of immigration detainees in Darwin (mean, 776 per month; total, 1034), attended the Royal Darwin Hospital ED at least once in 2011. The most common primary diagnosis was psychiatric problems (187 attendances, 24.3%), including self-harm (138 attendances, 17.9%). In 2011, asylum seekers in immigration detention in Darwin had a high prevalence of unmet health needs and substantial levels of psychiatric morbidity. The primary health care provided to them was inadequate.

  7. Health-care issues and health-care use among detainees in police custody.

    NARCIS (Netherlands)

    Ceelen, M.; Dorn, T.; Buster, M.; Stirbu, I.; Donker, G.; Das, K.

    2012-01-01

    Epidemiological research on the physical health status of police detainees is scarce. The present study fills this gap by first studying the somatic reasons for consultation (n = 4396) and related prescriptions (n = 4912) as assessed by the forensic medical service during police detainment.

  8. Mental health and health-care use of detainees in police custody.

    NARCIS (Netherlands)

    Dorn, T.; Ceelen, M.; Buster, M.; Stirbu, I.; Donker, G.; Das, K.

    2014-01-01

    Background: In many countries, forensic physicians function as primary care providers for detainees in police custody. Their task is comparable to the tasks of general practitioners. Nevertheless, problems presented by both patient populations may differ. We therefore aimed to systematically compare

  9. Police custody detainees and forensic medicine: Medical consumption in the cellblock

    NARCIS (Netherlands)

    Blaauw, E.; Lulf, R.

    1999-01-01

    Various Dutch reports show that medical usage among those detained in police cells is many times higher than among the average population. Many visits by forensic physicians (some 36%) are due to the fact that many police custody detainees are addicted. Also, many visits are carried out as a result

  10. Health problems among detainees in Switzerland: a study using the ICPC-2 classification

    Directory of Open Access Journals (Sweden)

    Bertrand Dominique

    2011-04-01

    Full Text Available Abstract Background Little is known about the health status of prisoners in Switzerland. The aim of this study was to provide a detailed description of the health problems presented by detainees in Switzerland's largest remand prison. Methods In this retrospective cross-sectional study we reviewed the health records of all detainees leaving Switzerland's largest remand prison in 2007. The health problems were coded using the International Classification for Primary Care (ICPC-2. Analyses were descriptive, stratified by gender. Results A total of 2195 health records were reviewed. Mean age was 29.5 years (SD 9.5; 95% were male; 87.8% were migrants. Mean length of stay was 80 days (SD 160. Illicit drug use (40.2% and mental health problems (32.6% were frequent, but most of these detainees (57.6% had more generic primary care problems, such as skin (27.0%, infectious diseases (23.5%, musculoskeletal (19.2%, injury related (18.3%, digestive (15.0% or respiratory problems (14.0%. Furthermore, 7.9% reported exposure to violence during arrest by the police. Conclusion Morbidity is high in this young, predominantly male population of detainees, in particular in relation to substance abuse. Other health problems more commonly seen in general practice are also frequent. These findings support the further development of coordinated primary care and mental health services within detention centers.

  11. 75 FR 67632 - Defense Federal Acquisition Regulation Supplement; Prohibition on Interrogation of Detainees by...

    Science.gov (United States)

    2010-11-03

    ...D Instruction 1100.22, Policy and Procedures for Determining Workforce Mix ( http://www.dtic.mil/whs... ( http://www.dtic.mil/whs/directives/corres/pdf/231001p.pdf ); and DoD Directive 3115.09, DoD Intelligence Interrogations, Detainee Debriefings, and Tactical Questioning ( http://www.dtic.mil/whs...

  12. Representing Immigration Detainees: The Juxtaposition of Image and Sound in "Border Country"

    Directory of Open Access Journals (Sweden)

    Melanie Friend

    2010-05-01

    Full Text Available This paper discusses the four-year (2003-2007 research process towards my exhibition and publication "Border Country", which focuses on the experience of immigration detainees (appellant or "failed" asylum seekers in the UK's "immigration removal centres". I discuss my earlier exhibition "Homes and Gardens: Documenting the Invisible" which focused on the repression in Kosovo under the Milošević regime, and the difficulties of representing the "hidden violence" which led to the adoption of a particular sound/image structure for the exhibition. I discuss how I then chose to work with a similar sound/image framework for "Border Country" and the aesthetic and conceptual considerations involved. I discuss the decision to expand the focus of the exhibition from one individual detainee to eleven, and to omit the photographic portraits of detainees from the exhibition for ethical and conceptual reasons. I finally produced a juxtaposition of photographs of immigration removal centre landscapes and interiors (devoid of people with a soundtrack of oral testimonies. The voices of individual detainees could be heard at listening stations within the gallery spaces or on the publication's audio CD. Within this research process I also discuss my interview methodology and questions of power imbalance between photographer/artist and incarcerated asylum seekers. URN: urn:nbn:de:0114-fqs1002334

  13. Pre-trial agreement and plea bargain: pragmatism without conflict with morality?

    Directory of Open Access Journals (Sweden)

    Rodin V.V.

    2014-12-01

    Full Text Available A comparative legal analysis of plea bargain in the continental Europe, England and the USA is conducted. The history of the plea bargain emergence in common law is examined, its features are shown. Such agreements to plead guilty are often reached after bringing a charge. The freedom of agreement is guaranteed by the powers of police, court and public prosecutor to decide on the severity of the charge, its change or dismissal (partial or complete. An obvious “conflict of interests” is shown: the economic benefit of plea agreement is complicated by ignoring the public morality principles. It doesn’t allow to use the same form of plea bargain in the Russian realities: the essence of the pre-trial agreement institute doesn’t imply that the defendant pleads guilty, but contributes to solving a crime (disclosure of information about accomplices, compensation for damage. The proposals to improve the regulation of the Russian pre-trial cooperation agreement are made. The foreign models of plea bargain are studied: German, French, Spanish, Italian and Portuguese. Their comparison allows to conclude that such deal can be used in different national legal systems and in various models of criminal procedure. It’s argued that the institution of pre-trial agreement is the objective response of the Russian law enforcement bodies to modern challenges. American model of plea bargain can be considered optimal despite its shortcomings. Other states don’t accept it unchanged. Russia also has to transform the western model of plea bargain, taking into account the requirements of the domestic legal culture.

  14. Optimization of Pre-Trial Proceedings in Multi-Disciplinary Criminal Cases

    Directory of Open Access Journals (Sweden)

    Irina S. Smirnova

    2017-05-01

    Full Text Available The article is devoted to determining the factors affecting the value of expenditures for pre-trial proceedings in the multi-subject (complicated criminal cases. As a preliminary investigation of the criminal cases in this category facing difficulties criminal law, criminalistics, investigative, organizational and criminal procedure character, extent increase the financial costs of production in such cases. Identified and justified of the necessity of recognition of such factors constant over-spending in the amount of variable costs multiplied by the number of accused and the number of crimes in each specific criminal case.

  15. CTC Sentinel. Volume 1, Issue 12, November 2008. The Dilemma of the Yemeni Detainees at Guantanamo Bay

    National Research Council Canada - National Science Library

    Johnsen, Gregory D; Boucek, Christopher

    2008-01-01

    .... Other countries, most notably Saudi Arabia, have successfully repatriated many of their nationals, but Yemen has been unable to convince the United States to release detainees into its custody...

  16. Indefinite Detention / Enduring Freedom: What Former Detainees' Experiences Can Teach Us About Institutional Violence, Resistance and the Law

    OpenAIRE

    Koenig, Kimberly Alexa

    2013-01-01

    This dissertation focuses on the experiences of former Guantánamo detainees as communicated in 78 interviews. An analysis of those interviews centers on former detainees' worst experiences to parse how those experiences might inform society's understanding of cruel, inhuman and degrading treatment. The dissertation is organized into nine chapters.Chapter one situates this study in the context of the United States' response to the events of 9/11, with an emphasis on the imprisonment of indivi...

  17. Physical restraint and the protection of the human rights of immigration detainees in hospitals.

    Science.gov (United States)

    Pickles, Hilary; Norton, Emma; Ginn, Emma; Schleicher, Theresa

    2015-08-01

    Immigration detainees, like prisoners, are entitled to the same standard of healthcare as non-detained patients. When hospital attendance or admission is required, the priority for custodial staff (who for purposes of this article we refer to as 'escorts') is to prevent absconding. For that reason, they may wish to use physical restraints, such as handcuffs, and remain with the detainee at all times. This can be degrading for the patient and breach their human rights. Clinicians have professional obligations to all their patients and must object to any restraint methods that risk damaging the patient's right to confidentiality, treatment, health or the therapeutic relationship itself. The starting presumption is that restraints ought not to be used during treatment and only in the most exceptional cases ought escorts to be present during clinical examination or treatment. © Royal College of Physicians 2015. All rights reserved.

  18. Detainee Healthcare in Theater Hospitals: Are Air Force Medics Prepared for the Challenge

    Science.gov (United States)

    2009-04-01

    detainee then yelled in anger that the blood of an infidel was on him and demanded new cloths. 57 In another such incident, a Navy medic was severely...bunch of stuff to read. The Koran was important, as was the Manchester document. I also read some psychology journal articles on treating Muslims...Sustainment of Trauma and Readiness Skills (C-STARS), Self Aid-Buddy Care, Medical Unit Readiness Training (MURT), Unit Type Code (UTC) training, Just

  19. Are the American Psychological Association?s Detainee Interrogation Policies Ethical and Effective?

    OpenAIRE

    Pope, Kenneth S.

    2011-01-01

    After 9?11, the United States began interrogating detainees at settings such as Abu Ghraib, Bagram, and Guantanamo. The American Psychological Association (APA) supported psychologists? involvement in interrogations, adopted formal policies, and made an array of public assurances. This article?s purpose is to highlight key APA decisions, policies, procedures, documents, and public statements in urgent need of rethinking and to suggest questions that may be useful in a serious assessment, such...

  20. Cannabis use in a Swiss male prison: qualitative study exploring detainees' and staffs' perspectives.

    Science.gov (United States)

    Ritter, Catherine; Broers, Barbara; Elger, Bernice S

    2013-11-01

    Several studies suggest a high prevalence of cannabis use before and during imprisonment, but subjective perspectives of detainees and staff towards its use in prison are lacking. This issue was explored in the framework of an observational study addressing tobacco use in three Swiss prisons in 2009 and 2010 that involved multiple strands (quantitative and qualitative components). This article presents qualitative data on cannabis use collected in one of the settings. We used in-depth semi-structured interviews with both detainees and staff to explore their attitudes towards cannabis in one post-trial male Swiss prison. We performed specific coding and thematic analysis for cannabis with the support of ATLAS.ti, compared detainees' and staff's opinions, and considered the results with regard to drug policy in prison in general. 58 participants (31 male offenders, mean age 35 years, and 27 prison staff, mean age 46 years, 33% female) were interviewed. Detainees estimated the current use of cannabis use to be as high as 80%, and staff 50%. Participants showed similar opinions on effects of cannabis use that were described both at individual and institutional levels: analgesic, calming, self-help to go through the prison experience, relieve stress, facilitate sleep, prevent violence, and social pacifier. They also mentioned negative consequences of cannabis use (sleepiness, decreased perception of danger and social isolation), and dissatisfaction regarding the ongoing ambiguous situation where cannabis is forbidden but detection in the urine was not sanctioned. However, the introduction of a more restrictive regulation induced fear of violence, increased trafficking and a shift to other drug use. Although illegal, cannabis use is clearly involved in daily life in prison. A clearer and comprehensive policy addressing cannabis is needed, including appropriate measures tailored to individual users. To sustain a calm and safe environment in prison, means other than

  1. When the War Doesn’t End: Detainees in Legal Limbo

    Science.gov (United States)

    2014-05-01

    Condoleezza Rice for an apology for his detention.18 The German chancellor raised the issue again with President Bush in 2006.19 While these meetings...34 Ex-detainee suit overshadows Rice -Merkel visit," Dec. 6, 2005. 19 Knowlton, Brian, "Merkel and Bush in ’spirited’ and friendly talks", The New...newsvl.orf.at/ticker/215755.html, last viewed March 13, 2014; Beer , Angelika "Europaisches Parlament fordert Schliegung von Guantanamo", Jan. 18, 2005; "Anna

  2. Alcohol and substance screening and brief intervention for detainees kept in police custody. A feasibility study.

    Science.gov (United States)

    Chariot, Patrick; Lepresle, Aude; Lefèvre, Thomas; Boraud, Cyril; Barthès, Agnès; Tedlaouti, Menouar

    2014-01-01

    Screening and brief intervention programs related to addictive disorders have proven effective in a variety of environments. Both the feasibility and outcome of brief interventions performed in police custody by forensic physicians are unknown. Our objectives were to characterize addictive behaviors in detainees and to evaluate the feasibility of a brief intervention at the time of the medical examination in police custody. This prospective study included 1000 detainees in police custody who were examined by a physician for the assessment of fitness for detention. We used a standardized questionnaire and collected data concerning individual characteristics, addictive disorders, and reported assaults or observed injuries. 944 men and 56 women (94-6%) were studied. We found an addictive disorder in 708 of 1000 cases (71%), with the use of tobacco (62%), alcohol (36%), cannabis (35%), opiates (5%), and cocaine (4%) being the most common. A brief intervention was performed in 544 of these 708 cases (77%). A total of 139 of the 708 individuals (20%) expressed a willingness to change and 14 of 708 (2%) requested some information on treatment options. The main reasons why brief interventions were not performed were aggressive behaviors, drowsiness, or fanciful statements by the detainee. Brief interventions and screening for addictive behaviors in police custody are feasible in the majority of cases. The frequent link between addictive behaviors and the suspected crimes highlights the value of such interventions, which could be incorporated into the public health mission of the physician in police custody. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  3. Mass administration of the antimalarial drug mefloquine to Guantánamo detainees: a critical analysis.

    Science.gov (United States)

    Nevin, Remington L

    2012-10-01

    Recently, evidence has emerged from an unusual form of mass drug administration practised among detainees held at US Naval Station Guantánamo Bay, Cuba ('Guantánamo'), ostensibly as a public health measure. Mefloquine, an antimalarial drug originally developed by the US military, whose use is associated with a range of severe neuropsychiatric adverse effects, was administered at treatment doses to detainees immediately upon their arrival at Guantánamo, prior to laboratory testing for malaria and irrespective of symptoms of disease. In this analysis, the history of mefloquine's development is reviewed and the indications for its administration at treatment doses are discussed. The stated rationale for the use of mefloquine among Guantánamo detainees is then evaluated in the context of accepted forms of population-based malaria control. It is concluded that there was no plausible public health indication for the use of mefloquine at Guantánamo and that based on prevailing standards of care, the clinical indications for its use are decidedly unclear. This analysis suggests the troubling possibility that the use of mefloquine at Guantánamo may have been motivated in part by knowledge of the drug's adverse effects, and points to a critical need for further investigation to resolve unanswered questions regarding the drug's potentially inappropriate use. Published 2012. This article is a US Government work and is in the public domain in the USA.

  4. Psychological distress amongst immigration detainees: a cross-sectional questionnaire study.

    Science.gov (United States)

    Robjant, Katy; Robbins, Ian; Senior, Victoria

    2009-09-01

    To compare levels of depression, anxiety, and post traumatic stress disorder (PTSD) amongst immigration detainees with a comparison group of asylum seekers living within the community. A cross-sectional questionnaire study. Sixty-seven detained asylum seekers, 30 detainees who had previously been imprisoned within the UK for criminal offences, and 49 asylum seekers living in the community completed the hospital anxiety and depression scale (HADS) and the impact of event scale-revised (IES-R). Demographic information was collected. High levels of anxiety, depression, and PTSD symptoms were reported by all three groups. Detained asylum seekers had higher scores than asylum seekers living within the community for depression, anxiety, and PTSD symptoms. There was an interaction between length of detention period and prior exposure to interpersonal trauma (IP trauma) on depression scores. Immigration detainees are highly vulnerable to psychological distress. A review of detention policies is recommended in light of this. Immigration detention may have an independent adverse effect on mental health. It is also possible that individuals with mental health problems may be more likely to be detained. Further research is required to investigate this.

  5. Pre-trial Intervention: The Manhattan Court Employment Project of the Vera Institute of Justice. Final Report.

    Science.gov (United States)

    Vera Inst. of Justice, New York, NY.

    The final report of an experimental pre-trial intervention program of intensive manpower services (individual and group counseling and job, training, or academic placement with the help of career developers) for selected defendants in Manhattan covers the period November 1967 through October 1970. After three years and 1,300 participants,…

  6. Association of Overcrowding and Turnover with Self-Harm in a Swiss Pre-Trial Prison.

    Science.gov (United States)

    Baggio, Stéphanie; Gétaz, Laurent; Tran, Nguyen Toan; Peigné, Nicolas; Chacowry Pala, Komal; Golay, Diane; Heller, Patrick; Bodenmann, Patrick; Wolff, Hans

    2018-03-27

    Self-harm is a common issue in detention and includes both suicidal and non-suicidal behaviours. Beyond well-known individual risk factors, institutional factors such as overcrowding (i.e., when the prison population exceeds its capacity) and turnover (i.e., the rate at which the prison population is renewed), may also increase the risk of self-harm. However, these factors are understudied or previous studies reported inconsistent findings. This study investigated the association of self-harm with overcrowding and turnover in the largest pre-trial Swiss prison in Geneva. Data were collected yearly between 2011 and 2017. Measures included self-harm (all kinds of self-injuring acts requiring medical attention, including self-strangulations and self-hangings). We performed meta-regressions to analyse the relationships between self-harm and institutional factors. Self-harm events were frequent, with a prevalence estimate of 26.4%. Overcrowding and turnover were high (average occupation rate of 177% and average turnover of 73%, respectively). Overcrowding and turnover were significantly associated with self-harm (respectively b = 0.068, p overcrowding and turnover increased. Overcrowding and turnover raise important human rights concerns and have damaging effects on the health of people living in detention. Identification of and care for this vulnerable population at risk of self-harm are needed and institutional factors should be addressed.

  7. Release from jail: moment of crisis or window of opportunity for female detainees?

    Science.gov (United States)

    McLean, Rachel L; Robarge, Jacqueline; Sherman, Susan G

    2006-05-01

    Despite extensive documentation of the reentry challenges facing female prisoners, few such studies have focused on women exiting jails. The Window Study investigated factors associated with the perceived availability of stable housing upon release from detention. Anonymous surveys were conducted with a random sample (n=148) of female detainees at the Baltimore City Detention Center from January 21 to March 17, 2005. Interviews focused on socio-demographic background, health status, recent drug use and sexual behavior history, and material and social resource availability upon release. The median age of female detainees was 37 (interquartile range [IQR]: 29, 41), 69% were African-American, and 33% identified as lesbian or bisexual. The median income in the 30 days prior to arrest was $145 (IQR: 0, 559), and the median number of prior arrests was 5 (IQR: 3, 11). In the presence of other variables familial support (Adjusted Odds Ratio [AOR] 2.57; 95% Confidence Interval [CI] 1.21, 5.47) and a monthly income of $400-799 (AOR 3.18; 95% CI 1.00, 10.07) were positively associated with perceived housing stability upon release; wanting a support group for having traded sex for money, drugs or a place to stay (AOR 0.25; 95% CI 0.10, 0.63) was significantly negatively associated with perceived housing stability upon release. This study suggests the importance of pre-release planning and continuity of care for female detainees. Interventions should emphasize access to housing, economic opportunity and family reunification. Special attention is warranted to those who have engaged in sex work, who may be marginalized from family and service-based support networks.

  8. Psychopathology and Borderline Personality Pathology Associated with Lifetime Self-Injurious Behavior in Adolescent Psychiatric Inpatients and Detainees.

    Science.gov (United States)

    Koenig, Julian; Brunner, Romuald; Schmidt, Johannes Michael; Parzer, Peter; Resch, Franz; Kaess, Michael

    2017-11-01

    Self-injurious behavior (SIB) is a widespread phenomenon among adolescent psychiatric inpatients. It is also reported among delinquent adolescents detained in correctional facilities. While previous studies have addressed different functions of SIB within offender populations, here we investigate particular patterns of borderline personality pathology and psychopathology underlying SIB in both adolescent psychiatric inpatients and detainees. Adolescent psychiatric inpatients and detainees were recruited consecutively. Participants completed self-reports on SIB, suicidal thoughts and behavior, borderline personality pathology, and general psychopathology. Predictors of lifetime SIB by group were analyzed. Psychiatric inpatients (n = 77) and detainees (n = 50) did not differ with respect to lifetime SIB (57.14 % versus 54.00 %), whereas SIB within the past year did (67.53 % versus 14 %; χ2 (1) = 6.158, p = .013). Psychiatric inpatients reported greater emotional problems (t (125) = 5.109, p borderline personality pathology. Those with lifetime SIB were characterized by greater emotional problems and borderline personality pathology, independent of their group. Results from regression analyses suggest no group-specific predictors of lifetime SIB. Although psychiatric inpatients endorse greater psychopathological distress, lifetime SIB among adolescent psychiatric inpatients and detainees is associated with similar patterns of psychopathology and borderline personality pathology.

  9. Regaining the Moral High Ground on Gitmo...is there a Basis for released Guantanamo Detainees to Receive Reparations?

    Science.gov (United States)

    2009-12-11

    Harvard International Law Journal 48 (18 April 2007):70-73. Martinez , Jenny S. “The Military Commissions Act and “Torture light”: Something for a...2004. 31Inquiry into the Treatment of Detainees, 3. 32Thomas and Hirsh. 33Inquiry into th 34Jenny S. Martinez , “The Military Commissio 35Inquiry

  10. Perspectives on recidivists: the views of detainees, the general public and people working with offenders

    Directory of Open Access Journals (Sweden)

    Antonio Iudici

    2018-03-01

    Full Text Available There is ample evidence on recidivism including its relationships with drug use, addiction, mental illness and security problems; however there has been less research based on direct accounts of detainee experiences and on the experience of people who try to prevent recidivism. The aim of this research was to describe how recidivism is perceived and dealt with by different actors: offenders (recidivists and non-recidivists, pedagogical operators and the public. The wider objective of the study was to identify ways in which various stakeholders can facilitate social reintegration of prisoners. The interviews revealed marked differences in how recidivism is interpreted; these affect both management of recidivism risk and the rehabilitation process, which involves society. The results suggest some ways of reducing recidivism, such as work groups among the actors involved, educational opportunities for offenders and the implementation of reintegration projects according to the laws on alternatives to prison.

  11. Psychologists and detainee interrogations: key decisions, opportunities lost, and lessons learned.

    Science.gov (United States)

    Pope, Kenneth S

    2011-01-01

    After the 9-11 terrorist attacks, U.S. psychologists faced hard choices about what roles, if any, were appropriate for psychologists in the detainee interrogations conducted in settings such as the Bagram Airbase, the Abu Ghraib Prison, and the Guantanamo Bay Detention Camps. The American Psychological Association (APA) sparked intense controversy with its policies and public statements. This article reviews APA decisions, documents, and public statements in this area, in the context of major criticisms and responses to those criticisms. The review focuses on key issues: how the APA created and reported policies in the areas of ethics and national security; transparency; psychologists' professional identities; psychologists' qualifications; ethical-legal conflicts; policies opposing torture; interpretations of avoiding harm; and effective interrogations. It suggests lessons learned, missed opportunities, and questions in need of a fresh approach. © 2011 by Annual Reviews. All rights reserved

  12. [Anxiety, depression, somatoform symptoms and posttraumatic stress in the offspring of political detainees in Eastern Germany (1945-1989)].

    Science.gov (United States)

    Klinitzke, Grit; Böhm, Maya; Brähler, Elmar; Weissflog, Gregor

    2012-01-01

    Between 1945 and 1989, approximately 300 000 persons were imprisoned because of political reasons in Eastern Germany. There is that evidence the detainees' offspring are affected by the trauma of their parents. In a study with cross-sectional design, depressive (PHQ-9), somatoform (PHQ-15) and anxiety symptomatology (GAD-7), and Posttraumatic Stress (IES-R) were assessed with self-rating measures in 43 children of former political prisoners. In comparison to 2 representative gender education and age matched samples from the general population, offspring of former political detainees show higher levels of psychopathological symptoms. The life-time prevalence for PTSD was 9.1%. Regarding the psychopathology, children who were born after their parents' imprisonment did not differ from those who were already born when the imprisonment happened. First evidence for the transgenerational transmission of traumatisation and the methods will be discussed critically. © Georg Thieme Verlag KG Stuttgart · New York.

  13. Drug Use and HIV Infection Status of Detainees in Re-Education through Labour Camps in Guangxi Province, China

    Directory of Open Access Journals (Sweden)

    Lei Zhang

    2015-04-01

    Full Text Available This study describes HIV disease burden and patterns of drug use before and during incarceration among detainees in Re-education-Through-Labour-Camps (RTLCs in China. A cross-sectional survey of 576 men and 179 women from three RTLCs was conducted in Guangxi Province, China. Over three-quarters of study participants were detained due to drug-related offences. Over half of the women (n = 313, 54.3% and two-thirds of men (n = 119, 66.5% had been previously been incarcerated in a compulsory detoxification treatment centre (CDTC, and around one-third (men n = 159, 27.6%; women n = 50, 27.9% in a RTLC. Of those surveyed, 49 men (8.5% and one (0.6% woman reported ever using drugs while in a CDTC and/or RTLC. Previous incarceration in CDTCs and RTLCs were associated with HIV infection among both male (OR = 2.15 [1.11–4.15] and female (OR = 3.87 [1.86–9.04] detainees. Being married/cohabiting with a partner (OR = 0.53, [0.30–0.93] and being employed (OR = 0.46, [0.22–0.95] were associated with a reduced odds of HIV infection among male detainees. A significant proportion of RTLC detainees had a history of drug use and a limited number of inmates had used illegal substances whilst in custody. Repeat incarcerations in CDTCs/RTLCs were associated with higher risks of HIV infection.

  14. The psychiatric profession and the Australian government: the debate over collective depression syndrome among asylum-seeking detainees.

    Science.gov (United States)

    Bostock, William W

    2009-01-01

    Psychiatrists have long had involvement with the political process, both individually and as a profession. They have made valuable contributions to debate over such issues as war, conflict, terrorism, torture, human rights abuse, drug abuse, suicide and other public health issues. However, they have also been complicit in some gross atrocities. Over several years there has been debate over the Australian Government's treatment of asylum seekers, and the Royal Australian and New Zealand College of Psychiatrists took the unusual step of publicly criticizing the Australian Government's policy on grounds of its toxicity leading to a diagnosis of collective depression syndrome, particularly among child detainees, but also adult detainees. The official Ministerial response was to deny that collective depression exists and to assert that the concept is meaningless. Can this intervention by psychiatrists be interpreted as a product of earlier political behaviors by psychiatrists? The willingness of psychiatrists to cooperate with other professions, notably psychologists, pediatricians, physicians and lawyers, is noted, as is presence of minority voices within the Australian psychiatric profession. The significance of the debate over the mental condition of asylum-seeking detainees is that its outcome has implications for how Australia sees itself and is seen by the rest of the world, that is, its national identity.

  15. The psychiatric profession and the Australian government: the debate over collective depression syndrome among asylum-seeking detainees

    Directory of Open Access Journals (Sweden)

    William W Bostock

    2009-11-01

    Full Text Available William W BostockSchool of Government, University of Tasmania, Hobart, Tasmania, AustraliaAbstract: Psychiatrists have long had involvement with the political process, both individually and as a profession. They have made valuable contributions to debate over such issues as war, conflict, terrorism, torture, human rights abuse, drug abuse, suicide and other public health issues. However, they have also been complicit in some gross atrocities. Over several years there has been debate over the Australian Government’s treatment of asylum seekers, and the Royal Australian and New Zealand College of Psychiatrists took the unusual step of publicly criticizing the Australian Government’s policy on grounds of its toxicity leading to a diagnosis of collective depression syndrome, particularly among child detainees, but also adult detainees. The official Ministerial response was to deny that collective depression exists and to assert that the concept is meaningless. Can this intervention by psychiatrists be interpreted as a product of earlier political behaviors by psychiatrists? The willingness of psychiatrists to cooperate with other professions, notably psychologists, pediatricians, physicians and lawyers, is noted, as is presence of minority voices within the Australian psychiatric profession. The significance of the debate over the mental condition of asylum-seeking detainees is that its outcome has implications for how Australia sees itself and is seen by the rest of the world, that is, its national identity.Keywords: collective depression syndrome, psychiatric profession, political intervention, asylum seeker, Australian national identity

  16. Detainees in police custody in the Paris, France area: medical data and high-risk situations (a prospective study over 1 year).

    Science.gov (United States)

    Chariot, Patrick; Beaufrère, Aurélie; Denis, Céline; Dang, Catherine; Vincent, Renaud; Boraud, Cyril

    2014-09-01

    The annual number of detainees held in police custody in France is approximately 700,000. Medical data regarding arrestees are scarce across countries. We present the medical characteristics of detainees kept in police custody, including addictive behaviours and high-risk medical situations. We conducted a prospective study over 1 year in a suburban area near Paris. A total of 19,098 medical examinations were performed on 13,317 individuals. The examinations mainly concerned male subjects (18,116 of 19,098, 95 %). Median age was 24 years (range 13-83). Medical examination was requested by the detainee in 6,638 of 16,801 cases (40 %). Assaults were reported in 4,052 of 17,312 cases (23 %) and occurred at the time of arrest in most cases (2,243, 13 %). A total of 2,394 of 13,317 detainees (18 %) had at least one chronic somatic disorder including asthma (603, 5 %), diabetes (263, 2 %) and arterial hypertension (205, 2 %). A history of psychiatric disorder was reported by 6 % of individuals (674 of 11,787). Regular alcohol drinking was reported by 58 % of detainees. Illicit drug use mainly involved cannabis (4,021 cases, 30 %). In 14,661 of 19,098 cases (77 %), detainees were considered to be unconditionally fit for detention in custody, and 274 detainees (1 %) were declared unfit to be detained. The present study showed a high frequency of alcohol or substance use and reported assaults or traumatic lesions in arrestees. Attending physicians should pay particular attention to addictive behaviours and traumatic injuries in arrestees, both for immediate care and for prevention.

  17. Detainees, staff, and health care services in immigration detention centres: a descriptive comparison of detention systems in Sweden and in the Benelux countries

    Directory of Open Access Journals (Sweden)

    Soorej J. Puthoopparambil

    2016-03-01

    Full Text Available Background: Immigration detention has been shown to negatively affect the health and well-being of detainees. The aim of the study was to describe and compare policies and practices that could affect the health and well-being of immigrant detainees in the Benelux countries (Belgium, the Netherlands, and Luxembourg to those in Sweden. Design: This was a case study. Data were collected in two phases using a questionnaire developed particularly for this study. In the first phase, authorities in the Benelux countries responded to the questionnaire via email. During the second phase, a research team visited detention centres in the Benelux countries to observe and further explore, strengthening findings through triangulation. Data on Swedish detention centres were collected in previous studies. Results: Compared to the Benelux countries, Sweden has limited health care provision available in the detention centres. Swedish detention centres did not have mental health care professionals working at the centres and had fewer restrictions within the centres with regard to access to mobile phone, internet, and various recreational activities. Compared to Sweden, the detention centres in the Benelux countries have more staff categories providing services to the detainees that are provided with relevant and timely on-the-job training. All the countries, except Belgium, provide subsistence allowances to detainees. Conclusion: Despite the Common European Asylum System framework, differences exist among the four European Union member states in providing services to immigrant detainees. This study highlights these differences, thereby providing a window on how these diverse approaches may serve as a learning tool for improving services offered to immigrant detainees. In Sweden, the health care available to detainees and training and recruitment of staff should be improved, while the Benelux countries should strive to reduce restrictions within detention centres.

  18. Addressing All Heads of the Hydra: Reframing Safeguards for Mentally Impaired Detainees in Immigration Removal Proceedings.

    Science.gov (United States)

    Wilson, Amelia; Prokop, Natalie H; Robins, Stephanie

    2015-01-01

    This article concerns the constitutional rights of detained, mentally impaired non-citizens in defending against deportation. Due process requires that such detainees receive a full and fair hearing. However, until recently, they were not provided an attorney to assist them in navigating our extremely complicated immigration system. Mentally impaired detainees were expected to proceed alone in proving the elements of their claims against skilled government attorneys--a daunting task even for those unencumbered by a mental disorder. On December 31, 2013, the Department of Justice ("DOJ") released guidelines detailing new procedures for how immigration courts should handle these cases, including the provision of counsel upon a finding of mental incompetence. The guidelines were issued as a direct response to Franco-Gonzales v. Holder, a class action lawsuit brought by the American Civil Liberties Union in federal district court in California seeking appointed counsel for detained, unrepresented, mentally impaired non-citizens. The guidelines created a three-stage process for assessing competency. Only at the end of this process--and after an individual is declared incompetent--is counsel appointed. This article argues that the DOJ guidelines fall far short of Franco's promise of due process for this particularly vulnerable population. It proposes an alternative model wherein counsel is appointed the moment the court is presented with "indicia" of incompetence, rather than after an adjudication of incompetence. "Indicia" should create a presumption of incompetency that can be rebutted only after a forensic evaluation is conducted and the court holds a robust hearing into the matter. This article reveals, through empirical evidence, the critical role that counsel plays in the investigation of a respondent's ability to participate in the proceedings, and how an attorney is often the only party positioned to marshal all the evidence relevant to the question of competency

  19. The Principle of Justice Administered Only by the Court When Making a Pre-Trial Cooperation Agreement and Special Trial Order

    Directory of Open Access Journals (Sweden)

    Suvorova A. A.

    2015-01-01

    Full Text Available The article investigates the problems of realization of the principle of justice administered only by the court in special conditions of judicial proceedings, suggests the ways of optimizing the procedure of making a pre-trial cooperation agreement.

  20. Violence exposure and health related risk among African American adolescent female detainees: A strategy for reducing recidivism.

    Science.gov (United States)

    Woodson, Kamilah M; Hives, Courtney; Sanders-Phillips, Kathy

    2010-11-01

    Juvenile crime and violent victimization continue to be significant social problems (Fitzpatrick, Piko, Wright, & LaGory, 2005); in that, adolescents, females in particular, are likely to participate in health related risk behaviors as result of having been victimized or exposed to a violent environment. Specifically, abuse, neglect, sexual molestation, poverty, and witnessing violence are well known risk factors for the development of trauma-related psychopathology and poor outcomes relative to delinquency, drug and alcohol abuse, and HIV risk behaviors (Steiner, Garcia, & Matthews, 1997). HIV infection is a common public health concern disproportionally affecting adolescent African American female detainees. This unique population has a serious history of violence exposure, which subsequently tends to lead to engaging in risky sexual behaviors, mental health problems, and abusing substances. Also, as a result of little to no intervention, this population is recidivating at an alarming rate, a problem that may further exacerbate the expression of health-related risk behaviors among African American adolescent female detainees. The authors briefly describe a pilot program to be implemented in the juvenile justice system that is based on the Model of Accumulated Risk (Garbarino, 1996), Bronfenbrenner's Ecological Model (1994), and the Positive Youth Justice Model (Butts, Bazemore, & Meroe, 2009). The program proposes to reduce risky sexual behaviors, teach alternatives to abusing substances, treat mental health concerns, and reduce the rate of recidivism through "positive youth development", PYD (Butts, Bazemore, & Meroe, 2009). Tying elements of wraparound services and reeducation together, this program addresses salient concerns that may have an impact on an adolescent detainees' success following their release from prison in a holistic manner.

  1. Recent Trends in Alcohol and Other Drug Use Among Police Detainees in New Zealand, 2010-2015.

    Science.gov (United States)

    Wilkins, Chris; Prasad, Jitesh; Parker, Karl; Rychert, Marta; Barnes, Helen Moewaka

    New Zealand has unusual patterns of recreational substance use by international standards including low levels of cocaine and heroin use, and high methamphetamine use. This paper examines recent trends in alcohol and other drug use among police detainees in New Zealand over the past six years. The paper utilises data from the New Zealand Arrestee Drug Use Monitoring (NZ-ADUM) study. NZ-ADUM interviewed approximately 800 police detainees each year at four central city police watch houses (i.e. Whangarei, Auckland, Wellington, Christchurch) from 2010 to 2015. The proportion of police detainees who had used methamphetamine in the previous year increased from 28% in 2012 to 36% in 2015. Drinking prior to arrest declined from 41% in 2013 to 28% in 2015. The use of cannabis in the past year declined slightly from 76% in 2011 to 69% in 2015. The proportion using ecstasy in the previous year steadily declined from 28% in 2011 to 19% in 2015. Only small minorities had recently used cocaine or an opioid. Use of methamphetamine and ecstasy increased in Christchurch. Growing methamphetamine use is consistent with record seizures of methamphetamine over the past 2-3 years. Increasing drug use in Christchurch may reflect factors related to the devastating earthquakes in 2011 and the subsequent city rebuild, including an influx of construction workers, more organised trafficking groups and earthquake-related stress. The decline in cannabis use may be related to the emergence of 'legal' synthetic cannabinoids. The decline in ecstasy use may be the result of recent domestic enforcement operations and the overall global shortage of MDMA. The decline in alcohol drinking may be due to the introduction of pre-charge formal warnings for minor alcohol and disorder offences, and new restrictions on alcohol premise opening hours. Acknowledgements: The New Zealand Drug Use Monitoring (NZ-ADUM) research study is funded by the New Zealand Police and is conducted by SHORE and Whariki Research

  2. Victims’ Rights and the Right to Review: A Corollary of the Victim’s Pre-Trial Rights to Justice

    Directory of Open Access Journals (Sweden)

    Tyrone Kirchengast

    2016-12-01

    Full Text Available In R v Christopher Killick [2011] EWCA Crim 1608, the Criminal Division of the Court of Appeal for England and Wales gave a decision setting out the rights of a crime victim to seek review of a Crown Prosecution Service (CPS decision not to prosecute and concluded that victims have the right to seek review in such circumstances. This included a recommendation that the right to review should be made the subject of clearer procedures and guidance. This paper discusses article 10 of the Proposal for a Directive of the European Parliament and of the Council, (2011 2011/0129 (COD 18 May 2011 establishing minimum standards on the rights, support and protection of victims of crime (see article 11 Final Directive as applied in the Killick case. The paper further discusses the implementation of Killick in prosecution policy, namely in the CPS guideline on the victims’ right to review (Director of Public Prosecutions for England and Wales 2014. The right to review will be canvassed in light the existing framework of victim rights available during the pre-trial phase and, in particular, the right to private prosecution, access to counsel, and adjunctive and extra-curial rights from declarations or charters of victim rights.

  3. Violence exposure and health related risk among African American adolescent female detainees: A strategy for reducing recidivism

    Science.gov (United States)

    Woodson, Kamilah M.; Hives, Courtney; Sanders-Phillips, Kathy

    2010-01-01

    Juvenile crime and violent victimization continue to be significant social problems (Fitzpatrick, Piko, Wright, & LaGory, 2005); in that, adolescents, females in particular, are likely to participate in health related risk behaviors as result of having been victimized or exposed to a violent environment. Specifically, abuse, neglect, sexual molestation, poverty, and witnessing violence are well known risk factors for the development of trauma-related psychopathology and poor outcomes relative to delinquency, drug and alcohol abuse, and HIV risk behaviors (Steiner, Garcia, & Matthews, 1997). HIV infection is a common public health concern disproportionally affecting adolescent African American female detainees. This unique population has a serious history of violence exposure, which subsequently tends to lead to engaging in risky sexual behaviors, mental health problems, and abusing substances. Also, as a result of little to no intervention, this population is recidivating at an alarming rate, a problem that may further exacerbate the expression of health-related risk behaviors among African American adolescent female detainees. The authors briefly describe a pilot program to be implemented in the juvenile justice system that is based on the Model of Accumulated Risk (Garbarino, 1996), Bronfenbrenner’s Ecological Model (1994), and the Positive Youth Justice Model (Butts, Bazemore, & Meroe, 2009). The program proposes to reduce risky sexual behaviors, teach alternatives to abusing substances, treat mental health concerns, and reduce the rate of recidivism through “positive youth development”, PYD (Butts, Bazemore, & Meroe, 2009). Tying elements of wraparound services and reeducation together, this program addresses salient concerns that may have an impact on an adolescent detainees’ success following their release from prison in a holistic manner. PMID:21373205

  4. Mental Rehabilitation of Juvenile Girl Detainees for Increasing Their Self-Esteem Through the Self Knowledge Sources

    Directory of Open Access Journals (Sweden)

    Shiva Saeghi Mameghani

    2011-04-01

    Full Text Available Objectives: The main purpose of the present study is to consider the rate of impression in group mental rehabilitation based on the regulation of self recognition sources on augmentation of self-respect among 14- to 18-year old female prisoners. Methods: 30 female social seekers were randomly selected from the whole population, 15 of which were gathered in control group and the rest 15 within evidence group. First, GHQ papers (General Health Questionnaire were distributed among the girls in order to evaluate their mental status. Pre- and Post- Cooper Smith self-respect tests were formulated both before and after interventions on experiment group. Interventions were accomplished during 9 sessions within three months by group consulting based on the configuration of self-recognition (collected by Younesi 2007. Considering the point that remedy plans are not utilized for the evidence group and they are evaluated by gathered marks achieved by the two tests to compare average discriminations. Results: After applying remedy interventions, social seekers from experimental group manifested meaningful augmentation during the test of self-esteem invented by Cooper Smith compared with social help seekers from control group. Discussion: The findings indicated that group mental rehabilitation would increase self-esteem in its four dimensions among the subjects. The findings showed that mental rehabilitation based on self knowledge resources is useful for improvement of juvenile detainee's self-esteem.

  5. Post-release substance abuse outcomes among HIV-infected jail detainees: results from a multisite study.

    Science.gov (United States)

    Krishnan, Archana; Wickersham, Jeffrey A; Chitsaz, Ehsan; Springer, Sandra A; Jordan, Alison O; Zaller, Nick; Altice, Frederick L

    2013-10-01

    HIV-infected individuals with substance use disorders have a high prevalence of medical and psychiatric morbidities that complicate treatment. Incarceration further disrupts healthcare access and utilization. Without appropriate diagnosis and treatment, drug relapse upon release exceeds 85 %, which contributes to poor health outcomes. A prospective cohort of 1,032 HIV-infected jail detainees were surveyed in a ten-site demonstration project during incarceration and six-months post-release, in order to examine the effect of predisposing factors, enabling resources and need factors on their subsequent drug use. Homelessness, pre-incarceration cocaine and opioid use, and high drug and alcohol severity were significantly associated with cocaine and opioid relapse. Substance abuse treatment, though poorly defined, did not influence post-release cocaine and opioid use. An approach that integrates multiple services, simultaneously using evidence-based substance abuse, psychiatric care, and social services is needed to improve healthcare outcomes for HIV-infected persons transitioning from jails to the community.

  6. Download this PDF file

    African Journals Online (AJOL)

    Paralegals play a valuable role in reducing prison overcrowding by locating the family members of pre-trial detainees and facilitating bail hearings. This article gives an overview of paralegal services in a number of African countries, and shows how these services are assisting thousands of pre- trial detainees and accused ...

  7. Is tattooing a risk factor for adolescents' criminal behavior? Empirical evidence from an administrative data set of juvenile detainees in Taiwan.

    Science.gov (United States)

    Liao, Pei-An; Chang, Hung-Hao; Su, Yi-Ju

    2014-12-01

    Juvenile crime affects not only the victims of the crime but also the delinquents' future. How to prevent adolescent criminal behavior has become an important public policy issue. This study contributes to this interesting issue by examining the relationship between tattooing and adolescents' criminal behavior. In particular, this study investigates whether or not having a tattoo/tattoos is connected to the incidence of various criminal activities, including: larceny, robbery, fraud, assault, drug use, and homicide. A unique sample of 973 juvenile detainees drawn from the administrative profiles in Taiwan and the coarsened exact matching method were utilized. Results show that compared to their nontattooed counterparts, tattooed juvenile detainees were significantly more likely to commit fraud, assault, drug abuse, and homicide by 3%, 13%, 9%, and 9%, respectively. In contrast, tattooing was not significantly associated with larceny or robbery. From a policy perspective, given the significant link between tattooing and criminal behavior, the presence of a tattoo in adolescents may serve as a valuable indicator regarding adolescents' high probability of committing crimes. © 2014 Society for Risk Analysis.

  8. SPECIAL RULES OF MITIGATION OF PUNISHMENT IN CASE OF THE CONCLUSION OF THE PRE-TRIAL COOPERATION AGREEMENT, AT THE SPECIAL PROCEDURE OF FOR THE TRIAL AND AT THE SHORTENED ORDER OF INQUIRY

    Directory of Open Access Journals (Sweden)

    Tatiana Nepomnyashchaya

    2017-01-01

    Full Text Available The subject. The article analyzes the rules for the appointment of punishment in the case of a pre-trial cooperation agreement, with a special procedure for the trial and with a shortened procedure of conducting inquiry, regulated by art. 62 of the RF Criminal Code “Turning out a Sentence when Mitigating Circumstances Exist”. The authors give an answer to two questions: 1 Does the legal nature of these institutions correspond to the legal nature of mitigating circumstances; 2 Is it advisable to consolidate in a one article of the law different legal regulations.Methodology. Authors use such researching methods as analysis and synthesis, formally legal, comparative legal.Results. Rules for the appointment of punishment in the conclusion of a pre-trial cooperation agreement, stipulated by the pt. 2, 4 of art. 62 of the RF Criminal Code, regulate not the order of accounting for mitigating circumstances, but the legal consequences associated with the promotion of a person, which concluded and executed a pre-trial cooperation agreement, that does not correspond to the legal nature of the pt. 1, 3 of art. 62 of the RF Criminal Code.The legal nature of the rules for the appointment of punishment, established in pt. 5 of art. 62 of the RF Criminal Code, also does not correspond to the legal nature of the rules for the imposition of punishment in the presence of mitigating circumstances, because mitigation of punishment occurs on criminal procedural grounds, which are not mitigating circumstances.Conclusions. In authors opinion, fastening in art. 62 of the RF Criminal Code of three independent rules for the imposition of punishment, namely, the rules for the imposition of punishment in the presence of mitigating circumstances (pt. 1, 3 of art. 62 of the Criminal Code, at the conclusion of a pre-trial cooperation agreement (pt. 2, 4 of art. 62 of the Crim-inal Code, with a special order of the trial and a shortened procedure for conducting an inquiry

  9. Causes of death among detainees: a statistical study on the casework of the Forensic Medicine Institute in Cluj-Napoca during the period 2000-2014.

    Science.gov (United States)

    Gherman, Cristian; Chiroban, Ovidiu

    2015-01-01

    The detainees' right to healthcare is granted by laws, in accordance with EU directives and recommendations to which our country has consented. Prison population is a particularly vulnerable and marginalized group characterized by mortality rates different from the general population. This study aims at providing a picture of the causes of death, quality of healthcare and measures needed to reduce the number of in-prison deaths, including legal medicine expertise in view of sentence postponement/interruption. The present paper is based on the statistical analysis of in-prison deaths casework recorded at the Forensic Medicine Institute of Cluj-Napoca and provided by territorially subordinated counties forensic services. The data collected cover over 15 years (2000-2014), a period long enough for significant retrospective statistical analysis. The total number of deaths among the inmates was 113, the majority of male sex (110). Distribution by age groups shows a greater incidence among inmates aged 50 to 59 years (32 cases, 28.31%), followed by those in their 40s' (30 cases, 26.54%) and 30s' (25 cases, 22.12%). The most frequent pathological causes of death were cardiovascular (53 cases) followed by tumors (26 cases) and infectious diseases. A significant number of deaths were due to violent causes (14 cases-12,38%). Special problems are raised by the high number of deaths among prisoners, especially at a young age, while the high frequency of violent deaths from self- or non-self-inflicted traumatic causes requires supervision, monitoring and continuous analysis. Despite recent improvements, healthcare in prisons still poses some problems, mainly regarding diagnosis and treatment of heart diseases, neurosurgery and cancer.

  10. Interrogation of Detainees: Requirements of the Detainee Treatment Act

    National Research Council Canada - National Science Library

    Garcia, Michael J

    2009-01-01

    ...), which was enacted pursuant to both the Department of Defense, Emergency Supplemental Appropriations to Address Hurricanes in the Gulf of Mexico, and Pandemic Influenza Act, 2006 (P.L. 109-148, Title X...

  11. Prison Reforms in Mozambique fail to Touch the Ground: Assessing ...

    African Journals Online (AJOL)

    This article presents the findings of research on pre-trial detention in the Mozambique capital city Maputo. Conditions of detention and access to legal representation of a group of pre-trial detainees are analysed within the context of development of the prison system in Mozambique. The research shows that while progress ...

  12. Intrathecal Trialing of Continuous Infusion Combination Therapy With Hydromorphone and Bupivacaine in Failed Back Surgery Patients.

    Science.gov (United States)

    Galica, Ryan J; Hayek, Salim M; Veizi, Elias; McEwan, Matthew T; Katta, Sivakanth; Ali, Omar; Aziz, Nida; Sondhi, Nidhi

    2017-12-05

    Intrathecal (IT) trial is a prognostic interventional pain management procedure employed to determine the potential success of treating intractable pain with an implantable infusion device system. There is a dearth of data regarding trials with continuous infusion of combination therapy (e.g. opioid combined with local anesthetic). The objective of the this study was to determine the overall outcomes of continuous infusion IT trials and factors influencing long-term success of IT therapy in patients with chronic intractable pain post-laminectomy. This is a retrospective analysis of all patients with lumbar failed back surgery syndrome (FBSS) who were trialed with a combination of hydromorphone and bupivacaine with a temporary externalized IT catheter from March 2007 to June 2014. From a cohort of 62 patients fulfilling the inclusion criteria, 54 (87.10%) patients had successful IT trials. No significant differences were found between successful and failed trial patients with regards to age, sex, pre-trial pain numeric rating scale scores, pre-trial morphine equivalent daily dose, or trial dosages. Significant positive correlations were found between pretrial oral opioid intake and end of trial hydromorphone dose and hydromorphone dose escalation at 12 months and 24 months. Patients with refractory low back pain due to FBSS who underwent successful combination IT trial with hydromorphone and bupivacaine infused through a temporary IT catheter had significantly improved pain intensity scores following permanent implant. Higher pre-trial MEDD was correlated with higher trial and post-implant opioid doses and higher rates of opioid dose escalation post-implant. © 2017 International Neuromodulation Society.

  13. Winning Combinations

    DEFF Research Database (Denmark)

    Criscuolo, Paola; Laursen, Keld; Reichstein, Toke

    2018-01-01

    Searching for the most rewarding sources of innovative ideas remains a key challenge in management of technological innovation. Yet, little is known about which combinations of internal and external knowledge sources are triggers for innovation. Extending theories about searching for innovation, we...... examine the effectiveness of different combinations of knowledge sources for achieving innovative performance. We suggest that combinations involving integrative search strategies – combining internal and external knowledge – are the most likely to generate product and process innovation. In this context...

  14. Combination vaccines

    Directory of Open Access Journals (Sweden)

    David AG Skibinski

    2011-01-01

    Full Text Available The combination of diphtheria, tetanus, and pertussis vaccines into a single product has been central to the protection of the pediatric population over the past 50 years. The addition of inactivated polio, Haemophilus influenzae, and hepatitis B vaccines into the combination has facilitated the introduction of these vaccines into recommended immunization schedules by reducing the number of injections required and has therefore increased immunization compliance. However, the development of these combinations encountered numerous challenges, including the reduced response to Haemophilus influenzae vaccine when given in combination; the need to consolidate the differences in the immunization schedule (hepatitis B; and the need to improve the safety profile of the diphtheria, tetanus, and pertussis combination. Here, we review these challenges and also discuss future prospects for combination vaccines.

  15. Combination Vaccines

    OpenAIRE

    Skibinski, David AG; Baudner, Barbara C; Singh, Manmohan; O’Hagan, Derek T

    2011-01-01

    The combination of diphtheria, tetanus, and pertussis vaccines into a single product has been central to the protection of the pediatric population over the past 50 years. The addition of inactivated polio, Haemophilus influenzae, and hepatitis B vaccines into the combination has facilitated the introduction of these vaccines into recommended immunization schedules by reducing the number of injections required and has therefore increased immunization compliance. However, the development of th...

  16. Combined homicide

    Directory of Open Access Journals (Sweden)

    Slović Živana

    2017-01-01

    Full Text Available Introduction: Combined homicide is a combination of two or more different modes of killing. These homicides occur when multiple perpetrators have different mode of killing, to hide the true manner of death, or when an initially unsuccessful attack with one weapon is abandoned and changed by another mode which is more successful, or due to availability of weapons at the scene of homicide, or unexpected appearance of possible eyewitness, or else. Case report: This case report is about 65-year old woman who was found in her residence on the floor next to the bed lying on her back with two kitchen knives in her neck. Autopsy revealed an abrasion on the frontal part of the neck and a bruise of the soft tissues of the neck with a double fracture of both greater horns of the hyoid bone and a fracture of both superior horns of the thyroid cartilage. The cause of death was exsanguination into right half of the thoracic cavity from the left subclavian artery which was cut, on the spot of stab wound in the neck. Conclusion: Hemorrhage in the soft tissue near broken hyoid bone and thyroid cartilage indicate that the victim was first strangulated and then stabbed with kitchen knives. Combined homicides are caused by one or more killers in order to accelerate the killing, or to be sure to provide the fatal outcome. This case is also interesting because the killer left weapon in the victim's neck.

  17. Guantanamo Bay Detainees: Facilities and Factors for Consideration If Detainees Were Brought to the United States

    Science.gov (United States)

    2012-11-01

    Terre Haute, Indiana 45 Abbreviations ADX U.S. Penitentiary Florence Administrative-Maximum AUMF Authorization for Use of Military...punishable by imprisonment for more than one year may be confined in any United States penitentiary .”). BOP officials noted that under this statute...in double-bunk cells. Inmates in the Communications Management Unit at Marion U.S. Penitentiary (Marion, Illinois) are ordinarily housed in single

  18. Dexketoprofen/tramadol: randomised double-blind trial and confirmation of empirical theory of combination analgesics in acute pain.

    Science.gov (United States)

    Moore, R Andrew; Gay-Escoda, C; Figueiredo, R; Tóth-Bagi, Z; Dietrich, T; Milleri, S; Torres-Lagares, D; Hill, C M; García-García, A; Coulthard, P; Wojtowicz, A; Matenko, D; Peñarrocha-Diago, M; Cuadripani, S; Pizà-Vallespir, B; Guerrero-Bayón, C; Bertolotti, M; Contini, M P; Scartoni, S; Nizzardo, A; Capriati, A; Maggi, C A

    2015-01-01

    Combination analgesics are effective in acute pain, and a theoretical framework predicts efficacy for combinations. The combination of dexketoprofen and tramadol is untested, but predicted to be highly effective. This was a randomised, double-blind, double-dummy, parallel-group, placebo-controlled, single-dose trial in patients with moderate or severe pain following third molar extraction. There were ten treatment arms, including dexketoprofen trometamol (12.5 mg and 25 mg) and tramadol hydrochloride (37.5 mg and 75 mg), given as four different fixed combinations and single components, with ibuprofen 400 mg as active control as well as a placebo control. The study objective was to evaluate the superior analgesic efficacy and safety of each combination and each single agent versus placebo. The primary outcome was the proportion of patients with at least 50 % max TOTPAR over six hours. 606 patients were randomised and provided at least one post-dose assessment. All combinations were significantly better than placebo. The highest percentage of responders (72%) was achieved in the dexketoprofen trometamol 25 mg plus tramadol hydrochloride 75 mg group (NNT 1.6, 95% confidence interval 1.3 to 2.1). Addition of tramadol to dexketoprofen resulted in greater peak pain relief and greater pain relief over the longer term, particularly at times longer than six hours (median duration of 8.1 h). Adverse events were unremarkable. Dexketoprofen trometamol 25 mg combined with tramadol hydrochloride 75 mg provided good analgesia with rapid onset and long duration in a model of moderate to severe pain. The results of the dose finding study are consistent with pre-trial calculations based on empirical formulae. EudraCT (2010-022798-32); Clinicaltrials.gov (NCT01307020).

  19. Is the Combination of Insecticide and Mating Disruption Synergistic or Additive in Lightbrown Apple Moth, Epiphyas postvittana?

    Science.gov (United States)

    Suckling, David M; Baker, Greg; Salehi, Latif; Woods, Bill

    2016-01-01

    Pest suppression from combinations of tactics is fundamental to pest management and eradication. Interactions may occur among tactical combinations and affect suppression. The best case is synergistic, where suppression from a combination is greater than the sum of effects from single tactics (AB > A+B). We explored how mating disruption and insecticide interacted at field scale, additively or synergistically. Use of a pheromone delivery formulation (SPLAT™) as either a mating disruption treatment (i.e. a two-component pheromone alone) or as a lure and kill treatment (i.e. the two-component pheromone plus a permethrin insecticide) was compared for efficacy against the lightbrown apple moth Epiphyas postvittana. Next, four point-source densities of the SPLAT™ formulations were compared for communication disruption. Finally, the mating disruption and lure and kill treatments were applied with a broadcast insecticide. Population assessment used virgin female traps and synthetic pheromone in replicated 9-ha vineyard plots compared with untreated controls and insecticide-treated plots, to investigate interactions. Lure and kill and mating disruption provided equivalent suppression; no additional benefit accrued from including permethrin with the pheromone suggesting lack of contact. The highest point-source density tested (625/ha) was most effective. The insect growth regulator methoxyfenoxide applied by broadcast application lowered pest prevalence by 70% for the first ten weeks compared to pre-trial. Pheromone addition suppressed the pest further by an estimated 92.5%, for overall suppression of 97.7% from the treatment combination of insecticide plus mating disruption. This was close to that expected for an additive model of interactivity between insecticide and mating disruption (AB = A+B) estimated from plots with single tactics as 98% suppression in a combination. The results indicate the need to examine other tactical combinations to achieve the potential

  20. When detainees have a disability: Their rights and fundamental freedoms.

    Science.gov (United States)

    Nowak, Manfred; Zarraluqui, Adriana

    2009-01-01

    This article describes and clarifies the human rights of persons with disabilities in the context of detention in light of the recently adopted and already in force Convention on the Rights of Persons with Disabilities (the Convention). Focusing on the Convention, the article sheds light on the legality of certain forms of detention affecting persons with disabilities, the substantive and procedural requirements for their detention, and on their rights in relation to conditions of detention. This article also provides an account of the different treatments and practices inflicted on persons with disabilities in prisons and other institutions and assesses whether they constitute torture and ill treatment. The authors argue that the Convention on the Rights of Persons with Disabilities represents a paradigm shift that requires States to modify and adopt laws, policies and practices that fully respect the right to liberty of persons with disabilities, and their equal enjoyment of rights while in detention, including the right to be free from torture and ill treatment.

  1. Transition Services for Juvenile Detainees with Disabilities: Findings on Recidivism

    Science.gov (United States)

    Clark, Heather Griller; Mathur, Sarup R.; Helding, Brandon

    2011-01-01

    This study explores the effect of basic versus enhanced transition services on the recidivism of youth with disabilities in juvenile detention. The article describes the transition services provided and shares the results of a year-long, randomized, single blind, quasi-experimental study of post-release recidivism. Results indicate that youth with…

  2. Interrogation of Detainees: Overview of the McCain Amendment

    National Research Council Canada - National Science Library

    Garcia, Michael J

    2006-01-01

    ...), which was enacted pursuant to both the Department of Defense, Emergency Supplemental Appropriations to Address Hurricanes in the Gulf of Mexico, and Pandemic Influenza Act, 2006 (P.L. 109-148...

  3. Boumediene v. Bush: Guantanamo Detainees' Right to Habeas Corpus

    National Research Council Canada - National Science Library

    Garcia, Michael J

    2008-01-01

    In the consolidated cases of Boumediene v. Bush and Al Odah v. United States, decided June 12, 2008, the Supreme Court held in a 5-4 opinion that aliens designated as enemy combatants and detained at the U.S...

  4. Enemy Combatant Detainees: Habeas Corpus Challenges in Federal Court

    National Research Council Canada - National Science Library

    Elsea, Jennifer K; Thomas, Kenneth R

    2007-01-01

    .... The report summarizes pending legislation and provides an analysis of relevant constitutional issues, including whether the DTA provisions amount to a suspension of the Writ of Habeas Corpus within...

  5. Legal questions surrounding hunger strikes by detainees and prisoners.

    Science.gov (United States)

    Strauss, S A

    1991-01-01

    The 'right to die' is not of an absolute character but is subject to definite qualification. There are legal and social interests reflecting profound ethical values which militate against an absolute right on the part of a prisoner to die by means of a hunger strike. The declared policy of the South African authorities is that a prisoner who resorts to a hunger strike may not be subjected to force-feeding. This is in accordance with the 1975 Tokyo Declaration. Unfortunately the Declaration is silent on the question of whether a doctor may provide medical treatment once a hunger striker has reached the point where he is no longer capable of rational thought. In this article it is submitted that a doctor would be legally entitled to do so.

  6. Judicial Activity Concerning Enemy Combatant Detainees: Major Court Rulings

    Science.gov (United States)

    2010-04-01

    13 United States v. Lindh , 227 F. Supp. 2d 565...convicted for his role in the September 11, 2001, terrorist attacks, but was never officially designated as an “enemy combatant”; John Walker Lindh , thus far...instructed that the sentencing options were limited as part of an apparently successful strategy to avoid the death penalty. United States v. Lindh , 227

  7. "Enhanced" interrogation of detainees: do psychologists and psychiatrists participate?

    Directory of Open Access Journals (Sweden)

    Halpern John H

    2008-09-01

    Full Text Available Abstract After revelations of participation by psychiatrists and psychologists in interrogation of prisoners at Guantánamo Bay and Central Intelligence Agency secret detention centers, the American Psychiatric Association and the American Psychological Association adopted Position Statements absolutely prohibiting their members from participating in torture under any and all circumstances, and, to a limited degree, forbidding involvement in interrogations. Some interrogations utilize very aggressive techniques determined to be torture by many nations and organizations throughout the world. This paper explains why psychiatrists and psychologists involved in coercive interrogations violate the Geneva Conventions and the laws of the United States. Whether done with ignorance of professional ethical obligations or not, these psychiatrists and psychologists have crossed an ethical barrier that may best be averted from re-occurring by teaching medical students and residents in all medical specialties about the ethics principles stemming from the 1946–1947 Nuremberg trials and the Geneva Conventions, together with the Ethics Codes of the World Medical Association and the American Medical Association; and, with regard to psychiatric residents and psychological trainees, by the teaching about The Principles of Medical Ethics With Annotations Especially Applicable to Psychiatry and the Ethical Principles of Psychologists and Code of Conduct, respectively. In this way, all physicians and psychologists will clearly understand that they have an absolute moral obligation to "First, do no harm" to the human beings they professionally encounter.

  8. Pathways to Sexual Risk Taking among Female Adolescent Detainees

    Science.gov (United States)

    Lopez, Vera; Kopak, Albert; Robillard, Alyssa; Gillmore, Mary Rogers; Holliday, Rhonda C.; Braithwaite, Ronald L.

    2011-01-01

    Sexual risk taking among female delinquents represents a significant public health problem. Research is needed to understand the pathways leading to sexual risk taking among this population. This study sought to address this issue by identifying and testing two pathways from child maltreatment to non-condom use among 329 White and 484 African…

  9. Treat Jail Detainees' Drug Abuse to Lower HIV Transmission

    Science.gov (United States)

    ... Behavior Smoking Stimulant Drug Therapy for ADHD Stress Withdrawal See All NIDA Notes Articles Get this Publication ... NIDA Notes Fear of Distress Signals Risk for Opioid Misuse in Chronic Pain Patients Deep Brain Stimulation ...

  10. Birth control pills - combination

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000655.htm Birth control pills - combination To use the sharing features ... contain both progestin and estrogen. What Are Combination Birth Control Pills? Birth control pills help keep you ...

  11. COMBINE 2 seminar

    DEFF Research Database (Denmark)

    Sørensen, Lars Schiøtt; Jacobsen, Kim

    1995-01-01

    A seminar about the COMBINE project was described. Further, the project was described in generel, i.e. the COMBINE´s data model (IDM), the data exchange system (DES) and the different I/O-systems included in COMBINE 2......A seminar about the COMBINE project was described. Further, the project was described in generel, i.e. the COMBINE´s data model (IDM), the data exchange system (DES) and the different I/O-systems included in COMBINE 2...

  12. The Art of Combination

    NARCIS (Netherlands)

    Saskia Keuzenkamp; K. Breedveld; J.G.F. Merens

    2000-01-01

    Original title: De kunst van het combineren. The traditional breadwinner household has lost its dominant position once and for all. For the first time, the majority of Dutch couples are combining two paid jobs with looking after the household. Who are these 'combination artists'? It is found

  13. Trendwatch combining expert opinion

    NARCIS (Netherlands)

    Hendrix, E.M.T.; Kornelis, M.; Pegge, S.M.; Galen, van M.A.

    2006-01-01

    In this study, focus is on a systematic way to detect future changes in trends that may effect the dynamics in the agro-food sector, and on the combination of opinions of experts. For the combination of expert opinions, the usefulness of multilevel models is investigated. Bayesian data analysis is

  14. Practical, general parser combinators

    NARCIS (Netherlands)

    A. Izmaylova (Anastasia); A. Afroozeh (Ali); T. van der Storm (Tijs)

    2016-01-01

    textabstractParser combinators are a popular approach to parsing where contextfree grammars are represented as executable code. However, conventional parser combinators do not support left recursion, and can have worst-case exponential runtime. These limitations hinder the expressivity and

  15. Combination treatment for hypertension

    African Journals Online (AJOL)

    Combination therapy with two or more drugs will be necessary in the majority ... There are a number of likely combinations of drug therapy for hypertension .... similar reduction in blood pressure, is better tolerated, and seems to confer benefits beyond reduction in blood pressure. SCOPE. Study on. Cognition and. Prognosis ...

  16. PUVA combination therapy.

    Science.gov (United States)

    Morison, W L

    1985-08-01

    Various adjunctive treatments are now frequently used in combination with PUVA therapy with the aims of limiting adverse effects, improving efficacy and decreasing the cost of treatment. In the management of psoriasis, PUVA plus retinoids, PUVA plus methotrexate and PUVA plus UVB phototherapy are the most frequently used combinations. PUVA plus topical corticosteroids and PUVA plus anthralin are also efficacious but adverse effects and poor acceptance by patients are limiting factors. Combinations of PUVA plus nitrogen mustard and ionizing radiation are used in mycosis fungoides to treat tumors and residual disease in secluded sites. In the management of photodermatoses with PUVA therapy, prednisone is often required to prevent exacerbation of disease. A combination of prednisone and PUVA therapy can also be useful in lichen planus and atopic eczema. The selection of a suitable combination treatment, will depend upon the preferences of the clinician, the disease being treated, and the characteristics of the patient.

  17. Combinators for Paraconsistent Attitudes

    DEFF Research Database (Denmark)

    Villadsen, Jørgen

    2001-01-01

    of the lambda calculus possibly containing lexical and/or logical constants. Such combinators seem promising from both a cognitive and computational point of view. There is approximately one lexical combinator for each word, but just eleven logical combinators for the present fragment. The partiality is only...... used for embedded sentences expressing propositional attitudes, thereby allowing for inconsistency without explosion (also called paraconsistency), and is based on a few key equalities for the connectives giving four truth values (truth, falsehood, and undefinedness with negative and positive polarity...

  18. Wood-plastic combination

    International Nuclear Information System (INIS)

    Schaudy, R.

    1978-02-01

    A review on wood-plastic combinations is given including the production (wood and plastic component, radiation hardening, curing), the obtained properties, present applications and prospects for the future of these materials. (author)

  19. Severe Combined Immunodeficiency Disorders.

    Science.gov (United States)

    Chinn, Ivan K; Shearer, William T

    2015-11-01

    Severe combined immunodeficiency disorders represent pediatric emergencies due to absence of adaptive immune responses to infections. The conditions result from either intrinsic defects in T-cell development (ie, severe combined immunodeficiency disease [SCID]) or congenital athymia (eg, complete DiGeorge anomaly). Hematopoietic stem cell transplant provides the only clinically approved cure for SCID, although gene therapy research trials are showing significant promise. For greatest survival, patients should undergo transplant before 3.5 months of age and before the onset of infections. Newborn screening programs have yielded successful early identification and treatment of infants with SCID and congenital athymia in the United States. Copyright © 2015 Elsevier Inc. All rights reserved.

  20. Combinable protein crop production

    OpenAIRE

    Wright, Isobel

    2008-01-01

    This research topic review aims to summarise research knowledge and observational experience of combinable protein crop production in organic farming systems for the UK. European research on peas, faba beans and lupins is included; considering their role in the rotation, nitrogen fixation, varieties, establishment, weed control, yields, problems experienced and intercropping with cereals.

  1. Combined PET/MRI

    DEFF Research Database (Denmark)

    Bailey, D. L.; Pichler, B. J.; Gückel, B.

    2015-01-01

    This paper summarises key themes and discussions from the 4th international workshop dedicated to the advancement of the technical, scientific and clinical applications of combined positron emission tomography (PET)/magnetic resonance imaging (MRI) systems that was held in Tübingen, Germany, from...

  2. Children's First Word Combinations

    Science.gov (United States)

    Braine, Martin D. S.

    1976-01-01

    This monograph presents a descriptive analysis of the syntactic patterns in 16 corpora of word combinations from 11 infants learning either English (six children), Samoan, Finnish, Hebrew, or Swedish. The mean utterance lengths range up to about 1.7 morpehmes. There are both reanalyses of corpora in the literature and new corpora. The data…

  3. Maximising the value of combining qualitative research and randomised controlled trials in health research: the QUAlitative Research in Trials (QUART) study--a mixed methods study.

    Science.gov (United States)

    O'Cathain, Alicia; Thomas, Kate J; Drabble, Sarah J; Rudolph, Anne; Goode, Jackie; Hewison, Jenny

    2014-06-01

    Researchers sometimes undertake qualitative research with randomised controlled trials (RCTs) of health interventions. To systematically explore how qualitative research is being used with trials and identify ways of maximising its value to the trial aim of providing evidence of effectiveness of health interventions. A sequential mixed methods study with four components. (1) Database search of peer-reviewed journals between January 2008 and September 2010 for articles reporting the qualitative research undertaken with specific trials, (2) systematic search of database of registered trials to identify studies combining qualitative research and trials, (3) survey of 200 lead investigators of trials with no apparent qualitative research and (4) semistructured telephone interviews with 18 researchers purposively sampled from the first three methods. Qualitative research was undertaken with at least 12% of trials. A large number of articles reporting qualitative research undertaken with trials (n=296) were published between 2008 and 2010. A total of 28% (82/296) of articles reported qualitative research undertaken at the pre-trial stage and around one-quarter concerned drugs or devices. The articles focused on 22 aspects of the trial within five broad categories. Some focused on more than one aspect of the trial, totalling 356 examples. The qualitative research focused on the intervention being trialled (71%, 254/356), the design and conduct of the trial (15%, 54/356), the outcomes of the trial (1%, 5/356), the measures used in the trial (3%, 10/356), and the health condition in the trial (9%, 33/356). The potential value of the qualitative research to the trial endeavour included improving the external validity of trials and facilitating interpretation of trial findings. This value could be maximised by using qualitative research more at the pre-trial stage and reporting findings with explicit attention to the implications for the trial endeavour. During interviews

  4. Propagating Class and Method Combination

    DEFF Research Database (Denmark)

    Ernst, Erik

    1999-01-01

    number of implicit combinations. For example, it is possible to specify separate aspects of a family of classes, and then combine several aspects into a full-fledged class family. The combination expressions would explicitly combine whole-family aspects, and by propagation implicitly combine the aspects...

  5. Combination Chemotherapy for Influenza

    Directory of Open Access Journals (Sweden)

    Robert G. Webster

    2010-07-01

    Full Text Available The emergence of pandemic H1N1 influenza viruses in April 2009 and the continuous evolution of highly pathogenic H5N1 influenza viruses underscore the urgency of novel approaches to chemotherapy for human influenza infection. Anti-influenza drugs are currently limited to the neuraminidase inhibitors (oseltamivir and zanamivir and to M2 ion channel blockers (amantadine and rimantadine, although resistance to the latter class develops rapidly. Potential targets for the development of new anti-influenza agents include the viral polymerase (and endonuclease, the hemagglutinin, and the non-structural protein NS1. The limitations of monotherapy and the emergence of drug-resistant variants make combination chemotherapy the logical therapeutic option. Here we review the experimental data on combination chemotherapy with currently available agents and the development of new agents and therapy targets.

  6. Transfer function combinations

    KAUST Repository

    Zhou, Liang

    2012-10-01

    Direct volume rendering has been an active area of research for over two decades. Transfer function design remains a difficult task since current methods, such as traditional 1D and 2D transfer functions, are not always effective for all data sets. Various 1D or 2D transfer function spaces have been proposed to improve classification exploiting different aspects, such as using the gradient magnitude for boundary location and statistical, occlusion, or size metrics. In this paper, we present a novel transfer function method which can provide more specificity for data classification by combining different transfer function spaces. In this work, a 2D transfer function can be combined with 1D transfer functions which improve the classification. Specifically, we use the traditional 2D scalar/gradient magnitude, 2D statistical, and 2D occlusion spectrum transfer functions and combine these with occlusion and/or size-based transfer functions to provide better specificity. We demonstrate the usefulness of the new method by comparing to the following previous techniques: 2D gradient magnitude, 2D occlusion spectrum, 2D statistical transfer functions and 2D size based transfer functions. © 2012 Elsevier Ltd.

  7. The pre-trial procedures and principles of the International Criminal ...

    African Journals Online (AJOL)

    Following the heinous cruelties perpetuated by the Nazi regime during the World War II, the world was baffled by the expanse of brutality human beings could commit against one another. However, there was absence of a universal acceptable international criminal procedural structure to try perpetrators of the atrocities.

  8. Custody or release: problem GHB users in police cells, custody, and pre-trial detention

    NARCIS (Netherlands)

    Korf, D.J.; Nabben, T.; Pronk, A.

    2013-01-01

    Gamma-hydroxybutyrate acid (GHB) is a potent depressant of the central nervous system which rapidly enters the bloodstream and produces its effects shortly after ingestion.1 Since the early 1990’s, GHB increasingly became popular as recreational drug, mainly as ‘club drug’, but GHB cannot be

  9. Child court hearings in family cases: Assessment questionnaire of child needs during pre-trial proceedings

    Directory of Open Access Journals (Sweden)

    Asuncion Molina

    2011-01-01

    Full Text Available The basis of family law is the child’s interest. This is related to the right to be listened to, but not as an obligation. As a consequence, there is a necessity for the judge to conduct a judicial exploration of the child. But, in general, the judges are not trained in this type of explorations, and they may consequently obtain erroneous information in their exploration. Therefore, in this work, we present the generation of a questionnaire that explores the judicial agents’ necessities during judicial exploration of children. Five expert researchers in the subject participated in creating the questionnaire; five family judges participated in the pilot test; and in the final study, 63 family judges answered the final questionnaire. Global reliability was adequate (.858, as was the reliability for interviewer’s skills, but it was not for the other areas of the questionnaire. An exploratory factor analysis showed a factor structure consisting of 5 factors that accounted for 46.12% of the total variance, but these five factors don’t correspond to the factors provided by experts. But construct validity validated the structure provided by the experts (2/df = 1.35; BBNNFI = .873; CFI = .879; IFI = .881; RMR = .139; SRMR = .153; RMSEA = .075. To sum up, we can say that the questionnaire could be improved, but the best areas are the stages of the interview and the interviewer’s skills.

  10. Pre-trial agreement and plea bargain: pragmatism without conflict with morality?

    OpenAIRE

    Rodin V.V.; Yadzhin N.V.

    2014-01-01

    A comparative legal analysis of plea bargain in the continental Europe, England and the USA is conducted. The history of the plea bargain emergence in common law is examined, its features are shown. Such agreements to plead guilty are often reached after bringing a charge. The freedom of agreement is guaranteed by the powers of police, court and public prosecutor to decide on the severity of the charge, its change or dismissal (partial or complete). An obvious “conflict of interests” is shown...

  11. Combine Harvester Simulator

    DEFF Research Database (Denmark)

    Vilmann, Ole; Sørlie, James Arnold

    1999-01-01

    A simulator for training pilots in the operation of a modern high-tech combine harvester is presented. The new simulator application is based on DMI´s well-known DMS maritime simulator architecture. Two major challenges have been encountered in the development of the simulator: 1) interfacing...... the simulator software and the harvester hardware, and 2) the visual image generation system. Aims of the project have been to promote technology transfer from DMI´s maritime simulator to new application areas, to develop a state-of-the-art pilot training environment, and to utilise the state...

  12. Structural load combinations

    International Nuclear Information System (INIS)

    Hwang, H.; Reich, M.; Ellingwood, B.; Shinozuka, M.

    1985-01-01

    This paper presents the latest results of the program entitled, ''Probability Based Load Combinations For Design of Category I Structures''. In FY 85, a probability-based reliability analysis method has been developed to evaluate safety of shear wall structures. The shear walls are analyzed using stick models with beam elements and may be subjected to dead load, live load and in-plane eqrthquake. Both shear and flexure limit states are defined analytically. The limit state probabilities can be evaluated on the basis of these limit states. Utilizing the reliability analysis method mentioned above, load combinations for the design of shear wall structures have been established. The proposed design criteria are in the load and resistance factor design (LRFD) format. In this study, the resistance factors for shear and flexure and load factors for dead and live loads are preassigned, while the load factor for SSE is determined for a specified target limit state probability of 1.0 x 10 -6 or 1.0 x 10 -5 during a lifetime of 40 years. 23 refs., 9 tabs

  13. MODELING COMBINING TAX REGIMES

    Directory of Open Access Journals (Sweden)

    Prishchenko E. A.

    2016-03-01

    Full Text Available The article discusses the combination of tax regimes as a result of separation from the operating business of the revenues and costs for system of a united tax on imputed income (UTII with the analysis of the tax consequences of such allocation. Three models of taxation were built: both variants of the simplified system of taxation from UTII and common system of taxation with UTII. We propose a rapid method of the most preferred system of taxation for small businesses’ selection depending material to labor costs ratio. All these results could be implemented in the case when the company starts a new type of activity under the rules UTII, and solves the problem in the framework of the tax regime to conduct this activity - UTII applied or not, based on the criterion of tax savings. Using the relations describing the tax burden when combined tax regimes, we can determine what the yield should have a new business line and what cost structure should it have to reduce the tax burden. The main result is proposed approach that can be used as a tool of tax planning activities of small businesses.

  14. National total survey of German adolescent suicide in prison.

    Science.gov (United States)

    Radeloff, D; Lempp, T; Herrmann, E; Kettner, M; Bennefeld-Kersten, K; Freitag, C M

    2015-02-01

    Incarcerated adolescents are a high-risk group for suicidal behaviour, but data on completed suicide are scarce in this population. The present study aimed at calculating relative risks (RR) of suicide in detention and identifying age-related risk factors. We compared data of a German national total survey of completed suicide of young detainees (14 to suicide deaths in non-incarcerated adolescents (N = 3,484) and incarcerated adults (N = 781). Prison suicide accounted for 2.3% of all suicide deaths in adolescents, but only 0.1% of this age group was detained. The RR = 23.0 for adolescent suicide in detention exceeded the RR = 7.7 of adults by far. In adults, suicide rates in pre-trial detention was fivefold higher than in criminal detention; suicide rates were more balanced in adolescent detainees. Our results underline the need for age-specific suicide prevention strategies in detention.

  15. Combining classical metrology models

    Directory of Open Access Journals (Sweden)

    Francisco Roldán

    2013-11-01

    Full Text Available The results obtained in the graphic analysis of the modulation of the Cuarto Real de Santo Domingo building in Granada, Spain, (ROLDÁN, 2011 have provided new insights to further approach the research on possible use the double-scale in historical monumental architecture. We propose the characterization of the singularities of the system, from the implications and graphic representation required by the metrological scheme identified, as well as the variety of typologies that are presented in their modular frames, and the iterative combination of two-scale modules which allow operational approximations to fractions and ratios not explicitly present in the system.

  16. Combined Heat and Power

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    At their 2007 Summit in Heiligendamm, G8 leaders called on countries to 'adopt instruments and measures to significantly increase the share of combined heat and power (CHP) in the generation of electricity.' As a result, energy, economic, environmental and utility regulators are looking for tools and information to understand the potential of CHP and to identify appropriate policies for their national circumstances. This report forms the first part of the response. It includes answers to policy makers' questions about the potential economic, energy and environmental benefits of an increased policy commitment to CHP. It also includes for the first time integrated IEA data on global CHP installations, and analyses the benefits of increased CHP investment in the G8+5 countries. A companion report will be produced later in 2008 to document best practice policy approaches that have been used to expand the use of CHP in a variety of countries.

  17. Biomass Gasification Combined Cycle

    Energy Technology Data Exchange (ETDEWEB)

    Judith A. Kieffer

    2000-07-01

    Gasification combined cycle continues to represent an important defining technology area for the forest products industry. The ''Forest Products Gasification Initiative'', organized under the Industry's Agenda 2020 technology vision and supported by the DOE ''Industries of the Future'' program, is well positioned to guide these technologies to commercial success within a five-to ten-year timeframe given supportive federal budgets and public policy. Commercial success will result in significant environmental and renewable energy goals that are shared by the Industry and the Nation. The Battelle/FERCO LIVG technology, which is the technology of choice for the application reported here, remains of high interest due to characteristics that make it well suited for integration with the infrastructure of a pulp production facility. The capital cost, operating economics and long-term demonstration of this technology area key input to future economically sustainable projects and must be verified by the 200 BDT/day demonstration facility currently operating in Burlington, Vermont. The New Bern application that was the initial objective of this project is not currently economically viable and will not be implemented at this time due to several changes at and around the mill which have occurred since the inception of the project in 1995. The analysis shows that for this technology, and likely other gasification technologies as well, the first few installations will require unique circumstances, or supportive public policies, or both to attract host sites and investors.

  18. Defining combined immunodeficiency.

    Science.gov (United States)

    Roifman, Chaim M; Somech, Raz; Kavadas, Fotini; Pires, Linda; Nahum, Amit; Dalal, Ilan; Grunebaum, Eyal

    2012-07-01

    Although the extreme condition of typical profound T-cell dysfunction (TD), severe combined immunodeficiency (SCID), has been carefully defined, we are currently in the process of better defining less typical T-cell deficiencies, which tend to present with autologous circulating T-cell combined immunodeficiency (CID). Because autologous cells might interfere with the outcome of bone marrow transplantation, protocols usually include conditioning regimens. Therefore it is important to define the numbers of autologous cells usually detected in patients with CID versus those with SCID. We sought to determine the number of circulating T cells in patients with SCID as opposed to those with CID, to study their function, and to evaluate their possible detection during newborn screening using T-cell receptor excision circle (TREC) analysis. Numbers of circulating CD3(+) T cells (as determined by means of flow cytometry), in vitro responses to PHA, and TREC levels, all measured at presentation, were compiled from the research charts of the entire cohort of patients followed prospectively for T-cell immunodeficiency at the Hospital for Sick Children. Clinical data were ascertained retrospectively from the patient's hospital charts. One hundred three patients had CD3(+) determinations, and 80 of them had a genetic diagnosis. All patients considered to have typical SCID had CD3(+) T-cell counts of fewer than 500 cells/μL. Some variability was observed among different genotypes. In vitro responses to PHA were recorded in 88 patients, of whom 68 had a genetic diagnosis. All patients with low CD3(+) T-cell numbers (<500 cells/μL) also had markedly decreased responses to PHA (typical SCIDs). However, responses ranged widely in the groups of patients with TD who had more than 500 CD3(+) autologous circulating T cells per microliter. Although patients with Omenn syndrome and ζ chain-associated protein, 70 kDa (ZAP70), and purine nucleoside phosphorylase (PNP) deficiencies had low

  19. Combined dyslipidemia in childhood.

    Science.gov (United States)

    Kavey, Rae-Ellen W

    2015-01-01

    Combined dyslipidemia (CD) is now the predominant dyslipidemic pattern in childhood, characterized by moderate-to-severe elevation in triglycerides and non-high-density lipoprotein cholesterol (non-HDL-C), minimal elevation in low-density lipoprotein cholesterol (LDL-C), and reduced HDL-C. Nuclear magnetic resonance spectroscopy shows that the CD pattern is represented at the lipid subpopulation level as an increase in small, dense LDL and in overall LDL particle number plus a reduction in total HDL-C and large HDL particles, a highly atherogenic pattern. In youth, CD occurs almost exclusively with obesity and is highly prevalent, seen in more than 40% of obese adolescents. CD in childhood predicts pathologic evidence of atherosclerosis and vascular dysfunction in adolescence and young adulthood, and early clinical cardiovascular events in adult life. There is a tight connection between CD, visceral adiposity, insulin resistance, nonalcoholic fatty liver disease, and the metabolic syndrome, suggesting an integrated pathophysiological response to excessive weight gain. Weight loss, changes in dietary composition, and increases in physical activity have all been shown to improve CD significantly in children and adolescents in short-term studies. Most importantly, even small amounts of weight loss are associated with significant decreases in triglyceride levels and increases in HDL-C levels with improvement in lipid subpopulations. Diet change focused on limitation of simple carbohydrate intake with specific elimination of all sugar-sweetened beverages is very effective. Evidence-based recommendations for initiating diet and activity change are provided. Rarely, drug therapy is needed, and the evidence for drug treatment of CD in childhood is reviewed. Copyright © 2015 National Lipid Association. Published by Elsevier Inc. All rights reserved.

  20. LIDAR COMBINED SCANNING UNIT

    Directory of Open Access Journals (Sweden)

    V. V. Elizarov

    2016-11-01

    Full Text Available Subject of Research. The results of lidar combined scanning unit development for locating leaks of hydrocarbons are presented The unit enables to perform high-speed scanning of the investigated space in wide and narrow angle fields. Method. Scanning in a wide angular field is produced by one-line scanning path by means of the movable aluminum mirror with a frequency of 20Hz and amplitude of 20 degrees of swing. Narrowband scanning is performed along a spiral path by the deflector. The deflection of the beam is done by rotation of the optical wedges forming part of the deflector at an angle of ±50. The control function of the scanning node is performed by a specialized software product written in C# programming language. Main Results. This scanning unit allows scanning the investigated area at a distance of 50-100 m with spatial resolution at the level of 3 cm. The positioning accuracy of the laser beam in space is 15'. The developed scanning unit gives the possibility to browse the entire investigated area for the time not more than 1 ms at a rotation frequency of each wedge from 50 to 200 Hz. The problem of unambiguous definition of the beam geographical coordinates in space is solved at the software level according to the rotation angles of the mirrors and optical wedges. Lidar system coordinates are determined by means of GPS. Practical Relevance. Development results open the possibility for increasing the spatial resolution of scanning systems of a wide range of lidars and can provide high positioning accuracy of the laser beam in space.

  1. Combining Evidence from Homologous Datasets

    National Research Council Canada - National Science Library

    Feng, Ao; Allan, James

    2006-01-01

    .... We argue that combining evidence from these "homologous" datasets can give us better representation of the original data, and our experiments show that a model combining all sources outperforms each...

  2. Conceptual Combination During Sentence Comprehension

    Science.gov (United States)

    Swinney, David; Love, Tracy; Walenski, Matthew; Smith, Edward E.

    2008-01-01

    This experiment examined the time course of integration of modifier-noun (conceptual) combinations during auditory sentence comprehension using cross-modal lexical priming. The study revealed that during ongoing comprehension, there is initial activation of features of the noun prior to activation of (emergent) features of the entire conceptual combination. These results support compositionality in conceptual combination; that is, they indicate that features of the individual words constituting a conceptual combination are activated prior to combination of the words into a new concept. PMID:17576278

  3. Combining Narrative and Numerical Simulation

    DEFF Research Database (Denmark)

    Hansen, Mette Sanne; Ladeby, Klaes Rohde; Rasmussen, Lauge Baungaard

    2011-01-01

    Strategic simulation is the combination of narrative and numerical simulation and can be used as a tool to support strategic decision making by providing different scenarios in combination with computer modelling. The core of the combined simulation approach (CSA) is to make it possible for decis......Strategic simulation is the combination of narrative and numerical simulation and can be used as a tool to support strategic decision making by providing different scenarios in combination with computer modelling. The core of the combined simulation approach (CSA) is to make it possible...... to the decision making in operations and production management by providing new insights into modelling and simulation based on the combined narrative and numerical simulation approach as a tool for strategy making. The research question asks, “How can the CSA be applied in a practical context to support strategy...

  4. DURABLE RESPONSE OF SPINAL CHORDOMA TO COMBINED INHIBITION OF IGF-1R AND EGFR

    Directory of Open Access Journals (Sweden)

    Tamara eAleksic

    2016-05-01

    Full Text Available Chordomas are rare primary malignant bone tumors arising from embryonal notochord remnants of the axial skeleton. Chordomas commonly recur following surgery and radiotherapy, and there is no effective systemic therapy. Previous studies implicated receptor tyrosine kinases including epidermal growth factor receptor (EGFR and type 1 insulin-like growth factor receptor (IGF-1R in chordoma biology. We report an adult female patient who presented in 2003 with spinal chordoma, treated with surgery and radiotherapy. She underwent further surgery for recurrent chordoma in 2008, with subsequent progression in pelvic deposits. In June 2009 she was recruited onto the Phase I OSI-906-103 trial of EGFR inhibitor erlotinib with linsitinib, a novel inhibitor of IGF-1R/insulin receptor (INSR. Treatment with 100mg QD erlotinib and 50mg QD linsitinib was well-tolerated, and after 18 months a partial response was achieved by RECIST criteria. From 43 months a protocol modification allowed intra-patient linsitinib dose-escalation to 50mg BID. The patient remained stable on trial treatment for a total of five years, discontinuing treatment in August 2014. She subsequently experienced further disease progression for which she underwent pelvic surgery in April 2015. Analysis of DNA extracted from 2008 (pre-trial tissue showed that the tumor harbored wild-type EGFR, and a PIK3CA mutation was detected in plasma but not tumor DNA. The 2015 (post-trial tumor harbored a mutation of uncertain significance in ATM, with no detectable mutations in other components of a 50 gene panel including EGFR, PIK3CA and TP53. By immunohistochemistry the tumor was positive for brachyury, the molecular hallmark of chordoma, and showed weak-moderate membrane and cytoplasmic EGFR. IGF-1R was detected in the plasma membrane and cytoplasm and was expressed more strongly in recurrent tumor than the primary. We also noted heterogeneous nuclear IGF-1R, which has been linked with sensitivity to IGF

  5. Durable Response of Spinal Chordoma to Combined Inhibition of IGF-1R and EGFR.

    Science.gov (United States)

    Aleksic, Tamara; Browning, Lisa; Woodward, Martha; Phillips, Rachel; Page, Suzanne; Henderson, Shirley; Athanasou, Nicholas; Ansorge, Olaf; Whitwell, Duncan; Pratap, Sarah; Hassan, A Bassim; Middleton, Mark R; Macaulay, Valentine M

    2016-01-01

    Chordomas are rare primary malignant bone tumors arising from embryonal notochord remnants of the axial skeleton. Chordomas commonly recur following surgery and radiotherapy, and there is no effective systemic therapy. Previous studies implicated receptor tyrosine kinases, including epidermal growth factor receptor (EGFR) and type 1 insulin-like growth factor receptor (IGF-1R), in chordoma biology. We report an adult female patient who presented in 2003 with spinal chordoma, treated with surgery and radiotherapy. She underwent further surgery for recurrent chordoma in 2008, with subsequent progression in pelvic deposits. In June 2009, she was recruited onto the Phase I OSI-906-103 trial of EGFR inhibitor erlotinib with linsitinib, a novel inhibitor of IGF-1R/insulin receptor (INSR). Treatment with 100 mg QD erlotinib and 50 mg QD linsitinib was well-tolerated, and after 18 months a partial response was achieved by RECIST criteria. From 43 months, a protocol modification allowed intra-patient linsitinib dose escalation to 50 mg BID. The patient remained stable on trial treatment for a total of 5 years, discontinuing treatment in August 2014. She subsequently experienced further disease progression for which she underwent pelvic surgery in April 2015. Analysis of DNA extracted from 2008 (pre-trial) tissue showed that the tumor harbored wild-type EGFR, and a PIK3CA mutation was detected in plasma, but not tumor DNA. The 2015 (post-trial) tumor harbored a mutation of uncertain significance in ATM, with no detectable mutations in other components of a 50 gene panel, including EGFR, PIK3CA, and TP53. By immunohistochemistry, the tumor was positive for brachyury, the molecular hallmark of chordoma, and showed weak-moderate membrane and cytoplasmic EGFR. IGF-1R was detected in the plasma membrane and cytoplasm and was expressed more strongly in recurrent tumor than the primary. We also noted heterogeneous nuclear IGF-1R, which has been linked with sensitivity

  6. Packet reversed packet combining scheme

    International Nuclear Information System (INIS)

    Bhunia, C.T.

    2006-07-01

    The packet combining scheme is a well defined simple error correction scheme with erroneous copies at the receiver. It offers higher throughput combined with ARQ protocols in networks than that of basic ARQ protocols. But packet combining scheme fails to correct errors when the errors occur in the same bit locations of two erroneous copies. In the present work, we propose a scheme that will correct error if the errors occur at the same bit location of the erroneous copies. The proposed scheme when combined with ARQ protocol will offer higher throughput. (author)

  7. Combined Environment Acoustic Chamber (CEAC)

    Data.gov (United States)

    Federal Laboratory Consortium — Purpose: The CEAC imposes combined acoustic, thermal and mechanical loads on aerospace structures. The CEAC is employed to measure structural response and determine...

  8. Symbol Stream Combining Versus Baseband Combining for Telemetry Arraying

    Science.gov (United States)

    Divsalar, D.

    1983-01-01

    The objectives of this article are to investigate and analyze the problem of combining symbol streams from many Deep Space Network stations to enhance bit signal-to-noise ratio and to compare the performance of this combining technique with baseband combining. Symbol stream combining (SSC) has some advantages and some disadvantages over baseband combining (BBC). The SSC suffers almost no loss in combining the digital data and no loss due to the transmission of the digital data by microwave links between the stations. The BBC suffers 0.2 dB loss due to alignment and combining the IF signals and 0.2 dB loss due to transmission of signals by microwave links. On the other hand, the losses in the subcarrier demodulation assembly (SDA) and in the symbol synchronization assembly (SSA) for SSC are more than the losses in the SDA and SSA for BBC. It is shown that SSC outperforms BBC by about 0.35 dB (in terms of the required bit energy-to-noise spectral density for a bit error rate of 1,000) for an array of three DSN antennas, namely 64 m, 34m(T/R) and 34m(R).

  9. Revised Accounting for Business Combinations

    Science.gov (United States)

    Wilson, Arlette C.; Key, Kimberly

    2008-01-01

    The Financial Accounting Standards Board (FASB) has recently issued Statement of Financial Accounting Standards No. 141 (Revised 2007) Business Combinations. The object of this Statement is to improve the relevance, representational faithfulness, and comparability of reported information about a business combination and its effects. This Statement…

  10. Combination contraceptives: effects on weight.

    Science.gov (United States)

    Gallo, Maria F; Lopez, Laureen M; Grimes, David A; Carayon, Florence; Schulz, Kenneth F; Helmerhorst, Frans M

    2014-01-29

    Weight gain is often considered a side effect of combination hormonal contraceptives, and many women and clinicians believe that an association exists. Concern about weight gain can limit the use of this highly effective method of contraception by deterring the initiation of its use and causing early discontinuation among users. However, a causal relationship between combination contraceptives and weight gain has not been established. The aim of the review was to evaluate the potential association between combination contraceptive use and changes in weight. In November 2013, we searched the computerized databases CENTRAL (The Cochrane Library), MEDLINE, POPLINE, EMBASE, and LILACS for studies of combination contraceptives, as well as ClinicalTrials.gov and International Clinical Trials Registry Platform (ICTRP). For the initial review, we also wrote to known investigators and manufacturers to request information about other published or unpublished trials not discovered in our search. All English-language, randomized controlled trials were eligible if they had at least three treatment cycles and compared a combination contraceptive to a placebo or to a combination contraceptive that differed in drug, dosage, regimen, or study length. All titles and abstracts located in the literature searches were assessed. Data were entered and analyzed with RevMan. A second author verified the data entered. For continuous data, we calculated the mean difference and 95% confidence interval (CI) for the mean change in weight between baseline and post-treatment measurements using a fixed-effect model. For categorical data, such as the proportion of women who gained or lost more than a specified amount of weight, the Peto odds ratio with 95% CI was calculated. We found 49 trials that met our inclusion criteria. The trials included 85 weight change comparisons for 52 distinct contraceptive pairs (or placebos). The four trials with a placebo or no intervention group did not find

  11. Combination treatment of neuropathic pain

    DEFF Research Database (Denmark)

    Holbech, Jakob Vormstrup; Jung, Anne; Jonsson, Torsten

    2017-01-01

    , but combination therapy had not been included in guidelines until recently. Based on clinical empiricism and scientific evidence, a Delphi consensus process provided a consolidated guidance on pharmacological combination treatment of NeP. METHODS: A two-round virtual internet-based Delphi process with 6 Danish...... pain specialists was undertaken. In the first round, questions were answered individually and anonymously, whereas in the second round, the panel openly discussed first round's summary of outcomes. Combinations of pharmacological pain treatments, that is, pregabalin/gabapentin, TCAs, serotonin...

  12. Autonomous grain combine control system

    Science.gov (United States)

    Hoskinson, Reed L.; Kenney, Kevin L.; Lucas, James R.; Prickel, Marvin A.

    2013-06-25

    A system for controlling a grain combine having a rotor/cylinder, a sieve, a fan, a concave, a feeder, a header, an engine, and a control system. The feeder of the grain combine is engaged and the header is lowered. A separator loss target, engine load target, and a sieve loss target are selected. Grain is harvested with the lowered header passing the grain through the engaged feeder. Separator loss, sieve loss, engine load and ground speed of the grain combine are continuously monitored during the harvesting. If the monitored separator loss exceeds the selected separator loss target, the speed of the rotor/cylinder, the concave setting, the engine load target, or a combination thereof is adjusted. If the monitored sieve loss exceeds the selected sieve loss target, the speed of the fan, the size of the sieve openings, or the engine load target is adjusted.

  13. Combining Gamification with Big Data

    OpenAIRE

    Godinho, Roger Alan Mateus

    2014-01-01

    This dissertation aims to understand if there is an impact of Gamification and Big Data Technologies combination on the strategy of companies. In order to study this, the present dissertation tests if the benefits raised by the combination of the two creates value to the final users, and moreover, if it can become a sustainable competitive advantage. For this, a research model is developed, where 5 companies that are already introducing such a strategy are analyzed, as well as the Gamificatio...

  14. Combined radar and telemetry system

    Energy Technology Data Exchange (ETDEWEB)

    Rodenbeck, Christopher T.; Young, Derek; Chou, Tina; Hsieh, Lung-Hwa; Conover, Kurt; Heintzleman, Richard

    2017-08-01

    A combined radar and telemetry system is described. The combined radar and telemetry system includes a processing unit that executes instructions, where the instructions define a radar waveform and a telemetry waveform. The processor outputs a digital baseband signal based upon the instructions, where the digital baseband signal is based upon the radar waveform and the telemetry waveform. A radar and telemetry circuit transmits, simultaneously, a radar signal and telemetry signal based upon the digital baseband signal.

  15. Food irradiation and combination processes

    International Nuclear Information System (INIS)

    Campbell-Platt, G.; Grandison, A.S.

    1990-01-01

    International approval of food irradiation is being given for the use of low and medium doses. Uses are being permitted for different categories of foods with maximum levels being set between 1 and 10 kGy. To maximize the effectiveness of these mild irradiation treatments while minimizing any organoleptic quality changes, combination processes of other technologies with irradiation will be useful. Combinations most likely to be exploited in optimal food processing include the use of heat, low temperature, and modified-atmosphere packaging. Because irradiation does not have a residual effect, the food packaging itself becomes an important component of a successful process. These combination processes provide promising alternatives to the use of chemical preservatives or harsher processing techniques. (author)

  16. Mode Combinations and International Operations

    DEFF Research Database (Denmark)

    Benito, Gabriel R. G.; Petersen, Bent; Welch, Lawrence S.

    2011-01-01

    An enduring characteristic of extant literature on foreign operation modes is its discrete choice approach, where companies are assumed to choose one among a small number of distinctive alternatives. In this paper we use detailed information about the operations of six Norwegian companies in three...... key markets (China, UK and USA) as the basis for an exploration of the extent to which, and how and why, companies combine clearly different foreign operation modes. We examine their use of foreign operation mode combinations within given value activities as well as within given countries. The study...... reveals that companies tend to combine modes of operation; thereby producing unique foreign operation mode “packages” for given activities and/or countries, and that the packages are liable to be modified over time – providing a potentially important optional path for international expansion. Our data...

  17. Mode Combinations and International Operations

    DEFF Research Database (Denmark)

    Benito, Gabriel R. G.; Petersen, Bent; Welch, Lawrence S.

    2011-01-01

    An enduring characteristic of extant literature on foreign operation modes is its discrete choice approach, where companies are assumed to choose one among a small number of distinctive alternatives. In this paper, detailed information about the operations of six Norwegian companies in three key...... markets (China, UK and USA) is used as the basis for an exploration of the extent to which, and how and why, companies combine clearly different foreign operation modes. We examine their use of foreign operation mode combinations within given value activities as well as within given countries. The study...... reveals that companies tend to combine modes of operation; thereby producing unique foreign operation mode “packages” for given activities and/or countries, and that the packages are liable to be modified over time—providing a potentially important optional path for international expansion. The data show...

  18. Combination trading with limit orders

    Directory of Open Access Journals (Sweden)

    Henry Schellhorn

    1997-01-01

    Full Text Available We model the exchange of commodities that are contingent upon each other, when traders place mostly limit orders. Examples include: 1 a market of financial futures where future spreads are also traded, 2 a market of mutual funds and stocks, 3 a market of options and stocks, under the viewpoint that they are both combinations of Arrow-Debreu securities. We prove that consistent prices are optimal. We develop a fixed-point algorithm to compute an optimal price and allocation. The algorithm combines ideas from contraction mapping theory and from homotopy theory. It is much faster than a traditional linear programming approach.

  19. Combined oral contraceptives: venous thrombosis.

    Science.gov (United States)

    de Bastos, Marcos; Stegeman, Bernardine H; Rosendaal, Frits R; Van Hylckama Vlieg, Astrid; Helmerhorst, Frans M; Stijnen, Theo; Dekkers, Olaf M

    2014-03-03

    Combined oral contraceptive (COC) use has been associated with venous thrombosis (VT) (i.e., deep venous thrombosis and pulmonary embolism). The VT risk has been evaluated for many estrogen doses and progestagen types contained in COC but no comprehensive comparison involving commonly used COC is available. To provide a comprehensive overview of the risk of venous thrombosis in women using different combined oral contraceptives. Electronic databases (Pubmed, Embase, Web of Science, Cochrane, CINAHL, Academic Search Premier and ScienceDirect) were searched in 22 April 2013 for eligible studies, without language restrictions. We selected studies including healthy women taking COC with VT as outcome. The primary outcome of interest was a fatal or non-fatal first event of venous thrombosis with the main focus on deep venous thrombosis or pulmonary embolism. Publications with at least 10 events in total were eligible. The network meta-analysis was performed using an extension of frequentist random effects models for mixed multiple treatment comparisons. Unadjusted relative risks with 95% confidence intervals were reported.Two independent reviewers extracted data from selected studies. 3110 publications were retrieved through a search strategy; 25 publications reporting on 26 studies were included. Incidence of venous thrombosis in non-users from two included cohorts was 0.19 and 0.37 per 1 000 person years, in line with previously reported incidences of 0,16 per 1 000 person years. Use of combined oral contraceptives increased the risk of venous thrombosis compared with non-use (relative risk 3.5, 95% confidence interval 2.9 to 4.3). The relative risk of venous thrombosis for combined oral contraceptives with 30-35 μg ethinylestradiol and gestodene, desogestrel, cyproterone acetate, or drospirenone were similar and about 50-80% higher than for combined oral contraceptives with levonorgestrel. A dose related effect of ethinylestradiol was observed for gestodene

  20. Combinational processes in uranil structures

    Science.gov (United States)

    Gorelik, V. S.; Korshunov, V. M.; Vodchits, A. I.; Voinov, Yu P.; Loboyko, A. A.

    2017-11-01

    It is established that the photoluminescence spectra of uranyl compounds have a shape of combination bands as equidistant Stokes satellites. These satellites correspond to the transitions from the excited electronic state to the vibrational states of fully-symmetric mode with the frequency of 854 cm-1. The stimulated Raman scattering of light in uranyl compounds is observed when excited by the ultra-short powerful pulses of the laser YAG: Nd3+ (λ=532 nm). The detected combinational processes open the possibility for detecting the uranyl compounds in mixtures and in the environment. The article analyses the conditions for the realization of laser generation in the uranyl compounds.

  1. Self-harm and overcrowding among prisoners in Geneva, Switzerland.

    Science.gov (United States)

    Wolff, Hans; Casillas, Alejandra; Perneger, Thomas; Heller, Patrick; Golay, Diane; Mouton, Elisabeth; Bodenmann, Patrick; Getaz, Laurent

    2016-01-01

    Prison institutional conditions affect risk for self-harm among detainees. In particular, prison overcrowding may increase the likelihood of self-harm by creating competition for resources, space, and enhancing a "deprivation state." The purpose of this paper is to examine the association between overcrowding and prisoner acts of self-harm. This cross-sectional study took place at Geneva's pre-trial prison (capacity:376) between 2006 and 2014. Outcomes were acts of self-harm that required medical attention, and self-strangulation/hanging events (combined into one group, as these are difficult to differentiate). Dichotomous predictors were overcrowding index- annual mean daily population divided by capacity ( > 200 percent vs Overcrowding in excess of 200 percent was associated with self-strangulation/hangings (p overcrowding on prisoner well-being and self-harm potential. The authors observed a significant increase in self-harm and self-strangulation/hangings over time, and overcrowding was significantly associated with self-strangulation/hangings (but not with all self-harm events). Overcrowding can impose destructive effects on the psychological and behavioral well being of inmates in prison, influencing a myriad of emotional and livelihood factors that predispose to harmful behavior. This report should alert public health and prison authorities to this issue, and garner resources to address such an alarming rise. The findings from this short report demonstrate the need for a further examination of the mechanisms affecting self-harm among prisoners in this population, particularly the relationship between self-strangulations/hangings and overcrowding.

  2. SUPPLEMENTARY INFORMATION A combined Electrochemical ...

    Indian Academy of Sciences (India)

    DELL

    A combined Electrochemical and Theoretical study of pyridine-based Schiff bases as novel corrosion inhibitors for mild steel in hydrochloric acid medium. PARUL DOHAREa, M A QURAISHIb* and I B OBOTb. aDepartment of Chemistry, Indian Institute of Technology, Banaras Hindu University, Varanasi, Uttar. Pradesh 221 ...

  3. A Radix-10 Combinational Multiplier

    DEFF Research Database (Denmark)

    Lang, Tomas; Nannarelli, Alberto

    2006-01-01

    reduces the number of partial product precomputations and uses counters to eliminate the need of the decimal equivalent of a 4:2 adder. The results of the implementation show that the combinational decimal multiplier offers a good compromise between latency and area when compared to other decimal multiply...... units and to binary double-precision multipliers....

  4. Turn Continuation and Clause Combinations

    Science.gov (United States)

    Couper-Kuhlen, Elizabeth

    2012-01-01

    This article explores the viability of the analytic distinction between "turn-constructional unit (TCU) continuation" (i.e., continuing a turn beyond a point of possible completion with grammatically dependent material) and "new TCU" (i.e., continuing a turn with grammatically independent material) when hypotactic clause combinations are involved.…

  5. Combined scleral buckling and phacoemulsification

    Directory of Open Access Journals (Sweden)

    Pukhraj Rishi

    2009-01-01

    Conclusion: Combined scleral buckling and phacoemulsification is a safe and effective procedure that spares the patient the burden of repeated surgeries. It may be considered as a treatment option in selected cases of rhegmatogenous retinal detachment with significant cataract with/without early PVR.

  6. Planned combined radiotherapy and surgery

    International Nuclear Information System (INIS)

    Silverman, C.L.; Marks, J.E.

    1987-01-01

    Though the planned combined use of surgery and radiation has been shown to be beneficial for other tumors, the authors feel that the present evidence is far from persuasive in demonstrating a definite superiority of combined therapy over surgery or radiation alone for advanced laryngeal tumors. The actuarial or disease-free survival rates for patients treated with combined therapy have not been significantly increased over those obtained with a single modality in any randomized, well-controlled study, although the trend is toward improved local regional control. Many of the retrospective studies are probably flawed by selection bias; the patients selected for combined treatment generally have more advanced cancers and represent a worse prognostic group. It is clear from this review that the positive value of irradiation for advanced transglottic and supraglottic tumors needs to be documented by a controlled study that compares surgery alone with salvage radiation at time of recurrence to surgery plus adjuvant radiation. The authors feel that such a study is needed to put to rest the present controversy before they can advocate a course of treatment that is expensive, time-consuming, and difficult for the patients to tolerate owing to severe acute side effects and potentially morbid late effects (xerostomia, necrosis) that can greatly lessen the quality of life for these patients

  7. Generalized Boolean Functions as Combiners

    Science.gov (United States)

    2017-06-01

    backbone of many computer functions. Cryptography drives online commerce and allows privileged information safe transit between two parties as well as many...the backbone of many computer functions. Cryptography drives online commerce and allows privileged information safe transit be- tween two parties as...Functions 5 2.1 Linear Feedback Shift Registers . . . . . . . . . . . . . . . . . . 5 2.2 Combiners . . . . . . . . . . . . . . . . . . . . . . . . . . . 8

  8. Binocular combination of luminance profiles.

    Science.gov (United States)

    Ding, Jian; Levi, Dennis M

    2017-11-01

    We develop and test a new two-dimensional model for binocular combination of the two eyes' luminance profiles. For first-order stimuli, the model assumes that one eye's luminance profile first goes through a luminance compressor, receives gain-control and gain-enhancement from the other eye, and then linearly combines the other eye's output profile. For second-order stimuli, rectification is added in the signal path of the model before the binocular combination site. Both the total contrast and luminance energies, weighted sums over both the space and spatial-frequency domains, were used in the interocular gain-control, while only the total contrast energy was used in the interocular gain-enhancement. To challenge the model, we performed a binocular brightness matching experiment over a large range of background and target luminances. The target stimulus was a dichoptic disc with a sharp edge that has an increment or decrement luminance from its background. The disk's interocular luminance ratio varied from trial to trial. To refine the model we tested three luminance compressors, five nested binocular combination models (including the Ding-Sperling and the DSKL models), and examined the presence or absence of total luminance energy in the model. We found that (1) installing a luminance compressor, either a logarithmic luminance function or luminance gain-control, (2) including both contrast and luminance energies, and (3) adding interocular gain-enhancement (the DSKL model) to a combined model significantly improved its performance. The combined model provides a systematic account of binocular luminance summation over a large range of luminance input levels. It gives a unified explanation of Fechner's paradox observed on a dark background, and a winner-take-all phenomenon observed on a light background. To further test the model, we conducted two additional experiments: luminance summation of discs with asymmetric contour information (Experiment 2), similar to

  9. Radiosensitization in combination with hyperthermia

    International Nuclear Information System (INIS)

    Takagi, Miwako

    1987-01-01

    Cell killing efficiency was analysed in the combination of irradiation with hyperthermia using mouse leukemia L1210 cells cultured in suspension. The doubling time of the cells was 17.6 hours. The radiosensitivity of the cells showed 3.5 for the extrapolation number and 0.775 Gy for the mean lethal dose. The thermosensitivity of the cells showed 69.5, 25.5, 4.3 and 3.0 minutes for the mean lethal time for 41, 42, 43 and 44 deg C, respectively. Daily irradiation with 2 Gy or 3 Gy resulted in the plateau survival of 2 x 10 -1 or 2 x 10 -2 after three times of irradiation, and the surviving fraction was not decreased by further irradiation. This might be caused by the partial synchronization of cell cycle at radioresistant phase and by the division inhibition. Daily hyperthermia showed the same trend as the daily irradiation, and did not decrease the surviving fraction efficiently. Daily irradiation combined with hyperthermia twice a week resulted in the effective decrease of the surviving fraction to 1 x 10 -3 after a week. The combination of irradiation with hyperthermia could be effectively applied for the clinical treatment of radioresistant tumors or rapidly growing tumors. (author) 57 refs

  10. Imagining a Stata / Python Combination

    Science.gov (United States)

    Fiedler, James

    2012-01-01

    There are occasions when a task is difficult in Stata, but fairly easy in a more general programming language. Python is a popular language for a range of uses. It is easy to use, has many high ]quality packages, and programs can be written relatively quickly. Is there any advantage in combining Stata and Python within a single interface? Stata already offers support for user-written programs, which allow extensive control over calculations, but somewhat less control over graphics. Also, except for specifying output, the user has minimal programmatic control over the user interface. Python can be used in a way that allows more control over the interface and graphics, and in so doing provide a roundabout method for satisfying some user requests (e.g., transparency levels in graphics and the ability to clear the results window). My talk will explore these ideas, present a possible method for combining Stata and Python, and give examples to demonstrate how this combination might be useful.

  11. Prolonged incarceration and prisoners’ wellbeing: livid experiences of awaiting trial/pre-trial/remand prisoners in Nigeria

    Science.gov (United States)

    Orjiakor, Charles T.; Ugwu, Dorothy I.; Eze, John E.; Ugwu, Leonard I.; Ibeagha, Peace N.; Onu, Desmond U.

    2017-01-01

    ABSTRACT Purpose: Awaiting trial prisoners (ATPs) are represented in prisons globally, and may stay for long periods in detention. This group is however underrepresented in literature on incarcerated persons. We aim to explore the lived experiences of ATPs detained for prolonged years in a sub-Saharan country; examining what they make of their status and how their conditions have affected their wellbeing. Method: Eight inmates awaiting trial for armed robbery and murder offences, held for between 8 years and 15 years participated in a focus group discussion. Hermeneutic phenomenology guided the interpretation of transcripts. Result: ATPs recount disbelief and negative emotional experiences upon incarceration. Alienated and uncertain about their status, ATPs experience intensified distressful ruminations which impact wellbeing. ATPs re-rationalized incarceration and made social comparisons which breed poor perception of self. ATPs nonetheless recounted hopefulness, made favorable comparisons; and find consolation in religious beliefs. Conclusion: Prolonged years spent awaiting trial fuels a deterioration of wellbeing. Alternatives to incarceration are urgently needed for ATPs. Distressful experiences recalled by the inmates beg for the inclusiveness of ATPs in programs that promote wellbeing. The Good Lives Model holds potentials for building an inclusive framework to accommodate ATPs in prison interventions. PMID:29103371

  12. Prolonged incarceration and prisoners' wellbeing: livid experiences of awaiting trial/pre-trial/remand prisoners in Nigeria.

    Science.gov (United States)

    Orjiakor, Charles T; Ugwu, Dorothy I; Eze, John E; Ugwu, Leonard I; Ibeagha, Peace N; Onu, Desmond U

    2017-12-01

    Awaiting trial prisoners (ATPs) are represented in prisons globally, and may stay for long periods in detention. This group is however underrepresented in literature on incarcerated persons. We aim to explore the lived experiences of ATPs detained for prolonged years in a sub-Saharan country; examining what they make of their status and how their conditions have affected their wellbeing. Eight inmates awaiting trial for armed robbery and murder offences, held for between 8 years and 15 years participated in a focus group discussion. Hermeneutic phenomenology guided the interpretation of transcripts. ATPs recount disbelief and negative emotional experiences upon incarceration. Alienated and uncertain about their status, ATPs experience intensified distressful ruminations which impact wellbeing. ATPs re-rationalized incarceration and made social comparisons which breed poor perception of self. ATPs nonetheless recounted hopefulness, made favorable comparisons; and find consolation in religious beliefs. Prolonged years spent awaiting trial fuels a deterioration of wellbeing. Alternatives to incarceration are urgently needed for ATPs. Distressful experiences recalled by the inmates beg for the inclusiveness of ATPs in programs that promote wellbeing. The Good Lives Model holds potentials for building an inclusive framework to accommodate ATPs in prison interventions.

  13. Gaming under pre-trial detention: At-risk youth and their digital leisure practices during remand

    DEFF Research Database (Denmark)

    Nielsen, Rune Kristian; Witkowski, Emma

    This paper looks at the practices of young men engaging with digital leisure activities within the physical, social, and psychological setting of a Danish Juvenile Detention Center. The study of young men's digital play prevails in game studies, yet the experiences and lifestyles captured in over...... experienced? This is the circumstance, which we directly investigate, in this early study: the digital leisure practices of incarcerated at-risk youths who experience boredom as “a part of the walls” of their short-term way of life (Torbenfeldt Bengtsson, 2012). This early study looks at how play and...... of contradictions. A setting where concerns about youth, violence and aggression in games are challenged. A period of time where gaming is a way of harnessing social capital as an alternative to former high-risk or otherwise unlawful endeavors; a situation where “leisure”, detention, and boredom are a framework...

  14. Pre-Trial EEG-based Single-Trial Motor Performance Prediction to Enhance Neuroergonomics for a Hand Force Task

    Directory of Open Access Journals (Sweden)

    Andreas eMeinel

    2016-04-01

    Full Text Available We propose a framework for building electrophysiological predictors of single-trial motor performance variations, exemplified for SVIPT, a sequential isometric force control task suitable for hand motor rehabilitation after stroke.Electroencephalogram (EEG data of 20 subjects with mean age of 53 years was recorded prior to and during 400 trials of SVIPT. They were executed within a single session with the non-dominant left hand, while receiving continuous visual feedback of the produced force trajectories. The behavioral data showed strong trial-by-trial performance variations for five clinically relevant metrics, which accounted for reaction time as well as for the smoothness and precision of the produced force trajectory.18 out of 20 tested subjects remained after preprocessing and entered offline analysis. Source Power Comodulation (SPoC was applied on EEG data of a short time interval prior to the start of each SVIPT trial. For 11 subjects, SPoC revealed robust oscillatory EEG subspace components, whose bandpower activity are predictive for the performance of the upcoming trial. Since SPoC may overfit to non-informative subspaces, we propose to apply three selection criteria accounting for the meaningfulness of the features. Across all subjects, the obtained components were spread along the frequency spectrum and showed a variety of spatial activity patterns. Those containing the highest level of predictive information resided in and close to the alpha band. Their spatial patterns resemble topologies reported for visual attention processes as well as those of imagined or executed hand motor tasks. In summary, we identified subject-specific single predictors that explain up to 36 % of the performance fluctuations and may serve for enhancing neuroergonomics of motor rehabilitation scenarios.

  15. [Combination chemotherapy of experimental leukemia].

    Science.gov (United States)

    Emanuel', N M; Konovalova, N P; D'iachkovskaia, R F

    1977-01-01

    In the present work an attempt was made to gain greater therapeutic effect of diazane coupled with adriamycin and sarcolysin. Leucemias L-1210 and La served as a model. In leucosis La diazane was injected once in 5 days. Either an additional injection of adriamycin two days prior to diazane injection or sarcolysin injected simultaneously with diazane enabled the authors to obtain a distinct synergestic effect. In leucemia L-1210 a simultaneous administration of diazane and sarcolysin also contributes to considerably longer survival of leucemic animals. Such combinations are likely to be promising in their clinical use.

  16. Chemical and natural stressors combined:

    DEFF Research Database (Denmark)

    Gergs, André; Zenker, Armin; Grimm, Volker

    2013-01-01

    In addition to natural stressors, populations are increasingly exposed to chemical pollutants released into the environment. We experimentally demonstrate the loss of resilience for Daphnia magna populations that are exposed to a combination of natural and chemical stressors even though effects...... vulnerability to the toxicant which acts in a size selective manner. Moreover, population vulnerability to the toxicant increases with predator size and predation intensity whereas indirect trait-mediated interactions via predator kairomones may buffer chemical effects to a certain extent. Our study...... demonstrates that population size can be a poor endpoint for risk assessments of chemicals and that ignoring disturbance interactions can lead to severe underestimation of extinction risk...

  17. Combining Alphas via Bounded Regression

    Directory of Open Access Journals (Sweden)

    Zura Kakushadze

    2015-11-01

    Full Text Available We give an explicit algorithm and source code for combining alpha streams via bounded regression. In practical applications, typically, there is insufficient history to compute a sample covariance matrix (SCM for a large number of alphas. To compute alpha allocation weights, one then resorts to (weighted regression over SCM principal components. Regression often produces alpha weights with insufficient diversification and/or skewed distribution against, e.g., turnover. This can be rectified by imposing bounds on alpha weights within the regression procedure. Bounded regression can also be applied to stock and other asset portfolio construction. We discuss illustrative examples.

  18. Why the Combined Field Army?

    Science.gov (United States)

    1989-03-31

    COMBINED FIELD ARMY A September 1988 article in the Wall Street Journal points out the arenas of change underway on the Korean peninsula.16 Many important...with superior results. ENDNOTES 16. Susan Moffat, "Koreans Demanding Equality on Defense", The Wall Street Journal ., 28 September 1988,p20. 17. This...p46. 20. Roh Address, p6. 21. Susan Moffat, " In Korea, Reunification is a Family Matter", The Wall Street Journal , 23 January 1989, pAl0. 22. Bunge

  19. [Familial combined hyperlipidemia: consensus document].

    Science.gov (United States)

    Mata, Pedro; Alonso, Rodrigo; Ruíz-Garcia, Antonio; Díaz-Díaz, Jose L; González, Noemí; Gijón-Conde, Teresa; Martínez-Faedo, Ceferino; Morón, Ignacio; Arranz, Ezequiel; Aguado, Rocío; Argueso, Rosa; Perez de Isla, Leopoldo

    2014-10-01

    Familial combined hyperlipidemia (FCH) is a frequent disorder associated with premature coronary artery disease. It is transmitted in an autosomal dominant manner, although there is not a unique gene involved. The diagnosis is performed using clinical criteria, and variability in lipid phenotype and family history of hyperlipidemia are necessaries. Frequently, the disorder is associated with type2 diabetes mellitus, arterial hypertension and central obesity. Patients with FCH are considered as high cardiovascular risk and the lipid target is an LDL-cholesterol <100mg/dL, and <70mg/dL if cardiovascular disease or type 2 diabetes are present. Patients with FCH require lipid lowering treatment using potent statins and sometimes, combined lipid-lowering treatment. Identification and management of other cardiovascular risk factors as type 2 diabetes and hypertension are fundamental to reduce cardiovascular disease burden. This document gives recommendations for the diagnosis and global treatment of patients with FCH directed to specialists and general practitioners. Copyright © 2014 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España. All rights reserved.

  20. Combination therapies in iron chelation

    Directory of Open Access Journals (Sweden)

    Raffaella Origa

    2014-12-01

    Full Text Available The availability of oral iron chelators and new non-invasive methods for early detection and treatment of iron overload, have significantly improved the life expectancy and quality of life of patients with b thalassemia major. However, monotherapy is not effective in all patients for a variety of reasons. We analyzed the most relevant reports recently published on alternating or combined chelation therapies in thalassemia major with special attention to safety aspects and to their effects in terms of reduction of iron overload in different organs, improvement of complications, and survival. When adverse effects, such as gastrointestinal upset with deferasirox or infusional site reactions with deferoxamine are not tolerable and organ iron is in an acceptable range, alternating use of two chelators (drugs taken sequentially on different days, but not taken on the same day together may be a winning choice. The association deferiprone and deferoxamine should be the first choice in case of heart failure and when dangerously high levels of cardiac iron exist. Further research regarding the safety and efficacy of the most appealing combination treatment, deferiprone and deferasirox, is needed before recommendations for routine clinical practice can be made.

  1. 38 CFR 21.124 - Combination course.

    Science.gov (United States)

    2010-07-01

    ... Educational and Vocational Training Services § 21.124 Combination course. (a) General. A combination course is a course which combines training on the job with training in school. For the purpose of VA... pursue the components of a combination course in the following manner: (1) Concurrent school and on-job...

  2. [Risk reduction and drug use in detention: study about the detainees of Liancourt Penitentiary].

    Science.gov (United States)

    Sannier, Olivier; Verfaillie, Florent; Lavielle, Dorothée

    2012-07-01

    The prison population is drug users. Recent debates around the provision of devices to reduce the risks associated with drug use (syringe exchange programs and snort kit) lead us to question local practices of the prison population. An anonymous questionnaire was offered to the prison population of the Liancourt penitentiary. The questions addressed the use of drugs before and during incarceration, knowledge of HIV and B and C hepatitis status, taking an opiate substitution treatment and advice on the implementation of syringe exchange programs and snort kit. A percentage of 54.4 of the prisoners responded to the questionnaire. An amount of 60.1 % of respondents consumed at least one drug before incarceration and 43.6 % of respondents consumed at least one drug during their incarceration. Cannabis was the most consumed drug before and during incarceration. Barely half of respondents reported knowing their HIV and hepatitis B and C status. Over 10 % of respondents said they were interesting in establishing needle exchange programs or snort kit. The prison concentrate drug users and is not a repressive tool of efficient risk reduction. The strategies implemented by the medical unit of Liancourt prison require adaptations that warrant development of health resources. Then, only new tools to reduce risks associated with drug use can be established. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  3. The Role of Open and Distance Higher Education in Detainees in Greek Detention Facilities

    Science.gov (United States)

    Linardatou, Charitini; Manousou, Evangelia

    2015-01-01

    The purpose of this article is to present the results of the qualitative research conducted in Detention Facilities in Greece in connection with the preparation of the thesis (Linardatou, 2012). This is a case study of two prisoners attending Open Universities. The study concerned the characteristics and peculiarities of Open and Distance…

  4. Voyage to the Dark Side: The Tortured Path of United States’ Detainee Interrogation Policy

    Science.gov (United States)

    2007-08-13

    charges in foreign court based upon the principle of “universal jurisdiction”359 and the “ Pinochet Precedent.”360 Augusto Pinochet Ugarte, former...universal jurisdiction in order to indict Pinochet and seek his extradition from the United Kingdom. The court in the United Kingdom rejected Pinochet’s...immunity claims and was prepared to extradite him to Spain. British officials intervened and determined that Pinochet was too ill to be extradited

  5. 'Six Floors' of Detainee Operations in the Post-9/11 World

    National Research Council Canada - National Science Library

    Ayres, Thomas E

    2005-01-01

    .... On the 6th floor are easily identifiable enemy prisoners of war. POWs openly wear the uniform of a power that abides by the laws of war, and are accorded all privileges specified in Geneva III...

  6. Factorized combinations of Virasoro characters

    International Nuclear Information System (INIS)

    Bytsko, A.G.; Fring, A.

    2000-01-01

    We investigate linear combinations of characters for minimal Virasoro models which are representable as a product of several basic blocks. Our analysis is based on consideration of asymptotic behaviour of the characters in the quasi-classical limit. In particular, we introduce a notion of the secondary effective central charge. We find all possible cases for which factorization occurs on the base of the Gauss-Jacobi or the Watson identities. Exploiting these results, we establish various types of identities between different characters. In particular, we present several identities generalizing the Rogers-Ramanujan identities. Applications to quasi-particle representations, modular invariant partition functions, super-conformal theories and conformal models with boundaries are briefly discussed. (orig.)

  7. Combined Shape and Topology Optimization

    DEFF Research Database (Denmark)

    Christiansen, Asger Nyman

    Shape and topology optimization seeks to compute the optimal shape and topology of a structure such that one or more properties, for example stiffness, balance or volume, are improved. The goal of the thesis is to develop a method for shape and topology optimization which uses the Deformable...... Simplicial Complex (DSC) method. Consequently, we present a novel method which combines current shape and topology optimization methods. This method represents the surface of the structure explicitly and discretizes the structure into non-overlapping elements, i.e. a simplicial complex. An explicit surface...... representation usually limits the optimization to minor shape changes. However, the DSC method uses a single explicit representation and still allows for large shape and topology changes. It does so by constantly applying a set of mesh operations during deformations of the structure. Using an explicit instead...

  8. How rats combine temporal cues.

    Science.gov (United States)

    Guilhardi, Paulo; Keen, Richard; MacInnis, Mika L M; Church, Russell M

    2005-05-31

    The procedures for classical and operant conditioning, and for many timing procedures, involve the delivery of reinforcers that may be related to the time of previous reinforcers and responses, and to the time of onsets and terminations of stimuli. The behavior resulting from such procedures can be described as bouts of responding that occur in some pattern at some rate. A packet theory of timing and conditioning is described that accounts for such behavior under a wide range of procedures. Applications include the food searching by rats in Skinner boxes under conditions of fixed and random reinforcement, brief and sustained stimuli, and several response-food contingencies. The approach is used to describe how multiple cues from reinforcers and stimuli combine to determine the rate and pattern of response bouts.

  9. Combined processing of lead concentrates

    Science.gov (United States)

    Kubasov, V. L.; Paretskii, V. M.; Sidorin, G. N.; Travkin, V. F.

    2013-06-01

    A combined scheme of processing of lead concentrates with the production of pure metallic lead and the important components containing in these concentrates is considered. This scheme includes sulfating roasting of the lead concentrates and two-stage leaching of the formed cinder with the formation of a sulfate solution and lead sulfate. When transformed into a carbonate form, lead sulfate is used for the production of pure metallic lead. Silver, indium, copper, cadmium, nickel, cobalt, and other important components are separately extracted from a solution. At the last stage, zinc is extracted by either extraction followed by electrolytic extraction of a metal or the return of the forming solution of sulfuric acid to cinder leaching.

  10. Combining supramolecular chemistry with biology.

    Science.gov (United States)

    Uhlenheuer, Dana A; Petkau, Katja; Brunsveld, Luc

    2010-08-01

    Supramolecular chemistry has primarily found its inspiration in biological molecules, such as proteins and lipids, and their interactions. Currently the supramolecular assembly of designed compounds can be controlled to great extent. This provides the opportunity to combine these synthetic supramolecular elements with biomolecules for the study of biological phenomena. This tutorial review focuses on the possibilities of the marriage of synthetic supramolecular architectures and biological systems. It highlights that synthetic supramolecular elements are for example ideal platforms for the recognition and modulation of proteins and cells. The unique features of synthetic supramolecular systems with control over size, shape, valency, and interaction strength allow the generation of structures fitting the demands to approach the biological problems at hand. Supramolecular chemistry has come full circle, studying the biology and its molecules which initially inspired its conception.

  11. Systemic combination treatment for psoriasis: a review

    DEFF Research Database (Denmark)

    Jensen, Peter; Skov, Lone; Zachariae, Claus

    2010-01-01

    exist for the use of systemic combination therapy. Therefore, our aim was to review the current literature on systemic anti-psoriatic combination regimens. We searched PubMed and identified 98 papers describing 116 studies (23 randomized) reporting on the effect of various systemic combination...... treatments. The most thoroughly investigated combination was retinoid and phototherapy. Further controlled research is needed to define the safest and most effective combination regimens....

  12. Combined chemotherapy of malignant gliomas

    Energy Technology Data Exchange (ETDEWEB)

    Jellinger, K.; Volc, D.; Grisold, W.; Flament, H.; Vollmer, R.; Weiss, R. (Krankenhaus der Stadt Wien-Lainz (Austria). Ludwig Boltzmann Inst. fuer Neurobiologie)

    1983-01-01

    A controlled study of 226 age-matched patients with histologically proven grade 3 and 4 supratentorial gliomas with maximum feasible tumour resection, postoperative Karnofsky performance over 50 and minimum survival of 8 weeks compares the results of supportive care (45 cases), high-dose irradiation of 40 to 66 Gy (59 cases), COMP protocol (CCNU, procarbazine, vincristine, methotrexate, prednisone in 15 day cycles-42 cases) and simultaneous irradiation and COMP chemotherapy (80 cases including 30 survivors). Median recurrent-free intervals in the treatment groups (7 to 11.7 months) were significantly longer than after supportive care (4.4 months). Median survival with supportive care (6.7 months) was significantly shorter than after radiation or COMP treatment (11.7 and 12.3 months) and 14.9 to over 19.9 months with combined treatment, where the two-year survival rates were 33 and 67% (for survivors), and the 3-year survival rates 13 to 30%. Toxic side effects of multimodality treatment were more frequent than after chemotherapy. In addition to space-occupying intracranial cysts often simulating tumour recurrence (12%) and rare radiation necrosis, about 15% of long-term survivors developed progressive intellectual dysfunction with brain atrophy, in the absence of tumour regrowth. Despite some promising results of multimodality approaches towards the management of malignant supratentorial gliomas, the overall results are unsatisfactory and need further optimization.

  13. Severe combined immune deficiency syndrome

    International Nuclear Information System (INIS)

    Saleem, A.F.; Khawaja, R.D.A.; Shaikh, A.S.; Ali, S.A.; Zaidi, A.K.M.

    2013-01-01

    To determine the clinico-demographic features and laboratory parameters of children with severe combined immunodeficiency (SCID). Study Design: Case series. Place and Duration of Study: Department of Paediatrics and Child Health, the Aga Khan University, Karachi, from July 2006 to July 2011. Methodology: Thirteen infants who were discharged with a diagnosis of SCID were inducted in the study. Their clinicodemographic features and laboratory parameters were determined. Descriptive statistics has been used for computing frequency and percentage. Results: The median age at diagnosis was five months; 5 infants presented within 3 months of life. Three-fourth (77%) were males. Most of the infants were severely malnourished (85%) at the time of presentation. More than two-thirds (69%) were products of consanguineous marriages. All subjects had severe lymphopenia (absolute lymphocyte count (ALC) ranging between 170 – 2280) and low T and B lymphocyte counts. Conclusion: SCID should be considered in infants presenting with severe and recurrent infections. Low ALC (< 2500/mm3), is a reliable diagnostic feature of SCID. These infants should be promptly referred to a facility where stem cell transplant can be done. (author)

  14. Efficient Web Services Policy Combination

    Science.gov (United States)

    Vatan, Farrokh; Harman, Joseph G.

    2010-01-01

    Large-scale Web security systems usually involve cooperation between domains with non-identical policies. The network management and Web communication software used by the different organizations presents a stumbling block. Many of the tools used by the various divisions do not have the ability to communicate network management data with each other. At best, this means that manual human intervention into the communication protocols used at various network routers and endpoints is required. Developing practical, sound, and automated ways to compose policies to bridge these differences is a long-standing problem. One of the key subtleties is the need to deal with inconsistencies and defaults where one organization proposes a rule on a particular feature, and another has a different rule or expresses no rule. A general approach is to assign priorities to rules and observe the rules with the highest priorities when there are conflicts. The present methods have inherent inefficiency, which heavily restrict their practical applications. A new, efficient algorithm combines policies utilized for Web services. The method is based on an algorithm that allows an automatic and scalable composition of security policies between multiple organizations. It is based on defeasible policy composition, a promising approach for finding conflicts and resolving priorities between rules. In the general case, policy negotiation is an intractable problem. A promising method, suggested in the literature, is when policies are represented in defeasible logic, and composition is based on rules for non-monotonic inference. In this system, policy writers construct metapolicies describing both the policy that they wish to enforce and annotations describing their composition preferences. These annotations can indicate whether certain policy assertions are required by the policy writer or, if not, under what circumstances the policy writer is willing to compromise and allow other assertions to take

  15. Combination antidepressants - use by GPs and psychiatrists.

    Science.gov (United States)

    Horgan, David; Dodd, Seetal

    2011-06-01

    Current treatment of depression fails to achieve remission in 50% of patients. Combinations of two antidepressants are used by some Australian psychiatrists. This article investigates the pros and cons of combination antidepressant therapy and provides suggestions for when to consider their use, which combinations to choose, and how to introduce combination antidepressant therapies. Combining two antidepressants is a controversial strategy, with supporters and critics arguing its efficacy and safety from opposing perspectives. The use of combination antidepressant therapies may facilitate remission from depression. However, there is limited evidence supporting these treatments, and safety concerns are often cited. There is some support for combination therapies in selected cases from international bodies. After considering risks and benefits on a case-by-case basis, careful use of selected combination antidepressant therapy may be one of a range of effective treatments for some individuals suffering from depression.

  16. 27 CFR 6.93 - Combination packaging.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Combination packaging. 6..., DEPARTMENT OF THE TREASURY LIQUORS âTIED-HOUSEâ Exceptions § 6.93 Combination packaging. The act by an industry member of packaging and distributing distilled spirits, wine, or malt beverages in combination...

  17. Modified function projective combination synchronization of ...

    Indian Academy of Sciences (India)

    2017-02-08

    Feb 8, 2017 ... Abstract. In this work, a novel combination synchronization scheme in which synchronization of a new combination hyperchaotic drive system formed by combining state variables of the original drive system with appropriate scaling factors with a response hyperchaotic system is considered.

  18. Multiswitching combination–combination synchronization of chaotic ...

    Indian Academy of Sciences (India)

    In this paper, a novel synchronization scheme is investigated for a class of chaotic systems. Themultiswitching synchronization scheme is extended to the combination–combination synchronization scheme such that the combination of state variables of two drive systems synchronize with different combination of state ...

  19. HIV and tuberculosis in prisons in sub-Saharan Africa.

    Science.gov (United States)

    Telisinghe, Lilanganee; Charalambous, Salome; Topp, Stephanie M; Herce, Michael E; Hoffmann, Christopher J; Barron, Peter; Schouten, Erik J; Jahn, Andreas; Zachariah, Rony; Harries, Anthony D; Beyrer, Chris; Amon, Joseph J

    2016-09-17

    Given the dual epidemics of HIV and tuberculosis in sub-Saharan Africa and evidence suggesting a disproportionate burden of these diseases among detainees in the region, we aimed to investigate the epidemiology of HIV and tuberculosis in prison populations, describe services available and challenges to service delivery, and identify priority areas for programmatically relevant research in sub-Saharan African prisons. To this end, we reviewed literature on HIV and tuberculosis in sub-Saharan African prisons published between 2011 and 2015, and identified data from only 24 of the 49 countries in the region. Where data were available, they were frequently of poor quality and rarely nationally representative. Prevalence of HIV infection ranged from 2·3% to 34·9%, and of tuberculosis from 0·4 to 16·3%; detainees nearly always had a higher prevalence of both diseases than did the non-incarcerated population in the same country. We identified barriers to prevention, treatment, and care services in published work and through five case studies of prison health policies and services in Zambia, South Africa, Malawi, Nigeria, and Benin. These barriers included severe financial and human-resource limitations and fragmented referral systems that prevent continuity of care when detainees cycle into and out of prison, or move between prisons. These challenges are set against the backdrop of weak health and criminal-justice systems, high rates of pre-trial detention, and overcrowding. A few examples of promising practices exist, including routine voluntary testing for HIV and screening for tuberculosis upon entry to South African and the largest Zambian prisons, reforms to pre-trial detention in South Africa, integration of mental health services into a health package in selected Malawian prisons, and task sharing to include detainees in care provision through peer-educator programmes in Rwanda, Zimbabwe, Zambia, and South Africa. However, substantial additional investments are

  20. Combining or Separating Forward and Reverse Logistics

    DEFF Research Database (Denmark)

    Herbert-Hansen, Zaza Nadja Lee; Larsen, Samuel; Nielsen, Anders

    2017-01-01

    a position between the two extremes. The purpose of this paper is to identify the contextual factors that determine the most advantageous position, which the paper refers to as the most advantageous degree of combination. Design/methodology/approach– The paper first develops a scale ranging from 0......% combination to 100% combination (i.e. full separation). Second, using contingency theory the paper identifies the contextual factors described in RL-literature that determine the most advantageous degree of combination. The set of factors is subsequently tested using a case study, which applies...... a triangulation approach that combines a qualitative and a quantitative method. Findings – Results show six distinct contextual factors that determine the most advantageous degree of combination. Examples of factors are technical product complexity, product portfolio variation, and the loss of product value over...

  1. Imipramine and pregabalin combination for painful polyneuropathy

    DEFF Research Database (Denmark)

    Holbech, Jakob V; Bach, Flemming W; Finnerup, Nanna B

    2015-01-01

    scores than both monotherapies: combination vs imipramine (P = 0.009), combination vs pregabalin (P combination therapy, the dropout rate was higher and the patients reported a higher rate and severity of side effects. Combination of moderate doses of the tricyclic antidepressant......Monotherapy with first-line drugs for neuropathic pain often fails to provide sufficient pain relief or has unacceptable side effects because of the need for high doses. The aim of this trial was to test whether the combination of imipramine and pregabalin in moderate doses would relieve pain more...... effectively than monotherapy with either of the drugs. This was a randomized, double-blind, placebo-controlled, crossover, multicenter trial consisting of four 5-week treatment periods in patients with painful polyneuropathy. Treatment arms were imipramine 75 mg/d vs pregabalin 300 mg/d vs combination therapy...

  2. Systemic combination treatment for psoriasis: a review

    DEFF Research Database (Denmark)

    Jensen, Peter; Skov, Lone; Zachariae, Claus

    2010-01-01

    Psoriasis is a chronic inflammatory skin disease, which affects approximately 2.6% of the population in Northern Europe and Scandinavia. In order to achieve disease control, combinations of systemic treatments are sometimes needed for variable time periods. However, no evidence-based guidelines...... exist for the use of systemic combination therapy. Therefore, our aim was to review the current literature on systemic anti-psoriatic combination regimens. We searched PubMed and identified 98 papers describing 116 studies (23 randomized) reporting on the effect of various systemic combination...... treatments. The most thoroughly investigated combination was retinoid and phototherapy. Further controlled research is needed to define the safest and most effective combination regimens....

  3. Combined eye-atmosphere visibility model

    Science.gov (United States)

    Kaufman, Y. J.

    1981-01-01

    Existing models of the optical characteristics of the eye are combined with a recent model of optical characteristics of the atmosphere given by its modulation transfer function. This combination results in the combined eye-atmosphere performance given by the product of their modulation transfer functions. An application for the calculation of visibility thresholds in the case of a two-halves field is given.

  4. THERAPEUTIC EFFECTS OF COMBINED ORAL CONTRACEPTIVES

    Directory of Open Access Journals (Sweden)

    Роман Андреевич Моргунов

    2017-04-01

    Conclusion: The correct and timely appointment of combined oral contraceptives not only eliminates the risk of unwanted pregnancies, but also provides a therapeutic effect in various gynecological diseases.

  5. 12 CFR 5.33 - Business combinations.

    Science.gov (United States)

    2010-01-01

    ... with safe and sound banking practices. (iii) Money laundering. The OCC considers the effectiveness of any insured depository institution involved in the business combination in combating money laundering...

  6. Multimedia: How to Combine Language and Visuals

    Directory of Open Access Journals (Sweden)

    Holger Horz

    2012-08-01

    Full Text Available In the last decade, advanced computer technology has allowed for development of information systems and learning environments that combine language with other forms of human communication in innovative ways. Language in the form of written texts, for example, can be combined not only with static pictures or graphs as in printed material, but also with animation or video.

  7. Combination proves effective for acute post-

    African Journals Online (AJOL)

    Adele

    operative pain - A meta-analysis of single dose oral tramadol administered in combination with acetaminophen (paracetamol) effect that is greater than either individual component. The combination formulation also had significantly lower NNT. (number-needed-to-treat) than the components alone, compa- rable to ibuprofen ...

  8. Multiswitching combination–combination synchronization of chaotic ...

    Indian Academy of Sciences (India)

    2017-02-09

    Feb 9, 2017 ... Abstract. In this paper, a novel synchronization scheme is investigated for a class of chaotic systems. The multiswitching synchronization scheme is extended to the combination–combination synchronization scheme such that the combination of state variables of two drive systems synchronize with different ...

  9. 7 CFR 29.1008 - Combination symbols.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Combination symbols. 29.1008 Section 29.1008..., 13, 14 and Foreign Type 92) § 29.1008 Combination symbols. A color or group symbol used with another symbol to form the third factor of a grademark to denote a particular side or characteristic of the...

  10. A linear combination of modified Bessel functions

    Science.gov (United States)

    Shitzer, A.; Chato, J. C.

    1971-01-01

    A linear combination of modified Bessel functions is defined, discussed briefly, and tabulated. This combination was found to recur in the analysis of various heat transfer problems and in the analysis of the thermal behavior of living tissue when modeled by cylindrical shells.

  11. Multimedia: How to Combine Language and Visuals

    Directory of Open Access Journals (Sweden)

    Holger Horz

    2008-08-01

    Full Text Available In the last decade, advanced computer technology has allowed for development of information systems and learning environments that combine language with other forms of human communication in innovative ways. Language in the form of written texts, for example, can be combined not only with static pictures or graphs as in printed material, but also with animation or video.

  12. Combined Laparoscopic and Cystoscopic Retrieval of Forgotten ...

    African Journals Online (AJOL)

    cavity with calculus formation around the tail and thread of the IUCD in the urinary bladder causing recurrent urinary tract infection. This “Collar Stud” effect made either cystoscopic or laparoscopic retrieval alone unsuccessful necessitating a combined approach. This case report highlights the need for a combined.

  13. Combining cues while avoiding perceptual conflicts

    NARCIS (Netherlands)

    Hogervorst, M.A.; Brenner, E.

    2004-01-01

    A common assumption in cue combination models is that small discrepancies between cues are due to the limited resolution of the individual cues. Whenever this assumption holds, information from the separate cues can best be combined to give a single, more accurate estimate of the property of

  14. OPTIMIZATION OF COMBINED SEWER OVERFLOW CONTROL SYSTEMS

    Science.gov (United States)

    The highly variable and intermittent pollutant concentrations and flowrates associated with wet-weather events in combined sewersheds necessitates the use of storage-treatment systems to control pollution.An optimized combined-sewer-overflow (CSO) control system requires a manage...

  15. Combine material against electromagnetic pulse disturbance

    International Nuclear Information System (INIS)

    Liu Yan

    2004-01-01

    A novel combined material is introduced, which is hard against electromagnetic pulse disturbance, The attenuation characteristics and the penetration probability of the combine material is discussed in detail. The penetration probability of electromagnetic wave is calculated approximately and the characteristic curve is measured for this material. (authors)

  16. [Combination treatment of hypertension in 2015].

    Science.gov (United States)

    Špinar, Jindřich; Vítovec, Jiří; Špinarová, Lenka; Bendová, Miroslava

    2015-05-01

    We present an overview of the present views on combination treatment and on fixed combinations in the treatment of hypertension according to guidelines of ESH/ESC and ČSH from 2013. The most frequently recommended dual combinations include a blocker of the renin-angiotensin system (ACEI or sartan) and a calcium channel blocker, and further a blocker of the renin-angiotensin system and a diuretic and a calcium channel blocker and a diuretic. In 2014 a fixed-dose combination of an ACE inhibitor (perindopril), a calcium channel blocker (amlodipine) and an diuretic (indapamide) appeared on the Czech market. Within the PIANIST study including 4 731 insufficiently controlled hypertensives, a fixed-dose triple combination of perindopril, amlodipine and indapamide led to a decrease in blood pressure by 28.3/13.8 mm Hg and to a sufficient control of hypertension in 92 % of patients. The advantage of fixed combinations primarily consists in greater compliance of patients and thereby in a better control of hypertension. About 1/3 of hypertensives need a triple combination for a satisfactory blood pressure control.

  17. Crankshaft position sensing with combined starter alternator

    Science.gov (United States)

    Brandenburg, Larry Raymond; Miller, John Michael

    2000-06-13

    A crankshaft position sensing apparatus for use with an engine (16) having a combined starter/alternator assembly (18). The crankshaft position sensing apparatus includes a tone ring (38) with a sensor (36) and bandpass filter (46), having a cylinder identification input from a camshaft sensor (48), and a gain limiter (54). The sensing apparatus mounts near the rotor (30) of the combined starter/alternator assembly (18). The filtered crankshaft position signal can then be input into a vehicle system controller (58) and an inner loop controller (60). The starter/alternator assembly (18) in combination with an internal combustion engine is particularly useful for a hybrid electric vehicle system.

  18. Combination solar photovoltaic heat engine energy converter

    Science.gov (United States)

    Chubb, Donald L.

    1987-01-01

    A combination solar photovoltaic heat engine converter is proposed. Such a system is suitable for either terrestrial or space power applications. The combination system has a higher efficiency than either the photovoltaic array or the heat engine alone can attain. Advantages in concentrator and radiator area and receiver mass of the photovoltaic heat engine system over a heat-engine-only system are estimated. A mass and area comparison between the proposed space station organic Rankine power system and a combination PV-heat engine system is made. The critical problem for the proposed converter is the necessity for high temperature photovoltaic array operation. Estimates of the required photovoltaic temperature are presented.

  19. Combining Ideas in Crowdsourced Idea Generation

    Directory of Open Access Journals (Sweden)

    Wang Kai

    2017-02-01

    Full Text Available Collecting ideas through crowdsourcing has become a common practice for companies to benefit from external ideas and innovate. It is desirable that crowd members build on each other's ideas to achieve synergy. This study proposes and verifies a new method for idea combination which can result in combined ideas that are both novel and useful. The domain-specific knowledge of crowd members does not influence the effectiveness of such idea combination. The new method can be used for collecting highly creative ideas from the crowd. The implications for future research are discussed.

  20. Combining or Separating Forward and Reverse Logistics

    DEFF Research Database (Denmark)

    Herbert-Hansen, Zaza Nadja Lee; Larsen, Samuel; Nielsen, Anders

    2018-01-01

    % combination to 100% combination (i.e. full separation). Second, using contingency theory the paper identifies the contextual factors described in RL-literature that determine the most advantageous degree of combination. The set of factors is subsequently tested using a case study, which applies......-research addresses intra-RL issues while the relationship between forward and reverse logistics is under-researched. This paper contributes to RL-theory by identifying the contextual factors that determine the most advantageous relationship between forward and reverse logistics, and proposes a novel decision making...

  1. All-fiber 7x1 signal combiner for incoherent laser beam combining

    DEFF Research Database (Denmark)

    Noordegraaf, Danny; Maack, Martin D.; Skovgaard, Peter M. W.

    2011-01-01

    We demonstrate an all-fiber 7x1 signal combiner for incoherent laser beam combining. This is a potential key component for reaching several kW of stabile laser output power. The combiner couples the output from 7 single-mode (SM) fiber lasers into a single multi-mode (MM) fiber. The input signal ...

  2. Current update on combined hepatocellular-cholangiocarcinoma

    Directory of Open Access Journals (Sweden)

    Suresh Maximin

    2014-01-01

    Combined hepatocellular cholangiocarcinoma tends to present with an more aggressive behavior and a poorer prognosis than either hepatocellular carcinoma or cholangiocarcinoma. An accurate preoperative diagnosis and aggressive treatment planning can play crucial roles in appropriate patient management.

  3. Ameliorative Effects of Herbal Combinations in Hyperlipidemia

    Directory of Open Access Journals (Sweden)

    Nishant P. Visavadiya

    2011-01-01

    Full Text Available The roots of Glycyrrhiza glabra, Withania somnifera, Asparagus racemosus, and Chlorophytum borivilianum and seeds of Sesamum indicum are ayurvedic medicinal plants used in India to treat several ailments. Our previous studies indicated that these plants possess hypolipidemic and antioxidant potential. The present study was aimed at investigating the composite effects of these plants on hypercholesterolemic rats. Three different combinations (5 gm%, given for four weeks used in this study effectively reduced plasma and hepatic lipid profiles and increased fecal excretion of cholesterol, neutral sterol, and bile acid along with increasing the hepatic HMG-CoA reductase activity and bile acid content in hypercholesterolemic rats. Further, all three combinations also improved the hepatic antioxidant status (catalase, SOD, and ascorbic acid levels and plasma total antioxidant capacity with reduced hepatic lipid peroxidation. Overall, combination I had the maximum effect on hypercholesterolemic rats followed by combinations II and III due to varying concentrations of the different classes of phytocomponents.

  4. Combining multiple classifiers for age classification

    CSIR Research Space (South Africa)

    Van Heerden, C

    2009-11-01

    Full Text Available classifier is also developed by using an SVM to predict posterior class probabilities using two different types of classifier outputs; gender classification results and regression age estimates. The authors show that for combining posterior probabilities...

  5. Combination Classes and "Hora de comunicacion."

    Science.gov (United States)

    Eldredge, Dee L.

    1989-01-01

    Ways to combine small classes of higher education students studying Spanish at various levels are described, including judicious use of language laboratories, staggering of the different level groups, and rotation of activities geared toward students' individual proficiency levels. (CB)

  6. Unrewarded Object Combinations in Captive Parrots

    Directory of Open Access Journals (Sweden)

    Alice Marie Isabel Auersperg

    2014-11-01

    Full Text Available In primates, complex object combinations during play are often regarded as precursors of functional behavior. Here we investigate combinatory behaviors during unrewarded object manipulation in seven parrot species, including kea, African grey parrots and Goffin cockatoos, three species previously used as model species for technical problem solving. We further examine a habitually tool using species, the black palm cockatoo. Moreover, we incorporate three neotropical species, the yellow- and the black-billed Amazon and the burrowing parakeet. Paralleling previous studies on primates and corvids, free object-object combinations and complex object-substrate combinations such as inserting objects into tubes/holes or stacking rings onto poles prevailed in the species previously linked to advanced physical cognition and tool use. In addition, free object-object combinations were intrinsically structured in Goffin cockatoos and in kea.

  7. PANSAID - PAracetamol and NSAID in combination

    DEFF Research Database (Denmark)

    Thybo, Kasper Højgaard; Hägi-Pedersen, Daniel; Wetterslev, Jørn

    2017-01-01

    BACKGROUND: Effective postoperative pain management is essential for the rehabilitation of the surgical patient. No 'gold standard' exists after total hip arthroplasty (THA) and combinations of different nonopioid medications are used with virtually no evidence for additional analgesic efficacy c...

  8. Combined assessment (aspiration cytology and mammography) of ...

    African Journals Online (AJOL)

    Combined assessment (aspiration cytology and mammography) of clinically suspicious breast masses. W.F. van Wyk, D Dent, E Anne Hacking, Genevieve Learmonth, R.E. Kottler, C Anne Gudgeon, A Tiltman ...

  9. Predictors of combined cognitive and physical decline

    NARCIS (Netherlands)

    Atkinson, H.H.; Cesari, M.; Kritchevsky, S.B.; Penninx, B.W.J.H.; Fried, L.P.; Guralnik, J.M.; Williamson, J.D.

    2005-01-01

    OBJECTIVES: To determine the incidence and correlates of combined declines in cognitive and physical performance. DESIGN: Cohort study of community-dwelling older women with moderate to severe disability. SETTING: The community surrounding Baltimore, Maryland. PARTICIPANTS: Participants in the

  10. Power combining considerations for Prometheus TWTAs

    Science.gov (United States)

    Komm, David S.; Smith, S. K.; Menninger, W. L.

    2005-01-01

    This slide presentation reviws the planning for a nuclear-electric spacecraft. It includes information concerning one considered mission, communications requirements, power combining, four-beam cluster antenna, and amplitude and phase variations.

  11. Ameliorative effects of herbal combinations in hyperlipidemia.

    Science.gov (United States)

    Visavadiya, Nishant P; Narasimhacharya, A V R L

    2011-01-01

    The roots of Glycyrrhiza glabra, Withania somnifera, Asparagus racemosus, and Chlorophytum borivilianum and seeds of Sesamum indicum are ayurvedic medicinal plants used in India to treat several ailments. Our previous studies indicated that these plants possess hypolipidemic and antioxidant potential. The present study was aimed at investigating the composite effects of these plants on hypercholesterolemic rats. Three different combinations (5 gm%, given for four weeks) used in this study effectively reduced plasma and hepatic lipid profiles and increased fecal excretion of cholesterol, neutral sterol, and bile acid along with increasing the hepatic HMG-CoA reductase activity and bile acid content in hypercholesterolemic rats. Further, all three combinations also improved the hepatic antioxidant status (catalase, SOD, and ascorbic acid levels) and plasma total antioxidant capacity with reduced hepatic lipid peroxidation. Overall, combination I had the maximum effect on hypercholesterolemic rats followed by combinations II and III due to varying concentrations of the different classes of phytocomponents.

  12. Novel Combination Chemotherapy for Localized Ewing Sarcoma

    Science.gov (United States)

    In this clinical trial, researchers will test whether the addition of the drug combination vincristine, topotecan, and cyclophosphamide to a standard chemotherapy regimen improves overall survival in patients with extracranial Ewing

  13. Coherent combining pulse bursts in time domain

    Science.gov (United States)

    Galvanauskas, Almantas

    2018-01-09

    A beam combining and pulse stacking technique is provided that enhances laser pulse energy by coherent stacking pulse bursts (i.e. non-periodic pulsed signals) in time domain. This energy enhancement is achieved by using various configurations of Fabry-Perot, Gires-Tournois and other types of resonant cavities, so that a multiple-pulse burst incident at either a single input or multiple inputs of the system produces an output with a solitary pulse, which contains the summed energy of the incident multiple pulses from all beams. This disclosure provides a substantial improvement over conventional coherent-combining methods in that it achieves very high pulse energies using a relatively small number of combined laser systems, thus providing with orders of magnitude reduction in system size, complexity, and cost compared to current combining approaches.

  14. Beam Combination for Sparse Aperture Telescopes Project

    Data.gov (United States)

    National Aeronautics and Space Administration — This proposal is for funding to continue development of an alternative beam combiner for Stellar Imager (SI), a 30-aperture, interferometric telescope chosen as one...

  15. Advances in combination therapy of lung cancer

    DEFF Research Database (Denmark)

    Wu, Lan; Leng, Donglei; Cun, Dongmei

    2017-01-01

    Lung cancer is a complex disease caused by a multitude of genetic and environmental factors. The progression of lung cancer involves dynamic changes in the genome and a complex network of interactions between cancer cells with multiple, distinct cell types that form tumors. Combination therapy......, including small molecule drugs and biopharmaceuticals, which make the optimization of dosing and administration schedule challenging. This article reviews the recent advances in the design and development of combinations of pharmaceuticals for the treatment of lung cancer. Focus is primarily on rationales...... for the selection of specific combination therapies for lung cancer treatment, and state of the art of delivery technologies and dosage regimens for the combinations, tested in preclinical and clinical trials....

  16. Optimizing sales areas of combined transport chains

    Directory of Open Access Journals (Sweden)

    Philip Michalk

    2013-12-01

    Full Text Available Background: Combined transport chains (such as intermodal transport, have certain advantages. The main advantage from customer points of view is the possibility to bundle freight and thereby decrease transport costs. On the other hand, a combined transport chain can cause longer transport times, due to the necessary transshipment processes. Methods: The area around a terminal, in which a combined service has favourable properties to a customer in comparison to a direct transport, can be understood as a sales-area, in which a combined transport product is marketable. The aim of this paper was to find a method to determine the best shape and size of this area. Results and conclusions: The paper at hand lined out a method in order to calculate such a sales area and determine which geographical points around a terminal have an advantage in comparison to a direct transport service.

  17. Combination Antifungal Therapy for Cryptococcal Meningitis

    OpenAIRE

    Day, Jeremy N.; Chau, Tran T.H.; Wolbers, Marcel; Mai, Pham P.; Dung, Nguyen T.; Mai, Nguyen H.; Phu, Nguyen H.; Nghia, Ho D.; Phong, Nguyen D.; Thai, Cao Q.; Thai, Le H.; Chuong, Ly V.; Sinh, Dinh X.; Duong, Van A.; Hoang, Thu N.

    2013-01-01

    Background\\ud Combination antifungal therapy (amphotericin B deoxycholate and flucytosine) is the recommended treatment for cryptococcal meningitis but has not been shown to reduce mortality, as compared with amphotericin B alone. We performed a randomized, controlled trial to determine whether combining flucytosine or high-dose fluconazole with high-dose amphotericin B improved survival at 14 and 70 days.\\ud Methods\\ud We conducted a randomized, three-group, open-label trial of induction the...

  18. Automatic Synthesis of Multilevel Combinational Logic

    DEFF Research Database (Denmark)

    Andersen, Anders C.; Madsen, Jan; Madsen, J.R.

    1989-01-01

    This paper describes a system for the synthesis of multilevel combinational logic, transforming functional description into mask layout. The system includes a logic synthesis part, partly consisting of tools developed at Eindhoven University of Technology, which has been interfaced to the layout ...... synthesis part in the CATOE-system, developed at the DesignCenter of Electronics Institute. The various steps in the transformation are presented together with a complete design example, implementing a multi-output combinational decoder function....

  19. Proximal Row Carpectomy Combined with Wrist Hemiarthroplasty

    OpenAIRE

    Culp, Randall W.; Bachoura, Abdo; Gelman, Scott E.; Jacoby, Sidney M.

    2012-01-01

    Proximal row carpectomy (PRC) combined with distal radius hemiarthroplasty is a relatively novel procedure that rivals total wrist arthrodesis and offers a new surgical treatment option for select patients with painful, end-stage wrist disease. We present our early experience with this procedure. A retrospective chart review was conducted for nonrheumatoid patients diagnosed with wrist arthritis and subsequently treated with wrist hemiarthroplasty combined with PRC. The minimum follow-up dura...

  20. Combined surface and volumetric occlusion shading

    KAUST Repository

    Schott, Matthias O.

    2012-02-01

    In this paper, a method for interactive direct volume rendering is proposed that computes ambient occlusion effects for visualizations that combine both volumetric and geometric primitives, specifically tube shaped geometric objects representing streamlines, magnetic field lines or DTI fiber tracts. The proposed algorithm extends the recently proposed Directional Occlusion Shading model to allow the rendering of those geometric shapes in combination with a context providing 3D volume, considering mutual occlusion between structures represented by a volume or geometry. © 2012 IEEE.

  1. RF waveguide phase-directed power combiners

    Energy Technology Data Exchange (ETDEWEB)

    Nantista, Christopher D.; Dolgashev, Valery A.; Tantawi, Sami G.

    2017-05-02

    High power RF phase-directed power combiners include magic H hybrid and/or superhybrid circuits oriented in orthogonal H-planes and connected using E-plane bends and/or twists to produce compact 3D waveguide circuits, including 8.times.8 and 16.times.16 combiners. Using phase control at the input ports, RF power can be directed to a single output port, enabling fast switching between output ports for applications such as multi-angle radiation therapy.

  2. NFL Combine Athletic Performance after ACL Reconstruction

    OpenAIRE

    Marshall, Nathan E.; Keller, Robert A.; Mehran, Nima; Austin, William; Moutzouros, Vasilios

    2016-01-01

    Objectives: The purpose of this study was to determine the functional performance of NFL combine participants after ACL reconstruction compared with an age-, size-, and position-matched control group. The hypothesis was that there would be no difference between players after ACL reconstruction as compared with controls in functional athletic performance. Methods: A total of 98 NFL-caliber athletes who had undergone primary ACL reconstruction and participated in the NFL scouting combine betwee...

  3. Combining Stocks and Flows of Knowledge

    DEFF Research Database (Denmark)

    Ambos, Tina C.; Nell, Phillip Christopher; Pedersen, Torben

    2013-01-01

    While previous research has mostly focused on either knowledge stocks or knowledge flows, our study is among the first to integrate these perspectives in order to shed light on the complementarity effects of different types of knowledge stocks and flows in the multinational corporation (MNC...... of complementarity create benefits for these units, but that the effects from intra-functional combinations of knowledge stocks and flows are significantly stronger than from cross-functional combinations....

  4. Combination therapy in hypertension: An update

    Directory of Open Access Journals (Sweden)

    Kalra Sanjay

    2010-06-01

    Full Text Available Abstract Meticulous control of blood pressure is required in patients with hypertension to produce the maximum reduction in clinical cardiovascular end points, especially in patients with comorbidities like diabetes mellitus where more aggressive blood pressure lowering might be beneficial. Recent clinical trials suggest that the approach of using monotherapy for the control of hypertension is not likely to be successful in most patients. Combination therapy may be theoretically favored by the fact that multiple factors contribute to hypertension, and achieving control of blood pressure with single agent acting through one particular mechanism may not be possible. Regimens can either be fixed dose combinations or drugs added sequentially one after other. Combining the drugs makes them available in a convenient dosing format, lower the dose of individual component, thus, reducing the side effects and improving compliance. Classes of antihypertensive agents which have been commonly used are angiotensin receptor blockers, thiazide diuretics, beta and alpha blockers, calcium antagonists and angiotensin-converting enzyme inhibitors. Thiazide diuretics and calcium channel blockers are effective, as well as combinations that include renin-angiotensin-aldosterone system blockers, in reducing BP. The majority of currently available fixed-dose combinations are diuretic-based. Combinations may be individualized according to the presence of comorbidities like diabetes mellitus, chronic renal failure, heart failure, thyroid disorders and for special population groups like elderly and pregnant females.

  5. Demography, vulnerabilities and right to health to Brazilian prison population.

    Science.gov (United States)

    Soares, Marden Marques; Bueno, Paula Michele Martins Gomes

    2016-06-01

    This study investigates the latest research on the profile of the Brazilian prison population, its demography and current laws and regulations. It aims in the direction of ensuring the human right to health. Brazilian prison system is a complex universe in which state and federal criminal contexts keep more than 607,000 people in custody. This population is composed of 75% of young and black people, 67% poorly educated and 41% are pre-trial detainees, living in overcrowded prisons and architecturally vandalized, with population growth of around 575% in 24 years, making this environment a major focus of production of diseases. The prison becomes the object of differentiated intervention by public bodies linked to the executive and the judiciary - it is worth remarking that the data show the high level of inequalities and health vulnerabilities among the prison population, whose needs involve a set of cross-sector of transverse public policies actions towards penal execution.

  6. Exact analysis of Packet Reversed Packet Combining Scheme and Modified Packet Combining Scheme; and a combined scheme

    International Nuclear Information System (INIS)

    Bhunia, C.T.

    2007-07-01

    Packet combining scheme is a well defined simple error correction scheme for the detection and correction of errors at the receiver. Although it permits a higher throughput when compared to other basic ARQ protocols, packet combining (PC) scheme fails to correct errors when errors occur in the same bit locations of copies. In a previous work, a scheme known as Packet Reversed Packet Combining (PRPC) Scheme that will correct errors which occur at the same bit location of erroneous copies, was studied however PRPC does not handle a situation where a packet has more than 1 error bit. The Modified Packet Combining (MPC) Scheme that can correct double or higher bit errors was studied elsewhere. Both PRPC and MPC schemes are believed to offer higher throughput in previous studies, however neither adequate investigation nor exact analysis was done to substantiate this claim of higher throughput. In this work, an exact analysis of both PRPC and MPC is carried out and the results reported. A combined protocol (PRPC and MPC) is proposed and the analysis shows that it is capable of offering even higher throughput and better error correction capability at high bit error rate (BER) and larger packet size. (author)

  7. The danger of fixed drug combinations.

    Science.gov (United States)

    Herxheimer, H

    1975-07-01

    After the second world war a number of pharmaceutical firms which were not able to create new therapeutic substances by their own research, put a great number of fixed drug combinations on the market. Their number quickly increased, as the efficiency of these compounds required no legal proof and as, with appropriate propaganda, large profits could be earned. The number of firms doing this sort of production also increased, and in West Germany, for instance, more than 3/4 of all drugs on the official list are now fixed combinations. Our task is, therefore, to ask for regulations which limit fixed combinations to such preparation the efficiency of which has been shown and whose advantages more than outweigh their disadvantages. The advantages of these preparations are convenience to the patient, avoidance of potential mistakes made possible by too many drugs given on the same day and, perhaps, lower prices. The disadvantages are: 1. The individual optimum dose for a patient cannot be achieved, because in case of a change of dosis all components are changed. 2. Different components may have different duration of action. 3. Different components may have a different bioavailability. 4. Different components may interact. 5. Some components may create tolerance, others not. In many cases fixed combinations have been used to make drugs with poor efficiency financially viable by combining them with very efficient drugs. The existence of thousands of fixed combinations makes the drug market indiscernible and useless. They obscure the relatively few essential drugs and make it difficult for the doctor to find his way amongst the mass of offered medicaments. Few fixed combinations are justifiable. These are well known and they should be permitted as before. All others should be banned until it has been shown that their advantages are greater than their disadvantages.

  8. Combined radiochemotherapy of head and neck cancer

    International Nuclear Information System (INIS)

    Schlappack, O.; Springer, B.; Hainz, A.

    1994-01-01

    Advanced tumors of the head and neck are often treated with combined radiochemotherapy. The chemotherapeutic agents used should be active in this tumor type and its adverse effects should not overlap with those of the radiation treatment. Published studies were reviewed and discussed on the basis of these principles. Initially, single agents such as 5-fluorouracil (5-FU) and methotrexate were used in combination with radiotherapy. These combinations caused an improved local tumor control but also an increased mucosal reaction. For mitomycin C it has been shown in a randomized trial that local tumor control was improved without concomitant increased normal tissue toxicity. Also cisplatin and carboplatin were studied in combination with radiotherapy. Unfortunately, there are no results of randomized studies available but these agents do not seem to increase mucosal toxicity. The standard chemotherapy of squamous cell carcinomas of the head and neck is cisplatin and 5-FU. Many studies have been conducted with this chemotherapy in combination with radiotherapy. To this day it has not been shown that the results of an effective radiation treatment or an effective chemotherapy can be improved by these experiments. The explanation for that is that either the chemotherapy or the radiotherapy cannot be given at full dose because the regimen would become too toxic. 5-FU containing polychemotherapy regimens should not be combined with radiation any more because it is known that 5-FU increases the mucosal reaction. Agents that could be studied in the future either alone or in combination with cisplatin or carboplatin are etoposide and taxol. (orig.) [de

  9. Combined precut in difficult biliary cannulation

    Directory of Open Access Journals (Sweden)

    Jesús Espinel-Díez

    2013-06-01

    Full Text Available Aim: precut sphincterotomy refers to a variety of endoscopic techniques that are used in order to access the bile duct when conventional methods of cannulation have failed. There are not significant data (such as efficacy, safety about the use of different techniques of precutting at the same session. We have described our experience with combined precut sphincterotomy (CPS and we have compared our results to the use of an isolated precut. Patients and methods: we have performed 247 precuts of a total of 2.390 ERCPs. Patients were distributed according to the type of precut practiced: Needle-knife, transpancreatic and combined precut sphincterotomies. "Combined precut" consisted in performing first a transpancreatic sphincterotomy and, if the access was not achieved, then performing a needle-knife sphincterotomy in the same session. The data about safety and efficacy were prospectively collected. The complications were defined according to the consensus criteria. Results: we performed precutting techniques in 247 patients. Needle-knife, transpancreatic, and combined precuts were performed in 125 (6.9%, 74 (4.1% and 48 (2.6% patients, respectively. Bile duct cannulation was successful in 48 patients (100% in the group of combined precut, 121 patients (96.8% in the transpancreatic group, and 67 patients (90.5% in the needle-knife group (p = 0.03. There were not differences in complications rates between the three groups. There was no pancreatitis in the combined precut group. The complications were successfully managed with conservative treatment. Conclusions: combined precut sphincterotomy seems to be a safe and successful technique in those cases of difficult bile duct cannulation.

  10. A cost-minimization analysis of combination therapy in hypertension: fixed-dose vs extemporary combinations

    Directory of Open Access Journals (Sweden)

    Marco Bellone

    2013-12-01

    Full Text Available BACKGROUND: Cardiovascular disease management and prevention represent the leading cost driver in Italian healthcare expenditure. In order to reach the target blood pressure, a large majority of patients require simultaneous administration of multiple antihypertensive agents.OBJECTIVE: To assess the economic impact of the use of fixed dose combinations of antihypertensive agents, compared to the extemporary combination of the same principles.METHODS: A cost minimization analysis was conducted to determine the pharmaceutical daily cost of five fixed dose combinations (olmesartan 20 mg + amlodipine 5 mg, perindopril 5 mg + amlodipine 5 mg, enalapril 20 mg + lercanidipine 10 mg, felodipine 5 mg + ramipril 5 mg, and delapril 30 mg + manidipine 10 mg compared with extemporary combination of the same principles in the perspective of the Italian NHS. Daily acquisition costs are estimated based on current Italian prices and tariffs.RESULTS: In three cases the use of fixed‑dose combination instead of extemporary combination induces a lower daily cost. Fixed combination treatment with delapril 30 mg + manidipine 10 mg induces greater cost savings for the National Health System (95,47 €/pts/year, as compared to free drugs combination therapy.CONCLUSIONS: Compared with free drug combinations, fixed‑dose combinations of antihypertensive agents are associated with lower daily National Health Service acquisition costs.http://dx.doi.org/10.7175/fe.v14i4.886

  11. Energy Analysis in Combined Reforming of Propane

    Directory of Open Access Journals (Sweden)

    K. Moon

    2013-01-01

    Full Text Available Combined (steam and CO2 reforming is one of the methods to produce syngas for different applications. An energy requirement analysis of steam reforming to dry reforming with intermediate steps of steam reduction and equivalent CO2 addition to the feed fuel for syngas generation has been done to identify condition for optimum process operation. Thermodynamic equilibrium data for combined reforming was generated for temperature range of 400–1000°C at 1 bar pressure and combined oxidant (CO2 + H2O stream to propane (fuel ratio of 3, 6, and 9 by employing the Gibbs free energy minimization algorithm of HSC Chemistry software 5.1. Total energy requirement including preheating and reaction enthalpy calculations were done using the equilibrium product composition. Carbon and methane formation was significantly reduced in combined reforming than pure dry reforming, while the energy requirements were lower than pure steam reforming. Temperatures of minimum energy requirement were found in the data analysis of combined reforming which were optimum for the process.

  12. Inappropriate combination of warfarin and aspirin.

    Science.gov (United States)

    Turan, Burak; Demir, Hakan; Mutlu, Ayhan; Daşlı, Tolga; Erkol, Ayhan; Erden, İsmail

    2016-03-01

    A combination of warfarin and aspirin is associated with increased bleeding compared with warfarin monotherapy. The aim of the study was to investigate the incidence and appropriateness of the combination of warfarin and aspirin in patients with atrial fibrillation (AF) or mechanical heart valve (MHV). This cross-sectional study included consecutive patients with AF or MHV on chronic warfarin therapy (>3 months) without acute coronary syndrome or have not undergone a revascularization procedure in the preceding year. Medical history, concomitant diseases, and treatment data were acquired through patient interviews and from hospital records. Three hundred and sixty patients (213 with AF, 147 with MHV) were included. In those with AF, a significantly higher warfarin-aspirin combination was observed with concomitant vascular disease (38.8% vs. 14.6%), diabetes (36.6% vs. 16.3%), statin therapy (40% vs. 16.9%), left ventricular systolic dysfunction (33.3% vs. 17.5%) (paspirin combination were concomitant vascular disease, diabetes, and (younger) age in patients with AF and were concomitant AF and male sex in patients with MHV. Interestingly, the incidence of combination therapy was found to increase with a higher HAS-BLED score in both patients with AF and MHV (paspirin was found to be prescribed to patients with AF mainly for the prevention of cardiovascular events, for which warfarin monotherapy usually suffices. On the other hand, co-treatment with aspirin appeared to be underused in patients with MHV.

  13. Improving exposure estimates by combining exposure information.

    Science.gov (United States)

    Neitzel, Richard L; Daniell, William E; Sheppard, Lianne; Davies, Hugh W; Seixas, Noah S

    2011-06-01

    Any exposure estimation technique has inherent strengths and limitations. In an effort to improve exposure estimates, this study developed and evaluated the performance of several hybrid exposure estimates created by combining information from individual assessment techniques. Construction workers (n = 68) each completed three full-shift noise measurements over 4 months. Three single exposure assessment techniques [trade mean (TM), task-based (TB), and subjective rating (SR)] were used to estimate exposures for each subject. Hybrid techniques were then developed which incorporated the TM, SR, and TB noise exposure estimates via arithmetic mean combination, linear regression combination, and modification of TM and TB estimates using SR information. Exposure estimates from the single and hybrid techniques were compared to subjects' measured exposures to evaluate accuracy. Hybrid estimates generally were more accurate than estimates from single techniques. The best-performing hybrid techniques combined TB and SR estimates and resulted in improvements in estimated exposures compared to single techniques. Hybrid estimates were not improved by the inclusion of TM information in this study. Hybrid noise exposure estimates performed better than individual estimates, and in this study, combination of TB and SR estimates using linear regression performed best. The application of hybrid approaches in other contexts will depend upon the exposure of interest and the nature of the individual exposure estimates available.

  14. Exercise, fasting, and mimetics: toward beneficial combinations?

    Science.gov (United States)

    Jaspers, Richard T; Zillikens, M Carola; Friesema, Edith C H; delli Paoli, Giuseppe; Bloch, Wilhelm; Uitterlinden, André G; Goglia, Fernando; Lanni, Antonia; de Lange, Pieter

    2017-01-01

    Obesity and type 2 diabetes are associated disorders that involve a multiplicity of tissues. Both fasting and physical exercise are known to counteract dyslipidemia/hyperglycemia. Skeletal muscle plays a key role in the control of blood glucose levels, and the metabolic changes and related signaling pathways in skeletal muscle induced by fasting overlap with those induced by exercise. The reduction of fat disposal has been shown to extend to the liver and to white and brown adipose tissue and to involve an increase in their metabolic activities. In recent years signal transduction pathways related to exercise and fasting/food withdrawal in muscle have been intensively studied, both in animals and in humans. Combining fasting/food withdrawal with exercise in animals as well as in humans causes changes unlike those seen during fasting/food withdrawal or exercise alone, which favor repair of muscle over autophagy. In addition, compounds that mimic exercise have been studied in combination with exercise or fasting/food withdrawal. This review addresses our current knowledge of the mechanisms that underlie the individual and combined effects of fasting/food withdrawal, endurance or resistance exercise, and their mimetics, in muscle vs other organs in rodents and humans, and highlights which combinations may improve metabolic disorders.-Jaspers, R. T., Zillikens, M. C., Friesema, E. C. H., delli Paoli, G., Bloch, W., Uitterlinden, A. G., Goglia, F., Lanni, A., de Lange, P. Exercise, fasting, and mimetics: toward beneficial combinations. © FASEB.

  15. Combined microstructure x-ray optics

    International Nuclear Information System (INIS)

    Barbee, T.W. Jr.

    1989-02-01

    Multilayers are man-made microstructures which vary in depth and are now of sufficient quality to be used as x-ray, soft x-ray and extreme ultraviolet optics. Gratings are man-made in plane microstructures which have been used as optic elements for most of this century. Joining of these two optical microstructures to form combined microstructure optical microstructures to form combined microstructure optical elements has the potential for greatly enhancing both the throughput and the resolution attainable in these spectral ranges. The characteristics of these new optic elements will be presented and compared to experiment with emphasis on the unique properties of these combined microstructures. These results reported are general in nature and not limited to the soft x-ray or extreme ultraviolet spectral domains and also apply to neutrons. 19 refs., 7 figs., 4 tabs

  16. Combined bending-torsion fatigue reliability. III

    Science.gov (United States)

    Kececioglu, D.; Chester, L. B.; Nolf, C. F., Jr.

    1975-01-01

    Results generated by three, unique fatigue reliability research machines which can apply reversed bending loads combined with steady torque are presented. AISI 4340 steel, grooved specimens with a stress concentration factor of 1.42 and 2.34, and Rockwell C hardness of 35/40 were subjected to various combinations of these loads and cycled to failure. The generated cycles-to-failure and stress-to-failure data are statistically analyzed to develop distributional S-N and Goodman diagrams. Various failure theories are investigated to determine which one represents the data best. The effects of the groove, and of the various combined bending-torsion loads, on the S-N and Goodman diagrams are determined. Two design applications are presented which illustrate the direct useability and value of the distributional failure governing strength and cycles-to-failure data in designing for specified levels of reliability and in predicting the reliability of given designs.

  17. OT-Combiners Via Secure Computation

    DEFF Research Database (Denmark)

    Harnik, Danny; Ishai, Yuval; Kushilevitz, Eyal

    2008-01-01

    , in a network consisting of a single OT-channel. Our approach applies both to the “semi-honest” and the “malicious” models of secure computation, yielding the corresponding types of OT-combiners. Instantiating our general approach with secure computation protocols from the literature, we conceptually simplify....... These include: Constant-rate OTs from a noisy channel. We implement n instances of a standard -OT by communicating just O(n) bits over a noisy channel (binary symmetric channel). Our reduction provides unconditional security in the semi-honest model. Previous reductions of this type required the use of Ω......An OT-combiner implements a secure oblivious transfer (OT) protocol using oracle access to n OT-candidates of which at most t may be faulty. We introduce a new general approach for combining OTs by making a simple and modular use of protocols for secure computation. Specifically, we obtain an OT...

  18. [Combined-modality therapy for lung cancer].

    Science.gov (United States)

    Miura, Satoru; Yamamoto, Nobuyuki

    2010-06-01

    Lung cancer is treated with surgery, radiotherapy and chemotherapy according to histology and clinical stage. Advanced stage lung cancer patients cannot be cured, but early and locally-advanced stage patients can be cured by intensive combined-modality therapy. Combined-modality therapy with surgery plus adjuvant chemotherapy is standard for resectable IB-IIIA non-small cell lung cancer (NSCLC) and stage I small cell lung cancer (SCLC) patients. Chemoradiotherapy is standard for unresectable locally-advanced NSCLC and limited-stage SCLC patients. Recently, several new drugs, molecular targeted drugs, have become available for clinical use and trials. We reviewed standard and new strategy of combined-modality therapy for early and locally-advanced lung cancer patients.

  19. Coherent combination of ultrafast fiber amplifiers

    International Nuclear Information System (INIS)

    Hanna, Marc; Guichard, Florent; Druon, Frédéric; Georges, Patrick; Zaouter, Yoann; Papadopoulos, Dimitris N

    2016-01-01

    We review recent progress in coherent combining of femtosecond pulses amplified in optical fibers as a way to scale the peak and average power of ultrafast sources. Different methods of achieving coherent pulse addition in space (beam combining) and time (divided pulse amplification) domains are described. These architectures can be widely classified into active methods, where the relative phases between pulses are subject to a servomechanism, and passive methods, where phase matching is inherent to the geometry. Other experiments that combine pulses with different spectral contents, pulses that have been nonlinearly broadened or successive pulses from a mode-locked laser oscillator, are then presented. All these techniques allow access to unprecedented parameter range for fiber ultrafast sources. (topical review)

  20. Artificial intelligence in drug combination therapy.

    Science.gov (United States)

    Tsigelny, Igor F

    2018-02-09

    Currently, the development of medicines for complex diseases requires the development of combination drug therapies. It is necessary because in many cases, one drug cannot target all necessary points of intervention. For example, in cancer therapy, a physician often meets a patient having a genomic profile including more than five molecular aberrations. Drug combination therapy has been an area of interest for a while, for example the classical work of Loewe devoted to the synergism of drugs was published in 1928-and it is still used in calculations for optimal drug combinations. More recently, over the past several years, there has been an explosion in the available information related to the properties of drugs and the biomedical parameters of patients. For the drugs, hundreds of 2D and 3D molecular descriptors for medicines are now available, while for patients, large data sets related to genetic/proteomic and metabolomics profiles of the patients are now available, as well as the more traditional data relating to the histology, history of treatments, pretreatment state of the organism, etc. Moreover, during disease progression, the genetic profile can change. Thus, the ability to optimize drug combinations for each patient is rapidly moving beyond the comprehension and capabilities of an individual physician. This is the reason, that biomedical informatics methods have been developed and one of the more promising directions in this field is the application of artificial intelligence (AI). In this review, we discuss several AI methods that have been successfully implemented in several instances of combination drug therapy from HIV, hypertension, infectious diseases to cancer. The data clearly show that the combination of rule-based expert systems with machine learning algorithms may be promising direction in this field. © The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  1. Efficient power combiner for THz radiation

    Directory of Open Access Journals (Sweden)

    Hamide Seidfaraji

    2016-08-01

    Full Text Available Most dangerous explosive materials, both toxic and radioactive, contain nitrogen salts with resonant absorption lines in the frequency range 0.3-10 THz. Therefore, there has been growing interest in remotely detecting such materials by observing the spectrum of reflected signals when the suspicious material is interrogated by THz radiation. Practical portable THz sources available today generate only 20–40 mW output power. This power level is too low to interrogate suspicious material from a safe distance, especially if the material is concealed. Hence, there is a need for sources that can provide greater power in the THz spectrum. Generating and extracting high output power from THz sources is complicated and inefficient. The efficiency of vacuum electronic microwave sources is very low when scaled to the THz range and THz sources based on scaling down semiconductor laser sources have low efficiency as well, resulting in the well known “THz gap.” The reason for such low efficiencies for both source types is material losses in the THz band. In this article an efficient power combiner is described that is based on scaling to higher frequencies a microwave combiner that increases the output power in the THz range of interest in simulation studies. The proposed power combiner not only combines the THz power output from several sources, but can also form a Gaussian wavebeam output. A minimum conversion efficiency of 89% with cophased inputs in a lossy copper power combiner and maximum efficiency of 100% in a Perfect Electric Conductor (PEC-made power combiner were achieved in simulations. Also, it is shown that the TE01 output mode is a reasonable option for THz applications due to the fact that conductive loss decreases for this mode as frequency increases.

  2. Combined treatment for complex intracranial aneurysm

    Directory of Open Access Journals (Sweden)

    Chiriac A.

    2015-06-01

    Full Text Available Complex aneurysms often cannot be completely excluded by a single approaches. Today successful treatment of these lesions requires a combination between microsurgical and endovascular techniques. Planning of combined treatment require a very good understanding of aneurysm anatomy and a close collaboration between neurosurgeon and neuroendovascular interventionist. Endovascular coiling can usually be used as early treatment for a partially aneurysm occlusion including the ruptured area and followed by definitive clipping. On the other hand microsurgical clipping also can be used as first treatment for complex aneurysm neck reconstruction, allowing successful secondary placement of coils inside the remnant aneurysm sac

  3. Combined utilization of biogas and natural gas

    International Nuclear Information System (INIS)

    Jensen, J.; Tafdrup, S.; Christensen, J.

    1997-01-01

    The Danish natural gas network has been established during the past 10 years. Running parallel with this a small but growing production of biogas from centralized biogas plants and landfills has been developed. The annual biogas production is expected to keep growing and increase tenfold in the next 25 year period with a reduction of green house gas emissions as one of the important incentives. The last years' development and expansion of the Danish biogas sector has shown a need for combined utilization of biogas and natural gas. If larger volumes of biogas are present, upgrading and distribution by the natural gas network may be an alternative to combined utilization. (au) 12 refs

  4. Wind turbine blade testing under combined loading

    DEFF Research Database (Denmark)

    Roczek-Sieradzan, Agnieszka; Nielsen, Magda; Branner, Kim

    2011-01-01

    The paper presents full-scale blade tests under a combined flap- and edgewise loading. The main aim of this paper is to present the results from testing a wind turbine blade under such conditions and to study the structural behavior of the blade subjected to combined loading. A loading method using...... anchor plates was applied, allowing transverse shear distortion. The global and local deformation of the blade as well as the reproducibility of the test was studied and the results from the investigations are presented....

  5. Maximisation of Combined Cycle Power Plant Efficiency

    Directory of Open Access Journals (Sweden)

    Janusz Kotowicz

    2015-12-01

    Full Text Available The paper presents concepts for increasing the efficiency of a modern combined cycle power plant. Improvement of gas turbine performance indicators as well as recovering heat from the air cooling the gas turbine’s flow system enable reaching gross electrical efficiencies of around 65%. Analyses for a wide range of compressor pressure ratios were performed. Operating characteristics were developed for the analysed combined cycle plant, for different types of open air cooling arrangements of the gas turbine’s expander: convective, transpiration and film.

  6. Combined air and water pollution control system

    Science.gov (United States)

    Wolverton, Billy C. (Inventor); Jarrell, Lamont (Inventor)

    1990-01-01

    A bioaquatic air pollution control system for controlling both water and atmospheric pollution is disclosed. The pollution control system includes an exhaust for directing polluted gases out of a furnace and a fluid circulating system which circulates fluid, such as waste water, from a source, past the furnace where the fluid flow entrains the pollutants from the furnace. The combined fluid and pollutants are then directed through a rock/plant/microbial filtering system. A suction pump pumps the treated waste water from the filter system past the exhaust to again entrain more pollutants from the furnace where they are combined with the fluid (waste water) and directed to the filter system.

  7. [Combined treatment: regimens, indications and safety profile].

    Science.gov (United States)

    Muñiz Grijalvo, Ovidio; Villar Ortiz, Jose

    2013-01-01

    Statins are the current basis of lipid-lowering therapy, despite which may have limitations on efficacy and safety. In high risk patients who do not achieve current lipid goals, in those intolerant to statins or those with atherogenic dyslipidemia, it is possible combine two or more lipid lowering drugs, including statins, ezetimibe, bile acid sequestrants, fibrates, niacin and prescription omega-3 fatty acids. However, for most of these combination therapies pivotal data on clinical outcomes are still lacking. Copyright © 2013 Elsevier España, S.L. and SEA. All rights reserved.

  8. Combined effect of external and internal irradiation

    International Nuclear Information System (INIS)

    Kiradzhiev, G.

    1987-01-01

    Some of the general regularities of the combined effect of external irradiation and iodine 131 are discussed. Data are adduced showing that modification of the effects of these two radiation factors, when jointly applied, is also determined by the quantitative relations of the applied doses of external and internal irradiation, referred to a particular moment of the effects. It was shown that the effects of the radionuclides in these combined radiation injuries are basically realized by two mechanisms: 1. changes are found in the radionuclide kinetic parameters (nonspecific effects); 2. changes in their kinetic parameters are absent (specific effect). These two mechanisms underlie different approaches to therapy

  9. PANSAID-PAracetamol and NSAID in combination

    DEFF Research Database (Denmark)

    Thybo, Kasper Højgaard; Jakobsen, Janus Christian; Hägi-Pedersen, Daniel

    2017-01-01

    BACKGROUND: Effective postoperative pain management is essential for the rehabilitation of the surgical patient. The PANSAID trial evaluates the analgesic effects and safety of the combination of paracetamol and ibuprofen. This paper describes in detail the statistical analysis plan for the primary...... publication to prevent outcome reporting bias and data-driven analysis results. METHODS/DESIGN: The PANSAID trial is a multicentre, randomised, controlled, parallel, four-group clinical trial comparing the beneficial and harmful effects of different doses and combinations of paracetamol and ibuprofen...... of paracetamol and ibuprofen used in a perioperative setting. TRIAL REGISTRATION: ClinicalTrials.org identifier: NCT02571361 . Registered on 7 October 2015....

  10. Abdominoplasty combined with other intraabdominal procedures.

    Science.gov (United States)

    Gemperli, R; Neves, R I; Tuma, P; Bonamichi, G T; Ferreira, M C; Manders, E K

    1992-07-01

    One hundred three patients underwent abdominoplasty combined with other intraabdominal procedures including 67 tubal ligations, 34 total abdominal hysterectomies and 2 cholecystectomies, from January 1983 to July 1991. The patients were divided into two groups, those undergoing the standard or total abdominoplasty and those undergoing limited abdominoplasty with or without liposuction in delimited areas. In this series of 103 patients, we found only two minor complications and only three patients were transfused with autologous units of blood. When performed by well-schooled surgical teams, abdominoplasty may be combined with intraabdominal procedures with gratifying results.

  11. Center for Hypersonic Combined Cycle Flow Physics

    Science.gov (United States)

    2015-03-24

    scales, the PaSR model may behave like a perfectly-stirred reactor (PSR) or a plug - flow reactor . In our PaSR analysis, the pair-wise mixing model...AFRL-AFOSR-VA-TR-2015-0292 CENTER FOR HYPERSONIC COMBINED CYCLE FLOW PHYSICS James Mcdaniel UNIVERSITY OF VIRGINIA Final Report 03/24/2015...HYPERSONIC COMBINED CYCLE FLOW PHYSICS 5a. CONTRACT NUMBER 5b. GRANT NUMBER FA9550-09-1-0611 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) McDaniel, James C

  12. Ectopic pregnancy treatment by combination therapy

    Directory of Open Access Journals (Sweden)

    Cymbaluk-Płoska Aneta

    2016-01-01

    Full Text Available Detectability of early stages of ectopic pregnancies has increased due to improvements in ultrasonographic and biochemical techniques. Since the patients’ future procreative plans must be taken into consideration when commencing treatment, the goal of this work was to compare the effects of treatment methods and their impact on fertility. The study included 91 patients treated surgically for ectopic pregnancy. The choice of treatment depended on patients’ general condition, ultrasonographic evaluation and serum level of beta-hCG. A combination of laparoscopic and conservative systemic treatment was applied in 70% of cases. More rapid beta-hCG reduction was noted when laparoscopy and intra-oviductal injection of hyperosmolar glucose or methotrexate (MTX were combined with intramuscular administration of MTX at a dose of 50 mg/m2. Follow-up examination of 66 patients revealed that the greatest number of spontaneous pregnancies (48% resulted after this combination therapy. We conclude that this combination treatment is safe and provides satisfactory results in terms of future fertility.

  13. Combined assessment (aspiration cytology and mammography) of ...

    African Journals Online (AJOL)

    We examined the safety and utility of the combined assessment of aspiration cytology and mammography in. 705 women who had clinically suspicious or malignant palpable breast masses. Histological assessment confirmed 176 benign and 529 malignant lesions. There were no incorrect (false positive) diagnoses made ...

  14. Learning Geography by Combining Fieldwork with GIS

    Science.gov (United States)

    Favier, Tim; van der Schee, Joop

    2009-01-01

    Geographic information systems (GIS) offer many possibilities for supporting student research projects. This paper deals with the results of the first phase of a design study on student research projects that combine (quantitative) data collection in the field with data visualisation, manipulation and analysis in GIS. In this study, we try to…

  15. Epidemiological association between osteoporosis and combined ...

    African Journals Online (AJOL)

    ... higher dietary calcium intake was negatively associated with osteoporosis. Conclusions: Based on these findings, it can be concluded that the combined lifetime use of both snuff and cigarettes may increase the odds of developing osteoporosis among women who are 40 years and older. Key words: Cigarette, nicotine, ...

  16. Combined central retinalartery and vein occlusion complicating ...

    African Journals Online (AJOL)

    Orbital Cellulitis is a dreaded ophthalmologic disease. Itmay destroy vision and the eye andmay even become life threatening. Often visual loss is the result of exposure and subsequent destruction of ocular tissue commonly the cornea and the uvea. We report a case of combined central retinal artery and vein occlusion ...

  17. Combined Effects of Aqueous Extracts of Tetracarpidium ...

    African Journals Online (AJOL)

    ADOWIE PERE

    ABSTRACT: This study evaluated the effect of combined treatment of aqueous extracts of Tetracarpidium conophorum (TCE) nuts and Vernonia ... The symptoms of diabetes include weight loss, polydisia (increased thirst), polyuria, ... from consuming as snacks, some studies on the plants have revealed that there is good ...

  18. 77 FR 31346 - Combined Notice of Filings

    Science.gov (United States)

    2012-05-25

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings: Filings Instituting Proceedings Docket Numbers: RP12-732-000. Applicants: Golden Triangle Storage, Inc...

  19. PANSAID-PAracetamol and NSAID in combination

    DEFF Research Database (Denmark)

    Thybo, Kasper Højgaard; Jakobsen, Janus Christian; Hägi-Pedersen, Daniel

    2017-01-01

    BACKGROUND: Effective postoperative pain management is essential for the rehabilitation of the surgical patient. The PANSAID trial evaluates the analgesic effects and safety of the combination of paracetamol and ibuprofen. This paper describes in detail the statistical analysis plan for the prima...

  20. Strength of Ship Plates under Combined Loading

    DEFF Research Database (Denmark)

    Cui, W.; Wang, Y.; Pedersen, Preben Terndrup

    2002-01-01

    . The obtained results indicate that the simplified analytical method is able to determine the ultimate strength of unstiffened plates with imperfections in the form of welding-induced residual stresses and geometric deflections subjected to combined loads. Comparisons with experimental results show...

  1. Strength of ship plates under combined loading

    DEFF Research Database (Denmark)

    Cui, Weiching; Wang, Yongjun; Pedersen, Preben Terndrup

    2000-01-01

    that the simplified method is able to determine the ultimate strength of unstiffened plates with imperfections in the form of welding induced residual stresses and geometric deflections subjected to combined loads. Comparisons with experimental results show that the procedure has sufficient accuracy for practical...

  2. Feature selection based classifier combination approach for ...

    Indian Academy of Sciences (India)

    based classifier combination is the simplest method in which final decision is that class for which maximum (greater than N/2) participating classifier vote, where N is the number of classifiers. 3.2b Decision templates: The method based on decision template, (Kuncheva et al 2001) firstly creates DT for each class using ...

  3. Combined matrices in special classes of matrices

    Czech Academy of Sciences Publication Activity Database

    Fiedler, Miroslav; Markham, T. L.

    2011-01-01

    Roč. 435, č. 8 (2011), s. 1945-1955 ISSN 0024-3795 Institutional research plan: CEZ:AV0Z10300504 Keywords : combined matrix * Hadamard product * positive definite matrix * M-matrix * totally positive matrix * oscillatory matrix * Cauchy matrix Subject RIV: BA - General Mathematics Impact factor: 0.974, year: 2011

  4. Feature selection based classifier combination approach for ...

    Indian Academy of Sciences (India)

    2016-08-26

    Aug 26, 2016 ... Feature selection based classifier combination approach for handwritten Devanagari numeral recognition. Pratibha Singh Ajay Verma ... ensemble of classifiers. The main contribution of the proposed method is that, the method gives quite efficient results utilizing only 10% patterns of the available dataset.

  5. A new combination in Lapanthus (Bromeliaceae).

    Science.gov (United States)

    Louzada, Rafael Batista; Wanderley, Maria das Graças Lapa

    2012-01-01

    A new combination, Lapanthus vidaliorum (O.B.C. Ribeiro & C.C. Paula) Louzada & Wand. is proposed for Orthophytum vidaliorum O.B.C. Ribeiro & C.C. Paula. In addition notes on taxonomy, geographic distribution and conservation are provided.

  6. A new combination in Lapanthus (Bromeliaceae

    Directory of Open Access Journals (Sweden)

    Rafael Louzada

    2012-10-01

    Full Text Available A new combination, Lapanthus vidaliorum (O.B.C. Ribeiro & C.C. Paula Louzada & Wand. is proposed for Orthophytum vidaliorum O. Ribeiro & C.C. Paula. In addition notes on taxonomy, geographic distribution and conservation are provided.

  7. Pharmacokinetics Of Artemether-Lumefantrine Combination ...

    African Journals Online (AJOL)

    Objectives: The therapeutic effects of artemether monotherapy compared to artemether-lumefantrine combined therapy in malaria based on their pharmacokinetic parameters such as absorption, elimination constants, area under the curve, bioavailability, volume of distribution and half-lives were investigated. Methods: ...

  8. Monthly sulphadoxine-pyrimethamine combination versus daily ...

    African Journals Online (AJOL)

    Monthly sulphadoxine-pyrimethamine combination versus daily proguanil for malaria chemoprophylaxis in sickle cell disease: a randomized controlled study at the Jos University Teaching Hospital. J.A. Dawam, J.K.A. Madaki, A.A. Gambazai, E.S. Okpe, N Lar-ndam, A Onu, M Gyang ...

  9. COMPARISON OF XYLAZINE, LIGNOCAINE AND COMBINATION ...

    African Journals Online (AJOL)

    with adrenaline 1:100,000 (Lidocaine 2%,. ASTRA Pharmaceutical Ltd, UK) at 2mg/kg and. ' a combination of xylazine (0.1mg/kg) and lignocaine (2mg/kg). Xylazine alone treatment was further diluted with normal saline to lml for injection into the epidural space. Prior to each trial the lumbosacral space was aseptically.

  10. Determination of hormonal combination for increased multiplication ...

    African Journals Online (AJOL)

    ACSS

    tested using a completely randomized design with three replicates in the tissue culture laboratory. Ten shoot tips from in-vitro raised .... Hormonal combination for increased multiplication of tissue culture potato plantlets trimmed off and the nodal explants ..... Comparison of hydroponic and aeroponics cultivation systems for ...

  11. Apparatus for combining oxygen and hydrogen

    International Nuclear Information System (INIS)

    Betz, E.C.

    1977-01-01

    An apparatus is described for catalytically combining hydrogen and oxygen which includes two concentric catalyst chambers arranged so that the outer chamber surrounds the inner chamber and the gas stream passes radially through the outer catalyst chamber. 10 claims, 2 figures

  12. Combination of scoring schemes for protein docking

    Directory of Open Access Journals (Sweden)

    Schomburg Dietmar

    2007-08-01

    Full Text Available Abstract Background Docking algorithms are developed to predict in which orientation two proteins are likely to bind under natural conditions. The currently used methods usually consist of a sampling step followed by a scoring step. We developed a weighted geometric correlation based on optimised atom specific weighting factors and combined them with our previously published amino acid specific scoring and with a comprehensive SVM-based scoring function. Results The scoring with the atom specific weighting factors yields better results than the amino acid specific scoring. In combination with SVM-based scoring functions the percentage of complexes for which a near native structure can be predicted within the top 100 ranks increased from 14% with the geometric scoring to 54% with the combination of all scoring functions. Especially for the enzyme-inhibitor complexes the results of the ranking are excellent. For half of these complexes a near-native structure can be predicted within the first 10 proposed structures and for more than 86% of all enzyme-inhibitor complexes within the first 50 predicted structures. Conclusion We were able to develop a combination of different scoring schemes which considers a series of previously described and some new scoring criteria yielding a remarkable improvement of prediction quality.

  13. Combination of Single Dish and Interferometer Data

    Science.gov (United States)

    Teuben, Peter; Burkutean, Sandra; Stanke, Thomas

    2018-03-01

    I will review techniques how to combine single dish and interferometric data in the radio regime. Packages such as MIRIAD and GILDAS will also be compared to how this is currently done in CASA. An associated tutorial will focus and compare solutions in CASA using the QAC frontend, for which scripts are available in the github repository.

  14. Aircraft Detectors, Trap Triggers and Combination Locks

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 5; Issue 2. Aircraft Detectors, Trap Triggers and Combination Locks - Functional Diversity of Insect Mechanosensory Hairs. Jürgen Tautz. General Article Volume 5 Issue 2 February 2000 pp 32-38 ...

  15. Combined antiretroviral and anti- tuberculosis drug resistance ...

    African Journals Online (AJOL)

    these epidemics, many challenges remain.[3] Antiretroviral and anti-TB drug resistance pose considerable threats to the control of these epidemics.[4,5]. The breakdown in HIV/TB control within prisons is another emerging threat.[6,7] We describe one of the first reports of combined antiretroviral and anti-TB drug resistance ...

  16. Estimated combined steady state tyre slip characteristics

    NARCIS (Netherlands)

    Fernandez, A.L.A.; Pauwelussen, J.P.

    2001-01-01

    Excessive behaviour of vehicles is often the subject of study, motivated by either the development of active safety systems uch as ESP, or the improvement of vehicle performance such as for racecars. In all of these cases, combined slip needs to be taken into account. In many cases however, the full

  17. Effectiveness of combined thermophilic composting and ...

    African Journals Online (AJOL)

    Vermicomposting (V) is also increasingly becoming popular. These two techniques have their inherent advantages and disadvantages. In this study, vermicomposting and a combination of thermophilic composting and vermicomposting were compared as ways of sanitizing and biodegrading dairy manure and waste paper ...

  18. Alcohol-pentazocine combination: implication on the ...

    African Journals Online (AJOL)

    Alcohol-pentazocine combination: implication on the cytoarchitectural profile of the medial prefrontal cortex and cerebellum of juvenile male rats. D.A. Adekomi, O.S. Adewole, B.J. Dare, O.O. Olaniyan, R.M. Ojebisi, M.S. Ajao ...

  19. Combining pharmacotherapy and psychotherapy - the example of ...

    African Journals Online (AJOL)

    The studies looking at the neurobiological effects of psychotherapy is reviewed and discussed. The practical aspects of combination therapy are presented and problems inherent are indicated and the effectiveness presented. Finally the Canadian Psychiatric Association's comprehensive evidence based clinical guideline ...

  20. Combinational Services for NGN based IPTV

    NARCIS (Netherlands)

    Mikóczy, E.; Schumann, S.; Stokking, H.M.; Deventer, M.O. van; Niamut, O.A.

    2009-01-01

    This paper describes the general concept of combinational/blended services for IP-based Television (IPTV) services in next generation networks towards its service oriented architecture concept (SOA). Besides introducing general approaches of service reusability (SOA concepts), the service enables

  1. Combining morphological analysis and Bayesian networks for ...

    African Journals Online (AJOL)

    ... how these two computer aided methods may be combined to better facilitate modelling procedures. A simple example is presented, concerning a recent application in the field of environmental decision support. Keywords: Morphological analysis, Bayesian networks, strategic decision support. ORiON Vol. 23 (2) 2007: pp.

  2. Successive combination jet algorithm for hadron collisions

    International Nuclear Information System (INIS)

    Ellis, S.D.; Soper, D.E.

    1993-01-01

    Jet finding algorithms, as they are used in e + e- and hadron collisions, are reviewed and compared. It is suggested that a successive combination style algorithm, similar to that used in e + e- physics, might be useful also in hadron collisions, where cone style algorithms have been used previously

  3. Determining large deflections in rectangular combined loaded ...

    Indian Academy of Sciences (India)

    Abstract. In this study, large deflection of cantilever beams of Ludwick type material subjected to a combined loading consisting of a uniformly distributed load and one vertical concentrated load at the free end was investigated. In calcula- tions, both material and geometrical non-linearity have been considered. Horizon-.

  4. Antiemetic effects of dexamethasone and ondansetron combination ...

    African Journals Online (AJOL)

    Background: Nausea and vomiting are frequently seen in patients undergoing cesarean section (CS) under regional anesthesia. We aimed to compare the antiemetic efficacy of ondansetron and dexamethasone combination with that of the use of each agent alone to decrease the incidence of post-delivery intraoperative ...

  5. Modified function projective combination synchronization of ...

    Indian Academy of Sciences (India)

    Modified function projective synchronization between the newly constructed combination hyperchaotic Lorenz system and hyperchaotic Lu system is investigated using adaptive method. By Lyapunov stability theory, the adaptive control law and the parameter update law are derived to make the state of two systems as ...

  6. Synergistic drug combinations improve therapeutic selectivity

    Science.gov (United States)

    Lehàr, Joseph; Krueger, Andrew S.; Avery, William; Heilbut, Adrian M.; Johansen, Lisa M.; Price, E. Roydon; Rickles, Richard J.; Short, Glenn F.; Staunton, Jane E.; Jin, Xiaowei; Lee, Margaret S.; Zimmermann, Grant R.; Borisy, Alexis A.

    2009-01-01

    Prevailing drug discovery approaches focus on compounds with molecular selectivity, inhibiting disease-relevant targets over others in vitro. However in vivo, many such agents are not therapeutically selective, either because of undesirable activity at effective doses or because the biological system responds to compensate. In theory, drug combinations should permit increased control of such complex biology, but there is a common concern that therapeutic synergy will generally be mirrored by synergistic side-effects. Here we provide evidence, from 94,110 multi-dose combination experiments representing diverse disease areas and large scale flux balance simulations of inhibited bacterial metabolism, that multi-target synergies are more specific than single agent activities to particular cellular contexts. Using an anti-inflammatory combination, we show how multi-target synergy can achieve therapeutic selectivity in animals through differential target expression. Synergistic combinations can increase the number of selective therapies using the current pharmacopeia, and offer opportunities for more precise control of biological systems. PMID:19581876

  7. A Novel in situ Trigger Combination Method

    International Nuclear Information System (INIS)

    Buzatu, Adrian; Warburton, Andreas; Krumnack, Nils; Yao, Wei-Ming

    2012-01-01

    Searches for rare physics processes using particle detectors in high-luminosity colliding hadronic beam environments require the use of multi-level trigger systems to reject colossal background rates in real time. In analyses like the search for the Higgs boson, there is a need to maximize the signal acceptance by combining multiple different trigger chains when forming the offline data sample. In such statistically limited searches, datasets are often amassed over periods of several years, during which the trigger characteristics evolve and their performance can vary significantly. Reliable production cross-section measurements and upper limits must take into account a detailed understanding of the effective trigger inefficiency for every selected candidate event. We present as an example the complex situation of three trigger chains, based on missing energy and jet energy, to be combined in the context of the search for the Higgs (H) boson produced in association with a W boson at the Collider Detector at Fermilab (CDF). We briefly review the existing techniques for combining triggers, namely the inclusion, division, and exclusion methods. We introduce and describe a novel fourth in situ method whereby, for each candidate event, only the trigger chain with the highest a priori probability of selecting the event is considered. The in situ combination method has advantages of scalability to large numbers of differing trigger chains and of insensitivity to correlations between triggers. We compare the inclusion and in situ methods for signal event yields in the CDF WH search.

  8. Effectiveness of combined thermophilic composting and ...

    African Journals Online (AJOL)

    USER

    2010-07-26

    Jul 26, 2010 ... Intensive livestock farming,. *Corresponding author. E-mail: PMnkeni@ufh.ac.za. Abbreviations: HR, Humification ratio; HI, humification index;. MC, moisture content; CV, combined vermicomposting; CHA, extractable humic acid carbon; CFA, extractable fulvic acid carbon; EC, electrical conductivity; VS, ...

  9. UV-T-RH combined environmental testing

    Science.gov (United States)

    Gonzalez, C. C.

    1986-01-01

    A combined environmental aging chamber was developed at the Jet Propulsion Laboratory (JPL). The chamber has an ultraviolet (UV) light source that can be varied between 1 to 2 suns, temperature control from -40 to +175 C, and adjustable humidity. Results from two initial aging experiments (Tedlar and amorphous silicon colar cells) were presented.

  10. Seeing double: combined modalities in functional imaging

    Energy Technology Data Exchange (ETDEWEB)

    Del Guerra, A. E-mail: delguerra@pi.infn.it; Damiani, C.; Di Domenico, G.; Gambaccini, M.; Motta, A.; Sabba, N.; Zavattini, G

    2001-09-21

    Various dedicated instruments for combined modalities in functional imaging are being developed by our group: a small animal PET/SPECT scanner, two scintimammography apparatus for breast cancer diagnosis, one with RX/PEM and the other with RX/SPECT capability. The performance and the status of development of these devices will be reported.

  11. Learning geography by combining fieldwork with GIS

    NARCIS (Netherlands)

    Favier, T.T.; van der Schee, J.A.

    2009-01-01

    Geographie information systems (GIS) offer many possibilities for supporting student research projects. This paper deals with the results of the first phase of a design study on student research projects that combine (quantitative) data collection in the field with data visualisation, manipulation

  12. Steam plant: Steam turbines for combined cycles

    Science.gov (United States)

    Schrieken, J.

    Parameters affecting steam turbines design are discussed and it is concluded that steam turbines for combined cycles are suitable for: powers between 1 and 250 MW; driving a generator, via a gearbox if necessary; drive through of powers which can be up to three times their own power; and ground level installation with up, side, or axial exhaust for condensing turbine applications. Parameters affecting the steam turbine performance are discussed: inlet conditions and flows, sliding inlet conditions, reheat cycles, fired and unfired heat recovery steam generators, cogeneration systems, and combined cycle for process steam supply. Aerodynamic design aspects of steam turbines for combined cycles are discussed. It is concluded that steam turbines for combined cycles have a large range of special requirements. Some typical aspects are: large exhaust annular areas and special exhaust arrangements for condensing steam turbines, drive through of the power of the gas turbines, high influence on the total cycle performance optimization, and a wide variety of extraction systems for cogeneration.

  13. 77 FR 60418 - Combined Notice of Filings

    Science.gov (United States)

    2012-10-03

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings...-1064-000. Applicants: Venice Gathering System, L.L.C. Description: NAESB 2.0 Compliance Filing to be...

  14. 77 FR 71408 - Combined Notice of Filings

    Science.gov (United States)

    2012-11-30

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings....m. ET 12/3/12. Docket Numbers: RP13-301-000. Applicants: Venice Gathering System, LLC. Description...

  15. 76 FR 61352 - Combined Notice of Filings

    Science.gov (United States)

    2011-10-04

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings....m. Eastern Time on Wednesday, October 05, 2011. Docket Numbers: RP11-2585-000. Applicants: Venice...

  16. 76 FR 55375 - Combined Notice of Filings

    Science.gov (United States)

    2011-09-07

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings..., September 12, 2011. Docket Numbers: RP11-2454-000. Applicants: Venice Gathering System, LLC. Description...

  17. 75 FR 39230 - Combined Notice of Filings

    Science.gov (United States)

    2010-07-08

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings July 1, 2010. Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report..., July 12, 2010. Docket Numbers: RP10-922-000. Applicants: Venice Gathering System, LLC. Description...

  18. 76 FR 353 - Combined Notice of Filings

    Science.gov (United States)

    2011-01-04

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings December 22, 2010. Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund... 3, 2011. Docket Numbers: RP11-1640-000. Applicants: Venice Gathering System, L.L.C. Description...

  19. 78 FR 50408 - Combined Notice of Filings

    Science.gov (United States)

    2013-08-19

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings... Numbers: RP13-1239-000. Applicants: Venice Gathering System, L.L.C. Description: Order No. 776 Compliance...

  20. 76 FR 39085 - Combined Notice of Filings

    Science.gov (United States)

    2011-07-05

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Combined Notice of Filings Take notice that the Commission has received the following Natural Gas Pipeline Rate and Refund Report filings..., July 05, 2011. Docket Numbers: RP11-2205-000. Applicants: Venice Gathering System, LLC. Description...

  1. Combined Heat and Power and Emissions Trading

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-07-01

    The aim of this IEA Information Paper is to help policy makers and other stakeholders understand the challenges facing the incorporation of high efficiency combined heat and power (CHP) into greenhouse gas (GHG) Emissions Trading Schemes (ETSs) -- and to propose options for overcoming them.

  2. Effects of combination of ethylenediaminetetraacetic acid and ...

    African Journals Online (AJOL)

    This experiment was conducted to evaluate the combined effects of ethylene diamine tetraacetic acid (EDTA) and microbial phytase (MP) on the serum concentration and digestibility of some minerals in broiler chicks. This experiment was conducted using 360 Ross-308 male broiler chicks in a completely randomized ...

  3. Dempster Combination Rule for Signed Belief Functions

    Czech Academy of Sciences Publication Activity Database

    Kramosil, Ivan

    1998-01-01

    Roč. 6, č. 1 (1998), s. 79-102 ISSN 0218-4885 R&D Projects: GA AV ČR IAA1030504 Keywords : probability space * signed measure * belief function * signed belief function * Dempster combination rule Subject RIV: BA - General Mathematics

  4. Combined optical/digital security devices

    Science.gov (United States)

    Girnyk, Vladimir I.; Tverdokhleb, Igor V.; Ivanovsky, Andrey A.

    2000-04-01

    Modern holographic security devices used as emblems against counterfeiting are being more difficult as they should oppress criminal world. 2D, 3D, 3D rainbow holograms or simple diffraction structures protecting documents can not be acceptable against illegal copying of important documents, banknotes or valuable products. Recent developments in technology of Optical variable devices permit world leaders to create more advanced security elements: Kinegrams, Exelgrams, Pixelgrams, Kineforms. These products are used for protecting the most confidential documents and banknotes, but now even their security level can not be enough and besides their automatic identification is vulnerable to factors of instability. We elaborate new visual security devices based on the usage of expensive and advanced technology of combined optical/digital security devices. The technology unites digital and analogue methods of synthesis and recording of visual security devices. The analogue methods include techniques of optical holography - different combinations of 2D/3D, 3D, 2D/3D + 3D structures. Basing on them the design with elements of 3D graphics including security elements and hidden machine- readable images are implemented. The digital methods provide synthesis of optical variable devices including special security elements, computer generated holograms and Kineforms. Using them we create determined and quasi-random machine-readable images. Recordings are carried out using the combined optical and electronic submicrometer technology elaborated by Optronics, Ltd. The results obtained show effectiveness of the combined technology permitting to increase the security level essentially that should increase tamper and counterfeit resistance during many years.

  5. Combination of radiation injuries: pathogenesis, clinic, therapy

    International Nuclear Information System (INIS)

    Tsyba, A.F.; Farshatova, M.N.

    1993-01-01

    Modern notions on combined radiation injuries (CRI) are presented. Characteristic of injurious factors of nuclear explosion and common regularities of the CRI origination is given. The data on the CRI clinical peculiarities, diagnostics and treatment, principles of medical assistance for the injured on the stages of medical evacuation and recommendations on rehabilitation are presented

  6. Combinations of bacterial species in endodontic infections

    NARCIS (Netherlands)

    Peters, LB; Wesselink, P.R.; van Winkelhoff, AJ

    Aim This study was undertaken to investigate combinations of bacteria found in root-canal infections of teeth with periapical bone destruction without clinical signs and symptoms. Methodology Endodontic samples from 58 root canals were cultured anaerobically and microorganisms were counted and

  7. Combination of ATLAS Higgs Boson measurements

    CERN Document Server

    Monticelli, Fernando; The ATLAS collaboration

    2018-01-01

    The results obtained from the different decay channels are combined to study the properties of the Higgs boson mass, production and decay, and test the SM theoretical precision with increased accuracy, using about 36 fb^{-1} of p-p collisions data collected at 13 TeV.

  8. Effects of combination of ethylenediaminetetraacetic acid and ...

    African Journals Online (AJOL)

    Administrator

    2010-12-27

    Dec 27, 2010 ... This experiment was conducted to evaluate the combined effects of ethylene diamine tetraacetic acid. (EDTA) and microbial phytase (MP) on the serum concentration and digestibility of some minerals in broiler chicks. This experiment was conducted using 360 Ross-308 male broiler chicks in a completely.

  9. Combined administration of Spondias mombin and Ficus ...

    African Journals Online (AJOL)

    Combined administration of Spondias mombin and Ficus exasperata leaf extracts stall Indomethacin-mediated gastric mucosal onslaught in rats. ... The extracts also effectively attenuated the reduced activities of superoxide dismutase and catalase as well as pH, mucin content and reduced glutathione level in the ulcerated ...

  10. Combining Ability and Heterotic Relationships between CIMMYT ...

    African Journals Online (AJOL)

    effects of Ethiopian and CIMMYT maize inbred lines for grain yield and some agronomic traits; and .... Although biplot have been primarily used for analysing multi-environment cultivar trials and ... Combined analysis of variance for the tested traits in a North Carolina Design II mating between Ethiopian and CIMMYT maize ...

  11. Feature selection based classifier combination approach for ...

    Indian Academy of Sciences (India)

    3.2c Dempster-Shafer rule based classifier combination: Dempster–Shafer (DS) method is based on the evidence theory, proposed by Glen Shafer as a way to represent cognitive knowledge. Here the probability is obtained using belief function instead of using the Bayesian distribution. Prob- ability values are assigned to a ...

  12. Towards combined global monthly gravity field solutions

    Science.gov (United States)

    Jaeggi, Adrian; Meyer, Ulrich; Beutler, Gerhard; Weigelt, Matthias; van Dam, Tonie; Mayer-Gürr, Torsten; Flury, Jakob; Flechtner, Frank; Dahle, Christoph; Lemoine, Jean-Michel; Bruinsma, Sean

    2014-05-01

    Currently, official GRACE Science Data System (SDS) monthly gravity field solutions are generated independently by the Centre for Space Research (CSR) and the German Research Centre for Geosciences (GFZ). Additional GRACE SDS monthly fields are provided by the Jet Propulsion Laboratory (JPL) for validation and outside the SDS by a number of other institutions worldwide. Although the adopted background models and processing standards have been harmonized more and more by the various processing centers during the past years, notable differences still exist and the users are more or less left alone with a decision which model to choose for their individual applications. This procedure seriously limits the accessibility of these valuable data. Combinations are well established in the area of other space geodetic techniques, such as the Global Navigation Satellite Systems (GNSS), Satellite Laser Ranging (SLR), and Very Long Baseline Interferometry (VLBI). Regularly comparing and combining space-geodetic products has tremendously increased the usefulness of the products in a wide range of disciplines and scientific applications. Therefore, we propose in a first step to mutually compare the large variety of available monthly GRACE gravity field solutions, e.g., by assessing the signal content over selected regions, by estimating the noise over the oceans, and by performing significance tests. We make the attempt to assign different solution characteristics to different processing strategies in order to identify subsets of solutions, which are based on similar processing strategies. Using these subsets we will in a second step explore ways to generate combined solutions, e.g., based on a weighted average of the individual solutions using empirical weights derived from pair-wise comparisons. We will also assess the quality of such a combined solution and discuss the potential benefits for the GRACE and GRACE-FO user community, but also address minimum processing

  13. PHARMACOECONOMIC ANALYSIS OF ANTIHYPERTENSIVE DRUG COMBINATIONS USE

    Directory of Open Access Journals (Sweden)

    E. I. Tarlovskaya

    2014-01-01

    Full Text Available Aim. To pursue pharmacoeconomic analysis of two drug combinations of ACE inhibitor (enalapril and diuretic.Material and methods. Patients with arterial hypertension degree 2 and diabetes mellitus type 2 without ischemic heart disease (n=56 were included into the study. Blood pressure (BP dynamics and cost/effectiveness ratio were evaluated.Results. In group A (fixed combination of original enalapril/hydrochlorothiazide 61% of patients achieved target BP level with initial dose, and the rest 39% of patients – with double dose. In group B (non-fixed combination of generic enalapril/indapamide 60% of patients achieved the target BP with initial dose of drugs, 33% - with double dose of ACE inhibitor, and 7% - with additional amlodipine administration. In patients of group A systolic BP (SBP reduction was 45.82±1.23 mm Hg by the 12th week vs. 40.0±0.81 mm Hg in patients of group B; diastolic BP (DBP reduction was 22.47±1.05 mm Hg and 18.76±0.70 mm Hg, respectively, by the 12th week of treatment. In the first month of treatment costs of target BP achievement was 298.62 rubles per patient in group A, and 299.50 rubles – in group B; by the 12th week of treatment – 629.45 and 631.22 rubles, respectively. Costs of SBP and DBP reduction by 1 mm Hg during 12 weeks of therapy were 13 and 27 rubles per patient, respectively, in group A, and 16 and 34 rubles per patient, respectively, in group B.Conclusion. The original fixed combination (enalapril+hydrochlorothiazide proved to be more clinically effective and more cost effective in the treatment of hypertensive patients in comparison with the non-fixed combination of generic drugs (enalapril+indapamide.

  14. PHARMACOECONOMIC ANALYSIS OF ANTIHYPERTENSIVE DRUG COMBINATIONS USE

    Directory of Open Access Journals (Sweden)

    E. I. Tarlovskaya

    2015-09-01

    Full Text Available Aim. To pursue pharmacoeconomic analysis of two drug combinations of ACE inhibitor (enalapril and diuretic.Material and methods. Patients with arterial hypertension degree 2 and diabetes mellitus type 2 without ischemic heart disease (n=56 were included into the study. Blood pressure (BP dynamics and cost/effectiveness ratio were evaluated.Results. In group A (fixed combination of original enalapril/hydrochlorothiazide 61% of patients achieved target BP level with initial dose, and the rest 39% of patients – with double dose. In group B (non-fixed combination of generic enalapril/indapamide 60% of patients achieved the target BP with initial dose of drugs, 33% - with double dose of ACE inhibitor, and 7% - with additional amlodipine administration. In patients of group A systolic BP (SBP reduction was 45.82±1.23 mm Hg by the 12th week vs. 40.0±0.81 mm Hg in patients of group B; diastolic BP (DBP reduction was 22.47±1.05 mm Hg and 18.76±0.70 mm Hg, respectively, by the 12th week of treatment. In the first month of treatment costs of target BP achievement was 298.62 rubles per patient in group A, and 299.50 rubles – in group B; by the 12th week of treatment – 629.45 and 631.22 rubles, respectively. Costs of SBP and DBP reduction by 1 mm Hg during 12 weeks of therapy were 13 and 27 rubles per patient, respectively, in group A, and 16 and 34 rubles per patient, respectively, in group B.Conclusion. The original fixed combination (enalapril+hydrochlorothiazide proved to be more clinically effective and more cost effective in the treatment of hypertensive patients in comparison with the non-fixed combination of generic drugs (enalapril+indapamide.

  15. Combination N-Way Power Divider/Combiner and Noninvasive Reflected Power Detection

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — An N-way RF/microwave power divider/combiner utilizes one input and N outputs, or conversely N inputs and one output to divide (or combine) RF/microwave power while...

  16. The Strutjet Rocket Based Combined Cycle Engine

    Science.gov (United States)

    Siebenhaar, A.; Bulman, M. J.; Bonnar, D. K.

    1998-01-01

    The multi stage chemical rocket has been established over many years as the propulsion System for space transportation vehicles, while, at the same time, there is increasing concern about its continued affordability and rather involved reusability. Two broad approaches to addressing this overall launch cost problem consist in one, the further development of the rocket motor, and two, the use of airbreathing propulsion to the maximum extent possible as a complement to the limited use of a conventional rocket. In both cases, a single-stage-to-orbit (SSTO) vehicle is considered a desirable goal. However, neither the "all-rocket" nor the "all-airbreathing" approach seems realizable and workable in practice without appreciable advances in materials and manufacturing. An affordable system must be reusable with minimal refurbishing on-ground, and large mean time between overhauls, and thus with high margins in design. It has been suggested that one may use different engine cycles, some rocket and others airbreathing, in a combination over a flight trajectory, but this approach does not lead to a converged solution with thrust-to-mass, specific impulse, and other performance and operational characteristics that can be obtained in the different engines. The reason is this type of engine is simply a combination of different engines with no commonality of gas flowpath or components, and therefore tends to have the deficiencies of each of the combined engines. A further development in this approach is a truly combined cycle that incorporates a series of cycles for different modes of propulsion along a flight path with multiple use of a set of components and an essentially single gas flowpath through the engine. This integrated approach is based on realizing the benefits of both a rocket engine and airbreathing engine in various combinations by a systematic functional integration of components in an engine class usually referred to as a rocket-based combined cycle (RBCC) engine

  17. Combined additive manufacturing approaches in tissue engineering.

    Science.gov (United States)

    Giannitelli, S M; Mozetic, P; Trombetta, M; Rainer, A

    2015-09-01

    Advances introduced by additive manufacturing (AM) have significantly improved the control over the microarchitecture of scaffolds for tissue engineering. This has led to the flourishing of research works addressing the optimization of AM scaffolds microarchitecture to optimally trade-off between conflicting requirements (e.g. mechanical stiffness and porosity level). A fascinating trend concerns the integration of AM with other scaffold fabrication methods (i.e. "combined" AM), leading to hybrid architectures with complementary structural features. Although this innovative approach is still at its beginning, significant results have been achieved in terms of improved biological response to the scaffold, especially targeting the regeneration of complex tissues. This review paper reports the state of the art in the field of combined AM, posing the accent on recent trends, challenges, and future perspectives. Copyright © 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  18. FOXN1 deficient nude severe combined immunodeficiency.

    Science.gov (United States)

    Rota, Ioanna A; Dhalla, Fatima

    2017-01-11

    Nude severe combined immunodeficiency is a rare inherited disease caused by autosomal recessive loss-of-function mutations in FOXN1. This gene encodes a transcription factor essential for the development of the thymus, the primary lymphoid organ that supports T-cell development and selection. To date nine cases have been reported presenting with the clinical triad of absent thymus resulting in severe T-cell immunodeficiency, congenital alopecia universalis and nail dystrophy. Diagnosis relies on testing for FOXN1 mutations, which allows genetic counselling and guides therapeutic management. Options for treating the underlying immune deficiency include HLA-matched genoidentical haematopoietic cell transplantation containing mature donor T-cells or thymus tissue transplantation. Experience from other severe combined immune deficiency syndromes suggests that early diagnosis, supportive care and definitive management result in better patient outcomes. Without these the prognosis is poor due to early-onset life threatening infections.

  19. Combining resummed Higgs predictions across jet bins

    Energy Technology Data Exchange (ETDEWEB)

    Boughezal, Radja [Argonne National Laboratory, IL (United States). High Energy Physics Division; Liu, Xiaohui; Petriello, Frank [Argonne National Laboratory, IL (United States). High Energy Physics Division; Northwestern Univ., Evanston, IL (United States). Dept. of Physics and Astronomy; Tackmann, Frank J. [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Walsh, Jonathan R. [California Univ., Berkeley, CA (United States). Ernest Orlando Lawrence Berkeley Laboratory; California Univ., Berkeley, CA (United States). Center for Theoretical Physics

    2013-12-15

    Experimental analyses often use jet binning to distinguish between different kinematic regimes and separate contributions from background processes. To accurately model theoretical uncertainties in these measurements, a consistent description of the jet bins is required. We present a complete framework for the combination of resummed results for production processes in different exclusive jet bins, focusing on Higgs production in gluon fusion as an example. We extend the resummation of the H+1-jet cross section into the challenging low transverse momentum region, lowering the uncertainties considerably. We provide combined predictions with resummation for cross sections in the H+0-jet and H+1-jet bins, and give an improved theory covariance matrix for use in experimental studies. We estimate that the relevant theoretical uncertainties on the signal strength in the H{yields}WW{sup *} analysis are reduced by nearly a factor of 2 compared to the current value.

  20. Roles for Innate Immunity in Combination Immunotherapies.

    Science.gov (United States)

    Moynihan, Kelly D; Irvine, Darrell J

    2017-10-01

    Immunity to infectious agents involves a coordinated response of innate and adaptive immune cells working in concert, with many feed-forward and regulatory interactions between both arms of the immune system. In contrast, many therapeutic strategies to augment immunity against tumors have focused predominantly on stimulation of adaptive immunity. However, a growing appreciation of the potential contributions of innate immune effectors to antitumor immunity, especially in the context of combination immunotherapy, is leading to novel strategies to elicit a more integrated immune response against cancer. Here we review antitumor activities of innate immune cells, mechanisms of their synergy with adaptive immune responses against tumors, and discuss recent studies highlighting the potential of combination therapies recruiting both innate and adaptive immune effectors to eradicate established tumors. Cancer Res; 77(19); 5215-21. ©2017 AACR . ©2017 American Association for Cancer Research.

  1. Combination radial and thrust magnetic bearing

    Science.gov (United States)

    Blumenstock, Kenneth A. (Inventor)

    2002-01-01

    A combination radial and thrust magnetic bearing is disclosed that allows for both radial and thrust axes control of an associated shaft. The combination radial and thrust magnetic bearing comprises a rotor and a stator. The rotor comprises a shaft, and first and second rotor pairs each having respective rotor elements. The stator comprises first and second stator elements and a magnet-sensor disk. In one embodiment, each stator element has a plurality of split-poles and a corresponding plurality of radial force coils and, in another embodiment, each stator element does not require thrust force coils, and radial force coils are replaced by double the plurality of coils serving as an outer member of each split-pole half.

  2. Suction caissons subjected to monotonic combined loading

    DEFF Research Database (Denmark)

    Penzes, P.; Jensen, M.R.; Zania, Varvara

    2016-01-01

    Suction caissons are being increasingly used as offshore foundation solutions in shallow and intermediate water depths. The convenient installation method through the application of suction has rendered this type of foundation as an attractive alternative to the more traditional monopile foundation...... for offshore wind turbines. The combined loading imposed typically to a suction caisson has led to the estimation of their bearing capacity by means of 3D failure envelopes. This study aims to analyse the behaviour of suction caissons for offshore wind turbines subjected to combined loading. Finite element...... models of the caisson-soil are developed in order to derive the failure envelopes considering both sand and clay profiles. The numerical modelling is being validated by the failure mechanisms reported in the literature for skirted foundations. The sensitivity of the load response curves on the selection...

  3. Control Flow Analysis for SF Combinator Calculus

    Directory of Open Access Journals (Sweden)

    Martin Lester

    2015-12-01

    Full Text Available Programs that transform other programs often require access to the internal structure of the program to be transformed. This is at odds with the usual extensional view of functional programming, as embodied by the lambda calculus and SK combinator calculus. The recently-developed SF combinator calculus offers an alternative, intensional model of computation that may serve as a foundation for developing principled languages in which to express intensional computation, including program transformation. Until now there have been no static analyses for reasoning about or verifying programs written in SF-calculus. We take the first step towards remedying this by developing a formulation of the popular control flow analysis 0CFA for SK-calculus and extending it to support SF-calculus. We prove its correctness and demonstrate that the analysis is invariant under the usual translation from SK-calculus into SF-calculus.

  4. Multi combined Adlerian supervision in Counseling

    OpenAIRE

    Gungor, Abdi

    2017-01-01

    For counselor professional and counselor education, supervision is an important process, in which more experienced professional helps and guides less experienced professional. To provide an effective and beneficial supervision, various therapy, development, or process based approaches and models have been developed. In addition, different eclectic models integrating more than one model have been developed. In this paper, as a supervision model, multi combined Adlerian supervision model is pro...

  5. Combined analog-to-digital converter

    International Nuclear Information System (INIS)

    Zhukov, A.V.; Rzhendinskaya, S.N.

    1983-01-01

    A 10-bit analog-to-digital converter (ADC) designed for operating in spectrometers with time-dependent filters is described. The ADC operation is based on combining the parallel reading and sequential counting methods. At maximum conversion time of 12 μs, timing series frequency of 25 MHz and foUr reference levels the differential nonlinearity withoUt statistical smoothing (maximum relative channel width deviation from average value) is not more than 4%

  6. Combining GLP-1 receptor agonists with insulin

    DEFF Research Database (Denmark)

    Holst, Jens Juul; Vilsbøll, T

    2013-01-01

    Due to the increasing prevalence of type 2 diabetes mellitus (T2DM), the emergent trend towards diagnosis in younger patients and the progressive nature of this disease, many more patients than before now require insulin to maintain glycaemic control. However, there is a degree of inertia among...... for using GLP-1RA and insulin therapies in combination is discussed, and data from clinical studies that have assessed the efficacy and safety of this treatment strategy are outlined....

  7. An exceptional combination of congenital coronary anomalies.

    Science.gov (United States)

    Kharrat, Ilyes; El-Fassy, Eric; Amabile, Nicolas

    2012-01-01

    We present a case of congenital coronary artery anomalies combining the absence of the circumflex artery, ectopic origins of left anterior descending and diagonal arteries and abnormal courses of these vessels. These rare anomalies were detected during an elective coronary angiography in a patient with stable angina that was related to significant stenosis of the posterolateral and middle right coronary artery. A computed tomography scanner with three-dimensional reconstructions confirmed the anatomy. Copyright © 2011 Wiley Periodicals, Inc.

  8. Combined interferometric and polarimetric diagnostics for TEXTOR

    International Nuclear Information System (INIS)

    Soltwisch, H.

    1980-01-01

    A method for combining Faraday rotation measurements with a phase modulated HCN interferometer is described. Extended to a multichannel system this technique should allow to investigate the distributions of electron density and poloidal magnetic field in a Tokamak plasma. We discuss the principle of operation and appropriate evaluation of measured data with regard to TEXTOR parameters and give an estimate for the expected experimental accuracy. (orig./GG) 891 GG/orig.- 892 KN

  9. Cost allocation. Combined heat and power production

    International Nuclear Information System (INIS)

    Sidzikauskas, V.

    2002-01-01

    The benefits of Combined Heat and Power (CHP) generation are discussed. The include improvement in energy intensity of 1% by 2010, 85-90% efficiency versus 40-50% of condensation power and others. Share of CHP electricity production in ERRA countries is presented.Solutions for a development CHP cost allocation are considered. Conclusion are presented for CHP production cost allocation. (R.P.)

  10. Combining data in non-destructive testing

    International Nuclear Information System (INIS)

    Lavayssiere, B.

    1994-03-01

    Non-destructive testing of some components requires quite often the use of several methods such as X-ray, ultrasonics, Eddy Currents. But the efficiency of a NDT method is highly dependent on the fact that the detectability of flaws in a specimen relies on the choice of the best method. Moreover a lot of inspection issues could benefit from the use of more than one test method, as each NDT method has its own physical properties and technological limits. Some questions still remain: how to combine data, at what level and for what functionality. Simple monomethod processes are well-known now. They include techniques like reconstruction which belongs to the so-called ill-posed problems in the field of mathematics. For NDT data processing, it has the ability to estimate real data from distorted ones coming from a probe. But, up to now there has been very few approaches for computer aided combination of results from different advanced techniques. This report presents the various mathematical fields involved towards that goal (statistical decision theory which allows the use of multiple hypothesis, non-linear decision theory for its capability to classify and to discriminate, graph theory to find the optimal path in an hypothesis graph and also fuzzy logic, multiple resolution analysis, artificial intelligence,...) and which combinations of methods are useful. Some images will illustrate this topic in which EDF is involved, and will explain what are the major goals of this work. Combining is not only an improvement of 3D visualisation which would allow to display simultaneously CAD or NDT data for example, but it consists in exploiting multisensor data collected via a variety of sophisticated techniques and presenting this information to the operator without overloading the operator/system capacities in order to reduce the uncertainty and to resolve the ambiguity inherent to mono method inspection. (author). 7 figs., 35 refs

  11. NASTRAN GPWG tables for combined substructures

    Science.gov (United States)

    Allen, Tom

    1991-01-01

    A method for computing the mass and center of gravity for basic and combined substructures stored in the NASTRAN Substructure Operating File (SOF) is described. The three step method recovers SOF data blocks for the relevant substructure, processes these data blocks using a specially developed FORTRAN routine, and generates the NASTRAN gridpoint weight generator (GPWG) table for the substructure in a PHASE2 SOF execution using a Direct Matrix Abstraction Program (DMAP) sequence. Verification data for the process is also provided.

  12. Combination of irradiation and thermal processing

    International Nuclear Information System (INIS)

    Hozova, B.; Sorman, L.

    1991-01-01

    Recently, the technology and methods of food preservation have searched for ever better and less destructive methods and procedures which prolong the shelf-life of the primary products so that they do not undergo degradation processes. New non-traditional methods of preservation, as well as the procedures based on scientifically controlled combination of two or more preservation methods give increasingly higher chances for the improvement of the quality of canned products. Such combinations should reduce the intensity of the adverse effects of separately applied preservation methods. The aim is to achieve synergic or additive effects of the decisive factors, which would ensure microbiological adequacy and storage stability of canned foods, including maximum retention of their nutritional and sensory characteristics. If the published scientific papers dealing with non-traditional methods of food preservation and application of combination of preservation methods are evaluated, it can be seen that there is no work which provides an analysis of this problem. The use of ionizing radiation can reduce the number of microorganisms on foods and doses of up to 10 kGy are not considered to present any toxicological risks. However results have not been satisfactory mainly due to the interaction of ionizing radiation with the components of the irradiated foods. It is desirable to reduce the side effects of radiosterilizing doses by reducing the dose and using another method to complete the processing. Special attention is paid particularly to the use of combinations of heat and irradiation, since this is suitable mainly for the preservation of meat products but can also be applied to vegetables and other products. (author)

  13. Chapter 23: Combined Heat and Power

    Energy Technology Data Exchange (ETDEWEB)

    Simons, George [Itron, Davis, CA (United States); Barsun, Stephan [Itron, Davis, CA (United States)

    2016-11-01

    This protocol defines a combined heat and power (CHP) measure as a system that sequentially generates both electrical energy and useful thermal energy from one fuel source at a host customer's facility or residence. This protocol is aimed primarily at regulators and administrators of ratepayer-funded CHP programs; however, project developers may find the protocol useful to understand how CHP projects are evaluated.

  14. Estimation of combined sewer overflow discharge

    DEFF Research Database (Denmark)

    Ahm, Malte; Thorndahl, Søren Liedtke; Nielsen, Jesper Ellerbæk

    2016-01-01

    Combined sewer overflow (CSO) structures are constructed to effectively discharge excess water during heavy rainfall, to protect the urban drainage system from hydraulic overload. Consequently, most CSO structures are not constructed according to basic hydraulic principles for ideal measurement w...... complex CSO structures. The three concepts was tested and verified under real practical conditions. All three concepts were accurate when compared to electromagnetic flow measurements....

  15. Natural convection with combined driving forces

    Science.gov (United States)

    Ostrach, S.

    1980-01-01

    The problem of free and natural convection with combined driving forces is considered in general and all possible configurations are identified. Dimensionless parameters are discussed in order to help categorize the various problems, and existing work is critically evaluated. Four distinct cases are considered for conventional convection and for the situation when the body force and the density gradient are parallel but opposed. Considerable emphasis is given to unstable convection in horizontal layers.

  16. Surgical and Prosthetic Rehabilitation of Combination Syndrome

    Directory of Open Access Journals (Sweden)

    Paolo Carlino

    2014-01-01

    Full Text Available The aim of this report is to analyze the clinical symptoms, ethologic factors, and prosthetic rehabilitation in a case of Combination Syndrome (CS. The treatment of CS can be conventional or surgical, with or without the bone reconstruction of maxilla. The correct prosthetic treatment helps this kind of patients to restore the physiologic occlusion plane to allow a correct masticatory and aesthetic function. Management of this kind of patients can be a challenge for a dental practitioner.

  17. Suction caissons subjected to monotonic combined loading

    OpenAIRE

    Penzes, P.; Jensen, M.R.; Zania, Varvara

    2016-01-01

    Suction caissons are being increasingly used as offshore foundation solutions in shallow and intermediate water depths. The convenient installation method through the application of suction has rendered this type of foundation as an attractive alternative to the more traditional monopile foundation for offshore wind turbines. The combined loading imposed typically to a suction caisson has led to the estimation of their bearing capacity by means of 3D failure envelopes. This study aims to anal...

  18. Screening for severe combined immunodeficiency in neonates

    OpenAIRE

    Kelly, Brian T; Tam, Jonathan S; Verbsky, James W; Routes, John M

    2013-01-01

    Brian T Kelly,1 Jonathan S Tam,1 James W Verbsky,1,2 John M Routes1,2 1Department of Pediatrics, 2Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI, USA Abstract: Severe combined immunodeficiency (SCID) is a rare disease that severely affects the cellular and humoral immune systems. Patients with SCID present with recurrent or severe infections and often with chronic diarrhea and failure to thrive. The disease is uniformly fatal, making early diag...

  19. On Coding Non-Contiguous Letter Combinations

    Directory of Open Access Journals (Sweden)

    Frédéric eDandurand

    2011-06-01

    Full Text Available Starting from the hypothesis that printed word identification initially involves the parallel mapping of visual features onto location-specific letter identities, we analyze the type of information that would be involved in optimally mapping this location-specific orthographic code onto a location-invariant lexical code. We assume that some intermediate level of coding exists between individual letters and whole words, and that this involves the representation of letter combinations. We then investigate the nature of this intermediate level of coding given the constraints of optimality. This intermediate level of coding is expected to compress data while retaining as much information as possible about word identity. Information conveyed by letters is a function of how much they constrain word identity and how visible they are. Optimization of this coding is a combination of minimizing resources (using the most compact representations and maximizing information. We show that in a large proportion of cases, non-contiguous letter sequences contain more information than contiguous sequences, while at the same time requiring less precise coding. Moreover, we found that the best predictor of human performance in orthographic priming experiments was within-word ranking of conditional probabilities, rather than average conditional probabilities. We conclude that from an optimality perspective, readers learn to select certain contiguous and non-contiguous letter combinations as information that provides the best cue to word identity.

  20. The 2004 ATLAS Combined Test Beam

    CERN Multimedia

    The ATLAS CTB Team, .

    2004-01-01

    In the year 2004, ATLAS has been involved in a huge combined test beam (CTB) effort in H8. A complete slice of the barrel detector and of the Muon End-cap has been tested, with the following clear goals: pre-commission the final elements and study the detector performance in a realistic combined data taking. Thanks to this experience, a lot of expertise in the operations has been acquired and much data (~ 4.6 TB of data, ~ 90 million events on castor) has been collected and is already under analysis. The CTB has been characterized by different phases with an incremental presence of sub-detectors modules and associated DAQ infrastructure, as well as incremental improvement of analysis tools for prompt data certification. The physics goals of the CTB have been defined in consultation with the physics coordinator, all the sub-detector representatives and the combined performance group representative. With all these indications, a detailed run plan day-by-day schedule was defined before the CTB start and was foll...

  1. Combining Symbolic Representations for Solving Timed Games

    Science.gov (United States)

    Ehlers, Rüdiger; Mattmüller, Robert; Peter, Hans-Jörg

    We present a general approach to combine symbolic state space representations for the discrete and continuous parts in the synthesis of winning strategies for timed reachability games. The combination is based on abstraction refinement where discrete symbolic techniques are used to produce a sequence of abstract timed game automata. After each refinement step, the resulting abstraction is used for computing an under- and an over-approximation of the timed winning states. The key idea is to identify large relevant and irrelevant parts of the precise weakest winning strategy already on coarse, and therefore simple, abstractions. If neither the existence nor nonexistence of a winning strategy can be established in the approximations, we use them to guide the refinement process. Based on a prototype that combines binary decision diagrams[7,9] and difference bound matrices[5], we experimentally evaluate the technique on standard benchmarks from timed controller synthesis. The results clearly demonstrate the potential of the new approach concerning running time and memory consumption compared to the classical on-the-fly algorithm implemented in Uppaal-Tiga [10,4].

  2. Rational Combinations of Targeted Agents in AML

    Directory of Open Access Journals (Sweden)

    Prithviraj Bose

    2015-04-01

    Full Text Available Despite modest improvements in survival over the last several decades, the treatment of AML continues to present a formidable challenge. Most patients are elderly, and these individuals, as well as those with secondary, therapy-related, or relapsed/refractory AML, are particularly difficult to treat, owing to both aggressive disease biology and the high toxicity of current chemotherapeutic regimens. It has become increasingly apparent in recent years that coordinated interruption of cooperative survival signaling pathways in malignant cells is necessary for optimal therapeutic results. The modest efficacy of monotherapy with both cytotoxic and targeted agents in AML testifies to this. As the complex biology of AML continues to be elucidated, many “synthetic lethal” strategies involving rational combinations of targeted agents have been developed. Unfortunately, relatively few of these have been tested clinically, although there is growing interest in this area. In this article, the preclinical and, where available, clinical data on some of the most promising rational combinations of targeted agents in AML are summarized. While new molecules should continue to be combined with conventional genotoxic drugs of proven efficacy, there is perhaps a need to rethink traditional philosophies of clinical trial development and regulatory approval with a focus on mechanism-based, synergistic strategies.

  3. Severe combined immunodeficiencies and related disorders.

    Science.gov (United States)

    Fischer, Alain; Notarangelo, Luigi D; Neven, Bénédicte; Cavazzana, Marina; Puck, Jennifer M

    2015-10-29

    Severe combined immunodeficiencies (SCIDs) comprise a group of rare, monogenic diseases that are characterized by an early onset and a profound block in the development of T lymphocytes. Given that adaptive immunity is abrogated, patients with SCID are prone to recurrent infections caused by both non-opportunistic and opportunistic pathogens, leading to early death unless immunity can be restored. Several molecular defects causing SCIDs have been identified, along with many other defects causing profound, albeit incomplete, T cell immunodeficiencies; the latter are referred to as atypical SCIDs or combined immunodeficiencies. The pathophysiology of many of these conditions has now been characterized. Early, accurate and precise diagnosis combined with the ongoing implementation of newborn screening have enabled major advances in the care of infants with SCID, including better outcomes of allogeneic haematopoietic stem cell transplantation. Gene therapy is also becoming an effective option. Further advances and a progressive extension of the indications for gene therapy can be expected in the future. The assessment of long-term outcomes of patients with SCID is now a major challenge, with a view to evaluating the quality and sustainability of immune restoration, the risks of sequelae and the ability to relieve the non-haematopoietic syndromic manifestations that accompany some of these conditions.

  4. Combined effects of radiation and trauma

    Science.gov (United States)

    Messerschmidt, Otfried

    Injuries, caused by both whole-body irradiation and wounds or burns, have been relatively little studied. Possibly because many investigators think that these injuries are just modified radiation-induced diseases for which the same treatment principles are valid. Other authors had the impression that, for instance, the radiation burn trauma is a new kind of disease which differs significantly from either radiation syndrome alone or from burn disease. There are many experimental data on animals which suggest that the pathology of combined injuries differs significantly from that of radiation-induced disease or of thermal or mechanical traumas. Wounds or burns which, in general, do not cause septicaemia could become entrance ports for bacteria when animals are exposed to whole-body irradiation. Thrombocytopenia is the reason for hemorrhages in wounds. The susceptibility to shock is increased considerably in combined injuries and the formation of callus in the bone fractures is significantly delayed. The healing of wounds and burns in the initial phase of the radiation syndrome does not always differ from healing in the non-irradiated organism. However, a few days or weeks later very serious wound infections and hemorrhages can occur. The additional injuries almost always worsen the development and prognosis of radiation-induced disease. The recommended treatment for combined injuries will differ in many respects from the treatment of wounds and burns or the radiation syndrome.

  5. Genetic compatibility determines endophyte-grass combinations.

    Directory of Open Access Journals (Sweden)

    Kari Saikkonen

    Full Text Available Even highly mutually beneficial microbial-plant interactions, such as mycorrhizal- and rhizobial-plant exchanges, involve selfishness, cheating and power-struggles between the partners, which depending on prevailing selective pressures, lead to a continuum of interactions from antagonistic to mutualistic. Using manipulated grass-endophyte combinations in a five year common garden experiment, we show that grass genotypes and genetic mismatches constrain genetic combinations between the vertically (via host seeds transmitted endophytes and the out-crossing host, thereby reducing infections in established grass populations. Infections were lost in both grass tillers and seedlings in F(1 and F(2 generations, respectively. Experimental plants were collected as seeds from two different environments, i.e., meadows and nearby riverbanks. Endophyte-related benefits to the host included an increased number of inflorescences, but only in meadow plants and not until the last growing season of the experiment. Our results illustrate the importance of genetic host specificity and trans-generational maternal effects on the genetic structure of a host population, which act as destabilizing forces in endophyte-grass symbioses. We propose that (1 genetic mismatches may act as a buffering mechanism against highly competitive endophyte-grass genotype combinations threatening the biodiversity of grassland communities and (2 these mismatches should be acknowledged, particularly in breeding programmes aimed at harnessing systemic and heritable endophytes to improve the agriculturally valuable characteristics of cultivars.

  6. Regulatory requirements for marketing fixed dose combinations

    Directory of Open Access Journals (Sweden)

    B G Jayasheel

    2010-01-01

    Full Text Available The development of fixed-dose combinations (FDCs is becoming increasingly important from a public health perspective. FDCs have advantages when there is an identifiable patient population for whom treatment with a particular combination of actives in a fixed ratio is safe and effective and when all of the actives contribute to the overall therapeutic effect. Such combinations of drugs are particularly useful in the management of chronic diseases. In addition, there can be real clinical benefits in the form of increased efficacy and/or a reduced incidence of adverse effects. Additional advantages of FDCs are potentially lower costs of manufacturing compared to the costs of producing separate products administered concurrently, simpler logistics of distribution and reduced development of resistance in the case of antimicrobials. Above all, FDC therapy reduces pill burden and improves medication compliance. Although, FDCs seem to be ideal under certain pre-defined circumstances, if a dosing adjustment is warranted, there may not be an FDC available in the most appropriate strength for the patient and if an adverse drug reaction occurs from using an FDC, it may be difficult to identify the active ingredient responsible for causing the reaction. Appendix VI of Schedule Y (Drugs & Cosmetics Rules 1945, India states the requirements for marketing approval of various types of FDCs. The same is further elaborated in this article to provide a detailed guidance including the clinical trial requirements. However, the heterogeneity of the therapeutic field makes it difficult to develop a standard guidance document.

  7. Proximal Row Carpectomy Combined with Wrist Hemiarthroplasty

    Science.gov (United States)

    Culp, Randall W.; Bachoura, Abdo; Gelman, Scott E.; Jacoby, Sidney M.

    2012-01-01

    Proximal row carpectomy (PRC) combined with distal radius hemiarthroplasty is a relatively novel procedure that rivals total wrist arthrodesis and offers a new surgical treatment option for select patients with painful, end-stage wrist disease. We present our early experience with this procedure. A retrospective chart review was conducted for nonrheumatoid patients diagnosed with wrist arthritis and subsequently treated with wrist hemiarthroplasty combined with PRC. The minimum follow-up duration was 12 months. Preoperative and postoperative flexion, extension, and grip strength were recorded. Postoperative radiographic findings were assessed. The Patient-Rated Wrist Evaluation (PRWE) questionnaire was administered to gauge postoperative pain and function. The records of 10 patients were reviewed. The mean age was 64 years and the mean postoperative follow-up duration was 19 months. Postoperative flexion, extension, and grip strength were all found to be less than the preoperative levels. The mean postoperative PRWE score for pain and function were 26 and 23, respectively. The complications were diverse and occurred at a relatively high rate. PRC combined with distal radius hemiarthroplasty is a novel procedure that offers a potential surgical option for the treatment of wrist arthritis in select patients. Our early experience has lead us to modify our technique with regard to the implant material, and at this stage, the surgical technique and the most appropriate implant may require further optimization. The level of evidence for this study is IV (therapeutic). PMID:23904978

  8. Unsupervised Retinal Vessel Segmentation Using Combined Filters

    Science.gov (United States)

    Oliveira, Wendeson S.; Teixeira, Joyce Vitor; Ren, Tsang Ing; Cavalcanti, George D. C.; Sijbers, Jan

    2016-01-01

    Image segmentation of retinal blood vessels is a process that can help to predict and diagnose cardiovascular related diseases, such as hypertension and diabetes, which are known to affect the retinal blood vessels’ appearance. This work proposes an unsupervised method for the segmentation of retinal vessels images using a combined matched filter, Frangi’s filter and Gabor Wavelet filter to enhance the images. The combination of these three filters in order to improve the segmentation is the main motivation of this work. We investigate two approaches to perform the filter combination: weighted mean and median ranking. Segmentation methods are tested after the vessel enhancement. Enhanced images with median ranking are segmented using a simple threshold criterion. Two segmentation procedures are applied when considering enhanced retinal images using the weighted mean approach. The first method is based on deformable models and the second uses fuzzy C-means for the image segmentation. The procedure is evaluated using two public image databases, Drive and Stare. The experimental results demonstrate that the proposed methods perform well for vessel segmentation in comparison with state-of-the-art methods. PMID:26919587

  9. Unsupervised Retinal Vessel Segmentation Using Combined Filters.

    Directory of Open Access Journals (Sweden)

    Wendeson S Oliveira

    Full Text Available Image segmentation of retinal blood vessels is a process that can help to predict and diagnose cardiovascular related diseases, such as hypertension and diabetes, which are known to affect the retinal blood vessels' appearance. This work proposes an unsupervised method for the segmentation of retinal vessels images using a combined matched filter, Frangi's filter and Gabor Wavelet filter to enhance the images. The combination of these three filters in order to improve the segmentation is the main motivation of this work. We investigate two approaches to perform the filter combination: weighted mean and median ranking. Segmentation methods are tested after the vessel enhancement. Enhanced images with median ranking are segmented using a simple threshold criterion. Two segmentation procedures are applied when considering enhanced retinal images using the weighted mean approach. The first method is based on deformable models and the second uses fuzzy C-means for the image segmentation. The procedure is evaluated using two public image databases, Drive and Stare. The experimental results demonstrate that the proposed methods perform well for vessel segmentation in comparison with state-of-the-art methods.

  10. Combining classifiers for robust PICO element detection

    Directory of Open Access Journals (Sweden)

    Grad Roland

    2010-05-01

    Full Text Available Abstract Background Formulating a clinical information need in terms of the four atomic parts which are Population/Problem, Intervention, Comparison and Outcome (known as PICO elements facilitates searching for a precise answer within a large medical citation database. However, using PICO defined items in the information retrieval process requires a search engine to be able to detect and index PICO elements in the collection in order for the system to retrieve relevant documents. Methods In this study, we tested multiple supervised classification algorithms and their combinations for detecting PICO elements within medical abstracts. Using the structural descriptors that are embedded in some medical abstracts, we have automatically gathered large training/testing data sets for each PICO element. Results Combining multiple classifiers using a weighted linear combination of their prediction scores achieves promising results with an f-measure score of 86.3% for P, 67% for I and 56.6% for O. Conclusions Our experiments on the identification of PICO elements showed that the task is very challenging. Nevertheless, the performance achieved by our identification method is competitive with previously published results and shows that this task can be achieved with a high accuracy for the P element but lower ones for I and O elements.

  11. COMO: a program for combined molecular replacement.

    Science.gov (United States)

    Jogl, G; Tao, X; Xu, Y; Tong, L

    2001-08-01

    The combined molecular-replacement protocol uses a limited six-dimensional search to solve a structure by the molecular-replacement method, with the sampling of the rotational degrees of freedom guided by the rotation function. This protocol therefore automatically combines the information on the rotational and translational parameters of the search model. The combined molecular-replacement protocol has been implemented in a new computer program, COMO. The calculation of the Patterson correlation translation function has been optimized to improve its speed performance. A packing check is implemented that automatically removes impossible solutions and thereby increases the signal in the calculation. A family of atomic models can be used as the search model; the program will automatically select the model that gives the best result. The command interface is well organized and requires the definition of only a few critical parameters by the user. In addition, a graphical user interface has been constructed for the program. The program has been used to solve several difficult molecular-replacement problems. A case is presented where the program automatically determined the orientation and position of five copies of a search model in a high-symmetry space group.

  12. Combined impact features for laser plasma generation

    International Nuclear Information System (INIS)

    Loktionov, E; Protasov, Yu; Telekh, V

    2017-01-01

    Laser-induced plasma has been considered for multiple applications by the moment, and its characteristics strongly depend on laser radiation parameters. Reaching demanded values for the latter might be rather costly, but, in certain cases, similar or even better results could be reached in case of additional impact (optical, electric, magnetic, corpuscular, mechanical etc.). Combined impact effects are mainly based on target properties or interaction mechanism change, and found to decrease plasma generation thresholds by orders of magnitude, improve energy efficiency significantly, and also broaden the range of plasma parameters. Application area, efficiency and optimal regimes for laser plasma generation at such combined impact have been considered. Analysis based on published data and own experiments was performed for both target material and induced plasma flows. Criterial parameters have been suggested to characterize both combined impact and response to it. The data on plasma generation thresholds, controlled parameters, working media supply systems and recovery rate of droplets are very important for technology setups, including those for material modification. (paper)

  13. Combined modality therapy in the elderly population.

    Science.gov (United States)

    Lin, Lilie L; Hahn, Stephen M

    2009-08-01

    The incidence of cancer among older patients continues to rise. The use of combined modality therapy has improved survival in a variety of malignancies, including rectal, head and neck, and lung cancer; however, the addition of chemotherapy increases substantially the toxicities of treatment. Elderly patients have generally been excluded from prospective clinical trials and as such, there is a lack of evidence-based data with regards to the most appropriate treatment. Age itself should not be used as a criterion for foregoing combined modality therapy in elderly patients. Due to the increased toxicity of therapy, patients must be carefully selected. Any medical intervention should account for life expectancy, performance status, tolerance to therapy, and presence of medical or social conditions that may impact therapy. We encourage a comprehensive geriatric assessment to evaluate functional status, comorbidities, mental status, psychological state, social support, nutritional status, polypharmacy, and geriatric conditions in order to improve a patient's overall functional status during the course of therapy. Fit elderly patients should be considered candidates for combined modality therapy, however, because they are potentially more vulnerable to therapy, careful attention should be paid to hydration and nutritional status with early intervention when necessary. Investigators should be encouraged to expand eligibility to include elderly patients on non age-related clinical trials. Additionally, therapy-related clinical trials directed at the elderly should be developed.

  14. Reports from the Combined Performance Working Groups

    CERN Multimedia

    S. Haywood

    The main goal of the Combined Performance Groups is to study the detector performance for physics, as well as to monitor the effect of changes to the detector layout and the evolution of the software. The groups combine the expertise available in several different subdetectors. In addition, they are responsible for developing combined reconstruction algorithms and are involved in the calibration of energy scales and optimising resolutions. For the Workshop, the four groups made a real effort to compare the reconstruction in Athena (the "New" C++ software framework) and Atrecon (the "Old" software used for the TDR studies). b-tagging Working Group: Over the last few months, the description of the Inner Detector in the simulation has become more realistic, following the evolution of the detector design. This has caused the amount of material in the simulation to increase and the Pixel B-layer has been moved to a larger radius to allow for a wider beam-pipe. Nevertheless, the good performance of the b-tagging (...

  15. Fixed Dose Combination for TB treatment

    Directory of Open Access Journals (Sweden)

    Tjandra Y. Aditama

    2003-06-01

    Full Text Available According to the World Health Organization, a third of the world’s population is infected with tuberculosis. The disease is responsible for nearly 2 million deaths each year and over 8 million were developing active diseases. Moreover, according to WHO (2000, tuberculosis deaths are estimated to increase to 35 million between 2000-2020. The majority of tuberculosis patients worldwide are still treated with single drugs, or with 2-drug fixed-dose combinations (FDCs. To improve tuberculosis treatment, 2- and 3-drug FDCs were recommended by the World Health Organization (WHO as part of the DOTS strategy. Since 1999 a 4-drug FDC was included on the WHO Model List of Essential Drugs. Today, FDCs are important tools to further improve the quality of care for people with TB, and accelerate DOTS expansion to reach the global TB control targets. Fixed dose combination TB drugs could simplifies both treatment and management of drug supply, and may prevent the emergence of drug resistance .Prevention of drug resistance is just one of the potential benefits of the use of FDCs. FDCs simplify administration of drugs by reducing the number of pills a patient takes each day and decreasing the risk of incorrect prescriptions. Most tuberculosis patients need only take 3–4 FDCs tablets per day during the intensive phase of treatment, instead of the 15–16 tablets per day that is common with single-drug formulations It is much simpler to explain to patients that they need to take four tablets of the same type and colour, rather than a mixture of tablets of different shapes, colours and sizes. Also, the chance of taking an incomplete combination of drugs is eliminated, since the four essential drugs are combined into one tablet. FDCs are also simpler for care-givers as they minimize the risk of confusion. Finally, drug procurement, in all its components (stock management, shipping, distribution, is simplified by FDCs. Adverse reactions to drugs are not more

  16. Combining disparate data for decision making

    Science.gov (United States)

    Gettings, M. E.

    2010-12-01

    Combining information of disparate types from multiple data or model sources is a fundamental task in decision making theory. Procedures for combining and utilizing quantitative data with uncertainties are well-developed in several approaches, but methods for including qualitative and semi-quantitative data are much less so. Possibility theory offers an approach to treating all three data types in an objective and repeatable way. In decision making, biases are frequently present in several forms, including those arising from data quality, data spatial and temporal distribution, and the analyst's knowledge and beliefs as to which data or models are most important. The latter bias is particularly evident in the case of qualitative data and there are numerous examples of analysts feeling that a qualitative dataset is more relevant than a quantified one. Possibility theory and fuzzy logic now provide fairly general rules for quantifying qualitative and semi-quantitative data in ways that are repeatable and minimally biased. Once a set of quantified data and/or model layers is obtained, there are several methods of combining them to obtain insight useful in decision making. These include: various combinations of layers using formal fuzzy logic (for example, layer A and (layer B or layer C) but not layer D); connecting the layers with varying influence links in a Fuzzy Cognitive Map; and using the set of layers for the universe of discourse for agent based model simulations. One example of logical combinations that have proven useful is the definition of possible habitat for valley fever fungus (Coccidioides sp.) using variables such as soil type, altitude, aspect, moisture and temperature. A second example is the delineation of the lithology and possible mineralization of several areas beneath basin fill in southern Arizona. A Fuzzy Cognitive Map example is the impacts of development and operation of a hypothetical mine in an area adjacent to a city. In this model

  17. Spectral beam combining of diode lasers with high efficiency

    DEFF Research Database (Denmark)

    Müller, André; Vijayakumar, Deepak; Jensen, Ole Bjarlin

    2012-01-01

    Based on spectral beam combining we obtain 16 W of output power, combining two 1063 nm DBR-tapered diode lasers. The spectral separation within the combined beam can be used for subsequent sum-frequency generation.......Based on spectral beam combining we obtain 16 W of output power, combining two 1063 nm DBR-tapered diode lasers. The spectral separation within the combined beam can be used for subsequent sum-frequency generation....

  18. IMPLICATION OF THE FIXED COMBINATIONS IN THE HYPERTENSION TREATMENT

    Directory of Open Access Journals (Sweden)

    Z. D. Kobalava

    2010-01-01

    Full Text Available The role of fixed combinations in the hypertension (HT treatment is discussed. Theoretical and practical aspects of combination therapy, principles of rational combination therapy are present. Current guidelines on the use of fixed dose combinations, including start antihypertensive therapy are analyzed. Classification of combinations, advantages and limitations of some of them implementation are also presented. Significance of beta-blocker bisoprolol and thiazide diuretic hydrochlorothiazide fixed combination (Lodoz is shown in HT treatment.

  19. [First fixed dose combination perindopril arginine-indapamide-amlodipine: new approach in combination therapy in hypertension].

    Science.gov (United States)

    Widimský, Jiří

    2014-09-01

    Use of fixed combination of antihypertensive drugs clearly improves compliance to the pharmacological therapy, control of hypertension and prognosis. Based on the current guidelines triple antihypertensive therapy with RAS-blocker, calcium channel blocker (CCB) and diuretic represents the standard and best option. The article introduces first and innovative fixed triple combination of perindopril arginine + indapamide + amlodipine (Triplixam®). This type of therapy is suitable for patients already treated with free combinations of three antihypertensive drugs or in those hypertensives with uncontrolled hypertension on two antihypertensive molecules (approx. 60% of all hypertensive population). Fixed combination of perindopril arginine + indapamid + amlodipin is indicated also in severe hypertension (approx. 30% of pts). Large clinical data from various morbidity-mortality studies related to each of these substances are discussed as well as basic pharmacological characteristics. Based on the results from ADVANCE-CCB study combination of perindopril arginine + indapamide + CCB decreases total mortality in hypertension by 28%. Another discussed study-PIANIST confirmed significant antihypertensive effect of Triplixam® on large sample of patients with various stages of hypertension. Triplixam® in addition to that has very good tolerance with low side effects profile, flexibility of the dosages and large body of evidence of positive impact on prognosis of hypertensive patients. Use of Triplixam® may improve control of hypertension in the Czech Republic.Key words: amlodipine - fixed combination - hypertension - indapamide - perindopril arginine - therapy.

  20. Combination therapy accelerates diabetic wound closure.

    Directory of Open Access Journals (Sweden)

    Robert J Allen

    Full Text Available Non-healing foot ulcers are the most common cause of non-traumatic amputation and hospitalization amongst diabetics in the developed world. Impaired wound neovascularization perpetuates a cycle of dysfunctional tissue repair and regeneration. Evidence implicates defective mobilization of marrow-derived progenitor cells (PCs as a fundamental cause of impaired diabetic neovascularization. Currently, there are no FDA-approved therapies to address this defect. Here we report an endogenous PC strategy to improve diabetic wound neovascularization and closure through a combination therapy of AMD3100, which mobilizes marrow-derived PCs by competitively binding to the cell surface CXCR4 receptor, and PDGF-BB, which is a protein known to enhance cell growth, progenitor cell migration and angiogenesis.Wounded mice were assigned to 1 of 5 experimental arms (n = 8/arm: saline treated wild-type, saline treated diabetic, AMD3100 treated diabetic, PDGF-BB treated diabetic, and AMD3100/PDGF-BB treated diabetic. Circulating PC number and wound vascularity were analyzed for each group (n = 8/group. Cellular function was assessed in the presence of AMD3100. Using a validated preclinical model of type II diabetic wound healing, we show that AMD3100 therapy (10 mg/kg; i.p. daily alone can rescue diabetes-specific defects in PC mobilization, but cannot restore normal wound neovascularization. Through further investigation, we demonstrate an acquired trafficking-defect within AMD3100-treated diabetic PCs that can be rescued by PDGF-BB (2 μg; topical supplementation within the wound environment. Finally, we determine that combination therapy restores diabetic wound neovascularization and accelerates time to wound closure by 40%.Combination AMD3100 and PDGF-BB therapy synergistically improves BM PC mobilization and trafficking, resulting in significantly improved diabetic wound closure and neovascularization. The success of this endogenous, cell-based strategy to

  1. Modeling of a combined cycle power plant

    International Nuclear Information System (INIS)

    Faridah Mohamad Idris

    2001-01-01

    The combined cycle power plant is a non-linear, closed loop system, which consists of high-pressure (HP) superheater, HP evaporator, HP economizer, low-pressure (LP) evaporator, HP drum, HP deaerator, condenser, HP and LP steam turbine and gas turbine. The two types of turbines in the plant for example the gas turbine and the HP and LP steam turbines operate concurrently to generate power to the plant. The exhaust gas which originate from the combustion chamber drives the gas turbine, after which it flows into the heat recovery steam generator (HRSG) to generate superheated steam to be used in driving the HP and LP steam turbines. In this thesis, the combined cycle power plant is modeled at component level using the physical method. Assuming that there is delay in transport, except for the gas turbine system, the mass and heat balances are applied on the components of the plant to derive the governing equations of the components. These time dependent equations, which are of first order differential types, are then solved for the mass and enthalpy of the components. The solutions were simulated using Matlab Simulink using measured plant data. Where necessary there is no plant data available, approximated data were used. The generalized regression neural networks are also used to generate extra sets of simulation data for the HRSG system. Comparisons of the simulation results with its corresponding plant data showed good agreements between the two and indicated that the models developed for the components could be used to represent the combined cycle power plant under study. (author)

  2. VLBI TRF Combination Using GNSS Software

    Directory of Open Access Journals (Sweden)

    Younghee Kwak

    2013-12-01

    Full Text Available Space geodetic techniques can be used to obtain precise shape and rotation information of the Earth. To achieve this, the representative combination solution of each space geodetic technique has to be produced, and then those solutions need to be combined. In this study, the representative combination solution of very long baseline interferometry (VLBI, which is one of the space geodetic techniques, was produced, and the variations in the position coordinate of each station during 7 years were analyzed. Products from five analysis centers of the International VLBI Service for Geodesy and Astrometry (IVS were used as the input data, and Bernese 5.0, which is the global navigation satellite system (GNSS data processing software, was used. The analysis of the coordinate time series for the 43 VLBI stations indicated that the latitude component error was about 15.6 mm, the longitude component error was about 37.7 mm, and the height component error was about 30.9 mm, with respect to the reference frame, International Terrestrial Reference Frame 2008 (ITRF2008. The velocity vector of the 42 stations excluding the YEBES station showed a magnitude difference of 7.3 mm/yr (30.2% and a direction difference of 13.8° (3.8%, with respect to ITRF2008. Among these, the 10 stations in Europe showed a magnitude difference of 7.8 mm/yr (30.3% and a direction difference of 3.7° (1.0%, while the 14 stations in North America showed a magnitude difference of 2.7 mm/yr (15.8% and a direction difference of 10.3° (2.9%.

  3. The combination of electrospray and flow focusing

    Science.gov (United States)

    Gañán-Calvo, Alfonso M.; López-Herrera, José M.; Riesco-Chueca, Pascual

    2006-11-01

    An ultra-fine liquid atomization procedure combining the advantages of electrospray and flow focusing is presented. Both techniques are known to produce strikingly small and steady liquid micro-jets issuing from menisci held by capillary forces. Such menisci take the form of a cusp-like drop attached to the feeding tube (flow focusing: FF) or a Taylor cone (electrospray: ES). The issuing micro-jets are forced or ‘sucked’ from the parent meniscus either by pressure or electrohydrodynamic forces. Subsequent capillary breakup of the jet leads to fine sprays of remarkable quality. Here we describe the joint effect of pressurization and electrification in a flow focusing device, and the subsequent coupling of both ES and FF phenomena. For any given liquid and flow rate, the combined procedure gives rise to significantly smaller droplet sizes than observed in any of the source techniques. The co-flowing gas stream removes space charges; in addition, the perforated plate facing the feed tube provides an electric barrier, shielding the jet-meniscus or ‘production’ area from the spray or ‘product’ area. As a result, space charges and electrified droplets are removed from the production area, thus avoiding the ambient electric saturation which becomes a limiting factor in ES-spraying: a significantly enhanced spraying stability ensues, with a much wider operation range than FF or ES. Other unexpected outcomes from the combination are also shown. A theoretical model is developed to predict the emitted droplet size: a first integral of the momentum equation yielding a generalized Bernoulli equation, and an explicit approximation for the jet diameter and droplet size, accurate within a broad parametrical band.

  4. Biopiles and biofilters combined for soil cleanup

    International Nuclear Information System (INIS)

    Lei, J.; Sansregret, J.L.; Cyr, B.

    1994-01-01

    Bioremediation of hydrocarbon-contaminated soils can be completed using a combination of biopile and biofiltration technologies. Target contaminants, such as gasoline, jet fuel, diesel fuel and other petroleum-derived products are removed from the soil by biodegradation and volatilization in the biopile. Air emissions from the biopile containing volatile hydrocarbons are treated subsequently in a biofilter, where the pollutants are degraded and mineralized by heterotrophic aerobic microorganisms. In the biopile process, contaminated soil is excavated and stockpiled in a treatment area. Remediation of the soil relies on microbial degradation and volatilization of hydrocarbons under controlled treatment conditions

  5. Strongyloides Hyperinfection Syndrome Combined with Cytomegalovirus Infection

    Directory of Open Access Journals (Sweden)

    Fatehi Elnour Elzein

    2016-01-01

    Full Text Available The mortality in Strongyloides hyperinfection syndrome (SHS is alarmingly high. This is particularly common in bone marrow, renal, and other solid organ transplant (SOT patients, where figures may reach up to 50–85%. Immunosuppressives, principally corticosteroids, are the primary triggering factor. In general, the clinical features of Strongyloides stercoralis hyperinfection are nonspecific; therefore, a high index of suspicion is required for early diagnosis and starting appropriate therapy. Although recurrent Gram-negative sepsis and meningitis have been previously reported, the combination of both cytomegalovirus (CMV and strongyloidiasis had rarely been associated. We here describe a patient who survived SHS with recurrent Escherichia coli (E. coli urosepsis and CMV infection.

  6. Combination of interval set and soft set

    Directory of Open Access Journals (Sweden)

    Keyun Qin

    2013-04-01

    Full Text Available Soft set theory and interval set theory are all mathematical tools for dealing with uncertainties. This paper is devoted to the discussion of soft interval set and its application. The notion of soft interval sets is introduced by combining soft set and interval set. Several operations on soft interval sets are presented in a manner parallel to that used in defining operations on soft sets and the lattice structures of soft interval sets are established. In addition, a soft interval set based decision making problem is analyzed.

  7. Combined constraints on holographic bosonic technicolor

    International Nuclear Information System (INIS)

    Carone, Christopher D.; Primulando, Reinard

    2010-01-01

    We consider a model of strong electroweak symmetry breaking in which the expectation value of an additional, possibly composite, scalar field is responsible for the generation of fermion masses. The dynamics of the strongly coupled sector is defined and studied via its holographic dual, and does not correspond to a simple, scaled-up version of QCD. We consider the bounds from perturbative unitarity, the S parameter, and the mass of the Higgs-like scalar. We show that the combination of these constraints leaves a relatively limited region of parameter space viable, and suggests the qualitative features of the model that might be probed at the LHC.

  8. Combination antifungal therapy for cryptococcal meningitis.

    Science.gov (United States)

    Day, Jeremy N; Chau, Tran T H; Wolbers, Marcel; Mai, Pham P; Dung, Nguyen T; Mai, Nguyen H; Phu, Nguyen H; Nghia, Ho D; Phong, Nguyen D; Thai, Cao Q; Thai, Le H; Chuong, Ly V; Sinh, Dinh X; Duong, Van A; Hoang, Thu N; Diep, Pham T; Campbell, James I; Sieu, Tran P M; Baker, Stephen G; Chau, Nguyen V V; Hien, Tran T; Lalloo, David G; Farrar, Jeremy J

    2013-04-04

    Combination antifungal therapy (amphotericin B deoxycholate and flucytosine) is the recommended treatment for cryptococcal meningitis but has not been shown to reduce mortality, as compared with amphotericin B alone. We performed a randomized, controlled trial to determine whether combining flucytosine or high-dose fluconazole with high-dose amphotericin B improved survival at 14 and 70 days. We conducted a randomized, three-group, open-label trial of induction therapy for cryptococcal meningitis in patients with human immunodeficiency virus infection. All patients received amphotericin B at a dose of 1 mg per kilogram of body weight per day; patients in group 1 were treated for 4 weeks, and those in groups 2 and 3 for 2 weeks. Patients in group 2 concurrently received flucytosine at a dose of 100 mg per kilogram per day for 2 weeks, and those in group 3 concurrently received fluconazole at a dose of 400 mg twice daily for 2 weeks. A total of 299 patients were enrolled. Fewer deaths occurred by days 14 and 70 among patients receiving amphotericin B and flucytosine than among those receiving amphotericin B alone (15 vs. 25 deaths by day 14; hazard ratio, 0.57; 95% confidence interval [CI], 0.30 to 1.08; unadjusted P=0.08; and 30 vs. 44 deaths by day 70; hazard ratio, 0.61; 95% CI, 0.39 to 0.97; unadjusted P=0.04). Combination therapy with fluconazole had no significant effect on survival, as compared with monotherapy (hazard ratio for death by 14 days, 0.78; 95% CI, 0.44 to 1.41; P=0.42; hazard ratio for death by 70 days, 0.71; 95% CI, 0.45 to 1.11; P=0.13). Amphotericin B plus flucytosine was associated with significantly increased rates of yeast clearance from cerebrospinal fluid (-0.42 log10 colony-forming units [CFU] per milliliter per day vs. -0.31 and -0.32 log10 CFU per milliliter per day in groups 1 and 3, respectively; P<0.001 for both comparisons). Rates of adverse events were similar in all groups, although neutropenia was more frequent in patients

  9. Radiotherapy versus combined modality in early stages

    DEFF Research Database (Denmark)

    Specht, L; Carde, P; Mauch, P

    1992-01-01

    In early stage Hodgkin's disease the optimal choice of treatment for the individual patient is still an unresolved issue. So far, twenty-two randomized trials of radiotherapy alone versus radiotherapy plus combination chemotherapy have been carried out worldwide. The preliminary results of a global...... be reduced, and that the stress of experiencing a relapse is avoided in many patients. The major argument against the use of chemotherapy up front is: that by careful staging and selection of patients and by careful radiotherapy techniques the number of patients exposed to potentially toxic chemotherapy may...

  10. Combination of behavioural and cognitive techniques

    Directory of Open Access Journals (Sweden)

    Leonida Rotvejn Pajič

    2001-03-01

    Full Text Available The cognitive - behavioral approach in the treatment of behavioral disorders, emotional disorders and learning difficulties is not limited to a single theoretical principle or technique, but integrates different techniques. The variants techniques are derived from theoretical and empirical findings in different domains of developmental psychology (self-control, social cognition, memory, metacognitive and attritional processes. The aim of the article is to present some basic cognitive and behavioral techniques that are individually adapted during therapy and mutually complete each other. A practical case of combining techniques is presented.

  11. Combining accounting approaches to practice valuation.

    Science.gov (United States)

    Schwartzben, D; Finkler, S A

    1998-06-01

    Healthcare organizations that wish to acquire physician or ambulatory care practices can choose from a variety of practice valuation approaches. Basic accounting methods assess the value of a physician practice on the basis of a historical, balance-sheet description of tangible assets. Yet these methods alone are inadequate to determine the true financial value of a practice. By using a combination of accounting approaches to practice valuation that consider factors such as fair market value, opportunity cost, and discounted cash flow over a defined time period, organizations can more accurately assess a practice's actual value.

  12. A Combined Preconditioning Strategy for Nonsymmetric Systems

    Energy Technology Data Exchange (ETDEWEB)

    de Dios, B. Ayuso [Univ. of Bologna (Italy). Dept. of Mathematics; King Abdullah Univ. of Science and Technology, Thuwal (Saudi Arabia); Barker, A. T. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Vassilevski, P. S. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2014-11-04

    Here, we present and analyze a class of nonsymmetric preconditioners within a normal (weighted least-squares) matrix form for use in GMRES to solve nonsymmetric matrix problems that typically arise in finite element discretizations. An example of the additive Schwarz method applied to nonsymmetric but definite matrices is presented for which the abstract assumptions are verified. Variable preconditioner, which combines the original nonsymmetric one and a weighted least-squares version of it, and it is shown to be convergent and provides a viable strategy for using nonsymmetric preconditioners in practice. Numerical results are included to assess the theory and the performance of the proposed preconditioners.

  13. Chondromyxoid bone fibroma in combination with angiolipoma?

    International Nuclear Information System (INIS)

    Matejka, J.; Krajcovic, L.

    1987-01-01

    A case is demonstrated combined chondromyxoid bone fibroma with angiolipoma with an unusual angiographic picture of this benign bone lesion which expresses signs of malignancy and does not correspond to the clinical course of the disease nor does it correspond to histopathological diagnosis. The authors also show that despite the characteristic X-ray picture of this lesion which generally indicates benign character of the process, it is necessary to differentiate it from other bening processes in which enchondromas should be considered first followed by non-ossifying fibromas, aneurysmatic bone cysts, solitary primary bone cysts, giant-cellular bone tumors, bening osteoblastomas and fibrous dysplasias. 7 figs., 30 refs

  14. Reorientation in combined stress induced martensite?

    International Nuclear Information System (INIS)

    Sittner, P.; Tokuda, M.

    1995-01-01

    The thermoelastic martensitic transformation induced by independent external forces has been investigated in combined tension-torsion experiments with Cu-Al-Zn-Mn SMA hollow bar polycrystals. When the nonproportional change of the applied stress (reloading) occurs at low volume fraction of stress induced martensite phase, the shape of the experimental transformation path suggests, that the forward or reverse stress induced martensitic transformations take place, depending whether the mechanical energy is being supplied or released. At higher volume fraction of martensite, the deformation behavior upon reloading becomes more complex, suggesting a possible role of martensite to martensite transformations or reorientation processes. (orig.)

  15. Anticancer Efficacy of Polyphenols and Their Combinations

    Directory of Open Access Journals (Sweden)

    Aleksandra Niedzwiecki

    2016-09-01

    Full Text Available Polyphenols, found abundantly in plants, display many anticarcinogenic properties including their inhibitory effects on cancer cell proliferation, tumor growth, angiogenesis, metastasis, and inflammation as well as inducing apoptosis. In addition, they can modulate immune system response and protect normal cells against free radicals damage. Most investigations on anticancer mechanisms of polyphenols were conducted with individual compounds. However, several studies, including ours, have indicated that anti-cancer efficacy and scope of action can be further enhanced by combining them synergistically with chemically similar or different compounds. While most studies investigated the anti-cancer effects of combinations of two or three compounds, we used more comprehensive mixtures of specific polyphenols and mixtures of polyphenols with vitamins, amino acids and other micronutrients. The mixture containing quercetin, curcumin, green tea, cruciferex, and resveratrol (PB demonstrated significant inhibition of the growth of Fanconi anemia head and neck squamous cell carcinoma and dose-dependent inhibition of cell proliferation, matrix metalloproteinase (MMP-2 and -9 secretion, cell migration and invasion through Matrigel. PB was found effective in inhibition of fibrosarcoma HT-1080 and melanoma A2058 cell proliferation, MMP-2 and -9 expression, invasion through Matrigel and inducing apoptosis, important parameters for cancer prevention. A combination of polyphenols (quercetin and green tea extract with vitamin C, amino acids and other micronutrients (EPQ demonstrated significant suppression of ovarian cancer ES-2 xenograft tumor growth and suppression of ovarian tumor growth and lung metastasis from IP injection of ovarian cancer A-2780 cells. The EPQ mixture without quercetin (NM also has shown potent anticancer activity in vivo and in vitro in a few dozen cancer cell lines by inhibiting tumor growth and metastasis, MMP-2 and -9 secretion, invasion

  16. A Combined Preconditioning Strategy for Nonsymmetric Systems

    KAUST Repository

    Ayuso Dios, Blanca

    2014-01-01

    We present and analyze a class of nonsymmetric preconditioners within a normal (weighted least-squares) matrix form for use in GMRES to solve nonsymmetric matrix problems that typically arise in finite element discretizations. An example of the additive Schwarz method applied to nonsymmetric but definite matrices is presented for which the abstract assumptions are verified. A variable preconditioner, combining the original nonsymmetric one and a weighted least-squares version of it, is shown to be convergent and provides a viable strategy for using nonsymmetric preconditioners in practice. Numerical results are included to assess the theory and the performance of the proposed preconditioners.

  17. Combining writing block treatments: theory and research.

    Science.gov (United States)

    Boice, R

    1992-03-01

    Four traditional formats of treatment for writing blocks (automaticity, regimen, self-control, and social skills training) proved insufficient to maintain unblocking in professorial writers for periods of an academic year. A combined application of the four historically prominent interventions was clearly more effective in terms of stable productivity, manuscripts finished and submitted, and manuscripts accepted for publication. Because writing blocks are too often conceptualized and treated by way of lore, a theory of blocking is proposed that clarifies the fundamental steps in effecting lasting unblocking.

  18. How Not to Combine RC4 States

    DEFF Research Database (Denmark)

    Banik, Subhadeep; Jha, Sonu

    2015-01-01

    Over the past few years, an attractive design paradigm has emerged, that aims to produce new stream cipher designs, by combining one or more independently produced RC4 states. The ciphers so produced turn out to be faster than RC4 on any software platform, mainly because the average number of int...... by Zhang et. al.) and Quad-RC4/m-RC4 (proposed by Maitra et. al.). We will propose distinguishing attacks against all these ciphers, and look at certain design flaws that made these ciphers vulnerable....

  19. High performance integrated solar combined cycles with minimum modifications to the combined cycle power plant design

    International Nuclear Information System (INIS)

    Manente, Giovanni

    2016-01-01

    Highlights: • Off-design model of a 390 MW e three pressure combined cycle developed and validated. • The off-design model is used to evaluate different hybridization schemes with solar. • Power boosting and fuel saving with different design modifications are considered. • Maximum solar share of total electricity is only 1% with the existing equipment. • The maximum incremental solar radiation-to-electrical efficiency approaches 29%. - Abstract: The integration of solar energy into natural gas combined cycles has been successfully demonstrated in several integrated solar combined cycles since the beginning of this decade in many countries. There are many motivations that drive investments on integrated solar combined cycles which are primarily the repowering of existing power plants, the compliance with more severe environmental laws on emissions and the mitigation of risks associated with large solar projects. Integrated solar combined cycles are usually developed as brownfield facilities by retrofitting existing natural gas combined cycles and keeping the existing equipment to minimize costs. In this work a detailed off-design model of a 390 MW e three pressure level natural gas combined cycle is built to evaluate different integration schemes of solar energy which either keep the equipment of the combined cycle unchanged or include new equipment (steam turbine, heat recovery steam generator). Both power boosting and fuel saving operation strategies are analyzed in the search for the highest annual efficiency and solar share. Results show that the maximum incremental power output from solar at design solar irradiance is limited to 19 MW e without modifications to the existing equipment. Higher values are attainable only including a larger steam turbine. High solar radiation-to-electrical efficiencies in the range 24–29% can be achieved in the integrated solar combined cycle depending on solar share and extension of tube banks in the heat recovery

  20. Doing Your Own Time: Peer Integration, Aggression and Mental Health in Dutch Male Detainment Facilities

    Science.gov (United States)

    Kreager, Derek A.; Palmen, Hanneke; Dirkzwager, Anja J.E.; Nieuwbeerta, Paul

    2016-01-01

    Background Prior research demonstrates a strong positive association between social integration (e.g., strong social ties) and individual health. However, researchers also emphasize that this correlation may vary by context and potentially reverse direction under certain conditions. In this study, we draw on competing criminological theories of peer relations to examine if social integration, measured by trust in peers, is positively or negatively associated with violence and mental health of men detained in pre-trial confinement facilities. Methods We test our hypotheses with peer network and health data from 502 Dutch male pre-trial detainees. Results Results suggest that peer trust has no direct association with reported rates of peer aggression while detained and low peer trust is generally protective for mental health. Conclusions Our study thus adds to a small body of literature finding that social integration within certain correctional settings may not operate in the same way that it does in the general population and may actually contribute to adverse mental health outcomes. PMID:26794247

  1. The Battle Behind the Wire: U. S. Prisoner and Detainee Operations from World War II to Iraq

    Science.gov (United States)

    2011-01-01

    among prisoners. The reeducation program had broader goals, albeit contested. Some, arguing that “ global warfare requires global thinking,” wanted...8 Reeducation Programs...quences for U.S. military and diplomatic efforts. The Abu Ghraib scan- dal put the United States in a defensive posture , causing the focus of its

  2. Factor Structure of the Hare Psychopathy Checklist: Youth Version in German Female and Male Detainees and Community Adolescents

    Science.gov (United States)

    Sevecke, Kathrin; Pukrop, Ralf; Kosson, David S.; Krischer, Maya K.

    2009-01-01

    Substantial evidence exists for 3- and 4-factor models of psychopathy underlying patterns of covariation among the items of the Psychopathy Checklist-Revised (PCL-R) in diverse adult samples. Although initial studies conducted with the Psychopathy Checklist: Youth Version (PCL:YV) indicated reasonable fit for these models in incarcerated male…

  3. CTC Sentinel. Volume 1, Issue 12, November 2008. The Dilemma of the Yemeni Detainees at Guantanamo Bay

    Science.gov (United States)

    2008-11-01

    barbed wire, earthen barriers and a wall of Humvees. At one point they breached the post and fighting was done face to face before the insurgents were...in retaliation for the capture of a senior Egyptian jihadist spokesman, and the killing of an Egyptian trade attaché in Geneva for his suspected...for Jemmah Islamiyah’s Recruitment,” in Rohaiza Ahmad Asi, Fighting Terrorism: Preventing the Radicalisation of Youth in a Secular and Globalised

  4. Irradiation in combined treatments and food safety

    International Nuclear Information System (INIS)

    Lacroix Monique; Dussault Dominic; Turgis Melanie; Salmieri Stephane; Perlette Takala; Vu Dang Khanh; Ayari Samia

    2013-01-01

    Irradiation combined with other processes can contribute to insuring food safety to consumers and controlling severe losses during transportation and commercialisation. We have demonstrated that using in synergy with other treatments; a lower dose could be used to eliminate pathogenic bacteria and permit a better protection of the sensorial quality and to prolong the shelf life of foods. Results indicated that some bacteria are more sensitive to irradiation under modified atmosphere (MAP) and the presence of active compound can increase the bacterial radiosensitivity by more than 4 times under air and by more than 10 times under MAP. Mild heat treatment or addition of natural antimicrobial compounds before irradiation treatment has also permitted an increase of Bacillus cereus radiosensitization. An increase of the bacterial radiosensitization of 1.5 and 1.56 was respectively observed. The effectiveness of the use of edible coating containing natural antimicrobial compounds, modified atmosphere packaging (MAP) or mild treatment before irradiation treatment was demonstrated in order to inactivate Listeria monocytogenes, Salmonella typhimurium, Escherichia coli and Bacillus cereus growth or B. cereus spore germination, to increase the bacterial sensitivity to irradiation, to reduce the water loss and to extend the shelf life of the food when stored at 4 deg C. Also, the use of edible coating previously crosslinked by irradiation have permitted a better control of the active compounds release. Studies of combined treatments were used in ready to eat vegetables, fruits and meat products. (author)

  5. Combining Search Engines for Comparative Proteomics

    Science.gov (United States)

    Tabb, David

    2012-01-01

    Many proteomics laboratories have found spectral counting to be an ideal way to recognize biomarkers that differentiate cohorts of samples. This approach assumes that proteins that differ in quantity between samples will generate different numbers of identifiable tandem mass spectra. Increasingly, researchers are employing multiple search engines to maximize the identifications generated from data collections. This talk evaluates four strategies to combine information from multiple search engines in comparative proteomics. The “Count Sum” model pools the spectra across search engines. The “Vote Counting” model combines the judgments from each search engine by protein. Two other models employ parametric and non-parametric analyses of protein-specific p-values from different search engines. We evaluated the four strategies in two different data sets. The ABRF iPRG 2009 study generated five LC-MS/MS analyses of “red” E. coli and five analyses of “yellow” E. coli. NCI CPTAC Study 6 generated five concentrations of Sigma UPS1 spiked into a yeast background. All data were identified with X!Tandem, Sequest, MyriMatch, and TagRecon. For both sample types, “Vote Counting” appeared to manage the diverse identification sets most effectively, yielding heightened discrimination as more search engines were added.

  6. ACCOUNTING FOR CONTINGENT CONSIDERATIONS IN BUSINESS COMBINATIONS

    Directory of Open Access Journals (Sweden)

    Gurgen KALASHYAN

    2017-07-01

    Full Text Available According to IFRS 3 Business Combinations contingent considerations must be included in the total consideration given for the acquired entity along with cash, other assets, ordinary or preference equity instruments, options, warrants. The contingent consideration is the determined amount which acquiring entity has to pay to acquired entity provided, that certain conditions will be fulfilled in the future. In case the provisions are not satisfied, we will get the situation when the amount of contingent consideration has been included in the total consideration given in the business combination, but in fact, the acquirer has not paid that amount. In its turn, the acquired entity will recognize the contingent consideration as a financial asset according to IFRS 9 Financial Instruments. In that case, it would be appropriately to recognize the contingent consideration as a contingent asset applying IAS 37. In the Article the author will explore the challenges of contingent consideration accounting and suggest the ways of solving the above mentioned problems.

  7. Combining rhinoplasty with septal perforation repair.

    Science.gov (United States)

    Foda, Hossam M T; Magdy, Emad A

    2006-11-01

    A combined septal perforation repair and rhinoplasty was performed in 80 patients presenting with septal perforations (size 1 to 5 cm) and external nasal deformities. The external rhinoplasty approach was used for all cases and the perforation was repaired using bilateral intranasal mucosal advancement flaps with a connective tissue interposition graft in between. Complete closure of the perforation was achieved in 90% of perforations of size up to 3.5 cm and in only 70% of perforations that were larger than 3.5 cm. Cosmetically, 95% were very satisfied with their aesthetic result. The external rhinoplasty approach proved to be very helpful in the process of septal perforation repair especially in large and posteriorly located perforations and in cases where the caudal septal cartilage was previously resected. Our results show that septal perforation repair can be safely combined with rhinoplasty and that some of the routine rhinoplasty maneuvers, such as medial osteotomies and dorsal lowering, could even facilitate the process of septal perforation repair.

  8. Combined treatment of esophageal cancer: a review

    International Nuclear Information System (INIS)

    Cesas, A.; Bagajevas, A.

    2004-01-01

    While still relatively uncommon in many countries, esophageal cancer is fatal in the vast majority of cases. In the USA, estimated 13,100 of new cases were diagnosed in 2002. In Lithuania, 163 new cases were diagnosed in 2001. Evidence for an association between environment, diet and esophageal cancer comes from the profound differences in incidence observed in different parts of the world. While the overall outlook for patients diagnosed with esophageal cancer has improved in the last 30 years, most patients are still present with advanced disease and their survival remains poor. Commonly etiology and risk factors of esophageal cancer are: cigarettes and alcohol, diet and other genetics factors. Only in 50% of patients with esophageal cancer clinically localized disease is present. National Comprehensive Cancer Network guidelines state that patients with clinically localized disease may be treated with resection or chemotherapy plus radiation. The overall survival rates for either surgery alone or combined chemotherapy and radiation appear equivalent. Chemoradiation as primary management of localized esophageal cancer has been shown to be superior in radiation alone. A series of randomized trials have demonstrated that adjuvant postoperative chemoradiation does not offer a survival advantage to patients with esophageal cancer. The superiority of preoperative chemoradiation over surgery alone in esophageal cancer has been demonstrated in a prospective trials. Recently published phase I and II studies have demonstrated moderate response rates to taxanes in esophageal cancer. Taxanes and irinotecan in combinations with platinum compounds and fluoropyrimidines are being tested in regimes with radiation. (author)

  9. Checkpoint blockade in combination with cancer vaccines.

    Science.gov (United States)

    Morse, Michael A; Lyerly, H Kim

    2015-12-16

    Checkpoint blockade, prevention of inhibitory signaling that limits activation or function of tumor antigen-specific T cells responses, is revolutionizing the treatment of many poor prognosis malignancies. Indeed monoclonal antibodies that modulate signaling through the inhibitory molecules CTLA-4 and PD-1 are now clinically available; however, many tumors, demonstrate minimal response suggesting the need for combinations with other therapeutic strategies. Because an inadequate frequency of activated tumor antigen-specific T cells in the tumor environment, the so-called non-inflamed phenotype, is observed in some malignancies, other rationale partners are modalities that lead to enhanced T cell activation (vaccines, cytokines, toll-like receptor agonists, and other anticancer therapies such as chemo-, radio- or targeted therapies that lead to release of antigen from tumors). This review will focus on preclinical and clinical data supporting the use of cancer vaccines with anti-CTLA-4 and anti-PD-1/PD-L1 antibodies. Preliminary preclinical data demonstrate enhanced antitumor activity although the results in human studies are less clear. Broader combinations of multiple immune modulators are now under study. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. Combining semantics with non-standard interpreter hierarchies

    DEFF Research Database (Denmark)

    Abramov, Sergei M.; Glück, Robert

    2000-01-01

    This paper reports on results concerning the combination of non-standard semantics via interpreters. We define what a semantics combination means and identify under which conditions a combination can be realized by computer programs (robustness, safely combinable). We develop the underlying mathe...

  11. Combining semantics with non-standard interpreter hierarchies

    DEFF Research Database (Denmark)

    Abramov, Sergei M.; Glück, Robert

    2000-01-01

    This paper reports on results concerning the combination of non-standard semantics via interpreters. We define what a semantics combination means and identify under which conditions a combination can be realized by computer programs (robustness, safely combinable). We develop the underlying...

  12. [Results of combined endotrabeculectomy and phacoemulsification surgery].

    Science.gov (United States)

    Novytskyy, I Ya; Novytskyy, M I

    2015-01-01

    to identify indications and evaluate the efficacy of combined endotrabeculectomy and phacoemulsification surgery. A total of 172 patients (193 eyes) with open-angle glaucoma and cataract were enrolled. Group 1 included 102 patients (118 eyes), who were considered surgical candidates due to decompensation of IOP, group 2--70 patients (75 eyes), in whom IOP control could only be achieved with a multidrug regimen (two or more ocular hypotensive medications). The mean preoperative IOP measured with Maklakov tonometer was 26.4 ± 1.8 mmHg in group 1 and 20.5 ± 1.7 mmHg in group 2. In 134 eyes the extent of retention of intraocular fluid was determined intraoperatively by provoking blood reflux into Schlemm's canal. In 6 out of 134 eyes (4.5%) Schlemm's canal was not at all filled with blood, which was considered a contraindication for endotrabeculectomy. Partial filling of Schlemm's canal with blood was observed in 26 out of 134 eyes (19.4%), complete--in 102 eyes (76.1%). All but 6 patients underwent endotrabeculectomy (ab interno trabecular excision with original forceps through the anterior chamber angle) combined with cataract phacoemulsification and intraocular lens implantation. In 11 out of 126 cases, insignificant bleeding occurred during sample acquisition. No other complications were registered. Six months after the surgery, IOP was reduced by the mean of 7.0 ± 0.6 mmHg (26.5% from the baseline) in group 1 and by 2.2 ± 0.2 mmHg (10.7% from the baseline) in group 2. The number of hypotensive medications by that time has been decreased from 2.3 ± 0.3 to 0.8 ± 0.2 in group 1 and from 1.6 ± 0.3 to 0.4 ± 0.1 in group 2. Combined endotrabeculectomy and phacoemulsification surgery is a pathogenically oriented procedure, which improves ocular hydrodynamics and has a significant hypotensive effect.

  13. Comparative Study: The Military Justice System in Ghana and the United States (Pre-Trial Through Post-Trial): Need for Reforms in Ghana's Military Justice System

    National Research Council Canada - National Science Library

    Allotey, Thomas

    2001-01-01

    .... Both systems were founded on the English common law. Part II of the paper highlighted the colonial administration of the British and the introduction of the English judicial system into then Gold Coast...

  14. 12 CFR 585.40 - What convictions or agreements to enter into pre-trial diversions or similar programs are covered...

    Science.gov (United States)

    2010-01-01

    ..., breach of trust, or money laundering. Convictions do not cover arrests, pending cases not brought to... for a criminal offense involving dishonesty, breach of trust or money laundering. A pretrial diversion...

  15. Combined heat and power in the City

    Energy Technology Data Exchange (ETDEWEB)

    Crafter, A. [Corporation of London (United Kingdom). Dept. of Technical Services

    2002-03-01

    This article reports on the development of a large-scale combined heat and power community energy scheme within the City of London. Supported by the Corporation of London and using its own buildings to provide the heating and cooling loads, the scheme has established a power plant close to Smithfield Meat Market and supplies district heating and chilled water for air conditioning to its own properties and some private customers in the nearby districts. Details are given of the power plant which is sited in a conservation area with limited access, the use of absorption chillers to produce the chilled water, the estimated amount of carbon dioxide emissions saved, and the financial benefits of the scheme.

  16. Theoretically palatable flavor combinations of astrophysical neutrinos

    International Nuclear Information System (INIS)

    Bustamante, Mauricio

    2015-07-01

    The flavor composition of high-energy astrophysical neutrinos can reveal the physics governing their production, propagation, and interaction. The IceCube Collaboration has published the first experimental determination of the ratio of the flux in each flavor to the total. We present, as a theoretical counterpart, new results for the allowed ranges of flavor ratios at Earth for arbitrary flavor ratios in the sources. Our results will allow IceCube to more quickly identify when their data imply standard physics, a general class of new physics with arbitrary (incoherent) combinations of mass eigenstates, or new physics that goes beyond that, e.g., with terms that dominate the Hamiltonian at high energy.

  17. Theoretically Palatable Flavor Combinations of Astrophysical Neutrinos.

    Science.gov (United States)

    Bustamante, Mauricio; Beacom, John F; Winter, Walter

    2015-10-16

    The flavor composition of high-energy astrophysical neutrinos can reveal the physics governing their production, propagation, and interaction. The IceCube Collaboration has published the first experimental determination of the ratio of the flux in each flavor to the total. We present, as a theoretical counterpart, new results for the allowed ranges of flavor ratios at Earth for arbitrary flavor ratios in the sources. Our results will allow IceCube to more quickly identify when their data imply standard physics, a general class of new physics with arbitrary (incoherent) combinations of mass eigenstates, or new physics that goes beyond that, e.g., with terms that dominate the Hamiltonian at high energy.

  18. Combined PET/MR imaging in neurology

    DEFF Research Database (Denmark)

    Andersen, Flemming Littrup; Ladefoged, Claes Nøhr; Beyer, Thomas

    2014-01-01

    on a transaxial T1w-MR image traversing the central basal ganglia. We report the relative difference (%) of the mean ROI values for (A)-(C) in reference to PET/CT (D). In a separate phantom experiment a 2L plastic bottle was layered with approximately 12mm of Gypsum plaster to mimic skull bone. The phantom......AIM: Combined PET/MR systems have now become available for clinical use. Given the lack of integrated standard transmission (TX) sources in these systems, attenuation and scatter correction (AC) must be performed using the available MR-images. Since bone tissue cannot easily be accounted for during...... MR-AC, PET quantification can be biased, in particular, in the vicinity of the skull. Here, we assess PET quantification in PET/MR imaging of patients using phantoms and patient data. MATERIALS AND METHODS: Nineteen patients referred to our clinic for a PET/CT exam as part of the diagnostic...

  19. The Argo NOC: Combining TDM and GALS

    DEFF Research Database (Denmark)

    Kasapaki, Evangelia; Sparsø, Jens

    2015-01-01

    Argo is a network-on-chip developed for use in a multi-core platform designed specifically for hard real-time applications and it supports message passing across virtual end-to-end channels. Argo implements these channels using time-division-multiplexing (TDM) of the resources in the NOC following...... a static schedule. This requires some form of global synchrony across the platform. At the same time it is generally accepted that a large chip should employ some form of globally-asynchronous locally-synchronous (GALS) organization. By using asynchronous routers and by rethinking the microarchitecture...... of the network interfaces we have managed to combine TDM and GALS and obtain a very hardware-efficient implementation of the NOC. The paper gives a brief overview of the Argo NOC and focuses on two important issues: how to safely bring the NOC out of reset and timing analysis of the network of asynchronous...

  20. Design and fabrication of miniature combination lock

    International Nuclear Information System (INIS)

    Yang Gao; Wei Su

    2006-01-01

    Design and fabrication of a miniature combination lock is reported. The prototype's outline size is less than 15mm x 20mm x 25mm, with the function of 24 steps single-try discrimination. Two miniature application-specific electromagnetic motors are used to drive a counter meshing gears (CMG) mechanism. Ratchet-pawl mechanism is respectively attached to each CMG gears assembly, to insure it step forward at accurate angles in company with motor driving circuit. Main functional components of the lock are fabricated by UV-LIGA micromachining process, including the motor's stator with 4-level planar coils. Handcraft assembling process and control circuit design are also briefly introduced. The prototype had already endured more than 1000 times of unlocking and 100 times of manually unlocking. It is proved that micro-motor and micromachining technologies are very useful in miniaturization of such a surety device

  1. COmBined muon reconstruction for Atlas

    CERN Document Server

    Lavrijsen, W T L P; Kittel, E.W.

    2002-01-01

    The Atlas detector, which is being built for the LHC collider experiment at CERN, near Geneva, has as primary objective the discovery or exclusion of the Higgs boson. This boson is an important ingredient of the Standard Model of elementary particles, but has not yet been experimentally established. Atlas contains two tracking subdetectors, separated by a calorimeter, capable of detecting muon trajectories. The best measurement of the parameters of those particles, mostly muons with a large enough energy, that traverse the calorimeter are obtained by a global fit that includes both tracking subdetectors. A software package, COBRA, which implements an abstraction that allows for the application of the same track fit to either subdetector, the global fit, or any arbitrary detector configuration has been developed. The COBRA method and studies of its performance, based on single-track Monte Carlo simulation, are presented. The COBRA package is then used to assess the effect of combined reconstruction on the disc...

  2. Medicine as combining natural and human science.

    Science.gov (United States)

    Dreyfus, Hubert L

    2011-08-01

    Medicine is unique in being a combination of natural science and human science in which both are essential. Therefore, in order to make sense of medical practice, we need to begin by drawing a clear distinction between the natural and the human sciences. In this paper, I try to bring the old distinction between the Geistes and Naturwissenschaften up to date by defending the essential difference between a realist explanatory theoretical study of nature including the body in which the scientist discovers the causal properties of natural kinds and the interpretive understanding of human beings as embodied agents which, as Charles Taylor has convincingly argued, requires a hermeneutic account of self-interpreting human practices.

  3. combined spatially and temporally structured walls

    Directory of Open Access Journals (Sweden)

    D. N. Riahi

    1999-01-01

    Full Text Available Benney's theory of evolution of disturbances in shear flows over smooth and flat boundary is extended to study for shear flows over combined spatially and temporally corrugated walls. Perturbation and multiple-scales analyses are employed for the case where both amplitude of the corrugations and the amplitude of wave motion are small. Analyses for instability of modulated mean shear flows with respect to spanwise-periodic disturbance rolls and for the subsequent vortex formation and vortex stability are presented, and the effects of the corrugated walls on the resulting flow and vortices are determined. It is found that particular corrugated walls can originate and control the longitudinal vortices, while some other types of corrugated walls can enhance instability of such vortices.

  4. Combining Stocks and Flows of Knowledge

    DEFF Research Database (Denmark)

    Ambos, Tina C.; Nell, Phillip Christopher; Pedersen, Torben

    In the area of knowledge management and knowledge governance, previous research has mostly focused on either knowledge stocks or knowledge flows of firms or organizational units. Contrary to this work, our study is among the first to integrate these two perspectives in order to shed light...... on the complementarity effects of different types of knowledge stocks and flows in the multinational corporation (MNC). We investigate intra-functional as well as cross-functional complementarity effects from the perspective of the knowledge recipient. We test the impact of stocks on flows on the benefit that is created...... for MNC units. Based on a comprehensive sample of 324 relationships between MNC units we find that both types of complementarity create benefits for these units, but that the effects from intra-functional combinations of knowledge stocks and flows are significantly stronger than from cross...

  5. Combining engineering and data-driven approaches

    DEFF Research Database (Denmark)

    Fischer, Katharina; De Sanctis, Gianluca; Kohler, Jochen

    2015-01-01

    assumptions that may result in a biased risk assessment. In two related papers we show how engineering and data-driven modelling can be combined by developing generic risk models that are calibrated to statistical data on observed fire events. The focus of the present paper is on the calibration procedure......Two general approaches may be followed for the development of a fire risk model: statistical models based on observed fire losses can support simple cost-benefit studies but are usually not detailed enough for engineering decision-making. Engineering models, on the other hand, require many....... A framework is developed that is able to deal with data collection in non-homogeneous portfolios of buildings. Also incomplete data sets containing only little information on each fire event can be used for model calibration. To illustrate the capabilities of the proposed framework, it is applied...

  6. Combining triggers in HEP data analysis

    International Nuclear Information System (INIS)

    Lendermann, Victor; Herbst, Michael; Krueger, Katja; Schultz-Coulon, Hans-Christian; Stamen, Rainer; Haller, Johannes

    2009-01-01

    Modern high-energy physics experiments collect data using dedicated complex multi-level trigger systems which perform an online selection of potentially interesting events. In general, this selection suffers from inefficiencies. A further loss of statistics occurs when the rate of accepted events is artificially scaled down in order to meet bandwidth constraints. An offline analysis of the recorded data must correct for the resulting losses in order to determine the original statistics of the analysed data sample. This is particularly challenging when data samples recorded by several triggers are combined. In this paper we present methods for the calculation of the offline corrections and study their statistical performance. Implications on building and operating trigger systems are discussed. (orig.)

  7. Combining multiple decisions: applications to bioinformatics

    International Nuclear Information System (INIS)

    Yukinawa, N; Ishii, S; Takenouchi, T; Oba, S

    2008-01-01

    Multi-class classification is one of the fundamental tasks in bioinformatics and typically arises in cancer diagnosis studies by gene expression profiling. This article reviews two recent approaches to multi-class classification by combining multiple binary classifiers, which are formulated based on a unified framework of error-correcting output coding (ECOC). The first approach is to construct a multi-class classifier in which each binary classifier to be aggregated has a weight value to be optimally tuned based on the observed data. In the second approach, misclassification of each binary classifier is formulated as a bit inversion error with a probabilistic model by making an analogy to the context of information transmission theory. Experimental studies using various real-world datasets including cancer classification problems reveal that both of the new methods are superior or comparable to other multi-class classification methods

  8. Rethinking Robot Vision - Combining Shape and Appearance

    Directory of Open Access Journals (Sweden)

    Matthias J. Schlemmer

    2008-11-01

    Full Text Available Equipping autonomous robots with vision sensors provides a multitude of advantages by simultaneously bringing up difficulties with regard to different illumination conditions. Furthermore, especially with service robots, the objects to be handled must somehow be learned for a later manipulation. In this paper we summarise work on combining two different vision sensors, namely a laser range scanner and a monocular colour camera, for shape-capturing, detecting and tracking of objects in cluttered scenes without the need of intermediate user interaction. The use of different sensor types provides the advantage of separating the shape and the appearance of the object and therefore overcome the problem with changing illumination conditions. We describe the framework and its components of visual shape-capturing, fast 3D object detection and robust tracking as well as examples that show the feasibility of this approach.

  9. Malignant mesothelioma clinical trial combines immunotherapy drugs.

    Science.gov (United States)

    Chatwal, Monica S; Tanvetyanon, Tawee

    2018-04-01

    Immunotherapy by checkpoint inhibitor is effective for a number of solid tumors including malignant mesothelioma. Studies utilizing single-agent PD-1 or PD-L1 inhibitor for mesothelioma have reported tumor response rates in approximately 10-20% of patients treated. Given the success of combining these agents with CTLA-4 inhibitor in melanoma, there is a strong rationale to study it in mesothelioma. Recently results from clinical trials investigating this approach have been released. Though limited by small sample size, the studies conclusively demonstrated feasibility and suggested a modestly higher tumor response rate than one would expect from treatment with single-agent PD-1 or PD-L1 inhibitor. Nevertheless, toxicity was also increased. Immunotherapy-related deaths due to encephalitis, renal failure and hepatitis were observed. Further studies are warranted.

  10. Combination nicotine replacement therapy: strategies for initiation and tapering.

    Science.gov (United States)

    Hsia, Stephanie L; Myers, Mark G; Chen, Timothy C

    2017-04-01

    Several studies and meta-analyses have demonstrated the efficacy of combination nicotine replacement therapy (NRT) for patients who wish to quit smoking. However, there is limited guidance with respect to initiation and tapering of combination NRT. We attempt to review the evidence and rationale behind combination NRT, present the dosing used in combination NRT studies, and propose a step-down approach for tapering of combination NRT with integration of behavioral strategies. Copyright © 2017. Published by Elsevier Inc.

  11. Combination Treatment for Nicotine Dependence: State of the Science

    OpenAIRE

    INGERSOLL, KAREN S.; COHEN, JESSYE

    2005-01-01

    Both nicotine replacement and sustained-release buproprion double the odds of achieving short- and moderate-term abstinence from nicotine. However, questions remain about the efficacy of combining pharmacotherapies. Our purposes were to review the evidence for (1) combined pharmacotherapy and (2) multimodal treatment combining pharmacotherapy and behavioral treatment and to recommend combinations of treatments to reduce nicotine dependence. Combining first-line pharmacotherapies with each oth...

  12. Combination and interpretation of observables in Cosmology

    Directory of Open Access Journals (Sweden)

    Virey Jean-Marc

    2010-04-01

    Full Text Available The standard cosmological model has deep theoretical foundations but need the introduction of two major unknown components, dark matter and dark energy, to be in agreement with various observations. Dark matter describes a non-relativistic collisionless fluid of (non baryonic matter which amount to 25% of the total density of the universe. Dark energy is a new kind of fluid not of matter type, representing 70% of the total density which should explain the recent acceleration of the expansion of the universe. Alternatively, one can reject this idea of adding one or two new components but argue that the equations used to make the interpretation should be modified consmological scales. Instead of dark matter one can invoke a failure of Newton's laws. Instead of dark energy, two approaches are proposed : general relativity (in term of the Einstein equation should be modified, or the cosmological principle which fixes the metric used for cosmology should be abandonned. One of the main objective of the community is to find the path of the relevant interpretations thanks to the next generation of experiments which should provide large statistics of observationnal data. Unfortunately, cosmological in formations are difficult to pin down directly fromt he measurements, and it is mandatory to combine the various observables to get the cosmological parameters. This is not problematic from the statistical point of view, but assumptions and approximations made for the analysis may bias our interprettion of the data. Consequently, a strong attention should be paied to the statistical methods used to make parameters estimation and for model testing. After a review of the basics of cosmology where the cosmological parameters are introduced, we discuss the various cosmological probes and their associated observables used to extract cosmological informations. We present the results obtained from several statistical analyses combining data of diferent nature but

  13. Using data from monitoring combined sewer overflows to assess, improve, and maintain combined sewer systems

    OpenAIRE

    Montserrat Royuela, Albert; Bosch, Ll.; Kiser, M.A.; Poch, Manuel; Corominas Tabares, Lluís

    2015-01-01

    Using low-cost sensors, data can be collected on the occurrence and duration of overflows in each combined sewer overflow (CSO) structure in a combined sewer system (CSS). The collection and analysis of real data can be used to assess, improve, and maintain CSSs in order to reduce the number and impact of overflows. The objective of this study was to develop a methodology to evaluate the performance of CSSs using low-cost monitoring. This methodology includes (1) assessing the capacity of a C...

  14. EGSIEM combination service: combination of GRACE monthly K-band solutions on normal equation level

    Science.gov (United States)

    Meyer, Ulrich; Jean, Yoomin; Arnold, Daniel; Jäggi, Adrian

    2017-04-01

    The European Gravity Service for Improved Emergency Management (EGSIEM) project offers a scientific combination service, combining for the first time monthly GRACE gravity fields of different analysis centers (ACs) on normal equation (NEQ) level and thus taking all correlations between the gravity field coefficients and pre-eliminated orbit and instrument parameters correctly into account. Optimal weights for the individual NEQs are commonly derived by variance component estimation (VCE), as is the case for the products of the International VLBI Service (IVS) or the DTRF2008 reference frame realisation that are also derived by combination on NEQ-level. But variance factors are based on post-fit residuals and strongly depend on observation sampling and noise modeling, which both are very diverse in case of the individual EGSIEM ACs. These variance factors do not necessarily represent the true error levels of the estimated gravity field parameters that are still governed by analysis noise. We present a combination approach where weights are derived on solution level, thereby taking the analysis noise into account.

  15. Combining the Observations from Different GNSS (Invited)

    Science.gov (United States)

    Dach, R.; Lutz, S.; Schaer, S.; Bock, H.; Jäggi, A.; Meindl, M.; Ostini, L.; Thaller, D.; Steinbach, A.; Beutler, G.; Steigenberger, P.

    2009-12-01

    For a very long time GPS has clearly dominated the use of GNSS measurements for scientific purposes. This picture is changing: we are moving from a GPS-only to a multi-GNSS world. This is, e.g., reflected by changing the meaning of the abbreviation IGS in March 2005 from International GPS to GNSS Service. The current situation can be described as follows: GPS has the leading role in the GNSS because it has provided a very stable satellite constellation over many years. Some of the currently active GPS satellites are nearly 15 years old. These old satellites are expected to be decommissioned within the next years. On the other hand, due to the increasing number of active GLONASS satellites and the improved density of multi-GNSS tracking stations in the IGS network, the quality of the GLONASS orbits has drastically improved during the last years. The European Galileo system is under development: currently two test satellites (GIOVE-A and GIOVE-B) are in orbit. The IOV (in-orbit-validation phase) will start soon. Also the first test satellites for the Chinese Compass system are in space. For the maximum benefit the observations of these GNSS will be processed in a combined multi-GNSS analysis in future. CODE (Center for Orbit Determination in Europe) is a joint venture between the Astronomical Institute of the University Bern (AIUB, Bern, Switzerland), the Federal Office of Topography (swisstopo, Wabern, Switzerland), the Federal Agency for Cartography and Geodesy (BKG, Frankfurt am Main, Germany), and the Institut für Astronomische und Physikalische Geodäsie of the Technische Universität München (IAPG/TUM, Munich, Germany). It acts as one of the global analysis centers of the IGS and has started in May 2003 with a rigorous combined processing of GPS and GLONASS measurements for the final, rapid, and even ultra-rapid product lines. All contributions from CODE to the IGS are in fact multi-GNSS products -- the only exception is the satellite and receiver clock

  16. Combinations of genetic variants associated with bipolar disorder

    DEFF Research Database (Denmark)

    Mellerup, Erling; Andreassen, Ole A.; Bennike, Bente

    2017-01-01

    The main objective of the study was to find genetic variants that in combination are significantly associated with bipolar disorder. In previous studies of bipolar disorder, combinations of three and four single nucleotide polymorphisms (SNP) genotypes taken from 803 SNPs were analyzed, and five...... clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of ten SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from......, heterozygote or variant homozygote. In the combinations containing 10 SNP genotypes almost all the genotypes were the normal homozygote. Such a finding may indicate that accumulation in the genome of combinations containing few SNP genotypes may be a risk factor for bipolar disorder when those combinations...

  17. NFL Combine Athletic Performance after ACL Reconstruction

    Science.gov (United States)

    Marshall, Nathan E.; Keller, Robert A.; Mehran, Nima; Austin, William; Moutzouros, Vasilios

    2016-01-01

    Objectives: The purpose of this study was to determine the functional performance of NFL combine participants after ACL reconstruction compared with an age-, size-, and position-matched control group. The hypothesis was that there would be no difference between players after ACL reconstruction as compared with controls in functional athletic performance. Methods: A total of 98 NFL-caliber athletes who had undergone primary ACL reconstruction and participated in the NFL scouting combine between 2010 and 2014 were reviewed and compared with an age-, size-, and position-matched control group. Data recorded for each player included a 40-yard dash, vertical leap, broad jump, shuttle drill, and 3-cone drill. Results: With regard to speed and acceleration, the mean 40-yard dash time for ACL-reconstructed players was 4.74 seconds (range, 4.33-5.55 seconds) compared with controls at 4.74 seconds (range, 4.34-5.38 seconds; P = .96). Jumping performance was also similar, with a mean vertical leap for ACL-reconstructed players of 33.35 inches (range, 23-43 inches) and broad jump of 113.9 inches (range, 96-136 inches) compared with respective values for the controls of 33.22 inches (range, 23.5-43.5 inches; P = .84) and 113.9 inches (range, 92-134 inches; P = .99). Agility and quickness testing measures also did not show a statistically significantly difference, with ACL-reconstructed players performing the shuttle drill in 4.37 seconds (range, 4.02-4.84 seconds) and the 3-cone drill in 7.16 seconds (range, 6.45-8.14 seconds), respectively, compared with respective times for the controls of 4.37 seconds (range, 3.96-5.00 seconds; P = .91) and 7.18 seconds (range, 6.64-8.24 seconds; P = .75). Conclusion: This study suggests that after ACL reconstruction, high-caliber athletes can achieve equivalent levels of perfor- mance with no statistically significant differences compared with matched controls. This information is unique when advising high-level athletes on athletic

  18. Efficient Generation and Selection of Combined Features for Improved Classification

    KAUST Repository

    Shono, Ahmad N.

    2014-05-01

    This study contributes a methodology and associated toolkit developed to allow users to experiment with the use of combined features in classification problems. Methods are provided for efficiently generating combined features from an original feature set, for efficiently selecting the most discriminating of these generated combined features, and for efficiently performing a preliminary comparison of the classification results when using the original features exclusively against the results when using the selected combined features. The potential benefit of considering combined features in classification problems is demonstrated by applying the developed methodology and toolkit to three sample data sets where the discovery of combined features containing new discriminating information led to improved classification results.

  19. Combining Electrolysis and Electroporation for Tissue Ablation.

    Science.gov (United States)

    Phillips, Mary; Rubinsky, Liel; Meir, Arie; Raju, Narayan; Rubinsky, Boris

    2015-08-01

    Electrolytic ablation is a method that operates by delivering low magnitude direct current to the target region over long periods of time, generating electrolytic products that destroy cells. This study was designed to explore the hypothesis stating that electrolytic ablation can be made more effective when the electrolysis-producing electric charges are delivered using electric pulses with field strength typical in reversible electroporation protocols. (For brevity we will refer to tissue ablation protocols that combine electroporation and electrolysis as E(2).) The mechanistic explanation of this hypothesis is related to the idea that products of electrolysis generated by E(2) protocols can gain access to the interior of the cell through the electroporation permeabilized cell membrane and therefore cause more effective cell death than from the exterior of an intact cell. The goal of this study is to provide a first-order examination of this hypothesis by comparing the charge dosage required to cause a comparable level of damage to a rat liver, in vivo, when using either conventional electrolysis or E(2) approaches. Our results show that E(2) protocols produce tissue damage that is consistent with electrolytic ablation. Furthermore, E(2) protocols cause damage comparable to that produced by conventional electrolytic protocols while delivering orders of magnitude less charge to the target tissue over much shorter periods of time. © The Author(s) 2014.

  20. Expert judgement combination using moment methods

    International Nuclear Information System (INIS)

    Wisse, Bram; Bedford, Tim; Quigley, John

    2008-01-01

    Moment methods have been employed in decision analysis, partly to avoid the computational burden that decision models involving continuous probability distributions can suffer from. In the Bayes linear (BL) methodology prior judgements about uncertain quantities are specified using expectation (rather than probability) as the fundamental notion. BL provides a strong foundation for moment methods, rooted in work of De Finetti and Goldstein. The main objective of this paper is to discuss in what way expert assessments of moments can be combined, in a non-Bayesian way, to construct a prior assessment. We show that the linear pool can be justified in an analogous but technically different way to linear pools for probability assessments, and that this linear pool has a very convenient property: a linear pool of experts' assessments of moments is coherent if each of the experts has given coherent assessments. To determine the weights of the linear pool we give a method of performance based weighting analogous to Cooke's classical model and explore its properties. Finally, we compare its performance with the classical model on data gathered in applications of the classical model

  1. Combined genetic effects of chemicals and radiation

    International Nuclear Information System (INIS)

    Kada, T.; Inoue, T.; Yokoiyama, A.; Russell, L.B.

    1979-01-01

    The interactions of chemicals and radiation are complex, and there may exist other unexpected patterns. The photodynamic induction of mutation by fluorescein dyes, and the radiosensitization with iodine compounds are classified as the interactions of chemicals and radiation outside cells. On the other hand, the antimutagenic effects of cobaltous chloride is concerned with the events taking place in the cells that had already been exposed to mutagenic agents. It is likely that the action of mutagenic agents is not direct, and that cellular functions, such as mutators or repair systems, are involved in the mutagenesis initiated by the agents. Such cellular functions can be affected by a second agent. In sexually reproducing organisms, two agents can also act on separate cells (male and female germ cells) which subsequently fuse. In mice, the experiments combining the radiation applied to one sex with the chemicals given to the other sex are only in early stages. Males were irradiated with X-ray (spermatozoa and spermatids sampled) and females (mature oocytes) were treated with caffeine. When the endpoint was dominant lethal, the level of X-ray effect induced in the male genome was independent of the caffeine treatment of the female. However, when the endpoint was sex-chromosome-loss, and a different strain of female was used, the caffeine potentiation was statistically significant at 5% level. (Yamashita, S.)

  2. Combined "dual" absorption and fluorescence smartphone spectrometers.

    Science.gov (United States)

    Arafat Hossain, Md; Canning, John; Ast, Sandra; Cook, Kevin; Rutledge, Peter J; Jamalipour, Abbas

    2015-04-15

    A combined "dual" absorption and fluorescence smartphone spectrometer is demonstrated. The optical sources used in the system are the white flash LED of the smartphone and an orthogonally positioned and interchangeable UV (λex=370  nm) and blue (λex=450  nm) LED. The dispersive element is a low-cost, nano-imprinted diffraction grating coated with Au. Detection over a 300 nm span with 0.42 nm/pixel resolution was carried out with the camera CMOS chip. By integrating the blue and UV excitation sources into the white LED circuitry, the entire system is self-contained within a 3D printed case and powered from the smartphone battery; the design can be scaled to add further excitation sources. Using a customized app, acquisition of absorption and fluorescence spectra are demonstrated using a blue-absorbing and green-emitting pH-sensitive amino-naphthalimide-based fluorescent probe and a UV-absorbing and blue-emitting Zn2+-sensitive fluoro-ionophore.

  3. Severe combined immunodeficiency--an update.

    Science.gov (United States)

    Cirillo, Emilia; Giardino, Giuliana; Gallo, Vera; D'Assante, Roberta; Grasso, Fiorentino; Romano, Roberta; Di Lillo, Cristina; Galasso, Giovanni; Pignata, Claudio

    2015-11-01

    Severe combined immunodeficiencies (SCIDs) are a group of inherited disorders responsible for severe dysfunctions of the immune system. These diseases are life-threatening when the diagnosis is made too late; they are the most severe forms of primary immunodeficiency. SCID patients often die during the first two years of life if appropriate treatments to reconstitute their immune system are not undertaken. Conventionally, SCIDs are classified according either to the main pathway affected by the molecular defect or on the basis of the specific immunologic phenotype that reflects the stage where the blockage occurs during the differentiation process. However, during the last few years many new causative gene alterations have been associated with unusual clinical and immunological phenotypes. Many of these novel forms of SCID also show extra-hematopoietic alterations, leading to complex phenotypes characterized by a functional impairment of several organs, which may lead to a considerable delay in the diagnosis. Here we review the biological and clinical features of SCIDs paying particular attention to the most recently identified forms and to their unusual or extra-immunological clinical features. © 2015 New York Academy of Sciences.

  4. A new combined surface and volume registration

    Science.gov (United States)

    Lepore, Natasha; Joshi, Anand A.; Leahy, Richard M.; Brun, Caroline; Chou, Yi-Yu; Pennec, Xavier; Lee, Agatha D.; Barysheva, Marina; De Zubicaray, Greig I.; Wright, Margaret J.; McMahon, Katie L.; Toga, Arthur W.; Thompson, Paul M.

    2010-03-01

    3D registration of brain MRI data is vital for many medical imaging applications. However, purely intensitybased approaches for inter-subject matching of brain structure are generally inaccurate in cortical regions, due to the highly complex network of sulci and gyri, which vary widely across subjects. Here we combine a surfacebased cortical registration with a 3D fluid one for the first time, enabling precise matching of cortical folds, but allowing large deformations in the enclosed brain volume, which guarantee diffeomorphisms. This greatly improves the matching of anatomy in cortical areas. The cortices are segmented and registered with the software Freesurfer. The deformation field is initially extended to the full 3D brain volume using a 3D harmonic mapping that preserves the matching between cortical surfaces. Finally, these deformation fields are used to initialize a 3D Riemannian fluid registration algorithm, that improves the alignment of subcortical brain regions. We validate this method on an MRI dataset from 92 healthy adult twins. Results are compared to those based on volumetric registration without surface constraints; the resulting mean templates resolve consistent anatomical features both subcortically and at the cortex, suggesting that the approach is well-suited for cross-subject integration of functional and anatomic data.

  5. Pixel-Tilecal-MDT Combined Test Beam

    CERN Multimedia

    B. Di Girolamo

    A test with many expectations When an additional week of running (from September 11th to 18th) was allocated for the test-beam, it was decided to give priority to a combined run with the participation of the Pixel, Tilecal and MDT sub-detectors. The integration of these three sub-detectors was possible as they all use the baseline (DAQ-1/EF based) DAQ for test beams (as reported in a previous e-news). The tests and the addition of a common trigger and busy were organized in a short timescale by experts from the three sub-detectors and DAQ/EF. The expectations were many; both looking for problems and finding solutions. The setup The setup, shown in the figure, consisted of the Pixel telescope normally used during the sub-detector tests, two Tilecal barrel modules, two Tilecal extended barrel modules, and six MDT barrel chambers. This fully occupied a length of some 30 meters in the H8 line of the SPS North Area. Each sub-detector used their own specialized front-end electronics. The data collected by modu...

  6. API and ISO standards can be combined

    International Nuclear Information System (INIS)

    Weightman, R.T.; Warnack, M.F.

    1992-01-01

    This paper reports that oil field equipment and product manufacturers can maintain a competitive advantage and minimize costs by integrating American Petroleum Institute (API) licensing programs with International Standards Organization (ISO) 9001 standards under one quality system. A combined quality system approach can position a company for quality system certification under ISO 9001 while maintaining API specifications. Furthermore, only one quality system manual is needed for API licensing and ISO certification, avoiding duplication of effort. The benefits of a documented quality program include the flowing: Job descriptions and personnel qualification requirements are documented; The improved documentation allows direct tracing of specific production activities; Laboratory test methods and calibration of test equipment follow accepted standards for more reliable and reproducible test data; Quality control becomes proactive, not reactive, through internal process controls previously not implemented; Employee attitudes improve through appreciation for the overall goals of the company; Ambiguous quality issues, such as documenting special customer requirements, are easily resolved; and The company image improves with customers, particularly for those that require API Specification Q1 or ISO 9001 compliance or those having their own quality performance standards

  7. How I treat severe combined immunodeficiency.

    Science.gov (United States)

    Gaspar, H Bobby; Qasim, Waseem; Davies, E Graham; Rao, Kanchan; Amrolia, Persis J; Veys, Paul

    2013-11-28

    Severe combined immunodeficiency (SCID) arises from different genetic defects associated with lymphocyte development and function and presents with severe infections. Allogeneic hematopoietic stem cell transplantation is an extremely effective way of restoring immunity in these individuals. Numerous multicenter studies have identified the factors determining successful outcome, and survival for SCID has shown great improvement. Advances in understanding the genetic basis of disease also mean that we increasingly tailor transplant protocols to the specific SCID form. Wherever possible, we attempt to transplant SCID patients without the use of cytoreductive conditioning, but it is clear that this is only successful for specific SCID forms and, although survival is good, in specific patients there are ongoing humoral defects. We aim to use matched related and unrelated donors (including cord blood) whenever possible and have limited the use of mismatched haploidentical donors. The development of autologous hematopoietic stem cell gene therapy provides another treatment of the X-linked and adenosine deaminase-deficient forms of SCID, and we discuss how we have integrated gene therapy into our treatment strategy. These developments together with the advent of universal newborn screening for SCID should allow for a highly favorable outcome for this otherwise lethal condition.

  8. Dual field combination for unmanned video surveillance

    Science.gov (United States)

    Sarrabezolles, Louise; Manzanera, Antoine; Hueber, Nicolas; Perrot, Maxime; Raymond, Pierre

    2017-05-01

    Unmanned systems used for threat detection and identification are still not efficient enough for monitoring autonomously the battlefield. The limitation on size and energy makes those systems unable to use most state- of-the-art computer vision algorithms for recognition. The bio-inspired approach based on the humans peripheral and foveal visions has been reported as a way to combine recognition performance and computational efficiency. As a low resolution camera observes a large zone and detects significant changes, a second camera focuses on each event and provides a high resolution image of it. While such biomimetic existing approaches usually separate the two vision modes according to their functionality (e.g. detection, recognition) and to their basic primitives (i.e. features, algorithms), our approach uses common structures and features for both peripheral and foveal cameras, thereby decreasing the computational load with respect to the previous approaches. The proposed approach is demonstrated using simulated data. The outcome proves particularly attractive for real time embedded systems, as the primitives (features and classifier) have already proven good performances in low power embedded systems. This first result reveals the high potential of dual views fusion technique in the context of long duration unmanned video surveillance systems. It also encourages us to go further into miming the mechanisms of the human eye. In particular, it is expected that adding a retro-action of the fovea towards the peripheral vision will further enhance the quality and efficiency of the detection process.

  9. Combined Treatment of Old Sanitary Landfill Leachate

    Directory of Open Access Journals (Sweden)

    Visnja Orescanin

    2016-06-01

    Full Text Available Landfill leachate presents hardly treatable, highly complex and very toxic environmental effluent originated in the municipal solid waste degradation process. Although, numerous treatment methods were developed so far, none of them alone could achieve permissible limits of the primary pollutants to discharge into natural recipients. The current study aimed to develop and apply the process to treat landfill leachate by simultaneous application of electrochemical methods, ultrasound, electromagnetic field and ozonation to achieve the legal criteria for its discharge into natural recipient and minimize its adverse environmental impacts. For this purpose, old landfill leachate was taken from the Piskornica (Koprivnica, Croatia sanitary landfill. Prior to the treatment, the leachate was supplemented with NaCl (2 g/L and subjected to simultaneous treatment with stainless steel electrode plates, ultrasound and recirculation through electromagnetic field. After 45 minutes, stainless steel electrode plates were replaced by iron electrodes and treated for another 10 minutes followed by 15 minutes of the treatment with aluminum electrode plates. Ultrasound and recirculation through electromagnetic field were also applied during Fe and Al electrode treatment. Finally, the electrodes were removed and the suspension was mixed with ozone for another 30 minutes and allowed to settle for an hour. Following the combined treatment, the removal efficiency for the turbidity, color, suspended solids, ammonium, phosphates and heavy metals was 99% or higher, while the removal of COD was 97%. All the measured parameters in the treated leachate were lower compared to upper permissible limit for discharge into natural recipient.

  10. Combined oral contraceptives: health benefits beyond contraception.

    Science.gov (United States)

    Caserta, D; Ralli, E; Matteucci, E; Bordi, G; Mallozzi, M; Moscarini, M

    2014-09-01

    It has been recognized for over 50 years that combined oral contraceptives (COCs) are also capable of offering health benefits beyond contraception through the treatment and prevention of several gynaecological and medical disorders. During the last years a constant attention was given to the adverse effects of COCs, whereas their non-contraceptive benefits were underestimated. To date, most women are still unaware of the therapeutic uses of hormonal contraceptives, while on the contrary there is an extensive and constantly increasing of these non-contraceptive health benefits. This review summarizes the conditions of special interest for physicians, including dysmenorrhoea, menorrhagia, hyperandrogenism (acne, hirsutism, polycystic ovary syndrome), functional ovarian cysts, endometriosis, premenstrual syndrome, myomas, pelvic inflammatory disease, bone mineral density, benign breast disease and endometrial/ovarian and colorectal cancer. The benefits of COCs in rheumatoid arthritis, multiple sclerosis, menstrual migraine and in perimenopause have also been treated for more comprehensive information. Using COCs specifically for non-contraceptive indications is still outside the product licence in the majority of cases. We strongly believe that these aspects are not of minor relevance and they deserve a special consideration by health providers and by the mass media, which have the main responsibility in the diffusion of scientific information. Thus, counseling and education are necessary to help women make well-informed health-care decisions and it is also crucial to increase awareness among general practitioners and gynaecologists.

  11. Transformative combinations: women's health and human rights.

    Science.gov (United States)

    Yamin, A E

    1997-01-01

    From the human rights perspective proposed in this article, a woman's good or ill health reflects more than biology or individual behaviors; it reflects her enjoyment (or lack thereof) of fundamental human rights that enable her to exercise basic power over the course and quality of her life. The "structural" view of health that such a human rights perspective suggests is concerned first with identifying the effects of social, economic, and political relations on women's health and then with promoting "interventions" aimed at transforming the laws, institutions, and structures that deny women's rights and well-being. Yet, traditional human rights law and practice have been limited to narrowly defined abuses by public officials against individuals that fail to capture the most pervasive denials of women's rights, which, though rooted in systematic discrimination, are frequently played out in so-called "private" institutions, primarily within the family. The experiences of women's health advocates in addressing complex women's health issues makes it clear that women's lack of access to economic and political power in the public sphere creates the conditions under which they are discriminated against and physically and sexually abused in the private sphere. Combining the pragmatic understanding of women's health professionals with an expansive conception of human rights norms has the potential to transform the fields of women's health and human rights.

  12. Combining forecast weights: Why and how?

    Science.gov (United States)

    Yin, Yip Chee; Kok-Haur, Ng; Hock-Eam, Lim

    2012-09-01

    This paper proposes a procedure called forecast weight averaging which is a specific combination of forecast weights obtained from different methods of constructing forecast weights for the purpose of improving the accuracy of pseudo out of sample forecasting. It is found that under certain specified conditions, forecast weight averaging can lower the mean squared forecast error obtained from model averaging. In addition, we show that in a linear and homoskedastic environment, this superior predictive ability of forecast weight averaging holds true irrespective whether the coefficients are tested by t statistic or z statistic provided the significant level is within the 10% range. By theoretical proofs and simulation study, we have shown that model averaging like, variance model averaging, simple model averaging and standard error model averaging, each produces mean squared forecast error larger than that of forecast weight averaging. Finally, this result also holds true marginally when applied to business and economic empirical data sets, Gross Domestic Product (GDP growth rate), Consumer Price Index (CPI) and Average Lending Rate (ALR) of Malaysia.

  13. PANSAID - PAracetamol and NSAID in combination

    DEFF Research Database (Denmark)

    Thybo, Kasper Højgaard; Hägi-Pedersen, Daniel; Wetterslev, Jørn

    2017-01-01

    compared to monotherapy. The objective of this trial is to investigate the analgesic effects and safety of paracetamol and ibuprofen alone and in combination in different dosages after THA. METHODS: PANSAID is a placebo-controlled, parallel four-group, multicentre trial with centralised computer......-generated allocation sequence and allocation concealment and with varying block size and stratification by site. Blinding of assessor, investigator, caregivers, patients and statisticians. Patients are randomised to four groups: (A) paracetamol 1 g × 4 and ibuprofen 400 mg × 4, (B) paracetamol 1 g × 4 and placebo, (C......) placebo and ibuprofen 400 mg × 4 and (D) paracetamol 0.5 g × 4 and ibuprofen 200 mg. The two co-primary outcomes are 24-h consumption of morphine and number of patients with one or more serious adverse events within 90 days after surgery. Secondary outcomes are pain scores during mobilisation and at rest...

  14. Combined Radiation Belt - Plasma Sheet System Modeling

    Science.gov (United States)

    Aseev, Nikita; Shprits, Yuri; Kellerman, Adam; Drozdov, Alexander; Zhu, Hui

    2017-04-01

    Recent years have given rise to numerous mathematical models of the Earth's radiation belt dynamics. Driven by observations at geosynchronous orbit (GEO) where satellites (e.g. GOES and LANL) provide extensive in-situ measurements, radiation belt models usually take into account only diffusion processes in the energetic electron belts (100 keV and greater), leaving aside the dynamics of colder source population (tens of keV). Such models are able to reconstruct the radiation belt state, but they are not capable of predicting the electron dynamics at GEO, where many communication and navigation satellites currently operate. In this work we present combined four-dimensional electron radiation belt - plasma sheet model accounting for adiabatic advective transport, radial diffusion due to interaction with ULF waves, local acceleration of electrons, scattering into the atmosphere, magnetopause shadowing, and adiabatic effects due to contraction and expansion of the magnetic field. The developed model is applicable to energetic, relativistic and ultrarelativistic electrons as well as to source electron population. The model provides spatial particle distribution allowing us to compare and validate the model with multiple satellite measurements at different MLT sectors (e.g. Van Allen Probes, GOES, LANL, THEMIS). The model can be helpful for the prediction of crucial for satellite operators geosynchronous electron fluxes and electron radiation belt dynamics including the heart of the outer belt, slot region and inner belt.

  15. Sweden: Combining childbearing and gender equality

    Directory of Open Access Journals (Sweden)

    Eva Bernhardt

    2008-07-01

    Full Text Available Sweden is the forerunner of the Second Demographic Transition. Fertility trends have fluctuated greatly since the 1960s, and the 1990s showed both European-highest and lowest-ever-in-Sweden levels, while the cohort pattern has been relatively stable. Period fluctuations have been accompanied by a postponement of entering committed partnerships and parenthood as well as an increasing instability of family relationships. The awareness and the availability of effective contraceptives have been extensive since the mid-1970s, the year the liberal abortion law was introduced. Post-modern values are dominant in this highly secularized society, but ideal family size is among the highest in the European Union, and childlessness has remained at a relatively low level. Ethnic diversification has increased over time, with about one-fifth of the population having a 'foreign background' in the early 2000s. The level of female labor-force participation is the highest in Europe (although mothers of pre-schoolers often work part-time, and young women are just as highly educated as men. Family policies, based on the principle of equality across social groups and gender, seem to play an important role in keeping fertility relatively high. In combination with other factors, family policies also play a role in the fluctuations of fertility rates, as eligibility to parental-leave and benefits as well as the availability of public childcare are linked to parents' labor-force attachment.

  16. Small scale combined woodgas power plant

    International Nuclear Information System (INIS)

    Gulbis, V.

    2003-01-01

    As a first attempt to introduce biomass gasification technology in Latvia at the Faculty of Engineering of Latvia University of Agriculture an integral small scale combined heat and power (CHP) system based on a used Russian-made diesel-alternator set with electrical output 100 kWe was developed. The diesel is converted to dual fuel gas engine, using producer gas as the main fuel and gas oil as pilot fuel. To get sufficiently clean (tar content ≤ 250 mg/m 3 ) woodgas for using in IC engine a downdraft type of gasifier was chosen designed and constructed on the IMBERT gasifier principles. The test runs of the first experimental model showed that the engine does not develop expected power because of high resistance of gasifier and gas cleaning system does not work sufficiently enough. There was rather high level of tar content in woodgas because the temperature in the reduction zone was low. Calculations were carried out and new technological scheme of gasification system was worked out, introducing innovative ideas aimed on improving the working parameters (author)

  17. Combined therapy for post-irradiation infection

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, T.B.; Madonna, G.S.; Ledney, G.D.; Brook, I.

    1989-01-01

    Increased susceptibility to bacterial infection, probably by translocation from the intestinal flora, can be a lethal complication for 2-3 weeks after exposure to ionizing radiation. Antibiotics alone do not provide adequate therapy for induced infections in neutropenic mice. Because some substances that are derived from bacterial cell walls activate macrophages and stimulate nonspecific resistance to infection, such agents might be used to prevent or treat postirradiation infections. In this study, a cell-wall glycolipid, trehalose dimycolate (TDM), was evaluated together with a third-generation cephalosporin, ceftriaxone, for their separate and combined effects on survival of B6D2F1 female mice that were exposed to the sublethal dose of 7.0 Gy Co radiation and challenged s.c. with lethal doses of Klebsiella pneumoniae. A single injection of TDM inoculated i.p. 1 hr postirradiation increased 30-day survival to 80% after a lethal challenge by K. pneumoniae 4 days later. When the challenge dose of K. pneumoniae was increased to 5000 Ld 50/30 on Day 4, all mice died.

  18. Combined Heuristic Attack Strategy on Complex Networks

    Directory of Open Access Journals (Sweden)

    Marek Šimon

    2017-01-01

    Full Text Available Usually, the existence of a complex network is considered an advantage feature and efforts are made to increase its robustness against an attack. However, there exist also harmful and/or malicious networks, from social ones like spreading hoax, corruption, phishing, extremist ideology, and terrorist support up to computer networks spreading computer viruses or DDoS attack software or even biological networks of carriers or transport centers spreading disease among the population. New attack strategy can be therefore used against malicious networks, as well as in a worst-case scenario test for robustness of a useful network. A common measure of robustness of networks is their disintegration level after removal of a fraction of nodes. This robustness can be calculated as a ratio of the number of nodes of the greatest remaining network component against the number of nodes in the original network. Our paper presents a combination of heuristics optimized for an attack on a complex network to achieve its greatest disintegration. Nodes are deleted sequentially based on a heuristic criterion. Efficiency of classical attack approaches is compared to the proposed approach on Barabási-Albert, scale-free with tunable power-law exponent, and Erdős-Rényi models of complex networks and on real-world networks. Our attack strategy results in a faster disintegration, which is counterbalanced by its slightly increased computational demands.

  19. Combined oral contraceptives affect liver mitochondrial activity.

    Science.gov (United States)

    Jonderko, Krzysztof; Skałba, Piotr; Kamińska, Magdalena; Kasicka-Jonderko, Anna; Galas, Ewa; Biały, Aleksandra

    2013-10-01

    To examine liver mitochondrial function in women using combined oral contraceptives (COCs) containing ethinylestradiol. A breath test after oral administration of 1 mg/kg (13)C-alpha-ketoisocaproic acid ((13)C-KICA) and 20 mg/kg L-leucine was performed twice: (i) in 15 women on day 14, 15, 16, 17 or 18 of COC intake, and between day 1 and 5 of the withdrawal bleeding; and (ii) in 15 regularly menstruating females not taking hormonal contraceptives: during the luteal phase, between the 18th and the 22nd day of the cycle, and again between day 1 and 5 of the menstruation. In women on COCs the maximum (13)C elimination in breath air (Dmax) was higher (26.8 ± 1.6%/h) than during withdrawal bleeding (23.5 ± 1.2%/h; p = 0.012). The time to reach the Dmax was similar on the two study days: 33.3 ± 2.4 min during the phase of pill intake vs. 37.0 ± 2.5 min during the pill-free interval. The one-hour cumulative breath (13)C elimination was greater after two weeks of COC intake than during the withdrawal bleeding: 17.49 ± 1.03% vs. 15.32 ± 0.85% (p = 0.024). In the control group no menstrual cycle phase-dependent fluctuations in the results of the (13)C-KICA breath test were observed. The metabolism of (13)C-alpha-ketoisocaproic acid augments during the intake of COCs containing ethinylestradiol, reflecting enhanced liver mitochondrial metabolic activity.

  20. Combined hostile fire and optics detection

    Science.gov (United States)

    Brännlund, Carl; Tidström, Jonas; Henriksson, Markus; Sjöqvist, Lars

    2013-10-01

    Snipers and other optically guided weapon systems are serious threats in military operations. We have studied a SWIR (Short Wave Infrared) camera-based system with capability to detect and locate snipers both before and after shot over a large field-of-view. The high frame rate SWIR-camera allows resolution of the temporal profile of muzzle flashes which is the infrared signature associated with the ejection of the bullet from the rifle. The capability to detect and discriminate sniper muzzle flashes with this system has been verified by FOI in earlier studies. In this work we have extended the system by adding a laser channel for optics detection. A laser diode with slit-shaped beam profile is scanned over the camera field-of-view to detect retro reflection from optical sights. The optics detection system has been tested at various distances up to 1.15 km showing the feasibility to detect rifle scopes in full daylight. The high speed camera gives the possibility to discriminate false alarms by analyzing the temporal data. The intensity variation, caused by atmospheric turbulence, enables discrimination of small sights from larger reflectors due to aperture averaging, although the targets only cover a single pixel. It is shown that optics detection can be integrated in combination with muzzle flash detection by adding a scanning rectangular laser slit. The overall optics detection capability by continuous surveillance of a relatively large field-of-view looks promising. This type of multifunctional system may become an important tool to detect snipers before and after shot.

  1. Severe combined immunodeficiency: a national surveillance study.

    Science.gov (United States)

    Yee, Anthony; De Ravin, Suk See; Elliott, Elizabeth; Ziegler, John B

    2008-06-01

    National immunodeficiency registers in several countries have reported prevalence but not incidence rates for severe combined immunodeficiency (SCID). The objective of this study was to document the incidence and type of SCID in Australia, the age and clinical features at presentation and short-term management. The Australian Paediatric Surveillance Unit conducts active, monthly, national surveillance of rare disorders with reporting by child-health specialists. Between May 1995 and December 2001, clinicians provided clinical and laboratory data on children newly diagnosed with SCID. Thirty-three incident cases of SCID were identified [incidence 1.8/10(5) live births per annum; 95% confidence interval (CI) 1.2-2.5]. Twenty-six children had classical SCID (1.45/10(5) live births; 95% CI, 0.9-2.0) and 20 (77%) of these were boys. Classical SCID was X-linked in 13 children, autosomal recessive (AR), not further classified in four, and attributed to adenosine deaminase deficiency (ADA) in four, interleukin-7 receptor alpha chain deficiency in one, Ommen syndrome in two, and Di George syndrome in two. Twenty-one (81%) received bone marrow/stem cell transplantation, three of whom died between 1 and 4 months after transplantation (two ADA deficient, one AR). Seven children had atypical SCID, five of whom died within 1-4 yr of diagnosis. Most children with SCID presented with failure to thrive and recurrent infections and there was no significant delay between presentation and diagnosis. The reported national incidence of classical SCID in Australia (1.45/10(5) or approximately 4 cases per year or 1/69,000 live births) is consistent with the rate (1.4/10(5)) previously reported in Victoria. Diagnosis is rarely delayed, and transplantation is associated with good short-term survival.

  2. A combined constraint handling framework: an empirical study

    DEFF Research Database (Denmark)

    Si, Chengyong; Hu, Junjie; Lan, Tian

    2017-01-01

    This paper presents a new combined constraint handling framework (CCHF) for solving constrained optimization problems (COPs). The framework combines promising aspects of different constraint handling techniques (CHTs) in different situations with consideration of problem characteristics. In order...

  3. Locations of Combined Sewer Overflow Outfalls - US EPA Region 3

    Data.gov (United States)

    U.S. Environmental Protection Agency — This data layer identifies the locations of Combined sewer overflow outfalls. Combined sewer systems are sewers that are designed to collect rainwater runoff,...

  4. Therapeutic cancer vaccines in combination with conventional therapy

    DEFF Research Database (Denmark)

    Andersen, Mads Hald; Junker, Niels; Ellebaek, Eva

    2010-01-01

    The clinical efficacy of most therapeutic vaccines against cancer has not yet met its promise. Data are emerging that strongly support the notion that combining immunotherapy with conventional therapies, for example, radiation and chemotherapy may improve efficacy. In particular combination...

  5. Combinations of Genetic Variants Occurring Exclusively in Patients

    DEFF Research Database (Denmark)

    Mellerup, Erling Thyge; Møller, Gert Lykke

    2017-01-01

    The main objective of the study was to find genetic variants that in combination are significantly associated with bipolar disorder. In previous studies of bipolar disorder, combinations of three and four single nucleotide polymorphisms (SNP) genotypes taken from 803 SNPs were analyzed, and five...... clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of ten SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from...... the new cluster and from the five previous clusters were identified in the genomes of 266 or 44% of the 607 patients in the study whereas none of the 1355 control participants had any of these combinations in their genome.The SNP genotypes in the smaller combinations were the normal homozygote...

  6. Treatment of premature ejaculation: a new combined approach

    Directory of Open Access Journals (Sweden)

    Adel Kurkar

    2015-01-01

    Causes of PE differ considerably. In this paper, we compared the outcomes of two single treatment lines together with a combination of both. The combination therapy was more effective than either line alone.

  7. Combination syringe provides air-free blood samples

    Science.gov (United States)

    Pool, S. L.

    1970-01-01

    Standard syringe and spinal needle are combined in unique manner to secure air-free blood samples. Combination syringe obtains air free samples because air bubbles become insignificant when samples greater than 1 cc are drawn.

  8. Infliximab, azathioprine, or combination therapy for Crohn's disease

    DEFF Research Database (Denmark)

    Colombel, Jean Frédéric; Sandborn, William J; Reinisch, Walter

    2010-01-01

    The comparative efficacy and safety of infliximab and azathioprine therapy alone or in combination for Crohn's disease are unknown.......The comparative efficacy and safety of infliximab and azathioprine therapy alone or in combination for Crohn's disease are unknown....

  9. Combined Studies of the EM Calorimeter and the Inner Detector in the 2004 ATLAS Combined Testbeam

    CERN Document Server

    Froeschl, R; The ATLAS collaboration

    2009-01-01

    In 2004 at the ATLAS combined test beam, one slice of the ATLAS barrel detector (including an Inner Detector set-up and the Liquid Argon (LAr) calorimeter) was exposed to particles from the H8 SPS beam line at CERN. It was the first occasion to test the combined electron performance of ATLAS. This presentation will show the results obtained for the electromagnetic performance of the LAr calorimeter (linearity, uniformity and resolution). Results obtained with a very low energy set-up (electron energies down to 1GeV) will be presented validating the LAr electromagnetic energy reconstruction down to very low energies. Results obtained for the E/p ratio and a way how to extract scale parameters will be shown. Studies on Bremstrahlungs-recovery algorithms relying on the LAr calorimeter will be discussed on the basis of results obtained in the testbeam.

  10. Combined performance studies for electrons at the 2004 ATLAS combined test-beam

    Science.gov (United States)

    Abat, E.; Abdallah, J. M.; Addy, T. N.; Adragna, P.; Aharrouche, M.; Ahmad, A.; Akesson, T. P. A.; Aleksa, M.; Alexa, C.; Anderson, K.; Andreazza, A.; Anghinolfi, F.; Antonaki, A.; Arabidze, G.; Arik, E.; Atkinson, T.; Baines, J.; Baker, O. K.; Banfi, D.; Baron, S.; Barr, A. J.; Beccherle, R.; Beck, H. P.; Belhorma, B.; Bell, P. J.; Benchekroun, D.; Benjamin, D. P.; Benslama, K.; Bergeaas Kuutmann, E.; Bernabeu, J.; Bertelsen, H.; Binet, S.; Biscarat, C.; Boldea, V.; Bondarenko, V. G.; Boonekamp, M.; Bosman, M.; Bourdarios, C.; Broklova, Z.; Burckhart Chromek, D.; Bychkov, V.; Callahan, J.; Calvet, D.; Canneri, M.; Capeáns Garrido, M.; Caprini, M.; Cardiel Sas, L.; Carli, T.; Carminati, L.; Carvalho, J.; Cascella, M.; Castillo, M. V.; Catinaccio, A.; Cauz, D.; Cavalli, D.; Cavalli Sforza, M.; Cavasinni, V.; Cetin, S. A.; Chen, H.; Cherkaoui, R.; Chevalier, L.; Chevallier, F.; Chouridou, S.; Ciobotaru, M.; Citterio, M.; Clark, A.; Cleland, B.; Cobal, M.; Cogneras, E.; Conde Muino, P.; Consonni, M.; Constantinescu, S.; Cornelissen, T.; Correard, S.; Corso Radu, A.; Costa, G.; Costa, M. J.; Costanzo, D.; Cuneo, S.; Cwetanski, P.; Da Silva, D.; Dam, M.; Dameri, M.; Danielsson, H. O.; Dannheim, D.; Darbo, G.; Davidek, T.; De, K.; Defay, P. O.; Dekhissi, B.; Del Peso, J.; Del Prete, T.; Delmastro, M.; Derue, F.; Di Ciaccio, L.; Di Girolamo, B.; Dita, S.; Dittus, F.; Djama, F.; Djobava, T.; Dobos, D.; Dobson, M.; Dolgoshein, B. A.; Dotti, A.; Drake, G.; Drasal, Z.; Dressnandt, N.; Driouchi, C.; Drohan, J.; Ebenstein, W. L.; Eerola, P.; Efthymiopoulos, I.; Egorov, K.; Eifert, T. F.; Einsweiler, K.; El Kacimi, M.; Elsing, M.; Emelyanov, D.; Escobar, C.; Etienvre, A. I.; Fabich, A.; Facius, K.; Fakhr-Edine, A. I.; Fanti, M.; Farbin, A.; Farthouat, P.; Fassouliotis, D.; Fayard, L.; Febbraro, R.; Fedin, O. L.; Fenyuk, A.; Fergusson, D.; Ferrari, P.; Ferrari, R.; Ferreira, B. C.; Ferrer, A.; Ferrere, D.; Filippini, G.; Flick, T.; Fournier, D.; Francavilla, P.; Francis, D.; Froeschl, R.; Froidevaux, D.; Fullana, E.; Gadomski, S.; Gagliardi, G.; Gagnon, P.; Gallas, M.; Gallop, B. J.; Gameiro, S.; Gan, K. K.; Garcia, R.; Garcia, C.; Gavrilenko, I. L.; Gemme, C.; Gerlach, P.; Ghodbane, N.; Giakoumopoulou, V.; Giangiobbe, V.; Giokaris, N.; Glonti, G.; Goettfert, T.; Golling, T.; Gollub, N.; Gomes, A.; Gomez, M. D.; Gonzalez-Sevilla, S.; Goodrick, M. J.; Gorfine, G.; Gorini, B.; Goujdami, D.; Grahn, K.-J.; Grenier, P.; Grigalashvili, N.; Grishkevich, Y.; Grosse-Knetter, J.; Gruwe, M.; Guicheney, C.; Gupta, A.; Haeberli, C.; Haertel, R.; Hajduk, Z.; Hakobyan, H.; Hance, M.; Hansen, J. D.; Hansen, P. H.; Hara, K.; Harvey, A., Jr.; Hawkings, R. J.; Heinemann, F. E. W.; Henriques Correia, A.; Henss, T.; Hervas, L.; Higon, E.; Hill, J. C.; Hoffman, J.; Hostachy, J. Y.; Hruska, I.; Hubaut, F.; Huegging, F.; Hulsbergen, W.; Hurwitz, M.; Iconomidou-Fayard, L.; Jansen, E.; Jen-La Plante, I.; Johansson, P. D. C.; Jon-And, K.; Joos, M.; Jorgensen, S.; Joseph, J.; Kaczmarska, A.; Kado, M.; Karyukhin, A.; Kataoka, M.; Kayumov, F.; Kazarov, A.; Keener, P. T.; Kekelidze, G. D.; Kerschen, N.; Kersten, S.; Khomich, A.; Khoriauli, G.; Khramov, E.; Khristachev, A.; Khubua, J.; Kittelmann, T. H.; Klingenberg, R.; Klinkby, E. B.; Kodys, P.; Koffas, T.; Kolos, S.; Konovalov, S. P.; Konstantinidis, N.; Kopikov, S.; Korolkov, I.; Kostyukhin, V.; Kovalenko, S.; Kowalski, T. Z.; Krüger, K.; Kramarenko, V.; Kudin, L. G.; Kulchitsky, Y.; Lacasta, C.; Lafaye, R.; Laforge, B.; Lampl, W.; Lanni, F.; Laplace, S.; Lari, T.; Le Bihan, A.-C.; Lechowski, M.; Ledroit-Guillon, F.; Lehmann, G.; Leitner, R.; Lelas, D.; Lester, C. G.; Liang, Z.; Lichard, P.; Liebig, W.; Lipniacka, A.; Lokajicek, M.; Louchard, L.; Lourerio, K. F.; Lucotte, A.; Luehring, F.; Lund-Jensen, B.; Lundberg, B.; Ma, H.; Mackeprang, R.; Maio, A.; Maleev, V. P.; Malek, F.; Mandelli, L.; Maneira, J.; Mangin-Brinet, M.; Manousakis, A.; Mapelli, L.; Marques, C.; Garcia, S. Marti i.; Martin, F.; Mathes, M.; Mazzanti, M.; McFarlane, K. W.; McPherson, R.; Mchedlidze, G.; Mehlhase, S.; Meirosu, C.; Meng, Z.; Meroni, C.; Mialkovski, V.; Mikulec, B.; Milstead, D.; Minashvili, I.; Mindur, B.; Mitsou, V. A.; Moed, S.; Monnier, E.; Moorhead, G.; Morettini, P.; Morozov, S. V.; Mosidze, M.; Mouraviev, S. V.; Moyse, E. W. J.; Munar, A.; Myagkov, A.; Nadtochi, A. V.; Nakamura, K.; Nechaeva, P.; Negri, A.; Nemecek, S.; Nessi, M.; Nesterov, S. Y.; Newcomer, F. M.; Nikitine, I.; Nikolaev, K.; Nikolic-Audit, I.; Ogren, H.; Oh, S. H.; Oleshko, S. B.; Olszowska, J.; Onofre, A.; Padilla Aranda, C.; Paganis, S.; Pallin, D.; Pantea, D.; Paolone, V.; Parodi, F.; Parsons, J.; Parzhitskiy, S.; Pasqualucci, E.; Passmored, S. M.; Pater, J.; Patrichev, S.; Peez, M.; Perez Reale, V.; Perini, L.; Peshekhonov, V. D.; Petersen, J.; Petersen, T. C.; Petti, R.; Phillips, P. W.; Pina, J.; Pinto, B.; Podlyski, F.; Poggioli, L.; Poppleton, A.; Poveda, J.; Pralavorio, P.; Pribyl, L.; Price, M. J.; Prieur, D.; Puigdengoles, C.; Puzo, P.; RØhne, O.; Ragusa, F.; Rajagopalan, S.; Reeves, K.; Reisinger, I.; Rembser, C.; Bruckman de Renstrom, P. A.; Reznicek, P.; Ridel, M.; Risso, P.; Riu, I.; Robinson, D.; Roda, C.; Roe, S.; Rohne, O.; Romaniouk, A.; Rousseau, D.; Rozanov, A.; Ruiz, A.; Rusakovich, N.; Rust, D.; Ryabov, Y. F.; Ryjov, V.; Salto, O.; Salvachua, B.; Salzburger, A.; Sandaker, H.; Santamarina Rios, C.; Santi, L.; Santoni, C.; Saraiva, J. G.; Sarri, F.; Sauvage, G.; Says, L. P.; Schaefer, M.; Schegelsky, V. A.; Schiavi, C.; Schieck, J.; Schlager, G.; Schlereth, J.; Schmitt, C.; Schultes, J.; Schwemling, P.; Schwindling, J.; Seixas, J. M.; Seliverstov, D. M.; Serin, L.; Sfyrla, A.; Shalanda, N.; Shaw, C.; Shin, T.; Shmeleva, A.; Silva, J.; Simion, S.; Simonyan, M.; Sloper, J. E.; Smirnov, S. Yu; Smirnova, L.; Solans, C.; Solodkov, A.; Solovianov, O.; Soloviev, I.; Sosnovtsev, V. V.; Spanò, F.; Speckmayer, P.; Stancu, S.; Stanek, R.; Starchenko, E.; Straessner, A.; Suchkov, S. I.; Suk, M.; Szczygiel, R.; Tarrade, F.; Tartarelli, F.; Tas, P.; Tayalati, Y.; Tegenfeldt, F.; Teuscher, R.; Thioye, M.; Tikhomirov, V. O.; Timmermans, C. J. W. P.; Tisserant, S.; Toczek, B.; Tremblet, L.; Troncon, C.; Tsiareshka, P.; Tyndel, M.; Karagoez Unel, M.; Unal, G.; Unel, G.; Usai, G.; Van Berg, R.; Valero, A.; Valkar, S.; Valls, J. A.; Vandelli, W.; Vannucci, F.; Vartapetian, A.; Vassilakopoulos, V. I.; Vasilyeva, L.; Vazeille, F.; Vernocchi, F.; Vetter-Cole, Y.; Vichou, I.; Vinogradov, V.; Virzi, J.; Vivarelli, I.; de Vivie, J. B.; Volpi, M.; Anh, T. Vu; Wang, C.; Warren, M.; Weber, J.; Weber, M.; Weidberg, A. R.; Weingarten, J.; Wells, P. S.; Werner, P.; Wheeler, S.; Wiessmann, M.; Wilkens, H.; Williams, H. H.; Wingerter-Seez, I.; Yasu, Y.; Zaitsev, A.; Zenin, A.; Zenis, T.; Zenonos, Z.; Zhang, H.; Zhelezko, A.; Zhou, N.

    2010-11-01

    In 2004 at the ATLAS (A Toroidal LHC ApparatuS) combined test beam, one slice of the ATLAS barrel detector (including an Inner Detector set-up and the Liquid Argon calorimeter) was exposed to particles from the H8 SPS beam line at CERN. It was the first occasion to test the combined electron performance of ATLAS. This paper presents results obtained for the momentum measurement p with the Inner Detector and for the performance of the electron measurement with the LAr calorimeter (energy E linearity and resolution) in the presence of a magnetic field in the Inner Detector for momenta ranging from 20 GeV/c to 100 GeV/c. Furthermore the particle identification capabilities of the Transition Radiation Tracker, Bremsstrahlungs-recovery algorithms relying on the LAr calorimeter and results obtained for the E/p ratio and a way how to extract scale parameters will be discussed.

  11. Coherently combined 16-channel multicore fiber laser system.

    Science.gov (United States)

    Klenke, A; Müller, M; Stark, H; Stutzki, F; Hupel, C; Schreiber, T; Tünnermann, A; Limpert, J

    2018-04-01

    We present a coherently combined laser amplifier with 16 channels from a multicore fiber in a proof-of-principle demonstration. Filled-aperture beam splitting and combination, together with temporal phasing, is realized in a compact and low-component-count setup. Combined average power of up to 70 W with 40 ps pulses is achieved with combination efficiencies around 80%.

  12. Evaluation of Severe Combined Immunodeficiency and Combined Immunodeficiency Pediatric Patients on the Basis of Cellular Radiosensitivity.

    Science.gov (United States)

    Lobachevsky, Pavel; Woodbine, Lisa; Hsiao, Kuang-Chih; Choo, Sharon; Fraser, Chris; Gray, Paul; Smith, Jai; Best, Nickala; Munforte, Laura; Korneeva, Elena; Martin, Roger F; Jeggo, Penny A; Martin, Olga A

    2015-09-01

    Pediatric patients with severe or nonsevere combined immunodeficiency have increased susceptibility to severe, life-threatening infections and, without hematopoietic stem cell transplantation, may fail to thrive. A subset of these patients have the radiosensitive (RS) phenotype, which may necessitate conditioning before hematopoietic stem cell transplantation, and this conditioning includes radiomimetic drugs, which may significantly affect treatment response. To provide statistical criteria for classifying cellular response to ionizing radiation as the measure of functional RS screening, we analyzed the repair capacity and survival of ex vivo irradiated primary skin fibroblasts from five dysmorphic and/or developmentally delayed pediatric patients with severe combined immunodeficiency and combined immunodeficiency. We developed a mathematical framework for the analysis of γ histone 2A isoform X foci kinetics to quantitate DNA-repair capacity, thus establishing crucial criteria for identifying RS. The results, presented in a diagram showing each patient as a point in a 2D RS map, were in agreement with findings from the assessment of cellular RS by clonogenic survival and from the genetic analysis of factors involved in the nonhomologous end-joining repair pathway. We provide recommendations for incorporating into clinical practice the functional assays and genetic analysis used for establishing RS status before conditioning. This knowledge would enable the selection of the most appropriate treatment regimen, reducing the risk for severe therapy-related adverse effects. Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

  13. 49 CFR 262.17 - Combining grant awards.

    Science.gov (United States)

    2010-10-01

    ... IMPROVEMENT PROJECTS § 262.17 Combining grant awards. Two or more States, but not political subdivisions of States, may, pursuant to an agreement entered into by the States, combine any part of the amounts... 49 Transportation 4 2010-10-01 2010-10-01 false Combining grant awards. 262.17 Section 262.17...

  14. 33 CFR 86.13 - Combined whistle systems.

    Science.gov (United States)

    2010-07-01

    ... systems. (a) A combined whistle system is a number of whistles (sound emitting sources) operated together... evidenced by at least two-thirds of the whistles in the combined system having fundamental frequencies... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Combined whistle systems. 86.13...

  15. 19 CFR 134.14 - Articles usually combined.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Articles usually combined. 134.14 Section 134.14... TREASURY COUNTRY OF ORIGIN MARKING Articles Subject to Marking § 134.14 Articles usually combined. (a) Articles combined before delivery to purchaser. When an imported article is of a kind which is usually...

  16. Preliminary evaluation of the combined anticonvulsant activities of ...

    African Journals Online (AJOL)

    The percentage inhibition of the combined extracts shows 50 mg/kg:50 mg/kg ratio NBL/MP had the highest inhibition of 61.17 %. This may justify this ethnomedicinal combination since this was achieved at low doses of the respective constituent herbs. The order of decreasing inhibition by the combinations is 50:50 NBL/MP ...

  17. Insulin delivery systems combined with microneedle technology.

    Science.gov (United States)

    Jin, Xuan; Zhu, Dan Dan; Chen, Bo Zhi; Ashfaq, Mohammad; Guo, Xin Dong

    2018-03-29

    Diabetes, a metabolic disorder of glucose, is a serious chronic disease and an important public health problem. Insulin is one of the hormones for modulating blood glucose level and the products of which is indispensable for most diabetes patients. Introducing microneedles (MNs) to insulin delivery is promising to pave the way for modulating glucose level noninvasively of diabetes patients, as which born to be painless, easy to handle and no need of any power supply. In this work, we review the process of insulin delivery systems (IDSs) based on MN technology in terms of two categories: drug free MNs and drug loaded MNs. Drug free MNs include solid MNs ("poke and patch"), hollow MNs ("poke and flow") and reservoir-based swelling MNs ("poke and swell R-type"), and drug loaded MNs include coated MNs ("coat and poke"), dissolving MNs ("poke and release") and insulin incorporated swelling MNs ("poke and swell I-type"). Majority researches of MN-based IDSs have been conducted by using hollow MNs or dissolving MNs, and almost all clinical trials for MN-based IDSs have employed hollow MNs. "Poke and patch" approach dramatically increase skin permeability compared to traditional transdermal patch, but MNs fabricated from silicon or metal may leave sharp waste in the skin and cause a safety issue. "Poke and flow" approach, similar to transitional subcutaneous (SC) injection, is capable of producing faster insulin absorption and action than SC injection but may associate with blockage, leakage and low flow rate. Coated MNs are able of retaining the activity of drug, which loaded in a solid phase, for a long time, however have been relatively less studied for insulin application as the low drug dosing. "Poke and release" approach leaves no biohazardous sharp medical waste and is capable of rapid drug release. "Poke and swell R-type" can be seen as a combination of "poke and flow" and "poke and patch" approach, while "poke and swell I-type" is an approach between "coat and

  18. The importance of iteration in creative conceptual combination.

    Science.gov (United States)

    Chan, Joel; Schunn, Christian D

    2015-12-01

    Theories of creative conceptual combination hypothesize that, to generate highly creative concepts, one should attempt to combine source concepts that are very different from each other. While lab studies show a robust link between far combinations and increased novelty of concepts, empirical evidence that far combinations lead to more creative concepts (i.e., both more novel and of higher quality) is mixed. Drawing on models of the creative process, we frame conceptual combination as a divergent process, and hypothesize that iteration is necessary to convert far combinations into creative concepts. We trace conceptual genealogies of many hundreds of concepts proposed for a dozen different problems on a large-scale Web-based innovation platform, and model the effects of combination distance on creative outcomes of concepts. The results are consistent with our predictions: (1) direct effects of far combinations have a mean zero effect, and (2) indirect effects of far combinations (i.e., building on concepts that themselves build on far combinations) have more consistently positive effects. This pattern of effects is robust across problems on the platform. These findings lend clarity to theories of creative conceptual combination, and highlight the importance of iteration for generating creative concepts. Copyright © 2015 Elsevier B.V. All rights reserved.

  19. Combined research effort on aggregate road materials

    Science.gov (United States)

    Kuznetsova, Elena; Hoff, Inge; Willy Danielsen, Svein; Wigum, Børge Johannes; Fladvad, Marit; Rieksts, Karlis; Loranger, Benoit; Barbieri, Diego

    2017-04-01

    ) mechanical and c) thermal properties, and d) frost action and susceptibility. The main goal of the PhD topic N1 is to achieve better utilization of aggregate resources through adjusting the production process according to local geological conditions and construction needs. The objective of the PhD project N2 is to look at the design stage and find the way to use these aggregates anyway by changing the road's design (e.g. increasing the thickness of asphalt layer). Fine particles content will also be harder to control due to rock type variability from site to site. Thus, PhD project N3 is going to investigate the effect of the increasing of fines and their mineralogy on frost action related problems during freezing and thawing seasons. Finally, PhD project N4 is investigating how the grading and mineralogy of the crushed rock material affects the heat exchange in road's granular layers and consequently, the frost penetration depth. Combining these PhD studies we aim to create a holistic approach for a new understanding within this very complex area.

  20. Candyflipping and Other Combinations: Identifying Drug–Drug Combinations from an Online Forum

    Directory of Open Access Journals (Sweden)

    Michael Chary

    2018-04-01

    Full Text Available Novel psychoactive substances (NPS refer to synthetic compounds or derivatives of more widely known substances of abuse that have emerged over the last two decades. Case reports suggest that users combine substances to achieve desired psychotropic experiences while reducing dysphoria and unpleasant somatic effects. However, the pattern of combining NPS has not been studied on a large scale. Here, we show that posts discussing NPS describe combining nootropics with sedative-hypnotics and stimulants with plant hallucinogens or psychiatric medications. Discussions that mention sedative-hypnotics most commonly also mention hallucinogens and stimulants. We analyzed 20 years of publicly available posts from Lycaeum, an Internet forum dedicated to sharing information about psychoactive substance use. We used techniques from natural language processing and machine learning to identify NPS and correlate patterns of co-mentions of substances across posts. We found that conversations mentioning synthetic hallucinogens tended to divide into those mentioning hallucinogens derived from amphetamine and those derived from ergot. Conversations that mentioned synthetic hallucinogens tended not to mention plant hallucinogens. Conversations that mention bath salts commonly mention sedative-hypnotics or nootropics while more canonical stimulants are discussed with plant hallucinogens and psychiatric medications. All types of substances are frequently compared to MDMA, DMT, cocaine, or atropine when trying to describe their effects. Our results provide the largest analysis to date of online descriptions of patterns of polysubstance use and further demonstrate the utility of social media in learning about trends in substance use. We anticipate this work to lead to a more detailed analysis of the knowledge contained online about the patterns of usage and effects of novel psychoactive substances.

  1. Large LOCA-earthquake combination probability assessment - Load combination program. Project 1 summary report

    International Nuclear Information System (INIS)

    Lu, S.; Streit, R.D.; Chou, C.K.

    1980-01-01

    This report summarizes work performed for the U.S. Nuclear Regulatory Commission (NRC) by the Load Combination Program at the Lawrence Livermore National Laboratory to establish a technical basis for the NRC to use in reassessing its requirement that earthquake and large loss-of-coolant accident (LOCA) loads be combined in the design of nuclear power plants. A systematic probabilistic approach is used to treat the random nature of earthquake and transient loading to estimate the probability of large LOCAs that are directly and indirectly induced by earthquakes. A large LOCA is defined in this report as a double-ended guillotine break of the primary reactor coolant loop piping (the hot leg, cold leg, and crossover) of a pressurized water reactor (PWR). Unit 1 of the Zion Nuclear Power Plant, a four-loop PWR-1, is used for this study. To estimate the probability of a large LOCA directly induced by earthquakes, only fatigue crack growth resulting from the combined effects of thermal, pressure, seismic, and other cyclic loads is considered. Fatigue crack growth is simulated with a deterministic fracture mechanics model that incorporates stochastic inputs of initial crack size distribution, material properties, stress histories, and leak detection probability. Results of the simulation indicate that the probability of a double-ended guillotine break, either with or without an earthquake, is very small (on the order of 10 -12 ). The probability of a leak was found to be several orders of magnitude greater than that of a complete pipe rupture. A limited investigation involving engineering judgment of a double-ended guillotine break indirectly induced by an earthquake is also reported. (author)

  2. Hybrid drug combination: Combination of ferulic acid and metformin as anti-diabetic therapy.

    Science.gov (United States)

    Nankar, Rakesh; Prabhakar, P K; Doble, Mukesh

    2017-12-15

    Ferulic acid, an anti-oxidant phytochemical present in several dietary components, is known to produce wide range of pharmacological effects. It is approved for use in food industry as a preservative and in sports food. Previous reports from our lab have shown synergistic interaction of ferulic acid with metformin in cell lines and diabetic rats. The purpose of this review is to compile information about anti-diabetic activity of ferulic acid in in vitro and in vivo models with special emphasis on activity of ferulic acid when combined with metformin. The mechanism of synergistic interaction between ferulic acid and metformin is also proposed after carefully studying effects of these compounds on molecules involved in glucose metabolism. Scientific literature for the purpose of this review was collected using online search engines and databases such as ScienceDirect, Scopus, PubMed and Google scholar. Ferulic acid forms resonance stabilized phenoxyl radical which scavenges free radicals and reduce oxidative stress. It improves glucose and lipid profile in diabetic rats by enhancing activities of antioxidant enzymes, superoxide dismutase and catalase in the pancreatic tissue. Combining ferulic acid with metformin improves both, in vitro glucose uptake activity and in vivo hypoglycemic activity of the latter. It is possible to reduce the dose of metformin by four folds (from 50 to 12.5 mg/kg body weight) by combining it with 10 mg of ferulic acid/kg body weight in diabetic rats. Ferulic acid improves glucose uptake through PI3-K pathway whereas metformin activates AMPK pathway to improve glucose uptake. The synergistic interaction of ferulic acid and metformin is due their action on parallel pathways which are involved in glucose uptake. Due to synergistic nature of their interaction, it is possible to reduce the dose of metformin (by combining with ferulic acid) required to achieve normoglycemia. Since the dose of metformin is reduced, the dose associated side

  3. Current concepts in combination therapy for the treatment of hypertension: combined calcium channel blockers and RAAS inhibitors.

    Science.gov (United States)

    Rubio-Guerra, Alberto F; Castro-Serna, David; Barrera, Cesar I Elizalde; Ramos-Brizuela, Luz M

    2009-01-01

    Recent guidelines for the management of hypertension recommend target blood pressures hypertensive patients, or hypertensive patients do not reach the recommended treatment targets with monotherapy, making combination therapy necessary to achieve the therapeutic goal. Combination therapy with 2 or more agents is the most effective method for achieving strict blood pressure goals. Fixed-dose combination simplifies treatment, reduces costs, and improves adherence. There are many drug choices for combination therapy, but few data are available about the efficacy and safety of some specific combinations. Combination therapy of calcium antagonists and inhibitors of the renin-angiotensin-aldosterone system (RAAS) are efficacious and safe, and have been considered rational by both the JNC 7 and the 2007 European Society of Hypertension - European Society of Cardiology guidelines for the management of arterial hypertension. The aim of this review is to discuss some relevant issues about the use of combinations with calcium channel blockers and RAAS inhibitors in the treatment of hypertension.

  4. Linear and Order Statistics Combiners for Pattern Classification

    Science.gov (United States)

    Tumer, Kagan; Ghosh, Joydeep; Lau, Sonie (Technical Monitor)

    2001-01-01

    Several researchers have experimentally shown that substantial improvements can be obtained in difficult pattern recognition problems by combining or integrating the outputs of multiple classifiers. This chapter provides an analytical framework to quantify the improvements in classification results due to combining. The results apply to both linear combiners and order statistics combiners. We first show that to a first order approximation, the error rate obtained over and above the Bayes error rate, is directly proportional to the variance of the actual decision boundaries around the Bayes optimum boundary. Combining classifiers in output space reduces this variance, and hence reduces the 'added' error. If N unbiased classifiers are combined by simple averaging. the added error rate can be reduced by a factor of N if the individual errors in approximating the decision boundaries are uncorrelated. Expressions are then derived for linear combiners which are biased or correlated, and the effect of output correlations on ensemble performance is quantified. For order statistics based non-linear combiners, we derive expressions that indicate how much the median, the maximum and in general the i-th order statistic can improve classifier performance. The analysis presented here facilitates the understanding of the relationships among error rates, classifier boundary distributions, and combining in output space. Experimental results on several public domain data sets are provided to illustrate the benefits of combining and to support the analytical results.

  5. Combined methods for elliptic equations with singularities, interfaces and infinities

    CERN Document Server

    Li, Zi Cai

    1998-01-01

    In this book the author sets out to answer two important questions: 1. Which numerical methods may be combined together? 2. How can different numerical methods be matched together? In doing so the author presents a number of useful combinations, for instance, the combination of various FEMs, the combinations of FEM-FDM, REM-FEM, RGM-FDM, etc. The combined methods have many advantages over single methods: high accuracy of solutions, less CPU time, less computer storage, easy coupling with singularities as well as the complicated boundary conditions. Since coupling techniques are essential to combinations, various matching strategies among different methods are carefully discussed. The author provides the matching rules so that optimal convergence, even superconvergence, and optimal stability can be achieved, and also warns of the matching pitfalls to avoid. Audience: The book is intended for both mathematicians and engineers and may be used as text for advanced students.

  6. Biomolecular Network-Based Synergistic Drug Combination Discovery

    Directory of Open Access Journals (Sweden)

    Xiangyi Li

    2016-01-01

    Full Text Available Drug combination is a powerful and promising approach for complex disease therapy such as cancer and cardiovascular disease. However, the number of synergistic drug combinations approved by the Food and Drug Administration is very small. To bridge the gap between urgent need and low yield, researchers have constructed various models to identify synergistic drug combinations. Among these models, biomolecular network-based model is outstanding because of its ability to reflect and illustrate the relationships among drugs, disease-related genes, therapeutic targets, and disease-specific signaling pathways as a system. In this review, we analyzed and classified models for synergistic drug combination prediction in recent decade according to their respective algorithms. Besides, we collected useful resources including databases and analysis tools for synergistic drug combination prediction. It should provide a quick resource for computational biologists who work with network medicine or synergistic drug combination designing.

  7. Development and Performance of the Combined Jet Mass - LHCC Poster

    CERN Document Server

    Nelson, Michael Edward; The ATLAS collaboration

    2017-01-01

    The jet mass is a crucial discriminating variable in studies involving jet substructure.The calorimeter mass has been the canonical mass definition during the first run of ATLAS. This poster describes how the calorimeter mass can be combined with the track-assisted jet mass (which is obtained by associating inner detector tracks with calorimeter jets), to yield a new jet mass definition, the combined jet mass. The combined jet mass is constructed in such a way as to in principle, achieve a superior mass resolution over a much wider kinematic range. The process of constructing the combined mass from the calorimeter and track-assisted mass resolutions is presented, followed by a review of the performance of the combined jet mass in mass reconstruction. The combined jet mass is shown to offer significant improvements over the calorimeter and track-assisted mass approaches, and as a result it forms the new jet mass recommendation for ATLAS analyses targeting Moriond, 2017.

  8. Combinations of Genetic Variants Occurring Exclusively in Patients

    Directory of Open Access Journals (Sweden)

    Erling Mellerup

    2017-01-01

    Full Text Available In studies of polygenic disorders, scanning the genetic variants can be used to identify variant combinations. Combinations that are exclusively found in patients can be separated from those combinations occurring in control persons. Statistical analyses can be performed to determine whether the combinations that occur exclusively among patients are significantly associated with the investigated disorder. This research strategy has been applied in materials from various polygenic disorders, identifying clusters of patient-specific genetic variant combinations that are significant associated with the investigated disorders. Combinations from these clusters are found in the genomes of up to 55% of investigated patients, and are not present in the genomes of any control persons.

  9. Combination treatment for nicotine dependence: state of the science.

    Science.gov (United States)

    Ingersoll, Karen S; Cohen, Jessye

    2005-01-01

    Both nicotine replacement and sustained-release buproprion double the odds of achieving short- and moderate-term abstinence from nicotine. However, questions remain about the efficacy of combining pharmacotherapies. Our purposes were to review the evidence for (1) combined pharmacotherapy and (2) multimodal treatment combining pharmacotherapy and behavioral treatment and to recommend combinations of treatments to reduce nicotine dependence. Combining first-line pharmacotherapies with each other or with investigational drugs shows little benefit. In contrast, trials combining specific behavioral treatments with first-line pharmacotherapies show enhanced smoking cessation rates, but benefits are not seen in all populations. We recommend future directions for research, including better specification of behavioral components and further examination of the length and timing of treatment.

  10. Combination of omalizumab and bee venom immunotherapy: does it work?

    Science.gov (United States)

    Yılmaz, İnsu; Bahçecioğlu, Sakine Nazik; Türk, Murat

    2018-01-01

    Bee venom immunotherapy (b-VIT) can be combined with omalizumab therapy in order to suppress systemic reactions developing due to b-VIT itself. Omalizumab acts as a premedication and gains time for the immunotherapy to develop its immunomodulatory effects. However, the combination of omalizumab and b-VIT is not always effective enough. Herein we present a patient in whom successful immunotherapy cannot be achieved with combination of omalizumab to b-VIT.

  11. Non-compensation of the ATLAS barrel combined calorimeter prototype

    International Nuclear Information System (INIS)

    Kul'chitskij, Yu.A.; Kuz'min, M.V.

    1998-01-01

    The e / π ratio for the ATLAS Barrel Combined Calorimeter Prototype, composed from electromagnetic LArg calorimeter and hadronic Tile calorimeter was investigated. Response of Combined Calorimeter on pions and electrons in the energy region of 20-300 GeV was studied. Found e / h = 1.37 ± 0.01 ± 0.02 is in good agreement with the results from previous Combined Calorimeter tests but has more precisions

  12. LED lighting combined with solar panels in developing countries

    OpenAIRE

    Amogpai, Ater

    2011-01-01

    The aim of the work was to find out the functionality of LED lighting combined with solar panels in developing countries and to find out the availability of solar energy in different geographical locations. Another aim of the work was to understand the advantages and disadvantages of photovoltaic systems and the optimum combination of PV systems for lighting. Measurements of photovoltaic systems combined with LEDs and fluorescent lighting were conducted in an office building in Finland. ...

  13. Combined electrohydrodynamic (EHD) and vacuum freeze drying of shrimp

    International Nuclear Information System (INIS)

    Hu, Yucai; Huang, Qiang; Bai, Yaxiang

    2013-01-01

    To improve the drying qualities of shrimp, a combination of electrohydrodynamic (EHD) and vacuum freeze drying (FD) is examined. The drying rate, the shrinkage, the rehydration ratio, and the sensory properties including the color and trimness of the dried products under different drying methods (including combination drying of EHD and FD, EHD drying and FD drying) are measured. Compared with FD and EHD drying alone, the combined process consumes less drying time, and the product processed by combined drying displays lower shrinkage, higher rehydration rate and better sensory qualities.

  14. Combined two-photon microscopy and angiographic optical coherence tomography

    Science.gov (United States)

    Kim, Bumju; Wang, Tae Jun; Li, Qingyun; Nam, Jutaek; Hwang, Sekyu; Chung, Euiheon; Kim, Sungjee; Kim, Ki Hean

    2013-08-01

    A combined two-photon microscopy (TPM) and angiographic optical coherence tomography (OCT) is developed, which can provide molecular, cellular, structural, and vascular information of tissue specimens in vivo. This combined system is implemented by adding an OCT vasculature visualization method to the previous combined TPM and OCT, and then is applied to in vivo tissue imaging. Two animal models, a mouse brain cranial window model and a mouse ear cancer model, are used. Both molecular, cellular information at local regions of tissues, and structural, vascular information at relatively larger regions are visualized in the same sections. In vivo tissue microenvironments are better elucidated by the combined TPM and angiographic OCT.

  15. Products of the IGS - The Combination Process and Consistency Issues

    Science.gov (United States)

    Weber, R.; Ferland, R.; Gendt, G.

    2003-04-01

    Since 1992 the IGS generates several types of inter-dependant data products; namely: satellites ephemerides, earth rotation parameters, station coordinates/velocity, satellites/stations clock offsets, ionospheric and tropospheric delays. The first four are generally referred to as IGS core products. All those products are available to support a number of scientific activities. Many agencies contribute to the effort by providing the stations infrastructure and measurements and/or data distribution centers and/or data analysis. The Analysis Centers (AC) provide most of the products "building blocks" used to generate the IGS combined data products. These AC products are generated using independent software procedures. Those must be combined to generate the IGS data products. Simultaneous and rigorous combination of all the AC products would be difficult. A distributed approach was chosen to generate the IGS combined products, simplifying the tasks and distributing the workload, while trying to minimize the approximations. The satellites ephemerides and satellites/stations clock offsets are combined by the AC coordinator; the station coordinates/velocity and earth rotation parameters are combined within the Reference Frame Working Group (RFWG); the ionospheric and tropospheric products are generated within their respective working groups. The orbit combination is done using a weighted averaging process, where the solution from each AC provided using the SP3 format is assigned a constant weight. The clock offsets are also combined using the AC orbit weights. Originally, the ERP’s were also combined as part of the orbit combination process also using the AC orbit weights. Three types of orbit products are generated, based on the latency (ultra-rapid, rapid &final). Since 2000/02/27, the station coordinates/velocity and earth rotation parameters, provided by the ACs in the SINEX format, are combined using a rigorous least-squares adjustment with all the available

  16. Combination therapy in epilepsy: what, when, how and what not!

    Science.gov (United States)

    Mani, Jayanti

    2013-08-01

    The role of combination therapy as a treatment strategy for epilepsy is undergoing reevaluation. A growing appreciation that all seizures cannot be controlled by monotherapy and the introduction of over 14 new antiepileptic drugs (AEDs) for the adjunctive treatment in refractory epilepsy in the past twenty years has triggered an renewed interest in combination therapy. However, the experimental and clinical evidence in support of "rational polytherapy" is sparse, with only the combination of sodium valproate and lamotrigine demonstrating synergism. Robust evidence to guide clinicians on how and when to combine AEDs is lacking and current practice recommendations are largely empirical.

  17. Radix-16 Combined Division and Square Root Unit

    DEFF Research Database (Denmark)

    Nannarelli, Alberto

    2011-01-01

    Division and square root, based on the digitrecurrence algorithm, can be implemented in a combined unit. Several implementations of combined division/square root units have been presented mostly for radices 2 and 4. Here, we present a combined radix-16 unit obtained by overlapping two radix-4...... result digit selection functions, as it is normally done for division only units. The latency of the unit is reduced by retiming and low power methods are applied as well. The proposed unit is compared to a radix-4 combined division/square root unit, and to a radix-16 unit, obtained by cascading two...

  18. Computer aided system for parametric design of combination die

    Science.gov (United States)

    Naranje, Vishal G.; Hussein, H. M. A.; Kumar, S.

    2017-09-01

    In this paper, a computer aided system for parametric design of combination dies is presented. The system is developed using knowledge based system technique of artificial intelligence. The system is capable to design combination dies for production of sheet metal parts having punching and cupping operations. The system is coded in Visual Basic and interfaced with AutoCAD software. The low cost of the proposed system will help die designers of small and medium scale sheet metal industries for design of combination dies for similar type of products. The proposed system is capable to reduce design time and efforts of die designers for design of combination dies.

  19. Combination pharmacotherapy for the treatment of fibromyalgia in adults.

    Science.gov (United States)

    Thorpe, Joelle; Shum, Bonnie; Moore, R Andrew; Wiffen, Philip J; Gilron, Ian

    2018-02-19

    Fibromyalgia is a chronic widespread pain condition affecting millions of people worldwide. Current pharmacotherapies are often ineffective and poorly tolerated. Combining different agents could provide superior pain relief and possibly also fewer side effects. To assess the efficacy, safety, and tolerability of combination pharmacotherapy compared to monotherapy or placebo, or both, for the treatment of fibromyalgia pain in adults. We searched CENTRAL, MEDLINE, and Embase to September 2017. We also searched reference lists of other reviews and trials registries. Double-blind, randomised controlled trials comparing combinations of two or more drugs to placebo or other comparators, or both, for the treatment of fibromyalgia pain. From all studies, we extracted data on: participant-reported pain relief of 30% or 50% or greater; patient global impression of clinical change (PGIC) much or very much improved or very much improved; any other pain-related outcome of improvement; withdrawals (lack of efficacy, adverse events), participants experiencing any adverse event, serious adverse events, and specific adverse events (e.g. somnolence and dizziness). The primary comparison was between combination and one or all single-agent comparators. We also assessed the evidence using GRADE and created a 'Summary of findings' table. We identified 16 studies with 1474 participants. Three studies combined a non-steroidal anti-inflammatory drug (NSAID) with a benzodiazepine (306 participants); two combined amitriptyline with fluoxetine (89 participants); two combined amitriptyline with a different agent (92 participants); two combined melatonin with an antidepressant (164 participants); one combined carisoprodol, paracetamol (acetaminophen), and caffeine (58 participants); one combined tramadol and paracetamol (acetaminophen) (315 participants); one combined malic acid and magnesium (24 participants); one combined a monoamine oxidase inhibitor with 5-hydroxytryptophan (200

  20. Efficacy of combined hormonal vaginal ring in comparison to combined hormonal pills in heavy menstrual bleeding.

    Science.gov (United States)

    Dahiya, Pushpa; Dalal, Monika; Yadav, Anu; Dahiya, Krishna; Jain, Shaveta; Silan, Vijay

    2016-08-01

    To compare the efficacy, acceptability and compliance of combined hormonal vaginal ring (CVR), with combined hormonal pills (CHP) in patients with heavy menstrual bleeding (HMB). This prospective study was conducted in 50 women with HMB in age group of 25-40 years. Patients were divided in two groups of 25 each and followed for six treatment cycles. In each group, cycle comprised of three weeks of CVR (releases 15μg of EE and 120μg of the etonogestrel per day) or CHP (containing 30μgm of EE and 150μgm of LNG) use, followed by one ring or pill free week. After each cycle, patients were evaluated about the amount of blood loss and duration of bleeding by the pictoral blood assessment chart (PBAC), early bleeding (EWB), continued bleeding (CWB), intermenstrual bleeding, intended bleeding, compliance, and user acceptability. The collected data were analyzed using the Chi square test, t-test and ANOVA test. Reduction in PBAC score for CVR (70.73%) and CHP group (70.02%), duration of bleeding and incidence of EWB was comparable among the two groups. The incidence of intermenstrual bleeding was lower in CVR than in CHP group in cycle 3 and 4 with significant p value. The incidence of CWB was significantly lower and the incidence of intended bleeding pattern in CVR group was significantly higher in cycle 3, 4, 5 and 6, signifying better cycle control. Compliance was also higher in CVR (88%) than CHC (75.33% of all cycles). This trial suggests that both the CVR and CHP are very effective short-term treatments for HMB in reproductive age group. However, women had better cycle control and compliance with CVR. This may be an attractive option among the wide variety of medications used to treat HMB. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  1. In silico drug combination discovery for personalized cancer therapy.

    Science.gov (United States)

    Jeon, Minji; Kim, Sunkyu; Park, Sungjoon; Lee, Heewon; Kang, Jaewoo

    2018-03-19

    Drug combination therapy, which is considered as an alternative to single drug therapy, can potentially reduce resistance and toxicity, and have synergistic efficacy. As drug combination therapies are widely used in the clinic for hypertension, asthma, and AIDS, they have also been proposed for the treatment of cancer. However, it is difficult to select and experimentally evaluate effective combinations because not only is the number of cancer drug combinations extremely large but also the effectiveness of drug combinations varies depending on the genetic variation of cancer patients. A computational approach that prioritizes the best drug combinations considering the genetic information of a cancer patient is necessary to reduce the search space. We propose an in-silico method for personalized drug combination therapy discovery. We predict the synergy between two drugs and a cell line using genomic information, targets of drugs, and pharmacological information. We calculate and predict the synergy scores of 583 drug combinations for 31 cancer cell lines. For feature dimension reduction, we select the mutations or expression levels of the genes in cancer-related pathways. We also used various machine learning models. Extremely Randomized Trees (ERT), a tree-based ensemble model, achieved the best performance in the synergy score prediction regression task. The correlation coefficient between the synergy scores predicted by ERT and the actual observations is 0.738. To compare with an existing drug combination synergy classification model, we reformulate the problem as a binary classification problem by thresholding the synergy scores. ERT achieved an F1 score of 0.954 when synergy scores of 20 and -20 were used as the threshold, which is 8.7% higher than that obtained by the state-of-the-art baseline model. Moreover, the model correctly predicts the most synergistic combination, from approximately 100 candidate drug combinations, as the top choice for 15 out of the

  2. Joint Task Force -Guantanamo Bay, Cuba: Open or Close?

    Science.gov (United States)

    2013-03-01

    refuge on the base. U.S. Marines and Cuban militiamen then began patrolling opposite sides of the base’s 17.4 mile fence line. Today, U.S. Marines ...of the Army, Air Force, Marines , Navy, and Coast Guard. Reserve component personnel were also deployed on the mission. Military police personnel...combination cells for legal visits (not to house detainees). Camp Echo requires a guard force of approximately 40 personnel.24 Camp Iguana Camp new mission

  3. Peculiarities of Grammatical Properties in Nominal Word Combinations

    Directory of Open Access Journals (Sweden)

    Irina B. Klienkova

    2014-01-01

    Full Text Available The article examines some peculiarities if grammatical properties of nominal word combinations based on the study of German-speaking Swiss press. The accumulated experience of linguists is analyzed and certain factors influencing the choice of syntactic relations in nominal word combinations with quantitative meaning are researched. It has been established that the choice of syntactic relations in such word combinations is determined by functional style, semantics and grammatical features of nouns - first or second components in a word combination. The aforementioned factors influencing the choice of syntactic relations in quantitative nominal word combinations are studied on the material of Germanspeaking Swiss press. The research revealed a number of peculiarities. First of all, German-speaking Swiss press uses such syntactic relation as genitive subordination quite often, not only on "special occasion" and unlike its use in Germany does not produce a magniloquent, pompous impression. Secondly, it has been established that the choice of syntactic relations in word combinations of the above-mentioned type of word combinations greatly depends on the semantic meaning of the noun - the first component of the word combination - and does not always coincide with the grammatical properties in nominal combinations in Germany. Thirdly, a clear dependence of syntactic relations choice is observed. Moreover, the article highlights the importance of grammatical features of the second component. These are such features as gender, number, case accompanied by noun declension. All the afore-mentioned features help to define the type of syntactic relations, which nominal quantitative word combinations may be connected by. The results of the comparisons of grammatical properties of quantitative nominal word combinations in German and Swiss press are demonstrated in a table below.

  4. Bactericidal and antineoplastic effect of combination of norfloxacin and adriamycin.

    Science.gov (United States)

    Castelli, M; Barbieri, M L; Bertolini, A; Bossa, R; Galatulas, I

    1987-01-01

    Norfloxacin and adriamycin were tested alone and in combination for bactericidal activity against different strains of gram-negative bacteria. The antitumoral effect of a combination of norfloxacin and adriamycin was determined in mice bearing Ehrlich ascites carcinoma and in mice bearing P 388 leukemia. No interference with the antibacterial activity of norfloxacin or with the antitumoral activity of adriamycin was observed.

  5. Combined Sinh-Cosh-Gordon equation: Symmetry reductions, exact ...

    African Journals Online (AJOL)

    Combined Sinh-Cosh-Gordon equation: Symmetry reductions, exact solutions and conservation laws. ... In this paper we study the combined sinh-cosh-Gordon equation, which arises in mathematical physics and has a wide range of scientific applications that range from chemical reactions to water surface gravity waves.

  6. Combined use of Mathieu and incised plate technique (Snodgrass ...

    African Journals Online (AJOL)

    Objectives: To evaluate the results and complications after combined use of Mathieu and incised plate technique for management of distal hypospadias in older children. Patients and methods: A total of 33 patients with primary distal penile hypospadias were operated upon using the Mathieu technique combined with deep ...

  7. Assessment of a Combined Offshore Renewable Energy Resource for Ireland

    OpenAIRE

    Nolan, Gary; Ringwood, John

    2005-01-01

    This paper attempts to assess if extracting energy from a combined offshore, wind, wave and tidal resource can reduce the difficulties envisaged from integrating a large volume of a single intermittent source into the current electricity system in Ireland. The paper concludes that the use of wave power and tidal power, in combination with wind power, has significant merit.

  8. Chemoenzymatic combination of glucose oxidase with titanium silicalite -1

    DEFF Research Database (Denmark)

    Vennestrøm, Peter Nicolai Ravnborg; Taarning, Esben; Christensen, Claus H.

    2010-01-01

    Zeozymes: A proof-of-concept is presented for the chemoenzymatic combination of titanium silicalite-1 zeolite with glucose oxidase. In this combination, glucose is oxidized to gluconic acid and the H2O2 byproduct formed in situ is used for the simultaneous oxidation of chemical substrates. Both...

  9. Maxillary arch and combined incisor dimensions of Urhobos in ...

    African Journals Online (AJOL)

    The combined mesiodistal crown widths of the four maxillary permanent incisors, interpremolar and intermolar arch widths of the maxillary arch of one hundred study models (50 males and 50 females) were measured with digital Vernier Caliper. There were statistically significant gender differences in the combined ...

  10. Combined Coding And Modulation Employing Multi Phase Shift ...

    African Journals Online (AJOL)

    In this paper a technique for combining Huffman code, array code and phase modulation is proposed with a view to reduce redundancy, provide error control and simultaneously optimise on channel bandwidth. The combined scheme provides a reduction in overall complexity of the communication system as compared to a ...

  11. Effect of Combined Application of Organic and Mineral Nitrogen and ...

    African Journals Online (AJOL)

    mite

    effect of combined organic and mineral nitrogen (N) and phosphorus (P) on selected soil .... FYM and VC used in the experiment were determined and the result is depicted in Table 2. Table 2. Organic matter, N, P, .... The combined application of organic and inorganic fertilizers had significant (P<0.01) effect on the bulk ...

  12. Combining ability for maize grain yield and other agronomic ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-06-03

    Jun 3, 2009 ... can be introgressed into other promising lines in developing early maturing and high yielding varieties for cultivation in the Nigeria savannas. Key words: Zea mays L., general combining ability, specific combining ability, grain yield, Nigeria savannas. INTRODUCTION. Maize production in the southern ...

  13. Unit Commitment: A New Truncated Method of Unit Combination ...

    African Journals Online (AJOL)

    The utility industry can reduce its fuel cost by proper commitment of schedulable generating unit. In this paper, a new truncation of unit combinations is proposed which will greatly reduce the number of unit combinations to be considered for large systems. A dynamic programming optimization based digital computer ...

  14. Geometric Insight into Scalar Combination of Linear Equations

    Indian Academy of Sciences (India)

    ... Journals; Resonance – Journal of Science Education; Volume 14; Issue 11. Geometric Insight into Scalar Combination of Linear Equations. Ranjit Konkar. Classroom Volume 14 Issue 11 November 2009 pp 1092-1097 ... Keywords. Linear algebra; linear dependence; linear combination; family of lines; family of planes.

  15. 21 CFR 172.165 - Quaternary ammonium chloride combination.

    Science.gov (United States)

    2010-04-01

    ... HUMAN CONSUMPTION Food Preservatives § 172.165 Quaternary ammonium chloride combination. The food... 21 Food and Drugs 3 2010-04-01 2009-04-01 true Quaternary ammonium chloride combination. 172.165 Section 172.165 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES...

  16. Noise characterization of weighting schemes for combination of multiple exposures

    DEFF Research Database (Denmark)

    Kirk, Kristian; Andersen, Hans Jørgen

    2006-01-01

    A method for capturing high intensity dynamic range scenes with a low dynamic range camera consists in taking a series of images with different exposure settings and combining these into a single high dynamic range image. The combined image values are found by weighted averaging of values from th...

  17. Combining forecasts in short term load forecasting: Empirical ...

    Indian Academy of Sciences (India)

    We present an empirical analysis to show that combination of short term load forecasts leads to better accuracy. We also discuss other aspects of combination, i.e.,distribution of weights, effect of variation in the historical window and distribution of forecast errors. The distribution of forecast errors is analyzed in order to get a ...

  18. Drug combination may be highly effective in recurrent ovarian cancer

    Science.gov (United States)

    Significant improvement with the use of a combination drug therapy for recurrent ovarian cancer was reported at the annual meeting of the American Society of Clinical Oncology meeting in Chicago. The trial compared the activity of a combination of the dru

  19. Combining ability for maize grain yield and other agronomic ...

    African Journals Online (AJOL)

    STORAGESEVER

    2009-06-03

    Jun 3, 2009 ... the parameters except plant height, while specific combining ability (sca) and gca x year effects were significant only for grain yield. However, Tze Comp4 ... and days to flowering, with Hei 97 Tze Comp3 C4 combining very well with 3 parents (Acr 90 Pool 16-Dt,. Tze Comp4-Dmr Srbc2 and Tze Comp4 C2).

  20. Evaluation of different combinations of palm kernel cake - and cotton ...

    African Journals Online (AJOL)

    ... sole palm kernel cake based diets than those fed combinations of palm kernel cake and cottonseed cake. It is concluded that palm kernel cake alone (without any combination with cottonseed cake) is adequate as protein source in compounding protein supplements for West African Dwarf goats for profitable performance.