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Sample records for poisson generalized linear

  1. Evaluating the double Poisson generalized linear model.

    Science.gov (United States)

    Zou, Yaotian; Geedipally, Srinivas Reddy; Lord, Dominique

    2013-10-01

    The objectives of this study are to: (1) examine the applicability of the double Poisson (DP) generalized linear model (GLM) for analyzing motor vehicle crash data characterized by over- and under-dispersion and (2) compare the performance of the DP GLM with the Conway-Maxwell-Poisson (COM-Poisson) GLM in terms of goodness-of-fit and theoretical soundness. The DP distribution has seldom been investigated and applied since its first introduction two decades ago. The hurdle for applying the DP is related to its normalizing constant (or multiplicative constant) which is not available in closed form. This study proposed a new method to approximate the normalizing constant of the DP with high accuracy and reliability. The DP GLM and COM-Poisson GLM were developed using two observed over-dispersed datasets and one observed under-dispersed dataset. The modeling results indicate that the DP GLM with its normalizing constant approximated by the new method can handle crash data characterized by over- and under-dispersion. Its performance is comparable to the COM-Poisson GLM in terms of goodness-of-fit (GOF), although COM-Poisson GLM provides a slightly better fit. For the over-dispersed data, the DP GLM performs similar to the NB GLM. Considering the fact that the DP GLM can be easily estimated with inexpensive computation and that it is simpler to interpret coefficients, it offers a flexible and efficient alternative for researchers to model count data. Copyright © 2013 Elsevier Ltd. All rights reserved.

  2. Double generalized linear compound poisson models to insurance claims data

    DEFF Research Database (Denmark)

    Andersen, Daniel Arnfeldt; Bonat, Wagner Hugo

    2017-01-01

    This paper describes the specification, estimation and comparison of double generalized linear compound Poisson models based on the likelihood paradigm. The models are motivated by insurance applications, where the distribution of the response variable is composed by a degenerate distribution...... in a finite sample framework. The simulation studies are also used to validate the fitting algorithms and check the computational implementation. Furthermore, we investigate the impact of an unsuitable choice for the response variable distribution on both mean and dispersion parameter estimates. We provide R...... implementation and illustrate the application of double generalized linear compound Poisson models using a data set about car insurances....

  3. Application of the Hyper-Poisson Generalized Linear Model for Analyzing Motor Vehicle Crashes.

    Science.gov (United States)

    Khazraee, S Hadi; Sáez-Castillo, Antonio Jose; Geedipally, Srinivas Reddy; Lord, Dominique

    2015-05-01

    The hyper-Poisson distribution can handle both over- and underdispersion, and its generalized linear model formulation allows the dispersion of the distribution to be observation-specific and dependent on model covariates. This study's objective is to examine the potential applicability of a newly proposed generalized linear model framework for the hyper-Poisson distribution in analyzing motor vehicle crash count data. The hyper-Poisson generalized linear model was first fitted to intersection crash data from Toronto, characterized by overdispersion, and then to crash data from railway-highway crossings in Korea, characterized by underdispersion. The results of this study are promising. When fitted to the Toronto data set, the goodness-of-fit measures indicated that the hyper-Poisson model with a variable dispersion parameter provided a statistical fit as good as the traditional negative binomial model. The hyper-Poisson model was also successful in handling the underdispersed data from Korea; the model performed as well as the gamma probability model and the Conway-Maxwell-Poisson model previously developed for the same data set. The advantages of the hyper-Poisson model studied in this article are noteworthy. Unlike the negative binomial model, which has difficulties in handling underdispersed data, the hyper-Poisson model can handle both over- and underdispersed crash data. Although not a major issue for the Conway-Maxwell-Poisson model, the effect of each variable on the expected mean of crashes is easily interpretable in the case of this new model. © 2014 Society for Risk Analysis.

  4. Characterizing the performance of the Conway-Maxwell Poisson generalized linear model.

    Science.gov (United States)

    Francis, Royce A; Geedipally, Srinivas Reddy; Guikema, Seth D; Dhavala, Soma Sekhar; Lord, Dominique; LaRocca, Sarah

    2012-01-01

    Count data are pervasive in many areas of risk analysis; deaths, adverse health outcomes, infrastructure system failures, and traffic accidents are all recorded as count events, for example. Risk analysts often wish to estimate the probability distribution for the number of discrete events as part of doing a risk assessment. Traditional count data regression models of the type often used in risk assessment for this problem suffer from limitations due to the assumed variance structure. A more flexible model based on the Conway-Maxwell Poisson (COM-Poisson) distribution was recently proposed, a model that has the potential to overcome the limitations of the traditional model. However, the statistical performance of this new model has not yet been fully characterized. This article assesses the performance of a maximum likelihood estimation method for fitting the COM-Poisson generalized linear model (GLM). The objectives of this article are to (1) characterize the parameter estimation accuracy of the MLE implementation of the COM-Poisson GLM, and (2) estimate the prediction accuracy of the COM-Poisson GLM using simulated data sets. The results of the study indicate that the COM-Poisson GLM is flexible enough to model under-, equi-, and overdispersed data sets with different sample mean values. The results also show that the COM-Poisson GLM yields accurate parameter estimates. The COM-Poisson GLM provides a promising and flexible approach for performing count data regression. © 2011 Society for Risk Analysis.

  5. Log-normal frailty models fitted as Poisson generalized linear mixed models.

    Science.gov (United States)

    Hirsch, Katharina; Wienke, Andreas; Kuss, Oliver

    2016-12-01

    The equivalence of a survival model with a piecewise constant baseline hazard function and a Poisson regression model has been known since decades. As shown in recent studies, this equivalence carries over to clustered survival data: A frailty model with a log-normal frailty term can be interpreted and estimated as a generalized linear mixed model with a binary response, a Poisson likelihood, and a specific offset. Proceeding this way, statistical theory and software for generalized linear mixed models are readily available for fitting frailty models. This gain in flexibility comes at the small price of (1) having to fix the number of pieces for the baseline hazard in advance and (2) having to "explode" the data set by the number of pieces. In this paper we extend the simulations of former studies by using a more realistic baseline hazard (Gompertz) and by comparing the model under consideration with competing models. Furthermore, the SAS macro %PCFrailty is introduced to apply the Poisson generalized linear mixed approach to frailty models. The simulations show good results for the shared frailty model. Our new %PCFrailty macro provides proper estimates, especially in case of 4 events per piece. The suggested Poisson generalized linear mixed approach for log-normal frailty models based on the %PCFrailty macro provides several advantages in the analysis of clustered survival data with respect to more flexible modelling of fixed and random effects, exact (in the sense of non-approximate) maximum likelihood estimation, and standard errors and different types of confidence intervals for all variance parameters. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  6. Accuracy assessment of the linear Poisson-Boltzmann equation and reparametrization of the OBC generalized Born model for nucleic acids and nucleic acid-protein complexes.

    Science.gov (United States)

    Fogolari, Federico; Corazza, Alessandra; Esposito, Gennaro

    2015-04-05

    The generalized Born model in the Onufriev, Bashford, and Case (Onufriev et al., Proteins: Struct Funct Genet 2004, 55, 383) implementation has emerged as one of the best compromises between accuracy and speed of computation. For simulations of nucleic acids, however, a number of issues should be addressed: (1) the generalized Born model is based on a linear model and the linearization of the reference Poisson-Boltmann equation may be questioned for highly charged systems as nucleic acids; (2) although much attention has been given to potentials, solvation forces could be much less sensitive to linearization than the potentials; and (3) the accuracy of the Onufriev-Bashford-Case (OBC) model for nucleic acids depends on fine tuning of parameters. Here, we show that the linearization of the Poisson Boltzmann equation has mild effects on computed forces, and that with optimal choice of the OBC model parameters, solvation forces, essential for molecular dynamics simulations, agree well with those computed using the reference Poisson-Boltzmann model. © 2015 Wiley Periodicals, Inc.

  7. Obtaining the maximum likelihood estimates in incomplete R x C contingency tables using a Poisson generalized linear model

    OpenAIRE

    Lipsitz, Stuart R.; Parzen, Michael; Molenberghs, Geert

    1998-01-01

    This article describes estimation of the cell probabilities in an R x C contingency table with ignorable missing data. Popular methods for maximizing the incomplete data likelihood are the EM-algorithm and the Newton--Raphson algorithm. Both of these methods require some modification of existing statistical software to get the MLEs of the cell probabilities as well as the variance estimates. We make the connection between the multinomial and Poisson likelihoods to show that the MLEs can be ob...

  8. Linear odd Poisson bracket on Grassmann variables

    International Nuclear Information System (INIS)

    Soroka, V.A.

    1999-01-01

    A linear odd Poisson bracket (antibracket) realized solely in terms of Grassmann variables is suggested. It is revealed that the bracket, which corresponds to a semi-simple Lie group, has at once three Grassmann-odd nilpotent Δ-like differential operators of the first, the second and the third orders with respect to Grassmann derivatives, in contrast with the canonical odd Poisson bracket having the only Grassmann-odd nilpotent differential Δ-operator of the second order. It is shown that these Δ-like operators together with a Grassmann-odd nilpotent Casimir function of this bracket form a finite-dimensional Lie superalgebra. (Copyright (c) 1999 Elsevier Science B.V., Amsterdam. All rights reserved.)

  9. A generalized Poisson and Poisson-Boltzmann solver for electrostatic environments

    Energy Technology Data Exchange (ETDEWEB)

    Fisicaro, G., E-mail: giuseppe.fisicaro@unibas.ch; Goedecker, S. [Department of Physics, University of Basel, Klingelbergstrasse 82, 4056 Basel (Switzerland); Genovese, L. [University of Grenoble Alpes, CEA, INAC-SP2M, L-Sim, F-38000 Grenoble (France); Andreussi, O. [Institute of Computational Science, Università della Svizzera Italiana, Via Giuseppe Buffi 13, CH-6904 Lugano (Switzerland); Theory and Simulations of Materials (THEOS) and National Centre for Computational Design and Discovery of Novel Materials (MARVEL), École Polytechnique Fédérale de Lausanne, Station 12, CH-1015 Lausanne (Switzerland); Marzari, N. [Theory and Simulations of Materials (THEOS) and National Centre for Computational Design and Discovery of Novel Materials (MARVEL), École Polytechnique Fédérale de Lausanne, Station 12, CH-1015 Lausanne (Switzerland)

    2016-01-07

    The computational study of chemical reactions in complex, wet environments is critical for applications in many fields. It is often essential to study chemical reactions in the presence of applied electrochemical potentials, taking into account the non-trivial electrostatic screening coming from the solvent and the electrolytes. As a consequence, the electrostatic potential has to be found by solving the generalized Poisson and the Poisson-Boltzmann equations for neutral and ionic solutions, respectively. In the present work, solvers for both problems have been developed. A preconditioned conjugate gradient method has been implemented for the solution of the generalized Poisson equation and the linear regime of the Poisson-Boltzmann, allowing to solve iteratively the minimization problem with some ten iterations of the ordinary Poisson equation solver. In addition, a self-consistent procedure enables us to solve the non-linear Poisson-Boltzmann problem. Both solvers exhibit very high accuracy and parallel efficiency and allow for the treatment of periodic, free, and slab boundary conditions. The solver has been integrated into the BigDFT and Quantum-ESPRESSO electronic-structure packages and will be released as an independent program, suitable for integration in other codes.

  10. A generalized Poisson and Poisson-Boltzmann solver for electrostatic environments

    International Nuclear Information System (INIS)

    Fisicaro, G.; Goedecker, S.; Genovese, L.; Andreussi, O.; Marzari, N.

    2016-01-01

    The computational study of chemical reactions in complex, wet environments is critical for applications in many fields. It is often essential to study chemical reactions in the presence of applied electrochemical potentials, taking into account the non-trivial electrostatic screening coming from the solvent and the electrolytes. As a consequence, the electrostatic potential has to be found by solving the generalized Poisson and the Poisson-Boltzmann equations for neutral and ionic solutions, respectively. In the present work, solvers for both problems have been developed. A preconditioned conjugate gradient method has been implemented for the solution of the generalized Poisson equation and the linear regime of the Poisson-Boltzmann, allowing to solve iteratively the minimization problem with some ten iterations of the ordinary Poisson equation solver. In addition, a self-consistent procedure enables us to solve the non-linear Poisson-Boltzmann problem. Both solvers exhibit very high accuracy and parallel efficiency and allow for the treatment of periodic, free, and slab boundary conditions. The solver has been integrated into the BigDFT and Quantum-ESPRESSO electronic-structure packages and will be released as an independent program, suitable for integration in other codes

  11. Dimensional reduction for generalized Poisson brackets

    Science.gov (United States)

    Acatrinei, Ciprian Sorin

    2008-02-01

    We discuss dimensional reduction for Hamiltonian systems which possess nonconstant Poisson brackets between pairs of coordinates and between pairs of momenta. The associated Jacobi identities imply that the dimensionally reduced brackets are always constant. Some examples are given alongside the general theory.

  12. The Lie-Poisson structure of integrable classical non-linear sigma models

    International Nuclear Information System (INIS)

    Bordemann, M.; Forger, M.; Schaeper, U.; Laartz, J.

    1993-01-01

    The canonical structure of classical non-linear sigma models on Riemannian symmetric spaces, which constitute the most general class of classical non-linear sigma models known to be integrable, is shown to be governed by a fundamental Poisson bracket relation that fits into the r-s-matrix formalism for non-ultralocal integrable models first discussed by Maillet. The matrices r and s are computed explicitly and, being field dependent, satisfy fundamental Poisson bracket relations of their own, which can be expressed in terms of a new numerical matrix c. It is proposed that all these Poisson brackets taken together are representation conditions for a new kind of algebra which, for this class of models, replaces the classical Yang-Baxter algebra governing the canonical structure of ultralocal models. The Poisson brackets for the transition matrices are also computed, and the notorious regularization problem associated with the definition of the Poisson brackets for the monodromy matrices is discussed. (orig.)

  13. Stability of the trivial solution for linear stochastic differential equations with Poisson white noise

    International Nuclear Information System (INIS)

    Grigoriu, Mircea; Samorodnitsky, Gennady

    2004-01-01

    Two methods are considered for assessing the asymptotic stability of the trivial solution of linear stochastic differential equations driven by Poisson white noise, interpreted as the formal derivative of a compound Poisson process. The first method attempts to extend a result for diffusion processes satisfying linear stochastic differential equations to the case of linear equations with Poisson white noise. The developments for the method are based on Ito's formula for semimartingales and Lyapunov exponents. The second method is based on a geometric ergodic theorem for Markov chains providing a criterion for the asymptotic stability of the solution of linear stochastic differential equations with Poisson white noise. Two examples are presented to illustrate the use and evaluate the potential of the two methods. The examples demonstrate limitations of the first method and the generality of the second method

  14. Introduction to generalized linear models

    CERN Document Server

    Dobson, Annette J

    2008-01-01

    Introduction Background Scope Notation Distributions Related to the Normal Distribution Quadratic Forms Estimation Model Fitting Introduction Examples Some Principles of Statistical Modeling Notation and Coding for Explanatory Variables Exponential Family and Generalized Linear Models Introduction Exponential Family of Distributions Properties of Distributions in the Exponential Family Generalized Linear Models Examples Estimation Introduction Example: Failure Times for Pressure Vessels Maximum Likelihood Estimation Poisson Regression Example Inference Introduction Sampling Distribution for Score Statistics Taylor Series Approximations Sampling Distribution for MLEs Log-Likelihood Ratio Statistic Sampling Distribution for the Deviance Hypothesis Testing Normal Linear Models Introduction Basic Results Multiple Linear Regression Analysis of Variance Analysis of Covariance General Linear Models Binary Variables and Logistic Regression Probability Distributions ...

  15. Appearance of eigen modes for the linearized Vlasov-Poisson equation

    International Nuclear Information System (INIS)

    Degond, P.

    1983-01-01

    In order to determine the asymptotic behaviour, when the time goes to infinity, of the solution of the linearized Vlasov-Poisson equation, we use eigen modes, associated to continuous linear functionals on a Banach space of analytic functions [fr

  16. An implicit meshless scheme for the solution of transient non-linear Poisson-type equations

    KAUST Repository

    Bourantas, Georgios

    2013-07-01

    A meshfree point collocation method is used for the numerical simulation of both transient and steady state non-linear Poisson-type partial differential equations. Particular emphasis is placed on the application of the linearization method with special attention to the lagging of coefficients method and the Newton linearization method. The localized form of the Moving Least Squares (MLS) approximation is employed for the construction of the shape functions, in conjunction with the general framework of the point collocation method. Computations are performed for regular nodal distributions, stressing the positivity conditions that make the resulting system stable and convergent. The accuracy and the stability of the proposed scheme are demonstrated through representative and well-established benchmark problems. © 2013 Elsevier Ltd.

  17. A generalized Poisson solver for first-principles device simulations

    Energy Technology Data Exchange (ETDEWEB)

    Bani-Hashemian, Mohammad Hossein; VandeVondele, Joost, E-mail: joost.vandevondele@mat.ethz.ch [Nanoscale Simulations, ETH Zürich, 8093 Zürich (Switzerland); Brück, Sascha; Luisier, Mathieu [Integrated Systems Laboratory, ETH Zürich, 8092 Zürich (Switzerland)

    2016-01-28

    Electronic structure calculations of atomistic systems based on density functional theory involve solving the Poisson equation. In this paper, we present a plane-wave based algorithm for solving the generalized Poisson equation subject to periodic or homogeneous Neumann conditions on the boundaries of the simulation cell and Dirichlet type conditions imposed at arbitrary subdomains. In this way, source, drain, and gate voltages can be imposed across atomistic models of electronic devices. Dirichlet conditions are enforced as constraints in a variational framework giving rise to a saddle point problem. The resulting system of equations is then solved using a stationary iterative method in which the generalized Poisson operator is preconditioned with the standard Laplace operator. The solver can make use of any sufficiently smooth function modelling the dielectric constant, including density dependent dielectric continuum models. For all the boundary conditions, consistent derivatives are available and molecular dynamics simulations can be performed. The convergence behaviour of the scheme is investigated and its capabilities are demonstrated.

  18. An improved FMM Algorithm of the 3d-linearized Poisson-Boltzmann Equation

    Directory of Open Access Journals (Sweden)

    Mehrez issa

    2015-06-01

    Full Text Available This paper presents a new FMM algorithm for the linearized Poisson-Boltzmann equation in three dimensions. The performance of the proposed algorithm is assessed on a example in three dimensions and compared with the direct method. The numerical results show the power of the new method, that allow to achieve the best schemes to reduce the time of the particle interactions, which are based on diagonal form of translation operators for linearized Poisson-Boltzmann equation.

  19. A Note on the Identifiability of Generalized Linear Mixed Models

    DEFF Research Database (Denmark)

    Labouriau, Rodrigo

    2014-01-01

    I present here a simple proof that, under general regularity conditions, the standard parametrization of generalized linear mixed model is identifiable. The proof is based on the assumptions of generalized linear mixed models on the first and second order moments and some general mild regularity ...... conditions, and, therefore, is extensible to quasi-likelihood based generalized linear models. In particular, binomial and Poisson mixed models with dispersion parameter are identifiable when equipped with the standard parametrization...

  20. Poisson Autoregression

    DEFF Research Database (Denmark)

    Fokianos, Konstantinos; Rahbek, Anders Christian; Tjøstheim, Dag

    2009-01-01

    In this article we consider geometric ergodicity and likelihood-based inference for linear and nonlinear Poisson autoregression. In the linear case, the conditional mean is linked linearly to its past values, as well as to the observed values of the Poisson process. This also applies to the condi......In this article we consider geometric ergodicity and likelihood-based inference for linear and nonlinear Poisson autoregression. In the linear case, the conditional mean is linked linearly to its past values, as well as to the observed values of the Poisson process. This also applies...... to the conditional variance, making possible interpretation as an integer-valued generalized autoregressive conditional heteroscedasticity process. In a nonlinear conditional Poisson model, the conditional mean is a nonlinear function of its past values and past observations. As a particular example, we consider...... ergodicity proceeds via Markov theory and irreducibility. Finding transparent conditions for proving ergodicity turns out to be a delicate problem in the original model formulation. This problem is circumvented by allowing a perturbation of the model. We show that as the perturbations can be chosen...

  1. A note on the time decay of solutions for the linearized Wigner-Poisson system

    KAUST Repository

    Gamba, Irene

    2009-01-01

    We consider the one-dimensional Wigner-Poisson system of plasma physics, linearized around a (spatially homogeneous) Lorentzian distribution and prove that the solution of the corresponding linearized problem decays to zero in time. We also give an explicit algebraic decay rate.

  2. Noiseless Vlasov–Poisson simulations with linearly transformed particles

    Energy Technology Data Exchange (ETDEWEB)

    Campos Pinto, Martin, E-mail: campos@ann.jussieu.fr [Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); CNRS, UMR 7598, Laboratoire Jacques-Louis Lions, F-75005, Paris (France); UPMC Univ. Paris 06, UMR 7598, Laboratoire Jacques-Louis Lions, F-75005, Paris (France); Sonnendrücker, Eric, E-mail: sonnen@math.unistra.fr [IRMA, UMR 7501, Université de Strasbourg and CNRS, 7 rue René Descartes, F-67084 Strasbourg Cedex (France); Project-team CALVI, INRIA Nancy Grand Est, 7 rue René Descartes, F-67084 Strasbourg Cedex (France); Friedman, Alex, E-mail: af@llnl.gov [Lawrence Livermore National Laboratory, Livermore, CA 94550 (United States); Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Grote, David P., E-mail: grote1@llnl.gov [Lawrence Livermore National Laboratory, Livermore, CA 94550 (United States); Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States); Lund, Steve M., E-mail: smlund@llnl.gov [Lawrence Livermore National Laboratory, Livermore, CA 94550 (United States); Lawrence Berkeley National Laboratory, Berkeley, CA 94720 (United States)

    2014-10-15

    We introduce a deterministic discrete-particle simulation approach, the Linearly-Transformed Particle-In-Cell (LTPIC) method, that employs linear deformations of the particles to reduce the noise traditionally associated with particle schemes. Formally, transforming the particles is justified by local first order expansions of the characteristic flow in phase space. In practice the method amounts of using deformation matrices within the particle shape functions; these matrices are updated via local evaluations of the forward numerical flow. Because it is necessary to periodically remap the particles on a regular grid to avoid excessively deforming their shapes, the method can be seen as a development of Denavit's Forward Semi-Lagrangian (FSL) scheme (Denavit, 1972 [8]). However, it has recently been established (Campos Pinto, 2012 [20]) that the underlying Linearly-Transformed Particle scheme converges for abstract transport problems, with no need to remap the particles; deforming the particles can thus be seen as a way to significantly lower the remapping frequency needed in the FSL schemes, and hence the associated numerical diffusion. To couple the method with electrostatic field solvers, two specific charge deposition schemes are examined, and their performance compared with that of the standard deposition method. Finally, numerical 1d1v simulations involving benchmark test cases and halo formation in an initially mismatched thermal sheet beam demonstrate some advantages of our LTPIC scheme over the classical PIC and FSL methods. Benchmarked test cases also indicate that, for numerical choices involving similar computational effort, the LTPIC method is capable of accuracy comparable to or exceeding that of state-of-the-art, high-resolution Vlasov schemes.

  3. Mean-square state and parameter estimation for stochastic linear systems with Gaussian and Poisson noises

    Science.gov (United States)

    Basin, M.; Maldonado, J. J.; Zendejo, O.

    2016-07-01

    This paper proposes new mean-square filter and parameter estimator design for linear stochastic systems with unknown parameters over linear observations, where unknown parameters are considered as combinations of Gaussian and Poisson white noises. The problem is treated by reducing the original problem to a filtering problem for an extended state vector that includes parameters as additional states, modelled as combinations of independent Gaussian and Poisson processes. The solution to this filtering problem is based on the mean-square filtering equations for incompletely polynomial states confused with Gaussian and Poisson noises over linear observations. The resulting mean-square filter serves as an identifier for the unknown parameters. Finally, a simulation example shows effectiveness of the proposed mean-square filter and parameter estimator.

  4. Particular solutions of generalized Euler-Poisson-Darboux equation

    Directory of Open Access Journals (Sweden)

    Rakhila B. Seilkhanova

    2015-01-01

    Full Text Available In this article we consider the generalized Euler-Poisson-Darboux equation $$ {u}_{tt}+\\frac{2\\gamma }{t}{{u}_{t}}={u}_{xx}+{u}_{yy} +\\frac{2\\alpha }{x}{{u}_{x}}+\\frac{2\\beta }{y}{{u}_y},\\quad x>0,\\;y>0,\\;t>0. $$ We construct particular solutions in an explicit form expressed by the Lauricella hypergeometric function of three variables. Properties of each constructed solutions have been investigated in sections of surfaces of the characteristic cone. Precisely, we prove that found solutions have singularity $1/r$ at $r\\to 0$, where ${{r}^2}={{( x-{{x}_0}}^2}+{{( y-{{y}_0}}^2}-{{( t-{{t}_0}}^2}$.

  5. Linear stability of stationary solutions of the Vlasov-Poisson system in three dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Batt, J.; Rein, G. [Muenchen Univ. (Germany). Mathematisches Inst.; Morrison, P.J. [Texas Univ., Austin, TX (United States)

    1993-03-01

    Rigorous results on the stability of stationary solutions of the Vlasov-Poisson system are obtained in both the plasma physics and stellar dynamics contexts. It is proven that stationary solutions in the plasma physics (stellar dynamics) case are linearly stable if they are decreasing (increasing) functions of the local, i.e. particle, energy. The main tool in the analysis is the free energy of the system, a conserved quantity. In addition, an appropriate global existence result is proven for the linearized Vlasov-Poisson system and the existence of stationary solutions that satisfy the above stability condition is established.

  6. Generalized Linear Covariance Analysis

    Science.gov (United States)

    Carpenter, James R.; Markley, F. Landis

    2014-01-01

    This talk presents a comprehensive approach to filter modeling for generalized covariance analysis of both batch least-squares and sequential estimators. We review and extend in two directions the results of prior work that allowed for partitioning of the state space into solve-for'' and consider'' parameters, accounted for differences between the formal values and the true values of the measurement noise, process noise, and textita priori solve-for and consider covariances, and explicitly partitioned the errors into subspaces containing only the influence of the measurement noise, process noise, and solve-for and consider covariances. In this work, we explicitly add sensitivity analysis to this prior work, and relax an implicit assumption that the batch estimator's epoch time occurs prior to the definitive span. We also apply the method to an integrated orbit and attitude problem, in which gyro and accelerometer errors, though not estimated, influence the orbit determination performance. We illustrate our results using two graphical presentations, which we call the variance sandpile'' and the sensitivity mosaic,'' and we compare the linear covariance results to confidence intervals associated with ensemble statistics from a Monte Carlo analysis.

  7. Foundations of linear and generalized linear models

    CERN Document Server

    Agresti, Alan

    2015-01-01

    A valuable overview of the most important ideas and results in statistical analysis Written by a highly-experienced author, Foundations of Linear and Generalized Linear Models is a clear and comprehensive guide to the key concepts and results of linear statistical models. The book presents a broad, in-depth overview of the most commonly used statistical models by discussing the theory underlying the models, R software applications, and examples with crafted models to elucidate key ideas and promote practical model building. The book begins by illustrating the fundamentals of linear models,

  8. PB-AM: An open-source, fully analytical linear poisson-boltzmann solver

    Energy Technology Data Exchange (ETDEWEB)

    Felberg, Lisa E. [Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley California 94720; Brookes, David H. [Department of Chemistry, University of California Berkeley, Berkeley California 94720; Yap, Eng-Hui [Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx New York 10461; Jurrus, Elizabeth [Division of Computational and Statistical Analytics, Pacific Northwest National Laboratory, Richland Washington 99352; Scientific Computing and Imaging Institute, University of Utah, Salt Lake City Utah 84112; Baker, Nathan A. [Advanced Computing, Mathematics, and Data Division, Pacific Northwest National Laboratory, Richland Washington 99352; Division of Applied Mathematics, Brown University, Providence Rhode Island 02912; Head-Gordon, Teresa [Department of Chemical and Biomolecular Engineering, University of California Berkeley, Berkeley California 94720; Department of Chemistry, University of California Berkeley, Berkeley California 94720; Department of Bioengineering, University of California Berkeley, Berkeley California 94720; Chemical Sciences Division, Lawrence Berkeley National Labs, Berkeley California 94720

    2016-11-02

    We present the open source distributed software package Poisson-Boltzmann Analytical Method (PB-AM), a fully analytical solution to the linearized Poisson Boltzmann equation. The PB-AM software package includes the generation of outputs files appropriate for visualization using VMD, a Brownian dynamics scheme that uses periodic boundary conditions to simulate dynamics, the ability to specify docking criteria, and offers two different kinetics schemes to evaluate biomolecular association rate constants. Given that PB-AM defines mutual polarization completely and accurately, it can be refactored as a many-body expansion to explore 2- and 3-body polarization. Additionally, the software has been integrated into the Adaptive Poisson-Boltzmann Solver (APBS) software package to make it more accessible to a larger group of scientists, educators and students that are more familiar with the APBS framework.

  9. Fiber-wise linear Poisson structures related to W∗-algebras

    Science.gov (United States)

    Odzijewicz, Anatol; Jakimowicz, Grzegorz; Sliżewska, Aneta

    2018-01-01

    In the framework of Banach differential geometry we investigate the fiber-wise linear Poisson structures as well as the Lie groupoid and Lie algebroid structures which are defined in the canonical way by the structure of a W∗-algebra (von Neumann algebra) M. The main role in this theory is played by the complex Banach-Lie groupoid G(M) ⇉ L(M) of partially invertible elements of M over the lattice L(M) of orthogonal projections of M. The Atiyah sequence and the predual Atiyah sequence corresponding to this groupoid are investigated from the point of view of Banach Poisson geometry. In particular we show that the predual Atiyah sequence fits in a short exact sequence of complex Banach sub-Poisson V B-groupoids with G(M) ⇉ L(M) as the side groupoid.

  10. Poisson-generalized gamma empirical Bayes model for disease ...

    African Journals Online (AJOL)

    In spatial disease mapping, the use of Bayesian models of estimation technique is becoming popular for smoothing relative risks estimates for disease mapping. The most common Bayesian conjugate model for disease mapping is the Poisson-Gamma Model (PG). To explore further the activity of smoothing of relative risk ...

  11. FOOD INSECURITY AND EDUCATIONAL ACHIEVEMENT: A MULTI-LEVEL GENERALIZATION OF POISSON REGRESSION

    Directory of Open Access Journals (Sweden)

    Allison Jennifer Ames

    2016-01-01

    Full Text Available This research examined the relationship between food insecurity, the National School Lunch Program (NSLP, and academic achievement in Georgia’s public school system. Georgia is located in the southern U.S. states, where food insecurity has been particularly prevalent. A multilevel Poisson generalized linear model was used to examine the relationship between food insecurity and academic achievement. Findings confirm a strong inverse relationship between food insecurity, as exhibited by participation in the National School Lunch Program, and academic achievement for elementary-age children. The strength of the relationship between food insecurity and academic achievement was different for the younger, elementary-age students (fifth grade than for the older, middle school-age (eighth grade students, a key distinction between this study and other research.

  12. Aspects of general linear modelling of migration.

    Science.gov (United States)

    Congdon, P

    1992-01-01

    "This paper investigates the application of general linear modelling principles to analysing migration flows between areas. Particular attention is paid to specifying the form of the regression and error components, and the nature of departures from Poisson randomness. Extensions to take account of spatial and temporal correlation are discussed as well as constrained estimation. The issue of specification bears on the testing of migration theories, and assessing the role migration plays in job and housing markets: the direction and significance of the effects of economic variates on migration depends on the specification of the statistical model. The application is in the context of migration in London and South East England in the 1970s and 1980s." excerpt

  13. Linear response in aging glassy systems, intermittency and the Poisson statistics of record fluctuations

    DEFF Research Database (Denmark)

    Sibani, Paolo

    2007-01-01

    in a correlated fashion and through irreversible bursts, `quakes', which punctuate reversible and equilibrium-like fluctuations of zero average. The temporal distribution of the quakes is a Poisson distribution with an average growing logarithmically on time, indicating that the quakes are triggered by record...... to capture the time dependencies of the EA simulation results. Finally, we argue that whenever the changes of the linear response function and of its conjugate autocorrelation function follow from the same intermittent events a fluctuation-dissipation-like relation can arise between the two in off......We study the intermittent behavior of the energy decay and the linear magnetic response of a glassy system during isothermal aging after a deep thermal quench, using the Edward-Anderson spin glass model as a paradigmatic example. The large intermittent changes in the two observables occur...

  14. Generalized, Linear, and Mixed Models

    CERN Document Server

    McCulloch, Charles E; Neuhaus, John M

    2011-01-01

    An accessible and self-contained introduction to statistical models-now in a modernized new editionGeneralized, Linear, and Mixed Models, Second Edition provides an up-to-date treatment of the essential techniques for developing and applying a wide variety of statistical models. The book presents thorough and unified coverage of the theory behind generalized, linear, and mixed models and highlights their similarities and differences in various construction, application, and computational aspects.A clear introduction to the basic ideas of fixed effects models, random effects models, and mixed m

  15. Multivariate covariance generalized linear models

    DEFF Research Database (Denmark)

    Bonat, W. H.; Jørgensen, Bent

    2016-01-01

    We propose a general framework for non-normal multivariate data analysis called multivariate covariance generalized linear models, designed to handle multivariate response variables, along with a wide range of temporal and spatial correlation structures defined in terms of a covariance link...... function combined with a matrix linear predictor involving known matrices. The method is motivated by three data examples that are not easily handled by existing methods. The first example concerns multivariate count data, the second involves response variables of mixed types, combined with repeated...... measures and longitudinal structures, and the third involves a spatiotemporal analysis of rainfall data. The models take non-normality into account in the conventional way by means of a variance function, and the mean structure is modelled by means of a link function and a linear predictor. The models...

  16. On the Linear Stability of Crystals in the Schrödinger-Poisson Model

    Science.gov (United States)

    Komech, A.; Kopylova, E.

    2016-10-01

    We consider the Schrödinger-Poisson-Newton equations for crystals with one ion per cell. We linearize this dynamics at the periodic minimizers of energy per cell and introduce a novel class of the ion charge densities that ensures the stability of the linearized dynamics. Our main result is the energy positivity for the Bloch generators of the linearized dynamics under a Wiener-type condition on the ion charge density. We also adopt an additional `Jellium' condition which cancels the negative contribution caused by the electrostatic instability and provides the `Jellium' periodic minimizers and the optimality of the lattice: the energy per cell of the periodic minimizer attains the global minimum among all possible lattices. We show that the energy positivity can fail if the Jellium condition is violated, while the Wiener condition holds. The proof of the energy positivity relies on a novel factorization of the corresponding Hamilton functional. The Bloch generators are nonselfadjoint (and even nonsymmetric) Hamilton operators. We diagonalize these generators using our theory of spectral resolution of the Hamilton operators with positive definite energy (Komech and Kopylova in, J Stat Phys 154(1-2):503-521, 2014, J Spectral Theory 5(2):331-361, 2015). The stability of the linearized crystal dynamics is established using this spectral resolution.

  17. Non linear Euler-Poisson system. Part 1: global existence of low entropy solutions

    International Nuclear Information System (INIS)

    Cordier, S.

    1995-05-01

    In this work a 1-D model of electrons and ions plasma is considered. Electrons are supposed to be in Maxwell-Boltzmann thermodynamic equilibrium while ions are described with an isothermal flow model of charged particles submitted to a self-consistent electric field. A collision term between neutral particles and ions simulates the presence of neutral particles. This work demonstrates the existence of low entropy solutions for this simple model with arbitrary initial conditions. Most of the paper is devoted to the demonstration of this theorem and follows the successive steps: construction of a numerical scheme, recall of the classical properties of Riemann problem solutions using Glimm method, uniform estimations for the whole variation norm, and finally, convergence of the constructed solutions towards a low entropy solution for the non-linear Euler/Poisson system. Domains of application for this type of model are listed in the conclusion. (J.S.). 18 refs

  18. The linearized pressure Poisson equation for global instability analysis of incompressible flows

    Science.gov (United States)

    Theofilis, Vassilis

    2017-12-01

    The linearized pressure Poisson equation (LPPE) is used in two and three spatial dimensions in the respective matrix-forming solution of the BiGlobal and TriGlobal eigenvalue problem in primitive variables on collocated grids. It provides a disturbance pressure boundary condition which is compatible with the recovery of perturbation velocity components that satisfy exactly the linearized continuity equation. The LPPE is employed to analyze instability in wall-bounded flows and in the prototype open Blasius boundary layer flow. In the closed flows, excellent agreement is shown between results of the LPPE and those of global linear instability analyses based on the time-stepping nektar++, Semtex and nek5000 codes, as well as with those obtained from the FreeFEM++ matrix-forming code. In the flat plate boundary layer, solutions extracted from the two-dimensional LPPE eigenvector at constant streamwise locations are found to be in very good agreement with profiles delivered by the NOLOT/PSE space marching code. Benchmark eigenvalue data are provided in all flows analyzed. The performance of the LPPE is seen to be superior to that of the commonly used pressure compatibility (PC) boundary condition: at any given resolution, the discrete part of the LPPE eigenspectrum contains converged and not converged, but physically correct, eigenvalues. By contrast, the PC boundary closure delivers some of the LPPE eigenvalues and, in addition, physically wrong eigenmodes. It is concluded that the LPPE should be used in place of the PC pressure boundary closure, when BiGlobal or TriGlobal eigenvalue problems are solved in primitive variables by the matrix-forming approach on collocated grids.

  19. Ionic screening of charged impurities in electrolytically gated graphene: A partially linearized Poisson-Boltzmann model.

    Science.gov (United States)

    Sharma, P; Mišković, Z L

    2015-10-07

    We present a model describing the electrostatic interactions across a structure that consists of a single layer of graphene with large area, lying above an oxide substrate of finite thickness, with its surface exposed to a thick layer of liquid electrolyte containing salt ions. Our goal is to analyze the co-operative screening of the potential fluctuation in a doped graphene due to randomness in the positions of fixed charged impurities in the oxide by the charge carriers in graphene and by the mobile ions in the diffuse layer of the electrolyte. In order to account for a possibly large potential drop in the diffuse later that may arise in an electrolytically gated graphene, we use a partially linearized Poisson-Boltzmann (PB) model of the electrolyte, in which we solve a fully nonlinear PB equation for the surface average of the potential in one dimension, whereas the lateral fluctuations of the potential in graphene are tackled by linearizing the PB equation about the average potential. In this way, we are able to describe the regime of equilibrium doping of graphene to large densities for arbitrary values of the ion concentration without restrictions to the potential drop in the electrolyte. We evaluate the electrostatic Green's function for the partially linearized PB model, which is used to express the screening contributions of the graphene layer and the nearby electrolyte by means of an effective dielectric function. We find that, while the screened potential of a single charged impurity at large in-graphene distances exhibits a strong dependence on the ion concentration in the electrolyte and on the doping density in graphene, in the case of a spatially correlated two-dimensional ensemble of impurities, this dependence is largely suppressed in the autocovariance of the fluctuating potential.

  20. Assessment of Poisson, logit, and linear models for genetic analysis of clinical mastitis in Norwegian Red cows.

    Science.gov (United States)

    Vazquez, A I; Gianola, D; Bates, D; Weigel, K A; Heringstad, B

    2009-02-01

    Clinical mastitis is typically coded as presence/absence during some period of exposure, and records are analyzed with linear or binary data models. Because presence includes cows with multiple episodes, there is loss of information when a count is treated as a binary response. The Poisson model is designed for counting random variables, and although it is used extensively in epidemiology of mastitis, it has rarely been used for studying the genetics of mastitis. Many models have been proposed for genetic analysis of mastitis, but they have not been formally compared. The main goal of this study was to compare linear (Gaussian), Bernoulli (with logit link), and Poisson models for the purpose of genetic evaluation of sires for mastitis in dairy cattle. The response variables were clinical mastitis (CM; 0, 1) and number of CM cases (NCM; 0, 1, 2, ..). Data consisted of records on 36,178 first-lactation daughters of 245 Norwegian Red sires distributed over 5,286 herds. Predictive ability of models was assessed via a 3-fold cross-validation using mean squared error of prediction (MSEP) as the end-point. Between-sire variance estimates for NCM were 0.065 in Poisson and 0.007 in the linear model. For CM the between-sire variance was 0.093 in logit and 0.003 in the linear model. The ratio between herd and sire variances for the models with NCM response was 4.6 and 3.5 for Poisson and linear, respectively, and for model for CM was 3.7 in both logit and linear models. The MSEP for all cows was similar. However, within healthy animals, MSEP was 0.085 (Poisson), 0.090 (linear for NCM), 0.053 (logit), and 0.056 (linear for CM). For mastitic animals the MSEP values were 1.206 (Poisson), 1.185 (linear for NCM response), 1.333 (logit), and 1.319 (linear for CM response). The models for count variables had a better performance when predicting diseased animals and also had a similar performance between them. Logit and linear models for CM had better predictive ability for healthy

  1. Poisson Autoregression

    DEFF Research Database (Denmark)

    Fokianos, Konstantinos; Rahbek, Anders Christian; Tjøstheim, Dag

    This paper considers geometric ergodicity and likelihood based inference for linear and nonlinear Poisson autoregressions. In the linear case the conditional mean is linked linearly to its past values as well as the observed values of the Poisson process. This also applies to the conditional...... variance, implying an interpretation as an integer valued GARCH process. In a nonlinear conditional Poisson model, the conditional mean is a nonlinear function of its past values and a nonlinear function of past observations. As a particular example an exponential autoregressive Poisson model for time...... series is considered. Under geometric ergodicity the maximum likelihood estimators of the parameters are shown to be asymptotically Gaussian in the linear model. In addition we provide a consistent estimator of the asymptotic covariance, which is used in the simulations and the analysis of some...

  2. General solution of Poisson equation in three dimensions for disk-like galaxies

    International Nuclear Information System (INIS)

    Tong, Y.; Zheng, X.; Peng, O.

    1982-01-01

    The general solution of the Poisson equation is solved by means of integral transformations for Vertical BarkVertical Barr>>1 provided that the perturbed density of disk-like galaxies distributes along the radial direction according to the Hankel function. This solution can more accurately represent the outer spiral arms of disk-like galaxies

  3. Dynamic Response of Non-Linear Inelsatic Systems to Poisson-Driven Stochastic Excitations

    DEFF Research Database (Denmark)

    Nielsen, Søren R. K.; Iwankiewicz, R.

    A single-degree-of-freedom inelastic system subject to a stochastic excitation in form of a Poisson-distributed train of impulses is considered. The state variables of the system form a non-diffusive, Poisson-driven Markov process. Two approximate analytical techniques are developed: modification...

  4. A Kronecker product variant of the FACR method for solving the generalized Poisson equation

    Science.gov (United States)

    Hendrickx, Jef; van Barel, Marc

    2002-03-01

    We present a fast direct method for the solution of a linear system , where M is a block tridiagonal Toeplitzmatrix with A on the diagonal and T on the two subdiagonals (A and T commute). Such matrices are obtained from a finite difference approximation to Poisson's equation with nonconstant coefficients in one direction (among others). The new method is called KPCR(l)-method and begins with l steps of cyclic reduction after which the remaining system is solved by a Kronecker product method. For an appropriate choice of l the asymptotic operation count for an n×n grid is O(n2 log2 log2 n), which is faster than either cyclic reduction or the Kronecker product method itself. The algorithm is similar to and has the same complexity as the FACR(l)-algorithm, which is a combination of cyclic reduction and Fourier analysis (or matrix decomposition). However, the FACR(l)-algorithm only reaches this complexity if A (and T) can be diagonalized by a fast transformation, where the new method is fast for every banded A and T. Moreover, the KPCR(l)-method can be easily generalized to the case where A and T do not commute.

  5. Response analysis of a class of quasi-linear systems with fractional derivative excited by Poisson white noise

    Science.gov (United States)

    Yang, Yongge; Xu, Wei; Yang, Guidong; Jia, Wantao

    2016-08-01

    The Poisson white noise, as a typical non-Gaussian excitation, has attracted much attention recently. However, little work was referred to the study of stochastic systems with fractional derivative under Poisson white noise excitation. This paper investigates the stationary response of a class of quasi-linear systems with fractional derivative excited by Poisson white noise. The equivalent stochastic system of the original stochastic system is obtained. Then, approximate stationary solutions are obtained with the help of the perturbation method. Finally, two typical examples are discussed in detail to demonstrate the effectiveness of the proposed method. The analysis also shows that the fractional order and the fractional coefficient significantly affect the responses of the stochastic systems with fractional derivative.

  6. A Generalized FDM for solving the Poisson's Equation on 3D Irregular Domains

    Directory of Open Access Journals (Sweden)

    J. Izadian

    2014-01-01

    Full Text Available In this paper a new method for solving the Poisson's equation with Dirichlet conditions on irregular domains is presented. For this purpose a generalized finite differences method is applied for numerical differentiation on irregular meshes. Three examples on cylindrical and spherical domains are considered. The numerical results are compared with analytical solution. These results show the performance and efficiency of the proposed method.

  7. Poisson Autoregression

    DEFF Research Database (Denmark)

    Fokianos, Konstantinos; Rahbæk, Anders; Tjøstheim, Dag

    This paper considers geometric ergodicity and likelihood based inference for linear and nonlinear Poisson autoregressions. In the linear case the conditional mean is linked linearly to its past values as well as the observed values of the Poisson process. This also applies to the conditional...... proceeds via Markov theory and irreducibility. Finding transparent conditions for proving ergodicity turns out to be a delicate problem in the original model formulation. This problem is circumvented by allowing a perturbation of the model. We show that as the perturbations can be chosen to be arbitrarily...

  8. Comparison of Efficiency in Generalized Poisson Regression Model and the Standard Poisson Regression Model in analyzing Fertility Behavior among Women, Kashan, 2012

    Directory of Open Access Journals (Sweden)

    Hossein Fallahzadeh

    2017-05-01

    Full Text Available Introduction: Different statistical methods can be used to analyze fertility data. When the response variable is discrete, Poisson model is applied. If the condition does not hold for the Poisson model, its generalized model will be applied. The goal of this study was to compare the efficiency of generalized Poisson regression model with the standard Poisson regression model in estimating the coefficient of effective factors onthe current number of children. Methods: This is a cross-sectional study carried out on a populationof married women within the age range of15-49 years in Kashan, Iran. The cluster sampling method was used for data collection. Clusters consisted ofthe urbanblocksdeterminedby the municipality.Atotal number of10clusters each containing30households was selected according to the health center's framework. The necessary data were then collected through a self-madequestionnaireanddirectinterviewswith women under study. Further, the data analysiswas performed by usingthe standard and generalizedPoisson regression models through theRsoftware. Results: The average number of children for each woman was 1.45 with a variance of 1.073.A significant relationship was observed between the husband's age, number of unwanted pregnancies, and the average durationof breastfeeding with the present number of children in the two standard and generalized Poisson regression models (p < 0.05.The mean ageof women  participating in thisstudy was33.1± 7.57 years (from 25.53 years to 40.67, themean age of marriage was 20.09 ± 3.82 (from16.27 years to23.91, and themean age of their husbands was 37.9 ± 8.4years (from 29.5 years to 46.3. In the current study, the majority of women werein the age range of 30-35years old with the medianof 32years, however, most ofmen were in the age range of 35-40yearswith the median of37years. While 236of women did not have unwanted pregnancies, most participants of the present study had one unwanted pregnancy

  9. Linear Versus Non-linear Supersymmetry, in General

    CERN Document Server

    Ferrara, Sergio; Van Proeyen, Antoine; Wrase, Timm

    2016-01-01

    We study superconformal and supergravity models with constrained superfields. The underlying version of such models with all unconstrained superfields and linearly realized supersymmetry is presented here, in addition to the physical multiplets there are Lagrange multiplier (LM) superfields. Once the equations of motion for the LM superfields are solved, some of the physical superfields become constrained. The linear supersymmetry of the original models becomes non-linearly realized, its exact form can be deduced from the original linear supersymmetry. Known examples of constrained superfields are shown to require the following LM's: chiral superfields, linear superfields, general complex superfields, some of them are multiplets with a spin.

  10. Development of a Generalized Version of the Poisson-Nernst-Planck Equations Using the Hybrid Mixture Theory: Presentation of 2D Numerical Examples

    DEFF Research Database (Denmark)

    Johannesson, Björn

    2010-01-01

    A numerical scheme for the transient solution of generalized version of the Poisson-Nernst-Planck equations is presented. The finite element method is used to establish the coupled non-linear matrix system of equations capable of solving the present problem iteratively. The Poisson-Nernst-Planck ......A numerical scheme for the transient solution of generalized version of the Poisson-Nernst-Planck equations is presented. The finite element method is used to establish the coupled non-linear matrix system of equations capable of solving the present problem iteratively. The Poisson......-Nernst-Planck equations represent a set of diffusion equations for charged species, i.e. dissolved ions. These equations are coupled to the ‘internally’ induced electrical field and to the velocity field of the fluid. The Nernst-Planck equations describing the diffusion of the ionic species and the Gauss’ law in used are......, however, coupled in both directions. The governed set of equations is derived from a simplified version of the so-called hybrid mixture theory (HMT). This theory is a special version of the more ‘classical’ continuum mixture theories in the sense that it works with averaged equations at macro...

  11. Actuarial statistics with generalized linear mixed models

    NARCIS (Netherlands)

    Antonio, K.; Beirlant, J.

    2007-01-01

    Over the last decade the use of generalized linear models (GLMs) in actuarial statistics has received a lot of attention, starting from the actuarial illustrations in the standard text by McCullagh and Nelder [McCullagh, P., Nelder, J.A., 1989. Generalized linear models. In: Monographs on Statistics

  12. General form of the Euler-Poisson-Darboux equation and application of the transmutation method

    Directory of Open Access Journals (Sweden)

    Elina L. Shishkina

    2017-07-01

    Full Text Available In this article, we find solution representations in the compact integral form to the Cauchy problem for a general form of the Euler-Poisson-Darboux equation with Bessel operators via generalized translation and spherical mean operators for all values of the parameter k, including also not studying before exceptional odd negative values. We use a Hankel transform method to prove results in a unified way. Under additional conditions we prove that a distributional solution is a classical one too. A transmutation property for connected generalized spherical mean is proved and importance of applying transmutation methods for differential equations with Bessel operators is emphasized. The paper also contains a short historical introduction on differential equations with Bessel operators and a rather detailed reference list of monographs and papers on mathematical theory and applications of this class of differential equations.

  13. A Combined MPI-CUDA Parallel Solution of Linear and Nonlinear Poisson-Boltzmann Equation

    Directory of Open Access Journals (Sweden)

    José Colmenares

    2014-01-01

    Full Text Available The Poisson-Boltzmann equation models the electrostatic potential generated by fixed charges on a polarizable solute immersed in an ionic solution. This approach is often used in computational structural biology to estimate the electrostatic energetic component of the assembly of molecular biological systems. In the last decades, the amount of data concerning proteins and other biological macromolecules has remarkably increased. To fruitfully exploit these data, a huge computational power is needed as well as software tools capable of exploiting it. It is therefore necessary to move towards high performance computing and to develop proper parallel implementations of already existing and of novel algorithms. Nowadays, workstations can provide an amazing computational power: up to 10 TFLOPS on a single machine equipped with multiple CPUs and accelerators such as Intel Xeon Phi or GPU devices. The actual obstacle to the full exploitation of modern heterogeneous resources is efficient parallel coding and porting of software on such architectures. In this paper, we propose the implementation of a full Poisson-Boltzmann solver based on a finite-difference scheme using different and combined parallel schemes and in particular a mixed MPI-CUDA implementation. Results show great speedups when using the two schemes, achieving an 18.9x speedup using three GPUs.

  14. Linear and Generalized Linear Mixed Models and Their Applications

    CERN Document Server

    Jiang, Jiming

    2007-01-01

    This book covers two major classes of mixed effects models, linear mixed models and generalized linear mixed models, and it presents an up-to-date account of theory and methods in analysis of these models as well as their applications in various fields. The book offers a systematic approach to inference about non-Gaussian linear mixed models. Furthermore, it has included recently developed methods, such as mixed model diagnostics, mixed model selection, and jackknife method in the context of mixed models. The book is aimed at students, researchers and other practitioners who are interested

  15. Multivariate generalized linear mixed models using R

    CERN Document Server

    Berridge, Damon Mark

    2011-01-01

    Multivariate Generalized Linear Mixed Models Using R presents robust and methodologically sound models for analyzing large and complex data sets, enabling readers to answer increasingly complex research questions. The book applies the principles of modeling to longitudinal data from panel and related studies via the Sabre software package in R. A Unified Framework for a Broad Class of Models The authors first discuss members of the family of generalized linear models, gradually adding complexity to the modeling framework by incorporating random effects. After reviewing the generalized linear model notation, they illustrate a range of random effects models, including three-level, multivariate, endpoint, event history, and state dependence models. They estimate the multivariate generalized linear mixed models (MGLMMs) using either standard or adaptive Gaussian quadrature. The authors also compare two-level fixed and random effects linear models. The appendices contain additional information on quadrature, model...

  16. Stochastic foundations of undulatory transport phenomena: generalized Poisson-Kac processes—part I basic theory

    Science.gov (United States)

    Giona, Massimiliano; Brasiello, Antonio; Crescitelli, Silvestro

    2017-08-01

    This article introduces the notion of generalized Poisson-Kac (GPK) processes which generalize the class of ‘telegrapher’s noise dynamics’ introduced by Kac (1974 Rocky Mount. J. Math. 4 497) in 1974, using Poissonian stochastic perturbations. In GPK processes the stochastic perturbation acts as a switching amongst a set of stochastic velocity vectors controlled by a Markov-chain dynamics. GPK processes possess trajectory regularity (almost everywhere) and asymptotic Kac limit, namely the convergence towards Brownian motion (and to stochastic dynamics driven by Wiener perturbations), which characterizes also the long-term/long-distance properties of these processes. In this article we introduce the structural properties of GPK processes, leaving all the physical implications to part II and part III (Giona et al 2016a J. Phys. A: Math. Theor., 2016b J. Phys. A: Math. Theor.).

  17. Generalized Linear Models in Family Studies

    Science.gov (United States)

    Wu, Zheng

    2005-01-01

    Generalized linear models (GLMs), as defined by J. A. Nelder and R. W. M. Wedderburn (1972), unify a class of regression models for categorical, discrete, and continuous response variables. As an extension of classical linear models, GLMs provide a common body of theory and methodology for some seemingly unrelated models and procedures, such as…

  18. On linear equations with general polynomial solutions

    Science.gov (United States)

    Laradji, A.

    2018-04-01

    We provide necessary and sufficient conditions for which an nth-order linear differential equation has a general polynomial solution. We also give necessary conditions that can directly be ascertained from the coefficient functions of the equation.

  19. First-passage time statistics in a bistable system subject to Poisson white noise by the generalized cell mapping method

    Science.gov (United States)

    Han, Qun; Xu, Wei; Yue, Xiaole; Zhang, Ying

    2015-06-01

    The first-passage time statistics in a bistable system subject to Poisson white noise is studied by using the generalized cell mapping method. Specifically, an approximate solution for the first-passage time statistics in a second-order bistable system is developed by analyzing the motions in double-well potential and the global dynamics in phase space. Both symmetric and asymmetric cases have been investigated, and the effects of noise intensity and mean arrival rate of impulse on the first-passage time statistics are discussed respectively. It shows that the effect of Poisson white noise excitation on the first-passage time is quite different from that of the Gaussian one. With the same noise intensity, Poisson white noise can make for a faster first-passage.

  20. Generalized Cross-Gramian for Linear Systems

    DEFF Research Database (Denmark)

    Shaker, Hamid Reza

    2012-01-01

    The cross-gramian is a well-known matrix with embedded controllability and observability information. The cross-gramian is related to the Hankel operator and the Hankel singular values of a linear square system and it has several interesting properties. These properties make the cross-gramian pop......The cross-gramian is a well-known matrix with embedded controllability and observability information. The cross-gramian is related to the Hankel operator and the Hankel singular values of a linear square system and it has several interesting properties. These properties make the cross......-gramian popular in several applications including model reduction, control configuration selection and sensitivity analysis. The ordinary cross-gramian which has been defined in the literature is the solution of a Sylvester equation. This Sylvester equation is not always solvable and therefore for some linear...... square symmetric systems, the ordinary cross-gramian does not exist. To cope with this problem, a new generalized cross-gramian is introduced in this paper. In contrast to the ordinary cross-gramian, the generalized cross-gramian can be easily obtained for general linear systems and therefore can be used...

  1. Generalized linear model for partially ordered data.

    Science.gov (United States)

    Zhang, Qiang; Ip, Edward Haksing

    2012-01-13

    Within the rich literature on generalized linear models, substantial efforts have been devoted to models for categorical responses that are either completely ordered or completely unordered. Few studies have focused on the analysis of partially ordered outcomes, which arise in practically every area of study, including medicine, the social sciences, and education. To fill this gap, we propose a new class of generalized linear models--the partitioned conditional model--that includes models for both ordinal and unordered categorical data as special cases. We discuss the specification of the partitioned conditional model and its estimation. We use an application of the method to a sample of the National Longitudinal Study of Youth to illustrate how the new method is able to extract from partially ordered data useful information about smoking youths that is not possible using traditional methods. Copyright © 2011 John Wiley & Sons, Ltd.

  2. General solution of linear vector supersymmetry

    International Nuclear Information System (INIS)

    Blasi, Alberto; Maggiore, Nicola

    2007-01-01

    We give the general solution of the Ward identity for the linear vector supersymmetry which characterizes all topological models. Such a solution, whose expression is quite compact and simple, greatly simplifies the study of theories displaying a supersymmetric algebraic structure, reducing to a few lines the proof of their possible finiteness. In particular, the cohomology technology, usually involved for the quantum extension of these theories, is completely bypassed. The case of Chern-Simons theory is taken as an example

  3. Identification of general linear mechanical systems

    Science.gov (United States)

    Sirlin, S. W.; Longman, R. W.; Juang, J. N.

    1983-01-01

    Previous work in identification theory has been concerned with the general first order time derivative form. Linear mechanical systems, a large and important class, naturally have a second order form. This paper utilizes this additional structural information for the purpose of identification. A realization is obtained from input-output data, and then knowledge of the system input, output, and inertia matrices is used to determine a set of linear equations whereby we identify the remaining unknown system matrices. Necessary and sufficient conditions on the number, type and placement of sensors and actuators are given which guarantee identificability, and less stringent conditions are given which guarantee generic identifiability. Both a priori identifiability and a posteriori identifiability are considered, i.e., identifiability being insured prior to obtaining data, and identifiability being assured with a given data set.

  4. Gravitational Wave in Linear General Relativity

    Science.gov (United States)

    Cubillos, D. J.

    2017-07-01

    General relativity is the best theory currently available to describe the interaction due to gravity. Within Albert Einstein's field equations this interaction is described by means of the spatiotemporal curvature generated by the matter-energy content in the universe. Weyl worked on the existence of perturbations of the curvature of space-time that propagate at the speed of light, which are known as Gravitational Waves, obtained to a first approximation through the linearization of the field equations of Einstein. Weyl's solution consists of taking the field equations in a vacuum and disturbing the metric, using the Minkowski metric slightly perturbed by a factor ɛ greater than zero but much smaller than one. If the feedback effect of the field is neglected, it can be considered as a weak field solution. After introducing the disturbed metric and ignoring ɛ terms of order greater than one, we can find the linearized field equations in terms of the perturbation, which can then be expressed in terms of the Dalambertian operator of the perturbation equalized to zero. This is analogous to the linear wave equation in classical mechanics, which can be interpreted by saying that gravitational effects propagate as waves at the speed of light. In addition to this, by studying the motion of a particle affected by this perturbation through the geodesic equation can show the transversal character of the gravitational wave and its two possible states of polarization. It can be shown that the energy carried by the wave is of the order of 1/c5 where c is the speed of light, which explains that its effects on matter are very small and very difficult to detect.

  5. Generalized continuous linear model of international trade

    Directory of Open Access Journals (Sweden)

    Kostenko Elena

    2014-01-01

    Full Text Available The probability-based approach to the linear model of international trade based on the theory of Markov processes with continuous time is analysed. A generalized continuous model of international trade is built, in which the transition of the system from state to state is described by linear differential equations. The methodology of how to obtain the intensity matrices, which are differential in nature, is shown, and the same is done for their corresponding transition matrices for processes of purchasing and selling. In the process of the creation of the continuous model, functions and operations of matrices were used in addition to the Laplace transform, which gave the analytical form of the transition matrices, and therefore the expressions for the state vectors of the system. The obtained expressions simplify analysis and calculations in comparison to other methods. The values of the continuous transition matrices include in themselves the results of discrete model of international trade at moments in time proportional to the time step. The continuous model improves the quality of planning and the effectiveness of control of international trade agreements.

  6. FAVORING PARTIES BY GENERAL LINEAR DIVISOR METHOD

    Directory of Open Access Journals (Sweden)

    Ion BOLUN

    2016-03-01

    Full Text Available Aspects of General Linear Divisor (GLDmethod favoring of parties, when distributing seats, are investigated. They are identified predisposing conditions of a particular party to favor parties and also the fact that predisposition of favoring smaller parties is increasing, and of favoring of larger parties is decreasing with the increase of constant c value. The condition of Hamilton equilibrium between two parties is defined and special cases of Hamilton equilibriumand quasi-equilibrium are described. Are identified areas of GLD method favoring of larger and of smaller parties depending on the number of parties and on values of constant c and ΔM. Onaverage, GLD method favors large parties at c 2 and did not favor any party at c = 2.

  7. Derivation of relativistic wave equation from the Poisson process

    Indian Academy of Sciences (India)

    Abstract. A Poisson process is one of the fundamental descriptions for relativistic particles: both fermions and bosons. A generalized linear photon wave equation in dispersive and homogeneous medium with dissipation is derived using the formulation of the Poisson process. This formulation provides a possible ...

  8. Multivariate generalized linear model for genetic pleiotropy.

    Science.gov (United States)

    Schaid, Daniel J; Tong, Xingwei; Batzler, Anthony; Sinnwell, Jason P; Qing, Jiang; Biernacka, Joanna M

    2017-12-16

    When a single gene influences more than one trait, known as pleiotropy, it is important to detect pleiotropy to improve the biological understanding of a gene. This can lead to improved screening, diagnosis, and treatment of diseases. Yet, most current multivariate methods to evaluate pleiotropy test the null hypothesis that none of the traits are associated with a variant; departures from the null could be driven by just one associated trait. A formal test of pleiotropy should assume a null hypothesis that one or fewer traits are associated with a genetic variant. We recently developed statistical methods to analyze pleiotropy for quantitative traits having a multivariate normal distribution. We now extend this approach to traits that can be modeled by generalized linear models, such as analysis of binary, ordinal, or quantitative traits, or a mixture of these types of traits. Based on methods from estimating equations, we developed a new test for pleiotropy. We then extended the testing framework to a sequential approach to test the null hypothesis that $k+1$ traits are associated, given that the null of $k$ associated traits was rejected. This provides a testing framework to determine the number of traits associated with a genetic variant, as well as which traits, while accounting for correlations among the traits. By simulations, we illustrate the Type-I error rate and power of our new methods, describe how they are influenced by sample size, the number of traits, and the trait correlations, and apply the new methods to a genome-wide association study of multivariate traits measuring symptoms of major depression. Our new approach provides a quantitative assessment of pleiotropy, enhancing current analytic practice. © The Author 2017. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  9. Generalized partially linear single-index model for zero-inflated count data.

    Science.gov (United States)

    Wang, Xiaoguang; Zhang, Jun; Yu, Liang; Yin, Guosheng

    2015-02-28

    Count data often arise in biomedical studies, while there could be a special feature with excessive zeros in the observed counts. The zero-inflated Poisson model provides a natural approach to accounting for the excessive zero counts. In the semiparametric framework, we propose a generalized partially linear single-index model for the mean of the Poisson component, the probability of zero, or both. We develop the estimation and inference procedure via a profile maximum likelihood method. Under some mild conditions, we establish the asymptotic properties of the profile likelihood estimators. The finite sample performance of the proposed method is demonstrated by simulation studies, and the new model is illustrated with a medical care dataset. Copyright © 2014 John Wiley & Sons, Ltd.

  10. Boundary Lax pairs from non-ultra-local Poisson algebras

    International Nuclear Information System (INIS)

    Avan, Jean; Doikou, Anastasia

    2009-01-01

    We consider non-ultra-local linear Poisson algebras on a continuous line. Suitable combinations of representations of these algebras yield representations of novel generalized linear Poisson algebras or 'boundary' extensions. They are parametrized by a boundary scalar matrix and depend, in addition, on the choice of an antiautomorphism. The new algebras are the classical-linear counterparts of the known quadratic quantum boundary algebras. For any choice of parameters, the non-ultra-local contribution of the original Poisson algebra disappears. We also systematically construct the associated classical Lax pair. The classical boundary principal chiral model is examined as a physical example.

  11. Asymptotics for generalized piecewise linear histograms

    Czech Academy of Sciences Publication Activity Database

    Berlinet, A.; Hobza, Tomáš; Vajda, Igor

    2002-01-01

    Roč. 34, č. 3 (2002), s. 3-19 ISSN 0041-9184 R&D Projects: GA ČR GA102/99/1137 Institutional research plan: CEZ:AV0Z1075907 Keywords : nonparametric density estimation * histogram * piecewise linear histogram Subject RIV: BB - Applied Statistics, Operational Research

  12. Stochastic foundations of undulatory transport phenomena: generalized Poisson-Kac processes—part II Irreversibility, norms and entropies

    Science.gov (United States)

    Giona, Massimiliano; Brasiello, Antonio; Crescitelli, Silvestro

    2017-08-01

    In this second part, we analyze the dissipation properties of generalized Poisson-Kac (GPK) processes, considering the decay of suitable L 2-norms and the definition of entropy functions. In both cases, consistent energy dissipation and entropy functions depend on the whole system of primitive statistical variables, the partial probability density functions \\{ p_α({x}, t) \\}α=1N , while the corresponding energy dissipation and entropy functions based on the overall probability density p({x}, t) do not satisfy monotonicity requirements as a function of time. These results provide new insights on the theory of Markov operators associated with irreversible stochastic dynamics. Examples from chaotic advection (standard map coupled to stochastic GPK processes) illustrate this phenomenon. Some complementary physical issues are also addressed: the ergodicity breaking in the presence of attractive potentials, and the use of GPK perturbations to mollify stochastic field equations.

  13. Predictors of the number of under-five malnourished children in Bangladesh: application of the generalized poisson regression model.

    Science.gov (United States)

    Islam, Mohammad Mafijul; Alam, Morshed; Tariquzaman, Md; Kabir, Mohammad Alamgir; Pervin, Rokhsona; Begum, Munni; Khan, Md Mobarak Hossain

    2013-01-08

    Malnutrition is one of the principal causes of child mortality in developing countries including Bangladesh. According to our knowledge, most of the available studies, that addressed the issue of malnutrition among under-five children, considered the categorical (dichotomous/polychotomous) outcome variables and applied logistic regression (binary/multinomial) to find their predictors. In this study malnutrition variable (i.e. outcome) is defined as the number of under-five malnourished children in a family, which is a non-negative count variable. The purposes of the study are (i) to demonstrate the applicability of the generalized Poisson regression (GPR) model as an alternative of other statistical methods and (ii) to find some predictors of this outcome variable. The data is extracted from the Bangladesh Demographic and Health Survey (BDHS) 2007. Briefly, this survey employs a nationally representative sample which is based on a two-stage stratified sample of households. A total of 4,460 under-five children is analysed using various statistical techniques namely Chi-square test and GPR model. The GPR model (as compared to the standard Poisson regression and negative Binomial regression) is found to be justified to study the above-mentioned outcome variable because of its under-dispersion (variance variable namely mother's education, father's education, wealth index, sanitation status, source of drinking water, and total number of children ever born to a woman. Consistencies of our findings in light of many other studies suggest that the GPR model is an ideal alternative of other statistical models to analyse the number of under-five malnourished children in a family. Strategies based on significant predictors may improve the nutritional status of children in Bangladesh.

  14. Generalized Multicarrier CDMA: Unification and Linear Equalization

    Directory of Open Access Journals (Sweden)

    Wang Zhengdao

    2005-01-01

    Full Text Available Relying on block-symbol spreading and judicious design of user codes, this paper builds on the generalized multicarrier (GMC quasisynchronous CDMA system that is capable of multiuser interference (MUI elimination and intersymbol interference (ISI suppression with guaranteed symbol recovery, regardless of the wireless frequency-selective channels. GMC-CDMA affords an all-digital unifying framework, which encompasses single-carrier and several multicarrier (MC CDMA systems. Besides the unifying framework, it is shown that GMC-CDMA offers flexibility both in full load (maximum number of users allowed by the available bandwidth and in reduced load settings. A novel blind channel estimation algorithm is also derived. Analytical evaluation and simulations illustrate the superior error performance and flexibility of uncoded GMC-CDMA over competing MC-CDMA alternatives especially in the presence of uplink multipath channels.

  15. Analysis on Poisson and Gamma spaces

    OpenAIRE

    Kondratiev, Yuri; Silva, Jose Luis; Streit, Ludwig; Us, Georgi

    1999-01-01

    We study the spaces of Poisson, compound Poisson and Gamma noises as special cases of a general approach to non-Gaussian white noise calculus, see \\cite{KSS96}. We use a known unitary isomorphism between Poisson and compound Poisson spaces in order to transport analytic structures from Poisson space to compound Poisson space. Finally we study a Fock type structure of chaos decomposition on Gamma space.

  16. Centering, Scale Indeterminacy, and Differential Item Functioning Detection in Hierarchical Generalized Linear and Generalized Linear Mixed Models

    Science.gov (United States)

    Cheong, Yuk Fai; Kamata, Akihito

    2013-01-01

    In this article, we discuss and illustrate two centering and anchoring options available in differential item functioning (DIF) detection studies based on the hierarchical generalized linear and generalized linear mixed modeling frameworks. We compared and contrasted the assumptions of the two options, and examined the properties of their DIF…

  17. Fractional Poisson Fields and Martingales

    Science.gov (United States)

    Aletti, Giacomo; Leonenko, Nikolai; Merzbach, Ely

    2018-01-01

    We present new properties for the Fractional Poisson process (FPP) and the Fractional Poisson field on the plane. A martingale characterization for FPPs is given. We extend this result to Fractional Poisson fields, obtaining some other characterizations. The fractional differential equations are studied. We consider a more general Mixed-Fractional Poisson process and show that this process is the stochastic solution of a system of fractional differential-difference equations. Finally, we give some simulations of the Fractional Poisson field on the plane.

  18. Fractional Poisson Fields and Martingales

    Science.gov (United States)

    Aletti, Giacomo; Leonenko, Nikolai; Merzbach, Ely

    2018-02-01

    We present new properties for the Fractional Poisson process (FPP) and the Fractional Poisson field on the plane. A martingale characterization for FPPs is given. We extend this result to Fractional Poisson fields, obtaining some other characterizations. The fractional differential equations are studied. We consider a more general Mixed-Fractional Poisson process and show that this process is the stochastic solution of a system of fractional differential-difference equations. Finally, we give some simulations of the Fractional Poisson field on the plane.

  19. Generalized Linear Models with Applications in Engineering and the Sciences

    CERN Document Server

    Myers, Raymond H; Vining, G Geoffrey; Robinson, Timothy J

    2012-01-01

    Praise for the First Edition "The obvious enthusiasm of Myers, Montgomery, and Vining and their reliance on their many examples as a major focus of their pedagogy make Generalized Linear Models a joy to read. Every statistician working in any area of applied science should buy it and experience the excitement of these new approaches to familiar activities."-Technometrics Generalized Linear Models: With Applications in Engineering and the Sciences, Second Edition continues to provide a clear introduction to the theoretical foundations and key applications of generalized linear models (GLMs). Ma

  20. Minimal solution of general dual fuzzy linear systems

    International Nuclear Information System (INIS)

    Abbasbandy, S.; Otadi, M.; Mosleh, M.

    2008-01-01

    Fuzzy linear systems of equations, play a major role in several applications in various area such as engineering, physics and economics. In this paper, we investigate the existence of a minimal solution of general dual fuzzy linear equation systems. Two necessary and sufficient conditions for the minimal solution existence are given. Also, some examples in engineering and economic are considered

  1. Testing Parametric versus Semiparametric Modelling in Generalized Linear Models

    NARCIS (Netherlands)

    Härdle, W.K.; Mammen, E.; Müller, M.D.

    1996-01-01

    We consider a generalized partially linear model E(Y|X,T) = G{X'b + m(T)} where G is a known function, b is an unknown parameter vector, and m is an unknown function.The paper introduces a test statistic which allows to decide between a parametric and a semiparametric model: (i) m is linear, i.e.

  2. Practical likelihood analysis for spatial generalized linear mixed models

    DEFF Research Database (Denmark)

    Bonat, W. H.; Ribeiro, Paulo Justiniano

    2016-01-01

    , respectively, examples of binomial and count datasets modeled by spatial generalized linear mixed models. Our results show that the Laplace approximation provides similar estimates to Markov Chain Monte Carlo likelihood, Monte Carlo expectation maximization, and modified Laplace approximation. Some advantages...

  3. Generalized linear model for mapping discrete trait loci implemented with LASSO algorithm.

    Directory of Open Access Journals (Sweden)

    Jun Xing

    Full Text Available Generalized estimating equation (GEE algorithm under a heterogeneous residual variance model is an extension of the iteratively reweighted least squares (IRLS method for continuous traits to discrete traits. In contrast to mixture model-based expectation-maximization (EM algorithm, the GEE algorithm can well detect quantitative trait locus (QTL, especially large effect QTLs located in large marker intervals in the manner of high computing speed. Based on a single QTL model, however, the GEE algorithm has very limited statistical power to detect multiple QTLs because of ignoring other linked QTLs. In this study, the fast least absolute shrinkage and selection operator (LASSO is derived for generalized linear model (GLM with all possible link functions. Under a heterogeneous residual variance model, the LASSO for GLM is used to iteratively estimate the non-zero genetic effects of those loci over entire genome. The iteratively reweighted LASSO is therefore extended to mapping QTL for discrete traits, such as ordinal, binary, and Poisson traits. The simulated and real data analyses are conducted to demonstrate the efficiency of the proposed method to simultaneously identify multiple QTLs for binary and Poisson traits as examples.

  4. Generalized linear model for mapping discrete trait loci implemented with LASSO algorithm.

    Science.gov (United States)

    Xing, Jun; Gao, Huijiang; Wu, Yang; Wu, Yani; Li, Hongwang; Yang, Runqing

    2014-01-01

    Generalized estimating equation (GEE) algorithm under a heterogeneous residual variance model is an extension of the iteratively reweighted least squares (IRLS) method for continuous traits to discrete traits. In contrast to mixture model-based expectation-maximization (EM) algorithm, the GEE algorithm can well detect quantitative trait locus (QTL), especially large effect QTLs located in large marker intervals in the manner of high computing speed. Based on a single QTL model, however, the GEE algorithm has very limited statistical power to detect multiple QTLs because of ignoring other linked QTLs. In this study, the fast least absolute shrinkage and selection operator (LASSO) is derived for generalized linear model (GLM) with all possible link functions. Under a heterogeneous residual variance model, the LASSO for GLM is used to iteratively estimate the non-zero genetic effects of those loci over entire genome. The iteratively reweighted LASSO is therefore extended to mapping QTL for discrete traits, such as ordinal, binary, and Poisson traits. The simulated and real data analyses are conducted to demonstrate the efficiency of the proposed method to simultaneously identify multiple QTLs for binary and Poisson traits as examples.

  5. Poisson branching point processes

    International Nuclear Information System (INIS)

    Matsuo, K.; Teich, M.C.; Saleh, B.E.A.

    1984-01-01

    We investigate the statistical properties of a special branching point process. The initial process is assumed to be a homogeneous Poisson point process (HPP). The initiating events at each branching stage are carried forward to the following stage. In addition, each initiating event independently contributes a nonstationary Poisson point process (whose rate is a specified function) located at that point. The additional contributions from all points of a given stage constitute a doubly stochastic Poisson point process (DSPP) whose rate is a filtered version of the initiating point process at that stage. The process studied is a generalization of a Poisson branching process in which random time delays are permitted in the generation of events. Particular attention is given to the limit in which the number of branching stages is infinite while the average number of added events per event of the previous stage is infinitesimal. In the special case when the branching is instantaneous this limit of continuous branching corresponds to the well-known Yule--Furry process with an initial Poisson population. The Poisson branching point process provides a useful description for many problems in various scientific disciplines, such as the behavior of electron multipliers, neutron chain reactions, and cosmic ray showers

  6. Thurstonian models for sensory discrimination tests as generalized linear models

    DEFF Research Database (Denmark)

    Brockhoff, Per B.; Christensen, Rune Haubo Bojesen

    2010-01-01

    as a so-called generalized linear model. The underlying sensory difference 6 becomes directly a parameter of the statistical model and the estimate d' and it's standard error becomes the "usual" output of the statistical analysis. The d' for the monadic A-NOT A method is shown to appear as a standard...... linear contrast in a generalized linear model using the probit link function. All methods developed in the paper are implemented in our free R-package sensR (http://www.cran.r-project.org/package=sensR/). This includes the basic power and sample size calculations for these four discrimination tests...

  7. From linear to generalized linear mixed models: A case study in repeated measures

    Science.gov (United States)

    Compared to traditional linear mixed models, generalized linear mixed models (GLMMs) can offer better correspondence between response variables and explanatory models, yielding more efficient estimates and tests in the analysis of data from designed experiments. Using proportion data from a designed...

  8. Interpreting Hierarchical Linear and Hierarchical Generalized Linear Models with Slopes as Outcomes

    Science.gov (United States)

    Tate, Richard

    2004-01-01

    Current descriptions of results from hierarchical linear models (HLM) and hierarchical generalized linear models (HGLM), usually based only on interpretations of individual model parameters, are incomplete in the presence of statistically significant and practically important "slopes as outcomes" terms in the models. For complete description of…

  9. Penalized maximum likelihood estimation for generalized linear point processes

    DEFF Research Database (Denmark)

    Hansen, Niels Richard

    2010-01-01

    A generalized linear point process is specified in terms of an intensity that depends upon a linear predictor process through a fixed non-linear function. We present a framework where the linear predictor is parametrized by a Banach space and give results on Gateaux differentiability of the log......-likelihood. Of particular interest is when the intensity is expressed in terms of a linear filter parametrized by a Sobolev space. Using that the Sobolev spaces are reproducing kernel Hilbert spaces we derive results on the representation of the penalized maximum likelihood estimator in a special case and the gradient...... of the negative log-likelihood in general. The latter is used to develop a descent algorithm in the Sobolev space. We conclude the paper by extensions to multivariate and additive model specifications. The methods are implemented in the R-package ppstat....

  10. Penalized maximum likelihood estimation for generalized linear point processes

    DEFF Research Database (Denmark)

    Hansen, Niels Richard

    2010-01-01

    A generalized linear point process is specified in terms of an intensity that depends upon a linear predictor process through a fixed non-linear function. We present a framework where the linear predictor is parametrized by a Banach space and give results on Gateaux differentiability of the log...... of the negative log-likelihood in general. The latter is used to develop a descent algorithm in the Sobolev space. We conclude the paper by extensions to multivariate and additive model specifications. The methods are implemented in the R-package ppstat.......-likelihood. Of particular interest is when the intensity is expressed in terms of a linear filter parametrized by a Sobolev space. Using that the Sobolev spaces are reproducing kernel Hilbert spaces we derive results on the representation of the penalized maximum likelihood estimator in a special case and the gradient...

  11. Generalized linear longitudinal mixed models with linear covariance structure and multiplicative random effects

    DEFF Research Database (Denmark)

    Holst, René; Jørgensen, Bent

    2015-01-01

    The paper proposes a versatile class of multiplicative generalized linear longitudinal mixed models (GLLMM) with additive dispersion components, based on explicit modelling of the covariance structure. The class incorporates a longitudinal structure into the random effects models and retains...

  12. About one non linear generalization of the compression reflection ...

    African Journals Online (AJOL)

    Both cases of stage and spiral iterations are considered. A geometrical interpretation of a convergence of a generalize method of iteration is brought, the case of stage and spiral iterations are considered. The formula for the non linear generalize compression reflection operator as a function from one variable is obtained.

  13. Extending the linear model with R generalized linear, mixed effects and nonparametric regression models

    CERN Document Server

    Faraway, Julian J

    2005-01-01

    Linear models are central to the practice of statistics and form the foundation of a vast range of statistical methodologies. Julian J. Faraway''s critically acclaimed Linear Models with R examined regression and analysis of variance, demonstrated the different methods available, and showed in which situations each one applies. Following in those footsteps, Extending the Linear Model with R surveys the techniques that grow from the regression model, presenting three extensions to that framework: generalized linear models (GLMs), mixed effect models, and nonparametric regression models. The author''s treatment is thoroughly modern and covers topics that include GLM diagnostics, generalized linear mixed models, trees, and even the use of neural networks in statistics. To demonstrate the interplay of theory and practice, throughout the book the author weaves the use of the R software environment to analyze the data of real examples, providing all of the R commands necessary to reproduce the analyses. All of the ...

  14. Testing for one Generalized Linear Single Order Parameter

    DEFF Research Database (Denmark)

    Ellegaard, Niels Langager; Christensen, Tage Emil; Dyre, Jeppe

    work the order parameter may be chosen to have a non-exponential relaxation. The model predictions contradict the general consensus of the properties of viscous liquids in two ways: (i) The model predicts that following a linear isobaric temperature step, the normalized volume and entalpy relaxation......We examine a linear single order parameter model for thermoviscoelastic relaxation in viscous liquids, allowing for a distribution of relaxation times. In this model the relaxation of volume and entalpy is completely described by the relaxation of one internal order parameter. In contrast to prior...... functions are identical. This assumption conflicts with some (but not all) reports, utilizing the Tool-Narayanaswamy formalism to extrapolate from non-linear measurements to the linear regime. (ii) The model predicts that the theoretical "linear Prigogine-Defay" ratio is one. This ratio has never been...

  15. A Matrix Approach for General Higher Order Linear Recurrences

    Science.gov (United States)

    2011-01-01

    properties of linear recurrences (such as the well-known Fibonacci and Pell sequences). In [2], Er defined k linear recurring sequences of order at...the nth term of the ith generalized order-k Fibonacci sequence. Communicated by Lee See Keong. Received: March 26, 2009; Revised: August 28, 2009...Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject

  16. Estimation and variable selection for generalized additive partial linear models

    KAUST Repository

    Wang, Li

    2011-08-01

    We study generalized additive partial linear models, proposing the use of polynomial spline smoothing for estimation of nonparametric functions, and deriving quasi-likelihood based estimators for the linear parameters. We establish asymptotic normality for the estimators of the parametric components. The procedure avoids solving large systems of equations as in kernel-based procedures and thus results in gains in computational simplicity. We further develop a class of variable selection procedures for the linear parameters by employing a nonconcave penalized quasi-likelihood, which is shown to have an asymptotic oracle property. Monte Carlo simulations and an empirical example are presented for illustration. © Institute of Mathematical Statistics, 2011.

  17. Uniaxial Negative Thermal Expansion, Negative Linear Compressibility, and Negative Poisson's Ratio Induced by Specific Topology in Zn[Au(CN)2]2.

    Science.gov (United States)

    Wang, Lei; Luo, Hubin; Deng, Shenghua; Sun, Ying; Wang, Cong

    2017-12-18

    The well-known idea of "structure determines properties" can be understood profoundly in the case of hexagonal zinc dicyanometalate. Using density functional theory (DFT) calculations, we show the uniaxial negative thermal expansion (NTE) and negative linear compressibility (NLC) properties of Zn[Au(CN) 2 ] 2 . The temperature dependence of phonon frequencies within the quasi-harmonic approximation (QHA) is investigated. The abnormal phonon hardening (frequency increase on heating) is detected in the ranges of 0-225, 320-345, and 410-430 cm -1 , which can be indicative of the unusual physical properties of Zn[Au(CN) 2 ] 2 . Due to the significance of low-energy phonon frequencies in Zn[Au(CN) 2 ] 2 , in this work, the corresponding vibrational mode of the lowest-frequency optical phonon at the zone center is analyzed. The specific topology of a springlike framework that will produce the effects of a compressed spring on heating and an extended spring under hydrostatic pressure is identified and leads to the coexistence of uniaxial-NTE and NLC behaviors in Zn[Au(CN) 2 ] 2 . The distinguishing phonon group velocity along the a axis and c axis facilitates different responses for both the axes under temperature and hydrostatic pressure field. Through an analysis and visualization of the spatial dependence of elastic tensors, it is found that a negative Poisson's ratio (NPR) is presented in all projection planes due to the specific topology.

  18. Dynamic generalized linear models for monitoring endemic diseases

    DEFF Research Database (Denmark)

    Lopes Antunes, Ana Carolina; Jensen, Dan; Hisham Beshara Halasa, Tariq

    2016-01-01

    The objective was to use a Dynamic Generalized Linear Model (DGLM) based on abinomial distribution with a linear trend, for monitoring the PRRS (Porcine Reproductive and Respiratory Syndrome sero-prevalence in Danish swine herds. The DGLM was described and its performance for monitoring control...... in sero-prevalence. Based on this, it was possible to detect variations in the growth model component. This study is a proof-of-concept, demonstrating the use of DGLMs for monitoring endemic diseases. In addition, the principles stated might be useful in general research on monitoring and surveillance...

  19. The linear model and hypothesis a general unifying theory

    CERN Document Server

    Seber, George

    2015-01-01

    This book provides a concise and integrated overview of hypothesis testing in four important subject areas, namely linear and nonlinear models, multivariate analysis, and large sample theory. The approach used is a geometrical one based on the concept of projections and their associated idempotent matrices, thus largely avoiding the need to involve matrix ranks. It is shown that all the hypotheses encountered are either linear or asymptotically linear, and that all the underlying models used are either exactly or asymptotically linear normal models. This equivalence can be used, for example, to extend the concept of orthogonality in the analysis of variance to other models, and to show that the asymptotic equivalence of the likelihood ratio, Wald, and Score (Lagrange Multiplier) hypothesis tests generally applies.

  20. An implicit spectral formula for generalized linear Schroedinger equations

    International Nuclear Information System (INIS)

    Schulze-Halberg, A.; Garcia-Ravelo, J.; Pena Gil, Jose Juan

    2009-01-01

    We generalize the semiclassical Bohr–Sommerfeld quantization rule to an exact, implicit spectral formula for linear, generalized Schroedinger equations admitting a discrete spectrum. Special cases include the position-dependent mass Schroedinger equation or the Schroedinger equation for weighted energy. Requiring knowledge of the potential and the solution associated with the lowest spectral value, our formula predicts the complete spectrum in its exact form. (author)

  1. Algorithms for Generalized Cluster-wise Linear Regression

    OpenAIRE

    Park, Young Woong; Jiang, Yan; Klabjan, Diego; Williams, Loren

    2016-01-01

    Cluster-wise linear regression (CLR), a clustering problem intertwined with regression, is to find clusters of entities such that the overall sum of squared errors from regressions performed over these clusters is minimized, where each cluster may have different variances. We generalize the CLR problem by allowing each entity to have more than one observation, and refer to it as generalized CLR. We propose an exact mathematical programming based approach relying on column generation, a column...

  2. Neural Generalized Predictive Control of a non-linear Process

    DEFF Research Database (Denmark)

    Sørensen, Paul Haase; Nørgård, Peter Magnus; Ravn, Ole

    1998-01-01

    qualities. The controller is a non-linear version of the well-known generalized predictive controller developed in linear control theory. It involves minimization of a cost function which in the present case has to be done numerically. Therefore, we develop the numerical algorithms necessary in substantial......The use of neural network in non-linear control is made difficult by the fact the stability and robustness is not guaranteed and that the implementation in real time is non-trivial. In this paper we introduce a predictive controller based on a neural network model which has promising stability...... detail and discuss the implementation difficulties. The neural generalized predictive controller is tested on a pneumatic servo sys-tem....

  3. New Implicit General Linear Method | Ibrahim | Journal of the ...

    African Journals Online (AJOL)

    A New implicit general linear method is designed for the numerical olution of stiff differential Equations. The coefficients matrix is derived from the stability function. The method combines the single-implicitness or diagonal implicitness with property that the first two rows are implicit and third and fourth row are explicit.

  4. Hierarchical Generalized Linear Models for the Analysis of Judge Ratings

    Science.gov (United States)

    Muckle, Timothy J.; Karabatsos, George

    2009-01-01

    It is known that the Rasch model is a special two-level hierarchical generalized linear model (HGLM). This article demonstrates that the many-faceted Rasch model (MFRM) is also a special case of the two-level HGLM, with a random intercept representing examinee ability on a test, and fixed effects for the test items, judges, and possibly other…

  5. A MIXTURE LIKELIHOOD APPROACH FOR GENERALIZED LINEAR-MODELS

    NARCIS (Netherlands)

    WEDEL, M; DESARBO, WS

    1995-01-01

    A mixture model approach is developed that simultaneously estimates the posterior membership probabilities of observations to a number of unobservable groups or latent classes, and the parameters of a generalized linear model which relates the observations, distributed according to some member of

  6. Confidence Intervals for Assessing Heterogeneity in Generalized Linear Mixed Models

    Science.gov (United States)

    Wagler, Amy E.

    2014-01-01

    Generalized linear mixed models are frequently applied to data with clustered categorical outcomes. The effect of clustering on the response is often difficult to practically assess partly because it is reported on a scale on which comparisons with regression parameters are difficult to make. This article proposes confidence intervals for…

  7. Torus quotients of homogeneous spaces of the general linear group ...

    Indian Academy of Sciences (India)

    ... Refresher Courses · Symposia · Live Streaming. Home; Journals; Proceedings – Mathematical Sciences; Volume 119; Issue 1. Torus Quotients of Homogeneous Spaces of the General Linear Group and the Standard Representation of Certain Symmetric Groups. S S Kannan Pranab Sardar. Volume 119 Issue 1 February ...

  8. Validity of tests under covariate-adaptive biased coin randomization and generalized linear models.

    Science.gov (United States)

    Shao, Jun; Yu, Xinxin

    2013-12-01

    Some covariate-adaptive randomization methods have been used in clinical trials for a long time, but little theoretical work has been done about testing hypotheses under covariate-adaptive randomization until Shao et al. (2010) who provided a theory with detailed discussion for responses under linear models. In this article, we establish some asymptotic results for covariate-adaptive biased coin randomization under generalized linear models with possibly unknown link functions. We show that the simple t-test without using any covariate is conservative under covariate-adaptive biased coin randomization in terms of its Type I error rate, and that a valid test using the bootstrap can be constructed. This bootstrap test, utilizing covariates in the randomization scheme, is shown to be asymptotically as efficient as Wald's test correctly using covariates in the analysis. Thus, the efficiency loss due to not using covariates in the analysis can be recovered by utilizing covariates in covariate-adaptive biased coin randomization. Our theory is illustrated with two most popular types of discrete outcomes, binary responses and event counts under the Poisson model, and exponentially distributed continuous responses. We also show that an alternative simple test without using any covariate under the Poisson model has an inflated Type I error rate under simple randomization, but is valid under covariate-adaptive biased coin randomization. Effects on the validity of tests due to model misspecification is also discussed. Simulation studies about the Type I errors and powers of several tests are presented for both discrete and continuous responses. © 2013, The International Biometric Society.

  9. Regularization Paths for Generalized Linear Models via Coordinate Descent

    Directory of Open Access Journals (Sweden)

    Jerome Friedman

    2010-02-01

    Full Text Available We develop fast algorithms for estimation of generalized linear models with convex penalties. The models include linear regression, two-class logistic regression, and multi- nomial regression problems while the penalties include ℓ1 (the lasso, ℓ2 (ridge regression and mixtures of the two (the elastic net. The algorithms use cyclical coordinate descent, computed along a regularization path. The methods can handle large problems and can also deal efficiently with sparse features. In comparative timings we find that the new algorithms are considerably faster than competing methods.

  10. The negative binomial-Lindley generalized linear model: characteristics and application using crash data.

    Science.gov (United States)

    Geedipally, Srinivas Reddy; Lord, Dominique; Dhavala, Soma Sekhar

    2012-03-01

    There has been a considerable amount of work devoted by transportation safety analysts to the development and application of new and innovative models for analyzing crash data. One important characteristic about crash data that has been documented in the literature is related to datasets that contained a large amount of zeros and a long or heavy tail (which creates highly dispersed data). For such datasets, the number of sites where no crash is observed is so large that traditional distributions and regression models, such as the Poisson and Poisson-gamma or negative binomial (NB) models cannot be used efficiently. To overcome this problem, the NB-Lindley (NB-L) distribution has recently been introduced for analyzing count data that are characterized by excess zeros. The objective of this paper is to document the application of a NB generalized linear model with Lindley mixed effects (NB-L GLM) for analyzing traffic crash data. The study objective was accomplished using simulated and observed datasets. The simulated dataset was used to show the general performance of the model. The model was then applied to two datasets based on observed data. One of the dataset was characterized by a large amount of zeros. The NB-L GLM was compared with the NB and zero-inflated models. Overall, the research study shows that the NB-L GLM not only offers superior performance over the NB and zero-inflated models when datasets are characterized by a large number of zeros and a long tail, but also when the crash dataset is highly dispersed. Published by Elsevier Ltd.

  11. Computation of Optimal Monotonicity Preserving General Linear Methods

    KAUST Repository

    Ketcheson, David I.

    2009-07-01

    Monotonicity preserving numerical methods for ordinary differential equations prevent the growth of propagated errors and preserve convex boundedness properties of the solution. We formulate the problem of finding optimal monotonicity preserving general linear methods for linear autonomous equations, and propose an efficient algorithm for its solution. This algorithm reliably finds optimal methods even among classes involving very high order accuracy and that use many steps and/or stages. The optimality of some recently proposed methods is verified, and many more efficient methods are found. We use similar algorithms to find optimal strong stability preserving linear multistep methods of both explicit and implicit type, including methods for hyperbolic PDEs that use downwind-biased operators.

  12. Modified Regression Correlation Coefficient for Poisson Regression Model

    Science.gov (United States)

    Kaengthong, Nattacha; Domthong, Uthumporn

    2017-09-01

    This study gives attention to indicators in predictive power of the Generalized Linear Model (GLM) which are widely used; however, often having some restrictions. We are interested in regression correlation coefficient for a Poisson regression model. This is a measure of predictive power, and defined by the relationship between the dependent variable (Y) and the expected value of the dependent variable given the independent variables [E(Y|X)] for the Poisson regression model. The dependent variable is distributed as Poisson. The purpose of this research was modifying regression correlation coefficient for Poisson regression model. We also compare the proposed modified regression correlation coefficient with the traditional regression correlation coefficient in the case of two or more independent variables, and having multicollinearity in independent variables. The result shows that the proposed regression correlation coefficient is better than the traditional regression correlation coefficient based on Bias and the Root Mean Square Error (RMSE).

  13. Enhanced group analysis of a semi linear generalization of a general bond-pricing equation

    Science.gov (United States)

    Bozhkov, Y.; Dimas, S.

    2018-01-01

    The enhanced group classification of a semi linear generalization of a general bond-pricing equation is carried out by harnessing the underlying equivalence and additional equivalence transformations. We employ that classification to unearth the particular cases with a larger Lie algebra than the general case and use them to find non trivial invariant solutions under the terminal and the barrier option condition.

  14. Estimating classification images with generalized linear and additive models.

    Science.gov (United States)

    Knoblauch, Kenneth; Maloney, Laurence T

    2008-12-22

    Conventional approaches to modeling classification image data can be described in terms of a standard linear model (LM). We show how the problem can be characterized as a Generalized Linear Model (GLM) with a Bernoulli distribution. We demonstrate via simulation that this approach is more accurate in estimating the underlying template in the absence of internal noise. With increasing internal noise, however, the advantage of the GLM over the LM decreases and GLM is no more accurate than LM. We then introduce the Generalized Additive Model (GAM), an extension of GLM that can be used to estimate smooth classification images adaptively. We show that this approach is more robust to the presence of internal noise, and finally, we demonstrate that GAM is readily adapted to estimation of higher order (nonlinear) classification images and to testing their significance.

  15. Penalized Estimation in Large-Scale Generalized Linear Array Models

    DEFF Research Database (Denmark)

    Lund, Adam; Vincent, Martin; Hansen, Niels Richard

    2017-01-01

    Large-scale generalized linear array models (GLAMs) can be challenging to fit. Computation and storage of its tensor product design matrix can be impossible due to time and memory constraints, and previously considered design matrix free algorithms do not scale well with the dimension of the para......Large-scale generalized linear array models (GLAMs) can be challenging to fit. Computation and storage of its tensor product design matrix can be impossible due to time and memory constraints, and previously considered design matrix free algorithms do not scale well with the dimension...... of the parameter vector. A new design matrix free algorithm is proposed for computing the penalized maximum likelihood estimate for GLAMs, which, in particular, handles nondifferentiable penalty functions. The proposed algorithm is implemented and available via the R package glamlasso. It combines several ideas...

  16. A Unified Bayesian Inference Framework for Generalized Linear Models

    Science.gov (United States)

    Meng, Xiangming; Wu, Sheng; Zhu, Jiang

    2018-03-01

    In this letter, we present a unified Bayesian inference framework for generalized linear models (GLM) which iteratively reduces the GLM problem to a sequence of standard linear model (SLM) problems. This framework provides new perspectives on some established GLM algorithms derived from SLM ones and also suggests novel extensions for some other SLM algorithms. Specific instances elucidated under such framework are the GLM versions of approximate message passing (AMP), vector AMP (VAMP), and sparse Bayesian learning (SBL). It is proved that the resultant GLM version of AMP is equivalent to the well-known generalized approximate message passing (GAMP). Numerical results for 1-bit quantized compressed sensing (CS) demonstrate the effectiveness of this unified framework.

  17. A Non-Gaussian Spatial Generalized Linear Latent Variable Model

    KAUST Repository

    Irincheeva, Irina

    2012-08-03

    We consider a spatial generalized linear latent variable model with and without normality distributional assumption on the latent variables. When the latent variables are assumed to be multivariate normal, we apply a Laplace approximation. To relax the assumption of marginal normality in favor of a mixture of normals, we construct a multivariate density with Gaussian spatial dependence and given multivariate margins. We use the pairwise likelihood to estimate the corresponding spatial generalized linear latent variable model. The properties of the resulting estimators are explored by simulations. In the analysis of an air pollution data set the proposed methodology uncovers weather conditions to be a more important source of variability than air pollution in explaining all the causes of non-accidental mortality excluding accidents. © 2012 International Biometric Society.

  18. A general method for enclosing solutions of interval linear equations

    Czech Academy of Sciences Publication Activity Database

    Rohn, Jiří

    2012-01-01

    Roč. 6, č. 4 (2012), s. 709-717 ISSN 1862-4472 R&D Projects: GA ČR GA201/09/1957; GA ČR GC201/08/J020 Institutional research plan: CEZ:AV0Z10300504 Keywords : interval linear equations * solution set * enclosure * absolute value inequality Subject RIV: BA - General Mathematics Impact factor: 1.654, year: 2012

  19. Linear relativistic gyrokinetic equation in general magnetically confined plasmas

    International Nuclear Information System (INIS)

    Tsai, S.T.; Van Dam, J.W.; Chen, L.

    1983-08-01

    The gyrokinetic formalism for linear electromagnetic waves of arbitrary frequency in general magnetic-field configurations is extended to include full relativistic effects. The derivation employs the small adiabaticity parameter rho/L 0 where rho is the Larmor radius and L 0 the equilibrium scale length. The effects of the plasma and magnetic field inhomogeneities and finite Larmor-radii effects are also contained

  20. Canonical perturbation theory in linearized general relativity theory

    International Nuclear Information System (INIS)

    Gonzales, R.; Pavlenko, Yu.G.

    1986-01-01

    Canonical perturbation theory in linearized general relativity theory is developed. It is shown that the evolution of arbitrary dynamic value, conditioned by the interaction of particles, gravitation and electromagnetic fields, can be presented in the form of a series, each member of it corresponding to the contribution of certain spontaneous or induced process. The main concepts of the approach are presented in the approximation of a weak gravitational field

  1. General treatment of a non-linear gauge condition

    International Nuclear Information System (INIS)

    Malleville, C.

    1982-06-01

    A non linear gauge condition is presented in the frame of a non abelian gauge theory broken with the Higgs mechanism. It is shown that this condition already introduced for the standard SU(2) x U(1) model can be generalized for any gauge model with the same type of simplification, namely the suppression of any coupling of the form: massless gauge boson, massive gauge boson, unphysical Higgs [fr

  2. Poisson Mixture Regression Models for Heart Disease Prediction

    Science.gov (United States)

    Erol, Hamza

    2016-01-01

    Early heart disease control can be achieved by high disease prediction and diagnosis efficiency. This paper focuses on the use of model based clustering techniques to predict and diagnose heart disease via Poisson mixture regression models. Analysis and application of Poisson mixture regression models is here addressed under two different classes: standard and concomitant variable mixture regression models. Results show that a two-component concomitant variable Poisson mixture regression model predicts heart disease better than both the standard Poisson mixture regression model and the ordinary general linear Poisson regression model due to its low Bayesian Information Criteria value. Furthermore, a Zero Inflated Poisson Mixture Regression model turned out to be the best model for heart prediction over all models as it both clusters individuals into high or low risk category and predicts rate to heart disease componentwise given clusters available. It is deduced that heart disease prediction can be effectively done by identifying the major risks componentwise using Poisson mixture regression model. PMID:27999611

  3. MCMC Methods for Multi-Response Generalized Linear Mixed Models: The MCMCglmm R Package

    Directory of Open Access Journals (Sweden)

    Jarrod Had

    2010-02-01

    Full Text Available Generalized linear mixed models provide a flexible framework for modeling a range of data, although with non-Gaussian response variables the likelihood cannot be obtained in closed form. Markov chain Monte Carlo methods solve this problem by sampling from a series of simpler conditional distributions that can be evaluated. The R package MCMCglmm implements such an algorithm for a range of model fitting problems. More than one response variable can be analyzed simultaneously, and these variables are allowed to follow Gaussian, Poisson, multi(binominal, exponential, zero-inflated and censored distributions. A range of variance structures are permitted for the random effects, including interactions with categorical or continuous variables (i.e., random regression, and more complicated variance structures that arise through shared ancestry, either through a pedigree or through a phylogeny. Missing values are permitted in the response variable(s and data can be known up to some level of measurement error as in meta-analysis. All simu- lation is done in C/ C++ using the CSparse library for sparse linear systems.

  4. Classification images and bubbles images in the generalized linear model.

    Science.gov (United States)

    Murray, Richard F

    2012-07-09

    Classification images and bubbles images are psychophysical tools that use stimulus noise to investigate what features people use to make perceptual decisions. Previous work has shown that classification images can be estimated using the generalized linear model (GLM), and here I show that this is true for bubbles images as well. Expressing the two approaches in terms of a single statistical model clarifies their relationship to one another, makes it possible to measure classification images and bubbles images simultaneously, and allows improvements developed for one method to be used with the other.

  5. Generalized constraint neural network regression model subject to linear priors.

    Science.gov (United States)

    Qu, Ya-Jun; Hu, Bao-Gang

    2011-12-01

    This paper is reports an extension of our previous investigations on adding transparency to neural networks. We focus on a class of linear priors (LPs), such as symmetry, ranking list, boundary, monotonicity, etc., which represent either linear-equality or linear-inequality priors. A generalized constraint neural network-LPs (GCNN-LPs) model is studied. Unlike other existing modeling approaches, the GCNN-LP model exhibits its advantages. First, any LP is embedded by an explicitly structural mode, which may add a higher degree of transparency than using a pure algorithm mode. Second, a direct elimination and least squares approach is adopted to study the model, which produces better performances in both accuracy and computational cost over the Lagrange multiplier techniques in experiments. Specific attention is paid to both "hard (strictly satisfied)" and "soft (weakly satisfied)" constraints for regression problems. Numerical investigations are made on synthetic examples as well as on the real-world datasets. Simulation results demonstrate the effectiveness of the proposed modeling approach in comparison with other existing approaches.

  6. Generalized space and linear momentum operators in quantum mechanics

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Bruno G. da, E-mail: bruno.costa@ifsertao-pe.edu.br [Instituto Federal de Educação, Ciência e Tecnologia do Sertão Pernambucano, Campus Petrolina, BR 407, km 08, 56314-520 Petrolina, Pernambuco (Brazil); Instituto de Física, Universidade Federal da Bahia, R. Barão de Jeremoabo s/n, 40170-115 Salvador, Bahia (Brazil); Borges, Ernesto P., E-mail: ernesto@ufba.br [Instituto de Física, Universidade Federal da Bahia, R. Barão de Jeremoabo s/n, 40170-115 Salvador, Bahia (Brazil)

    2014-06-15

    We propose a modification of a recently introduced generalized translation operator, by including a q-exponential factor, which implies in the definition of a Hermitian deformed linear momentum operator p{sup ^}{sub q}, and its canonically conjugate deformed position operator x{sup ^}{sub q}. A canonical transformation leads the Hamiltonian of a position-dependent mass particle to another Hamiltonian of a particle with constant mass in a conservative force field of a deformed phase space. The equation of motion for the classical phase space may be expressed in terms of the generalized dual q-derivative. A position-dependent mass confined in an infinite square potential well is shown as an instance. Uncertainty and correspondence principles are analyzed.

  7. Polymorphic Uncertain Linear Programming for Generalized Production Planning Problems

    Directory of Open Access Journals (Sweden)

    Xinbo Zhang

    2014-01-01

    Full Text Available A polymorphic uncertain linear programming (PULP model is constructed to formulate a class of generalized production planning problems. In accordance with the practical environment, some factors such as the consumption of raw material, the limitation of resource and the demand of product are incorporated into the model as parameters of interval and fuzzy subsets, respectively. Based on the theory of fuzzy interval program and the modified possibility degree for the order of interval numbers, a deterministic equivalent formulation for this model is derived such that a robust solution for the uncertain optimization problem is obtained. Case study indicates that the constructed model and the proposed solution are useful to search for an optimal production plan for the polymorphic uncertain generalized production planning problems.

  8. Generalized linear mixed model for segregation distortion analysis.

    Science.gov (United States)

    Zhan, Haimao; Xu, Shizhong

    2011-11-11

    Segregation distortion is a phenomenon that the observed genotypic frequencies of a locus fall outside the expected Mendelian segregation ratio. The main cause of segregation distortion is viability selection on linked marker loci. These viability selection loci can be mapped using genome-wide marker information. We developed a generalized linear mixed model (GLMM) under the liability model to jointly map all viability selection loci of the genome. Using a hierarchical generalized linear mixed model, we can handle the number of loci several times larger than the sample size. We used a dataset from an F(2) mouse family derived from the cross of two inbred lines to test the model and detected a major segregation distortion locus contributing 75% of the variance of the underlying liability. Replicated simulation experiments confirm that the power of viability locus detection is high and the false positive rate is low. Not only can the method be used to detect segregation distortion loci, but also used for mapping quantitative trait loci of disease traits using case only data in humans and selected populations in plants and animals.

  9. Background stratified Poisson regression analysis of cohort data.

    Science.gov (United States)

    Richardson, David B; Langholz, Bryan

    2012-03-01

    Background stratified Poisson regression is an approach that has been used in the analysis of data derived from a variety of epidemiologically important studies of radiation-exposed populations, including uranium miners, nuclear industry workers, and atomic bomb survivors. We describe a novel approach to fit Poisson regression models that adjust for a set of covariates through background stratification while directly estimating the radiation-disease association of primary interest. The approach makes use of an expression for the Poisson likelihood that treats the coefficients for stratum-specific indicator variables as 'nuisance' variables and avoids the need to explicitly estimate the coefficients for these stratum-specific parameters. Log-linear models, as well as other general relative rate models, are accommodated. This approach is illustrated using data from the Life Span Study of Japanese atomic bomb survivors and data from a study of underground uranium miners. The point estimate and confidence interval obtained from this 'conditional' regression approach are identical to the values obtained using unconditional Poisson regression with model terms for each background stratum. Moreover, it is shown that the proposed approach allows estimation of background stratified Poisson regression models of non-standard form, such as models that parameterize latency effects, as well as regression models in which the number of strata is large, thereby overcoming the limitations of previously available statistical software for fitting background stratified Poisson regression models.

  10. Background stratified Poisson regression analysis of cohort data

    International Nuclear Information System (INIS)

    Richardson, David B.; Langholz, Bryan

    2012-01-01

    Background stratified Poisson regression is an approach that has been used in the analysis of data derived from a variety of epidemiologically important studies of radiation-exposed populations, including uranium miners, nuclear industry workers, and atomic bomb survivors. We describe a novel approach to fit Poisson regression models that adjust for a set of covariates through background stratification while directly estimating the radiation-disease association of primary interest. The approach makes use of an expression for the Poisson likelihood that treats the coefficients for stratum-specific indicator variables as 'nuisance' variables and avoids the need to explicitly estimate the coefficients for these stratum-specific parameters. Log-linear models, as well as other general relative rate models, are accommodated. This approach is illustrated using data from the Life Span Study of Japanese atomic bomb survivors and data from a study of underground uranium miners. The point estimate and confidence interval obtained from this 'conditional' regression approach are identical to the values obtained using unconditional Poisson regression with model terms for each background stratum. Moreover, it is shown that the proposed approach allows estimation of background stratified Poisson regression models of non-standard form, such as models that parameterize latency effects, as well as regression models in which the number of strata is large, thereby overcoming the limitations of previously available statistical software for fitting background stratified Poisson regression models. (orig.)

  11. Background stratified Poisson regression analysis of cohort data

    Energy Technology Data Exchange (ETDEWEB)

    Richardson, David B. [University of North Carolina at Chapel Hill, Department of Epidemiology, School of Public Health, Chapel Hill, NC (United States); Langholz, Bryan [Keck School of Medicine, University of Southern California, Division of Biostatistics, Department of Preventive Medicine, Los Angeles, CA (United States)

    2012-03-15

    Background stratified Poisson regression is an approach that has been used in the analysis of data derived from a variety of epidemiologically important studies of radiation-exposed populations, including uranium miners, nuclear industry workers, and atomic bomb survivors. We describe a novel approach to fit Poisson regression models that adjust for a set of covariates through background stratification while directly estimating the radiation-disease association of primary interest. The approach makes use of an expression for the Poisson likelihood that treats the coefficients for stratum-specific indicator variables as 'nuisance' variables and avoids the need to explicitly estimate the coefficients for these stratum-specific parameters. Log-linear models, as well as other general relative rate models, are accommodated. This approach is illustrated using data from the Life Span Study of Japanese atomic bomb survivors and data from a study of underground uranium miners. The point estimate and confidence interval obtained from this 'conditional' regression approach are identical to the values obtained using unconditional Poisson regression with model terms for each background stratum. Moreover, it is shown that the proposed approach allows estimation of background stratified Poisson regression models of non-standard form, such as models that parameterize latency effects, as well as regression models in which the number of strata is large, thereby overcoming the limitations of previously available statistical software for fitting background stratified Poisson regression models. (orig.)

  12. Bayesian Subset Modeling for High-Dimensional Generalized Linear Models

    KAUST Repository

    Liang, Faming

    2013-06-01

    This article presents a new prior setting for high-dimensional generalized linear models, which leads to a Bayesian subset regression (BSR) with the maximum a posteriori model approximately equivalent to the minimum extended Bayesian information criterion model. The consistency of the resulting posterior is established under mild conditions. Further, a variable screening procedure is proposed based on the marginal inclusion probability, which shares the same properties of sure screening and consistency with the existing sure independence screening (SIS) and iterative sure independence screening (ISIS) procedures. However, since the proposed procedure makes use of joint information from all predictors, it generally outperforms SIS and ISIS in real applications. This article also makes extensive comparisons of BSR with the popular penalized likelihood methods, including Lasso, elastic net, SIS, and ISIS. The numerical results indicate that BSR can generally outperform the penalized likelihood methods. The models selected by BSR tend to be sparser and, more importantly, of higher prediction ability. In addition, the performance of the penalized likelihood methods tends to deteriorate as the number of predictors increases, while this is not significant for BSR. Supplementary materials for this article are available online. © 2013 American Statistical Association.

  13. Poisson integrators for Lie-Poisson structures on R3

    International Nuclear Information System (INIS)

    Song Lina

    2011-01-01

    This paper is concerned with the study of Poisson integrators. We are interested in Lie-Poisson systems on R 3 . First, we focus on Poisson integrators for constant Poisson systems and the transformations used for transforming Lie-Poisson structures to constant Poisson structures. Then, we construct local Poisson integrators for Lie-Poisson systems on R 3 . Finally, we present the results of numerical experiments for two Lie-Poisson systems and compare our Poisson integrators with other known methods.

  14. Developing a methodology to predict PM10 concentrations in urban areas using generalized linear models.

    Science.gov (United States)

    Garcia, J M; Teodoro, F; Cerdeira, R; Coelho, L M R; Kumar, Prashant; Carvalho, M G

    2016-09-01

    A methodology to predict PM10 concentrations in urban outdoor environments is developed based on the generalized linear models (GLMs). The methodology is based on the relationship developed between atmospheric concentrations of air pollutants (i.e. CO, NO2, NOx, VOCs, SO2) and meteorological variables (i.e. ambient temperature, relative humidity (RH) and wind speed) for a city (Barreiro) of Portugal. The model uses air pollution and meteorological data from the Portuguese monitoring air quality station networks. The developed GLM considers PM10 concentrations as a dependent variable, and both the gaseous pollutants and meteorological variables as explanatory independent variables. A logarithmic link function was considered with a Poisson probability distribution. Particular attention was given to cases with air temperatures both below and above 25°C. The best performance for modelled results against the measured data was achieved for the model with values of air temperature above 25°C compared with the model considering all ranges of air temperatures and with the model considering only temperature below 25°C. The model was also tested with similar data from another Portuguese city, Oporto, and results found to behave similarly. It is concluded that this model and the methodology could be adopted for other cities to predict PM10 concentrations when these data are not available by measurements from air quality monitoring stations or other acquisition means.

  15. dglars: An R Package to Estimate Sparse Generalized Linear Models

    Directory of Open Access Journals (Sweden)

    Luigi Augugliaro

    2014-09-01

    Full Text Available dglars is a publicly available R package that implements the method proposed in Augugliaro, Mineo, and Wit (2013, developed to study the sparse structure of a generalized linear model. This method, called dgLARS, is based on a differential geometrical extension of the least angle regression method proposed in Efron, Hastie, Johnstone, and Tibshirani (2004. The core of the dglars package consists of two algorithms implemented in Fortran 90 to efficiently compute the solution curve: a predictor-corrector algorithm, proposed in Augugliaro et al. (2013, and a cyclic coordinate descent algorithm, proposed in Augugliaro, Mineo, and Wit (2012. The latter algorithm, as shown here, is significantly faster than the predictor-corrector algorithm. For comparison purposes, we have implemented both algorithms.

  16. Analysis of Robust Quasi-deviances for Generalized Linear Models

    Directory of Open Access Journals (Sweden)

    Eva Cantoni

    2004-04-01

    Full Text Available Generalized linear models (McCullagh and Nelder 1989 are a popular technique for modeling a large variety of continuous and discrete data. They assume that the response variables Yi , for i = 1, . . . , n, come from a distribution belonging to the exponential family, such that E[Yi ] = ?i and V[Yi ] = V (?i , and that ?i = g(?i = xiT?, where ? ? IR p is the vector of parameters, xi ? IR p, and g(. is the link function. The non-robustness of the maximum likelihood and the maximum quasi-likelihood estimators has been studied extensively in the literature. For model selection, the classical analysis-of-deviance approach shares the same bad robustness properties. To cope with this, Cantoni and Ronchetti (2001 propose a robust approach based on robust quasi-deviance functions for estimation and variable selection. We refer to that paper for a deeper discussion and the review of the literature.

  17. Mixed Task and Data Parallel Executions in General Linear Methods

    Directory of Open Access Journals (Sweden)

    Thomas Rauber

    2007-01-01

    Full Text Available On many parallel target platforms it can be advantageous to implement parallel applications as a collection of multiprocessor tasks that are concurrently executed and are internally implemented with fine-grain SPMD parallelism. A class of applications which can benefit from this programming style are methods for solving systems of ordinary differential equations. Many recent solvers have been designed with an additional potential of method parallelism, but the actual effectiveness of mixed task and data parallelism depends on the specific communication and computation requirements imposed by the equation to be solved. In this paper we study mixed task and data parallel implementations for general linear methods realized using a library for multiprocessor task programming. Experiments on a number of different platforms show good efficiency results.

  18. Explicit estimating equations for semiparametric generalized linear latent variable models

    KAUST Repository

    Ma, Yanyuan

    2010-07-05

    We study generalized linear latent variable models without requiring a distributional assumption of the latent variables. Using a geometric approach, we derive consistent semiparametric estimators. We demonstrate that these models have a property which is similar to that of a sufficient complete statistic, which enables us to simplify the estimating procedure and explicitly to formulate the semiparametric estimating equations. We further show that the explicit estimators have the usual root n consistency and asymptotic normality. We explain the computational implementation of our method and illustrate the numerical performance of the estimators in finite sample situations via extensive simulation studies. The advantage of our estimators over the existing likelihood approach is also shown via numerical comparison. We employ the method to analyse a real data example from economics. © 2010 Royal Statistical Society.

  19. The Poisson aggregation process

    International Nuclear Information System (INIS)

    Eliazar, Iddo

    2016-01-01

    In this paper we introduce and analyze the Poisson Aggregation Process (PAP): a stochastic model in which a random collection of random balls is stacked over a general metric space. The scattering of the balls’ centers follows a general Poisson process over the metric space, and the balls’ radii are independent and identically distributed random variables governed by a general distribution. For each point of the metric space, the PAP counts the number of balls that are stacked over it. The PAP model is a highly versatile spatial counterpart of the temporal M/G/∞ model in queueing theory. The surface of the moon, scarred by circular meteor-impact craters, exemplifies the PAP model in two dimensions: the PAP counts the number of meteor-impacts that any given moon-surface point sustained. A comprehensive analysis of the PAP is presented, and the closed-form results established include: general statistics, stationary statistics, short-range and long-range dependencies, a Central Limit Theorem, an Extreme Limit Theorem, and fractality.

  20. Generalized linear longitudinal mixed models with linear covariance structure and multiplicative random effects

    DEFF Research Database (Denmark)

    Holst, René; Jørgensen, Bent

    2015-01-01

    The paper proposes a versatile class of multiplicative generalized linear longitudinal mixed models (GLLMM) with additive dispersion components, based on explicit modelling of the covariance structure. The class incorporates a longitudinal structure into the random effects models and retains...... a marginal as well as a conditional interpretation. The estimation procedure is based on a computationally efficient quasi-score method for the regression parameters combined with a REML-like bias-corrected Pearson estimating function for the dispersion and correlation parameters. This avoids...... the multidimensional integral of the conventional GLMM likelihood and allows an extension of the robust empirical sandwich estimator for use with both association and regression parameters. The method is applied to a set of otholit data, used for age determination of fish....

  1. Stochastic foundations of undulatory transport phenomena: generalized Poisson-Kac processes—part III extensions and applications to kinetic theory and transport

    Science.gov (United States)

    Giona, Massimiliano; Brasiello, Antonio; Crescitelli, Silvestro

    2017-08-01

    This third part extends the theory of Generalized Poisson-Kac (GPK) processes to nonlinear stochastic models and to a continuum of states. Nonlinearity is treated in two ways: (i) as a dependence of the parameters (intensity of the stochastic velocity, transition rates) of the stochastic perturbation on the state variable, similarly to the case of nonlinear Langevin equations, and (ii) as the dependence of the stochastic microdynamic equations of motion on the statistical description of the process itself (nonlinear Fokker-Planck-Kac models). Several numerical and physical examples illustrate the theory. Gathering nonlinearity and a continuum of states, GPK theory provides a stochastic derivation of the nonlinear Boltzmann equation, furnishing a positive answer to the Kac’s program in kinetic theory. The transition from stochastic microdynamics to transport theory within the framework of the GPK paradigm is also addressed.

  2. A Seemingly Unrelated Poisson Regression Model

    OpenAIRE

    King, Gary

    1989-01-01

    This article introduces a new estimator for the analysis of two contemporaneously correlated endogenous event count variables. This seemingly unrelated Poisson regression model (SUPREME) estimator combines the efficiencies created by single equation Poisson regression model estimators and insights from "seemingly unrelated" linear regression models.

  3. Multivariate statistical modelling based on generalized linear models

    CERN Document Server

    Fahrmeir, Ludwig

    1994-01-01

    This book is concerned with the use of generalized linear models for univariate and multivariate regression analysis. Its emphasis is to provide a detailed introductory survey of the subject based on the analysis of real data drawn from a variety of subjects including the biological sciences, economics, and the social sciences. Where possible, technical details and proofs are deferred to an appendix in order to provide an accessible account for non-experts. Topics covered include: models for multi-categorical responses, model checking, time series and longitudinal data, random effects models, and state-space models. Throughout, the authors have taken great pains to discuss the underlying theoretical ideas in ways that relate well to the data at hand. As a result, numerous researchers whose work relies on the use of these models will find this an invaluable account to have on their desks. "The basic aim of the authors is to bring together and review a large part of recent advances in statistical modelling of m...

  4. Generalized Functional Linear Models With Semiparametric Single-Index Interactions

    KAUST Repository

    Li, Yehua

    2010-06-01

    We introduce a new class of functional generalized linear models, where the response is a scalar and some of the covariates are functional. We assume that the response depends on multiple covariates, a finite number of latent features in the functional predictor, and interaction between the two. To achieve parsimony, the interaction between the multiple covariates and the functional predictor is modeled semiparametrically with a single-index structure. We propose a two step estimation procedure based on local estimating equations, and investigate two situations: (a) when the basis functions are pre-determined, e.g., Fourier or wavelet basis functions and the functional features of interest are known; and (b) when the basis functions are data driven, such as with functional principal components. Asymptotic properties are developed. Notably, we show that when the functional features are data driven, the parameter estimates have an increased asymptotic variance, due to the estimation error of the basis functions. Our methods are illustrated with a simulation study and applied to an empirical data set, where a previously unknown interaction is detected. Technical proofs of our theoretical results are provided in the online supplemental materials.

  5. Generalized linear isotherm regularity equation of state applied to metals

    Directory of Open Access Journals (Sweden)

    H. Sun

    2012-03-01

    Full Text Available A three-parameter equation of state (EOS without physically incorrect oscillations is proposed based on the generalized Lennard-Jones (GLJ potential and the approach in developing linear isotherm regularity (LIR EOS of Parsafar and Mason [J. Phys. Chem., 1994, 49, 3049]. The proposed (GLIR EOS can include the LIR EOS therein as a special case. The three-parameter GLIR, Parsafar and Mason (PM [Phys. Rev. B, 1994, 49, 3049], Shanker, Singh and Kushwah (SSK [Physica B, 1997, 229, 419], Parsafar, Spohr and Patey (PSP [J. Phys. Chem. B, 2009, 113, 11980], and reformulated PM and SSK EOSs are applied to 30 metallic solids within wide pressure ranges. It is shown that the PM, PMR and PSP EOSs for most solids, and the SSK and SSKR EOSs for several solids, have physically incorrect turning points, and pressure becomes negative at high enough pressure. The GLIR EOS is capable not only of overcoming the problem existing in other five EOSs where the pressure becomes negative at high pressure, but also gives results superior to other EOSs

  6. Detection of Fraudulent Transactions Through a Generalized Mixed Linear Models

    Directory of Open Access Journals (Sweden)

    Jackelyne Gómez–Restrepo

    2012-12-01

    Full Text Available The detection of bank frauds is a topic which many financial sector companieshave invested time and resources into. However, finding patterns inthe methodologies used to commit fraud in banks is a job that primarily involvesintimate knowledge of customer behavior, with the idea of isolatingthose transactions which do not correspond to what the client usually does.Thus, the solutions proposed in literature tend to focus on identifying outliersor groups, but fail to analyse each client or forecast fraud. This paperevaluates the implementation of a generalized linear model to detect fraud.With this model, unlike conventional methods, we consider the heterogeneityof customers. We not only generate a global model, but also a model for eachcustomer which describes the behavior of each one according to their transactionalhistory and previously detected fraudulent transactions. In particular,a mixed logistic model is used to estimate the probability that a transactionis fraudulent, using information that has been taken by the banking systemsin different moments of time.

  7. The linearized inversion of the generalized interferometric multiple imaging

    KAUST Repository

    Aldawood, Ali

    2016-09-06

    The generalized interferometric multiple imaging (GIMI) procedure can be used to image duplex waves and other higher order internal multiples. Imaging duplex waves could help illuminate subsurface zones that are not easily illuminated by primaries such as vertical and nearly vertical fault planes, and salt flanks. To image first-order internal multiple, the GIMI framework consists of three datuming steps, followed by applying the zero-lag cross-correlation imaging condition. However, the standard GIMI procedure yields migrated images that suffer from low spatial resolution, migration artifacts, and cross-talk noise. To alleviate these problems, we propose a least-squares GIMI framework in which we formulate the first two steps as a linearized inversion problem when imaging first-order internal multiples. Tests on synthetic datasets demonstrate the ability to localize subsurface scatterers in their true positions, and delineate a vertical fault plane using the proposed method. We, also, demonstrate the robustness of the proposed framework when imaging the scatterers or the vertical fault plane with erroneous migration velocities.

  8. Cavity characterization for general use in linear electron accelerators

    International Nuclear Information System (INIS)

    Souza Neto, M.V. de.

    1985-01-01

    The main objective of this work is to is to develop measurement techniques for the characterization of microwave cavities used in linear electron accelerators. Methods are developed for the measurement of parameters that are essential to the design of an accelerator structure using conventional techniques of resonant cavities at low power. Disk-loaded cavities were designed and built, similar to those in most existing linear electron accelerators. As a result, the methods developed and the estimated accuracy were compared with those from other investigators. The results of this work are relevant for the design of cavities with the objective of developing linear electron accelerators. (author) [pt

  9. Methodological quality and reporting of generalized linear mixed models in clinical medicine (2000-2012): a systematic review.

    Science.gov (United States)

    Casals, Martí; Girabent-Farrés, Montserrat; Carrasco, Josep L

    2014-01-01

    Modeling count and binary data collected in hierarchical designs have increased the use of Generalized Linear Mixed Models (GLMMs) in medicine. This article presents a systematic review of the application and quality of results and information reported from GLMMs in the field of clinical medicine. A search using the Web of Science database was performed for published original articles in medical journals from 2000 to 2012. The search strategy included the topic "generalized linear mixed models","hierarchical generalized linear models", "multilevel generalized linear model" and as a research domain we refined by science technology. Papers reporting methodological considerations without application, and those that were not involved in clinical medicine or written in English were excluded. A total of 443 articles were detected, with an increase over time in the number of articles. In total, 108 articles fit the inclusion criteria. Of these, 54.6% were declared to be longitudinal studies, whereas 58.3% and 26.9% were defined as repeated measurements and multilevel design, respectively. Twenty-two articles belonged to environmental and occupational public health, 10 articles to clinical neurology, 8 to oncology, and 7 to infectious diseases and pediatrics. The distribution of the response variable was reported in 88% of the articles, predominantly Binomial (n = 64) or Poisson (n = 22). Most of the useful information about GLMMs was not reported in most cases. Variance estimates of random effects were described in only 8 articles (9.2%). The model validation, the method of covariate selection and the method of goodness of fit were only reported in 8.0%, 36.8% and 14.9% of the articles, respectively. During recent years, the use of GLMMs in medical literature has increased to take into account the correlation of data when modeling qualitative data or counts. According to the current recommendations, the quality of reporting has room for improvement regarding the

  10. A general maximum likelihood analysis of variance components in generalized linear models.

    Science.gov (United States)

    Aitkin, M

    1999-03-01

    This paper describes an EM algorithm for nonparametric maximum likelihood (ML) estimation in generalized linear models with variance component structure. The algorithm provides an alternative analysis to approximate MQL and PQL analyses (McGilchrist and Aisbett, 1991, Biometrical Journal 33, 131-141; Breslow and Clayton, 1993; Journal of the American Statistical Association 88, 9-25; McGilchrist, 1994, Journal of the Royal Statistical Society, Series B 56, 61-69; Goldstein, 1995, Multilevel Statistical Models) and to GEE analyses (Liang and Zeger, 1986, Biometrika 73, 13-22). The algorithm, first given by Hinde and Wood (1987, in Longitudinal Data Analysis, 110-126), is a generalization of that for random effect models for overdispersion in generalized linear models, described in Aitkin (1996, Statistics and Computing 6, 251-262). The algorithm is initially derived as a form of Gaussian quadrature assuming a normal mixing distribution, but with only slight variation it can be used for a completely unknown mixing distribution, giving a straightforward method for the fully nonparametric ML estimation of this distribution. This is of value because the ML estimates of the GLM parameters can be sensitive to the specification of a parametric form for the mixing distribution. The nonparametric analysis can be extended straightforwardly to general random parameter models, with full NPML estimation of the joint distribution of the random parameters. This can produce substantial computational saving compared with full numerical integration over a specified parametric distribution for the random parameters. A simple method is described for obtaining correct standard errors for parameter estimates when using the EM algorithm. Several examples are discussed involving simple variance component and longitudinal models, and small-area estimation.

  11. General Linearized Theory of Quantum Fluctuations around Arbitrary Limit Cycles.

    Science.gov (United States)

    Navarrete-Benlloch, Carlos; Weiss, Talitha; Walter, Stefan; de Valcárcel, Germán J

    2017-09-29

    The theory of Gaussian quantum fluctuations around classical steady states in nonlinear quantum-optical systems (also known as standard linearization) is a cornerstone for the analysis of such systems. Its simplicity, together with its accuracy far from critical points or situations where the nonlinearity reaches the strong coupling regime, has turned it into a widespread technique, being the first method of choice in most works on the subject. However, such a technique finds strong practical and conceptual complications when one tries to apply it to situations in which the classical long-time solution is time dependent, a most prominent example being spontaneous limit-cycle formation. Here, we introduce a linearization scheme adapted to such situations, using the driven Van der Pol oscillator as a test bed for the method, which allows us to compare it with full numerical simulations. On a conceptual level, the scheme relies on the connection between the emergence of limit cycles and the spontaneous breaking of the symmetry under temporal translations. On the practical side, the method keeps the simplicity and linear scaling with the size of the problem (number of modes) characteristic of standard linearization, making it applicable to large (many-body) systems.

  12. A General Linear Method for Equating with Small Samples

    Science.gov (United States)

    Albano, Anthony D.

    2015-01-01

    Research on equating with small samples has shown that methods with stronger assumptions and fewer statistical estimates can lead to decreased error in the estimated equating function. This article introduces a new approach to linear observed-score equating, one which provides flexible control over how form difficulty is assumed versus estimated…

  13. Generalizing a Categorization of Students' Interpretations of Linear Kinematics Graphs

    Science.gov (United States)

    Bollen, Laurens; De Cock, Mieke; Zuza, Kristina; Guisasola, Jenaro; van Kampen, Paul

    2016-01-01

    We have investigated whether and how a categorization of responses to questions on linear distance-time graphs, based on a study of Irish students enrolled in an algebra-based course, could be adopted and adapted to responses from students enrolled in calculus-based physics courses at universities in Flanders, Belgium (KU Leuven) and the Basque…

  14. Linearly convergent stochastic heavy ball method for minimizing generalization error

    KAUST Repository

    Loizou, Nicolas

    2017-10-30

    In this work we establish the first linear convergence result for the stochastic heavy ball method. The method performs SGD steps with a fixed stepsize, amended by a heavy ball momentum term. In the analysis, we focus on minimizing the expected loss and not on finite-sum minimization, which is typically a much harder problem. While in the analysis we constrain ourselves to quadratic loss, the overall objective is not necessarily strongly convex.

  15. Generalizing a categorization of students’ interpretations of linear kinematics graphs

    Directory of Open Access Journals (Sweden)

    Laurens Bollen

    2016-02-01

    Full Text Available We have investigated whether and how a categorization of responses to questions on linear distance-time graphs, based on a study of Irish students enrolled in an algebra-based course, could be adopted and adapted to responses from students enrolled in calculus-based physics courses at universities in Flanders, Belgium (KU Leuven and the Basque Country, Spain (University of the Basque Country. We discuss how we adapted the categorization to accommodate a much more diverse student cohort and explain how the prior knowledge of students may account for many differences in the prevalence of approaches and success rates. Although calculus-based physics students make fewer mistakes than algebra-based physics students, they encounter similar difficulties that are often related to incorrectly dividing two coordinates. We verified that a qualitative understanding of kinematics is an important but not sufficient condition for students to determine a correct value for the speed. When comparing responses to questions on linear distance-time graphs with responses to isomorphic questions on linear water level versus time graphs, we observed that the context of a question influences the approach students use. Neither qualitative understanding nor an ability to find the slope of a context-free graph proved to be a reliable predictor for the approach students use when they determine the instantaneous speed.

  16. Maximum Likelihood in a Generalized Linear Finite Mixture Model by Using the EM Algorithm

    NARCIS (Netherlands)

    Jansen, R.C.

    A generalized linear finite mixture model and an EM algorithm to fit the model to data are described. By this approach the finite mixture model is embedded within the general framework of generalized linear models (GLMs). Implementation of the proposed EM algorithm can be readily done in statistical

  17. Mapping the annual exceedance frequencies of the PM10 air quality standard - Comparing kriging to a generalized linear spatial model

    CSIR Research Space (South Africa)

    Khuluse, S

    2013-11-01

    Full Text Available compare ordinary and regression kriging models to the Poisson log-linear spatial model (Diggle et al. 1998, Diggle et al. 2007) with and without covariate information in mapping annual average exceedance frequencies of the South African PM10 air quality...

  18. Application of generalized linear models to estimate height growth

    OpenAIRE

    Hess, Andre Felipe; Cianorschi, Lucas; Silvestre, Raul; Scariot, Rafael; Ricken, Pollyni

    2015-01-01

    A análise do crescimento em altura é de extrema importância na área florestal, pois expressa a capacidade produtiva do local. Seu uso está associado ao ajuste, com menor erro, dos modelos para gerar estimativas que permitam a inferência com precisão e confiabilidade. O presente trabalho analisou o emprego dos modelos lineares generalizados na predição do crescimento em altura de Pinus taeda L. em função da idade e diâmetro a 1,30 m de altura em povoamentos no planalto catarinense. Os dados ut...

  19. Homogeneous Poisson structures

    International Nuclear Information System (INIS)

    Shafei Deh Abad, A.; Malek, F.

    1993-09-01

    We provide an algebraic definition for Schouten product and give a decomposition for any homogenenous Poisson structure in any n-dimensional vector space. A large class of n-homogeneous Poisson structures in R k is also characterized. (author). 4 refs

  20. Weight Smoothing for Generalized Linear Models Using a Laplace Prior

    Science.gov (United States)

    Xia, Xi; Elliott, Michael R.

    2017-01-01

    When analyzing data sampled with unequal inclusion probabilities, correlations between the probability of selection and the sampled data can induce bias if the inclusion probabilities are ignored in the analysis. Weights equal to the inverse of the probability of inclusion are commonly used to correct possible bias. When weights are uncorrelated with the descriptive or model estimators of interest, highly disproportional sample designs resulting in large weights can introduce unnecessary variability, leading to an overall larger mean square error compared to unweighted methods. We describe an approach we term ‘weight smoothing’ that models the interactions between the weights and the estimators as random effects, reducing the root mean square error (RMSE) by shrinking interactions toward zero when such shrinkage is allowed by the data. This article adapts a flexible Laplace prior distribution for the hierarchical Bayesian model to gain a more robust bias-variance tradeoff than previous approaches using normal priors. Simulation and application suggest that under a linear model setting, weight-smoothing models with Laplace priors yield robust results when weighting is necessary, and provide considerable reduction in RMSE otherwise. In logistic regression models, estimates using weight-smoothing models with Laplace priors are robust, but with less gain in efficiency than in linear regression settings. PMID:29225401

  1. Evidence synthesis for decision making 2: a generalized linear modeling framework for pairwise and network meta-analysis of randomized controlled trials.

    Science.gov (United States)

    Dias, Sofia; Sutton, Alex J; Ades, A E; Welton, Nicky J

    2013-07-01

    We set out a generalized linear model framework for the synthesis of data from randomized controlled trials. A common model is described, taking the form of a linear regression for both fixed and random effects synthesis, which can be implemented with normal, binomial, Poisson, and multinomial data. The familiar logistic model for meta-analysis with binomial data is a generalized linear model with a logit link function, which is appropriate for probability outcomes. The same linear regression framework can be applied to continuous outcomes, rate models, competing risks, or ordered category outcomes by using other link functions, such as identity, log, complementary log-log, and probit link functions. The common core model for the linear predictor can be applied to pairwise meta-analysis, indirect comparisons, synthesis of multiarm trials, and mixed treatment comparisons, also known as network meta-analysis, without distinction. We take a Bayesian approach to estimation and provide WinBUGS program code for a Bayesian analysis using Markov chain Monte Carlo simulation. An advantage of this approach is that it is straightforward to extend to shared parameter models where different randomized controlled trials report outcomes in different formats but from a common underlying model. Use of the generalized linear model framework allows us to present a unified account of how models can be compared using the deviance information criterion and how goodness of fit can be assessed using the residual deviance. The approach is illustrated through a range of worked examples for commonly encountered evidence formats.

  2. A general algorithm for computing distance transforms in linear time

    NARCIS (Netherlands)

    Meijster, A.; Roerdink, J.B.T.M.; Hesselink, W.H.; Goutsias, J; Vincent, L; Bloomberg, DS

    2000-01-01

    A new general algorithm fur computing distance transforms of digital images is presented. The algorithm consists of two phases. Both phases consist of two scans, a forward and a backward scan. The first phase scans the image column-wise, while the second phase scans the image row-wise. Since the

  3. Generalized Heisenberg algebra and (non linear) pseudo-bosons

    Science.gov (United States)

    Bagarello, F.; Curado, E. M. F.; Gazeau, J. P.

    2018-04-01

    We propose a deformed version of the generalized Heisenberg algebra by using techniques borrowed from the theory of pseudo-bosons. In particular, this analysis is relevant when non self-adjoint Hamiltonians are needed to describe a given physical system. We also discuss relations with nonlinear pseudo-bosons. Several examples are discussed.

  4. Commensurate Priors for Incorporating Historical Information in Clinical Trials Using General and Generalized Linear Models

    Science.gov (United States)

    Hobbs, Brian P.; Sargent, Daniel J.; Carlin, Bradley P.

    2014-01-01

    Assessing between-study variability in the context of conventional random-effects meta-analysis is notoriously difficult when incorporating data from only a small number of historical studies. In order to borrow strength, historical and current data are often assumed to be fully homogeneous, but this can have drastic consequences for power and Type I error if the historical information is biased. In this paper, we propose empirical and fully Bayesian modifications of the commensurate prior model (Hobbs et al., 2011) extending Pocock (1976), and evaluate their frequentist and Bayesian properties for incorporating patient-level historical data using general and generalized linear mixed regression models. Our proposed commensurate prior models lead to preposterior admissible estimators that facilitate alternative bias-variance trade-offs than those offered by pre-existing methodologies for incorporating historical data from a small number of historical studies. We also provide a sample analysis of a colon cancer trial comparing time-to-disease progression using a Weibull regression model. PMID:24795786

  5. Zeroth Poisson Homology, Foliated Cohomology and Perfect Poisson Manifolds

    Science.gov (United States)

    Martínez-Torres, David; Miranda, Eva

    2018-01-01

    We prove that, for compact regular Poisson manifolds, the zeroth homology group is isomorphic to the top foliated cohomology group, and we give some applications. In particular, we show that, for regular unimodular Poisson manifolds, top Poisson and foliated cohomology groups are isomorphic. Inspired by the symplectic setting, we define what a perfect Poisson manifold is. We use these Poisson homology computations to provide families of perfect Poisson manifolds.

  6. Modifications to POISSON

    International Nuclear Information System (INIS)

    Harwood, L.H.

    1981-01-01

    At MSU we have used the POISSON family of programs extensively for magnetic field calculations. In the presently super-saturated computer situation, reducing the run time for the program is imperative. Thus, a series of modifications have been made to POISSON to speed up convergence. Two of the modifications aim at having the first guess solution as close as possible to the final solution. The other two aim at increasing the convergence rate. In this discussion, a working knowledge of POISSON is assumed. The amount of new code and expected time saving for each modification is discussed

  7. Item Purification in Differential Item Functioning Using Generalized Linear Mixed Models

    Science.gov (United States)

    Liu, Qian

    2011-01-01

    For this dissertation, four item purification procedures were implemented onto the generalized linear mixed model for differential item functioning (DIF) analysis, and the performance of these item purification procedures was investigated through a series of simulations. Among the four procedures, forward and generalized linear mixed model (GLMM)…

  8. The Morava E-theories of finite general linear groups

    Science.gov (United States)

    Mattafirri, Sara

    block detector few centimeters in size is used. The resolution significantly improves with increasing energy of the photons and it degrades roughly linearly with increasing distance from the detector; Larger detection efficiency can be obtained at the expenses of resolution or via targeted configurations of the detector. Results pave the way for image reconstruction of practical gamma-ray emitting sources.

  9. Scaling the Poisson Distribution

    Science.gov (United States)

    Farnsworth, David L.

    2014-01-01

    We derive the additive property of Poisson random variables directly from the probability mass function. An important application of the additive property to quality testing of computer chips is presented.

  10. On Poisson Nonlinear Transformations

    Directory of Open Access Journals (Sweden)

    Nasir Ganikhodjaev

    2014-01-01

    Full Text Available We construct the family of Poisson nonlinear transformations defined on the countable sample space of nonnegative integers and investigate their trajectory behavior. We have proved that these nonlinear transformations are regular.

  11. Extended Poisson Exponential Distribution

    Directory of Open Access Journals (Sweden)

    Anum Fatima

    2015-09-01

    Full Text Available A new mixture of Modified Exponential (ME and Poisson distribution has been introduced in this paper. Taking the Maximum of Modified Exponential random variable when the sample size follows a zero truncated Poisson distribution we have derived the new distribution, named as Extended Poisson Exponential distribution. This distribution possesses increasing and decreasing failure rates. The Poisson-Exponential, Modified Exponential and Exponential distributions are special cases of this distribution. We have also investigated some mathematical properties of the distribution along with Information entropies and Order statistics of the distribution. The estimation of parameters has been obtained using the Maximum Likelihood Estimation procedure. Finally we have illustrated a real data application of our distribution.

  12. Reduction of Nambu-Poisson Manifolds by Regular Distributions

    Science.gov (United States)

    Das, Apurba

    2018-03-01

    The version of Marsden-Ratiu reduction theorem for Nambu-Poisson manifolds by a regular distribution has been studied by Ibáñez et al. In this paper we show that the reduction is always ensured unless the distribution is zero. Next we extend the more general Falceto-Zambon Poisson reduction theorem for Nambu-Poisson manifolds. Finally, we define gauge transformations of Nambu-Poisson structures and show that these transformations commute with the reduction procedure.

  13. Examining secular trend  and seasonality in count data using dynamic generalized linear modelling

    DEFF Research Database (Denmark)

    Lundbye-Christensen, Søren; Dethlefsen, Claus; Gorst-Rasmussen, Anders

    Aims  Time series of incidence counts often show secular trends and seasonal patterns. We present a model for incidence counts capable of handling a possible gradual change in growth rates and seasonal patterns, serial correlation and overdispersion. Methods  The model resembles an ordinary time...... series regression model for Poisson counts. It differs in allowing the regression coefficients to vary gradually over time in a random fashion. Data  In the period January 1980 to 1999, 17,989 incidents of acute myocardial infarction were recorded in the county of Northern Jutland, Denmark. Records were...... updated daily. Results  The model with a seasonal pattern and an approximately linear trend was fitted to the data, and diagnostic plots indicate a good model fit. The analysis with the dynamic model revealed peaks coinciding with influenza epidemics. On average the peak-to-trough ratio is estimated...

  14. Methodological quality and reporting of generalized linear mixed models in clinical medicine (2000-2012: a systematic review.

    Directory of Open Access Journals (Sweden)

    Martí Casals

    Full Text Available BACKGROUND: Modeling count and binary data collected in hierarchical designs have increased the use of Generalized Linear Mixed Models (GLMMs in medicine. This article presents a systematic review of the application and quality of results and information reported from GLMMs in the field of clinical medicine. METHODS: A search using the Web of Science database was performed for published original articles in medical journals from 2000 to 2012. The search strategy included the topic "generalized linear mixed models","hierarchical generalized linear models", "multilevel generalized linear model" and as a research domain we refined by science technology. Papers reporting methodological considerations without application, and those that were not involved in clinical medicine or written in English were excluded. RESULTS: A total of 443 articles were detected, with an increase over time in the number of articles. In total, 108 articles fit the inclusion criteria. Of these, 54.6% were declared to be longitudinal studies, whereas 58.3% and 26.9% were defined as repeated measurements and multilevel design, respectively. Twenty-two articles belonged to environmental and occupational public health, 10 articles to clinical neurology, 8 to oncology, and 7 to infectious diseases and pediatrics. The distribution of the response variable was reported in 88% of the articles, predominantly Binomial (n = 64 or Poisson (n = 22. Most of the useful information about GLMMs was not reported in most cases. Variance estimates of random effects were described in only 8 articles (9.2%. The model validation, the method of covariate selection and the method of goodness of fit were only reported in 8.0%, 36.8% and 14.9% of the articles, respectively. CONCLUSIONS: During recent years, the use of GLMMs in medical literature has increased to take into account the correlation of data when modeling qualitative data or counts. According to the current recommendations, the

  15. Development of planning level transportation safety tools using Geographically Weighted Poisson Regression.

    Science.gov (United States)

    Hadayeghi, Alireza; Shalaby, Amer S; Persaud, Bhagwant N

    2010-03-01

    A common technique used for the calibration of collision prediction models is the Generalized Linear Modeling (GLM) procedure with the assumption of Negative Binomial or Poisson error distribution. In this technique, fixed coefficients that represent the average relationship between the dependent variable and each explanatory variable are estimated. However, the stationary relationship assumed may hide some important spatial factors of the number of collisions at a particular traffic analysis zone. Consequently, the accuracy of such models for explaining the relationship between the dependent variable and the explanatory variables may be suspected since collision frequency is likely influenced by many spatially defined factors such as land use, demographic characteristics, and traffic volume patterns. The primary objective of this study is to investigate the spatial variations in the relationship between the number of zonal collisions and potential transportation planning predictors, using the Geographically Weighted Poisson Regression modeling technique. The secondary objective is to build on knowledge comparing the accuracy of Geographically Weighted Poisson Regression models to that of Generalized Linear Models. The results show that the Geographically Weighted Poisson Regression models are useful for capturing spatially dependent relationships and generally perform better than the conventional Generalized Linear Models. Copyright 2009 Elsevier Ltd. All rights reserved.

  16. Simple, efficient estimators of treatment effects in randomized trials using generalized linear models to leverage baseline variables.

    Science.gov (United States)

    Rosenblum, Michael; van der Laan, Mark J

    2010-04-01

    Models, such as logistic regression and Poisson regression models, are often used to estimate treatment effects in randomized trials. These models leverage information in variables collected before randomization, in order to obtain more precise estimates of treatment effects. However, there is the danger that model misspecification will lead to bias. We show that certain easy to compute, model-based estimators are asymptotically unbiased even when the working model used is arbitrarily misspecified. Furthermore, these estimators are locally efficient. As a special case of our main result, we consider a simple Poisson working model containing only main terms; in this case, we prove the maximum likelihood estimate of the coefficient corresponding to the treatment variable is an asymptotically unbiased estimator of the marginal log rate ratio, even when the working model is arbitrarily misspecified. This is the log-linear analog of ANCOVA for linear models. Our results demonstrate one application of targeted maximum likelihood estimation.

  17. Poisson structure of dynamical systems with three degrees of freedom

    Science.gov (United States)

    Gümral, Hasan; Nutku, Yavuz

    1993-12-01

    It is shown that the Poisson structure of dynamical systems with three degrees of freedom can be defined in terms of an integrable one-form in three dimensions. Advantage is taken of this fact and the theory of foliations is used in discussing the geometrical structure underlying complete and partial integrability. Techniques for finding Poisson structures are presented and applied to various examples such as the Halphen system which has been studied as the two-monopole problem by Atiyah and Hitchin. It is shown that the Halphen system can be formulated in terms of a flat SL(2,R)-valued connection and belongs to a nontrivial Godbillon-Vey class. On the other hand, for the Euler top and a special case of three-species Lotka-Volterra equations which are contained in the Halphen system as limiting cases, this structure degenerates into the form of globally integrable bi-Hamiltonian structures. The globally integrable bi-Hamiltonian case is a linear and the SL(2,R) structure is a quadratic unfolding of an integrable one-form in 3+1 dimensions. It is shown that the existence of a vector field compatible with the flow is a powerful tool in the investigation of Poisson structure and some new techniques for incorporating arbitrary constants into the Poisson one-form are presented herein. This leads to some extensions, analogous to q extensions, of Poisson structure. The Kermack-McKendrick model and some of its generalizations describing the spread of epidemics, as well as the integrable cases of the Lorenz, Lotka-Volterra, May-Leonard, and Maxwell-Bloch systems admit globally integrable bi-Hamiltonian structure.

  18. Sensitivity theory for general non-linear algebraic equations with constraints

    International Nuclear Information System (INIS)

    Oblow, E.M.

    1977-04-01

    Sensitivity theory has been developed to a high state of sophistication for applications involving solutions of the linear Boltzmann equation or approximations to it. The success of this theory in the field of radiation transport has prompted study of possible extensions of the method to more general systems of non-linear equations. Initial work in the U.S. and in Europe on the reactor fuel cycle shows that the sensitivity methodology works equally well for those non-linear problems studied to date. The general non-linear theory for algebraic equations is summarized and applied to a class of problems whose solutions are characterized by constrained extrema. Such equations form the basis of much work on energy systems modelling and the econometrics of power production and distribution. It is valuable to have a sensitivity theory available for these problem areas since it is difficult to repeatedly solve complex non-linear equations to find out the effects of alternative input assumptions or the uncertainties associated with predictions of system behavior. The sensitivity theory for a linear system of algebraic equations with constraints which can be solved using linear programming techniques is discussed. The role of the constraints in simplifying the problem so that sensitivity methodology can be applied is highlighted. The general non-linear method is summarized and applied to a non-linear programming problem in particular. Conclusions are drawn in about the applicability of the method for practical problems

  19. The Generalized Logit-Linear Item Response Model for Binary-Designed Items

    Science.gov (United States)

    Revuelta, Javier

    2008-01-01

    This paper introduces the generalized logit-linear item response model (GLLIRM), which represents the item-solving process as a series of dichotomous operations or steps. The GLLIRM assumes that the probability function of the item response is a logistic function of a linear composite of basic parameters which describe the operations, and the…

  20. Doubly robust estimation of generalized partial linear models for longitudinal data with dropouts.

    Science.gov (United States)

    Lin, Huiming; Fu, Bo; Qin, Guoyou; Zhu, Zhongyi

    2017-12-01

    We develop a doubly robust estimation of generalized partial linear models for longitudinal data with dropouts. Our method extends the highly efficient aggregate unbiased estimating function approach proposed in Qu et al. (2010) to a doubly robust one in the sense that under missing at random (MAR), our estimator is consistent when either the linear conditional mean condition is satisfied or a model for the dropout process is correctly specified. We begin with a generalized linear model for the marginal mean, and then move forward to a generalized partial linear model, allowing for nonparametric covariate effect by using the regression spline smoothing approximation. We establish the asymptotic theory for the proposed method and use simulation studies to compare its finite sample performance with that of Qu's method, the complete-case generalized estimating equation (GEE) and the inverse-probability weighted GEE. The proposed method is finally illustrated using data from a longitudinal cohort study. © 2017, The International Biometric Society.

  1. Principal components and generalized linear modeling in the correlation between hospital admissions and air pollution

    Science.gov (United States)

    de Souza, Juliana Bottoni; Reisen, Valdério Anselmo; Santos, Jane Méri; Franco, Glaura Conceição

    2014-01-01

    OBJECTIVE To analyze the association between concentrations of air pollutants and admissions for respiratory causes in children. METHODS Ecological time series study. Daily figures for hospital admissions of children aged < 6, and daily concentrations of air pollutants (PM10, SO2, NO2, O3 and CO) were analyzed in the Região da Grande Vitória, ES, Southeastern Brazil, from January 2005 to December 2010. For statistical analysis, two techniques were combined: Poisson regression with generalized additive models and principal model component analysis. Those analysis techniques complemented each other and provided more significant estimates in the estimation of relative risk. The models were adjusted for temporal trend, seasonality, day of the week, meteorological factors and autocorrelation. In the final adjustment of the model, it was necessary to include models of the Autoregressive Moving Average Models (p, q) type in the residuals in order to eliminate the autocorrelation structures present in the components. RESULTS For every 10:49 μg/m3 increase (interquartile range) in levels of the pollutant PM10 there was a 3.0% increase in the relative risk estimated using the generalized additive model analysis of main components-seasonal autoregressive – while in the usual generalized additive model, the estimate was 2.0%. CONCLUSIONS Compared to the usual generalized additive model, in general, the proposed aspect of generalized additive model − principal component analysis, showed better results in estimating relative risk and quality of fit. PMID:25119940

  2. Generalized linear mixed models can detect unimodal species-environment relationships.

    Science.gov (United States)

    Jamil, Tahira; Ter Braak, Cajo J F

    2013-01-01

    Niche theory predicts that species occurrence and abundance show non-linear, unimodal relationships with respect to environmental gradients. Unimodal models, such as the Gaussian (logistic) model, are however more difficult to fit to data than linear ones, particularly in a multi-species context in ordination, with trait modulated response and when species phylogeny and species traits must be taken into account. Adding squared terms to a linear model is a possibility but gives uninterpretable parameters. This paper explains why and when generalized linear mixed models, even without squared terms, can effectively analyse unimodal data and also presents a graphical tool and statistical test to test for unimodal response while fitting just the generalized linear mixed model. The R-code for this is supplied in Supplemental Information 1.

  3. Estimation of group means when adjusting for covariates in generalized linear models.

    Science.gov (United States)

    Qu, Yongming; Luo, Junxiang

    2015-01-01

    Generalized linear models are commonly used to analyze categorical data such as binary, count, and ordinal outcomes. Adjusting for important prognostic factors or baseline covariates in generalized linear models may improve the estimation efficiency. The model-based mean for a treatment group produced by most software packages estimates the response at the mean covariate, not the mean response for this treatment group for the studied population. Although this is not an issue for linear models, the model-based group mean estimates in generalized linear models could be seriously biased for the true group means. We propose a new method to estimate the group mean consistently with the corresponding variance estimation. Simulation showed the proposed method produces an unbiased estimator for the group means and provided the correct coverage probability. The proposed method was applied to analyze hypoglycemia data from clinical trials in diabetes. Copyright © 2014 John Wiley & Sons, Ltd.

  4. Paretian Poisson Processes

    Science.gov (United States)

    Eliazar, Iddo; Klafter, Joseph

    2008-05-01

    Many random populations can be modeled as a countable set of points scattered randomly on the positive half-line. The points may represent magnitudes of earthquakes and tornados, masses of stars, market values of public companies, etc. In this article we explore a specific class of random such populations we coin ` Paretian Poisson processes'. This class is elemental in statistical physics—connecting together, in a deep and fundamental way, diverse issues including: the Poisson distribution of the Law of Small Numbers; Paretian tail statistics; the Fréchet distribution of Extreme Value Theory; the one-sided Lévy distribution of the Central Limit Theorem; scale-invariance, renormalization and fractality; resilience to random perturbations.

  5. Stationary response of multi-degree-of-freedom vibro-impact systems to Poisson white noises

    International Nuclear Information System (INIS)

    Wu, Y.; Zhu, W.Q.

    2008-01-01

    The stationary response of multi-degree-of-freedom (MDOF) vibro-impact (VI) systems to random pulse trains is studied. The system is formulated as a stochastically excited and dissipated Hamiltonian system. The constraints are modeled as non-linear springs according to the Hertz contact law. The random pulse trains are modeled as Poisson white noises. The approximate stationary probability density function (PDF) for the response of MDOF dissipated Hamiltonian systems to Poisson white noises is obtained by solving the fourth-order generalized Fokker-Planck-Kolmogorov (FPK) equation using perturbation approach. As examples, two-degree-of-freedom (2DOF) VI systems under external and parametric Poisson white noise excitations, respectively, are investigated. The validity of the proposed approach is confirmed by using the results obtained from Monte Carlo simulation. It is shown that the non-Gaussian behaviour depends on the product of the mean arrival rate of the impulses and the relaxation time of the oscillator

  6. An efficient method for generalized linear multiplicative programming problem with multiplicative constraints.

    Science.gov (United States)

    Zhao, Yingfeng; Liu, Sanyang

    2016-01-01

    We present a practical branch and bound algorithm for globally solving generalized linear multiplicative programming problem with multiplicative constraints. To solve the problem, a relaxation programming problem which is equivalent to a linear programming is proposed by utilizing a new two-phase relaxation technique. In the algorithm, lower and upper bounds are simultaneously obtained by solving some linear relaxation programming problems. Global convergence has been proved and results of some sample examples and a small random experiment show that the proposed algorithm is feasible and efficient.

  7. Flexible Approaches to Computing Mediated Effects in Generalized Linear Models: Generalized Estimating Equations and Bootstrapping

    Science.gov (United States)

    Schluchter, Mark D.

    2008-01-01

    In behavioral research, interest is often in examining the degree to which the effect of an independent variable X on an outcome Y is mediated by an intermediary or mediator variable M. This article illustrates how generalized estimating equations (GEE) modeling can be used to estimate the indirect or mediated effect, defined as the amount by…

  8. Dualizing the Poisson summation formula.

    Science.gov (United States)

    Duffin, R J; Weinberger, H F

    1991-01-01

    If f(x) and g(x) are a Fourier cosine transform pair, then the Poisson summation formula can be written as 2sumfrominfinityn = 1g(n) + g(0) = 2sumfrominfinityn = 1f(n) + f(0). The concepts of linear transformation theory lead to the following dual of this classical relation. Let phi(x) and gamma(x) = phi(1/x)/x have absolutely convergent integrals over the positive real line. Let F(x) = sumfrominfinityn = 1phi(n/x)/x - integralinfinity0phi(t)dt and G(x) = sumfrominfinityn = 1gamma (n/x)/x - integralinfinity0 gamma(t)dt. Then F(x) and G(x) are a Fourier cosine transform pair. We term F(x) the "discrepancy" of phi because it is the error in estimating the integral phi of by its Riemann sum with the constant mesh spacing 1/x. PMID:11607208

  9. Consistent linearization of the element-independent corotational formulation for the structural analysis of general shells

    Science.gov (United States)

    Rankin, C. C.

    1988-01-01

    A consistent linearization is provided for the element-dependent corotational formulation, providing the proper first and second variation of the strain energy. As a result, the warping problem that has plagued flat elements has been overcome, with beneficial effects carried over to linear solutions. True Newton quadratic convergence has been restored to the Structural Analysis of General Shells (STAGS) code for conservative loading using the full corotational implementation. Some implications for general finite element analysis are discussed, including what effect the automatic frame invariance provided by this work might have on the development of new, improved elements.

  10. Generalized linear elastic fracture mechanics: an application to a crack touching the bimaterial interface

    Czech Academy of Sciences Publication Activity Database

    Náhlík, Luboš; Šestáková, L.; Hutař, Pavel; Knésl, Zdeněk

    2011-01-01

    Roč. 452-453, - (2011), s. 445-448 ISSN 1013-9826 R&D Projects: GA AV ČR(CZ) KJB200410803; GA ČR GA101/09/1821 Institutional research plan: CEZ:AV0Z20410507 Keywords : generalized stress intensity factor * bimaterial interface * composite materials * strain energy density factor * fracture criterion * generalized linear elastic fracture mechanics Subject RIV: JL - Materials Fatigue, Friction Mechanics

  11. General linear methods and friends: Toward efficient solutions of multiphysics problems

    Science.gov (United States)

    Sandu, Adrian

    2017-07-01

    Time dependent multiphysics partial differential equations are of great practical importance as they model diverse phenomena that appear in mechanical and chemical engineering, aeronautics, astrophysics, meteorology and oceanography, financial modeling, environmental sciences, etc. There is no single best time discretization for the complex multiphysics systems of practical interest. We discuss "multimethod" approaches that combine different time steps and discretizations using the rigourous frameworks provided by Partitioned General Linear Methods and Generalize-structure Additive Runge Kutta Methods..

  12. GLIMMIX : Software for estimating mixtures and mixtures of generalized linear models

    NARCIS (Netherlands)

    Wedel, M

    2001-01-01

    GLIMMIX is a commercial WINDOWS-based computer program that implements the EM algorithm (Dempster, Laird and Rubin 1977) for the estimation of finite mixtures and mixtures of generalized linear models. The program allows for the specification of a number of distributions in the exponential family,

  13. The microcomputer scientific software series 2: general linear model--regression.

    Science.gov (United States)

    Harold M. Rauscher

    1983-01-01

    The general linear model regression (GLMR) program provides the microcomputer user with a sophisticated regression analysis capability. The output provides a regression ANOVA table, estimators of the regression model coefficients, their confidence intervals, confidence intervals around the predicted Y-values, residuals for plotting, a check for multicollinearity, a...

  14. Generalized Partially Linear Regression with Misclassified Data and an Application to Labour Market Transitions

    DEFF Research Database (Denmark)

    Dlugosz, Stephan; Mammen, Enno; Wilke, Ralf

    2017-01-01

    observations from Germany. It is shown that estimated marginal effects of a number of covariates are sizeably affected by misclassification and missing values in the analysis data. The proposed generalized partially linear regression extends existing models by allowing a misclassified discrete covariate...

  15. On the distribution of discounted loss reserves using generalized linear models

    NARCIS (Netherlands)

    Hoedemakers, T.; Beirlant, J.; Goovaerts, M.J.; Dhaene, J.

    2005-01-01

    Renshaw and Verrall [11] specified the generalized linear model (GLM) underlying the chain-ladder technique and suggested some other GLMs which might be useful in claims reserving. The purpose of this paper is to construct bounds for the discounted loss reserve within the framework of GLMs. Exact

  16. Regression Is a Univariate General Linear Model Subsuming Other Parametric Methods as Special Cases.

    Science.gov (United States)

    Vidal, Sherry

    Although the concept of the general linear model (GLM) has existed since the 1960s, other univariate analyses such as the t-test and the analysis of variance models have remained popular. The GLM produces an equation that minimizes the mean differences of independent variables as they are related to a dependent variable. From a computer printout…

  17. A generalized variational algebra and conserved densities for linear evolution equations

    International Nuclear Information System (INIS)

    Abellanas, L.; Galindo, A.

    1978-01-01

    The symbolic algebra of Gel'fand and Dikii is generalized to the case of n variables. Using this algebraic approach a rigorous characterization of the polynomial kernel of the variational derivative is given. This is applied to classify all the conservation laws for linear polynomial evolution equations of arbitrary order. (Auth.)

  18. Bayesian prediction of spatial count data using generalized linear mixed models

    DEFF Research Database (Denmark)

    Christensen, Ole Fredslund; Waagepetersen, Rasmus Plenge

    2002-01-01

    Spatial weed count data are modeled and predicted using a generalized linear mixed model combined with a Bayesian approach and Markov chain Monte Carlo. Informative priors for a data set with sparse sampling are elicited using a previously collected data set with extensive sampling. Furthermore, ...

  19. More on Generalizations and Modifications of Iterative Methods for Solving Large Sparse Indefinite Linear Systems

    Directory of Open Access Journals (Sweden)

    Jen-Yuan Chen

    2014-01-01

    Full Text Available Continuing from the works of Li et al. (2014, Li (2007, and Kincaid et al. (2000, we present more generalizations and modifications of iterative methods for solving large sparse symmetric and nonsymmetric indefinite systems of linear equations. We discuss a variety of iterative methods such as GMRES, MGMRES, MINRES, LQ-MINRES, QR MINRES, MMINRES, MGRES, and others.

  20. On Extended Exponential General Linear Methods PSQ with S>Q ...

    African Journals Online (AJOL)

    This paper is concerned with the construction and Numerical Analysis of Extended Exponential General Linear Methods. These methods, in contrast to other methods in literatures, consider methods with the step greater than the stage order (S>Q).Numerical experiments in this study, indicate that Extended Exponential ...

  1. The Use of Hierarchical Generalized Linear Model for Item Dimensionality Assessment

    Science.gov (United States)

    Beretvas, S. Natasha; Williams, Natasha J.

    2004-01-01

    To assess item dimensionality, the following two approaches are described and compared: hierarchical generalized linear model (HGLM) and multidimensional item response theory (MIRT) model. Two generating models are used to simulate dichotomous responses to a 17-item test: the unidimensional and compensatory two-dimensional (C2D) models. For C2D…

  2. Modeling containment of large wildfires using generalized linear mixed-model analysis

    Science.gov (United States)

    Mark Finney; Isaac C. Grenfell; Charles W. McHugh

    2009-01-01

    Billions of dollars are spent annually in the United States to contain large wildland fires, but the factors contributing to suppression success remain poorly understood. We used a regression model (generalized linear mixed-model) to model containment probability of individual fires, assuming that containment was a repeated-measures problem (fixed effect) and...

  3. Structural Modeling of Measurement Error in Generalized Linear Models with Rasch Measures as Covariates

    Science.gov (United States)

    Battauz, Michela; Bellio, Ruggero

    2011-01-01

    This paper proposes a structural analysis for generalized linear models when some explanatory variables are measured with error and the measurement error variance is a function of the true variables. The focus is on latent variables investigated on the basis of questionnaires and estimated using item response theory models. Latent variable…

  4. A generalized linear factor model approach to the hierarchical framework for responses and response times

    NARCIS (Netherlands)

    Molenaar, D.; Tuerlinckx, F.; van der Maas, H.L.J.

    2015-01-01

    We show how the hierarchical model for responses and response times as developed by van der Linden (2007), Fox, Klein Entink, and van der Linden (2007), Klein Entink, Fox, and van der Linden (2009), and Glas and van der Linden (2010) can be simplified to a generalized linear factor model with only

  5. Mean-field approximations for coupled populations of generalized linear model spiking neurons with Markov refractoriness.

    Science.gov (United States)

    Toyoizumi, Taro; Rad, Kamiar Rahnama; Paninski, Liam

    2009-05-01

    There has recently been a great deal of interest in inferring network connectivity from the spike trains in populations of neurons. One class of useful models that can be fit easily to spiking data is based on generalized linear point process models from statistics. Once the parameters for these models are fit, the analyst is left with a nonlinear spiking network model with delays, which in general may be very difficult to understand analytically. Here we develop mean-field methods for approximating the stimulus-driven firing rates (in both the time-varying and steady-state cases), auto- and cross-correlations, and stimulus-dependent filtering properties of these networks. These approximations are valid when the contributions of individual network coupling terms are small and, hence, the total input to a neuron is approximately gaussian. These approximations lead to deterministic ordinary differential equations that are much easier to solve and analyze than direct Monte Carlo simulation of the network activity. These approximations also provide an analytical way to evaluate the linear input-output filter of neurons and how the filters are modulated by network interactions and some stimulus feature. Finally, in the case of strong refractory effects, the mean-field approximations in the generalized linear model become inaccurate; therefore, we introduce a model that captures strong refractoriness, retains all of the easy fitting properties of the standard generalized linear model, and leads to much more accurate approximations of mean firing rates and cross-correlations that retain fine temporal behaviors.

  6. A differential-geometric approach to generalized linear models with grouped predictors

    NARCIS (Netherlands)

    Augugliaro, Luigi; Mineo, Angelo M.; Wit, Ernst C.

    We propose an extension of the differential-geometric least angle regression method to perform sparse group inference in a generalized linear model. An efficient algorithm is proposed to compute the solution curve. The proposed group differential-geometric least angle regression method has important

  7. Estimation of Complex Generalized Linear Mixed Models for Measurement and Growth

    Science.gov (United States)

    Jeon, Minjeong

    2012-01-01

    Maximum likelihood (ML) estimation of generalized linear mixed models (GLMMs) is technically challenging because of the intractable likelihoods that involve high dimensional integrations over random effects. The problem is magnified when the random effects have a crossed design and thus the data cannot be reduced to small independent clusters. A…

  8. Bayesian estimation and hypothesis tests for a circular Generalized Linear Model

    NARCIS (Netherlands)

    Mulder, Kees; Klugkist, Irene

    2017-01-01

    Motivated by a study from cognitive psychology, we develop a Generalized Linear Model for circular data within the Bayesian framework, using the von Mises distribution. Although circular data arise in a wide variety of scientific fields, the number of methods for their analysis is limited. Our model

  9. Bayesian prediction of spatial count data using generalized linear mixed models

    DEFF Research Database (Denmark)

    Christensen, Ole Fredslund; Waagepetersen, Rasmus Plenge

    2002-01-01

    Spatial weed count data are modeled and predicted using a generalized linear mixed model combined with a Bayesian approach and Markov chain Monte Carlo. Informative priors for a data set with sparse sampling are elicited using a previously collected data set with extensive sampling. Furthermore, we...

  10. Generalized linear models with random effects unified analysis via H-likelihood

    CERN Document Server

    Lee, Youngjo; Pawitan, Yudi

    2006-01-01

    Since their introduction in 1972, generalized linear models (GLMs) have proven useful in the generalization of classical normal models. Presenting methods for fitting GLMs with random effects to data, Generalized Linear Models with Random Effects: Unified Analysis via H-likelihood explores a wide range of applications, including combining information over trials (meta-analysis), analysis of frailty models for survival data, genetic epidemiology, and analysis of spatial and temporal models with correlated errors.Written by pioneering authorities in the field, this reference provides an introduction to various theories and examines likelihood inference and GLMs. The authors show how to extend the class of GLMs while retaining as much simplicity as possible. By maximizing and deriving other quantities from h-likelihood, they also demonstrate how to use a single algorithm for all members of the class, resulting in a faster algorithm as compared to existing alternatives. Complementing theory with examples, many of...

  11. Poisson-Jacobi reduction of homogeneous tensors

    International Nuclear Information System (INIS)

    Grabowski, J; Iglesias, D; Marrero, J C; Padron, E; Urbanski, P

    2004-01-01

    The notion of homogeneous tensors is discussed. We show that there is a one-to-one correspondence between multivector fields on a manifold M, homogeneous with respect to a vector field Δ on M, and first-order polydifferential operators on a closed submanifold N of codimension 1 such that Δ is transversal to N. This correspondence relates the Schouten-Nijenhuis bracket of multivector fields on M to the Schouten-Jacobi bracket of first-order polydifferential operators on N and generalizes the Poissonization of Jacobi manifolds. Actually, it can be viewed as a super-Poissonization. This procedure of passing from a homogeneous multivector field to a first-order polydifferential operator can also be understood as a sort of reduction; in the standard case-a half of a Poisson reduction. A dual version of the above correspondence yields in particular the correspondence between Δ-homogeneous symplectic structures on M and contact structures on N

  12. A comparative study of generalized linear mixed modelling and artificial neural network approach for the joint modelling of survival and incidence of Dengue patients in Sri Lanka

    Science.gov (United States)

    Hapugoda, J. C.; Sooriyarachchi, M. R.

    2017-09-01

    Survival time of patients with a disease and the incidence of that particular disease (count) is frequently observed in medical studies with the data of a clustered nature. In many cases, though, the survival times and the count can be correlated in a way that, diseases that occur rarely could have shorter survival times or vice versa. Due to this fact, joint modelling of these two variables will provide interesting and certainly improved results than modelling these separately. Authors have previously proposed a methodology using Generalized Linear Mixed Models (GLMM) by joining the Discrete Time Hazard model with the Poisson Regression model to jointly model survival and count model. As Aritificial Neural Network (ANN) has become a most powerful computational tool to model complex non-linear systems, it was proposed to develop a new joint model of survival and count of Dengue patients of Sri Lanka by using that approach. Thus, the objective of this study is to develop a model using ANN approach and compare the results with the previously developed GLMM model. As the response variables are continuous in nature, Generalized Regression Neural Network (GRNN) approach was adopted to model the data. To compare the model fit, measures such as root mean square error (RMSE), absolute mean error (AME) and correlation coefficient (R) were used. The measures indicate the GRNN model fits the data better than the GLMM model.

  13. Degenerate odd Poisson bracket on Grassmann variables

    International Nuclear Information System (INIS)

    Soroka, V.A.

    2000-01-01

    A linear degenerate odd Poisson bracket (antibracket) realized solely on Grassmann variables is proposed. It is revealed that this bracket has at once three Grassmann-odd nilpotent Δ-like differential operators of the first, second and third orders with respect to the Grassmann derivatives. It is shown that these Δ-like operators, together with the Grassmann-odd nilpotent Casimir function of this bracket, form a finite-dimensional Lie superalgebra

  14. A heteroscedastic generalized linear model with a non-normal speed factor for responses and response times

    NARCIS (Netherlands)

    Molenaar, D.; Bolsinova, M.

    In generalized linear modelling of responses and response times, the observed response time variables are commonly transformed to make their distribution approximately normal. A normal distribution for the transformed response times is desirable as it justifies the linearity and homoscedasticity

  15. Hierarchical shrinkage priors and model fitting for high-dimensional generalized linear models.

    Science.gov (United States)

    Yi, Nengjun; Ma, Shuangge

    2012-11-26

    Abstract Genetic and other scientific studies routinely generate very many predictor variables, which can be naturally grouped, with predictors in the same groups being highly correlated. It is desirable to incorporate the hierarchical structure of the predictor variables into generalized linear models for simultaneous variable selection and coefficient estimation. We propose two prior distributions: hierarchical Cauchy and double-exponential distributions, on coefficients in generalized linear models. The hierarchical priors include both variable-specific and group-specific tuning parameters, thereby not only adopting different shrinkage for different coefficients and different groups but also providing a way to pool the information within groups. We fit generalized linear models with the proposed hierarchical priors by incorporating flexible expectation-maximization (EM) algorithms into the standard iteratively weighted least squares as implemented in the general statistical package R. The methods are illustrated with data from an experiment to identify genetic polymorphisms for survival of mice following infection with Listeria monocytogenes. The performance of the proposed procedures is further assessed via simulation studies. The methods are implemented in a freely available R package BhGLM (http://www.ssg.uab.edu/bhglm/).

  16. Linear electrical circuits. Definitions - General theorems; Circuits electriques lineaires. Definitions - Theoremes generaux

    Energy Technology Data Exchange (ETDEWEB)

    Escane, J.M. [Ecole Superieure d' Electricite, 91 - Gif-sur-Yvette (France)

    2005-04-01

    The first part of this article defines the different elements of an electrical network and the models to represent them. Each model involves the current and the voltage as a function of time. Models involving time functions are simple but their use is not always easy. The Laplace transformation leads to a more convenient form where the variable is no more directly the time. This transformation leads also to the notion of transfer function which is the object of the second part. The third part aims at defining the fundamental operation rules of linear networks, commonly named 'general theorems': linearity principle and superimposition theorem, duality principle, Thevenin theorem, Norton theorem, Millman theorem, triangle-star and star-triangle transformations. These theorems allow to study complex power networks and to simplify the calculations. They are based on hypotheses, the first one is that all networks considered in this article are linear. (J.S.)

  17. Conditional Akaike information under generalized linear and proportional hazards mixed models

    Science.gov (United States)

    Donohue, M. C.; Overholser, R.; Xu, R.; Vaida, F.

    2011-01-01

    We study model selection for clustered data, when the focus is on cluster specific inference. Such data are often modelled using random effects, and conditional Akaike information was proposed in Vaida & Blanchard (2005) and used to derive an information criterion under linear mixed models. Here we extend the approach to generalized linear and proportional hazards mixed models. Outside the normal linear mixed models, exact calculations are not available and we resort to asymptotic approximations. In the presence of nuisance parameters, a profile conditional Akaike information is proposed. Bootstrap methods are considered for their potential advantage in finite samples. Simulations show that the performance of the bootstrap and the analytic criteria are comparable, with bootstrap demonstrating some advantages for larger cluster sizes. The proposed criteria are applied to two cancer datasets to select models when the cluster-specific inference is of interest. PMID:22822261

  18. An analogue of Morse theory for planar linear networks and the generalized Steiner problem

    International Nuclear Information System (INIS)

    Karpunin, G A

    2000-01-01

    A study is made of the generalized Steiner problem: the problem of finding all the locally minimal networks spanning a given boundary set (terminal set). It is proposed to solve this problem by using an analogue of Morse theory developed here for planar linear networks. The space K of all planar linear networks spanning a given boundary set is constructed. The concept of a critical point and its index is defined for the length function l of a planar linear network. It is shown that locally minimal networks are local minima of l on K and are critical points of index 1. The theorem is proved that the sum of the indices of all the critical points is equal to χ(K)=1. This theorem is used to find estimates for the number of locally minimal networks spanning a given boundary set

  19. Sample size and power calculations based on generalized linear mixed models with correlated binary outcomes.

    Science.gov (United States)

    Dang, Qianyu; Mazumdar, Sati; Houck, Patricia R

    2008-08-01

    The generalized linear mixed model (GLIMMIX) provides a powerful technique to model correlated outcomes with different types of distributions. The model can now be easily implemented with SAS PROC GLIMMIX in version 9.1. For binary outcomes, linearization methods of penalized quasi-likelihood (PQL) or marginal quasi-likelihood (MQL) provide relatively accurate variance estimates for fixed effects. Using GLIMMIX based on these linearization methods, we derived formulas for power and sample size calculations for longitudinal designs with attrition over time. We found that the power and sample size estimates depend on the within-subject correlation and the size of random effects. In this article, we present tables of minimum sample sizes commonly used to test hypotheses for longitudinal studies. A simulation study was used to compare the results. We also provide a Web link to the SAS macro that we developed to compute power and sample sizes for correlated binary outcomes.

  20. Linear and nonlinear associations between general intelligence and personality in Project TALENT.

    Science.gov (United States)

    Major, Jason T; Johnson, Wendy; Deary, Ian J

    2014-04-01

    Research on the relations of personality traits to intelligence has primarily been concerned with linear associations. Yet, there are no a priori reasons why linear relations should be expected over nonlinear ones, which represent a much larger set of all possible associations. Using 2 techniques, quadratic and generalized additive models, we tested for linear and nonlinear associations of general intelligence (g) with 10 personality scales from Project TALENT (PT), a nationally representative sample of approximately 400,000 American high school students from 1960, divided into 4 grade samples (Flanagan et al., 1962). We departed from previous studies, including one with PT (Reeve, Meyer, & Bonaccio, 2006), by modeling latent quadratic effects directly, controlling the influence of the common factor in the personality scales, and assuming a direction of effect from g to personality. On the basis of the literature, we made 17 directional hypotheses for the linear and quadratic associations. Of these, 53% were supported in all 4 male grades and 58% in all 4 female grades. Quadratic associations explained substantive variance above and beyond linear effects (mean R² between 1.8% and 3.6%) for Sociability, Maturity, Vigor, and Leadership in males and Sociability, Maturity, and Tidiness in females; linear associations were predominant for other traits. We discuss how suited current theories of the personality-intelligence interface are to explain these associations, and how research on intellectually gifted samples may provide a unique way of understanding them. We conclude that nonlinear models can provide incremental detail regarding personality and intelligence associations. (PsycINFO Database Record (c) 2014 APA, all rights reserved).

  1. A general digital computer procedure for synthesizing linear automatic control systems

    International Nuclear Information System (INIS)

    Cummins, J.D.

    1961-10-01

    The fundamental concepts required for synthesizing a linear automatic control system are considered. A generalized procedure for synthesizing automatic control systems is demonstrated. This procedure has been programmed for the Ferranti Mercury and the IBM 7090 computers. Details of the programmes are given. The procedure uses the linearized set of equations which describe the plant to be controlled as the starting point. Subsequent computations determine the transfer functions between any desired variables. The programmes also compute the root and phase loci for any linear (and some non-linear) configurations in the complex plane, the open loop and closed loop frequency responses of a system, the residues of a function of the complex variable 's' and the time response corresponding to these residues. With these general programmes available the design of 'one point' automatic control systems becomes a routine scientific procedure. Also dynamic assessments of plant may be carried out. Certain classes of multipoint automatic control problems may also be solved with these procedures. Autonomous systems, invariant systems and orthogonal systems may also be studied. (author)

  2. A cautionary note on generalized linear models for covariance of unbalanced longitudinal data

    KAUST Repository

    Huang, Jianhua Z.

    2012-03-01

    Missing data in longitudinal studies can create enormous challenges in data analysis when coupled with the positive-definiteness constraint on a covariance matrix. For complete balanced data, the Cholesky decomposition of a covariance matrix makes it possible to remove the positive-definiteness constraint and use a generalized linear model setup to jointly model the mean and covariance using covariates (Pourahmadi, 2000). However, this approach may not be directly applicable when the longitudinal data are unbalanced, as coherent regression models for the dependence across all times and subjects may not exist. Within the existing generalized linear model framework, we show how to overcome this and other challenges by embedding the covariance matrix of the observed data for each subject in a larger covariance matrix and employing the familiar EM algorithm to compute the maximum likelihood estimates of the parameters and their standard errors. We illustrate and assess the methodology using real data sets and simulations. © 2011 Elsevier B.V.

  3. An Entropy-Based Approach to Path Analysis of Structural Generalized Linear Models: A Basic Idea

    Directory of Open Access Journals (Sweden)

    Nobuoki Eshima

    2015-07-01

    Full Text Available A path analysis method for causal systems based on generalized linear models is proposed by using entropy. A practical example is introduced, and a brief explanation of the entropy coefficient of determination is given. Direct and indirect effects of explanatory variables are discussed as log odds ratios, i.e., relative information, and a method for summarizing the effects is proposed. The example dataset is re-analyzed by using the method.

  4. The regression-calibration method for fitting generalized linear models with additive measurement error

    OpenAIRE

    James W. Hardin; Henrik Schmeidiche; Raymond J. Carroll

    2003-01-01

    This paper discusses and illustrates the method of regression calibration. This is a straightforward technique for fitting models with additive measurement error. We present this discussion in terms of generalized linear models (GLMs) following the notation defined in Hardin and Carroll (2003). Discussion will include specified measurement error, measurement error estimated by replicate error-prone proxies, and measurement error estimated by instrumental variables. The discussion focuses on s...

  5. Synthesis of general linear networks using causal and J-isometric dilations

    International Nuclear Information System (INIS)

    D'Attellis, C.E.

    1977-06-01

    The problem of the synthesis of linear systems characterized by their scattering operator is studied. This problem is considered solved once an adequate dilation for the operator is obtained, from which the synthesis is performed following the method of Saeks (35) and Levan (19). Known results appear sistematized and generalized in this paper, obtaining an unique method of synthesis for different caterories of operators. (Author) [es

  6. A General Construction of Linear Differential Equations with Solutions of Prescribed Properties

    Czech Academy of Sciences Publication Activity Database

    Neuman, František

    2004-01-01

    Roč. 17, č. 1 (2004), s. 71-76 ISSN 0893-9659 R&D Projects: GA AV ČR IAA1019902; GA ČR GA201/99/0295 Institutional research plan: CEZ:AV0Z1019905 Keywords : construction of linear differential equations * prescribed qualitative properties of solutions Subject RIV: BA - General Mathematics Impact factor: 0.414, year: 2004

  7. Non-isothermal Smoluchowski-Poisson equation as a singular limit of the Navier-Stokes-Fourier-Poisson system

    Czech Academy of Sciences Publication Activity Database

    Feireisl, Eduard; Laurençot, P.

    2007-01-01

    Roč. 88, - (2007), s. 325-349 ISSN 0021-7824 R&D Projects: GA ČR GA201/05/0164 Institutional research plan: CEZ:AV0Z10190503 Keywords : Navier-Stokes-Fourier- Poisson system * Smoluchowski- Poisson system * singular limit Subject RIV: BA - General Mathematics Impact factor: 1.118, year: 2007

  8. Interactions in Generalized Linear Models: Theoretical Issues and an Application to Personal Vote-Earning Attributes

    Directory of Open Access Journals (Sweden)

    Tsung-han Tsai

    2013-05-01

    Full Text Available There is some confusion in political science, and the social sciences in general, about the meaning and interpretation of interaction effects in models with non-interval, non-normal outcome variables. Often these terms are casually thrown into a model specification without observing that their presence fundamentally changes the interpretation of the resulting coefficients. This article explains the conditional nature of reported coefficients in models with interactions, defining the necessarily different interpretation required by generalized linear models. Methodological issues are illustrated with an application to voter information structured by electoral systems and resulting legislative behavior and democratic representation in comparative politics.

  9. Generalized Uncertainty Quantification for Linear Inverse Problems in X-ray Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Fowler, Michael James [Clarkson Univ., Potsdam, NY (United States)

    2014-04-25

    In industrial and engineering applications, X-ray radiography has attained wide use as a data collection protocol for the assessment of material properties in cases where direct observation is not possible. The direct measurement of nuclear materials, particularly when they are under explosive or implosive loading, is not feasible, and radiography can serve as a useful tool for obtaining indirect measurements. In such experiments, high energy X-rays are pulsed through a scene containing material of interest, and a detector records a radiograph by measuring the radiation that is not attenuated in the scene. One approach to the analysis of these radiographs is to model the imaging system as an operator that acts upon the object being imaged to produce a radiograph. In this model, the goal is to solve an inverse problem to reconstruct the values of interest in the object, which are typically material properties such as density or areal density. The primary objective in this work is to provide quantitative solutions with uncertainty estimates for three separate applications in X-ray radiography: deconvolution, Abel inversion, and radiation spot shape reconstruction. For each problem, we introduce a new hierarchical Bayesian model for determining a posterior distribution on the unknowns and develop efficient Markov chain Monte Carlo (MCMC) methods for sampling from the posterior. A Poisson likelihood, based on a noise model for photon counts at the detector, is combined with a prior tailored to each application: an edge-localizing prior for deconvolution; a smoothing prior with non-negativity constraints for spot reconstruction; and a full covariance sampling prior based on a Wishart hyperprior for Abel inversion. After developing our methods in a general setting, we demonstrate each model on both synthetically generated datasets, including those from a well known radiation transport code, and real high energy radiographs taken at two U. S. Department of Energy

  10. Linear stability analysis of parallel shear flows for an inviscid generalized two-dimensional fluid system

    International Nuclear Information System (INIS)

    Iwayama, T; Sueyoshi, M; Watanabe, T

    2013-01-01

    The linear stability of parallel shear flows for an inviscid generalized two-dimensional (2D) fluid system, the so-called α turbulence system, is studied. This system is characterized by the relation q = −( − Δ) α/2 ψ between the advected scalar q and the stream function ψ. Here, α is a real number not exceeding 3 and q is referred to as the generalized vorticity. In this study, a sufficient condition for linear stability of parallel shear flows is derived using the conservation of wave activity. A stability analysis is then performed for a sheet vortex that violates the stability condition. The instability of a sheet vortex in the 2D Euler system (α = 2) is referred to as a Kelvin–Helmholtz (KH) instability; such an instability for the generalized 2D fluid system is investigated for 0 3−α for 1 < α < 3, where k is the wavenumber of the perturbation. In contrast, for 0 < α ⩽ 1, the growth rate is infinite. In other words, a transition of the growth rate of the perturbation occurs at α = 1. A physical model for KH instability in the generalized 2D fluid system, which can explain the transition of the growth rate of the perturbation at α = 1, is proposed. (paper)

  11. Poisson hierarchy of discrete strings

    Energy Technology Data Exchange (ETDEWEB)

    Ioannidou, Theodora, E-mail: ti3@auth.gr [Faculty of Civil Engineering, School of Engineering, Aristotle University of Thessaloniki, 54249, Thessaloniki (Greece); Niemi, Antti J., E-mail: Antti.Niemi@physics.uu.se [Department of Physics and Astronomy, Uppsala University, P.O. Box 803, S-75108, Uppsala (Sweden); Laboratoire de Mathematiques et Physique Theorique CNRS UMR 6083, Fédération Denis Poisson, Université de Tours, Parc de Grandmont, F37200, Tours (France); Department of Physics, Beijing Institute of Technology, Haidian District, Beijing 100081 (China)

    2016-01-28

    The Poisson geometry of a discrete string in three dimensional Euclidean space is investigated. For this the Frenet frames are converted into a spinorial representation, the discrete spinor Frenet equation is interpreted in terms of a transfer matrix formalism, and Poisson brackets are introduced in terms of the spinor components. The construction is then generalised, in a self-similar manner, into an infinite hierarchy of Poisson algebras. As an example, the classical Virasoro (Witt) algebra that determines reparametrisation diffeomorphism along a continuous string, is identified as a particular sub-algebra, in the hierarchy of the discrete string Poisson algebra. - Highlights: • Witt (classical Virasoro) algebra is derived in the case of discrete string. • Infinite dimensional hierarchy of Poisson bracket algebras is constructed for discrete strings. • Spinor representation of discrete Frenet equations is developed.

  12. Poisson hierarchy of discrete strings

    International Nuclear Information System (INIS)

    Ioannidou, Theodora; Niemi, Antti J.

    2016-01-01

    The Poisson geometry of a discrete string in three dimensional Euclidean space is investigated. For this the Frenet frames are converted into a spinorial representation, the discrete spinor Frenet equation is interpreted in terms of a transfer matrix formalism, and Poisson brackets are introduced in terms of the spinor components. The construction is then generalised, in a self-similar manner, into an infinite hierarchy of Poisson algebras. As an example, the classical Virasoro (Witt) algebra that determines reparametrisation diffeomorphism along a continuous string, is identified as a particular sub-algebra, in the hierarchy of the discrete string Poisson algebra. - Highlights: • Witt (classical Virasoro) algebra is derived in the case of discrete string. • Infinite dimensional hierarchy of Poisson bracket algebras is constructed for discrete strings. • Spinor representation of discrete Frenet equations is developed.

  13. Unified Einstein-Virasoro master equation in the general non-linear $\\sigma$ model

    CERN Document Server

    De Boer, J

    1997-01-01

    The Virasoro master equation (VME) describes the general affine-Virasoro construction T=L^{ab}J_aJ_b+iD^a \\dif J_a in the operator algebra of the WZW model, where L^{ab} is the inverse inertia tensor and D^a is the improvement vector. In this paper, we generalize this construction to find the general (one-loop) Virasoro construction in the operator algebra of the general non-linear sigma model. The result is a unified Einstein-Virasoro master equation which couples the spacetime spin-two field L^{ab} to the background fields of the sigma model. For a particular solution L_G^{ab}, the unified system reduces to the canonical stress tensors and conventional Einstein equations of the sigma model, and the system reduces to the general affine-Virasoro construction and the VME when the sigma model is taken to be the WZW action. More generally, the unified system describes a space of conformal field theories which is presumably much larger than the sum of the general affine-Virasoro construction and the sigma model w...

  14. Normality of raw data in general linear models: The most widespread myth in statistics

    Science.gov (United States)

    Kery, Marc; Hatfield, Jeff S.

    2003-01-01

    In years of statistical consulting for ecologists and wildlife biologists, by far the most common misconception we have come across has been the one about normality in general linear models. These comprise a very large part of the statistical models used in ecology and include t tests, simple and multiple linear regression, polynomial regression, and analysis of variance (ANOVA) and covariance (ANCOVA). There is a widely held belief that the normality assumption pertains to the raw data rather than to the model residuals. We suspect that this error may also occur in countless published studies, whenever the normality assumption is tested prior to analysis. This may lead to the use of nonparametric alternatives (if there are any), when parametric tests would indeed be appropriate, or to use of transformations of raw data, which may introduce hidden assumptions such as multiplicative effects on the natural scale in the case of log-transformed data. Our aim here is to dispel this myth. We very briefly describe relevant theory for two cases of general linear models to show that the residuals need to be normally distributed if tests requiring normality are to be used, such as t and F tests. We then give two examples demonstrating that the distribution of the response variable may be nonnormal, and yet the residuals are well behaved. We do not go into the issue of how to test normality; instead we display the distributions of response variables and residuals graphically.

  15. Generalized partial linear varying multi-index coefficient model for gene-environment interactions.

    Science.gov (United States)

    Liu, Xu; Gao, Bin; Cui, Yuehua

    2017-03-01

    Epidemiological studies have suggested the joint effect of simultaneous exposures to multiple environments on disease risk. However, how environmental mixtures as a whole jointly modify genetic effect on disease risk is still largely unknown. Given the importance of gene-environment (G×E) interactions on many complex diseases, rigorously assessing the interaction effect between genes and environmental mixtures as a whole could shed novel insights into the etiology of complex diseases. For this purpose, we propose a generalized partial linear varying multi-index coefficient model (GPLVMICM) to capture the genetic effect on disease risk modulated by multiple environments as a whole. GPLVMICM is semiparametric in nature which allows different index loading parameters in different index functions. We estimate the parametric parameters by a profile procedure, and the nonparametric index functions by a B-spline backfitted kernel method. Under some regularity conditions, the proposed parametric and nonparametric estimators are shown to be consistent and asymptotically normal. We propose a generalized likelihood ratio (GLR) test to rigorously assess the linearity of the interaction effect between multiple environments and a gene, while apply a parametric likelihood test to detect linear G×E interaction effect. The finite sample performance of the proposed method is examined through simulation studies and is further illustrated through a real data analysis.

  16. Variable Selection with Prior Information for Generalized Linear Models via the Prior LASSO Method

    Science.gov (United States)

    Jiang, Yuan; He, Yunxiao

    2015-01-01

    LASSO is a popular statistical tool often used in conjunction with generalized linear models that can simultaneously select variables and estimate parameters. When there are many variables of interest, as in current biological and biomedical studies, the power of LASSO can be limited. Fortunately, so much biological and biomedical data have been collected and they may contain useful information about the importance of certain variables. This paper proposes an extension of LASSO, namely, prior LASSO (pLASSO), to incorporate that prior information into penalized generalized linear models. The goal is achieved by adding in the LASSO criterion function an additional measure of the discrepancy between the prior information and the model. For linear regression, the whole solution path of the pLASSO estimator can be found with a procedure similar to the Least Angle Regression (LARS). Asymptotic theories and simulation results show that pLASSO provides significant improvement over LASSO when the prior information is relatively accurate. When the prior information is less reliable, pLASSO shows great robustness to the misspecification. We illustrate the application of pLASSO using a real data set from a genome-wide association study. PMID:27217599

  17. The potential in general linear electrodynamics. Causal structure, propagators and quantization

    Energy Technology Data Exchange (ETDEWEB)

    Siemssen, Daniel [Department of Mathematical Methods in Physics, Faculty of Physics, University of Warsaw (Poland); Pfeifer, Christian [Institute for Theoretical Physics, Leibniz Universitaet Hannover (Germany); Center of Applied Space Technology and Microgravity (ZARM), Universitaet Bremen (Germany)

    2016-07-01

    From an axiomatic point of view, the fundamental input for a theory of electrodynamics are Maxwell's equations dF=0 (or F=dA) and dH=J, and a constitutive law H=F, which relates the field strength 2-form F and the excitation 2-form H. In this talk we consider general linear electrodynamics, the theory of electrodynamics defined by a linear constitutive law. The best known application of this theory is the effective description of electrodynamics inside (linear) media (e.g. birefringence). We analyze the classical theory of the electromagnetic potential A before we use methods familiar from mathematical quantum field theory in curved spacetimes to quantize it. Our analysis of the classical theory contains the derivation of retarded and advanced propagators, the analysis of the causal structure on the basis of the constitutive law (instead of a metric) and a discussion of the classical phase space. This classical analysis sets the stage for the construction of the quantum field algebra and quantum states, including a (generalized) microlocal spectrum condition.

  18. Application of conditional moment tests to model checking for generalized linear models.

    Science.gov (United States)

    Pan, Wei

    2002-06-01

    Generalized linear models (GLMs) are increasingly being used in daily data analysis. However, model checking for GLMs with correlated discrete response data remains difficult. In this paper, through a case study on marginal logistic regression using a real data set, we illustrate the flexibility and effectiveness of using conditional moment tests (CMTs), along with other graphical methods, to do model checking for generalized estimation equation (GEE) analyses. Although CMTs provide an array of powerful diagnostic tests for model checking, they were originally proposed in the econometrics literature and, to our knowledge, have never been applied to GEE analyses. CMTs cover many existing tests, including the (generalized) score test for an omitted covariate, as special cases. In summary, we believe that CMTs provide a class of useful model checking tools.

  19. Orthogonality of the Mean and Error Distribution in Generalized Linear Models.

    Science.gov (United States)

    Huang, Alan; Rathouz, Paul J

    2017-01-01

    We show that the mean-model parameter is always orthogonal to the error distribution in generalized linear models. Thus, the maximum likelihood estimator of the mean-model parameter will be asymptotically efficient regardless of whether the error distribution is known completely, known up to a finite vector of parameters, or left completely unspecified, in which case the likelihood is taken to be an appropriate semiparametric likelihood. Moreover, the maximum likelihood estimator of the mean-model parameter will be asymptotically independent of the maximum likelihood estimator of the error distribution. This generalizes some well-known results for the special cases of normal, gamma and multinomial regression models, and, perhaps more interestingly, suggests that asymptotically efficient estimation and inferences can always be obtained if the error distribution is nonparametrically estimated along with the mean. In contrast, estimation and inferences using misspecified error distributions or variance functions are generally not efficient.

  20. Non-cooperative stochastic differential game theory of generalized Markov jump linear systems

    CERN Document Server

    Zhang, Cheng-ke; Zhou, Hai-ying; Bin, Ning

    2017-01-01

    This book systematically studies the stochastic non-cooperative differential game theory of generalized linear Markov jump systems and its application in the field of finance and insurance. The book is an in-depth research book of the continuous time and discrete time linear quadratic stochastic differential game, in order to establish a relatively complete framework of dynamic non-cooperative differential game theory. It uses the method of dynamic programming principle and Riccati equation, and derives it into all kinds of existence conditions and calculating method of the equilibrium strategies of dynamic non-cooperative differential game. Based on the game theory method, this book studies the corresponding robust control problem, especially the existence condition and design method of the optimal robust control strategy. The book discusses the theoretical results and its applications in the risk control, option pricing, and the optimal investment problem in the field of finance and insurance, enriching the...

  1. Generalized Degrees of Freedom and Adaptive Model Selection in Linear Mixed-Effects Models.

    Science.gov (United States)

    Zhang, Bo; Shen, Xiaotong; Mumford, Sunni L

    2012-03-01

    Linear mixed-effects models involve fixed effects, random effects and covariance structure, which require model selection to simplify a model and to enhance its interpretability and predictability. In this article, we develop, in the context of linear mixed-effects models, the generalized degrees of freedom and an adaptive model selection procedure defined by a data-driven model complexity penalty. Numerically, the procedure performs well against its competitors not only in selecting fixed effects but in selecting random effects and covariance structure as well. Theoretically, asymptotic optimality of the proposed methodology is established over a class of information criteria. The proposed methodology is applied to the BioCycle study, to determine predictors of hormone levels among premenopausal women and to assess variation in hormone levels both between and within women across the menstrual cycle.

  2. Use of generalized linear mixed models for network meta-analysis.

    Science.gov (United States)

    Tu, Yu-Kang

    2014-10-01

    In the past decade, a new statistical method-network meta-analysis-has been developed to address limitations in traditional pairwise meta-analysis. Network meta-analysis incorporates all available evidence into a general statistical framework for comparisons of multiple treatments. Bayesian network meta-analysis, as proposed by Lu and Ades, also known as "mixed treatments comparisons," provides a flexible modeling framework to take into account complexity in the data structure. This article shows how to implement the Lu and Ades model in the frequentist generalized linear mixed model. Two examples are provided to demonstrate how centering the covariates for random effects estimation within each trial can yield correct estimation of random effects. Moreover, under the correct specification for random effects estimation, the dummy coding and contrast basic parameter coding schemes will yield the same results. It is straightforward to incorporate covariates, such as moderators and confounders, into the generalized linear mixed model to conduct meta-regression for multiple treatment comparisons. Moreover, this approach may be extended easily to other types of outcome variables, such as continuous, counts, and multinomial. © The Author(s) 2014.

  3. Assessing correlation of clustered mixed outcomes from a multivariate generalized linear mixed model.

    Science.gov (United States)

    Chen, Hsiang-Chun; Wehrly, Thomas E

    2015-02-20

    The classic concordance correlation coefficient measures the agreement between two variables. In recent studies, concordance correlation coefficients have been generalized to deal with responses from a distribution from the exponential family using the univariate generalized linear mixed model. Multivariate data arise when responses on the same unit are measured repeatedly by several methods. The relationship among these responses is often of interest. In clustered mixed data, the correlation could be present between repeated measurements either within the same observer or between different methods on the same subjects. Indices for measuring such association are needed. This study proposes a series of indices, namely, intra-correlation, inter-correlation, and total correlation coefficients to measure the correlation under various circumstances in a multivariate generalized linear model, especially for joint modeling of clustered count and continuous outcomes. The proposed indices are natural extensions of the concordance correlation coefficient. We demonstrate the methodology with simulation studies. A case example of osteoarthritis study is provided to illustrate the use of these proposed indices. Copyright © 2014 John Wiley & Sons, Ltd.

  4. Random generalized linear model: a highly accurate and interpretable ensemble predictor.

    Science.gov (United States)

    Song, Lin; Langfelder, Peter; Horvath, Steve

    2013-01-16

    Ensemble predictors such as the random forest are known to have superior accuracy but their black-box predictions are difficult to interpret. In contrast, a generalized linear model (GLM) is very interpretable especially when forward feature selection is used to construct the model. However, forward feature selection tends to overfit the data and leads to low predictive accuracy. Therefore, it remains an important research goal to combine the advantages of ensemble predictors (high accuracy) with the advantages of forward regression modeling (interpretability). To address this goal several articles have explored GLM based ensemble predictors. Since limited evaluations suggested that these ensemble predictors were less accurate than alternative predictors, they have found little attention in the literature. Comprehensive evaluations involving hundreds of genomic data sets, the UCI machine learning benchmark data, and simulations are used to give GLM based ensemble predictors a new and careful look. A novel bootstrap aggregated (bagged) GLM predictor that incorporates several elements of randomness and instability (random subspace method, optional interaction terms, forward variable selection) often outperforms a host of alternative prediction methods including random forests and penalized regression models (ridge regression, elastic net, lasso). This random generalized linear model (RGLM) predictor provides variable importance measures that can be used to define a "thinned" ensemble predictor (involving few features) that retains excellent predictive accuracy. RGLM is a state of the art predictor that shares the advantages of a random forest (excellent predictive accuracy, feature importance measures, out-of-bag estimates of accuracy) with those of a forward selected generalized linear model (interpretability). These methods are implemented in the freely available R software package randomGLM.

  5. Generalized Coherent States of a Particle in a Time-Dependent Linear Potential

    International Nuclear Information System (INIS)

    Krache, L.; Maamache, M.; Saadi, Y.; Beniaiche, A.

    2009-01-01

    We derive, with an invariant operator method and unitary transformation approach, that the Schrödinger equation with a time-dependent linear potential possesses an infinite string of shape-preseving wave-packet states |φα,λ(t)) having classical motion. The qualitative properties of the invariant eigenvalue spectrum (discrete or continuous) are described separately for the different values of the frequency ω of a harmonic oscillator. It is also shown that, for a discrete eigenvalue spectrum, the states |φα,n(t)) could be obtained from the coherent state |φα,0(t)). (general)

  6. A generalization of Dirac non-linear electrodynamics, and spinning charged particles

    International Nuclear Information System (INIS)

    Rodrigues Junior, W.A.; Vaz Junior, J.; Recami, E.

    1992-08-01

    The Dirac non-linear electrodynamics is generalized by introducing two potentials (namely, the vector potential a and the pseudo-vector potential γ 5 B of the electromagnetic theory with charges and magnetic monopoles), and by imposing the pseudoscalar part of the product W W * to BE zero, with W = A + γ 5 B. Also, is demonstrated that the field equations of such a theory posses a soliton-like solution which can represent a priori a charged particle. (L.C.J.A.)

  7. Unimodularity criteria for Poisson structures on foliated manifolds

    Science.gov (United States)

    Pedroza, Andrés; Velasco-Barreras, Eduardo; Vorobiev, Yury

    2018-03-01

    We study the behavior of the modular class of an orientable Poisson manifold and formulate some unimodularity criteria in the semilocal context, around a (singular) symplectic leaf. Our results generalize some known unimodularity criteria for regular Poisson manifolds related to the notion of the Reeb class. In particular, we show that the unimodularity of the transverse Poisson structure of the leaf is a necessary condition for the semilocal unimodular property. Our main tool is an explicit formula for a bigraded decomposition of modular vector fields of a coupling Poisson structure on a foliated manifold. Moreover, we also exploit the notion of the modular class of a Poisson foliation and its relationship with the Reeb class.

  8. Detecting treatment-subgroup interactions in clustered data with generalized linear mixed-effects model trees.

    Science.gov (United States)

    Fokkema, M; Smits, N; Zeileis, A; Hothorn, T; Kelderman, H

    2017-10-25

    Identification of subgroups of patients for whom treatment A is more effective than treatment B, and vice versa, is of key importance to the development of personalized medicine. Tree-based algorithms are helpful tools for the detection of such interactions, but none of the available algorithms allow for taking into account clustered or nested dataset structures, which are particularly common in psychological research. Therefore, we propose the generalized linear mixed-effects model tree (GLMM tree) algorithm, which allows for the detection of treatment-subgroup interactions, while accounting for the clustered structure of a dataset. The algorithm uses model-based recursive partitioning to detect treatment-subgroup interactions, and a GLMM to estimate the random-effects parameters. In a simulation study, GLMM trees show higher accuracy in recovering treatment-subgroup interactions, higher predictive accuracy, and lower type II error rates than linear-model-based recursive partitioning and mixed-effects regression trees. Also, GLMM trees show somewhat higher predictive accuracy than linear mixed-effects models with pre-specified interaction effects, on average. We illustrate the application of GLMM trees on an individual patient-level data meta-analysis on treatments for depression. We conclude that GLMM trees are a promising exploratory tool for the detection of treatment-subgroup interactions in clustered datasets.

  9. To transform or not to transform: using generalized linear mixed models to analyse reaction time data

    Science.gov (United States)

    Lo, Steson; Andrews, Sally

    2015-01-01

    Linear mixed-effect models (LMMs) are being increasingly widely used in psychology to analyse multi-level research designs. This feature allows LMMs to address some of the problems identified by Speelman and McGann (2013) about the use of mean data, because they do not average across individual responses. However, recent guidelines for using LMM to analyse skewed reaction time (RT) data collected in many cognitive psychological studies recommend the application of non-linear transformations to satisfy assumptions of normality. Uncritical adoption of this recommendation has important theoretical implications which can yield misleading conclusions. For example, Balota et al. (2013) showed that analyses of raw RT produced additive effects of word frequency and stimulus quality on word identification, which conflicted with the interactive effects observed in analyses of transformed RT. Generalized linear mixed-effect models (GLMM) provide a solution to this problem by satisfying normality assumptions without the need for transformation. This allows differences between individuals to be properly assessed, using the metric most appropriate to the researcher's theoretical context. We outline the major theoretical decisions involved in specifying a GLMM, and illustrate them by reanalysing Balota et al.'s datasets. We then consider the broader benefits of using GLMM to investigate individual differences. PMID:26300841

  10. Prescription-induced jump distributions in multiplicative Poisson processes

    Science.gov (United States)

    Suweis, Samir; Porporato, Amilcare; Rinaldo, Andrea; Maritan, Amos

    2011-06-01

    Generalized Langevin equations (GLE) with multiplicative white Poisson noise pose the usual prescription dilemma leading to different evolution equations (master equations) for the probability distribution. Contrary to the case of multiplicative Gaussian white noise, the Stratonovich prescription does not correspond to the well-known midpoint (or any other intermediate) prescription. By introducing an inertial term in the GLE, we show that the Itô and Stratonovich prescriptions naturally arise depending on two time scales, one induced by the inertial term and the other determined by the jump event. We also show that, when the multiplicative noise is linear in the random variable, one prescription can be made equivalent to the other by a suitable transformation in the jump probability distribution. We apply these results to a recently proposed stochastic model describing the dynamics of primary soil salinization, in which the salt mass balance within the soil root zone requires the analysis of different prescriptions arising from the resulting stochastic differential equation forced by multiplicative white Poisson noise, the features of which are tailored to the characters of the daily precipitation. A method is finally suggested to infer the most appropriate prescription from the data.

  11. Prospects of measuring general Higgs couplings at e{sup +}e{sup -} linear colliders

    Energy Technology Data Exchange (ETDEWEB)

    Hagiwara, K. [KEK, Ibaraki (Japan). Theory Group; Ishihara, S. [KEK, Ibaraki (Japan). Theory Group; Department of Physics, Hyogo University of Education, 941-1 Shimokume, Yashiro, Kato, Hyogo 673-1494 (Japan); Kamoshita, J. [Department of Physics, Ochanomizu University, 2-1-1 Otsuka, Bunkyo, Tokyo 112-8610 (Japan); Kniehl, B.A. [II. Institut fuer Theoretische Physik, Universitaet Hamburg, Luruper Chaussee 149, 22761 Hamburg (Germany)

    2000-06-01

    We examine how accurately the general HZV couplings, with V=Z{gamma}, may be determined by studying e{sup +}e{sup -}{yields}Hf anti f processes at future e{sup +}e{sup -} linear colliders. By using the optimal-observable method, which makes use of all available experimental information, we find out which combinations of the various HZV coupling terms may be constrained most efficiently with high luminosity. We also assess the benefits of measuring the tau-lepton helicities, identifying the bottom-hadron charges, polarizing the electron beam and running at two different collider energies. The HZZ couplings are generally found to be well constrained, even without these options, while the HZ{gamma} couplings are not. The constraints on the latter may be significantly improved by beam polarization. (orig.)

  12. Vector generalized linear and additive models with an implementation in R

    CERN Document Server

    Yee, Thomas W

    2015-01-01

    This book presents a statistical framework that expands generalized linear models (GLMs) for regression modelling. The framework shared in this book allows analyses based on many semi-traditional applied statistics models to be performed as a coherent whole. This is possible through the approximately half-a-dozen major classes of statistical models included in the book and the software infrastructure component, which makes the models easily operable.    The book’s methodology and accompanying software (the extensive VGAM R package) are directed at these limitations, and this is the first time the methodology and software are covered comprehensively in one volume. Since their advent in 1972, GLMs have unified important distributions under a single umbrella with enormous implications. The demands of practical data analysis, however, require a flexibility that GLMs do not have. Data-driven GLMs, in the form of generalized additive models (GAMs), are also largely confined to the exponential family. This book ...

  13. A guide to developing resource selection functions from telemetry data using generalized estimating equations and generalized linear mixed models

    Directory of Open Access Journals (Sweden)

    Nicola Koper

    2012-03-01

    Full Text Available Resource selection functions (RSF are often developed using satellite (ARGOS or Global Positioning System (GPS telemetry datasets, which provide a large amount of highly correlated data. We discuss and compare the use of generalized linear mixed-effects models (GLMM and generalized estimating equations (GEE for using this type of data to develop RSFs. GLMMs directly model differences among caribou, while GEEs depend on an adjustment of the standard error to compensate for correlation of data points within individuals. Empirical standard errors, rather than model-based standard errors, must be used with either GLMMs or GEEs when developing RSFs. There are several important differences between these approaches; in particular, GLMMs are best for producing parameter estimates that predict how management might influence individuals, while GEEs are best for predicting how management might influence populations. As the interpretation, value, and statistical significance of both types of parameter estimates differ, it is important that users select the appropriate analytical method. We also outline the use of k-fold cross validation to assess fit of these models. Both GLMMs and GEEs hold promise for developing RSFs as long as they are used appropriately.

  14. Avoiding negative populations in explicit Poisson tau-leaping.

    Science.gov (United States)

    Cao, Yang; Gillespie, Daniel T; Petzold, Linda R

    2005-08-01

    The explicit tau-leaping procedure attempts to speed up the stochastic simulation of a chemically reacting system by approximating the number of firings of each reaction channel during a chosen time increment tau as a Poisson random variable. Since the Poisson random variable can have arbitrarily large sample values, there is always the possibility that this procedure will cause one or more reaction channels to fire so many times during tau that the population of some reactant species will be driven negative. Two recent papers have shown how that unacceptable occurrence can be avoided by replacing the Poisson random variables with binomial random variables, whose values are naturally bounded. This paper describes a modified Poisson tau-leaping procedure that also avoids negative populations, but is easier to implement than the binomial procedure. The new Poisson procedure also introduces a second control parameter, whose value essentially dials the procedure from the original Poisson tau-leaping at one extreme to the exact stochastic simulation algorithm at the other; therefore, the modified Poisson procedure will generally be more accurate than the original Poisson procedure.

  15. Robust-BD Estimation and Inference for General Partially Linear Models

    Directory of Open Access Journals (Sweden)

    Chunming Zhang

    2017-11-01

    Full Text Available The classical quadratic loss for the partially linear model (PLM and the likelihood function for the generalized PLM are not resistant to outliers. This inspires us to propose a class of “robust-Bregman divergence (BD” estimators of both the parametric and nonparametric components in the general partially linear model (GPLM, which allows the distribution of the response variable to be partially specified, without being fully known. Using the local-polynomial function estimation method, we propose a computationally-efficient procedure for obtaining “robust-BD” estimators and establish the consistency and asymptotic normality of the “robust-BD” estimator of the parametric component β o . For inference procedures of β o in the GPLM, we show that the Wald-type test statistic W n constructed from the “robust-BD” estimators is asymptotically distribution free under the null, whereas the likelihood ratio-type test statistic Λ n is not. This provides an insight into the distinction from the asymptotic equivalence (Fan and Huang 2005 between W n and Λ n in the PLM constructed from profile least-squares estimators using the non-robust quadratic loss. Numerical examples illustrate the computational effectiveness of the proposed “robust-BD” estimators and robust Wald-type test in the appearance of outlying observations.

  16. Testing concordance of instrumental variable effects in generalized linear models with application to Mendelian randomization

    Science.gov (United States)

    Dai, James Y.; Chan, Kwun Chuen Gary; Hsu, Li

    2014-01-01

    Instrumental variable regression is one way to overcome unmeasured confounding and estimate causal effect in observational studies. Built on structural mean models, there has been considerale work recently developed for consistent estimation of causal relative risk and causal odds ratio. Such models can sometimes suffer from identification issues for weak instruments. This hampered the applicability of Mendelian randomization analysis in genetic epidemiology. When there are multiple genetic variants available as instrumental variables, and causal effect is defined in a generalized linear model in the presence of unmeasured confounders, we propose to test concordance between instrumental variable effects on the intermediate exposure and instrumental variable effects on the disease outcome, as a means to test the causal effect. We show that a class of generalized least squares estimators provide valid and consistent tests of causality. For causal effect of a continuous exposure on a dichotomous outcome in logistic models, the proposed estimators are shown to be asymptotically conservative. When the disease outcome is rare, such estimators are consistent due to the log-linear approximation of the logistic function. Optimality of such estimators relative to the well-known two-stage least squares estimator and the double-logistic structural mean model is further discussed. PMID:24863158

  17. Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear model.

    Directory of Open Access Journals (Sweden)

    David T Redden

    2006-08-01

    Full Text Available Individual genetic admixture estimates, determined both across the genome and at specific genomic regions, have been proposed for use in identifying specific genomic regions harboring loci influencing phenotypes in regional admixture mapping (RAM. Estimates of individual ancestry can be used in structured association tests (SAT to reduce confounding induced by various forms of population substructure. Although presented as two distinct approaches, we provide a conceptual framework in which both RAM and SAT are special cases of a more general linear model. We clarify which variables are sufficient to condition upon in order to prevent spurious associations and also provide a simple closed form "semiparametric" method of evaluating the reliability of individual admixture estimates. An estimate of the reliability of individual admixture estimates is required to make an inherent errors-in-variables problem tractable. Casting RAM and SAT methods as a general linear model offers enormous flexibility enabling application to a rich set of phenotypes, populations, covariates, and situations, including interaction terms and multilocus models. This approach should allow far wider use of RAM and SAT, often using standard software, in addressing admixture as either a confounder of association studies or a tool for finding loci influencing complex phenotypes in species as diverse as plants, humans, and nonhuman animals.

  18. Action-angle variables and a KAM theorem for b-Poisson manifolds

    OpenAIRE

    Kiesenhofer, Anna; Miranda Galcerán, Eva; Scott, Geoffrey

    2015-01-01

    In this article we prove an action-angle theorem for b-integrable systems on b-Poisson manifolds improving the action-angle theorem contained in [14] for general Poisson manifolds in this setting. As an application, we prove a KAM-type theorem for b-Poisson manifolds. (C) 2015 Elsevier Masson SAS. All rights reserved.

  19. Coordination of Conditional Poisson Samples

    Directory of Open Access Journals (Sweden)

    Grafström Anton

    2015-12-01

    Full Text Available Sample coordination seeks to maximize or to minimize the overlap of two or more samples. The former is known as positive coordination, and the latter as negative coordination. Positive coordination is mainly used for estimation purposes and to reduce data collection costs. Negative coordination is mainly performed to diminish the response burden of the sampled units. Poisson sampling design with permanent random numbers provides an optimum coordination degree of two or more samples. The size of a Poisson sample is, however, random. Conditional Poisson (CP sampling is a modification of the classical Poisson sampling that produces a fixed-size πps sample. We introduce two methods to coordinate Conditional Poisson samples over time or simultaneously. The first one uses permanent random numbers and the list-sequential implementation of CP sampling. The second method uses a CP sample in the first selection and provides an approximate one in the second selection because the prescribed inclusion probabilities are not respected exactly. The methods are evaluated using the size of the expected sample overlap, and are compared with their competitors using Monte Carlo simulation. The new methods provide a good coordination degree of two samples, close to the performance of Poisson sampling with permanent random numbers.

  20. On the poisson's ratio of the nucleus pulposus.

    Science.gov (United States)

    Farrell, M D; Riches, P E

    2013-10-01

    Existing experimental data on the Poisson's ratio of nucleus pulposus (NP) tissue is limited. This study aims to determine whether the Poisson's ratio of NP tissue is strain-dependent, strain-rate-dependent, or varies with axial location in the disk. Thirty-two cylindrical plugs of bovine tail NP tissue were subjected to ramp-hold unconfined compression to 20% axial strain in 5% increments, at either 30 μm/s or 0.3 μm/s ramp speeds and the radial displacement determined using biaxial video extensometry. Following radial recoil, the true Poisson's ratio of the solid phase of NP tissue increased linearly with increasing strain and demonstrated strain-rate dependency. The latter finding suggests that the solid matrix undergoes stress relaxation during the test. For small strains, we suggest a Poisson's ratio of 0.125 to be used in biphasic models of the intervertebral disk.

  1. Algebraic properties of compatible Poisson brackets

    Science.gov (United States)

    Zhang, Pumei

    2014-05-01

    We discuss algebraic properties of a pencil generated by two compatible Poisson tensors A( x) and B( x). From the algebraic viewpoint this amounts to studying the properties of a pair of skew-symmetric bilinear forms A and B defined on a finite-dimensional vector space. We describe the Lie group G P of linear automorphisms of the pencil P = { A + λB}. In particular, we obtain an explicit formula for the dimension of G P and discuss some other algebraic properties such as solvability and Levi-Malcev decomposition.

  2. Efficient semiparametric estimation in generalized partially linear additive models for longitudinal/clustered data

    KAUST Repository

    Cheng, Guang

    2014-02-01

    We consider efficient estimation of the Euclidean parameters in a generalized partially linear additive models for longitudinal/clustered data when multiple covariates need to be modeled nonparametrically, and propose an estimation procedure based on a spline approximation of the nonparametric part of the model and the generalized estimating equations (GEE). Although the model in consideration is natural and useful in many practical applications, the literature on this model is very limited because of challenges in dealing with dependent data for nonparametric additive models. We show that the proposed estimators are consistent and asymptotically normal even if the covariance structure is misspecified. An explicit consistent estimate of the asymptotic variance is also provided. Moreover, we derive the semiparametric efficiency score and information bound under general moment conditions. By showing that our estimators achieve the semiparametric information bound, we effectively establish their efficiency in a stronger sense than what is typically considered for GEE. The derivation of our asymptotic results relies heavily on the empirical processes tools that we develop for the longitudinal/clustered data. Numerical results are used to illustrate the finite sample performance of the proposed estimators. © 2014 ISI/BS.

  3. An Efficient Test for Gene-Environment Interaction in Generalized Linear Mixed Models with Family Data.

    Science.gov (United States)

    Mazo Lopera, Mauricio A; Coombes, Brandon J; de Andrade, Mariza

    2017-09-27

    Gene-environment (GE) interaction has important implications in the etiology of complex diseases that are caused by a combination of genetic factors and environment variables. Several authors have developed GE analysis in the context of independent subjects or longitudinal data using a gene-set. In this paper, we propose to analyze GE interaction for discrete and continuous phenotypes in family studies by incorporating the relatedness among the relatives for each family into a generalized linear mixed model (GLMM) and by using a gene-based variance component test. In addition, we deal with collinearity problems arising from linkage disequilibrium among single nucleotide polymorphisms (SNPs) by considering their coefficients as random effects under the null model estimation. We show that the best linear unbiased predictor (BLUP) of such random effects in the GLMM is equivalent to the ridge regression estimator. This equivalence provides a simple method to estimate the ridge penalty parameter in comparison to other computationally-demanding estimation approaches based on cross-validation schemes. We evaluated the proposed test using simulation studies and applied it to real data from the Baependi Heart Study consisting of 76 families. Using our approach, we identified an interaction between BMI and the Peroxisome Proliferator Activated Receptor Gamma ( PPARG ) gene associated with diabetes.

  4. An Efficient Test for Gene-Environment Interaction in Generalized Linear Mixed Models with Family Data

    Directory of Open Access Journals (Sweden)

    Mauricio A. Mazo Lopera

    2017-09-01

    Full Text Available Gene-environment (GE interaction has important implications in the etiology of complex diseases that are caused by a combination of genetic factors and environment variables. Several authors have developed GE analysis in the context of independent subjects or longitudinal data using a gene-set. In this paper, we propose to analyze GE interaction for discrete and continuous phenotypes in family studies by incorporating the relatedness among the relatives for each family into a generalized linear mixed model (GLMM and by using a gene-based variance component test. In addition, we deal with collinearity problems arising from linkage disequilibrium among single nucleotide polymorphisms (SNPs by considering their coefficients as random effects under the null model estimation. We show that the best linear unbiased predictor (BLUP of such random effects in the GLMM is equivalent to the ridge regression estimator. This equivalence provides a simple method to estimate the ridge penalty parameter in comparison to other computationally-demanding estimation approaches based on cross-validation schemes. We evaluated the proposed test using simulation studies and applied it to real data from the Baependi Heart Study consisting of 76 families. Using our approach, we identified an interaction between BMI and the Peroxisome Proliferator Activated Receptor Gamma (PPARG gene associated with diabetes.

  5. A finite element Poisson solver for gyrokinetic particle simulations in a global field aligned mesh

    International Nuclear Information System (INIS)

    Nishimura, Y.; Lin, Z.; Lewandowski, J.L.V.; Ethier, S.

    2006-01-01

    A new finite element Poisson solver is developed and applied to a global gyrokinetic toroidal code (GTC) which employs the field aligned mesh and thus a logically non-rectangular grid in a general geometry. Employing test cases where the analytical solutions are known, the finite element solver has been verified. The CPU time scaling versus the matrix size employing portable, extensible toolkit for scientific computation (PETSc) to solve the sparse matrix is promising. Taking the ion temperature gradient modes (ITG) as an example, the solution from the new finite element solver has been compared to the solution from the original GTC's iterative solver which is only efficient for adiabatic electrons. Linear and nonlinear simulation results from the two different forms of the gyrokinetic Poisson equation (integral form and the differential form) coincide each other. The new finite element solver enables the implementation of advanced kinetic electron models for global electromagnetic simulations

  6. Stability of Exponential Euler Method for Stochastic Systems under Poisson White Noise Excitations

    Science.gov (United States)

    Li, Longsuo; Zhang, Yu

    2014-12-01

    The stability of stochastic systems under Poisson white noise excitations which based on the quantum theory is investigated in this paper. In general, the exact solution of the most of the stochastic systems with jumps is not easy to get. So it is very necessary to investigate the numerical solution of equations. On the one hand, exponential Euler method is applied to study stochastic delay differential equations, we can find the sufficient conditions for keeping mean square stability by investigating numerical method of systems. Through the comparison, we get the step-size of this method which is longer than the Euler-Maruyama method. On the other hand, mean square exponential stability of exponential Euler method for semi-linear stochastic delay differential equations under Poisson white noise excitations is confirmed.

  7. Perceived Resources as a Predictor of Satisfaction with Food-Related Life among Chilean Elderly: An Approach with Generalized Linear Models.

    Science.gov (United States)

    Lobos, G; Schnettler, B; Grunert, K G; Adasme, C

    2017-01-01

    The main objective of this study is to show why perceived resources are a strong predictor of satisfaction with food-related life in Chilean older adults. Design, sampling and participants: A survey was conducted in rural and urban areas in 30 communes of the Maule Region with 785 participants over 60 years of age who live in their own homes. The Satisfaction with Food-related Life (SWFL) scale was used. Generalized linear models (GLM) were used for the regression analysis. The results led to different considerations: First, older adults' perceived levels of resources are a good reflection of their actual levels of resources. Second, the individuals rated the sum of the perceived resources as 'highly important' to explain older adults' satisfaction with food-related life. Third, SWFL was predicted by satisfaction with economic situation, family importance, quantity of domestic household goods and a relative health indicator. Fourth, older adults who believe they have more resources compared to others are more satisfied with their food-related life. Finally, Poisson and binomial logistic models showed that the sum of perceived resources significantly increased the prediction of SWFL. The main conclusion is that perceived personal resources are a strong predictor of SWFL in Chilean older adults.

  8. A distributed-memory hierarchical solver for general sparse linear systems

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Chao [Stanford Univ., CA (United States). Inst. for Computational and Mathematical Engineering; Pouransari, Hadi [Stanford Univ., CA (United States). Dept. of Mechanical Engineering; Rajamanickam, Sivasankaran [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Center for Computing Research; Boman, Erik G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Center for Computing Research; Darve, Eric [Stanford Univ., CA (United States). Inst. for Computational and Mathematical Engineering and Dept. of Mechanical Engineering

    2017-12-20

    We present a parallel hierarchical solver for general sparse linear systems on distributed-memory machines. For large-scale problems, this fully algebraic algorithm is faster and more memory-efficient than sparse direct solvers because it exploits the low-rank structure of fill-in blocks. Depending on the accuracy of low-rank approximations, the hierarchical solver can be used either as a direct solver or as a preconditioner. The parallel algorithm is based on data decomposition and requires only local communication for updating boundary data on every processor. Moreover, the computation-to-communication ratio of the parallel algorithm is approximately the volume-to-surface-area ratio of the subdomain owned by every processor. We also provide various numerical results to demonstrate the versatility and scalability of the parallel algorithm.

  9. Regional differences of outpatient physician supply as a theoretical economic and empirical generalized linear model.

    Science.gov (United States)

    Scholz, Stefan; Graf von der Schulenburg, Johann-Matthias; Greiner, Wolfgang

    2015-11-17

    Regional differences in physician supply can be found in many health care systems, regardless of their organizational and financial structure. A theoretical model is developed for the physicians' decision on office allocation, covering demand-side factors and a consumption time function. To test the propositions following the theoretical model, generalized linear models were estimated to explain differences in 412 German districts. Various factors found in the literature were included to control for physicians' regional preferences. Evidence in favor of the first three propositions of the theoretical model could be found. Specialists show a stronger association to higher populated districts than GPs. Although indicators for regional preferences are significantly correlated with physician density, their coefficients are not as high as population density. If regional disparities should be addressed by political actions, the focus should be to counteract those parameters representing physicians' preferences in over- and undersupplied regions.

  10. General theories of linear gravitational perturbations to a Schwarzschild black hole

    Science.gov (United States)

    Tattersall, Oliver J.; Ferreira, Pedro G.; Lagos, Macarena

    2018-02-01

    We use the covariant formulation proposed by Tattersall, Lagos, and Ferreira [Phys. Rev. D 96, 064011 (2017), 10.1103/PhysRevD.96.064011] to analyze the structure of linear perturbations about a spherically symmetric background in different families of gravity theories, and hence study how quasinormal modes of perturbed black holes may be affected by modifications to general relativity. We restrict ourselves to single-tensor, scalar-tensor and vector-tensor diffeomorphism-invariant gravity models in a Schwarzschild black hole background. We show explicitly the full covariant form of the quadratic actions in such cases, which allow us to then analyze odd parity (axial) and even parity (polar) perturbations simultaneously in a straightforward manner.

  11. Generalizing, optimizing, and inventing numerical algorithms for the fractional Fourier, Fresnel, and linear canonical transforms

    Science.gov (United States)

    Hennelly, Bryan M.; Sheridan, John T.

    2005-05-01

    By use of matrix-based techniques it is shown how the space-bandwidth product (SBP) of a signal, as indicated by the location of the signal energy in the Wigner distribution function, can be tracked through any quadratic-phase optical system whose operation is described by the linear canonical transform. Then, applying the regular uniform sampling criteria imposed by the SBP and linking the criteria explicitly to a decomposition of the optical matrix of the system, it is shown how numerical algorithms (employing interpolation and decimation), which exhibit both invertibility and additivity, can be implemented. Algorithms appearing in the literature for a variety of transforms (Fresnel, fractional Fourier) are shown to be special cases of our general approach. The method is shown to allow the existing algorithms to be optimized and is also shown to permit the invention of many new algorithms.

  12. A Fuzzy Approach Using Generalized Dinkelbach’s Algorithm for Multiobjective Linear Fractional Transportation Problem

    Directory of Open Access Journals (Sweden)

    Nurdan Cetin

    2014-01-01

    Full Text Available We consider a multiobjective linear fractional transportation problem (MLFTP with several fractional criteria, such as, the maximization of the transport profitability like profit/cost or profit/time, and its two properties are source and destination. Our aim is to introduce MLFTP which has not been studied in literature before and to provide a fuzzy approach which obtain a compromise Pareto-optimal solution for this problem. To do this, first, we present a theorem which shows that MLFTP is always solvable. And then, reducing MLFTP to the Zimmermann’s “min” operator model which is the max-min problem, we construct Generalized Dinkelbach’s Algorithm for solving the obtained problem. Furthermore, we provide an illustrative numerical example to explain this fuzzy approach.

  13. Dynamic Average Consensus and Consensusability of General Linear Multiagent Systems with Random Packet Dropout

    Directory of Open Access Journals (Sweden)

    Wen-Min Zhou

    2013-01-01

    Full Text Available This paper is concerned with the consensus problem of general linear discrete-time multiagent systems (MASs with random packet dropout that happens during information exchange between agents. The packet dropout phenomenon is characterized as being a Bernoulli random process. A distributed consensus protocol with weighted graph is proposed to address the packet dropout phenomenon. Through introducing a new disagreement vector, a new framework is established to solve the consensus problem. Based on the control theory, the perturbation argument, and the matrix theory, the necessary and sufficient condition for MASs to reach mean-square consensus is derived in terms of stability of an array of low-dimensional matrices. Moreover, mean-square consensusable conditions with regard to network topology and agent dynamic structure are also provided. Finally, the effectiveness of the theoretical results is demonstrated through an illustrative example.

  14. Analysis of linear two-dimensional general rate model for chromatographic columns of cylindrical geometry.

    Science.gov (United States)

    Qamar, Shamsul; Uche, David U; Khan, Farman U; Seidel-Morgenstern, Andreas

    2017-05-05

    This work is concerned with the analytical solutions and moment analysis of a linear two-dimensional general rate model (2D-GRM) describing the transport of a solute through a chromatographic column of cylindrical geometry. Analytical solutions are derived through successive implementation of finite Hankel and Laplace transformations for two different sets of boundary conditions. The process is further analyzed by deriving analytical temporal moments from the Laplace domain solutions. Radial gradients are typically neglected in liquid chromatography studies which are particularly important in the case of non-perfect injections. Several test problems of single-solute transport are considered. The derived analytical results are validated against the numerical solutions of a high resolution finite volume scheme. The derived analytical results can play an important role in further development of liquid chromatography. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. Optimal Stochastic Control Problem for General Linear Dynamical Systems in Neuroscience

    Directory of Open Access Journals (Sweden)

    Yan Chen

    2017-01-01

    Full Text Available This paper considers a d-dimensional stochastic optimization problem in neuroscience. Suppose the arm’s movement trajectory is modeled by high-order linear stochastic differential dynamic system in d-dimensional space, the optimal trajectory, velocity, and variance are explicitly obtained by using stochastic control method, which allows us to analytically establish exact relationships between various quantities. Moreover, the optimal trajectory is almost a straight line for a reaching movement; the optimal velocity bell-shaped and the optimal variance are consistent with the experimental Fitts law; that is, the longer the time of a reaching movement, the higher the accuracy of arriving at the target position, and the results can be directly applied to designing a reaching movement performed by a robotic arm in a more general environment.

  16. A generalized linear factor model approach to the hierarchical framework for responses and response times.

    Science.gov (United States)

    Molenaar, Dylan; Tuerlinckx, Francis; van der Maas, Han L J

    2015-05-01

    We show how the hierarchical model for responses and response times as developed by van der Linden (2007), Fox, Klein Entink, and van der Linden (2007), Klein Entink, Fox, and van der Linden (2009), and Glas and van der Linden (2010) can be simplified to a generalized linear factor model with only the mild restriction that there is no hierarchical model at the item side. This result is valuable as it enables all well-developed modelling tools and extensions that come with these methods. We show that the restriction we impose on the hierarchical model does not influence parameter recovery under realistic circumstances. In addition, we present two illustrative real data analyses to demonstrate the practical benefits of our approach. © 2014 The British Psychological Society.

  17. An assessment of estimation methods for generalized linear mixed models with binary outcomes.

    Science.gov (United States)

    Capanu, Marinela; Gönen, Mithat; Begg, Colin B

    2013-11-20

    Two main classes of methodology have been developed for addressing the analytical intractability of generalized linear mixed models: likelihood-based methods and Bayesian methods. Likelihood-based methods such as the penalized quasi-likelihood approach have been shown to produce biased estimates especially for binary clustered data with small clusters sizes. More recent methods using adaptive Gaussian quadrature perform well but can be overwhelmed by problems with large numbers of random effects, and efficient algorithms to better handle these situations have not yet been integrated in standard statistical packages. Bayesian methods, although they have good frequentist properties when the model is correct, are known to be computationally intensive and also require specialized code, limiting their use in practice. In this article, we introduce a modification of the hybrid approach of Capanu and Begg, 2011, Biometrics 67, 371-380, as a bridge between the likelihood-based and Bayesian approaches by employing Bayesian estimation for the variance components followed by Laplacian estimation for the regression coefficients. We investigate its performance as well as that of several likelihood-based methods in the setting of generalized linear mixed models with binary outcomes. We apply the methods to three datasets and conduct simulations to illustrate their properties. Simulation results indicate that for moderate to large numbers of observations per random effect, adaptive Gaussian quadrature and the Laplacian approximation are very accurate, with adaptive Gaussian quadrature preferable as the number of observations per random effect increases. The hybrid approach is overall similar to the Laplace method, and it can be superior for data with very sparse random effects. Copyright © 2013 John Wiley & Sons, Ltd.

  18. An EM Algorithm for Double-Pareto-Lognormal Generalized Linear Model Applied to Heavy-Tailed Insurance Claims

    Directory of Open Access Journals (Sweden)

    Enrique Calderín-Ojeda

    2017-11-01

    Full Text Available Generalized linear models might not be appropriate when the probability of extreme events is higher than that implied by the normal distribution. Extending the method for estimating the parameters of a double Pareto lognormal distribution (DPLN in Reed and Jorgensen (2004, we develop an EM algorithm for the heavy-tailed Double-Pareto-lognormal generalized linear model. The DPLN distribution is obtained as a mixture of a lognormal distribution with a double Pareto distribution. In this paper the associated generalized linear model has the location parameter equal to a linear predictor which is used to model insurance claim amounts for various data sets. The performance is compared with those of the generalized beta (of the second kind and lognorma distributions.

  19. Poisson structure of the equations of ideal multispecies fluid electrodynamics

    International Nuclear Information System (INIS)

    Spencer, R.G.

    1984-01-01

    The equations of the two- (or multi-) fluid model of plasma physics are recast in Hamiltonian form, following general methods of symplectic geometry. The dynamical variables are the fields of physical interest, but are noncanonical, so that the Poisson bracket in the theory is not the standard one. However, it is a skew-symmetric bilinear form which, from the method of derivation, automatically satisfies the Jacobi identity; therefore, this noncanonical structure has all the essential properties of a canonical Poisson bracket

  20. Capturing Spike Variability in Noisy Izhikevich Neurons Using Point Process Generalized Linear Models.

    Science.gov (United States)

    Østergaard, Jacob; Kramer, Mark A; Eden, Uri T

    2018-01-01

    To understand neural activity, two broad categories of models exist: statistical and dynamical. While statistical models possess rigorous methods for parameter estimation and goodness-of-fit assessment, dynamical models provide mechanistic insight. In general, these two categories of models are separately applied; understanding the relationships between these modeling approaches remains an area of active research. In this letter, we examine this relationship using simulation. To do so, we first generate spike train data from a well-known dynamical model, the Izhikevich neuron, with a noisy input current. We then fit these spike train data with a statistical model (a generalized linear model, GLM, with multiplicative influences of past spiking). For different levels of noise, we show how the GLM captures both the deterministic features of the Izhikevich neuron and the variability driven by the noise. We conclude that the GLM captures essential features of the simulated spike trains, but for near-deterministic spike trains, goodness-of-fit analyses reveal that the model does not fit very well in a statistical sense; the essential random part of the GLM is not captured.

  1. Generalized Partially Linear Models for Incomplete Longitudinal Data In the Presence of Population-Level Information

    Science.gov (United States)

    Chen, Baojiang; Zhou, Xiao-Hua

    2013-01-01

    Summary In observational studies, interest often lies in estimation of the population-level relationship between the explanatory variables and dependent variables, and the estimation is often done using longitudinal data. Longitudinal data often feature sampling error and bias due to non-random drop-out. However, inclusion of population-level information can increase estimation efficiency. In this paper we consider a generalized partially linear model for incomplete longitudinal data in the presence of the population-level information. A pseudo-empirical likelihood-based method is introduced to incorporate population-level information, and non-random drop-out bias is corrected by using a weighted generalized estimating equations method. A three-step estimation procedure is proposed, which makes the computation easier. Several methods that are often used in practice are compared in simulation studies, which demonstrate that our proposed method can correct the non-random drop-out bias and increase the estimation efficiency, especially for small sample size or when the missing proportion is high. We apply this method to an Alzheimer's disease study. PMID:23413768

  2. Sparse generalized functional linear model for predicting remission status of depression patients.

    Science.gov (United States)

    Liu, Yashu; Nie, Zhi; Zhou, Jiayu; Farnum, Michael; Narayan, Vaibhav A; Wittenberg, Gayle; Ye, Jieping

    2014-01-01

    Complex diseases such as major depression affect people over time in complicated patterns. Longitudinal data analysis is thus crucial for understanding and prognosis of such diseases and has received considerable attention in the biomedical research community. Traditional classification and regression methods have been commonly applied in a simple (controlled) clinical setting with a small number of time points. However, these methods cannot be easily extended to the more general setting for longitudinal analysis, as they are not inherently built for time-dependent data. Functional regression, in contrast, is capable of identifying the relationship between features and outcomes along with time information by assuming features and/or outcomes as random functions over time rather than independent random variables. In this paper, we propose a novel sparse generalized functional linear model for the prediction of treatment remission status of the depression participants with longitudinal features. Compared to traditional functional regression models, our model enables high-dimensional learning, smoothness of functional coefficients, longitudinal feature selection and interpretable estimation of functional coefficients. Extensive experiments have been conducted on the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) data set and the results show that the proposed sparse functional regression method achieves significantly higher prediction power than existing approaches.

  3. Summary goodness-of-fit statistics for binary generalized linear models with noncanonical link functions.

    Science.gov (United States)

    Canary, Jana D; Blizzard, Leigh; Barry, Ronald P; Hosmer, David W; Quinn, Stephen J

    2016-05-01

    Generalized linear models (GLM) with a canonical logit link function are the primary modeling technique used to relate a binary outcome to predictor variables. However, noncanonical links can offer more flexibility, producing convenient analytical quantities (e.g., probit GLMs in toxicology) and desired measures of effect (e.g., relative risk from log GLMs). Many summary goodness-of-fit (GOF) statistics exist for logistic GLM. Their properties make the development of GOF statistics relatively straightforward, but it can be more difficult under noncanonical links. Although GOF tests for logistic GLM with continuous covariates (GLMCC) have been applied to GLMCCs with log links, we know of no GOF tests in the literature specifically developed for GLMCCs that can be applied regardless of link function chosen. We generalize the Tsiatis GOF statistic originally developed for logistic GLMCCs, (TG), so that it can be applied under any link function. Further, we show that the algebraically related Hosmer-Lemeshow (HL) and Pigeon-Heyse (J(2) ) statistics can be applied directly. In a simulation study, TG, HL, and J(2) were used to evaluate the fit of probit, log-log, complementary log-log, and log models, all calculated with a common grouping method. The TG statistic consistently maintained Type I error rates, while those of HL and J(2) were often lower than expected if terms with little influence were included. Generally, the statistics had similar power to detect an incorrect model. An exception occurred when a log GLMCC was incorrectly fit to data generated from a logistic GLMCC. In this case, TG had more power than HL or J(2) . © 2015 John Wiley & Sons Ltd/London School of Economics.

  4. The impact of covariate misclassification using generalized linear regression under covariate-adaptive randomization.

    Science.gov (United States)

    Fan, Liqiong; Yeatts, Sharon D; Wolf, Bethany J; McClure, Leslie A; Selim, Magdy; Palesch, Yuko Y

    2018-01-01

    Under covariate adaptive randomization, the covariate is tied to both randomization and analysis. Misclassification of such covariate will impact the intended treatment assignment; further, it is unclear what the appropriate analysis strategy should be. We explore the impact of such misclassification on the trial's statistical operating characteristics. Simulation scenarios were created based on the misclassification rate and the covariate effect on the outcome. Models including unadjusted, adjusted for the misclassified, or adjusted for the corrected covariate were compared using logistic regression for a binary outcome and Poisson regression for a count outcome. For the binary outcome using logistic regression, type I error can be maintained in the adjusted model, but the test is conservative using an unadjusted model. Power decreased with both increasing covariate effect on the outcome as well as the misclassification rate. Treatment effect estimates were biased towards the null for both the misclassified and unadjusted models. For the count outcome using a Poisson model, covariate misclassification led to inflated type I error probabilities and reduced power in the misclassified and the unadjusted model. The impact of covariate misclassification under covariate-adaptive randomization differs depending on the underlying distribution of the outcome.

  5. A generalized linear model for estimating spectrotemporal receptive fields from responses to natural sounds.

    Science.gov (United States)

    Calabrese, Ana; Schumacher, Joseph W; Schneider, David M; Paninski, Liam; Woolley, Sarah M N

    2011-01-11

    In the auditory system, the stimulus-response properties of single neurons are often described in terms of the spectrotemporal receptive field (STRF), a linear kernel relating the spectrogram of the sound stimulus to the instantaneous firing rate of the neuron. Several algorithms have been used to estimate STRFs from responses to natural stimuli; these algorithms differ in their functional models, cost functions, and regularization methods. Here, we characterize the stimulus-response function of auditory neurons using a generalized linear model (GLM). In this model, each cell's input is described by: 1) a stimulus filter (STRF); and 2) a post-spike filter, which captures dependencies on the neuron's spiking history. The output of the model is given by a series of spike trains rather than instantaneous firing rate, allowing the prediction of spike train responses to novel stimuli. We fit the model by maximum penalized likelihood to the spiking activity of zebra finch auditory midbrain neurons in response to conspecific vocalizations (songs) and modulation limited (ml) noise. We compare this model to normalized reverse correlation (NRC), the traditional method for STRF estimation, in terms of predictive power and the basic tuning properties of the estimated STRFs. We find that a GLM with a sparse prior predicts novel responses to both stimulus classes significantly better than NRC. Importantly, we find that STRFs from the two models derived from the same responses can differ substantially and that GLM STRFs are more consistent between stimulus classes than NRC STRFs. These results suggest that a GLM with a sparse prior provides a more accurate characterization of spectrotemporal tuning than does the NRC method when responses to complex sounds are studied in these neurons.

  6. Time-lapse joint AVO inversion using generalized linear method based on exact Zoeppritz equations

    Science.gov (United States)

    Zhi, Longxiao; Gu, Hanming

    2018-03-01

    The conventional method of time-lapse AVO (Amplitude Versus Offset) inversion is mainly based on the approximate expression of Zoeppritz equations. Though the approximate expression is concise and convenient to use, it has certain limitations. For example, its application condition is that the difference of elastic parameters between the upper medium and lower medium is little and the incident angle is small. In addition, the inversion of density is not stable. Therefore, we develop the method of time-lapse joint AVO inversion based on exact Zoeppritz equations. In this method, we apply exact Zoeppritz equations to calculate the reflection coefficient of PP wave. And in the construction of objective function for inversion, we use Taylor series expansion to linearize the inversion problem. Through the joint AVO inversion of seismic data in baseline survey and monitor survey, we can obtain the P-wave velocity, S-wave velocity, density in baseline survey and their time-lapse changes simultaneously. We can also estimate the oil saturation change according to inversion results. Compared with the time-lapse difference inversion, the joint inversion doesn't need certain assumptions and can estimate more parameters simultaneously. It has a better applicability. Meanwhile, by using the generalized linear method, the inversion is easily implemented and its calculation cost is small. We use the theoretical model to generate synthetic seismic records to test and analyze the influence of random noise. The results can prove the availability and anti-noise-interference ability of our method. We also apply the inversion to actual field data and prove the feasibility of our method in actual situation.

  7. Efficient Levenberg-Marquardt minimization of the maximum likelihood estimator for Poisson deviates

    Energy Technology Data Exchange (ETDEWEB)

    Laurence, T; Chromy, B

    2009-11-10

    ) for the Poisson distribution is also well known, but has not become generally used. This is primarily because, in contrast to non-linear least squares fitting, there has been no quick, robust, and general fitting method. In the field of fluorescence lifetime spectroscopy and imaging, there have been some efforts to use this estimator through minimization routines such as Nelder-Mead optimization, exhaustive line searches, and Gauss-Newton minimization. Minimization based on specific one- or multi-exponential models has been used to obtain quick results, but this procedure does not allow the incorporation of the instrument response, and is not generally applicable to models found in other fields. Methods for using the MLE for Poisson-distributed data have been published by the wider spectroscopic community, including iterative minimization schemes based on Gauss-Newton minimization. The slow acceptance of these procedures for fitting event counting histograms may also be explained by the use of the ubiquitous, fast Levenberg-Marquardt (L-M) fitting procedure for fitting non-linear models using least squares fitting (simple searches obtain {approx}10000 references - this doesn't include those who use it, but don't know they are using it). The benefits of L-M include a seamless transition between Gauss-Newton minimization and downward gradient minimization through the use of a regularization parameter. This transition is desirable because Gauss-Newton methods converge quickly, but only within a limited domain of convergence; on the other hand the downward gradient methods have a much wider domain of convergence, but converge extremely slowly nearer the minimum. L-M has the advantages of both procedures: relative insensitivity to initial parameters and rapid convergence. Scientists, when wanting an answer quickly, will fit data using L-M, get an answer, and move on. Only those that are aware of the bias issues will bother to fit using the more appropriate MLE

  8. A multiresolution method for solving the Poisson equation using high order regularization

    DEFF Research Database (Denmark)

    Hejlesen, Mads Mølholm; Walther, Jens Honore

    2016-01-01

    and regularized Green's functions corresponding to the difference in the spatial resolution between the patches. The full solution is obtained utilizing the linearity of the Poisson equation enabling super-position of solutions. We show that the multiresolution Poisson solver produces convergence rates......We present a novel high order multiresolution Poisson solver based on regularized Green's function solutions to obtain exact free-space boundary conditions while using fast Fourier transforms for computational efficiency. Multiresolution is a achieved through local refinement patches...

  9. A generalized linear-quadratic model incorporating reciprocal time pattern of radiation damage repair

    International Nuclear Information System (INIS)

    Huang, Zhibin; Mayr, Nina A.; Lo, Simon S.; Wang, Jian Z.; Jia Guang; Yuh, William T. C.; Johnke, Roberta

    2012-01-01

    Purpose: It has been conventionally assumed that the repair rate for sublethal damage (SLD) remains constant during the entire radiation course. However, increasing evidence from animal studies suggest that this may not the case. Rather, it appears that the repair rate for radiation-induced SLD slows down with increasing time. Such a slowdown in repair would suggest that the exponential repair pattern would not necessarily accurately predict repair process. As a result, the purpose of this study was to investigate a new generalized linear-quadratic (LQ) model incorporating a repair pattern with reciprocal time. The new formulas were tested with published experimental data. Methods: The LQ model has been widely used in radiation therapy, and the parameter G in the surviving fraction represents the repair process of sublethal damage with T r as the repair half-time. When a reciprocal pattern of repair process was adopted, a closed form of G was derived analytically for arbitrary radiation schemes. The published animal data adopted to test the reciprocal formulas. Results: A generalized LQ model to describe the repair process in a reciprocal pattern was obtained. Subsequently, formulas for special cases were derived from this general form. The reciprocal model showed a better fit to the animal data than the exponential model, particularly for the ED50 data (reduced χ 2 min of 2.0 vs 4.3, p = 0.11 vs 0.006), with the following gLQ parameters: α/β = 2.6-4.8 Gy, T r = 3.2-3.9 h for rat feet skin, and α/β = 0.9 Gy, T r = 1.1 h for rat spinal cord. Conclusions: These results of repair process following a reciprocal time suggest that the generalized LQ model incorporating the reciprocal time of sublethal damage repair shows a better fit than the exponential repair model. These formulas can be used to analyze the experimental and clinical data, where a slowing-down repair process appears during the course of radiation therapy.

  10. A generalized linear-quadratic model incorporating reciprocal time pattern of radiation damage repair.

    Science.gov (United States)

    Huang, Zhibin; Mayr, Nina A; Lo, Simon S; Wang, Jian Z; Jia, Guang; Yuh, William T C; Johnke, Roberta

    2012-01-01

    It has been conventionally assumed that the repair rate for sublethal damage (SLD) remains constant during the entire radiation course. However, increasing evidence from animal studies suggest that this may not the case. Rather, it appears that the repair rate for radiation-induced SLD slows down with increasing time. Such a slowdown in repair would suggest that the exponential repair pattern would not necessarily accurately predict repair process. As a result, the purpose of this study was to investigate a new generalized linear-quadratic (LQ) model incorporating a repair pattern with reciprocal time. The new formulas were tested with published experimental data. The LQ model has been widely used in radiation therapy, and the parameter G in the surviving fraction represents the repair process of sublethal damage with T(r) as the repair half-time. When a reciprocal pattern of repair process was adopted, a closed form of G was derived analytically for arbitrary radiation schemes. The published animal data adopted to test the reciprocal formulas. A generalized LQ model to describe the repair process in a reciprocal pattern was obtained. Subsequently, formulas for special cases were derived from this general form. The reciprocal model showed a better fit to the animal data than the exponential model, particularly for the ED50 data (reduced χ(2) (min) of 2.0 vs 4.3, p = 0.11 vs 0.006), with the following gLQ parameters: α/β = 2.6-4.8 Gy, T(r) = 3.2-3.9 h for rat feet skin, and α/β = 0.9 Gy, T(r) = 1.1 h for rat spinal cord. These results of repair process following a reciprocal time suggest that the generalized LQ model incorporating the reciprocal time of sublethal damage repair shows a better fit than the exponential repair model. These formulas can be used to analyze the experimental and clinical data, where a slowing-down repair process appears during the course of radiation therapy.

  11. Using Generalized Linear Mixed Models to Evaluate Inconsistency within a Network Meta-Analysis.

    Science.gov (United States)

    Tu, Yu-Kang

    2015-12-01

    Network meta-analysis compares multiple treatments by incorporating direct and indirect evidence into a general statistical framework. One issue with the validity of network meta-analysis is inconsistency between direct and indirect evidence within a loop formed by three treatments. Recently, the inconsistency issue has been explored further and a complex design-by-treatment interaction model proposed. The aim of this article was to show how to evaluate the design-by-treatment interaction model using the generalized linear mixed model. We proposed an arm-based approach to evaluating the design-by-treatment inconsistency, which is flexible in modeling different types of outcome variables. We used the smoking cessation data to compare results from our arm-based approach with those from the standard contrast-based approach. Because the contrast-based approach requires transformation of data, our example showed that such a transformation may yield biases in the treatment effect and inconsistency evaluation, when event rates were low in some treatments. We also compared contrast-based and arm-based models in the evaluation of design inconsistency when different heterogeneity variances were estimated, and the arm-based model yielded more accurate results. Because some statistical software commands can detect the collinearity among variables and automatically remove the redundant ones, we can use this advantage to help with placing the inconsistency parameters. This could be very useful for a network meta-analysis involving many designs and treatments. Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  12. Generalized Jeans' Escape of Pick-Up Ions in Quasi-Linear Relaxation

    Science.gov (United States)

    Moore, T. E.; Khazanov, G. V.

    2011-01-01

    Jeans escape is a well-validated formulation of upper atmospheric escape that we have generalized to estimate plasma escape from ionospheres. It involves the computation of the parts of particle velocity space that are unbound by the gravitational potential at the exobase, followed by a calculation of the flux carried by such unbound particles as they escape from the potential well. To generalize this approach for ions, we superposed an electrostatic ambipolar potential and a centrifugal potential, for motions across and along a divergent magnetic field. We then considered how the presence of superthermal electrons, produced by precipitating auroral primary electrons, controls the ambipolar potential. We also showed that the centrifugal potential plays a small role in controlling the mass escape flux from the terrestrial ionosphere. We then applied the transverse ion velocity distribution produced when ions, picked up by supersonic (i.e., auroral) ionospheric convection, relax via quasi-linear diffusion, as estimated for cometary comas [1]. The results provide a theoretical basis for observed ion escape response to electromagnetic and kinetic energy sources. They also suggest that super-sonic but sub-Alfvenic flow, with ion pick-up, is a unique and important regime of ion-neutral coupling, in which plasma wave-particle interactions are driven by ion-neutral collisions at densities for which the collision frequency falls near or below the gyro-frequency. As another possible illustration of this process, the heliopause ribbon discovered by the IBEX mission involves interactions between the solar wind ions and the interstellar neutral gas, in a regime that may be analogous [2].

  13. The overlooked potential of Generalized Linear Models in astronomy-II: Gamma regression and photometric redshifts

    Science.gov (United States)

    Elliott, J.; de Souza, R. S.; Krone-Martins, A.; Cameron, E.; Ishida, E. E. O.; Hilbe, J.

    2015-04-01

    Machine learning techniques offer a precious tool box for use within astronomy to solve problems involving so-called big data. They provide a means to make accurate predictions about a particular system without prior knowledge of the underlying physical processes of the data. In this article, and the companion papers of this series, we present the set of Generalized Linear Models (GLMs) as a fast alternative method for tackling general astronomical problems, including the ones related to the machine learning paradigm. To demonstrate the applicability of GLMs to inherently positive and continuous physical observables, we explore their use in estimating the photometric redshifts of galaxies from their multi-wavelength photometry. Using the gamma family with a log link function we predict redshifts from the PHoto-z Accuracy Testing simulated catalogue and a subset of the Sloan Digital Sky Survey from Data Release 10. We obtain fits that result in catastrophic outlier rates as low as ∼1% for simulated and ∼2% for real data. Moreover, we can easily obtain such levels of precision within a matter of seconds on a normal desktop computer and with training sets that contain merely thousands of galaxies. Our software is made publicly available as a user-friendly package developed in Python, R and via an interactive web application. This software allows users to apply a set of GLMs to their own photometric catalogues and generates publication quality plots with minimum effort. By facilitating their ease of use to the astronomical community, this paper series aims to make GLMs widely known and to encourage their implementation in future large-scale projects, such as the Large Synoptic Survey Telescope.

  14. Graded geometry and Poisson reduction

    OpenAIRE

    Cattaneo, A S; Zambon, M

    2009-01-01

    The main result of [2] extends the Marsden-Ratiu reduction theorem [4] in Poisson geometry, and is proven by means of graded geometry. In this note we provide the background material about graded geometry necessary for the proof in [2]. Further, we provide an alternative algebraic proof for the main result. ©2009 American Institute of Physics

  15. Quantifying the interactions among metal mixtures in toxicodynamic process with generalized linear model.

    Science.gov (United States)

    Feng, Jianfeng; Gao, Yongfei; Ji, Yijun; Zhu, Lin

    2018-03-05

    Predicting the toxicity of chemical mixtures is difficult because of the additive, antagonistic, or synergistic interactions among the mixture components. Antagonistic and synergistic interactions are dominant in metal mixtures, and their distributions may correlate with exposure concentrations. However, whether the interaction types of metal mixtures change at different time points during toxicodynamic (TD) processes is undetermined because of insufficient appropriate models and metal bioaccumulation data at different time points. In the present study, the generalized linear model (GLM) was used to illustrate the combined toxicities of binary metal mixtures, such as Cu-Zn, Cu-Cd, and Cd-Pb, to zebrafish larvae (Danio rerio). GLM was also used to identify possible interaction types among these method for the traditional concentration addition (CA) and independent action (IA) models. Then the GLM were applied to quantify the different possible interaction types for metal mixture toxicity (Cu-Zn, Cu-Cd, and Cd-Pb to D. rerio and Ni-Co to Oligochaeta Enchytraeus crypticus) during the TD process at different exposure times. We found different metal interaction responses in the TD process and interactive coefficients significantly changed at different exposure times (pmixture toxicology on organisms. Moreover, care should be taken when evaluating interactions in toxicity prediction because results may vary at different time points. The GLM could be an alternative or complementary approach for BLM to analyze and predict metal mixture toxicity. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Spatial generalized linear mixed models of electric power outages due to hurricanes and ice storms

    International Nuclear Information System (INIS)

    Liu Haibin; Davidson, Rachel A.; Apanasovich, Tatiyana V.

    2008-01-01

    This paper presents new statistical models that predict the number of hurricane- and ice storm-related electric power outages likely to occur in each 3 kmx3 km grid cell in a region. The models are based on a large database of recent outages experienced by three major East Coast power companies in six hurricanes and eight ice storms. A spatial generalized linear mixed modeling (GLMM) approach was used in which spatial correlation is incorporated through random effects. Models were fitted using a composite likelihood approach and the covariance matrix was estimated empirically. A simulation study was conducted to test the model estimation procedure, and model training, validation, and testing were done to select the best models and assess their predictive power. The final hurricane model includes number of protective devices, maximum gust wind speed, hurricane indicator, and company indicator covariates. The final ice storm model includes number of protective devices, ice thickness, and ice storm indicator covariates. The models should be useful for power companies as they plan for future storms. The statistical modeling approach offers a new way to assess the reliability of electric power and other infrastructure systems in extreme events

  17. Generalized linear discriminant analysis: a unified framework and efficient model selection.

    Science.gov (United States)

    Ji, Shuiwang; Ye, Jieping

    2008-10-01

    High-dimensional data are common in many domains, and dimensionality reduction is the key to cope with the curse-of-dimensionality. Linear discriminant analysis (LDA) is a well-known method for supervised dimensionality reduction. When dealing with high-dimensional and low sample size data, classical LDA suffers from the singularity problem. Over the years, many algorithms have been developed to overcome this problem, and they have been applied successfully in various applications. However, there is a lack of a systematic study of the commonalities and differences of these algorithms, as well as their intrinsic relationships. In this paper, a unified framework for generalized LDA is proposed, which elucidates the properties of various algorithms and their relationships. Based on the proposed framework, we show that the matrix computations involved in LDA-based algorithms can be simplified so that the cross-validation procedure for model selection can be performed efficiently. We conduct extensive experiments using a collection of high-dimensional data sets, including text documents, face images, gene expression data, and gene expression pattern images, to evaluate the proposed theories and algorithms.

  18. Determination of a Differential Item Functioning Procedure Using the Hierarchical Generalized Linear Model

    Directory of Open Access Journals (Sweden)

    Tülin Acar

    2012-01-01

    Full Text Available The aim of this research is to compare the result of the differential item functioning (DIF determining with hierarchical generalized linear model (HGLM technique and the results of the DIF determining with logistic regression (LR and item response theory–likelihood ratio (IRT-LR techniques on the test items. For this reason, first in this research, it is determined whether the students encounter DIF with HGLM, LR, and IRT-LR techniques according to socioeconomic status (SES, in the Turkish, Social Sciences, and Science subtest items of the Secondary School Institutions Examination. When inspecting the correlations among the techniques in terms of determining the items having DIF, it was discovered that there was significant correlation between the results of IRT-LR and LR techniques in all subtests; merely in Science subtest, the results of the correlation between HGLM and IRT-LR techniques were found significant. DIF applications can be made on test items with other DIF analysis techniques that were not taken to the scope of this research. The analysis results, which were determined by using the DIF techniques in different sample sizes, can be compared.

  19. An efficient hierarchical generalized linear mixed model for mapping QTL of ordinal traits in crop cultivars.

    Science.gov (United States)

    Feng, Jian-Ying; Zhang, Jin; Zhang, Wen-Jie; Wang, Shi-Bo; Han, Shi-Feng; Zhang, Yuan-Ming

    2013-01-01

    Many important phenotypic traits in plants are ordinal. However, relatively little is known about the methodologies for ordinal trait association studies. In this study, we proposed a hierarchical generalized linear mixed model for mapping quantitative trait locus (QTL) of ordinal traits in crop cultivars. In this model, all the main-effect QTL and QTL-by-environment interaction were treated as random, while population mean, environmental effect and population structure were fixed. In the estimation of parameters, the pseudo data normal approximation of likelihood function and empirical Bayes approach were adopted. A series of Monte Carlo simulation experiments were performed to confirm the reliability of new method. The result showed that new method works well with satisfactory statistical power and precision. The new method was also adopted to dissect the genetic basis of soybean alkaline-salt tolerance in 257 soybean cultivars obtained, by stratified random sampling, from 6 geographic ecotypes in China. As a result, 6 main-effect QTL and 3 QTL-by-environment interactions were identified.

  20. Profile local linear estimation of generalized semiparametric regression model for longitudinal data.

    Science.gov (United States)

    Sun, Yanqing; Sun, Liuquan; Zhou, Jie

    2013-07-01

    This paper studies the generalized semiparametric regression model for longitudinal data where the covariate effects are constant for some and time-varying for others. Different link functions can be used to allow more flexible modelling of longitudinal data. The nonparametric components of the model are estimated using a local linear estimating equation and the parametric components are estimated through a profile estimating function. The method automatically adjusts for heterogeneity of sampling times, allowing the sampling strategy to depend on the past sampling history as well as possibly time-dependent covariates without specifically model such dependence. A [Formula: see text]-fold cross-validation bandwidth selection is proposed as a working tool for locating an appropriate bandwidth. A criteria for selecting the link function is proposed to provide better fit of the data. Large sample properties of the proposed estimators are investigated. Large sample pointwise and simultaneous confidence intervals for the regression coefficients are constructed. Formal hypothesis testing procedures are proposed to check for the covariate effects and whether the effects are time-varying. A simulation study is conducted to examine the finite sample performances of the proposed estimation and hypothesis testing procedures. The methods are illustrated with a data example.

  1. Mitigating Bias in Generalized Linear Mixed Models: The Case for Bayesian Nonparametrics.

    Science.gov (United States)

    Antonelli, Joseph; Trippa, Lorenzo; Haneuse, Sebastien

    2016-02-01

    Generalized linear mixed models are a common statistical tool for the analysis of clustered or longitudinal data where correlation is accounted for through cluster-specific random effects. In practice, the distribution of the random effects is typically taken to be a Normal distribution, although if this does not hold then the model is misspecified and standard estimation/inference may be invalid. An alternative is to perform a so-called nonparametric Bayesian analyses in which one assigns a Dirichlet process (DP) prior to the unknown distribution of the random effects. In this paper we examine operating characteristics for estimation of fixed effects and random effects based on such an analysis under a range of "true" random effects distributions. As part of this we investigate various approaches for selection of the precision parameter of the DP prior. In addition, we illustrate the use of the methods with an analysis of post-operative complications among n = 18, 643 female Medicare beneficiaries who underwent a hysterectomy procedure at N = 503 hospitals in the US. Overall, we conclude that using the DP priori n modeling the random effect distribution results in large reductions of bias with little loss of efficiency. While no single choice for the precision parameter will be optimal in all settings, certain strategies such as importance sampling or empirical Bayes can be used to obtain reasonable results in a broad range of data scenarios.

  2. Fast inference in generalized linear models via expected log-likelihoods

    Science.gov (United States)

    Ramirez, Alexandro D.; Paninski, Liam

    2015-01-01

    Generalized linear models play an essential role in a wide variety of statistical applications. This paper discusses an approximation of the likelihood in these models that can greatly facilitate computation. The basic idea is to replace a sum that appears in the exact log-likelihood by an expectation over the model covariates; the resulting “expected log-likelihood” can in many cases be computed significantly faster than the exact log-likelihood. In many neuroscience experiments the distribution over model covariates is controlled by the experimenter and the expected log-likelihood approximation becomes particularly useful; for example, estimators based on maximizing this expected log-likelihood (or a penalized version thereof) can often be obtained with orders of magnitude computational savings compared to the exact maximum likelihood estimators. A risk analysis establishes that these maximum EL estimators often come with little cost in accuracy (and in some cases even improved accuracy) compared to standard maximum likelihood estimates. Finally, we find that these methods can significantly decrease the computation time of marginal likelihood calculations for model selection and of Markov chain Monte Carlo methods for sampling from the posterior parameter distribution. We illustrate our results by applying these methods to a computationally-challenging dataset of neural spike trains obtained via large-scale multi-electrode recordings in the primate retina. PMID:23832289

  3. Bivariate Random Effects Meta-analysis of Diagnostic Studies Using Generalized Linear Mixed Models

    Science.gov (United States)

    GUO, HONGFEI; ZHOU, YIJIE

    2011-01-01

    Bivariate random effect models are currently one of the main methods recommended to synthesize diagnostic test accuracy studies. However, only the logit-transformation on sensitivity and specificity has been previously considered in the literature. In this paper, we consider a bivariate generalized linear mixed model to jointly model the sensitivities and specificities, and discuss the estimation of the summary receiver operating characteristic curve (ROC) and the area under the ROC curve (AUC). As the special cases of this model, we discuss the commonly used logit, probit and complementary log-log transformations. To evaluate the impact of misspecification of the link functions on the estimation, we present two case studies and a set of simulation studies. Our study suggests that point estimation of the median sensitivity and specificity, and AUC is relatively robust to the misspecification of the link functions. However, the misspecification of link functions has a noticeable impact on the standard error estimation and the 95% confidence interval coverage, which emphasizes the importance of choosing an appropriate link function to make statistical inference. PMID:19959794

  4. Fish biological effect monitoring of chemical stressors using a generalized linear model in South Sea, Korea.

    Science.gov (United States)

    Jung, Jee-Hyun; Choi, Seung Bae; Hong, Sang Hee; Chae, Young Sun; Kim, Ha Na; Yim, Un Hyuk; Ha, Sung Yong; Han, Gi Myung; Kim, Dae Jung; Shim, Won Joon

    2014-01-15

    To evaluate the health status at six different study areas, we used the generalized linear model approach with selected biochemical markers in resident fish from uncontaminated and contaminated sites. We also confirmed the independence between the biochemical indices and the morphometric indices including the hepato-somatic index (HSI), gonado-somatic index (GSI), and condition factor (CF) in fish from the sampling areas. The effect of area on the presence of biotransformation markers (ethoxyresorufin-O-deethylase activity; EROD) was significantly high in Masan Bay. The area with the greatest effect on acetylcholinesterase (AChE) activity was Jindong Bay, while there was no significant effect of GSI, HSI, CF, and sex in the EROD model and HSI, CF and sex in the AChE model. These results clarify that fish from Masan, Gwangyang and Jindong Bay were affected by pollutant stress, and the analysis of sensitive biochemical responses allowed for an improved interpretation of the results. Copyright © 2013 Elsevier Ltd. All rights reserved.

  5. Establishment of a new initial dose plan for vancomycin using the generalized linear mixed model.

    Science.gov (United States)

    Kourogi, Yasuyuki; Ogata, Kenji; Takamura, Norito; Tokunaga, Jin; Setoguchi, Nao; Kai, Mitsuhiro; Tanaka, Emi; Chiyotanda, Susumu

    2017-04-08

    When administering vancomycin hydrochloride (VCM), the initial dose is adjusted to ensure that the steady-state trough value (Css-trough) remains within the effective concentration range. However, the Css-trough (population mean method predicted value [PMMPV]) calculated using the population mean method (PMM) often deviate from the effective concentration range. In this study, we used the generalized linear mixed model (GLMM) for initial dose planning to create a model that accurately predicts Css-trough, and subsequently assessed its prediction accuracy. The study included 46 subjects whose trough values were measured after receiving VCM. We calculated the Css-trough (Bayesian estimate predicted value [BEPV]) from the Bayesian estimates of trough values. Using the patients' medical data, we created models that predict the BEPV and selected the model with minimum information criterion (GLMM best model). We then calculated the Css-trough (GLMMPV) from the GLMM best model and compared the BEPV correlation with GLMMPV and with PMMPV. The GLMM best model was {[0.977 + (males: 0.029 or females: -0.081)] × PMMPV + 0.101 × BUN/adjusted SCr - 12.899 × SCr adjusted amount}. The coefficients of determination for BEPV/GLMMPV and BEPV/PMMPV were 0.623 and 0.513, respectively. We demonstrated that the GLMM best model was more accurate in predicting the Css-trough than the PMM.

  6. Multivariate linear regression analysis to identify general factors for quantitative predictions of implant stability quotient values.

    Directory of Open Access Journals (Sweden)

    Hairong Huang

    Full Text Available This study identified potential general influencing factors for a mathematical prediction of implant stability quotient (ISQ values in clinical practice.We collected the ISQ values of 557 implants from 2 different brands (SICace and Osstem placed by 2 surgeons in 336 patients. Surgeon 1 placed 329 SICace implants, and surgeon 2 placed 113 SICace implants and 115 Osstem implants. ISQ measurements were taken at T1 (immediately after implant placement and T2 (before dental restoration. A multivariate linear regression model was used to analyze the influence of the following 11 candidate factors for stability prediction: sex, age, maxillary/mandibular location, bone type, immediate/delayed implantation, bone grafting, insertion torque, I-stage or II-stage healing pattern, implant diameter, implant length and T1-T2 time interval.The need for bone grafting as a predictor significantly influenced ISQ values in all three groups at T1 (weight coefficients ranging from -4 to -5. In contrast, implant diameter consistently influenced the ISQ values in all three groups at T2 (weight coefficients ranging from 3.4 to 4.2. Other factors, such as sex, age, I/II-stage implantation and bone type, did not significantly influence ISQ values at T2, and implant length did not significantly influence ISQ values at T1 or T2.These findings provide a rational basis for mathematical models to quantitatively predict the ISQ values of implants in clinical practice.

  7. Setting a generalized functional linear model (GFLM for the classification of different types of cancer

    Directory of Open Access Journals (Sweden)

    Miguel Flores

    2016-11-01

    Full Text Available This work aims to classify the DNA sequences of healthy and malignant cancer respectively. For this, supervised and unsupervised classification methods from a functional context are used; i.e. each strand of DNA is an observation. The observations are discretized, for that reason different ways to represent these observations with functions are evaluated. In addition, an exploratory study is done: estimating the mean and variance of each functional type of cancer. For the unsupervised classification method, hierarchical clustering with different measures of functional distance is used. On the other hand, for the supervised classification method, a functional generalized linear model is used. For this model the first and second derivatives are used which are included as discriminating variables. It has been verified that one of the advantages of working in the functional context is to obtain a model to correctly classify cancers by 100%. For the implementation of the methods it has been used the fda.usc R package that includes all the techniques of functional data analysis used in this work. In addition, some that have been developed in recent decades. For more details of these techniques can be consulted Ramsay, J. O. and Silverman (2005 and Ferraty et al. (2006.

  8. A generalization of the Becker model in linear viscoelasticity: creep, relaxation and internal friction

    Science.gov (United States)

    Mainardi, Francesco; Masina, Enrico; Spada, Giorgio

    2018-02-01

    We present a new rheological model depending on a real parameter ν \\in [0,1], which reduces to the Maxwell body for ν =0 and to the Becker body for ν =1. The corresponding creep law is expressed in an integral form in which the exponential function of the Becker model is replaced and generalized by a Mittag-Leffler function of order ν . Then the corresponding non-dimensional creep function and its rate are studied as functions of time for different values of ν in order to visualize the transition from the classical Maxwell body to the Becker body. Based on the hereditary theory of linear viscoelasticity, we also approximate the relaxation function by solving numerically a Volterra integral equation of the second kind. In turn, the relaxation function is shown versus time for different values of ν to visualize again the transition from the classical Maxwell body to the Becker body. Furthermore, we provide a full characterization of the new model by computing, in addition to the creep and relaxation functions, the so-called specific dissipation Q^{-1} as a function of frequency, which is of particular relevance for geophysical applications.

  9. Predicting oropharyngeal tumor volume throughout the course of radiation therapy from pretreatment computed tomography data using general linear models

    International Nuclear Information System (INIS)

    Yock, Adam D.; Kudchadker, Rajat J.; Rao, Arvind; Dong, Lei; Beadle, Beth M.; Garden, Adam S.; Court, Laurence E.

    2014-01-01

    Purpose: The purpose of this work was to develop and evaluate the accuracy of several predictive models of variation in tumor volume throughout the course of radiation therapy. Methods: Nineteen patients with oropharyngeal cancers were imaged daily with CT-on-rails for image-guided alignment per an institutional protocol. The daily volumes of 35 tumors in these 19 patients were determined and used to generate (1) a linear model in which tumor volume changed at a constant rate, (2) a general linear model that utilized the power fit relationship between the daily and initial tumor volumes, and (3) a functional general linear model that identified and exploited the primary modes of variation between time series describing the changing tumor volumes. Primary and nodal tumor volumes were examined separately. The accuracy of these models in predicting daily tumor volumes were compared with those of static and linear reference models using leave-one-out cross-validation. Results: In predicting the daily volume of primary tumors, the general linear model and the functional general linear model were more accurate than the static reference model by 9.9% (range: −11.6%–23.8%) and 14.6% (range: −7.3%–27.5%), respectively, and were more accurate than the linear reference model by 14.2% (range: −6.8%–40.3%) and 13.1% (range: −1.5%–52.5%), respectively. In predicting the daily volume of nodal tumors, only the 14.4% (range: −11.1%–20.5%) improvement in accuracy of the functional general linear model compared to the static reference model was statistically significant. Conclusions: A general linear model and a functional general linear model trained on data from a small population of patients can predict the primary tumor volume throughout the course of radiation therapy with greater accuracy than standard reference models. These more accurate models may increase the prognostic value of information about the tumor garnered from pretreatment computed tomography

  10. Estimating organ doses from tube current modulated CT examinations using a generalized linear model.

    Science.gov (United States)

    Bostani, Maryam; McMillan, Kyle; Lu, Peiyun; Kim, Grace Hyun J; Cody, Dianna; Arbique, Gary; Greenberg, S Bruce; DeMarco, John J; Cagnon, Chris H; McNitt-Gray, Michael F

    2017-04-01

    Currently, available Computed Tomography dose metrics are mostly based on fixed tube current Monte Carlo (MC) simulations and/or physical measurements such as the size specific dose estimate (SSDE). In addition to not being able to account for Tube Current Modulation (TCM), these dose metrics do not represent actual patient dose. The purpose of this study was to generate and evaluate a dose estimation model based on the Generalized Linear Model (GLM), which extends the ability to estimate organ dose from tube current modulated examinations by incorporating regional descriptors of patient size, scanner output, and other scan-specific variables as needed. The collection of a total of 332 patient CT scans at four different institutions was approved by each institution's IRB and used to generate and test organ dose estimation models. The patient population consisted of pediatric and adult patients and included thoracic and abdomen/pelvis scans. The scans were performed on three different CT scanner systems. Manual segmentation of organs, depending on the examined anatomy, was performed on each patient's image series. In addition to the collected images, detailed TCM data were collected for all patients scanned on Siemens CT scanners, while for all GE and Toshiba patients, data representing z-axis-only TCM, extracted from the DICOM header of the images, were used for TCM simulations. A validated MC dosimetry package was used to perform detailed simulation of CT examinations on all 332 patient models to estimate dose to each segmented organ (lungs, breasts, liver, spleen, and kidneys), denoted as reference organ dose values. Approximately 60% of the data were used to train a dose estimation model, while the remaining 40% was used to evaluate performance. Two different methodologies were explored using GLM to generate a dose estimation model: (a) using the conventional exponential relationship between normalized organ dose and size with regional water equivalent diameter

  11. Deriving robust and globalized robust solutions of uncertain linear programs having general convex uncertainty sets

    NARCIS (Netherlands)

    Gorissen, B.L.; Blanc, J.P.C.; den Hertog, D.; Ben-Tal, A.

    We propose a new way to derive tractable robust counterparts of a linear program based on the duality between the robust (“pessimistic”) primal problem and its “optimistic” dual. First we obtain a new convex reformulation of the dual problem of a robust linear program, and then show how to construct

  12. Generalized linear mixed models can detect unimodal species-environment relationships

    NARCIS (Netherlands)

    Jamil, Tahira; Braak, ter C.J.F.

    2013-01-01

    Niche theory predicts that species occurrence and abundance show non-linear, unimodal relationships with respect to environmental gradients. Unimodal models, such as the Gaussian (logistic) model, are however more difficult to fit to data than linear ones, particularly in a multi-species context in

  13. Accounting for misclassification in electronic health records-derived exposures using generalized linear finite mixture models.

    Science.gov (United States)

    Hubbard, Rebecca A; Johnson, Eric; Chubak, Jessica; Wernli, Karen J; Kamineni, Aruna; Bogart, Andy; Rutter, Carolyn M

    2017-06-01

    Exposures derived from electronic health records (EHR) may be misclassified, leading to biased estimates of their association with outcomes of interest. An example of this problem arises in the context of cancer screening where test indication, the purpose for which a test was performed, is often unavailable. This poses a challenge to understanding the effectiveness of screening tests because estimates of screening test effectiveness are biased if some diagnostic tests are misclassified as screening. Prediction models have been developed for a variety of exposure variables that can be derived from EHR, but no previous research has investigated appropriate methods for obtaining unbiased association estimates using these predicted probabilities. The full likelihood incorporating information on both the predicted probability of exposure-class membership and the association between the exposure and outcome of interest can be expressed using a finite mixture model. When the regression model of interest is a generalized linear model (GLM), the expectation-maximization algorithm can be used to estimate the parameters using standard software for GLMs. Using simulation studies, we compared the bias and efficiency of this mixture model approach to alternative approaches including multiple imputation and dichotomization of the predicted probabilities to create a proxy for the missing predictor. The mixture model was the only approach that was unbiased across all scenarios investigated. Finally, we explored the performance of these alternatives in a study of colorectal cancer screening with colonoscopy. These findings have broad applicability in studies using EHR data where gold-standard exposures are unavailable and prediction models have been developed for estimating proxies.

  14. Protein structure validation by generalized linear model root-mean-square deviation prediction.

    Science.gov (United States)

    Bagaria, Anurag; Jaravine, Victor; Huang, Yuanpeng J; Montelione, Gaetano T; Güntert, Peter

    2012-02-01

    Large-scale initiatives for obtaining spatial protein structures by experimental or computational means have accentuated the need for the critical assessment of protein structure determination and prediction methods. These include blind test projects such as the critical assessment of protein structure prediction (CASP) and the critical assessment of protein structure determination by nuclear magnetic resonance (CASD-NMR). An important aim is to establish structure validation criteria that can reliably assess the accuracy of a new protein structure. Various quality measures derived from the coordinates have been proposed. A universal structural quality assessment method should combine multiple individual scores in a meaningful way, which is challenging because of their different measurement units. Here, we present a method based on a generalized linear model (GLM) that combines diverse protein structure quality scores into a single quantity with intuitive meaning, namely the predicted coordinate root-mean-square deviation (RMSD) value between the present structure and the (unavailable) "true" structure (GLM-RMSD). For two sets of structural models from the CASD-NMR and CASP projects, this GLM-RMSD value was compared with the actual accuracy given by the RMSD value to the corresponding, experimentally determined reference structure from the Protein Data Bank (PDB). The correlation coefficients between actual (model vs. reference from PDB) and predicted (model vs. "true") heavy-atom RMSDs were 0.69 and 0.76, for the two datasets from CASD-NMR and CASP, respectively, which is considerably higher than those for the individual scores (-0.24 to 0.68). The GLM-RMSD can thus predict the accuracy of protein structures more reliably than individual coordinate-based quality scores. Copyright © 2011 The Protein Society.

  15. Modeling psychophysical data at the population-level: the generalized linear mixed model.

    Science.gov (United States)

    Moscatelli, Alessandro; Mezzetti, Maura; Lacquaniti, Francesco

    2012-10-25

    In psychophysics, researchers usually apply a two-level model for the analysis of the behavior of the single subject and the population. This classical model has two main disadvantages. First, the second level of the analysis discards information on trial repetitions and subject-specific variability. Second, the model does not easily allow assessing the goodness of fit. As an alternative to this classical approach, here we propose the Generalized Linear Mixed Model (GLMM). The GLMM separately estimates the variability of fixed and random effects, it has a higher statistical power, and it allows an easier assessment of the goodness of fit compared with the classical two-level model. GLMMs have been frequently used in many disciplines since the 1990s; however, they have been rarely applied in psychophysics. Furthermore, to our knowledge, the issue of estimating the point-of-subjective-equivalence (PSE) within the GLMM framework has never been addressed. Therefore the article has two purposes: It provides a brief introduction to the usage of the GLMM in psychophysics, and it evaluates two different methods to estimate the PSE and its variability within the GLMM framework. We compare the performance of the GLMM and the classical two-level model on published experimental data and simulated data. We report that the estimated values of the parameters were similar between the two models and Type I errors were below the confidence level in both models. However, the GLMM has a higher statistical power than the two-level model. Moreover, one can easily compare the fit of different GLMMs according to different criteria. In conclusion, we argue that the GLMM can be a useful method in psychophysics.

  16. Node-Splitting Generalized Linear Mixed Models for Evaluation of Inconsistency in Network Meta-Analysis.

    Science.gov (United States)

    Yu-Kang, Tu

    2016-12-01

    Network meta-analysis for multiple treatment comparisons has been a major development in evidence synthesis methodology. The validity of a network meta-analysis, however, can be threatened by inconsistency in evidence within the network. One particular issue of inconsistency is how to directly evaluate the inconsistency between direct and indirect evidence with regard to the effects difference between two treatments. A Bayesian node-splitting model was first proposed and a similar frequentist side-splitting model has been put forward recently. Yet, assigning the inconsistency parameter to one or the other of the two treatments or splitting the parameter symmetrically between the two treatments can yield different results when multi-arm trials are involved in the evaluation. We aimed to show that a side-splitting model can be viewed as a special case of design-by-treatment interaction model, and different parameterizations correspond to different design-by-treatment interactions. We demonstrated how to evaluate the side-splitting model using the arm-based generalized linear mixed model, and an example data set was used to compare results from the arm-based models with those from the contrast-based models. The three parameterizations of side-splitting make slightly different assumptions: the symmetrical method assumes that both treatments in a treatment contrast contribute to inconsistency between direct and indirect evidence, whereas the other two parameterizations assume that only one of the two treatments contributes to this inconsistency. With this understanding in mind, meta-analysts can then make a choice about how to implement the side-splitting method for their analysis. Copyright © 2016 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  17. Generalized Functional Linear Models for Gene-based Case-Control Association Studies

    Science.gov (United States)

    Mills, James L.; Carter, Tonia C.; Lobach, Iryna; Wilson, Alexander F.; Bailey-Wilson, Joan E.; Weeks, Daniel E.; Xiong, Momiao

    2014-01-01

    By using functional data analysis techniques, we developed generalized functional linear models for testing association between a dichotomous trait and multiple genetic variants in a genetic region while adjusting for covariates. Both fixed and mixed effect models are developed and compared. Extensive simulations show that Rao's efficient score tests of the fixed effect models are very conservative since they generate lower type I errors than nominal levels, and global tests of the mixed effect models generate accurate type I errors. Furthermore, we found that the Rao's efficient score test statistics of the fixed effect models have higher power than the sequence kernel association test (SKAT) and its optimal unified version (SKAT-O) in most cases when the causal variants are both rare and common. When the causal variants are all rare (i.e., minor allele frequencies less than 0.03), the Rao's efficient score test statistics and the global tests have similar or slightly lower power than SKAT and SKAT-O. In practice, it is not known whether rare variants or common variants in a gene are disease-related. All we can assume is that a combination of rare and common variants influences disease susceptibility. Thus, the improved performance of our models when the causal variants are both rare and common shows that the proposed models can be very useful in dissecting complex traits. We compare the performance of our methods with SKAT and SKAT-O on real neural tube defects and Hirschsprung's disease data sets. The Rao's efficient score test statistics and the global tests are more sensitive than SKAT and SKAT-O in the real data analysis. Our methods can be used in either gene-disease genome-wide/exome-wide association studies or candidate gene analyses. PMID:25203683

  18. The Spike-and-Slab Lasso Generalized Linear Models for Prediction and Associated Genes Detection.

    Science.gov (United States)

    Tang, Zaixiang; Shen, Yueping; Zhang, Xinyan; Yi, Nengjun

    2017-01-01

    Large-scale "omics" data have been increasingly used as an important resource for prognostic prediction of diseases and detection of associated genes. However, there are considerable challenges in analyzing high-dimensional molecular data, including the large number of potential molecular predictors, limited number of samples, and small effect of each predictor. We propose new Bayesian hierarchical generalized linear models, called spike-and-slab lasso GLMs, for prognostic prediction and detection of associated genes using large-scale molecular data. The proposed model employs a spike-and-slab mixture double-exponential prior for coefficients that can induce weak shrinkage on large coefficients, and strong shrinkage on irrelevant coefficients. We have developed a fast and stable algorithm to fit large-scale hierarchal GLMs by incorporating expectation-maximization (EM) steps into the fast cyclic coordinate descent algorithm. The proposed approach integrates nice features of two popular methods, i.e., penalized lasso and Bayesian spike-and-slab variable selection. The performance of the proposed method is assessed via extensive simulation studies. The results show that the proposed approach can provide not only more accurate estimates of the parameters, but also better prediction. We demonstrate the proposed procedure on two cancer data sets: a well-known breast cancer data set consisting of 295 tumors, and expression data of 4919 genes; and the ovarian cancer data set from TCGA with 362 tumors, and expression data of 5336 genes. Our analyses show that the proposed procedure can generate powerful models for predicting outcomes and detecting associated genes. The methods have been implemented in a freely available R package BhGLM (http://www.ssg.uab.edu/bhglm/). Copyright © 2017 by the Genetics Society of America.

  19. Assessing the Tangent Linear Behaviour of Common Tracer Transport Schemes and Their Use in a Linearised Atmospheric General Circulation Model

    Science.gov (United States)

    Holdaway, Daniel; Kent, James

    2015-01-01

    The linearity of a selection of common advection schemes is tested and examined with a view to their use in the tangent linear and adjoint versions of an atmospheric general circulation model. The schemes are tested within a simple offline one-dimensional periodic domain as well as using a simplified and complete configuration of the linearised version of NASA's Goddard Earth Observing System version 5 (GEOS-5). All schemes which prevent the development of negative values and preserve the shape of the solution are confirmed to have nonlinear behaviour. The piecewise parabolic method (PPM) with certain flux limiters, including that used by default in GEOS-5, is found to support linear growth near the shocks. This property can cause the rapid development of unrealistically large perturbations within the tangent linear and adjoint models. It is shown that these schemes with flux limiters should not be used within the linearised version of a transport scheme. The results from tests using GEOS-5 show that the current default scheme (a version of PPM) is not suitable for the tangent linear and adjoint model, and that using a linear third-order scheme for the linearised model produces better behaviour. Using the third-order scheme for the linearised model improves the correlations between the linear and non-linear perturbation trajectories for cloud liquid water and cloud liquid ice in GEOS-5.

  20. Independent production and Poisson distribution

    International Nuclear Information System (INIS)

    Golokhvastov, A.I.

    1994-01-01

    The well-known statement of factorization of inclusive cross-sections in case of independent production of particles (or clusters, jets etc.) and the conclusion of Poisson distribution over their multiplicity arising from it do not follow from the probability theory in any way. Using accurately the theorem of the product of independent probabilities, quite different equations are obtained and no consequences relative to multiplicity distributions are obtained. 11 refs

  1. Poisson-Boltzmann versus Size-Modified Poisson-Boltzmann Electrostatics Applied to Lipid Bilayers.

    Science.gov (United States)

    Wang, Nuo; Zhou, Shenggao; Kekenes-Huskey, Peter M; Li, Bo; McCammon, J Andrew

    2014-12-26

    Mean-field methods, such as the Poisson-Boltzmann equation (PBE), are often used to calculate the electrostatic properties of molecular systems. In the past two decades, an enhancement of the PBE, the size-modified Poisson-Boltzmann equation (SMPBE), has been reported. Here, the PBE and the SMPBE are reevaluated for realistic molecular systems, namely, lipid bilayers, under eight different sets of input parameters. The SMPBE appears to reproduce the molecular dynamics simulation results better than the PBE only under specific parameter sets, but in general, it performs no better than the Stern layer correction of the PBE. These results emphasize the need for careful discussions of the accuracy of mean-field calculations on realistic systems with respect to the choice of parameters and call for reconsideration of the cost-efficiency and the significance of the current SMPBE formulation.

  2. Genetic parameters for feather pecking and aggressive behavior in a large F2-cross of laying hens using generalized linear mixed models.

    Science.gov (United States)

    Bennewitz, J; Bögelein, S; Stratz, P; Rodehutscord, M; Piepho, H P; Kjaer, J B; Bessei, W

    2014-04-01

    Feather pecking and aggressive pecking is a well-known problem in egg production. In the present study, genetic parameters for 4 feather-pecking-related traits were estimated using generalized linear mixed models. The traits were bouts of feather pecking delivered (FPD), bouts of feather pecking received (FPR), bouts of aggressive pecking delivered (APD), and bouts of aggressive pecking received (APR). An F2-design was established from 2 divergent selected founder lines. The lines were selected for low or high feather pecking for 10 generations. The number of F2 hens was 910. They were housed in pens with around 40 birds. Each pen was observed in 21 sessions of 20 min, distributed over 3 consecutive days. An animal model was applied that treated the bouts observed within 20 min as repeated observations. An over-dispersed Poisson distribution was assumed for observed counts and the link function was a log link. The model included a random animal effect, a random permanent environment effect, and a random day-by-hen effect. Residual variance was approximated on the link scale by the delta method. The results showed a heritability around 0.10 on the link scale for FPD and APD and of 0.04 for APR. The heritability of FPR was zero. For all behavior traits, substantial permanent environmental effects were observed. The approximate genetic correlation between FPD and APD (FPD and APR) was 0.81 (0.54). Egg production and feather eating records were collected on the same hens as well and were analyzed with a generalized linear mixed model, assuming a binomial distribution and using a probit link function. The heritability on the link scale for egg production was 0.40 and for feather eating 0.57. The approximate genetic correlation between FPD and egg production was 0.50 and between FPD and feather eating 0.73. Selection might help to reduce feather pecking, but this might result in an unfavorable correlated selection response reducing egg production. Feather eating and

  3. High Order A-stable Continuous General Linear Methods for Solution of Systems of Initial Value Problems in ODEs

    Directory of Open Access Journals (Sweden)

    Dauda GuliburYAKUBU

    2012-12-01

    Full Text Available Accurate solutions to initial value systems of ordinary differential equations may be approximated efficiently by Runge-Kutta methods or linear multistep methods. Each of these has limitations of one sort or another. In this paper we consider, as a middle ground, the derivation of continuous general linear methods for solution of stiff systems of initial value problems in ordinary differential equations. These methods are designed to combine the advantages of both Runge-Kutta and linear multistep methods. Particularly, methods possessing the property of A-stability are identified as promising methods within this large class of general linear methods. We show that the continuous general linear methods are self-starting and have more ability to solve the stiff systems of ordinary differential equations, than the discrete ones. The initial value systems of ordinary differential equations are solved, for instance, without looking for any other method to start the integration process. This desirable feature of the proposed approach leads to obtaining very high accuracy of the solution of the given problem. Illustrative examples are given to demonstrate the novelty and reliability of the methods.

  4. Spatial Modeling of Flood Duration in Amazonian Floodplains Through Radar Remote Sensing and Generalized Linear Models

    Science.gov (United States)

    Ferreira-Ferreira, J.; Francisco, M. S.; Silva, T. S. F.

    2017-12-01

    Amazon floodplains play an important role in biodiversity maintenance and provide important ecosystem services. Flood duration is the prime factor modulating biogeochemical cycling in Amazonian floodplain systems, as well as influencing ecosystem structure and function. However, due to the absence of accurate terrain information, fine-scale hydrological modeling is still not possible for most of the Amazon floodplains, and little is known regarding the spatio-temporal behavior of flooding in these environments. Our study presents an new approach for spatial modeling of flood duration, using Synthetic Aperture Radar (SAR) and Generalized Linear Modeling. Our focal study site was Mamirauá Sustainable Development Reserve, in the Central Amazon. We acquired a series of L-band ALOS-1/PALSAR Fine-Beam mosaics, chosen to capture the widest possible range of river stage heights at regular intervals. We then mapped flooded area on each image, and used the resulting binary maps as the response variable (flooded/non-flooded) for multiple logistic regression. Explanatory variables were accumulated precipitation 15 days prior and the water stage height recorded in the Mamirauá lake gauging station observed for each image acquisition date, Euclidean distance from the nearest drainage, and slope, terrain curvature, profile curvature, planform curvature and Height Above the Nearest Drainage (HAND) derived from the 30-m SRTM DEM. Model results were validated with water levels recorded by ten pressure transducers installed within the floodplains, from 2014 to 2016. The most accurate model included water stage height and HAND as explanatory variables, yielding a RMSE of ±38.73 days of flooding per year when compared to the ground validation sites. The largest disagreements were 57 days and 83 days for two validation sites, while remaining locations achieved absolute errors lower than 38 days. In five out of nine validation sites, the model predicted flood durations with

  5. glmmTMB balances speed and flexibility among packages for Zero-inflated Generalized Linear Mixed Modeling

    DEFF Research Database (Denmark)

    Brooks, Mollie Elizabeth; Kristensen, Kasper; van Benthem, Koen J.

    2017-01-01

    Count data can be analyzed using generalized linear mixed models when observations are correlated in ways that require random effects. However, count data are often zero-inflated, containing more zeros than would be expected from the typical error distributions. We present a new package, glmm...

  6. A methodology for evaluation of parent-mutant competition using a generalized non-linear ecosystem model

    Science.gov (United States)

    Raymond L. Czaplewski

    1973-01-01

    A generalized, non-linear population dynamics model of an ecosystem is used to investigate the direction of selective pressures upon a mutant by studying the competition between parent and mutant populations. The model has the advantages of considering selection as operating on the phenotype, of retaining the interaction of the mutant population with the ecosystem as a...

  7. Poisson sigma model with branes and hyperelliptic Riemann surfaces

    International Nuclear Information System (INIS)

    Ferrario, Andrea

    2008-01-01

    We derive the explicit form of the superpropagators in the presence of general boundary conditions (coisotropic branes) for the Poisson sigma model. This generalizes the results presented by Cattaneo and Felder [''A path integral approach to the Kontsevich quantization formula,'' Commun. Math. Phys. 212, 591 (2000)] and Cattaneo and Felder ['Coisotropic submanifolds in Poisson geometry and branes in the Poisson sigma model', Lett. Math. Phys. 69, 157 (2004)] for Kontsevich's angle function [Kontsevich, M., 'Deformation quantization of Poisson manifolds I', e-print arXiv:hep.th/0101170] used in the deformation quantization program of Poisson manifolds. The relevant superpropagators for n branes are defined as gauge fixed homotopy operators of a complex of differential forms on n sided polygons P n with particular ''alternating'' boundary conditions. In the presence of more than three branes we use first order Riemann theta functions with odd singular characteristics on the Jacobian variety of a hyperelliptic Riemann surface (canonical setting). In genus g the superpropagators present g zero mode contributions

  8. A geometric view on Pearson’s correlation coefficient and a generalization of it to non-linear dependencies

    Directory of Open Access Journals (Sweden)

    Priyantha Wijayatunga

    2016-06-01

    Full Text Available Measuring strength or degree of statistical dependence between two random variables is a common problem in many domains. Pearson’s correlation coefficient ρ is an accurate measure of linear dependence. We show that ρ is a normalized, Euclidean type distance between joint probability distribution of the two random variables and that when their independence is assumed while keeping their marginal distributions. And the normalizing constant is the geometric mean of two maximal distances; each between the joint probability distribution when the full linear dependence is assumed while preserving respective marginal distribution and that when the independence is assumed. Usage of it is restricted to linear dependence because it is based on Euclidean type distances that are generally not metrics and considered full dependence is linear. Therefore, we argue that if a suitable distance metric is used while considering all possible maximal dependences then it can measure any non-linear dependence. But then, one must define all the full dependences. Hellinger distance that is a metric can be used as the distance measure between probability distributions and obtain a generalization of ρ for the discrete case.

  9. A unified approach to the stability of generalized static neural networks with linear fractional uncertainties and delays.

    Science.gov (United States)

    Li, Xianwei; Gao, Huijun; Yu, Xinghuo

    2011-10-01

    In this paper, the robust global asymptotic stability (RGAS) of generalized static neural networks (SNNs) with linear fractional uncertainties and a constant or time-varying delay is concerned within a novel input-output framework. The activation functions in the model are assumed to satisfy a more general condition than the usually used Lipschitz-type ones. First, by four steps of technical transformations, the original generalized SNN model is equivalently converted into the interconnection of two subsystems, where the forward one is a linear time-invariant system with a constant delay while the feedback one bears the norm-bounded property. Then, based on the scaled small gain theorem, delay-dependent sufficient conditions for the RGAS of generalized SNNs are derived via combining a complete Lyapunov functional and the celebrated discretization scheme. All the results are given in terms of linear matrix inequalities so that the RGAS problem of generalized SNNs is projected into the feasibility of convex optimization problems that can be readily solved by effective numerical algorithms. The effectiveness and superiority of our results over the existing ones are demonstrated by two numerical examples.

  10. Recent advances toward a general purpose linear-scaling quantum force field.

    Science.gov (United States)

    Giese, Timothy J; Huang, Ming; Chen, Haoyuan; York, Darrin M

    2014-09-16

    Conspectus There is need in the molecular simulation community to develop new quantum mechanical (QM) methods that can be routinely applied to the simulation of large molecular systems in complex, heterogeneous condensed phase environments. Although conventional methods, such as the hybrid quantum mechanical/molecular mechanical (QM/MM) method, are adequate for many problems, there remain other applications that demand a fully quantum mechanical approach. QM methods are generally required in applications that involve changes in electronic structure, such as when chemical bond formation or cleavage occurs, when molecules respond to one another through polarization or charge transfer, or when matter interacts with electromagnetic fields. A full QM treatment, rather than QM/MM, is necessary when these features present themselves over a wide spatial range that, in some cases, may span the entire system. Specific examples include the study of catalytic events that involve delocalized changes in chemical bonds, charge transfer, or extensive polarization of the macromolecular environment; drug discovery applications, where the wide range of nonstandard residues and protonation states are challenging to model with purely empirical MM force fields; and the interpretation of spectroscopic observables. Unfortunately, the enormous computational cost of conventional QM methods limit their practical application to small systems. Linear-scaling electronic structure methods (LSQMs) make possible the calculation of large systems but are still too computationally intensive to be applied with the degree of configurational sampling often required to make meaningful comparison with experiment. In this work, we present advances in the development of a quantum mechanical force field (QMFF) suitable for application to biological macromolecules and condensed phase simulations. QMFFs leverage the benefits provided by the LSQM and QM/MM approaches to produce a fully QM method that is able to

  11. Sparse non-linear denoising: Generalization performance and pattern reproducibility in functional MRI

    DEFF Research Database (Denmark)

    Abrahamsen, Trine Julie; Hansen, Lars Kai

    2011-01-01

    We investigate sparse non-linear denoising of functional brain images by kernel Principal Component Analysis (kernel PCA). The main challenge is the mapping of denoised feature space points back into input space, also referred to as ”the pre-image problem”. Since the feature space mapping is typi...

  12. A GENERAL-SOLUTION FOR A CLASS OF WEAKLY CONSTRAINED LINEAR-REGRESSION PROBLEMS

    NARCIS (Netherlands)

    TENBERGE, JMF

    1991-01-01

    This paper contains a globally optimal solution for a class of functions composed of a linear regression function and a penalty function for the sum of squared regression weights. Global optimality is obtained from inequalities rather than from partial derivatives of a Lagrangian function.

  13. Mean and quasideterministic equivalence for linear stochastic dynamics.

    Science.gov (United States)

    Hanson, F B; Ryan, D

    1989-03-01

    In linear, stochastic dynamics it is shown that the quasideterministic population size is equivalent to the mean population size. The quasideterministic dynamics are defined by the conditional infinitesimal mean of the process. The stochastic component of the dynamics includes both Gaussian and Poisson white noise, with amplitude coefficients proportional to the population size. Generalizations are given for nonautonomous coefficients and for distributed Poisson jump amplitudes. A counter example--an exactly integrable nonlinear jump model--shows that the equivalence result does not hold for nonlinear stochastic dynamics.

  14. Large deformation image classification using generalized locality-constrained linear coding.

    Science.gov (United States)

    Zhang, Pei; Wee, Chong-Yaw; Niethammer, Marc; Shen, Dinggang; Yap, Pew-Thian

    2013-01-01

    Magnetic resonance (MR) imaging has been demonstrated to be very useful for clinical diagnosis of Alzheimer's disease (AD). A common approach to using MR images for AD detection is to spatially normalize the images by non-rigid image registration, and then perform statistical analysis on the resulting deformation fields. Due to the high nonlinearity of the deformation field, recent studies suggest to use initial momentum instead as it lies in a linear space and fully encodes the deformation field. In this paper we explore the use of initial momentum for image classification by focusing on the problem of AD detection. Experiments on the public ADNI dataset show that the initial momentum, together with a simple sparse coding technique-locality-constrained linear coding (LLC)--can achieve a classification accuracy that is comparable to or even better than the state of the art. We also show that the performance of LLC can be greatly improved by introducing proper weights to the codebook.

  15. Non-linear partial differential equations an algebraic view of generalized solutions

    CERN Document Server

    Rosinger, Elemer E

    1990-01-01

    A massive transition of interest from solving linear partial differential equations to solving nonlinear ones has taken place during the last two or three decades. The availability of better computers has often made numerical experimentations progress faster than the theoretical understanding of nonlinear partial differential equations. The three most important nonlinear phenomena observed so far both experimentally and numerically, and studied theoretically in connection with such equations have been the solitons, shock waves and turbulence or chaotical processes. In many ways, these phenomen

  16. Continuity and general perturbation of the Drazin inverse for closed linear operators

    Directory of Open Access Journals (Sweden)

    N. Castro González

    2002-01-01

    Full Text Available We study perturbations and continuity of the Drazin inverse of a closed linear operator A and obtain explicit error estimates in terms of the gap between closed operators and the gap between ranges and nullspaces of operators. The results are used to derive a theorem on the continuity of the Drazin inverse for closed operators and to describe the asymptotic behavior of operator semigroups.

  17. Generalized linear differential equations in a Banach space : continuous dependence on a parameter

    Czech Academy of Sciences Publication Activity Database

    Monteiro, G.A.; Tvrdý, Milan

    2013-01-01

    Roč. 33, č. 1 (2013), s. 283-303 ISSN 1078-0947 Institutional research plan: CEZ:AV0Z10190503 Keywords : generalized differential equations * continuous dependence * Kurzweil-Stieltjes integral Subject RIV: BA - General Mathematics Impact factor: 0.923, year: 2013 http://aimsciences.org/journals/displayArticlesnew.jsp?paperID=7615

  18. Generalized Forecast Error Variance Decomposition for Linear and Nonlinear Multivariate Models

    DEFF Research Database (Denmark)

    Lanne, Markku; Nyberg, Henri

    We propose a new generalized forecast error variance decomposition with the property that the proportions of the impact accounted for by innovations in each variable sum to unity. Our decomposition is based on the well-established concept of the generalized impulse response function. The use...

  19. The Quantum Poisson Bracket and Transformation Theory in ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 8; Issue 8. The Quantum Poisson Bracket and Transformation Theory in Quantum Mechanics: Dirac's Early Work in Quantum Theory. Kamal Datta. General Article Volume 8 Issue 8 August 2003 pp 75-85 ...

  20. Inhibition in speed and concentration tests: The Poisson inhibition model

    NARCIS (Netherlands)

    Smit, J.C.; Ven, A.H.G.S. van der

    1995-01-01

    A new model is presented to account for the reaction time fluctuations in concentration tests. The model is a natural generalization of an earlier model, the so-called Poisson-Erlang model, published by Pieters & van der Ven (1982). First, a description is given of the type of tasks for which the

  1. Boundary singularity of Poisson and harmonic Bergman kernels

    Czech Academy of Sciences Publication Activity Database

    Engliš, Miroslav

    2015-01-01

    Roč. 429, č. 1 (2015), s. 233-272 ISSN 0022-247X R&D Projects: GA AV ČR IAA100190802 Institutional support: RVO:67985840 Keywords : harmonic Bergman kernel * Poisson kernel * pseudodifferential boundary operators Subject RIV: BA - General Mathematics Impact factor: 1.014, year: 2015 http://www.sciencedirect.com/science/article/pii/S0022247X15003170

  2. Characterization and global analysis of a family of Poisson structures

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez-Bermejo, Benito [Escuela Superior de Ciencias Experimentales y Tecnologia, Edificio Departamental II, Universidad Rey Juan Carlos, Calle Tulipan S/N, 28933 (Mostoles), Madrid (Spain)]. E-mail: benito.hernandez@urjc.es

    2006-06-26

    A three-dimensional family of solutions of the Jacobi equations for Poisson systems is characterized. In spite of its general form it is possible the explicit and global determination of its main features, such as the symplectic structure and the construction of the Darboux canonical form. Examples are given.

  3. Efficient triangulation of Poisson-disk sampled point sets

    KAUST Repository

    Guo, Jianwei

    2014-05-06

    In this paper, we present a simple yet efficient algorithm for triangulating a 2D input domain containing a Poisson-disk sampled point set. The proposed algorithm combines a regular grid and a discrete clustering approach to speedup the triangulation. Moreover, our triangulation algorithm is flexible and performs well on more general point sets such as adaptive, non-maximal Poisson-disk sets. The experimental results demonstrate that our algorithm is robust for a wide range of input domains and achieves significant performance improvement compared to the current state-of-the-art approaches. © 2014 Springer-Verlag Berlin Heidelberg.

  4. Gyrokinetic energy conservation and Poisson-bracket formulation

    International Nuclear Information System (INIS)

    Brizard, A.

    1988-11-01

    An integral expression for the gyrokinetic total energy of a magnetized plasma with general magnetic field configuration perturbed by fully electromagnetic fields was recently derived through the use of a gyro-center Lie transformation. We show that the gyrokinetic energy is conserved by the gyrokinetic Hamiltonian flow to all orders in perturbed fields. This paper is concerned with the explicit demonstration that a gyrokinetic Hamiltonian containing quadratic nonlinearities preserves the gyrokinetic energy up to third order. The Poisson-bracket formulation greatly facilitates this demonstration with the help of the Jacobi identity and other properties of the Poisson brackets. 18 refs

  5. Efficient maximal Poisson-disk sampling and remeshing on surfaces

    KAUST Repository

    Guo, Jianwei

    2015-02-01

    Poisson-disk sampling is one of the fundamental research problems in computer graphics that has many applications. In this paper, we study the problem of maximal Poisson-disk sampling on mesh surfaces. We present a simple approach that generalizes the 2D maximal sampling framework to surfaces. The key observation is to use a subdivided mesh as the sampling domain for conflict checking and void detection. Our approach improves the state-of-the-art approach in efficiency, quality and the memory consumption.

  6. Markov modulated Poisson process models incorporating covariates for rainfall intensity.

    Science.gov (United States)

    Thayakaran, R; Ramesh, N I

    2013-01-01

    Time series of rainfall bucket tip times at the Beaufort Park station, Bracknell, in the UK are modelled by a class of Markov modulated Poisson processes (MMPP) which may be thought of as a generalization of the Poisson process. Our main focus in this paper is to investigate the effects of including covariate information into the MMPP model framework on statistical properties. In particular, we look at three types of time-varying covariates namely temperature, sea level pressure, and relative humidity that are thought to be affecting the rainfall arrival process. Maximum likelihood estimation is used to obtain the parameter estimates, and likelihood ratio tests are employed in model comparison. Simulated data from the fitted model are used to make statistical inferences about the accumulated rainfall in the discrete time interval. Variability of the daily Poisson arrival rates is studied.

  7. The coupling of Poisson sigma models to topological backgrounds

    Energy Technology Data Exchange (ETDEWEB)

    Rosa, Dario [School of Physics, Korea Institute for Advanced Study,Seoul 02455 (Korea, Republic of)

    2016-12-13

    We extend the coupling to the topological backgrounds, recently worked out for the 2-dimensional BF-model, to the most general Poisson sigma models. The coupling involves the choice of a Casimir function on the target manifold and modifies the BRST transformations. This in turn induces a change in the BRST cohomology of the resulting theory. The observables of the coupled theory are analyzed and their geometrical interpretation is given. We finally couple the theory to 2-dimensional topological gravity: this is the first step to study a topological string theory in propagation on a Poisson manifold. As an application, we show that the gauge-fixed vectorial supersymmetry of the Poisson sigma models has a natural explanation in terms of the theory coupled to topological gravity.

  8. Effect of Poisson noise on adiabatic quantum control

    Science.gov (United States)

    Kiely, A.; Muga, J. G.; Ruschhaupt, A.

    2017-01-01

    We present a detailed derivation of the master equation describing a general time-dependent quantum system with classical Poisson white noise and outline its various properties. We discuss the limiting cases of Poisson white noise and provide approximations for the different noise strength regimes. We show that using the eigenstates of the noise superoperator as a basis can be a useful way of expressing the master equation. Using this, we simulate various settings to illustrate different effects of Poisson noise. In particular, we show a dip in the fidelity as a function of noise strength where high fidelity can occur in the strong-noise regime for some cases. We also investigate recent claims [J. Jing et al., Phys. Rev. A 89, 032110 (2014), 10.1103/PhysRevA.89.032110] that this type of noise may improve rather than destroy adiabaticity.

  9. Expected estimating equation using calibration data for generalized linear models with a mixture of Berkson and classical errors in covariates.

    Science.gov (United States)

    Tapsoba, Jean de Dieu; Lee, Shen-Ming; Wang, Ching-Yun

    2014-02-20

    Data collected in many epidemiological or clinical research studies are often contaminated with measurement errors that may be of classical or Berkson error type. The measurement error may also be a combination of both classical and Berkson errors and failure to account for both errors could lead to unreliable inference in many situations. We consider regression analysis in generalized linear models when some covariates are prone to a mixture of Berkson and classical errors, and calibration data are available only for some subjects in a subsample. We propose an expected estimating equation approach to accommodate both errors in generalized linear regression analyses. The proposed method can consistently estimate the classical and Berkson error variances based on the available data, without knowing the mixture percentage. We investigated its finite-sample performance numerically. Our method is illustrated by an application to real data from an HIV vaccine study. Copyright © 2013 John Wiley & Sons, Ltd.

  10. A general purpose non-linear curve fitting program for the British Broadcasting Corporation Microcomputer.

    Science.gov (United States)

    Beynon, R J

    1985-01-01

    Software for non-linear curve fitting has been written in BASIC to execute on the British Broadcasting Corporation Microcomputer. The program uses the direct search algorithm Pattern-search, a robust algorithm that has the additional advantage of needing specification of the function without inclusion of the partial derivatives. Although less efficient than gradient methods, the program can be readily configured to solve low-dimensional optimization problems that are normally encountered in life sciences. In writing the software, emphasis has been placed upon the 'user interface' and making the most efficient use of the facilities provided by the minimal configuration of this system.

  11. Principal components and generalized linear modeling in the correlation between hospital admissions and air pollution.

    Science.gov (United States)

    Souza, Juliana Bottoni de; Reisen, Valdério Anselmo; Santos, Jane Méri; Franco, Glaura Conceição

    2014-06-01

    OBJECTIVE To analyze the association between concentrations of air pollutants and admissions for respiratory causes in children. METHODS Ecological time series study. Daily figures for hospital admissions of children aged generalized additive models and principal model component analysis. Those analysis techniques complemented each other and provided more significant estimates in the estimation of relative risk. The models were adjusted for temporal trend, seasonality, day of the week, meteorological factors and autocorrelation. In the final adjustment of the model, it was necessary to include models of the Autoregressive Moving Average Models (p, q) type in the residuals in order to eliminate the autocorrelation structures present in the components. RESULTS For every 10:49 μg/m3 increase (interquartile range) in levels of the pollutant PM10 there was a 3.0% increase in the relative risk estimated using the generalized additive model analysis of main components-seasonal autoregressive - while in the usual generalized additive model, the estimate was 2.0%. CONCLUSIONS Compared to the usual generalized additive model, in general, the proposed aspect of generalized additive model - principal component analysis, showed better results in estimating relative risk and quality of fit.

  12. Solution of a General Linear Complementarity Problem Using Smooth Optimization and Its Application to Bilinear Programming and LCP

    International Nuclear Information System (INIS)

    Fernandes, L.; Friedlander, A.; Guedes, M.; Judice, J.

    2001-01-01

    This paper addresses a General Linear Complementarity Problem (GLCP) that has found applications in global optimization. It is shown that a solution of the GLCP can be computed by finding a stationary point of a differentiable function over a set defined by simple bounds on the variables. The application of this result to the solution of bilinear programs and LCPs is discussed. Some computational evidence of its usefulness is included in the last part of the paper

  13. New classical r-matrices from integrable non-linear sigma-models

    International Nuclear Information System (INIS)

    Laartz, J.; Bordemann, M.; Forger, M.; Schaper, U.

    1993-01-01

    Non-linear sigma models on Riemannian symmetric spaces constitute the most general class of classical non-linear sigma models which are known to be integrable. Using the current algebra structure of these models their canonical structure is analyzed and it is shown that their non-ultralocal fundamental Poisson bracket relation is governed by a field dependent non antisymmetric r-matrix obeying a dynamical Yang Baxter equation. The fundamental Poisson bracket relations and the r-matrix are derived explicitly and a new kind of algebra is found that is supposed to replace the classical Yang Baxter algebra governing the canonical structure of ultralocal models. (Author) 9 refs

  14. [Explore the influence factors on primary lung cancer in Fujian province Han population under the use of generalized linear model].

    Science.gov (United States)

    He, Fei; Xiao, Rendong; Yu, Tingting; Zhang, Xin; Liu, Zhiqiang; Cai, Lin

    2015-08-01

    The purpose of this study was to use the data on lung cancer in Han Chinese in Fujian province to explore the value of a generalized, linear model and to investigate the impact related to environment factors on lung cancer as well as the independent and interaction effects on the development of lung cancer. SAS 9.2 was used to build a generalized linear model to evaluate the influence factors and interaction of lung cancer on both smokers and non-smokers. Results showed that the relationship of the factors was multiplied. Under the logistic regression analysis, seven risk factors and nine risk factors were noticed in smokers or in non-smokers, respectively. Heavy smokers and lung diseases appeared a positive multiplying effect on smokers while passive smoking and fresh fruits showed positive multiplying effects on non-smokers. The generalized linear models could filter suitable models thus facilitating further research on the interaction between the two. It seemed easy to carry on the comprehensive and rational analysis on related epidemiological data.

  15. Parasites et parasitoses des poissons

    OpenAIRE

    De Kinkelin, Pierre; Morand, Marc; Hedrick, Ronald; Michel, Christian

    2014-01-01

    Cet ouvrage, richement illustré, offre un panorama représentatif des agents parasitaires rencontrés chez les poissons. S'appuyant sur les nouvelles conceptions de la classification phylogénétique, il met l'accent sur les propriétés biologiques, l'épidémiologie et les conséquences cliniques des groupes d'organismes en cause, à la lumière des avancées cognitives permises par les nouveaux outils de la biologie. Il est destiné à un large public, allant du monde de l'aquaculture à ceux de la santé...

  16. Singular reduction of Nambu-Poisson manifolds

    Science.gov (United States)

    Das, Apurba

    The version of Marsden-Ratiu Poisson reduction theorem for Nambu-Poisson manifolds by a regular foliation have been studied by Ibáñez et al. In this paper, we show that this reduction procedure can be extended to the singular case. Under a suitable notion of Hamiltonian flow on the reduced space, we show that a set of Hamiltonians on a Nambu-Poisson manifold can also be reduced.

  17. Iterative solution of general sparse linear systems on clusters of workstations

    Energy Technology Data Exchange (ETDEWEB)

    Lo, Gen-Ching; Saad, Y. [Univ. of Minnesota, Minneapolis, MN (United States)

    1996-12-31

    Solving sparse irregularly structured linear systems on parallel platforms poses several challenges. First, sparsity makes it difficult to exploit data locality, whether in a distributed or shared memory environment. A second, perhaps more serious challenge, is to find efficient ways to precondition the system. Preconditioning techniques which have a large degree of parallelism, such as multicolor SSOR, often have a slower rate of convergence than their sequential counterparts. Finally, a number of other computational kernels such as inner products could ruin any gains gained from parallel speed-ups, and this is especially true on workstation clusters where start-up times may be high. In this paper we discuss these issues and report on our experience with PSPARSLIB, an on-going project for building a library of parallel iterative sparse matrix solvers.

  18. General rigid motion correction for computed tomography imaging based on locally linear embedding

    Science.gov (United States)

    Chen, Mianyi; He, Peng; Feng, Peng; Liu, Baodong; Yang, Qingsong; Wei, Biao; Wang, Ge

    2018-02-01

    The patient motion can damage the quality of computed tomography images, which are typically acquired in cone-beam geometry. The rigid patient motion is characterized by six geometric parameters and are more challenging to correct than in fan-beam geometry. We extend our previous rigid patient motion correction method based on the principle of locally linear embedding (LLE) from fan-beam to cone-beam geometry and accelerate the computational procedure with the graphics processing unit (GPU)-based all scale tomographic reconstruction Antwerp toolbox. The major merit of our method is that we need neither fiducial markers nor motion-tracking devices. The numerical and experimental studies show that the LLE-based patient motion correction is capable of calibrating the six parameters of the patient motion simultaneously, reducing patient motion artifacts significantly.

  19. Subsonic Flow for the Multidimensional Euler-Poisson System

    Science.gov (United States)

    Bae, Myoungjean; Duan, Ben; Xie, Chunjing

    2016-04-01

    We establish the existence and stability of subsonic potential flow for the steady Euler-Poisson system in a multidimensional nozzle of a finite length when prescribing the electric potential difference on a non-insulated boundary from a fixed point at the exit, and prescribing the pressure at the exit of the nozzle. The Euler-Poisson system for subsonic potential flow can be reduced to a nonlinear elliptic system of second order. In this paper, we develop a technique to achieve a priori {C^{1,α}} estimates of solutions to a quasi-linear second order elliptic system with mixed boundary conditions in a multidimensional domain enclosed by a Lipschitz continuous boundary. In particular, we discovered a special structure of the Euler-Poisson system which enables us to obtain {C^{1,α}} estimates of the velocity potential and the electric potential functions, and this leads us to establish structural stability of subsonic flows for the Euler-Poisson system under perturbations of various data.

  20. Size-extensive wave functions for quantum Monte Carlo: A linear scaling generalized valence bond approach

    NARCIS (Netherlands)

    Fracchia, F.; Filippi, Claudia; Amovilli, C.

    2012-01-01

    We propose a new class of multideterminantal Jastrow–Slater wave functions constructed with localized orbitals and designed to describe complex potential energy surfaces of molecular systems for use in quantum Monte Carlo (QMC). Inspired by the generalized valence bond formalism, we elaborate a

  1. A parallel Jacobi-Davidson method for solving generalized eigenvalue problems in linear magnetohydrodynamics

    NARCIS (Netherlands)

    M. Nool (Margreet); A. van der Ploeg (Auke)

    1997-01-01

    textabstractWe study the solution of generalized eigenproblems generated by a model which is used for stability investigation of tokamak plasmas. The eigenvalue problems are of the form $A x = lambda B x$, in which the complex matrices $A$ and $B$ are block tridiagonal, and $B$ is Hermitian positive

  2. Equilibrium arrival times to queues with general service times and non-linear utility functions

    DEFF Research Database (Denmark)

    Breinbjerg, Jesper

    2017-01-01

    by a general utility function which is decreasing in the waiting time and service completion time of each customer. Applications of such queueing games range from people choosing when to arrive at a grand opening sale to travellers choosing when to line up at the gate when boarding an airplane. We develop...

  3. The energy and the linear momentum of space-times in general relativity

    International Nuclear Information System (INIS)

    Schoen, R.; Yau, S.T.

    1981-01-01

    We extend our previous proof of the positive mass conjecture to allow a more general asymptotic condition proposed by York. Hence we are able to prove that for an isolated physical system, the energy momentum four vector is a future timelike vector unless the system is trivial. Furthermore, we allow singularities of the type of black holes. (orig.)

  4. Generalized W1;1-Young Measures and Relaxation of Problems with Linear Growth

    Czech Academy of Sciences Publication Activity Database

    Baia, M.; Krömer, Stefan; Kružík, Martin

    2018-01-01

    Roč. 50, č. 1 (2018), s. 1076-1119 ISSN 0036-1410 R&D Projects: GA ČR GA14-15264S; GA ČR(CZ) GF16-34894L Institutional support: RVO:67985556 Keywords : lower semicontinuity * quasiconvexity * Young measures Subject RIV: BA - General Mathematics OBOR OECD: Pure mathematics Impact factor: 1.648, year: 2016 http://library.utia.cas.cz/2018/MTR/kruzik-0487019. pdf

  5. A general soft label based linear discriminant analysis for semi-supervised dimensionality reduction.

    Science.gov (United States)

    Zhao, Mingbo; Zhang, Zhao; Chow, Tommy W S; Li, Bing

    2014-07-01

    Dealing with high-dimensional data has always been a major problem in research of pattern recognition and machine learning, and Linear Discriminant Analysis (LDA) is one of the most popular methods for dimension reduction. However, it only uses labeled samples while neglecting unlabeled samples, which are abundant and can be easily obtained in the real world. In this paper, we propose a new dimension reduction method, called "SL-LDA", by using unlabeled samples to enhance the performance of LDA. The new method first propagates label information from the labeled set to the unlabeled set via a label propagation process, where the predicted labels of unlabeled samples, called "soft labels", can be obtained. It then incorporates the soft labels into the construction of scatter matrixes to find a transformed matrix for dimension reduction. In this way, the proposed method can preserve more discriminative information, which is preferable when solving the classification problem. We further propose an efficient approach for solving SL-LDA under a least squares framework, and a flexible method of SL-LDA (FSL-LDA) to better cope with datasets sampled from a nonlinear manifold. Extensive simulations are carried out on several datasets, and the results show the effectiveness of the proposed method. Copyright © 2014 Elsevier Ltd. All rights reserved.

  6. Time evolution of linear and generalized Heisenberg algebra nonlinear Pöschl-Teller coherent states

    Science.gov (United States)

    Rego-Monteiro, M. A.; Curado, E. M. F.; Rodrigues, Ligia M. C. S.

    2017-11-01

    We analyze the time evolution of two kinds of coherent states for a particle in a Pöschl-Teller potential. We find a pair of canonically conjugate operators and compare the behavior of their time evolution for both coherent states. The nonlinear ones are more localized. The trajectory in the phase space of the mean values of these two operators is a kind of generalization of the Rose algebraic curves. The new pair of canonically conjugate variables leads to a fourth-order Schrödinger equation which has the same energy spectrum as the Pöschl-Teller system.

  7. General, database-driven fast-feedback system for the Stanford Linear Collider

    International Nuclear Information System (INIS)

    Rouse, F.; Allison, S.; Castillo, S.; Gromme, T.; Hall, B.; Hendrickson, L.; Himel, T.; Krauter, K.; Sass, B.; Shoaee, H.

    1991-05-01

    A new feedback system has been developed for stabilizing the SLC beams at many locations. The feedback loops are designed to sample and correct at the 60 Hz repetition rate of the accelerator. Each loop can be distributed across several of the standard 80386 microprocessors which control the SLC hardware. A new communications system, KISNet, has been implemented to pass signals between the microprocessors at this rate. The software is written in a general fashion using the state space formalism of digital control theory. This allows a new loop to be implemented by just setting up the online database and perhaps installing a communications link. 3 refs., 4 figs

  8. A generalized Lyapunov theory for robust root clustering of linear state space models with real parameter uncertainty

    Science.gov (United States)

    Yedavalli, R. K.

    1992-01-01

    The problem of analyzing and designing controllers for linear systems subject to real parameter uncertainty is considered. An elegant, unified theory for robust eigenvalue placement is presented for a class of D-regions defined by algebraic inequalities by extending the nominal matrix root clustering theory of Gutman and Jury (1981) to linear uncertain time systems. The author presents explicit conditions for matrix root clustering for different D-regions and establishes the relationship between the eigenvalue migration range and the parameter range. The bounds are all obtained by one-shot computation in the matrix domain and do not need any frequency sweeping or parameter gridding. The method uses the generalized Lyapunov theory for getting the bounds.

  9. Associative and Lie deformations of Poisson algebras

    OpenAIRE

    Remm, Elisabeth

    2011-01-01

    Considering a Poisson algebra as a non associative algebra satisfying the Markl-Remm identity, we study deformations of Poisson algebras as deformations of this non associative algebra. This gives a natural interpretation of deformations which preserves the underlying associative structure and we study deformations which preserve the underlying Lie algebra.

  10. Poisson Regression Analysis of Illness and Injury Surveillance Data

    Energy Technology Data Exchange (ETDEWEB)

    Frome E.L., Watkins J.P., Ellis E.D.

    2012-12-12

    The Department of Energy (DOE) uses illness and injury surveillance to monitor morbidity and assess the overall health of the work force. Data collected from each participating site include health events and a roster file with demographic information. The source data files are maintained in a relational data base, and are used to obtain stratified tables of health event counts and person time at risk that serve as the starting point for Poisson regression analysis. The explanatory variables that define these tables are age, gender, occupational group, and time. Typical response variables of interest are the number of absences due to illness or injury, i.e., the response variable is a count. Poisson regression methods are used to describe the effect of the explanatory variables on the health event rates using a log-linear main effects model. Results of fitting the main effects model are summarized in a tabular and graphical form and interpretation of model parameters is provided. An analysis of deviance table is used to evaluate the importance of each of the explanatory variables on the event rate of interest and to determine if interaction terms should be considered in the analysis. Although Poisson regression methods are widely used in the analysis of count data, there are situations in which over-dispersion occurs. This could be due to lack-of-fit of the regression model, extra-Poisson variation, or both. A score test statistic and regression diagnostics are used to identify over-dispersion. A quasi-likelihood method of moments procedure is used to evaluate and adjust for extra-Poisson variation when necessary. Two examples are presented using respiratory disease absence rates at two DOE sites to illustrate the methods and interpretation of the results. In the first example the Poisson main effects model is adequate. In the second example the score test indicates considerable over-dispersion and a more detailed analysis attributes the over-dispersion to extra-Poisson

  11. A simulation-based goodness-of-fit test for random effects in generalized linear mixed models

    DEFF Research Database (Denmark)

    Waagepetersen, Rasmus

    2006-01-01

    The goodness-of-fit of the distribution of random effects in a generalized linear mixed model is assessed using a conditional simulation of the random effects conditional on the observations. Provided that the specified joint model for random effects and observations is correct, the marginal...... distribution of the simulated random effects coincides with the assumed random effects distribution. In practice, the specified model depends on some unknown parameter which is replaced by an estimate. We obtain a correction for this by deriving the asymptotic distribution of the empirical distribution...

  12. A simulation-based goodness-of-fit test for random effects in generalized linear mixed models

    DEFF Research Database (Denmark)

    Waagepetersen, Rasmus Plenge

    The goodness-of-fit of the distribution of random effects in a generalized linear mixed model is assessed using a conditional simulation of the random effects conditional on the observations. Provided that the specified joint model for random effects and observations is correct, the marginal...... distribution of the simulated random effects coincides with the assumed random effects distribution. In practice the specified model depends on some unknown parameter which is replaced by an estimate. We obtain a correction for this by deriving the asymptotic distribution of the empirical distribution function...

  13. Generalized magnetic susceptibilities in metals: application of the analytic tetrahedron linear energy method to Sc

    International Nuclear Information System (INIS)

    Rath, J.; Freeman, A.J.

    1975-01-01

    A detailed study of the generalized susceptibility chi(vector q) of Sc metal determined from an accurate augmented-plane-wave method calculation of its energy-band structure is presented. The calculations were done by means of a computational scheme for chi(vector q) derived as an extension of the work of Jepsen and Andersen and Lehmann and Taut on the density-of-states problem. The procedure yields simple analytic expressions for the chi(vector q) integral inside a tetrahedral microzone of the Brillouin zone which depends only on the volume of the tetrahedron and the differences of the energies at its corners. Constant-matrix-element results have been obtained for Sc which show very good agreement with the results of Liu, Gupta, and Sinha (but with one less peak) and exhibit a first maximum in chi(vector q) at (0, 0, 0.31) 2π/c [vs (0, 0, 0.35) 2π/c obtained by Liu et al.] which relates very well to dilute rare-earth alloy magnetic ordering at vector q/sub m/ = (0, 0, 0.28) 2π/c and to the kink in the LA-phonon dispersion curve at (0, 0, 0.27) 2π/c. (U.S.)

  14. Modeling Linguistic Variables With Regression Models: Addressing Non-Gaussian Distributions, Non-independent Observations, and Non-linear Predictors With Random Effects and Generalized Additive Models for Location, Scale, and Shape.

    Science.gov (United States)

    Coupé, Christophe

    2018-01-01

    As statistical approaches are getting increasingly used in linguistics, attention must be paid to the choice of methods and algorithms used. This is especially true since they require assumptions to be satisfied to provide valid results, and because scientific articles still often fall short of reporting whether such assumptions are met. Progress is being, however, made in various directions, one of them being the introduction of techniques able to model data that cannot be properly analyzed with simpler linear regression models. We report recent advances in statistical modeling in linguistics. We first describe linear mixed-effects regression models (LMM), which address grouping of observations, and generalized linear mixed-effects models (GLMM), which offer a family of distributions for the dependent variable. Generalized additive models (GAM) are then introduced, which allow modeling non-linear parametric or non-parametric relationships between the dependent variable and the predictors. We then highlight the possibilities offered by generalized additive models for location, scale, and shape (GAMLSS). We explain how they make it possible to go beyond common distributions, such as Gaussian or Poisson, and offer the appropriate inferential framework to account for 'difficult' variables such as count data with strong overdispersion. We also demonstrate how they offer interesting perspectives on data when not only the mean of the dependent variable is modeled, but also its variance, skewness, and kurtosis. As an illustration, the case of phonemic inventory size is analyzed throughout the article. For over 1,500 languages, we consider as predictors the number of speakers, the distance from Africa, an estimation of the intensity of language contact, and linguistic relationships. We discuss the use of random effects to account for genealogical relationships, the choice of appropriate distributions to model count data, and non-linear relationships. Relying on GAMLSS, we

  15. Modeling Linguistic Variables With Regression Models: Addressing Non-Gaussian Distributions, Non-independent Observations, and Non-linear Predictors With Random Effects and Generalized Additive Models for Location, Scale, and Shape

    Directory of Open Access Journals (Sweden)

    Christophe Coupé

    2018-04-01

    Full Text Available As statistical approaches are getting increasingly used in linguistics, attention must be paid to the choice of methods and algorithms used. This is especially true since they require assumptions to be satisfied to provide valid results, and because scientific articles still often fall short of reporting whether such assumptions are met. Progress is being, however, made in various directions, one of them being the introduction of techniques able to model data that cannot be properly analyzed with simpler linear regression models. We report recent advances in statistical modeling in linguistics. We first describe linear mixed-effects regression models (LMM, which address grouping of observations, and generalized linear mixed-effects models (GLMM, which offer a family of distributions for the dependent variable. Generalized additive models (GAM are then introduced, which allow modeling non-linear parametric or non-parametric relationships between the dependent variable and the predictors. We then highlight the possibilities offered by generalized additive models for location, scale, and shape (GAMLSS. We explain how they make it possible to go beyond common distributions, such as Gaussian or Poisson, and offer the appropriate inferential framework to account for ‘difficult’ variables such as count data with strong overdispersion. We also demonstrate how they offer interesting perspectives on data when not only the mean of the dependent variable is modeled, but also its variance, skewness, and kurtosis. As an illustration, the case of phonemic inventory size is analyzed throughout the article. For over 1,500 languages, we consider as predictors the number of speakers, the distance from Africa, an estimation of the intensity of language contact, and linguistic relationships. We discuss the use of random effects to account for genealogical relationships, the choice of appropriate distributions to model count data, and non-linear relationships

  16. A Hierarchical Generalized Linear Model in Combination with Dispersion Modeling to Improve Sib-Pair Linkage Analysis.

    Science.gov (United States)

    Lee, Woojoo; Kim, Jeonghwan; Lee, Youngjo; Park, Taesung; Suh, Young Ju

    2015-01-01

    We explored a hierarchical generalized linear model (HGLM) in combination with dispersion modeling to improve the sib-pair linkage analysis based on the revised Haseman-Elston regression model for a quantitative trait. A dispersion modeling technique was investigated for sib-pair linkage analysis using simulation studies and real data applications. We considered 4 heterogeneous dispersion settings according to a signal-to-noise ratio (SNR) in the various statistical models based on the Haseman-Elston regression model. Our numerical studies demonstrated that susceptibility loci could be detected well by modeling the dispersion parameter appropriately. In particular, the HGLM had better performance than the linear regression model and the ordinary linear mixed model when the SNR is low, i.e., when substantial noise was present in the data. The study shows that the HGLM in combination with dispersion modeling can be utilized to identify multiple markers showing linkage to familial complex traits accurately. Appropriate dispersion modeling might be more powerful to identify markers closest to the major genes which determine a quantitative trait. © 2015 S. Karger AG, Basel.

  17. A heteroscedastic generalized linear model with a non-normal speed factor for responses and response times.

    Science.gov (United States)

    Molenaar, Dylan; Bolsinova, Maria

    2017-05-01

    In generalized linear modelling of responses and response times, the observed response time variables are commonly transformed to make their distribution approximately normal. A normal distribution for the transformed response times is desirable as it justifies the linearity and homoscedasticity assumptions in the underlying linear model. Past research has, however, shown that the transformed response times are not always normal. Models have been developed to accommodate this violation. In the present study, we propose a modelling approach for responses and response times to test and model non-normality in the transformed response times. Most importantly, we distinguish between non-normality due to heteroscedastic residual variances, and non-normality due to a skewed speed factor. In a simulation study, we establish parameter recovery and the power to separate both effects. In addition, we apply the model to a real data set. © 2017 The Authors. British Journal of Mathematical and Statistical Psychology published by John Wiley & Sons Ltd on behalf of British Psychological Society.

  18. Modeling the frequency of opposing left-turn conflicts at signalized intersections using generalized linear regression models.

    Science.gov (United States)

    Zhang, Xin; Liu, Pan; Chen, Yuguang; Bai, Lu; Wang, Wei

    2014-01-01

    The primary objective of this study was to identify whether the frequency of traffic conflicts at signalized intersections can be modeled. The opposing left-turn conflicts were selected for the development of conflict predictive models. Using data collected at 30 approaches at 20 signalized intersections, the underlying distributions of the conflicts under different traffic conditions were examined. Different conflict-predictive models were developed to relate the frequency of opposing left-turn conflicts to various explanatory variables. The models considered include a linear regression model, a negative binomial model, and separate models developed for four traffic scenarios. The prediction performance of different models was compared. The frequency of traffic conflicts follows a negative binominal distribution. The linear regression model is not appropriate for the conflict frequency data. In addition, drivers behaved differently under different traffic conditions. Accordingly, the effects of conflicting traffic volumes on conflict frequency vary across different traffic conditions. The occurrences of traffic conflicts at signalized intersections can be modeled using generalized linear regression models. The use of conflict predictive models has potential to expand the uses of surrogate safety measures in safety estimation and evaluation.

  19. FUSED KERNEL-SPLINE SMOOTHING FOR REPEATEDLY MEASURED OUTCOMES IN A GENERALIZED PARTIALLY LINEAR MODEL WITH FUNCTIONAL SINGLE INDEX.

    Science.gov (United States)

    Jiang, Fei; Ma, Yanyuan; Wang, Yuanjia

    We propose a generalized partially linear functional single index risk score model for repeatedly measured outcomes where the index itself is a function of time. We fuse the nonparametric kernel method and regression spline method, and modify the generalized estimating equation to facilitate estimation and inference. We use local smoothing kernel to estimate the unspecified coefficient functions of time, and use B-splines to estimate the unspecified function of the single index component. The covariance structure is taken into account via a working model, which provides valid estimation and inference procedure whether or not it captures the true covariance. The estimation method is applicable to both continuous and discrete outcomes. We derive large sample properties of the estimation procedure and show different convergence rate of each component of the model. The asymptotic properties when the kernel and regression spline methods are combined in a nested fashion has not been studied prior to this work even in the independent data case.

  20. Examining the Relationships between Watershed Urban Land Use and Stream Water Quality Using Linear and Generalized Additive Models

    Directory of Open Access Journals (Sweden)

    Sun-Ah Hwang

    2016-04-01

    Full Text Available Although close relationships between the water quality of streams and the types of land use within their watersheds have been well-documented in previous studies, many aspects of these relationships remain unclear. We examined the relationships between urban land use and water quality using data collected from 527 sample points in five major rivers in Korea—the Han, Geum, Nakdong, Younsan, and Seomjin Rivers. Water quality data were derived from samples collected and analyzed under the guidelines of the Korean National Aquatic Ecological Monitoring Program, and land use was quantified using products provided by the Korean Ministry of the Environment, which were used to create a Geographic Information System. Linear models (LMs and generalized additive models were developed to describe the relationships between urban land use and stream water quality, including biological oxygen demand (BOD, total nitrogen (TN, and total phosphorous (TP. A comparison between LMs and non-linear models (in terms of R2 and Akaike’s information criterion values indicated that the general additive models had a better fit and suggested a non-linear relationship between urban land use and water quality. Non-linear models for BOD, TN, and TP showed that each parameter had a similar relationship with urban land use, which had two breakpoints. The non-linear models suggested that the relationships between urban land use and water quality could be categorized into three regions, based on the proportion of urban land use. In moderate urban land use conditions, negative impacts of urban land use on water quality were observed, which confirmed the findings of previous studies. However, the relationships were different in very low urbanization or very high urbanization conditions. Our results could be used to develop strategies for more efficient stream restoration and management, which would enhance water quality based on the degree of urbanization in watersheds. In

  1. Examining secular trends and seasonality in count data using dynamic generalized linear modelling: a new methodological approach illustrated with hospital discharge data on myocardial infarction

    DEFF Research Database (Denmark)

    Lundbye-Christensen, Søren; Dethlefsen, Claus; Gorst-Rasmussen, Anders

    2009-01-01

    Time series of incidence counts often show secular trends and seasonal patterns. We present a model for incidence counts capable of handling a possible gradual change in growth rates and seasonal patterns, serial correlation, and overdispersion. The model resembles an ordinary time series...... regression model for Poisson counts. It differs in allowing the regression coefficients to vary gradually over time in a random fashion. During the 1983-1999 period, 17,989 incidents of acute myocardial infarction were recorded in the Hospital Discharge Registry for the county of North Jutland, Denmark....... Records were updated daily. A dynamic model with a seasonal pattern and an approximately linear trend was fitted to the data, and diagnostic plots indicated a good model fit. The analysis conducted with the dynamic model revealed peaks coinciding with above-average influenza A activity. On average...

  2. Generalized Confidence Intervals for Intra- and Inter-subject Coefficients of Variation in Linear Mixed-effects Models.

    Science.gov (United States)

    Forkman, Johannes

    2017-06-15

    Linear mixed-effects models are linear models with several variance components. Models with a single random-effects factor have two variance components: the random-effects variance, i. e., the inter-subject variance, and the residual error variance, i. e., the intra-subject variance. In many applications, it is practice to report variance components as coefficients of variation. The intra- and inter-subject coefficients of variation are the square roots of the corresponding variances divided by the mean. This article proposes methods for computing confidence intervals for intra- and inter-subject coefficients of variation using generalized pivotal quantities. The methods are illustrated through two examples. In the first example, precision is assessed within and between runs in a bioanalytical method validation. In the second example, variation is estimated within and between main plots in an agricultural split-plot experiment. Coverage of generalized confidence intervals is investigated through simulation and shown to be close to the nominal value.

  3. Application of a generalized linear mixed model to analyze mixture toxicity: survival of brown trout affected by copper and zinc.

    Science.gov (United States)

    Iwasaki, Yuichi; Brinkman, Stephen F

    2015-04-01

    Increased concerns about the toxicity of chemical mixtures have led to greater emphasis on analyzing the interactions among the mixture components based on observed effects. The authors applied a generalized linear mixed model (GLMM) to analyze survival of brown trout (Salmo trutta) acutely exposed to metal mixtures that contained copper and zinc. Compared with dominant conventional approaches based on an assumption of concentration addition and the concentration of a chemical that causes x% effect (ECx), the GLMM approach has 2 major advantages. First, binary response variables such as survival can be modeled without any transformations, and thus sample size can be taken into consideration. Second, the importance of the chemical interaction can be tested in a simple statistical manner. Through this application, the authors investigated whether the estimated concentration of the 2 metals binding to humic acid, which is assumed to be a proxy of nonspecific biotic ligand sites, provided a better prediction of survival effects than dissolved and free-ion concentrations of metals. The results suggest that the estimated concentration of metals binding to humic acid is a better predictor of survival effects, and thus the metal competition at the ligands could be an important mechanism responsible for effects of metal mixtures. Application of the GLMM (and the generalized linear model) presents an alternative or complementary approach to analyzing mixture toxicity. © 2015 SETAC.

  4. Mediation analysis when a continuous mediator is measured with error and the outcome follows a generalized linear model.

    Science.gov (United States)

    Valeri, Linda; Lin, Xihong; VanderWeele, Tyler J

    2014-12-10

    Mediation analysis is a popular approach to examine the extent to which the effect of an exposure on an outcome is through an intermediate variable (mediator) and the extent to which the effect is direct. When the mediator is mis-measured, the validity of mediation analysis can be severely undermined. In this paper, we first study the bias of classical, non-differential measurement error on a continuous mediator in the estimation of direct and indirect causal effects in generalized linear models when the outcome is either continuous or discrete and exposure-mediator interaction may be present. Our theoretical results as well as a numerical study demonstrate that in the presence of non-linearities, the bias of naive estimators for direct and indirect effects that ignore measurement error can take unintuitive directions. We then develop methods to correct for measurement error. Three correction approaches using method of moments, regression calibration, and SIMEX are compared. We apply the proposed method to the Massachusetts General Hospital lung cancer study to evaluate the effect of genetic variants mediated through smoking on lung cancer risk. Copyright © 2014 John Wiley & Sons, Ltd.

  5. A generalized fuzzy credibility-constrained linear fractional programming approach for optimal irrigation water allocation under uncertainty

    Science.gov (United States)

    Zhang, Chenglong; Guo, Ping

    2017-10-01

    The vague and fuzzy parametric information is a challenging issue in irrigation water management problems. In response to this problem, a generalized fuzzy credibility-constrained linear fractional programming (GFCCFP) model is developed for optimal irrigation water allocation under uncertainty. The model can be derived from integrating generalized fuzzy credibility-constrained programming (GFCCP) into a linear fractional programming (LFP) optimization framework. Therefore, it can solve ratio optimization problems associated with fuzzy parameters, and examine the variation of results under different credibility levels and weight coefficients of possibility and necessary. It has advantages in: (1) balancing the economic and resources objectives directly; (2) analyzing system efficiency; (3) generating more flexible decision solutions by giving different credibility levels and weight coefficients of possibility and (4) supporting in-depth analysis of the interrelationships among system efficiency, credibility level and weight coefficient. The model is applied to a case study of irrigation water allocation in the middle reaches of Heihe River Basin, northwest China. Therefore, optimal irrigation water allocation solutions from the GFCCFP model can be obtained. Moreover, factorial analysis on the two parameters (i.e. λ and γ) indicates that the weight coefficient is a main factor compared with credibility level for system efficiency. These results can be effective for support reasonable irrigation water resources management and agricultural production.

  6. General expressions for R1ρ relaxation for N-site chemical exchange and the special case of linear chains.

    Science.gov (United States)

    Koss, Hans; Rance, Mark; Palmer, Arthur G

    2017-01-01

    Exploration of dynamic processes in proteins and nucleic acids by spin-locking NMR experiments has been facilitated by the development of theoretical expressions for the R 1 ρ relaxation rate constant covering a variety of kinetic situations. Herein, we present a generalized approximation to the chemical exchange, R ex , component of R 1 ρ for arbitrary kinetic schemes, assuming the presence of a dominant major site population, derived from the negative reciprocal trace of the inverse Bloch-McConnell evolution matrix. This approximation is equivalent to first-order truncation of the characteristic polynomial derived from the Bloch-McConnell evolution matrix. For three- and four-site chemical exchange, the first-order approximations are sufficient to distinguish different kinetic schemes. We also introduce an approach to calculate R 1 ρ for linear N-site schemes, using the matrix determinant lemma to reduce the corresponding 3N×3N Bloch-McConnell evolution matrix to a 3×3 matrix. The first- and second order-expansions of the determinant of this 3×3 matrix are closely related to previously derived equations for two-site exchange. The second-order approximations for linear N-site schemes can be used to obtain more accurate approximations for non-linear N-site schemes, such as triangular three-site or star four-site topologies. The expressions presented herein provide powerful means for the estimation of R ex contributions for both low (CEST-limit) and high (R 1 ρ -limit) radiofrequency field strengths, provided that the population of one state is dominant. The general nature of the new expressions allows for consideration of complex kinetic situations in the analysis of NMR spin relaxation data. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Constructions and classifications of projective Poisson varieties

    Science.gov (United States)

    Pym, Brent

    2018-03-01

    This paper is intended both as an introduction to the algebraic geometry of holomorphic Poisson brackets, and as a survey of results on the classification of projective Poisson manifolds that have been obtained in the past 20 years. It is based on the lecture series delivered by the author at the Poisson 2016 Summer School in Geneva. The paper begins with a detailed treatment of Poisson surfaces, including adjunction, ruled surfaces and blowups, and leading to a statement of the full birational classification. We then describe several constructions of Poisson threefolds, outlining the classification in the regular case, and the case of rank-one Fano threefolds (such as projective space). Following a brief introduction to the notion of Poisson subspaces, we discuss Bondal's conjecture on the dimensions of degeneracy loci on Poisson Fano manifolds. We close with a discussion of log symplectic manifolds with simple normal crossings degeneracy divisor, including a new proof of the classification in the case of rank-one Fano manifolds.

  8. Solution of the Dirichlet Problem for the Poisson's Equation in a Multidimensional Infinite Layer

    Directory of Open Access Journals (Sweden)

    O. D. Algazin

    2015-01-01

    Full Text Available The paper considers the multidimensional Poisson equation in the domain bounded by two parallel hyperplanes (in the multidimensional infinite layer. For an n-dimensional half-space method of solving boundary value problems for linear partial differential equations with constant coefficients is a Fourier transform to the variables in the boundary hyperplane. The same method can be used for an infinite layer, as is done in this paper in the case of the Dirichlet problem for the Poisson equation. For strip and infinite layer in three-dimensional space the solutions of this problem are known. And in the three-dimensional case Green's function is written as an infinite series. In this paper, the solution is obtained in the integral form and kernels of integrals are expressed in a finite form in terms of elementary functions and Bessel functions. A recurrence relation between the kernels of integrals for n-dimensional and (n + 2 -dimensional layers was obtained. In particular, is built the Green's function of the Laplace operator for the Dirichlet problem, through which the solution of the problem is recorded. Even in three-dimensional case we obtained new formula compared to the known. It is shown that the kernel of the integral representation of the solution of the Dirichlet problem for a homogeneous Poisson equation (Laplace equation is an approximate identity (δ-shaped system of functions. Therefore, if the boundary values are generalized functions of slow growth, the solution of the Dirichlet problem for the homogeneous equation (Laplace is written as a convolution of kernels with these functions.

  9. Poisson's ratio and Young's modulus of lipid bilayers in different phases

    Directory of Open Access Journals (Sweden)

    Tayebeh eJadidi

    2014-04-01

    Full Text Available A general computational method is introduced to estimate the Poisson's ratio for membranes with small thickness.In this method, the Poisson's ratio is calculated by utilizing a rescaling of inter-particle distancesin one lateral direction under periodic boundary conditions. As an example for the coarse grained lipid model introduced by Lenz and Schmid, we calculate the Poisson's ratio in the gel, fluid, and interdigitated phases. Having the Poisson's ratio, enable us to obtain the Young's modulus for the membranes in different phases. The approach may be applied to other membranes such as graphene and tethered membranes in orderto predict the temperature dependence of its Poisson's ratio and Young's modulus.

  10. Modelling female fertility traits in beef cattle using linear and non-linear models.

    Science.gov (United States)

    Naya, H; Peñagaricano, F; Urioste, J I

    2017-06-01

    Female fertility traits are key components of the profitability of beef cattle production. However, these traits are difficult and expensive to measure, particularly under extensive pastoral conditions, and consequently, fertility records are in general scarce and somehow incomplete. Moreover, fertility traits are usually dominated by the effects of herd-year environment, and it is generally assumed that relatively small margins are kept for genetic improvement. New ways of modelling genetic variation in these traits are needed. Inspired in the methodological developments made by Prof. Daniel Gianola and co-workers, we assayed linear (Gaussian), Poisson, probit (threshold), censored Poisson and censored Gaussian models to three different kinds of endpoints, namely calving success (CS), number of days from first calving (CD) and number of failed oestrus (FE). For models involving FE and CS, non-linear models overperformed their linear counterparts. For models derived from CD, linear versions displayed better adjustment than the non-linear counterparts. Non-linear models showed consistently higher estimates of heritability and repeatability in all cases (h 2  linear models; h 2  > 0.23 and r > 0.24, for non-linear models). While additive and permanent environment effects showed highly favourable correlations between all models (>0.789), consistency in selecting the 10% best sires showed important differences, mainly amongst the considered endpoints (FE, CS and CD). In consequence, endpoints should be considered as modelling different underlying genetic effects, with linear models more appropriate to describe CD and non-linear models better for FE and CS. © 2017 Blackwell Verlag GmbH.

  11. Stochastic Averaging of Strongly Nonlinear Oscillators under Poisson White Noise Excitation

    Science.gov (United States)

    Zeng, Y.; Zhu, W. Q.

    A stochastic averaging method for single-degree-of-freedom (SDOF) strongly nonlinear oscillators under Poisson white noise excitation is proposed by using the so-called generalized harmonic functions. The stationary averaged generalized Fokker-Planck-Kolmogorov (GFPK) equation is solved by using the classical perturbation method. Then the procedure is applied to estimate the stationary probability density of response of a Duffing-van der Pol oscillator under Poisson white noise excitation. Theoretical results agree well with Monte Carlo simulations.

  12. A hybrid sampler for Poisson-Kingman mixture models

    OpenAIRE

    Lomeli, M.; Favaro, S.; Teh, Y. W.

    2015-01-01

    This paper concerns the introduction of a new Markov Chain Monte Carlo scheme for posterior sampling in Bayesian nonparametric mixture models with priors that belong to the general Poisson-Kingman class. We present a novel compact way of representing the infinite dimensional component of the model such that while explicitly representing this infinite component it has less memory and storage requirements than previous MCMC schemes. We describe comparative simulation results demonstrating the e...

  13. Solving (2 + 1)-dimensional sine-Poisson equation by a modified variable separated ordinary differential equation method

    International Nuclear Information System (INIS)

    Ka-Lin, Su; Yuan-Xi, Xie

    2010-01-01

    By introducing a more general auxiliary ordinary differential equation (ODE), a modified variable separated ordinary differential equation method is presented for solving the (2 + 1)-dimensional sine-Poisson equation. As a result, many explicit and exact solutions of the (2 + 1)-dimensional sine-Poisson equation are derived in a simple manner by this technique. (general)

  14. Poisson traces, D-modules, and symplectic resolutions

    Science.gov (United States)

    Etingof, Pavel; Schedler, Travis

    2018-03-01

    We survey the theory of Poisson traces (or zeroth Poisson homology) developed by the authors in a series of recent papers. The goal is to understand this subtle invariant of (singular) Poisson varieties, conditions for it to be finite-dimensional, its relationship to the geometry and topology of symplectic resolutions, and its applications to quantizations. The main technique is the study of a canonical D-module on the variety. In the case the variety has finitely many symplectic leaves (such as for symplectic singularities and Hamiltonian reductions of symplectic vector spaces by reductive groups), the D-module is holonomic, and hence, the space of Poisson traces is finite-dimensional. As an application, there are finitely many irreducible finite-dimensional representations of every quantization of the variety. Conjecturally, the D-module is the pushforward of the canonical D-module under every symplectic resolution of singularities, which implies that the space of Poisson traces is dual to the top cohomology of the resolution. We explain many examples where the conjecture is proved, such as symmetric powers of du Val singularities and symplectic surfaces and Slodowy slices in the nilpotent cone of a semisimple Lie algebra. We compute the D-module in the case of surfaces with isolated singularities and show it is not always semisimple. We also explain generalizations to arbitrary Lie algebras of vector fields, connections to the Bernstein-Sato polynomial, relations to two-variable special polynomials such as Kostka polynomials and Tutte polynomials, and a conjectural relationship with deformations of symplectic resolutions. In the appendix we give a brief recollection of the theory of D-modules on singular varieties that we require.

  15. The Poisson equation on Klein surfaces

    Directory of Open Access Journals (Sweden)

    Monica Rosiu

    2016-04-01

    Full Text Available We obtain a formula for the solution of the Poisson equation with Dirichlet boundary condition on a region of a Klein surface. This formula reveals the symmetric character of the solution.

  16. Poisson point processes imaging, tracking, and sensing

    CERN Document Server

    Streit, Roy L

    2010-01-01

    This overview of non-homogeneous and multidimensional Poisson point processes and their applications features mathematical tools and applications from emission- and transmission-computed tomography to multiple target tracking and distributed sensor detection.

  17. Nonlinear recurrent neural networks for finite-time solution of general time-varying linear matrix equations.

    Science.gov (United States)

    Xiao, Lin; Liao, Bolin; Li, Shuai; Chen, Ke

    2018-02-01

    In order to solve general time-varying linear matrix equations (LMEs) more efficiently, this paper proposes two nonlinear recurrent neural networks based on two nonlinear activation functions. According to Lyapunov theory, such two nonlinear recurrent neural networks are proved to be convergent within finite-time. Besides, by solving differential equation, the upper bounds of the finite convergence time are determined analytically. Compared with existing recurrent neural networks, the proposed two nonlinear recurrent neural networks have a better convergence property (i.e., the upper bound is lower), and thus the accurate solutions of general time-varying LMEs can be obtained with less time. At last, various different situations have been considered by setting different coefficient matrices of general time-varying LMEs and a great variety of computer simulations (including the application to robot manipulators) have been conducted to validate the better finite-time convergence of the proposed two nonlinear recurrent neural networks. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. Optimal smoothing of poisson degraded nuclear medicine image data

    International Nuclear Information System (INIS)

    Hull, D.M.

    1985-01-01

    The development of a method that removes Poisson noise from nuclear medicine studies will have significant impact on the quantitative analysis and clinical reliability of these data. The primary objective of the work described in this thesis was to develop a linear, non-stationary optimal filter to reduce Poisson noise. The derived filter is automatically calculated from a large group (library) of similar patient studies representing all similarly acquired studies (the ensemble). The filter design was evaluated under controlled conditions using two computer simulated ensembles, devised to represent selected properties of real patient gated blood pool studies. Fortran programs were developed to generate libraries of Poisson degraded simulated studies for each ensemble. These libraries then were used to estimate optimal filters specific to the ensemble. Libraries of previously acquired patient gated blood pool studies then were used to estimate the optimal filters for an ensemble of similarly acquired gated blood pool studies. These filters were applied to studies of 13 patients who received multiple repeat studies at one time. Comparisons of both the filtered and raw data to averages of the repeat studies demonstrated that the optimal filters, calculated from a library of 800 studies, reduce the mean square error in the patient data by 60%. It is expected that optimally filtered gated blood pool studies will improve quantitative analysis of the data

  19. Blind beam-hardening correction from Poisson measurements

    Science.gov (United States)

    Gu, Renliang; Dogandžić, Aleksandar

    2016-02-01

    We develop a sparse image reconstruction method for Poisson-distributed polychromatic X-ray computed tomography (CT) measurements under the blind scenario where the material of the inspected object and the incident energy spectrum are unknown. We employ our mass-attenuation spectrum parameterization of the noiseless measurements and express the mass- attenuation spectrum as a linear combination of B-spline basis functions of order one. A block coordinate-descent algorithm is developed for constrained minimization of a penalized Poisson negative log-likelihood (NLL) cost function, where constraints and penalty terms ensure nonnegativity of the spline coefficients and nonnegativity and sparsity of the density map image; the image sparsity is imposed using a convex total-variation (TV) norm penalty term. This algorithm alternates between a Nesterov's proximal-gradient (NPG) step for estimating the density map image and a limited-memory Broyden-Fletcher-Goldfarb-Shanno with box constraints (L-BFGS-B) step for estimating the incident-spectrum parameters. To accelerate convergence of the density- map NPG steps, we apply function restart and a step-size selection scheme that accounts for varying local Lipschitz constants of the Poisson NLL. Real X-ray CT reconstruction examples demonstrate the performance of the proposed scheme.

  20. A new and general approach to signal denoising and eye movement classification based on segmented linear regression.

    Science.gov (United States)

    Pekkanen, Jami; Lappi, Otto

    2017-12-18

    We introduce a conceptually novel method for eye-movement signal analysis. The method is general in that it does not place severe restrictions on sampling frequency, measurement noise or subject behavior. Event identification is based on segmentation that simultaneously denoises the signal and determines event boundaries. The full gaze position time-series is segmented into an approximately optimal piecewise linear function in O(n) time. Gaze feature parameters for classification into fixations, saccades, smooth pursuits and post-saccadic oscillations are derived from human labeling in a data-driven manner. The range of oculomotor events identified and the powerful denoising performance make the method useable for both low-noise controlled laboratory settings and high-noise complex field experiments. This is desirable for harmonizing the gaze behavior (in the wild) and oculomotor event identification (in the laboratory) approaches to eye movement behavior. Denoising and classification performance are assessed using multiple datasets. Full open source implementation is included.

  1. Two-step algorithm of generalized PAPA method applied to linear programming solution of dynamic matrix control

    International Nuclear Information System (INIS)

    Shimizu, Yoshiaki

    1991-01-01

    In recent complicated nuclear systems, there are increasing demands for developing highly advanced procedures for various problems-solvings. Among them keen interests have been paid on man-machine communications to improve both safety and economy factors. Many optimization methods have been good enough to elaborate on these points. In this preliminary note, we will concern with application of linear programming (LP) for this purpose. First we will present a new superior version of the generalized PAPA method (GEPAPA) to solve LP problems. We will then examine its effectiveness when applied to derive dynamic matrix control (DMC) as the LP solution. The approach is to aim at the above goal through a quality control of process that will appear in the system. (author)

  2. PWR in-core nuclear fuel management optimization utilizing nodal (non-linear NEM) generalized perturbation theory

    International Nuclear Information System (INIS)

    Maldonado, G.I.; Turinsky, P.J.; Kropaczek, D.J.

    1993-01-01

    The computational capability of efficiently and accurately evaluate reactor core attributes (i.e., k eff and power distributions as a function of cycle burnup) utilizing a second-order accurate advanced nodal Generalized Perturbation Theory (GPT) model has been developed. The GPT model is derived from the forward non-linear iterative Nodal Expansion Method (NEM) strategy, thereby extending its inherent savings in memory storage and high computational efficiency to also encompass GPT via the preservation of the finite-difference matrix structure. The above development was easily implemented into the existing coarse-mesh finite-difference GPT-based in-core fuel management optimization code FORMOSA-P, thus combining the proven robustness of its adaptive Simulated Annealing (SA) multiple-objective optimization algorithm with a high-fidelity NEM GPT neutronics model to produce a powerful computational tool used to generate families of near-optimum loading patterns for PWRs. (orig.)

  3. A re-formulation of generalized linear mixed models to fit family data in genetic association studies

    Directory of Open Access Journals (Sweden)

    Tao eWang

    2015-03-01

    Full Text Available The generalized linear mixed model (GLMM is a useful tool for modeling genetic correlation among family data in genetic association studies. However, when dealing with families of varied sizes and diverse genetic relatedness, the GLMM has a special correlation structure which often makes it difficult to be specified using standard statistical software. In this study, we propose a Cholesky decomposition based re-formulation of the GLMM so that the re-formulated GLMM can be specified conveniently via `proc nlmixed' and `proc glimmix' in SAS, or OpenBUGS via R package BRugs. Performances of these procedures in fitting the re-formulated GLMM are examined through simulation studies. We also apply this re-formulated GLMM to analyze a real data set from Type 1 Diabetes Genetics Consortium (T1DGC.

  4. Variable selection in Bayesian generalized linear-mixed models: an illustration using candidate gene case-control association studies.

    Science.gov (United States)

    Tsai, Miao-Yu

    2015-03-01

    The problem of variable selection in the generalized linear-mixed models (GLMMs) is pervasive in statistical practice. For the purpose of variable selection, many methodologies for determining the best subset of explanatory variables currently exist according to the model complexity and differences between applications. In this paper, we develop a "higher posterior probability model with bootstrap" (HPMB) approach to select explanatory variables without fitting all possible GLMMs involving a small or moderate number of explanatory variables. Furthermore, to save computational load, we propose an efficient approximation approach with Laplace's method and Taylor's expansion to approximate intractable integrals in GLMMs. Simulation studies and an application of HapMap data provide evidence that this selection approach is computationally feasible and reliable for exploring true candidate genes and gene-gene associations, after adjusting for complex structures among clusters. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Bayesian inference for generalized linear mixed model based on the multivariate t distribution in population pharmacokinetic study.

    Science.gov (United States)

    Yan, Fang-Rong; Huang, Yuan; Liu, Jun-Lin; Lu, Tao; Lin, Jin-Guan

    2013-01-01

    This article provides a fully bayesian approach for modeling of single-dose and complete pharmacokinetic data in a population pharmacokinetic (PK) model. To overcome the impact of outliers and the difficulty of computation, a generalized linear model is chosen with the hypothesis that the errors follow a multivariate Student t distribution which is a heavy-tailed distribution. The aim of this study is to investigate and implement the performance of the multivariate t distribution to analyze population pharmacokinetic data. Bayesian predictive inferences and the Metropolis-Hastings algorithm schemes are used to process the intractable posterior integration. The precision and accuracy of the proposed model are illustrated by the simulating data and a real example of theophylline data.

  6. A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer's Disease.

    Science.gov (United States)

    Wang, Xulong; Philip, Vivek M; Ananda, Guruprasad; White, Charles C; Malhotra, Ankit; Michalski, Paul J; Karuturi, Krishna R Murthy; Chintalapudi, Sumana R; Acklin, Casey; Sasner, Michael; Bennett, David A; De Jager, Philip L; Howell, Gareth R; Carter, Gregory W

    2018-03-05

    Recent technical and methodological advances have greatly enhanced genome-wide association studies (GWAS). The advent of low-cost whole-genome sequencing facilitates high-resolution variant identification, and the development of linear mixed models (LMM) allows improved identification of putatively causal variants. While essential for correcting false positive associations due to sample relatedness and population stratification, LMMs have commonly been restricted to quantitative variables. However, phenotypic traits in association studies are often categorical, coded as binary case-control or ordered variables describing disease stages. To address these issues, we have devised a method for genomic association studies that implements a generalized linear mixed model (GLMM) in a Bayesian framework, called Bayes-GLMM Bayes-GLMM has four major features: (1) support of categorical, binary and quantitative variables; (2) cohesive integration of previous GWAS results for related traits; (3) correction for sample relatedness by mixed modeling; and (4) model estimation by both Markov chain Monte Carlo (MCMC) sampling and maximal likelihood estimation. We applied Bayes-GLMM to the whole-genome sequencing cohort of the Alzheimer's Disease Sequencing Project (ADSP). This study contains 570 individuals from 111 families, each with Alzheimer's disease diagnosed at one of four confidence levels. With Bayes-GLMM we identified four variants in three loci significantly associated with Alzheimer's disease. Two variants, rs140233081 and rs149372995 lie between PRKAR1B and PDGFA The coded proteins are localized to the glial-vascular unit, and PDGFA transcript levels are associated with AD-related neuropathology. In summary, this work provides implementation of a flexible, generalized mixed model approach in a Bayesian framework for association studies. Copyright © 2018, Genetics.

  7. Spatial and Temporal Distribution of Plasmodium vivax Malaria in Korea Estimated with a Hierarchical Generalized Linear Model.

    Science.gov (United States)

    Noh, Maengseok; Lee, Youngjo; Oh, Seungyoung; Chu, Chaeshin; Gwack, Jin; Youn, Seung-Ki; Cho, Shin Hyeong; Lee, Won Ja; Huh, Sun

    2012-12-01

    The spatial and temporal correlations were estimated to determine Plasmodium vivax malarial transmission pattern in Korea from 2001-2011 with the hierarchical generalized linear model. Malaria cases reported to the Korea Centers for Disease Control and Prevention from 2001 to 2011 were analyzed with descriptive statistics and the incidence was estimated according to age, sex, and year by the hierarchical generalized linear model. Spatial and temporal correlation was estimated and the best model was selected from nine models. Results were presented as diseases map according to age and sex. The incidence according to age was highest in the 20-25-year-old group (244.52 infections/100,000). Mean ages of infected males and females were 31.0 years and 45.3 years with incidences 7.8 infections/100,000 and 7.1 infections/100,000 after estimation. The mean month for infection was mid-July with incidence 10.4 infections/100,000. The best-fit model showed that there was a spatial and temporal correlation in the malarial transmission. Incidence was very low or negligible in areas distant from the demilitarized zone between Republic of Korea and Democratic People's Republic of Korea (North Korea) if the 20-29-year-old male group was omitted in the diseases map. Malarial transmission in a region in Korea was influenced by the incidence in adjacent regions in recent years. Since malaria in Korea mainly originates from mosquitoes from North Korea, there will be continuous decrease if there is no further outbreak in North Korea.

  8. The Hamiltonian structure of general relativistic perfect fluids

    International Nuclear Information System (INIS)

    Bao, D.; Houston Univ., TX; Marsden, J.; Walton, R.

    1985-01-01

    We show that the evolution equations for a perfect fluid coupled to general relativity in a general lapse and shift, are Hamiltonian relative to a certain Poisson structure. For the fluid variables, a Lie-Poisson structure associated to the dual of a semi-direct product Lie algebra is used, while the bracket for the gravitational variables has the usual canonical symplectic structure. The evolution is governed by a Hamiltonian which is equivalent to that obtained from a canonical analysis. The relationship of our Hamiltonian structure with other approaches in the literature, such as Clebsch potentials, Lagrangian to Eulerian transformations, and its use in clarifying linearization stability, are discussed. (orig.)

  9. Supersymmetric quantum corrections and Poisson-Lie T-duality

    International Nuclear Information System (INIS)

    Assaoui, F.; Lhallabi, T.; Abdus Salam International Centre for Theoretical Physics, Trieste

    2000-07-01

    The quantum actions of the (4,4) supersymmetric non-linear sigma model and its dual in the Abelian case are constructed by using the background superfield method. The propagators of the quantum superfield and its dual and the gauge fixing actions of the original and dual (4,4) supersymmetric sigma models are determined. On the other hand, the BRST transformations are used to obtain the quantum dual action of the (4,4) supersymmetric nonlinear sigma model in the sense of Poisson-Lie T-duality. (author)

  10. Maslov indices, Poisson brackets, and singular differential forms

    Science.gov (United States)

    Esterlis, I.; Haggard, H. M.; Hedeman, A.; Littlejohn, R. G.

    2014-06-01

    Maslov indices are integers that appear in semiclassical wave functions and quantization conditions. They are often notoriously difficult to compute. We present methods of computing the Maslov index that rely only on typically elementary Poisson brackets and simple linear algebra. We also present a singular differential form, whose integral along a curve gives the Maslov index of that curve. The form is closed but not exact, and transforms by an exact differential under canonical transformations. We illustrate the method with the 6j-symbol, which is important in angular-momentum theory and in quantum gravity.

  11. Poisson versus threshold models for genetic analysis of clinical mastitis in US Holsteins.

    Science.gov (United States)

    Vazquez, A I; Weigel, K A; Gianola, D; Bates, D M; Perez-Cabal, M A; Rosa, G J M; Chang, Y M

    2009-10-01

    Typically, clinical mastitis is coded as the presence or absence of disease in a given lactation, and records are analyzed with either linear models or binary threshold models. Because the presence of mastitis may include cows with multiple episodes, there is a loss of information when counts are treated as binary responses. Poisson models are appropriated for random variables measured as the number of events, and although these models are used extensively in studying the epidemiology of mastitis, they have rarely been used for studying the genetic aspects of mastitis. Ordinal threshold models are pertinent for ordered categorical responses; although one can hypothesize that the number of clinical mastitis episodes per animal reflects a continuous underlying increase in mastitis susceptibility, these models have rarely been used in genetic analysis of mastitis. The objective of this study was to compare probit, Poisson, and ordinal threshold models for the genetic evaluation of US Holstein sires for clinical mastitis. Mastitis was measured as a binary trait or as the number of mastitis cases. Data from 44,908 first-parity cows recorded in on-farm herd management software were gathered, edited, and processed for the present study. The cows were daughters of 1,861 sires, distributed over 94 herds. Predictive ability was assessed via a 5-fold cross-validation using 2 loss functions: mean squared error of prediction (MSEP) as the end point and a cost difference function. The heritability estimates were 0.061 for mastitis measured as a binary trait in the probit model and 0.085 and 0.132 for the number of mastitis cases in the ordinal threshold and Poisson models, respectively; because of scale differences, only the probit and ordinal threshold models are directly comparable. Among healthy animals, MSEP was smallest for the probit model, and the cost function was smallest for the ordinal threshold model. Among diseased animals, MSEP and the cost function were smallest

  12. Filling of a Poisson trap by a population of random intermittent searchers

    KAUST Repository

    Bressloff, Paul C.

    2012-03-01

    We extend the continuum theory of random intermittent search processes to the case of N independent searchers looking to deliver cargo to a single hidden target located somewhere on a semi-infinite track. Each searcher randomly switches between a stationary state and either a leftward or rightward constant velocity state. We assume that all of the particles start at one end of the track and realize sample trajectories independently generated from the same underlying stochastic process. The hidden target is treated as a partially absorbing trap in which a particle can only detect the target and deliver its cargo if it is stationary and within range of the target; the particle is removed from the system after delivering its cargo. As a further generalization of previous models, we assume that up to n successive particles can find the target and deliver its cargo. Assuming that the rate of target detection scales as 1/N, we show that there exists a well-defined mean-field limit N→ in which the stochastic model reduces to a deterministic system of linear reaction-hyperbolic equations for the concentrations of particles in each of the internal states. These equations decouple from the stochastic process associated with filling the target with cargo. The latter can be modeled as a Poisson process in which the time-dependent rate of filling λ(t) depends on the concentration of stationary particles within the target domain. Hence, we refer to the target as a Poisson trap. We analyze the efficiency of filling the Poisson trap with n particles in terms of the waiting time density f n(t). The latter is determined by the integrated Poisson rate μ(t)=0tλ(s)ds, which in turn depends on the solution to the reaction-hyperbolic equations. We obtain an approximate solution for the particle concentrations by reducing the system of reaction-hyperbolic equations to a scalar advection-diffusion equation using a quasisteady-state analysis. We compare our analytical results for the

  13. A dictionary learning approach for Poisson image deblurring.

    Science.gov (United States)

    Ma, Liyan; Moisan, Lionel; Yu, Jian; Zeng, Tieyong

    2013-07-01

    The restoration of images corrupted by blur and Poisson noise is a key issue in medical and biological image processing. While most existing methods are based on variational models, generally derived from a maximum a posteriori (MAP) formulation, recently sparse representations of images have shown to be efficient approaches for image recovery. Following this idea, we propose in this paper a model containing three terms: a patch-based sparse representation prior over a learned dictionary, the pixel-based total variation regularization term and a data-fidelity term capturing the statistics of Poisson noise. The resulting optimization problem can be solved by an alternating minimization technique combined with variable splitting. Extensive experimental results suggest that in terms of visual quality, peak signal-to-noise ratio value and the method noise, the proposed algorithm outperforms state-of-the-art methods.

  14. Reference manual for the POISSON/SUPERFISH Group of Codes

    Energy Technology Data Exchange (ETDEWEB)

    1987-01-01

    The POISSON/SUPERFISH Group codes were set up to solve two separate problems: the design of magnets and the design of rf cavities in a two-dimensional geometry. The first stage of either problem is to describe the layout of the magnet or cavity in a way that can be used as input to solve the generalized Poisson equation for magnets or the Helmholtz equations for cavities. The computer codes require that the problems be discretized by replacing the differentials (dx,dy) by finite differences ({delta}X,{delta}Y). Instead of defining the function everywhere in a plane, the function is defined only at a finite number of points on a mesh in the plane.

  15. Bering's proposal for boundary contribution to the Poisson bracket

    International Nuclear Information System (INIS)

    Soloviev, V.O.

    1998-11-01

    It is shown that the Poisson bracket with boundary terms recently proposed by Bering can be deduced from the Poisson bracket proposed by the present author if one omits terms free of Euler-Lagrange derivatives (''annihilation principle''). This corresponds to another definition of the formal product of distributions (or, saying it in other words, to another definition of the pairing between 1-forms and 1-vectors in the formal variational calculus). We extend the formula initially suggested by Bering only for the ultralocal case with constant coefficients onto the general non-ultralocal brackets with coefficients depending on fields and their spatial derivatives. The lack of invariance under changes of dependent variables (field redefinitions) seems a drawback of this proposal. (author)

  16. Transferring Pre-Trained Deep CNNs for Remote Scene Classification with General Features Learned from Linear PCA Network

    Directory of Open Access Journals (Sweden)

    Jie Wang

    2017-03-01

    Full Text Available Deep convolutional neural networks (CNNs have been widely used to obtain high-level representation in various computer vision tasks. However, in the field of remote sensing, there are not sufficient images to train a useful deep CNN. Instead, we tend to transfer successful pre-trained deep CNNs to remote sensing tasks. In the transferring process, generalization power of features in pre-trained deep CNNs plays the key role. In this paper, we propose two promising architectures to extract general features from pre-trained deep CNNs for remote scene classification. These two architectures suggest two directions for improvement. First, before the pre-trained deep CNNs, we design a linear PCA network (LPCANet to synthesize spatial information of remote sensing images in each spectral channel. This design shortens the spatial “distance” of target and source datasets for pre-trained deep CNNs. Second, we introduce quaternion algebra to LPCANet, which further shortens the spectral “distance” between remote sensing images and images used to pre-train deep CNNs. With five well-known pre-trained deep CNNs, experimental results on three independent remote sensing datasets demonstrate that our proposed framework obtains state-of-the-art results without fine-tuning and feature fusing. This paper also provides baseline for transferring fresh pretrained deep CNNs to other remote sensing tasks.

  17. A unifying framework for robust association testing, estimation, and genetic model selection using the generalized linear model.

    Science.gov (United States)

    Loley, Christina; König, Inke R; Hothorn, Ludwig; Ziegler, Andreas

    2013-12-01

    The analysis of genome-wide genetic association studies generally starts with univariate statistical tests of each single-nucleotide polymorphism. The standard approach is the Cochran-Armitage trend test or its logistic regression equivalent although this approach can lose considerable power if the underlying genetic model is not additive. An alternative is the MAX test, which is robust against the three basic modes of inheritance. Here, the asymptotic distribution of the MAX test is derived using the generalized linear model together with the Delta method and multiple contrasts. The approach is applicable to binary, quantitative, and survival traits. It may be used for unrelated individuals, family-based studies, and matched pairs. The approach provides point and interval effect estimates and allows selecting the most plausible genetic model using the minimum P-value. R code is provided. A Monte-Carlo simulation study shows that the asymptotic MAX test framework meets type I error levels well, has good power, and good model selection properties for minor allele frequencies ≥0.3. Pearson's χ(2)-test is superior for lower minor allele frequencies with low frequencies for the rare homozygous genotype. In these cases, the model selection procedure should be used with caution. The use of the MAX test is illustrated by reanalyzing findings from seven genome-wide association studies including case-control, matched pairs, and quantitative trait data.

  18. Dirichlet forms methods for Poisson point measures and Lévy processes with emphasis on the creation-annihilation techniques

    CERN Document Server

    Bouleau, Nicolas

    2015-01-01

    A simplified approach to Malliavin calculus adapted to Poisson random measures is developed and applied in this book. Called the “lent particle method” it is based on perturbation of the position of particles. Poisson random measures describe phenomena involving random jumps (for instance in mathematical finance) or the random distribution of particles (as in statistical physics). Thanks to the theory of Dirichlet forms, the authors develop a mathematical tool for a quite general class of random Poisson measures and significantly simplify computations of Malliavin matrices of Poisson functionals. The method gives rise to a new explicit calculus that they illustrate on various examples: it consists in adding a particle and then removing it after computing the gradient. Using this method, one can establish absolute continuity of Poisson functionals such as Lévy areas, solutions of SDEs driven by Poisson measure and, by iteration, obtain regularity of laws. The authors also give applications to error calcul...

  19. Use of reflectance spectrophotometry and colorimetry in a general linear model for the determination of the age of bruises.

    Science.gov (United States)

    Hughes, Vanessa K; Langlois, Neil E I

    2010-12-01

    Bruises can have medicolegal significance such that the age of a bruise may be an important issue. This study sought to determine if colorimetry or reflectance spectrophotometry could be employed to objectively estimate the age of bruises. Based on a previously described method, reflectance spectrophotometric scans were obtained from bruises using a Cary 100 Bio spectrophotometer fitted with a fibre-optic reflectance probe. Measurements were taken from the bruise and a control area. Software was used to calculate the first derivative at 490 and 480 nm; the proportion of oxygenated hemoglobin was calculated using an isobestic point method and a software application converted the scan data into colorimetry data. In addition, data on factors that might be associated with the determination of the age of a bruise: subject age, subject sex, degree of trauma, bruise size, skin color, body build, and depth of bruise were recorded. From 147 subjects, 233 reflectance spectrophotometry scans were obtained for analysis. The age of the bruises ranged from 0.5 to 231.5 h. A General Linear Model analysis method was used. This revealed that colorimetric measurement of the yellowness of a bruise accounted for 13% of the bruise age. By incorporation of the other recorded data (as above), yellowness could predict up to 32% of the age of a bruise-implying that 68% of the variation was dependent on other factors. However, critical appraisal of the model revealed that the colorimetry method of determining the age of a bruise was affected by skin tone and required a measure of the proportion of oxygenated hemoglobin, which is obtained by spectrophotometric methods. Using spectrophotometry, the first derivative at 490 nm alone accounted for 18% of the bruise age estimate. When additional factors (subject sex, bruise depth and oxygenation of hemoglobin) were included in the General Linear Model this increased to 31%-implying that 69% of the variation was dependent on other factors. This

  20. Estimation of Poisson noise in spatial domain

    Science.gov (United States)

    Švihlík, Jan; Fliegel, Karel; Vítek, Stanislav; Kukal, Jaromír.; Krbcová, Zuzana

    2017-09-01

    This paper deals with modeling of astronomical images in the spatial domain. We consider astronomical light images contaminated by the dark current which is modeled by Poisson random process. Dark frame image maps the thermally generated charge of the CCD sensor. In this paper, we solve the problem of an addition of two Poisson random variables. At first, the noise analysis of images obtained from the astronomical camera is performed. It allows estimating parameters of the Poisson probability mass functions in every pixel of the acquired dark frame. Then the resulting distributions of the light image can be found. If the distributions of the light image pixels are identified, then the denoising algorithm can be applied. The performance of the Bayesian approach in the spatial domain is compared with the direct approach based on the method of moments and the dark frame subtraction.

  1. High order Poisson Solver for unbounded flows

    DEFF Research Database (Denmark)

    Hejlesen, Mads Mølholm; Rasmussen, Johannes Tophøj; Chatelain, Philippe

    2015-01-01

    This paper presents a high order method for solving the unbounded Poisson equation on a regular mesh using a Green’s function solution. The high order convergence was achieved by formulating mollified integration kernels, that were derived from a filter regularisation of the solution field...... the equations of fluid mechanics as an example, but can be used in many physical problems to solve the Poisson equation on a rectangular unbounded domain. For the two-dimensional case we propose an infinitely smooth test function which allows for arbitrary high order convergence. Using Gaussian smoothing....... The method was implemented on a rectangular domain using fast Fourier transforms (FFT) to increase computational efficiency. The Poisson solver was extended to directly solve the derivatives of the solution. This is achieved either by including the differential operator in the integration kernel...

  2. Selective Contrast Adjustment by Poisson Equation

    Directory of Open Access Journals (Sweden)

    Ana-Belen Petro

    2013-09-01

    Full Text Available Poisson Image Editing is a new technique permitting to modify the gradient vector field of an image, and then to recover an image with a gradient approaching this modified gradient field. This amounts to solve a Poisson equation, an operation which can be efficiently performed by Fast Fourier Transform (FFT. This paper describes an algorithm applying this technique, with two different variants. The first variant enhances the contrast by increasing the gradient in the dark regions of the image. This method is well adapted to images with back light or strong shadows, and reveals details in the shadows. The second variant of the same Poisson technique enhances all small gradients in the image, thus also sometimes revealing details and texture.

  3. Poisson regression for modeling count and frequency outcomes in trauma research.

    Science.gov (United States)

    Gagnon, David R; Doron-LaMarca, Susan; Bell, Margret; O'Farrell, Timothy J; Taft, Casey T

    2008-10-01

    The authors describe how the Poisson regression method for analyzing count or frequency outcome variables can be applied in trauma studies. The outcome of interest in trauma research may represent a count of the number of incidents of behavior occurring in a given time interval, such as acts of physical aggression or substance abuse. Traditional linear regression approaches assume a normally distributed outcome variable with equal variances over the range of predictor variables, and may not be optimal for modeling count outcomes. An application of Poisson regression is presented using data from a study of intimate partner aggression among male patients in an alcohol treatment program and their female partners. Results of Poisson regression and linear regression models are compared.

  4. Predicting the multi-domain progression of Parkinson's disease: a Bayesian multivariate generalized linear mixed-effect model.

    Science.gov (United States)

    Wang, Ming; Li, Zheng; Lee, Eun Young; Lewis, Mechelle M; Zhang, Lijun; Sterling, Nicholas W; Wagner, Daymond; Eslinger, Paul; Du, Guangwei; Huang, Xuemei

    2017-09-25

    It is challenging for current statistical models to predict clinical progression of Parkinson's disease (PD) because of the involvement of multi-domains and longitudinal data. Past univariate longitudinal or multivariate analyses from cross-sectional trials have limited power to predict individual outcomes or a single moment. The multivariate generalized linear mixed-effect model (GLMM) under the Bayesian framework was proposed to study multi-domain longitudinal outcomes obtained at baseline, 18-, and 36-month. The outcomes included motor, non-motor, and postural instability scores from the MDS-UPDRS, and demographic and standardized clinical data were utilized as covariates. The dynamic prediction was performed for both internal and external subjects using the samples from the posterior distributions of the parameter estimates and random effects, and also the predictive accuracy was evaluated based on the root of mean square error (RMSE), absolute bias (AB) and the area under the receiver operating characteristic (ROC) curve. First, our prediction model identified clinical data that were differentially associated with motor, non-motor, and postural stability scores. Second, the predictive accuracy of our model for the training data was assessed, and improved prediction was gained in particularly for non-motor (RMSE and AB: 2.89 and 2.20) compared to univariate analysis (RMSE and AB: 3.04 and 2.35). Third, the individual-level predictions of longitudinal trajectories for the testing data were performed, with ~80% observed values falling within the 95% credible intervals. Multivariate general mixed models hold promise to predict clinical progression of individual outcomes in PD. The data was obtained from Dr. Xuemei Huang's NIH grant R01 NS060722 , part of NINDS PD Biomarker Program (PDBP). All data was entered within 24 h of collection to the Data Management Repository (DMR), which is publically available ( https://pdbp.ninds.nih.gov/data-management ).

  5. Linear algebra

    CERN Document Server

    Said-Houari, Belkacem

    2017-01-01

    This self-contained, clearly written textbook on linear algebra is easily accessible for students. It begins with the simple linear equation and generalizes several notions from this equation for the system of linear equations and introduces the main ideas using matrices. It then offers a detailed chapter on determinants and introduces the main ideas with detailed proofs. The third chapter introduces the Euclidean spaces using very simple geometric ideas and discusses various major inequalities and identities. These ideas offer a solid basis for understanding general Hilbert spaces in functional analysis. The following two chapters address general vector spaces, including some rigorous proofs to all the main results, and linear transformation: areas that are ignored or are poorly explained in many textbooks. Chapter 6 introduces the idea of matrices using linear transformation, which is easier to understand than the usual theory of matrices approach. The final two chapters are more advanced, introducing t...

  6. SnIPRE: selection inference using a Poisson random effects model.

    Directory of Open Access Journals (Sweden)

    Kirsten E Eilertson

    Full Text Available We present an approach for identifying genes under natural selection using polymorphism and divergence data from synonymous and non-synonymous sites within genes. A generalized linear mixed model is used to model the genome-wide variability among categories of mutations and estimate its functional consequence. We demonstrate how the model's estimated fixed and random effects can be used to identify genes under selection. The parameter estimates from our generalized linear model can be transformed to yield population genetic parameter estimates for quantities including the average selection coefficient for new mutations at a locus, the synonymous and non-synynomous mutation rates, and species divergence times. Furthermore, our approach incorporates stochastic variation due to the evolutionary process and can be fit using standard statistical software. The model is fit in both the empirical Bayes and Bayesian settings using the lme4 package in R, and Markov chain Monte Carlo methods in WinBUGS. Using simulated data we compare our method to existing approaches for detecting genes under selection: the McDonald-Kreitman test, and two versions of the Poisson random field based method MKprf. Overall, we find our method universally outperforms existing methods for detecting genes subject to selection using polymorphism and divergence data.

  7. Generalized linear mixed model for binary outcomes when covariates are subject to measurement errors and detection limits.

    Science.gov (United States)

    Xie, Xianhong; Xue, Xiaonan; Strickler, Howard D

    2018-01-15

    Longitudinal measurement of biomarkers is important in determining risk factors for binary endpoints such as infection or disease. However, biomarkers are subject to measurement error, and some are also subject to left-censoring due to a lower limit of detection. Statistical methods to address these issues are few. We herein propose a generalized linear mixed model and estimate the model parameters using the Monte Carlo Newton-Raphson (MCNR) method. Inferences regarding the parameters are made by applying Louis's method and the delta method. Simulation studies were conducted to compare the proposed MCNR method with existing methods including the maximum likelihood (ML) method and the ad hoc approach of replacing the left-censored values with half of the detection limit (HDL). The results showed that the performance of the MCNR method is superior to ML and HDL with respect to the empirical standard error, as well as the coverage probability for the 95% confidence interval. The HDL method uses an incorrect imputation method, and the computation is constrained by the number of quadrature points; while the ML method also suffers from the constrain for the number of quadrature points, the MCNR method does not have this limitation and approximates the likelihood function better than the other methods. The improvement of the MCNR method is further illustrated with real-world data from a longitudinal study of local cervicovaginal HIV viral load and its effects on oncogenic HPV detection in HIV-positive women. Copyright © 2017 John Wiley & Sons, Ltd.

  8. Misconceptions in the use of the General Linear Model applied to functional MRI: a tutorial for junior neuro-imagers

    Directory of Open Access Journals (Sweden)

    Cyril R Pernet

    2014-01-01

    Full Text Available This tutorial presents several misconceptions related to the use the General Linear Model (GLM in functional Magnetic Resonance Imaging (fMRI. The goal is not to present mathematical proofs but to educate using examples and computer code (in Matlab. In particular, I address issues related to (i model parameterization (modelling baseline or null events and scaling of the design matrix; (ii hemodynamic modelling using basis functions, and (iii computing percentage signal change. Using a simple controlled block design and an alternating block design, I first show why 'baseline' should not be modelled (model over-parameterization, and how this affects effect sizes. I also show that, depending on what is tested; over-parameterization does not necessarily impact upon statistical results. Next, using a simple periodic vs. random event related design, I show how the haemodynamic model (haemodynamic function only or using derivatives can affects parameter estimates, as well as detail the role of orthogonalization. I then relate the above results to the computation of percentage signal change. Finally, I discuss how these issues affect group analysis and give some recommendations.

  9. Cadmium-hazard mapping using a general linear regression model (Irr-Cad) for rapid risk assessment.

    Science.gov (United States)

    Simmons, Robert W; Noble, Andrew D; Pongsakul, P; Sukreeyapongse, O; Chinabut, N

    2009-02-01

    Research undertaken over the last 40 years has identified the irrefutable relationship between the long-term consumption of cadmium (Cd)-contaminated rice and human Cd disease. In order to protect public health and livelihood security, the ability to accurately and rapidly determine spatial Cd contamination is of high priority. During 2001-2004, a General Linear Regression Model Irr-Cad was developed to predict the spatial distribution of soil Cd in a Cd/Zn co-contaminated cascading irrigated rice-based system in Mae Sot District, Tak Province, Thailand (Longitude E 98 degrees 59'-E 98 degrees 63' and Latitude N 16 degrees 67'-16 degrees 66'). The results indicate that Irr-Cad accounted for 98% of the variance in mean Field Order total soil Cd. Preliminary validation indicated that Irr-Cad 'predicted' mean Field Order total soil Cd, was significantly (p Myanmar, Lao PDR, Thailand and Yunnan Province, China). These countries also have actively and historically mined Zn, Pb, and Cu deposits where Cd is likely to be a potential hazard if un-controlled discharge/runoff enters areas of rice cultivation. As such, it is envisaged that the Irr-Cad model could be applied for Cd hazard assessment and effectively form the basis of intervention options and policy decisions to protect public health, livelihoods, and export security.

  10. Sparse generalized linear model withL0approximation for feature selection and prediction with big omics data.

    Science.gov (United States)

    Liu, Zhenqiu; Sun, Fengzhu; McGovern, Dermot P

    2017-01-01

    Feature selection and prediction are the most important tasks for big data mining. The common strategies for feature selection in big data mining are L 1 , SCAD and MC+. However, none of the existing algorithms optimizes L 0 , which penalizes the number of nonzero features directly. In this paper, we develop a novel sparse generalized linear model (GLM) with L 0 approximation for feature selection and prediction with big omics data. The proposed approach approximate the L 0 optimization directly. Even though the original L 0 problem is non-convex, the problem is approximated by sequential convex optimizations with the proposed algorithm. The proposed method is easy to implement with only several lines of code. Novel adaptive ridge algorithms ( L 0 ADRIDGE) for L 0 penalized GLM with ultra high dimensional big data are developed. The proposed approach outperforms the other cutting edge regularization methods including SCAD and MC+ in simulations. When it is applied to integrated analysis of mRNA, microRNA, and methylation data from TCGA ovarian cancer, multilevel gene signatures associated with suboptimal debulking are identified simultaneously. The biological significance and potential clinical importance of those genes are further explored. The developed Software L 0 ADRIDGE in MATLAB is available at https://github.com/liuzqx/L0adridge.

  11. Reirradiation with stereotactic body radiotherapy: analysis of human spinal cord tolerance using the generalized linear-quadratic model.

    Science.gov (United States)

    Huang, Zhibin; Mayr, Nina A; Yuh, William T; Wang, Jian Z; Lo, Simon S

    2013-06-01

    Using the generalized linear-quadratic (gLQ) model, we reanalyzed published dosimetric data from patients with radiation myelopathy (RM) after reirradiation with spinal stereotactic body radiotherapy (SBRT). Based on a published study, the thecal sac dose of five RM patients and 14 no RM patients were reanalyzed using gLQ model. Maximum point doses (Pmax) in the thecal sac were obtained. The gLQ-based biological effective doses were calculated and normalized (nBEDgLQ) to a 2-Gy equivalent dose (nBEDgLQ = Gy2/2_gLQ). The initial conventional radiotherapy dose, converted to Gy2/2_gLQ, was added. Total (conventional radiotherapy + SBRT) mean Pmax nBEDgLQ was lower in no RM than RM patients: 59.2 Gy2/2_gLQ (range: 37.5-101.9) versus 94.8 Gy2/2_gLQ (range: 70.2-133.4) (p = 0.0016). The proportion of total Pmax nBEDgLQ accounted for by the SBRT Pmax nBEDgLQ was higher for RM patients. No RMs were seen below a total spinal cord nBEDgLQ of 70 Gy2/2_gLQ. The gLQ-derived spinal cord tolerance for total nBEDgLQ was 70 Gy2/2_gLQ.

  12. A Sequence Kernel Association Test for Dichotomous Traits in Family Samples under a Generalized Linear Mixed Model.

    Science.gov (United States)

    Yan, Qi; Tiwari, Hemant K; Yi, Nengjun; Gao, Guimin; Zhang, Kui; Lin, Wan-Yu; Lou, Xiang-Yang; Cui, Xiangqin; Liu, Nianjun

    2015-01-01

    The existing methods for identifying multiple rare variants underlying complex diseases in family samples are underpowered. Therefore, we aim to develop a new set-based method for an association study of dichotomous traits in family samples. We introduce a framework for testing the association of genetic variants with diseases in family samples based on a generalized linear mixed model. Our proposed method is based on a kernel machine regression and can be viewed as an extension of the sequence kernel association test (SKAT and famSKAT) for application to family data with dichotomous traits (F-SKAT). Our simulation studies show that the original SKAT has inflated type I error rates when applied directly to family data. By contrast, our proposed F-SKAT has the correct type I error rate. Furthermore, in all of the considered scenarios, F-SKAT, which uses all family data, has higher power than both SKAT, which uses only unrelated individuals from the family data, and another method, which uses all family data. We propose a set-based association test that can be used to analyze family data with dichotomous phenotypes while handling genetic variants with the same or opposite directions of effects as well as any types of family relationships. © 2015 S. Karger AG, Basel.

  13. Generalized Linear Mixed Model Analysis of Urban-Rural Differences in Social and Behavioral Factors for Colorectal Cancer Screening

    Science.gov (United States)

    Wang, Ke-Sheng; Liu, Xuefeng; Ategbole, Muyiwa; Xie, Xin; Liu, Ying; Xu, Chun; Xie, Changchun; Sha, Zhanxin

    2017-09-27

    Objective: Screening for colorectal cancer (CRC) can reduce disease incidence, morbidity, and mortality. However, few studies have investigated the urban-rural differences in social and behavioral factors influencing CRC screening. The objective of the study was to investigate the potential factors across urban-rural groups on the usage of CRC screening. Methods: A total of 38,505 adults (aged ≥40 years) were selected from the 2009 California Health Interview Survey (CHIS) data - the latest CHIS data on CRC screening. The weighted generalized linear mixed-model (WGLIMM) was used to deal with this hierarchical structure data. Weighted simple and multiple mixed logistic regression analyses in SAS ver. 9.4 were used to obtain the odds ratios (ORs) and their 95% confidence intervals (CIs). Results: The overall prevalence of CRC screening was 48.1% while the prevalence in four residence groups - urban, second city, suburban, and town/rural, were 45.8%, 46.9%, 53.7% and 50.1%, respectively. The results of WGLIMM analysis showed that there was residence effect (pmodels are useful to deal with the clustered survey data. Social factors and behavioral factors (binge drinking and smoking) were associated with CRC screening and the associations were affected by living areas such as urban and rural regions. Creative Commons Attribution License

  14. Generalized linear solvation energy model applied to solute partition coefficients in ionic liquid-supercritical carbon dioxide systems.

    Science.gov (United States)

    Planeta, Josef; Karásek, Pavel; Hohnová, Barbora; Sťavíková, Lenka; Roth, Michal

    2012-08-10

    Biphasic solvent systems composed of an ionic liquid (IL) and supercritical carbon dioxide (scCO(2)) have become frequented in synthesis, extractions and electrochemistry. In the design of related applications, information on interphase partitioning of the target organics is essential, and the infinite-dilution partition coefficients of the organic solutes in IL-scCO(2) systems can conveniently be obtained by supercritical fluid chromatography. The data base of experimental partition coefficients obtained previously in this laboratory has been employed to test a generalized predictive model for the solute partition coefficients. The model is an amended version of that described before by Hiraga et al. (J. Supercrit. Fluids, in press). Because of difficulty of the problem to be modeled, the model involves several different concepts - linear solvation energy relationships, density-dependent solvent power of scCO(2), regular solution theory, and the Flory-Huggins theory of athermal solutions. The model shows a moderate success in correlating the infinite-dilution solute partition coefficients (K-factors) in individual IL-scCO(2) systems at varying temperature and pressure. However, larger K-factor data sets involving multiple IL-scCO(2) systems appear to be beyond reach of the model, especially when the ILs involved pertain to different cation classes. Copyright © 2012 Elsevier B.V. All rights reserved.

  15. Estimation of breeding values for mean and dispersion, their variance and correlation using double hierarchical generalized linear models.

    Science.gov (United States)

    Felleki, M; Lee, D; Lee, Y; Gilmour, A R; Rönnegård, L

    2012-12-01

    The possibility of breeding for uniform individuals by selecting animals expressing a small response to environment has been studied extensively in animal breeding. Bayesian methods for fitting models with genetic components in the residual variance have been developed for this purpose, but have limitations due to the computational demands. We use the hierarchical (h)-likelihood from the theory of double hierarchical generalized linear models (DHGLM) to derive an estimation algorithm that is computationally feasible for large datasets. Random effects for both the mean and residual variance parts of the model are estimated together with their variance/covariance components. An important feature of the algorithm is that it can fit a correlation between the random effects for mean and variance. An h-likelihood estimator is implemented in the R software and an iterative reweighted least square (IRWLS) approximation of the h-likelihood is implemented using ASReml. The difference in variance component estimates between the two implementations is investigated, as well as the potential bias of the methods, using simulations. IRWLS gives the same results as h-likelihood in simple cases with no severe indication of bias. For more complex cases, only IRWLS could be used, and bias did appear. The IRWLS is applied on the pig litter size data previously analysed by Sorensen & Waagepetersen (2003) using Bayesian methodology. The estimates we obtained by using IRWLS are similar to theirs, with the estimated correlation between the random genetic effects being -0·52 for IRWLS and -0·62 in Sorensen & Waagepetersen (2003).

  16. Group spike-and-slab lasso generalized linear models for disease prediction and associated genes detection by incorporating pathway information.

    Science.gov (United States)

    Tang, Zaixiang; Shen, Yueping; Li, Yan; Zhang, Xinyan; Wen, Jia; Qian, Chen'ao; Zhuang, Wenzhuo; Shi, Xinghua; Yi, Nengjun

    2018-03-15

    Large-scale molecular data have been increasingly used as an important resource for prognostic prediction of diseases and detection of associated genes. However, standard approaches for omics data analysis ignore the group structure among genes encoded in functional relationships or pathway information. We propose new Bayesian hierarchical generalized linear models, called group spike-and-slab lasso GLMs, for predicting disease outcomes and detecting associated genes by incorporating large-scale molecular data and group structures. The proposed model employs a mixture double-exponential prior for coefficients that induces self-adaptive shrinkage amount on different coefficients. The group information is incorporated into the model by setting group-specific parameters. We have developed a fast and stable deterministic algorithm to fit the proposed hierarchal GLMs, which can perform variable selection within groups. We assess the performance of the proposed method on several simulated scenarios, by varying the overlap among groups, group size, number of non-null groups, and the correlation within group. Compared with existing methods, the proposed method provides not only more accurate estimates of the parameters but also better prediction. We further demonstrate the application of the proposed procedure on three cancer datasets by utilizing pathway structures of genes. Our results show that the proposed method generates powerful models for predicting disease outcomes and detecting associated genes. The methods have been implemented in a freely available R package BhGLM (http://www.ssg.uab.edu/bhglm/). nyi@uab.edu. Supplementary data are available at Bioinformatics online.

  17. Equilibrium stochastic dynamics of Poisson cluster ensembles

    Directory of Open Access Journals (Sweden)

    L.Bogachev

    2008-06-01

    Full Text Available The distribution μ of a Poisson cluster process in Χ=Rd (with n-point clusters is studied via the projection of an auxiliary Poisson measure in the space of configurations in Χn, with the intensity measure being the convolution of the background intensity (of cluster centres with the probability distribution of a generic cluster. We show that μ is quasi-invariant with respect to the group of compactly supported diffeomorphisms of Χ, and prove an integration by parts formula for μ. The corresponding equilibrium stochastic dynamics is then constructed using the method of Dirichlet forms.

  18. White Noise of Poisson Random Measures

    OpenAIRE

    Proske, Frank; Øksendal, Bernt

    2002-01-01

    We develop a white noise theory for Poisson random measures associated with a Lévy process. The starting point of this theory is a chaos expansion with kernels of polynomial type. We use this to construct the white noise of a Poisson random measure, which takes values in a certain distribution space. Then we show, how a Skorohod/Itô integral for point processes can be represented by a Bochner integral in terms of white noise of the random measure and a Wick product. Further, we apply these co...

  19. Bayesian regression of piecewise homogeneous Poisson processes

    Directory of Open Access Journals (Sweden)

    Diego Sevilla

    2015-12-01

    Full Text Available In this paper, a Bayesian method for piecewise regression is adapted to handle counting processes data distributed as Poisson. A numerical code in Mathematica is developed and tested analyzing simulated data. The resulting method is valuable for detecting breaking points in the count rate of time series for Poisson processes. Received: 2 November 2015, Accepted: 27 November 2015; Edited by: R. Dickman; Reviewed by: M. Hutter, Australian National University, Canberra, Australia.; DOI: http://dx.doi.org/10.4279/PIP.070018 Cite as: D J R Sevilla, Papers in Physics 7, 070018 (2015

  20. Spatial Nonhomogeneous Poisson Process in Corrosion Management

    NARCIS (Netherlands)

    López De La Cruz, J.; Kuniewski, S.P.; Van Noortwijk, J.M.; Guriérrez, M.A.

    2008-01-01

    A method to test the assumption of nonhomogeneous Poisson point processes is implemented to analyze corrosion pit patterns. The method is calibrated with three artificially generated patterns and manages to accurately assess whether a pattern distribution is random, regular, or clustered. The

  1. Efficient information transfer by Poisson neurons

    Czech Academy of Sciences Publication Activity Database

    Košťál, Lubomír; Shinomoto, S.

    2016-01-01

    Roč. 13, č. 3 (2016), s. 509-520 ISSN 1547-1063 R&D Projects: GA ČR(CZ) GA15-08066S Institutional support: RVO:67985823 Keywords : information capacity * Poisson neuron * metabolic cost * decoding error Subject RIV: BD - Theory of Information Impact factor: 1.035, year: 2016

  2. Natural Poisson structures of nonlinear plasma dynamics

    International Nuclear Information System (INIS)

    Kaufman, A.N.

    1982-06-01

    Hamiltonian field theories, for models of nonlinear plasma dynamics, require a Poisson bracket structure for functionals of the field variables. These are presented, applied, and derived for several sets of field variables: coherent waves, incoherent waves, particle distributions, and multifluid electrodynamics. Parametric coupling of waves and plasma yields concise expressions for ponderomotive effects (in kinetic and fluid models) and for induced scattering

  3. Natural Poisson structures of nonlinear plasma dynamics

    International Nuclear Information System (INIS)

    Kaufman, A.N.

    1982-01-01

    Hamiltonian field theories, for models of nonlinear plasma dynamics, require a Poisson bracket structure for functionals of the field variables. These are presented, applied, and derived for several sets of field variables: coherent waves, incoherent waves, particle distributions, and multifluid electrodynamics. Parametric coupling of waves and plasma yields concise expressions for ponderomotive effects (in kinetic and fluid models) and for induced scattering. (Auth.)

  4. Poisson brackets for fluids and plasmas

    International Nuclear Information System (INIS)

    Morrison, P.J.

    1982-01-01

    Noncanonical yet Hamiltonian descriptions are presented of many of the non-dissipative field equations that govern fluids and plasmas. The dynamical variables are the usually encountered physical variables. These descriptions have the advantage that gauge conditions are absent, but at the expense of introducing peculiar Poisson brackets. Clebsch-like potential descriptions that reverse this situations are also introduced

  5. Almost Poisson integration of rigid body systems

    International Nuclear Information System (INIS)

    Austin, M.A.; Krishnaprasad, P.S.; Li-Sheng Wang

    1993-01-01

    In this paper we discuss the numerical integration of Lie-Poisson systems using the mid-point rule. Since such systems result from the reduction of hamiltonian systems with symmetry by lie group actions, we also present examples of reconstruction rules for the full dynamics. A primary motivation is to preserve in the integration process, various conserved quantities of the original dynamics. A main result of this paper is an O(h 3 ) error estimate for the Lie-Poisson structure, where h is the integration step-size. We note that Lie-Poisson systems appear naturally in many areas of physical science and engineering, including theoretical mechanics of fluids and plasmas, satellite dynamics, and polarization dynamics. In the present paper we consider a series of progressively complicated examples related to rigid body systems. We also consider a dissipative example associated to a Lie-Poisson system. The behavior of the mid-point rule and an associated reconstruction rule is numerically explored. 24 refs., 9 figs

  6. Affine Poisson Groups and WZW Model

    Directory of Open Access Journals (Sweden)

    Ctirad Klimcík

    2008-01-01

    Full Text Available We give a detailed description of a dynamical system which enjoys a Poisson-Lie symmetry with two non-isomorphic dual groups. The system is obtained by taking the q → ∞ limit of the q-deformed WZW model and the understanding of its symmetry structure results in uncovering an interesting duality of its exchange relations.

  7. Examining secular trends and seasonality in count data using dynamic generalized linear modelling: a new methodological approach illustrated with hospital discharge data on myocardial infarction.

    Science.gov (United States)

    Lundbye-Christensen, S; Dethlefsen, C; Gorst-Rasmussen, A; Fischer, T; Schønheyder, H C; Rothman, K J; Sørensen, H T

    2009-01-01

    Time series of incidence counts often show secular trends and seasonal patterns. We present a model for incidence counts capable of handling a possible gradual change in growth rates and seasonal patterns, serial correlation, and overdispersion. The model resembles an ordinary time series regression model for Poisson counts. It differs in allowing the regression coefficients to vary gradually over time in a random fashion. During the 1983-1999 period, 17,989 incidents of acute myocardial infarction were recorded in the Hospital Discharge Registry for the county of North Jutland, Denmark. Records were updated daily. A dynamic model with a seasonal pattern and an approximately linear trend was fitted to the data, and diagnostic plots indicated a good model fit. The analysis conducted with the dynamic model revealed peaks coinciding with above-average influenza A activity. On average the dynamic model estimated a higher peak-to-trough ratio than traditional models, and showed gradual changes in seasonal patterns. Analyses conducted with this model provide insights not available from more traditional approaches.

  8. Kalman estimator- and general linear model-based on-line brain activation mapping by near-infrared spectroscopy

    Directory of Open Access Journals (Sweden)

    Ge Shuzhi S

    2010-12-01

    Full Text Available Abstract Background Near-infrared spectroscopy (NIRS is a non-invasive neuroimaging technique that recently has been developed to measure the changes of cerebral blood oxygenation associated with brain activities. To date, for functional brain mapping applications, there is no standard on-line method for analysing NIRS data. Methods In this paper, a novel on-line NIRS data analysis framework taking advantages of both the general linear model (GLM and the Kalman estimator is devised. The Kalman estimator is used to update the GLM coefficients recursively, and one critical coefficient regarding brain activities is then passed to a t-statistical test. The t-statistical test result is used to update a topographic brain activation map. Meanwhile, a set of high-pass filters is plugged into the GLM to prevent very low-frequency noises, and an autoregressive (AR model is used to prevent the temporal correlation caused by physiological noises in NIRS time series. A set of data recorded in finger tapping experiments is studied using the proposed framework. Results The obtained results suggest that the method can effectively track the task related brain activation areas, and prevent the noise distortion in the estimation while the experiment is running. Thereby, the potential of the proposed method for real-time NIRS-based brain imaging was demonstrated. Conclusions This paper presents a novel on-line approach for analysing NIRS data for functional brain mapping applications. This approach demonstrates the potential of a real-time-updating topographic brain activation map.

  9. Nested generalized linear mixed model with ordinal response: Simulation and application on poverty data in Java Island

    Science.gov (United States)

    Widyaningsih, Yekti; Saefuddin, Asep; Notodiputro, Khairil A.; Wigena, Aji H.

    2012-05-01

    The objective of this research is to build a nested generalized linear mixed model using an ordinal response variable with some covariates. There are three main jobs in this paper, i.e. parameters estimation procedure, simulation, and implementation of the model for the real data. At the part of parameters estimation procedure, concepts of threshold, nested random effect, and computational algorithm are described. The simulations data are built for 3 conditions to know the effect of different parameter values of random effect distributions. The last job is the implementation of the model for the data about poverty in 9 districts of Java Island. The districts are Kuningan, Karawang, and Majalengka chose randomly in West Java; Temanggung, Boyolali, and Cilacap from Central Java; and Blitar, Ngawi, and Jember from East Java. The covariates in this model are province, number of bad nutrition cases, number of farmer families, and number of health personnel. In this modeling, all covariates are grouped as ordinal scale. Unit observation in this research is sub-district (kecamatan) nested in district, and districts (kabupaten) are nested in province. For the result of simulation, ARB (Absolute Relative Bias) and RRMSE (Relative Root of mean square errors) scale is used. They show that prov parameters have the highest bias, but more stable RRMSE in all conditions. The simulation design needs to be improved by adding other condition, such as higher correlation between covariates. Furthermore, as the result of the model implementation for the data, only number of farmer family and number of medical personnel have significant contributions to the level of poverty in Central Java and East Java province, and only district 2 (Karawang) of province 1 (West Java) has different random effect from the others. The source of the data is PODES (Potensi Desa) 2008 from BPS (Badan Pusat Statistik).

  10. A generalized linear-quadratic model for radiosurgery, stereotactic body radiation therapy, and high-dose rate brachytherapy.

    Science.gov (United States)

    Wang, Jian Z; Huang, Zhibin; Lo, Simon S; Yuh, William T C; Mayr, Nina A

    2010-07-07

    Conventional radiation therapy for cancer usually consists of multiple treatments (called fractions) with low doses of radiation. These dose schemes are planned with the guidance of the linear-quadratic (LQ) model, which has been the most prevalent model for designing dose schemes in radiation therapy. The high-dose fractions used in newer advanced radiosurgery, stereotactic radiation therapy, and high-dose rate brachytherapy techniques, however, cannot be accurately calculated with the traditional LQ model. To address this problem, we developed a generalized LQ (gLQ) model that encompasses the entire range of possible dose delivery patterns and derived formulas for special radiotherapy schemes. We show that the gLQ model can naturally derive the traditional LQ model for low-dose and low-dose rate irradiation and the target model for high-dose irradiation as two special cases of gLQ. LQ and gLQ models were compared with published data obtained in vitro from Chinese hamster ovary cells across a wide dose range [0 to approximately 11.5 gray (Gy)] and from animals with dose fractions up to 13.5 Gy. The gLQ model provided consistent interpretation across the full dose range, whereas the LQ model generated parameters that depended on dose range, fitted only data with doses of 3.25 Gy or less, and failed to predict high-dose responses. Therefore, the gLQ model is useful for analyzing experimental radiation response data across wide dose ranges and translating common low-dose clinical experience into high-dose radiotherapy schemes for advanced radiation treatments.

  11. Does a physical activity program in the nursing home impact on depressive symptoms? A generalized linear mixed-model approach.

    Science.gov (United States)

    Diegelmann, Mona; Jansen, Carl-Philipp; Wahl, Hans-Werner; Schilling, Oliver K; Schnabel, Eva-Luisa; Hauer, Klaus

    2017-04-18

    Physical activity (PA) may counteract depressive symptoms in nursing home (NH) residents considering biological, psychological, and person-environment transactional pathways. Empirical results, however, have remained inconsistent. Addressing potential shortcomings of previous research, we examined the effect of a whole-ecology PA intervention program on NH residents' depressive symptoms using generalized linear mixed-models (GLMMs). We used longitudinal data from residents of two German NHs who were included without any pre-selection regarding physical and mental functioning (n = 163, M age = 83.1, 53-100 years; 72% female) and assessed on four occasions each three months apart. Residents willing to participate received a 12-week PA training program. Afterwards, the training was implemented in weekly activity schedules by NH staff. We ran GLMMs to account for the highly skewed depressive symptoms outcome measure (12-item Geriatric Depression Scale-Residential) by using gamma distribution. Exercising (n = 78) and non-exercising residents (n = 85) showed a comparable level of depressive symptoms at pretest. For exercising residents, depressive symptoms stabilized between pre-, posttest, and at follow-up, whereas an increase was observed for non-exercising residents. The intervention group's stabilization in depressive symptoms was maintained at follow-up, but increased further for non-exercising residents. Implementing an innovative PA intervention appears to be a promising approach to prevent the increase of NH residents' depressive symptoms. At the data-analytical level, GLMMs seem to be a promising tool for intervention research at large, because all longitudinally available data points and non-normality of outcome data can be considered.

  12. Using empirical Bayes predictors from generalized linear mixed models to test and visualize associations among longitudinal outcomes.

    Science.gov (United States)

    Mikulich-Gilbertson, Susan K; Wagner, Brandie D; Grunwald, Gary K; Riggs, Paula D; Zerbe, Gary O

    2018-01-01

    Medical research is often designed to investigate changes in a collection of response variables that are measured repeatedly on the same subjects. The multivariate generalized linear mixed model (MGLMM) can be used to evaluate random coefficient associations (e.g. simple correlations, partial regression coefficients) among outcomes that may be non-normal and differently distributed by specifying a multivariate normal distribution for their random effects and then evaluating the latent relationship between them. Empirical Bayes predictors are readily available for each subject from any mixed model and are observable and hence, plotable. Here, we evaluate whether second-stage association analyses of empirical Bayes predictors from a MGLMM, provide a good approximation and visual representation of these latent association analyses using medical examples and simulations. Additionally, we compare these results with association analyses of empirical Bayes predictors generated from separate mixed models for each outcome, a procedure that could circumvent computational problems that arise when the dimension of the joint covariance matrix of random effects is large and prohibits estimation of latent associations. As has been shown in other analytic contexts, the p-values for all second-stage coefficients that were determined by naively assuming normality of empirical Bayes predictors provide a good approximation to p-values determined via permutation analysis. Analyzing outcomes that are interrelated with separate models in the first stage and then associating the resulting empirical Bayes predictors in a second stage results in different mean and covariance parameter estimates from the maximum likelihood estimates generated by a MGLMM. The potential for erroneous inference from using results from these separate models increases as the magnitude of the association among the outcomes increases. Thus if computable, scatterplots of the conditionally independent empirical Bayes

  13. High predictor dimensionality in slope-unit-based landslide susceptibility models through LASSO-penalized Generalized Linear Model

    Science.gov (United States)

    Lombardo, Luigi; Castro-Camilo, Daniela; Mai, Martin; Jie, Dou; Huser, Raphaël

    2017-04-01

    Grid-based landslide susceptibility models at regional scales are computationally demanding when using a fine grid resolution. Conversely, Slope-Unit (SU) based susceptibility models allows to investigate the same areas offering two main advantages: 1) a smaller computational burden and 2) a more geomorphologically-oriented output. In this contribution, we generate a SU-based landslide susceptibility for the Sado Island in Japan. This island is characterized by deep-seated landslides which we assume can only limitedly be explained by the first two statistical moments (mean and variance) of a set of predictors within each slope unit. As a consequence, in a nested experiment, we first analyze the distributions of a set of continuous predictors within each slope unit computing the standard deviation and quantiles from 0.05 to 0.95 with a step of 0.05 which were then used as predictors for landslide susceptibility. In addition, we combined shape indices for polygon features and the normalized extent of each class belonging to the outcropping lithology in a given SU. This procedure significantly enlarges the size of the predictor hyperspace, thus producing a high level of slope-unit characterization. In a second step, we adopt a LASSO-penalized Generalized Linear Model to reduce the predictor set to a sensible and interpretable number, carrying only the most significant covariates in the models. As a result, we are able to identify the geomorphic features that primarily control the SU-based susceptibility within the test area while producing high predictive performances. Level 4 validation procedures were implemented to assess uncertainty and quality of the models through a set of 500 randomly generated replicates.

  14. Assessing the economic impact of paternal involvement: a comparison of the generalized linear model versus decision analysis trees.

    Science.gov (United States)

    Salihu, Hamisu M; Salemi, Jason L; Nash, Michelle C; Chandler, Kristen; Mbah, Alfred K; Alio, Amina P

    2014-08-01

    Lack of paternal involvement has been shown to be associated with adverse pregnancy outcomes, including infant morbidity and mortality, but the impact on health care costs is unknown. Various methodological approaches have been used in cost minimization and cost effectiveness analyses and it remains unclear how cost estimates vary according to the analytic strategy adopted. We illustrate a methodological comparison of decision analysis modeling and generalized linear modeling (GLM) techniques using a case study that assesses the cost-effectiveness of potential father involvement interventions. We conducted a 12-year retrospective cohort study using a statewide enhanced maternal-infant database that contains both clinical and nonclinical information. A missing name for the father on the infant's birth certificate was used as a proxy for lack of paternal involvement, the main exposure of this study. Using decision analysis modeling and GLM, we compared all infant inpatient hospitalization costs over the first year of life. Costs were calculated from hospital charges using department-level cost-to-charge ratios and were adjusted for inflation. In our cohort of 2,243,891 infants, 9.2% had a father uninvolved during pregnancy. Lack of paternal involvement was associated with higher rates of preterm birth, small-for-gestational age, and infant morbidity and mortality. Both analytic approaches estimate significantly higher per-infant costs for father uninvolved pregnancies (decision analysis model: $1,827, GLM: $1,139). This paper provides sufficient evidence that healthcare costs could be significantly reduced through enhanced father involvement during pregnancy, and buttresses the call for a national program to involve fathers in antenatal care.

  15. Handling high predictor dimensionality in slope-unit-based landslide susceptibility models through LASSO-penalized Generalized Linear Model

    KAUST Repository

    Camilo, Daniela Castro

    2017-08-30

    Grid-based landslide susceptibility models at regional scales are computationally demanding when using a fine grid resolution. Conversely, Slope-Unit (SU) based susceptibility models allows to investigate the same areas offering two main advantages: 1) a smaller computational burden and 2) a more geomorphologically-oriented interpretation. In this contribution, we generate SU-based landslide susceptibility for the Sado Island in Japan. This island is characterized by deep-seated landslides which we assume can only limitedly be explained by the first two statistical moments (mean and variance) of a set of predictors within each slope unit. As a consequence, in a nested experiment, we first analyse the distributions of a set of continuous predictors within each slope unit computing the standard deviation and quantiles from 0.05 to 0.95 with a step of 0.05. These are then used as predictors for landslide susceptibility. In addition, we combine shape indices for polygon features and the normalized extent of each class belonging to the outcropping lithology in a given SU. This procedure significantly enlarges the size of the predictor hyperspace, thus producing a high level of slope-unit characterization. In a second step, we adopt a LASSO-penalized Generalized Linear Model to shrink back the predictor set to a sensible and interpretable number, carrying only the most significant covariates in the models. As a result, we are able to document the geomorphic features (e.g., 95% quantile of Elevation and 5% quantile of Plan Curvature) that primarily control the SU-based susceptibility within the test area while producing high predictive performances. The implementation of the statistical analyses are included in a parallelized R script (LUDARA) which is here made available for the community to replicate analogous experiments.

  16. Controllability of nonlocal second-order impulsive neutral stochastic functional integro-differential equations with delay and Poisson jumps

    Directory of Open Access Journals (Sweden)

    Diem Dang Huan

    2015-12-01

    Full Text Available The current paper is concerned with the controllability of nonlocal second-order impulsive neutral stochastic functional integro-differential equations with infinite delay and Poisson jumps in Hilbert spaces. Using the theory of a strongly continuous cosine family of bounded linear operators, stochastic analysis theory and with the help of the Banach fixed point theorem, we derive a new set of sufficient conditions for the controllability of nonlocal second-order impulsive neutral stochastic functional integro-differential equations with infinite delay and Poisson jumps. Finally, an application to the stochastic nonlinear wave equation with infinite delay and Poisson jumps is given.

  17. Direct 4D parametric imaging for linearized models of reversibly binding PET tracers using generalized AB-EM reconstruction

    Science.gov (United States)

    Rahmim, Arman; Zhou, Yun; Tang, Jing; Lu, Lijun; Sossi, Vesna; Wong, Dean F.

    2012-01-01

    Due to high noise levels in the voxel kinetics, development of reliable parametric imaging algorithms remains as one of most active areas in dynamic brain PET imaging, which in the vast majority of cases involves receptor/transporter studies with reversibly binding tracers. As such, the focus of this work has been to develop a novel direct 4D parametric image reconstruction scheme for such tracers. Based on a relative equilibrium (RE) graphical analysis formulation (Zhou et al., 2009b), we developed a closed-form 4D EM algorithm to directly reconstruct distribution volume (DV) parametric images within a plasma input model, as well as DV ratio (DVR) images within a reference tissue model scheme (wherein an initial reconstruction was used to estimate the reference tissue time-activity-curves). A particular challenge with the direct 4D EM formulation is that the intercept parameters in graphical (linearized) analysis of reversible tracers (e.g. Logan or RE analysis) are commonly negative (unlike for irreversible tracers; e.g. using Patlak analysis). Subsequently, we focused our attention on the AB-EM algorithm, derived by Byrne (1998) to allow inclusion of prior information about the lower (A) and upper (B) bounds for image values. We then generalized this algorithm to the 4D EM framework thus allowing negative intercept parameters. Furthermore, our 4D AB-EM algorithm incorporated, and emphasized the use of spatially varying lower bounds to achieve enhanced performance. As validation, the means of parameters estimated from 55 human 11C-raclopride dynamic PET studies were used for extensive simulations using a mathematical brain phantom. Images were reconstructed using conventional indirect as well as proposed direct parametric imaging methods. Noise vs. bias quantitative measurements were performed in various regions of the brain. Direct 4D EM reconstruction resulted in notable qualitative and quantitative accuracy improvements (over 35% noise reduction, with matched

  18. Comparing artificial neural networks, general linear models and support vector machines in building predictive models for small interfering RNAs.

    Directory of Open Access Journals (Sweden)

    Kyle A McQuisten

    2009-10-01

    Full Text Available Exogenous short interfering RNAs (siRNAs induce a gene knockdown effect in cells by interacting with naturally occurring RNA processing machinery. However not all siRNAs induce this effect equally. Several heterogeneous kinds of machine learning techniques and feature sets have been applied to modeling siRNAs and their abilities to induce knockdown. There is some growing agreement to which techniques produce maximally predictive models and yet there is little consensus for methods to compare among predictive models. Also, there are few comparative studies that address what the effect of choosing learning technique, feature set or cross validation approach has on finding and discriminating among predictive models.Three learning techniques were used to develop predictive models for effective siRNA sequences including Artificial Neural Networks (ANNs, General Linear Models (GLMs and Support Vector Machines (SVMs. Five feature mapping methods were also used to generate models of siRNA activities. The 2 factors of learning technique and feature mapping were evaluated by complete 3x5 factorial ANOVA. Overall, both learning techniques and feature mapping contributed significantly to the observed variance in predictive models, but to differing degrees for precision and accuracy as well as across different kinds and levels of model cross-validation.The methods presented here provide a robust statistical framework to compare among models developed under distinct learning techniques and feature sets for siRNAs. Further comparisons among current or future modeling approaches should apply these or other suitable statistically equivalent methods to critically evaluate the performance of proposed models. ANN and GLM techniques tend to be more sensitive to the inclusion of noisy features, but the SVM technique is more robust under large numbers of features for measures of model precision and accuracy. Features found to result in maximally predictive models are

  19. Permutation-based variance component test in generalized linear mixed model with application to multilocus genetic association study.

    Science.gov (United States)

    Zeng, Ping; Zhao, Yang; Li, Hongliang; Wang, Ting; Chen, Feng

    2015-04-22

    In many medical studies the likelihood ratio test (LRT) has been widely applied to examine whether the random effects variance component is zero within the mixed effects models framework; whereas little work about likelihood-ratio based variance component test has been done in the generalized linear mixed models (GLMM), where the response is discrete and the log-likelihood cannot be computed exactly. Before applying the LRT for variance component in GLMM, several difficulties need to be overcome, including the computation of the log-likelihood, the parameter estimation and the derivation of the null distribution for the LRT statistic. To overcome these problems, in this paper we make use of the penalized quasi-likelihood algorithm and calculate the LRT statistic based on the resulting working response and the quasi-likelihood. The permutation procedure is used to obtain the null distribution of the LRT statistic. We evaluate the permutation-based LRT via simulations and compare it with the score-based variance component test and the tests based on the mixture of chi-square distributions. Finally we apply the permutation-based LRT to multilocus association analysis in the case-control study, where the problem can be investigated under the framework of logistic mixed effects model. The simulations show that the permutation-based LRT can effectively control the type I error rate, while the score test is sometimes slightly conservative and the tests based on mixtures cannot maintain the type I error rate. Our studies also show that the permutation-based LRT has higher power than these existing tests and still maintains a reasonably high power even when the random effects do not follow a normal distribution. The application to GAW17 data also demonstrates that the proposed LRT has a higher probability to identify the association signals than the score test and the tests based on mixtures. In the present paper the permutation-based LRT was developed for variance

  20. Linearization Method and Linear Complexity

    Science.gov (United States)

    Tanaka, Hidema

    We focus on the relationship between the linearization method and linear complexity and show that the linearization method is another effective technique for calculating linear complexity. We analyze its effectiveness by comparing with the logic circuit method. We compare the relevant conditions and necessary computational cost with those of the Berlekamp-Massey algorithm and the Games-Chan algorithm. The significant property of a linearization method is that it needs no output sequence from a pseudo-random number generator (PRNG) because it calculates linear complexity using the algebraic expression of its algorithm. When a PRNG has n [bit] stages (registers or internal states), the necessary computational cost is smaller than O(2n). On the other hand, the Berlekamp-Massey algorithm needs O(N2) where N(≅2n) denotes period. Since existing methods calculate using the output sequence, an initial value of PRNG influences a resultant value of linear complexity. Therefore, a linear complexity is generally given as an estimate value. On the other hand, a linearization method calculates from an algorithm of PRNG, it can determine the lower bound of linear complexity.

  1. Poisson/Superfish codes for personal computers

    International Nuclear Information System (INIS)

    Humphries, S.

    1992-01-01

    The Poisson/Superfish codes calculate static E or B fields in two-dimensions and electromagnetic fields in resonant structures. New versions for 386/486 PCs and Macintosh computers have capabilities that exceed the mainframe versions. Notable improvements are interactive graphical post-processors, improved field calculation routines, and a new program for charged particle orbit tracking. (author). 4 refs., 1 tab., figs

  2. Elementary derivation of Poisson structures for fluid dynamics and electrodynamics

    International Nuclear Information System (INIS)

    Kaufman, A.N.

    1982-01-01

    The canonical Poisson structure of the microscopic Lagrangian is used to deduce the noncanonical Poisson structure for the macroscopic Hamiltonian dynamics of a compressible neutral fluid and of fluid electrodynamics

  3. Poisson Plus Quantification for Digital PCR Systems.

    Science.gov (United States)

    Majumdar, Nivedita; Banerjee, Swapnonil; Pallas, Michael; Wessel, Thomas; Hegerich, Patricia

    2017-08-29

    Digital PCR, a state-of-the-art nucleic acid quantification technique, works by spreading the target material across a large number of partitions. The average number of molecules per partition is estimated using Poisson statistics, and then converted into concentration by dividing by partition volume. In this standard approach, identical partition sizing is assumed. Violations of this assumption result in underestimation of target quantity, when using Poisson modeling, especially at higher concentrations. The Poisson-Plus Model accommodates for this underestimation, if statistics of the volume variation are well characterized. The volume variation was measured on the chip array based QuantStudio 3D Digital PCR System using the ROX fluorescence level as a proxy for effective load volume per through-hole. Monte Carlo simulations demonstrate the efficacy of the proposed correction. Empirical measurement of model parameters characterizing the effective load volume on QuantStudio 3D Digital PCR chips is presented. The model was used to analyze digital PCR experiments and showed improved accuracy in quantification. At the higher concentrations, the modeling must take effective fill volume variation into account to produce accurate estimates. The extent of the difference from the standard to the new modeling is positively correlated to the extent of fill volume variation in the effective load of your reactions.

  4. Study on generalized Toda mechanics system with loop algebra L(Dr)

    International Nuclear Information System (INIS)

    Zhu Qiao; Yang Zhanying; Shi Kangjie

    2005-01-01

    The authors generalize the Toda mechanics system with long range interaction to the case of Loop algebra L(D r ). By using a pair of ordered positive integer (X, Y) to describe Toda chains, authors extract the equation of motion and the Hamiltonian structure of this system for (3, 2) Toda chain. It turns out that both extra coordinates and standard Toda variables are Poisson non-commutative in the case of nontrivial generalization, and for some case, extra variables appear linearly on the right hand side of the Poisson bracket. (authors)

  5. Collision prediction models using multivariate Poisson-lognormal regression.

    Science.gov (United States)

    El-Basyouny, Karim; Sayed, Tarek

    2009-07-01

    This paper advocates the use of multivariate Poisson-lognormal (MVPLN) regression to develop models for collision count data. The MVPLN approach presents an opportunity to incorporate the correlations across collision severity levels and their influence on safety analyses. The paper introduces a new multivariate hazardous location identification technique, which generalizes the univariate posterior probability of excess that has been commonly proposed and applied in the literature. In addition, the paper presents an alternative approach for quantifying the effect of the multivariate structure on the precision of expected collision frequency. The MVPLN approach is compared with the independent (separate) univariate Poisson-lognormal (PLN) models with respect to model inference, goodness-of-fit, identification of hot spots and precision of expected collision frequency. The MVPLN is modeled using the WinBUGS platform which facilitates computation of posterior distributions as well as providing a goodness-of-fit measure for model comparisons. The results indicate that the estimates of the extra Poisson variation parameters were considerably smaller under MVPLN leading to higher precision. The improvement in precision is due mainly to the fact that MVPLN accounts for the correlation between the latent variables representing property damage only (PDO) and injuries plus fatalities (I+F). This correlation was estimated at 0.758, which is highly significant, suggesting that higher PDO rates are associated with higher I+F rates, as the collision likelihood for both types is likely to rise due to similar deficiencies in roadway design and/or other unobserved factors. In terms of goodness-of-fit, the MVPLN model provided a superior fit than the independent univariate models. The multivariate hazardous location identification results demonstrated that some hazardous locations could be overlooked if the analysis was restricted to the univariate models.

  6. Semiparametric bivariate zero-inflated Poisson models with application to studies of abundance for multiple species

    Science.gov (United States)

    Arab, Ali; Holan, Scott H.; Wikle, Christopher K.; Wildhaber, Mark L.

    2012-01-01

    Ecological studies involving counts of abundance, presence–absence or occupancy rates often produce data having a substantial proportion of zeros. Furthermore, these types of processes are typically multivariate and only adequately described by complex nonlinear relationships involving externally measured covariates. Ignoring these aspects of the data and implementing standard approaches can lead to models that fail to provide adequate scientific understanding of the underlying ecological processes, possibly resulting in a loss of inferential power. One method of dealing with data having excess zeros is to consider the class of univariate zero-inflated generalized linear models. However, this class of models fails to address the multivariate and nonlinear aspects associated with the data usually encountered in practice. Therefore, we propose a semiparametric bivariate zero-inflated Poisson model that takes into account both of these data attributes. The general modeling framework is hierarchical Bayes and is suitable for a broad range of applications. We demonstrate the effectiveness of our model through a motivating example on modeling catch per unit area for multiple species using data from the Missouri River Benthic Fishes Study, implemented by the United States Geological Survey.

  7. Towards a Robust Solution of the Non-Linear Kinematics for the General Stewart Platform with Estimation of Distribution Algorithms

    Directory of Open Access Journals (Sweden)

    Eusebio Eduardo Hernández Martinez

    2013-01-01

    Full Text Available In robotics, solving the direct kinematics problem (DKP for parallel robots is very often more difficult and time consuming than for their serial counterparts. The problem is stated as follows: given the joint variables, the Cartesian variables should be computed, namely the pose of the mobile platform. Most of the time, the DKP requires solving a non-linear system of equations. In addition, given that the system could be non-convex, Newton or Quasi-Newton (Dogleg based solvers get trapped on local minima. The capacity of such kinds of solvers to find an adequate solution strongly depends on the starting point. A well-known problem is the selection of such a starting point, which requires a priori information about the neighbouring region of the solution. In order to circumvent this issue, this article proposes an efficient method to select and to generate the starting point based on probabilistic learning. Experiments and discussion are presented to show the method performance. The method successfully avoids getting trapped on local minima without the need for human intervention, which increases its robustness when compared with a single Dogleg approach. This proposal can be extended to other structures, to any non-linear system of equations, and of course, to non-linear optimization problems.

  8. Inexact Bregman iteration with an application to Poisson data reconstruction

    Science.gov (United States)

    Benfenati, A.; Ruggiero, V.

    2013-06-01

    This work deals with the solution of image restoration problems by an iterative regularization method based on the Bregman iteration. Any iteration of this scheme requires the exact computation of the minimizer of a function. However, in some image reconstruction applications, it is either impossible or extremely expensive to obtain exact solutions of these subproblems. In this paper, we propose an inexact version of the iterative procedure, where the inexactness in the inner subproblem solution is controlled by a criterion that preserves the convergence of the Bregman iteration and its features in image restoration problems. In particular, the method allows us to obtain accurate reconstructions also when only an overestimation of the regularization parameter is known. The introduction of the inexactness in the iterative scheme allows us to address image reconstruction problems from data corrupted by Poisson noise, exploiting the recent advances about specialized algorithms for the numerical minimization of the generalized Kullback-Leibler divergence combined with a regularization term. The results of several numerical experiments enable us to evaluate the proposed scheme for image deblurring or denoising in the presence of Poisson noise.

  9. Analysis of overdispersed count data by mixtures of Poisson variables and Poisson processes.

    Science.gov (United States)

    Hougaard, P; Lee, M L; Whitmore, G A

    1997-12-01

    Count data often show overdispersion compared to the Poisson distribution. Overdispersion is typically modeled by a random effect for the mean, based on the gamma distribution, leading to the negative binomial distribution for the count. This paper considers a larger family of mixture distributions, including the inverse Gaussian mixture distribution. It is demonstrated that it gives a significantly better fit for a data set on the frequency of epileptic seizures. The same approach can be used to generate counting processes from Poisson processes, where the rate or the time is random. A random rate corresponds to variation between patients, whereas a random time corresponds to variation within patients.

  10. Optimal linear filtering of general multidimensional Gaussian processes and its application to Laplace transforms of quadratic functionals

    Directory of Open Access Journals (Sweden)

    M. L. Kleptsyna

    2001-01-01

    Full Text Available The optimal filtering problem for multidimensional continuous possibly non-Markovian, Gaussian processes, observed through a linear channel driven by a Brownian motion, is revisited. Explicit Volterra type filtering equations involving the covariance function of the filtered process are derived both for the conditional mean and for the covariance of the filtering error. The solution of the filtering problem is applied to obtain a Cameron-Martin type formula for Laplace transforms of a quadratic functional of the process. Particular cases for which the results can be further elaborated are investigated.

  11. Linear regression

    CERN Document Server

    Olive, David J

    2017-01-01

    This text covers both multiple linear regression and some experimental design models. The text uses the response plot to visualize the model and to detect outliers, does not assume that the error distribution has a known parametric distribution, develops prediction intervals that work when the error distribution is unknown, suggests bootstrap hypothesis tests that may be useful for inference after variable selection, and develops prediction regions and large sample theory for the multivariate linear regression model that has m response variables. A relationship between multivariate prediction regions and confidence regions provides a simple way to bootstrap confidence regions. These confidence regions often provide a practical method for testing hypotheses. There is also a chapter on generalized linear models and generalized additive models. There are many R functions to produce response and residual plots, to simulate prediction intervals and hypothesis tests, to detect outliers, and to choose response trans...

  12. Binomial vs poisson statistics in radiation studies

    International Nuclear Information System (INIS)

    Foster, J.; Kouris, K.; Spyrou, N.M.; Matthews, I.P.; Welsh National School of Medicine, Cardiff

    1983-01-01

    The processes of radioactive decay, decay and growth of radioactive species in a radioactive chain, prompt emission(s) from nuclear reactions, conventional activation and cyclic activation are discussed with respect to their underlying statistical density function. By considering the transformation(s) that each nucleus may undergo it is shown that all these processes are fundamentally binomial. Formally, when the number of experiments N is large and the probability of success p is close to zero, the binomial is closely approximated by the Poisson density function. In radiation and nuclear physics, N is always large: each experiment can be conceived of as the observation of the fate of each of the N nuclei initially present. Whether p, the probability that a given nucleus undergoes a prescribed transformation, is close to zero depends on the process and nuclide(s) concerned. Hence, although a binomial description is always valid, the Poisson approximation is not always adequate. Therefore further clarification is provided as to when the binomial distribution must be used in the statistical treatment of detected events. (orig.)

  13. Multivariate General Linear Models (MGLM) on Riemannian Manifolds with Applications to Statistical Analysis of Diffusion Weighted Images.

    Science.gov (United States)

    Kim, Hyunwoo J; Adluru, Nagesh; Collins, Maxwell D; Chung, Moo K; Bendlin, Barbara B; Johnson, Sterling C; Davidson, Richard J; Singh, Vikas

    2014-06-23

    Linear regression is a parametric model which is ubiquitous in scientific analysis. The classical setup where the observations and responses, i.e., ( x i , y i ) pairs, are Euclidean is well studied. The setting where y i is manifold valued is a topic of much interest, motivated by applications in shape analysis, topic modeling, and medical imaging. Recent work gives strategies for max-margin classifiers, principal components analysis, and dictionary learning on certain types of manifolds. For parametric regression specifically, results within the last year provide mechanisms to regress one real-valued parameter, x i ∈ R , against a manifold-valued variable, y i ∈ . We seek to substantially extend the operating range of such methods by deriving schemes for multivariate multiple linear regression -a manifold-valued dependent variable against multiple independent variables, i.e., f : R n → . Our variational algorithm efficiently solves for multiple geodesic bases on the manifold concurrently via gradient updates. This allows us to answer questions such as: what is the relationship of the measurement at voxel y to disease when conditioned on age and gender. We show applications to statistical analysis of diffusion weighted images, which give rise to regression tasks on the manifold GL ( n )/ O ( n ) for diffusion tensor images (DTI) and the Hilbert unit sphere for orientation distribution functions (ODF) from high angular resolution acquisition. The companion open-source code is available on nitrc.org/projects/riem_mglm.

  14. Multiple Linear Regressions by Maximizing the Likelihood under Assumption of Generalized Gauss-Laplace Distribution of the Error.

    Science.gov (United States)

    Jäntschi, Lorentz; Bálint, Donatella; Bolboacă, Sorana D

    2016-01-01

    Multiple linear regression analysis is widely used to link an outcome with predictors for better understanding of the behaviour of the outcome of interest. Usually, under the assumption that the errors follow a normal distribution, the coefficients of the model are estimated by minimizing the sum of squared deviations. A new approach based on maximum likelihood estimation is proposed for finding the coefficients on linear models with two predictors without any constrictive assumptions on the distribution of the errors. The algorithm was developed, implemented, and tested as proof-of-concept using fourteen sets of compounds by investigating the link between activity/property (as outcome) and structural feature information incorporated by molecular descriptors (as predictors). The results on real data demonstrated that in all investigated cases the power of the error is significantly different by the convenient value of two when the Gauss-Laplace distribution was used to relax the constrictive assumption of the normal distribution of the error. Therefore, the Gauss-Laplace distribution of the error could not be rejected while the hypothesis that the power of the error from Gauss-Laplace distribution is normal distributed also failed to be rejected.

  15. Poisson Growth Mixture Modeling of Intensive Longitudinal Data: An Application to Smoking Cessation Behavior

    Science.gov (United States)

    Shiyko, Mariya P.; Li, Yuelin; Rindskopf, David

    2012-01-01

    Intensive longitudinal data (ILD) have become increasingly common in the social and behavioral sciences; count variables, such as the number of daily smoked cigarettes, are frequently used outcomes in many ILD studies. We demonstrate a generalized extension of growth mixture modeling (GMM) to Poisson-distributed ILD for identifying qualitatively…

  16. The Integral Equation Method and the Neumann Problem for the Poisson Equation on NTA Domains

    Czech Academy of Sciences Publication Activity Database

    Medková, Dagmar

    2009-01-01

    Roč. 63, č. 21 (2009), s. 227-247 ISSN 0378-620X Institutional research plan: CEZ:AV0Z10190503 Keywords : Poisson equation * Neumann problem * integral equation method Subject RIV: BA - General Mathematics Impact factor: 0.477, year: 2009

  17. Which solutions of the third problem for the Poisson equation are bounded?

    Czech Academy of Sciences Publication Activity Database

    Medková, Dagmar

    -, č. 6 (2004), s. 501-510 ISSN 1085-3375 R&D Projects: GA ČR GA201/00/1515 Institutional research plan: CEZ:AV0Z1019905 Keywords : Poisson equation * Robin problem * boundedness Subject RIV: BA - General Mathematics

  18. Random vibrations of Rayleigh vibroimpact oscillator under Parametric Poisson white noise

    Science.gov (United States)

    Yang, Guidong; Xu, Wei; Jia, Wantao; He, Meijuan

    2016-04-01

    Random vibration problems for a single-degree-of-freedom (SDOF) Rayleigh vibroimpact system with a rigid barrier under parametric Poisson white noise are considered. The averaged generalized Fokker-Planck-Kolmogorov (FPK) equations with parametric Poisson white noise are derived after using the nonsmooth variable transformation and the approximate stationary solutions for the system's response are obtained by perturbation method. The results are validated numerically by using Monte Carlo simulations from original vibroimpact system. Effects on the response for different damping coefficients, restitution coefficients and noise intensities are discussed. Furthermore, stochastic bifurcations are also explored.

  19. Generalized randomly amplified linear system driven by Gaussian noises: Extreme heavy tail and algebraic correlation decay in plasma turbulence

    International Nuclear Information System (INIS)

    Steinbrecher, Gyoergy; Weyssow, B.

    2004-01-01

    The extreme heavy tail and the power-law decay of the turbulent flux correlation observed in hot magnetically confined plasmas are modeled by a system of coupled Langevin equations describing a continuous time linear randomly amplified stochastic process where the amplification factor is driven by a superposition of colored noises which, in a suitable limit, generate a fractional Brownian motion. An exact analytical formula for the power-law tail exponent β is derived. The extremely small value of the heavy tail exponent and the power-law distribution of laminar times also found experimentally are obtained, in a robust manner, for a wide range of input values, as a consequence of the (asymptotic) self-similarity property of the noise spectrum. As a by-product, a new representation of the persistent fractional Brownian motion is obtained

  20. Polynomial Solutions of the Boundary Value Problems for the Poisson Equation in a Layer

    Directory of Open Access Journals (Sweden)

    O. D. Algazin

    2017-01-01

    Full Text Available It is well known that the Dirichlet problem for the Laplace equation in a ball has a unique polynomial solution (harmonic polynomial in the case if the given boundary value is the trace of an arbitrary polynomial on the sphere. S.M.Nikol'skii generalized this result in the case of a boundary value problem of the first kind for a linear differential self-adjoint operator of the order 2l with constant coefficients (in particular polyharmonic and for a domain that is an ellipsoid in Rn. For a polyharmonic equation in a ball (homogeneous and inhomogeneous, V.V. Karachik proposed the Almansi formula-based algorithm to construct a polynomial solution of the Dirichlet problem.The paper considers the Poisson equation with the polynomial right-hand side in a multidimensional infinite layer bounded by two hyper-planes. Shows that the Dirichlet boundary value problem and the mixed Dirichlet-Neumann boundary value problem with polynomial boundary conditions have a unique solution in the class of functions of polynomial growth, and this solution is a polynomial. Gives an algorithm for constructing this polynomial solution and considers examples. In particular, presents formulas to give exact values of certain integrals (including multi-dimensional ones and sums of trigonometric series.

  1. On the FACR( l) algorithm for the discrete Poisson equation

    Science.gov (United States)

    Temperton, Clive

    1980-03-01

    Direct methods for the solution of the discrete Poisson equation over a rectangle are commonly based either on Fourier transforms or on block-cyclic reduction. The relationship between these two approaches is demonstrated explicitly, and used to derive the FACR( l) algorithm in which the Fourier transform approach is combined with l preliminary steps of cyclic reduction. It is shown that the optimum choice of l leads to an algorithm for which the operation count per mesh point is almost independent of the mesh size. Numerical results concerning timing and round-off error are presented for the N × N Dirichlet problem for various values of N and l. Extensions to more general problems, and to implementation on parallel or vector computers are briefly discussed.

  2. On the Magnetic Shield for a Vlasov-Poisson Plasma

    Science.gov (United States)

    Caprino, Silvia; Cavallaro, Guido; Marchioro, Carlo

    2017-12-01

    We study the screening of a bounded body Γ against the effect of a wind of charged particles, by means of a shield produced by a magnetic field which becomes infinite on the border of Γ . The charged wind is modeled by a Vlasov-Poisson plasma, the bounded body by a torus, and the external magnetic field is taken close to the border of Γ . We study two models: a plasma composed by different species with positive or negative charges, and finite total mass of each species, and another made of many species of the same sign, each having infinite mass. We investigate the time evolution of both systems, showing in particular that the plasma particles cannot reach the body. Finally we discuss possible extensions to more general initial data. We show also that when the magnetic lines are straight lines, (that imposes an unbounded body), the previous results can be improved.

  3. Harmonic Development of an Arbitrary Function of the Moon/Sun/Planets Coordinates to Poisson Series

    Science.gov (United States)

    Kudryavtsev, S. M.

    2005-12-01

    A new algorithm for the spectral analysis of an arbitrary function of the Moon/Sun/planets coordinates tabulated over a long period of time is proposed. Expansion of the function to a Poisson series is directly made where the amplitudes and arguments of the series' terms are high-degree time polynomials (as opposed to the classical Fourier analysis where the terms' amplitudes are constants and the arguments are linear functions of time).

  4. On a Poisson homogeneous space of bilinear forms with a Poisson-Lie action

    Science.gov (United States)

    Chekhov, L. O.; Mazzocco, M.

    2017-12-01

    Let \\mathscr A be the space of bilinear forms on C^N with defining matrices A endowed with a quadratic Poisson structure of reflection equation type. The paper begins with a short description of previous studies of the structure, and then this structure is extended to systems of bilinear forms whose dynamics is governed by the natural action A\\mapsto B ABT} of the {GL}_N Poisson-Lie group on \\mathscr A. A classification is given of all possible quadratic brackets on (B, A)\\in {GL}_N× \\mathscr A preserving the Poisson property of the action, thus endowing \\mathscr A with the structure of a Poisson homogeneous space. Besides the product Poisson structure on {GL}_N× \\mathscr A, there are two other (mutually dual) structures, which (unlike the product Poisson structure) admit reductions by the Dirac procedure to a space of bilinear forms with block upper triangular defining matrices. Further generalisations of this construction are considered, to triples (B,C, A)\\in {GL}_N× {GL}_N× \\mathscr A with the Poisson action A\\mapsto B ACT}, and it is shown that \\mathscr A then acquires the structure of a Poisson symmetric space. Generalisations to chains of transformations and to the quantum and quantum affine algebras are investigated, as well as the relations between constructions of Poisson symmetric spaces and the Poisson groupoid. Bibliography: 30 titles.

  5. PENERAPAN REGRESI BINOMIAL NEGATIF UNTUK MENGATASI OVERDISPERSI PADA REGRESI POISSON

    Directory of Open Access Journals (Sweden)

    PUTU SUSAN PRADAWATI

    2013-09-01

    Full Text Available Poisson regression was used to analyze the count data which Poisson distributed. Poisson regression analysis requires state equidispersion, in which the mean value of the response variable is equal to the value of the variance. However, there are deviations in which the value of the response variable variance is greater than the mean. This is called overdispersion. If overdispersion happens and Poisson Regression analysis is being used, then underestimated standard errors will be obtained. Negative Binomial Regression can handle overdispersion because it contains a dispersion parameter. From the simulation data which experienced overdispersion in the Poisson Regression model it was found that the Negative Binomial Regression was better than the Poisson Regression model.

  6. Simulation of non-linear ultrasound fields

    DEFF Research Database (Denmark)

    Jensen, Jørgen Arendt; Fox, Paul D.; Wilhjelm, Jens E.

    2002-01-01

    An approach for simulating non-linear ultrasound imaging using Field II has been implemented using the operator splitting approach, where diffraction, attenuation, and non-linear propagation can be handled individually. The method uses the Earnshaw/Poisson solution to Burgcrs' equation for the non...

  7. Numerical solution of large sparse linear systems

    International Nuclear Information System (INIS)

    Meurant, Gerard; Golub, Gene.

    1982-02-01

    This note is based on one of the lectures given at the 1980 CEA-EDF-INRIA Numerical Analysis Summer School whose aim is the study of large sparse linear systems. The main topics are solving least squares problems by orthogonal transformation, fast Poisson solvers and solution of sparse linear system by iterative methods with a special emphasis on preconditioned conjuguate gradient method [fr

  8. Thinning spatial point processes into Poisson processes

    DEFF Research Database (Denmark)

    Møller, Jesper; Schoenberg, Frederic Paik

    This paper describes methods for randomly thinning certain classes of spatial point processes. In the case of a Markov point process, the proposed method involves a dependent thinning of a spatial birth-and-death process, where clans of ancestors associated with the original points are identified......, and where one simulates backwards and forwards in order to obtain the thinned process. In the case of a Cox process, a simple independent thinning technique is proposed. In both cases, the thinning results in a Poisson process if and only if the true Papangelou conditional intensity is used, and thus can...... be used as a diagnostic for assessing the goodness-of-fit of a spatial point process model. Several examples, including clustered and inhibitive point processes, are considered....

  9. Thinning spatial point processes into Poisson processes

    DEFF Research Database (Denmark)

    Møller, Jesper; Schoenberg, Frederic Paik

    2010-01-01

    In this paper we describe methods for randomly thinning certain classes of spatial point processes. In the case of a Markov point process, the proposed method involves a dependent thinning of a spatial birth-and-death process, where clans of ancestors associated with the original points...... are identified, and where we simulate backwards and forwards in order to obtain the thinned process. In the case of a Cox process, a simple independent thinning technique is proposed. In both cases, the thinning results in a Poisson process if and only if the true Papangelou conditional intensity is used, and......, thus, can be used as a graphical exploratory tool for inspecting the goodness-of-fit of a spatial point process model. Several examples, including clustered and inhibitive point processes, are considered....

  10. Periodic Poisson Solver for Particle Tracking

    International Nuclear Information System (INIS)

    Dohlus, M.; Henning, C.

    2015-05-01

    A method is described to solve the Poisson problem for a three dimensional source distribution that is periodic into one direction. Perpendicular to the direction of periodicity a free space (or open) boundary is realized. In beam physics, this approach allows to calculate the space charge field of a continualized charged particle distribution with periodic pattern. The method is based on a particle mesh approach with equidistant grid and fast convolution with a Green's function. The periodic approach uses only one period of the source distribution, but a periodic extension of the Green's function. The approach is numerically efficient and allows the investigation of periodic- and pseudo-periodic structures with period lengths that are small compared to the source dimensions, for instance of laser modulated beams or of the evolution of micro bunch structures. Applications for laser modulated beams are given.

  11. Distributed Time-Varying Formation Robust Tracking for General Linear Multiagent Systems With Parameter Uncertainties and External Disturbances.

    Science.gov (United States)

    Hua, Yongzhao; Dong, Xiwang; Li, Qingdong; Ren, Zhang

    2017-05-18

    This paper investigates the time-varying formation robust tracking problems for high-order linear multiagent systems with a leader of unknown control input in the presence of heterogeneous parameter uncertainties and external disturbances. The followers need to accomplish an expected time-varying formation in the state space and track the state trajectory produced by the leader simultaneously. First, a time-varying formation robust tracking protocol with a totally distributed form is proposed utilizing the neighborhood state information. With the adaptive updating mechanism, neither any global knowledge about the communication topology nor the upper bounds of the parameter uncertainties, external disturbances and leader's unknown input are required in the proposed protocol. Then, in order to determine the control parameters, an algorithm with four steps is presented, where feasible conditions for the followers to accomplish the expected time-varying formation tracking are provided. Furthermore, based on the Lyapunov-like analysis theory, it is proved that the formation tracking error can converge to zero asymptotically. Finally, the effectiveness of the theoretical results is verified by simulation examples.

  12. Observer-based distributed adaptive fault-tolerant containment control of multi-agent systems with general linear dynamics.

    Science.gov (United States)

    Ye, Dan; Chen, Mengmeng; Li, Kui

    2017-11-01

    In this paper, we consider the distributed containment control problem of multi-agent systems with actuator bias faults based on observer method. The objective is to drive the followers into the convex hull spanned by the dynamic leaders, where the input is unknown but bounded. By constructing an observer to estimate the states and bias faults, an effective distributed adaptive fault-tolerant controller is developed. Different from the traditional method, an auxiliary controller gain is designed to deal with the unknown inputs and bias faults together. Moreover, the coupling gain can be adjusted online through the adaptive mechanism without using the global information. Furthermore, the proposed control protocol can guarantee that all the signals of the closed-loop systems are bounded and all the followers converge to the convex hull with bounded residual errors formed by the dynamic leaders. Finally, a decoupled linearized longitudinal motion model of the F-18 aircraft is used to demonstrate the effectiveness. Copyright © 2017 ISA. Published by Elsevier Ltd. All rights reserved.

  13. Methods to adjust for misclassification in the quantiles for the generalized linear model with measurement error in continuous exposures.

    Science.gov (United States)

    Wang, Ching-Yun; Tapsoba, Jean De Dieu; Duggan, Catherine; Campbell, Kristin L; McTiernan, Anne

    2016-05-10

    In many biomedical studies, covariates of interest may be measured with errors. However, frequently in a regression analysis, the quantiles of the exposure variable are often used as the covariates in the regression analysis. Because of measurement errors in the continuous exposure variable, there could be misclassification in the quantiles for the exposure variable. Misclassification in the quantiles could lead to bias estimation in the association between the exposure variable and the outcome variable. Adjustment for misclassification will be challenging when the gold standard variables are not available. In this paper, we develop two regression calibration estimators to reduce bias in effect estimation. The first estimator is normal likelihood-based. The second estimator is linearization-based, and it provides a simple and practical correction. Finite sample performance is examined via a simulation study. We apply the methods to a four-arm randomized clinical trial that tested exercise and weight loss interventions in women aged 50-75 years. Copyright © 2015 John Wiley & Sons, Ltd.

  14. Compound Poisson Approximations for Sums of Random Variables

    OpenAIRE

    Serfozo, Richard F.

    1986-01-01

    We show that a sum of dependent random variables is approximately compound Poisson when the variables are rarely nonzero and, given they are nonzero, their conditional distributions are nearly identical. We give several upper bounds on the total-variation distance between the distribution of such a sum and a compound Poisson distribution. Included is an example for Markovian occurrences of a rare event. Our bounds are consistent with those that are known for Poisson approximations for sums of...

  15. Equivalence between generalized phenomenological schemes for the interaction of cosmological fluids: applications to arbitrary linear barotropic fluids and vacuum decay

    OpenAIRE

    Maia, M. R. G.; Pires, N.; Gimenes, H. S.

    2015-01-01

    Interactions between cosmic fluids may appear in many cosmological scenarios that go far beyond the usually studied energy exchange in the dark sector. In the absence of known microscopic interaction mechanisms, phenomenological ansatzes are usually proposed in order to describe such models. In this paper, we derive a generalization of one of the most frequently used of such ansatzes:the one based on a initial proposal of Shapiro, Sol\\`a, Espa\\~na-Bonet and Ruiz-Lapuente who described a time-...

  16. On the generalization of linear least mean squares estimation to quantum systems with non-commutative outputs

    Energy Technology Data Exchange (ETDEWEB)

    Amini, Nina H. [Stanford University, Edward L. Ginzton Laboratory, Stanford, CA (United States); CNRS, Laboratoire des Signaux et Systemes (L2S) CentraleSupelec, Gif-sur-Yvette (France); Miao, Zibo; Pan, Yu; James, Matthew R. [Australian National University, ARC Centre for Quantum Computation and Communication Technology, Research School of Engineering, Canberra, ACT (Australia); Mabuchi, Hideo [Stanford University, Edward L. Ginzton Laboratory, Stanford, CA (United States)

    2015-12-15

    The purpose of this paper is to study the problem of generalizing the Belavkin-Kalman filter to the case where the classical measurement signal is replaced by a fully quantum non-commutative output signal. We formulate a least mean squares estimation problem that involves a non-commutative system as the filter processing the non-commutative output signal. We solve this estimation problem within the framework of non-commutative probability. Also, we find the necessary and sufficient conditions which make these non-commutative estimators physically realizable. These conditions are restrictive in practice. (orig.)

  17. A Note on the Large Sample Properties of Estimators Based on Generalized Linear Models for Correlated Pseudo-observations

    DEFF Research Database (Denmark)

    Jacobsen, Martin; Martinussen, Torben

    2016-01-01

    Pseudo-values have proven very useful in censored data analysis in complex settings such as multi-state models. It was originally suggested by Andersen et al., Biometrika, 90, 2003, 335 who also suggested to estimate standard errors using classical generalized estimating equation results....... These results were studied more formally in Graw et al., Lifetime Data Anal., 15, 2009, 241 that derived some key results based on a second-order von Mises expansion. However, results concerning large sample properties of estimates based on regression models for pseudo-values still seem unclear. In this paper...

  18. The Poisson model limits in NBA basketball: Complexity in team sports

    Science.gov (United States)

    Martín-González, Juan Manuel; de Saá Guerra, Yves; García-Manso, Juan Manuel; Arriaza, Enrique; Valverde-Estévez, Teresa

    2016-12-01

    Team sports are frequently studied by researchers. There is presumption that scoring in basketball is a random process and that can be described using the Poisson Model. Basketball is a collaboration-opposition sport, where the non-linear local interactions among players are reflected in the evolution of the score that ultimately determines the winner. In the NBA, the outcomes of close games are often decided in the last minute, where fouls play a main role. We examined 6130 NBA games in order to analyze the time intervals between baskets and scoring dynamics. Most numbers of baskets (n) over a time interval (ΔT) follow a Poisson distribution, but some (e.g., ΔT = 10 s, n > 3) behave as a Power Law. The Poisson distribution includes most baskets in any game, in most game situations, but in close games in the last minute, the numbers of events are distributed following a Power Law. The number of events can be adjusted by a mixture of two distributions. In close games, both teams try to maintain their advantage solely in order to reach the last minute: a completely different game. For this reason, we propose to use the Poisson model as a reference. The complex dynamics will emerge from the limits of this model.

  19. The Relationship between Spousal Age Difference and Violence against Wife in Nigeria: A Generalized Linear Modelling Approach

    Directory of Open Access Journals (Sweden)

    Anthony C. Akpanta

    2017-11-01

    Full Text Available The act of violence against wife is condemnable and attracts various legal penalties, globally. This article attempts to find a link between spousal age difference and violence (Emotional, Physical and Sexual against wives in Nigeria. The result show that wives who are older than their partners are more likely to experience sexual and emotional violence; also, wives who are same age as their husbands are more likely to experience sexual violence; whereas wives who are 1-4 years younger than their husbands are more likely to experience physical violence; while wives 5 years or more younger than their husbands are generally less likely to experience any form of violence.

  20. Quantum, classical, and hybrid QM/MM calculations in solution: General implementation of the ddCOSMO linear scaling strategy

    Energy Technology Data Exchange (ETDEWEB)

    Lipparini, Filippo, E-mail: flippari@uni-mainz.de [Sorbonne Universités, UPMC Univ. Paris 06, UMR 7598, Laboratoire Jacques-Louis Lions, F-75005 Paris (France); Sorbonne Universités, UPMC Univ. Paris 06, UMR 7616, Laboratoire de Chimie Théorique, F-75005 Paris (France); Sorbonne Universités, UPMC Univ. Paris 06, Institut du Calcul et de la Simulation, F-75005 Paris (France); Scalmani, Giovanni; Frisch, Michael J. [Gaussian, Inc., 340 Quinnipiac St. Bldg. 40, Wallingford, Connecticut 06492 (United States); Lagardère, Louis [Sorbonne Universités, UPMC Univ. Paris 06, Institut du Calcul et de la Simulation, F-75005 Paris (France); Stamm, Benjamin [Sorbonne Universités, UPMC Univ. Paris 06, UMR 7598, Laboratoire Jacques-Louis Lions, F-75005 Paris (France); CNRS, UMR 7598 and 7616, F-75005 Paris (France); Cancès, Eric [Université Paris-Est, CERMICS, Ecole des Ponts and INRIA, 6 and 8 avenue Blaise Pascal, 77455 Marne-la-Vallée Cedex 2 (France); Maday, Yvon [Sorbonne Universités, UPMC Univ. Paris 06, UMR 7598, Laboratoire Jacques-Louis Lions, F-75005 Paris (France); Institut Universitaire de France, Paris, France and Division of Applied Maths, Brown University, Providence, Rhode Island 02912 (United States); Piquemal, Jean-Philip [Sorbonne Universités, UPMC Univ. Paris 06, UMR 7616, Laboratoire de Chimie Théorique, F-75005 Paris (France); CNRS, UMR 7598 and 7616, F-75005 Paris (France); Mennucci, Benedetta [Dipartimento di Chimica e Chimica Industriale, Università di Pisa, Via Risorgimento 35, 56126 Pisa (Italy)

    2014-11-14

    We present the general theory and implementation of the Conductor-like Screening Model according to the recently developed ddCOSMO paradigm. The various quantities needed to apply ddCOSMO at different levels of theory, including quantum mechanical descriptions, are discussed in detail, with a particular focus on how to compute the integrals needed to evaluate the ddCOSMO solvation energy and its derivatives. The overall computational cost of a ddCOSMO computation is then analyzed and decomposed in the various steps: the different relative weights of such contributions are then discussed for both ddCOSMO and the fastest available alternative discretization to the COSMO equations. Finally, the scaling of the cost of the various steps with respect to the size of the solute is analyzed and discussed, showing how ddCOSMO opens significantly new possibilities when cheap or hybrid molecular mechanics/quantum mechanics methods are used to describe the solute.