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Sample records for pre-race immediately post-race

  1. Factors influencing pre-race serum concentration of total carbon dioxide in Thoroughbred horses racing in California.

    Science.gov (United States)

    Cohen, N D; Stanley, S D; Arthur, R M; Wang, N

    2006-11-01

    Many racing jurisdictions monitor pre-race serum concentration of total carbon dioxide (TCO2) among racing horses. To our knowledge, factors influencing concentration of TCO2 among horses participating in racing have not been systematically evaluated and reported. To determine if characteristics of horses and racing conditions routinely recorded were significantly associated with pre-race concentration of TCO2, while accounting for and estimating effects of trainer and horse. Pre-race serum TCO2 concentrations from 5028 starts made by 2,349 horses trained by 287 trainers at 2 racetracks in California during 2005 were examined. Data regarding characteristics of starters and race conditions obtained from a commercial database were recorded for each start. Data were analysed using mixed-effects, with TCO2 concentration as the dependent variable, and trainer and horse nested within trainer as random effects. Sex, class and distance of race, frusemide administration and cloudy weather conditions were significantly (Prace TCO2 concentration. Horses that finished in the top 3 positions had values that were slightly (0.2 mmol/) but significantly (Phorses not finishing in the top 3. There were significant effects of trainer on pre-race TCO2 concentration. A variety of factors may influence pre-race TCO2 concentration in horses. Horses with better performance tend to have higher pre-race TCO2 concentrations. TCO2 concentration is associated with improved performance although the magnitude of effect was quite small. Regulatory programmes based on monitoring should consider the influence of other factors on TCO2 concentration.

  2. Myocardial response to a triathlon in male athletes evaluated by Doppler tissue imaging and biochemical parameters

    DEFF Research Database (Denmark)

    Leetmaa, T H; Dam, A; Glintborg, D

    2008-01-01

    -competition. CTnT significantly increased immediately, but decreased to within normal limits 12-24 h post-competition. Pro-BNP was significantly increased immediately post-race (27+/-21 vs 7+/-2 pmol/L pre-race, P

  3. The Effects of a 10-Kilometer Run on Muscle Strength and Power.

    Science.gov (United States)

    Gomez, Ana L.; Radzwich, Robert J.; Denegar, Craig R.; Volek, Jeff S.; Rubin, Martyn R.; Bush, Jill A.; Doan, Brandon K.; Wickham, Robbin B.; Mazzetti, Scott A.; Newton, Robert U.; French, Duncan N.; Hakkinen, Keijo; Ratamess, Nicholas A.; Kraemer, William J.

    2002-01-01

    Investigated recovery of maximal force and power following a 10-km race. Data collected on 10 healthy male distance runners pre-race, immediately post-race, and 48 hours later indicated that strength and power capabilities of these 10-km runners were for the most part restored 48 hours after the race. Only the hamstring muscle group was not fully…

  4. SALIVARY ANTIMICROBIAL PROTEIN RESPONSE TO PROLONGED RUNNING

    Directory of Open Access Journals (Sweden)

    Suzanne Schneider

    2013-01-01

    Full Text Available Prolonged exercise may compromise immunity through a reduction of salivary antimicrobial proteins (AMPs. Salivary IgA (IgA has been extensively studied, but little is known about the effect of acute, prolonged exercise on AMPs including lysozyme (Lys and lactoferrin (Lac. Objective: To determine the effect of a 50-km trail race on salivary cortisol (Cort, IgA, Lys, and Lac. Methods: 14 subjects: (6 females, 8 males completed a 50km ultramarathon. Saliva was collected pre, immediately after (post and 1.5 hrs post race ( 1.5. Results: Lac concentration was higher at 1.5 hrs post race compared to post exercise (p0.05. IgA concentration, secretion rate, and IgA/Osm were lower 1.5 hrs post compared to pre race (p<0.05. Cort concentration was higher at post compared to 1.5 (p<0.05, but was unaltered from pre race levels. Subjects finished in 7.81 ± 1.2 hrs. Saliva flow rate did not differ between time points. Saliva Osm increased at post (p<0.05 compared to pre race. Conclusions: The intensity could have been too low to alter Lys and Lac secretion rates and thus, may not be as sensitive as IgA to changes in response to prolonged running. Results expand our understanding of the mucosal immune system and may have implications for predicting illness after prolonged running.

  5. Immediate hypersensitivity to chlorhexidine.

    Science.gov (United States)

    Vu, Mi; Rajgopal Bala, Harini; Cahill, Jennifer; Toholka, Ryan; Nixon, Rosemary

    2017-06-07

    Chlorhexidine is a widely used and effective antiseptic agent. Although skin contact is usually well tolerated, it may cause both immediate and delayed hypersensitivity reactions. We report a case of immediate hypersensitivity to chlorhexidine causing both skin and respiratory symptoms following occupational exposure to chlorhexidine in a health-care worker. © 2017 The Australasian College of Dermatologists.

  6. Immediation (Cultures of Immediacy)

    DEFF Research Database (Denmark)

    Kacunko, Slavko

    2017-01-01

    The 21st century´s media praxis is increasingly characterized by the emerging “cultural principle”, “condition” or “culture of immediacy”. The processes summarized under the term immediation suggest the closure of the spatio-temporal “gap” between agencies and the media involved, resulting...... with a complex interplay of social-, security-, science- and economy-related issues. The growing interest in immediation confirms its status as a new but as yet underestimated paradigm for the arts, sciences and humanities which calls for a future-focused inquiry into the cultures of immediacy. However......, in academic and popular discourse, the focus is on documenting either (societal) challenges or (technical) solutions. This paper seeks to address this imbalance by responding to an urgent need for a systematic understanding of immediation’s major forms of appearance: 1. today´s worldwide closed...

  7. Rehabilitation with immediate denture

    Directory of Open Access Journals (Sweden)

    Mayelin de la Caridad Suárez González

    2015-06-01

    Full Text Available This is the case of a 42-year-old male patient, with past history of good health, active worker, who referred refusal to the period of tooth loss both for his own personality and work responsibility. On intra-buccal examination, his central superior and inferior incisors showed plenty of tooth decay that got most of his teeth structures; besides, on X-ray examination, horizontal bone loss is observed at third apical level of the present teeth and mobility grade III and IV, for what their extraction is indicated. From the prosthetic point of view, he was diagnosed as a superior and inferior partial edentulous patient, Kennedy class I. It was decided to rehabilitate by immediate superior and inferior total denture, performing previous multiple extractions with corrective alveoloplasty and alveolectomy. With the surgical and appliances treatment, excellent results were achieved, showing the effectiveness of this treatment.

  8. Antioxidant responses to an acute ultra-endurance exercise: impact on DNA stability and indications for an increased need for nutritive antioxidants in the early recovery phase.

    Science.gov (United States)

    Neubauer, Oliver; Reichhold, Stefanie; Nics, Lukas; Hoelzl, Christine; Valentini, Judit; Stadlmayr, Barbara; Knasmüller, Siegfried; Wagner, Karl-Heinz

    2010-10-01

    Antioxidant requirements have neither been defined for endurance nor been defined for ultra-endurance athletes. To verify whether an acute bout of ultra-endurance exercise modifies the need for nutritive antioxidants, we aimed (1) to investigate the changes of endogenous and exogenous antioxidants in response to an Ironman triathlon; (2) to particularise the relevance of antioxidant responses to the indices of oxidatively damaged blood lipids, blood cell compounds and lymphocyte DNA and (3) to examine whether potential time-points of increased susceptibility to oxidative damage are associated with alterations in the antioxidant status. Blood that was collected from forty-two well-trained male athletes 2 d pre-race, immediately post-race, and 1, 5 and 19 d later was sampled. The key findings of the present study are as follows: (1) Immediately post-race, vitamin C, α-tocopherol, and levels of the Trolox equivalent antioxidant capacity, the ferric reducing ability of plasma and the oxygen radical absorbance capacity (ORAC) assays increased significantly. Exercise-induced changes in the plasma antioxidant capacity were associated with changes in uric acid, bilirubin and vitamin C. (2) Significant inverse correlations between ORAC levels and indices of oxidatively damaged DNA immediately and 1 d post-race suggest a protective role of the acute antioxidant responses in DNA stability. (3) Significant decreases in carotenoids and γ-tocopherol 1 d post-race indicate that the antioxidant intake during the first 24 h of recovery following an acute ultra-endurance exercise requires specific attention. Furthermore, the present study illustrates the importance of a diversified and well-balanced diet to maintain a physiological antioxidant status in ultra-endurance athletes in reference to recommendations.

  9. Immediate reaction to clarithromycin.

    Science.gov (United States)

    Gangemi, S; Ricciardi, L; Fedele, R; Isola, S; Purello-D'Ambrosio, F

    2001-01-01

    We present the case of bronchospastic reaction to clarithromycin had during a drug challenge test. Personal allergic history was negative for respiratory allergies and positive for adverse drug reactions to general and regional anesthesia and to ceftriaxone. After the administration of 1/4 of therapeutic dose of clarithromycin the patient showed dyspnea, cough and bronchospasm in all the lung fields. The positivity of the test was confirmed by the negativity to the administration of placebo. The quickness and the clinical characteristic of the adverse reaction suggest a pathogenic mechanism of immediate-type hypersensitivity. On reviewing the literature we have found no reports of bronchospastic reaction to clarithromycin. Macrolides are a class of antibiotics mainly used in the last years in place of beta-lactams because of a broad spectrum of action and a low allergic power. In fact, there are few reports on allergic reactions to these molecules. Clarithromycin is one of the latest macrolides, characterised by the presence of a 14-carbon-atom lactone ring as erythromycin, active on a wide spectrum of pathogens.

  10. Associative processes in immediate recency

    National Research Council Canada - National Science Library

    Howard, Marc W; Venkatadass, Vijay; Norman, Kenneth A; Kahana, Michael J

    2007-01-01

    .... If associative processes contribute to immediate recency, as predicted by the temporal context account, the neighbors of the initial presentation of the repeated item should show enhanced recall...

  11. Immediate loading of dental implants.

    Science.gov (United States)

    Henry, P J; Liddelow, G J

    2008-06-01

    The purpose of this review is to explore the concept of immediate loading as it pertains to dental implants and the indications for clinical practice. The definition of immediate loading will be considered together with a review of the relevant literature in an attempt to provide evidence-based guidelines for successful implementation into practice. A search of electronic databases including Medline, PubMed and the Cochrane Database of Systematic Reviews was undertaken using the terms "immediate loading'', "dental implants'', "immediate function'', "early loading'', "oral implants'', "immediate restoration'' and "systematic review''. This was supplemented by handsearching in peer-reviewed journals and cross-referenced with the articles accessed. Emphasis was given to systematic reviews and controlled clinical trials. A definition of immediate loading was suggested pertinent to the realities of logistics in clinical practice with respect to application and time frame. The literature was evaluated and shown to be limited with significant shortcomings. Guidelines and recommendations for clinical protocols were suggested and illustrated by examples of case types with a minimum of 1-3 years follow-up. A list of additional references for further reading was provided. Within the limitations of this review, there is evidence to suggest that immediate loading protocols have demonstrated high implant survival rates and may be cautiously recommended for certain clinical situations. However, more high level evidence studies, preferably randomized controlled trials (RCTs), over a long time frame are required to show a clear benefit over more conventional loading protocols.

  12. Radiation Alert Immediate Disclosure Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Invocon's Radiation Alert Immediate Disclosure (RAID) system is a miniature, low-power, real-time, active radiation badge. It is designed for monitoring personnel,...

  13. [Oral rehydration immediately after appendectomy].

    Science.gov (United States)

    Azabache, W; Johanson, L

    1989-01-01

    An experimental study of 20 patients with appendicitis was carried out in order to know if after the appendectomy they tolerate the hidratation with rehidratant salts by mouth in place of endovenous hydratation. The oral hydratation was indicated in all the cases immediately after the operation and only was one failure (5%). In the 95% the oral hydratation was tolerated, 45% without gastric symptoms, 35% with mild gastric symptoms and in 15% with moderate gastric symptoms. The association of gentamycin-metronidazol administered by intramuscular and oral way respectively was used in 100% of the patients. In 80% as profilaxis and in 20% as treatment. Two cases had complication as sepsis of the wound one of the profilactic group (5.9%) and another of the treatment group. In conclusion the oral hydratation with rehydrating salts were tolerated for the patients immediately after the appendectomy.

  14. Severe immediate reaction to nabumetone.

    Science.gov (United States)

    Gonzalo-Garijo, M A; Cordobés-Duran, C; Lamilla-Yerga, A M; Moreno-Gastón, I

    2007-01-01

    Nabumetone is a nonsteroidal antiinflammatory (NSAID) prodrug that inhibits cyclooxygenase-2. It has been recommended as a safe alternative in most patients with hypersensitivity reactions to NSAIDs. Systemic reactions caused by nabumetone are not frequent. We report 2 cases of immediate systemic reactions due to nabumetone. The first case involved a 68-year-old woman who developed immediate generalized pruritus, erythema, morbilliform eruption, swollen tongue sensation, diarrhea, and hypotension after the ingestion of a single dose of nabumetone. In the second case, a 77-year-old woman developed generalized pruritus, palm erythema, colic abdominal pain, diarrhea, dizziness, tightness of the chest, dyspnea, and hypotension immediately after oral intake of nabumetone. Both patients had previously tolerated this drug. Since these episodes, they have avoided nabumetone. Skin prick tests with nabumetone (10 and 100 mg/mL) were negative. Oral challenge tests with other NSAIDs, even of the same group as nabumetone, were negative in both patients. The mechanisms responsible for the reaction were not established.

  15. Immediate Debridement and Reconstruction with

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    Hyoseob Lim

    2012-01-01

    Full Text Available Background Poststernotomy mediastinitis is a rare, but life-threatening complication,thus early diagnosis and proper management is essential for poststernotomy mediastinitis.The main treatment for mediastinitis is aggressive debridement. Several options exist forreconstruction of defects after debridement. The efficacy of immediate debridement andreconstruction with a pectoralis major muscle flap designed for the defect immediately afterthe diagnosis of poststernotomy mediastinitis is demonstrated.Methods Between September 2009 and June 2011, 6 patients were referred to the Departmentof Plastic and Reconstructive Surgery and the Department of Thoracic and CardiovascularSurgery of Ajou University Hospital for poststernotomy mediastinitis. All of the patientsunderwent extensive debridement and reconstruction with pectoralis major muscle flaps,advanced based on the pedicle of the thoracoacromial artery as soon as possible followingdiagnosis. A retrospective review of the 6 cases was performed to evaluate infection control,postoperative morbidity, and mortality.Results All patients had complete wound closures and reduced severity of infections basedon the erythrocyte sedimentation rate and C-reactive protein levels and a reduction inpoststernal fluid collection on computed tomography an average of 6 days postoperatively.A lack of growth of organisms in the wound culture was demonstrated after 3 weeks. Therewere no major wound morbidities, such as hematomas, but one minor complication requireda skin graft caused by skin flap necrosis. No patient expired after definitive surgery.Conclusions Immediate debridement and reconstruction using a pectoralis major muscle flapis a safe technique for managing infections associated with poststernotomy mediastinitis,and is associated with minimal morbidity and mortality.

  16. 12 CFR 561.24 - Immediate family.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Immediate family. 561.24 Section 561.24 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY DEFINITIONS FOR REGULATIONS AFFECTING ALL SAVINGS ASSOCIATIONS § 561.24 Immediate family. The term immediate family of any natural...

  17. Immediate Sequential Bilateral Cataract Surgery

    DEFF Research Database (Denmark)

    Kessel, Line; Andresen, Jens; Erngaard, Ditte

    2015-01-01

    The aim of the present systematic review was to examine the benefits and harms associated with immediate sequential bilateral cataract surgery (ISBCS) with specific emphasis on the rate of complications, postoperative anisometropia, and subjective visual function in order to formulate evidence......-based national Danish guidelines for cataract surgery. A systematic literature review in PubMed, Embase, and Cochrane central databases identified three randomized controlled trials that compared outcome in patients randomized to ISBCS or bilateral cataract surgery on two different dates. Meta-analyses were...... performed using the Cochrane Review Manager software. The quality of the evidence was assessed using the GRADE method (Grading of Recommendation, Assessment, Development, and Evaluation). We did not find any difference in the risk of complications or visual outcome in patients randomized to ISBCS or surgery...

  18. Zegerid--immediate-release omeprazole.

    Science.gov (United States)

    2005-04-11

    The FDA has approved marketing of Zegerid powder for oral suspension (Santarus), an immediate-release formulation of the proton-pump inhibitor (PPI) omeprazole (Prilosec, and others). All other oral PPIs are delayed-release, enteric-coated formulations designed to prevent degradation of the drug by gastric acid. Each 20- or 40-mg packet of Zegerid contains 1680 mg sodium bicarbonate, which protects the drug from gastric acid degradation. A dose of Zegerid contains 460 mg of sodium, which may be excessive for some patients. Zegerid is the first oral PPI to be approved by the FDA for reduction of risk of upper GI bleeding in critically ill patients. The drug may be useful for patients who are unable to swallow and have nasogastric (NG) tubes in place. Zegerid cost $70.00 for 14 days' treatment, compared to less than $10 for 14 tablets of Prilosec OTC.

  19. Osseointegration of Immediate Transalveolar Implants

    Directory of Open Access Journals (Sweden)

    Yoel González Beriau

    2016-02-01

    Full Text Available Background: osseointegration is critical to start prosthetic rehabilitation. Objective: to describe osseointegration of immediate transalveolar implants. Methods: a prospective case series study was conducted from January 2012 to December 2013. It included all patients (75 patients with 79 implants who attended the Prosthodontics service. Age, sex, osseointegration, cause of tooth loss, region of the implant, specific tooth, bone level and keratinized gingiva around the implant, were the variables studied. Frequency distribution and statistical analysis were used for data analysis. Results: females and patients aged 31 to 45 years predominated. Osseointegration was observed in 97.4% of the implants. Nearly all implants were placed in the premaxilla and posterior maxilla, specifically in the first bicuspids. In most patients, osseointegration with bone formation occurred at the implant collar and in the presence of completely keratinized tissue, with a statistically significant association between the two variables. Conclusion: rehabilitation treatment with this type of implant led to successful osseointegration in most cases studied.

  20. Immediate response to cigarette smoke

    Energy Technology Data Exchange (ETDEWEB)

    Rees, P.J.; Chowienczyk, P.J.; Clark, T.J.

    1982-06-01

    Using an automated method of calculating airways resistance in the body plethysmograph, we have investigated changes occurring immediately after inhalation of cigarette smoke. Decreases in specific conductance occurred by the time of the first measurement seven or eight seconds after exposure to single inhalations of cigarette smoke in 12 smokers and 12 non-smokers. Less than half of the initial change was present 40 seconds after the inhalation. Initial responses were greater in the non-smokers. Responses recurred with repeated inhalations in smokers and non-smokers. Prior administration of salbutamol and ipratropium bromide significantly inhibited the response and this inhibition appeared to be greater in non-smokers. Sodium cromoglycate inhaled as a dry powder had no effect on the response.

  1. Rehearsal in immediate serial recall.

    Science.gov (United States)

    Tan, Lydia; Ward, Geoff

    2008-06-01

    We report for the first time overt rehearsal data in immediate serial recall (ISR) undertaken at three presentation rates (1, 2.5, and 5 sec/word). Two groups of participants saw lists of six words for ISR and were required either to engage in overt rehearsal or to remain silent after reading aloud the word list during its presentation. Typical ISR serial position effects were obtained for both groups, and recall increased with slower rates. When participants rehearsed, they tended to do so in a cumulative forward order up to Serial Position 4, after which the amount of rehearsal decreased substantially. There were similarities between rehearsal and recall data: Both broke down toward the end of longer sequences, and there were strong positive correlations between the maximum sequence of participants' rehearsals and their ISR performance. We interpret these data as suggesting that similar mechanisms underpin both rehearsal and recall in ISR.

  2. Immediate error correction process following sleep deprivation

    National Research Council Canada - National Science Library

    HSIEH, SHULAN; CHENG, I‐CHEN; TSAI, LING‐LING

    2007-01-01

    ...) participated in this study. Participants performed a modified letter flanker task and were instructed to make immediate error corrections on detecting performance errors. Event‐related potentials (ERPs...

  3. Immediate Implants: Clinical Guidelines for Esthetic Outcomes

    Directory of Open Access Journals (Sweden)

    Mohammad A. Javaid

    2016-06-01

    Full Text Available Research has shown that tooth loss results in morphological changes in alveolar ridge that may influence the subsequent implant placement. Immediate implant placement was introduced as a possible means to limit bone resorption and reduce the number of surgical procedures following tooth extraction. Histological and clinical evidence from human clinical studies showing efficacy of immediate implants has come to light over the last decade or so. However, immediate implant placement is a challenging surgical procedure and requires proper case selection and surgical technique. Furthermore, there appears to be a lack of clinical guidelines for immediate implant placement case selection. Therefore, the aim of this mini-review is to analyze critical evidence from human studies in order to establish clinical guidelines which may help clinicians in case selection when considering immediate implant placement protocol.

  4. Immediate start of hormonal contraceptives for contraception.

    Science.gov (United States)

    Lopez, Laureen M; Newmann, Sara J; Grimes, David A; Nanda, Kavita; Schulz, Kenneth F

    2012-12-12

    Health care providers often tell women to wait until the next menses to begin hormonal contraception. The intent is to avoid contraceptive use during an undetected pregnancy. An alternative is to start hormonal contraception immediately with back-up birth control for the first seven days. Immediate initiation was introduced with combined oral contraceptives (COCs), and has expanded to other hormonal contraceptives. At the time of the initial review, how immediate start compared to conventional menses-dependent start was unclear regarding effectiveness, continuation, and acceptability. The immediate-start approach may improve women's access to, and continuation of, hormonal contraception. This review examined randomized controlled trials (RCTs) of immediate-start hormonal contraception for differences in effectiveness, continuation, and acceptability. In August 2012, we searched MEDLINE, CENTRAL, POPLINE, LILACS, ClinicalTrials.gov, and ICTRP for trials of immediate-start hormonal contraceptives. We contacted researchers to find other studies. Earlier searches also included EMBASE. We included RCTs that compared immediate start to conventional start of hormonal contraception. Also included were trials that compared immediate start of different hormonal contraceptive methods with each other. Data were abstracted by two authors and entered into RevMan. The Peto odds ratio (OR) with 95% confidence interval (CI) was calculated. Five studies were included. No new eligible studies have been found since the review was initially conducted. Method discontinuation was similar between groups in all trials. Bleeding patterns and side effects were similar in trials that compared immediate with conventional start. In a study of depot medroxyprogesterone acetate (DMPA), immediate start of DMPA showed fewer pregnancies than a 'bridge' method before DMPA (OR 0.36; 95% CI 0.16 to 0.84). Further, more women in the immediate-DMPA group were very satisfied versus those with a 'bridge

  5. Immediate Intrauterine Device Insertion Following Surgical Abortion.

    Science.gov (United States)

    Patil, Eva; Bednarek, Paula H

    2015-12-01

    Placement of an intrauterine device (IUD) immediately after a first or second trimester surgical abortion is safe and convenient and decreases the risk of repeat unintended pregnancy. Immediate postabortion IUD placement is not recommended in the setting of postprocedure hemorrhage, uterine perforation, infection, or hematometra. Otherwise, there are few contraindications to IUD placement following surgical abortion. Sexually transmitted infection screening should follow US Centers for Disease Control and Prevention guidelines. No additional antibiotics are needed beyond those used for the abortion. Placing immediate postabortion IUDs makes highly-effective long-acting reversible contraception more accessible to women.

  6. Immediate loading of immediate mandibular implants with a full-arch fixed prosthesis: a preliminary study.

    Science.gov (United States)

    Peñarrocha, Miguel; Boronat, Araceli; Garcia, Berta

    2009-06-01

    To determine the survival of immediate dental implants with immediate loading in the partially edentulous mandible, by use of a full-arch screw-retained provisional restoration. Patients who were partially edentulous in the mandible with indications for extraction of the remaining teeth and with a minimum follow-up of 12 months after implant placement were included in the study. They were treated in chronologic order by the insertion of 6 Defcon dental implants (Impladent, Sentmenat, Spain) subjected to immediate loading (4 interforaminal and 2 posterior placements). Implants with a minimum primary stability of 60 implant stability quotient were loaded. All resin screw-retained prostheses were inserted and loaded with fully functional occlusion within 24 hours of implant placement. Eleven patients were treated with immediate implants, although 2 patients were excluded from the study for having an implant stability quotient value below 60 in at least one of the implants after surgery and did not undergo restoration with immediate loading. Fifty-four implants were placed in 9 partially edentulous patients with immediate loading with a full-arch screw-fixed prosthesis. The patients wore this provisional prosthesis during the healing period (2 months) without complication and with a high level of comfort. The survival rate of the implants was 100% at 12 months of follow-up. Immediate mandibular loading with immediate full-arch implant-supported and screw-retained restorations is a viable treatment alternative, yielding a 100% success rate in this small series of patients.

  7. Immediate implant loading: A case report

    OpenAIRE

    Dhamankar, Dilip; Gupta, Arun R.; Mahadevan, Janani

    2010-01-01

    Dental implants have long provided an excellent treatment option to restore edentulous spaces. Successful formation of a direct bone to implant interface is the goal in implant therapy. Immediate loading is an alternative to two stage surgical procedure. Improved surgical instrumentation implants design, and surface topography changes the concept of two stages surgical to one stage surgical procedure.

  8. Immediate retransplantation for pancreas allograft thrombosis.

    Science.gov (United States)

    Hollinger, E F; Powelson, J A; Mangus, R S; Kazimi, M M; Taber, T E; Goble, M L; Fridell, J A

    2009-04-01

    Early pancreas allograft failure most commonly results from thrombosis and requires immediate allograft pancreatectomy. Optimal timing for retransplantation remains undefined. Immediate retransplantation facilitates reuse of the same anatomic site before extensive adhesions have formed. Some studies suggest that early retransplantation is associated with a higher incidence of graft loss. This study is a retrospective review of immediate pancreas retransplants performed at a single center. All cases of pancreas allograft loss within 2 weeks were examined. Of 228 pancreas transplants, 12 grafts were lost within 2 weeks of surgery. Eleven of these underwent allograft pancreatectomy for thrombosis. One suffered anoxic brain injury and was not a retransplantation candidate, one was retransplanted at 3.5 months and nine patients underwent retransplantation 1-16 days following the original transplant. Of the nine early retransplants, one pancreas was lost to heparin-induced thrombocytopenia, one recipient died with function at 2.9 years and the other grafts continue to function at 76-1137 days (mean 572 days). One-year graft survival for early retransplantation was 89% compared to 91% for all pancreas transplants at our center. Immediate retransplantation following pancreatic graft thrombosis restores durable allograft function with outcomes comparable to first-time pancreas transplantation.

  9. Rehearsal and recall in immediate memory

    NARCIS (Netherlands)

    Sanders, A.F.

    1961-01-01

    Experiments on the influence of rehearsal on the retention and recoil of digit combinations are described, from the results of which it appears that a rehearsal period facilitates recall by producing a transition from immediate to permanent memory. It further seems that some parts of the material pr

  10. The oncological implications of immediate breast reconstruction.

    NARCIS (Netherlands)

    Knottenbelt, A.; Spauwen, P.H.M.; Wobbes, Th.

    2004-01-01

    AIMS: The timing of breast reconstruction following mastectomy has been an area of contention. The purpose of this study was to report the oncologic safety of mastectomy and immediate breast reconstruction, primarily with a tissue expander. METHODS: We offered 54 patients (58 reconstructions) an

  11. Immediate-type hypersensitivity to polyethylene glycols

    DEFF Research Database (Denmark)

    Wenande, E; Garvey, L H

    2016-01-01

    Polyethylene glycols (PEGs) or macrogols are polyether compounds widely used in medical and household products. Although generally considered biologically inert, cases of mild to life-threatening immediate-type PEG hypersensitivity are reported with increasing frequency. Nevertheless, awareness...... of PEG's allergenic potential remains low, due to a general lack of suspicion towards excipients and insufficient product labelling. Information on immediate-type reactions to PEG is limited to anecdotal reports, and the potential for PEG sensitization and cross-sensitization to PEGylated drugs...... to a range of unrelated products in hospital and at home. Increased awareness of PEG prevalence, PEG hypersensitivity, and improved access to PEG allergy testing, should facilitate earlier diagnosis and reduce the risk of inadvertent re-exposure. This first comprehensive review provides practical information...

  12. Selective immediate hypersensitivity reactions to NSAIDs.

    Science.gov (United States)

    Canto, Maria Gabriela; Andreu, Isabel; Fernandez, Javier; Blanca, Miguel

    2009-08-01

    Selective immediate reactions to NSAIDs imply that patients develop a urticarial/anaphylactic response to a single drug with good tolerance to other compounds. No systematic review of these reactions has yet been made. With the increase in consumption of NSAIDs, these have become one of the most common drugs inducing hypersensitivity reactions. Although cross-intolerance reactions are the most common, a significant proportion is selective responses. As specific IgE antibodies are not always found, there is only indirect evidence supporting an IgE-mediated mechanism in selective NSAID reactors. Selective immediate reactions to NSAIDs must be considered when a patient develops urticaria or anaphylaxis after intake of one drug with good tolerance to drugs from other groups or even a drug from the same group with a slightly different chemical structure. Further research is required to identify the antigenic determinant structures recognized.

  13. Reinforcement Learning by Comparing Immediate Reward

    CERN Document Server

    Pandey, Punit; Kumar, Shishir

    2010-01-01

    This paper introduces an approach to Reinforcement Learning Algorithm by comparing their immediate rewards using a variation of Q-Learning algorithm. Unlike the conventional Q-Learning, the proposed algorithm compares current reward with immediate reward of past move and work accordingly. Relative reward based Q-learning is an approach towards interactive learning. Q-Learning is a model free reinforcement learning method that used to learn the agents. It is observed that under normal circumstances algorithm take more episodes to reach optimal Q-value due to its normal reward or sometime negative reward. In this new form of algorithm agents select only those actions which have a higher immediate reward signal in comparison to previous one. The contribution of this article is the presentation of new Q-Learning Algorithm in order to maximize the performance of algorithm and reduce the number of episode required to reach optimal Q-value. Effectiveness of proposed algorithm is simulated in a 20 x20 Grid world dete...

  14. [Fetal pain: immediate and long term consequences].

    Science.gov (United States)

    Houfflin Debarge, Véronique; Dutriez, Isabelle; Pusniak, Benoit; Delarue, Eléonore; Storme, Laurent

    2010-06-01

    Several situations are potentially painful for fetuses, such as malformations and invasive procedures. Nociceptive pathways are known to be functional at 26 weeks. Even if it is not possible to evaluate the fetal experience of pain, it is essential to examine its immediate and long-term consequences. As early as the beginning of the second trimester, hemodynamic and hormonal responses are observed following fetal nociceptive stimulation, In experimental studies, long-term changes have been noted in the corticotrop axis, subsequent responses to pain, and behavior after perinatal nociceptive stimulation.

  15. [Immediate breast reconstruction for breast cancer].

    Science.gov (United States)

    Yamamoto, Daigo; Tanaka, Yoshihito; Tsubota, Yu; Sueoka, Noriko; Endo, Kayoko; Ogura, Tsunetaka; Nagumo, Yoshinori; Kwon, A-Hon

    2014-11-01

    We performed immediate breast reconstruction after nipple-sparing mastectomy or skin-sparing mastectomy and evaluated the reconstruction procedure, cosmesis, and complications. Among the 30 patients included in the study, 6 received latissimus dorsi flaps, 1 received a transverse rectus abdominis myocutaneous flap, 7 received deep inferior epigastric perforator flaps, 1 received an implant, and 15 received tissue expanders. In addition, the results were excellent in 25 patients, good in 3 patients, and poor in 2 patients. As the number of patients with breast cancer is increasing, the demand for breast reconstruction will increase. Therefore, it is essential to choose an appropriate method of breast reconstruction for each case.

  16. The importance of immediately loaded immediate post-extractive implants in esthetical rehabilitation: case series.

    Science.gov (United States)

    Danza, M; Fanali, S; Quaranta, A; Vozza, I

    2010-04-01

    The aim of this paper was to estimate, in a retrospective way, integration of hard and soft tissues in immediately loaded immediate postextractive implants. Benefits of this technique could be: single stage surgery, biological saving of tissues, aesthetic management of edentulism, good integration of both hard and soft tissues. Immediate loading of a postextractive implant seems also to produce a positive effect on the quality of perimplant soft tissues. The implants used in the present study have some advantages such as high auto-threading and auto-tapping ability, progressive increase of the thickness of the threads, at the apical and coronal level. All these features have helped to obtain a high primary stability.

  17. 29 CFR 780.307 - Exemption for employer's immediate family.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Exemption for employer's immediate family. 780.307 Section... 13(a)(6) Statutory Provisions § 780.307 Exemption for employer's immediate family. Section 13(a)(6)(B... other member of the employer's immediate family.” The requirements of this exemption, evident from the...

  18. 19 CFR 142.25 - Discontinuance of immediate delivery privileges.

    Science.gov (United States)

    2010-04-01

    ... SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) ENTRY PROCESS Special Permit for Immediate Delivery § 142.25 Discontinuance of immediate delivery privileges. (a) Authority of port director. The port director... 19 Customs Duties 2 2010-04-01 2010-04-01 false Discontinuance of immediate delivery privileges...

  19. 29 CFR 780.308 - Definition of immediate family.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Definition of immediate family. 780.308 Section 780.308... 13(a)(6) Statutory Provisions § 780.308 Definition of immediate family. The Act does not define the scope of “immediate family.” Whether an individual other than a parent, spouse or child will be...

  20. Immediate lexical integration of novel word forms

    Science.gov (United States)

    Kapnoula, Efthymia C.; McMurray, Bob

    2014-01-01

    It is well known that familiar words inhibit each other during spoken word recognition. However, we do not know how and under what circumstances newly learned words become integrated with the lexicon in order to engage in this competition. Previous work on word learning has highlighted the importance of offline consolidation (Gaskell & Dumay, 2003) and meaning (Leach & Samuel, 2007) to establish this integration. In two experiments we test the necessity of these factors by examining the inhibition between newly learned items and familiar words immediately after learning. Participants learned a set of nonwords without meanings in active (Exp 1) or passive (Exp 2) exposure paradigms. After training, participants performed a visual world paradigm task to assess inhibition from these newly learned items. An analysis of participants’ fixations suggested that the newly learned words were able to engage in competition with known words without any consolidation. PMID:25460382

  1. Output order in immediate serial recall.

    Science.gov (United States)

    Tan, Lydia; Ward, Geoff

    2007-07-01

    In two experiments, we examined the effect of output order in immediate serial recall (ISR). In Experiment 1, three groups of participants saw lists of eight words and wrote down the words in the rows corresponding to their serial positions in an eight-row response grid. One group was precued to respond in forward order, a second group was precued to respond in any order, and a third group was postcued for response order. There were significant effects of output order, but not of cue type. Relative to the forward output order, the free output order led to enhanced recency and diminished primacy, with superior performance for words output early in recall. These results were replicated in Experiment 2 using six-item lists, which further suggests that output order plays an important role in the primacy effect in ISR and that the recency items are most highly accessible at recall.

  2. Digital immediate dentures treatment: A clinical report of two patients.

    Science.gov (United States)

    Neumeier, Toni Tien; Neumeier, Harold

    2016-09-01

    The use of computer-aided engineering (CAE) and computer-aided design and computer-aided manufacturing (CAD-CAM) technology to fabricate complete dentures was introduced in 2011. Clinical procedures for digital immediate dentures can be identical to those for conventional immediate dentures and can be simplified by leaving all remaining dentition until the time of extraction and denture placement. Through the digital process, a single digital design and a definitive digital record are created which can be used to fabricate the immediate digital denture and surgical reduction guide for alveoloplasty. Digital immediate dentures can be relined using the same process as for conventional dentures. The definitive digital dentures can be fabricated with a reline impression and new centric relation record, using the existing digital immediate denture without additional clinical procedures. Providing patients with digital immediate dentures is a viable trend.

  3. Immediate CAD/ CAM Custom Fabricated Dental Implants

    Directory of Open Access Journals (Sweden)

    Jafar Kolahi

    2010-11-01

    Full Text Available Introduction: There will almost always be gaps between cylin-drical or screw shaped prefabricated implant surface and funnel-shaped tooth socket when an implant is placed immediately after tooth extraction. Hence expensive and difficult bone grafting is re-quired. A custom fabricated implant will be a pragmatic solution for this limitation.The hypothesis: First step following extraction of a tooth is data capture or scanning via a 3D scan method e.g. coordinate measuring machine or non-contact laser scanners such as triangulation range finder. Second step is reconstruction or modeling via editable CAD (computer-aided design model, allowing us to add retentive holes and correction of implant angle. Third step is fabrication via CAM (computer aided manufacturing followed by plasma cleaning process. Fourth step is insertion of the CAD/CAM custom fabricated one-stage implant in the fresh tooth socket. Optimal time for this step is 24-48 hours after extraction. The custom fabricated implant should not load 3-4 months. Usage of chlorhexidine mouth-rinse or chewing gum twice daily for 2 weeks and, in some cases oral antibiotic is recommended. Evaluation of the hypothesis: Contemporary dental implant system faced with several clinical and anatomical limitations such is low sinuses or nerve bundles. Complex and expensive surgical procedures such as nerve repositioning and sinus lift are frequently required. With custom fabricated implant we can overcome several of these limitations because insertion of custom fabricated implant will perform before alveolar bone recession.

  4. Microwave Tissue Soldering for Immediate Wound Closure

    Science.gov (United States)

    Arndt, G. Dickey; Ngo, Phong H.; Phan, Chau T.; Byerly, Diane; Dusl, John; Sognier, Marguerite A.; Carl, James

    2011-01-01

    A novel approach for the immediate sealing of traumatic wounds is under development. A portable microwave generator and handheld antenna are used to seal wounds, binding the edges of the wound together using a biodegradable protein sealant or solder. This method could be used for repairing wounds in emergency settings by restoring the wound surface to its original strength within minutes. This technique could also be utilized for surgical purposes involving solid visceral organs (i.e., liver, spleen, and kidney) that currently do not respond well to ordinary surgical procedures. A miniaturized microwave generator and a handheld antenna are used to deliver microwave energy to the protein solder, which is applied to the wound. The antenna can be of several alternative designs optimized for placement either in contact with or in proximity to the protein solder covering the wound. In either case, optimization of the design includes the matching of impedances to maximize the energy delivered to the protein solder and wound at a chosen frequency. For certain applications, an antenna could be designed that would emit power only when it is in direct contact with the wound. The optimum frequency or frequencies for a specific application would depend on the required depth of penetration of the microwave energy. In fact, a computational simulation for each specific application could be performed, which would then match the characteristics of the antenna with the protein solder and tissue to best effect wound closure. An additional area of interest with potential benefit that remains to be validated is whether microwave energy can effectively kill bacteria in and around the wound. Thus, this may be an efficient method for simultaneously sterilizing and closing wounds.

  5. Immediate bleeding complications in dental implants: a systematic review

    OpenAIRE

    Balaguer Martí, José Carlos; Peñarrocha Oltra, David; Balaguer Martínez, José; Peñarrocha Diago, Miguel

    2015-01-01

    Objective: A review is made of the immediate or immediate postoperative bleeding complications in dental implants, with a view to identifying the areas of greatest bleeding risk, the causes of bleeding, the length of the implants associated with bleeding, the most frequently implicated blood vessels, and the treatments used to resolve these complications. Material and Methods: A Medline (PubMed) and Embase search was made of articles on immediate bleeding complications in dental implants publ...

  6. Human Cytomegalovirus Immediate Early Interaction with Host Nuclear Structures: Definition of an Immediate Transcript Environment

    Science.gov (United States)

    Ishov, Alexander M.; Stenberg, Richard M.; Maul, Gerd G.

    1997-01-01

    The development of an induced transcript environment was investigated at the supramolecular level through comparative localization of the human cytomegalovirus immediate early (IE) transcripts and specific nuclear domains shortly after infection. Compact aggregates of IE transcripts form only adjacent to nuclear domain 10 (ND10), and the viral protein IE86 accumulates exclusively juxtaposed to the subpopulation of ND10 with transcripts. The stream of transcripts is funneled from ND10 into the spliceosome assembly factor SC35 domain through the accumulation of IE86 protein, which recruits some components of the basal transcription machinery. Concomitantly the IE72 protein binds to ND10 and later disperses them. The domain containing the zinc finger region of IE72 is essential for this dispersal. Positional analysis of proteins IE86 and IE72, IE transcripts, ND10, the spliceosome assembly factor SC35, and basal transcription factors defines spatially and temporally an immediate transcript environment, the basic components of which exist in the cell before viral infection, providing the structural environment for the virus to usurp. PMID:9214377

  7. Immediate Postoperative Oral Nutrition Following Esophagectomy : A Multicenter Clinical Trial

    NARCIS (Netherlands)

    Weijs, Teus J.; Berkelmans, Gijs H. K.; Nieuwenhuijzen, Grard A. P.; Dolmans, Annemarie C. P.; Kouwenhoven, Ewout A.; Rosman, Camiel; Ruurda, Jelle P.; van Workum, Frans; van Det, J.; Silva Corten, Luis C.; van Hillegersberg, Richard; Luyer, Misha D. P.

    2016-01-01

    Background Immediate start of oral intake is beneficial following colorectal surgery. However, following esophagectomy the safety and feasibility of immediate oral intake is unclear, thus these patients are still kept nil by mouth. This study therefore aimed to determine the feasibility and safety o

  8. [Immediate cooling with water: emergency treatment of burns].

    Science.gov (United States)

    Latarjet, J

    1990-01-01

    Experimental data have demonstrated that prolonged immediate cooling with cold water is the best first-aid treatment for burn injuries. However in France, this treatment is rarely applied; instead old, inefficient and aggravating methods are still very popular. Pediatricians must help to change this practice by recommending immediate cold water treatment for burns in children.

  9. Implementing Immediate Postpartum Long-Acting Reversible Contraception Programs.

    Science.gov (United States)

    Hofler, Lisa G; Cordes, Sarah; Cwiak, Carrie A; Goedken, Peggy; Jamieson, Denise J; Kottke, Melissa

    2017-01-01

    To understand the most important steps required to implement immediate postpartum long-acting reversible contraception (LARC) programs in different Georgia hospitals and the barriers to implementing such a program. This was a qualitative study. We interviewed 32 key personnel from 10 Georgia hospitals working to establish immediate postpartum LARC programs. Data were analyzed using directed qualitative content analysis principles. We used the Stages of Implementation to organize participant-identified key steps for immediate postpartum LARC into an implementation guide. We compared this guide to hospitals' implementation experiences. At the completion of the study, LARC was available for immediate postpartum placement at 7 of 10 study hospitals. Participants identified common themes for the implementation experience: team member identification and ongoing communication, payer preparedness challenges, interdependent department-specific tasks, and piloting with continuing improvements. Participants expressed a need for anticipatory guidance throughout the process. Key first steps to immediate postpartum LARC program implementation were identifying project champions, creating an implementation team that included all relevant departments, obtaining financial reassurance, and ensuring hospital administration awareness of the project. Potential barriers included lack of knowledge about immediate postpartum LARC, financial concerns, and competing clinical and administrative priorities. Hospitals that were successful at implementing immediate postpartum LARC programs did so by prioritizing clear communication and multidisciplinary teamwork. Although the implementation guide reflects a comprehensive assessment of the steps to implementing immediate postpartum LARC programs, not all hospitals required every step to succeed. Hospital teams report that implementing immediate postpartum LARC programs involves multiple departments and a number of important steps to consider. A

  10. Immediate placement of dental implants in the mandible

    Directory of Open Access Journals (Sweden)

    Gurkar Haraswarupa Puttaraju

    2013-01-01

    Full Text Available This case describes extraction of teeth in the mandibular arch, i.e., 41 42 43 44 45 51 52 53 54 55 56 57 58 (grade two mobility, followed by immediate placement of four dental implants (3i biomet, two in the 45 55 region and two dental implants in 12 21 region. A prefabricated provisional mandibular denture was immediately placed. The purpose of immediate placement was to aid the patient resume his professional duties the next day itself along with esthetic and functional comfort, psychological well-being and most importantly preserving the remaining tissue in a healthy condition.

  11. Writing Tasks and Immediate Auditory Memory in Peruvian Schoolchildren

    Directory of Open Access Journals (Sweden)

    José Luis Ventura-León

    2017-04-01

    Full Text Available The purpose of the study is determine the relationship between a group of writing tasks and the immediate auditory memory, as well as to establish differences according to sex and level of study. Two hundred and three schoolchildren of fifth and sixth of elementary education from Lima (Peru participated, they were selected by a non-probabilistic sample. The Immediate Auditory Memory Test and the Battery for Evaluation of Writing Processes (known in Spanish as PROESC were used. Central tendency measures were used for descriptive analysis. We employed the Mann-Whitney U test, Spearman Rho test and probability of superiority as effect size measurement for the inferential analysis. The results indicated a moderate direct and significant correlation between writing tasks and immediate auditory memory in general way and low correlations between dimensions. Finally, it showed that the differences in immediate auditory memory and writing tasks according to sex and level of study does not have practical significance.

  12. Immediate tool incorporation processes determine human motor planning with tools

    National Research Council Canada - National Science Library

    Ganesh, G; Yoshioka, T; Osu, R; Ikegami, T

    2014-01-01

    .... However tool incorporation, evident as extensions in our body representation and peri-personal space, has been observed predominantly after extended tool exposures and does not explain our immediate...

  13. 2. A Study to Assess Problems Encountered by Immediate Family ...

    African Journals Online (AJOL)

    Esem

    the problems experienced by immediate families in caring for ... between monthly income and experiencing financial problems by the ... enable them have an improved quality of life. ..... developing liaison services to meet the health needs.

  14. Immediate placement of endosseous implants into the extraction sockets

    Directory of Open Access Journals (Sweden)

    Vijay Ebenezer

    2015-01-01

    Full Text Available Implant by definition "means any object or material, such as an alloplastic substance or other tissue, which is partial or completely inserted into the body for therapeutic, diagnostic, prosthetic, or experimental purpose." The placement of a dental implant in an extraction socket at the time of extraction or explantation is known as immediate implant placement whereas delayed placement of implant signifies the implant placement in edentulous areas where healing has completed with new bone formation after the loss of tooth/teeth. Recent idea goes by "why late when it can be done immediately." There are several advantages of immediate placement of implants, and lots of studies have been done. In this article, the advantages and disadvantages of immediate versus delayed placement of implants have been reviewed.

  15. Immediate and Sustained Effects of a Study Skills Training ...

    African Journals Online (AJOL)

    Immediate and Sustained Effects of a Study Skills Training Programme on Students' Scores in Biology. ... African Journal for the Psychological Study of Social Issues. Journal Home ... This study used a matched two-group post-test design.

  16. Periodic points in the intersection of immediate attracting basins boundaries

    OpenAIRE

    Rossetti, Bastien

    2014-01-01

    We give sufficient conditions under which the set of eventually periodic points in the intersection of immediate attracting basins boundaries is non-empty. We give other conditions under which this set is dense in the intersection.

  17. Premature rupture of membranes at term: immediate induction of ...

    African Journals Online (AJOL)

    Premature rupture of membranes at term: immediate induction of labor versus expectant ... AFRICAN JOURNALS ONLINE (AJOL) · Journals · Advanced Search · USING ... Methods: One hundred and fifty two women with PROM at term were ...

  18. [The immediate interpretation for fine-needle aspiration cytology].

    Science.gov (United States)

    Chang, M C; Ho, W L

    1993-11-01

    From December 1990 to November 1992, 2005 cases of immediate interpretation for fine-needle aspiration (FNA) cytology were performed, of which 727 cases were confirmed by surgical pathology. A mobile cytologic laboratory (a cart loaded with a dual viewing microscope, Liu's staining solutions, hair dryer, and slides) can be moved to the Out-patient Department, wards and Computed Tomography room, where clinicians perform aspiration and pathologists read smears. Immediate verbal diagnoses are documented to patients' charts and listed in cytopathologic files. Immediate interpretation in this entire series yielded a sensitivity 92.5%; specificity, 98.1%; false-positive rate, 1.1%; false-negative rate, 3.2%; positive predictive value (PV), 97.3%; negative PV, 94.7% and efficiency, 95.7%. The cause of false-negative results in the 23 cases probably came from the hesitation in making an immediate diagnosis. Most of these cases were malignant lymphoma or breast carcinoma. The roles of immediate cytodiagnosis are (1) to decrease the inadequate rate of FNA specimens; (2) to render preliminary diagnosis for clinicians to make decisions; (3) to provide on-site teaching material for both clinicians and pathology residents to better understand clinicopathological correlations; (4) to act as the initial diagnostic procedure in the evaluation of a superficial palpable mass. This study shows that immediate interpretation for FNA cytology is a simple, rapid, accurate and noninvasive diagnostic procedure that can be routinely used for superficial palpable masses.

  19. New clinical technique for fabrication immediate partial denture

    Directory of Open Access Journals (Sweden)

    Abdulsalam Ali Zwiad

    2013-01-01

    Full Text Available Immediate partial denture is a choice of treatment due to various cases of teeth extraction such as badly carious teeth, periodontal disease, eruption problems, trauma, and other reasons. Many choices are used to replace the lost teeth; one of these choices is a removable plastic denture in which hot cured acrylic resin should be used to fabricate such denture. Aim of Study: To provide an applicable technique to fabricate an immediate partial denture by reducing and declining the prosthetic steps and some materials in proportional to the conventional method. Clinical Procedures: Maxillary and mandibular stone casts are mounted to a simple articulator and the procedures are explained as step by step to fabricate an immediate partial denture without using the conventional methods and material, just using a small quantity of white cold cure acrylic resin to fabricate the artificial teeth, hot cure acrylic resin for the denture base and mold made of a silicon impression material are used to fabricate an immediate partial denture. Conclusion: The finished immediate partial denture showed a good retention and produced the exact shapes and sizes of the extracted teeth with low cost and less time for a dentist and patient.

  20. Music-dependent memory in immediate and delayed word recall.

    Science.gov (United States)

    Balch, W R; Bowman, K; Mohler, L

    1992-01-01

    Undergraduate volunteers rated a series of words for pleasantness while hearing a particular background music. The subjects in Experiment 1 received, immediately or after a 48-h delay, an unexpected word-recall test in one of the following musical cue contexts: same cue (S), different cue (D), or no cue (N). For immediate recall, context dependency (S-D) was significant but same-cue facilitation (S-N) was not. No cue effects at all were found for delayed recall, and there was a significant interaction between cue and retention interval. A similar interaction was also found in Experiment 3, which was designed to rule out an alternative explanation with respect to distraction. When the different musical selection was changed specifically in either tempo or form (genre), only pieces having an altered tempo produced significantly lower immediate recall compared with the same pieces (Experiment 2). The results support a stimulus generalization view of music-dependent memory.

  1. Immediate use steam sterilization: it's all about the process.

    Science.gov (United States)

    Nania, Paula

    2013-07-01

    Proper reprocessing of surgical instrumentation assists in infection prevention efforts. Immediate use steam sterilization, previously known as flash sterilization, is an effective method of sterilization if it is performed according to manufacturers' validated instructions. Items that undergo immediate use steam sterilization are subject to the same cleaning and decontamination requirements that apply to preparing items for terminal sterilization, and manufacturers' instructions for use must be strictly followed. In 2009, The Joint Commission revised its position statement on flash sterilization and emphasized that three critical steps of reprocessing must be followed to ensure sterility (ie, cleaning and decontamination, sterilization, aseptic transfer) and that complete documentation must be available for each immediate use steam sterilization cycle so that the device is traceable to the patient if problems arise. Copyright © 2013 AORN, Inc. Published by Elsevier Inc. All rights reserved.

  2. Prosthetic abutment influences bone biomechanical behavior of immediately loaded implants.

    Science.gov (United States)

    Camargos, Germana de Villa; Sotto-Maior, Bruno Salles; Silva, Wander José da; Lazari, Priscilla Cardoso; Del Bel Cury, Altair Antoninha

    2016-05-31

    This study aimed to evaluate the influence of the type of prosthetic abutment associated to different implant connection on bone biomechanical behavior of immediately and delayed loaded implants. Computed tomography-based finite element models comprising a mandible with a single molar implant were created with different types of prosthetic abutment (UCLA or conical), implant connection (external hexagon, EH or internal hexagon, IH), and occlusal loading (axial or oblique), for both immediately and delayed loaded implants. Analysis of variance at 95%CI was used to evaluate the peak maximum principal stress and strain in bone after applying a 100 N occlusal load. The results showed that the type of prosthetic abutment influences bone stress/strain in only immediately loaded implants. Attachment of conical abutments to IH implants exhibited the best biomechanical behavior, with optimal distribution and dissipation of the load in peri-implant bone.

  3. Prosthetic abutment influences bone biomechanical behavior of immediately loaded implants

    Directory of Open Access Journals (Sweden)

    Germana de Villa CAMARGOS

    2016-01-01

    Full Text Available Abstract This study aimed to evaluate the influence of the type of prosthetic abutment associated to different implant connection on bone biomechanical behavior of immediately and delayed loaded implants. Computed tomography-based finite element models comprising a mandible with a single molar implant were created with different types of prosthetic abutment (UCLA or conical, implant connection (external hexagon, EH or internal hexagon, IH, and occlusal loading (axial or oblique, for both immediately and delayed loaded implants. Analysis of variance at 95%CI was used to evaluate the peak maximum principal stress and strain in bone after applying a 100 N occlusal load. The results showed that the type of prosthetic abutment influences bone stress/strain in only immediately loaded implants. Attachment of conical abutments to IH implants exhibited the best biomechanical behavior, with optimal distribution and dissipation of the load in peri-implant bone.

  4. Evaluation of stability of immediately placed implants in infected sockets

    Directory of Open Access Journals (Sweden)

    Uma Shankar Pal

    2013-01-01

    Full Text Available Purpose: To describe a protocol for the immediate placement of implant into the infected alveolar socket. Materials and Methods: In this study, a total number of 40 implants were placed immediately into the extraction sockets. Each case had a different periapical condition (acute, endodontic and periodontal infection. Great care had been taken in debridement of the socket, extraction of tooth/teeth and guided bone regeneration along with the use of pre-operative and post-operative anti-microbial agent. Results: All except three implants were osseo-integrated within 6 months to 1 year. The complications were due to the extraction procedure and bone regeneration process. Conclusion: Predisposing factors for failures are incomplete debridement of the socket, poor oral hygiene, incomplete closure of the wound, and systemic factors like hormones. From this study, we may conclude that immediate implants are a viable treatment option for patients with periapical infections.

  5. Immediate Versus Early Loading and Conventional Loading in Implant Dentistry

    Directory of Open Access Journals (Sweden)

    Hassan Maghaireh

    2013-12-01

    Full Text Available To minimize the risk of implant failures after their placement, dental implants are traditionally kept load-free for 3 to 8 months to establish osseointegration before connecting the prosthetic super-structure (conventional loading. However, implant dentists are under continuous pressure from the media and patients to speed up the treatment and reduce number of visits during the implant therapy. Immediate implant loading can also reduce the cost and might also improve aesthetics as claimed by some surgeons. This pressure from the media, patients and dentists was behind introducing changes into the loading protocols and nowadays implants are loaded early and even immediately and it would be useful to know whether there is a difference in success rates between immediately and early loaded implants compared with conventionally loaded implants. It is well known that whenever a clinician is faced with a clinical question, the answer(s should be evidence based to avoid the risk of bias as opinion based answers can be misleading and can cause more failures in the dental practice. This mini-review aims to evaluate the effects of (1 immediate (within 1 week, (2 early (between 1 week and 2 months, and (3 conventional (after 2 months loading of osseointegrated dental implants. The review found no evidence that attaching artificial teeth either immediately, after 6 weeks (early or after at least 3 months (conventional led to any important differences in the failure of the implant or the artificial tooth, or to the amount of bone which surrounded the implant (any bone loss would be an undesirable consequence. However, we found a trend of more failures and complications with early loading when compared to immediate or conventional loading. More research is needed in this area. - See more at: http://smiledentaljournal.com/article.php?id=59#sthash.mniQLIcf.dpuf

  6. Immediate Desensitization in Teeth Affected by Amelogenesis Imperfecta.

    Science.gov (United States)

    Moreira, Rudá França; Figueiredo, Rossana Gomes; Oliveira, Henrique Eduardo; Fonseca, Ana Christina Lamosa da; Miranda, Mauro Sayão de

    2016-01-01

    The aim of this paper was to describe a clinical case of immediate dental desensitization using a self-etch adhesive system in an adolescent patient diagnosed with amelogenesis imperfecta (AI). AI was associated with severe tooth sensitivity, treated by the application of a universal adhesive system for desensitization of the teeth affected by AI. Reduction of tooth sensitivity was assessed using a visual analog scale during all reevaluations. The technique was effective for reducing tooth sensitivity. It was concluded that the adhesive system for tooth desensitization had an immediate effect and maintained its effectiveness during a 12-month follow-up period.

  7. Transmyometrial embryo transfer after difficult immediate mock transcervical transfer.

    Science.gov (United States)

    Sharif, K; Afnan, M; Lenton, W; Bilalis, D; Hunjan, M; Khalaf, Y

    1996-05-01

    To evaluate the place of ultrasound-directed transvaginal transmyometrial ET in a protocol using both the transcervical and transmyometrial routes in a step-wise fashion. A prospective descriptive clinical study. A university-based assisted conception unit. Thirteen patients who had difficult or impossible mock transcervical ET immediately before the real transfer. Ultrasound-directed transvaginal transmyometrial ET. Pregnancy and clinical pregnancy. Four patients became pregnant, including three with clinical pregnancies. In cases in which transcervical ET isd difficult or impossible, transvaginal transmyometrial ET is a viable option. The use of mock transcervical ET immediately before the real transfer would identify patients needing transmyometrial ET.

  8. Limiting the immediate and subsequent hazards associated with wildfires

    Science.gov (United States)

    DeGraff, Jerome V.; Cannon, Susan H.; Parise, Mario

    2013-01-01

    Wildfire is a unique natural hazard because it poses immediate threats to life and property as well as creating conditions that can lead to subsequent debris flows. In recent years, the immediate destructive force of wildfires has been decreased through better understanding of fire behavior. Lightning detection networks now identify the number and locations of this common ignition source. Measurements of wind speed, temperature, slope, fuel types and fire boundaries are routinely incorporated into models for fire spread, permitting real-time adjustments to fire-fighting strategies, thus increasing fire-fighting effectiveness.

  9. [Immediate complications of feeding percutaneous gastrostomy: a 10-year experience].

    Science.gov (United States)

    Chicharro, L; Puiggrós, C; Cots, I; Pérez-Portabella, C; Planas, M

    2009-01-01

    Percutaneous gastrostomy feeding tube (PG) may be beneficial in some patients, in others such as advanced dementia or rapidly progressive diseases its value is being questioned. Patient selection is important to identify those who will benefit from PG. This study aims to identify patients factors that may help in patient selection for PG. To analyse the characteristics of this patient's cohort and to describe the immediate complications of the procedure that we have defined as the ones happened in the first 30 days. To compare the two patient's group -with and without- immediate complications, non-parametric tests were used.

  10. Current status of frameless anchored IUD for immediate intracesarean insertion.

    Science.gov (United States)

    Wildemeersch, Dirk; Goldstuck, Norman D; Hasskamp, Thomas

    2016-01-01

    Immediate postpartum intrauterine device (IUD) insertion deserves great attention as it can provide immediate, timely and convenient contraception plus the added benefit of preventing repeat unintended pregnancies. Although women post vaginal delivery can benefit from immediate post-placenta contraception, women undergoing Cesarean section clearly need contraception, as an inter-delivery interval shorter than 18 months places them at a high risk for uterine rupture. The main drawback of currently available framed IUD devices for immediate postpartum insertion of an IUD is their high expulsion and displacement rates when inserted immediately postpartum after both vaginal and Cesarean delivery. Current research suggests that a brief window of opportunity exists of 10 minutes for insertion of conventional IUDs after which time expulsion rates both immediately and over time are greatly enhanced. This paper summarizes the current research conducted to overcome the expulsion problems associated with conventional T-shaped devices as well as through the use of an anchored frameless device. In the 1970s and 1980s, attempts were made to solve the expulsion problem by modifying existing devices, such as adding absorbable sutures (Delta-T) or additional appendages. These attempts proved to be clinically unsuccessful as the catgut suture added to the transverse arms did not provide sufficient resistance to prevent downward displacement and expulsion. An anchoring technique to suspend a copper IUD to the fundus of the uterus was developed in Belgium in the 1980s and has been the subject of extensive ongoing clinical research since 1985. Recently the frameless copper releasing anchor IUD, GyneFix, has been tested for postplacental insertion. Initially, the anchor was modified by the inclusion of a biodegradable cone which was added below the anchoring knot. Clinical studies confirmed the adequacy of this approach suggesting that it was technically possible to anchor an IUD

  11. Adherence with Universal Precautions after Immediate, Personalized Performance Feedback

    Science.gov (United States)

    Luke, Molli M.; Alavosius, Mark

    2011-01-01

    We evaluated the effects of immediate, personalized performance feedback on adherence with hand hygiene by health-care staff in the context of a multiple baseline design across participants. Target behaviors reached mastery levels and were maintained near 100% throughout 2 months of maintenance probes. (Contains 1 table and 1 figure.)

  12. Biowaiver monographs for immediate release solid oral dosage forms: prednisolone.

    NARCIS (Netherlands)

    Vogt, M; Derendorf, H; Krämer, J; Junginger, H E; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2007-01-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing prednisolone are reviewed. Data on its solubility, oral absorption, and permeability are not totally conclusive, but strongl

  13. Biowaiver monographs for immediate release solid oral dosage forms: cimetidine.

    NARCIS (Netherlands)

    Jantratid, E; Prakongpan, S; Dressman, J B; Amidon, G L; Junginger, H E; Midha, K K; Barends, D M

    2006-01-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing cimetidine are reviewed. According to the current Biopharmaceutics Classification System (BCS), cimetidine would be assigned

  14. Immediate psycho-social support for disaster survivors

    DEFF Research Database (Denmark)

    Berliner, Peter; Navarro Gongóra, José; Espaillat, Vanessa

    2011-01-01

    The article describes how psychosocial support in the immediate and mid-term disaster response for Haitian earthquake survivors in hospitals in the Dominican Republic could ameliorate some of the suffering and prevent the crisis from becoming crystallized into symptoms and complex grief...

  15. The feasibility of immediately loading dental implants in edentulous jaws.

    Science.gov (United States)

    Henningsen, Anders; Smeets, Ralf; Wahidi, Aria; Kluwe, Lan; Kornmann, Frank; Heiland, Max; Gerlach, Till

    2016-08-01

    Immediate loading of dental implants has been proved to be feasible in partially edentulous jaws. The purpose of this retrospective investigation was to assess the feasibility of immediately loading dental implants in fully edentulous jaws. A total of 24 patients aged between 53 and 89 years received a total of 154 implants in their edentulous maxillae or mandibles. Among the implants, 45 were set in fresh extracted sockets and 109 in consolidated alveolar bones. The implants were provisionally managed with chair-side made provisional resin bridges and exposed to immediate loading. Implants were followed up for 1-8 years, including radiographic imaging. Marginal bone levels were evaluated based on radiographic imaging. A total of 148 out of the 154 implants survived over the follow-up period of 1 to 8 years, giving a survival rate of 96%. The time or region of the implantation, the pre-implant augmentation, and the length and diameter of the implants had no statistically significant influence on the survival or the success rate. The marginal bone level remained stable with only minimal loss of 0.3 mm after 60 months of loading. Within the limitations of this study, immediate loading is feasible for dental implants in edentulous jaws.

  16. Cerebral Tissue Oxygenation during Immediate Neonatal Transition and Resuscitation

    Science.gov (United States)

    Pichler, Gerhard; Schmölzer, Georg M.; Urlesberger, Berndt

    2017-01-01

    This article provides a review of cerebral tissue oxygenation during immediate transition after birth in human neonates. Recommended routine monitoring, especially if resuscitation is needed, during this period includes arterial oxygen saturation and heart rate measured by pulse oximetry and electrocardiogram. However, there is increasing interest to monitor in addition with near-infrared spectroscopy (NIRS) the oxygenation of the brain. There is a different pattern of increase between cerebral tissue oxygenation and arterial oxygen saturation during the immediate transition, with cerebral tissue oxygenation reaching a plateau faster than arterial oxygen saturation. Differences can be explained, since cerebral tissue oxygenation is not only affected by arterial oxygen saturation but also by cerebral blood flow, hemoglobin content, and cerebral oxygen consumption. Normal values have already been established for different devices, gestational ages, and modes of delivery in neonates without any medical support. Cerebral hypoxia during immediate transition might cause brain damage. In preterm neonates with cerebral hemorrhage evolving in the first week after birth, the cerebral tissue oxygenation is already lower in the first minutes after birth compared to preterm neonates without cerebral hemorrhage. Using cerebral NIRS in combination with intervention guidelines has been shown to reduce the burden of cerebral hypoxia in preterm neonates. Cerebral tissue oxygenation during immediate transition seems to have an impact on outcome, whereby NIRS monitoring is feasible and has the advantage of continuous, non-invasive recording. The impact of NIRS monitoring and interventions on short- and long-term outcomes still need to be evaluated. PMID:28280719

  17. Effects of smoking cues in movies on immediate smoking behavior

    NARCIS (Netherlands)

    Lochbuehler, K.; Peters, M.; Scholte, R.H.J.; Engels, R.C.M.E.

    2010-01-01

    Introduction: The objective of this study was to investigate the effect of smoking cues in movies on immediate smoking behavior. We tested whether smokers who are confronted with smoking characters in a movie smoke more cigarettes while watching than those confronted with non-smoking characters and

  18. Immediate dental implant placement in the aesthetic zone

    NARCIS (Netherlands)

    Slagter, Kirsten Willemijn

    2016-01-01

    After pulling a tooth when aesthetics play a role, there is a tendency to place a dental implant immediately after pulling the tooth, preferably in combination with a temporary crown. This tendency is probably related to evolving society factors, with more demanding patients and a wish for an aesthe

  19. IMMEDIATE VERSUS DELAYED LOADING IMPLANTS: RATIONALE AND CONTROVERSIES.

    Science.gov (United States)

    Corradini, G; Delle Donne, U; Boni, W; Tettamanti, L; Tagliabue, A

    2015-01-01

    Loading implants immediately after their position in alveolar bone crest is a procedure that has become popular in the last decade. The aim of this study is to evaluate the survival rate of 811 immediate loaded implants (ILIs). In the period between January 2008 and December 2013, 877 patients (498 females and 379 males) were operated at the BDD private Practice Clinic (Milan, Italy). The mean post-surgical follow-up was 30±17 months (max – min, 84 – 1). One thousasnd three hundred and eighty-six fixtures (EDIERRE Implant System SpA, Genoa, Italy) were evaluated in the present study, 811 immediately loaded and 575 loaded after 3 months. All patients underwent the same surgical protocol and agreed to participate in a post-operative check-up program. SPSS program was used for statistical analysis. Survival rate (SVR) was 97.3% since only 38 fixtures were lost from a total of 1,348 implants. Cross-tabulation between failures demonstrated slight but significant worse results for ILIs (p= 0.037). There were 28 failures out of 811 ILIs whereas only 10 fixtures were lost out of 565 implants loaded after 3 months. Immediate loading performed in selected cases is a reliable tool for oral rehabilitation.

  20. The Aesthetic As Immediately Sensuous: An Historical Perspective

    Science.gov (United States)

    Madenfort, Duke

    1974-01-01

    The views of Immanuel Kant, Soren Kierkegaard, Henri Bergson, John Dewey, and Susanne Langer were discussed. In this article they served as five important figures in a historical account of the concept of the aesthetic as the immediately sensuous. (Author/RK)

  1. Futur "simple" et futur "proche" ("Simple" Future and "Immediate" Future).

    Science.gov (United States)

    Franckel, Jean-Jacques

    1984-01-01

    An analysis of the use of simple and immediate future tenses in French shows that the expression of time is controlled more by context and modals than by specifically temporal cues. The role of negation in this situation is discussed. (MSE)

  2. The Functions of Immediate Echolalia in Autistic Children.

    Science.gov (United States)

    Prizant, Barry M.; Duchan, Judith F.

    1981-01-01

    A multilevel analysis of verbal and nonverbal factors, response latency, and intonation, in four autistic boys (4 to 9 years old) revealed that immediate echolalia is far more than a meaningless behavior. Seven functional categories of echolalia were discovered and are discussed in reference to behavioral and linguistic features of each category.…

  3. Immediate implant placement and provisionalisation in the aesthetic zone

    NARCIS (Netherlands)

    Van Nimwegen, W G; Goené, R J; Van Daelen, A C L; Stellingsma, K; Raghoebar, G M; Meijer, H J A

    2016-01-01

    The aim of this retrospective study was to assess the outcome of immediate single-tooth implant placement and provisionalisation in the aesthetic zone regarding hard and soft peri-implant tissue parameters and patient-related outcome measures in a private practice. All consecutively treated patients

  4. Necessity of immediate cardiopulmonary resuscitation in trauma emergency

    Directory of Open Access Journals (Sweden)

    Luciano Baitello

    2010-08-01

    Full Text Available Abstract The ability to respond quickly and effectively to a cardiac arrest situation rests on nurses being competent in the emergency life-saving procedure of cardiopulmonary resuscitation. The objective of the current study was to evaluate the types of trauma and survival of patients that require immediate cardiopulmonary resuscitation in trauma emergencies. A total of 13301 patients treated as accident victims between July 2004 and December 2006 were evaluated in a prospective study. Patients requiring immediate cardiopulmonary resuscitation at admission were identified. The type of injury and the survival of these patients were evaluated. Of the 65 patients included in the study, 30% had suffered from gunshot wounds, 19% had been run over, 18% had been involved in car crashes, 13% in motor cycle accidents, 9% stabbings, 1% by cycle accidents and 10% other types of accidents including burns, hangings and falls. In only 12 of these patients, immediate resuscitation was successful and procedure such as chest drainage, exploratory laparotomy and interventions in the surgical center were performed. However all patients evolved to death; eight within 24 hours, two between 24 and 48 hours and the other 2 after 48 hours. Immediate cardiopulmonary resuscitation after accidents is a sign of high mortality requiring further studies to review indication and the ethical aspects involved.

  5. Placenta previa and immediate outcome of the term offspring.

    Science.gov (United States)

    Walfisch, Asnat; Sheiner, Eyal

    2016-10-01

    Immediate neonatal outcome in pregnancies complicated by placenta previa is largely dependent on gestational age. We aimed to investigate whether placenta previa increases the risk for perinatal mortality and immediate morbidity of the offspring born at term. A population-based cohort study included all singleton pregnancies, with and without placenta previa, delivered at term. Maternal and pregnancy characteristics as well as immediate neonatal morbidity and mortality were compared. Deliveries occurred between the years 1991-2013 in a tertiary medical center. Multiple pregnancies, and fetal congenital malformations were excluded. During the study period 233,123 consecutive term deliveries met the inclusion criteria; 0.2 % of the babies were born to mothers diagnosed with placenta previa. Women with placenta previa were significantly older and more likely to have had a previous cesarean section. Pregnancies were more likely to be complicated with pathological presentations and cesarean hysterectomies. Babies born at term following pregnancies with placenta previa were more likely to weigh less than 2500 g (OR 2.78 CI 1.9-3.9, p placenta previa pregnancies involve higher maternal morbidity rates, term offsprings are not at an increased risk for immediate adverse outcome.

  6. Effects of smoking cues in movies on immediate smoking behavior

    NARCIS (Netherlands)

    Lochbuehler, K.; Peters, M.; Scholte, R.H.J.; Engels, R.C.M.E.

    2010-01-01

    Introduction: The objective of this study was to investigate the effect of smoking cues in movies on immediate smoking behavior. We tested whether smokers who are confronted with smoking characters in a movie smoke more cigarettes while watching than those confronted with non-smoking characters and

  7. Effects of smoking cues in movies on immediate smoking behavior

    NARCIS (Netherlands)

    Lochbühler, K.C.; Peters, P.M.; Scholte, R.H.J.; Engels, R.C.M.E.

    2010-01-01

    The objective of this study was to investigate the effect of smoking cues in movies on immediate smoking behavior. We tested whether smokers who are confronted with smoking characters in a movie smoke more cigarettes while watching than those confronted with non-smoking characters and whether this e

  8. 16 CFR 315.4 - Limits on requiring immediate payment.

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Limits on requiring immediate payment. 315.4 Section 315.4 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS... for an eye examination, fitting, and evaluation before the release of a contact lens prescription,...

  9. Exploring the Effect of Immediate Video Feedback on Coaching

    Science.gov (United States)

    Suhrheinrich, Jessica; Chan, Janice

    2017-01-01

    Although evidence-based practices for autism spectrum disorders exist, they are often not effectively incorporated into school-based programs, indicating a need for enhanced training strategies for educators. This study examined the effects of immediate video feedback during coaching for teachers and paraprofessionals learning Classroom Pivotal…

  10. Immediate and delayed contact hypersensitivity to verbena plants

    DEFF Research Database (Denmark)

    Potter, P C; Mather, S; Lockey, P

    1995-01-01

    , a common perennial in South African gardens. The other case was a 23-year-old female gardener who developed immediate and delayed-type contact dermatitis from Verbena elegans 'Cleopatra' produced in a Danish nursery. Prick tests to plant material were considered positive and of an allergic nature....

  11. The Aesthetic As Immediately Sensuous: An Historical Perspective

    Science.gov (United States)

    Madenfort, Duke

    1974-01-01

    The views of Immanuel Kant, Soren Kierkegaard, Henri Bergson, John Dewey, and Susanne Langer were discussed. In this article they served as five important figures in a historical account of the concept of the aesthetic as the immediately sensuous. (Author/RK)

  12. 9 CFR 93.326 - Horses for immediate slaughter.

    Science.gov (United States)

    2010-01-01

    ..., and 93.323 for immediate slaughter if accompanied by a certificate of a salaried veterinarian of the Mexican Government, or by a certificate issued by a veterinarian accredited by the Mexican Goverment and endorsed by a salaried veterinarian of the Mexican Government, thereby representing that the veterinarian...

  13. Prediction of immediately occurring microsleep events from brain electric signals

    Directory of Open Access Journals (Sweden)

    Golz Martin

    2016-09-01

    Full Text Available This contribution addresses the question if imminent changes of the cortical state are predictable. The analysis is based on 1484 examples of microsleep (MS and 1940 counterexamples of sustained attention (SA, both observed during overnight driving in the simulator. EEG segments (8 s in length immediately before each respective event were included. Features were extracted by (i modified periodogram and (ii Choi-Williams distribution. Machine learning algorithms, namely the optimized learning vector quantization (OLVQ and the support-vector machine with Gaussian kernel function (SVM, were trained in order to map signal features to the event type (MS or SA. Cross validation analysis yielded test set classification accuracies of 87.5 ± 0.1 % and 82.7 ± 0.1 % for feature set (i and (ii, respectively. In general, SVM outperformed OLVQ. In conclusion, EEG contains enough information to predict immediately upcoming microsleep events.

  14. Formulation and Dissolution Study of Valsartan Immediate Release Tablets

    Directory of Open Access Journals (Sweden)

    B. Brahmaiah*, K. Sasikanth, Sreekanth Nama , P.Suresh, Patan Adam Khan

    2013-06-01

    Full Text Available In the present study, design of oral immediate release tablets of Valsartan by direct compression techniquewas carried out. The main aim and objective of the work is to formulate immediate release tablets usingdifferent direct compression vehicles (DCV’S in different ratios. The main motive is to compare thedissolution profile of these formulations and conclude the best formulation which release drug at a fasterrate. To determine the best fit dissolution profile for the dosage forms. Valsartan tablets were formulated byusing microcrystalline cellulose (diluents, potato starch, acacia (binder and magnesium stearate(lubricant. The granules were compressed into tablets and were subjected to dissolution studies. Thedissolution profile of the formulation F2 was found to have better dissolution rate compared to others. TheIn-vitro dissolution studies of all the formulations were conducted and the results were obtained, it wasconcluded that formulation F2 was the best with fast release of drug compared to others.

  15. Immediate postoperative complications in transsphenoidal pituitary surgery: A prospective study

    Directory of Open Access Journals (Sweden)

    Tumul Chowdhury

    2014-01-01

    Full Text Available Background: Considering the important role of pituitary gland in regulating various endocrine axes and its unique anatomical location, various postoperative complications can be anticipated resulting from surgery on pituitary tumors. We examined and categorized the immediate postoperative complications according to various tumor pathologies. Materials and Methods: We carried out a prospective study in 152 consecutive patients and noted various postoperative complications during neurosurgical intensive care unit stay (within 48 hrs of hospital stay in patients undergoing transsphenoidal removal of pituitary tumors. Results: In our series, various groups showed different postoperative complications out of which, cerebrospinal fluid leak was the commonest followed by diabetes insipidus, postoperative nausea and vomiting, and hematoma at operation site. Conclusion: Various immediate postoperative complications can be anticipated in transsphenoidal pituitary surgery even though, it is considered to be relatively safe.

  16. Age differences in learning, immediate and one week delayed recall.

    Science.gov (United States)

    Schneider, N G; Gritz, E R; Jarvik, M E

    1975-01-01

    In an initial study, differences in learning and immediate recall were observed for groups of young and aged subjects on several measures. Retest date showed some differential loss for aged subjects after 1 week. Conclusions regarding long-term retention per se were not possible due to the nature of the design. In a second study, additional aged and young groups of subjects were run under delayed recall conditions. The data from these two groups were combined with data from the first study, with care taken to match subjects on a number of variables (health, education, intelligence). The results showed age-related differences for measures of learning and immediate recall but not for delayed 1 week retention.

  17. Immediate complications of percutaneous central venous cannulation in children

    Science.gov (United States)

    Dheer, Geetika; Chaudhry, Gurmeet Kaur; Singh, Tejinder

    2011-01-01

    Objective: To study the incidence of immediate complications associated with percutaneous central venous catheterization. Materials and Methods: A total of 103 central venous catheters were inserted in 70 children over a period of 18 months, governed by a uniform protocol. Sixty-three percent of the catheters were inserted in neonates, 23.3% in infants and 13.6% in children between 1 and 12 years of age. Statistical Analysis Used: Software SPSS version 15. Results: There were a total of 41 insertion-related immediate complications, of which 75.6% were in neonates. Neonatal age, hemodynamic instability and more number of attempts to catheterize the vein had a higher risk of insertion-related problems. There was no mortality directly as a result of the procedure. Conclusion: In our practice, it was observed that complications were fewer with increasing familiarity with the procedure. Hence, percutaneous central venous catheterization is a safe procedure when performed in experienced hands. PMID:22121313

  18. Immediate complications of percutaneous central venous cannulation in children

    Directory of Open Access Journals (Sweden)

    Geetika Dheer

    2011-01-01

    Full Text Available Objective: To study the incidence of immediate complications associated with percutaneous central venous catheterization. Materials and Methods: A total of 103 central venous catheters were inserted in 70 children over a period of 18 months, governed by a uniform protocol. Sixty-three percent of the catheters were inserted in neonates, 23.3% in infants and 13.6% in children between 1 and 12 years of age. Statistical Analysis Used: Software SPSS version 15. Results: There were a total of 41 insertion-related immediate complications, of which 75.6% were in neonates. Neonatal age, hemodynamic instability and more number of attempts to catheterize the vein had a higher risk of insertion-related problems. There was no mortality directly as a result of the procedure. Conclusion: In our practice, it was observed that complications were fewer with increasing familiarity with the procedure. Hence, percutaneous central venous catheterization is a safe procedure when performed in experienced hands.

  19. Influences of speech familiarity on immediate perception and final comprehension.

    Science.gov (United States)

    Perry, Lynn K; Mech, Emily N; MacDonald, Maryellen C; Seidenberg, Mark S

    2017-05-01

    Unfamiliar speech-spoken in a familiar language but with an accent different from the listener's-is known to increase comprehension difficulty. However, there is evidence of listeners' rapid adaptation to unfamiliar accents (although perhaps not to the level of familiar accents). This paradox might emerge from prior focus on isolated word perception and/or use of single comprehension measures. We investigated processing of fluent connected speech spoken either in a familiar or unfamiliar accent, using participants' ability to "shadow" the speech as an immediate measure as well as a comprehension test at passage end. Shadowing latencies and errors and comprehension errors increased for Unfamiliar relative to Familiar Speech conditions, especially for relatively informal rather than more academic content. Additionally, there was evidence of less adaptation to Unfamiliar than Familiar Speech. These results suggest that unfamiliar speech imposes costs, especially in the immediate timescale of perceiving speech.

  20. Immediate sensitivity to structural constraints in pronoun resolution

    Directory of Open Access Journals (Sweden)

    Wing Yee eChow

    2014-06-01

    Full Text Available Real-time interpretation of pronouns is sometimes sensitive to the presence of grammatically-illicit antecedents, and sometimes not. This occasional sensitivity has been taken as evidence that structural constraints do not immediately impact the initial antecedent retrieval for pronoun interpretation. We argue that it is important to separate effects that reflect the initial antecedent retrieval process from those that reflect later processes. We present results from five reading comprehension experiments. Both the current results and previous evidence support the hypothesis that agreement features and structural constraints immediately constrain the antecedent retrieval process for pronoun interpretation. Occasional sensitivity to grammatically-illicit antecedents may be due to repair processes triggered when the initial retrieval fails to return a grammatical antecedent.

  1. Chunk Limits and Length Limits in Immediate Recall: A Reconciliation

    Science.gov (United States)

    Chen, Zhijian; Cowan, Nelson

    2005-01-01

    Whereas some research on immediate recall of verbal lists has suggested that it is limited by the number of chunks that can be recalled (e.g., N. Cowan, Z. Chen, & J. N. Rouder, 2004; E. Tulving & J. E. Patkau, 1962), other research has suggested that it is limited by the length of the material to be recalled (e.g., A. D. Baddeley, N. Thomson, &…

  2. Biowaiver monographs for immediate release solid oral dosage forms: prednisolone.

    OpenAIRE

    Vogt, M.; Derendorf, H; Krämer, J.; Junginger, H E; Midha, K.K.; Shah, V. P.; Stavchansky, S; Dressman, J B; Barends, D M

    2007-01-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing prednisolone are reviewed. Data on its solubility, oral absorption, and permeability are not totally conclusive, but strongly suggest a BCS Class 1 classification. Prednisolone's therapeutic indications and therapeutic index, pharmacokinetics, and the possibility of excipient interactions were also taken into considerat...

  3. Biowaiver monographs for immediate release solid oral dosage forms: cimetidine.

    OpenAIRE

    Jantratid, E; Prakongpan, S.; Dressman, J B; Amidon, G L; Junginger, H E; Midha, K.K.; Barends, D M

    2006-01-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing cimetidine are reviewed. According to the current Biopharmaceutics Classification System (BCS), cimetidine would be assigned to Class III. Cimetidine's therapeutic use and therapeutic index, its pharmacokinetic properties, data related to the possibility of excipient interactions, and reported BE/bioavailability (BA) pr...

  4. Effects of immediate modified feeding on infantile gastroenteritis.

    OpenAIRE

    Hoghton, M A; Mittal, N K; Sandhu, B K; Mahdi, G

    1996-01-01

    BACKGROUND: Standard treatment of infants who are dehydrated as a result of acute gastroenteritis is to administer oral rehydration therapy (ORT). Traditionally, food has been withdrawn for 24-48 h, but there is no conclusive evidence that this is of any real benefit to the patient. Immediate modified feeding, in which an infant on ORT is not starved but administered a limited diet, may have benefits in the treatment of gastroenteritis, especially in children who are nutritionally compromised...

  5. Type I immediate hypersensitivity reaction to cyanocobalamin but not hydroxycobalamin.

    Science.gov (United States)

    Moloney, F J; Hughes, R; O'Shea, D; Kirby, B

    2008-07-01

    We report a case of a 42-year-old woman with a background of autoimmune polyglandular syndrome, who developed a type I immediate hypersensitivity reaction to intramuscular cyanocobalamin. Intradermal testing showed a positive reaction to cyanocobalamin. The patient was subsequently treated with intramuscular hydroxycobalamin after negative intradermal testing to this alternative B(12) compound. A review of previously described cases of hypersensitivity to either compound provides a rationale for the management of this rare but serious side-effect.

  6. Prosthetic abutment influences bone biomechanical behavior of immediately loaded implants

    OpenAIRE

    Camargos, Germana de Villa; SOTTO-MAIOR,Bruno Salles; Silva,Wander José da; Priscilla Cardoso LAZARI; Del Bel Cury, Altair Antoninha

    2016-01-01

    Abstract This study aimed to evaluate the influence of the type of prosthetic abutment associated to different implant connection on bone biomechanical behavior of immediately and delayed loaded implants. Computed tomography-based finite element models comprising a mandible with a single molar implant were created with different types of prosthetic abutment (UCLA or conical), implant connection (external hexagon, EH or internal hexagon, IH), and occlusal loading (axial or oblique), for both i...

  7. Clinical Evidence for Regenerative Endodontic Procedures: Immediate versus Delayed Induction?

    Science.gov (United States)

    Botero, Tatiana M; Tang, Xianli; Gardner, Richard; Hu, Jan C C; Boynton, James R; Holland, G Rex

    2017-09-01

    Clinicians face many challenges when treating immature permanent teeth in young patients. Immediate blood clot induction can be a successful option as described by some case reports. No experimental studies or clinical trials have addressed this question. We have designed a clinical trial in which we hypothesized that there is no difference in success between immediate or delayed induction protocols. After confirmation of pulpal necrosis, patients were randomized. In the delayed group, 15 teeth were treated following the American Association of Endodontists guidelines, and calcium hydroxide was used as the intracanal medication. In the immediate group, 13 teeth had a blood clot inducted at the first appointment. The teeth were evaluated after 1, 3, and 12 months. Three independent evaluators assessed the periapical healing. The Pearson chi-square test or the Fisher exact test was used to compare the success rates between the 2 groups. Currently, of the 25 recruited patients (28 teeth), 19 have completed their 12-month follow-up. The group with delayed induction had a 71% success rate, and the group with immediate induction had a 33% success rate. In most cases (79%), trauma was the etiology. All successful cases started at stage 9 of root development (Nolla), and the majority showed healing type 2. Determination of the stage of root formation and etiology are possible critical factors for any therapeutic decision. In summary, it is early to conclude or suggest any of the protocols. Clearly, much more data are needed before sample size requirements can be met. Copyright © 2017 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  8. Effects of immediate modified feeding on infantile gastroenteritis.

    OpenAIRE

    Hoghton, M A; Mittal, N K; Sandhu, B. K.; Mahdi, G

    1996-01-01

    BACKGROUND: Standard treatment of infants who are dehydrated as a result of acute gastroenteritis is to administer oral rehydration therapy (ORT). Traditionally, food has been withdrawn for 24-48 h, but there is no conclusive evidence that this is of any real benefit to the patient. Immediate modified feeding, in which an infant on ORT is not starved but administered a limited diet, may have benefits in the treatment of gastroenteritis, especially in children who are nutritionally compromised...

  9. Low scale inflation and the immediate heavy curvaton decay

    CERN Document Server

    Rodríguez, Y

    2004-01-01

    The end of a thermal inflation era, driven by the rolling of a flaton field coupled to the curvaton, triggers a huge increment in the curvaton mass and decay rate. It is shown that, if this increment is enough for the curvaton to immediately decay, low scale inflation is achieved for more natural values of the flaton-curvaton coupling constant $\\lambda$ and the curvaton bare mass $m_\\sigma$.

  10. Immediate Desensitization in Teeth Affected by Amelogenesis Imperfecta

    OpenAIRE

    Moreira,Rudá França; Figueiredo,Rossana Gomes; Oliveira,Henrique Eduardo de; Fonseca,Ana Christina Lamosa da; Miranda,Mauro Sayão de

    2016-01-01

    Abstract The aim of this paper was to describe a clinical case of immediate dental desensitization using a self-etch adhesive system in an adolescent patient diagnosed with amelogenesis imperfecta (AI). AI was associated with severe tooth sensitivity, treated by the application of a universal adhesive system for desensitization of the teeth affected by AI. Reduction of tooth sensitivity was assessed using a visual analog scale during all reevaluations. The technique was effective for reducing...

  11. Assistance in immediate puerperium: the role of physiotherapy

    Directory of Open Access Journals (Sweden)

    Juliana Schulze Burti

    2017-01-01

    Full Text Available Objective: To assess the effects of physical therapy intervention for women in immediately postpartum attended in a public hospital in the city of Barueri, São Paulo, Brazil. Methods: Women in the immediate postpartum period after vaginal delivery or cesarean section were included. They underwent a physical therapy evaluation, followed by a single intervention (45 minutes, including diaphragm and abdominal re-education exercises, pelvic floor muscle training, metabolic exercises, elimination of flatus maneuver and guidelines regarding posture, early walking and breastfeeding encouraging. Before and after intervention, the visual analogue scale (VAS of pain and the subjective scale for the general welfare were applied. For statistical analysis, the significance level used was 5%. Results: Fifty women, 25 vaginal deliveries and 25 caesarean sections were evaluated and treated. After intervention, which achieved 100% compliance, there was a significant improvement in pain in the cesarean group (3.99±2.11 to 2.85±2.63 and in the vaginal delivery group (2.00±1.52 to 1.34±0.92 (p<0.05. And 82% of the sample related improvement in general well-being, regardless of the type of delivery. Conclusion: The exercise protocol positively contributed to the improvement of pain and general well-being, diminishing discomforts of immediately postpartum.

  12. Economic model of observation versus immediate resection of hepatic adenomas.

    Science.gov (United States)

    Vanounou, Tsafrir; Groeschl, Ryan T; Geller, David A; Marsh, J Wallis; Gamblin, T Clark

    2012-09-15

    For small asymptomatic hepatic adenomas (HA), available data are insufficient to establish the superiority of either observation or surgery. We sought to investigate the cost-effectiveness of two initial management strategies. We performed a comparative analysis of two theoretical cohorts of 100 patients with small (cash flow (DCF) models compared the net present value (NPV) of both treatment options at year 10 under three distinct progression rate scenarios. A break-even (BE) analysis was used to determine the BE point at which the NPV for observation and immediate surgery intersect. The NPV for immediate surgery was $1,733,955. The NPV for observation varied between $2,065,315-$2,745,631 for computed tomography (CT), $2,264,575-$2,929,541 for magnetic resonance imaging (MRI), and $802,837-$1,580,413 for ultrasound (US). The BE point was between 6 and 8 years for CT and 5-7 years for MRI. The BE point for US was not reached except in the highest progression rate scenario (12 years). This study highlights the importance of the underlying progression rate and the cost of imaging when following patients with asymptomatic HA. Overall, US surveillance is the most cost-efficient approach to observing small asymptomatic HA. If cross-sectional imaging is utilized, then immediate surgery is the most cost-effective decision at 5-8 years. Copyright © 2012 Wiley Periodicals, Inc.

  13. Gene regulation in the immediate-early response process.

    Science.gov (United States)

    Bahrami, Shahram; Drabløs, Finn

    2016-09-01

    Immediate-early genes (IEGs) can be activated and transcribed within minutes after stimulation, without the need for de novo protein synthesis, and they are stimulated in response to both cell-extrinsic and cell-intrinsic signals. Extracellular signals are transduced from the cell surface, through receptors activating a chain of proteins in the cell, in particular extracellular-signal-regulated kinases (ERKs), mitogen-activated protein kinases (MAPKs) and members of the RhoA-actin pathway. These communicate through a signaling cascade by adding phosphate groups to neighboring proteins, and this will eventually activate and translocate TFs to the nucleus and thereby induce gene expression. The gene activation also involves proximal and distal enhancers that interact with promoters to simulate gene expression. The immediate-early genes have essential biological roles, in particular in stress response, like the immune system, and in differentiation. Therefore they also have important roles in various diseases, including cancer development. In this paper we summarize some recent advances on key aspects of the activation and regulation of immediate-early genes. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  14. Immediate effects of chocolate on experimentally induced mood states.

    Science.gov (United States)

    Macht, Michael; Mueller, Jochen

    2007-11-01

    In this work two hypotheses were tested: (1) that eating a piece of chocolate immediately affects negative, but not positive or neutral mood, and (2) that this effect is due to palatability. Experiment 1 (48 normal-weight and healthy women and men) examined the effects of eating a piece of chocolate and drinking water on negative, positive and neutral mood states induced by film clips. Eating chocolate reduced negative mood compared to drinking water, whereas no or only marginal effects were found on neutral and positive moods. Experiment 2 (113 normal-weight and healthy women and men) compared effects of eating palatable and unpalatable chocolate on negative mood, and examined the duration of chocolate-induced mood change. Negative mood was improved after eating palatable chocolate as compared to unpalatable chocolate or nothing. This effect was short lived, i.e., it disappeared after 3 min. In both experiments, chocolate-induced mood improvement was associated with emotional eating. The present studies demonstrate that eating a small amount of sweet food improves an experimentally induced negative mood state immediately and selectively and that this effect of chocolate is due to palatability. It is hypothesized that immediate mood effects of palatable food contribute to the habit of eating to cope with stress.

  15. Immediate-loading post extractive implants: indications, advantages and limits.

    Science.gov (United States)

    Mampieri, G; Ottria, L; Barlattani, A

    2008-07-01

    The possibility of rehabilitating immediately an edentulous patient offers today remarkable advantages because it satisfies the patient's demands for comfort, aesthetics, and functionality and reduces the surgical stages for the professional.In the last years clinicians and companies have been concentrating their efforts in the development of new surgical techniques and biomaterials in order to speed up the osteointegration process, which fosters the functionality, that is the immediate-loading.This clinical report, based on the analysis of the literature and on the presentation of a case report, shows how satisfying results in functionality and aesthetic can be obtained by a careful diagnosis and an accurate therapeutic planning, reducing at the same time the stress for the patient and the surgical stages for the professional.In any case, it is necessary to have the rehabilitations with immediate-loaded implants directed by workers with a good knowledge and experience in surgery, periodontology, and prosthesis or by a work team able to face all the complications such advanced rehabilitations may cause.

  16. Immediate re-transplantation following early kidney transplant thrombosis.

    LENUS (Irish Health Repository)

    Phelan, Paul J

    2012-02-01

    Allograft thrombosis is a devastating early complication of renal transplantation that ultimately leads to allograft loss. We report here on our experience of nine cases of immediate re-transplantation following early kidney transplant thrombosis at a single centre between January 1990 and June 2009. The mean age was 42.9 years at time of transplant. For seven patients, the allograft thrombosis was their first kidney transplant and seven of the nine cases had a deceased donor transplant. The initial transplants functioned for a mean of 1.67 days and the patients received a second allograft at a mean of 3.1 days after graft failure. All of the re-transplants worked immediately. Four allografts failed after a mean of 52.5 months (2-155 months). Two of these died with a functioning allograft, one failed owing to chronic allograft nephropathy and one owing to persistent acute cellular rejection. The remaining five patients still have a functioning allograft after a mean of 101.8 months (7-187 months). One year allograft and patient survival after re-transplantation were 87.5% and 100% respectively (after 5 years, both were 57%). Immediate re-transplantation following early kidney transplant thrombosis can be a success. It may be considered in selected cases after allograft thrombosis.

  17. Immediate versus Delayed Sarcoma Reconstruction: Impact on Outcomes

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    Kyle J. Sanniec

    2016-01-01

    Full Text Available Background. Sarcoma is a rare malignancy, and more recent management algorithms emphasize a multidisciplinary approach and limb salvage, which has resulted in an increase in overall survival and limb preservation. However, limb salvage has resulted in a higher rate of wound complications. Objective. To compare the complications between immediate and delayed (>three weeks reconstruction in the multidisciplinary limb salvage sarcoma patient population. Methods. A ten-year retrospective review of patients who underwent sarcoma resection was performed. The outcome of interest was wound complication in the postoperative period based on timing of reconstruction. We defined infection as any infection requiring intravenous antibiotics, partial flap failure as any flap requiring a debridement or revision, hematoma/seroma as any hematoma/seroma requiring drainage, and wound dehiscence as a wound that was not completely intact by three weeks postoperatively. Results. 70 (17 delayed, 53 immediate patients who underwent sarcoma resection and reconstruction met the inclusion criteria. Delayed reconstruction significantly increased the incidence of postoperative wound infection and wound dehiscence. There was no difference in partial or total flap loss, hematoma, or seroma between the two groups. Discussion and Conclusion. Immediate reconstruction results in decreased wound complications may reduce the morbidity associated with multidisciplinary treatment in the limb salvage sarcoma patient.

  18. FORMULATION AND EVALUATION OF CANDESARTAN CILEXETIL IMMEDIATE RELEASE TABLETS

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    Jampani Neeharika

    2012-07-01

    Full Text Available Candesartan Cilexetil is an esterified prodrug of Candesartan, a non-peptide angiotensin II type-1(AT1 receptor antagonist used in the treatment of hypertension and congestive heart failure. Candesartan meets the requirement of high potency but it is poorly absorbed when administered orally. Therefore, the prodrug Candesartan Cilexetil is developed. It is soluble in methylene chloride, half life is 5.1 to 10.5hrs and bioavailability is 15%. It is marketed as conventional tablets. In this work, it is formulated as immediate release tablets by changing the concentration of ingredients. For many drug substances, conventional immediate-release formulations provide clinically effective therapy while maintaining the required balance of pharmacokinetic and pharmacodynamic profiles with in acceptable level of safety to the patient. The immediate release formulation of Candesartan Cilexetil is prepared by wet granulation method to provide rapid onset of action. In order to optimize the best formulation, ten different trials are developed. The main ingredients used in the formulation are lactose monohydrate, PEG, calcium CMC and MCC. Weight variation, thickness, friability, disintegration time, in-vitro release, pharmaceutical assay are studied as response variables. The formulation containing 38% of MCC is selected as an optimized product in which the different physical properties and in-vitro release profile showed best comparable results with innovator product.

  19. Immediate hypersensitivity responses in the immunopathogenesis of human onchocerciasis.

    Science.gov (United States)

    Ottesen, E A

    1985-01-01

    It is not clear what role immediate hypersensitivity immune responses have in the pathogenesis of human onchocerciasis, but it is certain that these responses are prominent both in the course of natural infection and during the Mazzotti reactions that follow treatment with diethylcarbamazine. In humans, the levels of total serum IgE associated with onchocerciasis are as high or higher than those associated with almost any helminth infection, although specific IgE antibodies to Onchocerca volvulus appear to be a small and still poorly characterized fraction of the total serum IgE. Evidence about the relationship of these prominent IgE responses in patients with onchocerciasis to the onchocercal skin disease that manifests as pruritus and papular eruptions is conflicting, but in a guinea pig model of ocular pathology induced by onchocerca microfilariae evidence for the pathogenetic importance of IgE and immediate hypersensitivity is much less equivocal. The suggestive findings from this model make it imperative to carry out similar studies of Onchocerca-affected human eyes to determine whether immediate hypersensitivity responses play a similar critical role in the pathogenesis of the ocular lesions in humans.

  20. Immediate re-transplantation following early kidney transplant thrombosis.

    LENUS (Irish Health Repository)

    Phelan, Paul J

    2011-08-01

    Allograft thrombosis is a devastating early complication of renal transplantation that ultimately leads to allograft loss. We report here on our experience of nine cases of immediate re-transplantation following early kidney transplant thrombosis at a single centre between January 1990 and June 2009. The mean age was 42.9 years at time of transplant. For seven patients, the allograft thrombosis was their first kidney transplant and seven of the nine cases had a deceased donor transplant. The initial transplants functioned for a mean of 1.67 days and the patients received a second allograft at a mean of 3.1 days after graft failure. All of the re-transplants worked immediately. Four allografts failed after a mean of 52.5 months (2-155 months). Two of these died with a functioning allograft, one failed owing to chronic allograft nephropathy and one owing to persistent acute cellular rejection. The remaining five patients still have a functioning allograft after a mean of 101.8 months (7-187 months). One year allograft and patient survival after re-transplantation were 87.5% and 100% respectively (after 5 years, both were 57%). Immediate re-transplantation following early kidney transplant thrombosis can be a success. It may be considered in selected cases after allograft thrombosis.

  1. Immediate effects of two relaxation techniques on healthy volunteers.

    Science.gov (United States)

    Khemka, Sushilkumar S; Rao, Nagendra H Rama; Nagarathna, Raghuram

    2009-01-01

    This controlled study compared immediate effects of two relaxation techniques on state anxiety and sustained attention in healthy subjects. 86 volunteers (56 men and 30 women) were divided into two groups: the first 43 volunteers (age range 18 to 64) practiced 20 minutes of yoga-based Deep Relaxation Technique (DRT), while the second group of 43 volunteers (same age range), practiced 20 minutes Supine Rest (SR). State anxiety was assessed using the State Trait Anxiety Inventory (STAI A-State), and sustained attention was assessed using the Six Letter Cancellation (SLC) and Digit Letter Substitution (DLS) tests. All tests were administered immediately before, and immediately after, practice. A significant reduction in State Anxiety score (P < 0.001) was observed for the group practicing DRT, but not for the group practicing SR. For the sustained attention tests, however, there were significant increases in scores by both DRT and SR groups (P < 0.001). The results suggest that both interventions improve attention, but that only DRT reduces State Anxiety.

  2. Soft tissue conditioning by immediate restoration of immediately placed implants in full-arch rehabilitation: the double provisional technique.

    Science.gov (United States)

    Cordaro, Luca; Torsello, Ferruccio

    2006-01-01

    The safety and effectiveness of full-arch implant-supported fixed partial dentures have been established. Thus, clinicians are now focusing on the treatment modalities that can reduce patient discomfort, treatment time, and cost, and that could enhance the esthetic outcome of the restorations. Full-arch implant-supported rehabilitations are used when the patient is edentulous or if the residual dentition has a poor prognosis. In order to improve patients' comfort and avoid the use of a removable prosthesis, some protocols for immediate replacement of hopeless dentitions have been proposed, but there are no data on their outcomes regarding the soft tissues. The aim of this article is to describe the double provisional technique and to show evidence of its efficacy in easily achieving predictable esthetic results when immediately restoring a hopeless dentition with a fixed implant-supported restoration.

  3. Biowaiver monographs for immediate release solid oral dosage forms: prednisolone.

    Science.gov (United States)

    Vogt, M; Derendorf, H; Krämer, J; Junginger, H E; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2007-01-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing prednisolone are reviewed. Data on its solubility, oral absorption, and permeability are not totally conclusive, but strongly suggest a BCS Class 1 classification. Prednisolone's therapeutic indications and therapeutic index, pharmacokinetics, and the possibility of excipient interactions were also taken into consideration. Available evidence indicates that a biowaiver for IR solid oral dosage forms formulated with the excipients tabulated in this article would be unlikely to expose patients to undue risks.

  4. Assessment of factors affecting on immediate selling behavior

    Directory of Open Access Journals (Sweden)

    abolghasem gholamreza tehrani

    2013-09-01

    Topics in descriptive and inferential statistical analysis of the questionnaire is used. The study of factors influencing buying behavior instantaneously evaluate the effect of component purchase immediate end to help promote marketing in the country has been conducted. Survey of the research and application of research descriptive survey are. Cross-sectional data from a questionnaire survey in 1391 by the city of Karaj passages have been collected from the sale of clothing and apparel. effect between knowledge and intention to purchase the new product is positive. than seven 9 Assumption accepted hypothesis and other hypotheses were rejected

  5. Review of Immediate and Early Loading Protocols in Dental Implants

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    M Rismanchian

    2010-12-01

    Full Text Available Introduction: The concept of treating edentulous patients by osseointegrated implants was first proposed in 1960s. To minimize the failure rate of implants, it has been recommended to keep the implants free of load during the healing period .Recent studies have been directed to achieve faster integration and shorter healing periods prior to implant restoration. Loading protocols (immediate loading , early loading can best be interpreted on the biologic basis of implant integration. Each of these protocols needs special prerequisites and there are special risk factors for different loading protocols. Objectives: In this review article, different loading protocols and their surgical and prosthetic considerations are discussed.

  6. Aesthetic-functional rehabilitation through single restorations: immediate load

    Science.gov (United States)

    BONINO, M.; DE VICO, G.; BAIA, C.; BARLATTANI, A.

    2009-01-01

    SUMMARY In this case report of monoedentulia we will deal with the positioning o fan upper jaw implant in zone 2.6. In such surgery the strategy of a flapless (1, 2) operation with minimum invasive approach has allowed u sto combine both the aesthetic and functionality with an immediate provisional rehabilitation, thus saving recuperation time and trouble for the patient (3). Multidisciplinary character of the execution of this clinical case is underlined, where we associate the knowleadge of conservatori of the prosthetic; always maintaining respect for the canons of gnatology which must not be left out of consideration. PMID:23285348

  7. Hot water always immediately available; Warmwasser stets sofort verfuegbar

    Energy Technology Data Exchange (ETDEWEB)

    Tettamanti, M.

    2007-07-01

    This article describes a system that guarantees the immediate supply of hot water at taps using heating strips that accompany the pipes leading from the boiler to the point of usage whilst avoiding energy losses incurred when hot-water circulation systems are used. The self-regulating system is described and application examples are quoted. The topic of legionella bacteria prevention is discussed and the efficiency of the system is looked at. Notes on the installation of the heating tapes are given and the system's controller is briefly looked at.

  8. The immediate effects of intravenous specific nutrients on EEG sleep.

    Science.gov (United States)

    Lacey, J H; Stanley, P; Hartmann, M; Koval, J; Crisp, A H

    1978-03-01

    This study examined the immediate influence of intravenous amino acids and glucose on sleep as measured by all-night EEG recording. The study on 9 normal female subjects was of a latin-square design. Slow wave sleep (SWS) was increased by both solutions whilst dream sleep (REM) was decreased by amino acids and increased by glucose. Total sleep time was not affected. Subjective feelings as to restlessness, quality and depth of sleep under the impact of the various solutions were gathered. The work further elucidates the effect of nutrition on sleep and supports certain theories as to the function of the main sleep component.

  9. Medical instruments in museums: immediate impressions and historical meanings.

    Science.gov (United States)

    Arnold, Ken; Söderqvist, Thomas

    2011-12-01

    This essay proposes that our understanding of medical instruments might benefit from adding a more forthright concern with their immediate presence to the current historical focus on simply decoding their meanings and context. This approach is applied to the intriguingly tricky question of what actually is meant by a "medical instrument." It is suggested that a pragmatic part of the answer might lie simply in reconsidering the holdings of medical museums, where the significance of the physical actuality of instruments comes readily to hand.

  10. Immediate Implant Loading in Compromised Maxillary Partially Edentulous Arch- A Case Report

    Science.gov (United States)

    Ramesh, Sachhi; Patil, Veena; Jain, Anoop; Gaddale, Reetika

    2014-01-01

    As the aesthetic demands are increasing day by day, demand of immediate restoration or replacement of teeth is also increasing. Because of this, immediate implant placement, along with immediate loading of implant, is a favourite treatment option for patients as well as dentists. This case report discusses the immediate implant loading in compromised maxillary anterior region, in which patient got immediate restoration of edentulous area. More importantly, from the patients’ points of view, immediate loading can produce positive social and psychological effects. PMID:24959519

  11. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin.

    Science.gov (United States)

    Goodarzi, Navid; Barazesh Morgani, Ahmadreza; Abrahamsson, Bertil; Cristofoletti, Rodrigo; Groot, D W; Langguth, Peter; Mehta, Mehul U; Polli, James E; Shah, Vinod P; Dressman, Jennifer B

    2016-04-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release solid oral dosage forms containing ribavirin are reviewed. Ribavirin is highly soluble, but its permeability characteristics are not well defined. Therefore according to the Biopharmaceutical Classification System, and taking a "worst case" approach, ribavirin should be assigned to class III. As ribavirin is transported across the brush border membrane of the human jejunum by hCNT2, it shows saturable uptake in the intestine. However, no common excipients have been shown to compete for ribavirin absorption, nor have problems with BE of immediate release ribavirin formulations containing different excipients and produced by different manufacturing methods been reported in the open literature. So the risk of bioinequivalence caused by these factors appears to be low. Ribavirin is considered a narrow therapeutic index drug, as judged by comparing the minimum effective concentration and minimum toxic concentrations in blood. Although ribavirin would not be eligible for approval via a Biopharmaceutical Classification System-based biowaiver procedure according to today's guidances due to its narrow therapeutic index, the risks of biowaiving should be weighed against the considerable risks associated with studying BE of ribavirin products in healthy subjects.

  12. [Immediate postoperative arrhythmias follwing pneumonectomy for lung cancer].

    Science.gov (United States)

    el Hammami, S; Djilani-Horchani, H; Smati, B; Baccari, S; Marghli, A; Mestiri, T; Kilani, T

    2001-11-01

    Immediate postoperative arrhythmias after pneumonectomy for non small cell lung cancer is a serious complication. Frequency is estimated 10 to 28% of all patients. The goal of this study is to evaluate the incidence of this complication in our experience, preoperative risk factors, therapeutic implications and short outcome. 132 consecutive patients underwent pneumonectomy for lung cancer. We retrospectively studied this series of which 29 patients developed arrhythmias postoperatively. Mean age was 58 years (48 to 79), 16 patients were older than 65 years. Seven patients had medical history of either myocardial infarction or hypertension. Arrhythmias appeared post-operatively on days 1 and 2 six times, days 3 ans 4 ten times, days 5 to 6 six times and days 7 to 10 twice. The trouble consisted in atrial fibrillation in 18 patients, atrial associated with ventricular premature beats in 11 patients. Antiarrhythmic medication (amiodarone) was started as soon as the trouble was confirmed by EKG in all cases. Normalization was obtained in 27 patients (95%). One patient remained dysrrhythmic in spite of treatment. One death occurred on day 4 postoperatively. The mean hospitalisation stay was 10 days. Cardiac arrhythmia in the immediate postoperative course is not rare. Early diagnosis in patients at risk followed by adequat treatment is necessary to avoid haemodynamic storm in these quite fragile patients. Amiodarone is the treatment of choice.

  13. FORMULATION AND DISSOLUTION STUDY OF DILTIAZEM HYDROCHLORIDE IMMEDIATE RELEASE TABLETS

    Directory of Open Access Journals (Sweden)

    BRAHMAIAH BONTHAGARALA

    2014-08-01

    Full Text Available Objective: The main aim and objective of the work is to formulate immediate release tablets using different direct compression vehicles (DCV’S in different ratios. Methods: In the present study, design of oral immediate release tablets of Diltiazem hydrochloride by direct compression technique was carried out. Results: The main motive is to compare the dissolution profile of these formulations and conclude the best formulation which release drug at a faster rate . To determine the best fit dissolution profile for the dosage forms. Diltiazem hydrochloride tablets were formulated by using microcrystalline cellulose (diluent, potato starch, acacia (binder and magnesium stearate (lubricant. The granules were compressed into tablets and were subjected to dissolution studies. The dissolution profile of the formulation F2 was found to have better dissolution rate compared to others. Conclusion: The Invitro dissolution studies of all the formulations were conducted and the results were obtained, it was concluded that formulation F2 was the best with fast release of drug compared to others.

  14. COMPARISON OF PROCEDURES FOR IMMEDIATE CHEMICAL ANALYSIS OF CHARCOAL

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    Artur Queiroz Lana

    2016-04-01

    Full Text Available ABSTRACT The climate change, the quest for sustainability and the strong environmental pressures for alternatives to traditional fossil fuels have increased the interest in the search and use of renewable energy sources. Among them stands out the biomass of charcoal coming from renewable forests, widely used as a thermal reductant in the steel industry in the detriment of the use of mineral coal coke. This study aimed to compare different operating procedures of immediate chemical analysis of charcoal. Seven essays to immediate chemical analysis were compared, spread between procedures performed by Brazilian companies and laboratories, the test described by NBR 8112 and one realized with a thermogravimetric analyzer (TGA using the parameters of the NBR 8112. There were significant differences in the volatiles matter content and consequently in the fixed carbon contents found. The differences between the procedures and the NBR 8112 were caused by an excess burning time, a mass sample above or below the standard or inappropriate container used for burning. It observed that the TGA appraisal of the volatiles content must be carried out with a burning time equal to 2 minutes to obtain results similar to those of the NBR 8112 norm. Moreover, the ash content values were statistically identical and the particles size did not influence the differences between means.

  15. Immediate Weight-Bearing after Ankle Fracture Fixation

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    Reza Firoozabadi

    2015-01-01

    Full Text Available We believe that a certain subset of surgical ankle fracture patients can be made weight-bearing as tolerated immediately following surgery. Immediate weight-bearing as tolerated (IWBAT allows patients to return to ambulation and activities of daily living faster and may facilitate rehabilitation. A prospectively gathered orthopaedic trauma database at a Level 1 trauma center was reviewed retrospectively to identify patients who had ORIF after unstable ankle injuries treated by the senior author. Patients were excluded if they were not IWBAT based on specific criteria or if they did meet followup requirement. Only 1/26 patients was noted to have loss of fixation. This was found at the 6-week followup and was attributed to a missed syndesmotic injury. At 2-week followup, 2 patients had peri-incisional erythema that resolved with a short course of oral antibiotics. At 6-week followup, 20 patients were wearing normal shoes and 6 patients continued to wear the CAM Boot for comfort. To conclude, IWBAT in a certain subset of patients with stable osteosynthesis following an ankle fracture could potentially be a safe alternative to a period of protected weight-bearing.

  16. Psychological coping in the immediate post-abortion period.

    Science.gov (United States)

    Quinley, Kelly E; Ratcliffe, Sarah J; Schreiber, Courtney A

    2014-01-01

    Women undergoing abortion do psychologically well long-term. Little data, however, describe how women fare in the immediate 1-3 day post-abortion period, when interventions may be most impactful for those who need them. We conducted a cohort study of patients undergoing first and second trimester surgical abortion and scored self-reported responses regarding psychological well-being before and after abortion, plus anticipated post-procedural psychological coping. Sixty-two of 148 patients had complete questionnaires. Average predicted psychological scores were 9.7% better than pre-procedural psychological states. Actual psychological coping scores improved by 38% over women's predictions. Women who scored poorly on pre-procedural psychological assessments were more likely to have post-procedural psychosocial concerns (p=0.0376, r=0.2761). While most women approach their abortion with optimism, they actually fare even better psychologically than they predict they will during the 1-3 days following procedures. Poor scores on pre-procedural psychological assessments can identify women in need of additional support in the immediate post-abortion period.

  17. The role of articulatory suppression in immediate false recognition.

    Science.gov (United States)

    Macé, Anne-Laure; Caza, Nicole

    2011-11-01

    False memory for critical lures has been widely documented in long-term memory using the Deese/Roediger-McDermott paradigm. Recent evidence suggests that false memory effects can also be found in short-term memory (STM), supporting models that assume a strong relationship between short-term and long-term memory processes. However, no study has examined the role of articulatory suppression on immediate false memory, even though phono-articulatory factors are critically involved in STM performance and are an intrinsic part of all STM accounts. The current study proposes a novel paradigm to assess false memory effects in a STM task under both silent and articulatory suppression conditions. Using immediate serial recognition, in which participants had to judge whether two successive mixed lists of six associated and non-associated words were matched, we examined true recognition of matching lists and false recognition of mismatching lists comprising a critical lure or unrelated distractor in two experiments. Results from both experiments indicated reduced true recognition of matching lists and greater false serial recognition of mismatching lists comprising a critical lure under articulatory suppression relative to silence. These findings provide further support for some current models of verbal short-term memory, which posit a strong relationship between short-term and long-term memory processes.

  18. Immediate hypersensitivity reactions to penicillins and other betalactams.

    Science.gov (United States)

    Antúnez, C; Martín, E; Cornejo-García, J A; Blanca-Lopez, N; R-Pena, R; Mayorga, C; Torres, M J; Blanca, M

    2006-01-01

    Immediate hypersensitivity reactions to betalactams are IgE mediated and constitute the most frequent allergic reactions mediated by specific immunological mechanisms. IgE responses to benzyl penicillin (BP), the first antibiotic producing the benzyl penicilloyl structure (BPO), are characterized by a quick release of inflammatory mediators, resulting in anaphylactic shock, urticaria and angioedema. With the progressive appearance of other structures, comprising cephalosporins, carbapenems, monobactams and clavulanic acid, IgE selective responses and cross-reactivity reactions were observed. The diagnosis of betalactam hypersensitivity, classically based on skin testing with major and minor determinants of benzyl penicillin or in vitro IgE antibodies to BP, has been modified by the inclusion of different determinants generated from these compounds, for which amoxicillin (AX) is the most relevant, followed by cephalosporins. Some subjects develop positive responses to several betalactams, mostly within the same family, but others develop a selective response. These are relevant for the appropriate selection of antimicrobial drugs in patients who have immediate hypersensitivity to betalactams.

  19. Immediate allergic reaction to methylprednisolone with tolerance of other corticosteroids

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    Atanasković-Marković Marina

    2012-01-01

    Full Text Available Introduction. In spite of the wide usage of corticosteroids for the treatment of a plethora of diseases, sometimes they can induce immediate hypersensitivity reactions, which are however uncommon. Case Outline. We report a case of immediate allergic reaction induced by intravenous methylprednisolone given before operation for surgical repair of an arm contracture as a sequel of burns, which the child had tolerated a month before. Six weeks later the patient repeated the anaphylactic reaction during skin testing to methylprednisolone. In addition, basophile activation test with methylprednisolone (BAT was positive. Conclusion. This case report describes a patient who experienced intraoperative anaphylaxis and anaphylactic reaction induced by skin testing. This is the first report on induction of both anaphylactic reactions by methylprednisolone in the same child. Clinical findings, positive BAT and positive skin tests with methylprednisolone imply that the child developed type-I hypersensitivity. The lack of cross-reactivity with other corticosteroids emphasizes that the reactions were caused by the steroid molecule.

  20. Carga inmediata en implantes dentales Immediate loading of dental implants

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    C. Concejo Cútoli

    2005-10-01

    Full Text Available El protocolo de carga convencional en una o dos fases quirúrgicas ha sido evaluado durante los últimos 30 años bajo todas las condiciones clínicas posibles. En comparación, la carga inmediata es un protocolo relativamente nuevo que necesita de una estricta evaluación clínica. Realizamos una búsqueda bibliográfica sobre los ensayos clínicos publicados de carga inmediata en función de las diferentes opciones terapéuticas que se pueden plantear. Se hallaron resultados comparables para las dos estrategias de carga en mandíbulas edéntulas. Para el tratamiento con prótesis inmediata de maxilares totalmente edéntulos, restauraciones parciales e unitarias es todavía necesaria una selección adecuada de pacientes y un diseño conservador de la prótesis provisional. La necesidad de ensayos clínicos sencillos aleatorizados de doble ciego, con suficiente número de pacientes y adecuado seguimiento, que comparen una determinada situación clínica con un patrón oclusal de la prótesis provisional bien definido, son imprescindibles para acabar de confirmar la seguridad de la técnica.The protocol for conventional loading in one or two surgical stages has been evaluated over the last 30 years under all the possible clinical conditions. By comparison, immediate loading is a relatively new protocol that requires strict clinical evaluation. We conducted a search of the literature published concerning clinical trials on immediate loading according to the different therapeutic options that could be considered. Comparable results were found for both loading strategies in edentulous mandibles. For treatment involving an immediate prosthesis for totally edentulous mandibles, partial and single tooth restorations, patients have to be selected adequately and provisional prostheses have to be designed conservatively. In order to completely confirm the safety of the technique, double-blind, simple, randomized clinical trials have to be carried out with

  1. Influence of isoflurane on Immediate-Early Gene expression

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    Kristopher M Bunting

    2016-01-01

    Full Text Available Background: Anterograde amnesia is a hallmark effect of volatile anesthetics. Isoflurane is known to affect both the translation and transcription of plasticity-associated genes required for normal memory formation in many brain regions. What is not known is whether isoflurane anesthesia prevents the initiation of transcription or whether it halts transcription already in progress. We tested the hypothesis that general anesthesia with isoflurane prevents learning-induced initiation of transcription of several memory-associated immediate-early genes (IEGs correlated with amnesia; we also assessed whether it stops transcription initiated prior to anesthetic administration.Methods: Using a Tone Fear Conditioning paradigm, rats were trained to associate a tone with foot-shock. Animals received either no anesthesia, anesthesia immediately after training, or anesthesia before, during, and after training. Animals were either sacrificed after training or tested 24 hours later for memory. Using Cellular Compartment Analysis of Temporal Activity by Fluorescence in situ Hybridization (catFISH, we examined the percentage of neurons expressing the IEGs Arc/Arg3.1 and Zif268/Egr1/Ngfi-A/Krox-24 in the dorsal hippocampus, primary somatosensory cortex, and primary auditory cortex.Results: On a cellular level, isoflurane administered at high doses (general anesthesia prevented initiation of transcription, but did not stop transcription of Arc and Zif268 mRNA initiated prior to anesthesia. On a behavioral level, the same level of isoflurane anesthesia produced anterograde amnesia for fear conditioning when administered before and during training, but did not produce retrograde amnesia when administered immediately after training. Conclusions: General anesthesia with isoflurane prevents initiation of learning-related transcription but does not stop ongoing transcription of two plasticity-related IEGs, Arc and Zif268, a pattern of disruption that parallels the

  2. TEC enhancement immediately before M9 mega-thrust earthquakes

    Science.gov (United States)

    Heki, Kosuke

    2012-07-01

    Earthquakes are often preceded by electromagnetic precursors, e.g. electric currents in the ground and propagation anomalies of radio waves. By monitoring the differences of the L1 and L2 carrier phases from GPS satellites, we can infer ionospheric Total Electron Content (TEC). Here I report that positive anomalies of ionospheric TEC appeared immediately before the 2011 Tohoku-Oki (Mw9.0), 2010 Chile (Maule) (Mw8.8), 2007 Bengkulu (Mw8.6), and 2004 Sumatra-Andaman (Mw9.2) earthquakes. Coseismic vertical movements of the surface excite acoustic and internal gravity waves, causing coseismic ionospheric disturbances (CID), and GPS-TEC data showed that they occurred about ten minutes after these earthquakes. In addition to them, positive TEC anomalies were found to start 60-40 minutes before these earthquakes above the focal regions, and to last until the onsets of CID. In the Tohoku-Oki case, the anomaly was reached about one tenth of the background TEC immediately before the earthquake. TEC enhancements often occur irrespective of earthquakes, for example, sudden increase of TEC due to solar flares and large-scale traveling ionospheric disturbances (LSTID) propagating from the auroral oval to mid-latitude regions. These disturbances can be distinguished by carefully observing their spatial extents and movements. Geomagnetic activities were relatively high in the 2004 Sumatra-Andaman and 2011 Tohoku-Oki events, but were low in the 2007 Bengkulu and 2010 Chile events. For the Tohoku-Oki and the Bengkulu earthquakes, we analyzed the TEC time series of the same satellite and receiver pair over 120 days before and after the earthquakes, and confirmed that the precursory anomalies of the earthquakes were the largest in these periods. We also investigated three M8 class earthquakes, the 1994 Hokkaido-Toho-Oki (Mw8.3), 2006 Kuril (Mw8.2), and the 2003 Tokachi-Oki (Mw8.0) earthquakes. However, only weak precursory TEC anomalies were seen in the 1994 event, and not in the 2003

  3. The Effect of D-Cycloserine on Immediate vs. Delayed Extinction of Learned Fear

    Science.gov (United States)

    Langton, Julia M.; Richardson, Rick

    2010-01-01

    We compared the effect of D-cycloserine (DCS) on immediate (10 min after conditioning) and delayed (24 h after conditioning) extinction of learned fear in rats. DCS facilitated both immediate and delayed extinction when the drug was administered after extinction training. However, DCS did not facilitate immediate extinction when administered prior…

  4. 9 CFR 93.316 - Horses from Canada for immediate slaughter.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Horses from Canada for immediate...; REQUIREMENTS FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Horses Canada 16 § 93.316 Horses from Canada for immediate slaughter. Horses imported from Canada for immediate slaughter shall be consigned from the port...

  5. 19 CFR 142.21 - Merchandise eligible for special permit for immediate delivery.

    Science.gov (United States)

    2010-04-01

    ... immediate delivery. 142.21 Section 142.21 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) ENTRY PROCESS Special Permit for Immediate Delivery § 142.21 Merchandise eligible for special permit for immediate delivery. Merchandise may be...

  6. 77 FR 19901 - Provisional Unlawful Presence Waivers of Inadmissibility for Certain Immediate Relatives

    Science.gov (United States)

    2012-04-02

    ... process, often causing U.S. citizens to be separated for extended periods from their immediate relatives... Under the current system, the entire waiver adjudication process occurs while the immediate relative... with an immediate relative immigrant visa application.\\3\\ The notice explained the proposed process...

  7. 19 CFR 142.22 - Application for special permit for immediate delivery.

    Science.gov (United States)

    2010-04-01

    ... SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) ENTRY PROCESS Special Permit for Immediate Delivery § 142.22 Application for special permit for immediate delivery. (a) Form. An application for a special... 19 Customs Duties 2 2010-04-01 2010-04-01 false Application for special permit for immediate...

  8. 77 FR 8310 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2012-02-14

    ... 4, 2012), 77 FR 1532 (January 10, 2012) (SR-Phlx-2011-185) (notice of filing and immediate..., 2011), 76 FR 78322 (December 16, 2011) (SR-Phlx-2011-162) (notice of filing and immediate effectiveness... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate...

  9. Social dilemma alleviated by sharing the gains with immediate neighbors

    CERN Document Server

    Wu, Zhi-Xi

    2014-01-01

    We study the evolution of cooperation in the evolutionary spatial prisoner's dilemma game (PDG) and snowdrift game (SG), within which a fraction $\\alpha$ of the payoffs of each player gained from direct game interactions is shared equally by the immediate neighbors. The magnitude of the parameter $\\alpha$ therefore characterizes the degree of the relatedness among the neighboring players. By means of extensive Monte Carlo simulations as well as an extended mean-field approximation method, we trace the frequency of cooperation in the stationary state. We find that plugging into relatedness can significantly promote the evolution of cooperation in the context of both studied games. Unexpectedly, cooperation can be more readily established in the spatial PDG than that in the spatial SG, given that the degree of relatedness and the cost-to-benefit ratio of mutual cooperation are properly formulated. The relevance of our model with the stakeholder theory is also briefly discussed.

  10. Biowaiver monographs for immediate release solid oral dosage forms: prednisone.

    Science.gov (United States)

    Vogt, M; Derendorf, H; Krämer, J; Junginger, H E; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2007-06-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing prednisone are reviewed. Due to insufficient data prednisone cannot be definitively classified according to the current Biopharmaceutics Classification System (BCS) criteria as both the solubility and the permeability of prednisone are on the borderline of the present criteria of BCS Class I. Prednisone's therapeutic indications and therapeutic index, pharmacokinetics and the possibility of excipient interactions were also taken into consideration. Available evidence indicates that a biowaiver for IR solid oral dosage forms formulated with the excipients tabulated in this article would be unlikely to expose patients to undue risks.

  11. Biowaiver monographs for immediate release solid oral dosage forms: cimetidine.

    Science.gov (United States)

    Jantratid, E; Prakongpan, S; Dressman, J B; Amidon, G L; Junginger, H E; Midha, K K; Barends, D M

    2006-05-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing cimetidine are reviewed. According to the current Biopharmaceutics Classification System (BCS), cimetidine would be assigned to Class III. Cimetidine's therapeutic use and therapeutic index, its pharmacokinetic properties, data related to the possibility of excipient interactions, and reported BE/bioavailability (BA) problems were also taken into consideration. On the basis of the overall evidence, a biowaiver can be recommended for cimetidine IR products, provided that the test product contains only those excipients reported in this paper in their usual amounts, and that the test and the comparator drug products both are "rapidly dissolving" as per BCS.

  12. Biowaiver monographs for immediate release solid oral dosage forms: furosemide.

    Science.gov (United States)

    Granero, G E; Longhi, M R; Mora, M J; Junginger, H E; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2010-06-01

    Literature and new experimental data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing furosemide are reviewed. The available data on solubility, oral absorption, and permeability are sufficiently conclusive to classify furosemide into Class IV of the Biopharmaceutics Classification System (BCS). Furosemide's therapeutic use and therapeutic index, its pharmacokinetic properties, data related to the possibility of excipient interactions and reported BE/bioavailability (BA) problems are also taken into consideration. In view of the data available, it is concluded that the biowaiver procedure cannot be justified for either the registration of new multisource drug products or major postapproval changes (variations) to existing drug products.

  13. Biowaiver monographs for immediate release solid oral dosage forms: ibuprofen.

    Science.gov (United States)

    Potthast, H; Dressman, J B; Junginger, H E; Midha, K K; Oeser, H; Shah, V P; Vogelpoel, H; Barends, D M

    2005-10-01

    Literature data are reviewed on the properties of ibuprofen related to the biopharmaceutics classification system (BCS). Ibuprofen was assessed to be a BCS class II drug. Differences in composition and/or manufacturing procedures were reported to have an effect on the rate, but not the extent of absorption; such differences are likely to be detectable by comparative in vitro dissolution tests. Also in view of its therapeutic use, its wide therapeutic index and uncomplicated pharmacokinetic properties, a biowaiver for immediate release (IR) ibuprofen solid oral drug products is scientifically justified, provided that the test product contains only those excipients reported in this paper in their usual amounts, the dosage form is rapidly dissolving (85% in 30 min or less) in buffer pH 6.8 and the test product also exhibits similar dissolution profiles to the reference product in buffer pH 1.2, 4.5, and 6.8.

  14. Biowaiver monographs for immediate release solid oral dosage forms: acetazolamide.

    Science.gov (United States)

    Granero, G E; Longhi, M R; Becker, C; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2008-09-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing acetazolamide are reviewed. Acetazolamide's solubility and permeability characteristics according to the Biopharmaceutics Classification System (BCS), as well as its therapeutic use and therapeutic index, its pharmacokinetic properties, data related to the possibility of excipient interactions and reported BE/bioavailability (BA) problems are taken into consideration. The available data on solubility, on oral absorption and permeability are not sufficiently conclusive to classify acetazolamide with certainty. Taking a conservative approach, no biowaiver is considered justified for the registration of new multisource drug products. However, SUPAC level 1 and level 2 postapproval changes and most EU Type I variations can be approved waiving in vivo BE studies.

  15. Hemimaxillectomy for desmoplastic ameloblastoma with immediate temporalis flap reconstruction.

    Science.gov (United States)

    Elo, Jeffrey A; Tandon, Rahul; Allen, Chad N; Murray, Matthew D

    2014-08-01

    Ameloblastoma is one of the most common odontogenic tumors encountered, occurring more frequently than all other tumors combined, if one excludes the keratocystic odontogenic tumor. These tumors can cause severe expansion of the cortical bones and gross anatomic deformities. They can affect the dentition, causing tooth mobility and displacement. Fortunately, morbidity can be minimized with recognition on routine radiographic examination. The tissue may be unilocular or multilocular and has been described as having a "soap-bubble" appearance. Nevertheless, its radiographic appearance is insufficient to make a definitive diagnosis, because other tumors have similar appearance. Although the anatomic distribution and progression of ameloblastoma remain fairly consistent, alternative manifestations follow an atypical clinical course. One such variant is the desmoplastic ameloblastoma. We present a case of maxillary desmoplastic ameloblastoma treated with hemimaxillectomy and immediate reconstruction with temporalis flap that was recurrence-free at 36 months. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. Nano hemostat solution: immediate hemostasis at the nanoscale.

    Science.gov (United States)

    Ellis-Behnke, Rutledge G; Liang, Yu-Xiang; Tay, David K C; Kau, Phillis W F; Schneider, Gerald E; Zhang, Shuguang; Wu, Wutian; So, Kwok-Fai

    2006-12-01

    Hemostasis is a major problem in surgical procedures and after major trauma. There are few effective methods to stop bleeding without causing secondary damage. We used a self-assembling peptide that establishes a nanofiber barrier to achieve complete hemostasis immediately when applied directly to a wound in the brain, spinal cord, femoral artery, liver, or skin of mammals. This novel therapy stops bleeding without the use of pressure, cauterization, vasoconstriction, coagulation, or cross-linked adhesives. The self-assembling solution is nontoxic and nonimmunogenic, and the breakdown products are amino acids, which are tissue building blocks that can be used to repair the site of injury. Here we report the first use of nanotechnology to achieve complete hemostasis in less than 15 seconds, which could fundamentally change how much blood is needed during surgery of the future.

  17. Pros and cons of immediately sequential bilateral cataract surgery (ISBCS).

    Science.gov (United States)

    Grzybowski, Andrzej; Wasinska-Borowiec, Weronika; Claoué, Charles

    2016-01-01

    Immediately sequential bilateral cataract surgery (ISBCS) is currently a "hot topic" in ophthalmology. There are well-documented advantages in terms of quicker visual rehabilitation and reduced costs. The risk of bilateral simultaneous endophthalmitis and bilateral blindness is now recognized to be minuscule with the advent of intracameral antibiotics and modern management of endophthalmitis. Refractive surprises are rare for normal eyes and with the use of optical biometry. Where a general anesthetic is indicated for cataract surgery, the risk of death from a second anesthetic is much higher than the risk of blindness. A widely recognized protocol from the International Society of Bilateral Cataract Surgeons needs to be adhered to if surgeons wish to start practicing ISBCS.

  18. Integrated Testlets and the Immediate Feedback Assessment Technique

    CERN Document Server

    Slepkov, Aaron D

    2013-01-01

    The increased use of multiple-choice (MC) questions in introductory-level physics final exams is largely hindered by reservations about its ability to test the broad cognitive domain that is routinely accessed with typical constructed-response (CR) questions. Thus, there is a need to explore ways in which MC questions can be utilized pedagogically more like CR questions while maintaining their attendant procedural advantages. we describe how an answer-until-correct MC response format allows for the construction of multiple-choice examinations designed to operate much as a hybrid between standard MC and CR testing. With this tool - the immediate feedback assessment technique (IF-AT) - students gain complete knowledge of the correct answer for each question during the examination, and can use such information for solving subsequent test items. This feature allows for the creation of a new type of context-dependent item sets; the "integrated testlet". In an integrated testlet certain items are purposefully inter...

  19. Management of intrusive luxation with immediate surgical repositioning

    Directory of Open Access Journals (Sweden)

    Mazumdar Dibyendu

    2009-01-01

    Full Text Available Intrusive luxation is one of the most severe forms of traumatic injuries in which the affected tooth is forced to displace deeper into the alveolus. As a consequence of this type of injury, maximum damage occurs to the pulp and all the supporting structures. This report presents a case of severe intrusive luxation of mature maxillary central and lateral incisor in a 40-year-old male. The intruded tooth was immediately repositioned (surgical extrusion and splinted within hours following injury. Antibiotic therapy was initiated at the time of repositioning and maintained for 5 days. Pulp removal and calcium hydroxide treatment of the root canal was carried out after repositioning. Splint was removed 2 months later. Definitive root canal treatment with Gutta percha was accomplished at a later appointment. Clinical and radiographic examination 6, 12 and 24 months after the surgical extrusion revealed satisfactory progressive apical and periodontal healing.

  20. Immediate allergic and nonallergic reactions to Christmas and Easter cacti

    DEFF Research Database (Denmark)

    Andersen, F; Bindslev-Jensen, C; Stahl Skov, P;

    1999-01-01

    BACKGROUND: Occupational exposure to Christmas cacti has been reported as a cause of type I allergy. Therefore, the prevalence of immediate-type mucosal and skin reactions related to cactus exposure was studied in 103 employees in a cactus nursery. METHODS: The study was based on a questionnaire...... followed by clinical examination, skin prick tests (SPT) with standard inhalant allergens and cacti, and a histamine-release test (HRT/Refix) using fresh cactus extracts as elicitor. RESULTS: The questionnaire was answered by 84 (82%) of the nursery employees, and 63 (61%) were interviewed and skin prick...... tested; 58 of these were tested with HRT/Refix. Furthermore, 22 healthy controls were included and tested in vivo and in vitro. Cactus-related contact urticaria and/or rhinoconjunctivitis were reported by 37% of the cactus workers. Based on a combination of positive history, positive SPT, and positive...

  1. Immediate versus delayed postpartum insertion of contraceptive implant for contraception.

    Science.gov (United States)

    Sothornwit, Jen; Werawatakul, Yuthapong; Kaewrudee, Srinaree; Lumbiganon, Pisake; Laopaiboon, Malinee

    2017-04-22

    The spacing of pregnancies has a positive impact on maternal and newborn health. The progestin contraceptive implant, which is a long-acting, reversible method of contraception, has a well-established low failure rate that is compatible with tubal sterilization. The standard provision of contraceptive methods on the first postpartum visit may put some women at risk of unintended pregnancy, either due to loss to follow-up or having sexual intercourse prior to receiving contraception. Therefore, the immediate administration of contraception prior to discharge from the hospital that has high efficacy may improve contraceptive prevalence and prevent unintended pregnancy. To compare the initiation rate, effectiveness, and side effects of immediate versus delayed postpartum insertion of implant for contraception. We searched for eligible studies up to 28 October 2016 in the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, and POPLINE. We examined review articles and contacted investigators. We also checked registers of ongoing clinical trials, citation lists of included studies, key textbooks, grey literature, and previous systematic reviews for potentially relevant studies. We sought randomised controlled trials (RCTs) that compared immediate postpartum versus delayed insertion of contraceptive implant for contraception. Two review authors (JS, YW) independently screened titles and abstracts of the search results, and assessed the full-text articles of potentially relevant studies for inclusion. They extracted data from the included studies, assessed risk of bias, compared results, and resolved disagreements by consulting a third review author (PL or SK). We contacted investigators for additional data, where possible. We computed the Mantel-Haenszel risk ratio (RR) with 95% confidence interval (CI) for binary outcomes and the mean difference (MD) with 95% CI for continuous variables. Three studies that included 410 participants met the

  2. Examining the Relationship between Immediate Serial Recall and Immediate Free Recall: Common Effects of Phonological Loop Variables but Only Limited Evidence for the Phonological Loop

    Science.gov (United States)

    Spurgeon, Jessica; Ward, Geoff; Matthews, William J.

    2014-01-01

    We examined the contribution of the phonological loop to immediate free recall (IFR) and immediate serial recall (ISR) of lists of between one and 15 words. Following Baddeley (1986, 2000, 2007, 2012), we assumed that visual words could be recoded into the phonological store when presented silently but that recoding would be prevented by…

  3. IMMEDIATE COMPLICATIONS AFTER 88 HEPATECTOMIES - BRAZILIAN CONSECUTIVE SERIES.

    Science.gov (United States)

    Amico, Enio Campos; Alves, José Roberto; João, Samir Assi; Guimarães, Priscila Luana Franco Costa; Medeiros, Joafran Alexandre Costa de; Barreto, Élio José Silveira da Silva

    2016-01-01

    Hepatectomies have been increasingly recommended and performed in Brazil; they present great differences related to immediate complications. Assessing the immediate postoperative complications in a series of 88 open liver resections. Prospective database of patients subjected to consecutive hepatectomies over nine years. The post-hepatectomy complications were categorized according to the Clavien-Dindo classification; complications presenting grade equal to or greater than 3 were considered major complications. Hepatic resections involving three or more resected liver segments were considered major hepatectomies. Eighty-four patients were subjected to 88 hepatectomies, mostly were minor liver resections (50 cases, 56.8%). Most patients had malignant diseases (63 cases; 71.6%). The mean hospitalization time was 10.9 days (4-43). Overall morbidity and mortality rates were 37.5% and 6.8%, respectively. The two most common immediate general complications were intra-peritoneal collections (12.5%) and pleural effusion (12.5%). Bleeding, biliary fistula and liver failure were identified in 6.8%, 4.5% and 1.1% of the cases, respectively, among the hepatectomy-specific complications. The patients operated in the second half of the series showed better results, which were apparently influenced by the increased surgical expertise, by the modification of the hepatic parenchyma section method and by the increased organ preservation. No Brasil as hepatectomias têm sido cada vez mais indicadas e realizadas, apresentando grandes diferenças relacionadas às complicações imediatas. Avaliar as complicações pós-operatórias imediatas em uma série de 88 ressecções hepáticas abertas. Foi utilizada uma base de dados prospectiva de pacientes submetidos à hepatectomias consecutivas em nove anos. As complicações pós-hepatectomia seguiram a Classificação de Clavien-Dindo, sendo consideradas complicações maiores aquelas as quais apresentaram grau igual ou maior que 3. Foram

  4. Immediate effect of intravitreal injection of bevacizumab on intraocular pressure

    Directory of Open Access Journals (Sweden)

    Lemos-Reis R

    2014-07-01

    Full Text Available Ricardo Lemos-Reis,1 Nuno Moreira-Gonçalves,1 António B Melo,1 Ângela M Carneiro,1,2 Fernando M Falcão-Reis1,2 1Department of Ophthalmology of Hospital de São João, Porto, Portugal; 2Department of Sense Organs, Faculty of Medicine, University of Porto, Porto, Portugal Purpose: To investigate the immediate effect of intravitreal injection of bevacizumab on intraocular pressure (IOP. Methods: This was a prospective and nonrandomized study. A total of 291 eyes with macular edema or active choroidal neovascularization were submitted to a single 1.25 mg (0.05 mL bevacizumab intravitreal injection. Intraocular pressure was measured with an Icare® tonometer immediately before and after injection in a seated position. The presence of subconjunctival reflux was recorded. The fellow eye served as the control.Results: Mean preoperative IOP was 18.0±5.9 mmHg in the treated eye versus 16.9±6.0 mmHg in the fellow eye. Mean postoperative IOP was 42.1±14.5 mmHg in the treated eye versus 17.5±6.0 mmHg in the fellow eye. The IOP variation was statistically significant in both cases and controls (P<0.001 and P=0.003, respectively, and this increase was higher in cases than in controls (P<0.001. Postoperative IOPs higher than 50 mmHg were achieved in 32.0% of the eyes. Subconjunctival reflux was present in 21.3% and determined a lower IOP rise (P<0.001. Tested variables (glaucoma, phakic status, and sex did not have a statistically significant effect on IOP rise or subconjunctival reflux. Conclusion: IOP increases with intravitreal bevacizumab injection, reaching 50 mmHg or more in about one third of patients. A higher IOP is expected if no subconjunctival reflux occurs. The baseline IOP does not influence the incidence of subconjunctival reflux. The clinical relevance of these facts has yet to be clarified. Keywords: bevacizumab, intraocular pressure, intravitreal injection, Icare®

  5. Biowaiver monographs for immediate release solid oral dosage forms: rifampicin.

    Science.gov (United States)

    Becker, C; Dressman, J B; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Barends, D M

    2009-07-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of new multisource and reformulated immediate release (IR) solid oral dosage forms containing rifampicin as the only Active Pharmaceutical Ingredient (API) are reviewed. Rifampicin's solubility and permeability, its therapeutic use and index, pharmacokinetics, excipient interactions and reported BE/bioavailability (BA) problems were taken into consideration. Solubility and absolute BA data indicate that rifampicin is a BCS Class II drug. Of special concern for biowaiving is that many reports of failure of IR solid oral dosage forms of rifampicin to meet BE have been published and the reasons for these failures are yet insufficiently understood. Moreover, no reports were identified in which in vitro dissolution was shown to be predictive of nonequivalence among products. Therefore, a biowaiver based approval of rifampicin containing IR solid oral dosage forms cannot be recommended for either new multisource drug products or for major scale-up and postapproval changes (variations) to existing drug products.

  6. Biowaiver monographs for immediate release solid oral dosage forms: efavirenz.

    Science.gov (United States)

    Cristofoletti, Rodrigo; Nair, Anita; Abrahamsson, Bertil; Groot, D W; Kopp, Sabine; Langguth, Peter; Polli, James E; Shah, Vinod P; Dressman, Jennifer B

    2013-02-01

    Literature data pertaining to the decision to allow a waiver of in vivo bioequivalence testing for the approval of immediate-release (IR) solid oral dosage forms containing efavirenz as the only active pharmaceutical ingredient (API) are reviewed. Because of lack of conclusive data about efavirenz's permeability and its failure to comply with the "high solubility" criteria according to the Biopharmaceutics Classification System (BCS), the API can be classified as BCS Class II/IV. In line with the solubility characteristics, the innovator product does not meet the dissolution criteria for a "rapidly dissolving product." Furthermore, product variations containing commonly used excipients or in the manufacturing process have been reported to impact the rate and extent of efavirenz absorption. Despite its wide therapeutic index, subtherapeutic levels of efavirenz can lead to treatment failure and also facilitate the emergence of efavirenz-resistant mutants. For all these reasons, a biowaiver for IR solid oral dosage forms containing efavirenz as the sole API is not scientifically justified for reformulated or multisource drug products.

  7. Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Levetiracetam.

    Science.gov (United States)

    Petruševska, Marija; Berglez, Sandra; Krisch, Igor; Legen, Igor; Megušar, Klara; Peternel, Luka; Abrahamsson, Bertil; Cristofoletti, Rodrigo; Groot, D W; Kopp, Sabine; Langguth, Peter; Mehta, Mehul; Polli, James E; Shah, Vinod P; Dressman, Jennifer

    2015-09-01

    Literature and experimental data relevant for the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing levetiracetam are reviewed. Data on solubility and permeability suggest that levetiracetam belongs to class I of the biopharmaceutical classification system (BCS). Levetiracetam's therapeutic use, its wide therapeutic index, and its favorable pharmacokinetic properties make levetiracetam a valid candidate for the BCS-based biowaiver approach. Further, no BE studies with levetiracetam IR formulations in which the test formulation failed to show BE with the comparator have been reported in the open literature. On the basis of the overall evidence, it appears unlikely that a BCS-based biowaiver approach for levetiracetam IR solid oral dosage forms formulated with established excipients would expose patients to undue risks. Thus, the BCS-based biowaiver approach procedure is recommended for IR solid oral dosage form containing levetiracetam, provided the excipients in the formulation are also present in products that have been approved in countries belonging to or associated with the International Committee on Harmonization and are used in their usual quantities, and provided the dissolution profiles of the test and reference product comply with the current requirements for BCS-based biowaivers.

  8. Biowaiver monographs for immediate release solid oral dosage forms: isoniazid.

    Science.gov (United States)

    Becker, C; Dressman, J B; Amidon, G L; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Barends, D M

    2007-03-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing isoniazid as the only active pharmaceutical ingredient (API) are reviewed. Isoniazid's solubility and permeability characteristics according to the Biopharmaceutics Classification System (BCS), as well as its therapeutic use and therapeutic index, its pharmacokinetic properties, data related to the possibility of excipient interactions and reported BE/bioavailability (BA) problems were taken into consideration. Isoniazid is "highly soluble" but data on its oral absorption and permeability are inconclusive, suggesting this API to be on the borderline of BCS Class I and III. For a number of excipients, an interaction with the permeability is extreme unlikely, but lactose and other deoxidizing saccharides can form condensation products with isoniazid, which may be less permeable than the free API. A biowaiver is recommended for IR solid oral drug products containing isoniazid as the sole API, provided that the test product meets the WHO requirements for "very rapidly dissolving" and contains only the excipients commonly used in isoniazid products, as listed in this article. Lactose and/or other deoxidizing saccharides containing formulations should be subjected to an in vivo BE study.

  9. Biowaiver monographs for immediate release solid oral dosage forms: levofloxacin.

    Science.gov (United States)

    Koeppe, Marcelle O; Cristofoletti, Rodrigo; Fernandes, Eduardo F; Storpirtis, Silvia; Junginger, Hans E; Kopp, Sabine; Midha, Kamal K; Shah, Vinod P; Stavchansky, Salomon; Dressman, Jennifer B; Barends, Dirk M

    2011-05-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing levofloxacin as the only active pharmaceutical ingredient (API) are reviewed. According to the current Biopharmaceutics Classification System, levofloxacin can be assigned to Class I. No problems with BE of IR levofloxacin formulations containing different excipients and produced by different manufacturing methods have been reported and hence the risk of bioinequivalence caused by these factors appears to be low. In addition, levofloxacin has a wide therapeutic index. On the basis of this evidence, a biowaiver is recommended for IR solid oral dosage forms containing levofloxacin as the single API provided that (a) the test product contains only excipients present in IR levofloxacin drug products that have been approved in International Conference on Harmonization (ICH) or associated countries and which have the same dosage form; (b) both the test and comparator dosage form are "very rapidly dissolving" or "rapidly dissolving" with similarity of the dissolution profiles demonstrated at pH 1.2, 4.5, and 6.8; and (c) if the test product contains polysorbates, it should be both qualitatively and quantitatively identical to its comparator in terms of polysorbate content.

  10. Biowaiver monographs for immediate release solid oral dosage forms: metronidazole.

    Science.gov (United States)

    Rediguieri, Camila F; Porta, Valentina; G Nunes, Diana S; Nunes, Taina M; Junginger, Hans E; Kopp, Sabine; Midha, Kamal K; Shah, Vinod P; Stavchansky, Salomon; Dressman, Jennifer B; Barends, Dirk M

    2011-05-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing metronidazole are reviewed. Metronidazole can be assigned to Biopharmaceutics Classification System Class I. Most BE studies that were identified reported the investigated formulations to be bioequivalent, indicating the risk of bioinequivalence to be low. Formulations showing differences in bioavailability showed dissimilarities in in vitro dissolution profiles. Furthermore, metronidazole has a wide therapeutic index. It is concluded that a biowaiver for solid IR formulations is justified, provided: (a) the test product and its comparator are both rapidly dissolving; (b) meet similarity of the dissolution profiles at pH 1.2, 4.5, and 6.8; (c) the test product contains only excipients present in IR drug products approved in International Conference on Harmonisation (ICH) or associated countries in the same dosage form; and (d) if the test product contains sorbitol, sodium laurilsulfate, or propylene glycol, the test product needs to be qualitatively and quantitatively identical to its comparator with respect to these excipients [corrected]..

  11. Biowaiver monographs for immediate release solid oral dosage forms: aciclovir.

    Science.gov (United States)

    Arnal, J; Gonzalez-Alvarez, I; Bermejo, M; Amidon, G L; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Dressman, J B; Barends, D M

    2008-12-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing (biowaiver) for the approval of immediate release (IR) solid oral dosage forms containing aciclovir are reviewed. Aciclovir therapeutic use and therapeutic index, pharmacokinetic properties, data related to the possibility of excipient interactions and reported BE/bioavailability (BA) studies were also taken into consideration in order to ascertain whether a biowaiver can be recommended. According to the Biopharmaceutics Classification System (BCS) and considering tablet strengths up to 400 mg, aciclovir would be BCS Class III. However, in some countries also 800 mg tablets are available which fall just within BCS Class IV. Aciclovir seems not to be critical with respect to a risk for bioinequivalence, as no examples of bioinequivalence have been identified. It has a wide therapeutic index and is not used for critical indications. Hence, if: (a) the test product contains only excipients present in aciclovir solid oral IR drug products approved in ICH or associated countries, for instance as presented in this article; and (b) the comparator and the test product both are very rapidly dissolving, a biowaiver for IR aciclovir solid oral drug products is considered justified for all tablet strengths.

  12. Biowaiver monographs for immediate release solid oral dosage forms: pyrazinamide.

    Science.gov (United States)

    Becker, C; Dressman, J B; Amidon, G L; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Barends, D M

    2008-09-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing pyrazinamide as the only active pharmaceutical ingredient (API) are reviewed. Pyrazinamide is BCS Class III, with linear absorption over a wide dosing range. The risk of bioinequivalence is estimated to be low. Depending on the definition used, pyrazinamide can be classified as a narrow therapeutic index (NTI) drug, which is usually a caveat to biowaiving but may be deemed acceptable if the Summary of Product Characteristics (SmPCs) of the test product stipulates the need for regular monitoring of liver function. It is concluded that a biowaiver can be recommended for IR solid oral dosage only when the test product (a) contains only excipients present in pyrazinamide IR solid oral drug products approved in ICH or associated countries, (b) these excipients are present in amounts normally used in IR solid oral dosage forms, (c) the test product is very rapidly dissolving, (d) the SmPC of the test product indicates the need for monitoring of the patient's liver function.

  13. Biowaiver monographs for immediate release solid oral dosage forms: lamivudine.

    Science.gov (United States)

    Strauch, S; Jantratid, E; Dressman, J B; Junginger, H E; Kopp, S; Midha, K K; Shah, V P; Stavchansky, S; Barends, D M

    2011-06-01

    Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing lamivudine as the only active pharmaceutical ingredient were reviewed. The solubility and permeability data of lamivudine as well as its therapeutic index, its pharmacokinetic properties, data indicating excipient interactions, and reported BE/bioavailability (BA) studies were taken into consideration. Lamivudine is highly soluble, but its permeability characteristics are not well-defined. Reported BA values in adults ranged from 82% to 88%. Therefore, lamivudine is assigned to the biopharmaceutics classification system (BCS) class III, noting that its permeability characteristics are near the border of BCS class I. Lamivudine is not a narrow therapeutic index drug. Provided that (a) the test product contains only excipients present in lamivudine IR solid oral drug products approved in the International Conference on Harmonization or associated countries in usual amounts and (b) the test product as well as the comparator product fulfills the BCS dissolution criteria for very rapidly dissolving; a biowaiver can be recommended for new lamivudine multisource IR products and major post-approval changes of marketed drug products.

  14. [Progress in immediate breast reconstruction with skin sparing mastectomy].

    Science.gov (United States)

    Garbay, J-R; Saouma, S; Marsiglia, H

    2008-04-01

    Skin sparing mastectomy (SSM) and subcutaneous mastectomy (SCM) are recent techniques. They are always associated with immediate breast reconstruction (IBR). Their safety from an oncologic point of view and indications are of great concern. In early breast cancer, SSM and SCM are associated with the same risk of local recurrence as a modified radical mastectomy, when correctly indicated. This has been validated by numerous studies. In these non-randomised studies, overall survival cannot be evaluated. Such techniques can now be validated in the oncologic setting when correctly indicated and when decision-making is always concerted and multidisciplinary. Skin-sparing techniques are obviously associated with better cosmetic results than secondary reconstructions. Thus SSM with IBR are ideally indicated for ductal carcinoma in situ, pure infiltrating or mixed carcinomas requiring mastectomy without subsequent radiotherapy. The selection criterion of no postoperative radiotherapy allows the right candidates to be chosen for SSM. But often this criterion cannot be obtained preoperatively. In such cases, performing a two-step operation could be a good option. The interval between operations can be used by the patient to obtain more information and to make a mature decision regarding her choice of treatment. It seems essential to be able to offer every patient SSM with IBR which are validated standardised indications. Such is not the case everywhere in France today. The organisation of primary care through professional networks should provide us with an opportunity to fulfil these needs.

  15. The Immediate Results of Surgical Treatment of Bladder Cancer

    Directory of Open Access Journals (Sweden)

    Alexei L. Charyshkin

    2016-06-01

    Full Text Available The objective of this study was to evaluate the immediate results of the use of ureterointestinal anastomosis according to the Bricker technique at radical cystectomy (RC for bladder cancer (BC. Materials and Results: The study included 96 patients (11.5% women and 88.5% men with bladder cancer (BC, aged from 31 to 74 years (mean age 63.8±7.2, who underwent RC in the Lipetsk Regional Oncology Center, in the period from 2005 to 2014. Among the early postoperative complications, we identified dynamic ileus (16.7%, inflammatory complications of the surgical wound (12.5%, acute pyelonephritis (10.4%, and failure of ureterointestinal anastomosis (4.2%. The frequency of postoperative acute pyelonephritis corresponded to the findings of other authors. Two (2.1% patients died from early postoperative complications because of concomitant diseases (ischemic heart disease, myocardial infarction; thus, postoperative mortality in the early postoperative period was 4.2%. Chronic pyelonephritis with chronic renal failure detected in 15(15.6% patients after one year after surgery was the most frequent late postoperative complication. The stricture of ureterointestinal anastomosis in 9(9.4% patients has been eliminated through relaparotomy and resection of anastomosis. The development of urolithiasis in 12(12.5% patients after one year after surgery has required the implementation of contact lithotripsy and litholytic therapy.

  16. Immediate transfer of synesthesia to a novel inducer.

    Science.gov (United States)

    Mroczko, Aleksandra; Metzinger, Thomas; Singer, Wolf; Nikolić, Danko

    2009-11-30

    In synesthesia, a certain stimulus (e.g. grapheme) is associated automatically and consistently with a stable perceptual-like experience (e.g. color). These associations are acquired in early childhood and remain robust throughout the lifetime. Synesthetic associations can transfer to novel inducers in adulthood as one learns a second language that uses another writing system. However, it is not known how long this transfer takes. We found that grapheme-color associations can transfer to novel graphemes after only a 10-minute writing exercise. Most subjects experienced synesthetic associations immediately after learning a new Glagolitic grapheme. Using a Stroop task, we provide objective evidence for the creation of novel associations between the newly learned graphemes and synesthetic colors. Also, these associations generalized to graphemes handwritten by another person. The fast learning process and the generalization suggest that synesthesia begins at the semantic level of representation with the activation of a certain concept (the inducer), which then, uniquely for the synesthetes, activates representations at the perceptual level (the concurrent). Thus, the results imply that synesthesia is a much more flexible and plastic phenomenon than has been believed until now.

  17. Diagnosis and management of immediate hypersensitivity reactions to cephalosporins.

    Science.gov (United States)

    Dickson, Scott D; Salazar, Kimberly C

    2013-08-01

    Cephalosporins are one of the most commonly prescribed classes of antibiotics. Immediate IgE-mediated hypersensitivity reactions have been reported with use of a specific cephalosporin, as a cross-reaction between different cephalosporins or as a cross-reaction to other β-lactam antibiotics, namely, penicillin. Historically, frequent reports of anaphylaxis following administration of first- and second-generation cephalosporins to patients with a history of penicillin allergy led to the belief of a high degree of allergic cross-reactivity. More recent evidence reveals a significantly lower risk of cross-reactivity between penicillins and the newer-generation cephalosporins. The current thought is that a shared side chain, rather than the β-lactam ring structure, is the determining factor in immunologic cross-reactivity. Understanding the chemical structure of these agents has allowed us to identify the allergenic determinants for penicillin; however, the exact allergenic determinants of cephalosporins are less well understood. For this reason, standardized diagnostic skin testing is not available for cephalosporins as it is for penicillin. Nevertheless, skin testing to the cephalosporin in question, using a nonirritating concentration, provides additional information, which can further guide the work-up of a patient suspected of having an allergy to that drug. Together, the history and the skin test results can assist the allergist in the decision to recommend continued drug avoidance or to perform a graded challenge versus an induction of tolerance procedure.

  18. Immediate post-operative responses to transcatheter aortic valve implantation

    DEFF Research Database (Denmark)

    Egerod, Ingrid; Nielsen, Susanne; Lisby, Karen H.;

    2015-01-01

    Background:Conventional treatment for patients with severe symptomatic aortic stenosis is surgical aortic valve replacement (SAVR), but transcatheter aortic valve implantation (TAVI) has become a reliable alternative in high-risk patients.Aims:The aim of our study was to describe the post-operati......, predominantly continuous and at rest. We recommend the development of an evidence-based pathway to address the immediate post-operative issues in TAVI patients. Non-pharmacological interventions to prevent pain and promote sleep need to be explored.......-operative patient response to TAVI on the evening of the procedure and the following day before discharge from the coronary care unit. A secondary aim was to compare responses of patients younger and older than 80 years of age.Methods:A prospective, comparative observational study triangulating nurse assessment...... and structured interviews on a cohort of 54 Danish patients: 28/26 male/female, 26/28 younger/older than 80. Mean age in the younger/older group was 73/85 years.Results:After TAVI pain was experienced by 47 (87%) patients; 29 (62%) were restricted by pain, and 24 (44%) had discomfort at the femoral insertion...

  19. A Case of Immediate Hypersensitivity Reaction to Maltitol

    Directory of Open Access Journals (Sweden)

    Ana Rodríguez Trabado

    2017-01-01

    Full Text Available Background. Maltitol is a sugar alcohol that is frequently used as a noncaloric sweetener, although it is also used as an excipient, a plasticizer in gelatin capsules, and an emollient. It has not been previously described as an agent involved in immediate hypersensitivity reactions. Methods. We report on an anaphylactoid reaction with pharyngeal occlusion suffered by a 60-year-old man after ingestion of a candy containing maltitol syrup. A prick-to-prick test was performed with the candy and maltitol powder. Other allergens were excluded as causative agents of the adverse reaction, although the patient refused to undergo an oral challenge test with the candy. A basophil activation test (BAT was performed with maltitol powder, and a dose-response curve was generated. The test was also performed in 3 healthy controls. Results. Both prick-to-prick tests were negative. The result of the BAT was positive at all the concentrations tested in the patient’s blood and negative in all the controls. Conclusions. The BAT can help to clarify the agents implicated in an adverse reaction and can reduce the risk involved in diagnosis. The BAT can also prove useful in the study of reactions caused by low-molecular-weight antigens, for which routine diagnostic tests are not feasible.

  20. Chunk Limits and Length Limits in Immediate Recall: A Reconciliation

    Science.gov (United States)

    Chen, Zhijian; Cowan, Nelson

    2008-01-01

    Whereas some research on immediate recall of verbal lists has suggested that it is limited by the number of chunks that can be recalled (e.g., Tulving & Patkau, 1962; Cowan, Chen, & Rouder, 2004), other research has suggested that it is limited by the length of the material to be recalled (e.g., Baddeley, Thomson, & Buchanan, 1975). We investigated this question by teaching new paired associations between words to create two-word chunks. The results suggest that both chunk capacity limits and length limits come into play. For the free recall of 12-word lists, 6 pre-learned pairs could be recalled about as well as 6 pre-exposed singletons, suggesting a chunk limit. However, for the serially-ordered recall of 8-word lists, 4 pre-learned pairs could be recalled about as well as 8 pre-exposed singletons, suggesting a length limit. Other conditions yielded intermediate results suggesting that sometimes both limits may operate together. PMID:16393043

  1. Trends in Immediate Postmastectomy Breast Reconstruction in the United Kingdom

    Science.gov (United States)

    Bottle, Alex; Mayer, Erik; Patten, Darren K.; Rao, Christopher; Aylin, Paul; Hadjiminas, Dimitri J.; Athanasiou, Thanos; Darzi, Ara; Gui, Gerald

    2015-01-01

    Background: The study aimed to evaluate local and national trends in immediate breast reconstruction (IBR) using the national English administrative records, Hospital Episode Statistics. Our prediction was an increase in implant-only and free flap procedures and a decline in latissimus flap reconstructions. Methods: Data from an oncoplastic center were interrogated to derive numbers of implant-only, autologous latissimus dorsi (LD), LD-assisted, and autologous pedicled or free flap IBR procedures performed between 2004 and 2013. Similarly, Hospital Episode Statistics data were used to quantify national trends in these procedures from 1996 to 2012 using a curve fitting analysis. Results: National data suggest an increase in LD procedures between 1996 (n = 250) and 2002 (n = 958), a gradual rise until 2008 (n = 1398) followed by a decline until 2012 (n = 1090). As a percentage of total IBR, trends in LD flap reconstruction better fit a quadratic (R2 = 0.97) than a linear function (R2 = 0.63), confirming a proportional recent decline in LD flap procedures. Conversely, autologous (non-LD) flap reconstructions have increased (1996 = 0.44%; 2012 = 2.76%), whereas implant-only reconstructions have declined (1996 = 95.42%; 2012 = 84.92%). Locally, 70 implant-assisted LD procedures were performed in 2003 -2004, but only 2 were performed in 2012 to 2013. Conclusions: Implants are the most common IBR technique; autologous free flap procedures have increased, and pedicled LD flap procedures are in decline. PMID:26495220

  2. Eye movement evidence for an immediate Ganong effect.

    Science.gov (United States)

    Kingston, John; Levy, Joshua; Rysling, Amanda; Staub, Adrian

    2016-12-01

    Listeners tend to categorize an ambiguous speech sound so that it forms a word with its context (Ganong, 1980). This effect could reflect feedback from the lexicon to phonemic activation (McClelland & Elman, 1986), or the operation of a task-specific phonemic decision system (Norris, McQueen, & Cutler, 2000). Because the former account involves feedback between lexical and phonemic levels, it predicts that the lexicon's influence on phonemic decisions should be delayed and should gradually increase in strength. Previous response time experiments have not delivered a clear verdict as to whether this is the case, however. In 2 experiments, listeners' eye movements were tracked as they categorized phonemes using visually displayed response options. Lexically relevant information in the signal, the timing of which was confirmed by separate gating experiments, immediately increased eye movements toward the lexically supported response. This effect on eye movements then diminished over the course of the trial rather than continuing to increase. These results challenge the lexical feedback account. The present work also introduces a novel method for analyzing data from 'visual-world' type tasks, designed to assess when an experimental manipulation influences the probability of an eye movement toward the target. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  3. Autopsy-proven determinants of immediate fire death in lungs.

    Science.gov (United States)

    de Paiva, Luiz A S; Parra, Edwin R; da Rosa, Danieli C; Farhat, Cecília; Delmonte, Carlos; Capelozzi, Vera L

    2008-12-01

    In immediate fire deaths, pulmonary injury may be the main source of mortality, being important to document the histologic findings for the purpose of excluding other modes of death, such as from asphyxia with no gross findings. In this context, a group of morphologic determinants have been targeted with useful makers of pulmonary injury. To facilitate the determination of whether an individual was deceased before the start of a fire and validate the importance of parenchymal alterations in pulmonary injury in fire deaths, we studied lungs in victims of fire (N = 28) and suffocation (N = 40), creating a mathematical model using cluster analysis. For this purpose, a semiquantitative analysis of the distal parenchyma was performed to evaluate the amount of bronchiolar dilatation, overinsufflation (ductal and alveolar), collapse (ductal and alveolar), passive congestion, alveolar edema, and hemorrhage (interstitial and alveolar). These 7 histologic determinants were useful to discriminate fire (bronchiolar dilatation, ductal overinsuflation, alveolar overinsuflation, alveolar hemorrhage) from suffocation lung injuries (alveolar collapse, congestion, and edema). We conclude that these determinants should be included in the routine of forensic pathology.

  4. Evaluation of immediate soft tissue changes after rapid maxillary expansion

    Directory of Open Access Journals (Sweden)

    Ki Beom Kim

    2012-10-01

    Full Text Available OBJECTIVE: To evaluate immediate soft tissue changes following rapid maxillary expansion (RME in growing patients, using cone beam computed tomography (CBCT. METHODS: Twenty-three consecutive patients (10 male, 13 female treated by RME were selected. Patients were scanned using CBCT prior to placement of the rapid maxillary expander (T0, then immediately following full activation of the appliance (T1. Defined landmarks were then located on the pre- and post-treatment orientated images. Change in landmark position from pre- to post-treatment was then measured. In addition to landmarks, 10 direct measures were made to determine distance change without regard to direction to measure soft tissue change of the lips. RESULTS: Significant transverse expansion was measured on most soft tissue landmark locations. All the measures made showed significant change in the lip position with a lengthening of the vertical dimension of the upper lip, and a generalized decrease of anterior-posterior thickness of both the upper and lower lips. CONCLUSIONS: Significant changes in the soft tissue do occur with RME treatment. There is a transverse widening of the midface, and a thinning of the lips.OBJETIVO: avaliar as mudanças imediatas no tecido mole após a expansão rápida da maxila (ERM em pacientes em fase de crescimento, usando tomografia computadorizada de feixe cônico (TCFC. MÉTODOS: vinte e três pacientes (10 do sexo masculino e 13 do feminino tratados com ERM foram selecionados. Os pacientes foram escaneados por TCFC antes da implantação do expansor maxilar (T0 e imediatamente após a completa ativação do aparelho (T1. Pontos cefalométricos definidos foram localizados nas imagens pré- e pós-tratamento. As mudanças de posição desses pontos do pré- para o pós-tratamento foram, então, analisadas. Adicionalmente aos pontos, 10 medições diretas foram realizadas para determinar a mudança nas distâncias - independentemente da direção - nos

  5. Hydrologic conditions controlling runoff generation immediately after wildfire

    Science.gov (United States)

    Ebel, Brian A.; Moody, John A.; Martin, Deborah A.

    2012-01-01

    We investigated the control of postwildfire runoff by physical and hydraulic properties of soil, hydrologic states, and an ash layer immediately following wildfire. The field site is within the area burned by the 2010 Fourmile Canyon Fire in Colorado, USA. Physical and hydraulic property characterization included ash thickness, particle size distribution, hydraulic conductivity, and soil water retention curves. Soil water content and matric potential were measured indirectly at several depths below the soil surface to document hydrologic states underneath the ash layer in the unsaturated zone, whereas precipitation and surface runoff were measured directly. Measurements of soil water content showed that almost no water infiltrated below the ash layer into the near-surface soil in the burned site at the storm time scale (i.e., minutes to hours). Runoff generation processes were controlled by and highly sensitive to ash thickness and ash hydraulic properties. The ash layer stored from 97% to 99% of rainfall, which was critical for reducing runoff amounts. The hydrologic response to two rain storms with different rainfall amounts, rainfall intensity, and durations, only ten days apart, indicated that runoff generation was predominantly by the saturation-excess mechanism perched at the ash-soil interface during the first storm and predominantly by the infiltration-excess mechanism at the ash surface during the second storm. Contributing area was not static for the two storms and was 4% (saturation excess) to 68% (infiltration excess) of the catchment area. Our results showed the importance of including hydrologic conditions and hydraulic properties of the ash layer in postwildfire runoff generation models.

  6. Biowaiver monographs for immediate release solid oral dosage forms: piroxicam.

    Science.gov (United States)

    Shohin, Igor E; Kulinich, Julia I; Ramenskaya, Galina V; Abrahamsson, Bertil; Kopp, Sabine; Langguth, Peter; Polli, James E; Shah, Vinod P; Groot, D W; Barends, Dirk M; Dressman, Jennifer B

    2014-02-01

    Literature and experimental data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing piroxicam in the free acid form are reviewed. Piroxicam solubility and permeability, its therapeutic use and therapeutic index, pharmacokinetic properties, data related to the possibility of excipient interactions and reported BE/bioavailability (BA), and corresponding dissolution data are taken into consideration. The available data suggest that according to the current biopharmaceutics classification system (BCS) and all current guidances, piroxicam would be assigned to BCS Class II. The extent of piroxicam absorption seems not to depend on manufacturing conditions or excipients, so the risk of bioinequivalence in terms of area under the curve (AUC) is very low, but the rate of absorption (i.e., BE in terms of Cmax ) can be affected by the formulation. Current in vitro dissolution methods may not always reflect differences in terms of Cmax for BCS Class II weak acids; however, minor differences in absorption rate of piroxicam would not subject the patient to unacceptable risks: as piroxicam products may be taken before or after meals, the rate of absorption cannot be considered crucial to drug action. Therefore, a biowaiver for IR piroxicam solid oral dosage form is considered feasible, provided that (a) the test product contains only excipients, which are also present in IR solid oral drug products containing piroxicam, which have been approved in ICH or associated countries, for instance, those presented in Table 3 of this paper; (b) both the test and comparator drug products dissolve 85% in 30 min or less at pH 1.2, 4.5, and 6.8; and (c) the test product and comparator show dissolution profile similarity in pH 1.2, 4.5, and 6.8. When not all of these conditions can be fulfilled, BE of the products should be established in vivo.

  7. Immediate Direct-To-Implant Breast Reconstruction Using Anatomical Implants

    Directory of Open Access Journals (Sweden)

    Sung-Eun Kim

    2014-09-01

    Full Text Available BackgroundIn 2012, a new anatomic breast implant of form-stable silicone gel was introduced onto the Korean market. The intended use of this implant is in the area of aesthetic breast surgery, and many reports are promising. Thus far, however, there have been no reports on the use of this implant for breast reconstruction in Korea. We used this breast implant in breast reconstruction surgery and report our early experience.MethodsFrom November 2012 to April 2013, the Natrelle Style 410 form-stable anatomically shaped cohesive silicone gel-filled breast implant was used in 31 breasts of 30 patients for implant breast reconstruction with an acellular dermal matrix. Patients were treated with skin-sparing mastectomies followed by immediate breast reconstruction.ResultsThe mean breast resection volume was 240 mL (range, 83-540 mL. The mean size of the breast implants was 217 mL (range, 125-395 mL. Breast shape outcomes were considered acceptable. Infection and skin thinning occurred in one patient each, and hematoma and seroma did not occur. Three cases of wound dehiscence occurred, one requiring surgical intervention, while the others healed with conservative treatment in one month. Rippling did not occur. So far, complications such as capsular contracture and malrotation of breast implant have not yet arisen.ConclusionsBy using anatomic breast implants in breast reconstruction, we achieved satisfactory results with aesthetics better than those obtained with round breast implants. Therefore, we concluded that the anatomical implant is suitable for breast reconstruction.

  8. Does immediate dentin sealing influence the polymerization of impression materials?

    Science.gov (United States)

    Ghiggi, Paula Cristine; Steiger, Arno Kieling; Marcondes, Maurem Leitão; Mota, Eduardo Gonçalves; Burnett, Luiz Henrique; Spohr, Ana Maria

    2014-01-01

    Objectives: The objective of the following study is to evaluate the interaction between the resin materials used in immediate dentin sealing (IDS) techniques and impression materials with two different techniques to eliminate the oxygen-inhibition layer. Materials and Methods: The occlusal dentin surface of 35 human molars was exposed. The teeth were used in two Groups: Group 1 – Impression with Express XT; Group 2 – Impression with Impregum. Groups 1 and 2 were divided into 14 subgroups: Groups 1a and 2a – Control groups; 1b and 2b – IDS with Clearfil SE Bond (CSE); 1c and 2c – IDS with CSE + additional polymerization with glycerin jelly; 1d and 2d – IDS with CSE + alcohol; 1e and 2e – IDS with CSE and Protect Liner F (PLF); 1f and 2f – IDS with CSE and PLF + additional polymerization with glycerin jelly; and 1g and 2g – IDS with CSE and PLF + alcohol. Five teeth were used in each experimental group, and the tooth surface was photographed using a digital camera. Results: Small quantity of unpolymerized impression material remained attached to the CSE or to the PLF in Groups 1b and 1e. Groups 1c and 1d prevented the interaction. Small quantity of polymerized impression material remained attached to the CSE or to the PLF for Groups 2b and 2e. The same interaction was observed for Groups 2c and 2d. For Groups 2c and 2f, no interactions were observed. Conclusion: Resin materials interacted with impression materials. The application of glycerin jelly and alcohol prevented the interaction of CSE with Express XT and PLF with Impregum; however, these treatments were not completely effective in preventing the interaction of CSE with Impregum and PLF with Express XT. PMID:25202218

  9. Integrated testlets and the immediate feedback assessment technique

    Science.gov (United States)

    Slepkov, Aaron D.

    2013-10-01

    We describe how an answer-until-correct multiple-choice (MC) response format allows for the construction of fully multiple-choice examinations designed to operate much as a hybrid between standard MC and constructed-response (CR) testing. With this tool—the immediate feedback assessment technique (IF-AT)—students gain complete knowledge of the correct answer for each question during the examination and can use such information for solving subsequent test items. This feature allows for the creation of a new type of context-dependent item set: the "integrated testlet." In an integrated testlet, certain items are purposefully inter-dependent and are thus presented in a particular order. Such integrated testlets represent a proxy of typical CR questions, but with a straightforward and uniform marking scheme that also allows for granting partial credit for proximal knowledge. As proof-of-principle, we present a case study of an IF-AT-scored midterm and final examination for an introductory physics course and discuss specific testlets possessing varying degrees of integration. In total, the polychotomously scored items are found to allow for excellent discrimination, with a mean item-total correlation measure for the combined 45 items of the two examinations of r¯'=0.41±0.13 (mean ± standard deviation) and a final examination test reliability of α = 0.82 (n = 25 items). Furthermore, partial credit is shown to be allocated in a discriminating and valid manner in these examinations. As has been found in other disciplines, the reaction of undergraduate physics students to the IF-AT is highly positive, further motivating its expanded use in formal classroom assessments.

  10. Immediate Small Side Branch Occlusion after Percutaneous Coronary Intervention

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Ostovan

    2007-09-01

    Full Text Available Background: Small side branches, albeit less important than their larger counterparts, have not yet received due attention in the literature. Nor has there ever been a comparison between drug-eluting stents and bare metal stents apropos side branch occlusion. The aim of this study was to compare the patency of small (≥0.5 and ≤1.5 mm in diameter side branches with respect to bare metal vs. drug-eluting stents immediately after their deployment.Methods: This prospective bi-center study, conducted between June 2005 and January 2007, enrolled 82 patients treated with ≥1 of two stents (TAXUSTM LiberteTM or LiberteTM. Side branches ≥0.5 and <1.5 mm in diameter arising from the main vessel at the lesion site were evaluated. Results: Thirty-eight patients were treated with 42 LiberteTM stents (58 side branches and forty-four patients with 50 TAXUSTM LiberteTM (102 side branches. The rate of small side branch occlusion was 35.3% (36 in the TAXUSTM LiberteTM group compared to 29.31% (15 in the LiberteTM group (P-value= 0.7. The presence of type 1 side branch morphology (Lefevre classification was the most powerful predictor of small side branch occlusion (P-value=0.03. Conclusion: This study shows that drug-eluting stents are not inferior to bare metal stents as regards small side branch occlusion during coronary stenting

  11. The effects of immediate and delayed summarizing on judgments of learning, studying patterns and achievement

    OpenAIRE

    Ma, Wenting

    2008-01-01

    This study explored whether writing a summary immediately or with delay after studying can improve learners? metacomprehension accuracy, influence their regulation of study, and enhance reading comprehension immediately and under transfer conditions. Undergraduates (N=75) were randomly assigned to three groups: no summary, immediate summary and delayed summary. After screening data to remove participants who did not apply plausible effort, no statistically detectable differences were found fo...

  12. Involvement of Histamine and RhoA/ROCK in Penicillin Immediate Hypersensitivity Reactions

    OpenAIRE

    Jiayin Han; Yan Yi; Chunying Li; Yushi Zhang; Lianmei Wang; Yong Zhao; Chen Pan; Aihua Liang

    2016-01-01

    The mechanism of penicillin immediate hypersensitivity reactions has not been completely elucidated. These reactions are generally considered to be mediated by IgE, but penicillin-specific IgE could not be detected in most cases. This study demonstrated that penicillin was able to cause vascular hyperpermeability in a mouse model mimicking clinical symptoms of penicillin immediate hypersensitivity reactions. The first exposure to penicillin also induced immediate edema and exudative reactions...

  13. Delirium: a cause for concern beyond the immediate postoperative period.

    Science.gov (United States)

    Martin, Billie-Jean; Buth, Karen J; Arora, Rakesh C; Baskett, Roger J F

    2012-04-01

    Delirium is a common neurologic complication after cardiac surgery, and may be associated with increased morbidity and mortality. Research has focused on potential causes of delirium, with little attention to its sequelae. Perioperative data were collected prospectively on all isolated cases of coronary artery bypass grafting (CABG) performed from 1995 to 2006 at a single center. The definition of delirium used in the study was that of the Society of Thoracic Surgeons. Characteristics of patients who became delirious postoperatively were compared with those of patients who did not. The outcomes of interest were long-term all-cause mortality, hospital admission for stroke, and in-hospital mortality, examined in all three cases through multivariate analysis. Of 8,474 patients who underwent CABG within the defined period, 496 (5.8%) developed postoperative delirium and 229 (2.7%) died while in the hospital. At baseline, patients who developed delirium were more likely to be older and to have a greater burden of comorbid illness. Delirium was an independent predictor of perioperative stroke (odds ratio [OR]; 1.96; 95% confidence interval [CI], 1.22 to 3.16), but was not associated with in-hospital mortality (OR, 0.81; 95%CI, 0.49 to 1.34). Delirious patients had a median postoperative hospital stay of 12 days (interquartile range [IQR], 8 to 21 days) versus 6 days (IQR, 5 to 8 days) for those who were nondelirious. Delirium was identified as an independent predictor of all-cause mortality (hazard ratio [HR], 1.52; 95%CI, 1.29 to 1.78) and hospitalization for stroke (HR, 1.54; 95%CI, 1.10 to 2.17). There was an association between delirium and adverse outcomes after CABG that persisted beyond the immediate perioperative period. Patients with delirium after CABG appear to have an increased long-term risk of death and stroke. The advancing age and rising rates of delirium in the CABG population make it necessary to address the prevention and management of delirium in this

  14. CAUSE OF IMMEDIATE DEATH BY LARGE DOSES OF BOTULINUS TOXIN.

    Science.gov (United States)

    Bronfenbrenner, J J; Schlesinger, M J; Orr, P F

    1924-06-30

    Parenteral introduction of amounts of the culture filtrate of Bacillus botulinus greatly in excess of the minimum lethal dose has been observed to cause the practically immediate death of mice. This result is due to the presence in the filtrates of a chemical poison possessing properties distinct from those of the contained botulinus toxin which itself acts only after a well defined period of incubation. This chemical poison is not neutralized by botulinus antitoxin; it is effective only when large amounts of the culture filtrate are given; it is thermostable, not being destroyed when heated in the autoclave in a sealed tube, though when it is heated in an open container its toxicity diminishes with a coincidental volatilization of basic material. The volatile substance can be identified as ammonia. Death resulting from the injection of comparatively large amounts of ammonium salts (0.1 gm.) is easily distinguished from that due to botulism, both through the character of the symptoms and the absence of an incubation period. However, when the amount of toxic salts injected is smaller (0.01 gm.), the symptoms of poisoning are not so characteristic and death may be delayed long enough to suggest a period of incubation similar to that observed in botulism (Table IV). This circumstance is of importance in connection with the examination of partly decomposed food products in which the presence of botulinus toxin is suspected. As a rule such suspected material is injected in massive doses (0.5 to 1 cc.) in mice. It is conceivable that such spoiled foods may be contaminated with common putrefactive bacteria yielding ammonia during their growth and thus may cause death of the test animals. If in such tests mice passively protected by the preliminary injection of an excess of antitoxin be used in addition to normal animals, the chances of an error in the interpretation of the results will be materially reduced, though not ruled out. Unfortunately for such a procedure

  15. Cost-effectiveness of 'immediate IVF' versus 'delayed IVF': a prospective study

    NARCIS (Netherlands)

    Eijkemans, M.J.; Kersten, F.A.M.; Lintsen, A.M.E.; Hunault, C.C.; Bouwmans, C.A.; Roijen, L.H.; Habbema, J.D.; Braat, D.D.M.

    2017-01-01

    STUDY QUESTION: How does the cost-effectiveness (CE) of immediate IVF compared with postponing IVF for 1 year, depend on prognostic characteristics of the couple? SUMMARY ANSWER: The CE ratio, i.e. the incremental costs of immediate versus delayed IVF per extra live birth, is the highest (range of

  16. 19 CFR 143.36 - Form of immediate delivery, entry and entry summary.

    Science.gov (United States)

    2010-04-01

    ... Form of immediate delivery, entry and entry summary. (a) Electronic form of data. If Customs determines... 19 Customs Duties 2 2010-04-01 2010-04-01 false Form of immediate delivery, entry and entry summary. 143.36 Section 143.36 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF...

  17. Discrimination Acquisition in Children with Developmental Disabilities under Immediate and Delayed Reinforcement

    Science.gov (United States)

    Sy, Jolene R.; Vollmer, Timothy R.

    2012-01-01

    We evaluated the discrimination acquisition of individuals with developmental disabilities under immediate and delayed reinforcement. In Experiment 1, discrimination between two alternatives was examined when reinforcement was immediate or delayed by 20 s, 30 s, or 40 s. In Experiment 2, discrimination between 2 alternatives was compared across an…

  18. Organization of Experience among Family Members in the Immediate Present: A Gestalt/Systems Integration.

    Science.gov (United States)

    Kaplan, Marvin L.; Kaplan, Netta R.

    1982-01-01

    Outlines two formulations that generate conceptual perspectives of immediate phenomena: (1) the family system has a time-enduring stability; (2) the family system has an immediate and temporary organization. Integrates systems thinking and Gestalt Therapy while recognizing individual experience as embedded in a self-maintaining system of the…

  19. Immediate loading of subcrestally placed dental implants in anterior and premolar sites.

    Science.gov (United States)

    Henningsen, Anders; Smeets, Ralf; Köppen, Kai; Sehner, Susanne; Kornmann, Frank; Gröbe, Alexander; Heiland, Max; Gerlach, Till

    2017-08-23

    Immediate loading of dental implants has been evolving into an appropriate procedure for the treatment of partially edentulous jaws. The purpose of this study was to evaluate the clinical success and radiological outcome of immediately and delayed loaded dental implants in anterior and premolar sites. In this retrospective study, data of 163 individuals requiring tooth removal with subsequent implant placement in anterior and premolar sites were analyzed. Implants were immediately loaded by provisional acrylic resin bridges or loaded with delay. Implants were followed up annually for up to 9 years including intraoral radiographs. A total of 285 implants in 163 patients were placed. 218 implants were immediately loaded and 67 implants with delay. Fifteen implants failed during the follow-up period resulting in survival rates of 94.5% for immediate loading and 95.5% for delayed loading. After an initial decrease of 0.3 mm in the first 12 months the marginal bone level remained stable. No statistically significant differences were found in marginal bone loss between immediately and delayed loaded implants (P = 0.518, 95% CI). Within the limits of this study, immediate loading of immediately subcrestally placed dental implants in anterior and premolar sites is a reliable treatment option for dental rehabilitation. Copyright © 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.

  20. The role of immediate and final goals in action planning: An fMRI study

    NARCIS (Netherlands)

    Majdandzic, J.; Grol, M.J.; Schie, H.T. van; Verhagen, L.; Toni, I.; Bekkering, H.

    2007-01-01

    To interact effectively with our environment, we need to specify the intended outcomes (goals) of our actions. In this process, immediate goals and final goals can be regarded as different levels within a hierarchically organized system for action planning: immediate goals and movement details are

  1. 78 FR 23945 - Agency Information Collection Activities: Entry and Immediate Delivery Application and Simplified...

    Science.gov (United States)

    2013-04-23

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Entry and Immediate... Budget (OMB) for review and approval in accordance with the Paperwork Reduction Act: Entry and Immediate... additional 30 days for public comments. This process is conducted in accordance with 5 CFR 1320.10. DATES...

  2. 76 FR 82315 - Agency Information Collection Activities: Entry/Immediate Delivery Application and Simplified Entry

    Science.gov (United States)

    2011-12-30

    ... SECURITY U.S. Customs and Border Protection Agency Information Collection Activities: Entry/Immediate... Budget (OMB) for review and approval in accordance with the Paperwork Reduction Act: Entry/Immediate... process is conducted in accordance with 5 CFR 1320.10. DATES: Written comments should be received on or...

  3. 19 CFR 142.51 - Changing election of entry or immediate delivery.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Changing election of entry or immediate delivery... SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) ENTRY PROCESS Line Release § 142.51 Changing election of entry or immediate delivery. An applicant who has already received a C-4 Code and wishes to change the...

  4. 78 FR 68888 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing and Immediate...

    Science.gov (United States)

    2013-11-15

    ... COMMISSION Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing and Immediate... immediate effectiveness pursuant to Section 19(b)(3)(A)(iii) of the Act \\8\\ and Rule 19b- 4(f)(4)(ii) \\9... on the subject line if email is used. To help the Commission process and review your comments more...

  5. Immediate weight-bearing after osteosynthesis of proximal tibial fractures may be allowed

    DEFF Research Database (Denmark)

    Haak, Karl Tobias; Palm, Henrik; Holck, Kim;

    2012-01-01

    Immediate weight-bearing following osteosynthesis of proximal tibial fractures is traditionally not allowed due to fear of articular fracture collapse. Anatomically shaped locking plates with sub-articular screws could improve stability and allow greater loading forces. The purpose of this study...... was to investigate if immediate weight-bearing can be allowed following locking plate osteosynthesis of proximal tibial fractures....

  6. Immediate non-occlusal loading of single implants in the aesthetic zone : a randomized clinical trial

    NARCIS (Netherlands)

    den Hartog, Laurens; Raghoebar, Gerry M.; Stellingsma, Kees; Vissink, Arjan; Meijer, Henny J. A.

    2011-01-01

    P>Aim This study compared the outcome of immediate non-occlusal loading with conventional loading for single implants in the maxillary aesthetic zone. It was hypothesized that immediate non-occlusal loading is not inferior to conventional loading. Materials and Methods Sixty-two patients with a miss

  7. Comparison of apical leakage between immediate versus delayed post space preparation using two resin sealers

    Directory of Open Access Journals (Sweden)

    Priyanka Kaushal Kalra

    2009-01-01

    Full Text Available Post & Core Procedures have became an integral part of a dentist′s arsenal. This study was carried out in order to assess the microleakage when immediate and delayed post space preparations were done using resin sealers. Immediate post space preparations showed lesser apical leakage as opposed to delayed post space preparation.

  8. Response inhibition and immediate arousal in children with high-functioning autism

    NARCIS (Netherlands)

    Raymaekers, Ruth; van der Meere, Jaap; Roeyers, Herbert

    2006-01-01

    The current study compared high-functioning children with autism (HFA) and a peer control group on an immediate arousal task measuring response inhibition. In one condition go stimuli were presented whereas in another condition a tone preceded the go stimulus. The tone caused an immediate arousal ef

  9. The Effects of Test Trial and Processing Level on Immediate and Delayed Retention

    Science.gov (United States)

    Chang, Sau Hou

    2017-01-01

    The purpose of the present study was to investigate the effects of test trial and processing level on immediate and delayed retention. A 2 × 2 × 2 mixed ANOVAs was used with two between-subject factors of test trial (single test, repeated test) and processing level (shallow, deep), and one within-subject factor of final recall (immediate,…

  10. 19 CFR 147.14 - Articles not to be immediately entered and delivered to a fair.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Articles not to be immediately entered and delivered to a fair. 147.14 Section 147.14 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) TRADE FAIRS Procedure for Importation § 147.14 Articles not to be immediately entered...

  11. Success of immediate loading implants compared to conventionally-loaded implants: a literature review.

    Science.gov (United States)

    Al-Sawai, Abdul-Aziz; Labib, Hussein

    2016-08-01

    The purpose of this systematic literature review was to compare the clinical performance between conventionally- (delayed) and immediately-loaded implants. A literature search of studies published between 1995 and 2012 was performed using several electronic databases and the following key words: "immediate loading", "dental implants", "immediate function", "early loading", "oral implants", "immediate restoration", and "systematic review" was performed. The electronic search was supplemented with hand-searching in dental journals and cross-referencing within the selected articles. Studies were considered for inclusion if they analyzed the success of the immediate loading protocol for implants, with emphasis given to randomized, controlled clinical trials. Among the clinical studies extracted from the literature, 120 studies met the inclusion criteria and were included in this systematic review. These studies included trials that involved yielded consistent results of success rates of immediately-loaded implants comparable to those known from conventionally-loaded implants, which were subjected to the immediate loading protocol or other loading protocols. According to the findings, there is evidence to suggest that immediate loading protocols demonstrate high implant survival rates and could be cautiously recommended for certain clinical situations. However, studies with a high level of evidence, especially randomized, controlled trials, performed over a longer timeframe are required to show a clear benefit over conventional and other loading types.

  12. The clinical course of immediate breast implant reconstruction after breast cancer

    DEFF Research Database (Denmark)

    Hvilsom, Gitte B.; Friis, Søren; Frederiksen, Kirsten

    2011-01-01

    The number of women suitable for breast conserving treatment as well as immediate reconstruction after breast cancer has been increasing, and studies of complications hereafter are needed.......The number of women suitable for breast conserving treatment as well as immediate reconstruction after breast cancer has been increasing, and studies of complications hereafter are needed....

  13. Discrimination Acquisition in Children with Developmental Disabilities under Immediate and Delayed Reinforcement

    Science.gov (United States)

    Sy, Jolene R.; Vollmer, Timothy R.

    2012-01-01

    We evaluated the discrimination acquisition of individuals with developmental disabilities under immediate and delayed reinforcement. In Experiment 1, discrimination between two alternatives was examined when reinforcement was immediate or delayed by 20 s, 30 s, or 40 s. In Experiment 2, discrimination between 2 alternatives was compared across an…

  14. Opioid Treatment Patterns Following Prescription of Immediate-Release Hydrocodone.

    Science.gov (United States)

    Ben-Joseph, Rami; Bell, Jill A; Brixner, Diana; Kansal, Anuraag; Paramore, Clark; Chitnis, Abhishek; Holly, Pamela; S Burgoyne, Douglas

    2016-04-01

    Immediate-release (IR) hydrocodone is the most widely prescribed opioid in the United States; however, little is known about the utilization patterns and duration of opioid use among patients prescribed IR hydrocodone. A better understanding of the use of IR hydrocodone would result in more appropriate prescribing patterns of extended-release opioids. To assess downstream length of opioid therapy and utilization patterns of extended-release/long-acting (ER/LA) opioids among patients on IR hydrocodone to provide a better understanding of how IR and ER/LA opioids are used to manage pain. Retrospective analysis using health care claims from the Truven MarketScan Commercial, Medicare Supplemental, and Medicaid databases was performed. Patients prescribed IR hydrocodone during the 6-month baseline period (July 2011-December 2011) and with continuous enrollment for a 12-month follow-up period (2012) post-index date (January 1, 2012) were selected. Downstream length of therapy, defined as number of days supplied with opioids, and downstream use of ER/LA opioids during follow-up were examined by average pills per month (≤ 60 vs. > 60 pills per month) and days supply ( 60 pills per month than with ≤ 60 pills per month (7.8% vs. 1.2%, respectively, P 60 pills per month than with ≤ 60 pills per month. All results were consistent when examined by levels of days supply. A majority of the population prescribed IR hydrocodone was not prescribed opioid therapy beyond 2 months on average in the 1-year follow-up period. Only a small subset of patients with increased pills per month or days supply of IR hydrocodone in the baseline period continued to be high utilizers in the following year, averaging nearly 8 months of prescribed opioid use. A limited proportion of patients prescribed IR hydrocodone converted to ER/LA opioids. This knowledge can assist policymakers and physicians, providing an opportunity to identify small subsets of patients to improve ER/LA opioid prescribing

  15. Immediate implants in extraction sockets with periapical lesions: an illustrated review

    Directory of Open Access Journals (Sweden)

    Arthur B. Novaes Jr.

    2013-10-01

    Full Text Available Aim Immediate implantation has gained great attention since first proposed. Immediate implants in replacement of teeth with periapical lesion is, to date, an issue of discussion. The aim of this study is to perform an illustrated literature review of immediate implants in sockets exhibiting previous periapical lesions.Materials and methods A search on medline/EMBASE database was done for the literature review which is presented together with two case reports illustrating the state of the art of immediate implants on sockets with periapical lesions. Both cases are presented in areas with great aesthetic demands and a periapical lesion of considerable size. The two cases were conducted following strict granulation tissue removal and careful rinsing and pre-operative antibiotics, followed by good primary stability of the dental implant.Results and conclusion Both cases represented successes in aesthetics and function, describing a successful protocol for immediate implant installation in areas exhibiting periapical lesions.

  16. Intrapersonal Achievement Goals and Underlying Reasons among Long Distance Runners: Their Relation with Race Experience, Self-Talk, and Running Time

    Directory of Open Access Journals (Sweden)

    Jochen Delrue

    2016-07-01

    Full Text Available In a sample of long distance runners, we examined the role of type of intrapersonal achievement goals (i.e., approach versus avoidance and type of underlying reasons (i.e., autonomous and controlled, assessed prior to the race, as predictors of both pre-race (e.g., race appraisals and post-race (e.g., flow experience outcomes. Of 221 (62.4% males runners, 111 reported pursuing an intrapersonal-approach goal (i.e., doing better than before as their dominant or preferred achievement goal for the race, while 86 prioritized intrapersonal-avoidance goals (i.e., avoiding to perform worse than before. Regression and path analyses showed that the type of achievement goals predicted none of the outcomes except for running time, with approach goals predicting better performance when compared to avoidance goals. Path analyses revealed that autonomous reasons underlying intrapersonal goal pursuit related positively to pre-race challenge appraisals, performance and, via need satisfaction, to flow experience. Interestingly, controlled reasons positively related to pre-race threat appraisals and positively predicted both positive and negative self-talk, with both yielding opposing relations with flow. These findings complement past research on the intersection between the Achievement Goal Approach and Self-Determination Theory and highlight the value of studying the reasons underlying intrapersonal achievement goals.

  17. Minimal guided bone regeneration procedure for immediate implant placement in the esthetic zone

    Directory of Open Access Journals (Sweden)

    Nettemu Sunil Kumar

    2013-01-01

    Full Text Available The anterior maxilla presents a challenging milieu interior for ideal placement of implants because of the compromised bone quality. With the advent of intraoral bone harvesting and augmentation techniques, immediate implant placement into fresh extraction sockets have become more predictable. Immediate implant placement has numerous advantages compared to the delayed procedure including superior esthetic and functional outcomes, maintenance of soft and hard tissue integrity and increased patient compliance. This case report exhibits immediate implant placement in the maxillary esthetic zone by combining a minimal invasive autogenous block bone graft harvest technique for ensuring successful osseointegration of the implant at the extraction site.

  18. 13 Animal Emergencies That Should Receive Immediate Veterinary Consultation and/or Care

    Science.gov (United States)

    ... Public Health 13 Animal Emergencies that Require Immediate Veterinary Consultation and/or Care Severe bleeding or bleeding ... Map | Privacy | Terms of Use Copyright © 2017 American Veterinary Medical Association

  19. Immediate behavioural responses to earthquakes in Christchurch, New Zealand, and Hitachi, Japan.

    Science.gov (United States)

    Lindell, Michael K; Prater, Carla S; Wu, Hao Che; Huang, Shih-Kai; Johnston, David M; Becker, Julia S; Shiroshita, Hideyuki

    2016-01-01

    This study examines people's immediate responses to earthquakes in Christchurch, New Zealand, and Hitachi, Japan. Data collected from 257 respondents in Christchurch and 332 respondents in Hitachi revealed notable similarities between the two cities in people's emotional reactions, risk perceptions, and immediate protective actions during the events. Respondents' physical, household, and social contexts were quite similar, but Hitachi residents reported somewhat higher levels of emotional reaction and risk perception than did Christchurch residents. Contrary to the recommendations of emergency officials, the most frequent response of residents in both cities was to freeze. Christchurch residents were more likely than Hitachi residents to drop to the ground and take cover, whereas Hitachi residents were more likely than Christchurch residents to evacuate immediately the building in which they were situated. There were relatively small correlations between immediate behavioural responses and demographic characteristics, earthquake experience, and physical, social, or household context. © 2016 The Author(s). Disasters © Overseas Development Institute, 2016.

  20. An improved car-following model considering the immediately ahead car's velocity difference

    Science.gov (United States)

    Yu, Shaowei; Zhao, Xiangmo; Xu, Zhigang; Shi, Zhongke

    2016-11-01

    The field car-following data at a signalized intersection of Jinan in China are collected for data mining. An improved car-following model considering the immediately ahead car's velocity difference on a single-lane road was proposed, calibrated and verified based on full velocity difference model. The results of some numerical simulations indicate that the immediately ahead car's velocity difference has significant effects on the following car's motion, that the improved car-following model fits the measured data well and can qualitatively describe the impacts of the immediately ahead car's velocity difference on traffic flow, and that modeling the car-following behavior considering the immediately ahead car's velocity difference can improve the stability of the simulated traffic flow.

  1. Process Optimization of a Novel Immediate Release Film Coating System using QbD Principles

    National Research Council Canada - National Science Library

    Teckoe, Jason; Mascaro, Tracey; Farrell, Thomas P; Rajabi-Siahboomi, Ali R

    2013-01-01

    This work describes a quality-by-design (QbD) approach to determine the optimal coating process conditions and robust process operating space for an immediate release aqueous film coating system (Opadry® 200...

  2. Semantic interference in immediate and delayed naming and reading: Attention and task decisions

    NARCIS (Netherlands)

    Piai, V.; Roelofs, A.P.A.; Schriefers, H.J.

    2011-01-01

    Disagreement exists about whether lexical selection in word production is a competitive process. Competition predicts semantic interference from distractor words in immediate but not in delayed picture naming. In contrast, Janssen, Schirm, Mahon, and Caramazza (2008) obtained semantic interference

  3. Immediate skin and mucosal symptoms from pot plants and vegetables in gardeners and greenhouse workers

    DEFF Research Database (Denmark)

    Paulsen, E; Skov, Per Stahl; Andersen, Klaus Ejner

    1998-01-01

    cacti, Stephanotis floribunda, Euphorbia pulcherrima and Gerbera reactions. Other new species implicated in immediate-type reactions included Ficus pumila, Gardenia jasminoides, Hibiscus rosa-sinensis, Campanula, Columnea, Epipremnum aureum, Pelargonium and Primula vulgaris. Because of the high...

  4. Implant placement and immediate loading in aesthetic zone- A report of three cases

    Directory of Open Access Journals (Sweden)

    Vijay Deshmukh

    2009-01-01

    Full Text Available Single teeth replaced by implants in the aesthetic zone are one of the most challenging situations faced by a clinician. Recent studies have encouraged a progressive shortening of the healing period for single-tooth implants with immediate implantation and immediate loading being proposed for the aesthetic zone in the maxilla. The present report describes three cases with single tooth replacement in the anterior maxillary region by implant therapy with flapless technique followed by immediate provisionalization of the implant with all-ceramic crown. The patients exhibited no clinical or radiologic complications 1 year after loading. Implant placement and immediate loading of single tooth can provide an attractive treatment option in the aesthetic zone. Careful assessment must be made of mucosal and bone volumes in relation to implant placement for optimum aesthetic outcome.

  5. Impulsive people have a compulsion for immediate gratification - certain or uncertain.

    Directory of Open Access Journals (Sweden)

    Wojciech eBiałaszek

    2015-05-01

    Full Text Available Impulsivity has been defined as choosing the smaller more immediate reward over a larger more delayed reward. The purpose of this research was to gain a deeper understanding of the mental processes involved in the decision making. We examined participants’ rates of delay discounting and probability discounting to determine their correlation with time-probability trade-offs. To establish the time-probability trade-off rate, participants adjusted a risky, immediate payoff to a delayed, certain payoff. In effect, this yielded a probability equivalent of waiting time. We found a strong, positive correlation between delay discount rates and the time-probability trade-offs. This means that impulsive people have a compulsion for immediate gratification, independent of whether the immediate reward is certain or uncertain. Thus, they seem not to be concerned with risk but rather with time.

  6. Review of immediate-release omeprazole for the treatment of gastric acid-related disorders.

    Science.gov (United States)

    Castell, Donald

    2005-11-01

    Immediate-release omeprazole (Zegerid, Santarus) is the first immediate-release oral proton pump inhibitor to reach the market. As a powder formulation for oral suspension, it is indicated for the treatment of gastroesophageal reflux disease, erosive oesophagitis, duodenal ulcer and gastric ulcer, and is the only proton pump inhibitor approved for the reduction of risk of upper gastrointestinal bleeding in critically ill patients. Administration of immediate-release omeprazole at bedtime results in a rapid and sustained elevation of gastric pH, and seems to provide better night time control of gastric acidity than that observed with conventional morning dosing of delayed-release proton pump inhibitors. The immediate-release formulation may provide a good treatment option for patients who require flexible dosing, quick onset of action and nocturnal gastric acid control.

  7. Semantic interference in immediate and delayed naming and reading: Attention and task decisions

    NARCIS (Netherlands)

    Piai, V.; Roelofs, A.P.A.; Schriefers, H.J.

    2011-01-01

    Disagreement exists about whether lexical selection in word production is a competitive process. Competition predicts semantic interference from distractor words in immediate but not in delayed picture naming. In contrast, Janssen, Schirm, Mahon, and Caramazza (2008) obtained semantic interference i

  8. Continuation of cinacalcet immediately after renal transplantation: a prospective cohort study.

    NARCIS (Netherlands)

    Aalten, J.; Wetzels, J.F.M.; Hoitsma, A.J.

    2010-01-01

    BACKGROUND: cinacalcet is used for treating secondary hyperparathyroidism in dialysis patients, but it is currently unknown whether it can safely be continued immediately after renal transplantation. METHODS: we prospectively studied renal transplant recipients with secondary hyperparathyroidism who

  9. The Impact of the Immediate Feedback Assessment Technique on Course Evaluations

    National Research Council Canada - National Science Library

    Trent W. Maurer; Jerri J. Knopp

    2015-01-01

    ...) with the Immediate Feedback Assessment Technique (IF-AT) forms on summative course assessments. This project also quantifies grade inflation from utilizing different PCIR schemes and documents the percentage of possible partial credit students learned...

  10. The Impact of the Immediate Feedback Assessment Technique on Course Evaluations

    National Research Council Canada - National Science Library

    Maurer, Trent W; Kropp, Jerri J

    2015-01-01

    ...) with the Immediate Feedback Assessment Technique (IF-AT) forms on summative course assessments. This project also quantifies grade inflation from utilizing different PCIR schemes and documents the percentage of possible partial credit students earned...

  11. Immediate repair bond strengths of microhybrid, nanohybrid and nanofilled composites after different surface treatments

    NARCIS (Netherlands)

    Rinastiti, Margareta; Siswomihardjo, Widowati; Busscher, Henk J.; Ozcan, Mutlu

    2010-01-01

    Objectives: To evaluate immediate repair bond strengths and failure types of resin composites with and without surface conditioning and characterize the interacting composite surfaces by their surface composition and roughness. Methods: Microhybrid, nanohybrid and nanofilled resin composites were ph

  12. Immediate natural tooth pontic: A viable yet temporary prosthetic solution: A patient reported outcome

    Directory of Open Access Journals (Sweden)

    Sudhir Bhandari

    2012-01-01

    Conclusion: The concept of immediate pontic placement is surely a viable treatment option and promises an excellent transient esthetic solution for a lost tooth as well as enables good preparation of the extraction site for future prosthetic replacement.

  13. Soft Tissue Augmentation Techniques in Implants Placed and Provisionalized Immediately: A Systematic Review

    National Research Council Canada - National Science Library

    Rojo, Rosa; Prados-Frutos, Juan Carlos; Manchón, Ángel; Rodríguez-Molinero, Jesús; Sammartino, Gilberto; Calvo Guirado, José Luis; Gómez-de Diego, Rafael

    2016-01-01

      The aim of this study was to evaluate the effectiveness of techniques for soft tissue augmentation in the placement of immediate implants with and without provisionalization and to assess the quality...

  14. Impulsive people have a compulsion for immediate gratification—certain or uncertain

    Science.gov (United States)

    Białaszek, Wojciech; Gaik, Maciej; McGoun, Elton; Zielonka, Piotr

    2015-01-01

    Impulsivity has been defined as choosing the smaller more immediate reward over a larger more delayed reward. The purpose of this research was to gain a deeper understanding of the mental processes involved in the decision making. We examined participants’ rates of delay discounting and probability discounting to determine their correlation with time-probability trade-offs. To establish the time-probability trade-off rate, participants adjusted a risky, immediate payoff to a delayed, certain payoff. In effect, this yielded a probability equivalent of waiting time. We found a strong, positive correlation between delay discount rates and the time-probability trade-offs. This means that impulsive people have a compulsion for immediate gratification, independent of whether the immediate reward is certain or uncertain. Thus, they seem not to be concerned with risk but rather with time. PMID:25999872

  15. Accuracy Assessment of Immediate and Delayed Implant Placements Using CAD/CAM Surgical Guides.

    Science.gov (United States)

    Alzoubi, Fawaz; Massoomi, Nima; Nattestad, Anders

    2016-10-01

    The aim of this study is to assess the accuracy of immediately placed implants using Anatomage Invivo5 computer-assisted design/computer-assisted manufacturing (CAD/CAM) surgical guides and compare the accuracy to delayed implant placement protocol. Patients who had implants placed using Anatomage Invivo5 CAD/CAM surgical guides during the period of 2012-2015 were evaluated retrospectively. Patients who received immediate implant placements and/or delayed implant placements replacing 1-2 teeth were included in this study. Pre- and postsurgical images were superimposed to evaluate deviations at the crest, apex, and angle. A total of 40 implants placed in 29 patients were included in this study. The overall mean deviations measured at the crest, apex, and angle were 0.86 mm, 1.25 mm, and 3.79°, respectively. The means for the immediate group deviations were: crest = 0.85 mm, apex = 1.10, and angle = 3.49°. The means for the delayed group deviations were: crest = 0.88 mm, apex = 1.59, and angle = 4.29°. No statistically significant difference was found at the crest and angle; however, there was a statistically significant difference between the immediate and delayed group at the apex, with the immediate group presenting more accurate placements at the apical point than the delayed group. CAD/CAM surgical guides can be reliable tools to accurately place implants immediately and/or in a delayed fashion. No statistically significant differences were found between the delayed and the immediate group at the crest and angle, however apical position was more accurate in the immediate group.

  16. Immediate versus delayed postpartum use of levonorgestrel contraceptive implants: a randomized controlled trial in Uganda.

    Science.gov (United States)

    Averbach, Sarah; Kakaire, Othman; Kayiga, Herbert; Lester, Felicia; Sokoloff, Abby; Byamugisha, Josaphat; Dehlendorf, Christine; Steinauer, Jody

    2017-06-10

    Use of long-acting, highly effective contraception has the potential to improve women's ability to avoid short interpregnancy intervals, which are associated with an increased risk of maternal morbidity and mortality, and preterm delivery. In Uganda, contraceptive implants are not routinely available during the immediate postpartum period. The purpose of this study was to compare the proportion of women using levonorgestrel contraceptive implants at 6 months after delivery in women randomized to immediate or delayed insertion. This was a randomized controlled trial among women in Kampala, Uganda. Women who desired contraceptive implants were randomly assigned to insertion of a 2-rod contraceptive implant system containing 75 mg of levonorgestrel immediately following delivery (within 5 days of delivery and before discharge from the hospital) or delayed insertion (6 weeks postpartum). The primary outcome was implant utilization at 6 months postpartum. From June to October 2015, 205 women were randomized, 103 to the immediate group and 102 to the delayed group. Ninety-three percent completed the 6 month follow-up visit. At 6 months, implant use was higher in the immediate group compared with the delayed group (97% vs 68%; P < .001), as was the use of any highly effective contraceptive (98% vs 81%; P = .001). Women in the immediate group were more satisfied with the timing of implant placement. If given the choice, 81% of women in the immediate group and 63% of women in the delayed group would choose the same timing of placement again (P = .01). There were no serious adverse events in either group. Offering women the option of initiating contraceptive implants in the immediate postpartum period has the potential to increase contraceptive utilization, decrease unwanted pregnancies, prevent short interpregnancy intervals, and help women achieve their reproductive goals. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. Massive pulmonary embolism immediately diagnosed by transthoracic echocardiography and treated with tenecteplase fibrinolysis.

    Science.gov (United States)

    Brunetti, Natale Daniele; Ieva, Riccardo; Correale, Michele; De Gennaro, Luisa; Pellegrino, Pier Luigi; Dioguardi, Ezio; Bux, Francesca; Di Biase, Matteo

    2009-08-01

    We report the case of a 75-year-old woman with new onset dyspnoea, hypotension, and right bundle branch block. Transthoracic echocardiography (TTE) showed a thrombus in the right pulmonary artery and acute pulmonary embolism was diagnosed. The patient immediately underwent fibrinolysis with tenecteplase, with prompt recovery of clinical conditions and ECG anomalies. Bedside TTE might be helpful for immediate diagnosis of massive PE needing rapid treatment by fibrinolysis.

  18. Neurogenic Shock Immediately following Posterior Lumbar Interbody Fusion: Report of Two Cases

    OpenAIRE

    Matsumoto, Tomiya; Okuda, Shinya; Haku, Takamitsu; Maeda, Kazuya; Maeno, Takafumi; Yamashita, Tomoya; Yamasaki, Ryoji; Kuratsu, Shigeyuki; Iwasaki, Motoki

    2014-01-01

    Study Design Case report. Objective To present two cases of neurogenic shock that occurred immediately following posterior lumbar interbody fusion (PLIF) and that appeared to have been caused by the vasovagal reflex after dural injury and incarceration of the cauda equina. Case Report We present two cases of neurogenic shock that occurred immediately following PLIF. One patient had bradycardia, and the other developed cardiac arrest just after closing the surgical incision and opening the dra...

  19. Shallow discounting of delayed cocaine by male rhesus monkeys when immediate food is the choice alternative.

    Science.gov (United States)

    Huskinson, Sally L; Myerson, Joel; Green, Leonard; Rowlett, James K; Woolverton, William L; Freeman, Kevin B

    2016-12-01

    Huskinson et al. (2015) recently examined delay discounting in monkeys choosing between an immediate drug (cocaine) reinforcer and a delayed nondrug (food) reinforcer. The present experiment examined the reverse situation: choice between immediate nondrug (food) and delayed drug (cocaine) reinforcers. Whereas the former choice situation exemplifies drug abuse from a delay-discounting perspective, our interest in the latter choice situation is derived from the observation that drug abusers, who characteristically are associated with impulsive choice, typically must devote considerable time to procuring drugs, often at the expense of immediate nondrug alternatives. Accordingly, we analyzed 3 male rhesus monkeys' choices between immediate food and delayed cocaine (0.1 and 0.2 mg/kg/injection) using a hyperbolic model that allowed us to compare discounting rates between qualitatively different reinforcers. Choice of immediate food increased with food amount, and choice functions generally shifted leftward as delay to cocaine increased, indicating a decrease in the subjective value of cocaine. Compared with our previous delay-discounting experiment with immediate cocaine versus delayed food, both doses of delayed cocaine were discounted at a shallow rate. The present results demonstrate that rhesus monkeys will tolerate relatively long delays in an immediate-food versus delayed-drug situation, suggesting that in intertemporal choices between cocaine and food, the subjective value of cocaine is less affected by the delay until reinforcement than is the subjective value of delayed food. More generally, the present findings suggest that although drug abusers may choose impulsively when immediate drug reinforcement is available, they exercise self-control in the acquisition of a highly preferred, delayed drug reinforcer. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  20. The immediate versus delayed effects of an advertising literacy training on children's responses to product placement

    OpenAIRE

    De Jans, Steffi; Hudders, Liselot; Cauberghe, Veroline

    2016-01-01

    This experimental study investigated the immediate vs. delayed effects of an advertising literacy training on product placement effects for 7-8 versus 10-11 year old children. The advertising literacy training increased children’s understanding of product placement (advertising literacy), both for the younger and the older children and both immediately and in the longer run (measured after one week). In addition, this advertising literacy had a negative impact on pester power, but only when c...

  1. Survival of immediately versus delayed loaded short implants: a prospective case series study

    OpenAIRE

    Alvira González, Joaquín; Díaz Campos, Erick; Sánchez Garcés, María Angeles; Gay Escoda, Cosme

    2015-01-01

    Background To assess and compare survival rates of immediately and delayed loaded short implants (7 mm) in free ends of a partially edentulous jaw with moderate-severe alveolar bone resorption. Material and Methods 24 patients with atrophic edentulous free-ends were included in this prospective study. Four study groups were monitored monthly and their behavior was evaluated: bridges supported only by short implants and mixed short and long implant bridge groups, both with immediate and delaye...

  2. The role of computed tomography in the immediate workup of open globe injury.

    Science.gov (United States)

    Allon, Gilad; Beiran, Itzhak; Seider, Nir; Blumenthal, Eytan Z

    2016-08-04

    Immediate primary closure is indicated in cases of traumatic open globe injury. Orbital computed tomography (CT) is performed prior to primary closure in order to rule out possible intraocular foreign bodies (IOFB) and/or damage to adjacent extraocular as well as intraocular structures. The aim of the present study is to evaluate the yield of orbital CT scan in immediate clinical decision-making in cases of open globe injury. All cases of open globe injury treated in our institute during a 10-year period were reviewed. All underwent a CT scan before any surgical intervention, regardless of trauma severity. The influence of the CT scan results on decisions regarding the immediate treatment of the open globe injury was analyzed. A total of 125 cases of open globe injury were included in the present study. In none of these cases did the CT scan results have any influence on immediate treatment. The CT scan results did influence decisions that were made after the immediate operative stage. Computed tomography scan has limited value in immediate clinical decision-making in cases of open globe injury scheduled for primary closure. While not crucial prior to the initial procedure, it is of value in managing the case during the following few days as well as later on. This study suggests that a CT scan performed after the initial globe exploration and suturing procedure is a valid alternative to stalling the definite globe suturing process until a CT scan is obtained and interpreted.

  3. Clinical Effectiveness of Dry Needling Immediately After Application on Myofascial Trigger Point in Upper Trapezius Muscle.

    Science.gov (United States)

    Ziaeifar, Maryam; Arab, Amir Massoud; Nourbakhsh, Mohammad Reza

    2016-12-01

    The purpose of this study was to investigate the effect of dry needling (DN) on pain intensity and pressure pain threshold (PPT) compared with ischemic compression (IC) immediately and 48 hours after each treatment session in individuals with myofascial trigger points in the upper trapezius muscle. Thirty-one patients with myofascial trigger points in the upper trapezius muscle participated in this study. Patients were randomly assigned to a standard (N = 17) or experimental group (N = 14). The treatment protocol for the standard group consisted of IC, whereas the patients in the experimental group received DN. The results indicated that the effect size of the DN methods for pain intensity and PPT was considerably greater after 2 days compared with immediately after the treatment session. In contrast, the effect of the IC for PPT was greater immediately after treatment compared with the measures after 2 days. There was also no noticeable difference in the effect size for IC on pain intensity between the scores obtained immediately and 2 days after treatment. However, our data also revealed a greater effect size for DN on PPT after 2 days compared with the IC technique. In this study, DN improved the pain intensity and PPT after 2 days. However, it had no clinical improvement immediately after application because of muscle soreness. Thus, assessment of the effect of DN immediately after application can be criticized, and the results should be interpreted with caution.

  4. Chunk formation in immediate memory and how it relates to data compression.

    Science.gov (United States)

    Chekaf, Mustapha; Cowan, Nelson; Mathy, Fabien

    2016-10-01

    This paper attempts to evaluate the capacity of immediate memory to cope with new situations in relation to the compressibility of information likely to allow the formation of chunks. We constructed a task in which untrained participants had to immediately recall sequences of stimuli with possible associations between them. Compressibility of information was used to measure the chunkability of each sequence on a single trial. Compressibility refers to the recoding of information in a more compact representation. Although compressibility has almost exclusively been used to study long-term memory, our theory suggests that a compression process relying on redundancies within the structure of the list materials can occur very rapidly in immediate memory. The results indicated a span of about three items when the list had no structure, but increased linearly as structure was added. The amount of information retained in immediate memory was maximal for the most compressible sequences, particularly when information was ordered in a way that facilitated the compression process. We discuss the role of immediate memory in the rapid formation of chunks made up of new associations that did not already exist in long-term memory, and we conclude that immediate memory is the starting place for the reorganization of information. Copyright © 2016 Elsevier B.V. All rights reserved.

  5. Immediate restoration of NobelActive implants placed into fresh extraction sites in the anterior maxilla.

    Science.gov (United States)

    Bell, Christopher; Bell, Robert E

    2014-08-01

    The aim of this study is to compare the success rates of immediately placed and loaded NobelActive implants with the success rate of immediately placed implants that were allowed to osseointigrate prior to loading. The charts of all patients in a private oral surgery office receiving single-unit dental implants in the maxillary anterior region in fresh extraction sites from 2008-2011 were evaluated. All patients receiving NobelActive implants and immediate restorations were included in the study group, while those receiving implants with delayed restorations were included in the control group. Patient records were evaluated for variables such as age, gender, torque values at time of implant placement, smoking habits, use of bisphosphonates, and other significant diseases such as diabetes. The success rate of the study group was 92.9%, whereas the success rate of the control group was 97.6%. This was not statistically significant. Torque values of the failed implants of the study group were similar to those of successful implants in the study group. All implants placed in patients scheduled for immediate loading achieved high torque values and were able to be restored immediately. NobelActive implants were able to obtain high torque values for predictable immediate restoration in fresh extraction sites. Acceptable success rates with excellent soft tissue healing were achieved.

  6. 75 FR 37295 - Control of Immediate Precursor Used in the Illicit Manufacture of Fentanyl as a Schedule II...

    Science.gov (United States)

    2010-06-29

    ... 812(b). ANPP is the immediate chemical intermediary in the synthesis process currently used by... Enforcement Administration 21 CFR Part 1308 RIN 1117-AB16 Control of Immediate Precursor Used in the Illicit... the precursor chemical, 4-anilino-N-phenethyl-4-piperidine (ANPP) as an immediate precursor for the...

  7. 5 CFR 847.905 - How is the present value of an immediate annuity with credit for NAFI service computed?

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false How is the present value of an immediate....905 How is the present value of an immediate annuity with credit for NAFI service computed? (a) OPM will determine the present value of the immediate annuity including service credit for NAFI service...

  8. Review article: immediate-release proton-pump inhibitor therapy--potential advantages.

    Science.gov (United States)

    Howden, C W

    2005-12-01

    The absorption of most oral proton-pump inhibitors is delayed by the enteric coating required to protect the acid-labile proton-pump inhibitor from degradation in the stomach and, as a result, antisecretory effect is also delayed. This article provides an overview of the pharmacokinetics and pharmacodynamics of a new immediate-release omeprazole [(IR-OME) Zegerid power for oral suspension; Santarus Inc., San Diego, CA, USA] and its potential advantages over delayed-release proton-pump inhibitors. Immediate-release omeprazole has a higher mean peak plasma omeprazole concentration (C(max)) and a significantly shorter mean time to reach C(max) (t(max)) than delayed-release omeprazole. Immediate-release omeprazole 40 mg has a prolonged antisecretory effect with median intragastric pH above 4.0 for 18.6 h/day at steady-state, after 7 days of once daily dosing. The sodium bicarbonate in immediate-release omeprazole protects the uncoated omeprazole from degradation by gastric acid. The accelerated antisecretory action of immediate-release omeprazole compared with delayed-release omeprazole may be due to the activation of proton pumps by the rapid neutralization of intragastric acid by the sodium bicarbonate. The faster onset of action seen with immediate-release omeprazole is not achieved by using an antacid with a delayed-release proton-pump inhibitor, because administering antacids with conventional delayed-release proton-pump inhibitors does not significantly enhance absorption of the proton-pump inhibitor. In conclusion, immediate-release omeprazole is associated with rapid absorption of omeprazole and rapid onset of antisecretory effect, without compromising the duration of acid suppression.

  9. Immediate Restoration of Immediate Implants in the Esthetic Zone of the Maxilla Via the Copy-Abutment Technique: 5-Year Follow-Up of Pink Esthetic Scores.

    Science.gov (United States)

    Fürhauser, Rudolf; Mailath-Pokorny, Georg; Haas, Robert; Busenlechner, Dieter; Watzek, Georg; Pommer, Bernhard

    2017-02-01

    Implant esthetics may benefit from individualized zirconia abutments copying the emergence profile of the natural tooth and delivered within days after immediate implant insertion. To investigate the esthetic outcome of the Copy-Abutment technique using the Pink Esthetic Score (PES). A total of 77 patients with single-tooth implants in the anterior maxilla restored at the day of immediate implant placement using Copy-Abutments and provisional crowns were followed-up after 1 week, 1 month, 4 months, 6 months, 1, 2, 3, 4, and 5 years to assess implant esthetics. PES ranged between 7 and 14 (median: 13) and improved significantly between the 6 month and 1 year follow-up (p process deficiency deteriorated (p = .016). Mean mucosal recession was 0.26 ± 0.86 mm (range: 0-1.6) after 5 years and not related to gingival biotype. Copy-Abutments for immediate restoration of implants in the esthetic zone show satisfactory long-term esthetic outcomes. © 2016 Wiley Periodicals, Inc.

  10. Immediate postpartum levonorgestrel intrauterine device insertion and breast-feeding outcomes: a noninferiority randomized controlled trial.

    Science.gov (United States)

    Turok, David K; Leeman, Lawrence; Sanders, Jessica N; Thaxton, Lauren; Eggebroten, Jennifer L; Yonke, Nicole; Bullock, Holly; Singh, Rameet; Gawron, Lori M; Espey, Eve

    2017-08-23

    Immediate postpartum levonorgestrel intrauterine device insertion is increasing in frequency in the United States, but few studies have investigated the effect of early placement on breast-feeding outcomes. This study examined the effect of immediate vs delayed postpartum levonorgestrel intrauterine device insertion on breast-feeding outcomes. We conducted this noninferiority randomized controlled trial at the University of Utah and the University of New Mexico Health Sciences Centers from February 2014 through March 2016. Eligible women were pregnant and planned to breast-feed, spoke English or Spanish, were aged 18-40 years, and desired a levonorgestrel intrauterine device. Enrolled women were randomized 1:1 to immediate postpartum insertion or delayed insertion at 4-12 weeks' postpartum. Prespecified exclusion criteria included delivery <37.0 weeks' gestational age, chorioamnionitis, postpartum hemorrhage, contraindications to levonorgestrel intrauterine device insertion, and medical complications of pregnancy that could affect breast-feeding. We conducted per-protocol analysis as the primary approach, as it is considered the standard for noninferiority studies; we also report the alternative intent-to-treat analysis. We powered the study for the primary outcome, breast-feeding continuation at 8 weeks, to detect a 15% noninferiority margin between groups, requiring 132 participants in each arm. The secondary study outcome, time to lactogenesis, used a validated measure, and was analyzed by survival analysis and log rank test. We followed up participants for ongoing data collection for 6 months. Only the data analysis team was blinded to the intervention. We met the enrollment target with 319 participants, but lost 34 prior to randomization and excluded an additional 26 for medical complications prior to delivery. The final analytic sample included 132 in the immediate group and 127 in the delayed group. Report of any breast-feeding at 8 weeks in the immediate

  11. Vertical Root Fracture: Preservation of the Alveolar Ridge Using Immediate Implants

    Directory of Open Access Journals (Sweden)

    Edmar de Oliveira Oya

    2014-01-01

    Full Text Available Teeth with vertical root fracture (VRF have complete or incomplete fractures that begin in the root and extend toward the occlusal surface. The most frequent causes of VRF originate from physical trauma, occlusal prematurity, inadequate endodontic treatment, and iatrogenic causes. Diagnose is difficult and delay can cause stomatognathic system problem. The purpose of this case report was to evaluate immediate implant placement after extraction of teeth with vertical root fracture. For the 1st case, the VRF in 1st left lower molar was confirmed during surgical flap and at the same time, the tooth was removed and immediate implant was placed. For the 2nd case, the VRF 1st left lower molar was confirmed during endodontic access and at the same appointment, the tooth was removed and the immediate implant is placed. Several studies have shown that immediate implants have similar success rates when compared with late implants. Consider that this approach is a safe procedure with favorable prognosis. In cases of VRF, the main factor to be considered is the presence of adequate bone support and immediate implants can preserve the vertical bone height, adding the fact that good patient compliance reduces the number of surgical interventions and promotes the functionality of stomatognathic system.

  12. The Impact of Immediate and Delayed Corrective Feedback on Iranian EFL Learners’ Willingness to Communicate

    Directory of Open Access Journals (Sweden)

    Mahtab Zadkhast

    2017-09-01

    Full Text Available The present study investigated the impact of immediate and delayed corrective feedback on Iranian EFL learners’ willingness to communicate. To attain the purpose of the study, 45 females intermediate students that were roughly selected according to their previous grades and their assigned  level in language school were chosen to participate in this study. Then they were divided to three equal groups: Experimental group 1(immediate feedback, Experimental group 2 (delayed feedback and control group. In the first session, WTC questionnaire (MacIntyre ,2001 modified by Pourya Baghaei and Ali Dourakhshan was administered to all groups as pretests. In group 1 the students’ errors were corrected by the teacher immediately after committing but in the second group, the students’ errors were written by the teacher and her comments were given to them when they finished their tasks. For the control group, the routine procedure of New Headway intermediate was followed. After about 12 sessions WTC was repeated as posttests. The findings revealed that immediate and delayed corrective feedback have a significant effect on EFL students’ level of WTC. The results, also demonstrated that experimental group 1 (immediate feedback outweighed the other two groups in relation to their WTC. The findings have implication for pedagogy as well as further research.

  13. The role of immediate and final goals in action planning: an fMRI study.

    Science.gov (United States)

    Majdandzić, Jasminka; Grol, Meike J; van Schie, Hein T; Verhagen, Lennart; Toni, Ivan; Bekkering, Harold

    2007-08-15

    To interact effectively with our environment, we need to specify the intended outcomes (goals) of our actions. In this process, immediate goals and final goals can be regarded as different levels within a hierarchically organized system for action planning: immediate goals and movement details are selected to accomplish more remote goals. Behavioral studies support this notion of different levels of action planning, but the neurophysiological basis remains unclear. Using fMRI, we examined the neural correlates of preparing object manipulations based on either the desired end-state (the final goal) or the initial movement towards a target (the immediate goal). Subjects had to insert an object (consisting of a large and a small cube) into one of two corresponding large and small slots. The subjects were cued on either which slot to fill (Final Goal trials) or which object part to grasp (Immediate Goal trials). These actions required similar movements, but different planning. During Final Goal trials, there was differential preparatory activity along the superior frontal gyrus (bilaterally) and in left inferior parietal cortex. Immediate Goal trials evoked differential activity in occipito-parietal and occipito-temporal cortex. These findings support the notion that actions can be planned at different levels. We show that different fronto-parietal circuits plan the same action, by a relative emphasis on either selecting a sequence of movements to achieve a desired end-state, or selecting movements spatially compatible with given object properties.

  14. What can we learn about immediate memory from the development of children's free recall?

    Science.gov (United States)

    Jarrold, Christopher; Hall, Debbora; Harvey, Caroline E; Tam, Helen; Towse, John N; Zarandi, Amy L

    2015-01-01

    We ask the question: Which aspects of immediate memory performance improve with age? In two studies, we reexamine the widely held view that primary memory capacity estimates derived from children's immediate free recall are age invariant. This was done by assessing children's immediate free-recall accuracy while also measuring the order in which they elected to recall items (Experiment 1) and by encouraging children to begin free recall with items from towards the end of the presented list (Experiment 2). Across samples aged between 5 and 8 years we replicated the previously reported age-related changes in free-recall serial position functions when aggregated across all trials of the standard task, including an absence of age differences in the recency portion of this curve. However, we also show that this does not reflect the fact that primary memory capacity is constant across age. Instead, when we incorporate order of report information, clear age differences are evident in the recall of list-final items that are output at the start of a participant's response. In addition, the total amount that individuals recalled varied little across different types of free-recall tasks. These findings have clear implications for the use of immediate free recall as a means of providing potential indices of primary memory capacity and in the study of the development of immediate memory.

  15. The Effects of Test Trial and Processing Level on Immediate and Delayed Retention

    Science.gov (United States)

    Chang, Sau Hou

    2017-01-01

    The purpose of the present study was to investigate the effects of test trial and processing level on immediate and delayed retention. A 2 × 2 × 2 mixed ANOVAs was used with two between-subject factors of test trial (single test, repeated test) and processing level (shallow, deep), and one within-subject factor of final recall (immediate, delayed). Seventy-six college students were randomly assigned first to the single test (studied the stimulus words three times and took one free-recall test) and the repeated test trials (studied the stimulus words once and took three consecutive free-recall tests), and then to the shallow processing level (asked whether each stimulus word was presented in capital letter or in small letter) and the deep processing level (whether each stimulus word belonged to a particular category) to study forty stimulus words. The immediate test was administered five minutes after the trials, whereas the delayed test was administered one week later. Results showed that single test trial recalled more words than repeated test trial in immediate final free-recall test, participants in deep processing performed better than those in shallow processing in both immediate and delayed retention. However, the dominance of single test trial and deep processing did not happen in delayed retention. Additional study trials did not further enhance the delayed retention of words encoded in deep processing, but did enhance the delayed retention of words encoded in shallow processing. PMID:28344679

  16. Benefits of Immediate Extubation Following Free Tissue Transfer for Head and Neck Reconstruction.

    Science.gov (United States)

    Tamplen, Matthew L; Ricceri, Santo; Hemmat, Shirin; Seth, Rahul; Ryan, William R; Knott, P Daniel

    2016-09-01

    Background Immediate postprocedure extubation (cessation of mechanical ventilation) after free tissue transfer for head and neck reconstruction may improve outcomes, reduce intensive care unit and hospital length of stay, and reduce overall cost compared with delayed extubation in the intensive care unit. Methods Medical records of 180 consecutive patients undergoing free tissue transfer for head and neck reconstruction were reviewed. Patients immediately extubated in the operating room (immediate group, N = 63) were compared with patients who were extubated in the intensive care unit (delayed group, N = 117) by univariate and multivariate analysis. Results Medical complication rates and intensive care unit length of stay were significantly higher in the delayed extubation group (55.5 vs. 12.7%, p < 0.001, and 4.4 vs. 2.9 days, p < 0.001, respectively). Although the rate of preoperative alcohol use was similar between the two groups, significantly fewer patients underwent treatment for alcohol withdrawal or agitation in the immediate extubation group (3.2 vs. 27.4%, p = 0.001). There were no significant differences in surgical complication rates. Conclusion Immediate postprocedure extubation is associated with shorter intensive care unit length of stay, reduced medical complications, and reduced incidence of treatment for agitation/alcohol withdrawal for patients undergoing free tissue transfer for head and neck reconstruction.

  17. Rapid desensitization for non-immediate reactions in patients with cystic fibrosis.

    Science.gov (United States)

    Whitaker, P; Shaw, N; Gooi, J; Etherington, C; Conway, S; Peckham, D

    2011-07-01

    Non-immediate hypersensitivity reactions to antibiotics in patients with CF represent a real-life challenge for clinicians. Desensitization is often performed in patients who have exhausted all therapeutic options. Whilst desensitization is an established procedure for immediate reactions we assessed the outcomes and safety of desensitization for non-immediate reactions. We retrospectively reviewed 275 desensitization procedures in 42 patients with a range of non-immediate reactions to six commonly used antibiotics. Desensitization was performed using a 7-step rapid intravenous protocol on a normal medical ward. 250 (91%) of overall desensitization procedures were successful; however, this figure incorporates certain individuals having multiple successful procedures. Individual patient success ranged from 55% with tazocin through to 88% with tobramycin. In the 25 patients who failed desensitization the reactions were mild and the majority occurred within 48 h of starting treatment. Prophylactic anti-histamines and steroids did not reduce the risk of reaction. Whilst the mechanisms remain uncertain we can confirm that rapid desensitization is a safe and effective way of re-introducing an antibiotic to a patient with a non-immediate reaction. Copyright © 2011 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

  18. Involvement of Histamine and RhoA/ROCK in Penicillin Immediate Hypersensitivity Reactions.

    Science.gov (United States)

    Han, Jiayin; Yi, Yan; Li, Chunying; Zhang, Yushi; Wang, Lianmei; Zhao, Yong; Pan, Chen; Liang, Aihua

    2016-09-13

    The mechanism of penicillin immediate hypersensitivity reactions has not been completely elucidated. These reactions are generally considered to be mediated by IgE, but penicillin-specific IgE could not be detected in most cases. This study demonstrated that penicillin was able to cause vascular hyperpermeability in a mouse model mimicking clinical symptoms of penicillin immediate hypersensitivity reactions. The first exposure to penicillin also induced immediate edema and exudative reactions in ears and lungs of mice in a dose-dependent manner. Vasodilation was noted in microvessels in ears. These reactions were unlikely to be immune-mediated reactions, because no penicillin-specific IgE was produced. Furthermore, penicillin treatment directly elicited rapid histamine release. Penicillin also led to F-actin reorganization in human umbilical vein endothelial cells and increased the permeability of the endothelial monolayer. Activation of the RhoA/ROCK signaling pathway was observed in ears and lungs of mice and in endothelial cells after treatment with penicillin. Both an anti-histamine agent and a ROCK inhibitor attenuated penicillin immediate hypersensitivity reactions in mice. This study presents a novel mechanism of penicillin immediate hypersensitivity reactions and suggests a potential preventive approach against these reactions.

  19. Immediate versus delayed hysterectomy for endometrial carcinoma: surgical morbidity and hospital stay

    Energy Technology Data Exchange (ETDEWEB)

    Chambers, J.T.; Kapp, D.S.; Lawrence, R.; Kohorn, E.I.; Schwartz, P.E.

    1985-02-01

    A retrospective review presented is of the intraoperative complications, postoperative morbidity, and length of hospitalization in 138 patients with stage I endometrial carcinoma treated at Yale-New Haven Hospital from January 1, 1977 to December 31, 1981. One group (stage IA, grade 1) was treated with surgery alone; two groups were treated with preoperative intracavitary radium, followed with either an immediate or a delayed hysterectomy. The three groups were comparable in age, weight, and major preoperative medical problems. The mean estimated blood loss during surgery and transfusion requirements during hospitalization were similar for all three groups. The duration of the surgery in the immediate group was longer than the other two groups. The occurrence of febrile morbidity and major postoperative complications in the three groups was similar, except for bacteriuria, which was significantly more common in the immediate group. The length of the postoperative hospitalization was the same for each group; however, the delayed group as compared with the immediate group had a total hospitalization of two days longer. Hence, in the current study, immediate hysterectomy did not significantly increase the surgical or postoperative morbidity rate, compared with delayed hysterectomy. The single hospital stay in the former treatment group represented cost containment.

  20. The Effects of Test Trial and Processing Level on Immediate and Delayed Retention

    Directory of Open Access Journals (Sweden)

    Sau Hou Chang

    2017-03-01

    Full Text Available The purpose of the present study was to investigate the effects of test trial and processing level on immediate and delayed retention. A 2 × 2 × 2 mixed ANOVAs was used with two between-subject factors of test trial (single test, repeated test and processing level (shallow, deep, and one within-subject factor of final recall (immediate, delayed. Seventy-six college students were randomly assigned first to the single test (studied the stimulus words three times and took one free-recall test and the repeated test trials (studied the stimulus words once and took three consecutive free-recall tests, and then to the shallow processing level (asked whether each stimulus word was presented in capital letter or in small letter and the deep processing level (whether each stimulus word belonged to a particular category to study forty stimulus words. The immediate test was administered five minutes after the trials, whereas the delayed test was administered one week later. Results showed that single test trial recalled more words than repeated test trial in immediate final free-recall test, participants in deep processing performed better than those in shallow processing in both immediate and delayed retention. However, the dominance of single test trial and deep processing did not happen in delayed retention. Additional study trials did not further enhance the delayed retention of words encoded in deep processing, but did enhance the delayed retention of words encoded in shallow processing.

  1. Parietal lobe critically supports successful paired immediate and single-item delayed memory for targets.

    Science.gov (United States)

    Krumm, Sabine; Kivisaari, Sasa L; Monsch, Andreas U; Reinhardt, Julia; Ulmer, Stephan; Stippich, Christoph; Kressig, Reto W; Taylor, Kirsten I

    2017-05-01

    The parietal lobe is important for successful recognition memory, but its role is not yet fully understood. We investigated the parietal lobes' contribution to immediate paired-associate memory and delayed item-recognition memory separately for hits (targets) and correct rejections (distractors). We compared the behavioral performance of 56 patients with known parietal and medial temporal lobe dysfunction (i.e. early Alzheimer's Disease) to 56 healthy control participants in an immediate paired and delayed single item object memory task. Additionally, we performed voxel-based morphometry analyses to investigate the functional-neuroanatomic relationships between performance and voxel-based estimates of atrophy in whole-brain analyses. Behaviorally, all participants performed better identifying targets than rejecting distractors. The voxel-based morphometry analyses associated atrophy in the right ventral parietal cortex with fewer correct responses to familiar items (i.e. hits) in the immediate and delayed conditions. Additionally, medial temporal lobe integrity correlated with better performance in rejecting distractors, but not in identifying targets, in the immediate paired-associate task. Our findings suggest that the parietal lobe critically supports successful immediate and delayed target recognition memory, and that the ventral aspect of the parietal cortex and the medial temporal lobe may have complementary preferences for identifying targets and rejecting distractors, respectively, during recognition memory. Copyright © 2017. Published by Elsevier Inc.

  2. High temporal discounters overvalue immediate rewards rather than undervalue future rewards: an event-related brain potential study.

    Science.gov (United States)

    Cherniawsky, Avital S; Holroyd, Clay B

    2013-03-01

    Impulsivity is characterized in part by heightened sensitivity to immediate relative to future rewards. Although previous research has suggested that "high discounters" in intertemporal choice tasks tend to prefer immediate over future rewards because they devalue the latter, it remains possible that they instead overvalue immediate rewards. To investigate this question, we recorded the reward positivity, a component of the event-related brain potential (ERP) associated with reward processing, with participants engaged in a task in which they received both immediate and future rewards and nonrewards. The participants also completed a temporal discounting task without ERP recording. We found that immediate but not future rewards elicited the reward positivity. High discounters also produced larger reward positivities to immediate rewards than did low discounters, indicating that high discounters relatively overvalued immediate rewards. These findings suggest that high discounters may be more motivated than low discounters to work for monetary rewards, irrespective of the time of arrival of the incentives.

  3. Atraumatic extraction and immediate implant installation: The importance of maintaining the contour gingival tissues

    Science.gov (United States)

    Tavarez, Rudys Rodolfo De Jesus; dos Reis, Washigton Luís Machado; Rocha, Adrycila Teixeira; Firoozmand, Leily Macedo; Bandéca, Matheus Coêlho; Tonetto, Mateus Rodrigues; Malheiros, Adriana Santos

    2013-01-01

    There is an accelerated resorption in the first six months after the extraction of the dental element, both horizontally and vertically. These clinical changes normally undertake the aesthetic result of prosthetic rehabilitation, and implant installation after the extraction can be a resource to decrease resorption. The clinical case described in this paper demonstrates a sequence of clinical atraumatic extraction, and then the Immediate installation provisionalization. It is concluded that when carefully indicated and planned, this technique can provide an immediate result promising with maintaining the tooth gingival contour. How to cite this article: Tavarez RR, Machado dos Reis WL, Rocha AT, Firoozmand LM, Bandéca MC, Tonetto MR, Malheiros AS. Atraumatic extraction and immediate implant installation: The importance of maintaining the contour gingival tissues. J Int Oral Health 2013; 5(6):113-8 . PMID:24453455

  4. Immediate Antiretroviral Therapy Reduces Risk of Infection-Related Cancer During Early HIV Infection

    DEFF Research Database (Denmark)

    Borges, Álvaro H; Neuhaus, Jacqueline; Babiker, Abdel G;

    2016-01-01

    BACKGROUND:  In the Strategic Timing of Antiretroviral Treatment (START) study, immediate combination antiretroviral therapy (cART) initiation reduced cancer risk by 64%. We hypothesized that risk reduction was higher for infection-related cancer and determined by differences in CD4 cell counts...... and human immunodeficiency virus (HIV) RNA between the study arms. METHODS:  Incident malignancies in START were categorized into infection-related and infection-unrelated cancer. We used Cox models to assess factors associated with both cancer categories. We used sequential adjustment for baseline...... covariates, cancer risk factors, and HIV-specific variables to investigate potential mediators of cancer risk reduction with immediate cART. RESULTS:  There were 14 cancers among persons randomized to immediate cART (6 infection-related and 8 infection-unrelated) and 39 cancers in the deferred arm (23...

  5. Strategic extraction protocol: Use of an image-fusion stereolithographic guide for immediate implant placement.

    Science.gov (United States)

    Dada, Karim; Pariente, Leon; Daas, Marwan

    2016-11-01

    Increasingly, patients are demanding a smooth transition from a hopeless dentition to a fixed implant-supported prosthesis without the use of an interim removable denture. This raises new challenges in adapting computer-aided design and computer-aided manufacturing (CAD-CAM) techniques to patients whose treatment plan includes immediate implant placement in fresh extraction sockets. To facilitate this conversion to a rehabilitated dentition, a strategic extraction protocol (SEP) can be applied. The SEP consists of selecting strategic, remaining, hopeless teeth as abutments to stabilize an image-fusion stereolithographic guide and to allow the immediate placement of sufficient implants to support an immediately loaded fixed prosthesis. The remaining supporting teeth are extracted in the same surgical session before the placement of the interim prosthesis.

  6. Immediate loading of titanium hexed screw-type implants in the edentulous patient: case report.

    Science.gov (United States)

    Calvo, M P; Muller, E; Garg, A K

    2000-01-01

    Histologic and histomorphometric studies in both animals and humans have shown that more rapid and greater bone-to-implant contact can be achieved with implants that incorporate certain surface characteristics compared with the original machined-surface implants. Such findings are significant because various implant designs may allow the fixtures to sufficiently resist functional loading sooner than originally thought. The case report presented here indicates that immediate loading of hexed titanium screw-type implants in the anterior mandible can lead to successful osseointegration and clinical outcome. The number of implants placed, their distribution, and the type of rigid connection are critical considerations for immediate loading. A bone height that can accommodate dental implants > or = 10 mm long is recommended. Biomechanically, the implants to be immediately loaded must be stable and resistant to macromovement to ensure good osseointegration.

  7. The immediate effects of sigmoid colon manipulation on pressure pain thresholds in the lumbar spine.

    Science.gov (United States)

    McSweeney, Terence P; Thomson, Oliver P; Johnston, Ross

    2012-10-01

    Visceral manual therapy is increasingly used by UK osteopaths and manual therapists, but there is a paucity of research investigating its underlying mechanisms, and in particular in relation to hypoalgesia. The aim of this study was to investigate the immediate effects of osteopathic visceral mobilisation on pressure pain thresholds. A single-blinded, randomised, within subjects, repeated measures design was conducted on 15 asymptomatic subjects. Pressure pain thresholds were measured at the L1 paraspinal musculature and 1st dorsal interossei before and after osteopathic visceral mobilisation of the sigmoid colon. The results demonstrated a statistically significant improvement in pressure pain thresholds immediately after the intervention (P<0.001). This effect was not observed to be systemic, affecting only the L1 paraspinal musculature. This novel study provides new experimental evidence that visceral manual therapy can produce immediate hypoalgesia in somatic structures segmentally related to the organ being mobilised, in asymptomatic subjects.

  8. A new operative method for obtaining full-arch prostheses for immediate loading dental implants.

    Science.gov (United States)

    de Mello, Guilherme Paulo Scarpel; Mello, Elaine Duarte Artuso de; Corazza, Pedro Henrique

    2017-04-01

    Implant supported full-arch immediate prosthesis (also called the immediate Brånemark protocol) revolutionized dental clinical practice due to the aesthetic/functional benefits it offers to the patient. This work presents a simplified and efficient technique for implant supported full-arch immediate prosthesis fabrication. After diagnosing the necessity of the protocol, the implants were installed with a minimum torque of 35Ncm. For implant impression, the use of previously prepared castable cylinders (dispensing with impression posts), and a U-shaped acrylic (Mello technique) generated a cast without distortion. The Brånemark protocol was fabricated on this cast without the metal test specimen. The simplified technique proposed in this article for Brånemark protocol fabrication seemed to be effective. Copyright © 2016 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved.

  9. Gastric and masticatory performances in full-arch immediate loading rehabilitated patients.

    Science.gov (United States)

    Pesce, P; Menini, M; Furnari, M; Pera, F; Tealdo, T; Pera, P

    2015-09-01

    Full-arch immediate loading implant rehabilitations provide patients with compromised dentition an effective treatment to improve their aesthetic and function. Aim of this prospective cohort study was to investigate the correlation between masticatory ability and gastric emptying rates among these patients. Ten subjects (five men and five women) with compromised dentition were tested in two occasions: before treatment and 30 days after the immediate loading rehabilitation. Masticatory ability was evaluated using the sieves test, and the gastric half emptying time (T(1/2)) was assessed by means of the 13C-octanoic acid breath test. A statistically significant increment (P rehabilitated with full-arch immediate implant prostheses present a significant improvement of the gastric process.

  10. [Clinical stability of immediate load of domestic micro-titanium screws for anchorage in orthodontics].

    Science.gov (United States)

    Zheng, Qing-zhong; Xie, Xing-qian; Xie, Xue-mei; Wang, Jian; Yu, Xiao-jia

    2009-10-01

    To investigate the immediate load stability of domestic micro-titanium screws for anchorage in orthodontics. Adult orthodontic patients needing the greatest anchorage were included in the study. Domestic micro-titanium screws were used to be orthodontic anchorage, immediate implantation and loading were conducted. A total of 52 implants of domestic micro-titanium anchorage in 20 patients were used. Forty-seven implants were successful in 20 patients,5 failed. The total loading time was 3-8 months. Domestic micro-titanium implant screws for anchorage can meet the needs of clinical orthodontics. However, immediate loading results in 10.4% failure rate, especially for the implant with a diameter of 1.2mmx7mm. Supported by Science and Technology Development Foundation of Fengxian District, Shanghai Municipality (Grant No. 090602).

  11. Sex differences in smoking cue reactivity: craving, negative affect, and preference for immediate smoking.

    Science.gov (United States)

    Doran, Neal

    2014-01-01

    Female smokers have greater difficulty quitting, possibly due to increased reactivity to smoking-related cues. This study assessed sex differences in craving, affect, and preference for immediate smoking after cue exposure. Regular smokers (n = 60; 50% female) were exposed to smoking and neutral cues in separate, counterbalanced sessions. Outcomes included changes in craving and affect and preference for immediate smoking following cue exposure. Findings indicated that women exhibited greater preference for immediate smoking (p = .004), and reported greater cue-induced increases in cigarette craving (p = .046) and negative affect (p = .025). These data suggest that women may have greater difficulty inhibiting smoking after cue exposure, possibly as a consequence of greater increases in craving and negative affect. Findings suggest a mechanism that may contribute to greater cessation failure among female smokers. © American Academy of Addiction Psychiatry.

  12. [Differences between immediate and 30-day deaths due to traffic injuries according to forensic sources].

    Science.gov (United States)

    Barbería, Eneko; Suelves, Josep M; Xifró, Alexandre; Medallo, Jordi

    2015-09-01

    To study immediate (same day of the collision) and delayed (within 30 days of the collision) deaths due to traffic injuries in Catalonia (Spain) according to forensic sources and to assess the differences between the two kinds of deaths. An observational study was conducted of all the traffic accident deaths registered in the Institute of Legal Medicine of Catalonia between January 1(st) 2005 and December 31(st) 2014. Data analysis was performed using the SPSS v.18.0 statistical package. Comparisons of proportions were based on the χ(2) test. During the study period, 4044 deaths due to traffic injuries were recorded. Deaths within 30 days included more women, minors, elderly people, and pedestrians than immediate deaths. Traffic injury deaths in the 30 days following a crash differ from immediate deaths. Copyright © 2014 SESPAS. Published by Elsevier Espana. All rights reserved.

  13. Overt vs. covert speed cameras in combination with delayed vs. immediate feedback to the offender.

    Science.gov (United States)

    Marciano, Hadas; Setter, Pe'erly; Norman, Joel

    2015-06-01

    Speeding is a major problem in road safety because it increases both the probability of accidents and the severity of injuries if an accident occurs. Speed cameras are one of the most common speed enforcement tools. Most of the speed cameras around the world are overt, but there is evidence that this can cause a "kangaroo effect" in driving patterns. One suggested alternative to prevent this kangaroo effect is the use of covert cameras. Another issue relevant to the effect of enforcement countermeasures on speeding is the timing of the fine. There is general agreement on the importance of the immediacy of the punishment, however, in the context of speed limit enforcement, implementing such immediate punishment is difficult. An immediate feedback that mediates the delay between the speed violation and getting a ticket is one possible solution. This study examines combinations of concealment and the timing of the fine in operating speed cameras in order to evaluate the most effective one in terms of enforcing speed limits. Using a driving simulator, the driving performance of the following four experimental groups was tested: (1) overt cameras with delayed feedback, (2) overt cameras with immediate feedback, (3) covert cameras with delayed feedback, and (4) covert cameras with immediate feedback. Each of the 58 participants drove in the same scenario on three different days. The results showed that both median speed and speed variance were higher with overt than with covert cameras. Moreover, implementing a covert camera system along with immediate feedback was more conducive to drivers maintaining steady speeds at the permitted levels from the very beginning. Finally, both 'overt cameras' groups exhibit a kangaroo effect throughout the entire experiment. It can be concluded that an implementation strategy consisting of covert speed cameras combined with immediate feedback to the offender is potentially an optimal way to motivate drivers to maintain speeds at the

  14. Immediate loading with fixed full-arch prostheses in the maxilla: Review of the literature

    Science.gov (United States)

    Peñarrocha-Oltra, David; Covani, Ugo; Peñarrocha-Diago, Miguel

    2014-01-01

    Objectives: To critically review the evidence-based literature on immediate loading of implants with fixed full-arch prostheses in the maxilla to determine 1) currently recommended performance criteria and 2) the outcomes that can be expected with this procedure. Study Desing: Studies from 2001 to 2011 on immediate loading with fixed full-arch maxillary prostheses were reviewed. Clinical series with at least 5 patients and 12 months of follow-up were included. Case reports, studies with missing data and repeatedly published studies were excluded. In each study the following was assessed: type of study, implant type, number of patients, number of implants, number of implants per patient, use of post-extraction implants, minimum implant length and diameter, type of prosthesis, time until loading, implant survival rate, prosthesis survival rate, marginal bone loss, complications andmean follow-up time. Criteria for patient selection, implant primary stability and bone regeneration were also studied. Results: Thirteen studies were included, reporting a total of 2484 immediately loaded implants in 365 patients. Currently accepted performance criteria regarding patient and implant selection, and surgical and prosthetic procedures were deduced from the reviewed articles. Implant survival rates went from 87.5% to 100%, prosthesis survival rates from 93.8% to 100% and radiographic marginal bone loss from 0.8 mm to 1.6 mm.No intraoperative complications and only minor prosthetic complications were reported. Conclusions: The literature on immediate loading with fixed full-arch prostheses in the maxilla shows that a successful outcome can be expected if adequate criteria are used to evaluate the patient, choose the implant and perform the surgical and prosthetic treatment. Lack of homogeneity within studies limits the relevance of the conclusions that can be drawn, and more controlled randomized studies are necessary to enable comparison between the immediate and the

  15. Reoperation After Combined Injury of the Index Finger: Repair Versus Immediate Amputation.

    Science.gov (United States)

    Wilkens, Suzanne C; Claessen, Femke M A P; Ogink, Paul T; Moradi, Ali; Ring, David

    2016-03-01

    To identify factors associated with unplanned reoperation of severely injured index fingers and to address the number of amputations after initial repair. In this retrospective study, we included all patients older than 18 years of age who had repair or immediate amputation for combined index finger injury at 2 level I trauma centers and 1 community hospital tied to a level I trauma center between January 2004 and February 2014. Twelve patients were excluded because of inadequate follow-up. Bivariate and multivariable analyses sought factors associated with unplanned reoperation after repair and immediate amputation. Among 114 patients with combined injury, 75 were treated with repair and 39 with immediate amputation. A total of 41 patients had an unplanned reoperation, 33 after repair (44%) and 8 after immediate amputation (21%). In multivariable analysis, patients who had a reoperation for fingers other than the index finger were at risk for unplanned reoperation after repair. Women were more likely to have an unplanned reoperation than men, and patients who had a ray amputation were at risk for unplanned reoperation after immediate amputation. Six patients (18%) had amputation after initial repair. Surgeons may counsel patients that they are twice as likely to have an unplanned reoperation after a repair for combined injury of the index finger compared with an immediate amputation. Unplanned reoperations were more common among patients with injuries involving multiple fingers. Effective shared decision making is particularly important in this setting given that 1 in 5 repaired index fingers were eventually amputated. Therapeutic IV. Copyright © 2016 American Society for Surgery of the Hand. Published by Elsevier Inc. All rights reserved.

  16. A simplified protocol for the immediate loading of the edentulous arch.

    Science.gov (United States)

    Apfel, Paul S; Kopman, Jeffrey S

    2006-01-01

    Restoring dentitions with dental implants is an extremely gratifying procedure for the dental professional. However, the traditional approach of delayed loading requires surgical, prosthetic and patient management gymnastics, often necessitating extended treatment over one year, with multiple relines of fixed provisional restorations or even long periods with removable prostheses. The purpose of this article is to outline a simplified protocol for the immediate loading of the edentulous arch. By adhering to this protocol, the dental team can provide patients with an immediate functional, esthetic and fixed restoration, thereby avoiding the multitude of issues associated with delayed loading and enhancing patient satisfaction.

  17. Spurious leptomeningeal enhancement on immediate post-operative MRI for paediatric brain tumours

    Energy Technology Data Exchange (ETDEWEB)

    Widjaja, Elysa; Connolly, Daniel J.A. [Royal Hallamshire Hospital, Department of Radiology, Sheffield (United Kingdom); Gatscher, Sylvia; McMullen, John [Royal Hallamshire Hospital, Department of Neurosurgery, Sheffield (United Kingdom); Griffiths, Paul D. [University of Sheffield, Academic section of Radiology, Sheffield (United Kingdom)

    2005-03-01

    Immediate post-operative MRI has been recommended as an accurate and robust method to assess residual brain tumour. Early enhancement at the resection margin and in the dura is well recognized, but we describe two cases of enhancement in the basal cisterns on immediate post-operative MRI that resolved on follow-up. The underlying cause of the enhancement remains to be elucidated, but it should be recognized that leptomeningeal enhancement may occur after surgery and that this does not necessarily imply tumour spread. (orig.)

  18. CLINICAL CONSIDERATIONS OF DENTAL IMPLANT SYSTEM IN IMMEDIATE LOADING IMPLANT CASES

    Directory of Open Access Journals (Sweden)

    Carolina Damayanti Marpaung

    2015-06-01

    Full Text Available Immediate loading of dental implant has been researched intensively in the development of Branemark’s early concept of 2 stages implant placement. This was embarked from both patients and practiitioner’s convenience towards a simpler protocol and shorter time frame. Many recent researchers later found that micromotions derived from occlusal loading for a certain degree, instead of resulting a fibrous tissue encapsulation, can enhance the osseointegration process. Dental Implant system enhancement towards maximizing the primary stability held a key factor in Branemark’s concept development. Surgical protocol and implant design was found to give a significant contribution to the prognosis of immediate-loading implants.

  19. Contralateral Obturator Hernia Immediately after a Right Obturator Herniorrhaphy: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Oh, Soo Jin [Soonchunhyang University Cheonan Hospital College of Medicine, Cheonan (Korea, Republic of); Choi, Gyo Chang; Kim, Hyeong Soo [Soonchunhyang University Gumi Hospital College of Medicine, Gumi (Korea, Republic of)

    2010-11-15

    An obturator hernia is a very rare condition that occurs in elderly debilitated women and its nonspecific symptoms delay the diagnosis. Computed tomography is a useful tool for the early diagnosis of an obturator hernia. Previous studies report that bilateral obturator hernias comprise approximately 6% of all obturator hernias is 6%. To the best of our knowledge, there is no reported case of a contralateral obturator hernia immediately after a herniorrhaphy. We report a case of contralateral obturator hernia that occurred immediately after a right obturator herniorrhaphy

  20. Immediate virological response predicts the success of shortterm peg-interferon monotherapy for chronic hepatitis C

    Institute of Scientific and Technical Information of China (English)

    Masayoshi; Yada; Akihide; Masumoto; Naoki; Yamashita; Kenta; Motomura; Toshimasa; Koyanagi; Shigeru; Sakamoto

    2010-01-01

    AIM:To investigate the efficacy of short-term peginterferon(PEG-IFN)monotherapy for chronic hepatitis C patients who achieved an immediate virological response.METHODS:Defining an"immediate virological response(IVR)"as the loss of serum hepatitis C virus(HCV) RNA 7 d after the first administration of PEG-IFNα,we conducted a 12-wk course of PEG-IFNα2a monotherapy without the addition of ribavirin for 38 patients who had low pretreatment HCV RNA load and exhibited IVR.The patients included 21 men and 17 women...

  1. Recessive dystrophic epidermolysis bullosa--oral rehabilitation using stereolithography and immediate endosseous implants.

    Science.gov (United States)

    Oliveira, Marcio A; Ortega, Karem L; Martins, Fabiana M; Maluf, Paulo S Z; Magalhães, Marina G

    2010-01-01

    Dental management of patients with epi-dermolysis bullosa (EB) is challenging because of the severe soft tissue lesions associated with this disease. A case history is presented where two immediate endosseous implants were placed in the mandible of a patient with recessive dystrophic EB using computer-aided technology to plan the surgery and prosthetic rehabilitation. After a 24-month follow-up, the prosthesis was stable with healthy asymptomatic soft tissue around the implants. The stereolithographic model provides a precise and noninvasive copy of the mandibular and maxillary arches of patients with EB for rehabilitation of the dentition with immediate endosseous implants and a prosthesis.

  2. 19 CFR 143.34 - Procedure for electronic immediate delivery or entry.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Procedure for electronic immediate delivery or entry. 143.34 Section 143.34 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) SPECIAL ENTRY PROCEDURES Electronic Entry Filing §...

  3. 8 CFR 204.1 - General information about immediate relative and family-sponsored petitions.

    Science.gov (United States)

    2010-01-01

    ... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false General information about immediate... SECURITY IMMIGRATION REGULATIONS IMMIGRANT PETITIONS Immigrant Visa Petitions § 204.1 General information... evaluated for authenticity and credibility. Secondary evidence may include, but is not limited to, one...

  4. Skin-Sparing Mastectomy with Immediate Breast and Nipple Reconstruction: A New Technique of Nipple Reconstruction

    Directory of Open Access Journals (Sweden)

    Raffaele Serra

    2013-01-01

    Full Text Available Background. Most women with breast cancer today can be managed with breast conservation; however, some women still require mastectomy for treatment of their disease. Skin-sparing mastectomy (SSM with immediate reconstruction has emerged as a favorable option for many of these patients. The authors combined the SSM technique with the preservation of a small part of the areola with immediate nipple together with with breast reconstruction. Methods. In an 8-year-period 155 female patients (age: 20–52 years old; mean age: 37.5 years with extensive ductal intraepithelial neoplasia (DIN or invasive breast cancer were treated with areola skin sparing mastectomy with immediate nipple and breast reconstruction. Patients were followed up prospectively by the breast surgeon, the plastic surgeon, and the oncologist for complications and recurrence. Results. After treatment, only 2 cases (1.29% had a local recurrence. 8 out of 155 (5.5% patients developed early complications (infections, seroma, haematoma, and 5 out of 155 patients (3.22% developed delayed complications (implant rotation, aestethic deterioration in the post operative time period. The final aesthetic outcome was judged as positive in 150 out of 155 patients (96.78%. Conclusion. In our experience, immediate nipple reconstruction after skin-sparing mastectomy is a technically feasible procedure which can give excellent cosmetic results.

  5. Developmental Abilities to Form Chunks in Immediate Memory and its Non-Relationship to Span Development

    Directory of Open Access Journals (Sweden)

    Fabien eMathy

    2016-02-01

    Full Text Available Both adults and children --by the time they are two to three years old-- have a general ability to recode information to increase memory efficiency. This paper aims to evaluate the ability of untrained children aged six to ten years old to deploy such a recoding process in immediate memory. A large sample of 374 children were given a task of immediate serial report based on SIMON, a classic memory game made of four colored buttons (red, green, yellow, blue requiring players to reproduce a sequence of colors within which repetitions eventually occur. It was hypothesized that a primitive ability across all ages (since theoretically already available in toddlers to detect redundancies allows the span to increase whenever information can be recoded on the fly. The chunkable condition prompted the formation of chunks based on the perceived structure of color repetition within to-be-recalled sequences of colors. Our result shows a similar linear improvement of memory span with age for both chunkable and non-chunkable conditions. The amount of information retained in immediate memory systematically increased for the groupable sequences across all age groups, independently of the average age-group span that was measured on sequences that contained fewer repetitions. This result shows that chunking gives young children an equal benefit as older children. We discuss the role of recoding in the expansion of capacity in immediate memory and the potential role of data compression in the formation of chunks in long-term memory.

  6. Immediate and Delayed Recall of Lecture Material as a Function of Note Taking.

    Science.gov (United States)

    Weiland, Andrea; Kingsbury, Steven J.

    1979-01-01

    Statistical analysis indicates that a note-taking group performed significantly better overall than a no-notes group on both an immediate and a delayed quiz although both groups showed a significant decline in performance in the latter quiz. (JMF)

  7. Timing matters: the impact of immediate and delayed feedback on artificial language learning.

    Science.gov (United States)

    Opitz, Bertram; Ferdinand, Nicola K; Mecklinger, Axel

    2011-01-01

    In the present experiment, we used event-related potentials (ERP) to investigate the role of immediate and delayed feedback in an artificial grammar learning (AGL) task. Two groups of participants were engaged in classifying non-word strings according to an underlying rule system, not known to the participants. Visual feedback was provided after each classification either immediately or with a short delay of 1 s. Both groups were able to learn the artificial grammar system as indicated by an increase in classification performance. However, the gain in performance was significantly larger for the group receiving immediate feedback as compared to the group receiving delayed feedback. Learning was accompanied by an increase in P300 activity in the ERP for delayed as compared to immediate feedback. Irrespective of feedback delay, both groups exhibited learning related decreases in the feedback-related positivity (FRP) elicited by positive feedback only. The feedback-related negativity (FRN), however, remained constant over the course of learning. These results suggest, first, that delayed feedback is less effective for AGL as task requirements are very demanding, and second, that the FRP elicited by positive prediction errors decreases with learning while the FRN to negative prediction errors is elicited in an all-or-none fashion by negative feedback throughout the entire experiment.

  8. 77 FR 24742 - In the Matter of ABSG Consulting Inc. Confirmatory Order (Effective Immediately)

    Science.gov (United States)

    2012-04-25

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION In the Matter of ABSG Consulting Inc. Confirmatory Order (Effective Immediately) I ABSG Consulting Inc. (ABSG) is an independently owned and operated risk, safety, and integrity management company...

  9. Factors influencing ridge alterations following immediate implant placement into extraction sockets.

    Science.gov (United States)

    Ferrus, Jorge; Cecchinato, Denis; Pjetursson, E Bjarni; Lang, Niklaus P; Sanz, Mariano; Lindhe, Jan

    2010-01-01

    To identify factors that may influence ridge alterations occurring at the buccal aspect of the extraction site following immediate implant placement. In 93 subjects, single-tooth implants were placed immediately into extraction sockets in the maxilla (tooth locations 15-25). A series of measurements describing the extraction site were made immediately after implant installation and at re-entry, 16 weeks later. The implant sites were stratified according to four factors: (i) implant location (anterior/posterior), (ii) cause of tooth extraction (periodontitis/non-periodontitis), (iii) thickness of the buccal bone walls ( 1 mm) and (iv) the dimension of the horizontal buccal gap ( 1 mm). (i) The location where the implant was placed (anterior/posterior) as well as (ii) the thickness of the buccal bone crest and (iii) the size of the horizontal buccal gap significantly influenced the amount of hard tissue alteration that occurred during a 4-month period of healing. At implant sites in the premolar segment, the fill of the horizontal gap was more pronounced than in the incisor-canine segment, while the vertical crest reduction was significantly smaller. Furthermore, at sites where the buccal bone wall was thick (>1 mm) and where the horizontal gap was large (>1 mm), the degree of gap fill was substantial. The thickness of the buccal bone wall as well as the dimension of the horizontal gap influenced the hard tissue alterations that occur following immediate implant placement into extraction sockets.

  10. The per-protocol effect of immediate vs. deferred ART initiation in the START randomized trial

    DEFF Research Database (Denmark)

    Lodi, Sara; Sharma, Shweta; Lundgren, Jens D;

    2016-01-01

    OBJECTIVE: The START trial found a lower risk of a composite clinical outcome in HIV-positive individuals assigned to immediate initiation of antiretroviral therapy (ART) compared with those assigned to deferred initiation. However, 30% of those assigned to deferred initiation started ART earlier...

  11. Preliminary assessment of the electromagnetic environment in the immediate vicinity of the ETA accelerator

    Energy Technology Data Exchange (ETDEWEB)

    Cabayan, H.S.; Bogdan, E.; Zicker, J.; Wythe, D.; Burke, G.J.

    1980-04-01

    The electromagnetic fields in the immediate vicinity of the Experimental Test Accelerator (ETA) at the Lawrence Livermore Laboratory have been characterized. Various EM sensors that cover the frequency band from the very low frequencies up into the GHz region have been used. The report describes in detail the probes, the test set-up and the data processing techniques.

  12. 77 FR 34998 - Darryl J. Mohr, M.D.; Affirmance of Immediate Suspension Order

    Science.gov (United States)

    2012-06-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE Drug Enforcement Administration Darryl J. Mohr, M.D.; Affirmance of Immediate Suspension Order On January 20, 2011... a doctor shopper and then all of a sudden no pharmacy is gonna give you any medication.''...

  13. Immediate Single-stage Endoscopic Latissimus Dorsi Breast and Nipple Reconstruction

    Directory of Open Access Journals (Sweden)

    Joaquim Muñoz i Vidal, MD

    2014-03-01

    Full Text Available Summary: Immediate breast reconstruction usually is a multistep surgical treatment. We introduce a new technique with positive results that reduces the reconstruction to 1 single step. This new technique promises to reduce patient consequences from multistaged procedures while reducing the costs. A retrospective review of 7 patients is presented.

  14. 78 FR 77512 - Self-Regulatory Organizations; Chicago Mercantile Exchange Inc.; Notice of Filing and Immediate...

    Science.gov (United States)

    2013-12-23

    ... Interest Rate Swaps (``IRS Manual''). II. Self-Regulatory Organization's Statement of the Purpose of, and... Manual (as described above) that are limited to CME's business as a derivatives clearing organization... COMMISSION Self-Regulatory Organizations; Chicago Mercantile Exchange Inc.; Notice of Filing and Immediate...

  15. 78 FR 9763 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-02-11

    ... non- Member to connect into the Exchange at the data centers where Exchange servers are located... From the Federal Register Online via the Government Publishing Office ] SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

  16. 75 FR 78791 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2010-12-16

    ...-member to literally plug into the Exchange at the data centers where the Exchange's servers are located... From the Federal Register Online via the Government Publishing Office ] SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

  17. 78 FR 9749 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-02-11

    ... non- Member to connect into the Exchange at the data centers where Exchange servers are located... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

  18. 75 FR 78794 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2010-12-16

    ...-member to literally plug into the Exchange at the data centers where the Exchange's servers are located... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

  19. 78 FR 19350 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-03-29

    ... physical ports to access the Exchange at the primary data center where the Exchange's servers are located... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

  20. Immediate loading of two implants with a mandibular implant-retained overdenture: a new treatment protocol

    NARCIS (Netherlands)

    Stoker, G.T.; Wismeijer, D.

    2011-01-01

    PURPOSE: The aim of this study was to present the clinical outcomes of the immediate loading of two bar-splinted implants retaining a mandibular overdenture. MATERIALS AND METHODS: In a clinical trial, 124 edentulous patients were treated according to a new treatment concept, which involves the imme

  1. 76 FR 62126 - Self-Regulatory Organizations; Chicago Stock Exchange, Inc.; Notice of Filing and Immediate...

    Science.gov (United States)

    2011-10-06

    ... Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Eliminate Certain... Statement of the Terms of Substance of the Proposed Rule Change CHX proposes to amend its rules to eliminate... waiver will allow the Exchange to implement the change right away. The proposed rule change...

  2. 75 FR 80097 - Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule...

    Science.gov (United States)

    2010-12-21

    ... COMMISSION Self-Regulatory Organizations; Notice of Filing and Immediate Effectiveness of Proposed Rule Change by NYSE Amex LLC Establishing Strike Price Intervals of $1 and Increasing Position and Exercise Limits With Respect to Options on the KBW Bank Index December 15, 2010. Pursuant to Section 19(b)(1)...

  3. Immediate rather than delayed memory impairment in older adults with latent toxoplasmosis.

    Science.gov (United States)

    Mendy, Angelico; Vieira, Edgar R; Albatineh, Ahmed N; Gasana, Janvier

    2015-03-01

    The neurotropic parasite Toxoplasma gondii infects one third of the world population, but its effect on memory remains ambiguous. To examine a potential relationship of the infection with immediate and delayed memory, a population-based study was conducted in 4485 participants of the Third National Health and Nutrition Examination Survey aged 60years and older. Serum anti-Toxoplasma IgG antibodies were measured by enzyme immune assay and verbal memory was assessed using the Mini-Mental State Examination and the East Boston Memory Test. The prevalence of latent toxoplasmosis was 41%; in one way analysis of variance, anti-Toxoplasma IgG antibody levels significantly differed across tertiles for immediate (P=0.006) but not delayed memory scores (P=0.22). In multinomial logistic regression adjusting for covariates, Toxoplasma seropositivity was associated with lower immediate memory performance (OR: 0.65, 95% CI: 0.44, 0.97 for medium tertile and OR: 0.61, 95% CI: 0.37, 0.98 for highest tertile in reference to the lowest tertile), especially in non-Hispanic Whites (OR: 0.56, 95% CI: 0.36, 0.88 for medium tertile and OR: 0.51, 95% CI: 0.30, 0.87 for highest tertile in reference to the lowest tertile). However, no relationship with delayed memory was observed. In conclusion, latent toxoplasmosis is widespread in older adults and may primarily affect immediate rather than delayed memory, particularly in White Americans.

  4. Influence of immediate loading on provisional restoration in dental implant stability

    Science.gov (United States)

    Ikbal, M.; Odang, R. W.; Indrasari, M.; Dewi, R. S.

    2017-08-01

    The success of dental implant treatment is determined by the primary stability at placement. One factor that could influence this stability is occlusal loading through provisional restoration. Two types of loading protocols are usually used: immediate and delayed loading. However, some controversies remain about the influence of occlusal loading on implant stability. Therefore, the influence of immediate loading on implant stability must be studied. An animal study was conducted by placing nine dental implants in the mandibular jaw of three Macaca fascicularis. Provisional restorations with various occlusal contacts (no, light, and normal contact) were placed on the implant. The implant stability was measured using the Ostell ISQ three times: immediately (baseline) and at the first and second months after implant placement. The implant stability between implants with no and normal occlusal contact as well as light and normal occlusal contact showed significant differences (p 0.05) in implant stability was seen at the baseline and the first and second months after implant placement for all occlusal contact groups. Immediate loading influenced the implant stability, and provisional restoration of implant without occlusal contact showed the highest implant stability.

  5. Immediate placement of dental implants in the esthetic zone : a systematic review and pooled analysis

    NARCIS (Netherlands)

    Slagter, Kirsten W; den Hartog, Laurens; Bakker, Nicolaas A; Vissink, Arjan; Meijer, Henny J A; Raghoebar, Gerry M

    Background: Research interest on immediate placement of dental implants has shifted from implant survival toward optimal preservation of soft and hard tissues. The aim of this study is to systematically assess the condition of implant survival, peri-implant hard and soft tissue changes, esthetic

  6. Bone changes in ridge split with immediate implant placement: A systematic review

    Directory of Open Access Journals (Sweden)

    Mohamed M. Dohiem

    2015-12-01

    Conclusion: Alveolar ridge splitting might be considered a predictable approach that demonstrates a high implant survival rate, adequate horizontal bone gain and minimal postoperative complications. Weak evidence showed the effect of flap design and immediate implantation on marginal bone loss and survival rate.

  7. Evaluation of the Immediate and Subsequent Effects of Response Interruption and Redirection on Vocal Stereotypy

    Science.gov (United States)

    Schumacher, Brittany I.; Rapp, John T.

    2011-01-01

    We evaluated 2 3-component multiple-schedule sequences--a response interruption and redirection (RIRD) treatment sequence and a no-interaction control sequence--using a multielement design. With this design, we were able to evaluate the immediate and subsequent effects of RIRD on 2 participants' vocal stereotypy. For both participants, RIRD…

  8. Melt-processed polymeric cellular dosage forms for immediate drug release.

    Science.gov (United States)

    Blaesi, Aron H; Saka, Nannaji

    2015-12-28

    The present immediate-release solid dosage forms, such as the oral tablets and capsules, comprise granular matrices. While effective in releasing the drug rapidly, they are fraught with difficulties inherent in processing particulate matter. By contrast, liquid-based processes would be far more predictable; but the standard cast microstructures are unsuited for immediate-release because they resist fluid percolation and penetration. In this article, we introduce cellular dosage forms that can be readily prepared from polymeric melts by incorporating the nucleation, growth, and coalescence of microscopic gas bubbles in a molding process. We show that the cell topology and formulation of such cellular structures can be engineered to reduce the length-scale of the mass-transfer step, which determines the time of drug release, from as large as the dosage form itself to as small as the thickness of the cell wall. This allows the cellular dosage forms to achieve drug release rates over an order of magnitude faster compared with those of cast matrices, spanning the entire spectrum of immediate-release and beyond. The melt-processed polymeric cellular dosage forms enable predictive design of immediate-release solid dosage forms by tailoring microstructures, and could be manufactured efficiently in a single step.

  9. Immediate liposuction could shorten the time for endoscopic axillary lymphadenectomy in breast cancer patients.

    Science.gov (United States)

    Shi, Fujun; Huang, Zonghai; Yu, Jinlong; Zhang, Pusheng; Deng, Jianwen; Zou, Linhan; Zhang, Cheng; Luo, Yunfeng

    2017-01-31

    Endoscopic axillary lymphadenectomy (EALND) was introduced to clinical work to reduce side effects of conventional axillary lymphadenectomy, while the lipolysis and liposuction of EALND made the process consume more time. The aim of the study was to determine whether immediate liposuction after tumescent solution injection to the axilla could shorten the total time of EALND. Fifty-nine patients were enrolled in the study, 30 of them received EALND with traditional liposuction method (TLM), and the rest 29 patients received EALND with immediate liposuction method (ILM). The operation time, cosmetic result, drainage amount, and hospitalization time of the two groups were compared. The median EALND operation time of TLM group and ILM group were 68 and 46 min, respectively, the difference was significant (P  0.05). Our work suggests immediate liposuction could shorten the endoscopic axillary lymphadenectomy process, and this method would not compromise the operation results. However, due to the limitations of the research, more work needs to be done to prove the availability and feasibility of immediate liposuction.

  10. Duality and Stationary Distributions of the “Immediate Exchange Model” and Its Generalizations

    NARCIS (Netherlands)

    Van Ginkel, B.; Redig, F.H.J.; Sau, F.

    2016-01-01

    We study the “Immediate Exchange Model”, a wealth distribution model introduced in Heinsalu and Patriarca (Eur Phys J B 87:170, 2014). We prove that the model has a discrete dual, where the duality functions are natural polynomials associated to the Gamma distribution with shape parameter 2 and are

  11. 77 FR 37720 - Options Price Reporting Authority; Notice of Filing and Immediate Effectiveness of Proposed...

    Science.gov (United States)

    2012-06-22

    ... COMMISSION Options Price Reporting Authority; Notice of Filing and Immediate Effectiveness of Proposed Amendment to the Plan To Revise the Definition of the Term ``Nonprofessional'' June 15, 2012. Pursuant to... hereby given that on May 31, 2012, the Options Price Reporting Authority (``OPRA'') submitted to the...

  12. Immediate effects of hip mobilization with movement in patients with hip osteoarthritis: A randomised controlled trial.

    Science.gov (United States)

    Beselga, Carlos; Neto, Francisco; Alburquerque-Sendín, Francisco; Hall, Toby; Oliveira-Campelo, Natália

    2016-04-01

    Mobilization with movement (MWM) has been shown to reduce pain, increase range of motion (ROM) and physical function in a range of different musculoskeletal disorders. Despite this evidence, there is a lack of studies evaluating the effects of MWM for hip osteoarthritis (OA). To determine the immediate effects of MWM on pain, ROM and functional performance in patients with hip OA. Randomized controlled trial with immediate follow-up. Forty consenting patients (mean age 78 ± 6 years; 54% female) satisfied the eligibility criteria. All participants completed the study. Two forms of MWM techniques (n = 20) or a simulated MWM (sham) (n = 20) were applied. pain recorded by numerical rating scale (NRS). hip flexion and internal rotation ROM, and physical performance (timed up and go, sit to stand, and 40 m self placed walk test) were assessed before and after the intervention. For the MWM group, pain decreased by 2 points on the NRS, hip flexion increased by 12.2°, internal rotation by 4.4°, and functional tests were also improved with clinically relevant effects following the MWM. There were no significant changes in the sham group for any outcome variable. Pain, hip flexion ROM and physical performance immediately improved after the application of MWM in elderly patients suffering hip OA. The observed immediate changes were of clinical relevance. Future studies are required to determine the long-term effects of this intervention. Copyright © 2015 Elsevier Ltd. All rights reserved.

  13. Evaluation of success rates of immediate and delayed implants after tooth extraction

    Institute of Scientific and Technical Information of China (English)

    Baris Simsek; Sebnem Simsek

    2003-01-01

    Objective To evaluate the success rates of immediate and delayed placement of implants with respect to the causes of tooth extraction and implant positions. Methods A total of 310 dental implants (immediate implants∶ delayed implants=76∶ 234) were inserted into 80 patients. The types, sizes and positions of the implants and the causes of tooth extraction were recorded. We then investigated the relationship of implant loss with the causes of tooth extraction and placement methods. Results A higher failure rate was found for the implants in the posterior region of the maxilla, and when periodontitis was cited as a reason for tooth extraction. The overall success rates were 93.4% and 95.7% in the immediate and delayed implant placement groups, respectively, after a 2-year follow-up. No obvious relationship of success rate was observed with the implant placement method, cause of tooth extaction, and implants' position. Conclusion The immediate placement of implants into fresh extraction sockets could offer advantages over the delayed implant placement. It seems to be a safe and predictable method for patients.

  14. IMMEDIATE AND DELAYED HYPERSENSITIVITY REACTIONS TO LATEX GLOVES IN A DENTAL STUDENT. A case report.

    Directory of Open Access Journals (Sweden)

    Iliyana Stoeva

    2011-08-01

    Full Text Available The article presents a case of dental student with immediate and delayed hypersensitivity reaction to latex gloves. Symptoms appeared during the second year of regularly using of latex gloves. The student was with no history of allergies and no previous exposure to latex products.

  15. Reliability of Reconstructed Breast Flap after Chemotherapy and Radiotherapy in Immediate Breast Reconstruction

    Directory of Open Access Journals (Sweden)

    Keun-Cheol Lee

    2012-09-01

    Full Text Available BackgroundPostmastectomy adjuvant therapy is used to prevent locoregional recurrence and improve overall breast cancer specific survival rates. However, it can adversely affect the cosmetic results of reconstruction. Therefore, the authors examined flap stability and patients' satisfaction with immediate breast reconstruction after adjuvant therapy.MethodsWe retrospectively reviewed the medical records of 204 patients from January 2006 to November 2011. For complication rates, the authors categorized the patients who underwent the immediate breast reconstruction into 4 groups: adjuvant chemotherapy and radiotherapy group, adjuvant chemotherapy only group, adjuvant radiotherapy only group, and the group that did not undergo adjuvant therapy. For comparison of patients' satisfaction, the study was performed with an additional 16 patients who had undergone delayed breast reconstruction.ResultsRegarding complication rates, the group that had undergone adjuvant therapy showed no significant difference compared to the group that did not undergo adjuvant therapy. In evaluating the patients' satisfaction, there was no significant difference.ConclusionsEven after adjuvant therapy, immediate breast reconstruction showed good results with respect to flap stability and patients' satisfaction. Immediate breast reconstruction and adjuvant therapy is a safe and useful option for breast cancer patients.

  16. Reliability of Reconstructed Breast Flap after Chemotherapy and Radiotherapy in Immediate Breast Reconstruction

    Directory of Open Access Journals (Sweden)

    Keun-Cheol Lee

    2012-09-01

    Full Text Available Background Postmastectomy adjuvant therapy is used to prevent locoregional recurrenceand improve overall breast cancer specific survival rates. However, it can adversely affectthe cosmetic results of reconstruction. Therefore, the authors examined flap stability andpatients’ satisfaction with immediate breast reconstruction after adjuvant therapy.Methods We retrospectively reviewed the medical records of 204 patients from January2006 to November 2011. For complication rates, the authors categorized the patients whounderwent the immediate breast reconstruction into 4 groups: adjuvant chemotherapyand radiotherapy group, adjuvant chemotherapy only group, adjuvant radiotherapy onlygroup, and the group that did not undergo adjuvant therapy. For comparison of patients’satisfaction, the study was performed with an additional 16 patients who had undergonedelayed breast reconstruction.Results Regarding complication rates, the group that had undergone adjuvant therapyshowed no significant difference compared to the group that did not undergo adjuvanttherapy. In evaluating the patients’ satisfaction, there was no significant difference.Conclusions Even after adjuvant therapy, immediate breast reconstruction showed goodresults with respect to flap stability and patients’ satisfaction. Immediate breast reconstructionand adjuvant therapy is a safe and useful option for breast cancer patients.

  17. The Immediate Impacts of Preschool Attendance on Turkish Children's Mathematics Achievement

    Science.gov (United States)

    Aslan, Durmus; Aktas Arnas, Yasare

    2015-01-01

    This study was conducted to investigate the immediate impacts of preschool attendance on Turkish children's mathematics achievement. The participants were 200 children who attended or did not attend preschool. The number and operation task and the geometric shapes sorting task were used as the data collection tools. The children who attended…

  18. 75 FR 78783 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2010-12-16

    ... and open market and a national market system and, in general, to protect investors and the public... COMMISSION Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Amend EDGA Rule 11.14 To Extend the Operation of a Pilot Pursuant to...

  19. 75 FR 78787 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2010-12-16

    ... and open market and a national market system and, in general, to protect investors and the public... COMMISSION Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Amend EDGX Rule 11.14 To Extend the Operation of a Pilot Pursuant to...

  20. 77 FR 4608 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2012-01-30

    ... of a free and open market and a national market system and, in general, to protect investors and the... COMMISSION Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Amend EDGA Rule 11.14 To Extend the Operation of the Single Stock...

  1. 77 FR 4606 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2012-01-30

    ... of a free and open market and a national market system and, in general, to protect investors and the... COMMISSION Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Amend EDGX Rule 11.14 To Extend the Operation of the Single Stock...

  2. Adolescents Prefer More Immediate Rewards when in the Presence of Their Peers

    Science.gov (United States)

    O'Brien, Lia; Albert, Dustin; Chein, Jason; Steinberg, Laurence

    2011-01-01

    Adolescents take more risks in the presence of their peers, but the mechanism through which peer presence affects risky decision-making is unknown. We propose that the presence of peers increases the salience of the immediate rewards of a risky choice. The current study examined the effect of peer presence on reward sensitivity in a sample of 100…

  3. The Functions of Immediate Echolalia in Autistic Children: A Developmental Perspective.

    Science.gov (United States)

    McEvoy, Robin E.; And Others

    1988-01-01

    The study examined differences in the use of immediate echolalia by 18 children (ages 4-12) with autism at different stages of language development. Percentage of echolalic language was high at early stages of language development but decreased as language skills improved. (Author/DB)

  4. Does Emotion Help or Hinder Immediate Memory?: Arousal Versus Priority-Binding Mechanisms

    Science.gov (United States)

    Hadley, Christopher B.; MacKay, Donald G.

    2006-01-01

    People recall taboo words better than neutral words in many experimental contexts. The present rapid serial visual presentation (RSVP) experiments demonstrated this taboo-superiority effect for immediate recall of mixed lists containing taboo and neutral words matched for familiarity, length, and category coherence. Under binding theory (MacKay et…

  5. Immediate placement of dental implants in the esthetic zone : a systematic review and pooled analysis

    NARCIS (Netherlands)

    Slagter, Kirsten W; den Hartog, Laurens; Bakker, Nicolaas A; Vissink, Arjan; Meijer, Henny J A; Raghoebar, Gerry M

    2014-01-01

    Background: Research interest on immediate placement of dental implants has shifted from implant survival toward optimal preservation of soft and hard tissues. The aim of this study is to systematically assess the condition of implant survival, peri-implant hard and soft tissue changes, esthetic out

  6. Representation of Item Position in Immediate Serial Recall: Evidence from Intrusion Errors

    Science.gov (United States)

    Fischer-Baum, Simon; McCloskey, Michael

    2015-01-01

    In immediate serial recall, participants are asked to recall novel sequences of items in the correct order. Theories of the representations and processes required for this task differ in how order information is maintained; some have argued that order is represented through item-to-item associations, while others have argued that each item is…

  7. Immediate-Release Methylphenidate for ADHD in Children with Comorbid Chronic Multiple Tic Disorder

    Science.gov (United States)

    Gadow, Kenneth D.; Sverd, Jeffrey; Nolan, Edith E.; Sprafkin, Joyce; Schneider, Jayne

    2007-01-01

    Objective: To examine the safety and efficacy of immediate-release methylphenidate (MPH-IR) for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children (ages 6-12 years) with Tourette's syndrome (96%) or chronic motor tic disorder (4%). Method: Two cohorts of prepubertal children (N = 71) received placebo and three doses of…

  8. 77 FR 77157 - Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing and Immediate...

    Science.gov (United States)

    2012-12-31

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; The Options Clearing Corporation; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Amend Interpretative Guidance Relating to the Adjustment of Stock Options and Single Stock Futures...

  9. Delayed healing at transurethral resection of bladder tumour sites after immediate postoperative mitomycin C instillation

    DEFF Research Database (Denmark)

    Aagaard, Mark F; Mogensen, Karin; Hermann, Gregers G

    2014-01-01

    The most common reactions to mitomycin C are dysuria and drug-related palmar and genital desquamation. This report describes two cases of delayed healing of the mucosa at resection sites after transurethral resection of bladder tumours, most likely due to immediate postoperative mitomycin C...

  10. 78 FR 37644 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-06-21

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Related to Fees for Use of BATS Exchange, Inc. June 17, 2013. Pursuant to...\\ notice is hereby given that on June 4, 2013, BATS Exchange, Inc. (the ``Exchange'' or ``BATS'')...

  11. 77 FR 58195 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2012-09-19

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Related to Fees for Use of BATS Exchange, Inc. September 13, 2012. Pursuant... thereunder,\\2\\ notice is hereby given that on August 31, 2012, BATS Exchange, Inc. (the ``Exchange''...

  12. 78 FR 77736 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-12-24

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of a Proposed Rule Change To Modify BATS Options Market Maker Continuous Quoting Obligation Rules... Rule 19b-4 thereunder,\\2\\ notice is hereby given that on December 5, 2013, BATS Exchange, Inc....

  13. 78 FR 8617 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-02-06

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Amend BATS Rules Related to Price Sliding Functionality January 31, 2013... thereunder,\\2\\ notice is hereby given that on January 25, 2013, BATS Exchange, Inc. (the ``Exchange''...

  14. 76 FR 26331 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2011-05-06

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of a Proposed Rule Change To Extend the Trading Hours of BATS Options for Certain Products May 2... 19b-4 thereunder,\\2\\ notice is hereby given that, on April 26, 2011, BATS Exchange, Inc....

  15. 76 FR 1205 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2011-01-07

    ... (April 7, 2010), 75 FR 19449 (April 14, 2010) (SR-ISE-2010-25)(notice of filing and immediate... Exchange Act Release No. 61987 (April 27, 2010), 75 FR 24771 (May 5, 2010) (SR-C2-2010-001)(notice of... any new fees. \\14\\ See Securities Exchange Act Release No. 57253 (February 1, 2008), 73 FR...

  16. 78 FR 51235 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-08-20

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Related to Fees for Use of BATS Exchange, Inc. August 14, 2013. Pursuant to...\\ notice is hereby given that on August 7, 2013, BATS Exchange, Inc. (the ``Exchange'' or ``BATS'')...

  17. 76 FR 1208 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2011-01-07

    ... Release Nos. 62663 (August 9, 2010), 75 FR 49543 (August 13, 2010) (SR-NASDAQ-2010-077) (order approving... (August 10, 2010), 75 FR 50020 (August 16, 2010) (SR-EDGA-2010-06) (order approving fees for both 1G and... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate...

  18. 78 FR 62804 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-10-22

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Related to Fees for Use of BATS Exchange, Inc. October 11, 2013. Pursuant to...\\ notice is hereby given that on October 1, 2013, BATS Exchange, Inc. (the ``Exchange'' or ``BATS'')...

  19. 78 FR 7826 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-02-04

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Amend BATS Rules in Connection With the Elimination of Discretionary Orders for BATS Options January 29, 2013. Pursuant to Section 19(b)(1) of the Securities Exchange Act...

  20. 75 FR 66170 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2010-10-27

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Related to Fees for Use of BATS Exchange, Inc. October 21, 2010. Pursuant to...\\ notice is hereby given that on October 14, 2010, BATS Exchange, Inc. (``BATS'' or the ``Exchange'')...

  1. 77 FR 35735 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2012-06-14

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Related to Fees for Use of BATS Exchange, Inc. June 8, 2012. Pursuant to... is hereby given that on May 31, 2012, BATS Exchange, Inc. (the ``Exchange'' or ``BATS'') filed...

  2. 76 FR 9841 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2011-02-22

    ... FR 51295 (August 19, 2010) (order approving application of BATS Y-Exchange, Inc. for registration as... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Amend BATS Rule 11.13, Entitled ``Order Execution'' February 15,...

  3. 76 FR 13243 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2011-03-10

    ... Release No. 61869 (April 7, 2010), 75 FR 19449 (April 14, 2010) (SR-ISE-2010-25) (notice of filing and... month); Securities Exchange Act Release No. 61987 (April 27, 2010), 75 FR 24771 (May 5, 2010) (SR-C2...), 73 FR 7352 (February 7, 2008) (SR-Phlx-2008-08) (notice of filing and immediate effectiveness...

  4. 76 FR 57092 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2011-09-15

    ... Act Release No. 65133 (August 15, 2011), 76 FR 52032 (August 19, 2011) (SR-BATS-2011-029). The... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Offer a Bulk-Quoting Interface To All Users of BATS Options September...

  5. 78 FR 51261 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-08-20

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Related to Fees for Use of BATS Exchange, Inc. August 14, 2013. Pursuant to...\\ notice is hereby given that on August 1, 2013, BATS Exchange, Inc. (the ``Exchange'' or ``BATS'')...

  6. 78 FR 61422 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-10-03

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of a Proposed Rule Change To Modify the Trading Halt Rule of BATS Options September 27, 2013... thereunder,\\2\\ notice is hereby given that, on September 20, 2013, BATS Exchange, Inc. (the ``Exchange''...

  7. 77 FR 23307 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2012-04-18

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Related to Fees for Use of BATS Exchange, Inc. April 12, 2012. Pursuant to... is hereby given that on April 2, 2012, BATS Exchange, Inc. (the ``Exchange'' or ``BATS'') filed...

  8. 77 FR 35719 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2012-06-14

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Adopt Rules Related to Risk Management Functionality for BATS Options June... Rule 19b-4 thereunder,\\2\\ notice is hereby given that on June 1, 2012, BATS Exchange, Inc....

  9. 76 FR 44388 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2011-07-25

    ...), 75 FR 47335 (August 5, 2010) (SR-BATS-2010-020) (notice of filing and immediate effectiveness...), 76 FR 8793 (February 15, 2011) (SR-Phlx-2010-183) (order granting approval of expansion of short term... Exchange Act Release Nos. 64009 (March 2, 2011), 76 FR 12771 (March 8, 2011) (SR-BX-2011-014) (notice...

  10. 75 FR 66183 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2010-10-27

    ...), 75 FR 51295 (August 19, 2010) (order approving application of BATS Y-Exchange, Inc. for registration... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change by BATS Exchange, Inc. To Amend BATS Rule 11.13, Entitled ``Order...

  11. 76 FR 50803 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2011-08-16

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Related to Fees for Use of BATS Exchange, Inc. August 10, 2011. Pursuant to...\\ notice is hereby given that on July 29, 2011, BATS Exchange, Inc. (the ``Exchange'' or ``BATS'')...

  12. 78 FR 23965 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-04-23

    ... Securities Exchange Act Release No. 68752 (January 29, 2013), 78 FR 7826 (February 4, 2013) (SR-BATS-2013-003... Release No. 69121 (March 12, 2013), 78 FR 16750 (March 18, 2013) (SR-BATS-2013-014) (notice of filing and... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate...

  13. 77 FR 5588 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2012-02-03

    ... forth below. \\6\\ See Securities Exchange Act Release No. 65619 (October 25, 2011), 76 FR 67238 (October... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Related to Fees for Use of BATS Exchange, Inc. January 30, 2012. Pursuant...

  14. 75 FR 20418 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2010-04-19

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Related to Fees for Use of BATS Exchange, Inc. April 9, 2010. Pursuant to...\\ notice is hereby given that on March 31, 2010, BATS Exchange, Inc. (the ``Exchange'' or ``BATS'')...

  15. 75 FR 27847 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2010-05-18

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Related to Fees for Use of BATS Exchange, Inc. May 11, 2010. Pursuant to...\\ notice is hereby given that on May 4, 2010, BATS Exchange, Inc. (the ``Exchange'' or ``BATS'') filed...

  16. 78 FR 56955 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-09-16

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Related to Fees for Use of BATS Exchange, Inc. September 10, 2013. Pursuant... thereunder,\\2\\ notice is hereby given that on August 30, 2013, BATS Exchange, Inc. (the ``Exchange''...

  17. 75 FR 11951 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2010-03-12

    ... equity options on the Exchange. See Securities Exchange Act Release No. 61419 (January 26, 2010), 75 FR... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Related to Fees for Use of BATS Exchange, Inc. March 4, 2010. Pursuant...

  18. 78 FR 16750 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-03-18

    ...'').\\5\\ \\5\\ See Securities Exchange Act Release No. 67091 (May 31, 2012), 77 FR 33498 (June 6, 2012) (the... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Modify the Operation of Market Orders for BATS Options March 12,...

  19. 76 FR 20414 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2011-04-12

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Related to Fees for Use of BATS Exchange, Inc. April 6, 2011. Pursuant to...\\ notice is hereby given that, on April 1, 2011, BATS Exchange, Inc. (the ``Exchange'' or ``BATS'')...

  20. 78 FR 53814 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-08-30

    ... (July 30, 2013), 78 FR 47469 (Aug. 5, 2013) (SR-CBOE-2013-078); Securities Exchange Act Release No... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of a Proposed Rule Change Related to Registration and Continuing Education Fees for BATS...

  1. 77 FR 50199 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2012-08-20

    ... Securities Exchange Act Release No. 67093 (June 1, 2012), 77 FR 33798 (June 7, 2012) (SR-BATS-2012-018). \\10... Exchange at $10.11. See Securities Exchange Act Release No. 64475 (May 12, 2011), 76 FR 28830, 28832 (May... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate...

  2. 76 FR 12155 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2011-03-04

    ..., 2009), 74 FR 11386 (March 17, 2009). In order to allow Members sufficient time to review and complete... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness of Proposed Rule Change by BATS Exchange, Inc. to Adopt BATS Rule 11.21, entitled ``Input of...

  3. Immediate Learner Repair and Its Relationship with Learning Targeted Forms in Dyadic Interaction

    Science.gov (United States)

    Nassaji, Hossein

    2011-01-01

    This study investigated the relationship between immediate learner repair in response to interactional feedback and learning targeted forms. In particular, the study examined and compared the relationship between two major types of repair: learner-generated self-repair following elicitations and teacher-generated repair following recasts. It also…

  4. Immediate incubation of blood cultures outside routine laboratory hours of operation accelerates antibiotic switching

    NARCIS (Netherlands)

    J.J. Kerremans (Jos); A.K. van der Bij (Akke); W.H.F. Goessens (Wil); H.A. Verbrugh (Henri); M.C. Vos (Margreet)

    2009-01-01

    textabstractThe aim of this prospective randomized controlled clinical trial was to assess the impact of immediate incubation of blood cultures delivered to the laboratory outside its hours of operation on turnaround times, antibiotic prescription practices, and patient outcomes. A continuously moni

  5. The Immediate Impacts of Preschool Attendance on Turkish Children's Mathematics Achievement

    Science.gov (United States)

    Aslan, Durmus; Aktas Arnas, Yasare

    2015-01-01

    This study was conducted to investigate the immediate impacts of preschool attendance on Turkish children's mathematics achievement. The participants were 200 children who attended or did not attend preschool. The number and operation task and the geometric shapes sorting task were used as the data collection tools. The children who attended…

  6. Semantic Interference in Immediate and Delayed Naming and Reading: Attention and Task Decisions

    Science.gov (United States)

    Piai, Vitoria; Roelofs, Ardi; Schriefers, Herbert

    2011-01-01

    Disagreement exists about whether lexical selection in word production is a competitive process. Competition predicts semantic interference from distractor words in immediate but not in delayed picture naming. In contrast, Janssen, Schirm, Mahon, and Caramazza (2008) obtained semantic interference in delayed picture naming when participants had to…

  7. Improvement of Processing Speed in Executive Function Immediately following an Increase in Cardiovascular Activity

    Directory of Open Access Journals (Sweden)

    Nicoladie D. Tam

    2013-01-01

    Full Text Available This study aims to identify the acute effects of physical exercise on specific cognitive functions immediately following an increase in cardiovascular activity. Stair-climbing exercise is used to increase the cardiovascular output of human subjects. The color-naming Stroop Test was used to identify the cognitive improvements in executive function with respect to processing speed and error rate. The study compared the Stroop results before and immediately after exercise and before and after nonexercise, as a control. The results show that there is a significant increase in processing speed and a reduction in errors immediately after less than 30 min of aerobic exercise. The improvements are greater for the incongruent than for the congruent color tests. This suggests that physical exercise induces a better performance in a task that requires resolving conflict (or interference than a task that does not. There is no significant improvement for the nonexercise control trials. This demonstrates that an increase in cardiovascular activity has significant acute effects on improving the executive function that requires conflict resolution (for the incongruent color tests immediately following aerobic exercise more than similar executive functions that do not require conflict resolution or involve the attention-inhibition process (for the congruent color tests.

  8. Apprehensive parents: a qualitative study on parents seeking immediate primary care for their children

    NARCIS (Netherlands)

    M. Hugenholtz; C. Bröer; R. van Daalen

    2009-01-01

    Background: Children are more frequent users of out-of-hours primary care than other age groups, although their medical problems are less urgent. Aim: To gain insight into the health-seeking behaviour of parents who ask for immediate medical attention for their children. Design of study: Qualitative

  9. 9 CFR 327.14 - Marking of products and labeling of immediate containers thereof for importation.

    Science.gov (United States)

    2010-01-01

    ... AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION IMPORTED PRODUCTS § 327.14... marks of inspection put on stencils, box dies, labels, and brands may be used on such immediate containers as tierces, barrels, drums, boxes, crates, and large-size fiberboard containers of foreign...

  10. Effect of Presentation Modality on Immediate and Delayed Recall in Individuals with Alzheimer's Disease

    Science.gov (United States)

    Mahendra, Nidhi; Bayles, Kathryn A.; Harris, Frances P.

    2005-01-01

    Episodic memory (EM) deficits are the hall-mark of Alzheimer's disease (AD). Story-retelling tasks are particularly sensitive to EM impairments and require participants to recall a short story immediately and after a delay. The purpose of this study was to determine whether presentation modality influences story recall in AD participants. Thirty…

  11. 78 FR 62921 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-10-22

    ... COMMISSION Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness... marketed by the Exchange by featuring and advertising them on the Exchange's Web site. Market-Q will be... comments on the proposed rule change. III. Date of Effectiveness of the Proposed Rule Change and Timing...

  12. 78 FR 28669 - Self-Regulatory Organizations; BATS Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-05-15

    ... exchanges and non-exchange markets. Further, excessive fees for connectivity, including logical port fees...'' section of its fee schedule effective immediately, in order to (i) increase fees for any logical port with bulk-quoting capabilities; and (ii) to eliminate the waiver of fees for logical ports with...

  13. 76 FR 22939 - Self-Regulatory Organizations; CBOE Futures Exchange, LLC; Notice of Filing and Immediate...

    Science.gov (United States)

    2011-04-25

    ... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; CBOE Futures Exchange, LLC; Notice of Filing and Immediate... Futures Correction In notice document 2011-7981 appearing on pages 18818-18821 in the issue of...

  14. 75 FR 48393 - Self-Regulatory Organizations; National Futures Association; Notice of Filing and Immediate...

    Science.gov (United States)

    2010-08-10

    ... COMMISSION Self-Regulatory Organizations; National Futures Association; Notice of Filing and Immediate... recommendations for certain customers for whom futures trading is too risky. \\6\\ 15 U.S.C. 78o-3(k)(2)(B). B. Self... ensure that customers have full and appropriate disclosures of the risks of futures trading. C....

  15. 75 FR 47666 - Self-Regulatory Organizations; National Futures Association; Notice of Filing and Immediate...

    Science.gov (United States)

    2010-08-06

    ... COMMISSION Self-Regulatory Organizations; National Futures Association; Notice of Filing and Immediate... Statement for Security Futures Contracts'' August 2, 2010. Pursuant to Section 19(b)(7) of the Securities..., 2010, National Futures Association (``NFA'') filed with the Securities and Exchange Commission...

  16. 75 FR 1431 - Self-Regulatory Organizations; National Futures Association; Notice of Filing and Immediate...

    Science.gov (United States)

    2010-01-11

    ... COMMISSION Self-Regulatory Organizations; National Futures Association; Notice of Filing and Immediate Effectiveness of a Proposed Change to the Interpretive Notice Regarding Security Futures Products Proficiency...\\ and Rule 19b-7 under the Act \\2\\ notice is hereby given that on December 11, 2009, National...

  17. 76 FR 3188 - Self-Regulatory Organizations; NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Science.gov (United States)

    2011-01-19

    ... COMMISSION Self-Regulatory Organizations; NASDAQ Stock Market LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Relating to Routing Fees for the NASDAQ Options Market January 12, 2011...,\\2\\ notice is hereby given that on January 6, 2011, The NASDAQ Stock Market LLC (``NASDAQ'' or...

  18. 76 FR 78325 - Self-Regulatory Organizations; NASDAQ Stock Market LLC; Notice of Filing and Immediate...

    Science.gov (United States)

    2011-12-16

    ... COMMISSION Self-Regulatory Organizations; NASDAQ Stock Market LLC; Notice of Filing and Immediate... hereby given that on November 30, 2011. The NASDAQ Stock Market LLC (``NASDAQ'' or ``Exchange'') filed... of the Proposed Rule Change The NASDAQ Stock Market LLC proposes to amend Rule 7056 entitled ``NASDAQ...

  19. Acute cortisol effects on immediate free recall and recognition of nouns depend on stimulus valence

    NARCIS (Netherlands)

    Tops, M.; van der Pompe, G.; Baas, D; Mulder, L.J.M.; Den Boer, J.A.; Meijman, T.F.; Korf, J

    The present study investigated the acute effects of cortisol administration in normal healthy male volunteers on immediate free recall and recognition of pleasant, unpleasant, and neutral nouns using a between-subjects double-blind design. Two hours after cortisol (10 mg) or placebo administration,

  20. Do testing effects change over time? Insights from immediate and delayed retrieval speed

    NARCIS (Netherlands)

    Broek, G.S.E. van den; Segers, P.C.J.; Takashima, A.; Verhoeven, L.T.W.

    2014-01-01

    Retrieving information from memory improves recall accuracy more than continued studying, but this testing effect often only becomes visible over time. In contrast, the present study documents testing effects on recall speed both immediately after practice and after a delay. A total of 40

  1. Examining the Relationship between Free Recall and Immediate Serial Recall: The Effect of Concurrent Task Performance

    Science.gov (United States)

    Bhatarah, Parveen; Ward, Geoff; Tan, Lydia

    2006-01-01

    In 3 experiments, participants saw lists of 16 words for free recall with or without a 6-digit immediate serial recall (ISR) task after each word. Free recall was performed under standard visual silent and spoken-aloud conditions (Experiment 1), overt rehearsal conditions (Experiment 2), and fixed rehearsal conditions (Experiment 3). The authors…

  2. Do testing effects change over time? Insights from immediate and delayed retrieval speed

    NARCIS (Netherlands)

    Broek, G.S.E. van den; Segers, P.C.J.; Takashima, A.; Verhoeven, L.T.W.

    2014-01-01

    Retrieving information from memory improves recall accuracy more than continued studying, but this testing effect often only becomes visible over time. In contrast, the present study documents testing effects on recall speed both immediately after practice and after a delay. A total of 40 participan

  3. Treatment-Continuity of ADHD Compared Using Immediate-Release and Extended-Release MPH

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2005-07-01

    Full Text Available The continuity of methylphenidate (MPH therapy for ADHD in young Medicaid beneficiaries (ages 6 to 17 years treated with immediate-release (IR or extended-release (ER MPH formulations was compared in an analysis of statewide California Medicaid claims (2000-2003 conducted at Columbia University, New York; University of Pennsylvania, Philadelphia; and McNeil Pharmaceuticals, Fort Washington, PA.

  4. The effect of immediate breast reconstruction on the timing of adjuvant chemotherapy: a systematic review

    NARCIS (Netherlands)

    J. Xavier Harmeling; C.A.E. Kouwenberg (Casimir A. E.); E. Bijlard (Eveline); K.N.J. Burger (Koert N. J.); A. Jager (Agnes); M.A.M. Mureau (Marc)

    2015-01-01

    textabstractAdjuvant chemotherapy is often needed to achieve adequate breast cancer control. The increasing popularity of immediate breast reconstruction (IBR) raises concerns that this procedure may delay the time to adjuvant chemotherapy (TTC), which may negatively impact oncological outcome. The

  5. Factors influencing the decision to pursue immediate breast reconstruction after mastectomy for breast cancer

    NARCIS (Netherlands)

    Weenk, M.; Wunschel, P.; Heine, E.; Strobbe, L.J.A.

    2017-01-01

    BACKGROUND: Immediate breast reconstruction (IBR) after mastectomy has shown to be oncologically safe and to improve quality of life in breast cancer patients. However, most women undergoing mastectomy do not undergo IBR. In this study, we aim to identify breast surgeon-related factors in

  6. Surfactant treatment before reperfusion improves the immediate function of lung transplants in rats

    NARCIS (Netherlands)

    Erasmus, ME; Petersen, AH; Hofstede, G; Haagsman, HP; Oetomo, SB; Prop, J

    1996-01-01

    An impaired function of alveolar surfactant can cause lung transplant dysfunction early after reperfusion. In this study it was investigated whether treatment with surfactant before reperfusion improves the immediate function of lung transplants and whether an improved transplant function was associ

  7. Neurotropic virus infections as the cause of immediate and delayed neuropathology

    NARCIS (Netherlands)

    M. Ludlow (Martin); J. Kortekaas, J. (Jeroen); C. Herden, C. (Christiane); B. Hoffmann (Bernd); D. Tappe, D. (Dennis); C. Trebst, C. (Corinna); D.E. Griffin, D.E. (Diane); H.E. Brindle, H.E. (Hannah); T. Solomon, T. (Tom); A.S. Brown (Alan S.); D.A.J. van Riel (Debby); K.C. Wolthers (Katja); D. Pajkrt (Dasja); P. Wohlsein (Peter); B.E.E. Martina (Byron); W. Baumgärtner (Wolfgang); G.M.G.M. Verjans (George); A.D.M.E. Osterhaus (Albert)

    2015-01-01

    textabstractA wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibl

  8. Neurotropic virus infections as the cause of immediate and delayed neuropathology

    NARCIS (Netherlands)

    M. Ludlow (Martin); J. Kortekaas (Jeroen); C. Herden (Christiane); B. Hoffmann (Bernd); D. Tappe (Dennis); C. Trebst (Corinna); D.E. Griffin (Diane E.); H.E. Brindle (Hannah E.); T. Solomon (Tom); A.S. Brown (Alan S.); D.A.J. van Riel (Debby); K.C. Wolthers (Katja); D. Pajkrt (Dasja); P. Wohlsein (Peter); B.E.E. Martina (Byron); W. Baumgärtner (Wolfgang); G.M. Verjans (Georges M.); A.D.M.E. Osterhaus (Albert)

    2016-01-01

    textabstractA wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibl

  9. Neurotropic virus infections as the cause of immediate and delayed neuropathology

    NARCIS (Netherlands)

    Ludlow, Martin; Kortekaas, Jeroen; Herden, Christiane; Hoffmann, Bernd; Tappe, Dennis; Trebst, Corinna; Griffin, Diane E.; Brindle, Hannah E.; Solomon, Tom; Brown, Alan S.; Riel, van Debby; Wolthers, Katja C.; Pajkrt, Dasja; Wohlsein, Peter; Martina, Byron E.E.; Baumgärtner, Wolfgang; Verjans, Georges M.; Osterhaus, Albert D.M.E.

    2016-01-01

    A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt

  10. A feasibility study of immediate versus deferred antiretroviral therapy in children with HIV infection

    Directory of Open Access Journals (Sweden)

    Ubolyam Sasiwimol

    2008-10-01

    Full Text Available Abstract Objective To evaluate the feasibility of a large immediate versus deferred antiretroviral therapy (ART study in children. Methods We conducted an open-label pilot randomized clinical trial study in 43 Thai children with CD4 15 to 24% of starting generic AZT/3TC/NVP immediately (Arm 1 or deferring until CD4 Results Recruitment took 15 months. Twenty-six of 69 (37.7% were not eligible due mainly to low CD4%. Twenty four and 19 were randomized to arms 1 and 2 respectively. All accepted the randomized arm; however, 3 in arm 1 stopped ART and 1 in arm 2 refused to start ART. Ten/19 (53% in arm 2 started ART. At baseline, median age was 4.8 yrs, CDC A:B were 36:7, median CD4 was 19% and viral load was 4.8 log. All in arm 1 and 17/19 in arm 2 completed the study (median of 134 weeks. No one had AIDS or death. Four in immediate arm had tuberculosis. Once started on ART, deferred arm children achieved similar CD4 and viral load response as the immediate arm. Adverse events were similar between arms. The deferred arm had a 26% ART saving. Conclusion Almost 40% of children were not eligible due mainly to low CD4% but adherence to randomized treatment and retention in trial were excellent. A larger study to evaluate when to start ART is feasible.

  11. Immediate and delayed cochlear neuropathy after noise exposure in pubescent mice

    DEFF Research Database (Denmark)

    Jensen, Jane Bjerg; Lysaght, Andrew C; Liberman, M Charles

    2015-01-01

    to 16 months post exposure. Mice exposed to neuropathic noise demonstrated immediate cochlear synaptopathy by 24 hours post exposure, and delayed neurodegeneration characterized by axonal retraction at 8 months, and spiral ganglion cell loss at 8-16 months post exposure. Although the damage...

  12. Exploring Effectiveness of Computer-Aided Planning in Implant Positioning for a Single Immediate Implant Placement.

    Science.gov (United States)

    Edelmann, Alexander R; Hosseini, Bashir; Byrd, Warren C; Preisser, John S; Tyndall, Donald A; Nguyen, Tung; Bencharit, Sompop

    2016-06-01

    The value of computer-aided implant planning using cone-beam computerized tomography (CBCT) for single immediate implants was explored. Eighteen patients requiring extraction of a tooth followed by a single immediate implant were enrolled. Small volume preoperative CBCT scans were used to plan the position of the implant. A taper screwed-type implant was immediately placed into a fresh socket using only the final 1 or 2 drills for osteotomy. Postoperative CBCTs were used for the analysis of actual implant placement positioning. Measurements of the planned and the actual implant position were made with respect to their position relative to the adjacent teeth. Mesio-distal displacements and the facial-lingual deviation of the implant from the planned position were determined. Changes in the angulation of the planned and actual implant position in relation to the clinical crown were also measured. To statistically summarize the results, box plots and 95% CIs for means of paired differences were used. The analysis showed no statistical difference between the planned position and final implant placement position in any measurement. The CBCT scans coupled with the computer-aided implant planning program along with a final 1-to-2 drill protocol may improve the accuracy of single immediate implant placement for taper screwed-type implants.

  13. Risk factors for immediate post-operative fatal recurrence after curative resection of hepatocellular carcinoma

    OpenAIRE

    Kim, Bong-Wan; Kim, Young-Bae; Wang, Hee-Jung; Kim, Myung-Wook

    2006-01-01

    AIM: To investigate the clinicopathological risk factors for immediate post-operative fatal recurrence of hepatocellular carcinoma (HCC), which may have practical implication and contribute to establishing high risk patients for pre- or post-operative preventive measures against HCC recurrence.

  14. Timing matters: The impact of immediate and delayed feedback on artificial language learning

    Directory of Open Access Journals (Sweden)

    Bertram Opitz

    2011-02-01

    Full Text Available In the present experiment, we used event-related potentials (ERP to investigate the role of immediate and delayed feedback in an artificial grammar learning task. Two groups of participants were engaged in classifying non-word strings according to an underlying rule system, not known to the participants. Visual feedback was provided after each classification either immediately or with a short delay of one second. Both groups were able to learn the artificial grammar system as indicated by an increase in classification performance. However, the gain in performance was significantly larger for the group receiving immediate feedback as compared to the group receiving delayed feedback. Learning was accompanied by an increase in P300 activity in the ERP for delayed as compared to immediate feedback. Irrespective of feedback delay, both groups exhibited learning related decreases in the feedback-related positivity (FRP elicited by positive feedback only. The feedback-related negativity (FRN, however, remained constant over the course of learning. These results suggest, first, that delayed feedback is less effective for artificial grammar learning as task requirements are very demanding, and second, that the FRP elicited by positive prediction errors decreases with learning while the FRN to negative prediction errors is elicited in an all-or-none fashion by negative feedback throughout the entire experiment.

  15. Eat now, exercise later: The relation between consideration of immediate and future consequences and healthy behavior

    NARCIS (Netherlands)

    Beek, van J.; Antonides, G.; Handgraaf, M.J.J.

    2013-01-01

    In light of the current obesity epidemic, individual choices for food and exercise should be understood better. Consideration of the immediate and future consequences of these choices (i.e., time orientation) can be an important predictor of eating and exercising behavior. The objective was to show

  16. Immediate versus deferred coronary angioplasty in non-ST-segment elevation acute coronary syndromes

    NARCIS (Netherlands)

    Riezebos, R.K.; Ronner, E.; ter Bals, E.; Slagboom, T.; Smits, P.C.; ten Berg, J.M.; Kiemeneij, F.; Amoroso, G.; Patterson, M.S.; Suttorp, M.J.; Tijssen, J.G.P.; Laarman, G.J.

    2009-01-01

    BACKGROUND: The field of acute coronary syndromes is characterised by an increasing tendency towards early invasive catheter-based diagnostics and therapeutics-a practice based on observational and retrospective data. OBJECTIVE: To compare immediate versus deferred angioplasty in patients with non-S

  17. 78 FR 78447 - Self-Regulatory Organizations; Topaz Exchange, LLC; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2013-12-26

    ..., the Exchange proposes to revise the relevant language in its Schedule of Fees to state that Priority... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; Topaz Exchange, LLC; Notice of Filing and Immediate...

  18. 76 FR 74092 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2011-11-30

    ... filing, the Exchange proposes to amend the language of two routing options contained in Rule 11.9(b)(3... From the Federal Register Online via the Government Publishing Office ] SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate...

  19. 76 FR 74090 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2011-11-30

    ... filing, the Exchange proposes to amend the language of two routing options contained in Rule 11.9(b)(3... From the Federal Register Online via the Government Publishing Office SECURITIES AND EXCHANGE COMMISSION Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate...

  20. Persistent pain, sensory disturbances and functional impairment after immediate or delayed axillary lymph node dissection

    DEFF Research Database (Denmark)

    Geving Andersen, Kenneth; Jensen, Maj-Britt Raaby; Tvedskov, Tove Filtenborg

    2013-01-01

    BACKGROUND: Patients treated with 2-step axillary lymph node dissection (ALND) may be at increased risk of nerve damage due to more challenging surgery than an ALND immediately after a sentinel lymph node biopsy (SLNB), and thus more at risk for persistent pain after breast cancer treatment (PPBCT...

  1. Theorising the Relationship between Older People and Their Immediate Social Living Environment

    Science.gov (United States)

    Buffel, Tine; Verte, Dominique; De Donder, Liesbeth; De Witte, Nico; Dury, Sarah; Vanwing, Tom; Bolsenbroek, Anouk

    2012-01-01

    This article presents a theoretical framework for exploring the dynamics between older people and their immediate social living environment. After introducing a gerontological perspective that goes beyond "microfication," a literature review presents findings from studies that have explored the role of place and locality for older people. Next,…

  2. Immediate effect of valgus bracing on knee joint moments in meniscectomised patients

    DEFF Research Database (Denmark)

    Thorning, Maria; Thorlund, Jonas Bloch; Roos, Ewa M

    2016-01-01

    OBJECTIVES: Patients undergoing medial arthroscopic partial meniscectomy are at increased risk of developing and/or progressing knee osteoarthritis, with increased medial compartment load being a potential contributor. The aim of this study was to evaluate the immediate effect of a valgus unloade...... tasks. Future research is required to explore the structural implications....

  3. 75 FR 33358 - Duke Energy Carolinas, LLC; McGuire Nuclear Station; Confirmatory Order (Effective Immediately)

    Science.gov (United States)

    2010-06-11

    ... Carolinas, LLC; McGuire Nuclear Station; Confirmatory Order (Effective Immediately) I Duke Energy Carolinas, LLC's (Duke Energy or Licensee) is the holder of License Nos. NPF-9 and NPF-17, issued by the Nuclear... Energy Nuclear Policy Manual, NSD 218.10.1, Revision 9, states in relevant part, that where unusual...

  4. Does the exposure to smoking cues in movies affect adolescents' immediate smoking behavior?

    NARCIS (Netherlands)

    Lochbühler, K.C.; Kleinjan, M.; Engels, R.C.M.E.

    2013-01-01

    Introduction Various studies have demonstrated that environmental smoking cues elicit smoking-related responses in smokers. However, cue reactivity studies among adolescent smokers are scarce. Therefore, the aim of this study was to examine the effect of smoking portrayal in movies on immediate smok

  5. Immediate implant loading with fixed dental restorations: An animal model study

    Directory of Open Access Journals (Sweden)

    Špadijer-Gostović Aleksandra

    2012-01-01

    Full Text Available Background/Aim. Immediate loading is considered to be the most innovative technique in contemporary implant dentistry. Recent clinical and experimental findings have demonstrated that only implants with high primary stability can be subjected to immediate loading protocol with predictable results. It is generally accepted that the most important prerequsite for successful osseointegration is achievement and maintenance of implant stability. The aim of this in vivo study was to investigate the possibility for successful application of immediate loading protocol in implant systems with different surface properties. Methods. In the experimental study 2 mongrel dogs were edentulated bilaterally in the mandibular and maxillary premolar areas. After 3 months implants were placed in a pattern 4 different commercially available implants per quadrant (n = 32: Mk III TiUnite (Nobel Biocare, Sweden, ITI TPS (Straumann, Switzerland, 3IOsseotite (Implant Innovation, USA and XiVE Cell-Plus (Friadent, Germany. Implants were subjected to immediate loading with 4 unit gold cast bridges, 2 days post implantation. The assessment of implant stability and immediate loading possibilities were done by performing Resonance frequency analysis (RFA. Results. After a 6- month loading period all bridges were in function and all implants occurred well osseointegrated. When summarizing the Implant Stability Quotient (ISQ values, it was noted that resonance frequency was significantly higher for mandibular implants. The results of this experimental setting showed that all evaluated surfaces achieved good implant stability. Increase of ISQ values was found for all implants in the mandible and partially decrease of ISQ values for maxillary implants after 6 months of functional loading with 4 unit bridges. Conclusions. Investigated endooseal implants did not show different degree of osseointegration, because there was not statisticaly significant difference among observed

  6. Buccal bone loss after immediate implantation can be reduced by the flapless approach

    Directory of Open Access Journals (Sweden)

    ARTHUR BELÉM NOVAES JR

    2011-10-01

    Full Text Available Aim: The aim of this study was to evaluate the buccal bone remodeling after immediate implantation with flap or flapless approach. Material and Methods: The mandibular bilateral premolars of 3 dogs were extracted and immediately three implants were placed in both hemi-arches of each dog. Randomly, one hemi-arch was treated with the flapless approach, while in the contra lateral hemi-arch tooth extractions and implant placement were done after mucoperiosteal flap elevation. Non-submerged healing of 12 weeks was provided for both groups. Histomorphometric analysis was done to compare buccal and lingual bone height loss, bone density and bone-to-implant contact in the groups. Fluorescence analysis was performed to investigate the dynamic of bone remodeling in the different groups. Results: There was a significant association between the surgical flap and the extent of bone resorption around immediate implants. The loss of buccal bone height was significantly lower in the flapless group when compared to the flap group (0.98 mm x 2.14 mm, respectively, p<0.05. The coronal and apical buccal bone densities of the flap group were significantly higher when compared to the lingual components, showing anatomical differences between the bone plates. Fluorescence analysis showed no major differences in bone healing between the flap and flapless groups, supporting that the higher loss of buccal bone height is linked to the anatomic characteristics of this plate and to the negative influence of the detachment of the periosteum in immediate implant therapy. Conclusion: The flapless approach for immediate post-extraction implants reduces the buccal bone height loss.

  7. Immediate postmastectomy breast reconstruction showed limited advantage in patient survival after stratifying by family income.

    Directory of Open Access Journals (Sweden)

    Yi-Zhou Jiang

    Full Text Available BACKGROUND: Postmastectomy breast reconstruction is widely used in breast cancer patients for its aesthetic effect. Although several studies have casted suspicion upon the oncological safety of immediate breast reconstruction after mastectomy, the potential impact of different reconstruction methods on patient survival remains unclear. PATIENTS AND METHODS: We identified 35,126 female patients diagnosed with breast cancer from January 1, 1998 to December 31, 2002 in the Surveillance, Epidemiology, and End Results database. Breast cancer-specific survival (BCSS and overall survival (OS were compared among patients who underwent mastectomy with or without immediate breast reconstruction (autologous reconstruction or implant reconstruction using Cox proportional hazard regression models. RESULTS: In multivariate analysis unadjusted for family income, patients undergoing immediate postmastectomy reconstruction exhibited improved BCSS [POOLED reconstruction (any types of reconstruction: hazard ratio (HR  =  0.87, 95% confidence interval (CI 0.80-0.95, P = 0.001] and OS (pooled reconstruction: HR = 0.70, 95% CI 0.65-0.75, P<0.001 compared to patients who underwent mastectomy alone. However, after stratifying by family income, patients receiving reconstruction showed limited advantage in BCSS and OS compared with those undergoing mastectomy alone. When comparing between the two reconstruction methods, no significant differences were observed in either BCSS (implant versus autologous reconstruction: HR = 1.11, 95%CI 0.90-1.35, P = 0.330 or OS (implant versus autologous reconstruction: HR = 1.07, 95% 0.90-1.28, P = 0.424. CONCLUSIONS: Compared to mastectomy alone, immediate postmastectomy reconstruction had limited advantage in survival after adjusting for confounding factor of family income. Our findings, if validated in other large databases, may help to illustrate the actual effect of immediate postmastectomy reconstruction on patient survival.

  8. Histologic and histomorphometric behavior of microgrooved zirconia dental implants with immediate loading.

    Science.gov (United States)

    Delgado-Ruiz, Rafael Arcesio; Calvo-Guirado, Jose Luis; Abboud, Marcus; Ramirez-Fernandez, Maria Piedad; Maté-Sánchez de Val, José Eduardo; Mate-Sanchez, Jose Eduardo; Negri, Bruno; Rothamel, Daniel

    2014-12-01

    The study aims to assess the total soft tissue (ST) width, crestal bone level (CBL), bone-to-implant contact (BIC), and bone density (BD) for zirconia implants textured with microgrooved surfaces and immediately loaded. This study included 51 implants; one implant from each study group was retained for surface characterization. The 48 remaining implants were inserted randomly in premolar areas of both sides of the healed edentulous lower jaws of foxhound dogs. They were divided into three groups of 16: control (titanium); test A (zirconia), and test B (microgrooved zirconia). The implants were splinted and covered with an acrylic bridge. A split-mouth design was used and immediate occlusal loading was applied on one side, while the other side did not have occlusal contact. ST, CBL, BIC, and BD were evaluated after 3 months. The effects of immediate loading on these parameters were analyzed. All the implants were osseointegrated. ST was established at 3 months with mean values of 2.9 ± 0.4 mm for all groups. No differences were appreciated between loaded and unloaded sides regarding ST (p > .05). CBL showed a mean of 1.2 ± 0.3 mm for all groups without differences between loaded and unloaded sides (p > .05). BIC percentages were significantly higher for loaded all-microgrooved implants (p implants (p implants than unloaded. Within the limitations of the present study, it may be concluded that for zirconia dental implants with microgrooved surfaces and immediate loading, the thickness of STs remains stable resulting in 3 mm mean biologic width, that crestal bone preservation is related to insertion depth, and that higher BIC percentages and increased BD around implants microgrooved over the entire intraosseous area may be expected at 3 months following implant insertion and immediate loading. © 2013 Wiley Periodicals, Inc.

  9. Immediate vs Gradual Discontinuation in Antipsychotic Switching: A Systematic Review and Meta-analysis.

    Science.gov (United States)

    Takeuchi, Hiroyoshi; Kantor, Navot; Uchida, Hiroyuki; Suzuki, Takefumi; Remington, Gary

    2017-01-01

    Antipsychotic switching is routine in clinical practice, although it remains unclear which is the preferable switching method: immediate discontinuation of the current antipsychotic or a gradual tapering approach. The first strategy has been implicated in rebound/withdrawal symptoms and emergence/exacerbation of symptoms, whereas the gradual approach is thought to pose a risk of additive or synergistic side effects if employed in the context of a crossover approach. MEDLINE, Embase, and Cochrane Central Register of Controlled Trials were systematically searched. Randomized controlled trials examining immediate vs gradual antipsychotic discontinuation in antipsychotic switching in patients with schizophrenia and/or schizoaffective disorder were selected. Data on clinical outcomes, including study discontinuation, psychopathology, extrapyramidal symptoms, and treatment-emergent adverse events, were extracted. A total of 9 studies involving 1416 patients that met eligibility criteria were included in the meta-analysis. No significant differences in any clinical outcomes were found between the 2 approaches (all Ps > .05). Sensitivity analyses revealed that the findings remained unchanged in the studies where switching to aripiprazole was performed or where immediate initiation of the next antipsychotic was adopted, while some significant differences were observed in switching to olanzapine or ziprasidone. These findings indicate that either immediate or gradual discontinuation of the current antipsychotic medication represents a viable treatment option. Clinicians are advised to choose an antipsychotic switching strategy according to individual patient needs. This said, immediate discontinuation may be advantageous both for simplicity and because a stalled cross-titration process in antipsychotic switching could end up in antipsychotic polypharmacy. © The Author 2017. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All

  10. Analysis of immediate transfusion incidents reported in a regional blood bank

    Directory of Open Access Journals (Sweden)

    Adriana Lemos de Sousa Neto

    2011-10-01

    Full Text Available BACKGROUND: Blood transfusion is imperative when treating certain patients; however, it is not risk free. In addition to the possible transmission of contagious infectious diseases, incidents can occur immediately after transfusion and at a later time. AIMS: This study aimed to examine the immediate transfusion incidents reported in a regional blood bank in the state of Minas Gerais between December 2006 and December 2009. A retrospective quantitative epidemiological study was conducted. Data were obtained from 202 transfusion incident reports of 42 health institutions served by the blood bank. Data processing and analysis were carried out using the Statistical Package for the Social Sciences (SPSS software. RESULTS: The rate of immediate transfusion incidents reported in the period was 0.24%; febrile non-hemolytic reactions were the most common type of incident (56.4%. The most frequent clinical manifestations listed in transfusion incident reports were chills (26.9% and fever (21.6%. There was a statistically significant association (p-value < 0.05 between the infusion of platelet concentrates and febrile non-hemolytic reactions and between fresh frozen plasma and febrile non-hemolytic reaction. The majority (73.3% of transfused patients who suffered immediate transfusion incidents had already been transfused and 36.5% of the cases had previous transfusion incident reports. CONCLUSIONS: Data from the present study corroborate the implementation of new professional training programs aimed at blood transfusion surveillance. These measures should emphasize prevention, identification and reporting of immediate transfusion incidents aiming to increase blood transfusion quality and safety.

  11. Immediate loading with fixed full-arch prostheses in the maxilla: review of the literature.

    Science.gov (United States)

    Peñarrocha-Oltra, David; Covani, Ugo; Peñarrocha-Diago, Miguel; Peñarrocha-Diago, Maria

    2014-09-01

    To critically review the evidence-based literature on immediate loading of implants with fixed full-arch prostheses in the maxilla to determine 1) currently recommended performance criteria and 2) the outcomes that can be expected with this procedure. Studies from 2001 to 2011 on immediate loading with fixed full-arch maxillary prostheses were reviewed. Clinical series with at least 5 patients and 12 months of follow-up were included. Case reports, studies with missing data and repeatedly published studies were excluded. In each study the following was assessed: type of study, implant type, number of patients, number of implants, number of implants per patient, use of post-extraction implants, minimum implant length and diameter, type of prosthesis, time until loading, implant survival rate, prosthesis survival rate, marginal bone loss, complications and mean follow-up time. Criteria for patient selection, implant primary stability and bone regeneration were also studied. Thirteen studies were included, reporting a total of 2484 immediately loaded implants in 365 patients. Currently accepted performance criteria regarding patient and implant selection, and surgical and prosthetic procedures were deduced from the reviewed articles. Implant survival rates went from 87.5% to 100%, prosthesis survival rates from 93.8% to 100% and radiographic marginal bone loss from 0.8 mm to 1.6 mm.No intraoperative complications and only minor prosthetic complications were reported. The literature on immediate loading with fixed full-arch prostheses in the maxilla shows that a successful outcome can be expected if adequate criteria are used to evaluate the patient, choose the implant and perform the surgical and prosthetic treatment. Lack of homogeneity within studies limits the relevance of the conclusions that can be drawn, and more controlled randomized studies are necessary to enable comparison between the immediate and the conventional loading procedures.

  12. Complications of Radiotherapy after Immediate Breast Reconstruction with Implant: Risk Factors and Management - Our Institute’s Experience

    National Research Council Canada - National Science Library

    Heba G. El-Sheredy; Rabie Ramadan; Yasser Hamed

    2016-01-01

    .... This study aims to evaluate the complications of radiotherapy after immediate breast reconstruction with implants in breast cancer patients who submitted to skin sparing mastectomy and nipple sparing...

  13. Use of echosonography to monitor uterine placement of intrauterine devices after immediate postpartum insertions.

    Science.gov (United States)

    Ortiz Mariscal, J D; Guerrero Barrera, C; Wheeler, R G; Waszak, C S

    1987-02-01

    A study designed to monitor uterine placement of IUDs inserted immediately postpartum using echosonography was conducted at the Hospital de Gineco Obstetricia No. 23, "Dr. Ignacio Morones Prieto" in Monterrey, Mexico. TCu220 and Delta T IUDs were randomly assigned to, and inserted in women immediately following a normal vaginal delivery. Ultrasound examinations were to be performed within 60 min postinsertion, at 24 h postinsertion and at 1- and 3-month follow-up visits. There were no differences in the expulsion rates of the two device groups. Data are presented on the readings taken at the ultrasound examinations of the distance between the fundus and the upper part of the stem of the T. These differences differed significantly between the two device groups at the first ultrasound reading only (P less than or equal to 0.01). No relationship was found between the incidence of expulsion and the distance between the IUD and the fundus at any of the readings.

  14. Associative relatedness enhances recall and produces false memories in immediate serial recall.

    Science.gov (United States)

    Tehan, Gerald

    2010-12-01

    The influence of permanent lexical network in immediate serial recall is well established. The corresponding influence of permanent semantic networks is less clear, although such networks are known to both facilitate memory in long-term memory tasks and to produce false memories in those same tasks. The current experiment involves the study of Deese-Roediger-McDermott (DRM) lists for immediate serial recall. The trials in the experiment involved presenting the six strongest items from the DRM lists either in intact associatively related lists or where those items had been randomly mixed to produce unrelated lists. The results of the experiment indicated that the associatively related lists were better recalled in order than unrelated lists and the nonpresented critical lure was falsely recalled relatively frequently. The results of the experiment confirm the importance of associative semantic networks in short-term memory.

  15. Crustacean peptidergic neurons in culture show immediate outgrowth in simple medium.

    Science.gov (United States)

    Cooke, I; Graf, R; Grau, S; Haylett, B; Meyers, D; Ruben, P

    1989-01-01

    The survival and outgrowth of neurons in culture has usually required conditioning factors. We now report that crustacean neurons, taken from the peptidergic neurosecretory system of the eyestalk of crabs (Cardisoma carnifex) and lobsters (Panulirus marginatus), show immediate outgrowth, sustained for a week or more, in defined medium as simple as physiological saline with glucose and glutamine. The neurons show peptide hormone immunoreactivity that is prominent at growth cones, exhibit differences in form correlated with their immunoreactivity, release peptides to the medium, and have voltage-dependent currents, including a well-sustained Ca current. Cd blocks secretion, growth, and the Ca current. Peptidergic secretory neurons may be able to utilize existing membrane from their store of granules and already active synthetic, transport, and secretory mechanisms for immediate outgrowth.

  16. Immediate acoustic effects of straw phonation exercises in subjects with dysphonic voices.

    Science.gov (United States)

    Guzman, Marco; Higueras, Diego; Fincheira, Catherine; Muñoz, Daniel; Guajardo, Carlos; Dowdall, Jayme

    2013-04-01

    Abstract This study sought to measure any acoustic changes in the speaking voice immediately after phonation exercises involving plastic straws versus phonation exercises with the open vowel /a/. Forty-one primary school teachers with slightly dysphonic voices were asked to participate in four phonatory tasks. Phonetically balanced text at habitual intensity level and speaking fundamental frequency was recorded. Acoustical analysis with long-term average spectrum was performed. Significant changes after therapy for the experimental group include the alpha ratio, L1-L0 ratio and ratio between 1-5 kHz and 5-8 kHz. The results indicate that the use of phonatory tasks with straw exercises can have immediate therapeutic acoustic effects in dysphonic voices. Long-term effects were not assessed in this study.

  17. Immediate provisional restoration of a single-tooth implant in the esthetic zone: A case report

    Directory of Open Access Journals (Sweden)

    Po-Sung Fu

    2011-02-01

    Full Text Available Immediate implant restoration of single implants may demonstrate a positive effect on peri-implant soft tissue. Placement of a provisional restoration following implant surgery can create soft tissue contours that resemble normal gingival topography before placement of the definitive prosthesis. This article describes a staged approach of the mandibular permanent right central incisor, which was congenital missing. The proper space for restoration of the missing incisor was created through orthodontic treatment. The scheduled implant site was reconstructed using autogenous bone harvested from the chin region. After a healing period of four months, an implant was installed with the connection of a fixed provisional crown to a prefabricated temporary abutment. The soft tissue around the implant healed according to the contours of the provisional restoration and the emergence profile was used to duplicate the definitive restoration. Peri-implant esthetics was achieved through the staged approach and immediate restoration of the implant.

  18. Progressive immediate loading of a perforated maxillary sinus dental implant: a case report.

    Science.gov (United States)

    Al-Juboori, Mohammed Jasim

    2015-01-01

    The displacement of a dental implant into the maxillary sinus may lead to implant failure due to exposure of the apical third or the tip of the implant beyond the bone, resulting in soft tissue growth. This case report discusses dental implant placement in the upper first molar area with maxillary sinus involvement of approximately 2 mm. A new technique for progressive implant loading was used, involving immediately loaded implants with maxillary sinus perforation and low primary stability. Follow-up was performed with resonance frequency analysis and compared with an implant placed adjacent in the upper second premolar area using a conventional delayed loading protocol. Implants with maxillary sinus involvement showed increasing stability during the healing period. We found that progressive implant loading may be a safe technique for the placement of immediately loaded implants with maxillary sinus involvement.

  19. Immediate improvement of motor function after epilepsy surgery in congenital hemiparesis.

    Science.gov (United States)

    Pascoal, Tharick; Paglioli, Eliseu; Palmini, André; Menezes, Rafael; Staudt, Martin

    2013-08-01

    Hemispherectomy often leads to a loss of contralateral hand function. In some children with congenital hemiparesis, however, paretic hand function remains unchanged. An immediate improvement of hand function has never been reported. A 17-year-old boy with congenital hemiparesis and therapy-refractory seizures due to a large infarction in the territory of the middle cerebral artery underwent epilepsy surgery. Intraoperatively, electrical cortical stimulation of the affected hemisphere demonstrated preserved motor projections from the sensorimotor cortex to the (contralateral) paretic hand. A frontoparietal resection was performed, which included a complete disconnection of all motor projections originating in the sensorimotor cortex of the affected hemisphere. Surprisingly, the paretic hand showed a significant functional improvement immediately after the operation. This observation demonstrates that, in congenital hemiparesis, crossed motor projections from the affected hemisphere are not always beneficial, but can be dysfunctional, interfering with ipsilateral motor control over the paretic hand by the contralesional hemisphere. Wiley Periodicals, Inc. © 2013 International League Against Epilepsy.

  20. [Video-assisted extirpation of breast fibroadenoma with immediate bilateral breast augmentation--a case report].

    Science.gov (United States)

    Gverić, Tugomir; Semanjski, Kristina; Barić, Marko; Adanić, Zrnka; Pintar, Miljana; Zdilar, Boris; Huljev, Dubravko; Krstonijević, Zoran; Gorski, Dinko; Gverić-Ahmetasević, Snjezana

    2011-01-01

    Since mid 1990s video-assisted breast surgery (VABS) has been developed in the treatment of benign and malignant breast diseases. According to studies that are conducted mainly in Japan, this tehnique is safe, easy to learn and his main advantage is excellent cosmetic results on postoperative appearance of breasts that cannot be achived with standard surgical procedures. To present a first case of video assisted breast surgery in Croatia applied to treatment of breast fibroadenoma and immediate bilateral breast augmentation. A 39 year old female patient was admitted to our hospital for elective procedure of breast augmentation. On this occasion video assisted extirpation of fibroadenoma was performed through inframammary incision and followed by immediate bilateral breast augmentation. VABS is feasible, cosmetic effects are evident and the VABS deserves attention as a possible surgical option in breast surgery. However further experience on this field must be gained and it remains to evaluate this tehnique on the additional studies.

  1. Immediate Dental Implant Placements Using Osteotome Technique: A Case Report and Literature Review.

    Science.gov (United States)

    Al-Almaie, Saad

    2016-01-01

    This clinical case describes the effect of the osteotome technique on the osseointegration of a mandibular dental implant in a 42-year-old female patient with dento-alveolar bony defects and to review the literature regarding immediate implant placement using osteotome technique. The amount of bone expansion at the alveolar ridge and the marginal bone resorption from the time of implant placement to one year after the implant's functional loading were recorded clinically. The esthetic outcome for the restored implant (the gingival margin) was achieved one years after the implant's functional loading. The surgical and prosthetic sites for the implant showed no postoperative complications, and no infection or wound dehiscence was recorded during the follow-up period. The osteotome technique is good for the purpose for which it was introduced, and its advantages with immediate implant placement include reduced surgical trauma and a shorter treatment time.

  2. DETECTION OF CYTOMEGALOVIRUS(CMV) IMMEDIATE EARLY ANTIGEN IN KIDNEY BIOPSIES AND TRANSPLANT NEPHRECTOMIES

    Institute of Scientific and Technical Information of China (English)

    燕航; 薛武军; 田普训; 郭奇; 何晓丽

    2004-01-01

    Objective To investigate the relationship between CMV infection and renal allograft rejection. Methods 39 kidney biopsies and transplant nephrectomies were collected and investigated for CMV immediate early antigen by immunohistochemistry. Results In 14 out of 39 tissue specimens CMV immediate early antigen were found. 8 biopsies from normal donor kidneys were negative; only 1 (10%) in 10 tissue specimens with early stage acute rejection was positive; 5(55.6%) in 9 biopsies with late stage acute rejection and 8 (66.7%) in 12 tissue blocks with chronic rejection were positive. Compared with normal kidney tissues, the infections in tissues with early stage acute rejection didn't increase obviously, but increased obviously in kidney tissue specimens with late stage rejection and with chronic rejection (P<0.05). Conclusion CMV infection appears to contribute to late stage acute rejection and chronic rejection after renal transplantation.

  3. Immediate provisional restoration of implant placed using flapless surgery and ridge mapping. Case report.

    Science.gov (United States)

    Turkyilmaz, Ilser

    2011-04-01

    Loss of an anterior tooth as the result of trauma is relatively common, especially in the young. Orthodontic treatment is not always the definitive therapy of choice; instead, an implant can be placed to replace the missing tooth. This article describes the case of a 19-year-old woman whose maxillary left central incisor was replaced by an immediately restored dental implant, placed using flapless surgery. The implant achieved excellent primary stability, as determined by resonance frequency analysis, so it was immediately restored with a provisional acrylic resin crown in no centric occlusion. This case report supports the use of single implants for replacing a missing anterior tooth where esthetics are a priority.

  4. Immediate transient thrombocytopenia at the time of alemtuzumab infusion in multiple sclerosis.

    Science.gov (United States)

    Ranganathan, Usha; Kaunzner, Ulrike; Foster, Stacyann; Vartanian, Timothy; Perumal, Jai S

    2017-03-01

    Alemtuzumab is a monoclonal antibody approved for relapsing-remitting multiple sclerosis (RRMS). Although Immune thrombocytopenia (ITP) has been reported as a secondary autoimmune phenomenon following alemtuzumab infusion, immediate thrombocytopenia during the infusion has not been reported. We report transient, reversible, self-limiting acute-onset thrombocytopenia during the first course with alemtuzumab. In total, 3 of 22 paitents developed mild self-limited bruising associated with a drop in platelet count from their baseline during the intial 5-day course of alemtuzumab. Upon chart review, all 22 patients who received alemtuzumab developed an immediate mostly asymptomatic drop in platelet count which returned to normal within 2 months post-infusion.

  5. How factors present during the immediate interrogation situation produce short-sighted confession decisions.

    Science.gov (United States)

    Madon, Stephanie; Yang, Yueran; Smalarz, Laura; Guyll, Max; Scherr, Kyle C

    2013-02-01

    Suspects have a preexisting vulnerability to make short-sighted confession decisions, giving disproportionate weight to proximal, rather than distal, consequences. The findings of the current research provided evidence that this preexisting vulnerability is exacerbated by factors that are associated with the immediate interrogation situation. In Experiment 1 (N = 118), a lengthy interview exacerbated participants' tendency to temporally discount a distal consequence when deciding whether or not to admit to criminal and unethical behaviors. This effect was especially pronounced among less serious behaviors. In Experiment 2 (N = 177), participants' tendency to temporally discount a distal consequence when making admission decisions was exacerbated by the expectation of a lengthy interview; an effect that became stronger the longer the interview continued. These findings suggest that conditions of the immediate interrogation situation may capitalize on an already-present vulnerability among suspects to make short-sighted confession decisions, thereby increasing the chances that even innocent suspects might confess.

  6. Effect of disodium cromoglycate on mast cell-mediated immediate-type allergic reactions.

    Science.gov (United States)

    Shin, Hye-Young; Kim, Jung-Sook; An, Nyeon-Hyoung; Park, Rae-Kil; Kim, Hyung-Min

    2004-04-23

    We investigated the effect of disodium cromoglycate (DSCG) on mast cell-mediated immediate-type hypersensitivity. DSCG inhibited systemic allergic reaction induced by compound 48/80 dose-dependently. Passive cutaneous anaphylaxis was inhibited by 71.6% by oral administration of DSCG (1 g/kg). When DSCG was pretreated at concentration rang from 0.01-1000 g/kg, the serum histamine levels were reduced in a dose dependent manner. DSCG also significantly inhibited histamine release from rat peritoneal mast cell (RPMC) by compound 48/80. We confirmed that DSCG inhibited compound 48/80-induced degranulation of RPMC by alcian blue/nuclear fast red staining. In addition, DSCG showed a significant inhibitory effect on anti-dinitrophenyl IgE-mediated tumor necrosis factor-alpha production. These results indicate that DSCG inhibits mast cell-mediated immediate-type allergic reaction.

  7. Evaluation of fever in the immediate postoperative period in patients who underwent total joint arthroplasty.

    Science.gov (United States)

    Athanassious, Christian; Samad, Adil; Avery, Anthony; Cohen, Jason; Chalnick, David

    2011-12-01

    Forty percent to 50% of patients may experience an immediate postoperative fever. Research suggests that these are of aseptic cause due to inflammatory mediators. This is a retrospective analysis of fevers in total hip arthroplasty (THA) and total knee arthroplasty (TKA) patients from 2006 to 2008. Thirty-six percent of THA and 31% of TKA patients developed a fever, with most developing a maximum temperature on postoperative day (POD) 2. The maximum mean temperature between the THA and TKA group was not significantly different. Fevers in the immediate postoperative period are a normal variant in patients undergoing THA or TKA. Urinalysis, urine culture and sensitivity, and chest x-ray are not required during this period because most of these fevers stem from aseptic causes. Copyright © 2011 Elsevier Inc. All rights reserved.

  8. Reduction in exhaled nitric oxide immediately after methacholine challenge in asthmatic children

    Science.gov (United States)

    Piacentini, G; Bodini, A; Peroni, D; Del Giudice, M M.; Costella, S; Boner, A

    2002-01-01

    Background: The measurement of exhaled nitric oxide (NO) has recently been proposed as a useful technique for the evaluation of airway inflammation in asthma. The purpose of this study was to determine the effect of methacholine bronchial provocation on the levels of exhaled NO in asthmatic children. Method: Exhaled NO was measurement immediately before and after methacholine provocation in 51 children with mild to moderate asthma. Results: A significant decrease occurred in the level of exhaled NO (p<0.0001) after methacholine bronchial provocation which was not correlated with the percentage fall in forced expiratory volume in 1 second (FEV1). Conclusions: The methacholine test should not be used immediately before measurement of exhaled NO in children with asthma. PMID:12200520

  9. Use of transitional implants for immediate loading in mandibular complete dentures- A case report

    Directory of Open Access Journals (Sweden)

    Seema Bhoosreddy

    2009-01-01

    Full Text Available After the placement of implants in areas in which several teeth have been lost, both the clinician and the patient face many difficulties, particularly during healing. If no prosthesis is provided, the patient′s quality of life suffers. If a removable prosthesis is provided for optimum mastication and speech, many complicated adjustments of the denture may become necessary during healing, and the possibility of osseointegration failure increases. It has been reported that for implants to become osseointegrated, they must heal in the absence of functional loads for 4 to 6 months. To address the need for undisturbed healing and patient demand for uninterrupted immediate function and esthetics, the transitional implant system has been developed. This case report describes the use of transitional implants to support a removable mandibular overdenture. The transitional implant system is a sound and economical method of immediate patient restoration that allows for the protected healing of submerged implants.

  10. Written object naming, spelling to dictation, and immediate copying: Different tasks, different pathways?

    Science.gov (United States)

    Bonin, Patrick; Méot, Alain; Lagarrigue, Aurélie; Roux, Sébastien

    2015-01-01

    We report an investigation of cross-task comparisons of handwritten latencies in written object naming, spelling to dictation, and immediate copying. In three separate sessions, adults had to write down a list of concrete nouns from their corresponding pictures (written naming), from their spoken (spelling to dictation) and from their visual presentation (immediate copying). Linear mixed models without random slopes were performed on the latencies in order to study and compare within-task fixed effects. By-participants random slopes were then included to investigate individual differences within and across tasks. Overall, the findings suggest that written naming, spelling to dictation, and copying all involve a lexical pathway, but that written naming relies on this pathway more than the other two tasks do. Only spelling to dictation strongly involves a nonlexical pathway. Finally, the analyses performed at the level of participants indicate that, depending on the type of task, the slower participants are more or less influenced by certain psycholinguistic variables.

  11. Evaluation of immediate breast reconstruction and radiotherapy: Factors associated with complications; Reconstruction mammaire immediate apres mastectomie suivie de radiotherapie: facteurs de risque de complications

    Energy Technology Data Exchange (ETDEWEB)

    Gross, E.; Cowen, D. [Departement de radiotherapie, hopital de la Timone, 13 - Marseille (France); Hannoun-Levi, J.M. [Departement de radiotherapie, centre Antoine-Lacassagne, 06 - Nice (France); Rouanet, P. [Departement de chirurgie, centre Val-d' Aurelle-Paul-Lamarque, 34 - Montpellier (France); Houvenaeghel, G. [Departement de chirurgie, institut Paoli-Calmettes, 13 - Marseille (France); Teissier, E. [Centre azureen de cancerologie, 06 - Mougins (France); Ellis, S. [Centre catalan d' oncologie, 66 - Perpignan (France); Resbeut, M. [Centre de radiotherapie Saint-Louis, 83 - Toulon (France); Tallet, A. [Departement de radiotherapie, institut Paoli-Calmettes, 13 - Marseille (France); Vaini Cowen, V. [Departement de chirurgie gynecologique, polyclinique du Parc-Rambot, 13 - Aix-en-Provence (France); Azria, D. [Departement de radiotherapie, centre Val-d' Aurelle-Paul-Lamarque, 34 - Montpellier (France)

    2010-12-15

    Objectives: To determine prospectively the factors associated with reconstruction failure (i.e. requiring expander removal) and capsular contracture in patients undergoing mastectomy and immediate two-stage breast reconstruction with a tissue expander and implant, and radiotherapy for breast cancer. This is a multi-institutional prospective non-randomized trial. Patients and Methods: Between 2/1998 and 9/2006, we prospectively evaluated 141 consecutive patients who received 141 implants after mastectomy and underwent chest wall radiotherapy (46 to 50 Gy in 23 to 25 fractions). Patients were evaluated after 24 to 36 months by two senior physicians (radiation oncologist and surgeon). Results: Medical follow-up was 37 months. Baker 1 and 2 capsular contracture was observed in 67.5% of patients, Baker 3 and 4 in 32.5%. There were 32 reconstruction failures. In a univariate analysis, the following factors were associated with Baker 3 and 4 capsular contracture: surgeon, use of hormonotherapy and smoking, of which only one remained in the multivariate analysis: surgeon. In a univariate analysis, the following factors were associated with reconstruction failure: tumor size T3 or T4, smoking, pN+ axilla. Three factors remained associated with reconstruction failure in a multiple logistic regression: large tumors T3/T4, smoking and pN+ axilla. Conclusions: Mastectomy, radiotherapy and immediate breast reconstruction with a tissue expander and implant should be considered when breast conserving surgery has been denied. Adequate patients can be easily selected by using three factors of favourable outcome. (authors)

  12. Immediate 3-dimensional ridge augmentation after extraction of periodontally hopeless tooth using chinblock graft

    OpenAIRE

    Desai, Ankit; Thomas, Raison; Baron, Tarunkumar A.; Shah, Rucha; Mehta, Dhoom Singh

    2015-01-01

    Background The aim of the present study was to evaluate clinically and radiographically, the efficacy of immediate ridge augmentation to reconstruct the vertical and horizontal dimensions at extraction sites of periodontally hopeless tooth using an autogenous chin block graft. Material and Methods A total of 11 patients (7 male & 4 female) with localized advanced bone loss around single rooted teeth having hopeless prognosis and indicated for extraction were selected for the study. The teeth ...

  13. Immediate Effects of Repetitive Magnetic Stimulation on Single Cortical Pyramidal Neurons

    Science.gov (United States)

    Banerjee, Jineta; Sorrell, Mary E.; Celnik, Pablo A.; Pelled, Galit

    2017-01-01

    Repetitive Transcranial Magnetic Stimulation (rTMS) has been successfully used as a non-invasive therapeutic intervention for several neurological disorders in the clinic as well as an investigative tool for basic neuroscience. rTMS has been shown to induce long-term changes in neuronal circuits in vivo. Such long-term effects of rTMS have been investigated using behavioral, imaging, electrophysiological, and molecular approaches, but there is limited understanding of the immediate effects of TMS on neurons. We investigated the immediate effects of high frequency (20 Hz) rTMS on the activity of cortical neurons in an effort to understand the underlying cellular mechanisms activated by rTMS. We used whole-cell patch-clamp recordings in acute rat brain slices and calcium imaging of cultured primary neurons to examine changes in neuronal activity and intracellular calcium respectively. Our results indicate that each TMS pulse caused an immediate and transient activation of voltage gated sodium channels (9.6 ± 1.8 nA at -45 mV, p value rTMS stimulation induced action potentials in a subpopulation of neurons, and significantly increased the steady state current of the neurons at near threshold voltages (at -45 mV: before TMS: I = 130 ± 17 pA, during TMS: I = 215 ± 23 pA, p value = 0.001). rTMS stimulation also led to a delayed increase in intracellular calcium (153.88 ± 61.94% increase from baseline). These results show that rTMS has an immediate and cumulative effect on neuronal activity and intracellular calcium levels, and suggest that rTMS may enhance neuronal responses when combined with an additional motor, sensory or cognitive stimulus. Thus, these results could be translated to optimize rTMS protocols for clinical as well as basic science applications. PMID:28114421

  14. Pharmacological and clinical evidence of nevirapine immediate- and extended-release formulations

    Directory of Open Access Journals (Sweden)

    Ena J

    2012-11-01

    Full Text Available Javier Ena, Concepción Amador, Conxa Benito, Francisco PasquauHIV Unit, Hospital Marina Baixa, Villajoyosa, SpainAbstract: We reviewed the current information available on nevirapine immediate- and extended-release formulations and its role in single-dose and combination antiretroviral therapy. Nevirapine was approved in 1996 and was the first non-nucleoside reverse-transcriptase inhibitor available for the treatment of HIV-1 infection. Nevirapine has demonstrated good efficacy and a well-characterized safety profile. A major drawback is the low genetic barrier, allowing the emergence of resistance in the presence of single mutations in the reverse-transcriptase gene. This shortcoming is particularly relevant when nevirapine is administered in a single dose to prevent mother-to-child transmission of HIV-1 infection, compromising the efficacy of future non-nucleoside reverse transcriptase–inhibitor regimens. Studies published recently have probed the noninferiority of nevirapine compared to ritonavir-boosted atazanavir with both tenofovir disoproxil fumarate and emtricitabine in antiretroviral treatment–naïve patients. In 2011, a new formulation of nevirapine (nevirapine extended release that allowed once-daily dosing was approved by the Food and Drug Administration and by the European Medicines Agency. VERxVe, a study comparing nevirapine extended release with nevirapine immediate release in antiretroviral treatment–naïve patients, and TRANxITION, a study carried out in antiretroviral treatment–experienced patients who switched therapy from nevirapine immediate release to nevirapine extended release, provided data on the noninferiority of the new formulation of nevirapine compared with nevirapine immediate release in terms of efficacy and safety. Nevirapine extended release will further increase the durability and persistence of nevirapine-containing antiretroviral therapy, allowing once-daily dosing regimens.Keywords: nevirapine

  15. Transcriptional dynamics reveal critical roles for non-coding RNAs in the immediate-early response.

    Directory of Open Access Journals (Sweden)

    Stuart Aitken

    2015-04-01

    Full Text Available The immediate-early response mediates cell fate in response to a variety of extracellular stimuli and is dysregulated in many cancers. However, the specificity of the response across stimuli and cell types, and the roles of non-coding RNAs are not well understood. Using a large collection of densely-sampled time series expression data we have examined the induction of the immediate-early response in unparalleled detail, across cell types and stimuli. We exploit cap analysis of gene expression (CAGE time series datasets to directly measure promoter activities over time. Using a novel analysis method for time series data we identify transcripts with expression patterns that closely resemble the dynamics of known immediate-early genes (IEGs and this enables a comprehensive comparative study of these genes and their chromatin state. Surprisingly, these data suggest that the earliest transcriptional responses often involve promoters generating non-coding RNAs, many of which are produced in advance of canonical protein-coding IEGs. IEGs are known to be capable of induction without de novo protein synthesis. Consistent with this, we find that the response of both protein-coding and non-coding RNA IEGs can be explained by their transcriptionally poised, permissive chromatin state prior to stimulation. We also explore the function of non-coding RNAs in the attenuation of the immediate early response in a small RNA sequencing dataset matched to the CAGE data: We identify a novel set of microRNAs responsible for the attenuation of the IEG response in an estrogen receptor positive cancer cell line. Our computational statistical method is well suited to meta-analyses as there is no requirement for transcripts to pass thresholds for significant differential expression between time points, and it is agnostic to the number of time points per dataset.

  16. Visual memory in unilateral spatial neglect: immediate recall versus delayed recognition.

    Science.gov (United States)

    Moreh, Elior; Malkinson, Tal Seidel; Zohary, Ehud; Soroker, Nachum

    2014-09-01

    Patients with unilateral spatial neglect (USN) often show impaired performance in spatial working memory tasks, apart from the difficulty retrieving "left-sided" spatial data from long-term memory, shown in the "piazza effect" by Bisiach and colleagues. This study's aim was to compare the effect of the spatial position of a visual object on immediate and delayed memory performance in USN patients. Specifically, immediate verbal recall performance, tested using a simultaneous presentation of four visual objects in four quadrants, was compared with memory in a later-provided recognition task, in which objects were individually shown at the screen center. Unlike healthy controls, USN patients showed a left-side disadvantage and a vertical bias in the immediate free recall task (69% vs. 42% recall for right- and left-sided objects, respectively). In the recognition task, the patients correctly recognized half of "old" items, and their correct rejection rate was 95.5%. Importantly, when the analysis focused on previously recalled items (in the immediate task), no statistically significant difference was found in the delayed recognition of objects according to their original quadrant of presentation. Furthermore, USN patients were able to recollect the correct original location of the recognized objects in 60% of the cases, well beyond chance level. This suggests that the memory trace formed in these cases was not only semantic but also contained a visuospatial tag. Finally, successful recognition of objects missed in recall trials points to formation of memory traces for neglected contralesional objects, which may become accessible to retrieval processes in explicit memory.

  17. Effect of a contact monitoring system with immediate visual feedback on hand hygiene compliance.

    Science.gov (United States)

    Storey, S J; FitzGerald, G; Moore, G; Knights, E; Atkinson, S; Smith, S; Freeman, O; Cryer, P; Wilson, A P R

    2014-10-01

    Hand hygiene compliance is traditionally monitored by visual methods that are open to bias and strictly limited in time and place. Automatic monitoring may be more effective for infection control as well as performance management. To establish accuracy and acceptability of an automatic contact monitoring system for hand hygiene. Monitoring equipment was installed across 55 beds in three wards, and included modified identity badges, bedside furniture, sinks and alcohol gel dispensers. Badges were in near-skin contact (through uniform) and could detect alcohol vapour. All devices were linked by wi-fi. A traffic light system on the badge provided immediate feedback to staff and patients on the hand hygiene status of a member of staff on approach to a patient. Compliance was logged automatically. Following a period of immediate feedback, no visual feedback was given for two weeks. Subsequently, feedback was given using red/green lights for 10 days, followed by retrospective feedback to the ward. Hand hygiene was verified independently by an observer. Hand hygiene compliance increased from 21% of 97 opportunities to 66% of 197 opportunities during active immediate feedback. Compliance decreased when feedback was provided to wards retrospectively. Six staff (26%) avoided wearing a badge, saying that it was too heavy or they were not on the ward all day. Only three of 30 patients stated that they would challenge staff who had not performed hand hygiene. Automatic contact monitoring with immediate feedback was effective in increasing hand hygiene compliance, but feedback given retrospectively did not prevent a decrease in compliance. Copyright © 2014 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

  18. Effects of nitroglycerin ointment on mastectomy flap necrosis in immediate breast reconstruction: a randomized controlled trial.

    Science.gov (United States)

    Gdalevitch, Perry; Van Laeken, Nancy; Bahng, Seokjae; Ho, Adelyn; Bovill, Esta; Lennox, Peter; Brasher, Penelope; Macadam, Sheina

    2015-06-01

    Mastectomy flap necrosis is a common complication of immediate breast reconstruction that impacts recovery time and reconstructive success. Nitroglycerin ointment is a topical vasodilator that has been shown to improve skin flap survival in an animal model. The objective of this study was to evaluate whether the application of nitroglycerin ointment to the breast skin after mastectomy and immediate reconstruction causes a decrease in the rate of mastectomy flap necrosis compared with placebo. This study was conducted as a randomized controlled trial and included patients aged 21 to 69 years undergoing mastectomy and immediate breast reconstruction at the University of British Columbia-affiliated hospitals (Vancouver, British Columbia, Canada). Patients with a medical history that precluded the administration of nitroglycerin were excluded from the study. The target sample size was 400 patients. Nitroglycerin ointment (45 mg) or a placebo was applied to the mastectomy skin at the time of surgical dressing. The trial was stopped at the first interim analysis after 165 patients had been randomized (85 to the treatment group and 80 to the placebo group). Mastectomy flap necrosis developed in 27 patients (33.8 percent) receiving placebo and in 13 patients (15.3 percent) receiving nitroglycerin ointment; the between-group difference was 18.5 percent (p = 0.006; 95 percent CI, 5.3 to 31.0 percent). Postoperative complications were similar in both groups [nitroglycerin, 22.4 percent (19 of 85); placebo, 28.8 percent (23 of 80)]. In patients undergoing mastectomy and immediate reconstruction, there was a marked reduction in mastectomy flap necrosis in patients who received nitroglycerin ointment. Nitroglycerin ointment application is a simple, safe, and effective way to help prevent mastectomy flap necrosis. Therapeutic, I.

  19. Meditation-Based Treatment Yielding Immediate Relief for Meditation-Naïve Migraineurs

    OpenAIRE

    Tonelli, Makenzie E.; Wachholtz, Amy B.

    2012-01-01

    Meditation is gaining popularity as an effective means of managing and attenuating pain and has been particularly effective for migraines. Meditation additionally addresses the negative emotional states known to exist with migraines. The purpose of this study was to evaluate the effectiveness of meditation as an immediate intervention for reducing migraine pain as well as alleviating emotional tension, examined herein as a negative affect hypothesized to be correlated with pain. Twenty-seven ...

  20. Design and development of bilayer tablet for immediate and extended release of acarbose and metformin HCl

    OpenAIRE

    Meenakshi Joshi; Ruchi Tiwari; Gaurav Tiwari

    2014-01-01

    The present investigation studied a novel Bilayer tablet having extended release (ER) system of metformin HCl (M.HCl) with Eudragit RS 100 and RL 100 and immediate release (IR) system of Acarbose with PVP K30 and PEG 6000 in different ratios using solvent evaporation technique. Solid dispersions (SDs) were characterized by Fourier Transform-Infra Red spectroscopy, Diffrential Scanning Calorimetry, X-Ray Diffractometry and Scanning Electron Microscopy. Selected SD system was subjected to Bilay...

  1. CLINICAL CONSIDERATIONS OF DENTAL IMPLANT SYSTEM IN IMMEDIATE LOADING IMPLANT CASES

    OpenAIRE

    2015-01-01

    Immediate loading of dental implant has been researched intensively in the development of Branemark’s early concept of 2 stages implant placement. This was embarked from both patients and practiitioner’s convenience towards a simpler protocol and shorter time frame. Many recent researchers later found that micromotions derived from occlusal loading for a certain degree, instead of resulting a fibrous tissue encapsulation, can enhance the osseointegration process. Dental Implant system enhance...

  2. A Comparison of Betadine, Sterillium and Silver Nanocolloid Immediate Effect on Surgical Hand Antiseptic

    OpenAIRE

    Seyyed Mostafa Shiryazdi; Mohaddeseh Aboueian-Jahromi; Hajieih-Fatemeh Mollahoseini; Khadijeh Amrollahi; Hamid Reza paydar; Hasan Barzegar Bafrouei

    2014-01-01

    Background and Aim: To reduce surgical site infections and its complications, hand antiseptic is performed on the basis of product type either by rubbing or washing method. Silver Nanocolloid is a wide range disinfectant entered in world and also Iran markets as a surgical hand antiseptic, but any study about this subject hasn’t yet conducted. The aim of this study is comparing of Betadine, Sterillium and Silver Nanocolloid immediate effect on surgical hand antiseptic. Materials and Method...

  3. The Analysis of two-months effects of muscle stretching. Immediately following injection of methyl prednisolon

    OpenAIRE

    L. Bidkoli; A.H. Yazdani; A.R.Moghtaderi; Sh. Mirshams,; M.R. Emad

    2008-01-01

    AbstractBackground and Purpose: Trigger points have been described as causing pain in clinical practice and are a common source of musculoskeletal pain. Trigger point injection can effectively inactivate the trigger points and provide symptomatic relief. Efficacy of injection in the treatment of trigger points depends strongly on the technique of trigger point injection. This study compares muscle stretching immediately after injection of methyl prednisolon vs. injection without stretching in...

  4. Immediate And Retention Effects Of Teaching Games For Understanding Approach On Basketball Knowledge

    Directory of Open Access Journals (Sweden)

    Olosová Gabriela

    2015-05-01

    Full Text Available Teaching Games for Understanding (TGfU links tactics and skills by emphasizing the appropriate timing and application within the tactical context of the game. It has been linked to the development of enhanced tactical knowledge. The purpose of the study was to determine immediate and delayed effects of TGfU on procedural and declarative knowledge of basketball and to compare it with a technical approach. Experimental group (EG (11 fifth graders + 18 sixth graders was taught by TGfU and a control group (CG (16 fifth graders + 24 sixth graders was taught by a technical approach for 8 weeks in Physical Education (PE classes, both. A written test was constructed to evaluate pupils’ declarative and procedural knowledge of basketball. The test was applied after the intervention to determine immediate effects and 8 months after the intervention to determine retention effects of the experimental programme. Shapiro-Wilk test, Wilcoxon T-test, Man-Whitney U-test were used for statistical analysis of obtained data. Cohen’s d was used to calculate effect size. Generally basketball knowledge was better in EG than in CG after the intervention (p<0.05 what confirms moderate effect size. When declarative and procedural knowledge were analysed separately there was no significant difference between EG and CG. Nevertheless, moderate effect sizes indicate that the data are particularly meaningful in terms of school practice. Retention effects of both approaches were similar. Total knowledge and declarative knowledge were worse after 8 months than immediately after the intervention in both groups (p<0.01. In both groups, there was no significant difference in procedural knowledge between the test written immediately after the intervention and 8 months later. Differences of changes were not significant between the groups.

  5. Evaluation of Role Played by Mediators of Immediate Hypersensitivity in Exercise-induced Asthma

    OpenAIRE

    Deal, E. Chandler; Wasserman, Stephen I.; Soter, Nicholas A.; Ingram, R. H.; McFadden, E. R.

    1980-01-01

    To determine whether mediators of immediate hypersensitivity played a role in the pathogenesis of exercise-induced asthma, we measured the concentration of histamine and neutrophil-chemotactic activity present in systemic arterial blood during thermal challenges in five asymptomatic asthmatics. Because exercise-induced asthma has been shown to be a result of respiratory heat loss and because respiratory heat loss during isocapnic hyperventilation has been shown to give identical responses, we...

  6. IMMEDIATE POST - OPERATIVE VENTRICULAR BIGEMINY IN A PATIENT OPERATED FOR OVARIAN CYSTECTOMY : A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Vijay Narayanan

    2015-06-01

    Full Text Available A 30 year s female who was recently diagnosed as RHD with MR was posted for Rt. Ovarian cystectomy. Immediately after extubation she was having continuous ventricular bigeminy which persisted even after giving 60mg of 2% lignocaine i.v. Later 2mg of metoprolol was given which stopped the ventricular ectopics from occurring. The case report discusses the successful treatment of the ventricular bigeminy and the prevention of any c omplications from arising in this particular patient.

  7. Immediate reactions following iodinated contrast media injection: A study of 38 cases

    Energy Technology Data Exchange (ETDEWEB)

    Dewachter, Pascale, E-mail: pascale.dewachter@yahoo.fr [Service d' Anesthesie-Reanimation Chirurgicale and SAMU de Paris, Hopital Necker-Enfants Malades, AP-HP, Universite Paris-Descartes, 149 Rue de Sevres, 75015 Paris (France); Laroche, Dominique, E-mail: laroche-do@chu-caen.fr [Service de Biophysique, Centre Hospitalier Universitaire, Avenue de la Cote de Nacre, Caen (France); Mouton-Faivre, Claudie, E-mail: claudie.mouton@wanadoo.fr [Pole d' Anesthesie-Reanimation Chirurgicale, Centre Hospitalier Universitaire-Hopital Central, Avenue du Marechal de Lattre de Tassigny, Nancy (France); Bloch-Morot, Evelyne, E-mail: ebloch-morot@club-internet.fr [Service de Medecine Interne, Hopital Europeen Georges Pompidou, 20 Rue Leblanc, Paris (France); Cercueil, Jean-Pierre, E-mail: jean-pierre.cercueil@chu-dijon.fr [Departement d' Imagerie Medicale, Centre Hospitalier Universitaire, Hopital du Bocage, 2, Boulevard du Marechal de Lattre de Tassigny, Dijon (France); Metge, Liliane, E-mail: liliane.metge@chu-nimes.fr [Departement d' Imagerie Medicale, Centre Hospitalier Universitaire Caremeau, Place du Pr Robert Debre, Nimes (France); Carette, Marie-France, E-mail: marie-france.carette@tnn.ap-hop-paris.fr [Service de Radiologie, Hopital Tenon, 4 Rue de la Chine, Paris (France); Vergnaud, Marie-Claude, E-mail: vergnaud-mc@chu-caen.fr [Service de Medecine Polyvalente, Centre Hospitalier Universitaire, Avenue de la Cote de Nacre, Caen (France); Clement, Olivier, E-mail: olivier.clement@inserm.fr [Service de Radiologie, Hopital Europeen Georges Pompidou, AP-HP, Universite Paris Descartes, 20 Rue Leblanc, Paris (France)

    2011-03-15

    Objectives: To investigate the pathomechanisms involved in cases of immediate hypersensitivity reactions occurring after the administration of iodinated contrast media. Materials and methods: Patients having presented clinical signs of immediate hypersensitivity suggesting allergy after iodinated contrast medium were investigated. Histamine and tryptase concentrations were measured, and/or skin tests were performed. Patients with positive skin tests to the culprit contrast agent were classified as IgE-mediated allergic hypersensitivity (Group I) and patients with negative skin tests as non-allergic hypersensitivity (Group II). Results: 38 patients were included. Most reactions appeared after non-ionic (n = 32). Reactions were more frequently severe following ionic than non-ionic (p = 0.014). Skin testing was not performed in 11 patients. Skin tests with the culprit contrast agent were negative in 26% of the patients (Group II, n = 7) whereas they were found positive with the contrast agent in 73% of the patients (Group I, n = 19). Latex-induced reaction was diagnosed in one patient, and was consequently excluded from the cohort. In Group I, the frequency of cross-reactivity with the other commercialized iodinated contrast media was low (7%). Cardiovascular signs were present in Group I (52.6%, n = 10), and absent in Group II (p = 0.023). Histamine and tryptase concentrations were higher in patients who had cardiovascular signs (p < 0.02). Conclusion: Immediate reactions with clinical signs suggesting allergy along with positive skin tests with the administered contrast agent confirm immediate allergic hypersensitivity (anaphylaxis) to this agent. Consequently, the culprit contrast agent should be definitely avoided as well as cross-reactive ICM in order to prevent further recurrences.

  8. Immediate differentiation of salmonella-resembling colonies on brilliant green agar

    DEFF Research Database (Denmark)

    Jensen, Annette Nygaard; Hoorfar, Jeffrey

    2000-01-01

    A rapid biochemical system (OBIS) based on immediate enzymatic differentiation of Citrobacter, Proteus, Providencia, Hafnia and Morganella spp. from Salmonella on brilliant green agar was evaluated A total of 96 field isolates from various Salmonella serotypes, 18 Citrobacter freundii and 25...... isolates of other Enterobacteriaceae were tested All Salmonella isolates were identified correctly by the kit, and none of the Enterobacteriaceae isolates were identified as Salmonella. The results indicate complete specificity for Salmonella colonies on brilliant green agar....

  9. When does word meaning affect immediate serial recall in semantic dementia?

    OpenAIRE

    Jefferies, Elizabeth; Jones, Roy; Bateman, David; Lambon Ralph, Matthew A.

    2004-01-01

    Patients with semantic dementia can show superior immediate recall of words that they still understand relatively well, as compared with more semantically degraded words, suggesting that conceptual knowledge makes a major contribution to phonological short-term memory. However, a number of studies have failed to show such a recall difference, challenging this view. We examined the effect of several methodological factors on the recall of known and degraded words in 4 patients with semantic de...

  10. Changes in psychosocial functioning 1 year after mastectomy alone, delayed breast reconstruction, or immediate breast reconstruction.

    Science.gov (United States)

    Metcalfe, Kelly A; Semple, John; Quan, May-Lynn; Vadaparampil, Susan T; Holloway, Claire; Brown, Mitch; Bower, Bethanne; Sun, Ping; Narod, Steven A

    2012-01-01

    In this study, we report on the changes in psychosocial functioning over 1 year following breast cancer surgery in 3 groups of women, including those with mastectomy alone, those with mastectomy and immediate reconstruction, and those with delayed reconstruction. Women with breast cancer at 2 teaching hospitals in Ontario who were undergoing mastectomy alone, mastectomy with immediate reconstruction, or delayed reconstruction were asked to complete a battery of psychosocial questionnaires at their preoperative appointment and 1 year following surgery. A total of 190 women consented to participate in the study and completed the presurgical questionnaires. There were no presurgical differences between the 3 groups in quality of life, anxiety, depression, or sexual functioning. However, women who were undergoing delayed breast reconstruction (i.e., already had a mastectomy) had higher levels of body stigma (P = 0.01), body concerns (P = 0.002), and transparency (P = 0.002) than women who were undergoing mastectomy alone or mastectomy with immediate reconstruction. Of these women, 158 (83.2%) completed the 1-year follow-up. There were no significant differences in any of the psychosocial functioning scores between the 3 groups. Contrary to the assumed psychological benefits of breast reconstruction, psychological distress was evident among women regardless of reconstruction or timing of reconstruction. Further, psychosocial functioning (including quality of life, sexual functioning, cancer-related distress, body image, depression, and anxiety) was not different at 1-year postsurgery between women with mastectomy alone, mastectomy with immediate reconstruction, and delayed reconstruction. These results suggest that women need psychosocial support after breast cancer diagnosis, even if they have breast reconstruction.

  11. Is immediate adjunctive CBT more beneficial than delayed CBT in treating depression?: A Pilot Study.

    Science.gov (United States)

    Rizvi, Sakina J; Zaretsky, Ari; Schaffer, Ayal; Levitt, Anthony

    2015-03-01

    Cognitive-behavioral therapy (CBT) is an efficacious first-line therapy for patients with major depressive disorder (MDD). Due to the limited accessibility of CBT, long wait lists result in delayed treatment, which may affect treatment outcomes. The goal of this pilot study was to obtain preliminary data from a randomized controlled trial to determine whether delayed CBT reduces the effectiveness of the therapy compared to immediate CBT in patients with MDD receiving pharmacotherapy. Patients were randomized to receive immediate CBT (n=18) or to begin CBT after 6 months (n=20) and received 14 weekly sessions, followed by two additional booster sessions. During the active treatment months, patients in the immediate group demonstrated reductions in scores on the Beck Depression Inventory II (BDI-II) that were similar to those in the delayed CBT group. However, when the analysis was performed using only data from patients in the delayed group who were still in a depressive episode, there was an overall greater decrease in BDI-II scores in the immediate group vs. the delayed group over the active treatment months, but not specifically at the 6-month endpoint. These findings suggest delays in depression treatment, similar to what occurs with real-world wait list times, may not have a significant impact on the effectiveness of CBT in patients who are already receiving treatment as usual. However, such delays may affect the effectiveness of CBT in those patients who remain depressed during the time delay. A larger trial is necessary to confirm these findings. (Journal of Psychiatric Practice 2015;21:107-113).

  12. Regulation of BDNF-mediated transcription of immediate early gene Arc by intracellular calcium and calmodulin

    OpenAIRE

    Zheng, Fei; Luo, Yongneng; Wang, Hongbing

    2009-01-01

    The induction of the immediate early gene Arc is strongly implicated in synaptic plasticity. Although the role of ERK was demonstrated, the regulation of Arc expression is largely unknown. In this study, we investigated the major signaling pathways underlying brain-derived neurotrophic factor (BDNF)-mediated Arc transcription in cultured cortical neurons. The BDNF-stimulated Arc transcription was solely regulated by the Ras-Raf-MAPK signaling through ERK, but not by phosphoinositide 3-kinase ...

  13. Immediate loading of postextraction implants in the esthetic area: systematic review of the literature.

    Science.gov (United States)

    Del Fabbro, Massimo; Ceresoli, Valentina; Taschieri, Silvio; Ceci, Caterina; Testori, Tiziano

    2015-02-01

    The purpose of the present systematic review was to estimate the survival rate of implants placed in fresh extraction sockets and immediately restored. Secondary aims were to compare it with the survival rate of implants placed in healed ridges and of implants restored according to a delayed protocol as well as to assess the influence of several other confounding factors on the clinical outcomes. An electronic search was performed on MEDLINE, EMBASE, and CENTRAL databases in order to identify prospective clinical studies published from 1990 to October 2012. A hand search was also done. Studies were selected according to specific inclusion criteria. The effect of the following parameters on 1-year implant survival (IS) was statistically evaluated: study design, risk of bias, prosthesis type, type of loading (occlusal or nonocclusal), type of incision (flap or flapless), presence of infection, and grafting material. A meta-analysis of studies comparing immediately restored implants placed in fresh postextraction sockets versus healed ridges was conducted. Seven randomized trials, three controlled trials, and 35 case series were included, accounting for 1170 patients and 1974 postextraction implants immediately restored. Twenty-eight studies had a low risk of bias. The overall 1-year IS was 97.6%. All failures occurred within 1 year of function. Meta-analysis showed a significant better outcome for implants placed in healed ridge (IS = 99.4%) as compared with postextraction implants (IS = 95.6%). No other parameter had a significant effect on clinical outcomes. Most variables, among which the esthetic aspect, could not be assessed as they were not systematically reported. Though the conventional protocol still represents the gold standard, immediate restoration of implants placed in fresh extraction sites displayed an excellent implant prognosis. Such clinical approach can be successfully adopted in order to minimize the treatment time with a relevant impact

  14. The Psycho-social Context of Panic Disorder (Barriers in Communication with the Client's Immediate Environment)

    OpenAIRE

    Svitáková, Marie

    2010-01-01

    The thesis entitled Psychosocial Context of the Panic Disorder; Barriers in Communication with the Client's Immediate Environment traces the influence of panic disorder on the social aspects of the client's life. The thesis attempts to define the term panic disorder, traces selected treatment possibilities, characterizes the panic attack and describes the impact of the panic disorder on the behaviour and mentality of the patient. Further, it focuses on the communication of non-psychiatric med...

  15. Long-Term Maintenance of Immediate or Delayed Extinction Is Determined by the Extinction-Test Interval

    Science.gov (United States)

    Johnson, Justin S.; Escobar, Martha; Kimble, Whitney L.

    2010-01-01

    Short acquisition-extinction intervals (immediate extinction) can lead to either more or less spontaneous recovery than long acquisition-extinction intervals (delayed extinction). Using rat subjects, we observed less spontaneous recovery following immediate than delayed extinction (Experiment 1). However, this was the case only if a relatively…

  16. 41 CFR 102-74.255 - How must occupant evacuation or relocation be accomplished when there is immediate danger to...

    Science.gov (United States)

    2010-07-01

    ... evacuation or relocation be accomplished when there is immediate danger to persons or property, such as fire... danger to persons or property, such as fire, explosion or the discovery of an explosive device (not... immediate danger to persons or property, such as fire, explosion or the discovery of an explosive...

  17. The Angio-Seal™ femoral closure device allows immediate ambulation after coronary angiography and percutaneous coronary intervention

    DEFF Research Database (Denmark)

    Hvelplund, Anders; Jeger, Raban; Osterwalder, Remo;

    2011-01-01

    Aims: To test the safety of immediate mobilisation of patients undergoing coronary angiography and percutaneous coronary intervention (PCI) closed with Angio-Seal™ -a femoral vascular closure device. Methods and results: First, a randomised controlled trial of immediate mobilisation vs. delayed a...

  18. The Contributions of Primary and Secondary Memory to Working Memory Capacity: An Individual Differences Analysis of Immediate Free Recall

    Science.gov (United States)

    Unsworth, Nash; Spillers, Gregory J.; Brewer, Gene A.

    2010-01-01

    The present study tested the dual-component model of working memory capacity (WMC) by examining estimates of primary memory and secondary memory from an immediate free recall task. Participants completed multiple measures of WMC and general intellectual ability as well as multiple trials of an immediate free recall task. It was demonstrated that…

  19. 76 FR 64401 - Self-Regulatory Organizations; NASDAQ OMX PHLX LLC; Notice of Filing and Immediate Effectiveness...

    Science.gov (United States)

    2011-10-18

    ... assigns each order an equal probability of execution. Example: The book has four minimum quantity orders... Hours Immediate or Cancel. As a result, the order can only be used to ``ping'' the PSX book to see if... restriction so that a Minimum Quantity Order could post to the book if it cannot be executed immediately....

  20. Examining the Relationship between Free Recall and Immediate Serial Recall: The Role of List Length, Strategy Use, and Test Expectancy

    Science.gov (United States)

    Grenfell-Essam, Rachel; Ward, Geoff

    2012-01-01

    Recent findings suggest that the immediate free recall (IFR) of short lists is similar to immediate serial recall (ISR). These findings were obtained using a methodology in which participants did not know the list length in advance of each list, and this uncertainty may have encouraged participants to adopt atypical recall strategies. Therefore,…

  1. Self-control and the effects of movie alcohol portrayals on immediate alcohol consumption in male college students

    NARCIS (Netherlands)

    Koordeman, R.; Anschutz, D.J.; Engels, R.C.M.E.

    2015-01-01

    Background: In movies, alcohol-related cues are frequently depicted and there is evidence for a link between movie alcohol cues and immediate alcohol consumption. Less is known about factors influencing immediate effects movie alcohol exposure on drinking. The exertion of self-control is thought to

  2. Self-control and the effects of movie alcohol portrayals on immediate alcohol consumption in male college students

    NARCIS (Netherlands)

    Koordeman, R.; Anschutz, D.J.; Engels, R.C.M.E.

    2015-01-01

    Background: In movies, alcohol-related cues are frequently depicted and there is evidence for a link between movie alcohol cues and immediate alcohol consumption. Less is known about factors influencing immediate effects movie alcohol exposure on drinking. The exertion of self-control is thought to

  3. 29 CFR 779.234 - Establishments whose only regular employees are the owner or members of his immediate family.

    Science.gov (United States)

    2010-07-01

    ... sales of any enterprise for the purpose of section 3(s). The term “other member of the immediate family... or members of his immediate family. 779.234 Section 779.234 Labor Regulations Relating to Labor... Employment to Which the Act May Apply; Enterprise Coverage Leased Departments, Franchise and Other...

  4. Immediate Feedback on Accuracy and Performance: The Effects of Wireless Technology on Food Safety Tracking at a Distribution Center

    Science.gov (United States)

    Goomas, David T.

    2012-01-01

    The effects of wireless ring scanners, which provided immediate auditory and visual feedback, were evaluated to increase the performance and accuracy of order selectors at a meat distribution center. The scanners not only increased performance and accuracy compared to paper pick sheets, but were also instrumental in immediate and accurate data…

  5. The Peg-Word Mnemonic Facilitates Immediate but Not Long-Term Memory in Fifth-Grade Children.

    Science.gov (United States)

    Krinsky, Richard; Krinsky, Suzanne G.

    1994-01-01

    Two experiments examined immediate and long-term serial list learning effects for common nouns for 42 fifth graders. Results provide additional evidence that long-term forgetting may be greater for learners who receive mnemonic instruction than for untrained controls, in spite of some immediate enhanced recall. (SLD)

  6. Complete Immediate Paraplegia Reversal after Performing Aorto-Lumbar Bypass on the Patient who Underwent Aortoiliac Reconstruction.

    Science.gov (United States)

    Banzic, Igor; Sladojevic, Milos; Ilic, Nikola; Koncar, Igor; Davidovic, Lazar; Brankovic, Milos

    2016-08-01

    Although both internal iliac arteries were saved during operation, the patient developed paraplegia immediately after aortoiliac reconstruction due to the spinal cord ischemia. We report a successfully treated immediate postoperative paraplegia by performing second operation and creating bypass from the bifurcated Dacron graft to the previously detected nonpaired huge lumbar artery.

  7. Bone-Implant Contact around Crestal and Subcrestal Dental Implants Submitted to Immediate and Conventional Loading

    Directory of Open Access Journals (Sweden)

    Ana Emília Farias Pontes

    2014-01-01

    Full Text Available The present study aims to evaluate the influence of apicocoronal position and immediate and conventional loading in the percentage of bone-implant contact (BIC. Thus, 36 implants were inserted in the edentulous mandible from six dogs. Three implants were installed in each hemimandible, in different positions in relation to the ridge: Bone Level (at crestal bone level, Minus 1 (one millimeter apical to crestal bone, and Minus 2 (two millimeters apical to crestal bone. In addition, each hemimandible was submitted to a loading protocol: immediate (prosthesis installed 24 hours after implantation or conventional (prosthesis installed 120 days after implantation. Ninety days after, animals were killed, and implant and adjacent tissues were prepared for histometric analysis. BIC values from immediate loaded implants were 58.7%, 57.7%, and 51.1%, respectively, while conventional loaded implants were 61.8%, 53.8%, and 68.4%. Differences statistically significant were not observed among groups (P=0.10, ANOVA test. These findings suggest that different apicocoronal positioning and loading protocols evaluated did not interfere in the percentage of bone-implant contact, suggesting that these procedures did not jeopardize osseointegration.

  8. Speech adaptation after treatment of full edentulism through immediate-loaded implant protocols.

    Science.gov (United States)

    Molly, Liene; Nackaerts, Olivia; Vandewiele, Katrien; Manders, Eric; van Steenberghe, Daniel; Jacobs, Reinhilde

    2008-01-01

    The objective of the present study was to evaluate the influence of immediate loading of implants on speech adaptation. Ten patients (mean age 54, 6 females) were examined before surgery and 1, 3, 6 and 12 months afterwards. Articulation analysis was done using objective DAT-recoded data evaluated by two groups of speech and language therapists and a computer software program. Besides, patient VAS-scores, myofunctional problems and hearing impairment were recorded and analysed. In the present study only one patient suffered from deteriorated speech after immediate loading. Other patients showed unaffected or improved articulation 3 to 6 months after surgery with a strident and interdental pronunciation mostly becoming addental. Furthermore, myofunctional problems occurred in one patient, other patients adapted to the new situation after three months. Hearing impairment did not influence speech pathology in this study. Immediate loading of oral implants does not seem to compromise the normal 3-6 months speech adaptation period. Whether such procedure presents advantages to the conventional 2-stage rehabilitation remains to be investigated.

  9. The Effect of Learner-generated Illustrations on the Immediate And Delayed Recall of English Idioms

    Directory of Open Access Journals (Sweden)

    Afrouz Aeineh

    2014-06-01

    Full Text Available The present study investigated the effect of learner generated illustrations on the immediate and delayed idiom recall of Iranian EFL (English as a foreign language learners. To accomplish this end, 40 female students participated in this study. A placement test (Quick Placement Test, Version 2 was administered to the participants to ascertain that they were all at intermediate level of proficiency. Since the design of the study was quasi experimental, they were randomly assigned to control (N: 20 and experimental (N: 20 groups. A pretest of idioms was given to the participants to ensure that they were homogeneous in terms of their knowledge of idioms. Both groups were provided with the clarification of idioms through definitions and examples. However the experimental group was required to draw their own mental image of the idioms on a paper. At the end of the treatment, students took an immediate posttest of idioms. After an interval of 2 weeks, a similar posttest was given to the students to examine the delayed recall ability of the learners. The obtained results through an independent samples t-test indicated that the experimental group slightly outperformed the control group on immediate posttest, but the difference was not statistically significant. However the results on the delayed posttest suggested that there was a significant difference between the two groups and the participants in the experimental group had stronger delayed recall ability.

  10. Neurogenic Shock Immediately following Posterior Lumbar Interbody Fusion: Report of Two Cases.

    Science.gov (United States)

    Matsumoto, Tomiya; Okuda, Shinya; Haku, Takamitsu; Maeda, Kazuya; Maeno, Takafumi; Yamashita, Tomoya; Yamasaki, Ryoji; Kuratsu, Shigeyuki; Iwasaki, Motoki

    2015-08-01

    Study Design Case report. Objective To present two cases of neurogenic shock that occurred immediately following posterior lumbar interbody fusion (PLIF) and that appeared to have been caused by the vasovagal reflex after dural injury and incarceration of the cauda equina. Case Report We present two cases of neurogenic shock that occurred immediately following PLIF. One patient had bradycardia, and the other developed cardiac arrest just after closing the surgical incision and opening the drainage tube. Cardiopulmonary resuscitation was performed immediately, and the patients recovered successfully, but they showed severe motor loss after awakening. The results of laboratory data, chest X-ray, electrocardiogram, computed tomography, and echocardiography ruled out pulmonary embolism, hemorrhagic shock, and cardiogenic shock. Although the reasons for the postoperative shock were obscure, reoperation was performed to explore the cause of paralysis. At reoperation, a cerebrospinal fluid collection and the incarceration of multiple cauda equina rootlets through a small dural tear were observed. The incarcerated cauda equina rootlets were reduced, and the dural defect was closed. In both cases, the reoperation was uneventful. From the intraoperative findings at reoperation, it was thought that the pathology was neurogenic shock via the vasovagal reflex. Conclusion Incarceration of multiple cauda equina rootlets following the accidental dural tear by suction drainage caused a sudden decrease of cerebrospinal fluid pressure and traction of the cauda equina, which may have led to the vasovagal reflex.

  11. Immediate effects of talocrural and subtalar joint mobilization on balance in the elderly.

    Science.gov (United States)

    Chevutschi, Alain; D'Houwt, Juliette; Pardessus, Vinciane; Thevenon, André

    2015-03-01

    The aim of the present study was to evaluate the immediate effects of therapeutic mobilization of the talocrural and subtalar joints on ankle mobility and postural control in elderly subjects. Nineteen subjects (83.1 ± 6 years, 159 ± 1 cm; 56.1 ± 9.7 kg - mean ± standard deviation) participated in this study. The centre of pressure (COP) displacements along the anterior-posterior and medial-lateral axes was recorded in static and dynamic conditions on a force platform before and after therapeutic mobilization of the feet and ankles without blinding the subjects. In static conditions, the sway area is reduced contrarily to dynamic conditions where the sway area is increased. In the two experimental sessions, subjects showed comparable COP displacements and the total length of the oscillations. Results demonstrated a significant improvement immediately after mobilization for ankle range of motion in dorsal flexion (right +4.7°; left +3.2°) and plantar flexion (right 5.2°; left +4.2°). These results suggested that postural control is improved in static conditions and decreased in dynamic conditions. Therapeutic mobilization of feet and ankles in the elderly provides an immediate improvement in joint range of movement in dorsal and plantar flexion. Copyright © 2014 John Wiley & Sons, Ltd.

  12. Closed Continuous Irrigation With Lidocaine and Immediate Mobilization for Treatment of Pyogenic Tenosynovitis.

    Science.gov (United States)

    Knackstedt, Rebecca; Tyler, Joyce; Bernard, Steven

    2017-09-01

    Pyogenic flexor tenosynovitis treatment consists of either closed continuous irrigation with sterile saline or antibiotic solution, or open debridement and irrigation. These treatment approaches serve to resolve the infection, but are extremely painful and residual stiffness can be devastating to the patient. We describe herein our approach to managing pyogenic flexor tenosynovitis. To provide continuous irrigation, a butterfly catheter with needle removed is utilized with irrigation holes cut into the tubing. The catheter is inserted into the tendon sheath at the level of the Al pulley and brought out at the level of the A5 pulley. A knot is tied in the end of the catheter for retention, eliminating the need for sutures. Immediately postoperative, continuous irrigation with sterile saline mixed with lidocaine is initiated and is titrated to achieve pain-free motion in the finger. Occupational therapy begins an aggressive course of active and passive range of motion exercises immediate postoperatively, which is continued for the remainder of hospitalization. Our approach of continuous infusion of a lidocaine solution allows for pain-free movement immediately postoperatively to mechanically debride tissue, as well as allow for early active range of motion. We have obtained excelleepaknt results with this technique in all of our cases.

  13. [Acupuncture in fibromyalgia: a randomized, controlled study addressing the immediate pain response].

    Science.gov (United States)

    Stival, Rebecca Saray Marchesini; Cavalheiro, Patrícia Rechetello; Stasiak, Camila Edith Stachera; Galdino, Dayana Talita; Hoekstra, Bianca Eliza; Schafranski, Marcelo Derbli

    2014-01-01

    To evaluate the efficacy of acupuncture in the treatment of fibromyalgia, considering the immediate response of the visual analogue pain scale (VAS) as its primary outcome. Randomized, controlled, double-blind study including 36 patients with fibromyalgia (ACR 1990) selected from the outpatient rheumatology clinic, Santa Casa de Misericórdia, Ponta Grossa, PR. Twenty-one patients underwent an acupuncture session, under the principles of the traditional Chinese medicine, and 15 patients underwent a placebo procedure (sham acupuncture). For pain assessment, the subjects completed a Visual Analogue Scale (VAS) before and immediately after the proposed procedure. The mean change in VAS was compared among groups. The variation between the final and initial VAS values was -4.36±3.23 (P=0.0001) in the treatment group and -1.70±1.55 in the control group (P=0.06). The difference in terms of amplitude of variation of VAS (initial - final VAS) among groups favored the actual procedure (P=0.005). The effect size (ES) for the treatment group was d=1.7, which is considered a large effect. Although small, the statistical power of the sample for these results was very relevant (94.8%). Acupuncture has proven effective in the immediate pain reduction in patients with fibromyalgia, with a quite significant effect size. Copyright © 2014 Elsevier Editora Ltda. All rights reserved.

  14. Complications After Mastectomy and Immediate Breast Reconstruction for Breast Cancer: A Claims-Based Analysis

    Science.gov (United States)

    Jagsi, Reshma; Jiang, Jing; Momoh, Adeyiza O.; Alderman, Amy; Giordano, Sharon H.; Buchholz, Thomas A.; Pierce, Lori J.; Kronowitz, Steven J.; Smith, Benjamin D.

    2016-01-01

    Objective To evaluate complications after post-mastectomy breast reconstruction, particularly in the setting of adjuvant radiotherapy. Summary-Background Data Most studies of complications after breast reconstruction have been conducted at centers of excellence; relatively little is known about complication rates in radiated patients treated in the broader community. This information is relevant for breast cancer patients' decision-making. Methods Using the claims-based MarketScan database, we described complications in 14,894 women undergoing mastectomy for breast cancer from 1998-2007 who received immediate autologous reconstruction (n=2637), immediate implant-based reconstruction (n=3007), or no reconstruction within the first two postoperative years (n=9250). We used a generalized estimating equation to evaluate associations between complications and radiotherapy over time. Results Wound complications were diagnosed within the first two postoperative years in 2.3% of patients without reconstruction, 4.4% with implants, and 9.5% with autologous reconstruction (preconstruction, 20.5% with implants, and 20.7% with autologous reconstruction (preconstruction (OR 1.48, preconstruction (OR=1.55; P=0.01). Conclusions Complication risks after immediate breast reconstruction differ by approach. Radiation therapy appears to modestly increase certain risks, including infection and implant removal. PMID:25876011

  15. Immediate systemic hypersensitivity reaction associated with topical application of Australian tea tree oil.

    Science.gov (United States)

    Mozelsio, Nancy B; Harris, Kathleen E; McGrath, Kris G; Grammer, Leslie C

    2003-01-01

    Australian tea tree oil has been used as a veterinary antiseptic for many years and, more recently, has been extended into human use. There have been many reports of allergic contact dermatitis and toxicity reactions, but it has never been implicated in immediate systemic hypersensitivity reactions. A 38-year-old man experienced immediate flushing, pruritus, throat constriction, and lightheadedness after topical application of tea tree oil. Our purpose was to determine whether this represented an immunoglobulin E (IgE)--mediated reaction. Skin-prick and intradermal testing was performed, as well as enzyme-linked immunosorbent assays for specific IgG and IgE against tea tree oil. The patient had a positive wheal and flare reaction on intradermal testing with tea tree oil. All five patient controls were negative on skin testing. No specific IgG or IgE was detected. We present the first reported case of an immediate systemic hypersensitivity reaction occurring after topical application of Australian tea tree oil, confirmed by positive wheal and flare reaction on skin testing.

  16. Immediate Effects of Mirror Therapy in Patients With Shoulder Pain and Decreased Range of Motion.

    Science.gov (United States)

    Louw, Adriaan; Puentedura, Emilio J; Reese, Dave; Parker, Paula; Miller, Terra; Mintken, Paul E

    2017-05-05

    To determine the effects of a brief single component of the graded motor imagery (GMI) sequence (mirror therapy) on active range of motion (AROM), pain, fear avoidance, and pain catastrophization in patients with shoulder pain. Single-blind case series. Three outpatient physical therapy clinics. Patients with shoulder pain and limited AROM (N=69). Patients moved their unaffected shoulder through comfortable AROM in front of a mirror so that it appeared that they were moving their affected shoulder. We measured pain, pain catastrophization, fear avoidance, and AROM in 69 consecutive patients with shoulder pain and limited AROM before and immediately after mirror therapy. There were significant differences in self-reported pain (P=.014), pain catastrophization (Pmirror therapy; however, the means did not meet or exceed the minimal detectable change (MDC) for each outcome measure. There was a significant increase (mean, 14.5°) in affected shoulder flexion AROM immediately postmirror therapy (Pmirror therapy intervention can result in statistically significant improvements in pain, pain catastrophization, fear avoidance, and shoulder flexion AROM in patients presenting with shoulder pain with limited AROM. The immediate changes may allow a quicker transition to multimodal treatment, including manual therapy and exercise in these patients. Further studies, including randomized controlled trials, are needed to investigate these findings and determine longer-term effects. Copyright © 2017 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  17. Yoga Therapy in Children with Cystic Fibrosis Decreases Immediate Anxiety and Joint Pain

    Directory of Open Access Journals (Sweden)

    Christopher McNamara

    2016-01-01

    Full Text Available This study was designed to determine whether yoga might alleviate symptoms of pain, sleep disturbance, anxiety, and depression in children with cystic fibrosis (CF. CF is the most common genetic, life-limiting chronic disease among Caucasian populations. It primarily affects the lungs but also many other secretory organs and consequently leads to significant morbidities. Research has shown that children with CF have significantly increased depression, anxiety, and pain compared to their healthy counterparts. Subjects participated in six one-on-one sessions over a 10-week period with a certified instructor who designed each yoga practice based on a preestablished list of 30 yoga asanas. Questionnaires evaluating pain, sleep disturbance, sustained anxiety, immediate anxiety, and depression were administered. Differences between premeasures and postmeasures were evaluated using a two-sided test. Twenty subjects were assessed (12 females/8 males, median age of 11 (7–20 years. Mean immediate anxiety scores decreased (before session to after session 29 to 23.6, respectively, p<0.001. Joint pain improved (3.25 to 3.65, p=0.028. CFQ-R emotion subscale improved from 79.2 to 85 (p=0.073, and the respiratory subscale improved from 66.7 to 79.2 (p=0.076. Other results were less notable. We conclude that yoga may reduce immediate anxiety and joint pain in patients with CF.

  18. Cryorecanalization after cryosurgery for immediate treatment on central airway obstruction via flexible bronchoscope

    Institute of Scientific and Technical Information of China (English)

    Yongqun Li; Huasong Feng; Zhoushan Nie; Jiguang Meng; Xinmin Ding; Zhihai Han

    2012-01-01

    Objective: In order to achieve immediate relief of central airway obstruction caused by malignant tumor after interventional therapy, we observed the efficacy and safety of cryorecanalization after cryosurgery via flexible bronchoscope. Methods: A total of 64 cases of patients in all suffered from central airway obstruction were observed and treated by applying cryorecanalization after cryosurgery via flexible bronchoscope. Divide the operation into two steps, including cryosurgery and cryorecanalization. Evaluate the therapeutic effect immediately after the treatment, wherein the evaluating indicator includes preoperative and postoperative dyspnea indexes, quality of life score, bronchoscopy, etc. The surgical safety assessment is mainly by observing the risk of bleeding in the surgery. Results: Forty cases (62.5%) has postoperative dyspnea score improved at least one level compared with preoperative dyspnea score, 24 patients (37.5%) have no significant improvement on dyspnea score. Quality of life score (Karnofsky score): preoperative 52 ± 18.7 points, postoperative 70 ± 9.2 points. Bronchoscopy review: complete success in 12 cases (18.8%), partial success in 45 cases (70.3%), no success in 7 cases (12%).89.1% overall clinical efficiency was achieved. In the surgery, the control to bleeding was satisfactory since no severe bleeding, moderate bleeding in 14 cases (21.9%) and mild bleeding in 50 cases (78.1%) were found as well as rigid bronchoscope was free. Conclusion: The central airway obstruction can be immediately relieved by cryorecanalization after cryosurgery via flexible bronchoscope with satisfactory effects and higher surgical safety.

  19. Skin testing and drug challenge outcomes in antibiotic-allergic patients with immediate-type hypersensitivity.

    Science.gov (United States)

    Mawhirt, Stephanie L; Fonacier, Luz S; Calixte, Rose; Davis-Lorton, Mark; Aquino, Marcella R

    2017-01-01

    The evaluation of antibiotic immediate-type hypersensitivity is intricate because of nonstandardized skin testing and challenge method variability. To determine the safety outcomes and risk factors for antibiotic challenge reactions in patients reporting a history of antibiotic immediate-type hypersensitivity. A 5-year retrospective review of patients evaluated for immediate-type antibiotic allergy was conducted. Data analyzed included patient demographics, index reaction details, and outcomes of skin testing and challenges, classified as single-step or multistep. Antibiotic hypersensitivity history was identified in 211 patients: 78% to penicillins, 10% to fluoroquinolones, 7.6% to cephalosporins, and 3.8% to carbapenems. In total, 179 patients completed the challenges (median age 67 years, range 50-76 years, 56% women), and compared with nonchallenged patients, they reported nonanaphylactic (P antibiotic allergies (P = .005). No correlation was detected between the reported index and observed challenge reaction severities (κ = -0.05, 95% confidence interval -0.34 to 0.24). Anaphylactic rates were similar during single-step and multistep challenges (3.6% vs 3.3%). In the present population, younger women with multiple reported antibiotic allergies were at greatest risk for challenge reactions. Negative skin testing results did not exclude reactions, and index severity was not predictive of challenge outcome. The multistep and full-dose methods demonstrated a comparable reaction risk for anaphylaxis. Copyright © 2016 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  20. Neural signal during immediate reward anticipation in schizophrenia: Relationship to real-world motivation and function

    Directory of Open Access Journals (Sweden)

    Karuna Subramaniam

    2015-01-01

    Full Text Available Amotivation in schizophrenia is a central predictor of poor functioning, and is thought to occur due to deficits in anticipating future rewards, suggesting that impairments in anticipating pleasure can contribute to functional disability in schizophrenia. In healthy comparison (HC participants, reward anticipation is associated with activity in frontal–striatal networks. By contrast, schizophrenia (SZ participants show hypoactivation within these frontal–striatal networks during this motivated anticipatory brain state. Here, we examined neural activation in SZ and HC participants during the anticipatory phase of stimuli that predicted immediate upcoming reward and punishment, and during the feedback/outcome phase, in relation to trait measures of hedonic pleasure and real-world functional capacity. SZ patients showed hypoactivation in ventral striatum during reward anticipation. Additionally, we found distinct differences between HC and SZ groups in their association between reward-related immediate anticipatory neural activity and their reported experience of pleasure. HC participants recruited reward-related regions in striatum that significantly correlated with subjective consummatory pleasure, while SZ patients revealed activation in attention-related regions, such as the IPL, which correlated with consummatory pleasure and functional capacity. These findings may suggest that SZ patients activate compensatory attention processes during anticipation of immediate upcoming rewards, which likely contribute to their functional capacity in daily life.

  1. Disulfiram-loaded immediate and extended release vaginal tablets for the localised treatment of cervical cancer.

    Science.gov (United States)

    Baffoe, Clara S; Nguyen, Nhi; Boyd, Peter; Wang, Weiguang; Morris, Mark; McConville, Christopher

    2015-02-01

    To develop and manufacture both immediate and sustained release vaginal tablets containing the anticancer drug disulfiram, which has the potential to be used as a non-invasive treatment for cervical cancer. Disulfiram-loaded vaginal tablets were manufactured at pilot scale using the direct compression method. These tablets were tested in accordance with the European Pharmacopeia testing of solid dosage form guidelines. They were also tested using a biorelevant dissolution method as well as a dual-chambered release model designed to better mimic the dynamic nature of the vaginal vault. We have developed both immediate and sustained release vaginal tablets, which when manufactured at pilot scale are within the limits set by the European Pharmacopeia for the testing of solid dosage forms. Furthermore, these tablets are capable of releasing disulfiram in vitro using the dual-chambered release model at levels 25,000 times and 35,000 times greater than its IC50 concentration for the HeLa cervical cancer cell line. The successful pilot manufacture and testing of both the immediate and sustained release disulfiram-loaded vaginal tablets warrant further investigation, using an in-vivo model, to assess their potential for use as a non-invasive treatment option for cervical cancer. © 2014 Royal Pharmaceutical Society.

  2. A scaled-up system to evaluate zooplankton spatial avoidance and the population immediate decline concentration.

    Science.gov (United States)

    Rosa, Rita; Materatski, Patrick; Moreira-Santos, Matilde; Sousa, José Paulo; Ribeiro, Rui

    2012-06-01

    Most laboratory tests may underestimate adverse effects in real scenarios of contamination because they imply the forced exposure of organisms to contaminants, thus overlooking the possibility of emigration. Avoidance from contaminants has been observed in several aquatic organisms, and avoidance-based tests have been recommended to be included in risk assessment studies. To reduce uncertainty in the extrapolation of laboratory derived results, the first aim of the present study was to compare both the median avoidance concentration and the lowest-observed-effect gradient (LOEG) values of atrazine for the cladoceran Daphnia magna, between an already developed 1.1-m-long system and a scaled-up system, three times longer. Second, the present study aimed at evaluating the population immediate decline--the proportion of the population that disappears (avoids and, if not, dies)--through the integration of the relationships between lethality and avoidance versus contaminant concentration. Daphnia magna significantly avoided atrazine, during 12-h exposures, with similar results in the original and scaled-up systems. The population immediate decline at the 48-h median lethal concentration would be 94%. Even at a concentration eliciting only 5% mortality, the population immediate decline would be over 50%. Achieving a higher pertinence of avoidance results and a better understanding of the LOEG values and their time dependence, scaling up the system further both spatially and temporally, and modeling explicit spatial dynamics in exposure and organism movement in space and time are needed.

  3. Immediate effect of percutaneous intramuscular stimulation during gait in children with cerebral palsy: a feasibility study.

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    Orlin, Margo N; Pierce, Samuel R; Stackhouse, Carrie Laughton; Smith, Brian T; Johnston, Therese; Shewokis, Patricia A; McCarthy, James J

    2005-10-01

    The feasibility of percutaneous intramuscular functional electrical stimulation (P-FES) in children with cerebral palsy (CP) for immediate improvement of ankle kinematics during gait has not previously been reported. Eight children with CP (six with diplegia, two with hemiplegia; mean age 9 years 1 month [SD 1 y 4 mo; range 7 y 11 mo to 11 y 10 mo]) had percutaneous intramuscular electrodes implanted into the gastrocnemius (GA) and tibialis anterior (TA) muscles of their involved limbs. Stimulation was provided during appropriate phases of the gait cycle in three conditions (GA only, TA only, and GA/TA). immediately after a week of practice for each stimulation condition, a gait analysis was performed with and without stimulation. A significant improvement in peak dorsiflexion in swing for the more affected extremity and dorsiflexion at initial contact for the less affected extremity were found in the GA/TA condition. Clinically meaningful trends were evident for improvements in dorsiflexion kinematics for the more and less affected extremities in the TA only and GA/TA conditions. The results suggest that P-FES might immediately improve ankle kinematics in children with CP.

  4. Neural signal during immediate reward anticipation in schizophrenia: Relationship to real-world motivation and function.

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    Subramaniam, Karuna; Hooker, Christine I; Biagianti, Bruno; Fisher, Melissa; Nagarajan, Srikantan; Vinogradov, Sophia

    2015-01-01

    Amotivation in schizophrenia is a central predictor of poor functioning, and is thought to occur due to deficits in anticipating future rewards, suggesting that impairments in anticipating pleasure can contribute to functional disability in schizophrenia. In healthy comparison (HC) participants, reward anticipation is associated with activity in frontal-striatal networks. By contrast, schizophrenia (SZ) participants show hypoactivation within these frontal-striatal networks during this motivated anticipatory brain state. Here, we examined neural activation in SZ and HC participants during the anticipatory phase of stimuli that predicted immediate upcoming reward and punishment, and during the feedback/outcome phase, in relation to trait measures of hedonic pleasure and real-world functional capacity. SZ patients showed hypoactivation in ventral striatum during reward anticipation. Additionally, we found distinct differences between HC and SZ groups in their association between reward-related immediate anticipatory neural activity and their reported experience of pleasure. HC participants recruited reward-related regions in striatum that significantly correlated with subjective consummatory pleasure, while SZ patients revealed activation in attention-related regions, such as the IPL, which correlated with consummatory pleasure and functional capacity. These findings may suggest that SZ patients activate compensatory attention processes during anticipation of immediate upcoming rewards, which likely contribute to their functional capacity in daily life.

  5. [Evaluation of immediate post-operative pain in heart surgery using the Behavioural Pain Scale].

    Science.gov (United States)

    Pozas Abril, J; Toraño Olivera, M J; Latorre-Marco, I

    2014-01-01

    Patients in the immediate postoperative period of cardiac surgery have abolished communication skills and therefore can not express pain. Pain produces significant adverse effects that alter the patients' course. Therefore, identifying and controlling them will lead to increased quality of care for the critical patient. To measure the degree of pain in patients in the immediate postoperative period of cardiac surgery by scaling Behavioural Pain Scale. An observational, prospective and longitudinal. Patients over 18 years in the first 24 hours of admission with no communication problems who were under sedation and subjected to mechanical ventilation were included. Twenty patients were enrolled in the study. The Behavioural Pain Scale (BPS) was used during two procedures usually considered as a painful practice in the literature, that is, mobilization and/or postural changes and aspiration of secretions. Twenty-seven measurements were made of procedures considered as painful. The results obtained by applying the scale BPS showed that 70.4% of patients had no pain, 22.2% had mild to moderate pain and 7.4% had unacceptable pain. This study has identified that the patients suffer pain during the postoperative period. Within these patients, there is a small, but not insignificant number whose pain is unacceptable during this period. This finding serves as a beginning for a line of research to improve the handling of the postoperative pain during immediate post-operative cardiac surgery. Copyright © 2013 Elsevier España, S.L. y SEEIUC. All rights reserved.

  6. [Atraumatic bone expansion: Interest of piezo-surgery, conicals expanders and immediate implantation combination].

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    Iraqui, O; Lakhssassi, N; Berrada, S; Merzouk, N

    2016-06-01

    The durability of dental implants depends on the presence of a 1mm coating bone sheath all around the fixture. Therefore, bone resorption represents a challenge for the practitioner. Bone expansion is a surgical technique that allows the management of horizontal bone atrophy. Cortical bone splitting allows for an enlargement of the residual crest by displacement of the vestibular bone flap. The immediate placement of implants secures the widening and allows for a 97% survival rate. However, bone expansion is hard to undertake in sites with high bone density. Furthermore, the use of traditional instruments increases patient's stress and the risk for an interruptive fracture during bone displacement. Non-traumatic bone expansion is one solution to this problem. The combination of piezo-surgery and conical expanders allows for a secured displacement of the selected bone flap as well as an immediate implant placement, avoiding the risk of slipping, overheating, or fracture, all within an undeniable operative comfort. Non-traumatic bone expansion is a reliable, reproducible, conservative, and economical in time and cost procedure. We describe our atraumatic bone expension and immediate implant placement technique in high bone density sites and illustrate it by a clinical case.

  7. Immediate primary anastomosis for isolated oesophageal atresia: A single-centre experience

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    Ibrahim Uygun

    2015-01-01

    Full Text Available Background: Isolated oesophageal atresia without tracheo-oesophageal fistula represents a major challenge for most paediatric surgeons. Here, we present our experience with six neonates with isolated oesophageal atresia who successfully underwent immediate primary anastomosis using multiple Livaditis circular myotomy. Materials and Methods: All six neonates were gross type A isolated oesophageal atresia (6%, from among 102 neonates with oesophageal atresia, treated between January 2009 and December 2013. Five neonates were female; one was male. The mean birth weight was 2300 (range 1700-3100 g. Results: All six neonates successfully underwent immediate primary anastomosis using multiple myotomies (mean 3; range 2-4 within 10 (median 3 days after birth. The gap under traction ranged from 6 to 7 cm. One neonate died of a major cardiac anomaly. Another neonate was lost to follow-up after being well for 3 months. Three anastomotic strictures were treated with balloon dilatation, and four anastomotic leaks were treated conservatively. The mean duration of follow-up was 33 months. Conclusions: To treat isolated oesophageal atresia, an immediate primary anastomosis can be achieved using multiple myotomies. Although, this approach is associated with high complication rates, as are other similar approaches, these complications can be overcome.

  8. Effects of computer-based immediate feedback on foreign language listening comprehension and test-associated anxiety.

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    Lee, Shu-Ping; Su, Hui-Kai; Lee, Shin-Da

    2012-06-01

    This study investigated the effects of immediate feedback on computer-based foreign language listening comprehension tests and on intrapersonal test-associated anxiety in 72 English major college students at a Taiwanese University. Foreign language listening comprehension of computer-based tests designed by MOODLE, a dynamic e-learning environment, with or without immediate feedback together with the state-trait anxiety inventory (STAI) were tested and repeated after one week. The analysis indicated that immediate feedback during testing caused significantly higher anxiety and resulted in significantly higher listening scores than in the control group, which had no feedback. However, repeated feedback did not affect the test anxiety and listening scores. Computer-based immediate feedback did not lower debilitating effects of anxiety but enhanced students' intrapersonal eustress-like anxiety and probably improved their attention during listening tests. Computer-based tests with immediate feedback might help foreign language learners to increase attention in foreign language listening comprehension.

  9. Body Posture After Mastectomy: Comparison Between Immediate Breast Reconstruction Versus Mastectomy Alone.

    Science.gov (United States)

    Atanes Mendes Peres, Ana Carolina; Dias de Oliveira Latorre, Maria do Rosário; Yugo Maesaka, Jonathan; Filassi, José Roberto; Chada Baracat, Edmund; Alves Gonçalves Ferreira, Elizabeth

    2017-01-01

    Immediate breast reconstruction has been increasingly incorporated as part of breast cancer treatment, especially for the psychological benefits. Currently, there are many options for breast reconstruction surgery, but the impact of the different techniques on body posture has not been widely studied. One study demonstrated that immediate breast reconstruction with a Beker-25 prosthesis could help to preserve body posture after mastectomy; however, there is no evidence regarding the effect of surgery on the body posture of women after breast reconstruction when using autologous tissue. The purpose of this paper is to compare the body postures of women who underwent immediate breast reconstruction using an abdominal flap with those of women who underwent mastectomy alone. This is a cross-sectional study. Seventy-six women diagnosed with breast cancer underwent mastectomy, between 1 and 5 years after the diagnosis, are the participants of the study. Two groups were defined: women who underwent mastectomy and immediate breast reconstruction (n = 38) and women who underwent mastectomy alone (n = 38). To assess body posture, specific anatomical points for obtaining photographs were located and marked in anterior, posterior and right-side and left-side views. The photographs were analysed using Postural Analysis Software/Software de Análise Postural (PAS/SAPO). In the left lateral view, there was a significant difference in the vertical alignment of the trunk (4.2 vs 3.1; p = 0.05). There were no significant differences between the two groups for the variables in the anterior, posterior or right-side views. Women who underwent mastectomy alone, compared with women who underwent immediate breast reconstruction with abdominal flaps, showed differences in the vertical alignment of the trunk, with greater asymmetry between the acromion and greater trochanter, which can mean trunk rotation. No significant differences were found between the two groups in the

  10. Immediate vs delayed repair bond strength of a nanohybrid resin composite.

    Science.gov (United States)

    El-Askary, Farid S; El-Banna, Ahmed H; van Noort, Richard

    2012-06-01

    To evaluate both the immediate and water-stored repair tensile bond strength (TBS) of a nanohybrid resin composite using different bonding protocols. One hundred sixty half hourglass-shaped slabs were prepared. Eighty half-slabs were wet ground immediately after light curing using high-speed abrasive burs, while the other half-slabs were stored in water for one month (delayed) and then wet ground for repair. Each set of the 80 repaired slabs was split into two groups to be tested for TBS after 24 h or 1 month of water storage. For all repaired slabs, either immediate or delayed, four bonding procedures were used involving wet and dry bonding with a 3-step etch-and-rinse adhesive with or without silane pretreatment. TBS tests were performed at a crosshead speed of 0.5 mm/min. To determine the cohesive strength of the resin composite itself, which served as the reference, additional whole slabs were prepared and tested in tension after a 24-h (n = 10) and a 1-month storage period (n = 10). Failure modes were evaluated using a stereomicroscope at 40X magnification. Three-way ANOVA was run to test the effect of water storage, testing time, bonding protocols, and their interactions on the repair TBS, which was given as a percentage of the reference values. For the immediate repair groups, the repair TBS ranged from 40% to 61.9% after 24-h storage and from 26% to 53.1% after 1-month water storage compared to the TBS of the whole slabs. For the delayed repair group, the repaired TBS ranged from 47.2% to 63.6% for the 24-h repairs and from 32.2% to 44.2% for the test groups stored in water for 1 month. Three-way ANOVA revealed that water storage had no significant effect on the repair TBS (p = 0.619). Both testing time and bonding protocols had a significant effect on the repair TBS (p = 0.001). The interactions between the independent variables (water storage, testing time, and bonding protocols) had no significant effect (p = 0.067). The repair bond strength was

  11. Nucleotide sequence of an immediate-early frog virus 3 gene.

    Science.gov (United States)

    Willis, D; Foglesong, D; Granoff, A

    1984-12-01

    We have used "gene walking" with synthetic oligonucleotides and M13 dideoxynucleotide sequencing techniques to obtain the complete coding and flanking sequences of the gene encoding a major immediate-early RNA (molecular weight, 169,000) of frog virus 3. R-loop mapping of the cloned XbaI K fragment of frog virus 3 DNA with immediate-early RNA from infected cells showed that an RNA of approximately 500 to 600 nucleotides (the right size to code for the immediate-early viral 18-kilodalton protein of unknown function) hybridized to a region within 100 base pairs of one end of the XbaI K fragment; no evidence for splicing was observed in the electron microscope or by single-strand nuclease analysis. Further restriction mapping narrowed the location of the gene to the XbaI end of a 2-kilobase-pair XbaI-Bg/II fragment, which was bidirectionally subcloned into the bacteriophage pair mp10 and mp11 for sequencing. Mung bean nuclease mapping was used to identify both the 5' and the 3' ends of the mRNA. The 5' end mapped within an AT-rich region 19 base pairs upstream from two in-phase AUG start codons that were immediately followed by an open reading frame of 157 amino acids. Another AT-rich sequence was found at -29 base pairs from the 5' end of the mRNA start site; this sequence may function as a TATA box. The 3' end of the message displayed considerable microheterogeneity, but clearly terminated within a third AT-rich region 50 to 60 base pairs from the translation stop codon. The eucaryotic polyadenylic acid addition signal (AATAAA) was not present, a finding to be expected since frog virus 3 mRNA is not polyadenylated. Both the single-stranded mp10 clone of the XbaI-Bg/II fragment and a 15-base oligonucleotide complementary to the region flanking the two AUG translation start codons inhibited translation of the immediate-early 18-kilodalton protein in vitro, confirming the identity of the sequenced gene. As the regulatory sequences of this gene did not resemble those of

  12. Immediate-release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults.

    Science.gov (United States)

    Epstein, Tamir; Patsopoulos, Nikolaos A; Weiser, Mark

    2014-09-18

    Symptoms of attention deficit hyperactivity disorder (ADHD), diagnosed mainly in children, often persist into adulthood. Adults in this group have a high rate of other psychiatric problems and functional difficulties in a number of key areas such as academic achievement, interpersonal relationships, and employment. Although the usefulness of immediate-release methylphenidate in children has been extensively studied, studies in adults, which are few, demonstrate varying results. To evaluate the efficacy and tolerability of immediate-release methylphenidate versus placebo in the treatment of adults with ADHD. We searched the following databases in November 2013: CENTRAL, Ovid MEDLINE, EMBASE, PsycINFO, Database of Abstracts of Reviews of Effects (DARE), and two trials registers. Biosis was searched in December 2013. We inspected references of all relevant papers to identify more studies and contacted authors of recently published trials. We included all randomized trials comparing immediate-release methylphenidate versus placebo in participants aged 18 years or older with ADHD. We excluded trials conducted on subpopulations of adults with ADHD such as adults with both ADHD and substance dependence. Two review authors independently selected trials, extracted data, and assessed trial risk of bias. We contacted authors of trials to ask for additional and missing data. For dichotomous outcomes, we calculated risk ratios (RRs) and 95% confidence intervals (CIs). For continuous outcomes, we calculated mean differences (MDs) or standardized mean differences (SMDs) with 95% CIs. Results from the 11 randomized controlled trials (474 participants, counting participants from cross-over studies as a single arm, and counting both arms from parallel studies) included in the review demonstrated improvement in core clinical ADHD symptoms of hyperactivity, impulsivity, and inattentiveness, and overall improvement. We were able to pool results from 10 studies, which included 466

  13. Immediate versus deferred delivery of the preterm baby with suspected fetal compromise for improving outcomes.

    Science.gov (United States)

    Stock, Sarah J; Bricker, Leanne; Norman, Jane E; West, Helen M

    2016-07-12

    Immediate delivery of the preterm fetus with suspected compromise may decrease the risk of damage due to intrauterine hypoxia. However, it may also increase the risks of prematurity. To assess the effects of immediate versus deferred delivery of preterm babies with suspected fetal compromise on neonatal, maternal and long-term outcomes. We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 April 2016) and reference lists of retrieved studies. Randomised trials comparing a policy of immediate delivery with deferred delivery or expectant management in preterm fetuses with suspected in utero compromise. Quasi-randomised trials and trials employing a cluster-randomised design were eligible for inclusion but none were identified. Two review authors independently assessed trials for inclusion and risk of bias, extracted data and checked them for accuracy. We included one trial of 548 women (588 babies) in the review. Women with pregnancies between 24 and 36 weeks' gestation took part. The study took place in 13 European countries, between 1993 and 2001. The difference in the median randomisation to delivery interval between immediate delivery and deferred delivery was four days (median: 0.9 (inter-quartile range (IQR) 0.4 to 1.3) days for immediate delivery, median: 4.9 (IQR 2.0 to 10.8) days in the delay group).There was no clear difference in the primary outcomes of extended perinatal mortality (risk ratio (RR) 1.17, 95% confidence interval (CI) 0.67 to 2.04, one trial, 587 babies, moderate-quality evidence) or the composite outcome of death or disability at or after two years of age (RR 1.22, 95% CI 0.85 to 1.75, one trial, 573 babies, moderate-quality evidence) with immediate delivery compared to deferred delivery. The results for these outcomes are consistent with both appreciable benefit and harm. More babies in the immediate delivery group were ventilated for more than 24 hours (RR 1.54, 95% CI 1.20 to 1.97, one trial, 576 babies). There

  14. Single- and multiple-dose pharmacokinetics of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (MNK-155 compared with immediate-release hydrocodone bitartrate/ibuprofen and immediate-release tramadol HCl/acetaminophen

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    Devarakonda K

    2015-09-01

    Full Text Available Krishna Devarakonda,1 Kenneth Kostenbader,2 Michael J Giuliani,3 Jim L Young41Department of Clinical Pharmacology, Mallinckrodt Pharmaceuticals, 2Mallinckrodt Pharmaceuticals, 3Research and Development, Mallinckrodt Pharmaceuticals, 4Department of Clinical Affairs and Program Management, Mallinckrodt Pharmaceuticals, Hazelwood, MO, USAObjective: To characterize the single-dose and steady-state pharmacokinetics (PK of biphasic immediate-release/extended-release hydrocodone bitartrate/acetaminophen (IR/ER HB/APAP, IR HB/ibuprofen, and IR tramadol HCl/APAP.Methods: In this single-center, open-label, randomized, four-period crossover study, healthy participants received four treatments under fasted conditions: 1 a single dose of two IR/ER HB/APAP 7.5/325 mg tablets (15/650 mg total dose on day 1, followed by two tablets every 12 hours (q12h beginning on day 3; 2 a single dose of IR HB/ibuprofen 15/400 mg (divided as one 7.5/200 mg tablet at hour 0 and 6, followed by one tablet every 6 hours (q6h beginning on day 3; 3 a single dose of IR tramadol HCl/APAP 75/650 mg (divided as one 37.5/325 mg tablet at hour 0 and 6, followed by one tablet q6h beginning on day 3; and 4 a single dose of three IR/ER HB/APAP 7.5/325 mg tablets (22.5/975 mg total dose on day 1, a three-tablet initial dose at 48 hours followed by two-tablet doses q12h beginning on day 3. Hydrocodone and APAP single-dose and steady-state PK were assessed. Adverse events were monitored.Results: The PK analysis was carried out on 29 of 48 enrolled participants who completed all treatment periods. Single-dose hydrocodone exposure was similar for IR/ER HB/APAP 22.5/975 mg and IR HB/ibuprofen 15/400 mg; time to maximum observed plasma concentration was shorter and half-life was longer for IR/ER HB/APAP (22.5/975 mg and 15/650 mg vs IR HB/ibuprofen. Single-dose APAP exposure was similar for IR/ER HB/APAP 15/650 mg and IR tramadol HCl/APAP 75/650 mg. Steady-state hydrocodone and APAP exposures

  15. Diagnostic yield of a biopsy performed immediately after lung radiofrequency ablation.

    Science.gov (United States)

    Tselikas, Lambros; de Baere, Thierry; Deschamps, Frederic; Hakimé, Antoine; Besse, Benjamin; Teriitehau, Christophe; de Montpreville, Vincent; Adam, Julien

    2017-03-01

    To evaluate the diagnostic performance of lung biopsies performed immediately after radiofrequency ablation (RFA). Twenty consecutive patients were treated with lung RFA. A biopsy was performed immediately after RFA, through the cannula used to insert the RFA probe to avoid hampering the RFA probe placement. Biopsies were analysed for diagnostic of malignancy and tumour morphological characteristics. Recurrence of RFA and procedure-related complications are reported. Mean tumour size was 17.3 mm (±6.2 mm). Ninety per cent (18/20) of biopsies were able to help diagnose malignancy. Cancer subtype and origin were determined in 70 % (14/20) of tumours, including 12 metastases and two primary lung cancers. During a median follow-up of 24 months, one tumour demonstrated local progression (5 %). The overall survival, lung disease-free survival and progression-free survival rates at 12 months were 100 %, 75 % and 65 %, respectively. Adverse events of the procedure including RFA and biopsy were five pneumothoraces requiring chest tube placement (25 %), seven minor pneumothoraces (35 %) and one subsegmental intrapulmonary haemorrhage (5 %) not requiring any treatment. A biopsy performed immediately after lung RFA allowed diagnosis of malignancy in 90 % of cases. This diagnosis is obtained without the need for additional puncture and does not hamper the accuracy of the initial RF probe placement. • Treatment and biopsy are feasible during the same procedure, avoiding multiple punctures. • The best puncture path can be preserved to treat the lung tumour. • Malignancy can be determined on a post-RFA biopsy in 90 % of cases. • Cancer classification can be assessed in 70 % of cases after lung RFA.

  16. Immediate and short-term pain relief by acute sciatic nerve press: a randomized controlled trial

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    Zhang Wenlong

    2007-05-01

    Full Text Available Abstract Background Despite much research, an immediately available, instantly effective and harmless pain relief technique has not been discovered. This study describes a new manipulation: a "2-minute sciatic nerve press", for rapid short-term relief of pain brought on by various dental and renal diseases. Methods This randomized, single-blind, placebo-controlled trial ran in three hospitals in Anhui Province, China, with an enrollment of 66 out of 111 solicited patients aged 16 to 74 years. Patients were recruited sequentially, by specific participating physicians at their clinic visits to three independent hospitals. The diseases in enrolled dental patients included dental caries, periodontal diseases and dental trauma. Renal diseases in recruits included kidney infections, stones and some other conditions. Patients were randomly assigned to receive the "2-minute sciatic nerve press" or the "placebo press". For the "2-minute sciatic nerve press", pressure was applied simultaneously to the sciatic nerves at the back of the thighs, using the fists while patients lay prone. For the "placebo press", pressure was applied simultaneously to a parallel spot on the front of the thighs, using the fists while patients lay supine. Each fist applied a pressure of 11 to 20 kg for 2 minutes, after which, patients arose to rate pain. Results The "2-minute sciatic nerve press" produced greater pain relief than the "placebo press". Within the first 10 minutes after sciatic pressure, immediate pain relief ratings averaged 66.4% (p Conclusion Two minutes of pressure on both sciatic nerves can produce immediate significant conduction analgesia, providing a convenient, safe and powerful way to overcome clinical pain brought on by dental diseases and renal diseases for short term purposes. Trial registration ACTR 12606000439549

  17. Immediate and late management of iatrogenic ureteric injuries: 28 years of experience

    Science.gov (United States)

    El Abd, Ahmed S.; El-Abd, Shawky A.; El-Enen, Mohamed Abo; Tawfik, Ahmed M.; Soliman, Mohamed G.; Abo-Farha, Mohamed; Gamasy, Abd-El Naser El; El-Sharaby, Mahmoud; El-Gamal, Samir

    2015-01-01

    Objective To evaluate the long-term results after managing intraoperative and late-diagnosed cases of iatrogenic ureteric injury (IUI), treated endoscopically or by open surgery. Patients and methods Patients immediately diagnosed with IUI were managed under the same anaesthetic, while those referred late had a radiological assessment of the site of injury, and endoscopic management. Open surgical procedures were used only for the failed cases with previous diversion. Results In all, 98 patients who were followed had IUI after gynaecological, abdominopelvic and ureteroscopic procedures in 60.2%, 14.3% and 25.5%, respectively. The 27 patients diagnosed during surgery were managed immediately, while in the late-referred 71 patients ureteroscopic ureteric realignment with stenting was successful in 26 (36.6%). Complex open reconstruction with re-implantation or ureteric substitution, using bladder-tube or intestinal-loop procedures, was used in 27 (60%), 16 (35.5%) and two (4.5%) patients of the late group, respectively. A long-term radiological follow-up with a mean (range) of 46.6 (24.5–144) months showed recurrent obstruction in 16 (16.3%) patients managed endoscopically and reflux in six (8.3%) patients. Three renal units only (3%) were lost in the late-presenting patients. Conclusion Patients managed immediately had better long-term results. More than a third of the late-diagnosed patients were successfully managed endoscopically with minimal morbidity. Open reconstruction by an experienced urologist who can perform a complex substitutional procedure was mandatory to preserve renal units in the long-term. PMID:26609443

  18. Choice between delayed food and immediate opioids in rats: treatment effects and individual differences.

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    Panlilio, Leigh V; Secci, Maria E; Schindler, Charles W; Bradberry, Charles W

    2017-09-04

    Addiction involves maladaptive choice behavior in which immediate drug effects are valued more than delayed nondrug rewards. To model this behavior and extend our earlier work with the prescription opioid oxycodone, we allowed rats to choose between immediate intravenous delivery of the short-acting opioid remifentanil and delayed delivery of highly palatable food pellets. Treatment drugs were tested on a baseline where remifentanil was preferred over food. Treatment with a high dose of the opioid antagonist naltrexone decreased but did not reverse the preference for remifentanil. Treatment with the serotonin 5-HT2C agonist lorcaserin decreased remifentanil and food self-administration nonselectively. Across conditions in which the alternative to delayed food was either a moderate dose of oxycodone, a moderate or high dose of remifentanil, a smaller more immediate delivery of food, or timeout with no primary reinforcement, choice was determined by both the length of the delay and the nature of the alternative option. Delayed food was discounted most steeply when the alternative was a high dose of remifentanil, which was preferred over food when food was delayed by 30 s or more. Within-subject comparisons showed no evidence for trait-like impulsivity or sensitivity to delay across these conditions. Choice was determined more by the current contingencies of reinforcement than by innate individual differences. This finding suggests that people might develop steep delay-discounting functions because of the contingencies in their environment, and it supports the use of contingency management to enhance the relative value of delayed nondrug reinforcers.

  19. Immediate effect of transcutaneous electrical nerve stimulation on spasticity in patients with spinal cord injury.

    Science.gov (United States)

    Ping Ho Chung, Bryan; Kam Kwan Cheng, Benson

    2010-03-01

    To investigate the immediate effect of transcutaneous electrical nerve stimulation (TENS) on spasticity in patients with spinal cord injury. Randomized controlled trial. Extended rehabilitation centre. Eighteen subjects with spinal cord injury and symptoms of spasticity over lower limbs were randomly assigned to receive either 60 minutes of active TENS (0.25 ms, 100 Hz, 15 mA) or 60 minutes of placebo non-electrically stimulated TENS over the common peroneal nerve. Composite Spasticity Score was used to assess the spasticity level of ankle plantar flexors immediately before and after TENS application. Composite Spasticity Score consisted of Achilles tendon jerks, resistance to full-range passive ankle dorsiflexion and ankle clonus. Between-group statistical differences of reduction of Composite Spasticity Score, Achilles tendon jerks, resistance to full-range passive ankle dorsiflexion and ankle clonus were calculated using the Mann-Whitney test. Within-group statistical differences of Composite Spasticity Score, Achilles tendon jerks, resistance to full-range passive ankle dorsiflexion and ankle clonus were calculated using the Wilcoxon signed ranks test. Significant reductions were shown in Composite Spasticity Score by 29.5% (p = 0.017), resistance to full-range passive ankle dorsiflexion by 31.0% (p = 0.024) and ankle clonus by 29.6% (p = 0.023) in the TENS group but these reductions were not found in the placebo TENS group. The between-group differences of both Composite Spasticity Score and resistance to full-range passive ankle dorsiflexion were significant (p = 0.027 and p = 0.024, respectively). This study showed that a single session of TENS could immediately reduce spasticity.

  20. Nipple-Areola Complex Necrosis after Nipple-Sparing Mastectomy with Immediate Autologous Breast Reconstruction

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    Jin-Woo Cho

    2015-09-01

    Full Text Available BackgroundAutologous or implant-based breast reconstruction after nipple-sparing mastectomy is increasingly preferred worldwide as a breast cancer treatment option. However, postoperative nipple-areola complex (NAC necrosis is the most significant complication of nipple-sparing mastectomy. The purpose of our study was to identify the risk factors for NAC necrosis, and to describe the use of our skin-banking technique as a solution.MethodsWe reviewed cases of immediate autologous breast reconstruction after nipple-sparing mastectomy at our institution between June 2005 and January 2014. The patients' data were reviewed and the risk of NAC necrosis was analyzed based on correlations between patient variables and NAC necrosis. Moreover, data pertaining to five high-risk patients who underwent the donor skin-banking procedure were included in the analysis.ResultsEighty-five patients underwent immediate autologous breast reconstruction after nipple-sparing mastectomy during the study period. Partial or total NAC necrosis occurred in 36 patients (43.4%. Univariate analysis and binary regression modeling found that body mass index, smoking history, radiation therapy, and mastectomy volume were significantly associated with NAC necrosis. Of the 36 cases of NAC necrosis, 31 were resolved with dressing changes, debridement, or skin grafting. The other five high-risk patients underwent our prophylactic skin-banking technique during breast reconstruction surgery.ConclusionsNAC necrosis is common in patients with multiple risk factors. The use of the skin-banking technique in immediate autologous breast reconstruction is an attractive option for high-risk patients. Banked skin can be used in such cases without requiring additional donor tissue, with good results in terms of aesthetic and reconstructive outcomes.