WorldWideScience

Sample records for plausible alternative futures

  1. Plausible rice yield losses under future climate warming.

    Science.gov (United States)

    Zhao, Chuang; Piao, Shilong; Wang, Xuhui; Huang, Yao; Ciais, Philippe; Elliott, Joshua; Huang, Mengtian; Janssens, Ivan A; Li, Tao; Lian, Xu; Liu, Yongwen; Müller, Christoph; Peng, Shushi; Wang, Tao; Zeng, Zhenzhong; Peñuelas, Josep

    2016-12-19

    Rice is the staple food for more than 50% of the world's population(1-3). Reliable prediction of changes in rice yield is thus central for maintaining global food security. This is an extraordinary challenge. Here, we compare the sensitivity of rice yield to temperature increase derived from field warming experiments and three modelling approaches: statistical models, local crop models and global gridded crop models. Field warming experiments produce a substantial rice yield loss under warming, with an average temperature sensitivity of -5.2 ± 1.4% K(-1). Local crop models give a similar sensitivity (-6.3 ± 0.4% K(-1)), but statistical and global gridded crop models both suggest less negative impacts of warming on yields (-0.8 ± 0.3% and -2.4 ± 3.7% K(-1), respectively). Using data from field warming experiments, we further propose a conditional probability approach to constrain the large range of global gridded crop model results for the future yield changes in response to warming by the end of the century (from -1.3% to -9.3% K(-1)). The constraint implies a more negative response to warming (-8.3 ± 1.4% K(-1)) and reduces the spread of the model ensemble by 33%. This yield reduction exceeds that estimated by the International Food Policy Research Institute assessment (-4.2 to -6.4% K(-1)) (ref. 4). Our study suggests that without CO2 fertilization, effective adaptation and genetic improvement, severe rice yield losses are plausible under intensive climate warming scenarios.

  2. Choosing diverse sets of plausible scenarios in multidimensional exploratory futures techniques

    NARCIS (Netherlands)

    Lord, Steven; Helfgott, Ariella; Vervoort, Joost M.

    2016-01-01

    Abstract Morphological analysis allows any number of dimensions to be retained when framing future conditions, and techniques within morphological analysis determine which combinations of those dimensions represent plausible futures. However, even a relatively low number of dimensions in future cond

  3. What happened (and what didn't): Discourse constraints on encoding of plausible alternatives.

    Science.gov (United States)

    Fraundorf, Scott H; Benjamin, Aaron S; Watson, Duane G

    2013-10-01

    Three experiments investigated how font emphasis influences reading and remembering discourse. Although past work suggests that contrastive pitch contours benefit memory by promoting encoding of salient alternatives, it is unclear both whether this effect generalizes to other forms of linguistic prominence and how the set of alternatives is constrained. Participants read discourses in which some true propositions had salient alternatives (e.g., British scientists found the endangered monkey when the discourse also mentioned French scientists) and completed a recognition memory test. In Experiments 1 and 2, font emphasis in the initial presentation increased participants' ability to later reject false statements about salient alternatives but not about unmentioned items (e.g., Portuguese scientists). In Experiment 3, font emphasis helped reject false statements about plausible alternatives, but not about less plausible alternatives that were nevertheless established in the discourse. These results suggest readers encode a narrow set of only those alternatives plausible in the particular discourse. They also indicate that multiple manipulations of linguistic prominence, not just prosody, can lead to consideration of alternatives.

  4. Plausible futures of a social-ecological system: Yahara watershed, Wisconsin, USA

    Directory of Open Access Journals (Sweden)

    Stephen R. Carpenter

    2015-06-01

    Full Text Available Agricultural watersheds are affected by changes in climate, land use, agricultural practices, and human demand for energy, food, and water resources. In this context, we analyzed the agricultural, urbanizing Yahara watershed (size: 1345 km², population: 372,000 to assess its responses to multiple changing drivers. We measured recent trends in land use/cover and water quality of the watershed, spatial patterns of 10 ecosystem services, and spatial patterns and nestedness of governance. We developed scenarios for the future of the Yahara watershed by integrating trends and events from the global scenarios literature, perspectives of stakeholders, and models of biophysical drivers and ecosystem services. Four qualitative scenarios were created to explore plausible trajectories to the year 2070 in the watershed's social-ecological system under different regimes: no action on environmental trends, accelerated technological development, strong intervention by government, and shifting values toward sustainability. Quantitative time-series for 2010-2070 were developed for weather and land use/cover during each scenario as inputs to model changes in ecosystem services. Ultimately, our goal is to understand how changes in the social-ecological system of the Yahara watershed, including management of land and water resources, can build or impair resilience to shifting drivers, including climate.

  5. Risk, Resilience, and Alternative Futures

    DEFF Research Database (Denmark)

    Garsten, Christina; Sörbom, Adrienne

    of its work around the production of The Global Risks Report. The paper discusses the The Global Risks Report and the models of alternative futures outlined in the report, as examples of organizational scenario-building. The report draws on expertise available within the different communities...

  6. The Unprepared Discipline: Selection of Alternative Futures.

    Science.gov (United States)

    Massengale, John D.

    1988-01-01

    Physical education teachers need to create alternative futures, select the one of their choice, and then take the necessary steps to make this future come true. Background information on futurism, futures research, and ways to consider alternative futures is provided for those who wish to incorporate these concepts into the curriculum. (Author/CB)

  7. Pediatrics in the year 2020 and beyond: preparing for plausible futures.

    Science.gov (United States)

    Starmer, Amy J; Duby, John C; Slaw, Kenneth M; Edwards, Anne; Leslie, Laurel K

    2010-11-01

    Although the future of pediatrics is uncertain, the organizations that lead pediatrics, and the professionals who practice within it, have embraced the notion that the pediatric community must anticipate and lead change to ultimately improve the health of children and adolescents. In an attempt to proactively prepare for a variety of conceivable futures, the board of directors of the American Academy of Pediatrics established the Vision of Pediatrics 2020 Task Force in 2008. This group was charged to think broadly about the future of pediatrics, to gather input on key trends that are influencing the future, to create likely scenarios of the future, and to recommend strategies to best prepare pediatric clinicians and pediatric organizations for a range of potential futures. The work of this task force led to the development of 8 "megatrends" that were identified as highly likely to have a profound influence on the future of pediatrics. A separate list of "wild-card" scenarios was created of trends with the potential to have a substantial influence but are less likely to occur. The process of scenario-planning was used to consider the effects of the 8 megatrends on pediatrics in the year 2020 and beyond. Consideration of these possible scenarios affords the opportunity to determine potential future pediatric needs, to identify potential solutions to address those needs, and, ultimately, to proactively prepare the profession to thrive if these or other future scenarios become realities.

  8. Using scenario planning in public health: anticipating alternative futures.

    Science.gov (United States)

    Neiner, Jennifer A; Howze, Elizabeth H; Greaney, Mary L

    2004-01-01

    Scenario planning is a method for anticipating possible alternative futures. Used widely in business applications, it allows planners to anticipate problems, reevaluate assumptions, and reflect on consequences of those alternative futures. In this article, scenario planning is applied to public health, specifically to illustrate the four steps in scenario planning for public health using a health department's desire to address chronic disease prevention and control. An unhealthy diet and physical inactivity are considered to be key risk factors. The scenarios are presented in table format and are for illustration purposes only. Many other plausible scenarios could be constructed. Scenario planning allows stake-holders to define a desired, shared vision of the future, but more important, they can better prepare public health professionals to be successful in a constantly changing environment.

  9. Future coal production outlooks in the IPCC Emission Scenarios: Are they plausible?

    Energy Technology Data Exchange (ETDEWEB)

    Hoeoek, Mikael

    2010-10-15

    Anthropogenic climate change caused by CO{sub 2} emissions is strongly and fundamentally linked to the future energy production. The Special Report on Emission Scenarios (SRES) from 2000 contains 40 scenarios for future fossil fuel production and is used by the IPCC to assess future climate change. Coal, with its 26% share of world energy, is a major source of greenhouse gas emissions and commonly seen as a key contributor to anthropogenic climate change. SRES contains a wide array of different coal production outlooks, ranging from a complete coal phase-out by 2100 to a roughly tenfold increase from present world production levels. Scenarios with high levels of global warming also have high expectations on future fossil fuel production. The assumptions on resource availability are in SRES based on Rogner's assessment of world hydrocarbon resources from 1997, where it is stated that 'the sheer size of the fossil resource base makes fossil sources an energy supply option for many centuries to come'. Regarding the future coal production it is simply assumed to be dependent on economics, accessibility, and environmental acceptance. It is also generally assumed that coal is abundant, and will thus take a dominating part in the future energy system. Depletion, geographical location and geological parameters are not given much influence in the scenario storylines. This study quantifies what the coal production projection in SRES would imply in reality. SRES is riddled with future production projections that would put unreasonable expectation on just a few countries or regions. Is it reasonable to expect that China, among the world's largest coal reserve and resource holder and producer, would increase their production by a factor of 8 over the next 90 years, as implied by certain scenarios? Can massive increases in global coal output really be justified from historical trends or will reality rule out some production outlooks as implausible? The

  10. A Flexible Socioeconomic Scenarios Framework for the Study of Plausible Arctic Futures

    Science.gov (United States)

    Reissell, A. K.; Peters, G. P.; Riahi, K.; Kroglund, M.; Lovecraft, A. L.; Nilsson, A. E.; Preston, B. L.; van Ruijven, B. J.

    2016-12-01

    Future developments of the Arctic region are associated with different drivers of change - climate, environmental, and socio-economic - and their interactions, and are highly uncertain. The uncertainty poses challenges for decision-making, calling for development of new analytical frameworks. Scenarios - coherent narratives describing potential futures, pathways to futures, and drivers of change along the way - can be used to explore the consequences of the key uncertainties, particularly in the long-term. In a participatory scenarios workshop, we used both top-down and bottom-up approaches for the development of a flexible socioeconomic scenarios framework. The top-down approach was linked to the global Integrated Assessment Modeling framework and its Shared Socio-Economic Pathways (SSPs), developing an Arctic extension of the set of five storylines on the main socioeconomic uncertainties in global climate change research. The bottom-up approach included participatory development of narratives originating from within the Arctic region. For extension of global SSPs to the regional level, we compared the key elements in the global SSPs (Population, Human Development, Economy & Lifestyle, Policies & Institutions, Technology, and Environment & Natural Resources) and key elements in the Arctic. Additional key elements for the Arctic scenarios include, for example, seasonal migration, the large role of traditional knowledge and culture, mixed economy, nested governance structure, human and environmental security, quality of infrastructure. The bottom-up derived results suggested that the scenarios developed independent of the SSPs could be mapped back to the SSPs to demonstrate consistency with respect to representing similar boundary conditions. The two approaches are complimentary, as the top-down approach can be used to set the global socio-economic and climate boundary conditions, and the bottom-up approach providing the regional context. One key uncertainty and

  11. Charting plausible futures for diabetes prevalence in the United States: a role for system dynamics simulation modeling.

    Science.gov (United States)

    Milstein, Bobby; Jones, Andrew; Homer, Jack B; Murphy, Dara; Essien, Joyce; Seville, Don

    2007-07-01

    Healthy People 2010 (HP 2010) objectives call for a 38% reduction in the prevalence of diagnosed diabetes mellitus, type 1 and type 2, by the year 2010. The process for setting this objective, however, did not focus on the achievability or the compatibility of this objective with other national public health objectives. We used a dynamic simulation model to explore plausible trajectories for diabetes prevalence in the wake of rising levels of obesity in the U.S. population. The model helps to interpret historic trends in diabetes prevalence in the United States and to anticipate plausible future trends through 2010. We conducted simulation experiments using a computer model of diabetes population dynamics to 1) track the rates at which people develop diabetes, are diagnosed with the disease, and die, and 2) assess the effects of various preventive-care interventions. System dynamics modeling methodology based on data from multiple sources guided the analyses. With the number of new cases of diabetes being much greater than the number of deaths among those with the disease, the prevalence of diagnosed diabetes in the United States is likely to continue to increase. Even a 29% reduction in the number of new cases (the HP 2010 objective) would only slow the growth, not reverse it. Increased diabetes detection rates or decreased mortality rates--also HP 2010 objectives--would further increase diagnosed prevalence. The HP 2010 objective for reducing diabetes prevalence is unattainable given the historical processes that are affecting incidence, diagnosis, and mortality, and even a zero-growth future is unlikely. System dynamics modeling shows why interventions to protect against chronic diseases have only gradual effects on their diagnosed prevalence.

  12. Alternatives for Future Waste Management in Denmark

    DEFF Research Database (Denmark)

    Møller Andersen, Frits; Cimpan, Ciprian; Dall, Ole

    The TOPWASTE project has addressed the challenges of planning robust solutions for future waste management. The purpose was to identify economic and environmentally optimal solutions ‐ taking into account different scenarios for the development of the surrounding systems, such as the energy system....... During the project, four decision support tools were developed:1. Frida ‐ The EPA's tool for forecasting future waste generation 2. OptiWaste ‐ a new tool for economic optimisation of investments and operation of the combined waste and energy system3. KISS ‐ a new lifecycle based model with focus...... on comparison of greenhouse gas emissions associated with different waste management alternatives 4. A new tool for techno‐economic modelling of central sorting plants. The project has furthermore contributed with method development on evaluation of critical resources as well as analyses of economic...

  13. Assessing the Sensitivity of a Reservoir Management System Under Plausible Assumptions About Future Climate Over Seasons to Decades

    Science.gov (United States)

    Ward, M. N.; Brown, C. M.; Baroang, K. M.; Kaheil, Y. H.

    2011-12-01

    We illustrate an analysis procedure that explores the robustness and overall productivity of a reservoir management system under plausible assumptions about climate fluctuation and change. Results are presented based on a stylized version of a multi-use reservoir management model adapted from Angat Dam, Philippines. It represents a modest-sized seasonal storage reservoir in a climate with a pronounced dry season. The reservoir management model focuses on October-March, during which climatological inflow declines due to the arrival of the dry season, and reservoir management becomes critical and challenging. Inflow is assumed to be impacted by climate fluctuations representing interannal variation (white noise), decadal to multidecadal variation (MDV, here represented by a stochastic autoregressive process) and global change (GC), here represented by a systematic linear trend in seasonal inflow total over the simulation period of 2008-2047. Reservoir reliability, and risk of extreme persistent water shortfall, is assessed under different combinations and magnitudes of GC and MDV. We include an illustration of adaptive management, using seasonal forecasts and updated climate normals. A set of seasonal forecast and observed inflow values are generated for 2008-2047 by randomly rearranging the forecast-observed pairs for 1968-2007. Then, trends are imposed on the observed series, with differing assumptions about the extent to which the seasonal forecasts can be expected to track the trend. We consider the framework presented here well-suited to providing insights about managing the climate risks in reservoir operations, providing guidance on expected benefits and risks of different strategies and climate scenarios.

  14. Alternative Energy Development and China's Energy Future

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Nina; Fridley, David

    2011-06-15

    In addition to promoting energy efficiency, China has actively pursued alternative energy development as a strategy to reduce its energy demand and carbon emissions. One area of particular focus has been to raise the share of alternative energy in China’s rapidly growing electricity generation with a 2020 target of 15% share of total primary energy. Over the last ten years, China has established several major renewable energy regulations along with programs and subsidies to encourage the growth of non-fossil alternative energy including solar, wind, nuclear, hydro, geothermal and biomass power as well as biofuels and coal alternatives. This study thus seeks to examine China’s alternative energy in terms of what has and will continue to drive alternative energy development in China as well as analyze in depth the growth potential and challenges facing each specific technology. This study found that despite recent policies enabling extraordinary capacity and investment growth, alternative energy technologies face constraints and barriers to growth. For relatively new technologies that have not achieved commercialization such as concentrated solar thermal, geothermal and biomass power, China faces technological limitations to expanding the scale of installed capacity. While some alternative technologies such as hydropower and coal alternatives have been slowed by uneven and often changing market and policy support, others such as wind and solar PV have encountered physical and institutional barriers to grid integration. Lastly, all alternative energy technologies face constraints in human resources and raw material resources including land and water, with some facing supply limitations in critical elements such as uranium for nuclear, neodymium for wind and rare earth metals for advanced solar PV. In light of China’s potential for and barriers to growth, the resource and energy requirement for alternative energy technologies were modeled and scenario analysis

  15. Classification and plausibility assessment of historical and future weather and climate anomalies (application for the Wupper River Basin, Germany)

    Science.gov (United States)

    Scheibel, Marc; Lorza, Paula

    2017-04-01

    In the frame of the Horizon 2020 project BINGO (Bringing INnovation to onGOing water management), the effects of climate change scenarios on the water cycle in the Wupper River Basin are being currently investigated. The Wupper catchment area is prone to flash floods in summer, winter floods as well as dry periods. The occurrence of these events has increased in the last decades together with the shifting of the rainy season. BINGO approach focuses on, among others: a) identifying past weather extremes and anomalies due to climate change; and b) gaining deeper knowledge on the effects of soil moisture on water balance and runoff generation processes for reservoir management and enhancement of Wupper Association's flood early warning system. Historical hydro-meteorological extreme events are assessed based on daily records of long-term precipitation time series (ca. 80 years) as well as precipitation time series from downscaled reanalysis products (i.e., ERA-Interim). The determination of representative indices, e.g., Weather Extremity Index (WEI) or the Standardized Precipitation Index (SPI) serves to compensate for uncertainties in spatial and temporal recording of the parameters of individual processes. The WEI establishes the highest rainfall amount per station and its rarity, the extent of the affected area, and the event duration. For the evaluation of historical climate signals in the reference period and for the assessment of future scenarios, deviation of the mean monthly observed precipitation from the long-term mean value is determined as a first approach for several stations along the catchment area for individual months and different time scales. As a second approach, different indices such as SPI and SPEI (Standardized Precipitation Evapotranspiration Index) are calculated for different time scales in order to determine whether they were anomalously dry or wet. SPEI is more suitable for climate change analysis than SPI since the former considers not

  16. Anticipating and Communicating Plausible Environmental and Health Concerns Associated with Future Disasters: The ShakeOut and ARkStorm Scenarios as Examples

    Science.gov (United States)

    Plumlee, G. S.; Morman, S. A.; Alpers, C. N.; Hoefen, T. M.; Meeker, G. P.

    2010-12-01

    toward a more quantitative, predictive approach to understanding the potential sources, types, environmental behavior, and health implications of HM predicted to result from these disaster scenarios. Although only a first step, this qualitative approach will help enhance planning for, mitigation of, and resilience to environmental-health consequences of future disasters. This qualitative approach also requires careful communication to stakeholders that does not sensationalize or overstate potential problems, but rather conveys plausible impacts and next steps to improve understanding of potential risks and their mitigation.

  17. Alternative Educational Futures for a Knowledge Society

    Science.gov (United States)

    Young, Michael

    2010-01-01

    This article offers a critical analysis of recent trends in educational policy with particular reference to their assumptions about the knowledge society. It examines the implications of the analysis for the issue of elitism and the promotion of greater educational equality. The article concludes by offering an alternative approach to educational…

  18. From provocative narrative scenarios to quantitative biophysical model results: Simulating plausible futures to 2070 in an urbanizing agricultural watershed in Wisconsin, USA

    Science.gov (United States)

    Booth, E.; Chen, X.; Motew, M.; Qiu, J.; Zipper, S. C.; Carpenter, S. R.; Kucharik, C. J.; Steven, L. I.

    2015-12-01

    Scenario analysis is a powerful tool for envisioning future social-ecological change and its consequences on human well-being. Scenarios that integrate qualitative storylines and quantitative biophysical models can create a vivid picture of these potential futures but the integration process is not straightforward. We present - using the Yahara Watershed in southern Wisconsin (USA) as a case study - a method for developing quantitative inputs (climate, land use/cover, and land management) to drive a biophysical modeling suite based on four provocative and contrasting narrative scenarios that describe plausible futures of the watershed to 2070. The modeling suite consists of an agroecosystem model (AgroIBIS-VSF), hydrologic routing model (THMB), and empirical lake water quality model and estimates several biophysical indicators to evaluate the watershed system under each scenario. These indicators include water supply, lake flooding, agricultural production, and lake water quality. Climate (daily precipitation and air temperature) for each scenario was determined using statistics from 210 different downscaled future climate projections for two 20-year time periods (2046-2065 and 2081-2100) and modified using a stochastic weather generator to allow flexibility for matching specific climate events within the scenario narratives. Land use/cover for each scenario was determined first by quantifying changes in areal extent every decade for 15 categories at the watershed scale to be consistent with the storyline events and theme. Next, these changes were spatially distributed using a rule-based framework based on land suitability metrics that determine transition probabilities. Finally, agricultural inputs including manure and fertilizer application rates were determined for each scenario based on the prevalence of livestock, water quality regulations, and technological innovations. Each scenario is compared using model inputs (maps and time-series of land use/cover and

  19. Adult Education and the Invention of Alternative Futures

    Science.gov (United States)

    Dator, James

    1975-01-01

    The guest editor introduces a six-article feature on alternative relationships between futures studies and adult education by discussing education as a futures-oriented activity, revealing questions inherent in futurism, recounting its development as a discipline, and stating the adult educator's special obligation to foster discussion of…

  20. Looking for plausibility

    CERN Document Server

    Abdullah, Wan Ahmad Tajuddin Wan

    2010-01-01

    In the interpretation of experimental data, one is actually looking for plausible explanations. We look for a measure of plausibility, with which we can compare different possible explanations, and which can be combined when there are different sets of data. This is contrasted to the conventional measure for probabilities as well as to the proposed measure of possibilities. We define what characteristics this measure of plausibility should have. In getting to the conception of this measure, we explore the relation of plausibility to abductive reasoning, and to Bayesian probabilities. We also compare with the Dempster-Schaefer theory of evidence, which also has its own definition for plausibility. Abduction can be associated with biconditionality in inference rules, and this provides a platform to relate to the Collins-Michalski theory of plausibility. Finally, using a formalism for wiring logic onto Hopfield neural networks, we ask if this is relevant in obtaining this measure.

  1. Comprehensive evaluation of future site alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Shain, D.I.; Jones, M.E.; Ryan, K.

    1994-04-01

    Due to rapid changes occurring within the Nuclear Weapons complex, the need for integrated planning designed to combine multiple program needs into one strategic plan has become a necessity. This is more apparent as diverse DOE programs compete for dwindling resources. These programs range from traditional production operations, environmental and waste management, to facility transition, economic development, decontamination and decommissioning, and environmental restoration activities. Each program can influence another, thus increasing the difficulty of distinguishing program elements. The method in developing comprehensive plans becomes even more complicated when environmental compliance issues, regulatory agreements and stakeholder values are considered. AT the Department of Energy`s (DOE) Rocky Flats Plant (RFP), all of these program conditions exist. This paper addresses a set of tools which are being developed at RFP that provides key planning elements and alternatives assessment for the DOE`s Office of Planning and Integration (OPI) and National Environmental Policy Act (NEPA) Compliance Officer at RFP. This set of tools is referred to as the Systems Engineering Analysis (SEA).

  2. Challenges in Renewable Natural Resources: A Guide to Alternative Futures.

    Science.gov (United States)

    Theobald, Robert

    First presented at a United States Department of Agriculture (USDA) conference on renewable resources, this material includes information and discussion on critical issues, policies, and future alternatives for natural resources in the United States. (CO)

  3. Anticipating Alternative Futures for the Platform Economy

    Directory of Open Access Journals (Sweden)

    Mikko Dufva

    2017-09-01

    Full Text Available Despite the considerable hype around platforms, our understanding of what the platform economy means and what drivers will define future development trajectories is limited. Companies and policy makers have a great need to investigate what potential opportunities will arise from the platform economy. A shared perception of uncertainties and a strong vision are prerequisites for the development of the platform economy. In this article, we describe a systematic way to develop a resilient vision for a new platform ecosystem, both from the viewpoint of national policy makers and corporate strategy makers in the heavy engineering industry. The process uses morphological analysis for scenario development and robust portfolio modelling for creating resilient strategies. The results include a list of key uncertainties, three general scenarios (sustainable development by Europe; polarization driven by China and the United States; US-driven fast, unreliable growth as well as steel-industry specific scenarios based on these uncertainties, elements of a resilient vision, and strategies for coping with the uncertainties described by the scenarios.

  4. The impact of alternate fuels on future candidate automotive engines

    Energy Technology Data Exchange (ETDEWEB)

    Rahnke, C.J.; Nichols, R.J.

    1982-06-01

    The thermal efficiency that could occur in the future for a variety of automotive engine candidates operating on conventional and alternate fuels is projected based on current automotive engine development trends and the special characteristics of the various alternate fuels. The multi-fuel engine candidates include mixture cycle and direct injection reciprocating engines, as well as adiabatic turbocompound engines and advanced gas turbine and Stirling engines. The alternate fuels considered are propane, methanol, ethanol, diesel and methane.

  5. Alternate Futures for 2025. Security Planning to Avoid Surprise.

    Science.gov (United States)

    1996-09-01

    of advancing concepts related to national defense. The views expressed in this report are those of the authors and do not reflect the official policy ...the mission, the program, or the adoption of the technology. This publication has been reviewed by security and policy review authorities, is...then enriched the worlds by" backcasting " from 2025 to 1996 to build plausible histories. After finishing the plausible histories, the team added to

  6. Alternative future scenarios for the SPS comparative assessment

    Energy Technology Data Exchange (ETDEWEB)

    Ayres, R.U.; Ridker, R.G.; Watson, W.D. Jr.; Arnold, J.; Tayi, G.

    1980-08-01

    The objective of the comparative assessment is to develop an initial understanding of the SPS with respect to a limited set of energy alternatives. A comparative methodology report describes the multi-step process in the comparative assessment. The first step is the selection and characterization of alternative energy systems. Terrestrial alternatives are selected, and their cost, performance, and environmental and social attributes are specified for use in the comparison with the SPS in the post-2000 era. Data on alternative technologies were sought from previous research and from other comparisons. The object of this study is to provide a futures framework for evaluating SPS (i.e., factor prices, primary energy prices, and energy demands for the US from 1980 to 2030). The economic/energy interactions are discussed, and a number of specific modelling schemes that have been used for long-range forecasting purposes are described. This discussion provides the rationale for the choice of a specific model and methodology, which is described. Long-range cost assumptions used in the forecast are detailed, and the basis for the selection of specific scenarios follows. Results of the analysis are detailed. (WHK)

  7. Future energy demand in Laos. Scenario alternatives for development

    Energy Technology Data Exchange (ETDEWEB)

    Luukkanen, J.; Kouphokham, K.; Panula-Ontto, J. [and others

    2012-07-01

    Energy production in Laos is still dominated by traditional fuels. Fuelwood in the main source of energy and most of the energy is consumed at households for cooking. Increase in the number of cars and motorbikes is rapidly increasing the use of imported petroleum products. Electrification is one of the central targets of the Lao government. The electrification rate has increased fast in Laos and in the year 2010 over 70 % households had electricity supply. The target is to have 90 % access to electricity by the year 2020. The World Bank regards the electrification of Lao PDR to be a success story. This paper deals with the present and future energy consumption in Laos. First the historical trends of energy use in different sectors are analysed. The future scenarios are constructed using LaoLinda model. Four different future alternative development paths are analysed using the model results. The energy use data source for the analysis is from the Ministry of Energy and Mines (MEM) of Lao PDR. Economic and other data is from the Department of Statistics of Lao PDR.

  8. Alternative futures for the Department of Energy National Laboratories

    Energy Technology Data Exchange (ETDEWEB)

    1995-02-01

    This Task Force was asked to propose alternate futures for the Department of Energy laboratories noted in the report. The authors` intensive ten months` study revealed multiple missions and sub-missions--traditional missions and new missions--programs and projects--each with factors of merit. They respectively suggest that the essence of what the Department, and particularly the laboratories, should and do stand for: the energy agenda. Under the overarching energy agenda--the labs serving the energy opportunities--they comment on their national security role, the all important energy role, all related environmental roles, the science and engineering underpinning for all the above, a focused economic role, and conclude with governance/organization change recommendations.

  9. Alternatives to animal testing: current status and future perspectives.

    Science.gov (United States)

    Liebsch, Manfred; Grune, Barbara; Seiler, Andrea; Butzke, Daniel; Oelgeschläger, Michael; Pirow, Ralph; Adler, Sarah; Riebeling, Christian; Luch, Andreas

    2011-08-01

    On the occasion of the 20th anniversary of the Center for Alternative Methods to Animal Experiments (ZEBET), an international symposium was held at the German Federal Institute for Risk Assessment (BfR) in Berlin. At the same time, this symposium was meant to celebrate the 50th anniversary of the publication of the book "The Principles of Humane Experimental Technique" by Russell and Burch in 1959 in which the 3Rs principle (that is, Replacement, Reduction, and Refinement) has been coined and introduced to foster the development of alternative methods to animal testing. Another topic addressed by the symposium was the new vision on "Toxicology in the twenty-first Century", as proposed by the US-National Research Council, which aims at using human cells and tissues for toxicity testing in vitro rather than live animals. An overview of the achievements and current tasks, as well as a vision of the future to be addressed by ZEBET@BfR in the years to come is outlined in the present paper.

  10. The chaperone-like activity of α-synuclein attenuates aggregation of its alternatively spliced isoform, 112-synuclein in vitro: plausible cross-talk between isoforms in protein aggregation.

    Science.gov (United States)

    Manda, Krishna Madhuri; Yedlapudi, Deepthi; Korukonda, Srikanth; Bojja, Sreedhar; Kalivendi, Shasi V

    2014-01-01

    Abnormal oligomerization and aggregation of α-synuclein (α-syn/WT-syn) has been shown to be a precipitating factor in the pathophysiology of Parkinson's disease (PD). Earlier observations on the induced-alternative splicing of α-syn by Parkinsonism mimetics as well as identification of region specific abnormalities in the transcript levels of 112-synuclein (112-syn) in diseased subjects underscores the role of 112-syn in the pathophysiology of PD. In the present study, we sought to identify the aggregation potential of 112-syn in the presence or absence of WT-syn to predict its plausible role in protein aggregation events. Results demonstrate that unlike WT-syn, lack of 28 aa in the C-terminus results in the loss of chaperone-like activity with a concomitant gain in vulnerability to heat-induced aggregation and time-dependent fibrillation. The effects were dose and time-dependent and a significant aggregation of 112-syn was evident at as low as 45 °C following 10 min of incubation. The heat-induced aggregates were found to be ill-defined structures and weakly positive towards Thioflavin-T (ThT) staining as compared to clearly distinguishable ThT positive extended fibrils resulting upon 24 h of incubation at 37 °C. Further, the chaperone-like activity of WT-syn significantly attenuated heat-induced aggregation of 112-syn in a dose and time-dependent manner. On contrary, WT-syn synergistically enhanced fibrillation of 112-syn. Overall, the present findings highlight a plausible cross-talk between isoforms of α-syn and the relative abundance of these isoforms may dictate the nature and fate of protein aggregates.

  11. Visualizing alternative phosphorus scenarios for future food security

    Directory of Open Access Journals (Sweden)

    Tina-Simone Neset

    2016-10-01

    Full Text Available The impact of global phosphorus scarcity on food security has increasingly been the focus of scientific studies over the past decade. However, systematic analyses of alternative futures for phosphorus supply and demand throughout the food system are still rare and provide limited inclusion of key stakeholders. Addressing global phosphorus scarcity requires an integrated approach exploring potential demand reduction as well as recycling opportunities. This implies recovering phosphorus from multiple sources, such as food waste, manure and excreta, as well as exploring novel opportunities to reduce the long-term demand for phosphorus in food production such as changing diets. Presently, there is a lack of stakeholder and scientific consensus around priority measures. To therefore enable exploration of multiple pathways and facilitate a stakeholder dialogue on the technical, behavioral and institutional changes required to meet long-term future phosphorus demand, this paper introduces an interactive web-based tool, designed for visualizing global phosphorus scenarios in real-time. The interactive global phosphorus scenario tool builds on several demand and supply side measures that can be selected and manipulated interactively by the user. It provides a platform to facilitate stakeholder dialogue to plan for a soft landing and identify a suite of concrete priority options, such as investing in agricultural phosphorus use efficiency, or renewable fertilizers derived from phosphorus recovered from wastewater and food waste, to determine how phosphorus demand to meet future food security could be attained on a global scale in 2040 and 2070. This paper presents four example scenarios, including (1 the potential of full recovery of human excreta, (2 the challenge of a potential increase in non-food phosphorus demand, (3 the potential of a decreased animal product consumption, and (4 the potential decrease in phosphorus demand from increased efficiency

  12. Visualizing Alternative Phosphorus Scenarios for Future Food Security.

    Science.gov (United States)

    Neset, Tina-Simone; Cordell, Dana; Mohr, Steve; VanRiper, Froggi; White, Stuart

    2016-01-01

    The impact of global phosphorus scarcity on food security has increasingly been the focus of scientific studies over the past decade. However, systematic analyses of alternative futures for phosphorus supply and demand throughout the food system are still rare and provide limited inclusion of key stakeholders. Addressing global phosphorus scarcity requires an integrated approach exploring potential demand reduction as well as recycling opportunities. This implies recovering phosphorus from multiple sources, such as food waste, manure, and excreta, as well as exploring novel opportunities to reduce the long-term demand for phosphorus in food production such as changing diets. Presently, there is a lack of stakeholder and scientific consensus around priority measures. To therefore enable exploration of multiple pathways and facilitate a stakeholder dialog on the technical, behavioral, and institutional changes required to meet long-term future phosphorus demand, this paper introduces an interactive web-based tool, designed for visualizing global phosphorus scenarios in real time. The interactive global phosphorus scenario tool builds on several demand and supply side measures that can be selected and manipulated interactively by the user. It provides a platform to facilitate stakeholder dialog to plan for a soft landing and identify a suite of concrete priority options, such as investing in agricultural phosphorus use efficiency, or renewable fertilizers derived from phosphorus recovered from wastewater and food waste, to determine how phosphorus demand to meet future food security could be attained on a global scale in 2040 and 2070. This paper presents four example scenarios, including (1) the potential of full recovery of human excreta, (2) the challenge of a potential increase in non-food phosphorus demand, (3) the potential of decreased animal product consumption, and (4) the potential decrease in phosphorus demand from increased efficiency and yield gains in

  13. Public Alternative Schools and the Future of Democracy.

    Science.gov (United States)

    Nathan, Joe; Kohl, Herbert

    1981-01-01

    The authors take issue with Mary Anne Raywid's article on public alternative schools in the April 1981 "Kappan." Specifically, they address the "myths" concerning student veto power, evaluation, impetus for developing alternative schools, and the effects of federal money. (WD)

  14. Unconventional Pn wave tomography of the Western Mediterranean region and the Gulf of Cadiz. Constraints on plausible locations of major future and past historical earthquakes.

    Science.gov (United States)

    Beghoul, Noureddine; Mezioud-Saich, Amira; Said Oucherif, Mohamed

    2017-04-01

    remarkable tectonic feature, trending roughly East-West and extending from off-the Apennines coast, in the Tyrrhenian Sea, up to the Gulf of Cadiz. A continuous increase in Pn velocity from 7.6 km/s up to 8.3 km/s is observed. At the Gulf of Cadiz a very well delineated arc of high velocity of 8.3 km/s, represents the cold shadow of the underthrusted oceanic slab beneath the Gibraltar Arc. This imaged regional tectonic feature strongly supports the delamination of an underthrusted East dipping oceanic slab, beneath the Mediterranean Sea (Thiebot and Gutscher; Gutscher et al., 2006). (b) all 228 crustal earthquakes of magnitudes larger or equal to 5.5 which occurred since 1964, are not randomly distributed, but are located above cold mantle lid ( 7.9 km/s), and associated to large variations in Pn velocities at their immediate vicinities (heterogeneities, patches etc.). The 1755 Lisbon earthquake (Mag8.5-9.0), as well as future large earthquakes, could be further constrained using the results obtained by this mantle lid mapping.

  15. Alternatives Reality: What to Expect from Future Allocations

    Science.gov (United States)

    Sedlacek, Verne O.

    2014-01-01

    For well more than a decade, the "endowment model" of investing has been synonymous with increasing allocations to alternative investment strategies, defined largely as hedge funds, private real estate, private equity and venture capital and other, generally less liquid or illiquid strategies compared to public markets. This trend…

  16. Local alternative energy futures: developing economies/building communities

    Energy Technology Data Exchange (ETDEWEB)

    Totten, M.; Glass, B.; Freedberg, M.; Webb, L.

    1980-12-01

    A separate abstract was prepared for each of the three parts of the conference. A sufficient range of information is presented to enable interested parties to explore the viable alternatives for community self-sufficiency. The parts are entitled: Financial Incentives and Funding Sources; Standards, Regulations, Mandates, Ordinances, Covenants; and Community/Economic Development. (MCW)

  17. Using critical evaluation to reappraise plausibility judgments: A critical cognitive component of conceptual change

    Science.gov (United States)

    Lombardi, D.

    2011-12-01

    data support a hypothesis and its alternatives. The presentation will focus on how instruction promoting critical evaluation can encourage individuals to reappraise their plausibility judgments and initiate knowledge reconstruction. In a recent pilot study, teachers experienced an instructional scaffold promoting critical evaluation of two competing climate change theories (i.e., human-induced and increasing solar irradiance) and significantly changed both their plausibility judgments and perceptions of correctness toward the scientifically-accepted model of human-induced climate change. A comparison group of teachers who did not experience the critical evaluation activity showed no significant change. The implications of these studies for future research and instruction will be discussed in the presentation, including effective ways to increase students' and teachers' ability to be critically evaluative and reappraise their plausibility judgments. With controversial science issues, such as climate change, such abilities may be necessary to facilitate conceptual change.

  18. The Third Way and beyond: Criticisms, futures and alternatives

    OpenAIRE

    2004-01-01

    The Third Way is said to be the guiding philosophy for New Labour and centre-left parties and governments across the globe. Moving beyond attempts to define and defend the Third Way, this innovative collection embarks on a critical examination of this key concept. The editors draw on expert contributions from a range of disciplines and perspectives to dissect the Third Way in theory and in practice, assess its legacy and suggest alternatives. The book begins by reviewing attempts to define th...

  19. Alternate approaches to future electron-positron linear colliders

    Energy Technology Data Exchange (ETDEWEB)

    Loew, G.A. [Stanford Univ., CA (United States). Stanford Linear Accelerator Center

    1998-07-01

    The purpose of this article is two-fold: to review the current international status of various design approaches to the next generation of e{sup +}e{sup {minus}} linear colliders, and on the occasion of his 80th birthday, to celebrate Richard B. Neal`s many contributions to the field of linear accelerators. As it turns out, combining these two tasks is a rather natural enterprise because of Neal`s long professional involvement and insight into many of the problems and options which the international e{sup +}e{sup {minus}} linear collider community is currently studying to achieve a practical design for a future machine.

  20. Control of Avian Coccidiosis: Future and Present Natural Alternatives

    Directory of Open Access Journals (Sweden)

    Rosa Estela Quiroz-Castañeda

    2015-01-01

    Full Text Available Numerous efforts to date have been implemented in the control of avian coccidiosis caused by the Eimeria parasite. Since the appearance of anticoccidial chemical compounds, the search for new alternatives continues. Today, no product is available to cope with the disease; however, the number of products commercially available is constantly increasing. In this review, we focus on natural products and their anticoccidial activity. This group comprises fatty acids, antioxidants, fungal and herbal extracts, and immune response modulators with proven anticoccidial activity, many of which exist as dietary supplements. Additionally, we offer an overview of the poultry industry and the economic cost of coccidiosis as well as the classical strategies used to control the disease.

  1. Control of avian coccidiosis: future and present natural alternatives.

    Science.gov (United States)

    Quiroz-Castañeda, Rosa Estela; Dantán-González, Edgar

    2015-01-01

    Numerous efforts to date have been implemented in the control of avian coccidiosis caused by the Eimeria parasite. Since the appearance of anticoccidial chemical compounds, the search for new alternatives continues. Today, no product is available to cope with the disease; however, the number of products commercially available is constantly increasing. In this review, we focus on natural products and their anticoccidial activity. This group comprises fatty acids, antioxidants, fungal and herbal extracts, and immune response modulators with proven anticoccidial activity, many of which exist as dietary supplements. Additionally, we offer an overview of the poultry industry and the economic cost of coccidiosis as well as the classical strategies used to control the disease.

  2. Alternative futures for health economics: implications for nursing management.

    Science.gov (United States)

    Mannion, Russell; Small, Neil; Thompson, Carl

    2005-09-01

    As nursing has been subject to successive waves of 'managerialism' there has been a drive on the part of government and elements within the profession to enhance the science base and promote cost-effective health care interventions. This has generated new interest in the 'economics of nursing' as efficiency and 'value for money' are viewed as necessary precondition for the provision of a high quality nursing service. As an academic subject health economics has brought an elegant set of theories to bear on the topic of health and health care. However, mainstream health economics is premised on a series of simplifying assumptions that, if applied uncritically, can induce a range of unintended and adverse consequences. This paper asks how ideas developed in one sphere (health economics) can be become influential in another (nursing management and practice) and it seeks explanations in the theories of Michel Foucault, specifically in his exploration of the reciprocal relationship between power and knowledge. How are our assumptions about what is possible and desirable shaped, how far do mechanisms of surveillance and self-subjugation extend? A range of alternative economic approaches have been developed which challenge many mainstream health economics assumptions. Some of these are better suited to the complex social environment present within health care. Nurses, nurse managers and researchers should question the assumptions of dominant economic models and explore a range of economic frameworks when planning services and evaluating their practice.

  3. Time for action: science education for an alternative future

    Science.gov (United States)

    Hodson, Derek

    2003-06-01

    Following a brief historical survey of the popular 'slogans' that have influenced science education during the past quarter century and a review of current international debate on scientific literacy and science pedagogy, the author takes the view that while much of value has been achieved, there is still considerable cause for concern and that it is time for action in two senses. First, it is time to take action on the school science curriculum because it no longer meets the needs, interests and aspirations of young citizens. Second, it is time for a science curriculum oriented toward sociopolitical action. The author argues that if current social and environmental problems are to be solved, we need a generation of scientifically and politically literate citizens who are not content with the role of 'armchair critic'. A particular concern in North America is the link between science education, economic globalization, increasing production and unlimited expansion - a link that threatens the freedom of individuals, the spiritual well-being of particular societies and the very future of the planet. The author's response is to advocate a politicized, issues-based curriculum focused on seven areas of concern (human health; food and agriculture; land, water and mineral resources; energy resources and consumption; industry; information transfer and transportation; ethics and social responsibility) and addressed at four levels of sophistication, culminating in preparation for sociopolitical action. The curriculum proposal outlined in the article is intended to produce activists: people who will fight for what is right, good and just; people who will work to re-fashion society along more socially-just lines; people who will work vigorously in the best interests of the biosphere. At the heart of this curriculum is a commitment to pursue a fundamental realignment of the values underpinning Western industrialized society. Achieving that goal is a formidable task - one that

  4. Biodiversity consequences of alternative future land use scenarios in Greater Yellowstone.

    Science.gov (United States)

    Gude, Patricia H; Hansen, Andrew J; Jones, Danielle A

    2007-06-01

    Land use is rapidly expanding in the Greater Yellowstone Ecosystem, primarily from growth in the number of rural homes. There is a need to project possible future land use and assess impacts on nature reserves as a guide to future management. We assessed the potential biodiversity impacts of alternative future land use scenarios in the Greater Yellowstone Ecosystem. An existing regression-based simulation model was used to project three alternative scenarios of future rural home development. The spatial patterns of forecasted development were then compared to several biodiversity response variables that included cover types, species habitats, and biodiversity indices. We identified the four biodiversity responses most at risk of exurban development, designed growth management policies to protect these areas, and tested their effectiveness in two alternative future scenarios. We found that the measured biodiversity responses, including riparian habitat, elk winter range, migration corridors, and eight other land cover, habitat, and biodiversity indices, are likely to undergo substantial conversion (between 5% and 40%) to exurban development by 2020. Future habitat conversion to exurban development outside the region's nature reserves is likely to impact wildlife populations within the reserves. Existing growth management policies will provide minimal protection to biodiversity in this region. We identified specific growth management policies, including incentives to cluster future growth near towns, that can protect "at risk" habitat types without limiting overall growth in housing.

  5. Visions of Alternative (Unpredictable Futures and Their Use in Policy Analysis

    Directory of Open Access Journals (Sweden)

    Robert Costanza

    2000-07-01

    Full Text Available The most critical task facing humanity today is the creation of a shared vision of a sustainable and desirable society, one that can provide permanent prosperity within the biophysical constraints of the real world in a way that is fair and equitable to all of humanity, to other species, and to future generations. Recent work with businesses and communities indicates that creating a shared vision is the most effective engine for change in the desired direction, yet most effort in "futures modeling" has focused on extrapolating past trends rather than envisioning alternative futures. Science and economics as applied to policy are in conflict more often over alternative visions of the world than purely "scientific" disagreements. Likewise, governance has gotten bogged down in mediating short term conflicts between special interests rather than its more basic role of creating broadly shared visions that can guide dispute resolution. This paper addresses the question of what policies are most appropriate for society now, given alternative visions of the future and the enormous uncertainty about the reality of the assumptions underlying these visions. Four specific visions are laid out as being representative of the major alternatives. For each vision the benefits of achieving the vision, the assumptions that would have to be true in order for it to be achieved, and the implications of it being attempted but not achieved are explored. It is argued that dealing with uncertainty about the nature of the world, its carrying capacity for humans, the impacts of climate change, and other aspects of its future can best be done at this level of future visions and assumptions, not at more detailed levels (like the parameter uncertainty in models. Application of this vision/uncertainty analysis can help us both to design the future society we want and to maximize the chances of our getting there safely.

  6. Consequences for welfare and pension buffers of alternative methods of discounting future pensions

    NARCIS (Netherlands)

    A. Bucciol; R.M.W.J. Beetsma

    2011-01-01

    We explore the implications of alternative methods of discounting future pension outlays for the valuation of funded pension liabilities. Measured liabilities affect the asset-liability ratio of pension funds and, thereby, their policies. Our framework for analysis is an applied many-generation OLG

  7. Classification using sparse representations: a biologically plausible approach.

    Science.gov (United States)

    Spratling, M W

    2014-02-01

    Representing signals as linear combinations of basis vectors sparsely selected from an overcomplete dictionary has proven to be advantageous for many applications in pattern recognition, machine learning, signal processing, and computer vision. While this approach was originally inspired by insights into cortical information processing, biologically plausible approaches have been limited to exploring the functionality of early sensory processing in the brain, while more practical applications have employed non-biologically plausible sparse coding algorithms. Here, a biologically plausible algorithm is proposed that can be applied to practical problems. This algorithm is evaluated using standard benchmark tasks in the domain of pattern classification, and its performance is compared to a wide range of alternative algorithms that are widely used in signal and image processing. The results show that for the classification tasks performed here, the proposed method is competitive with the best of the alternative algorithms that have been evaluated. This demonstrates that classification using sparse representations can be performed in a neurally plausible manner, and hence, that this mechanism of classification might be exploited by the brain.

  8. Analysis and Assessment of Impacts on Biodiversity: Investigating Alternative Futures for the California Mojave Desert

    Science.gov (United States)

    2004-07-01

    development. That probability surface is the mechanism for creating alternative futures. In brief, the research team needed to “populate” the California...McKenzie, N. L., L. Belbin , C. R. Margules and G. J. Keighery. 1989. Selecting representative reserve systems in remote areas: A case study in the...Process consultation: its role in organization development. Addison- Wesley Publishing Company, Reading, Massachusetts, USA. Scott, J. M., B. Csuti

  9. Choosing an electrical energy future for the Pacific Northwest: an alternative scenario

    Energy Technology Data Exchange (ETDEWEB)

    Beers, J.R.; Cavanagh, R.C.; Lash, T.R.; Mott, L.

    1980-05-19

    A strategy is presented for averting the short-term energy supply uncertainties that undermine prospects for stable economic development in the Pacific Northwest. This strategy is based on: an analysis of the present electric power consumption by various end-use sectors; comparison of incentives to promote energy conservation and lower demand growth; analysis of alternatives to current dependency on hydro power; and a study of the cost of planning and implementing future power supply programs. (LCL)

  10. An Integrated Conceptual Framework for Adapting Forest Management Practices to Alternative Futures

    Directory of Open Access Journals (Sweden)

    Tony Prato

    2014-01-01

    Full Text Available This paper proposes an integrated, conceptual framework that forest managers can use to simulate the multiple objectives/indicators of sustainability for different spatial patterns of forest management practices under alternative futures, rank feasible (affordable treatment patterns for forested areas, and determine if and when it is advantageous to adapt or change the spatial pattern over time for each alternative future. The latter is defined in terms of three drivers: economic growth; land use policy; and climate change. Four forest management objectives are used to demonstrate the framework, minimizing wildfire risk and water pollution and maximizing expected net return from timber sales and the extent of potential wildlife habitat. The fuzzy technique for preference by similarity to the ideal solution is used to rank the feasible spatial patterns for each subperiod in a planning horizon and alternative future. The resulting rankings for subperiods are used in a passive adaptive management procedure to determine if and when it is advantageous to adapt the spatial pattern over subperiods. One of the objectives proposed for the conceptual framework is simulated for the period 2010–2059, namely, wildfire risk, as measured by expected residential losses from wildfire in the wildland-urban interface for Flathead County, Montana.

  11. The biogas: a future energy alternative; Biogas: a alternativa energetica do futuro

    Energy Technology Data Exchange (ETDEWEB)

    Paixao, Carla Marques [Faculdade de Tecnologia e Ciencias, Salvador, BA (Brazil)]. E-mail: paixao_cm@yahoo.com.br; Anjos, Jose Angelo Sebastiao Araujo dos [Universidade de Salvador, BA (Brazil). Lab. de Pesquisa Ambiental e Geotecnologias (LAGEO)]. E-mail: jangello@unifacs.br; Mascarenhas, Artur Jose Santos [Universidade Federal da Bahia (UFBA), Salvador, BA (Brazil)]. E-mail: ajsmascarenhas@yahoo.com.br

    2006-01-15

    The biogas is one of the principal factors. During the last years the biogas use are intensifying himself which can make the energy alternative of the future. The methane, present in these gas, can be converted into energy, for his combustion generates a large quantity of thermal energy, which can be concerted into electrical ou mechanical energy. Being so, it is important that we aware that the caloric power of the biogas varies between 5000 to 7000 kcal/m{sup 3}, depending on the methane concentrations. Besides, the biogas purification through the removal of the carbonic gas can rising his calorific to values larger than 8700 kcal/m{sup 3}.

  12. What can we learn from Plausible Values?

    Science.gov (United States)

    Marsman, Maarten; Maris, Gunter; Bechger, Timo; Glas, Cees

    2016-06-01

    In this paper, we show that the marginal distribution of plausible values is a consistent estimator of the true latent variable distribution, and, furthermore, that convergence is monotone in an embedding in which the number of items tends to infinity. We use this result to clarify some of the misconceptions that exist about plausible values, and also show how they can be used in the analyses of educational surveys.

  13. Choosing an electrical energy future for the Pacific Northwest: an Alternative Scenario

    Energy Technology Data Exchange (ETDEWEB)

    Cavanagh, R.C.; Mott, L.; Beers, J.R.; Lash, T.L.

    1980-08-01

    An Alternative Scenario for the electric energy future of the Pacific Northwest is presented. The Scenario includes an analysis of each major end use of electricity in the residential, commercial, manufacturing, and agricultural sectors. This approach affords the most direct means of projecting the likely long-term growth in consumption and the opportunities for increasing the efficiency with which electricity is used in each instance. The total demand for electricity by these end uses then provides a basis for determining whether additional central station generation is required to 1995. A projection of total demand for electricity depends on the combination of many independent variables and assumptions. Thus, the approach is a resilient one; no single assumption or set of linked assumptions dominates the analysis. End-use analysis allows policymakers to visualize the benefits of alternative programs, and to make comparison with the findings of other studies. It differs from the traditional load forecasts for the Pacific Northwest, which until recently were based largely on straightforward extrapolations of historical trends in the growth of electrical demand. The Scenario addresses the supply potential of alternative energy sources. Data are compiled for 1975, 1985, and 1995 in each end-use sector.

  14. Families of Plausible Solutions to the Puzzle of Boyajian's Star

    CERN Document Server

    Wright, Jason T

    2016-01-01

    Good explanations for the unusual light curve of Boyajian's Star have been hard to find. Recent results by Montet & Simon lend strength and plausibility to the conclusion of Schaefer that in addition to short-term dimmings, the star also experiences large, secular decreases in brightness on decadal timescales. This, combined with a lack of long-wavelength excess in the star's spectral energy distribution, strongly constrains scenarios involving circumstellar material, including hypotheses invoking a spherical cloud of artifacts. We show that the timings of the deepest dimmings appear consistent with being randomly distributed, and that the star's reddening and narrow sodium absorption is consistent with the total, long-term dimming observed. Following Montet & Simon's encouragement to generate alternative hypotheses, we attempt to circumscribe the space of possible explanations with a range of plausibilities, including: a cloud in the outer solar system, structure in the ISM, natural and artificial ma...

  15. Putting watershed restoration in context: alternative future scenarios influence management outcomes.

    Science.gov (United States)

    Fullerton, A H; Steel, E A; Caras, Y; Sheer, M; Olson, P; Kaje, J

    2009-01-01

    Predicting effects of habitat restoration is an important step for recovery of imperiled anadromous salmonid populations. Habitat above three major hydropower dams in the Lewis River watershed, southwestern Washington, USA, will soon become accessible to anadromous fish. We used multiple models to estimate habitat conditions above dams and fish population responses. Additionally, we used scenario planning to predict how habitat and fish will respond to potential future trends in land use due to human population growth and riparian conservation policies. Finally, we developed a hypothetical management strategy (i.e., a set of prioritized restoration projects in specific locations within the watershed) as an example of how a fixed amount of restoration funds might be spent to enhance the success of reintroducing fish above dams. We then compared predicted outcomes from this new strategy to those of six previously modeled strategies. We estimated how the choice of the best management strategy might differ among alternative future scenarios. Results suggest that dam passage will provide access to large amounts of high-quality habitat that will benefit fish populations. Moreover, conservation of existing riparian areas, if implemented, has the potential to improve conditions to a much greater extent than restoration strategies examined, despite expected urban growth. We found that the relative performance of management strategies shifted when fish were allowed to migrate above dams, but less so among alternative futures examined. We discuss how predicted outcomes from these seven hypothetical management strategies could be used for developing an on-the-ground strategy to address a real management situation.

  16. Plausibility functions and exact frequentist inference

    CERN Document Server

    Martin, Ryan

    2012-01-01

    In the frequentist program, inferential methods with exact control on error rates are a primary focus. Methods based on asymptotic distribution theory may not be suitable in a particular problem, in which case, a numerical method is needed. This paper presents a general, Monte Carlo-driven framework for the construction of frequentist procedures based on plausibility functions. It is proved that the suitably defined plausibility function-based tests and confidence regions have desired frequentist properties. Moreover, in an important special case involving likelihood ratios, conditions are given such that the plausibility function behaves asymptotically like a consistent Bayesian posterior distribution. An extension of the proposed method is also given for the case where nuisance parameters are present. A number of examples are given which illustrate the method and demonstrate its strong performance compared to other popular existing methods.

  17. Bisimulation for Single-Agent Plausibility Models

    DEFF Research Database (Denmark)

    Andersen, Mikkel Birkegaard; Bolander, Thomas; van Ditmarsch, H.;

    2013-01-01

    Epistemic plausibility models are Kripke models agents use to reason about the knowledge and beliefs of themselves and each other. Restricting ourselves to the single-agent case, we determine when such models are indistinguishable in the logical language containing conditional belief, i.e., we...... define a proper notion of bisimulation, and prove that bisimulation corresponds to logical equivalence on image-finite models. We relate our results to other epistemic notions, such as safe belief and degrees of belief. Our results imply that there are only finitely many non-bisimilar single......-agent epistemic plausibility models on a finite set of propositions. This gives decidability for single-agent epistemic plausibility planning....

  18. A Workplace Incivility Roadmap: Identifying Theoretical Speedbumps and Alternative Routes for Future Research.

    Science.gov (United States)

    Miner, Kathi N; Diaz, Ismael; Wooderson, R Linden; McDonald, Jennifer N; Smittick, Amber L; Lomeli, Laura C

    2017-07-27

    Andersson and Pearson's (1999) seminal article on workplace incivility has paved the way for nearly two decades of research focusing on rude and discourteous behavior at work. We now have a better understanding of the dynamics associated with uncivil workplace interactions including the characteristics of those who instigate and are targeted with workplace incivility, the negative consequences of incivility, the mechanisms that link incivility and negative outcomes, and the boundary conditions that affect these relationships. The present article provides a "roadmap" for workplace incivility researchers by identifying five assumptions that we propose are acting as "speedbumps" in current workplace incivility research by limiting advancements about what workplace incivility is and how it functions. We then introduce five "alternative routes" for future workplace incivility research based on these identifications. Our goal is to guide and accelerate research toward a more nuanced understanding of workplace incivility as behavior that occurs within an organizational system. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  19. Anticipations for future of the virtual higher education towards an alternative knowledge society

    Directory of Open Access Journals (Sweden)

    Beatriz Fainholc

    2014-06-01

    Full Text Available Building an alternative knowledge society in the digital culture and in the information society, apart from representing a social, cultural and moral challenge for general as well as virtual education, entails reaching a consensus and deciding on the purpose and the reason for the formative processes of an "unknown society”, which should be built for being one of the richest social organizations in historical terms, but which arises questioning and seems to lack an “ethical compass”. Because of this, the proposals should be comprehensive and relational. They depend on the generation and development of more and more virtual scenes, where the university formative and electronic forces have to be the protagonists of a "creative synthesis". A flexible (redesign of their structures will rescue strengths and overcome weaknesses towards an unknown future. What is in the dark will be solved by a new theoretical and methodological framework used in socio-political decision-making as well as a reflective and proactive management, which will be essential to change into a new and alternative knowledge society. 

  20. SURVEYS ON THE EXPECTATIONS AND ALTERNATIVES FOR THE FUTURE OF THE EXECUTIVE WORK

    Directory of Open Access Journals (Sweden)

    Daniela Degani

    2012-06-01

    Full Text Available Many cultural and behavioral changes have occurred in society in recent years, but with little consequence in the corporate labor relations. Despite the great technological evolution, we work mostly in the same way as a century ago. This study conducts surveys about the expectations and alternatives for the future of executive work and aims to assess the benefits and prerequisites for the adoption of differentiated working relationships to reconcile the interests of professionals, organizations and society. The methods used were a quantitative survey with executives and in-depth interviews with experts. The main conclusions were that the executive work will undergo profound changes in the near future, being the main difference the flexibility of times and places to work, creating greater autonomy and demanding from professionals and companies a new level of motivation, discipline, communication skills where there is no physical presence, clarity of purpose and values. This transformation will be gradual and the companies that come forward in the adoption of processes and competences that support differentiated relationships will gain competitive advantage.

  1. Biologically Plausible, Human-scale Knowledge Representation

    Science.gov (United States)

    Crawford, Eric; Gingerich, Matthew; Eliasmith, Chris

    2016-01-01

    Several approaches to implementing symbol-like representations in neurally plausible models have been proposed. These approaches include binding through synchrony (Shastri & Ajjanagadde, 1993), "mesh" binding (van der Velde & de Kamps, 2006), and conjunctive binding (Smolensky, 1990). Recent theoretical work has suggested that…

  2. Transformative Learning for a Sustainable Future: An Exploration of Pedagogies for Change at an Alternative College

    Directory of Open Access Journals (Sweden)

    Joanna Blake

    2013-12-01

    Full Text Available Educators and policy makers have long recognised the central role that education can play in creating a more sustainable and equitable world. Yet some question whether current processes across mainstream higher education prepare learners sufficiently to graduate with the capabilities or motivation to shape and create a future that is life-sustaining. This paper presents findings from a qualitative research project carried out by Plymouth University in association with Schumacher College, Devon, UK. Schumacher College is an alternative, civil society college, owned by the Dartington Hall Trust that claims to provide transformative learning opportunities within a broad context of sustainability. The study explored the nature and application of transformative learning as a pedagogical approach to advance change towards sustainability. If learners claimed transformational learning experiences, the research asked whether, and to what extent, this transformation could be attributed to the pedagogies employed at the College. The paper begins by setting out the broad background to the relationship between marginal and mainstream educational settings, and definitions and theoretical underpinnings of transformative learning, and then leads into the research design and findings. The potential for transformative pedagogies to be applied to and employed within the wider higher education (HE sector is then discussed, and the overall findings and conclusions are presented.

  3. Alternative futures: Fields, boundaries, and divergent professionalisation strategies within the Chiropractic profession.

    Science.gov (United States)

    Brosnan, Caragh

    2017-08-19

    Sociological studies of the complementary and alternative medicine (CAM) occupations have documented the professionalisation strategies these groups use to establish boundaries between themselves and their competitors, including seeking educational accreditation and statutory regulation/licensure. Chiropractic has been particularly successful at professionalising and in Australia and the UK it is taught within public universities. Recent events have threatened chiropractic's university foothold, however, showing that professionalisation needs to be understood as an ongoing process of negotiation. Based on interviews with chiropractors in Australia and the UK, this paper examines the professionalisation strategies deployed by chiropractors within and outside of the university. Highly divergent strategies are identified across different sectors of the profession, relating to defining the chiropractic paradigm, directing education and constructing professional identity. In each domain, chiropractic academics tended to prioritise building the evidence base and becoming more aligned with medicine and other allied health professions. Although some practitioners supported this agenda, others strove to preserve chiropractic's vitalistic philosophy and professional distinction. Following Bourdieu, these intra-professional struggles are interpreted as occurring within a field in which chiropractors compete for different forms of capital, pulled by two opposing poles. The differing orientations and strategies pursued at the two poles of the field point to a number of possible futures for this CAM profession, including a potential split within the profession itself. Copyright © 2017 Elsevier Ltd. All rights reserved.

  4. Alternative future analysis for assessing the potential impact of climate change on urban landscape dynamics.

    Science.gov (United States)

    He, Chunyang; Zhao, Yuanyuan; Huang, Qingxu; Zhang, Qiaofeng; Zhang, Da

    2015-11-01

    Assessing the impact of climate change on urban landscape dynamics (ULD) is the foundation for adapting to climate change and maintaining urban landscape sustainability. This paper demonstrates an alternative future analysis by coupling a system dynamics (SD) and a cellular automata (CA) model. The potential impact of different climate change scenarios on ULD from 2009 to 2030 was simulated and evaluated in the Beijing-Tianjin-Tangshan megalopolis cluster area (BTT-MCA). The results suggested that the integrated model, which combines the advantages of the SD and CA model, has the strengths of spatial quantification and flexibility. Meanwhile, the results showed that the influence of climate change would become more severe over time. In 2030, the potential urban area affected by climate change will be 343.60-1260.66 km(2) (5.55 -20.37 % of the total urban area, projected by the no-climate-change-effect scenario). Therefore, the effects of climate change should not be neglected when designing and managing urban landscape.

  5. Plausible scenarios for the radiography profession in Sweden in 2025.

    Science.gov (United States)

    Björkman, B; Fridell, K; Tavakol Olofsson, P

    2017-11-01

    Radiography is a healthcare speciality with many technical challenges. Advances in engineering and information technology applications may continue to drive and be driven by radiographers. The world of diagnostic imaging is changing rapidly and radiographers must be proactive in order to survive. To ensure sustainable development, organisations have to identify future opportunities and threats in a timely manner and incorporate them into their strategic planning. Hence, the aim of this study was to analyse and describe plausible scenarios for the radiography profession in 2025. The study has a qualitative design with an inductive approach based on focus group interviews. The interviews were inspired by the Scenario-Planning method. Of the seven trends identified in a previous study, the radiographers considered two as the most uncertain scenarios that would have the greatest impact on the profession should they occur. These trends, labelled "Access to career advancement" and "A sufficient number of radiographers", were inserted into the scenario cross. The resulting four plausible future scenarios were: The happy radiographer, the specialist radiographer, the dying profession and the assembly line. It is suggested that "The dying profession" scenario could probably be turned in the opposite direction by facilitating career development opportunities for radiographers within the profession. Changing the direction would probably lead to a profession composed of "happy radiographers" who are specialists, proud of their profession and competent to carry out advanced tasks, in contrast to being solely occupied by "the assembly line". Copyright © 2017 The College of Radiographers. Published by Elsevier Ltd. All rights reserved.

  6. Renewable (alternative) energies. Theoretical potentials, realistic future of the energy supply; Erneuerbare (alternative) Energien. Theoretische Potentiale, reale Zukunft der Energieversorgung

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, K.H. [Hochschule fuer Technik Suedwestfalen (Germany)]|[Institut fuer Technologie- und Wissenstransfer an der Hochschulabteilung Soest (Germany); Giber, J. [TU Budapest (Hungary). Inst. fuer Atomphysik

    2007-07-01

    The depletion of fossil fuels and the accumulation of greenhouse gases, whose effects are already making themselves felt, are impacting not only on technical but also on societal and political developments around the globe. The human demand for energy from fossil fuels is growing worldwide, and the depletion of these reserves can already be clearly perceived. This is incidentally also true of nuclear fuels, at least for those reserves that are exploitable with currently available technology. The use of renewable energies such as wind power, solar energy, geothermal energy, hydropower and biomass - to name just a few - appears at present to offer a solution to the future problems relating to energy supply and environment (global warming and follow-on effects). The technologies required for this are already well-advanced today. Over a period of several years the authors have collected data and facts on global energy scenarios, evaluated countless studies, studied the technologies required for tapping renewable energy potentials and performed their own calculations on the topic.

  7. Anatomically Plausible Surface Alignment and Reconstruction

    DEFF Research Database (Denmark)

    Paulsen, Rasmus R.; Larsen, Rasmus

    2010-01-01

    With the increasing clinical use of 3D surface scanners, there is a need for accurate and reliable algorithms that can produce anatomically plausible surfaces. In this paper, a combined method for surface alignment and reconstruction is proposed. It is based on an implicit surface representation...... combined with a Markov Random Field regularisation method. Conceptually, the method maintains an implicit ideal description of the sought surface. This implicit surface is iteratively updated by realigning the input point sets and Markov Random Field regularisation. The regularisation is based on a prior...... energy that has earlier proved to be particularly well suited for human surface scans. The method has been tested on full cranial scans of ten test subjects and on several scans of the outer human ear....

  8. Neural networks, nativism, and the plausibility of constructivism.

    Science.gov (United States)

    Quartz, S R

    1993-09-01

    Recent interest in PDP (parallel distributed processing) models is due in part to the widely held belief that they challenge many of the assumptions of classical cognitive science. In the domain of language acquisition, for example, there has been much interest in the claim that PDP models might undermine nativism. Related arguments based on PDP learning have also been given against Fodor's anti-constructivist position--a position that has contributed to the widespread dismissal of constructivism. A limitation of many of the claims regarding PDP learning, however, is that the principles underlying this learning have not been rigorously characterized. In this paper, I examine PDP models from within the framework of Valiant's PAC (probably approximately correct) model of learning, now the dominant model in machine learning, and which applies naturally to neural network learning. From this perspective, I evaluate the implications of PDP models for nativism and Fodor's influential anti-constructivist position. In particular, I demonstrate that, contrary to a number of claims, PDP models are nativist in a robust sense. I also demonstrate that PDP models actually serve as a good illustration of Fodor's anti-constructivist position. While these results may at first suggest that neural network models in general are incapable of the sort of concept acquisition that is required to refute Fodor's anti-constructivist position, I suggest that there is an alternative form of neural network learning that demonstrates the plausibility of constructivism. This alternative form of learning is a natural interpretation of the constructivist position in terms of neural network learning, as it employs learning algorithms that incorporate the addition of structure in addition to weight modification schemes. By demonstrating that there is a natural and plausible interpretation of constructivism in terms of neural network learning, the position that nativism is the only plausible model of

  9. The Role of Plausible Values in Large-Scale Surveys

    Science.gov (United States)

    Wu, Margaret

    2005-01-01

    In large-scale assessment programs such as NAEP, TIMSS and PISA, students' achievement data sets provided for secondary analysts contain so-called "plausible values." Plausible values are multiple imputations of the unobservable latent achievement for each student. In this article it has been shown how plausible values are used to: (1) address…

  10. Comprehending Conflicting Science-Related Texts: Graphs as Plausibility Cues

    Science.gov (United States)

    Isberner, Maj-Britt; Richter, Tobias; Maier, Johanna; Knuth-Herzig, Katja; Horz, Holger; Schnotz, Wolfgang

    2013-01-01

    When reading conflicting science-related texts, readers may attend to cues which allow them to assess plausibility. One such plausibility cue is the use of graphs in the texts, which are regarded as typical of "hard science." The goal of our study was to investigate the effects of the presence of graphs on the perceived plausibility and…

  11. Invariant visual object recognition: biologically plausible approaches.

    Science.gov (United States)

    Robinson, Leigh; Rolls, Edmund T

    2015-10-01

    Key properties of inferior temporal cortex neurons are described, and then, the biological plausibility of two leading approaches to invariant visual object recognition in the ventral visual system is assessed to investigate whether they account for these properties. Experiment 1 shows that VisNet performs object classification with random exemplars comparably to HMAX, except that the final layer C neurons of HMAX have a very non-sparse representation (unlike that in the brain) that provides little information in the single-neuron responses about the object class. Experiment 2 shows that VisNet forms invariant representations when trained with different views of each object, whereas HMAX performs poorly when assessed with a biologically plausible pattern association network, as HMAX has no mechanism to learn view invariance. Experiment 3 shows that VisNet neurons do not respond to scrambled images of faces, and thus encode shape information. HMAX neurons responded with similarly high rates to the unscrambled and scrambled faces, indicating that low-level features including texture may be relevant to HMAX performance. Experiment 4 shows that VisNet can learn to recognize objects even when the view provided by the object changes catastrophically as it transforms, whereas HMAX has no learning mechanism in its S-C hierarchy that provides for view-invariant learning. This highlights some requirements for the neurobiological mechanisms of high-level vision, and how some different approaches perform, in order to help understand the fundamental underlying principles of invariant visual object recognition in the ventral visual stream.

  12. Futurism in the Education of the Deaf: Directions and Alternatives for the 80's.

    Science.gov (United States)

    Marshall, William J. A.

    The author presents a rationale for the study of futurism in education and analyzes the effects of significant future changes upon deaf education in the 80s. The roles that change agents play in influencing the permanence of innovations within the school are examined: advocacy, information sharing, and organizational development training.…

  13. Plausible Explanation of Quantization of Intrinsic Redshift from Hall Effect and Weyl Quantization

    Directory of Open Access Journals (Sweden)

    Smarandache F.

    2006-10-01

    Full Text Available Using phion condensate model as described by Moffat [1], we consider a plausible explanation of (Tifft intrinsic redshift quantization as described by Bell [6] as result of Hall effect in rotating frame. We also discuss another alternative to explain redshift quantization from the viewpoint of Weyl quantization, which could yield Bohr- Sommerfeld quantization.

  14. Complementary and alternative cancer therapies: past, present and the future scenario.

    Science.gov (United States)

    Shukla, Yogeshwer; Pal, Sanjoy Kumar

    2004-01-01

    Use of complementary and alternative therapies is widespread among cancer patients. Throughout the world cancer patients try many questionable or unproven treatment methods. The reasons for adopting these therapies are complex and are related to the social and cultural contexts of their geographical locations. In case of severe illness, the desire to leave no stone unturned is a powerful motivator. In developing countries, ignorance, socioeconomics, and inadequate access to mainstream medical facilities are major factors that play an important role for patients opting for alternative therapies that are replacements for mainstream treatment. Whereas in developed countries a significant proportion of cancer patients try complementary therapies as adjuncts to mainstream care for management of symptoms and to improve quality of life. Many alternative therapies, including pharmacological and biological treatments, remain highly controversial but at the same time are very popular. Evidence from randomized trial supports the value of hypnosis for cancer pain and nausea; relaxation therapy and massage for anxiety; and acupuncture for nausea. This article reviews the different popular alternative cancer therapies practiced in India and neighboring south east Asian countries to project the current international scenario on complementary and alternative cancer therapies.

  15. Challenges and potentials in using alternative landscape futures during climate change: A literature review and survey study

    Directory of Open Access Journals (Sweden)

    Amin Rastandeh

    2015-12-01

    Full Text Available This study focuses on the feasibility of applying alternative futures and scenario analysis in landscape planning during climate change to provide a wider perspective and deeper understanding of this approach for better use and more effective application in the future. The study consists of a literature review and an analysis of recent applied projects carried out worldwide. In addition, an electronic survey was conducted from March to September 2014 to examine viewpoints on the use and application of this approach with reference to climate-change impacts. The survey participants were a group of highly experienced researchers from eighteen countries involved in at least one applied project since 2000 relating to this topic. After analysis of more than forty applied projects, the survey results were incorporated into the analysis to create a comprehensive picture regarding the potentials and limitations of alternative futures and scenario analysis in landscape planning with particular attention to climate change. The findings show that this method is one of the most effective decision-making approaches for adopting landscape policies where landscapes change rapidly under the pressure of urbanisation and climate change. Nevertheless, there is a gap between the advances offered by the approach in various dimensions and the complexity of patterns, uncertainties and upheavals in landscapes due to climate-change impacts in the urbanising world. The research indicates that the approach opens up a great opportunity for decision-makers to expand their perspective and adopt appropriate landscape policies before reaching a point of no return from the sustainability point of view. Meanwhile, there are challenges and barriers in the application of alternative futures and scenario analysis for envisioning the landscapes influenced by climate change and urbanisation that should be pushed back. Although informative, this research raises new questions about this

  16. A System Analysis for Determining Alternative Technological Issues for the Future

    Science.gov (United States)

    Magistrale, V. J.; Small, J.

    1967-01-01

    A systems engineering methodology is provided, by which future technological ventures may be examined utilizing particular national, corporate, or individual value judgments. Three matrix analyses are presented. The first matrix is concerned with the effect of technology on population increase, war, poverty, health, resources, and prejudice. The second matrix explores an analytical technique for determining the relative importance of different areas of technology. The third matrix explores how an individual or corporate entity may determine how its capability may be used for future technological opportunities. No conclusions are presented since primary effort has been placed on the methodology of determining future technological issues.

  17. Future high school teachers' difficulties and alternatives found to planning electromagnetism activities designed for visual handicapped students

    Directory of Open Access Journals (Sweden)

    Eder Pires de Camargo

    2007-03-01

    Full Text Available We report here partial outcomes of a study aimed to verify future High School teachers' performance when, during the development of a called "Teaching Practice" undergraduate course, were asked to plan, elaborate and teach, in classroom situations, electromagnetism topics to a students class which included visual handicapped pupils. Data analyzed show that the main difficulties presented by the future Physics High School teachers are related to the approach to know physics phenomena as dependent of vision and to break with some elements of the traditional pedagogy. By other hand, as alternatives, future teachers showed creativity in order to surpass passive aptitudes related to this educational problem, working out methodological strategies deprived of the relation knowing/seeing, as well as, the work with orality in a physics education context.

  18. Complementary and Alternative Medicine in Rural Communities: Current Research and Future Directions

    Science.gov (United States)

    Wardle, Jon; Lui, Chi-Wai; Adams, Jon

    2012-01-01

    Contexts: The consumption of complementary and alternative medicine (CAM) in rural areas is a significant contemporary health care issue. An understanding of CAM use in rural health can provide a new perspective on health beliefs and practice as well as on some of the core service delivery issues facing rural health care generally. Purpose: This…

  19. THE FUTURE OF MOTOR TRANSPORT – ALTERNATIVE FUEL AND CANCEROGENIC SAFETY

    Directory of Open Access Journals (Sweden)

    Kanilo, P.

    2012-06-01

    Full Text Available Prospects of application of synthetic hydrocarbonic motor fuels and hydrogen as the basic and additional energy carriers are analysed. It is shown that the use of alternative fuels does not only effectively replaces oil fuel, but also provides essential decrease of environmental contamination by supertoxic substancses, namely cancerogenic and mutagen.

  20. Complementary and Alternative Medicine in Rural Communities: Current Research and Future Directions

    Science.gov (United States)

    Wardle, Jon; Lui, Chi-Wai; Adams, Jon

    2012-01-01

    Contexts: The consumption of complementary and alternative medicine (CAM) in rural areas is a significant contemporary health care issue. An understanding of CAM use in rural health can provide a new perspective on health beliefs and practice as well as on some of the core service delivery issues facing rural health care generally. Purpose: This…

  1. Greenhouse gas emissions from alternative futures of deforestation and agricultural management in the southern Amazon.

    Science.gov (United States)

    Galford, Gillian L; Melillo, Jerry M; Kicklighter, David W; Cronin, Timothy W; Cerri, Carlos E P; Mustard, John F; Cerri, Carlos C

    2010-11-16

    The Brazilian Amazon is one of the most rapidly developing agricultural areas in the world and represents a potentially large future source of greenhouse gases from land clearing and subsequent agricultural management. In an integrated approach, we estimate the greenhouse gas dynamics of natural ecosystems and agricultural ecosystems after clearing in the context of a future climate. We examine scenarios of deforestation and postclearing land use to estimate the future (2006-2050) impacts on carbon dioxide (CO(2)), methane (CH(4)), and nitrous oxide (N(2)O) emissions from the agricultural frontier state of Mato Grosso, using a process-based biogeochemistry model, the Terrestrial Ecosystems Model (TEM). We estimate a net emission of greenhouse gases from Mato Grosso, ranging from 2.8 to 15.9 Pg CO(2)-equivalents (CO(2)-e) from 2006 to 2050. Deforestation is the largest source of greenhouse gas emissions over this period, but land uses following clearing account for a substantial portion (24-49%) of the net greenhouse gas budget. Due to land-cover and land-use change, there is a small foregone carbon sequestration of 0.2-0.4 Pg CO(2)-e by natural forests and cerrado between 2006 and 2050. Both deforestation and future land-use management play important roles in the net greenhouse gas emissions of this frontier, suggesting that both should be considered in emissions policies. We find that avoided deforestation remains the best strategy for minimizing future greenhouse gas emissions from Mato Grosso.

  2. Plausibility and evidence: the case of homeopathy.

    Science.gov (United States)

    Rutten, Lex; Mathie, Robert T; Fisher, Peter; Goossens, Maria; van Wassenhoven, Michel

    2013-08-01

    Homeopathy is controversial and hotly debated. The conclusions of systematic reviews of randomised controlled trials of homeopathy vary from 'comparable to conventional medicine' to 'no evidence of effects beyond placebo'. It is claimed that homeopathy conflicts with scientific laws and that homoeopaths reject the naturalistic outlook, but no evidence has been cited. We are homeopathic physicians and researchers who do not reject the scientific outlook; we believe that examination of the prior beliefs underlying this enduring stand-off can advance the debate. We show that interpretations of the same set of evidence--for homeopathy and for conventional medicine--can diverge. Prior disbelief in homeopathy is rooted in the perceived implausibility of any conceivable mechanism of action. Using the 'crossword analogy', we demonstrate that plausibility bias impedes assessment of the clinical evidence. Sweeping statements about the scientific impossibility of homeopathy are themselves unscientific: scientific statements must be precise and testable. There is growing evidence that homeopathic preparations can exert biological effects; due consideration of such research would reduce the influence of prior beliefs on the assessment of systematic review evidence.

  3. The Lula Government’s Economic Policy: The Challenges of Transition and Alternatives for the Future

    Directory of Open Access Journals (Sweden)

    José Cezar Castanhar

    2004-05-01

    Full Text Available The adopting of a conservative and drastically orthodox economic, monetary and fiscal policy by the Brazilian government, headed by Luiz Inácio Lula da Silva, who has been in power for more than a year, has been justified by its promoters due to the country’s needs and delicate situation as well as to the absence of alternatives. In this sense, the author discusses and analyses the following questions in this article: Was the country at the edge of an abyss? Was there a possible alternative to the orthodox policy that was adopted? How, when and at what rate can the initial policy be changed? After underscoring the idea that the Lula Government is functioning, apparently, with a mixture of insecurity and ingenuous optimism, the author asserts the need to make an inexorable, but gradual, shift in the country’s current economic policy.

  4. Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010

    DEFF Research Database (Denmark)

    Adler, Sarah; Basketter, David; Creton, Stuart

    2011-01-01

    The 7th amendment to the EU Cosmetics Directive prohibits to put animal-tested cosmetics on the market in Europe after 2013. In that context, the European Commission invited stakeholder bodies (industry, non-governmental organisations, EU Member States, and the Commission's Scientific Committee...... methods would not be available in time. The selected experts were asked to analyse the status and prospects of alternative methods and to provide a scientifically sound estimate of the time necessary to achieve full replacement of animal testing. In summary, the experts confirmed that it will take...... on Consumer Safety) to identify scientific experts in five toxicological areas, i.e. toxicokinetics, repeated dose toxicity, carcinogenicity, skin sensitisation, and reproductive toxicity for which the Directive foresees that the 2013 deadline could be further extended in case alternative and validated...

  5. An Alternative to Kirk's Idea of the Idea and a Future for Physical Education

    Science.gov (United States)

    Smith, Wayne

    2011-01-01

    In his book "Physical Education Futures" (Routledge, London) David Kirk (2010) introduces the notion of the idea of the idea of physical education, which challenges all physical educators to think more deeply and broadly about physical education as a school subject. The notion of the idea of the idea enables a "big picture" conceptualisation of…

  6. Fueling the dragon: Alternative Chinese oil futures and their implications for the United States

    Science.gov (United States)

    Eberling, George G.

    This study examines how Chinese oil energy will likely shape future Sino-American relations under conditions of dependency and non-dependency. The study will list and describe three possible Chinese oil energy futures or scenarios (Competitive Dependency, Competitive Surplus and Cooperative Surplus) using Scenario Analysis to subsequently estimate their associated likelihoods using the PRINCE forecasting system and discuss and evaluate their strategic implications for the United States. Further, this study will determine the most likely oil energy future or scenario. Finally, the study will list and describe the most likely United States political, economic and/or military policy responses for each future or scenario. The study contributes to the literature on Chinese and United States energy security, foreign policy, political economy and political risk analysis by showing how China will most likely address its growing oil energy dependence and by determining what will be the most likely U.S. foreign policy consequences based on the most current literature available on energy security and foreign policy.

  7. Building Your Own Scenario: Marketing and Distributive Education, Sex Equity, and Alternative Futures.

    Science.gov (United States)

    Vetter, Louise; And Others

    This training manual, one in a seris of eight, has been developed to help state and local supervisors and teacher educators in marketing and distributive education to conduct a workshop on sex equity, as it relates to their future programs, for vocational education teachers and administrators in the marketing and distributive education service…

  8. Heterodox networks: An innovative and alternate approach to future wireless communications

    DEFF Research Database (Denmark)

    Lala, Purnima; Kumar, Ambuj

    2016-01-01

    It is imperative for the service providers to bring innovation in the network design to meet the exponential growth of mobile subscribers for multi-technology future wireless networks. As a matter of research, studies on providing services to moving subscriber groups aka ‘Place Time Capacity (PTC...

  9. Analytic Models of Plausible Gravitational Lens Potentials

    Energy Technology Data Exchange (ETDEWEB)

    Baltz, Edward A.; Marshall, Phil; Oguri, Masamune

    2007-05-04

    Gravitational lenses on galaxy scales are plausibly modeled as having ellipsoidal symmetry and a universal dark matter density profile, with a Sersic profile to describe the distribution of baryonic matter. Predicting all lensing effects requires knowledge of the total lens potential: in this work we give analytic forms for that of the above hybrid model. Emphasizing that complex lens potentials can be constructed from simpler components in linear combination, we provide a recipe for attaining elliptical symmetry in either projected mass or lens potential.We also provide analytic formulae for the lens potentials of Sersic profiles for integer and half-integer index. We then present formulae describing the gravitational lensing effects due to smoothly-truncated universal density profiles in cold dark matter model. For our isolated haloes the density profile falls off as radius to the minus fifth or seventh power beyond the tidal radius, functional forms that allow all orders of lens potential derivatives to be calculated analytically, while ensuring a non-divergent total mass. We show how the observables predicted by this profile differ from that of the original infinite-mass NFW profile. Expressions for the gravitational flexion are highlighted. We show how decreasing the tidal radius allows stripped haloes to be modeled, providing a framework for a fuller investigation of dark matter substructure in galaxies and clusters. Finally we remark on the need for finite mass halo profiles when doing cosmological ray-tracing simulations, and the need for readily-calculable higher order derivatives of the lens potential when studying catastrophes in strong lenses.

  10. Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.

    Science.gov (United States)

    Adler, Sarah; Basketter, David; Creton, Stuart; Pelkonen, Olavi; van Benthem, Jan; Zuang, Valérie; Andersen, Klaus Ejner; Angers-Loustau, Alexandre; Aptula, Aynur; Bal-Price, Anna; Benfenati, Emilio; Bernauer, Ulrike; Bessems, Jos; Bois, Frederic Y; Boobis, Alan; Brandon, Esther; Bremer, Susanne; Broschard, Thomas; Casati, Silvia; Coecke, Sandra; Corvi, Raffaella; Cronin, Mark; Daston, George; Dekant, Wolfgang; Felter, Susan; Grignard, Elise; Gundert-Remy, Ursula; Heinonen, Tuula; Kimber, Ian; Kleinjans, Jos; Komulainen, Hannu; Kreiling, Reinhard; Kreysa, Joachim; Leite, Sofia Batista; Loizou, George; Maxwell, Gavin; Mazzatorta, Paolo; Munn, Sharon; Pfuhler, Stefan; Phrakonkham, Pascal; Piersma, Aldert; Poth, Albrecht; Prieto, Pilar; Repetto, Guillermo; Rogiers, Vera; Schoeters, Greet; Schwarz, Michael; Serafimova, Rositsa; Tähti, Hanna; Testai, Emanuela; van Delft, Joost; van Loveren, Henk; Vinken, Mathieu; Worth, Andrew; Zaldivar, José-Manuel

    2011-05-01

    The 7th amendment to the EU Cosmetics Directive prohibits to put animal-tested cosmetics on the market in Europe after 2013. In that context, the European Commission invited stakeholder bodies (industry, non-governmental organisations, EU Member States, and the Commission's Scientific Committee on Consumer Safety) to identify scientific experts in five toxicological areas, i.e. toxicokinetics, repeated dose toxicity, carcinogenicity, skin sensitisation, and reproductive toxicity for which the Directive foresees that the 2013 deadline could be further extended in case alternative and validated methods would not be available in time. The selected experts were asked to analyse the status and prospects of alternative methods and to provide a scientifically sound estimate of the time necessary to achieve full replacement of animal testing. In summary, the experts confirmed that it will take at least another 7-9 years for the replacement of the current in vivo animal tests used for the safety assessment of cosmetic ingredients for skin sensitisation. However, the experts were also of the opinion that alternative methods may be able to give hazard information, i.e. to differentiate between sensitisers and non-sensitisers, ahead of 2017. This would, however, not provide the complete picture of what is a safe exposure because the relative potency of a sensitiser would not be known. For toxicokinetics, the timeframe was 5-7 years to develop the models still lacking to predict lung absorption and renal/biliary excretion, and even longer to integrate the methods to fully replace the animal toxicokinetic models. For the systemic toxicological endpoints of repeated dose toxicity, carcinogenicity and reproductive toxicity, the time horizon for full replacement could not be estimated.

  11. THE FUTURE OF EDUCATION INSPECTION IN ANDALUCIA: AN ALTERNATIVE FOR PROGRESS

    Directory of Open Access Journals (Sweden)

    José Orihuela Guerrero

    2014-06-01

    Advance of the Main Conclusions: The future proposal is related to the conception of the educational inspection as an educative changing agent and therefore, we are going to propose the placement of these professionals as a teaching character organ and as a dependent entity on the legislature, which should have a selection system based on a professional career and on a democratic system of internal organization.

  12. Roraima State: energy and alternatives to the future; Roraima: energia e alternativas para o futuro

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-10-01

    Report made by the Conselho Indigena de Roraima by and large with the Comissao Pro-Indio of Sao Paulo, addressed to the indigenous populations who lives near from the hydroelectric power plant on the state of Roraima, giving information about damns construction, energy electric uses, description of Hydroelectric and thermoelectric functioning, the energy program, electric energy landscape now and in the future, are presented. The work, was developed as support to meetings with the indigenous leaders. 7 figs.

  13. Encoding the target or the plausible preview word? The nature of the plausibility preview benefit in reading Chinese.

    Science.gov (United States)

    Yang, Jinmian; Li, Nan; Wang, Suiping; Slattery, Timothy J; Rayner, Keith

    2014-01-01

    Previous studies have shown that a plausible preview word can facilitate the processing of a target word as compared to an implausible preview word (a plausibility preview benefit effect) when reading Chinese (Yang, Wang, Tong, & Rayner, 2012; Yang, 2013). Regarding the nature of this effect, it is possible that readers processed the meaning of the plausible preview word and did not actually encode the target word (given that the parafoveal preview word lies close to the fovea). The current experiment examined this possibility with three conditions wherein readers received a preview of a target word that was either (1) identical to the target word (identical preview), (2) a plausible continuation of the pre-target text, but the post-target text in the sentence was incompatible with it (initially plausible preview), or (3) not a plausible continuation of the pre-target text, nor compatible with the post-target text (implausible preview). Gaze durations on target words were longer in the initially plausible condition than the identical condition. Overall, the results showed a typical preview benefit, but also implied that readers did not encode the initially plausible preview. Also, a plausibility preview benefit was replicated: gaze durations were longer with implausible previews than the initially plausible ones. Furthermore, late eye movement measures did not reveal differences between the initially plausible and the implausible preview conditions, which argues against the possibility of misreading the plausible preview word as the target word. In sum, these results suggest that a plausible preview word provides benefit in processing the target word as compared to an implausible preview word, and this benefit is only present in early but not late eye movement measures.

  14. Biologically plausible and evidence-based risk intervals in immunization safety research.

    Science.gov (United States)

    Rowhani-Rahbar, Ali; Klein, Nicola P; Dekker, Cornelia L; Edwards, Kathryn M; Marchant, Colin D; Vellozzi, Claudia; Fireman, Bruce; Sejvar, James J; Halsey, Neal A; Baxter, Roger

    2012-12-17

    In immunization safety research, individuals are considered at risk for the development of certain adverse events following immunization (AEFI) within a specific period of time referred to as the risk interval. These intervals should ideally be determined based on biologic plausibility considering features of the AEFI, presumed or known pathologic mechanism, and the vaccine. Misspecification of the length and timing of these intervals may result in introducing bias in epidemiologic and clinical studies of immunization safety. To date, little work has been done to formally assess and determine biologically plausible and evidence-based risk intervals in immunization safety research. In this report, we present a systematic process to define biologically plausible and evidence-based risk interval estimates for two specific AEFIs, febrile seizures and acute disseminated encephalomyelitis. In addition, we review methodologic issues related to the determination of risk intervals for consideration in future studies of immunization safety.

  15. Gas turbine for future alternative fuels; Gasturbine fuer die Brennstoffe der Zukunft

    Energy Technology Data Exchange (ETDEWEB)

    Koenemann, Detlef

    2011-07-01

    Power generation gas turbines use a wide range of fuels and are capable of rapid load changes. Because of this ability, they are an ideal compliment to future renewable energy supply. Against this backdrop MAN Diesel and Turbo SE decided several years ago, to develop a new series of gas turbines. The first is a machine in the 6-MW class that is now a product on the market and forms a technology platform for a range of further models now in development. (orig.)

  16. Alternative Argets Within the Endocannabinoid System for Future Treatment of Gastrointestinal Diseases

    Directory of Open Access Journals (Sweden)

    Rudolf Schicho

    2011-01-01

    Full Text Available Many beneficial effects of herbal and synthetic cannabinoids on gut motility and inflammation have been demonstrated, suggesting a vast potential for these compounds in the treatment of gastrointestinal disorders. These effects are based on the so-called ‘endocannabinoid system’ (ECS, a cooperating network of molecules that regulate the metabolism of the body’s own and of exogenously administered cannabinoids. The ECS in the gastrointestinal tract quickly responds to homeostatic disturbances by de novo synthesis of its components to maintain homeostasis, thereby offering many potential targets for pharmacological intervention. Of major therapeutic interest are nonpsychoactive cannabinoids or compounds that do not directly target cannabinoid receptors but still possess cannabinoid-like properties. Drugs that inhibit endocannabinoid degradation and raise the level of endocannabinoids are becoming increasingly promising alternative therapeutic tools to manipulate the ECS.

  17. Towards nanomedicines of the future: Remote magneto-mechanical actuation of nanomedicines by alternating magnetic fields☆

    Science.gov (United States)

    Golovin, Yuri I.; Gribanovsky, Sergey L.; Golovin, Dmitry Y.; Klyachko, Natalia L.; Majouga, Alexander G.; Master, Alyssa M.; Sokolsky, Marina; Kabanov, Alexander V.

    2015-01-01

    The paper describes the concept of magneto-mechanical actuation of single-domain magnetic nanoparticles (MNPs) in super-low and low frequency alternating magnetic fields (AMFs) and its possible use for remote control of nanomedicines and drug delivery systems. The applications of this approach for remote actuation of drug release as well as effects on biomacromolecules, biomembranes, subcellular structures and cells are discussed in comparison to conventional strategies employing magnetic hyperthermia in a radio frequency (RF) AMF. Several quantitative models describing interaction of functionalized MNPs with single macromolecules, lipid membranes, and proteins (e.g. cell membrane receptors, ion channels) are presented. The optimal characteristics of the MNPs and an AMF for effective magneto-mechanical actuation of single molecule responses in biological and bio-inspired systems are discussed. Altogether, the described studies and phenomena offer opportunities for the development of novel therapeutics both alone and in combination with magnetic hyperthermia. PMID:26407671

  18. An integrated approach to shaping the future of alternative energy in Canada

    Energy Technology Data Exchange (ETDEWEB)

    James, D. [EnergyINet Inc., Calgary, AB (Canada)

    2005-07-01

    EnergyINet Inc. is an energy innovation network that is part of the Alberta Energy Research Institute and the Alberta Government. Its mandate is to link industry, government and academia to facilitate innovation and research in energy. The organization's strategic goals are to maintain a competitive energy supply, take advantage of the shift in energy systems and put Canada at the forefront of integration between energy systems. EnergyINet's value-added approach is to develop an integrated strategy that results in better industry participation and technology transfer while reducing the risk of costly investment in technology. Current innovation programs focus on oil sands upgrading; clean coal technology with carbon sequestration; enhanced recovery; alternate and renewable energy; water management and carbon dioxide management. The organization's cross-cutting initiatives include capacity building; global intelligence; strategic communications and technology commercialization. EnergyINet's objective is develop energy resources that reduce dependence of fossil fuels while better utilizing existing energy sources to reduce greenhouse gas emissions. The strategy is to catalyze research and development to achieve an effective and environmentally suitable mix or alternate and renewable energy technologies. This presentation included graphs depicting Canadian energy sector growth from 1985 to the present; conversion of the Canadian economy to impure hydrogen for heating and transportation; an impure hydrogen value hierarchy; impure hydrogen implementation; and, hydrogen option examples such as wind electric power, hydrogen by electrolysis, electric power generation by hydrocarbon gasification, and distributed power generation with combined heat and power. It was noted that regulations and infrastructure are the key challenges facing hydrogen technology options in terms of production, transportation and applications. The action plan is to expand the

  19. Moving to a low-carbon future: perspectives on nuclear and alternative power sources.

    Science.gov (United States)

    Morgan, M Granger

    2007-11-01

    This paper summarizes key findings from climate science to make the case that the United States (and ultimately the world) will need to dramatically reduce carbon dioxide emissions from the energy system over the next few decades. While transportation energy is an important consideration, the focus of this paper is on electric power. Today, the United States generates just over half of its electric power from coal. The average size-weighted age of the fleet of U.S. coal plants is 35 y, and many will have to be replaced in the next few years. If that capacity were to be replaced with new conventional coal plants, it would commit the nation (and the world) to many more decades of high carbon-dioxide emissions, or it would make the cost of meeting a future carbon-dioxide emission constraint much higher than it needs to be. A range of low- and no-carbon energy technologies offers great potential to create a portfolio of options that can dramatically reduce emissions. A few of the advantages and disadvantages of these technologies are discussed. Policy and regulatory advances that will be needed to move the energy system to a low-carbon future are identified.

  20. Moving to a low-carbon future: Perspectives on nuclear and alternative power sources

    Energy Technology Data Exchange (ETDEWEB)

    Morgan, M.G. [Carnegie Mellon University, Pittsburgh, PA (United States)

    2007-11-15

    This paper summarizes key findings from climate science to make the case that the United States (and ultimately the world) will need to dramatically reduce carbon dioxide emissions from the energy system over the next few decades. While transportation energy is an important consideration, the focus of this paper is on electric power. Today, the United States generates just over half of its electric power from coal. The average size-weighted age of the fleet of U.S. coal plants is 35 y, and many will have to be replaced in the next few years. If that capacity were to be replaced with new conventional coal plants, it would commit the nation (and the world) to many more decades of high carbon-dioxide emissions, or it would make the cost of meeting a future carbon-dioxide emission constraint much higher than it needs to be. A range of low- and no-carbon energy technologies offers great potential to create a portfolio of options that can dramatically reduce emissions. A few of the advantages and disadvantages of these technologies are discussed. Policy and regulatory advances that will be needed to move the energy system to a low-carbon future are identified.

  1. The role of augmentative and alternative communication for children with autism: current status and future trends

    Directory of Open Access Journals (Sweden)

    Iacono T

    2016-09-01

    Full Text Available Teresa Iacono,1 David Trembath,2 Shane Erickson3 1Living with Disability Research Centre, La Trobe University, Bendigo, VIC, Australia; 2Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia; 3Living with Disability Research Centre, La Trobe University, Melbourne, VIC, Australia Background: Augmentative and alternative communication (AAC interventions are used for children with autism, often as stand-alone communication interventions for those who are minimally verbal. Our aim was to synthesize the evidence for AAC interventions for children (up to 21 years, and then consider the role of AAC within established, comprehensive, evidence-based autism interventions targeting learning across multiple developmental domains.Design: We completed a systematic search of three databases (OVID Medline, PsycINFO, ERIC as well as forward citation and hand searches to identify systematic reviews of AAC intervention efficacy research including children with autism, published between 2000 and March 2016 in peer-reviewed journals. Data pertaining to the quality indicators of included studies, effect sizes for intervention outcomes, and evidence for effectiveness were extracted for descriptive analysis.Results: The search yielded 17 systematic reviews. Most provided indicators of research quality for included studies, of which only relatively few provided conclusive results. Communication targets tended to be focused on teaching children to make requests. Still, effect size measures for included studies indicated that AAC was effective to highly effective.Conclusion: There is growing evidence for the potential benefits of AAC for children with autism, but there is a need for more well-designed studies and broader, targeted outcomes. Furthermore, a lack of evidence for the role of AAC within comprehensive intervention programs may account for a tendency by autism researchers and practitioners to neglect this intervention. Attempts to

  2. Consumptive Water Use from Electricity Generation in the Southwest under Alternative Climate, Technology, and Policy Futures.

    Science.gov (United States)

    Talati, Shuchi; Zhai, Haibo; Kyle, G Page; Morgan, M Granger; Patel, Pralit; Liu, Lu

    2016-11-15

    This research assesses climate, technological, and policy impacts on consumptive water use from electricity generation in the Southwest over a planning horizon of nearly a century. We employed an integrated modeling framework taking into account feedbacks between climate change, air temperature and humidity, and consequent power plant water requirements. These direct impacts of climate change on water consumption by 2095 differ with technology improvements, cooling systems, and policy constraints, ranging from a 3-7% increase over scenarios that do not incorporate ambient air impacts. Upon additional factors being changed that alter electricity generation, water consumption increases by up to 8% over the reference scenario by 2095. With high penetration of wet recirculating cooling, consumptive water required for low-carbon electricity generation via fossil fuels will likely exacerbate regional water pressure as droughts become more common and population increases. Adaptation strategies to lower water use include the use of advanced cooling technologies and greater dependence on solar and wind. Water consumption may be reduced by 50% in 2095 from the reference, requiring an increase in dry cooling shares to 35-40%. Alternatively, the same reduction could be achieved through photovoltaic and wind power generation constituting 60% of the grid, consistent with an increase of over 250% in technology learning rates.

  3. Consumptive Water Use from Electricity Generation in the Southwest under Alternative Climate, Technology, and Policy Futures

    Energy Technology Data Exchange (ETDEWEB)

    Talati, Shuchi; Zhai, Haibo; Kyle, G. Page; Morgan, M. Granger; Patel, Pralit; Liu, Lu

    2016-10-21

    This research assesses climate, technological, and policy impacts on consumptive water use from electricity generation in the Southwest over a planning horizon of nearly a century. We employed an integrated modeling framework taking into account feedbacks between climate change, air temperature and humidity, and consequent power plant water requirements. These direct impacts of climate change on water consumption by 2095 differ with technology improvements, cooling systems, and policy constraints, ranging from a 3–7% increase over scenarios that do not incorporate ambient air impacts. Upon additional factors being changed that alter electricity generation, water consumption increases by up to 8% over the reference scenario by 2095. With high penetration of wet recirculating cooling, consumptive water required for low-carbon electricity generation via fossil fuels will likely exacerbate regional water pressure as droughts become more common and population increases. Adaptation strategies to lower water use include the use of advanced cooling technologies and greater dependence on solar and wind. Water consumption may be reduced by 50% in 2095 from the reference, requiring an increase in dry cooling shares to 35–40%. Alternatively, the same reduction could be achieved through photovoltaic and wind power generation constituting 60% of the grid, consistent with an increase of over 250% in technology learning rates.

  4. Regulatory Forum commentary: alternative mouse models for future cancer risk assessment.

    Science.gov (United States)

    Morton, Daniel; Sistare, Frank D; Nambiar, Prashant R; Turner, Oliver C; Radi, Zaher; Bower, Nancy

    2014-07-01

    International regulatory and pharmaceutical industry scientists are discussing revision of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) S1 guidance on rodent carcinogenicity assessment of small molecule pharmaceuticals. A weight-of-evidence approach is proposed to determine the need for rodent carcinogenicity studies. For compounds with high human cancer risk, the product may be labeled appropriately without conducting rodent carcinogenicity studies. For compounds with minimal cancer risk, only a 6-month transgenic mouse study (rasH2 mouse or p53+/- mouse) or a 2-year mouse study would be needed. If rodent carcinogenicity testing may add significant value to cancer risk assessment, a 2-year rat study and either a 6-month transgenic mouse or a 2-year mouse study is appropriate. In many cases, therefore, one rodent carcinogenicity study could be sufficient. The rasH2 model predicts neoplastic findings relevant to human cancer risk assessment as well as 2-year rodent models, produces fewer irrelevant neoplastic outcomes, and often will be preferable to a 2-year rodent study. Before revising ICH S1 guidance, a prospective evaluation will be conducted to test the proposed weight-of-evidence approach. This evaluation offers an opportunity for a secondary analysis comparing the value of alternative mouse models and 2-year rodent studies in the proposed ICH S1 weight-of-evidence approach for human cancer risk assessment.

  5. Plausibility Judgments in Conceptual Change and Epistemic Cognition

    Science.gov (United States)

    Lombardi, Doug; Nussbaum, E. Michael; Sinatra, Gale M.

    2016-01-01

    Plausibility judgments rarely have been addressed empirically in conceptual change research. Recent research, however, suggests that these judgments may be pivotal to conceptual change about certain topics where a gap exists between what scientists and laypersons find plausible. Based on a philosophical and empirical foundation, this article…

  6. Source Effects and Plausibility Judgments When Reading about Climate Change

    Science.gov (United States)

    Lombardi, Doug; Seyranian, Viviane; Sinatra, Gale M.

    2014-01-01

    Gaps between what scientists and laypeople find plausible may act as a barrier to learning complex and/or controversial socioscientific concepts. For example, individuals may consider scientific explanations that human activities are causing current climate change as implausible. This plausibility judgment may be due-in part-to individuals'…

  7. A plausible explanation for male dominance in typhoid ileal perforation

    Directory of Open Access Journals (Sweden)

    Khan M

    2012-11-01

    Full Text Available Mohammad KhanDepartment of Microbiology, College of Medicine, Chichiri, Blantyre, MalawiAbstract: The phenomenon of consistent male dominance in typhoid ileal perforation (TIP is not well understood. It cannot be explained on the basis of microbial virulence, Peyer's patch anatomy, ileal wall thickness, gastric acidity, host genetic factors, or sex-linked bias in hospital attendance. The cytokine response to an intestinal infection in males is predominantly proinflammatory as compared with that in females, presumably due to differences in the sex hormonal milieu. Sex hormone receptors have been detected on lymphocytes and macrophages, including on Peyer's patches, inflammation of which (probably similar to the Shwartzman reaction/Koch phenomenon is the forerunner of TIP, and is not excluded from the regulatory effects of sex hormones. Hormonal control of host-pathogen interaction may override genetic control. Environmental exposure to Salmonella typhi may be more frequent in males, presumably due to sex-linked differences in hygiene practices and dining-out behavior. A plausible explanation of male dominance in TIP could include sex-linked differences in the degree of natural exposure of Peyer's patches to S. typhi. An alternative explanation may include sexual dimorphism in host inflammatory response patterns in Peyer's patches that have been induced by S. typhi. Both hypotheses are testable.Keywords: explanation, dominance, male, perforation, ileum, typhoid

  8. A plausible explanation for male dominance in typhoid ileal perforation.

    Science.gov (United States)

    Khan, Mohammad

    2012-01-01

    The phenomenon of consistent male dominance in typhoid ileal perforation (TIP) is not well understood. It cannot be explained on the basis of microbial virulence, Peyer's patch anatomy, ileal wall thickness, gastric acidity, host genetic factors, or sex-linked bias in hospital attendance. The cytokine response to an intestinal infection in males is predominantly proinflammatory as compared with that in females, presumably due to differences in the sex hormonal milieu. Sex hormone receptors have been detected on lymphocytes and macrophages, including on Peyer's patches, inflammation of which (probably similar to the Shwartzman reaction/Koch phenomenon) is the forerunner of TIP, and is not excluded from the regulatory effects of sex hormones. Hormonal control of host-pathogen interaction may override genetic control. Environmental exposure to Salmonella typhi may be more frequent in males, presumably due to sex-linked differences in hygiene practices and dining-out behavior. A plausible explanation of male dominance in TIP could include sex-linked differences in the degree of natural exposure of Peyer's patches to S. typhi. An alternative explanation may include sexual dimorphism in host inflammatory response patterns in Peyer's patches that have been induced by S. typhi. Both hypotheses are testable.

  9. High prevalence but limited evidence in complementary and alternative medicine: guidelines for future research.

    Science.gov (United States)

    Fischer, Felix H; Lewith, George; Witt, Claudia M; Linde, Klaus; von Ammon, Klaus; Cardini, Francesco; Falkenberg, Torkel; Fønnebø, Vinjar; Johannessen, Helle; Reiter, Bettina; Uehleke, Bernhard; Weidenhammer, Wolfgang; Brinkhaus, Benno

    2014-02-06

    The use of complementary and alternative Medicine (CAM) has increased over the past two decades in Europe. Nonetheless, research investigating the evidence to support its use remains limited. The CAMbrella project funded by the European Commission aimed to develop a strategic research agenda starting by systematically evaluating the state of CAM in the EU. CAMbrella involved 9 work packages covering issues such as the definition of CAM; its legal status, provision and use in the EU; and a synthesis of international research perspectives. Based on the work package reports, we developed a strategic and methodologically robust research roadmap based on expert workshops, a systematic Delphi-based process and a final consensus conference. The CAMbrella project suggests six core areas for research to examine the potential contribution of CAM to the health care challenges faced by the EU. These areas include evaluating the prevalence of CAM use in Europe; the EU cititzens' needs and attitudes regarding CAM; the safety of CAM; the comparative effectiveness of CAM; the effects of meaning and context on CAM outcomes; and different models for integrating CAM into existing health care systems. CAM research should use methods generally accepted in the evaluation of health services, including comparative effectiveness studies and mixed-methods designs. A research strategy is urgently needed, ideally led by a European CAM coordinating research office dedicated to fostering systematic communication between EU governments, the public, charitable and industry funders, researchers and other stakeholders. A European Centre for CAM should also be established to monitor and further a coordinated research strategy with sufficient funds to commission and promote high quality, independent research focusing on the public's health needs and pan-European collaboration. There is a disparity between highly prevalent use of CAM in Europe and solid knowledge about it. A strategic approach on CAM

  10. Utilization of plant-based natural coagulants as future alternatives towards sustainable water clarification.

    Science.gov (United States)

    Choy, Sook Yan; Prasad, Krishna Murthy Nagendra; Wu, Ta Yeong; Raghunandan, Mavinakere Eshwaraiah; Ramanan, Ramakrishnan Nagasundara

    2014-11-01

    Rapid industrial developments coupled with surging population growth have complicated issues dealing with water scarcity as the quest for clean and sanitized water intensifies globally. Existing fresh water supplies could be contaminated with organic, inorganic and biological matters that have potential harm to the society. Turbidity in general is a measure of water cloudiness induced by such colloidal and suspended matters and is also one of the major criteria in raw water monitoring to meet the stipulated water quality guidelines. Turbidity reduction is often accomplished using chemical coagulants such as alum. The use of alum is widely associated with potential development of health issues and generation of voluminous sludge. Natural coagulants that are available in abundance can certainly be considered in addressing the drawbacks associated with the use of chemical coagulants. Twenty one types of plant-based natural coagulants categorized as fruit waste and others are identified and presented collectively with their research summary in this review. The barriers and prospects of commercialization of natural coagulants in near future are also discussed.

  11. THE PRESENT AND FUTURE OF CLINICAL AND HEALTH PSYCHOLOGY IN SPAIN: AN ALTERNATIVE VIEW

    Directory of Open Access Journals (Sweden)

    José Antonio Carrobles

    2015-01-01

    Full Text Available In our country, there are currently two types of psychologist qualified to practise psychology in the health field: the Specialist Psychologist in Clinical Psychology (PEPC and the General Health Psychologist (PGS. These qualifications are legally regulated and their accreditation is obtained through two different programs of postgraduate training: the Residential Internship Program (PIR in the case of the PEPC; and the Master of General Health Psychology (MPGS in the case of the PGS. These programs are of different lengths (4 years for the PIR and 2 years for the MPGS and they are accessed after completion of the corresponding degree in Psychology. However, the objectives and the skills to be attained, as well as the content of the training programs, are actually very similar, in spite of the different linguistic denominations used to describe them. On the basis of the existing differences in the terminology and the duration of the programs, some Spanish associations (ANPIR, COP, AEPCP and AEN defend the position that there should be established between the two qualifications, in addition to a hierarchical structure, a clear boundary with respect to the functions that the two types of psychologist can perform (clinical and specialised versus health and general functions and of the sectors or contexts in which they can practise (public versus private. In our article, we refute these positions and the reasons on which they are based and we argue extensively in favour of an alternative proposal more in tune with the reality of the facts and with the European context professional accreditation in clinical psychology, in the sense of accepting the existence of the two independent qualifications of clinical psychologists (the PEPC and the PGS, with direct access to both from the degree in Psychology, and with equivalent competencies and professional functions, although with some limitations in the case of the PGS, mainly with respect to the

  12. Ethical guidelines, animal profile, various animal models used in periodontal research with alternatives and future perspectives

    Science.gov (United States)

    Pasupuleti, Mohan Kumar; Molahally, Subramanya Shetty; Salwaji, Supraja

    2016-01-01

    Laboratory animal models serve as a facilitator to investigate the etiopathogenesis of periodontal disease, are used to know the efficacy of reconstructive and regenerative procedures, and are also helpful in evaluation of newer therapeutic techniques including laser and implant therapies prior to application in the human beings. The aim of this review is to know the different animal models used in various specialties of dental research and to know the ethical guidelines prior to the usage of experimental models with main emphasis on how to refine, replace, and reduce the number of animal models usage in the laboratory. An online search for experimental animal models used in dental research was performed using MEDLINE/PubMed database. Publications from 2009 to May 2013 in the specialty of periodontics were included in writing this review. A total of 652 references were published in PubMed/MEDLINE databases based on the search terms used. Out of 245 studies, 241 were related to the periodontal research published in English from 2009 to 2013. Relevant papers were chosen according to the inclusion and exclusion criteria. After extensive electronic and hand search on animal models, it has been observed that various animal models were used in dental research. Search on animal models used for dental research purpose revealed that various animals such as rats, mice, guinea pigs, rabbit, beagle dogs, goats, and nonhuman primates were extensively used. However, with the new advancement of ex vivo animal models, it has become easy to investigate disease pathogenesis and to test the efficacy of newer therapeutic modalities with the reduced usage of animal models. This review summarized the large amount of literature on animal models used in periodontal research with main emphasis on ethical guidelines and on reducing the animal model usage in future perspective. PMID:28298815

  13. Ethical guidelines, animal profile, various animal models used in periodontal research with alternatives and future perspectives

    Directory of Open Access Journals (Sweden)

    Mohan Kumar Pasupuleti

    2016-01-01

    Full Text Available Laboratory animal models serve as a facilitator to investigate the etiopathogenesis of periodontal disease, are used to know the efficacy of reconstructive and regenerative procedures, and are also helpful in evaluation of newer therapeutic techniques including laser and implant therapies prior to application in the human beings. The aim of this review is to know the different animal models used in various specialties of dental research and to know the ethical guidelines prior to the usage of experimental models with main emphasis on how to refine, replace, and reduce the number of animal models usage in the laboratory. An online search for experimental animal models used in dental research was performed using MEDLINE/PubMed database. Publications from 2009 to May 2013 in the specialty of periodontics were included in writing this review. A total of 652 references were published in PubMed/MEDLINE databases based on the search terms used. Out of 245 studies, 241 were related to the periodontal research published in English from 2009 to 2013. Relevant papers were chosen according to the inclusion and exclusion criteria. After extensive electronic and hand search on animal models, it has been observed that various animal models were used in dental research. Search on animal models used for dental research purpose revealed that various animals such as rats, mice, guinea pigs, rabbit, beagle dogs, goats, and nonhuman primates were extensively used. However, with the new advancement of ex vivo animal models, it has become easy to investigate disease pathogenesis and to test the efficacy of newer therapeutic modalities with the reduced usage of animal models. This review summarized the large amount of literature on animal models used in periodontal research with main emphasis on ethical guidelines and on reducing the animal model usage in future perspective.

  14. Futurism.

    Science.gov (United States)

    Foy, Jane Loring

    The objectives of this research report are to gain insight into the main problems of the future and to ascertain the attitudes that the general population has toward the treatment of these problems. In the first section of this report the future is explored socially, psychologically, and environmentally. The second section describes the techniques…

  15. Tools and methods for evaluating and refining alternative futures for coastal ecosystem management—the Puget Sound Ecosystem Portfolio Model

    Science.gov (United States)

    Byrd, Kristin B.; Kreitler, Jason R.; Labiosa, William B.

    2011-01-01

    The U.S. Geological Survey Puget Sound Ecosystem Portfolio Model (PSEPM) is a decision-support tool that uses scenarios to evaluate where, when, and to what extent future population growth, urban growth, and shoreline development may threaten the Puget Sound nearshore environment. This tool was designed to be used iteratively in a workshop setting in which experts, stakeholders, and decisionmakers discuss consequences to the Puget Sound nearshore within an alternative-futures framework. The PSEPM presents three possible futures of the nearshore by analyzing three growth scenarios developed out to 2060: Status Quo—continuation of current trends; Managed Growth—adoption of an aggressive set of land-use management policies; and Unconstrained Growth—relaxation of land-use restrictions. The PSEPM focuses on nearshore environments associated with barrier and bluff-backed beaches—the most dominant shoreforms in Puget Sound—which represent 50 percent of Puget Sound shorelines by length. This report provides detailed methodologies for development of three submodels within the PSEPM—the Shellfish Pollution Model, the Beach Armoring Index, and the Recreation Visits Model. Results from the PSEPM identify where and when future changes to nearshore ecosystems and ecosystem services will likely occur within the three growth scenarios. Model outputs include maps that highlight shoreline sections where nearshore resources may be at greater risk from upland land-use changes. The background discussed in this report serves to document and supplement model results displayed on the PSEPM Web site located at http://geography.wr.usgs.gov/pugetSound/.

  16. Comparison of methods for controlling dental caries in the classical medicine and alternative medical practices and future prospects

    Directory of Open Access Journals (Sweden)

    Rabbani Khorasgani Mohammad

    2015-07-01

    Full Text Available Dental caries is a multi-factorial disease and the most common human infection that annually are spent millions dollars to control and treat it. Several methods have been proposed so far to control it. The most important control methods it is now include : dental hygiene, proper nutrition , fluoride therapy , the use of non- cariogenic sweeteners . Also, the use of probiotics , nanomaterials , bacteriophages , antimicrobial peptides and anti- caries vaccines can be considered as new perspective of human in the dental caries control field. In addition, the use of complementary and alternative therapies , especially herbal drug therapy recently has been considered . Demonstrating the efficacy of complementary medicine against dental caries and its use in combination with conventional medicine or trial of new methods for decline of dental caries in the future would be hopeful.

  17. Plausible values: how to deal with their limitations.

    Science.gov (United States)

    Monseur, Christian; Adams, Raymond

    2009-01-01

    Rasch modeling and plausible values methodology were used to scale and report the results of the Organization for Economic Cooperation and Development's Programme for International Student Achievement (PISA). This article will describe the scaling approach adopted in PISA. In particular it will focus on the use of plausible values, a multiple imputation approach that is now commonly used in large-scale assessment. As with all imputation models the plausible values must be generated using models that are consistent with those used in subsequent data analysis. In the case of PISA the plausible value generation assumes a flat linear regression with all students' background variables collected through the international student questionnaire included as regressors. Further, like most linear models, homoscedasticity and normality of the conditional variance are assumed. This article will explore some of the implications of this approach. First, we will discuss the conditions under which the secondary analyses on variables not included in the model for generating the plausible values might be biased. Secondly, as plausible values were not drawn from a multi-level model, the article will explore the adequacy of the PISA procedures for estimating variance components when the data have a hierarchical structure.

  18. Antioxidant agents: a future alternative approach in the prevention and treatment of radiation-induced oral mucositis?

    Science.gov (United States)

    de Freitas Cuba, Letícia; Salum, Fernanda Gonçalves; Cherubini, Karen; de Figueiredo, Maria Antonia Zancanaro

    2015-01-01

    Radiotherapy is a therapeutic modality frequently employed for patients with head and neck cancer (HNC). It destroys tumor cells, but it is not selective, also affecting healthy tissues and producing adverse effects. One that stands out is oral mucositis because of the morbidity that it is capable of causing. This lesion is characterized by the presence of erythema, ulcerations, pain, opportunistic infections, and weight loss. These side effects can lead to serious situations that require the interruption of the antineoplastic treatment and can result in hospitalization and even death. The complex mechanisms linked to the pathogenesis of oral mucositis were recently established, and since then, the control of oxidative stress (OS) has been tied to the prevention and management of this disease. The authors have carried out a review of the literature about the use of antioxidant agents in the prevention and treatment of radiation-induced oral mucositis, using the PubMed database. This review has shown that the research on use of antioxidants (AOX) has proved insufficient to justify suggesting the products in treatment protocols. Results are promising, however, and AOX may represent a future alternative in the prevention and treatment of oral mucositis.

  19. Some Remarks on the Model Theory of Epistemic Plausibility Models

    CERN Document Server

    Demey, Lorenz

    2010-01-01

    Classical logics of knowledge and belief are usually interpreted on Kripke models, for which a mathematically well-developed model theory is available. However, such models are inadequate to capture dynamic phenomena. Therefore, epistemic plausibility models have been introduced. Because these are much richer structures than Kripke models, they do not straightforwardly inherit the model-theoretical results of modal logic. Therefore, while epistemic plausibility structures are well-suited for modeling purposes, an extensive investigation of their model theory has been lacking so far. The aim of the present paper is to fill exactly this gap, by initiating a systematic exploration of the model theory of epistemic plausibility models. Like in 'ordinary' modal logic, the focus will be on the notion of bisimulation. We define various notions of bisimulations (parametrized by a language L) and show that L-bisimilarity implies L-equivalence. We prove a Hennesy-Milner type result, and also two undefinability results. ...

  20. The Plausibility of a String Quartet Performance in Virtual Reality.

    Science.gov (United States)

    Bergstrom, Ilias; Azevedo, Sergio; Papiotis, Panos; Saldanha, Nuno; Slater, Mel

    2017-04-01

    We describe an experiment that explores the contribution of auditory and other features to the illusion of plausibility in a virtual environment that depicts the performance of a string quartet. 'Plausibility' refers to the component of presence that is the illusion that the perceived events in the virtual environment are really happening. The features studied were: Gaze (the musicians ignored the participant, the musicians sometimes looked towards and followed the participant's movements), Sound Spatialization (Mono, Stereo, Spatial), Auralization (no sound reflections, reflections corresponding to a room larger than the one perceived, reflections that exactly matched the virtual room), and Environment (no sound from outside of the room, birdsong and wind corresponding to the outside scene). We adopted the methodology based on color matching theory, where 20 participants were first able to assess their feeling of plausibility in the environment with each of the four features at their highest setting. Then five times participants started from a low setting on all features and were able to make transitions from one system configuration to another until they matched their original feeling of plausibility. From these transitions a Markov transition matrix was constructed, and also probabilities of a match conditional on feature configuration. The results show that Environment and Gaze were individually the most important factors influencing the level of plausibility. The highest probability transitions were to improve Environment and Gaze, and then Auralization and Spatialization. We present this work as both a contribution to the methodology of assessing presence without questionnaires, and showing how various aspects of a musical performance can influence plausibility.

  1. Families of Plausible Solutions to the Puzzle of Boyajian’s Star

    Science.gov (United States)

    Wright, Jason T.; Sigurd̵sson, Steinn

    2016-09-01

    Good explanations for the unusual light curve of Boyajian's Star have been hard to find. Recent results by Montet & Simon lend strength and plausibility to the conclusion of Schaefer that in addition to short-term dimmings, the star also experiences large, secular decreases in brightness on decadal timescales. This, combined with a lack of long-wavelength excess in the star's spectral energy distribution, strongly constrains scenarios involving circumstellar material, including hypotheses invoking a spherical cloud of artifacts. We show that the timings of the deepest dimmings appear consistent with being randomly distributed, and that the star's reddening and narrow sodium absorption is consistent with the total, long-term dimming observed. Following Montet & Simon's encouragement to generate alternative hypotheses, we attempt to circumscribe the space of possible explanations with a range of plausibilities, including: a cloud in the outer solar system, structure in the interstellar medium (ISM), natural and artificial material orbiting Boyajian's Star, an intervening object with a large disk, and variations in Boyajian's Star itself. We find the ISM and intervening disk models more plausible than the other natural models.

  2. ‘One of the Challenges that Can Plausibly Be Raised Against Them’?

    DEFF Research Database (Denmark)

    Holtermann, Jakob v. H.

    2017-01-01

    International criminal tribunals (ICTs) are epistemic engines in the sense that they find (or claim to find) factual truths about such past events that qualify as genocide, crimes against humanity and war crimes. The value of this kind of knowledge would seem to be beyond dispute. Yet, in general...... in law is intimately connected to ordinary truth. Truth-finding capacity therefore does belong in legitimacy debates as a challenge that can plausibly be raised against them. This, in turn makes it relevant, in future research, to map, analyse and interrelate the various critiques that have been launched...

  3. Renewable (alternative) energies. Real future of the power supply including nuclear power. 2. enl. upd. ed.; Erneuerbare (alternative) Energien. Reale Zukunft der Energieversorgung, einschliesslich Kernenergie

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, Karl-Heinz [Fachhochschule Suedwestfalen - Hochschule fuer Technik und Wirtschaft, Soest (Germany); Institut fuer Technologie- und Wissenstransfer an der Hochschulabteilung Soest (Germany); Giber, Janos [TU Budapest (Hungary). Institut fuer Atomphysik

    2010-07-01

    The scarceness of fossil fuels as well as the greenhouse effect affect the economic, technological, social and political development world-wide. The use of renewable energies for the future power supply seems to be a solution. Under this aspect, the book under consideration gives a compact general view of the potentials and availability of the fossil fuels and the renewable energies. Scenarios are discussed in detail under economic and ecological criteria. The limits of the individual sources of energy (fossil, renewable, nuclear sources of energy) are discussed based on comprehensible, reliable sources. By means of simple example calculations and an extensive table statements can be understood.

  4. Representations of physical plausibility revealed by event-related potentials.

    Science.gov (United States)

    Roser, Matthew E; Fugelsang, Jonathan A; Handy, Todd C; Dunbar, Kevin N; Gazzaniga, Michael S

    2009-08-05

    Maintaining an accurate mental representation of the current environment is crucial to detecting change in that environment and ensuring behavioral coherence. Past experience with interactions between objects, such as collisions, has been shown to influence the perception of object interactions. To assess whether mental representations of object interactions derived from experience influence the maintenance of a mental model of the current stimulus environment, we presented physically plausible and implausible collision events while recording brain electrical activity. The parietal P300 response to 'oddball' events was found to be modulated by the physical plausibility of the stimuli, suggesting that past experience of object interactions can influence working memory processes involved in monitoring ongoing changes to the environment.

  5. Probabilistic reasoning in intelligent systems networks of plausible inference

    CERN Document Server

    Pearl, Judea

    1988-01-01

    Probabilistic Reasoning in Intelligent Systems is a complete and accessible account of the theoretical foundations and computational methods that underlie plausible reasoning under uncertainty. The author provides a coherent explication of probability as a language for reasoning with partial belief and offers a unifying perspective on other AI approaches to uncertainty, such as the Dempster-Shafer formalism, truth maintenance systems, and nonmonotonic logic. The author distinguishes syntactic and semantic approaches to uncertainty--and offers techniques, based on belief networks, that provid

  6. Complex Learning in Bio-plausible Memristive Networks

    OpenAIRE

    Deng, Lei; Li, Guoqi; Deng, Ning; Dong WANG; Zhang, Ziyang; He, Wei; Li, Huanglong; Pei, Jing; Shi, Luping

    2015-01-01

    The emerging memristor-based neuromorphic engineering promises an efficient computing paradigm. However, the lack of both internal dynamics in the previous feedforward memristive networks and efficient learning algorithms in recurrent networks, fundamentally limits the learning ability of existing systems. In this work, we propose a framework to support complex learning functions by introducing dedicated learning algorithms to a bio-plausible recurrent memristive network with internal dynamic...

  7. Implications of alternative assumptions regarding future air pollution control in scenarios similar to the Representative Concentration Pathways

    NARCIS (Netherlands)

    Chuwah, C.; van Noije, T.; van Vuuren, D.P.; Hazeleger, W.; Strunk, A.; Deetman, S.; Beltran, A.M.; van Vliet, J.

    2013-01-01

    The uncertain, future development of emissions of short-lived trace gases and aerosols forms a key factor for future air quality and climate forcing. The Representative Concentration Pathways (RCPs) only explore part of this range as they all assume that worldwide ambitious air pollution control pol

  8. Implications of alternative assumptions regarding future air pollution control in scenarios similar to the Representative Concentration Pathways

    NARCIS (Netherlands)

    Chuwah, C.D.; Noije, van T.; Vuuren, van D.P.; Hazeleger, W.; Strunk, A.; Deetman, S.; Beltran, A.M.; Vliet, van de J.

    2013-01-01

    The uncertain, future development of emissions of short-lived trace gases and aerosols forms a key factor for future air quality and climate forcing. The Representative Concentration Pathways (RCPs) only explore part of this range as they all assume that worldwide ambitious air pollution control

  9. Implications of alternative assumptions regarding future air pollution control in scenarios similar to the Representative Concentration Pathways

    NARCIS (Netherlands)

    Chuwah, C.; van Noije, T.; van Vuuren, D.P.; Hazeleger, W.; Strunk, A.; Deetman, S.; Beltran, A.M.; van Vliet, J.

    2013-01-01

    The uncertain, future development of emissions of short-lived trace gases and aerosols forms a key factor for future air quality and climate forcing. The Representative Concentration Pathways (RCPs) only explore part of this range as they all assume that worldwide ambitious air pollution control pol

  10. Developing spatially explicit footprints of plausible land-use scenarios in the Santa Cruz Watershed, Arizona and Sonora

    Science.gov (United States)

    Norman, Laura M.; Feller, Mark; Villarreal, Miguel L.

    2012-01-01

    The SLEUTH urban growth model is applied to a binational dryland watershed to envision and evaluate plausible future scenarios of land use change into the year 2050. Our objective was to create a suite of geospatial footprints portraying potential land use change that can be used to aid binational decision-makers in assessing the impacts relative to sustainability of natural resources and potential socio-ecological consequences of proposed land-use management. Three alternatives are designed to simulate different conditions: (i) a Current Trends Scenario of unmanaged exponential growth, (ii) a Conservation Scenario with managed growth to protect the environment, and (iii) a Megalopolis Scenario in which growth is accentuated around a defined international trade corridor. The model was calibrated with historical data extracted from a time series of satellite images. Model materials, methodology, and results are presented. Our Current Trends Scenario predicts the footprint of urban growth to approximately triple from 2009 to 2050, which is corroborated by local population estimates. The Conservation Scenario results in protecting 46% more of the Evergreen class (more than 150,000 acres) than the Current Trends Scenario and approximately 95,000 acres of Barren Land, Crops, Deciduous Forest (Mesquite Bosque), Grassland/Herbaceous, Urban/Recreational Grasses, and Wetlands classes combined. The Megalopolis Scenario results also depict the preservation of some of these land-use classes compared to the Current Trends Scenario, most notably in the environmentally important headwaters region. Connectivity and areal extent of land cover types that provide wildlife habitat were preserved under the alternative scenarios when compared to Current Trends.

  11. Joint Intelligence Analysis Complex: DOD Partially Used Best Practices for Analyzing Alternatives and Should Do So Fully for Future Military Construction Decisions

    Science.gov (United States)

    2016-09-01

    JOINT INTELLIGENCE ANALYSIS COMPLEX DOD Partially Used Best Practices for Analyzing Alternatives and Should Do So Fully for Future...GAO Found The Department of Defense’s (DOD) decision to consolidate and relocate its Joint Intelligence Analysis Complex (JIAC) to Royal Air Force...processes. GAO continues to believe that its recommendation is valid, as discussed in this report. Page i GAO-16-853 Joint Intelligence Analysis Complex

  12. Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences.

    Science.gov (United States)

    Derr, Julien; Manapat, Michael L; Rajamani, Sudha; Leu, Kevin; Xulvi-Brunet, Ramon; Joseph, Isaac; Nowak, Martin A; Chen, Irene A

    2012-05-01

    During the origin of life, the biological information of nucleic acid polymers must have increased to encode functional molecules (the RNA world). Ribozymes tend to be compositionally unbiased, as is the vast majority of possible sequence space. However, ribonucleotides vary greatly in synthetic yield, reactivity and degradation rate, and their non-enzymatic polymerization results in compositionally biased sequences. While natural selection could lead to complex sequences, molecules with some activity are required to begin this process. Was the emergence of compositionally diverse sequences a matter of chance, or could prebiotically plausible reactions counter chemical biases to increase the probability of finding a ribozyme? Our in silico simulations using a two-letter alphabet show that template-directed ligation and high concatenation rates counter compositional bias and shift the pool toward longer sequences, permitting greater exploration of sequence space and stable folding. We verified experimentally that unbiased DNA sequences are more efficient templates for ligation, thus increasing the compositional diversity of the pool. Our work suggests that prebiotically plausible chemical mechanisms of nucleic acid polymerization and ligation could predispose toward a diverse pool of longer, potentially structured molecules. Such mechanisms could have set the stage for the appearance of functional activity very early in the emergence of life.

  13. From Technology-Driven Society to Socially Oriented Technology. The Future of Information Society -- Alternatives to Surveillance

    CERN Document Server

    Helbing, Dirk

    2013-01-01

    Our society is changing. Almost nothing these days works without a computer chip. Computing power doubles every 18 months, and in ten years it will probably exceed the capabilities of a human brain. Computers perform approximately 70 percent of all financial transactions today and IBM's Watson now seems to give better customer advise than some human telephone hotlines. What does this imply for our future society?

  14. Beyond conventional antibiotics for the future treatment of methicillin-resistant Staphylococcus aureus infections: two novel alternatives.

    LENUS (Irish Health Repository)

    Fitzgerald-Hughes, Deirdre

    2012-08-01

    The majority of antibiotics currently used to treat methicillin-resistant Staphylococus aureus (MRSA) infections target bacterial cell wall synthesis or protein synthesis. Only daptomycin has a novel mode of action. Reliance on limited targets for MRSA chemotherapy, has contributed to antimicrobial resistance. Two alternative approaches to the treatment of S. aureus infection, particularly those caused by MRSA, that have alternative mechanisms of action and that address the challenge of antimicrobial resistance are cationic host defence peptides and agents that target S. aureus virulence. Cationic host defence peptides have multiple mechanisms of action and are less likely than conventional agents to select resistant mutants. They are amenable to modifications that improve their stability, effectiveness and selectivity. Some cationic defence peptides such as bactenecin, mucroporin and imcroporin have potent in vitro bactericidal activity against MRSA. Antipathogenic agents also have potential to limit the pathogenesis of S aureus. These are generally small molecules that inhibit virulence targets in S. aureus without killing the bacterium and therefore have limited capacity to promote resistance development. Potential antipathogenic targets include the sortase enzyme system, the accessory gene regulator (agr) and the carotenoid biosynthetic pathway. Inhibitors of these targets have been identified and these may have potential for further development.

  15. Reciprocity-based reasons for benefiting research participants: most fail, the most plausible is problematic.

    Science.gov (United States)

    Sofaer, Neema

    2014-11-01

    A common reason for giving research participants post-trial access (PTA) to the trial intervention appeals to reciprocity, the principle, stated most generally, that if one person benefits a second, the second should reciprocate: benefit the first in return. Many authors consider it obvious that reciprocity supports PTA. Yet their reciprocity principles differ, with many authors apparently unaware of alternative versions. This article is the first to gather the range of reciprocity principles. It finds that: (1) most are false. (2) The most plausible principle, which is also problematic, applies only when participants experience significant net risks or burdens. (3) Seldom does reciprocity support PTA for participants or give researchers stronger reason to benefit participants than equally needy non-participants. (4) Reciprocity fails to explain the common view that it is bad when participants in a successful trial have benefited from the trial intervention but lack PTA to it.

  16. A Biomass-based Model to Estimate the Plausibility of Exoplanet Biosignature Gases

    CERN Document Server

    Seager, S; Hu, R

    2013-01-01

    Biosignature gas detection is one of the ultimate future goals for exoplanet atmosphere studies. We have created a framework for linking biosignature gas detectability to biomass estimates, including atmospheric photochemistry and biological thermodynamics. The new framework is intended to liberate predictive atmosphere models from requiring fixed, Earth-like biosignature gas source fluxes. New biosignature gases can be considered with a check that the biomass estimate is physically plausible. We have validated the models on terrestrial production of NO, H2S, CH4, CH3Cl, and DMS. We have applied the models to propose NH3 as a biosignature gas on a "cold Haber World," a planet with a N2-H2 atmosphere, and to demonstrate why gases such as CH3Cl must have too large of a biomass to be a plausible biosignature gas on planets with Earth or early-Earth-like atmospheres orbiting a Sun-like star. To construct the biomass models, we developed a functional classification of biosignature gases, and found that gases (such...

  17. Implications of Climate Change for Bird Conservation in the Southwestern U.S. under Three Alternative Futures.

    Directory of Open Access Journals (Sweden)

    Megan M Friggens

    Full Text Available Future expected changes in climate and human activity threaten many riparian habitats, particularly in the southwestern U.S. Using Maximum Entropy (MaxEnt3.3.3 modeling, we characterized habitat relationships and generated spatial predictions of habitat suitability for the Lucy's warbler (Oreothlypis luciae, the Southwestern willow flycatcher (Empidonax traillii extimus and the Western yellow-billed cuckoo (Coccyzus americanus. Our goal was to provide site- and species-specific information that can be used by managers to identify areas for habitat conservation and/or restoration along the Rio Grande in New Mexico. We created models of suitable habitat for each species based on collection and survey samples and climate, biophysical, and vegetation data. We projected habitat suitability under future climates by applying these models to conditions generated from three climate models for 2030, 2060 and 2090. By comparing current and future distributions, we identified how habitats are likely to change as a result of changing climate and the consequences of those changes for these bird species. We also examined whether land ownership of high value sites shifts under changing climate conditions. Habitat suitability models performed well. Biophysical characteristics were more important that climate conditions for predicting habitat suitability with distance to water being the single most important predictor. Climate, though less important, was still influential and led to declines of suitable habitat of more than 60% by 2090. For all species, suitable habitat tended to shrink over time within the study area leaving a few core areas of high importance. Overall, climate changes will increase habitat fragmentation and reduce breeding habitat patch size. The best strategy for conserving bird species within the Rio Grande will include measures to maintain and restore critical habitat refugia. This study provides an example of a presence-only habitat model

  18. Transportation Energy Futures Series: Alternative Fuel Infrastructure Expansion: Costs, Resources, Production Capacity, and Retail Availability for Low-Carbon Scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Melaina, W. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Heath, Garvin [National Renewable Energy Lab. (NREL), Golden, CO (United States); Sandor, Debra [National Renewable Energy Lab. (NREL), Golden, CO (United States); Steward, Darlene [National Renewable Energy Lab. (NREL), Golden, CO (United States); Vimmerstedt, Laura [National Renewable Energy Lab. (NREL), Golden, CO (United States); Warner, Ethan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Webster, Karen W. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2013-04-01

    The petroleum-based transportation fuel system is complex and highly developed, in contrast to the nascent low-petroleum, low-carbon alternative fuel system. This report examines how expansion of the low-carbon transportation fuel infrastructure could contribute to deep reductions in petroleum use and greenhouse gas (GHG) emissions across the U.S. transportation sector. Three low-carbon scenarios, each using a different combination of low-carbon fuels, were developed to explore infrastructure expansion trends consistent with a study goal of reducing transportation sector GHG emissions to 80% less than 2005 levels by 2050.These scenarios were compared to a business-as-usual (BAU) scenario and were evaluated with respect to four criteria: fuel cost estimates, resource availability, fuel production capacity expansion, and retail infrastructure expansion.

  19. On the biological plausibility of Wind Turbine Syndrome.

    Science.gov (United States)

    Harrison, Robert V

    2015-01-01

    An emerging environmental health issue relates to potential ill-effects of wind turbine noise. There have been numerous suggestions that the low-frequency acoustic components in wind turbine signals can cause symptoms associated with vestibular system disorders, namely vertigo, nausea, and nystagmus. This constellation of symptoms has been labeled as Wind Turbine Syndrome, and has been identified in case studies of individuals living close to wind farms. This review discusses whether it is biologically plausible for the turbine noise to stimulate the vestibular parts of the inner ear and, by extension, cause Wind Turbine Syndrome. We consider the sound levels that can activate the semicircular canals or otolith end organs in normal subjects, as well as in those with preexisting conditions known to lower vestibular threshold to sound stimulation.

  20. Hamiltonian formulation of time-dependent plausible inference

    CERN Document Server

    Davis, Sergio

    2014-01-01

    Maximization of the path information entropy is a clear prescription for performing time-dependent plausible inference. Here it is shown that, following this prescription under the assumption of arbitrary instantaneous constraints on position and velocity, a Lagrangian emerges which determines the most probable trajectory. Deviations from the probability maximum can be consistently described as slices in time by a Hamiltonian, according to a nonlinear Langevin equation and its associated Fokker-Planck equation. The connections unveiled between the maximization of path entropy and the Langevin/Fokker-Planck equations imply that missing information about the phase space coordinate never decreases in time, a purely information-theoretical version of the Second Law of Thermodynamics. All of these results are independent of any physical assumptions, and thus valid for any generalized coordinate as a function of time, or any other parameter. This reinforces the view that the Second Law is a fundamental property of ...

  1. Alkaloids from Pandanus amaryllifolius: Isolation and Their Plausible Biosynthetic Formation.

    Science.gov (United States)

    Tsai, Yu-Chi; Yu, Meng-Lun; El-Shazly, Mohamed; Beerhues, Ludger; Cheng, Yuan-Bin; Chen, Lei-Chin; Hwang, Tsong-Long; Chen, Hui-Fen; Chung, Yu-Ming; Hou, Ming-Feng; Wu, Yang-Chang; Chang, Fang-Rong

    2015-10-23

    Pandanus amaryllifolius Roxb. (Pandanaceae) is used as a flavor and in folk medicine in Southeast Asia. The ethanolic crude extract of the aerial parts of P. amaryllifolius exhibited antioxidant, antibiofilm, and anti-inflammatory activities in previous studies. In the current investigation, the purification of the ethanolic extract yielded nine new compounds, including N-acetylnorpandamarilactonines A (1) and B (2); pandalizines A (3) and B (4); pandanmenyamine (5); pandamarilactones 2 (6) and 3 (7), and 5(E)-pandamarilactonine-32 (8); and pandalactonine (9). The isolated alkaloids, with either a γ-alkylidene-α,β-unsaturated-γ-lactone or γ-alkylidene-α,β-unsaturated-γ-lactam system, can be classified into five skeletons including norpandamarilactonine, indolizinone, pandanamine, pandamarilactone, and pandamarilactonine. A plausible biosynthetic route toward 1-5, 7, and 9 is proposed.

  2. Complex Learning in Bio-plausible Memristive Networks.

    Science.gov (United States)

    Deng, Lei; Li, Guoqi; Deng, Ning; Wang, Dong; Zhang, Ziyang; He, Wei; Li, Huanglong; Pei, Jing; Shi, Luping

    2015-06-19

    The emerging memristor-based neuromorphic engineering promises an efficient computing paradigm. However, the lack of both internal dynamics in the previous feedforward memristive networks and efficient learning algorithms in recurrent networks, fundamentally limits the learning ability of existing systems. In this work, we propose a framework to support complex learning functions by introducing dedicated learning algorithms to a bio-plausible recurrent memristive network with internal dynamics. We fabricate iron oxide memristor-based synapses, with well controllable plasticity and a wide dynamic range of excitatory/inhibitory connection weights, to build the network. To adaptively modify the synaptic weights, the comprehensive recursive least-squares (RLS) learning algorithm is introduced. Based on the proposed framework, the learning of various timing patterns and a complex spatiotemporal pattern of human motor is demonstrated. This work paves a new way to explore the brain-inspired complex learning in neuromorphic systems.

  3. Mapping alternative energy paths for taiwan to reach a sustainable future: An application of the leap model

    Science.gov (United States)

    Chen, Wei-Ming

    Energy is the backbone of modern life which is highly related to national security, economic growth, and environmental protection. For Taiwan, a region having limited conventional energy resources but constructing economies and societies with high energy intensity, energy became the throat of national security and development. This dissertation explores energy solutions for Taiwan by constructing a sustainable and comprehensive energy planning framework (SCENE) and by simulating alternative energy pathways on the horizon to 2030. The Long-range Energy Alternatives Planning system (LEAP) is used as a platform for the energy simulation. The study models three scenarios based on the E4 (energy -- environment -- economic -- equity) perspectives. Three scenarios refer to the business-as-usual scenario (BAU), the government target scenario (GOV), and the renewable and efficiency scenario (REEE). The simulation results indicate that the most promising scenario for Taiwan is the REEE scenario, which aims to save 48.7 million tonnes of oil equivalent (Mtoe) of final energy consumption. It avoids USD 11.1 billion on electricity expenditure in final demand sectors. In addition, the cost of the REEE path is the lowest among all scenarios before 2020 in the electricity generation sector. In terms of global warming potential (GWP), the REEE scenario could reduce 35 percent of the GWP in the demand sectors, the lowest greenhouse gases emission in relation to all other scenarios. Based on lowest energy consumption, competitive cost, and least harm to the environment, the REEE scenario is the best option to achieve intergenerational equity. This dissertation proposes that promoting energy efficiency and utilizing renewable energy is the best strategy for Taiwan. For efficiency improvement, great energy saving potentials do exist in Taiwan so that Taiwan needs more ambitious targets, policies, and implementation mechanisms for energy efficiency enhancement to slow down and decrease

  4. Evaluation of unthrottled combustion system options for light duty applications with future syncrude derived fuels. Alternative Fuels Utilization Program

    Energy Technology Data Exchange (ETDEWEB)

    Needham, J. R.; Cooper, B. M.; Norris-Jones, S. R.

    1982-12-01

    An experimental program examining the interaction between several fuel and light duty automotive engine combinations is detailed. Combustion systems addressed covered indirect and direct injection diesel and spark ignited stratified charge. Fuels primarily covered D2, naphtha and intermediate broadcut blends. Low ignition quality diesel fuels were also evaluated. The results indicate the baseline fuel tolerance of each combustion system and enable characteristics of the systems to be compared. Performance, gaseous and particulate emissions aspects were assessed. The data obtained assists in the selection of candidate combustion systems for potential future fuels. Performance and environmental penalties as appropriate are highlighted relative to the individual candidates. Areas of further work for increased understanding are also reviewed.

  5. Final report study of alternatives for future operations of the naval petroleum and oil shale reserves NPR-2, California

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-01

    The US Department of Energy (DOE) has asked Gustavson Associates, Inc. to serve as an Independent Petroleum Consultant under contract DE-AC01-96FE64202. This authorizes a study and recommendations regarding future development of Naval Petroleum Reserve No. 2 (NPR-2) in Kern County, California. The report that follows is the Phase II Final Report for that study. Additional details are provided in the Addendum (the Phase I Property Description and Fact Finding Report). The key property elements that positively affect the estimated value of NPR-2 include the following: royalty income from producing oil and gas leases, rental income from non-producing oil and gas leases, income from grazing or leasing of grazing rights, potential income from oil and gas leasing on exploratory (or nonprospective) acreage, potential value of trading surface real estate as ranch land for sheep grazing (10,044 acres), and town lots for residential or commercial development (16.7 acres). Key elements that negatively impact the estimated value include: environmental assessment costs, operating budgets, and lease sale expenses.

  6. Transportation Energy Futures Series: Alternative Fuel Infrastructure Expansion: Costs, Resources, Production Capacity, and Retail Availability for Low-Carbon Scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Melaina, M. W.; Heath, G.; Sandor, D.; Steward, D.; Vimmerstedt, L.; Warner, E.; Webster, K. W.

    2013-04-01

    Achieving the Department of Energy target of an 80% reduction in greenhouse gas emissions by 2050 depends on transportation-related strategies combining technology innovation, market adoption, and changes in consumer behavior. This study examines expanding low-carbon transportation fuel infrastructure to achieve deep GHG emissions reductions, with an emphasis on fuel production facilities and retail components serving light-duty vehicles. Three distinct low-carbon fuel supply scenarios are examined: Portfolio: Successful deployment of a range of advanced vehicle and fuel technologies; Combustion: Market dominance by hybridized internal combustion engine vehicles fueled by advanced biofuels and natural gas; Electrification: Market dominance by electric drive vehicles in the LDV sector, including battery electric, plug-in hybrid, and fuel cell vehicles, that are fueled by low-carbon electricity and hydrogen. A range of possible low-carbon fuel demand outcomes are explored in terms of the scale and scope of infrastructure expansion requirements and evaluated based on fuel costs, energy resource utilization, fuel production infrastructure expansion, and retail infrastructure expansion for LDVs. This is one of a series of reports produced as a result of the Transportation Energy Futures (TEF) project, a Department of Energy-sponsored multi-agency project initiated to pinpoint underexplored transportation-related strategies for abating GHGs and reducing petroleum dependence.

  7. Liderazgo preventivo para la universidad. Una experiencia plausible

    Directory of Open Access Journals (Sweden)

    Alejandro Rodríguez Rodríguez

    2015-06-01

    Full Text Available El desarrollo del liderazgo, en el ámbito educativo superior, busca soluciones de aplicación inmediata a contextos en que todo líder se desenvuelve, pero se diluye el sustento teórico-práctico en la formación del líder que posibilite entender los procesos intelectivos durante la toma de decisiones. El paradigma de convergencia entre el método antropológico lonerganiano, la comunidad de aprendizaje vygotskiana y una relectura del sistema preventivo salesiano se presentan como propuesta plausible de formación al liderazgo preventivo entre los diversos actores de una comunidad universitaria. Un estudio de caso de la Universidad Salesiana en México empleando un método mixto de investigación, facilita una relectura del liderazgo desde una óptica preventiva como posibilidad de convergencia en un diálogo interdisciplinar. Los resultados teórico-práctico propuestos y examinados se muestran como herramienta útil para evaluar, enriquecer y renovar la teoría sobre el líder y el desarrollo de liderazgo en las universidades frente a una sociedad globalizada.

  8. A perspective on SIDS pathogenesis. The hypotheses: plausibility and evidence

    Directory of Open Access Journals (Sweden)

    Goldwater Paul N

    2011-05-01

    Full Text Available Abstract Several theories of the underlying mechanisms of Sudden Infant Death Syndrome (SIDS have been proposed. These theories have born relatively narrow beach-head research programs attracting generous research funding sustained for many years at expense to the public purse. This perspective endeavors to critically examine the evidence and bases of these theories and determine their plausibility; and questions whether or not a safe and reasoned hypothesis lies at their foundation. The Opinion sets specific criteria by asking the following questions: 1. Does the hypothesis take into account the key pathological findings in SIDS? 2. Is the hypothesis congruent with the key epidemiological risk factors? 3. Does it link 1 and 2? Falling short of any one of these answers, by inference, would imply insufficient grounds for a sustainable hypothesis. Some of the hypotheses overlap, for instance, notional respiratory failure may encompass apnea, prone sleep position, and asphyxia which may be seen to be linked to co-sleeping. For the purposes of this paper, each element will be assessed on the above criteria.

  9. Direct current in the future. HVDC better than a high-voltage alternating current cable; Gelijk in de toekomst. HVDC-verbonding beter dan hoogspanningskabel met wisselstroom

    Energy Technology Data Exchange (ETDEWEB)

    Van Velzen, T.

    2010-10-01

    For the development of a pan-European high-voltage grid the application of direct current (DC) technology is obvious. However, a series of incidents involving a link between the Netherlands and Norway raises questions about the reliability. An alternative conversion method seems more suited for a European supernetwork. DC transmission with insulated-gate bipolar transistor is the technology of the future. [Dutch] Voor de ontwikkeling van een pan-Europees hoogspanningsnet ligt toepassing van gelijkstroomtechnologie voor de hand. Een reeks incidenten met zo'n verbinding tussen Nederland en Noorwegen roept echter vragen op over de betrouwbaarheid. Een alternatieve conversietechniek lijkt echter geschikter voor een Europees supernet. Gelijkstroomtransmissie met 'insulated-gate bipolar' transistors is de techniek van de toekomst.

  10. A biologically plausible embodied model of action discovery

    Directory of Open Access Journals (Sweden)

    Rufino eBolado-Gomez

    2013-03-01

    Full Text Available During development, animals can spontaneously discover action-outcomepairings enabling subsequent achievement of their goals. We present abiologically plausible embodied model addressing key aspects of thisprocess. The biomimetic model core comprises the basal ganglia and itsloops through cortex and thalamus. We incorporate reinforcementlearning with phasic dopamine supplying a sensory prediction error,signalling 'surprising' outcomes. Phasic dopamine is used in acorticostriatal learning rule which is consistent with recent data. Wealso hypothesised that objects associated with surprising outcomesacquire 'novelty salience' contingent on the predicability of theoutcome. To test this idea we used a simple model of predictiongoverning the dynamics of novelty salience and phasic dopamine. Thetask of the virtual robotic agent mimicked an in vivo counterpart(Gancarz et al., 2011 and involved interaction with a target objectwhich caused a light flash, or a control object which did not.Learning took place according to two schedules. In one, the phasicoutcome was delivered after interaction with the target in anunpredictable way which emulated the in vivo protocol. Without noveltysalience, the model was unable to account for the experimental data.In the other schedule, the phasic outcome was reliably delivered andthe agent showed a rapid increase in the number of interactions withthe target which then decreased over subsequent sessions. We arguethis is precisely the kind of change in behaviour required torepeatedly present representations of context, action and outcome, toneural networks responsible for learning action-outcome contingency.The model also showed corticostriatal plasticity consistent withlearning a new action in basal ganglia. We conclude that actionlearning is underpinned by a complex interplay of plasticity andstimulus salience, and that our model contains many of the elementsfor biological action discovery to take place.

  11. Changing beliefs about implausible autobiographical events: a little plausibility goes a long way.

    Science.gov (United States)

    Mazzoni, G A; Loftus, E F; Kirsch, I

    2001-03-01

    Three experiments investigated the malleability of perceived plausibility and the subjective likelihood of occurrence of plausible and implausible events among participants who had no recollection of experiencing them. In Experiment 1, a plausibility-enhancing manipulation (reading accounts of the occurrence of events) combined with a personalized suggestion increased the perceived plausibility of the implausible event, as well as participants' ratings of the likelihood that they had experienced it. Plausibility and likelihood ratings were uncorrelated. Subsequent studies showed that the plausibility manipulation alone was sufficient to increase likelihood ratings but only if the accounts that participants read were set in a contemporary context. These data suggest that false autobiographical beliefs can be induced in clinical and forensic contexts even for initially implausible events.

  12. Risk, Resilience, and Alternative Futures

    DEFF Research Database (Denmark)

    Garsten, Christina; Sörbom, Adrienne

    The implications of globalization and geopolitical shifts are central concerns in think tanks and other organizations geared to producing knowledge about the contemporary world. The World Economic Forum, a nonprofit international organization headquartered in Geneva, concentrates a large part...

  13. Co-producing Coastal Adaptation Plans with Pacific Northwest Stakeholders: Applying Alternative Futures Analysis to Quantitatively Envision Policy and Climate Scenarios

    Science.gov (United States)

    Evans-Wilent, J.; Ruggiero, P.; Bolte, J.; Serafin, K.; Stevenson, J.; Schwartz, C.

    2016-12-01

    Coastal communities throughout the US West Coast and elsewhere are facing the daunting task of preparing for climate change impacts, particularly the hazards from increased flooding and erosion. With sea-level rise, changing storminess patterns, and possible changes to the frequency and severity of major El Niño events, communities are already implementing emergency responses in order to protect infrastructure, beach access, and property. Recent studies show that despite the vast information available on coastal hazards and expected risks, few coastal adaptation plans with long-term climate change planning have been successfully implemented. Most likely, this lack of implementation is due to a disconnect between scientists and decision-makers; despite the availability of relevant science and tools, local decision-makers are burdened by not only deciphering the scientific information but also executing complex and costly coastal adaptation strategies without clear quantitative analysis at a regional level. Our approach to increasing the usability of coastal adaptation planning is to co-develop decision-support tools with `Knowledge to Action Networks' (KTANs) and use Envision, a multi agent-based framework for modeling alternative futures. In this study, we review the co-produced coastal adaptation policies being explored by KTANs in both Tillamook County, OR and Grays Harbor County, WA, two regions of the US West Coast that have experienced vastly different coastal evolution in the last few decades and therefore have significant differences in their exposure to coastal flood and erosion hazards. We examine how variations in local priorities drive the co-development of different policy scenarios across the two locations, and how metrics of importance to local stakeholders (e.g., the number of buildings impacted by flooding) change over time under different climate and policy scenarios. We also compare the influence of human-decision making via policy implementation

  14. Is the de Broglie-Bohm interpretation of quantum mechanics really plausible?

    Science.gov (United States)

    Jung, Kurt

    2013-06-01

    Bohmian mechanics also known as de Broglie-Bohm theory is the most popular alternative approach to quantum mechanics. Whereas the standard interpretation of quantum mechanics is based on the complementarity principle Bohmian mechanics assumes that both particle and wave are concrete physical objects. In 1993 Peter Holland has written an ardent account on the plausibility of the de Broglie-Bohm theory. He proved that it fully reproduces quantum mechanics if the initial particle distribution is consistent with a solution of the Schrödinger equation. Which may be the reasons that Bohmian mechanics has not yet found global acceptance? In this article it will be shown that predicted properties of atoms and molecules are in conflict with experimental findings. Moreover it will be demonstrated that repeatedly published ensembles of trajectories illustrating double slit diffraction processes do not agree with quantum mechanics. The credibility of a theory is undermined when recognizably wrong data presented frequently over years are finally not declared obsolete.

  15. A FRAME response to the Draft Report on Alternative (Non-animal) Methods for Cosmetics Testing: Current Status and Future Prospects--2010.

    Science.gov (United States)

    Balls, Michael; Clothier, Richard

    2010-10-01

    This response on behalf of FRAME to the European Commission's consultation on the five chapters of the Draft Report on Alternative (Non-animal) Methods for Cosmetics Testing: Current Status and Future Prospects--2010, is via a Comment in ATLA, rather than via the template supplied by the Commission. This is principally so that a number of general points about cosmetic ingredient testing can be made. It is concluded that the five draft chapters do not provide a credible basis for the Commission's forthcoming report to the European Parliament and the European Council on the five cosmetic ingredient safety issues for which the 7th Amendment to the Cosmetic Directive's ban on animal testing was postponed until 2013. This is mainly because there is insufficient focus in the draft chapters on the specific nature of cosmetic ingredients, their uses, their local effects and metabolism at their sites of application, and, in particular, on whether their possible absorption into the body would be likely to lead to their accumulation in target sites at levels approaching Thresholds of Toxicological Concern. Meanwhile, there continues to be uncertainty about how the provisions of the Cosmetics Directive should be applied, given the requirements of the REACH system and directives concerned with the safety of other chemicals and products. © 2010 FRAME.

  16. Climate change, resource use and food security in midcentury under a range of plausible scenarios

    Science.gov (United States)

    Wiebe, K.

    2016-12-01

    Achieving and maintaining food security at local, national and global scales is challenged by changes in population, income and climate, among other socioeconomic and biophysical drivers. Assessing these challenges and possible solutions over the coming decades requires a systematic and multidisciplinary approach. The Global Futures and Strategic Foresight program, a CGIAR initiative led by the International Food Policy Research Institute in collaboration with the 14 other CGIAR research centers, is working to improve tools and conduct ex ante assessments of promising technologies, investments and policies under alternative global futures to inform decision making in the CGIAR and its partners. Alternative socioeconomic and climate scenarios are explored using an integrated system of climate, water, crop and economic models. This presentation will share findings from recent projections of food production and prices to 2050 at global and regional scales, together with their potential implications for land and water use, food security, nutrition and health.

  17. The Utility of Cognitive Plausibility in Language Acquisition Modeling: Evidence From Word Segmentation

    National Research Council Canada - National Science Library

    Phillips, Lawrence; Pearl, Lisa

    2015-01-01

    The informativity of a computational model of language acquisition is directly related to how closely it approximates the actual acquisition task, sometimes referred to as the model's cognitive plausibility...

  18. The Utility of Cognitive Plausibility in Language Acquisition Modeling: Evidence From Word Segmentation.

    Science.gov (United States)

    Phillips, Lawrence; Pearl, Lisa

    2015-11-01

    The informativity of a computational model of language acquisition is directly related to how closely it approximates the actual acquisition task, sometimes referred to as the model's cognitive plausibility. We suggest that though every computational model necessarily idealizes the modeled task, an informative language acquisition model can aim to be cognitively plausible in multiple ways. We discuss these cognitive plausibility checkpoints generally and then apply them to a case study in word segmentation, investigating a promising Bayesian segmentation strategy. We incorporate cognitive plausibility by using an age-appropriate unit of perceptual representation, evaluating the model output in terms of its utility, and incorporating cognitive constraints into the inference process. Our more cognitively plausible model shows a beneficial effect of cognitive constraints on segmentation performance. One interpretation of this effect is as a synergy between the naive theories of language structure that infants may have and the cognitive constraints that limit the fidelity of their inference processes, where less accurate inference approximations are better when the underlying assumptions about how words are generated are less accurate. More generally, these results highlight the utility of incorporating cognitive plausibility more fully into computational models of language acquisition.

  19. Making the future memorable: The phenomenology of remembered future events.

    Science.gov (United States)

    McLelland, Victoria C; Devitt, Aleea L; Schacter, Daniel L; Addis, Donna Rose

    2015-01-01

    Although our ability to remember future simulations conveys an adaptive advantage, enabling us to better prepare for upcoming events, the factors influencing the memorability of future simulations are not clear. In this study, participants generated future simulations that combined specific people, places and objects from memory, and for each trial, made a series of phenomenological ratings about the event components and the simulation as a whole. Memory for simulations was later assessed using a cued-recall test. We used multilevel modelling to determine whether the phenomenological qualities of event components (familiarity, emotionality and significance) and simulations (detail, plausibility) were predictive of whether the simulation was successfully encoded and later accessible. Our results demonstrate that person familiarity, detail and plausibility were significant predictors of whether a given future simulation was encoded into memory and later accessible. These findings suggest that scaffolding future simulations with pre-existing episodic memories is the path to a memorable future.

  20. A hitherto undescribed case of cerebellar ataxia as the sole presentation of thyrotoxicosis in a young man: a plausible association.

    Science.gov (United States)

    Elhadd, Tarik Abdelkareim; Linton, Kathryn; McCoy, Caoihme; Saha, Subrata; Holden, Roger

    2014-01-01

    A 16-year-old male presented to hospital following an episode of unusual behavior on the football pitch, where he was witnessed as grossly ataxic by his teammates. The assessment demonstrated marked cerebellar signs on examination but no other neurological deficit. The investigation showed the evidence of biochemical thyrotoxicosis with free T4 at 37 pmol/L (normal reference range: 11-27) and thyrotropin (TSH) plausible because alternative etiologies were excluded, and the normalization of thyroid function with treatment was coupled with complete resolution of the neurological syndrome. Cerebellar syndromes may well be one of the presenting features of thyrotoxicosis, and this should be in the list of its differential diagnosis.

  1. Interactions between visual and motor areas during the recognition of plausible actions as revealed by magnetoencephalography.

    Science.gov (United States)

    Pavlidou, Anastasia; Schnitzler, Alfons; Lange, Joachim

    2014-02-01

    Several studies have shown activation of the mirror neuron system (MNS), comprising the temporal, posterior parietal, and sensorimotor areas when observing plausible actions, but far less is known on how these cortical areas interact during the recognition of a plausible action. Here, we recorded neural activity with magnetoencephalography while subjects viewed point-light displays of biologically plausible and scrambled versions of actions. We were interested in modulations of oscillatory activity and, specifically, in coupling of oscillatory activity between visual and motor areas. Both plausible and scrambled actions elicited modulations of θ (5-7 Hz), α (7-13 Hz), β (13-35 Hz), and γ (55-100 Hz) power within visual and motor areas. When comparing between the two actions, we observed sequential and spatially distinct increases of γ (∼65 Hz), β (∼25 Hz), and α (∼11 Hz) power between 0.5 and 1.3 s in parieto-occipital, sensorimotor, and left temporal areas. In addition, significant clusters of γ (∼65 Hz) and α/β (∼15 Hz) power decrease were observed in right temporal and parieto-occipital areas between 1.3 and 2.0 s. We found β-power in sensorimotor areas to be positively correlated on a trial-by-trial basis with parieto-occipital γ and left temporal α-power for the plausible but not for the scrambled condition. These results provide new insights in the neuronal oscillatory activity of the areas involved in the recognition of plausible action movements and their interaction. The power correlations between specific areas underscore the importance of interactions between visual and motor areas of the MNS during the recognition of a plausible action.

  2. Stereotyping to infer group membership creates plausible deniability for prejudice-based aggression.

    Science.gov (United States)

    Cox, William T L; Devine, Patricia G

    2014-02-01

    In the present study, participants administered painful electric shocks to an unseen male opponent who was either explicitly labeled as gay or stereotypically implied to be gay. Identifying the opponent with a gay-stereotypic attribute produced a situation in which the target's group status was privately inferred but plausibly deniable to others. To test the plausible deniability hypothesis, we examined aggression levels as a function of internal (personal) and external (social) motivation to respond without prejudice. Whether plausible deniability was present or absent, participants high in internal motivation aggressed at low levels, and participants low in both internal and external motivation aggressed at high levels. The behavior of participants low in internal and high in external motivation, however, depended on experimental condition. They aggressed at low levels when observers could plausibly attribute their behavior to prejudice and aggressed at high levels when the situation granted plausible deniability. This work has implications for both obstacles to and potential avenues for prejudice-reduction efforts.

  3. The future role of alternative powertrains and fuels in the German transport sector : a model based scenario analysis with respect to technical, economic and environmental aspects with a focus on road transport

    OpenAIRE

    Özdemir, Enver Doruk

    2012-01-01

    The transport sector is facing the challenges of satisfying the ever increasing transport demand on the one hand and achieving greenhouse gas (GHG) emission reduction targets without compromising economic development on the other hand. There are various alternative fuels and powertrains which might play a role in the future of the German transport sector. Amongst these options, biofuels are considered to help lower GHG emissions. However, they are severely criticized to create an additional s...

  4. Alternative energies. Alternative Energien

    Energy Technology Data Exchange (ETDEWEB)

    Hayes, D.

    1979-01-01

    This is a popular review of problems of present and, in particular, future energy supply. All energy sources available are discussed, including improved energy use and energy conservation. Solar energy is favoured as energy source of the future. A great number of examples are given along with many bibliographic references.

  5. Don't Plan for the Unexpected: Planning Based on Plausibility Models

    DEFF Research Database (Denmark)

    Andersen, Mikkel Birkegaard; Bolander, Thomas; Jensen, Martin Holm

    2015-01-01

    We present a framework for automated planning based on plausibility models, as well as algorithms for computing plans in this framework. Our plausibility models include postconditions, as ontic effects are essential for most planning purposes. The framework presented extends a previously developed...... framework based on dynamic epistemic logic (DEL), without plausibilities/beliefs. In the pure epistemic framework, one can distinguish between strong and weak epistemic plans for achieving some, possibly epistemic, goal. By taking all possible outcomes of actions into account, a strong plan guarantees...... that the agent achieves this goal. Conversely, a weak plan promises only the possibility of leading to the goal. In real-life planning scenarios where the planning agent is faced with a high degree of uncertainty and an almost endless number of possible exogenous events, strong epistemic planning...

  6. Inference and Plausible Reasoning in a Natural Language Understanding System Based on Object-Oriented Semantics

    CERN Document Server

    Ostapov, Yuriy

    2012-01-01

    Algorithms of inference in a computer system oriented to input and semantic processing of text information are presented. Such inference is necessary for logical questions when the direct comparison of objects from a question and database can not give a result. The following classes of problems are considered: a check of hypotheses for persons and non-typical actions, the determination of persons and circumstances for non-typical actions, planning actions, the determination of event cause and state of persons. To form an answer both deduction and plausible reasoning are used. As a knowledge domain under consideration is social behavior of persons, plausible reasoning is based on laws of social psychology. Proposed algorithms of inference and plausible reasoning can be realized in computer systems closely connected with text processing (criminology, operation of business, medicine, document systems).

  7. The semiosis of prayer and the creation of plausible fictional worlds

    Directory of Open Access Journals (Sweden)

    J. Peter Södergård

    1999-01-01

    Full Text Available Prayer and incantation can perhaps be said to be 'mechanisms' that promise that lack will be liquidated and that there is an unlimited signator, a father, or some other metaphysical creature, standing behind and legitimizing the discourse. A way of communicating with the Unlimited that is privileged by an interpretive community that read the prayers aloud and enacted the magical stage-scripts. These highly overlapping categories function as one of the most common subforms of religious discourse for the creation, actualization and maintenance of plausible fictional worlds. They are liminal and transitional mechanisms that manipulate an empirical reader to phase-shift from an actual world to a plausible, by being inscribed in a possible and fictional world, thus creating a model reader, that perceives and acts according to the plausible world outlined by a given interpretive community, and that hears god talking in voces magicae and in god-speaking silence.

  8. Don't Plan for the Unexpected: Planning Based on Plausibility Models

    DEFF Research Database (Denmark)

    Andersen, Mikkel Birkegaard; Bolander, Thomas; Jensen, Martin Holm

    2015-01-01

    that the agent achieves this goal. Conversely, a weak plan promises only the possibility of leading to the goal. In real-life planning scenarios where the planning agent is faced with a high degree of uncertainty and an almost endless number of possible exogenous events, strong epistemic planning......We present a framework for automated planning based on plausibility models, as well as algorithms for computing plans in this framework. Our plausibility models include postconditions, as ontic effects are essential for most planning purposes. The framework presented extends a previously developed...... framework based on dynamic epistemic logic (DEL), without plausibilities/beliefs. In the pure epistemic framework, one can distinguish between strong and weak epistemic plans for achieving some, possibly epistemic, goal. By taking all possible outcomes of actions into account, a strong plan guarantees...

  9. Incorporating future change into current conservation planning: Evaluating tidal saline wetland migration along the U.S. Gulf of Mexico coast under alternative sea-level rise and urbanization scenarios

    Science.gov (United States)

    Enwright, Nicholas M.; Griffith, Kereen T.; Osland, Michael J.

    2015-11-02

    In this study, the U.S. Geological Survey, in cooperation with the U.S. Fish and Wildlife Service, quantified the potential for landward migration of tidal saline wetlands along the U.S. Gulf of Mexico coast under alternative future sea-level rise and urbanization scenarios. Our analyses focused exclusively on tidal saline wetlands (that is, mangrove forests, salt marshes, and salt flats), and we combined these diverse tidal saline wetland ecosystems into a single grouping, “tidal saline wetland.” Collectively, our approach and findings can provide useful information for scientists and environmental planners working to develop future-focused adaptation strategies for conserving coastal landscapes and the ecosystem goods and services provided by tidal saline wetlands. The primary product of this work is a public dataset that identifies locations where landward migration of tidal saline wetlands is expected to occur under alternative future sea-level rise and urbanization scenarios. In addition to identifying areas where landward migration of tidal saline wetlands is possible because of the absence of barriers, these data also identify locations where landward migration of these wetlands could be prevented by barriers associated with current urbanization, future urbanization, and levees.

  10. Single-Incision Laparoscopic Cholecystectomy: Is It a Plausible Alternative to the Traditional Four-Port Laparoscopic Approach?

    Directory of Open Access Journals (Sweden)

    Juan Pablo Arroyo

    2012-01-01

    Full Text Available The current standard-of-care for treatment of cholecystectomy is the four port laparoscopic approach. The development of single incision/laparoendoscopic single site surgery (SILC/LESS has now led to the development of new techniques for removal of the gallbladder. The use of SILC/LESS is now currently being evaluated as the next step in treatment of cholecystectomy. This review is an attempt to consolidate the current knowledge and analyze the feasibility of world-wide implementation of SILC/LESS.

  11. Remote operation systems and development cooperation, future couple in alternative energy sources; Telegestion y cooperacion al desarrollo, binomio de futuro en energias renovables

    Energy Technology Data Exchange (ETDEWEB)

    Borge Diez, D.

    2008-07-01

    Despite of the rising in the fuel and its by-products, alternative energy sources have not vet developed specially in small plants for local generation. Thermal solar energy and biomass could provide most of the thermal energy required in the residential and commercial buildings and provide new solutions such as solar cooling, but people usually distrust because of its difficulties to be operated by no expert staff. In this situation remote operation systems are necessary to increase the number of installations and increase the sales. In the same way these kinds of systems could increase the technology exports to development countries where alternative energy sources can provide energy generation solutions that would improve the quality of life. (Author) 6 refs.

  12. The Utility of Cognitive Plausibility in Language Acquisition Modeling: Evidence from Word Segmentation

    Science.gov (United States)

    Phillips, Lawrence; Pearl, Lisa

    2015-01-01

    The informativity of a computational model of language acquisition is directly related to how closely it approximates the actual acquisition task, sometimes referred to as the model's "cognitive plausibility." We suggest that though every computational model necessarily idealizes the modeled task, an informative language acquisition…

  13. The Utility of Cognitive Plausibility in Language Acquisition Modeling: Evidence from Word Segmentation

    Science.gov (United States)

    Phillips, Lawrence; Pearl, Lisa

    2015-01-01

    The informativity of a computational model of language acquisition is directly related to how closely it approximates the actual acquisition task, sometimes referred to as the model's "cognitive plausibility." We suggest that though every computational model necessarily idealizes the modeled task, an informative language acquisition…

  14. “合情推理”辨析%Analysis of Plausible Reasoning

    Institute of Scientific and Technical Information of China (English)

    连四清; 方运加

    2012-01-01

    波利亚的“合情推理”模式引进我国数学课程标准后,就成了我国数学教育研究的关键词。然而,“合情推理”的科学性尚需考证:(1)它的中文意义不明确;(2)它不满足推理模式的客观性要求,存在明显的缺陷;(3)过分强调“合情推理模式”则是过分强调归纳推理和演绎推理的区别,容易割裂它们之间的关系。%After the model of "plausible inference" being introduced into the mathematics curriculum standards, it became a key word of the research on mathematics education in China. However, there are doubts on whether it is scientific. (1) Chinese meaning of plausible inference is ambiguous. (2) The plausible inference can not meet the objective requirement of the reasoning, which has obvious defects. (3) Overemphasizing the model of plausible inference would overemphasize the difference between deductive inference and inductive inference, and would dispart them.

  15. Alternative futures of dissolved inorganic nitrogen export from the Mississippi River Basin: influence of crop management, atmospheric deposition, and population growth

    Science.gov (United States)

    Nitrogen (N) export from the Mississippi River Basin contributes to seasonal hypoxia in the Gulf of Mexico (GOM). We explored monthly dissolved inorganic N (DIN) export to the GOM for a historical year (2002) and two future scenarios (year 2022) by linking macroeonomic energy, ag...

  16. From bone to plausible bipedal locomotion. Part II: Complete motion synthesis for bipedal primates.

    Science.gov (United States)

    Nicolas, Guillaume; Multon, Franck; Berillon, Gilles

    2009-05-29

    This paper addresses the problem of synthesizing plausible bipedal locomotion according to 3D anatomical reconstruction and general hypotheses on human motion control strategies. In a previous paper [Nicolas, G., Multon, F., Berillon, G., Marchal, F., 2007. From bone to plausible bipedal locomotion using inverse kinematics. Journal of Biomechanics 40 (5) 1048-1057], we have validated a method based on using inverse kinematics to obtain plausible lower-limb motions knowing the trajectory of the ankle. In this paper, we propose a more general approach that also involves computing a plausible trajectory of the ankles for a given skeleton. The inputs are the anatomical descriptions of the bipedal species, imposed footprints and a rest posture. This process is based on optimizing a reference ankle trajectory until a set of criteria is minimized. This optimization loop is based on the assumption that a plausible motion is supposed to have little internal mechanical work and should be as less jerky as possible. For each tested ankle trajectory, inverse kinematics is used to compute a lower-body motion that enables us to compute the resulting mechanical work and jerk. This method was tested on a set of modern humans (male and female, with various anthropometric properties). We show that the results obtained with this method are close to experimental data for most of the subjects. We also demonstrate that the method is not sensitive to the choice of the reference ankle trajectory; any ankle trajectory leads to very similar result. We finally apply the method to a skeleton of Pan paniscus (Bonobo), and compare the resulting motion to those described by zoologists.

  17. Some Aspects of Futurism

    Science.gov (United States)

    Sangchai, Samporn

    1975-01-01

    The article, an overview, surveys various schools of futures research with reference to futurism's dimensions (methodologies, typologies, and distance in time); planning for alternative futures; orientations; and inner-future orientations (mysticism vs. science). Developing nations are advised to adapt developed nations' learnings selectively, and…

  18. The Future of Futures

    DEFF Research Database (Denmark)

    Frankel, Christian; Ossandón, José

    2013-01-01

    Review of Elena Esposito: The Future of Futures. The Time of Money in Financing and Society Cheltenham. Edward Elgar, 2011.......Review of Elena Esposito: The Future of Futures. The Time of Money in Financing and Society Cheltenham. Edward Elgar, 2011....

  19. Alternative energies; Energies alternatives

    Energy Technology Data Exchange (ETDEWEB)

    Bonal, J.; Rossetti, P

    2007-07-01

    The earth took millions years to made the petroleum, the gas the coal and the uranium. Only a few centuries will be needed to exhaust these fossil fuels and some years to reach expensive prices. Will the wold continue on this way of energy compulsive consumption? The renewable energies and some citizen attitudes are sufficient to break this spiral. This book proposes to discuss these alternative energies. It shows that this attitude must be supported by the government. It takes stock on the more recent information concerning the renewable energies. it develops three main points: the electricity storage, the housing and the transports. (A.L.B.)

  20. Biologically plausible learning in recurrent neural networks reproduces neural dynamics observed during cognitive tasks.

    Science.gov (United States)

    Miconi, Thomas

    2017-02-23

    Neural activity during cognitive tasks exhibits complex dynamics that flexibly encode task-relevant variables. Chaotic recurrent networks, which spontaneously generate rich dynamics, have been proposed as a model of cortical computation during cognitive tasks. However, existing methods for training these networks are either biologically implausible, and/or require a continuous, real-time error signal to guide learning. Here we show that a biologically plausible learning rule can train such recurrent networks, guided solely by delayed, phasic rewards at the end of each trial. Networks endowed with this learning rule can successfully learn nontrivial tasks requiring flexible (context-dependent) associations, memory maintenance, nonlinear mixed selectivities, and coordination among multiple outputs. The resulting networks replicate complex dynamics previously observed in animal cortex, such as dynamic encoding of task features and selective integration of sensory inputs. We conclude that recurrent neural networks offer a plausible model of cortical dynamics during both learning and performance of flexible behavior.

  1. Identifying plausible genetic models based on association and linkage results: application to type 2 diabetes.

    Science.gov (United States)

    Guan, Weihua; Boehnke, Michael; Pluzhnikov, Anna; Cox, Nancy J; Scott, Laura J

    2012-12-01

    When planning resequencing studies for complex diseases, previous association and linkage studies can constrain the range of plausible genetic models for a given locus. Here, we explore the combinations of causal risk allele frequency (RAFC ) and genotype relative risk (GRRC ) consistent with no or limited evidence for affected sibling pair (ASP) linkage and strong evidence for case-control association. We find that significant evidence for case-control association combined with no or moderate evidence for ASP linkage can define a lower bound for the plausible RAFC . Using data from large type 2 diabetes (T2D) linkage and genome-wide association study meta-analyses, we find that under reasonable model assumptions, 23 of 36 autosomal T2D risk loci are unlikely to be due to causal variants with combined RAFC < 0.005, and four of the 23 are unlikely to be due to causal variants with combined RAFC < 0.05.

  2. Acquiring Plausible Predications from MEDLINE by Clustering MeSH Annotations.

    Science.gov (United States)

    Miñarro-Giménez, Jose Antonio; Kreuzthaler, Markus; Bernhardt-Melischnig, Johannes; Martínez-Costa, Catalina; Schulz, Stefan

    2015-01-01

    The massive accumulation of biomedical knowledge is reflected by the growth of the literature database MEDLINE with over 23 million bibliographic records. All records are manually indexed by MeSH descriptors, many of them refined by MeSH subheadings. We use subheading information to cluster types of MeSH descriptor co-occurrences in MEDLINE by processing co-occurrence information provided by the UMLS. The goal is to infer plausible predicates to each resulting cluster. In an initial experiment this was done by grouping disease-pharmacologic substance co-occurrences into six clusters. Then, a domain expert manually performed the assignment of meaningful predicates to the clusters. The mean accuracy of the best ten generated biomedical facts of each cluster was 85%. This result supports the evidence of the potential of MeSH subheadings for extracting plausible medical predications from MEDLINE.

  3. Spelling in oral deaf and hearing dyslexic children: A comparison of phonologically plausible errors.

    Science.gov (United States)

    Roy, P; Shergold, Z; Kyle, F E; Herman, R

    2014-11-01

    A written single word spelling to dictation test and a single word reading test were given to 68 severe-profoundly oral deaf 10-11-year-old children and 20 hearing children with a diagnosis of dyslexia. The literacy scores of the deaf children and the hearing children with dyslexia were lower than expected for children of their age and did not differ from each other. Three quarters of the spelling errors of hearing children with dyslexia compared with just over half the errors of the oral deaf group were phonologically plausible. Expressive vocabulary and speech intelligibility predicted the percentage of phonologically plausible errors in the deaf group only. Implications of findings for the phonological decoding self-teaching model and for supporting literacy development are discussed.

  4. Of paradox and plausibility: the dynamic of change in medical law.

    Science.gov (United States)

    Harrington, John

    2014-01-01

    This article develops a model of change in medical law. Drawing on systems theory, it argues that medical law participates in a dynamic of 'deparadoxification' and 'reparadoxification' whereby the underlying contingency of the law is variously concealed through plausible argumentation, or revealed by critical challenge. Medical law is, thus, thoroughly rhetorical. An examination of the development of the law on abortion and on the sterilization of incompetent adults shows that plausibility is achieved through the deployment of substantive common sense and formal stylistic devices. It is undermined where these elements are shown to be arbitrary and constructed. In conclusion, it is argued that the politics of medical law are constituted by this antagonistic process of establishing and challenging provisionally stable normative regimes.

  5. Alternative additives; Alternative additiver

    Energy Technology Data Exchange (ETDEWEB)

    2007-08-15

    In this project a number of industrial and agricultural waste products have been characterised and evaluated in terms of alkali-getter performance. The intended use is for biomass-fired power stations aiming at reducing corrosion or slagging related problems. The following products have been obtained, characterised and evaluated: 1) Brewery draff 2) Danish de-gassed manure 3) Paper sludge 4) Moulding sand 5) Spent bleaching earth 6) Anorthosite 7) Sand 8) Clay-sludge. Most of the above alternative additive candidates are deemed unsuitable due to insufficient chemical effect and/or expensive requirements for pre-treatment (such as drying and transportation). 3 products were selected for full-scale testing: de-gassed manure, spent bleaching earth and clay slugde. The full scale tests were undertaken at the biomass-fired power stations in Koege, Slagelse and Ensted. Spent bleaching earth (SBE) and clay sludge were the only tested additive candidates that had a proven ability to react with KCl, to thereby reduce Cl-concentrations in deposits, and reduce the deposit flux to superheater tubes. Their performance was shown to nearly as good as commercial additives. De-gassed manure, however, did not evaluate positively due to inhibiting effects of Ca in the manure. Furthermore, de-gassed manure has a high concentration of heavy metals, which imposes a financial burden with regard to proper disposal of the ash by-products. Clay-sludge is a wet clay slurring, and drying and transportation of this product entails substantial costs. Spent bleaching does not require much pre-treatment and is therefore the most promising alternative additive. On the other hand, bleaching earth contains residual plant oil which means that a range of legislation relating to waste combustion comes into play. Not least a waste combustion fee of 330 DKK/tonne. For all alternative (and commercial) additives disposal costs of the increase ash by-products represents a significant cost. This is

  6. For New Zealand -- Natural gas is a plausible introduction to biomass energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Jawetz, P.

    1983-12-01

    The approach suggested here leads to the future introduction of methanol, ethanol and fuel gases, produced from a long list of other sources, i.e., biomass, coal, peat, as well as from rather new natural gas sources. As a first step in this direction, using methanol as an octane boosting additive to gasoline at the refinery allows for the use of an unchanged refinery, thus saving on capital investments and on crude while leading to an eventual future that may eliminate reliance on the refinery altogether. The real issue here is what makes more sense -- (A) to attempt to provide synthetic fuels to existing energy systems, or (B) to use an interim fuel easily available in New Zealand in order to change the energy system so that the dependence on petroleum is broken. For the case of New Zealand -- a set of two islands without cross traffic -- it can be proven easily that changing the energy system is not going to create an impossible burden. Specifically: the proposed Motunui plant that was planned to use natural gas to produce synthetic gasoline is a US $2 billion project. It leaves New Zealand hopelessly dependent on imported crude for diesel and requires a further US $1 billion investment in the local refinery, thus in effect increasing the national debt per capita by a further US $1,000. These funds could have been used instead to promote the proposed alternative route -- the route that would have changed a large part of the motor vehicle fleet from gasoline and diesel fuel to CNG and methanol fuel. Such a solution, if proven in New Zealand, could then be attempted in other countries that have medium-size natural gas resources and a larger potential of future biomass fuel resources that could then be developed at an acceptable pace without causing any foodversus-fuel competition or unwanted social effects.

  7. On the plausible association between environmental conditions and human eye damage.

    Science.gov (United States)

    Feretis, Elias; Theodorakopoulos, Panagiotis; Varotsos, Costas; Efstathiou, Maria; Tzanis, Christos; Xirou, Tzina; Alexandridou, Nancy; Aggelou, Michael

    2002-01-01

    The increase in solar ultraviolet radiation can have various direct and indirect effects on human health, like the incidence of ocular damage. Data of eye damage in residents of three suburban regions in Greece and in two groups of monks/nuns and fishermen are examined here. The statistics performed on these data provides new information about the plausible association between increased levels of solar ultraviolet radiation, air-pollution at ground level, and the development of ocular defects.

  8. A biologically plausible model of time-scale invariant interval timing.

    Science.gov (United States)

    Almeida, Rita; Ledberg, Anders

    2010-02-01

    The temporal durations between events often exert a strong influence over behavior. The details of this influence have been extensively characterized in behavioral experiments in different animal species. A remarkable feature of the data collected in these experiments is that they are often time-scale invariant. This means that response measurements obtained under intervals of different durations coincide when plotted as functions of relative time. Here we describe a biologically plausible model of an interval timing device and show that it is consistent with time-scale invariant behavior over a substantial range of interval durations. The model consists of a set of bistable units that switch from one state to the other at random times. We first use an abstract formulation of the model to derive exact expressions for some key quantities and to demonstrate time-scale invariance for any range of interval durations. We then show how the model could be implemented in the nervous system through a generic and biologically plausible mechanism. In particular, we show that any system that can display noise-driven transitions from one stable state to another can be used to implement the timing device. Our work demonstrates that a biologically plausible model can qualitatively account for a large body of data and thus provides a link between the biology and behavior of interval timing.

  9. An integrated framework to assess plausible future livelihood and poverty changes in deltas: an application to coastal Bangladesh

    Science.gov (United States)

    Lázár, A. N.; Payo, A.; Nicholls, R. J.; Hutton, C.; Adams, H.; Salehin, M.; Haque, A.; Clarke, D.; Bricheno, L.; Fernandes, J. A.; Rahman, M.; Ahmed, A.; Streatfield, P. K.

    2015-12-01

    Deltas represent one of the most densely populated areas in the world. This is especially true for the coastal zone of Bangladesh where more than a thousand people live in each square kilometre of land. Livelihoods, food security and poverty in Bangladesh are strongly dependent on natural resources affected by several factors including climate variability and change, upstream river flow modifications, commercial fish catches in the Bay of Bengal, and engineering interventions such as polderisation. The scarcity of fresh water, saline water intrusion and natural disasters (e.g. river flooding, cyclones and storm surges) have negative impact on drinking water availability and crop irrigation potential; thus severely affect land use and livelihood opportunities of the coastal population. Hydro-environmental changes can be especially detrimental for the well-being of the poorest households that are highly dependent on natural resources. The ESPA Deltas project aims to holistically examine the interaction between the coupled bio-physical environment and the livelihoods of these poor populations in coastal Bangladesh. Here we describe a new integrated model that allows the long-term analysis of the possible changes in this system by linking projected changes in physical processes (e.g. river flows, nutrients), with productivity (e.g. fish, rice), social processes (e.g. access, property rights, migration) and governance/management (e.g. fisheries, agriculture, water and land use management). This integrated approach is designed to provide Bangladeshi policy makers with science-based evidence of possible development trajectories within the coastal delta plain over timescales up to 50 years, including the likely robustness of different governance options on natural resource conservation and poverty levels. This presentation describes the model framework and aims to illustrate the cause-effect relationship in-between changes of the hydro-environment and the livelihoods and poverty of the coastal population of Bangladesh.

  10. Geopolitical Trends and Security Challenges across the Indian Ocean and Asia-Pacific Regions; Strategic Insights, v. 10, Special issue (October 2011), 28-35. Topic: Global Trends and Future Warfare ; Part I: Alternative Perspectives: Traditional Powers, Rising Powers, and the Developing World

    OpenAIRE

    Parthasarathy, G.

    2011-01-01

    This article appeared in Strategic Insights, v.10, Special issue (October 2011), 28-35. Topic: Global Trends and Future Warfare ; Part I: Alternative Perspectives: Traditional Powers, Rising Powers, and the Developing World Approved for public display, distribution unlimited

  11. An expert consortium review of the EC-commissioned report "alternative (Non-Animal) methods for cosmetics testing: current status and future prospects - 2010".

    Science.gov (United States)

    Hartung, Thomas; Blaauboer, Bas J; Bosgra, Sieto; Carney, Edward; Coenen, Joachim; Conolly, Rory B; Corsini, Emanuela; Green, Sidney; Faustman, Elaine M; Gaspari, Anthony; Hayashi, Makoto; Wallace Hayes, A; Hengstler, Jan G; Knudsen, Lisbeth E; Knudsen, Thomas B; McKim, James M; Pfaller, Walter; Roggen, Erwin L

    2011-01-01

    The European cosmetics legislation foresees a review in 2011 and possible postponement of the 2013 marketing ban to enforce the testing ban for systemic and repeated-dose animal tests. For this purpose, a 119-page report commissioned by the European Commission was published recently. Here, a group of 17 independent experts from the US, Europe, and Japan was brought together to evaluate the report. The expert panel strongly endorsed the report and its conclusions. A number of important options not considered were identified; these do not, however, affect the overall conclusions regarding the current lack of availability of a full replacement, especially for the areas of repeated dose toxicity, carcinogenicity testing, and reproductive toxicity, though a roadmap for change is emerging. However, some of these options may provide adequate data for replacement of some animal studies in the near future pending validation. Various recommendations expand the original report. The reviewers agree with the report that there is greater promise in the short term for the areas of sensitization and toxicokinetics. Additional opportunities lie in more global collaborations and the inclusion of other industry sectors.

  12. Phase II - final report study of alternatives for future operations of the naval petroleum and oil shale reserves NOSR 1 & 3, Colorado

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-01

    The US Department of Energy (DOE) has asked Gustavson Associates, Inc. to serve as an Independent Petroleum Consultant under contract DE-AC01-96FE64202. This authorizes a study and recommendations regarding future development of Naval Petroleum Oil Shales Reserves Nos. 1 and 3 (NOSR 1 and 3) in Garfield County, Colorado (Figure 0.1). The report that follows is the Phase II Final Report for that study. Additional details are provided in the Addendum (the Phase 1 Property Description and Fact Finding Report). The key property elements that positively affect the estimated value of NOSR 1 and 3 include the following: working interest income from producing oil and gas leases, income from grazing or leasing of grazing rights, potential income from oil and gas leasing on exploratory (or nonprospective) acreage, potential value of trading surface real estate as ranch land for livestock grazing (56,577 acres). Key elements that negatively impact the estimated value include: environmental assessment costs, gas prices, operating budgets, and lease sale expenses.

  13. Study of alternatives for future operations of the naval petroleum and oil shale reserves, NOSR-2, Uintah and Carbon Counties, Utah. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-01

    The US Department of Energy (DOE) has asked Gustavson Associates, Inc. to serve as an Independent Petroleum Consultant and authorized a study and recommendations regarding future development of Naval Oil Shale Reserve No. 2 (NOSR-2) in Uintah and Carbon Counties, Utah. The US owns 100% of the mineral rights and about 60% of the surface rights in NOSR-2. The Ute Indian Tribe owns the other 40% of the surface. This 88,890-acre tract was set aside as an oil shale reserve for the US Navy by an Executive Order of President Wilson in 1916. Management of NOSR-2 is the responsibility of DOE. No drilling for oil and gas has occurred on the property and no production has been established. No reserves are present, although the area is hypothesized to overlay gas resources. Mapping by the US Geological Survey and others has resulted in speculative seismic leads for structures that may or may not hold conventional oil and gas. All of the mineral rights (including oil shale) must be considered exploratory and the mineral rights must be valued accordingly. The opinion recommended to maximize value to the US is Option 4, sale of the interest of the US of all or part of NOSR-2. Evaluation of this option results in an estimated value which is more than three times greater than the next highest estimated value, for Option 2, transfer to the Department of the Interior for leasing.

  14. Phase II - final report study of alternatives for future operations of the naval petroleum and oil shale reserves NOSR 1 & 3, Colorado

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-12-01

    The US Department of Energy (DOE) has asked Gustavson Associates, Inc. to serve as an Independent Petroleum Consultant under contract DE-AC01-96FE64202. This authorizes a study and recommendations regarding future development of Naval Petroleum Oil Shales Reserves Nos. 1 and 3 (NOSR 1 and 3) in Garfield County, Colorado (Figure 0.1). The report that follows is the Phase II Final Report for that study. Additional details are provided in the Addendum (the Phase 1 Property Description and Fact Finding Report). The key property elements that positively affect the estimated value of NOSR 1 and 3 include the following: working interest income from producing oil and gas leases, income from grazing or leasing of grazing rights, potential income from oil and gas leasing on exploratory (or nonprospective) acreage, potential value of trading surface real estate as ranch land for livestock grazing (56,577 acres). Key elements that negatively impact the estimated value include: environmental assessment costs, gas prices, operating budgets, and lease sale expenses.

  15. The role of natural gas as a primary fuel in the near future, including comparisons of acquisition, transmission and waste handling costs of as with competitive alternatives.

    Science.gov (United States)

    Liang, Fang-Yu; Ryvak, Marta; Sayeed, Sara; Zhao, Nick

    2012-04-23

    Natural gas comprises about a quarter of the United States' energy use. It is more environmentally friendly than oil and coal due to lower carbon dioxide (CO2) emissions per unit, less costly per unit of energy and more readily available domestically in abundant supply. However, due to a number of barriers in the political, infrastructural, pricing and other arenas, the use of natural gas as a significant energy source in the United States has been limited. In our paper, we highlight the favorable qualities of natural gas and its benefits for the consumer, producer, and environment, having compared the costs of the various components of the natural gas business such as drilling and transport to that of coal and oil. Moreover, we touch upon the major issues that have prevented a more prevalent use of the gas, such as the fact that the infrastructure of natural gas is more costly since it is transported though pipelines whereas other energy sources such as oil and coal have flexible systems that use trains, trucks and ships. In addition, the powerful lobbies of the coal and oil businesses, along with the inertia in the congress to pass a national climate change bill further dampens incentives for these industries to invest in natural gas, despite its various attractive qualities. We also include discussions of policy proposals to incentive greater use of natural gas in the future.

  16. The Future Multiple

    DEFF Research Database (Denmark)

    Spaniol, Matthew Jon; Rowland, Nicholas James

    2015-01-01

    , if “the future” were so preposterous an idea, then “futures” would cease to be a critical alternative to it. Futures needs the future; they are relationally bound together in a multiplicity. This paper considers what such a logical reality implies for a field that distances itself from the future and self...

  17. Understanding Karma Police: The Perceived Plausibility of Noun Compounds as Predicted by Distributional Models of Semantic Representation

    Science.gov (United States)

    Günther, Fritz; Marelli, Marco

    2016-01-01

    Noun compounds, consisting of two nouns (the head and the modifier) that are combined into a single concept, differ in terms of their plausibility: school bus is a more plausible compound than saddle olive. The present study investigates which factors influence the plausibility of attested and novel noun compounds. Distributional Semantic Models (DSMs) are used to obtain formal (vector) representations of word meanings, and compositional methods in DSMs are employed to obtain such representations for noun compounds. From these representations, different plausibility measures are computed. Three of those measures contribute in predicting the plausibility of noun compounds: The relatedness between the meaning of the head noun and the compound (Head Proximity), the relatedness between the meaning of modifier noun and the compound (Modifier Proximity), and the similarity between the head noun and the modifier noun (Constituent Similarity). We find non-linear interactions between Head Proximity and Modifier Proximity, as well as between Modifier Proximity and Constituent Similarity. Furthermore, Constituent Similarity interacts non-linearly with the familiarity with the compound. These results suggest that a compound is perceived as more plausible if it can be categorized as an instance of the category denoted by the head noun, if the contribution of the modifier to the compound meaning is clear but not redundant, and if the constituents are sufficiently similar in cases where this contribution is not clear. Furthermore, compounds are perceived to be more plausible if they are more familiar, but mostly for cases where the relation between the constituents is less clear. PMID:27732599

  18. Alternative Medicine

    Science.gov (United States)

    ... Involved News About Us Donate In This Section Alternative Medicine en Español email Send this article to a ... Dr. Yvonne Ou on Lifestyle Modifications and Glaucoma Alternative medicine may be defined as non-standard, unconventional treatments ...

  19. A Novel Discovery of Growth Process for Ag Nanowires and Plausible Mechanism

    Directory of Open Access Journals (Sweden)

    Jiejun Zhu

    2016-01-01

    Full Text Available A novel growth process of silver nanowires was revealed by tracing the morphology evolution of Ag nanostructures fabricated by an improved polyol process. A mixture of Ag nanowires and nanoparticles was obtained with the usage of PVP-K25 (MW = 38,000. The products sampled at different reaction time were studied in detail using UV-visible absorption spectra and transmission electron microscopy (TEM. An interesting phenomenon unknown in the past was observed where Ag nanoparticles undergo an important dissolution-recrystallization process and Ag nanowires are formed at the expense of the preformed Ag nanoparticles. A plausible novel growth mechanism for the silver nanowires was proposed.

  20. A biological plausible Generalized Leaky Integrate-and-Fire neuron model.

    Science.gov (United States)

    Wang, Zhenzhong; Guo, Lilin; Adjouadi, Malek

    2014-01-01

    This study introduces a new Generalized Leaky Integrate-and-Fire (GLIF) neuron model. Unlike Normal Leaky Integrate-and-Fire (NLIF) models, the leaking resistor in the GLIF model equation is assumed to be variable, and an additional term would have the bias current added to the model equation in order to improve the accuracy. Adjusting the parameters defined for the leaking resistor and bias current, a GLIF model could be accurately matched to any Hodgkin-Huxley (HH) model and be able to reproduce plausible biological neuron behaviors.

  1. Higher Data Quality by Online Data-Entry and Automated Plausibility Checks

    Science.gov (United States)

    Pietragalla, Barbara; Sigg, Christian; Güsewell, Sabine; Clot, Bernard

    2014-05-01

    Long-term phenological observations are now recognized as important indicators for climate change impact studies. With the increased need for phenological data, there is also an increased need for higher data quality. Since 1951 MeteoSwiss has been operating a national phenological observation network. Currently the network consists of about 150 active stations observing up to 69 different phenophases. An important aim of a running three years project at MeteoSwiss is a further increase of the quality of the collected data. The higher data quality will be achieved by an automated procedure performing plausibility checks on the data and by online data-entry. Further measures such as intensified observer instructions and collection of more detailed metadata also contribute to a high data quality standard. The plausibility checks include the natural order of the phenophases within a species and also between different species (with regard to possible natural deviation). Additionally it will be checked if the observed date differs by less than two standard deviations from the average for this phenophase at the altitude of the station. A value outside of these limits is not necessarily a false value, since occurrences of extreme values will be beyond these limits. Therefore, within this check of the limits, the timing of the season of the respective year will also be taken into account. In case of an implausible value a comparison with other stations of the same region and sea level is proposed. A further possibility of data quality control could be to model the different phenophases statistically and to use this model for estimating the likelihood of observed values. An overall exploratory data analysis is currently performed providing a solid basis to implement the best possible methods for the plausibility checks. Important advantages of online data-entry are the near real-time availability of the data as well as the avoidance of various kinds of typical mistakes

  2. Exploring discrepancies between quantitative validation results and the geomorphic plausibility of statistical landslide susceptibility maps

    Science.gov (United States)

    Steger, Stefan; Brenning, Alexander; Bell, Rainer; Petschko, Helene; Glade, Thomas

    2016-06-01

    Empirical models are frequently applied to produce landslide susceptibility maps for large areas. Subsequent quantitative validation results are routinely used as the primary criteria to infer the validity and applicability of the final maps or to select one of several models. This study hypothesizes that such direct deductions can be misleading. The main objective was to explore discrepancies between the predictive performance of a landslide susceptibility model and the geomorphic plausibility of subsequent landslide susceptibility maps while a particular emphasis was placed on the influence of incomplete landslide inventories on modelling and validation results. The study was conducted within the Flysch Zone of Lower Austria (1,354 km2) which is known to be highly susceptible to landslides of the slide-type movement. Sixteen susceptibility models were generated by applying two statistical classifiers (logistic regression and generalized additive model) and two machine learning techniques (random forest and support vector machine) separately for two landslide inventories of differing completeness and two predictor sets. The results were validated quantitatively by estimating the area under the receiver operating characteristic curve (AUROC) with single holdout and spatial cross-validation technique. The heuristic evaluation of the geomorphic plausibility of the final results was supported by findings of an exploratory data analysis, an estimation of odds ratios and an evaluation of the spatial structure of the final maps. The results showed that maps generated by different inventories, classifiers and predictors appeared differently while holdout validation revealed similar high predictive performances. Spatial cross-validation proved useful to expose spatially varying inconsistencies of the modelling results while additionally providing evidence for slightly overfitted machine learning-based models. However, the highest predictive performances were obtained for

  3. A biologically plausible transform for visual recognition that is invariant to translation, scale and rotation

    Directory of Open Access Journals (Sweden)

    Pavel eSountsov

    2011-11-01

    Full Text Available Visual object recognition occurs easily despite differences in position, size, and rotation of the object, but the neural mechanisms responsible for this invariance are not known. We have found a set of transforms that achieve invariance in a neurally plausible way. We find that a transform based on local spatial frequency analysis of oriented segments and on logarithmic mapping, when applied twice in an iterative fashion, produces an output image that is unique to the object and that remains constant as the input image is shifted, scaled or rotated.

  4. Self-assembly of phosphate amphiphiles in mixtures of prebiotically plausible surfactants.

    Science.gov (United States)

    Albertsen, A N; Duffy, C D; Sutherland, J D; Monnard, P-A

    2014-06-01

    The spontaneous formation of closed bilayer structures from prebiotically plausible amphiphiles is an essential requirement for the emergence of early cells on prebiotic Earth. The sources of amphiphiles could have been both endo- and exogenous (accretion of meteorite carbonaceous material or interstellar dust particles). Among all prebiotic possible amphiphile candidates, those containing phosphate are the least investigated species because their self-assembly occurs in a seemingly too narrow range of conditions. The self-assembly of simple phosphate amphiphiles should, however, be of great interest, as contemporary membranes predominantly contain phospholipids. In contrast to common expectations, we show that these amphiphiles can be easily synthesized under prebiotically plausible environmental conditions and can efficiently form bilayer structures in the presence of various co-surfactants across a large range of pH values. Vesiculation was even observed in crude reaction mixtures that contained 1-decanol as the amphiphile precursor. The two best co-surfactants promoted vesicle formation over the entire pH range in aqueous solutions. Expanding the pH range where bilayer membranes self-assemble and remain intact is a prerequisite for the emergence of early cell-like compartments and their preservation under fluctuating environmental conditions. These mixed bilayers also retained small charged solutes, such as dyes. These results demonstrate that alkyl phosphate amphiphiles might have played a significant role as early compartment building blocks.

  5. A swarm intelligence framework for reconstructing gene networks: searching for biologically plausible architectures.

    Science.gov (United States)

    Kentzoglanakis, Kyriakos; Poole, Matthew

    2012-01-01

    In this paper, we investigate the problem of reverse engineering the topology of gene regulatory networks from temporal gene expression data. We adopt a computational intelligence approach comprising swarm intelligence techniques, namely particle swarm optimization (PSO) and ant colony optimization (ACO). In addition, the recurrent neural network (RNN) formalism is employed for modeling the dynamical behavior of gene regulatory systems. More specifically, ACO is used for searching the discrete space of network architectures and PSO for searching the corresponding continuous space of RNN model parameters. We propose a novel solution construction process in the context of ACO for generating biologically plausible candidate architectures. The objective is to concentrate the search effort into areas of the structure space that contain architectures which are feasible in terms of their topological resemblance to real-world networks. The proposed framework is initially applied to the reconstruction of a small artificial network that has previously been studied in the context of gene network reverse engineering. Subsequently, we consider an artificial data set with added noise for reconstructing a subnetwork of the genetic interaction network of S. cerevisiae (yeast). Finally, the framework is applied to a real-world data set for reverse engineering the SOS response system of the bacterium Escherichia coli. Results demonstrate the relative advantage of utilizing problem-specific knowledge regarding biologically plausible structural properties of gene networks over conducting a problem-agnostic search in the vast space of network architectures.

  6. The Sarrazin effect: the presence of absurd statements in conspiracy theories makes canonical information less plausible.

    Science.gov (United States)

    Raab, Marius Hans; Auer, Nikolas; Ortlieb, Stefan A; Carbon, Claus-Christian

    2013-01-01

    Reptile prime ministers and flying Nazi saucers-extreme and sometimes off-wall conclusion are typical ingredients of conspiracy theories. While individual differences are a common research topic concerning conspiracy theories, the role of extreme statements in the process of acquiring and passing on conspiratorial stories has not been regarded in an experimental design so far. We identified six morphological components of conspiracy theories empirically. On the basis of these content categories a set of narrative elements for a 9/11 story was compiled. These elements varied systematically in terms of conspiratorial allegation, i.e., they contained official statements concerning the events of 9/11, statements alleging to a conspiracy limited in time and space as well as extreme statements indicating an all-encompassing cover-up. Using the method of narrative construction, 30 people were given a set of cards with these statements and asked to construct the course of events of 9/11 they deem most plausible. When extreme statements were present in the set, the resulting stories were more conspiratorial; the number of official statements included in the narrative dropped significantly, whereas the self-assessment of the story's plausibility did not differ between conditions. This indicates that blatant statements in a pool of information foster the synthesis of conspiracy theories on an individual level. By relating these findings to one of Germany's most successful (and controversial) non-fiction books, we refer to the real-world dangers of this effect.

  7. Testing the physiological plausibility of conflicting psychological models of response inhibition: A forward inference fMRI study.

    Science.gov (United States)

    Criaud, Marion; Longcamp, Marieke; Anton, Jean-Luc; Nazarian, Bruno; Roth, Muriel; Sescousse, Guillaume; Strafella, Antonio P; Ballanger, Bénédicte; Boulinguez, Philippe

    2017-08-30

    The neural mechanisms underlying response inhibition and related disorders are unclear and controversial for several reasons. First, it is a major challenge to assess the psychological bases of behaviour, and ultimately brain-behaviour relationships, of a function which is precisely intended to suppress overt measurable behaviours. Second, response inhibition is difficult to disentangle from other parallel processes involved in more general aspects of cognitive control. Consequently, different psychological and anatomo-functional models coexist, which often appear in conflict with each other even though they are not necessarily mutually exclusive. The standard model of response inhibition in go/no-go tasks assumes that inhibitory processes are reactively and selectively triggered by the stimulus that participants must refrain from reacting to. Recent alternative models suggest that action restraint could instead rely on reactive but non-selective mechanisms (all automatic responses are automatically inhibited in uncertain contexts) or on proactive and non-selective mechanisms (a gating function by which reaction to any stimulus is prevented in anticipation of stimulation when the situation is unpredictable). Here, we assessed the physiological plausibility of these different models by testing their respective predictions regarding event-related BOLD modulations (forward inference using fMRI). We set up a single fMRI design which allowed for us to record simultaneously the different possible forms of inhibition while limiting confounds between response inhibition and parallel cognitive processes. We found BOLD dynamics consistent with non-selective models. These results provide new theoretical and methodological lines of inquiry for the study of basic functions involved in behavioural control and related disorders. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. Alternative Future Fleet Platform Architecture Study

    Science.gov (United States)

    2016-10-27

    1067 of the National Defense Authorization Act for Fiscal Year 2016 (Appendix 1) directed the Secretary of Defense to conduct three independent studies... Secretary of Defense, the Naval Surface Warfare Center, Dahlgren Division, the Naval Postgraduate School, the U.S. Naval War College, the Center for...this leadership role , the Navy Project Team identified the key missions for the U.S. Navy: - protecting the homeland - building security globally

  9. Future Fossil Fuel Alternative; DME (A review)

    OpenAIRE

    Erdener, Hülya; Arinan, Ayca; Orman, Sultan

    2016-01-01

    The world energy consumption is steadily growing with the industrial improvements of the developing countries and the readily available fossil fuel reserves lack in fulfilling this energy requirement. The depletion of the easily achievable reserves; gives rise to the concept of oil production from oil shale and tar sands. However, the high cost and the operational difficulties stand as the major drawbacks in front of these technologies. Along with these circumstances, and the environmental co...

  10. Experimenting with Alternative Futures in Cairo

    DEFF Research Database (Denmark)

    Sparre, Sara Cathrine Lei

    2017-01-01

    . Focusing mainly on two young volunteers, I show how their Resala experiences within specific socio-political circumstances paved the way for personal hopes to develop into utopian aspirations. Demonstrating the dynamic relationship between the formation of political subjectivities and how utopias emerge......This article investigates young, middle-class Egyptians’ engagement with the religious and national visions of Resala, Egypt’s largest Muslim youth NGO, and how they come to rethink themselves existentially and politically through this commitment and with the 2011 uprising and its aftermath...

  11. Future alternative therapies for β-thalassemia.

    Science.gov (United States)

    Rivella, Stefano; Rachmilewitz, Eliezer

    2009-12-01

    β-thalassemia is an inherited disorder due to mutations found in the β-globin gene, leading to anemia and requiring sporadic or chronic blood transfusions for survival. Without proper chelation, β-thalassemia results in iron overload. Ineffective erythropoiesis can lead to iron overload even in untransfused patients who are affected by β-thalassemia intermedia. Better understanding of the molecular biologic aspects of this disorder has led to improvements in population screening and prenatal diagnosis, which, in turn, have led to dramatic reductions in the number of children born with β-thalassemia major in the Mediterranean littoral. However, as a consequence of decreases in neonatal and childhood mortality in other geographical areas, β-thalassemia has become a worldwide clinical problem. A number of unsolved pathophysiological issues remain, such as ineffective erythropoieis, abnormal iron absorption, oxidative stress, splenomegaly and thrombosis. In the last few years, novel studies have the potential to introduce new therapeutic approaches that might reduce these problems and limit the need for blood transfusion.

  12. Future alternatives to GSM-R

    DEFF Research Database (Denmark)

    Sniady, Aleksander; Soler, José; Dittmann, Lars

    Signalling is as fundamental contributor to a robust railway system. European Railway Traffic Management System (ERTMS) enhances dynamic train control, interoperability and track utilization. GSM-R is a communication subsystem in ERTMS.......Signalling is as fundamental contributor to a robust railway system. European Railway Traffic Management System (ERTMS) enhances dynamic train control, interoperability and track utilization. GSM-R is a communication subsystem in ERTMS....

  13. A neurophysiologically plausible population code model for feature integration explains visual crowding.

    Directory of Open Access Journals (Sweden)

    Ronald van den Berg

    2010-01-01

    Full Text Available An object in the peripheral visual field is more difficult to recognize when surrounded by other objects. This phenomenon is called "crowding". Crowding places a fundamental constraint on human vision that limits performance on numerous tasks. It has been suggested that crowding results from spatial feature integration necessary for object recognition. However, in the absence of convincing models, this theory has remained controversial. Here, we present a quantitative and physiologically plausible model for spatial integration of orientation signals, based on the principles of population coding. Using simulations, we demonstrate that this model coherently accounts for fundamental properties of crowding, including critical spacing, "compulsory averaging", and a foveal-peripheral anisotropy. Moreover, we show that the model predicts increased responses to correlated visual stimuli. Altogether, these results suggest that crowding has little immediate bearing on object recognition but is a by-product of a general, elementary integration mechanism in early vision aimed at improving signal quality.

  14. A neurophysiologically plausible population code model for feature integration explains visual crowding.

    Science.gov (United States)

    van den Berg, Ronald; Roerdink, Jos B T M; Cornelissen, Frans W

    2010-01-22

    An object in the peripheral visual field is more difficult to recognize when surrounded by other objects. This phenomenon is called "crowding". Crowding places a fundamental constraint on human vision that limits performance on numerous tasks. It has been suggested that crowding results from spatial feature integration necessary for object recognition. However, in the absence of convincing models, this theory has remained controversial. Here, we present a quantitative and physiologically plausible model for spatial integration of orientation signals, based on the principles of population coding. Using simulations, we demonstrate that this model coherently accounts for fundamental properties of crowding, including critical spacing, "compulsory averaging", and a foveal-peripheral anisotropy. Moreover, we show that the model predicts increased responses to correlated visual stimuli. Altogether, these results suggest that crowding has little immediate bearing on object recognition but is a by-product of a general, elementary integration mechanism in early vision aimed at improving signal quality.

  15. Quantum theory as plausible reasoning applied to data obtained by robust experiments.

    Science.gov (United States)

    De Raedt, H; Katsnelson, M I; Michielsen, K

    2016-05-28

    We review recent work that employs the framework of logical inference to establish a bridge between data gathered through experiments and their objective description in terms of human-made concepts. It is shown that logical inference applied to experiments for which the observed events are independent and for which the frequency distribution of these events is robust with respect to small changes of the conditions under which the experiments are carried out yields, without introducing any concept of quantum theory, the quantum theoretical description in terms of the Schrödinger or the Pauli equation, the Stern-Gerlach or Einstein-Podolsky-Rosen-Bohm experiments. The extraordinary descriptive power of quantum theory then follows from the fact that it is plausible reasoning, that is common sense, applied to reproducible and robust experimental data.

  16. Plausible families of compact objects with a Non Local Equation of State

    CERN Document Server

    Hernández, H

    2012-01-01

    We investigate the plausibility of some models emerging from an algorithm devised to generate a one-parameter family of interior solutions for the Einstein equations. It is explored how their physical variables change as the family-parameter varies. The models studied correspond to anisotropic spherical matter configurations having a non local equation of state. This particular type of equation of state with no causality problems provides, at a given point, the radial pressure not only as a function of the density but as a functional of the enclosed matter distribution. We have found that there are several model-independent tendencies as the parameter increases: the equation of state tends to be stiffer and the total mass becomes half of its external radius. Profiting from the concept of cracking of materials in General Relativity, we obtain that those models become more stable as the family parameter increases.

  17. Signature of Plausible Accreting Supermassive Black Holes in Mrk 261/262 and Mrk 266

    Directory of Open Access Journals (Sweden)

    Gagik Ter-Kazarian

    2013-01-01

    Full Text Available We address the neutrino radiation of plausible accreting supermassive black holes closely linking to the 5 nuclear components of galaxy samples of Mrk 261/262 and Mrk 266. We predict a time delay before neutrino emission of the same scale as the age of the Universe. The ultrahigh energy neutrinos are produced in superdense protomatter medium via simple (quark or pionic reactions or modified URCA processes (G. Gamow was inspired to name the process URCA after the name of a casino in Rio de Janeiro. The resulting neutrino fluxes for quark reactions are ranging from to , where is the opening parameter. For pionic and modified URCA reactions, the fluxes are and , respectively. These fluxes are highly beamed along the plane of accretion disk, peaked at ultrahigh energies, and collimated in smaller opening angle .

  18. Plausible role of nanoparticle contamination in the synthesis and properties of organic electronic materials

    Science.gov (United States)

    Ananikov, Valentine P.

    2016-12-01

    Traceless transition metal catalysis (Pd, Ni, Cu, etc.) is very difficult to achieve. Metal contamination in the synthesized products is unavoidable and the most important questions are: How to control metal impurities? What amount of metal impurities can be tolerated? What is the influence of metal impurities? In this brief review, the plausible origins of nanoparticle contamination are discussed in the framework of catalytic synthesis of organic electronic materials. Key factors responsible for increasing the probability of contamination are considered from the point of view of catalytic reaction mechanisms. The purity of the catalyst may greatly affect the molecular weight of a polymer, reaction yield, selectivity and several other parameters. Metal contamination in the final polymeric products may induce some changes in the electric conductivity, charge transport properties, photovoltaic performance and other important parameters.

  19. Spontaneous formation and base pairing of plausible prebiotic nucleotides in water.

    Science.gov (United States)

    Cafferty, Brian J; Fialho, David M; Khanam, Jaheda; Krishnamurthy, Ramanarayanan; Hud, Nicholas V

    2016-04-25

    The RNA World hypothesis presupposes that abiotic reactions originally produced nucleotides, the monomers of RNA and universal constituents of metabolism. However, compatible prebiotic reactions for the synthesis of complementary (that is, base pairing) nucleotides and mechanisms for their mutual selection within a complex chemical environment have not been reported. Here we show that two plausible prebiotic heterocycles, melamine and barbituric acid, form glycosidic linkages with ribose and ribose-5-phosphate in water to produce nucleosides and nucleotides in good yields. Even without purification, these nucleotides base pair in aqueous solution to create linear supramolecular assemblies containing thousands of ordered nucleotides. Nucleotide anomerization and supramolecular assemblies favour the biologically relevant β-anomer form of these ribonucleotides, revealing abiotic mechanisms by which nucleotide structure and configuration could have been originally favoured. These findings indicate that nucleotide formation and selection may have been robust processes on the prebiotic Earth, if other nucleobases preceded those of extant life.

  20. Complex adaptive HIV/AIDS risk reduction: Plausible implications from findings in Limpopo Province, South Africa.

    Science.gov (United States)

    Burman, Chris J; Aphane, Marota A

    2016-05-16

    This article emphasises that when working with complex adaptive systems it is possible to stimulate new social practices and/or cognitive perspectives that contribute to risk reduction, associated with reducing aggregate community viral loads. The process of achieving this is highly participatory and is methodologically possible because evidence of 'attractors' that influence the social practices can be identified using qualitative research techniques. Using findings from Limpopo Province, South Africa, we argue that working with 'wellness attractors' and increasing their presence within the HIV/AIDS landscape could influence aggregate community viral loads. While the analysis that is presented is unconventional, it is plausible that this perspective may hold potential to develop a biosocial response - which the Joint United Nations Programme on HIV and AIDS (UNAIDS) has called for - that reinforces the biomedical opportunities that are now available to achieve the ambition of ending AIDS by 2030.

  1. Oxidation of cefazolin by potassium permanganate: Transformation products and plausible pathways.

    Science.gov (United States)

    Li, Liping; Wei, Dongbin; Wei, Guohua; Du, Yuguo

    2016-04-01

    Cefazolin was demonstrated to exert high reactivity toward permanganate (Mn(VII)), a common oxidant in water pre-oxidation treatment. In this study, five transformation products were found to be classified into three categories according to the contained characteristic functional groups: three (di-)sulfoxide products, one sulfone product and one di-ketone product. Products analyses showed that two kinds of reactions including oxidation of thioether and the cleavage of unsaturated CC double bond occurred during transformation of cefazolin by Mn(VII). Subsequently, the plausible transformation pathways under different pH conditions were proposed based on the identified products and chemical reaction principles. More importantly, the simulation with real surface water matrix indicated that the proposed transformation pathways of cefazolin could be replayed in real water treatment practices.

  2. Plausible authentication of manuka honey and related products by measuring leptosperin with methyl syringate.

    Science.gov (United States)

    Kato, Yoji; Fujinaka, Rie; Ishisaka, Akari; Nitta, Yoko; Kitamoto, Noritoshi; Takimoto, Yosuke

    2014-07-01

    Manuka honey, obtained from Leptospermum scoparium flowers in New Zealand, has strong antibacterial properties. In this study, plausible authentication of the manuka honey was inspected by measuring leptosperin, methyl syringate 4-O-β-D-gentiobiose, along with methyl syringate. Despite a gradual decrease in methyl syringate content over 30 days at 50 °C, even at moderate 37 °C, leptosperin remained stable. A considerable correlation between nonperoxide antibacterial activity and leptosperin content was observed in 20 certified manuka honey samples. Leptosperin and methyl syringate in manuka honey and related products were analyzed using HPLC connected with mass spectrometry. One noncertified brand displayed significant variations in the leptosperin and methyl syringate contents between two samples obtained from different regions. Therefore, certification is clearly required to protect consumers from disguised and/or low-quality honey. Because leptosperin is stable during storage and specific to manuka honey, its measurement may be applicable for manuka honey authentication.

  3. A plausible simultaneous synthesis of amino acids and simple peptides on the primordial Earth.

    Science.gov (United States)

    Parker, Eric T; Zhou, Manshui; Burton, Aaron S; Glavin, Daniel P; Dworkin, Jason P; Krishnamurthy, Ramanarayanan; Fernández, Facundo M; Bada, Jeffrey L

    2014-07-28

    Following his seminal work in 1953, Stanley Miller conducted an experiment in 1958 to study the polymerization of amino acids under simulated early Earth conditions. In the experiment, Miller sparked a gas mixture of CH4, NH3, and H2O, while intermittently adding the plausible prebiotic condensing reagent cyanamide. For unknown reasons, an analysis of the samples was not reported. We analyzed the archived samples for amino acids, dipeptides, and diketopiperazines by liquid chromatography, ion mobility spectrometry, and mass spectrometry. A dozen amino acids, 10 glycine-containing dipeptides, and 3 glycine-containing diketopiperazines were detected. Miller's experiment was repeated and similar polymerization products were observed. Aqueous heating experiments indicate that Strecker synthesis intermediates play a key role in facilitating polymerization. These results highlight the potential importance of condensing reagents in generating diversity within the prebiotic chemical inventory.

  4. Evaluation and integration of cancer gene classifiers: identification and ranking of plausible drivers.

    Science.gov (United States)

    Liu, Yang; Tian, Feng; Hu, Zhenjun; DeLisi, Charles

    2015-05-11

    The number of mutated genes in cancer cells is far larger than the number of mutations that drive cancer. The difficulty this creates for identifying relevant alterations has stimulated the development of various computational approaches to distinguishing drivers from bystanders. We develop and apply an ensemble classifier (EC) machine learning method, which integrates 10 classifiers that are publically available, and apply it to breast and ovarian cancer. In particular we find the following: (1) Using both standard and non-standard metrics, EC almost always outperforms single method classifiers, often by wide margins. (2) Of the 50 highest ranked genes for breast (ovarian) cancer, 34 (30) are associated with other cancers in either the OMIM, CGC or NCG database (P plausible. Biological implications are briefly discussed. Source codes and detailed results are available at http://www.visantnet.org/misi/driver_integration.zip.

  5. Probability, plausibility, and adequacy evaluations of the Oriente Study demonstrate that supplementation improved child growth.

    Science.gov (United States)

    Habicht, Jean-Pierre; Martorell, Reynaldo

    2010-02-01

    This article presents evidence that the high-nutrient supplement in the Oriente study (Atole) improved child growth. The evidence is presented at 4 levels. There was a causal effect of the intervention on child length, as assessed by probability analyses of the randomized, controlled trial (P < 0.05). The plausibility analyses, which included an examination of wasting, showed that the nutritional impact was due to the Atole, especially in those who were <3 y old and who suffered from diarrhea. The adequacy analyses revealed excellent biological efficacy of the Atole at the individual level. At the level of the whole population, the efficacy of impact was much less, because many children did not participate fully in the supplementation program. The external validity of the biological impact is likely to be good for populations with similar diets and medical care.

  6. The Sarrazin effect: the presence of absurd statements in conspiracy theories makes canonical information less plausible

    Directory of Open Access Journals (Sweden)

    Marius Hans Raab

    2013-07-01

    Full Text Available Reptile prime ministers and flying Nazi saucers—extreme and sometimes off-wall conclusion are common ingredients of conspiracy theories. While individual differences are a common research topic concerning conspiracy theories, the role of extreme statements in the process of acquiring and passing on conspiratorial stories has not been regarded in an experimental design so far. We identified six morphological components of conspiracy theories empirically. On the basis of these content categories a set of narrative elements for a 9/11 story was compiled. These elements varied systematically in terms of conspiratorial allegation, i.e., they contained official statements concerning the events of 9/11, statements alleging to a conspiracy limited in time and space as well as extreme statements indicating an all-encompassing cover-up. Using the method of narrative construction, 30 people were given a set of cards with these statements and asked to construct the course of events of 9/11 they deem most plausible. When extreme statements were present in the set, the resulting stories were more conspiratorial; the number of official statements included in the narrative dropped significantly, whereas the self-assessment of the story’s plausibility did not differ between conditions. This indicates that blatant statements in a pool of information foster the synthesis of conspiracy theories on an individual level. By relating these findings to one of Germany’s most successful (and controversial non-fiction books, we refer to the real-world dangers of this effect.

  7. Alternative wastewatersystems

    DEFF Research Database (Denmark)

    Dyck-Madsen, Søren; Hoffmann, Birgitte; Gabriel, Søren

    1999-01-01

    The report:-  Communicates experiences from Swedish buildings from the establishment and running of alternative wastewater systems. Communicates pictures of alternative buildings and wastewater systems in Sweden. Gives a short evaluation of the performance and the sustainability of the systems....

  8. Policy Research Using Agent-Based Modeling to Assess Future Impacts of Urban Expansion into Farmlands and Forests

    Directory of Open Access Journals (Sweden)

    Michael R. Guzy

    2008-06-01

    Full Text Available The expansion of urban land uses into farmlands and forests requires an assessment of future ecological impacts. Spatially explicit agent-based models can represent the changes in resilience and ecological services that result from different land-use policies. When modeling complex adaptive systems, both the methods used to interpret results and the standards of rigor used to judge adequacy are complicated and require additional research. Recent studies suggest that it would be appropriate to use these models as an extension of exploratory analysis. This type of analysis generates ensembles of alternate plausible representations of future system conditions. User expertise steers interactive, stepwise system exploration toward inductive reasoning about potential changes to the system. In this study, we develop understanding of the potential alternative futures for a social-ecological system by way of successive simulations that test variations in the types and numbers of policies. The model addresses the agricultural-urban interface and the preservation of ecosystem services. The landscape analyzed is at the junction of the McKenzie and Willamette Rivers adjacent to the cities of Eugene and Springfield in Lane County, Oregon. Our exploration of alternative future scenarios suggests that policies that constrain urban growth and create incentives for farming and forest enterprises to preserve and enhance habitat can protect ecosystem resilience and services.

  9. Future-Orientated Approaches to Curriculum Development: Fictive Scripting

    Science.gov (United States)

    Garraway, James

    2017-01-01

    Though the future cannot be accurately predicted, it is possible to envisage a number of probable developments which can promote thinking about the future and so promote a more informed stance about what should or should not be done. Studies in technology and society have claimed that the use of a type of forecasting using plausible but imaginary…

  10. Future-Orientated Approaches to Curriculum Development: Fictive Scripting

    Science.gov (United States)

    Garraway, James

    2017-01-01

    Though the future cannot be accurately predicted, it is possible to envisage a number of probable developments which can promote thinking about the future and so promote a more informed stance about what should or should not be done. Studies in technology and society have claimed that the use of a type of forecasting using plausible but imaginary…

  11. Alternative metrics

    Science.gov (United States)

    2012-11-01

    As the old 'publish or perish' adage is brought into question, additional research-impact indices, known as altmetrics, are offering new evaluation alternatives. But such metrics may need to adjust to the evolution of science publishing.

  12. Scheduling and adaptation of London's future water supply and demand schemes under uncertainty

    Science.gov (United States)

    Huskova, Ivana; Matrosov, Evgenii S.; Harou, Julien J.; Kasprzyk, Joseph R.; Reed, Patrick M.

    2015-04-01

    The changing needs of society and the uncertainty of future conditions complicate the planning of future water infrastructure and its operating policies. These systems must meet the multi-sector demands of a range of stakeholders whose objectives often conflict. Understanding these conflicts requires exploring many alternative plans to identify possible compromise solutions and important system trade-offs. The uncertainties associated with future conditions such as climate change and population growth challenge the decision making process. Ideally planners should consider portfolios of supply and demand management schemes represented as dynamic trajectories over time able to adapt to the changing environment whilst considering many system goals and plausible futures. Decisions can be scheduled and adapted over the planning period to minimize the present cost of portfolios while maintaining the supply-demand balance and ecosystem services as the future unfolds. Yet such plans are difficult to identify due to the large number of alternative plans to choose from, the uncertainty of future conditions and the computational complexity of such problems. Our study optimizes London's future water supply system investments as well as their scheduling and adaptation over time using many-objective scenario optimization, an efficient water resource system simulator, and visual analytics for exploring key system trade-offs. The solutions are compared to Pareto approximate portfolios obtained from previous work where the composition of infrastructure portfolios that did not change over the planning period. We explore how the visual analysis of solutions can aid decision making by investigating the implied performance trade-offs and how the individual schemes and their trajectories present in the Pareto approximate portfolios affect the system's behaviour. By doing so decision makers are given the opportunity to decide the balance between many system goals a posteriori as well as

  13. Semantics-based plausible reasoning to extend the knowledge coverage of medical knowledge bases for improved clinical decision support.

    Science.gov (United States)

    Mohammadhassanzadeh, Hossein; Van Woensel, William; Abidi, Samina Raza; Abidi, Syed Sibte Raza

    2017-01-01

    Capturing complete medical knowledge is challenging-often due to incomplete patient Electronic Health Records (EHR), but also because of valuable, tacit medical knowledge hidden away in physicians' experiences. To extend the coverage of incomplete medical knowledge-based systems beyond their deductive closure, and thus enhance their decision-support capabilities, we argue that innovative, multi-strategy reasoning approaches should be applied. In particular, plausible reasoning mechanisms apply patterns from human thought processes, such as generalization, similarity and interpolation, based on attributional, hierarchical, and relational knowledge. Plausible reasoning mechanisms include inductive reasoning, which generalizes the commonalities among the data to induce new rules, and analogical reasoning, which is guided by data similarities to infer new facts. By further leveraging rich, biomedical Semantic Web ontologies to represent medical knowledge, both known and tentative, we increase the accuracy and expressivity of plausible reasoning, and cope with issues such as data heterogeneity, inconsistency and interoperability. In this paper, we present a Semantic Web-based, multi-strategy reasoning approach, which integrates deductive and plausible reasoning and exploits Semantic Web technology to solve complex clinical decision support queries. We evaluated our system using a real-world medical dataset of patients with hepatitis, from which we randomly removed different percentages of data (5%, 10%, 15%, and 20%) to reflect scenarios with increasing amounts of incomplete medical knowledge. To increase the reliability of the results, we generated 5 independent datasets for each percentage of missing values, which resulted in 20 experimental datasets (in addition to the original dataset). The results show that plausibly inferred knowledge extends the coverage of the knowledge base by, on average, 2%, 7%, 12%, and 16% for datasets with, respectively, 5%, 10%, 15%, and

  14. Biologic plausibility, cellular effects, and molecular mechanisms of eicosapentaenoic acid (EPA) in atherosclerosis.

    Science.gov (United States)

    Borow, Kenneth M; Nelson, John R; Mason, R Preston

    2015-09-01

    Residual cardiovascular (CV) risk remains in dyslipidemic patients despite intensive statin therapy, underscoring the need for additional intervention. Eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid, is incorporated into membrane phospholipids and atherosclerotic plaques and exerts beneficial effects on the pathophysiologic cascade from onset of plaque formation through rupture. Specific salutary actions have been reported relating to endothelial function, oxidative stress, foam cell formation, inflammation, plaque formation/progression, platelet aggregation, thrombus formation, and plaque rupture. EPA also improves atherogenic dyslipidemia characterized by reduction of triglycerides without raising low-density lipoprotein cholesterol. Other beneficial effects of EPA include vasodilation, resulting in blood pressure reductions, as well as improved membrane fluidity. EPA's effects are at least additive to those of statins when given as adjunctive therapy. In this review, we present data supporting the biologic plausibility of EPA as an anti-atherosclerotic agent with potential clinical benefit for prevention of CV events, as well as its cellular effects and molecular mechanisms of action. REDUCE-IT is an ongoing, randomized, controlled study evaluating whether the high-purity ethyl ester of EPA (icosapent ethyl) at 4 g/day combined with statin therapy is superior to statin therapy alone for reducing CV events in high-risk patients with mixed dyslipidemia. The results from this study are expected to clarify the role of EPA as adjunctive therapy to a statin for reduction of residual CV risk.

  15. Mindfulness and Cardiovascular Disease Risk: State of the Evidence, Plausible Mechanisms, and Theoretical Framework.

    Science.gov (United States)

    Loucks, Eric B; Schuman-Olivier, Zev; Britton, Willoughby B; Fresco, David M; Desbordes, Gaelle; Brewer, Judson A; Fulwiler, Carl

    2015-12-01

    The purpose of this review is to provide (1) a synopsis on relations of mindfulness with cardiovascular disease (CVD) and major CVD risk factors, and (2) an initial consensus-based overview of mechanisms and theoretical framework by which mindfulness might influence CVD. Initial evidence, often of limited methodological quality, suggests possible impacts of mindfulness on CVD risk factors including physical activity, smoking, diet, obesity, blood pressure, and diabetes regulation. Plausible mechanisms include (1) improved attention control (e.g., ability to hold attention on experiences related to CVD risk, such as smoking, diet, physical activity, and medication adherence), (2) emotion regulation (e.g., improved stress response, self-efficacy, and skills to manage craving for cigarettes, palatable foods, and sedentary activities), and (3) self-awareness (e.g., self-referential processing and awareness of physical sensations due to CVD risk factors). Understanding mechanisms and theoretical framework should improve etiologic knowledge, providing customized mindfulness intervention targets that could enable greater mindfulness intervention efficacy.

  16. A plausible (overlooked) super-luminous supernova in the SDSS Stripe 82 data

    CERN Document Server

    Kostrzewa-Rutkowska, Zuzanna; Wyrzykowski, Lukasz; Djorgovski, S George; Glikman, Eilat; Mahabal, Ashish A

    2013-01-01

    We present the discovery of a plausible super-luminous supernova (SLSN), found in the archival data of Sloan Digital Sky Survey (SDSS) Stripe 82, called PSN 000123+000504. The supernova peaked at M_g<-21.3 mag in the second half of September 2005, but was missed by the real-time supernova hunt. The observed part of the light curve (17 epochs) showed that the rise to the maximum took over 30 days, while the decline time lasted at least 70 days (observed frame), closely resembling other SLSNe of SN2007bi type. Spectrum of the host galaxy reveals a redshift of z=0.281 and the distance modulus of \\mu=40.77 mag. Combining this information with the SDSS photometry, we found the host galaxy to be an LMC-like irregular dwarf galaxy with the absolute magnitude of M_B=-18.2+/-0.2 mag and the oxygen abundance of 12+log[O/H]=8.3+/-0.2. Our SLSN follows the relation for the most energetic/super-luminous SNe exploding in low-metallicity environments, but we found no clear evidence for SLSNe to explode in low-luminosity ...

  17. Event-based plausibility immediately influences on-line language comprehension.

    Science.gov (United States)

    Matsuki, Kazunaga; Chow, Tracy; Hare, Mary; Elman, Jeffrey L; Scheepers, Christoph; McRae, Ken

    2011-07-01

    In some theories of sentence comprehension, linguistically relevant lexical knowledge, such as selectional restrictions, is privileged in terms of the time-course of its access and influence. We examined whether event knowledge computed by combining multiple concepts can rapidly influence language understanding even in the absence of selectional restriction violations. Specifically, we investigated whether instruments can combine with actions to influence comprehension of ensuing patients of (as in Rayner, Warren, Juhuasz, & Liversedge, 2004; Warren & McConnell, 2007). Instrument-verb-patient triplets were created in a norming study designed to tap directly into event knowledge. In self-paced reading (Experiment 1), participants were faster to read patient nouns, such as hair, when they were typical of the instrument-action pair (Donna used the shampoo to wash vs. the hose to wash). Experiment 2 showed that these results were not due to direct instrument-patient relations. Experiment 3 replicated Experiment 1 using eyetracking, with effects of event typicality observed in first fixation and gaze durations on the patient noun. This research demonstrates that conceptual event-based expectations are computed and used rapidly and dynamically during on-line language comprehension. We discuss relationships among plausibility and predictability, as well as their implications. We conclude that selectional restrictions may be best considered as event-based conceptual knowledge rather than lexical-grammatical knowledge.

  18. From ether to acid: A plausible degradation pathway of glycerol dialkyl glycerol tetraethers

    Science.gov (United States)

    Liu, Xiao-Lei; Birgel, Daniel; Elling, Felix J.; Sutton, Paul A.; Lipp, Julius S.; Zhu, Rong; Zhang, Chuanlun; Könneke, Martin; Peckmann, Jörn; Rowland, Steven J.; Summons, Roger E.; Hinrichs, Kai-Uwe

    2016-06-01

    Glycerol dialkyl glycerol tetraethers (GDGTs) are ubiquitous microbial lipids with extensive demonstrated and potential roles as paleoenvironmental proxies. Despite the great attention they receive, comparatively little is known regarding their diagenetic fate. Putative degradation products of GDGTs, identified as hydroxyl and carboxyl derivatives, were detected in lipid extracts of marine sediment, seep carbonate, hot spring sediment and cells of the marine thaumarchaeon Nitrosopumilus maritimus. The distribution of GDGT degradation products in environmental samples suggests that both biotic and abiotic processes act as sinks for GDGTs. More than a hundred newly recognized degradation products afford a view of the stepwise degradation of GDGT via (1) ether bond hydrolysis yielding hydroxyl isoprenoids, namely, GDGTol (glycerol dialkyl glycerol triether alcohol), GMGD (glycerol monobiphytanyl glycerol diether), GDD (glycerol dibiphytanol diether), GMM (glycerol monobiphytanol monoether) and bpdiol (biphytanic diol); (2) oxidation of isoprenoidal alcohols into corresponding carboxyl derivatives and (3) chain shortening to yield C39 and smaller isoprenoids. This plausible GDGT degradation pathway from glycerol ethers to isoprenoidal fatty acids provides the link to commonly detected head-to-head linked long chain isoprenoidal hydrocarbons in petroleum and sediment samples. The problematic C80 to C82 tetraacids that cause naphthenate deposits in some oil production facilities can be generated from H-shaped glycerol monoalkyl glycerol tetraethers (GMGTs) following the same process, as indicated by the distribution of related derivatives in hydrothermally influenced sediments.

  19. Plausible molecular and crystal structures of chitosan/HI type II salt.

    Science.gov (United States)

    Lertworasirikul, Amornrat; Noguchi, Keiichi; Ogawa, Kozo; Okuyama, Kenji

    2004-03-15

    Chitosan/HI type II salt prepared from crab tendon was investigated by X-ray fiber diffraction. Two polymer chains and 16 iodide ions (I(-)) crystallized in a tetragonal unit cell with lattice parameters of a = b = 10.68(3), c (fiber axis) = 40.77(13) A, and a space group P4(1). Chitosan forms a fourfold helix with a 40.77 A fiber period having a disaccharide as the helical asymmetric unit. One of the O-3... O-5 intramolecular hydrogen bonds at the glycosidic linkage is weakened by interacting with iodide ions, which seems to cause the polymer to take the 4/1-helical symmetry rather than the extended 2/1-helix. The plausible orientations of two O-6 atoms in the helical asymmetric unit were found to be gt and gg. Two chains are running through at the corner and the center of the unit cell along the c-axis. They are linked by hydrogen bonds between N-21 and O-61 atoms. Two out of four independent iodide ions are packed between the corner chains while the other two are packed between the corner and center chains when viewing through the ab-plane. The crystal structure of the salt is stabilized by hydrogen bonds between these iodide ions and N-21, N-22, O-32, O-61, O-62 of the polymer chains.

  20. Solvent effects on the photochemistry of 4-aminoimidazole-5-carbonitrile, a prebiotically plausible precursor of purines.

    Science.gov (United States)

    Szabla, Rafał; Sponer, Judit E; Sponer, Jiří; Sobolewski, Andrzej L; Góra, Robert W

    2014-09-01

    4-Aminoimidazole-5-carbonitrile (AICN) was suggested as a prebiotically plausible precursor of purine nucleobases and nucleotides. Although it can be formed in a sequence of photoreactions, AICN is immune to further irradiation with UV-light. We present state-of-the-art multi-reference quantum-chemical calculations of potential energy surface cuts and conical intersection optimizations to explain the molecular mechanisms underlying the photostability of this compound. We have identified the N-H bond stretching and ring-puckering mechanisms that should be responsible for the photochemistry of AICN in the gas phase. We have further considered the photochemistry of AICN-water clusters, while including up to six explicit water molecules. The calculations reveal charge transfer to solvent followed by formation of an H3O(+) cation, both of which occur on the (1)πσ* hypersurface. Interestingly, a second proton transfer to an adjacent water molecule leads to a (1)πσ*/S0 conical intersection. We suggest that this electron-driven proton relay might be characteristic of low-lying (1)πσ* states in chromophore-water clusters. Owing to its nature, this mechanism might also be responsible for the photostability of analogous organic molecules in bulk water.

  1. A biologically plausible learning rule for the Infomax on recurrent neural networks.

    Science.gov (United States)

    Hayakawa, Takashi; Kaneko, Takeshi; Aoyagi, Toshio

    2014-01-01

    A fundamental issue in neuroscience is to understand how neuronal circuits in the cerebral cortex play their functional roles through their characteristic firing activity. Several characteristics of spontaneous and sensory-evoked cortical activity have been reproduced by Infomax learning of neural networks in computational studies. There are, however, still few models of the underlying learning mechanisms that allow cortical circuits to maximize information and produce the characteristics of spontaneous and sensory-evoked cortical activity. In the present article, we derive a biologically plausible learning rule for the maximization of information retained through time in dynamics of simple recurrent neural networks. Applying the derived learning rule in a numerical simulation, we reproduce the characteristics of spontaneous and sensory-evoked cortical activity: cell-assembly-like repeats of precise firing sequences, neuronal avalanches, spontaneous replays of learned firing sequences and orientation selectivity observed in the primary visual cortex. We further discuss the similarity between the derived learning rule and the spike timing-dependent plasticity of cortical neurons.

  2. Plausible ergogenic effects of vitamin D on athletic performance and recovery.

    Science.gov (United States)

    Dahlquist, Dylan T; Dieter, Brad P; Koehle, Michael S

    2015-01-01

    The purpose of this review is to examine vitamin D in the context of sport nutrition and its potential role in optimizing athletic performance. Vitamin D receptors (VDR) and vitamin D response elements (VDREs) are located in almost every tissue within the human body including skeletal muscle. The hormonally-active form of vitamin D, 1,25-dihydroxyvitamin D, has been shown to play critical roles in the human body and regulates over 900 gene variants. Based on the literature presented, it is plausible that vitamin D levels above the normal reference range (up to 100 nmol/L) might increase skeletal muscle function, decrease recovery time from training, increase both force and power production, and increase testosterone production, each of which could potentiate athletic performance. Therefore, maintaining higher levels of vitamin D could prove beneficial for athletic performance. Despite this situation, large portions of athletic populations are vitamin D deficient. Currently, the research is inconclusive with regards to the optimal intake of vitamin D, the specific forms of vitamin D one should ingest, and the distinct nutrient-nutrient interactions of vitamin D with vitamin K that affect arterial calcification and hypervitaminosis. Furthermore, it is possible that dosages exceeding the recommendations for vitamin D (i.e. dosages up to 4000-5000 IU/day), in combination with 50 to 1000 mcg/day of vitamin K1 and K2 could aid athletic performance. This review will investigate these topics, and specifically their relevance to athletic performance.

  3. A simple biophysically plausible model for long time constants in single neurons.

    Science.gov (United States)

    Tiganj, Zoran; Hasselmo, Michael E; Howard, Marc W

    2015-01-01

    Recent work in computational neuroscience and cognitive psychology suggests that a set of cells that decay exponentially could be used to support memory for the time at which events took place. Analytically and through simulations on a biophysical model of an individual neuron, we demonstrate that exponentially decaying firing with a range of time constants up to minutes could be implemented using a simple combination of well-known neural mechanisms. In particular, we consider firing supported by calcium-controlled cation current. When the amount of calcium leaving the cell during an interspike interval is larger than the calcium influx during a spike, the overall decay in calcium concentration can be exponential, resulting in exponential decay of the firing rate. The time constant of the decay can be several orders of magnitude larger than the time constant of calcium clearance, and it could be controlled externally via a variety of biologically plausible ways. The ability to flexibly and rapidly control time constants could enable working memory of temporal history to be generalized to other variables in computing spatial and ordinal representations.

  4. A plausible mechanism of biosorption in dual symbioses by vesicular-arbuscular mycorrhizal in plants.

    Science.gov (United States)

    Azmat, Rafia; Hamid, Neelofer

    2015-03-01

    Dual symbioses of vesicular-arbuscular mycorrhizal (VAM) fungi with growth of Momordica charantia were elucidated in terms of plausible mechanism of biosorption in this article. The experiment was conducted in green house and mixed inoculum of the VAM fungi was used in the three replicates. Results demonstrated that the starch contents were the main source of C for the VAM to builds their hyphae. The increased plant height and leaves surface area were explained in relation with an increase in the photosynthetic rates to produce rapid sugar contents for the survival of plants. A decreased in protein, and amino acid contents and increased proline and protease activity in VAM plants suggested that these contents were the main bio-indicators of the plants under biotic stress. The decline in protein may be due to the degradation of these contents, which later on converted into dextrose where it can easily be absorbed by for the period of symbioses. A mechanism of C chemisorption in relation with physiology and morphology of plant was discussed.

  5. Vitamin D in primary biliary cirrhosis, a plausible marker of advanced disease.

    Science.gov (United States)

    Agmon-Levin, Nancy; Kopilov, Ron; Selmi, Carlo; Nussinovitch, Udi; Sánchez-Castañón, María; López-Hoyos, Marcos; Amital, Howie; Kivity, Shaye; Gershwin, Eric M; Shoenfeld, Yehuda

    2015-02-01

    Vitamin D immune-modulating effects were extensively studied, and low levels have been linked with autoimmune diseases. The associations of vitamin D with autoimmune diseases of the liver, and particularly primary biliary cirrhosis (PBC), are yet to be defined. Hence, in this study, serum levels of vitamin D were determined in 79 patients with PBC and 70 age- and sex-matched controls by the LIAISON chemiluminescent immunoassays (DiaSorin-Italy). Clinical and serological parameters of patients were analyzed with respect to vitamin D status. Mean levels of vitamin D were significantly lower among patients with PBC compared with controls (16.8 ± 9 vs. 22.1 ± 9 ng/ml; p = 0.029), and vitamin D deficiency (≤10 ng/ml) was documented in 33% of patients with PBC versus 7% of controls (p plausible roles of vitamin D as a prognostic marker of PBC severity, and as a potential player in this disease pathogenesis. While further studies are awaited, monitoring vitamin D in patients with PBC and use of supplements may be advisable.

  6. Plausible impact of global climate change on water resources in the Tarim River Basin

    Institute of Scientific and Technical Information of China (English)

    CHEN; Yaning; XU; Zongxue

    2005-01-01

    Combining the temperature and precipitation data from 77 climatological stations and the climatic and hydrological change data from three headstreams of the Tarim River: Hotan, Yarkant, and Aksu in the study area, the plausible association between climate change and the variability of water resources in the Tarim River Basin in recent years was investigated, the long-term trend of the hydrological time series including temperature, precipitation, and streamflow was detected, and the possible association between the El Ni(n)o/Southern Oscillation (ENSO) and these three kinds of time series was tested. The results obtained in this study show that during the past years, the temperature experienced a significant monotonic increase at the speed of 5%, nearly 1℃ rise; the precipitation showed a significant decrease in the 1970s, and a significant increase in the1980s and 1990s, the average annual precipitation was increased with the magnitude of 6.8 mm per decade. A step change occurred in both temperature and precipitation time series around 1986, which may be influenced by the global climate change. Climate change resulted in the increase of the streamflow at the headwater of the Tarim River, but the anthropogenic activities such as over-depletion of the surface water resulted in the decrease of the streamflow at the lower reaches of the Tarim River. The study result also showed that there is no significant association between the ENSO and the temperature, precipitation and streamflow.

  7. Cultural group selection is plausible, but the predictions of its hypotheses should be tested with real-world data.

    Science.gov (United States)

    Turchin, Peter; Currie, Thomas E

    2016-01-01

    The evidence compiled in the target article demonstrates that the assumptions of cultural group selection (CGS) theory are often met, and it is therefore a useful framework for generating plausible hypotheses. However, more can be said about how we can test the predictions of CGS hypotheses against competing explanations using historical, archaeological, and anthropological data.

  8. Alternative Veier

    DEFF Research Database (Denmark)

    Kruse, Tove Elisabeth; Salamonsen, Anita

    reflektioner omkring patienters brug af og erfaringer med alternativ behandling. Patientorganisationer, organisatoner for alternative behandlere og organisationer for læger og medicinstuderende har læst bogens patienthistorier og deres perspektiver lægges frem. Til slut i bogen diskuteres betydningen af de...

  9. Growing Alternatives

    DEFF Research Database (Denmark)

    Bagger-Petersen, Mai Corlin

    2014-01-01

    From 2014, Anhui Province will pilot a reform of the residential land market in China, thus integrating rural Anhui in the national housing market. In contrast, artist and activist Ou Ning has proposed the Bishan time money currency, intending to establish an alternative economic circuit in Bishan...

  10. Magnetostrictive Alternator

    Science.gov (United States)

    Dyson, Rodger; Bruder, Geoffrey

    2013-01-01

    This innovation replaces the linear alternator presently used in Stirling engines with a continuous-gradient, impedance-matched, oscillating magnetostrictive transducer that eliminates all moving parts via compression, maintains high efficiency, costs less to manufacture, reduces mass, and eliminates the need for a bearing system. The key components of this new technology are the use of stacked magnetostrictive materials, such as Terfenol-D, under a biased magnetic and stress-induced compression, continuous-gradient impedance-matching material, coils, force-focusing metallic structure, and supports. The acoustic energy from the engine travels through an impedancematching layer that is physically connected to the magnetostrictive mass. Compression bolts keep the structure under compressive strain, allowing for the micron-scale compression of the magnetostrictive material and eliminating the need for bearings. The relatively large millimeter displacement of the pressure side of the impedance-matching material is reduced to micron motion, and undergoes stress amplification at the magnetostrictive interface. The alternating compression and expansion of the magnetostrictive material creates an alternating magnetic field that then induces an electric current in a coil that is wound around the stack. This produces electrical power from the acoustic pressure wave and, if the resonant frequency is tuned to match the engine, can replace the linear alternator that is commonly used.

  11. Alternative Treatments

    Science.gov (United States)

    ... triglyceride (fat) produced by processing coconut oil or palm kernel oil. The body breaks down caprylic acid into substances called “ketone bodies.” The theory behind Axona is that the ketone bodies derived from caprylic acid may provide an alternative energy source for brain cells that have lost ...

  12. Flux-based transport enhancement as a plausible unifying mechanism for auxin transport in meristem development.

    Directory of Open Access Journals (Sweden)

    Szymon Stoma

    2008-10-01

    Full Text Available Plants continuously generate new organs through the activity of populations of stem cells called meristems. The shoot apical meristem initiates leaves, flowers, and lateral meristems in highly ordered, spiralled, or whorled patterns via a process called phyllotaxis. It is commonly accepted that the active transport of the plant hormone auxin plays a major role in this process. Current hypotheses propose that cellular hormone transporters of the PIN family would create local auxin maxima at precise positions, which in turn would lead to organ initiation. To explain how auxin transporters could create hormone fluxes to distinct regions within the plant, different concepts have been proposed. A major hypothesis, canalization, proposes that the auxin transporters act by amplifying and stabilizing existing fluxes, which could be initiated, for example, by local diffusion. This convincingly explains the organised auxin fluxes during vein formation, but for the shoot apical meristem a second hypothesis was proposed, where the hormone would be systematically transported towards the areas with the highest concentrations. This implies the coexistence of two radically different mechanisms for PIN allocation in the membrane, one based on flux sensing and the other on local concentration sensing. Because these patterning processes require the interaction of hundreds of cells, it is impossible to estimate on a purely intuitive basis if a particular scenario is plausible or not. Therefore, computational modelling provides a powerful means to test this type of complex hypothesis. Here, using a dedicated computer simulation tool, we show that a flux-based polarization hypothesis is able to explain auxin transport at the shoot meristem as well, thus providing a unifying concept for the control of auxin distribution in the plant. Further experiments are now required to distinguish between flux-based polarization and other hypotheses.

  13. Identifying and reducing potentially wrong immunoassay results even when plausible and "not-unreasonable".

    Science.gov (United States)

    Ismail, Adel A A

    2014-01-01

    The primary role of the clinical laboratory is to report accurate results for diagnosis of disease and management of illnesses. This goal has, to a large extent been achieved for routine biochemical tests, but not for immunoassays which remained susceptible to interference from endogenous immunoglobulin antibodies, causing false, and clinically misleading results. Clinicians regard all abnormal results including false ones as "pathological" necessitating further investigations, or concluding iniquitous diagnosis. Even more seriously, "false-negative" results may wrongly exclude pathology, thus denying patients' necessary treatment. Analytical error rate in immunoassays is relatively high, ranging from 0.4% to 4.0%. Because analytical interference from endogenous antibodies is confined to individuals' sera, it can be inconspicuous, pernicious, sporadic, and insidious because it cannot be detected by internal or external quality assessment procedures. An approach based on Bayesian reasoning can enhance the robustness of clinical validation in highlighting potentially erroneous immunoassay results. When this rational clinical/statistical approach is followed by analytical affirmative follow-up tests, it can help identifying inaccurate and clinically misleading immunoassay data even when they appear plausible and "not-unreasonable." This chapter is largely based on peer reviewed articles associated with and related to this approach. The first section underlines (without mathematical equations) the dominance and misuse of conventional statistics and the underuse of Bayesian paradigm and shows that laboratorians are intuitively (albeit unwittingly) practicing Bayesians. Secondly, because interference from endogenous antibodies is method's dependent (with numerous formats and different reagents), it is almost impossible to accurately assess its incidence in all differently formulated immunoassays and for each analytes/biomarkers. However, reiterating the basic concepts

  14. A plausible (overlooked) super-luminous supernova in the Sloan digital sky survey stripe 82 data

    Energy Technology Data Exchange (ETDEWEB)

    Kostrzewa-Rutkowska, Zuzanna; Kozłowski, Szymon; Wyrzykowski, Łukasz [Warsaw University Observatory, Al. Ujazdowskie 4, 00-478 Warszawa (Poland); Djorgovski, S. George; Mahabal, Ashish A. [California Institute of Technology, 1200 E California Blvd., Pasadena, CA 91125 (United States); Glikman, Eilat [Department of Physics and Yale Center for Astronomy and Astrophysics, Yale University, P.O. Box 208121, New Haven, CT 06520-8121 (United States); Koposov, Sergey, E-mail: zkostrzewa@astrouw.edu.pl, E-mail: simkoz@astrouw.edu.pl, E-mail: wyrzykow@astrouw.edu.pl [Institute of Astronomy, University of Cambridge, Madingley Road, Cambridge CB3 0HA (United Kingdom)

    2013-12-01

    We present the discovery of a plausible super-luminous supernova (SLSN), found in the archival data of Sloan Digital Sky Survey (SDSS) Stripe 82, called PSN 000123+000504. The supernova (SN) peaked at m {sub g} < 19.4 mag in the second half of 2005 September, but was missed by the real-time SN hunt. The observed part of the light curve (17 epochs) showed that the rise to the maximum took over 30 days, while the decline time lasted at least 70 days (observed frame), closely resembling other SLSNe of SN 2007bi type. The spectrum of the host galaxy reveals a redshift of z = 0.281 and the distance modulus of μ = 40.77 mag. Combining this information with the SDSS photometry, we found the host galaxy to be an LMC-like irregular dwarf galaxy with an absolute magnitude of M{sub B} = –18.2 ± 0.2 mag and an oxygen abundance of 12+log [O/H]=8.3±0.2; hence, the SN peaked at M {sub g} < –21.3 mag. Our SLSN follows the relation for the most energetic/super-luminous SNe exploding in low-metallicity environments, but we found no clear evidence for SLSNe to explode in low-luminosity (dwarf) galaxies only. The available information on the PSN 000123+000504 light curve suggests the magnetar-powered model as a likely scenario of this event. This SLSN is a new addition to a quickly growing family of super-luminous SNe.

  15. Bio-physically plausible visualization of highly scattering fluorescent neocortical models for in silico experimentation

    KAUST Repository

    Abdellah, Marwan

    2017-02-15

    Background We present a visualization pipeline capable of accurate rendering of highly scattering fluorescent neocortical neuronal models. The pipeline is mainly developed to serve the computational neurobiology community. It allows the scientists to visualize the results of their virtual experiments that are performed in computer simulations, or in silico. The impact of the presented pipeline opens novel avenues for assisting the neuroscientists to build biologically accurate models of the brain. These models result from computer simulations of physical experiments that use fluorescence imaging to understand the structural and functional aspects of the brain. Due to the limited capabilities of the current visualization workflows to handle fluorescent volumetric datasets, we propose a physically-based optical model that can accurately simulate light interaction with fluorescent-tagged scattering media based on the basic principles of geometric optics and Monte Carlo path tracing. We also develop an automated and efficient framework for generating dense fluorescent tissue blocks from a neocortical column model that is composed of approximately 31000 neurons. Results Our pipeline is used to visualize a virtual fluorescent tissue block of 50 μm3 that is reconstructed from the somatosensory cortex of juvenile rat. The fluorescence optical model is qualitatively analyzed and validated against experimental emission spectra of different fluorescent dyes from the Alexa Fluor family. Conclusion We discussed a scientific visualization pipeline for creating images of synthetic neocortical neuronal models that are tagged virtually with fluorescent labels on a physically-plausible basis. The pipeline is applied to analyze and validate simulation data generated from neuroscientific in silico experiments.

  16. Alternative fuelds in urban fleets

    Energy Technology Data Exchange (ETDEWEB)

    Lindsay, T.

    1994-12-31

    In this presentation the author addresses four main objectives. They are to: discuss programs that are driving the introduction of alternative fuels into fleet operations in urban areas around the country; define alternative fuels; quantify the present use and future projections on alternative fuel vehicles (AVFs) in the Chicago metropolitan statistical area; and discuss benefits of increased use of alternative fuels in urban areas. Factors which touch on these points include: present domestic dependence on petroleum for autos, with usage exceeding production; the large populations in urban areas which do not meet Clean Air Standards; recent legislative initiatives which give guidance and aid in the adoption of such strategies.

  17. Differences in the Weighting and Choice of Evidence for Plausible versus Implausible Causes

    Science.gov (United States)

    Goedert, Kelly M.; Ellefson, Michelle R.; Rehder, Bob

    2014-01-01

    Individuals have difficulty changing their causal beliefs in light of contradictory evidence. We hypothesized that this difficulty arises because people facing implausible causes give greater consideration to causal alternatives, which, because of their use of a positive test strategy, leads to differential weighting of contingency evidence.…

  18. Evaluation of alternatives for the future of facilities at the Western New York Nuclear Service Center. [State and NRC-licensed burial areas; low-level liquid waste treatment facilities

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-08-01

    Regulatory considerations are discussed. Alternatives for the continued operation or decommissioning of the state-licensed burial area, the low-level waste treatment facilities, and the NRC licensed burial area are evaluated. Radiological impact analyses were also performed for alternatives on other facilities. (DLC)

  19. The SAFRR Tsunami Scenario: Improving Resilience for California from a Plausible M9 Earthquake near the Alaska Peninsula

    Science.gov (United States)

    Ross, S.; Jones, L.; Wilson, R. I.; Bahng, B.; Barberopoulou, A.; Borrero, J. C.; Brosnan, D.; Bwarie, J.; Geist, E. L.; Johnson, L.; Kirby, S. H.; Knight, W.; Long, K.; Lynett, P. J.; Miller, K.; Mortensen, C. E.; Nicolsky, D.; Oglesby, D. D.; Perry, S. C.; Plumlee, G. S.; Porter, K. A.; Real, C. R.; Ryan, K. J.; Suleimani, E.; Thio, H. K.; Titov, V.; Wein, A. M.; Whitmore, P.; Wood, N. J.

    2013-12-01

    The SAFRR Tsunami Scenario models a hypothetical but plausible tsunami, created by an Mw9.1 earthquake occurring offshore from the Alaskan peninsula, and its impacts on the California coast. We present the likely inundation areas, current velocities in key ports and harbors, physical damage and repair costs, economic consequences, environmental impacts, social vulnerability, emergency management, and policy implications for California associated with the tsunami scenario. The intended users are those who must make mitigation decisions before and rapid decisions during future tsunamis. Around a half million people would be present in the scenario's inundation area in residences, businesses, public venues, parks and beaches. Evacuation would likely be ordered for the State of California's maximum mapped tsunami inundation zone, evacuating an additional quarter million people from residences and businesses. Some island and peninsula communities would face particular evacuation challenges because of limited access options and short warning time, caused by the distance between Alaska and California. Evacuations may also be a challenge for certain dependent-care populations. One third of the boats in California's marinas could be damaged or sunk, costing at least 700 million in repairs to boats and docks, and potentially much more to address serious issues due to sediment transport and environmental contamination. Fires would likely start at many sites where fuel and petrochemicals are stored in ports and marinas. Tsunami surges and bores may travel several miles inland up coastal rivers. Debris clean-up and recovery of inundated and damaged areas will take days, months, or years depending on the severity of impacts and the available resources for recovery. The Ports of Los Angeles and Long Beach (POLA/LB) would be shut down for a miniμm of two days due to strong currents. Inundation of dry land in the ports would result in 100 million damages to cargo and additional

  20. Plausible antioxidant biomechanics and anticonvulsant pharmacological activity of brain-targeted β-carotene nanoparticles.

    Science.gov (United States)

    Yusuf, Mohammad; Khan, Riaz A; Khan, Maria; Ahmed, Bahar

    2012-01-01

    increased in P-80-BCNP to 231.0 ± 16.30 seconds, as compared to PTZ (120.10 ± 4.50 seconds) and placebo control (120.30 ± 7.4 seconds). The results of this study demonstrate a plausible novel anticonvulsant activity of β-carotene at a low dose of 2 mg/kg, with brain-targeted nanodelivery, thus increasing its bioavailability and stability.

  1. Plausibility check of a redesigned rain-on-snow simulator (RASA)

    Science.gov (United States)

    Rössler, Ole; Probst, Sabine; Weingartner, Rolf

    2016-04-01

    Rain-on-snow events are fascinating but still not completely understood processes. Although, several studies and equations have been published since decades that describe past events and theoretical descriptions, empirical data of what is happening in the snow cover is far less available. A way to fill this gap of empirical data, rain-on-snow-simulators might be of help. In 2013, Juras et al. published their inspiring idea of a portable rain-on-snow simulator. The huge advantage of this devise - in contrast to other purely field-based experiments - are their fixed, and mostly standardized conditions and the possibility to measure all required data to monitor the water fluxes and melting processes at a time. Mounted in a convenient location, a large number of experiments are relatively easy conductible. We applied and further developed the original device and plausified the results of this redesigned version, called RASA. The principal design was borrowed from the original version being a frame with a sprinkler on top and a snow sample in a box at the bottom, from which the outflow is measured with a tipping gauge. We added a moving sprinkling plate to ensure a uniform distribution of raindrops on the snow, and - most importantly - we suspended the watered snow sampled on weighting cells. The latter enables to continuous measurement of the snow sample throughout the experiment and thus the indirect quantification of liquid water saturation, water holding capacity, and snowmelt amount via balance equations. As it is remains unclear if this device is capable to reproduce known processes, a hypothesis based plausibility check was accomplished. Thus, eight hypothesizes were derived from literature and tested in 28 experiments with the RASA mounted at 2000 m elevation. In general, we were able to reproduce most of the hypotheses. The RASA proved to be a very valuable device that can generate suitable results and has the potential to extend the empirical-experimental data

  2. Exploring apposite therapeutic target for apoptosis in filarial parasite: a plausible hypothesis.

    Science.gov (United States)

    Hande, Sneha; Goswami, Kalyan; Jena, Lingaraj; Reddy, Maryada Venkata Rami

    2014-03-01

    Human lymphatic filariasis is a parasitic disease with profound socioeconomic encumbrance owing to its associated disability, affecting predominantly but not limited to the developing nations of tropics and subtropics. There are several technical issues like poor therapeutic and preventive repertoire as well as administrative and infrastructural limitations which jeopardize the salvage measures and further complicate the plight. Therefore, considering the gravity of the problem, WHO has mandated (under tropical disease research scheme) for placing emphasis on validation of novel therapeutic targets against this disease with the unfortunate tag of 'neglected tropical disease'. However, dearth of knowledge of parasite biology viciously coupled with difficulty of access to parasitic material from suitable animal model along with growing cost burden of high end research poses formidable challenge. Based on the recent research evidences, here we propose a premise with targeted apoptotic impact as a novel rationale to be exploited towards anti-parasitic drug development. The new era of bioinformatics ushers in new optimism with a wide range of genomic and proteomic database in public domain. Such platform might offer wonders for drug research, but needs highly selective criterion specificity. In order to test our hypothesis presumptively, we deployed a scheme for identification of target proteins from filarial parasitic origin through wide database search with precise criteria of non-homology against the host along with functional essentiality for the parasite. Further screening for proteins with growth potential from such list of essential non-homologous proteins was undertaken to mine out suitable representative target for ensuing apoptotic impact though effective inhibitors. A unique protein enzyme, RNA dependent RNA polymerase, which besides its vital role in RNA virus is believed to have regulatory role in gene expression, emerged as a plausible target. This protein

  3. Lead-induced SCC of alloy 600 in plausible steam generator crevice environments

    Energy Technology Data Exchange (ETDEWEB)

    Wright, M.D. [Atomic Energy of Canada Limited, Chalk River, Ontario (Canada); Manolescu, A. [Ontario Hydro Technologies, Toronto, Ontario (Canada); Mirzai, M. [Ontario Hydro, Toronto, Ontario (Canada)

    1998-07-01

    Laboratory stress corrosion cracking (SCC) test environments developed to simulate representative BNGS-A steam generator (SG) crevice chemistries have been used to determine the susceptibility of Alloy 600 to lead-induced SCC under plausible SG conditions. Test environments were based on plant SG hideout return data and analysis of removed tubes and deposits. Deviations from the normal near neutral crevice pH environment were considered to simulate possible faulted excursion crevice chemistry and to bound the postulated crevice pH range of 3-9 (at temperature). The effect of lead contamination up to 1000 ppm, but with an emphasis on the 100 to 500 ppm range, was determined. SCC susceptibility was investigated using constant extension rate tensile (CERT) tests and encapsulated C-ring tests. CERT tests were performed at 305 degrees C on tubing representative of BNGS-A SG U-bends. The C-ring test method allowed a wider test matrix covering three temperatures (280, 304 and 315 degrees C), three strain levels (0.2%, 2% and 4%) and tubing representative of U-bends plus tubing given a simulated stress relief to represent material at the tubesheet. The results of this test program confirmed that in the absence of lead contamination, cracking does not occur in these concentrated, 3.3 to 8.9 pH range, crevice environments. Also, it appears that the concentrated crevice environments suppress lead-induced cracking relative to that seen in all-volatile-treatment (AVT) water. For the (static) C-ring tests, lead-induced SCC was only produced in the near-neutral crevice environment and was more severe at 500 ppm than 100 ppm PbO. This trend was also observed in CERT tests but some cracking/grain boundary attack occurred in acidic (pH 3.3) and alkaline (pH 8.9) environments. The C-ring tests indicated that a certain amount of resistance to cracking was imparted by simulated stress relief of the tubing. This heat treatment, confirmed to have resulted in sensitization, promoted

  4. Lead-induced stress-corrosion cracking of alloy 600 in plausible steam generator crevice environments

    Energy Technology Data Exchange (ETDEWEB)

    Wright, M.D. [Atomic Energy of Canada Limited, Chalk River, Ontario (Canada); Manolescu, A. [Ontario Hydro Technologies, Toronto, Ontario (Canada); Mirzai, M. [Ontario Hydro, Toronto, Ontario (Canada)

    1999-03-01

    Laboratory stress-corrosion cracking (SCC) test environments were developed to simulate crevice chemistries representative of Bruce Nuclear Generating Station A (BNPD A) steam generators (SGs); these test environments were used to determine the susceptibility of Alloy 600 to lead-induced SCC under plausible SG conditions. Test environments were based on plant SG hideout return data and analysis of removed tubes and deposits. Deviations from the normal near-neutral crevice pH environment were considered to simulate possible faulted excursion crevice chemistry and to bound the postulated crevice pH range of 3 to 9 (at temperature). The effect of lead contamination up to 1000 ppm, but with an emphasis on the 100- to 500-ppm range, was determined. SCC susceptibility was investigated using constant extension rate tensile (CERT) tests and encapsulated C-ring tests. CERT tests were performed at 305 degrees C on tubing representative of BNPD A SG U-bends. The C-ring test method allowed a wider test matrix, covering 3 temperatures (280 degrees C, 304 degrees C and 315 degrees C), 3 strain levels (0.2%, 2% and 4%), and tubing representative of U-bends plus tubing given a simulated stress relief to represent material at the tube sheet. The results of this test program confirmed that in the absence of lead contamination, cracking does not occur in these concentrated, 3.3 to 8.9 pH range, crevice environments. Also, it appears that the concentrated crevice environments suppress lead-induced cracking relative to that seen in all-volatile-treatment (AVT) water. For the (static) C-ring tests, lead-induced SCC was only produced in the near-neutral crevice environment and was more severe at 500 ppm than at 100 ppm PbO. This trend was also observed in CERT tests, but some cracking-grain boundary attack occurred in acidic (pH 3.3) and alkaline (pH 8.9) environments. The C-ring tests indicated that a certain amount of resistance to cracking was imparted by simulated stress relief of

  5. Nutritional links to plausible mechanisms underlying pancreatic cancer: a conference report.

    Science.gov (United States)

    Hine, R Jean; Srivastava, Sudhir; Milner, John A; Ross, Sharon A

    2003-11-01

    Adenocarcinoma of the pancreas is one of most catastrophic and least understood of cancers. Evidence from clinical studies indicates that the development of pancreas cancer progresses over many years before symptoms appear. Most people with pancreatic cancer die within six months of diagnosis. The lack of early disease markers, the paucity of direct subject/patient interview data and limited availability of high quality biological samples have slowed progress toward identifying environmental and genetic disease risk factors. Much remains to be learned about the development of pancreatic cancer and about potential interventions for disease prevention. Epidemiological and mechanistic studies examining risk factors for pancreatic cancer supply little consistent or strong evidence to provide a cohesive prevention strategy for this cancer, but offer clues for future research concerning the prevention and early detection of this devastating disease. This Executive Summary provides background discussion on pancreatic cancer and summaries of each of the topics discussed at the workshop, including 1) Molecular aspects, 2) Dietary and other risk factors for pancreatic cancer, 3) The metabolic hypothesis for pancreatic cancer, 4) Preclinical studies on pancreatic cancer, 5) Methylation, 6) Oxidative stress and 7) Biomarker Profiling. This document also contains a compilation of recommendations for future research, concluding remarks, a list of speakers and participants attending the workshop, and a selection of key references to aid future research into nutritional links to mechanisms underlying pancreas cancer. The recommendations section suggests gaps in current knowledge and articulates future directions for this area of investigation.

  6. Alternative Energy Sources

    CERN Document Server

    Michaelides, Efstathios E (Stathis)

    2012-01-01

    Alternative Energy Sources is designed to give the reader, a clear view of the role each form of alternative energy may play in supplying the energy needs of the human society in the near and intermediate future (20-50 years).   The two first chapters on energy demand and supply and environmental effects, set the tone as to why the widespread use of alternative energy is essential for the future of human society. The third chapter exposes the reader to the laws of energy conversion processes, as well as the limitations of converting one energy form to another. The sections on exergy give a succinct, quantitative background on the capability/potential of each energy source to produce power on a global scale. The fourth, fifth and sixth chapters are expositions of fission and fusion nuclear energy. The following five chapters (seventh to eleventh) include detailed descriptions of the most common renewable energy sources – wind, solar, geothermal, biomass, hydroelectric – and some of the less common sources...

  7. Is air pollution a plausible candidate for prenatal exposure in autism spectrum disorder (ASD)? : a systematic review / y Dhanashree Vernekar

    OpenAIRE

    Vernekar, Dhanashree

    2013-01-01

    Objective: To present a systematic review of existing literature that investigates biological plausibility of prenatal hazardous air pollutants’ (HAPs) exposure, in the etiology of autism spectrum disorder (ASD) and related outcomes. Method: Electronic databases Pubmed, Biomed Central and National Database for Autism Research, and grey literature pertaining to air pollution association with ASD and related outcomes were searched using specific keywords. The search included 190 HAPs as defi...

  8. Effective Teacher Practice on the Plausibility of Human-Induced Climate Change

    Science.gov (United States)

    Niepold, F.; Sinatra, G. M.; Lombardi, D.

    2013-12-01

    Climate change education programs in the United States seek to promote a deeper understanding of the science of climate change, behavior change and stewardship, and support informed decision making by individuals, organizations, and institutions--all of which are summarized under the term 'climate literacy.' The ultimate goal of climate literacy is to enable actors to address climate change, both in terms of stabilizing and reducing emissions of greenhouse gases, but also an increased capacity to prepare for the consequences and opportunities of climate change. However, the long-term nature of climate change and the required societal response involve the changing students' ideas about controversial scientific issues which presents unique challenges for educators (Lombardi & Sinatra, 2010; Sinatra & Mason, 2008). This session will explore how the United States educational efforts focus on three distinct, but related, areas: the science of climate change, the human-climate interaction, and using climate education to promote informed decision making. Each of these approaches are represented in the Atlas of Science Literacy (American Association for the Advancement of Science, 2007) and in the conceptual framework for science education developed at the National Research Council (NRC) in 2012. Instruction to develop these fundamental thinking skills (e.g., critical evaluation and plausibility reappraisal) has been called for by the Next Generation Science Standards (NGSS) (Achieve, 2013), an innovative and research based way to address climate change education within the decentralized U.S. education system. However, the promise of the NGSS is that students will have more time to build mastery on the subjects, but the form of that instructional practice has been show to be critical. Research has show that effective instructional activities that promote evaluation of evidence improve students' understanding and acceptance toward the scientifically accepted model of human

  9. Plausible antioxidant biomechanics and anticonvulsant pharmacological activity of brain-targeted β-carotene nanoparticles

    Directory of Open Access Journals (Sweden)

    Yusuf M

    2012-08-01

    general tonic–clonic seizures reduced significantly to 2.90 ± 0.98 seconds by the use of BCNP and was further reduced on P-80-BCNP to 1.20 ± 0.20 seconds as compared to PTZ control and PTZ-placebo control (8.09 ± 0.26 seconds. General tonic–clonic seizures latency was increased significantly to 191.0 ± 9.80 seconds in BCNP and was further increased in P-80-BCNP to 231.0 ± 16.30 seconds, as compared to PTZ (120.10 ± 4.50 seconds and placebo control (120.30 ± 7.4 seconds. The results of this study demonstrate a plausible novel anticonvulsant activity of β-carotene at a low dose of 2 mg/kg, with brain-targeted nanodelivery, thus increasing its bioavailability and stability.Keywords: anticonvulsant, blood–brain barrier (BBB, targeted brain delivery, polysorbate-80-coated β-carotene nanoparticles (P-80-BCNP, maximal electroshock seizure (MES, pentylenetetrazole (PTZ

  10. Vulnerabilities to agricultural production shocks: An extreme, plausible scenario for assessment of risk for the insurance sector

    Directory of Open Access Journals (Sweden)

    Tobias Lunt

    2016-01-01

    Full Text Available Climate risks pose a threat to the function of the global food system and therefore also a hazard to the global financial sector, the stability of governments, and the food security and health of the world’s population. This paper presents a method to assess plausible impacts of an agricultural production shock and potential materiality for global insurers. A hypothetical, near-term, plausible, extreme scenario was developed based upon modules of historical agricultural production shocks, linked under a warm phase El Niño-Southern Oscillation (ENSO meteorological framework. The scenario included teleconnected floods and droughts in disparate agricultural production regions around the world, as well as plausible, extreme biotic shocks. In this scenario, global crop yield declines of 10% for maize, 11% for soy, 7% for wheat and 7% for rice result in quadrupled commodity prices and commodity stock fluctuations, civil unrest, significant negative humanitarian consequences and major financial losses worldwide. This work illustrates a need for the scientific community to partner across sectors and industries towards better-integrated global data, modeling and analytical capacities, to better respond to and prepare for concurrent agricultural failure. Governments, humanitarian organizations and the private sector collectively may recognize significant benefits from more systematic assessment of exposure to agricultural climate risk.

  11. Alternative propulsion for automobiles

    CERN Document Server

    Stan, Cornel

    2017-01-01

    The book presents – based on the most recent research and development results worldwide - the perspectives of new propulsion concepts such as electric cars with batteries and fuel cells, and furthermore plug in hybrids with conventional and alternative fuels. The propulsion concepts are evaluated based on specific power, torque characteristic, acceleration behaviour, specific fuel consumption and pollutant emissions. The alternative fuels are discussed in terms of availability, production, technical complexity of the storage on board, costs, safety and infrastructure. The book presents summarized data about vehicles with electric and hybrid propulsion. The propulsion of future cars will be marked by diversity – from compact electric city cars and range extender vehicles for suburban and rural areas up to hybrid or plug in SUV´s, Pick up´s and luxury class automobiles.

  12. Preliminary Study on Plausible Reasoning in Chemistry Teaching of Senior Middle School%高中化学合情推理教学的初步研究

    Institute of Scientific and Technical Information of China (English)

    杨健; 吴俊明; 骆红山

    2009-01-01

    合情推理(Plausible reasoning)对科学教育具重要意义.通过科学哲学、逻辑学讨论以及历史实例说明科学发现离不开合情推理,科学教育必须重视合情推理能力的培养,并对高中化学合情推理教学的可能性、对象和内容等问题进行了讨论.%Plausible reasoning is significant to science education. Scientific philosophy, logic and historical examples prove that plausible reasoning is indispensable to scientific discoveries,so science education must pay attention to the development of plausible reasoning ability of students. Moreover, it discusses the possibility, object and content of plausible reasoning teaching in chemistry of senior middle school.

  13. Alternative Energies

    Energy Technology Data Exchange (ETDEWEB)

    Planting, A.; De saint Jacob, Y.; Verwijs, H.; Belin, H.; Preesman, L.

    2009-03-15

    In two articles, one interview and one column attention is paid to alternative energies. The article 'A new light on saving energy' discusses the option to save energy by modernising lighting systems in urban areas. The column 'View from Paris' focuses on investment decisions in France with regard to renewable energy and energy savings. The article 'Europe turns a blind eye to big battery' discusses developments in batteries to store energy. The interview concerns fuel cell expert and formerly President of UTC Power Jan van Dokkum. The last article gives a brief overview of the European Energy Research Alliance (EERA) and the challenges this alliance will have to face with regard to climate change and energy security.

  14. New Futures, New Pasts

    DEFF Research Database (Denmark)

    Feldt, Jakob Egholm

    2016-01-01

    for all. Nevertheless, Kallen avoided the concept of cosmopolitanism because of the deep controversy over Jews and Jewishness entangled in the history of cosmopolitan thought since the Enlightenment. As an alternative, Kallen re-invented a new Jewish past to suit a future when Jewishness could be a model...

  15. [A disulfiram-alcohol reaction after inhalation of a salbutamol aerosol: a plausible interaction?].

    Science.gov (United States)

    Choi, T; Neven, A; Al Hadithy, A F Y

    2016-01-01

    An asthmatic patient (male, aged 47) being treated for his alcohol dependence complained of experiencing mild symptoms of disulfiram-alcohol reaction after using of pressurised metered-dose inhaler containing ethanol. It has been reported in the literature that the disulfiram-alcohol reaction may occur after a patient has been exposed to only minimal amounts of ethanol. This is why, in daily practice, physicians are generally reluctant to prescribe preparations containing ethanol and why they usually switch patients to an alternative. However, close evaluation of the biopharmaceutical and pharmacokinetic aspects of ethanol suggests that subjective disulfiram-alcohol reactions following the use of inhalers containing ethanol cannot be explained rationally from a clinical pharmacological perspective.

  16. A plausible worst-case scenario of increasing multidrug resistance as a tool for assessing societal risks and capabilities in Sweden.

    Science.gov (United States)

    Roffey, Roger; Lindberg, Anna; Molin, Lena; Wikman-Svahn, Per

    2015-01-01

    A "plausible worst-case scenario" of a gradually increasing level of multidrug-resistant bacteria (carbapenem-resistant E. coli) in the human population was developed and used to study how Swedish authorities would manage this situation and to identify preventive measures that could be taken. Key findings include: (1) a scenario in which 5% of the population in southern Sweden become carriers of carbapenem-resistant E. coli is possible or even likely in 10 to 15 years; (2) it is not clear when and how the increase of E. coli resistant to carbapenems as in the scenario would be detected in the general human population; (3) identified negative consequences of the scenario on society were primarily due to increased demands on the healthcare system and potential consequences for food-producing animals, food safety, and environmental health; and (4) a number of preventive and mitigation measures were suggested, including initiating long-term screening programs for public and animal health as well as for food and water production to monitor increasing levels of carbapenem resistance. Strategies and plans to prevent and handle future increasing prevalence of multidrug-resistant bacteria need to be developed.

  17. Plausible Speech Translation in Literature%论文学作品中似是而非的辞格翻译

    Institute of Scientific and Technical Information of China (English)

    廖巧云

    2011-01-01

    辞格是一种语言变体,是各种语言共有的现象。由于各种原因,辞格的误译现象在翻译活动中并不鲜见。然而,辞格误译却有很大一部分呈现出似是而非的特征。辞格中似是而非的翻译,表面看来完全正确,并且在两种语言中具有形式上完全对等的特征,这使得它们更容易被译文读者接受,使其无意识中被迫接受错误信息。本文借用奈达的翻译功能对等理论,通过对文学作品中出现的似是而非的辞格译文进行案例分析,从而尽可能地为译者在今后的辞格翻译活动提供借鉴,减少辞格翻译中似是而非的现象。%Speech is a language variant,is the common phenomenon to all languages.For various reasons,the phenomenon of a mistranslation of speech activities in the translation is not uncommon.However,there is a huge misinterpretation of speech as part of showing a paradoxical character.Speech translation in the paradoxical,seemingly completely correct,and in the two languages have formal characteristics of full reciprocity,which makes them more likely to be asked readers to accept,it was forced to accept the error message unconscious.This paper uses Nida's translation functional equivalence theory,through the literary works that ap-pear plausible case analysis of the translation of speech,which as much as possible for the translators in the future of speech trans-lation activities provide a reference,to reduce the plausible translation of speech phenomenon.

  18. Towards an Alternative Educational Technology.

    Science.gov (United States)

    Mansfield, Roger; Nunan, E. E.

    1978-01-01

    Outlines an alternative form of educational technology based on an analysis of criticism levelled at the subject, both from within and without. Article contends that the future of educational technology rests on an expansion of its concerns, rather than a refinement or modification of its existing content. (Author)

  19. A Note on Unified Statistics Including Fermi-Dirac, Bose-Einstein, and Tsallis Statistics, and Plausible Extension to Anisotropic Effect

    Directory of Open Access Journals (Sweden)

    Christianto V.

    2007-04-01

    Full Text Available In the light of some recent hypotheses suggesting plausible unification of thermostatistics where Fermi-Dirac, Bose-Einstein and Tsallis statistics become its special subsets, we consider further plausible extension to include non-integer Hausdorff dimension, which becomes realization of fractal entropy concept. In the subsequent section, we also discuss plausible extension of this unified statistics to include anisotropic effect by using quaternion oscillator, which may be observed in the context of Cosmic Microwave Background Radiation. Further observation is of course recommended in order to refute or verify this proposition.

  20. Episodic future thinking in generalized anxiety disorder.

    Science.gov (United States)

    Wu, Jade Q; Szpunar, Karl K; Godovich, Sheina A; Schacter, Daniel L; Hofmann, Stefan G

    2015-12-01

    Research on future-oriented cognition in generalized anxiety disorder (GAD) has primarily focused on worry, while less is known about the role of episodic future thinking (EFT), an imagery-based cognitive process. To characterize EFT in this disorder, we used the experimental recombination procedure, in which 21 GAD and 19 healthy participants simulated positive, neutral and negative novel future events either once or repeatedly, and rated their phenomenological experience of EFT. Results showed that healthy controls spontaneously generated more detailed EFT over repeated simulations. Both groups found EFT easier to generate after repeated simulations, except when GAD participants simulated positive events. They also perceived higher plausibility of negative-not positive or neutral-future events than did controls. These results demonstrate a negativity bias in GAD individuals' episodic future cognition, and suggest their relative deficit in generating vivid EFT. We discuss implications for the theory and treatment of GAD.

  1. Future Contingents

    DEFF Research Database (Denmark)

    Øhrstrøm, Peter; Hasle., Per F. V.

    2015-01-01

    will be a sea-battle tomorrow” could serve as standard examples. What could be called the problem of future contingents concerns how to ascribe truth-values to such statements. If there are several possible decisions out of which one is going to be made freely tomorrow, can there be a truth now about which one......, ‘future contingents’ could also refer to future contingent objects. A statement like “The first astronaut to go to Mars will have a unique experience” could be analyzed as referring to an object not yet existing, supposing that one day in the distant future some person will indeed travel to Mars......, but that person has not yet been born. The notion of ‘future contingent objects’ involves important philosophical questions, for instance the issue of ethical obligations towards future generations, quantification over ‘future contingent objects’ etc. However, this entry is confined to the study of future...

  2. Future Contingents

    DEFF Research Database (Denmark)

    Øhrstrøm, Peter; Hasle., Per F. V.

    2011-01-01

    will be a sea-battle tomorrow” could serve as standard examples. What could be called the problem of future contingents concerns how to ascribe truth-values to such statements. If there are several possible decisions out of which one is going to be made freely tomorrow, can there be a truth now about which one......, ‘future contingents’ could also refer to future contingent objects. A statement like “The first astronaut to go to Mars will have a unique experience” could be analyzed as referring to an object not yet existing, supposing that one day in the distant future some person will indeed travel to Mars......, but that person has not yet been born. The notion of ‘future contingent objects’ involves important philosophical questions, for instance the issue of ethical obligations towards future generations, quantification over ‘future contingent objects’ etc. However, this entry is confined to the study of future...

  3. Future accelerators (?)

    Energy Technology Data Exchange (ETDEWEB)

    John Womersley

    2003-08-21

    I describe the future accelerator facilities that are currently foreseen for electroweak scale physics, neutrino physics, and nuclear structure. I will explore the physics justification for these machines, and suggest how the case for future accelerators can be made.

  4. A plausible link between the asteroid 21 Lutetia and CH carbonaceous chondrites

    Science.gov (United States)

    Moyano-Cambero, Carles E.; Trigo-Rodríguez, Josep M.; Llorca, Jordi; Fornasier, Sonia; Barucci, Maria A.; Rimola, Albert

    2016-10-01

    A crucial topic in planetology research is establishing links between primitive meteorites and their parent asteroids. In this study, we investigate the feasibility of a connection between asteroids similar to 21 Lutetia, encountered by the Rosetta mission in July 2010, and the CH3 carbonaceous chondrite Pecora Escarpment 91467 (PCA 91467). Several spectra of this meteorite were acquired in the ultraviolet to near-infrared (0.3-2.2 μm) and in the midinfrared to thermal infrared (2.5-30.0 μm or 4000 to 333 cm-1), and they are compared here to spectra from the asteroid 21 Lutetia. There are several similarities in absorption bands and overall spectral behavior between this CH3 meteorite and 21 Lutetia. Considering also that the bulk density of Lutetia is similar to that of CH chondrites, we suggest that this asteroid could be similar, or related to, the parent body of these meteorites, if not the parent body itself. However, the apparent surface diversity of Lutetia pointed out in previous studies indicates that it could simultaneously be related to other types of chondrites. Future discovery of additional unweathered CH chondrites could provide deeper insight in the possible connection between this family of metal-rich carbonaceous chondrites and 21 Lutetia or other featureless, possibly hydrated high-albedo asteroids.

  5. Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota

    Directory of Open Access Journals (Sweden)

    Charlotte Madore

    2016-01-01

    Full Text Available Several genetic causes of autism spectrum disorder (ASD have been identified. However, more recent work has highlighted that certain environmental exposures early in life may also account for some cases of autism. Environmental insults during pregnancy, such as infection or malnutrition, seem to dramatically impact brain development. Maternal viral or bacterial infections have been characterized as disruptors of brain shaping, even if their underlying mechanisms are not yet fully understood. Poor nutritional diversity, as well as nutrient deficiency, is strongly associated with neurodevelopmental disorders in children. For instance, imbalanced levels of essential fatty acids, and especially polyunsaturated fatty acids (PUFAs, are observed in patients with ASD and other neurodevelopmental disorders (e.g., attention deficit hyperactivity disorder (ADHD and schizophrenia. Interestingly, PUFAs, and specifically n-3 PUFAs, are powerful immunomodulators that exert anti-inflammatory properties. These prenatal dietary and immunologic factors not only impact the fetal brain, but also affect the microbiota. Recent work suggests that the microbiota could be the missing link between environmental insults in prenatal life and future neurodevelopmental disorders. As both nutrition and inflammation can massively affect the microbiota, we discuss here how understanding the crosstalk between these three actors could provide a promising framework to better elucidate ASD etiology.

  6. Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota

    Science.gov (United States)

    Madore, Charlotte; Leyrolle, Quentin; Lacabanne, Chloé; Benmamar-Badel, Anouk; Joffre, Corinne; Nadjar, Agnes

    2016-01-01

    Several genetic causes of autism spectrum disorder (ASD) have been identified. However, more recent work has highlighted that certain environmental exposures early in life may also account for some cases of autism. Environmental insults during pregnancy, such as infection or malnutrition, seem to dramatically impact brain development. Maternal viral or bacterial infections have been characterized as disruptors of brain shaping, even if their underlying mechanisms are not yet fully understood. Poor nutritional diversity, as well as nutrient deficiency, is strongly associated with neurodevelopmental disorders in children. For instance, imbalanced levels of essential fatty acids, and especially polyunsaturated fatty acids (PUFAs), are observed in patients with ASD and other neurodevelopmental disorders (e.g., attention deficit hyperactivity disorder (ADHD) and schizophrenia). Interestingly, PUFAs, and specifically n-3 PUFAs, are powerful immunomodulators that exert anti-inflammatory properties. These prenatal dietary and immunologic factors not only impact the fetal brain, but also affect the microbiota. Recent work suggests that the microbiota could be the missing link between environmental insults in prenatal life and future neurodevelopmental disorders. As both nutrition and inflammation can massively affect the microbiota, we discuss here how understanding the crosstalk between these three actors could provide a promising framework to better elucidate ASD etiology. PMID:27840741

  7. Exploring plausible formation scenarios for the planet candidate orbiting Proxima Centauri

    CERN Document Server

    Coleman, Gavin A L; Paardekooper, Sijme-Jan; Dreizler, Stefan; Giesers, Benjamin; Anglada-Escude, Guillem

    2016-01-01

    We present a study of 4 different formation scenarios that may explain the origin of the recently announced planet `Proxima b' orbiting the star Proxima Centauri. The aim is to examine how the formation scenarios differ in their predictions for the multiplicity of the Proxima planetary system, the water/volatile content of Proxima b and its eccentricity, so that these can be tested by future observations. A scenario of in situ formation via giant impacts from a locally enhanced disc of planetary embryos and planetesimals, predicts that Proxima b will be a member of a multiplanet system with a measurably finite value of orbital eccentricity. Assuming that the local solid enhancement needed to form a Proxima b analogue with a minimum mass of 1.3 Earth masses arises because of the inwards drift of solids in the form of small planetesimals/boulders, this scenario also likely results in Proxima b analogues that are moderately endowed with water/volatiles, arising from the dynamical diffusion of icy planetesimals f...

  8. Neuroinflammation in Autism: Plausible Role of Maternal Inflammation, Dietary Omega 3, and Microbiota.

    Science.gov (United States)

    Madore, Charlotte; Leyrolle, Quentin; Lacabanne, Chloé; Benmamar-Badel, Anouk; Joffre, Corinne; Nadjar, Agnes; Layé, Sophie

    2016-01-01

    Several genetic causes of autism spectrum disorder (ASD) have been identified. However, more recent work has highlighted that certain environmental exposures early in life may also account for some cases of autism. Environmental insults during pregnancy, such as infection or malnutrition, seem to dramatically impact brain development. Maternal viral or bacterial infections have been characterized as disruptors of brain shaping, even if their underlying mechanisms are not yet fully understood. Poor nutritional diversity, as well as nutrient deficiency, is strongly associated with neurodevelopmental disorders in children. For instance, imbalanced levels of essential fatty acids, and especially polyunsaturated fatty acids (PUFAs), are observed in patients with ASD and other neurodevelopmental disorders (e.g., attention deficit hyperactivity disorder (ADHD) and schizophrenia). Interestingly, PUFAs, and specifically n-3 PUFAs, are powerful immunomodulators that exert anti-inflammatory properties. These prenatal dietary and immunologic factors not only impact the fetal brain, but also affect the microbiota. Recent work suggests that the microbiota could be the missing link between environmental insults in prenatal life and future neurodevelopmental disorders. As both nutrition and inflammation can massively affect the microbiota, we discuss here how understanding the crosstalk between these three actors could provide a promising framework to better elucidate ASD etiology.

  9. Hapten-Induced Contact Hypersensitivity, Autoimmune Reactions, and Tumor Regression: Plausibility of Mediating Antitumor Immunity

    Directory of Open Access Journals (Sweden)

    Dan A. Erkes

    2014-01-01

    Full Text Available Haptens are small molecule irritants that bind to proteins and elicit an immune response. Haptens have been commonly used to study allergic contact dermatitis (ACD using animal contact hypersensitivity (CHS models. However, extensive research into contact hypersensitivity has offered a confusing and intriguing mechanism of allergic reactions occurring in the skin. The abilities of haptens to induce such reactions have been frequently utilized to study the mechanisms of inflammatory bowel disease (IBD to induce autoimmune-like responses such as autoimmune hemolytic anemia and to elicit viral wart and tumor regression. Hapten-induced tumor regression has been studied since the mid-1900s and relies on four major concepts: (1 ex vivo haptenation, (2 in situ haptenation, (3 epifocal hapten application, and (4 antigen-hapten conjugate injection. Each of these approaches elicits unique responses in mice and humans. The present review attempts to provide a critical appraisal of the hapten-mediated tumor treatments and offers insights for future development of the field.

  10. Tandem synthesis of alternating polyesters from renewable resources.

    Science.gov (United States)

    Robert, Carine; de Montigny, Frédéric; Thomas, Christophe M

    2011-12-13

    The vast majority of commodity materials are obtained from petrochemical feedstocks. These resources will plausibly be depleted within the next 100 years, and the peak in global oil production is estimated to occur within the next few decades. In this regard, biomass represents an abundant carbon-neutral renewable resource for the production of polymers. Here we report a new strategy, based on tandem catalysis, to obtain renewable materials. Commercially available complexes are found to be efficient catalysts for alternating polyesters from the cyclization of dicarboxylic acids followed by alternating copolymerization of the resulting anhydrides with epoxides. This operationally simple method is an attractive strategy for the production of new biodegradable polyesters.

  11. Education for an Interdependent Future.

    Science.gov (United States)

    Brodbelt, Samuel

    1979-01-01

    Calls for social studies teachers to emphasize future studies and the implications of growing global interdependence. Students should learn about alternative futures, the possible decline of nationalism, overpopulation and food resources, the ecological system and natural resources, and ways of achieving interdependence. (AV)

  12. Education for an Interdependent Future.

    Science.gov (United States)

    Brodbelt, Samuel

    1979-01-01

    Calls for social studies teachers to emphasize future studies and the implications of growing global interdependence. Students should learn about alternative futures, the possible decline of nationalism, overpopulation and food resources, the ecological system and natural resources, and ways of achieving interdependence. (AV)

  13. Looking for an Alternative.

    Science.gov (United States)

    Kennedy, Jack

    1999-01-01

    Argues that high school newspapers might do well to create stronger ties with alternative weeklies. Discusses issues of niche marketing, alternative content, and alternative presentation. Notes that high school papers could learn a lot from alternative newspapers. (SR)

  14. Ionic liquid pretreatment of biomass for sugars production: Driving factors with a plausible mechanism for higher enzymatic digestibility.

    Science.gov (United States)

    Raj, Tirath; Gaur, Ruchi; Dixit, Pooja; Gupta, Ravi P; Kagdiyal, V; Kumar, Ravindra; Tuli, Deepak K

    2016-09-20

    In this study, five ionic liquids (ILs) have been explored for biomass pretreatment for the production of fermentable sugar. We also investigated the driving factors responsible for improved enzymatic digestibility of various ILs treated biomass along with postulating the plausible mechanism thereof. Post pretreatment, mainly two factors impacted the enzymatic digestibility (i) structural deformation (cellulose I to II) along with xylan/lignin removal and (ii) properties of ILs; wherein, K-T parameters, viscosity and surface tension had a direct influence on pretreatment. A systematic investigation of these parameters and their impact on enzymatic digestibility is drawn. [C2mim][OAc] with β-value 1.32 resulted 97.7% of glucose yield using 10 FPU/g of biomass. A closer insight into the cellulose structural transformation has prompted a plausible mechanism explaining the better digestibility. The impact of these parameters on the digestibility can pave the way to customize the process to make biomass vulnerable to enzymatic attack.

  15. Antimicrobial drug use in Austrian pig farms: plausibility check of electronic on-farm records and estimation of consumption.

    Science.gov (United States)

    Trauffler, M; Griesbacher, A; Fuchs, K; Köfer, J

    2014-10-25

    Electronic drug application records from farmers from 75 conventional pig farms were revised and checked for their plausibility. The registered drug amounts were verified by comparing the farmers' records with veterinarians' dispensary records. The antimicrobial consumption was evaluated from 2008 to 2011 and expressed in weight of active substance(s), number of used daily doses (nUDD), number of animal daily doses (nADD) and number of product-related daily doses (nPrDD). All results were referred to one year and animal bodyweight (kg biomass). The data plausibility proof revealed about 14 per cent of unrealistic drug amount entries in the farmers' records. The annual antimicrobial consumption was 33.9 mg/kg/year, 4.9 UDDkg/kg/year, 1.9 ADDkg/kg/year and 2.5 PrDDkg/kg/year (average). Most of the antimicrobials were applied orally (86 per cent) and at group-level. Main therapy indications were metaphylactic/prophylactic measures (farrow-to-finish and fattening farms) or digestive tract diseases (breeding farms). The proportion of the 'highest priority critically important antimicrobials' was low (12 per cent). After determination of a threshold value, farms with a high antimicrobial use could be detected. Statistical tests showed that the veterinarian had an influence on the dosage, the therapy indication and the active substance. Orally administered antimicrobials were mostly underdosed, parenterally administered antimicrobials rather correctly or overdosed.

  16. Plausibility, necessity and identity: A logic of relative plausibility%似然性、必然性和恒等:一种相对似然性逻辑

    Institute of Scientific and Technical Information of China (English)

    李小五; 文学锋

    2007-01-01

    构造一个希尔伯特型的系统RPL, 来刻画由J·哈尔彭提出的似然性测度概念, 证明RPL相对一个邻域型语义是可靠和完全的.运用表述RPL的语言, 证明它可以定义已经得到深入研究的必然性、条件句和命题恒等这样的概念.%We construct a Hilbert style system RPL for the notion of plausibility measure introduced by Halpern J, and we prove the soundness and completeness with respect to a neighborhood style semantics.Using the language of RPL, we demonstrate that it can define well-studied notions of necessity,conditionals and propositional identity.

  17. Overview of alternative sources in the Brazilian electric matrix: incentive policies, the current market and future prospects; Panorama das fontes alternativas na matriz eletrica brasileira: politicas de incentivo, mercado atual e perspectivas futuras

    Energy Technology Data Exchange (ETDEWEB)

    Nogueira, Larissa Goncalves; Dedecca, Joao Gorestein; Jannuzzi, Gilberto de Martinno [Universidade Estadual de Campinas (UNICAMP), SP (Brazil). Fac. de Engenharia Mecanica; Gomes, Rodolfo Dourado [International Energy Initiative (IEI), Campinas, SP (Brazil)

    2010-07-01

    The Brazilian power matrix is among the cleanest in the world due to the large share of hydroelectric generation. In recent years, several efforts have been concentrated in an attempt to diversify the matrix from the insertion of other renewable alternatives sources. The aim of this study is to analyze the state of generation through biomass, wind and small hydropower sources, covered by specific auctions and the Proinfa, and solar energy (photovoltaic and thermal high temperature) in Brazil, besides trends development of these generation sources. (author)

  18. SPECTRAL VARIATIONS OF THE SKY: CONSTRAINTS ON ALTERNATE UNIVERSES

    Energy Technology Data Exchange (ETDEWEB)

    Chary, R., E-mail: rchary@caltech.edu [Infrared Processing and Analysis Center, MS314-6, California Institute of Technology, Pasadena, CA 91125 (United States)

    2016-01-20

    The fine tuning of parameters required to reproduce our present day universe suggests that our universe may simply be a region within an eternally inflating super-region. Many other regions beyond our observable universe would exist with each such region governed by a different set of physical parameters. Collision between these regions, if they occur, should leave signatures of anisotropy in the cosmic microwave background (CMB) but have not been seen. We analyze the spectral properties of masked, foreground-cleaned maps between 100 and 545 GHz constructed from the Planck data set. Four distinct ∼2°–4° regions associated with CMB cold spots show anomalously strong 143 GHz emission but no correspondingly strong emission at either 100 or 217 GHz. The signal to noise of this 143 GHz residual emission is at the ≳6σ level which reduces to 3.2–5.4σ after subtraction of remaining synchrotron/free–free foregrounds. We assess different mechanisms for this residual emission and conclude that although there is a 30% probability that noise fluctuations may cause foregrounds to fall within 3σ of the excess, there is less than a 0.5% probability that foregrounds can explain all the excess. A plausible explanation is that the collision of our universe with an alternate universe whose baryon to photon ratio is a factor of ∼4500 larger than ours, could produce enhanced hydrogen Paschen-series emission at the epoch of recombination. Future spectral mapping and deeper observations at 100 and 217 GHz are needed to mitigate systematics arising from unknown Galactic foregrounds and to confirm this unusual hypothesis.

  19. Alternatives to prison sentences : Experiences and development

    NARCIS (Netherlands)

    Junger-Tas, J.

    1994-01-01

    This study presents an overview of experiences with alternative sanctions in other countries with a view to the future development of the Dutch sanctioning system. The principal objective of the study was to examine the use of alternatives to prison with respect to their effectiveness and efficiency

  20. Future aviation fuels overview

    Science.gov (United States)

    Reck, G. M.

    1980-01-01

    The outlook for aviation fuels through the turn of the century is briefly discussed and the general objectives of the NASA Lewis Alternative Aviation Fuels Research Project are outlined. The NASA program involves the evaluation of potential characteristics of future jet aircraft fuels, the determination of the effects of those fuels on engine and fuel system components, and the development of a component technology to use those fuels.

  1. The faulty statistics of complementary alternative medicine (CAM).

    Science.gov (United States)

    Pandolfi, Maurizio; Carreras, Giulia

    2014-09-01

    The authors illustrate the difficulties involved in obtaining a valid statistical significance in clinical studies especially when the prior probability of the hypothesis under scrutiny is low. Since the prior probability of a research hypothesis is directly related to its scientific plausibility, the commonly used frequentist statistics, which does not take into account this probability, is particularly unsuitable for studies exploring matters in various degree disconnected from science such as complementary alternative medicine (CAM) interventions. Any statistical significance obtained in this field should be considered with great caution and may be better applied to more plausible hypotheses (like placebo effect) than that examined - which usually is the specific efficacy of the intervention. Since achieving meaningful statistical significance is an essential step in the validation of medical interventions, CAM practices, producing only outcomes inherently resistant to statistical validation, appear not to belong to modern evidence-based medicine.

  2. Climate Change Impacts on Agriculture and Food Security in 2050 under a Range of Plausible Socioeconomic and Emissions Scenarios

    Science.gov (United States)

    Wiebe, K.; Lotze-Campen, H.; Bodirsky, B.; Kavallari, A.; Mason-d'Croz, D.; van der Mensbrugghe, D.; Robinson, S.; Sands, R.; Tabeau, A.; Willenbockel, D.; Islam, S.; van Meijl, H.; Mueller, C.; Robertson, R.

    2014-12-01

    Previous studies have combined climate, crop and economic models to examine the impact of climate change on agricultural production and food security, but results have varied widely due to differences in models, scenarios and data. Recent work has examined (and narrowed) these differences through systematic model intercomparison using a high-emissions pathway to highlight the differences. New work extends that analysis to cover a range of plausible socioeconomic scenarios and emission pathways. Results from three general circulation models are combined with one crop model and five global economic models to examine the global and regional impacts of climate change on yields, area, production, prices and trade for coarse grains, rice, wheat, oilseeds and sugar to 2050. Results show that yield impacts vary with changes in population, income and technology as well as emissions, but are reduced in all cases by endogenous changes in prices and other variables.

  3. Gene-ontology enrichment analysis in two independent family-based samples highlights biologically plausible processes for autism spectrum disorders.

    LENUS (Irish Health Repository)

    Anney, Richard J L

    2012-02-01

    Recent genome-wide association studies (GWAS) have implicated a range of genes from discrete biological pathways in the aetiology of autism. However, despite the strong influence of genetic factors, association studies have yet to identify statistically robust, replicated major effect genes or SNPs. We apply the principle of the SNP ratio test methodology described by O\\'Dushlaine et al to over 2100 families from the Autism Genome Project (AGP). Using a two-stage design we examine association enrichment in 5955 unique gene-ontology classifications across four groupings based on two phenotypic and two ancestral classifications. Based on estimates from simulation we identify excess of association enrichment across all analyses. We observe enrichment in association for sets of genes involved in diverse biological processes, including pyruvate metabolism, transcription factor activation, cell-signalling and cell-cycle regulation. Both genes and processes that show enrichment have previously been examined in autistic disorders and offer biologically plausibility to these findings.

  4. The role of adverse childhood experiences in cardiovascular disease risk: a review with emphasis on plausible mechanisms.

    Science.gov (United States)

    Su, Shaoyong; Jimenez, Marcia P; Roberts, Cole T F; Loucks, Eric B

    2015-10-01

    Childhood adversity, characterized by abuse, neglect, and household dysfunction, is a problem that exerts a significant impact on individuals, families, and society. Growing evidence suggests that adverse childhood experiences (ACEs) are associated with health decline in adulthood, including cardiovascular disease (CVD). In the current review, we first provide an overview of the association between ACEs and CVD risk, with updates on the latest epidemiological evidence. Second, we briefly review plausible pathways by which ACEs could influence CVD risk, including traditional risk factors and novel mechanisms. Finally, we highlight the potential implications of ACEs in clinical and public health. Information gleaned from this review should help physicians and researchers in better understanding potential long-term consequences of ACEs and considering adapting current strategies in treatment or intervention for patients with ACEs.

  5. Influence of the Aqueous Environment on Protein Structure—A Plausible Hypothesis Concerning the Mechanism of Amyloidogenesis

    Directory of Open Access Journals (Sweden)

    Irena Roterman

    2016-09-01

    Full Text Available The aqueous environment is a pervasive factor which, in many ways, determines the protein folding process and consequently the activity of proteins. Proteins are unable to perform their function unless immersed in water (membrane proteins excluded from this statement. Tertiary conformational stabilization is dependent on the presence of internal force fields (nonbonding interactions between atoms, as well as an external force field generated by water. The hitherto the unknown structuralization of water as the aqueous environment may be elucidated by analyzing its effects on protein structure and function. Our study is based on the fuzzy oil drop model—a mechanism which describes the formation of a hydrophobic core and attempts to explain the emergence of amyloid-like fibrils. A set of proteins which vary with respect to their fuzzy oil drop status (including titin, transthyretin and a prion protein have been selected for in-depth analysis to suggest the plausible mechanism of amyloidogenesis.

  6. Plausibility of the implausible: is it possible that ultra-high dilutions ‘without biological activity’ cause adverse effects?

    Directory of Open Access Journals (Sweden)

    Marcus Zulian Teixeira

    2013-06-01

    .7% of cases the potencies were described as below of the 12ª Centesimal, the point beyond which the likelihood of a single molecule being present in the remedy approaches zero”, the authors claim that “in the majority of cases, the possible mechanism of action involved allergic reactions or ingestion of toxic substances”. With this approach, the authors seek to dismiss the biological effects of ultra-high dilutions, because if they cause AEs would be confirming the plausibility of its possible therapeutic effects. However, toxicological tests are required to affirm that AEs are a consequence of toxic (allergic effects of the substances or of ‘imponderable’ effects of ultra-high dilutions. In view of the recent report cited in the review [12] in which a complex homeopathic medicine indicated for treating infant colic (Gali-col Baby, GCB caused apparent life-threatening events (ALTEs were described by the National Institutes of Health consensus group in 1986 as “an episode that is frightening to the observer and that is characterized by some combination of apnea (central or occasionally obstructive, color change (usually cyanotic or pallid but occasionally erythematous or plethoric, a marked change in muscle tone (usually marked limpness, choking or gagging” [13] in consequence of the ‘toxicity of active ingredients’ (Citrullus colocynthis, Matricaria chamomilla, Bryonia alba, Nux vomica, Veratrum album, Magnesia phosphorica and Cuprum metallicum at potencies between 4C and 5C, Oberbaum et al. [14] performed a toxicological study of these components showing that “doses ingested in the GCB series were 10-13 orders of magnitude smaller than those reported to cause toxic reactions in humans” and that “there was poor correlation between symptoms with GCB and toxic profiles of the components”. As alternative explanation, they suggest that “four components (Veratrum album, Cuprum metallicum, Bryonia alba and Matricaria chamomilla have an

  7. How robust is a robust policy? A comparative analysis of alternative robustness metrics for supporting robust decision analysis.

    Science.gov (United States)

    Kwakkel, Jan; Haasnoot, Marjolijn

    2015-04-01

    In response to climate and socio-economic change, in various policy domains there is increasingly a call for robust plans or policies. That is, plans or policies that performs well in a very large range of plausible futures. In the literature, a wide range of alternative robustness metrics can be found. The relative merit of these alternative conceptualizations of robustness has, however, received less attention. Evidently, different robustness metrics can result in different plans or policies being adopted. This paper investigates the consequences of several robustness metrics on decision making, illustrated here by the design of a flood risk management plan. A fictitious case, inspired by a river reach in the Netherlands is used. The performance of this system in terms of casualties, damages, and costs for flood and damage mitigation actions is explored using a time horizon of 100 years, and accounting for uncertainties pertaining to climate change and land use change. A set of candidate policy options is specified up front. This set of options includes dike raising, dike strengthening, creating more space for the river, and flood proof building and evacuation options. The overarching aim is to design an effective flood risk mitigation strategy that is designed from the outset to be adapted over time in response to how the future actually unfolds. To this end, the plan will be based on the dynamic adaptive policy pathway approach (Haasnoot, Kwakkel et al. 2013) being used in the Dutch Delta Program. The policy problem is formulated as a multi-objective robust optimization problem (Kwakkel, Haasnoot et al. 2014). We solve the multi-objective robust optimization problem using several alternative robustness metrics, including both satisficing robustness metrics and regret based robustness metrics. Satisficing robustness metrics focus on the performance of candidate plans across a large ensemble of plausible futures. Regret based robustness metrics compare the

  8. Future Textiles

    DEFF Research Database (Denmark)

    Hansen, Anne-Louise Degn; Jensen, Hanne Troels Fusvad; Hansen, Martin

    2011-01-01

    Magasinet Future Textiles samler resultaterne fra projektet Future Textiles, der markedsfører området intelligente tekstiler. I magasinet kan man læse om trends, drivkræfter, udfordringer samt få ideer til nye produkter inden for intelligente tekstiler. Områder som bæredygtighed og kundetilpasning...

  9. Hospital diversification: evaluating alternatives.

    Science.gov (United States)

    Hammer, L

    1987-05-01

    The appropriateness of diversification as a growth strategy for hospitals is discussed, and planning for diversification is described. Because new forms of health-care delivery are now in direct competition with hospitals, many hospitals are confronting environmental pressures and preparing for future survival through diversification. To explore the potential risks and benefits of diversification, the hospital must identify opportunities for new business ventures. Diversification can be "related," through an expansion of the primary product line (health care), or "unrelated," into areas not directly associated with health care. The hospital must establish specific criteria for evaluating each diversification alternative, and the two or three most attractive options should be analyzed further through a financial feasibility study. The hospital should also seek legal advice to determine the implications of diversification for maintenance of tax status, antitrust limitations, and applicability of certificate of need. Although diversification may not be appropriate for every institution, hospitals should consider it as a strategy for increasing their revenue base, confronting environmental pressures, and securing future survival.

  10. Future Climate Analysis

    Energy Technology Data Exchange (ETDEWEB)

    C. G. Cambell

    2004-09-03

    This report documents an analysis that was performed to estimate climatic variables for the next 10,000 years by forecasting the timing and nature of climate change at Yucca Mountain, Nevada, the site of a repository for spent nuclear fuel and high-level radioactive waste. The future-climate estimates are based on an analysis of past-climate data from analog meteorological stations, and this report provides the rationale for the selection of these analog stations. The stations selected provide an upper and a lower climate bound for each future climate, and the data from those sites will provide input to the following reports: ''Simulation of Net Infiltration for Present-Day and Potential Future Climates'' (BSC 2004 [DIRS 170007]), ''Total System Performance Assessment (TSPA) Model/Analysis for the License Application'' (BSC 2004 [DIRS 168504]), ''Features, Events, and Processes in UZ Flow and Transport'' (BSC 2004 [DIRS 170012]), and ''Features, Events, and Processes in SZ Flow and Transport'' (BSC 2004 [DIRS 170013]). Forecasting long-term future climates, especially for the next 10,000 years, is highly speculative and rarely attempted. A very limited literature exists concerning the subject, largely from the British radioactive waste disposal effort. The discussion presented here is one available forecasting method for establishing upper and lower bounds for future climate estimates. The selection of different methods is directly dependent on the available evidence used to build a forecasting argument. The method used here involves selecting a particular past climate from many past climates, as an analog for future climate. While alternative analyses are possible for the case presented for Yucca Mountain, the evidence (data) used would be the same and the conclusions would not be expected to drastically change. Other studies might develop a different rationale or select other past

  11. Modeling future water demand in California from developed and agricultural land uses

    Science.gov (United States)

    Wilson, T. S.; Sleeter, B. M.; Cameron, D. R.

    2015-12-01

    Municipal and urban land-use intensification in coming decades will place increasing pressure on water resources in California. The state is currently experiencing one of the most extreme droughts on record. This coupled with earlier spring snowmelt and projected future climate warming will increasingly constrain already limited water supplies. The development of spatially explicit models of future land use driven by empirical, historical land use change data allow exploration of plausible LULC-related water demand futures and potential mitigation strategies. We utilized the Land Use and Carbon Scenario Simulator (LUCAS) state-and-transition simulation model to project spatially explicit (1 km) future developed and agricultural land use from 2012 to 2062 and estimated the associated water use for California's Mediterranean ecoregions. We modeled 100 Monte Carlo simulations to better characterize and project historical land-use change variability. Under current efficiency rates, total water demand was projected to increase 15.1% by 2062, driven primarily by increases in urbanization and shifts to more water intensive crops. Developed land use was projected to increase by 89.8%-97.2% and result in an average 85.9% increase in municipal water use, while agricultural water use was projected to decline by approximately 3.9%, driven by decreases in row crops and increases in woody cropland. In order for water demand in 2062 to balance to current demand levels, the currently mandated 25% reduction in urban water use must remain in place in conjunction with a near 7% reduction in agricultural water use. Scenarios of land-use related water demand are useful for visualizing alternative futures, examining potential management approaches, and enabling better informed resource management decisions.

  12. Future generations in democracy

    DEFF Research Database (Denmark)

    Jensen, Karsten Klint

    2015-01-01

    This paper asks whether the genuine representation of future generations brings any added value that could not be achieved by institutions or procedures installed to supplement and support ordinary representative democracy. On this background, it reviews some arguments for genuine representation ...... of future generations within current democracy. It is concluded that what really matters in terms of the democratic ideal is to ensure an impartial deliberation which takes the interests of all affected parties sufficiently into account....... of future generations. The analysis reveals that they tend to overlook the democratic costs of such representation (violation of political equality, risk of distortion of the deliberation and undermining of autonomy), while they seem to ignore the alternative of giving consideration to the interests...

  13. Alternative medicine - pain relief

    Science.gov (United States)

    Alternative medicine refers to treatments that are used instead of conventional (standard) ones. If you use an alternative ... with conventional medicine or therapy, it is considered complementary therapy. There are many forms of alternative medicine. Acupuncture ...

  14. Property description and fact-finding report for NPR-3 Natrona County, Wyoming. Addendum to 22 August 1996 study of alternatives for future operations of the naval petroleum and oil shale reserves NPR-3

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-05-01

    The U.S. Department of Energy has asked Gustavson Associates, Inc. to serve as an Independent Petroleum Consultant under contract DE-AC01-96FE64202. This authorizes a study and recommendations regarding future development of Naval Petroleum Reserve No. 3 (NPR-3) in Natrona County, Wyoming. The report that follows is the Phase I fact-finding and property description for that study. The United States of America owns 100 percent of the mineral rights and surface rights in 9,321-acre NPR-3. This property comprises the Teapot Dome oil field and related production, processing and other facilities. Discovered in 1914, this field has 632 wells producing 1,807 barrels of oil per day. Production revenues are about $9.5 million per year. Remaining recoverable reserves are approximately 1.3 million barrels of oil. Significant plugging and abandonment (P&A) and environmental liabilities are present.

  15. Pathways to plausibility

    DEFF Research Database (Denmark)

    Wahlberg, Ayo

    2008-01-01

    Herbal medicine has long been contrasted to modern medicine in terms of a holistic approach to healing, vitalistic theories of health and illness and an emphasis on the body’s innate self-healing capacities. At the same time, since the early 20th century, the cultivation, preparation and mass...

  16. Pathways to plausibility

    DEFF Research Database (Denmark)

    Wahlberg, Ayo

    2008-01-01

    Herbal medicine has long been contrasted to modern medicine in terms of a holistic approach to healing, vitalistic theories of health and illness and an emphasis on the body’s innate self-healing capacities. At the same time, since the early 20th century, the cultivation, preparation and mass pro...... as normalised, with herbalists, phytochemists and pharmacologists working to develop standardised production procedures as well as to identify ‘plausible’ explanations for the efficacy of these remedies....

  17. Future directions.

    Science.gov (United States)

    Raffa, Robert B; Tallarida, Ronald J

    2010-01-01

    The chapters of this book summarize much of what has been done and reported regarding cancer chemotherapy-related cognitive impairment. In this chapter, we point out some future directions for investigation.

  18. Sustainable Futures

    Science.gov (United States)

    Sustainable Futures is a voluntary program that encourages industry to use predictive models to screen new chemicals early in the development process and offers incentives to companies subject to TSCA section 5.

  19. Robot Futures

    DEFF Research Database (Denmark)

    Christoffersen, Anja; Grindsted Nielsen, Sally; Jochum, Elizabeth Ann;

    Robots are increasingly used in health care settings, e.g., as homecare assistants and personal companions. One challenge for personal robots in the home is acceptance. We describe an innovative approach to influencing the acceptance of care robots using theatrical performance. Live performance i...... perceive social robots interacting with humans in a future care scenario through a scripted performance. We discuss our methods and initial findings, and outline future work....

  20. Homeopathy--quackery or a key to the future of medicine?

    Science.gov (United States)

    Gold, Peter W; Novella, S; Roy, R; Marcus, D; Bell, I; Davidovitch, N; Saine, A

    2008-01-01

    This is an edited transcript of a debate held at the University of Connecticut Health Center, Farmington, Connecticut, USA on 25 October 2007. Homeopathy is a widely used but controversial form of complementary and alternative medicine. Six distinguished international speakers, including advocates and skeptics concerning homeopathy, debated the plausibility, theoretical principles, clinical and basic research evidence, ethical and other issues surrounding homeopathy.

  1. All About Alternatives

    Science.gov (United States)

    Barr, Robert D.; And Others

    1972-01-01

    A primer on alternative schools. Described are existing programs in different areas, philosophy of the alternative schools, funding, student behavior, community relations, accountability, State regulations, management, and the environment of the alternative school. A list of sources of additional information on alternative schools is included.…

  2. The induction ability of qualitative plausibility measures in default reasoning%量化plausibility测度在默认推理系统中的推理能力

    Institute of Scientific and Technical Information of China (English)

    霍旭辉; 寇辉

    2011-01-01

    作者讨论了量化plausibility测度在默认推理逻辑系统(P系统)中的推理能力,给出了一般量化plausibility测度与possibility测度具有相同推理能力的条件.%In this paper,the authors investigate the induction ability of qualitative plausibility measures in default reasoning,and obtain the conditions such that the general qualitative plausibility measures and the possibilty measures have the same induction in default reasoning.

  3. Alternative splicing interference by xenobiotics.

    Science.gov (United States)

    Zaharieva, Emanuela; Chipman, J Kevin; Soller, Matthias

    2012-06-14

    The protein coding sequence of most eukaryotic genes (exons) is interrupted by non-coding parts (introns), which are excised in a process termed splicing. To generate a mature messenger RNA (mRNA) hundreds of combinatorial protein-protein and RNA-protein interactions are required to splice out often very large introns with high fidelity and accuracy. Inherent to splicing is the use of alternative splice sites generating immense proteomic diversity from a limited number of genes. In humans, alternative splicing is a major mode of regulating gene expression, occurs in over 90% of genes and is particularly abundant in the brain. Only recently, it has been recognized that the complexity of the splicing process makes it susceptible to interference by various xenobiotics. These compounds include antineoplastic substances, commonly used drugs and food supplements and cause a spectrum of effects ranging from deleterious inhibition of general splicing to highly specific modifications of alternative splicing affecting only certain genes. Alterations in splicing have been implicated in numerous diseases such as cancer and neurodegeneration. Splicing regulation plays an important role in the execution of programmed cell death. The switch between anti- and pro-apoptotic isoforms by alternative splice site selection and misregulation of a number of splicing factors impacts on cell survival and disease. Here, our current knowledge is summarized on compounds interfering with general and alternative splicing and of the current methodology to study changes in these processes relevant to the field of toxicology and future risk assessments.

  4. Plausible Drug Targets in the Streptococcus mutans Quorum Sensing Pathways to Combat Dental Biofilms and Associated Risks.

    Science.gov (United States)

    Kaur, Gurmeet; Rajesh, Shrinidhi; Princy, S Adline

    2015-12-01

    Streptococcus mutans, a Gram positive facultative anaerobe, is one among the approximately seven hundred bacterial species to exist in human buccal cavity and cause dental caries. Quorum sensing (QS) is a cell-density dependent communication process that respond to the inter/intra-species signals and elicit responses to show behavioral changes in the bacteria to an aggressive forms. In accordance to this phenomenon, the S. mutans also harbors a Competing Stimulating Peptide (CSP)-mediated quorum sensing, ComCDE (Two-component regulatory system) to regulate several virulence-associated traits that includes the formation of the oral biofilm (dental plaque), genetic competence and acidogenicity. The QS-mediated response of S. mutans adherence on tooth surface (dental plaque) imparts antibiotic resistance to the bacterium and further progresses to lead a chronic state, known as periodontitis. In recent years, the oral streptococci, S. mutans are not only recognized for its cariogenic potential but also well known to worsen the infective endocarditis due to its inherent ability to colonize and form biofilm on heart valves. The review significantly appreciate the increasing complexity of the CSP-mediated quorum-sensing pathway with a special emphasis to identify the plausible drug targets within the system for the development of anti-quorum drugs to control biofilm formation and associated risks.

  5. Three-layered metallodielectric nanoshells: plausible meta-atoms for metamaterials with isotropic negative refractive index at visible wavelengths.

    Science.gov (United States)

    Wu, DaJian; Jiang, ShuMin; Cheng, Ying; Liu, XiaoJun

    2013-01-14

    A three-layered Ag-low-permittivity (LP)-high-permittivity (HP) nanoshell is proposed as a plausible meta-atom for building the three-dimensional isotropic negative refractive index metamaterials (NIMs). The overlap between the electric and magnetic responses of Ag-LP-HP nanoshell can be realized by designing the geometry of the particle, which can lead to the negative electric and magnetic polarizabilities. Then, the negative refractive index is found in the random arrangement of Ag-LP-HP nanoshells. Especially, the modulation of the middle LP layer can move the negative refractive index range into the visible region. Because the responses arise from the each meta-atom, the metamaterial is intrinsically isotropic and polarization independent. It is further found with the increase of the LP layer thickness that the negative refractive index range of the random arrangement shows a large blue-shift and becomes narrow. With the decrease of the filling fraction, the negative refractive index range shows a blue-shift and becomes narrow while the maximum of the negative refractive index decreases.

  6. Non-canonical 3'-5' extension of RNA with prebiotically plausible ribonucleoside 2',3'-cyclic phosphates.

    Science.gov (United States)

    Mutschler, Hannes; Holliger, Philipp

    2014-04-09

    Ribonucleoside 2',3'-cyclic phosphates (N>p's) are generated by multiple prebiotically plausible processes and are credible building blocks for the assembly of early RNA oligomers. While N>p's can be polymerized into short RNAs by non-enzymatic processes with variable efficiency and regioselectivity, no enzymatic route for RNA synthesis had been described. Here we report such a non-canonical 3'-5' nucleotidyl transferase activity. We engineered a variant of the hairpin ribozyme to catalyze addition of all four N>p's (2',3'-cyclic A-, G-, U-, and CMP) to the 5'-hydroxyl termini of RNA strands with 5' nucleotide addition enhanced in all cases by eutectic ice phase formation at -7 °C. We also observed 5' addition of 2',3'-cyclic phosphate-activated β-nicotinamide adenine dinucleotide (NAD>p) and ACA>p RNA trinucleotide, and multiple additions of GUCCA>p RNA pentamers. Our results establish a new mode of RNA 3'-5' extension with implications for RNA oligomer synthesis from prebiotic nucleotide pools.

  7. Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of morphostats

    Directory of Open Access Journals (Sweden)

    Cappuccio Antonio

    2009-03-01

    Full Text Available Abstract Background There is experimental evidence from animal models favoring the notion that the disruption of interactions between stroma and epithelium plays an important role in the initiation of carcinogenesis. These disrupted interactions are hypothesized to be mediated by molecules, termed morphostats, which diffuse through the tissue to determine cell phenotype and maintain tissue architecture. Methods We developed a computer simulation based on simple properties of cell renewal and morphostats. Results Under the computer simulation, the disruption of the morphostat gradient in the stroma generated epithelial precursors of cancer without any mutation in the epithelium. Conclusion The model is consistent with the possibility that the accumulation of genetic and epigenetic changes found in tumors could arise after the formation of a founder population of aberrant cells, defined as cells that are created by low or insufficient morphostat levels and that no longer respond to morphostat concentrations. Because the model is biologically plausible, we hope that these results will stimulate further experiments.

  8. Bilinguals' Plausibility Judgments for Phrases with a Literal vs. Non-literal Meaning: The Influence of Language Brokering Experience

    Directory of Open Access Journals (Sweden)

    Belem G. López

    2017-09-01

    Full Text Available Previous work has shown that prior experience in language brokering (informal translation may facilitate the processing of meaning within and across language boundaries. The present investigation examined the influence of brokering on bilinguals' processing of two word collocations with either a literal or a figurative meaning in each language. Proficient Spanish-English bilinguals classified as brokers or non-brokers were asked to judge if adjective+noun phrases presented in each language made sense or not. Phrases with a literal meaning (e.g., stinging insect were interspersed with phrases with a figurative meaning (e.g., stinging insult and non-sensical phrases (e.g., stinging picnic. It was hypothesized that plausibility judgments would be facilitated for literal relative to figurative meanings in each language but that experience in language brokering would be associated with a more equivalent pattern of responding across languages. These predictions were confirmed. The findings add to the body of empirical work on individual differences in language processing in bilinguals associated with prior language brokering experience.

  9. Synchronous volcanic eruptions and abrupt climate change ∼17.7 ka plausibly linked by stratospheric ozone depletion.

    Science.gov (United States)

    McConnell, Joseph R; Burke, Andrea; Dunbar, Nelia W; Köhler, Peter; Thomas, Jennie L; Arienzo, Monica M; Chellman, Nathan J; Maselli, Olivia J; Sigl, Michael; Adkins, Jess F; Baggenstos, Daniel; Burkhart, John F; Brook, Edward J; Buizert, Christo; Cole-Dai, Jihong; Fudge, T J; Knorr, Gregor; Graf, Hans-F; Grieman, Mackenzie M; Iverson, Nels; McGwire, Kenneth C; Mulvaney, Robert; Paris, Guillaume; Rhodes, Rachael H; Saltzman, Eric S; Severinghaus, Jeffrey P; Steffensen, Jørgen Peder; Taylor, Kendrick C; Winckler, Gisela

    2017-09-05

    Glacial-state greenhouse gas concentrations and Southern Hemisphere climate conditions persisted until ∼17.7 ka, when a nearly synchronous acceleration in deglaciation was recorded in paleoclimate proxies in large parts of the Southern Hemisphere, with many changes ascribed to a sudden poleward shift in the Southern Hemisphere westerlies and subsequent climate impacts. We used high-resolution chemical measurements in the West Antarctic Ice Sheet Divide, Byrd, and other ice cores to document a unique, ∼192-y series of halogen-rich volcanic eruptions exactly at the start of accelerated deglaciation, with tephra identifying the nearby Mount Takahe volcano as the source. Extensive fallout from these massive eruptions has been found >2,800 km from Mount Takahe. Sulfur isotope anomalies and marked decreases in ice core bromine consistent with increased surface UV radiation indicate that the eruptions led to stratospheric ozone depletion. Rather than a highly improbable coincidence, circulation and climate changes extending from the Antarctic Peninsula to the subtropics-similar to those associated with modern stratospheric ozone depletion over Antarctica-plausibly link the Mount Takahe eruptions to the onset of accelerated Southern Hemisphere deglaciation ∼17.7 ka.

  10. X-ray investigation of the diffuse emission around plausible gamma-ray emitting pulsar wind nebulae in Kookaburra region

    CERN Document Server

    Kishishita, Tetsuichi; Uchiyama, Yasunobu; Tanaka, Yasuyuki; Takahashi, Tadayuki

    2012-01-01

    We report on the results from {\\it Suzaku} X-ray observations of the radio complex region called Kookaburra, which includes two adjacent TeV $\\gamma$-ray sources HESS J1418-609 and HESS J1420-607. The {\\it Suzaku} observation revealed X-ray diffuse emission around a middle-aged pulsar PSR J1420-6048 and a plausible PWN Rabbit with elongated sizes of $\\sigma_{\\rm X}=1^{\\prime}.66$ and $\\sigma_{\\rm X}=1^{\\prime}.49$, respectively. The peaks of the diffuse X-ray emission are located within the $\\gamma$-ray excess maps obtained by H.E.S.S. and the offsets from the $\\gamma$-ray peaks are $2^{\\prime}.8$ for PSR J1420-6048 and $4^{\\prime}.5$ for Rabbit. The X-ray spectra of the two sources were well reproduced by absorbed power-law models with $\\Gamma=1.7-2.3$. The spectral shapes tend to become softer according to the distance from the X-ray peaks. Assuming the one zone electron emission model as the first order approximation, the ambient magnetic field strengths of HESS J1420-607 and HESS J1418-609 can be estimate...

  11. Bethe-Heitler cascades as a plausible origin of hard spectra in distant TeV blazars

    CERN Document Server

    Zheng, Y G; Kang, S J

    2016-01-01

    Context. Very high-energy (VHE) $\\gamma$-ray measurements of distant TeV blazars can be nicely explained by TeV spectra induced by ultra high-energy cosmic rays. Aims. We develop a model for a plausible origin of hard spectra in distant TeV blazars. Methods. In the model, the TeV emission in distant TeV blazars is dominated by two mixed components. The first is the internal component with the photon energy around 1 TeV produced by inverse Compton scattering of the relativistic electrons on the synchrotron photons (SSC) with a correction for extragalactic background light absorbtion and the other is the external component with the photon energy more than 1 TeV produced by the cascade emission from high-energy protons propagating through intergalactic space. Results. Assuming suitable model parameters, we apply the model to observed spectra of distant TeV blazars of 1ES 0229+200. Our results show that 1) the observed spectrum properties of 1ES 0229+200, especially the TeV $\\gamma$-ray tail of the observed spect...

  12. Simultaneous observations of a pair of kilohertz QPOs and a plausible 1860 Hz QPO from an accreting neutron star system

    CERN Document Server

    Bhattacharyya, Sudip

    2009-01-01

    We report an indication (3.22 sigma) of ~ 1860 Hz quasi-periodic oscillations from a neutron star low-mass X-ray binary 4U 1636-536. If confirmed, this will be by far the highest frequency feature observed from an accreting neutron star system, and hence could be very useful to understand such systems. This plausible timing feature was observed simultaneously with lower (~ 585 Hz) and upper (~ 904 Hz) kilohertz quasi-periodic oscillations. The two kilohertz quasi-periodic oscillation frequencies had the ratio of ~ 1.5, and the frequency of the alleged ~ 1860 Hz feature was close to the triple and the double of these frequencies. This can be useful to constrain the models of all the three features. In particular, the ~ 1860 Hz feature could be (1) from a new and heretofore unknown class of quasi-periodic oscillations, or (2) the first observed overtone of lower or upper kilohertz quasi-periodic oscillations. Finally we note that, although the relatively low significance of the ~ 1860 Hz feature argues for caut...

  13. Synchronous volcanic eruptions and abrupt climate change ˜17.7 ka plausibly linked by stratospheric ozone depletion

    Science.gov (United States)

    McConnell, Joseph R.; Burke, Andrea; Dunbar, Nelia W.; Köhler, Peter; Thomas, Jennie L.; Arienzo, Monica M.; Chellman, Nathan J.; Maselli, Olivia J.; Sigl, Michael; Adkins, Jess F.; Baggenstos, Daniel; Burkhart, John F.; Brook, Edward J.; Buizert, Christo; Cole-Dai, Jihong; Fudge, T. J.; Knorr, Gregor; Graf, Hans-F.; Grieman, Mackenzie M.; Iverson, Nels; McGwire, Kenneth C.; Mulvaney, Robert; Paris, Guillaume; Rhodes, Rachael H.; Saltzman, Eric S.; Severinghaus, Jeffrey P.; Steffensen, Jørgen Peder; Taylor, Kendrick C.; Winckler, Gisela

    2017-09-01

    Glacial-state greenhouse gas concentrations and Southern Hemisphere climate conditions persisted until ˜17.7 ka, when a nearly synchronous acceleration in deglaciation was recorded in paleoclimate proxies in large parts of the Southern Hemisphere, with many changes ascribed to a sudden poleward shift in the Southern Hemisphere westerlies and subsequent climate impacts. We used high-resolution chemical measurements in the West Antarctic Ice Sheet Divide, Byrd, and other ice cores to document a unique, ˜192-y series of halogen-rich volcanic eruptions exactly at the start of accelerated deglaciation, with tephra identifying the nearby Mount Takahe volcano as the source. Extensive fallout from these massive eruptions has been found >2,800 km from Mount Takahe. Sulfur isotope anomalies and marked decreases in ice core bromine consistent with increased surface UV radiation indicate that the eruptions led to stratospheric ozone depletion. Rather than a highly improbable coincidence, circulation and climate changes extending from the Antarctic Peninsula to the subtropics—similar to those associated with modern stratospheric ozone depletion over Antarctica—plausibly link the Mount Takahe eruptions to the onset of accelerated Southern Hemisphere deglaciation ˜17.7 ka.

  14. Removal of hazardous organics from water using metal-organic frameworks (MOFs): plausible mechanisms for selective adsorptions.

    Science.gov (United States)

    Hasan, Zubair; Jhung, Sung Hwa

    2015-01-01

    Provision of clean water is one of the most important issues worldwide because of continuing economic development and the steady increase in the global population. However, clean water resources are decreasing everyday, because of contamination with various pollutants including organic chemicals. Pharmaceutical and personal care products, herbicides/pesticides, dyes, phenolics, and aromatics (from sources such as spilled oil) are typical organics that should be removed from water. Because of their huge porosities, designable pore structures, and facile modification, metal-organic frameworks (MOFs) are used in various adsorption, separation, storage, and delivery applications. In this review, the adsorptive purifications of contaminated water with MOFs are discussed, in order to understand possible applications of MOFs in clean water provision. More importantly, plausible adsorption or interaction mechanisms and selective adsorptions are summarized. The mechanisms of interactions such as electrostatic interaction, acid-base interaction, hydrogen bonding, π-π stacking/interaction, and hydrophobic interaction are discussed for the selective adsorption of organics over MOFs. The adsorption mechanisms will be very helpful not only for understanding adsorptions but also for applications of adsorptions in selective removal, storage, delivery and so on.

  15. Future High Capacity Backbone Networks

    DEFF Research Database (Denmark)

    Wang, Jiayuan

    This thesis - Future High Capacity Backbone Networks - deals with the energy efficiency problems associated with the development of future optical networks. In the first half of the thesis, novel approaches for using multiple/single alternative energy sources for improving energy efficiency...... the context of the integrated control plane structure. Results show improvements of energy efficiency over three types of traffic, while still keeping acceptable QoS levels for high priority traffic....

  16. Energy Futures

    DEFF Research Database (Denmark)

    Davies, Sarah Rachael; Selin, Cynthia

    2012-01-01

    foresight and public and stakeholder engagement are used to reflect on?and direct?the impacts of new technology. In this essay we draw on our experience of anticipatory governance, in the shape of the ?NanoFutures? project on energy futures, to present a reflexive analysis of engagement and deliberation. We...... draw out five tensions of the practice of deliberation on energy technologies. Through tracing the lineages of these dilemmas, we discuss some of the implications of these tensions for the practice of civic engagement and deliberation in a set of questions for this community of practitioner-scholars....

  17. Energy Futures

    DEFF Research Database (Denmark)

    Davies, Sarah Rachael; Selin, Cynthia

    2012-01-01

    foresight and public and stakeholder engagement are used to reflect on?and direct?the impacts of new technology. In this essay we draw on our experience of anticipatory governance, in the shape of the ?NanoFutures? project on energy futures, to present a reflexive analysis of engagement and deliberation. We...... draw out five tensions of the practice of deliberation on energy technologies. Through tracing the lineages of these dilemmas, we discuss some of the implications of these tensions for the practice of civic engagement and deliberation in a set of questions for this community of practitioner-scholars....

  18. Future Contingents

    DEFF Research Database (Denmark)

    Øhrstrøm, Peter; Hasle., Per F. V.

    2011-01-01

    will be a sea-battle tomorrow” could serve as standard examples. What could be called the problem of future contingents concerns how to ascribe truth-values to such statements. If there are several possible decisions out of which one is going to be made freely tomorrow, can there be a truth now about which one...... about the future. Finally, it should be mentioned that temporal logic has found a remarkable application in computer science and applied mathematics. In the late 1970s the first computer scientists realised the relevance of temporal logic for the purposes of computer science (see Hasle and Øhrstrøm 2004)....

  19. The future water environment--using scenarios to explore the significant water management challenges in England and Wales to 2050.

    Science.gov (United States)

    Henriques, C; Garnett, K; Weatherhead, E K; Lickorish, F A; Forrow, D; Delgado, J

    2015-04-15

    Society gets numerous benefits from the water environment. It is crucial to ensure that water management practices deliver these benefits over the long-term in a sustainable and cost-effective way. Currently, hydromorphological alterations and nutrient enrichment pose the greatest challenges in European water bodies. The rapidly changing climatic and socio-economic boundary conditions pose further challenges to water management decisions and the achievement of policy goals. Scenarios are a strategic tool useful in conducting systematic investigations of future uncertainties pertaining to water management. In this study, the use of scenarios revealed water management challenges for England and Wales to 2050. A set of existing scenarios relevant to river basin management were elaborated through stakeholder workshops and interviews, relying on expert knowledge to identify drivers of change, their interdependencies, and influence on system dynamics. In a set of four plausible alternative futures, the causal chain from driving forces through pressures to states, impacts and responses (DPSIR framework) was explored. The findings suggest that scenarios driven by short-term economic growth and competitiveness undermine current environmental legislative requirements and exacerbate the negative impacts of climate change, producing a general deterioration of water quality and physical habitats, as well as reduced water availability with adverse implications for the environment, society and economy. Conversely, there are substantial environmental improvements under the scenarios characterised by long-term sustainability, though achieving currently desired environmental outcomes still poses challenges. The impacts vary across contrasting generic catchment types that exhibit distinct future water management challenges. The findings suggest the need to address hydromorphological alterations, nutrient enrichment and nitrates in drinking water, which are all likely to be

  20. Futur "simple" et futur "proche" ("Simple" Future and "Immediate" Future).

    Science.gov (United States)

    Franckel, Jean-Jacques

    1984-01-01

    An analysis of the use of simple and immediate future tenses in French shows that the expression of time is controlled more by context and modals than by specifically temporal cues. The role of negation in this situation is discussed. (MSE)

  1. Creative Futures

    Science.gov (United States)

    Feasey, Rosemary

    2003-01-01

    In 1999 the National Committee for Creativity and Culture in Education (NACCCE) produced a report called "All our futures." In many respects it was and still is a seminal report; it raises issues about creativity in education and offers serious messages for Government, schools and the inspection process. The author's research into teacher…

  2. 17 CFR 242.301 - Requirements for alternative trading systems.

    Science.gov (United States)

    2010-04-01

    ... trading systems. 242.301 Section 242.301 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... FUTURES Regulation Ats-Alternative Trading Systems § 242.301 Requirements for alternative trading systems. (a) Scope of section. An alternative trading system shall comply with the requirements in...

  3. Future of Electrotechnics: Ferrofluids

    Directory of Open Access Journals (Sweden)

    Daniel Mayer

    2008-01-01

    Full Text Available Magnetic liquids enabled development of new devices and technologies that are a useful alternative to theexisting ones. Many of these applications are still in progress and do not represent any break-through discoveries yet.Nevertheless one may expect that owing to their remarkable qualities magnetic fluids will become in the future a part oforiginal projects. The research of magnetic liquids has a strongly multidisciplinary character. It is thus desirable fortechnicians of different specializations or other specialists (such as physicians, biologists, pharmacists etc. to be acquaintedwith the qualities and existing applications of these perspective materials.

  4. On Matrix Sampling and Imputation of Context Questionnaires with Implications for the Generation of Plausible Values in Large-Scale Assessments

    Science.gov (United States)

    Kaplan, David; Su, Dan

    2016-01-01

    This article presents findings on the consequences of matrix sampling of context questionnaires for the generation of plausible values in large-scale assessments. Three studies are conducted. Study 1 uses data from PISA 2012 to examine several different forms of missing data imputation within the chained equations framework: predictive mean…

  5. World Literacy Prospects at the Turn of the Century: Is the Objective of Literacy for All by the Year 2000 Statistically Plausible?

    Science.gov (United States)

    Carceles, Gabriel

    1990-01-01

    Describes status and challenge of worldwide illiteracy. Discusses statistical plausibility of universal literacy by 2000. Predicts literacy universalization will take from 14 to 21 years, depending on region, if 1980s trends continue. Implies literacy work requires action strategies commensurate with problem, including national programs and mass…

  6. Alternative Compression Garments

    Science.gov (United States)

    Stenger, M. B.; Lee, S. M. C.; Ribeiro, L. C.; Brown, A. K.; Westby, C. M.; Platts, S. H.

    2011-01-01

    Orthostatic intolerance after spaceflight is still an issue for astronauts as no in-flight countermeasure has been 100% effective. Future anti-gravity suits (AGS) may be similar to the Shuttle era inflatable AGS or may be a mechanical compression device like the Russian Kentavr. We have evaluated the above garments as well as elastic, gradient compression garments of varying magnitude and determined that breast-high elastic compression garments may be a suitable replacement to the current AGS. This new garment should be more comfortable than the AGS, easy to don and doff, and as effective a countermeasure to orthostatic intolerance. Furthermore, these new compression garments could be worn for several days after space flight as necessary if symptoms persisted. We conducted two studies to evaluate elastic, gradient compression garments. The purpose of these studies was to evaluate the comfort and efficacy of an alternative compression garment (ACG) immediately after actual space flight and 6 degree head-down tilt bed rest as a model of space flight, and to determine if they would impact recovery if worn for up to three days after bed rest.

  7. World Energy Future

    Energy Technology Data Exchange (ETDEWEB)

    Forbes, A.; Van der Linde, C.; Nicola, S.

    2009-03-15

    In the section World Energy Future of this magazine two articles, two interviews and one column are presented. The article 'A green example to the world' refers briefly to the second World Future Energy Summit in Abu Dhabi, which was held from 18-21 January, 2009. The second article, 'Green Utopia in the desert' attention is paid to the Abu Dhabi government-driven Masdar Initiative. The two interviews concern an interview with BP Alternative Energy ceo Vivienne Cox, and an interview with the founder and CEO of New Energy Finance Michael Liebreich. The column ('An efficient response') focuses on the impact of the economic crisis on energy policy.

  8. Combination of monoclonal antibodies and DPP-IV inhibitors in the treatment of type 1 diabetes: a plausible treatment modality?

    Science.gov (United States)

    Dubala, Anil; Gupta, Ankur; Samanta, Malay K

    2014-07-01

    Regulatory T cells (Tregs) are crucial for the maintenance of immunological tolerance. Type 1 diabetes (T1D) occurs when the immune-regulatory mechanism fails. In fact, T1D is reversed by islet transplantation but is associated with hostile effects of persistent immune suppression. T1D is believed to be dependent on the activation of type-1 helper T (Th1) cells. Immune tolerance is liable for the activation of the Th1 cells. The important role of Th1 cells in pathology of T1D entails the depletion of CD4(+) T cells, which initiated the use of monoclonal antibodies (mAbs) against CD4(+) T cells to interfere with induction of T1D. Prevention of autoimmunity is not only a step forward for the treatment of T1D, but could also restore the β-cell mass. Glucagon-like peptide (GLP)-1 stimulates β-cell proliferation and also has anti-apoptotic effects on them. However, the potential use of GLP-1 as a possible method to restore pancreatic β-cells is limited due to rapid degradation by dipeptidyl peptidase (DPP)-IV. We hypothesize that treatment with combination of CD4 mAbs and DPP-IV inhibitors could prevent/reverse T1D. CD4 mAbs have the ability to induce immune tolerance, thereby arresting further progression of T1D; DPP-IV inhibitors have the capability to regenerate the β-cell mass. Consequently, the combination of CD4 mAbs and DPP-IV inhibitor could avoid or at least minimize the constraints of intensive subcutaneous insulin therapy. We presume that if this hypothesis proves correct, it may become one of the plausible therapeutic options for T1D.

  9. In Silico Structure Prediction of Human Fatty Acid Synthase-Dehydratase: A Plausible Model for Understanding Active Site Interactions.

    Science.gov (United States)

    John, Arun; Umashankar, Vetrivel; Samdani, A; Sangeetha, Manoharan; Krishnakumar, Subramanian; Deepa, Perinkulam Ravi

    2016-01-01

    Fatty acid synthase (FASN, UniProt ID: P49327) is a multienzyme dimer complex that plays a critical role in lipogenesis. Consequently, this lipogenic enzyme has gained tremendous biomedical importance. The role of FASN and its inhibition is being extensively researched in several clinical conditions, such as cancers, obesity, and diabetes. X-ray crystallographic structures of some of its domains, such as β-ketoacyl synthase, acetyl transacylase, malonyl transacylase, enoyl reductase, β-ketoacyl reductase, and thioesterase, (TE) are already reported. Here, we have attempted an in silico elucidation of the uncrystallized dehydratase (DH) catalytic domain of human FASN. This theoretical model for DH domain was predicted using comparative modeling methods. Different stand-alone tools and servers were used to validate and check the reliability of the predicted models, which suggested it to be a highly plausible model. The stereochemical analysis showed 92.0% residues in favorable region of Ramachandran plot. The initial physiological substrate β-hydroxybutyryl group was docked into active site of DH domain using Glide. The molecular dynamics simulations carried out for 20 ns in apo and holo states indicated the stability and accuracy of the predicted structure in solvated condition. The predicted model provided useful biochemical insights into the substrate-active site binding mechanisms. This model was then used for identifying potential FASN inhibitors using high-throughput virtual screening of the National Cancer Institute database of chemical ligands. The inhibitory efficacy of the top hit ligands was validated by performing molecular dynamics simulation for 20 ns, where in the ligand NSC71039 exhibited good enzyme inhibition characteristics and exhibited dose-dependent anticancer cytotoxicity in retinoblastoma cancer cells in vitro.

  10. Prospecting the future with AI

    Directory of Open Access Journals (Sweden)

    Julian Gonzalez

    2009-12-01

    Full Text Available If we were able to foresee the future, we could be prepared to reduce the impact of bad situations as well as getting the most of profiting periods. Our world is a dynamic system that evolves as time goes by. The number of variables that can influence in future situations outnumbers our capacity of prediction at a first glance. This article will show an alternative way to foresee potential future scenarios based on human experts’ opinion, what can be considered as aknowledge modeling tool.

  11. Framing the future of fracking

    NARCIS (Netherlands)

    Metze, Tamara

    2017-01-01

    Hydraulic fracturing is a technology developed to improve and increase the production of natural gas. In many countries, including the Netherlands, it has caused environmental controversies. In these controversies, 'futurity framing' may open up debates for alternative paradigms such as

  12. Robot Futures

    DEFF Research Database (Denmark)

    Christoffersen, Anja; Grindsted Nielsen, Sally; Jochum, Elizabeth Ann

    Robots are increasingly used in health care settings, e.g., as homecare assistants and personal companions. One challenge for personal robots in the home is acceptance. We describe an innovative approach to influencing the acceptance of care robots using theatrical performance. Live performance...... is a useful testbed for developing and evaluating what makes robots expressive; it is also a useful platform for designing robot behaviors and dialogue that result in believable characters. Therefore theatre is a valuable testbed for studying human-robot interaction (HRI). We investigate how audiences...... perceive social robots interacting with humans in a future care scenario through a scripted performance. We discuss our methods and initial findings, and outline future work....

  13. My Future

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    正My fellow classmates, Everyone of us is thinking about the future. What is mine? I have decided become a middle school teacher. Does it sound surprising? I had his dream when I was only a child. I love children. I don't think to deal with them all years round is just wasting time. On the contrary, to me it would mean happiness. As we all can see, teachers are badly needed in our country,

  14. Scheduling Future Water Supply Investments Under Uncertainty

    Science.gov (United States)

    Huskova, I.; Matrosov, E. S.; Harou, J. J.; Kasprzyk, J. R.; Reed, P. M.

    2014-12-01

    Uncertain hydrological impacts of climate change, population growth and institutional changes pose a major challenge to planning of water supply systems. Planners seek optimal portfolios of supply and demand management schemes but also when to activate assets whilst considering many system goals and plausible futures. Incorporation of scheduling into the planning under uncertainty problem strongly increases its complexity. We investigate some approaches to scheduling with many-objective heuristic search. We apply a multi-scenario many-objective scheduling approach to the Thames River basin water supply system planning problem in the UK. Decisions include which new supply and demand schemes to implement, at what capacity and when. The impact of different system uncertainties on scheme implementation schedules are explored, i.e. how the choice of future scenarios affects the search process and its outcomes. The activation of schemes is influenced by the occurrence of extreme hydrological events in the ensemble of plausible scenarios and other factors. The approach and results are compared with a previous study where only the portfolio problem is addressed (without scheduling).

  15. Vowel alternations in English

    OpenAIRE

    Kazumi, Yukiko

    1992-01-01

    The purpose of this study is to investigate the nature of vowel alternations observed in English. What we call vowel alternations here consists of shortening and lengthening triggered by Level I affixation: ...

  16. Nanometric alternating magnetic field generator.

    Science.gov (United States)

    Espejo, A P; Tejo, F; Vidal-Silva, N; Escrig, J

    2017-07-05

    In this work we introduce an alternating magnetic field generator in a cylindrical nanostructure. This field appears due to the rotation of a magnetic domain wall located at some position, generating a magnetic region that varies its direction of magnetization alternately, thus inducing an alternating magnetic flux in its vicinity. This phenomenon occurs due to the competition between a spin-polarized current and a magnetic field, which allows to control both the angular velocity and the pinning position of the domain wall. As proof of concept, we study the particular case of a diameter-modulated nanowire with a spin-polarized current along its axis and the demagnetizing field produced by its modulation. This inhomogeneous field allows one to control the angular velocity of the domain wall as a function of its position along the nanowire allowing frequencies in the GHz range to be achieved. This generator could be used in telecommunications for devices in the range of radiofrequencies or, following Faraday's induction law, could also induce an electromotive force and be used as a movable alternate voltage source in future nanodevices.

  17. Alternative energies. Updates on progress

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, German (ed.) [CIRCE - Centre of Research for Energy Resources and Consumption, Zaragoza (Spain)

    2013-07-01

    Presents fundamental and applied research of alternative energies. Address key pillars in the alternative energy field, such as: biomass energy, hydrogen energy, solar energy, wind energy, hydroelectric power, geothermal energy and their environmental implications, with the most updated progress. Includes the life cycle assessment and thermoeconomic analysis as tools for evaluating and optimising environmental and cost subjects. This book presents nine chapters based on fundamental and applied research of alternative energies. At the present time, the challenge is that technology has to come up with solutions that can provide environmentally friendly energy supply options that are able to cover the current world energy demand. Experts around the world are working on these issues for providing new solutions that will break the existing technological barriers. This book aims to address key pillars in the alternative energy field, such as: biomass energy, hydrogen energy, solar energy, wind energy, hydroelectric power, geothermal energy and their environmental implications, with the most updated progress for each pillar. It also includes the life cycle assessment (LCA) and thermoeconomic analysis (TA) as tools for evaluating and optimising environmental and cost subjects. Chapters are organized into fundamental research, applied research and future trends; and written for engineers, academic researches and scientists.

  18. Climate modelling: IPCC gazes into the future

    Science.gov (United States)

    Raper, Sarah

    2012-04-01

    In 2013, the Intergovernmental Panel on Climate Change will report on the next set of future greenhouse-gas emission scenarios, offering a rational alternative pathway for avoiding dangerous climate change.

  19. Emissions from international shipping: 2. Impact of future technologies on scenarios until 2050

    Science.gov (United States)

    Eyring, V.; KöHler, H. W.; Lauer, A.; Lemper, B.

    2005-09-01

    In this study the today's fleet-average emission factors of the most important ship exhausts are used to calculate emission scenarios for the future. To develop plausible future technology scenarios, first upcoming regulations and compliance with future regulations through technological improvements are discussed. We present geographically resolved emission inventory scenarios until 2050, based on a mid-term prognosis for 2020 and a long-term prognosis for 2050. The scenarios are based on some very strict assumptions on future ship traffic demands and technological improvements. The four future ship traffic demand scenarios are mainly determined by the economic growth, which follows the IPCC SRES storylines. The resulting fuel consumption is projected through extrapolations of historical trends in economic growth, total seaborne trade and number of ships, as well as the average installed power per ship. For the future technology scenarios we assume a diesel-only fleet in 2020 resulting in fuel consumption between 382 and 409 million metric tons (Mt). For 2050 one technology scenario assumes that 25% of the fuel consumed by a diesel-only fleet can be saved by applying future alternative propulsion plants, resulting in a fuel consumption that varies between 402 and 543 Mt. The other scenario is a business-as-usual scenario for a diesel-only fleet even in 2050 and gives an estimate between 536 and 725 Mt. Dependent on how rapid technology improvements for diesel engines are introduced, possible technology reduction factors are applied to the today's fleet-average emission factors of all important species to estimate future ship emissions. Combining the four traffic demand scenarios with the four technology scenarios, our results suggest emissions between 8.8 and 25.0 Tg (NO2) in 2020, and between 3.1 to 38.8 Tg (NO2) in 2050. The development of forecast scenarios for CO2, NOx, SOx, CO, hydrocarbons, and particulate matter is driven by the requirements for global model

  20. Alternative dimensional models of personality disorder

    DEFF Research Database (Denmark)

    Widiger, Thomas A; Simonsen, Erik

    2005-01-01

    The recognition of the many limitations of the categorical model of personality disorder classification has led to the development of quite a number of alternative proposals for a dimensional classification. The purpose of this article is to suggest that future research work toward the integration...... of these alternative proposals within a common hierarchical structure. An illustration of a potential integration is provided using the constructs assessed within existing dimensional models. Suggestions for future research that will help lead toward a common, integrative dimensional model of personality disorder...

  1. Greece is the future of Europe

    DEFF Research Database (Denmark)

    Douzinas, Costas; Risager, Bjarke Skærlund

    2014-01-01

    Austerity and popular resistance are essential to a political diagnosis for contemporary Europe. Political developments in Greece will show whether the future of Europe is one of neoliberal restructuring or one of a democratic socialist alternative. An interview with Costas Douzinas.......Austerity and popular resistance are essential to a political diagnosis for contemporary Europe. Political developments in Greece will show whether the future of Europe is one of neoliberal restructuring or one of a democratic socialist alternative. An interview with Costas Douzinas....

  2. Economics and regulation of petroleum futures markets

    Energy Technology Data Exchange (ETDEWEB)

    1980-08-01

    Because the futures market in petroleum products is a relatively recent phenomenon, the implications of public policies formulated for that market have not yet been fully explored. To provide the Office of Competition of the Department of Energy (DOE) with sufficient information to assess policy alternatives, Resource Planning Associates, Inc. (RPA) was asked to analyze the development of the futures market in No. 2 oil, assess the potential for futures markets in other petroleum products, and identify policy alternatives available to DOE. To perform this analysis, the criteria for a viable futures market was established first. Then, the experience to date with the 18-month-old futures market in No. 2 oil was examined, and the potential for viable futures markets in No. 6 oil, gasoline, jet fuel, and crude oil was assessed. Finally, how existing DOE regulations and prospective actions might affect petroleum futures market development was investigated.

  3. Alternative routes of insulin delivery

    Institute of Scientific and Technical Information of China (English)

    Ranjith K. Krishnankutty; Aju Mathew; Saikiran K. Sedimbi; Shrikumar Suryanarayan; Carani B. Sanjeevi

    2009-01-01

    Parenteral route of insulin administration has been the mode of treatment for all Type 1 diabetics and Type 2 diabetics with complications. Patient compliance has really been a major concern for this route of administration. Several alternative routes of administration are under consideration for effective glycemic control, including oral, inhaled, buccal, nasal, and patch routes. One of the approaches involving inhaled insulin has now reached the market. Several other candidates may reach the market in the near future, the promising one being oral insulin.

  4. Alternative routes of insulin delivery.

    Science.gov (United States)

    Krishnankutty, Ranjith K; Mathew, Aju; Sedimbi, Saikiran K; Suryanarayan, Shrikumar; Sanjeevi, Carani B

    2009-10-01

    Parenteral route of insulin administration has been the mode of treatment for all Type 1 diabetics and Type 2 diabetics with complications. Patient compliance has really been a major concern for this route of administration. Several alternative routes of administration are under consideration for effective glycemic control, including oral, inhaled, buccal, nasal, and patch routes. One of the approaches involving inhaled insulin has now reached the market. Several other candidates may reach the market in the near future, the promising one being oral insulin.

  5. The Security Impact of Oil Nationalization: Alternate Futures Scenarios

    Directory of Open Access Journals (Sweden)

    Peter Johnston

    2010-01-01

    Full Text Available This article highlights the security impact of oil nationalization, develops and analyzes four energy security scenarios, and suggests options to reduce the potential negative impact of oil nationalization. In addition to the use of oil as a weapon, nationalization of oil can also lead to competition for scarce resources among states, facilitate the funding of terrorists or insurgents, contribute to destabilizing regional arms races, influence intra-state conflict, and sustain antagonistic political agendas.

  6. Alternatives for Future U.S. Space-Launch Capabilities

    Science.gov (United States)

    2006-10-01

    as the crew carrier and the similarly derived top-mounted super-heavy launcher as the cargo carrier—that is, the shuttle-derived super-heavy alterna ...tive considered by CBO. Through 2017, CBO’s estimate of the budgetary resources needed to execute that alterna - tive on the more ambitious schedule...U.S. launch capacity exclude the Sea Launch system operated by Boeing in partnership with RSC- Energia (based in Moscow), Kvaerner ASA (based in Oslo

  7. Artificial lung basics: Fundamental challenges, alternative designs and future innovations

    OpenAIRE

    Nolan, Heather; Wang, Dongfang; Zwischenberger, Joseph B.

    2011-01-01

    There exists a growing demand for new technology that can take over the function of the human lung, from assisting an injured or recently transplanted lung to completely replacing the native organ. Many obstacles must be overcome to achieve the lofty goals and expectations of such a device. An artificial lung must be able to sustain the gas exchange requirements of a normal functioning lung. Pursuant to this purpose, the device must maintain appropriate blood pressure, decrease injury to bloo...

  8. Artificial lung basics: fundamental challenges, alternative designs and future innovations.

    Science.gov (United States)

    Nolan, Heather; Wang, Dongfang; Zwischenberger, Joseph B

    2011-01-01

    There exists a growing demand for new technology that can take over the function of the human lung, from assisting an injured or recently transplanted lung to completely replacing the native organ. Many obstacles must be overcome to achieve the lofty goals and expectations of such a device. An artificial lung must be able to sustain the gas exchange requirements of a normal functioning lung. Pursuant to this purpose, the device must maintain appropriate blood pressure, decrease injury to blood cells and minimize clotting and immunologic response. Attachment methods vary, and ideally researchers want to find a way that minimizes bodily trauma, maximizes gas exchange and utilizes the inherent properties of the native lung. The currently proposed methods include the parallel, in-series and venous double-lumen cannula configurations. For the time being, current research focuses on the extracorporeal (i.e., outside the body) placement, but ultimate long-term goals look toward total implantation.

  9. Victualling for Future Royal Australia Navy Platforms - Alternative Technologies

    Science.gov (United States)

    2014-11-01

    Electric Field QL Quick Look RAN Royal Australian Navy RPDE Rapid Prototyping, Development and Evaluation program SFE Supercritical Fluid ...however, to be suited to liquid or ‘pumpable’ foods such as milk , juices, sauces and soups. Many are used in the treatment of waste water in the food...the liquid, killing the cells and rendering them harmless. • Supercritical Fluids [8] – carbon dioxide is often used as a supercritical fluid . The

  10. Constructing Chains of Enablers for Alternative Economic Futures

    DEFF Research Database (Denmark)

    Hull Kristensen, Peer

    2016-01-01

    Though capitalism may be structured in divergent ways that produce highly different outcomes, and though the capitalist process needs new demands and technologies to realize its expansionary potential, these lessons seem to have been ignored in recent discussions of how to revitalize mature...

  11. Current and future alternative therapies for beta-thalassemia major.

    Science.gov (United States)

    de Dreuzy, Edouard; Bhukhai, Kanit; Leboulch, Philippe; Payen, Emmanuel

    2016-02-01

    Beta-thalassemia is a group of frequent genetic disorders resulting in the synthesis of little or no β-globin chains. Novel approaches are being developed to correct the resulting α/β-globin chain imbalance, in an effort to move beyond the palliative management of this disease and the complications of its treatment (e.g. life-long red blood cell transfusion, iron chelation, splenectomy), which impose high costs on healthcare systems. Three approaches are envisaged: fetal globin gene reactivation by pharmacological compounds injected into patients throughout their lives, allogeneic hematopoietic stem cell transplantation (HSCT), and gene therapy. HSCT is currently the only treatment shown to provide an effective, definitive cure for β-thalassemia. However, this procedure remains risky and histocompatible donors are identified for only a small fraction of patients. New pharmacological compounds are being tested, but none has yet made it into common clinical practice for the treatment of beta-thalassemia major. Gene therapy is in the experimental phase. It is emerging as a powerful approach without the immunological complications of HSCT, but with other possible drawbacks. Rapid progress is being made in this field, and long-term efficacy and safety studies are underway. Copyright © 2016 Chang Gung University. Published by Elsevier B.V. All rights reserved.

  12. Current and future alternative therapies for beta-thalassemia major

    Directory of Open Access Journals (Sweden)

    Edouard de Dreuzy

    2016-02-01

    Full Text Available Beta-thalassemia is a group of frequent genetic disorders resulting in the synthesis of little or no β-globin chains. Novel approaches are being developed to correct the resulting α/β-globin chain imbalance, in an effort to move beyond the palliative management of this disease and the complications of its treatment (e.g. life-long red blood cell transfusion, iron chelation, splenectomy, which impose high costs on healthcare systems. Three approaches are envisaged: fetal globin gene reactivation by pharmacological compounds injected into patients throughout their lives, allogeneic hematopoietic stem cell transplantation (HSCT, and gene therapy. HSCT is currently the only treatment shown to provide an effective, definitive cure for β-thalassemia. However, this procedure remains risky and histocompatible donors are identified for only a small fraction of patients. New pharmacological compounds are being tested, but none has yet made it into common clinical practice for the treatment of beta-thalassemia major. Gene therapy is in the experimental phase. It is emerging as a powerful approach without the immunological complications of HSCT, but with other possible drawbacks. Rapid progress is being made in this field, and long-term efficacy and safety studies are underway.

  13. Solar central receiver hybrid - A cost effective future power alternative

    Science.gov (United States)

    Beshore, D. G.; Bolton, C. N.; Montague, J. E.

    1980-05-01

    System analyses and conceptual designs of solar central receiver hybrid concepts using molten salt (60% NaNO3, 40% KNO3 by weight) and fossil fired nonsolar energy sources (coal, oil, or gas) have been performed. Analyses have developed plant configurations with various solar energy storage capacities and fossil fuels. Economic analyses support the final configuration selection based on minimization of the cost of energy produced from the plant. A 500 MWe commercial plant size installed for a 1990 initial year of operation is competitive with new coal, oil, and nuclear power generation sources. This hybrid plant will save an estimated 5 million barrels of oil per year.

  14. The Army’s Future Combat Systems Program and Alternatives

    Science.gov (United States)

    2006-08-01

    several different models of each type of vehi- cle—three models for the Abrams tank and for the Brad- ley fighting vehicle and two for the M113 and...Logistics, and Equipment Vehicle 90 Small Unmanned Ground Vehicle 81 Class I 54/108 Class II 36/36 Class III 12/48 Class IVa 2/8 Class IVb 8/16...page 38). According to the Army’s latest schedule, FCS vehicles could conceivably replace all of the Abrams tanks, Brad- ley fighting vehicles, self

  15. Maritime Prepositioning Force (Future) Capability Assessment: Planned and Alternative Structures

    Science.gov (United States)

    2010-01-01

    could interface more closely with the LCACs, either by directly offloading onto the hovercraft themselves or by transload- ing supplies from T-AKE to MLP... hovercraft that can load personnel, supplies, and equipment at the sea base and deliver them to the beach) are launched at a distance of 25 NM from the...aboard the MPF(F) be capable of moving ashore in one period of darkness. To a large extent, that requirement drives the need for the 18 hovercraft

  16. Energy Scenarios For A Sustainable Future

    Directory of Open Access Journals (Sweden)

    Ion Chiuta

    2008-05-01

    Full Text Available It is clear that the future is not simplysomething already predetermined that we must acceptblindly: rather, it is open and to a large extent determinedby the course of actions we decide to take. For thisreason, we need to look at the future and its uncertaintiesin an articulated fashion, developing specific tools toconsider both how the future might unfold if we do notact and how we might like the future to unfold if actionwere to be taken.As demonstrated on valuable intellectual exercise forlooking into an uncertain future involves the developmentof “scenarios” intended as logical and plausibleconjectures about how fundamental drivers will affectglobal societies, economics, resource use and theenvironment. The literature review shows a multiplicity ofscenarios, conducted as different scales ranging from thenational to the global scale, with different time horizonsand with a focus on different strategic issues.Exploratory scenarios help prepare for events that,without representing a straight-line continuation of pasttrends, are plausible and entirely possible. Exploratoryscenarios can help a lot to accelerate and calibrate theresponse to new developments, as well as providing astrategic framework technology development policy.Normative scenario has, as its goal, the evolution of adesirable future rather than a future inexorably imposedupon us by the inertia of system. Building a normativescenario requires the creators to clearly define thedesirable characteristics of their future, and to expressthis future in terms of measurable targets.The use of such a scenario process lies as much in theissues it requires us to comfort as the precise details isgenerates. The future will not look exactly like the oneenvisioned: other priorities will intercede and nationalconditions and circumstances will dictate the specifics ofthe energy policies that may be adopted. But such aprocess of interacting around scenarios can providevaluable guidance as to

  17. Coding potential of the products of alternative splicing in human.

    KAUST Repository

    Leoni, Guido

    2011-01-20

    BACKGROUND: Analysis of the human genome has revealed that as much as an order of magnitude more of the genomic sequence is transcribed than accounted for by the predicted and characterized genes. A number of these transcripts are alternatively spliced forms of known protein coding genes; however, it is becoming clear that many of them do not necessarily correspond to a functional protein. RESULTS: In this study we analyze alternative splicing isoforms of human gene products that are unambiguously identified by mass spectrometry and compare their properties with those of isoforms of the same genes for which no peptide was found in publicly available mass spectrometry datasets. We analyze them in detail for the presence of uninterrupted functional domains, active sites as well as the plausibility of their predicted structure. We report how well each of these strategies and their combination can correctly identify translated isoforms and derive a lower limit for their specificity, that is, their ability to correctly identify non-translated products. CONCLUSIONS: The most effective strategy for correctly identifying translated products relies on the conservation of active sites, but it can only be applied to a small fraction of isoforms, while a reasonably high coverage, sensitivity and specificity can be achieved by analyzing the presence of non-truncated functional domains. Combining the latter with an assessment of the plausibility of the modeled structure of the isoform increases both coverage and specificity with a moderate cost in terms of sensitivity.

  18. Future Summary

    CERN Document Server

    Wilczek, Frank

    2001-01-01

    We are emerging from a period of consolidation in particle physics. Its great, historic achievement was to establish the Theory of Matter. This Theory will serve as our description of ordinary matter under ordinary conditions -- allowing for an extremely liberal definition of "ordinary -- for the foreseeable future. Yet there are many indications, ranging from the numerical to the semi-mystical, that a new fertile period lies before us. We will discover compelling evidence for the unification of fundamental forces and for new quantum dimensions (low-energy supersymmetry). We will identify new forms of matter, which dominate the mass density of the Universe. We will achieve much better fundamental understanding of the behavior of matter in extreme astrophysical and cosmological environments. Lying beyond these expectations, we can identify deep questions that seem to call for ideas outside our present grasp. And there's still plenty of room for surprises.

  19. Future Summary

    Science.gov (United States)

    Wilczek, Frank

    We are emerging from a period of consolidation in particle physics. Its great, historic achievement was to establish the Theory of Matter. This Theory will serve as our description of ordinary matter under ordinary conditions - allowing for an extremely liberal definition of ``ordinary'' - for the foreseeable future. Yet there are many indications, ranging from the numerical to the semimystical, that a new fertile period lies before us. We will discover compelling evidence for the unification of fundamental forces and for new quantum dimensions (low-energy supersymmetry). We will identify new forms of matter, which dominate the mass density of the Universe. We will achieve much better fundamental understanding of the behavior of matter in extreme astrophysical and cosmological environments. Lying beyond these expectations, we can identify deep questions that seem to call for ideas outside our present grasp. And there is still plenty of room for surprises.

  20. Future Talks,

    Directory of Open Access Journals (Sweden)

    Catherine Defeyt

    2010-11-01

    Full Text Available La conservation des matériaux modernes et les difficultés qui la caractérisent étaient l’objet du colloque international Future Talks, organisé par Die Neue Sammlung, The International Design Museum, les 22 et 23 octobre 2009 à Munich. Conservateurs-restaurateurs spécialisés, représentants des  institutions muséales les plus prestigieuses d’Europe et d’outre-Atlantique ainsi que chercheurs en sciences appliquées y ont présenté leurs travaux et recherches. En matière de design, d’art moderne e...

  1. Promoting Scientific Thinking and Conceptual Change about Alternative Explanations of Climate Change and Other Controversial Socio-scientific Topics

    Science.gov (United States)

    Lombardi, D.; Sinatra, G. M.

    2013-12-01

    Critical evaluation and plausibility reappraisal of scientific explanations have been underemphasized in many science classrooms (NRC, 2012). Deep science learning demands that students increase their ability to critically evaluate the quality of scientific knowledge, weigh alternative explanations, and explicitly reappraise their plausibility judgments. Therefore, this lack of instruction about critical evaluation and plausibility reappraisal has, in part, contributed to diminished understanding about complex and controversial topics, such as global climate change. The Model-Evidence Link (MEL) diagram (originally developed by researchers at Rutgers University under an NSF-supported project; Chinn & Buckland, 2012) is an instructional scaffold that promotes students to critically evaluate alternative explanations. We recently developed a climate change MEL and found that the students who used the MEL experienced a significant shift in their plausibility judgments toward the scientifically accepted model of human-induced climate change. Using the MEL for instruction also resulted in conceptual change about the causes of global warming that reflected greater understanding of fundamental scientific principles. Furthermore, students sustained this conceptual change six months after MEL instruction (Lombardi, Sinatra, & Nussbaum, 2013). This presentation will discuss recent educational research that supports use of the MEL to promote critical evaluation, plausibility reappraisal, and conceptual change, and also, how the MEL may be particularly effective for learning about global climate change and other socio-scientific topics. Such instruction to develop these fundamental thinking skills (e.g., critical evaluation and plausibility reappraisal) is demanded by both the Next Generation Science Standards (Achieve, 2013) and the Common Core State Standards for English Language Arts and Mathematics (CCSS Initiative-ELA, 2010; CCSS Initiative-Math, 2010), as well as a

  2. Bipolar-pulses observed by the LRS/WFC-L onboard KAGUYA - Plausible evidence of lunar dust impact -

    Science.gov (United States)

    Kasahara, Yoshiya; Horie, Hiroki; Hashimoto, Kozo; Omura, Yoshiharu; Goto, Yoshitaka; Kumamoto, Atsushi; Ono, Takayuki; Tsunakawa, Hideo; Lrs/Wfc Team; Map/Lmag Team

    2010-05-01

    same) and thus most of bipolar-pulses which can be detected in MONO mode are cancelled in DIFF mode. This fact suggests that these bipolar pulses are not a kind of natural wave but these are caused by instantaneous potential changes of the KAGUYA spacecraft. Discussion: Similar type of bipolar-pulses has been observed by the monopole antenna measurements using Radio and Plasma Wave Science (RPWS) instruments on-board Cassini around Saturn [4]. They demonstrated that these bipolar pulses are caused by impacts of dusts floating around the Saturn. It is well-known that lunar dusts are widely dis-tributed in higher altitude range around the moon and it is plausible that these bipolar pulses are caused by the lunar dust impacts. In the presentation, we show the detailed charac-teristics of bipolar pulses detected by the WFC-L onboard KAGUYA. References: [1] Y. Kasahara et al., Earth, Planets and Space, 60(4), 341-351, 2008. [2] T. Ono et al., Earth, Planets and Space, 60(4), 321-332, 2008. [3] K. Hashimoto et al., The 4th SELENE (KAGUYA) Science Working Team Meeting, (this issue), 2010. [4] W.S. Kurth et al, Planetary and Space Science, 54(9-10), 988-998, 2006.

  3. Alternative Solar Indices

    Energy Technology Data Exchange (ETDEWEB)

    Lantz, L.J.

    1980-07-01

    Possible alternative Solar Indices which could either be a perturbation from the currently defined Solar Index or possible indices based on current technologies for other media markets are discussed. An overview is given of the current project, including the logic that was utilized in defining its current structure and then alternative indices and definitions are presented and finally, recommendations are made for adopting alternative indices.

  4. On alternating quantum walks

    Science.gov (United States)

    Rousseva, Jenia; Kovchegov, Yevgeniy

    2017-03-01

    We study an inhomogeneous quantum walk on a line that evolves according to alternating coins, each a rotation matrix. For the quantum walk with the coin alternating between clockwise and counterclockwise rotations by the same angle, we derive a closed form solution for the propagation of probabilities, and provide its asymptotic approximation via the method of stationary phase. Finally, we observe that for a x03c0;/4 angle, this alternating rotation walk will replicate the renown Hadamard walk.

  5. On an Alternative Cosmology

    CERN Document Server

    Vankov, A

    1998-01-01

    The suggested alternative cosmology is based on the idea of barion symmetric universe, in which our home universe is a representative of multitude of typical matter and antimatter universes. This alternative concept gives a physically reasonable explanation of all major problems of the Standard Cosmological Model. Classification Code MSC: Cosmology 524.8 Key words: standard cosmological model, alternative cosmology, barionic symmetry, typical universe, quasars, cosmic rays.

  6. Alternative medicine studies

    National Research Council Canada - National Science Library

    2011-01-01

    A peer-reviewed, open-access journal about alternative medicine systems including acupuncture, anthroposophic medicine, ayurveda, chiropractic, herbalism and natural products, homeopathy, naturopathy...

  7. Alternative Auditing Approaches

    Energy Technology Data Exchange (ETDEWEB)

    Kandt, Alicen J [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-09-15

    This presentation for the 2017 Energy Exchange in Tampa, Florida, offers information about advanced auditing technologies and techniques including alternative auditing approaches and considerations and caveats.

  8. Brandmodstandsbidrag for alternative isoleringsmaterialer

    DEFF Research Database (Denmark)

    Hansen, Ernst Jan de Place

    2001-01-01

    Resume af rapport om alternative isoleringsmaterialers brandmodstandsbidrag, udarbejdet af Dansk Brandteknisk Institut under Energistyrelsens udviklingsprogram "Miljø- og arbejdsmiljøvenlig isolering"...

  9. Land-use impacts on water resources and protected areas: applications of state-and-transition simulation modeling of future scenarios

    Science.gov (United States)

    Wilson, Tamara; Sleeter, Benjamin M.; Sherba, Jason T; Dick Cameron,

    2015-01-01

    Human land use will increasingly contribute to habitat loss and water shortages in California, given future population projections and associated land-use demand. Understanding how land-use change may impact future water use and where existing protected areas may be threatened by land-use conversion will be important if effective, sustainable management approaches are to be implemented. We used a state-and-transition simulation modeling (STSM) framework to simulate spatially-explicit (1 km2) historical (1992-2010) and future (2011-2060) land-use change for 52 California counties within Mediterranean California ecoregions. Historical land use and land cover (LULC) change estimates were derived from the Farmland Mapping and Monitoring Program dataset and attributed with county-level agricultural water-use data from the California Department of Water Resources. Five future alternative land-use scenarios were developed and modeled using the historical land-use change estimates and land-use projections based on the Intergovernmental Panel on Climate Change's Special Report on Emission Scenarios A2 and B1 scenarios. Spatial land-use transition outputs across scenarios were combined to reveal scenario agreement and a land conversion threat index was developed to evaluate vulnerability of existing protected areas to proximal land conversion. By 2060, highest LULC conversion threats were projected to impact nearly 10,500 km2 of land area within 10 km of a protected area boundary and over 18,000 km2 of land area within essential habitat connectivity areas. Agricultural water use declined across all scenarios perpetuating historical drought-related land use from 2008-2010 and trends of annual cropland conversion into perennial woody crops. STSM is useful in analyzing land-use related impacts on water resource use as well as potential threats to existing protected land. Exploring a range of alternative, yet plausible, LULC change impacts will help to better inform resource

  10. Land-use impacts on water resources and protected areas: applications of state-and-transition simulation modeling of future scenarios

    Directory of Open Access Journals (Sweden)

    Tamara S. Wilson

    2015-04-01

    Full Text Available Human land use will increasingly contribute to habitat loss and water shortages in California, given future population projections and associated land-use demand. Understanding how land-use change may impact future water use and where existing protected areas may be threatened by land-use conversion will be important if effective, sustainable management approaches are to be implemented. We used a state-and-transition simulation modeling (STSM framework to simulate spatially-explicit (1 km2 historical (1992‒2010 and future (2011‒2060 land-use change for 52 California counties within Mediterranean California ecoregions. Historical land use and land cover (LULC change estimates were derived from the Farmland Mapping and Monitoring Program dataset and attributed with county-level agricultural water-use data from the California Department of Water Resources. Five future alternative land-use scenarios were developed and modeled using the historical land-use change estimates and land-use projections based on the Intergovernmental Panel on Climate Change’s Special Report on Emission Scenarios A2 and B1 scenarios. Spatial land-use transition outputs across scenarios were combined to reveal scenario agreement and a land conversion threat index was developed to evaluate vulnerability of existing protected areas to proximal land conversion. By 2060, highest LULC conversion threats were projected to impact nearly 10,500 km2 of land area within 10 km of a protected area boundary and over 18,000 km2 of land area within essential habitat connectivity areas. Agricultural water use declined across all scenarios perpetuating historical drought-related land use from 2008‒2010 and trends of annual cropland conversion into perennial woody crops. STSM is useful in analyzing land-use related impacts on water resource use as well as potential threats to existing protected land. Exploring a range of alternative, yet plausible, LULC change impacts will help to

  11. Future food.

    Science.gov (United States)

    Wahlqvist, Mark L

    2016-12-01

    Food systems have changed markedly with human settlement and agriculture, industrialisation, trade, migration and now the digital age. Throughout these transitions, there has been a progressive population explosion and net ecosystem loss and degradation. Climate change now gathers pace, exacerbated by ecological dysfunction. Our health status has been challenged by a developing people-environment mismatch. We have regarded ecological conquest and innovative technology as solutions, but have not understood how ecologically dependent and integrated we are. We are ecological creatures interfaced by our sensoriness, microbiomes, shared regulatory (endocrine) mechanisms, immune system, biorhythms and nutritional pathways. Many of us are 'nature-deprived'. We now suffer what might be termed ecological health disorders (EHD). If there were less of us, nature's resilience might cope, but more than 9 billion people by 2050 is probably an intolerable demand on the planet. Future food must increasingly take into account the pressures on ecosystem-dependent food systems, with foods probably less biodiverse, although eating in this way allows optimal health; energy dysequilibrium with less physical activity and foods inappropriately energy dense; and less socially-conducive food habits. 'Personalised Nutrition', with extensive and resource-demanding nutrigenomic, metabolomic and microbiomic data may provide partial health solutions in clinical settings, but not be justified for ethical, risk management or sustainability reasons in public health. The globally prevalent multidimensional malnutritional problems of food insecurity, quality and equity require local, regional and global action to prevent further ecosystem degradation as well as to educate, provide sustainable livelihoods and encourage respectful social discourse and practice about the role of food.

  12. Alternative health insurance schemes

    DEFF Research Database (Denmark)

    Keiding, Hans; Hansen, Bodil O.

    2002-01-01

    In this paper, we present a simple model of health insurance with asymmetric information, where we compare two alternative ways of organizing the insurance market. Either as a competitive insurance market, where some risks remain uninsured, or as a compulsory scheme, where however, the level...... competitive insurance; this situation turns out to be at least as good as either of the alternatives...

  13. Acquisition of Voicing Alternations

    NARCIS (Netherlands)

    Kerkhoff, Annemarie

    2004-01-01

    "Morpho-phonological alternations are central to phonological theory, but little is known about how they are acquired. Acquiring alternations amounts to dealing with variation in a morpheme’s shape depending on its morphological context. It is generally assumed that children start with an initial st

  14. Alternative Schools, Mainstream Education

    Science.gov (United States)

    McKee, Jan; Conner, Evguenia

    2007-01-01

    Alternative education has its own history. Having emerged in the sixties as a response to the social crisis, its goal was primarily to fight increasing bureaucracy and the depersonalization of public education by giving students more freedom and minimal adult supervision. In the eighties, the understanding of "alternative education" narrowed to…

  15. Alternative Fuels Data Center

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-06-01

    Fact sheet describes the Alternative Fuels Data Center, which provides information, data, and tools to help fleets and other transportation decision makers find ways to reduce petroleum consumption through the use of alternative and renewable fuels, advanced vehicles, and other fuel-saving measures.

  16. Future: Solar energy. Zukunft: Sonnenenergie

    Energy Technology Data Exchange (ETDEWEB)

    Lange, V.

    1987-01-01

    The first chapter, 'Solar energy - more than just Utopia' deals with the following: Alternatives to nuclear energy problems of energy supply, solar energy use, commencement of the solar age in space, solar technology in the Federal Republic of Germany, solar collectors, wind power, energy from hydrogen. The second chapter 'Solar energy - its contribution to future energy supply' discusses prospects for the future (interviews with scientists and engineers). The third and last chapter gives practical hints (solar energy use: self-construction of solar plants). (HWJ).

  17. Contemplating the Future: Higher Education in the Context of Society.

    Science.gov (United States)

    Barksdale, Milton Kendall

    The relationship between higher education and society is explored. Consideration is given to definitions and models of futurism; alternative futures for society; trends and alternatives in education; the value of higher education; enrollment projections; financial issues; authority and control issues; the institutions; the students; the faculty;…

  18. Evidence for an implicit influence of memory on future thinking.

    Science.gov (United States)

    Szpunar, Karl K

    2010-07-01

    The capacity to think about specific events that one might encounter in the future--episodic future thought--involves the flexible (re)organization of memory. The present study demonstrates that implicit processes play an important role here. In two experiments (N = 180), participants were asked to generate a personal event that they expected to plausibly occur in the following week. The content of the participants' responses was biased (i.e., primed) by recent thoughts about a specific category of experiences. For instance, participants who had recently been induced to think about social experiences, in the context of an ostensibly unrelated task, were more likely than nonprimed participants to generate similar events occurring in their immediate future. Importantly, the participants were unaware of this unintentional influence of memory. The theoretical and practical implications of these findings for understanding episodic future thought and its relation to memory are discussed.

  19. Nearest shrunken centroids via alternative genewise shrinkages

    Science.gov (United States)

    Choi, Byeong Yeob; Bair, Eric; Lee, Jae Won

    2017-01-01

    Nearest shrunken centroids (NSC) is a popular classification method for microarray data. NSC calculates centroids for each class and “shrinks” the centroids toward 0 using soft thresholding. Future observations are then assigned to the class with the minimum distance between the observation and the (shrunken) centroid. Under certain conditions the soft shrinkage used by NSC is equivalent to a LASSO penalty. However, this penalty can produce biased estimates when the true coefficients are large. In addition, NSC ignores the fact that multiple measures of the same gene are likely to be related to one another. We consider several alternative genewise shrinkage methods to address the aforementioned shortcomings of NSC. Three alternative penalties were considered: the smoothly clipped absolute deviation (SCAD), the adaptive LASSO (ADA), and the minimax concave penalty (MCP). We also showed that NSC can be performed in a genewise manner. Classification methods were derived for each alternative shrinkage method or alternative genewise penalty, and the performance of each new classification method was compared with that of conventional NSC on several simulated and real microarray data sets. Moreover, we applied the geometric mean approach for the alternative penalty functions. In general the alternative (genewise) penalties required fewer genes than NSC. The geometric mean of the class-specific prediction accuracies was improved, as well as the overall predictive accuracy in some cases. These results indicate that these alternative penalties should be considered when using NSC. PMID:28199352

  20. HL-LHC alternatives

    CERN Document Server

    Tomás, R; White, S

    2014-01-01

    The HL-LHC parameters assume unexplored regimes for hadron colliders in various aspects of accelerator beam dynamics and technology. This paper reviews three alternatives that could potentially improve the LHC performance: (i) the alternative filling scheme 8b+4e, (ii) the use of a 200 MHz RF system in the LHC and (iii) the use of proton cooling methods to reduce the beam emittance (at top energy and at injection). The alternatives are assessed in terms of feasibility, pros and cons, risks versus benefits and the impact on beam availability.

  1. Alternative loop rings

    CERN Document Server

    Goodaire, EG; Polcino Milies, C

    1996-01-01

    For the past ten years, alternative loop rings have intrigued mathematicians from a wide cross-section of modern algebra. As a consequence, the theory of alternative loop rings has grown tremendously. One of the main developments is the complete characterization of loops which have an alternative but not associative, loop ring. Furthermore, there is a very close relationship between the algebraic structures of loop rings and of group rings over 2-groups. Another major topic of research is the study of the unit loop of the integral loop ring. Here the interaction between loop rings and group ri

  2. Vaginal dryness alternative treatments

    Science.gov (United States)

    Alternative treatments for vaginal dryness ... Question: Is there a drug-free treatment for vaginal dryness? Answer: There are many causes of vaginal dryness . It may be caused by reduced estrogen level, infection, medicines, and ...

  3. Breast Reconstruction Alternatives

    Science.gov (United States)

    ... Breast Reconstruction Surgery Breast Cancer Breast Reconstruction Surgery Breast Reconstruction Alternatives Some women who have had a ... chest. What if I choose not to get breast reconstruction? Some women decide not to have any ...

  4. Alternative disinfectant water treatments

    Science.gov (United States)

    Alternative disinfestant water treatments are disinfestants not as commonly used by the horticultural industry. Chlorine products that produce hypochlorous acid are the main disinfestants used for treating irrigation water. Chlorine dioxide will be the primary disinfestant discussed as an alternativ...

  5. Seal design alternatives study

    Energy Technology Data Exchange (ETDEWEB)

    Van Sambeek, L.L. [RE/SPEC Inc., Rapid City, SD (US); Luo, D.D.; Lin, M.S.; Ostrowski, W.; Oyenuga, D. [Parsons Brinckerhoff Quade & Douglas, Inc., San Francisco, CA (US)

    1993-06-01

    This report presents the results from a study of various sealing alternatives for the WIPP sealing system. Overall, the sealing system has the purpose of reducing to the extent possible the potential for fluids (either gas or liquid) from entering or leaving the repository. The sealing system is divided into three subsystems: drift and panel seals within the repository horizon, shaft seals in each of the four shafts, and borehole seals. Alternatives to the baseline configuration for the WIPP seal system design included evaluating different geometries and schedules for seal component installations and the use of different materials for seal components. Order-of-magnitude costs for the various alternatives were prepared as part of the study. Firm recommendations are not presented, but the advantages and disadvantages of the alternatives are discussed. Technical information deficiencies are identified and studies are outlined which can provide required information.

  6. Alternative fuel information sources

    Energy Technology Data Exchange (ETDEWEB)

    1994-06-01

    This short document contains a list of more than 200 US sources of information (Name, address, phone number, and sometimes contact) related to the use of alternative fuels in automobiles and trucks. Electric-powered cars are also included.

  7. A Comparison of State Alternative Education Accountability Policies and Frameworks

    Science.gov (United States)

    Schlessman, Amy; Hurtado, Kelly

    2012-01-01

    The purpose of this policy study was to report descriptive research on state-level policy and frameworks for accountability systems of alternative education in the United States. The six states; California, Colorado, Texas, Florida, Oklahoma, and North Carolina; identified in the 2010 Jobs for the Futures policy analysis of alternative education…

  8. One-pot synthesis of tetrazole-1,2,5,6-tetrahydronicotinonitriles and cholinesterase inhibition: Probing the plausible reaction mechanism via computational studies.

    Science.gov (United States)

    Hameed, Abdul; Zehra, Syeda Tazeen; Abbas, Saba; Nisa, Riffat Un; Mahmood, Tariq; Ayub, Khurshid; Al-Rashida, Mariya; Bajorath, Jürgen; Khan, Khalid Mohammed; Iqbal, Jamshed

    2016-04-01

    In the present study, one-pot synthesis of 1H-tetrazole linked 1,2,5,6-tetrahydronicotinonitriles under solvent-free conditions have been carried out in the presence of tetra-n-butyl ammonium fluoride trihydrated (TBAF) as catalyst and solvent. Computational studies have been conducted to elaborate two plausible mechanistic pathways of this one-pot reaction. Moreover, the synthesized compounds were screened for cholinesterases (acetylcholinesterase and butyrylcholinesterase) inhibition which are consider to be major malefactors of Alzheimer's disease (AD) to find lead compounds for further research in AD therapy.

  9. Phylogenetic analysis of NS5B gene of classical swine fever virus isolates indicates plausible Chinese origin of Indian subgroup 2.2 viruses.

    Science.gov (United States)

    Patil, S S; Hemadri, D; Veeresh, H; Sreekala, K; Gajendragad, M R; Prabhudas, K

    2012-02-01

    Twenty-three CSFV isolates recovered from field outbreaks in various parts of India during 2006-2009 were used for genetic analysis in the NS5B region (409 nts). Seventeen of these were studied earlier [16] in the 5'UTR region. Phylogenetic analysis indicated the continued dominance of subgroup 1.1 strains in the country. Detailed analysis of a subgroup 2.2 virus indicated the plausible Chinese origin of this subgroup in India and provided indirect evidence of routes of CSFV movement within South East Asia region.

  10. Evaluating the economy of alternative energies to petroleum

    Energy Technology Data Exchange (ETDEWEB)

    Mitate, H.

    1982-01-01

    An account is given of the present state of the use of alternative energies to petroleum. This is followed by descriptions of current economic evaluations of such energies (energy choice and economy, cost analysis of alternative energy use) and of future tasks for economic evaluations (international comparisons of energy prices, comprehensive evaluations of alternative energies and economic evaluations of new energy technologies.) (1 ref.) (In Japanese)

  11. ALTERNATIVE FUELS AND CHEMICALS FROM SYNTHESIS GAS

    Energy Technology Data Exchange (ETDEWEB)

    Peter Tijrn

    2003-02-03

    The overall objectives of this program are to investigate potential technologies for the conversion of synthesis gas to oxygenated and hydrocarbon fuels and industrial chemicals, and to demonstrate the most promising technologies at DOE's LaPorte, Texas, Slurry Phase Alternative Fuels Development Unit (AFDU). The program will involve a continuation of the work performed under the Alternative Fuels from Coal-Derived Synthesis Gas Program and will draw upon information and technologies generated in parallel current and future DOE-funded contracts.

  12. Alternative types of roundabouts an informational guide

    CERN Document Server

    Tollazzi, Tomaž

    2015-01-01

    This book presents a history of roundabouts, an introduction to their design, calculations of their capacity and traffic-safety features. It describes the key features of standard roundabouts and their limitations. Alternative types of roundabouts are a fairly recent development and have only been implemented in a few countries to date. The book illustrates a broad variety of these recent alternative types of roundabouts, as well as proposed types still in the development phase, explaining for each the specific needs it meets, its advantages and drawbacks. In closing, the book offers an outlook on the role of roundabouts in future street traffic.

  13. Alternative Fuels and Chemicals from Synthesis Gas

    Energy Technology Data Exchange (ETDEWEB)

    Peter Tijrn

    2003-01-02

    The overall objectives of this program are to investigate potential technologies for the conversion of synthesis gas to oxygenated and hydrocarbon fuels and industrial chemicals, and to demonstrate the most promising technologies at DOE's LaPorte, Texas, Slurry Phase Alternative Fuels Development Unit (AFDU). The program will involve a continuation of the work performed under the Alternative Fuels from Coal-Derived Synthesis Gas Program and will draw upon information and technologies generated in parallel current and future DOE-funded contracts.

  14. ALTERNATIVE FUELS AND CHEMICALS FROM SYNTHESIS GAS

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    1999-01-01

    The overall objectives of this program are to investigate potential technologies for the conversion of synthesis gas to oxygenated and hydrocarbon fuels and industrial chemicals, and to demonstrate the most promising technologies at DOE's LaPorte, Texas, Slurry Phase Alternative Fuels Development Unit (AFDU). The program will involve a continuation of the work performed under the Alternative Fuels from Coal-Derived Synthesis Gas Program and will draw upon information and technologies generated in parallel current and future DOE-funded contracts.

  15. Alternative fuels and chemicals from synthesis gas

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    1998-08-01

    The overall objectives of this program are to investigate potential technologies for the conversion of synthesis gas to oxygenated and hydrocarbon fuels and industrial chemicals, and to demonstrate the most promising technologies at DOE's LaPorte, Texas, Slurry Phase Alternative Fuels Development Unit (AFDU). The program will involve a continuation of the work performed under the Alternative Fuels from Coal-Derived Synthesis Gas Program and will draw upon information and technologies generated in parallel current and future DOE-funded contracts.

  16. ALTERNATIVE FUELS AND CHEMICALS FROM SYNTHESIS GAS

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    1999-04-01

    The overall objectives of this program are to investigate potential technologies for the conversion of synthesis gas to oxygenated and hydrocarbon fuels and industrial chemicals, and to demonstrate the most promising technologies at DOE's LaPorte, Texas, Slurry Phase Alternative Fuels Development Unit (AFDU). The program will involve a continuation of the work performed under the Alternative Fuels from Coal-Derived Synthesis Gas Program and will draw upon information and technologies generated in parallel current and future DOE-funded contracts.

  17. Alternative fuels and chemicals from synthesis gas

    Energy Technology Data Exchange (ETDEWEB)

    Unknown

    1998-08-01

    The overall objectives of this program are to investigate potential technologies for the conversion of synthesis gas to oxygenated and hydrocarbon fuels and industrial chemicals, and to demonstrate the most promising technologies at DOE's LaPorte, Texas, Slurry Phase Alternative Fuels Development Unit (AFDU). The program will involve a continuation of the work performed under the Alternative Fuels from Coal-Derived Synthesis Gas Program and will draw upon information and technologies generated in parallel current and future DOE-funded contracts.

  18. Alternative Fuels and Chemicals from Synthesis Gas

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    1998-12-02

    The overall objectives of this program are to investigate potential technologies for the conversion of synthesis gas to oxygenated and hydrocarbon fuels and industrial chemicals, and to demonstrate the most promising technologies at DOE's LaPorte, Texas, Slurry Phase Alternative Fuels Development Unit (AFDU). The program will involve a continuation of the work performed under the Alternative Fuels from Coal-Derived Synthesis Gas Program and will draw upon information and technologies generated in parallel current and future DOE-funded contracts.

  19. Alternative Fuels and Chemicals From Synthesis Gas

    Energy Technology Data Exchange (ETDEWEB)

    none

    1998-07-01

    The overall objectives of this program are to investigate potential technologies for the conversion of synthesis gas to oxygenated and hydrocarbon fuels and industrial chemicals, and to demonstrate the most promising technologies at DOE's LaPorte, Texas, Slurry Phase Alternative Fuels Development Unit (AFDU). The program will involve a continuation of the work performed under the Alternative Fuels from Coal-Derived Synthesis Gas Program and will draw upon information and technologies generated in parallel current and future DOE-funded contracts.

  20. Fourier power, subjective distance and object categories all provide plausible models of BOLD responses in scene-selective visual areas

    Directory of Open Access Journals (Sweden)

    Mark Daniel Lescroart

    2015-11-01

    Full Text Available Perception of natural visual scenes activates several functional areas in the human brain, including the Parahippocampal Place Area (PPA, Retrosplenial Complex (RSC, and the Occipital Place Area (OPA. It is currently unclear what specific scene-related features are represented in these areas. Previous studies have suggested that PPA, RSC, and/or OPA might represent at least three qualitatively different classes of features: (1 2D features related to Fourier power; (2 3D spatial features such as the distance to objects in a scene; or (3 abstract features such as the categories of objects in a scene. To determine which of these hypotheses best describes the visual representation in scene-selective areas, we applied voxel-wise modeling (VM to BOLD fMRI responses elicited by a set of 1,386 images of natural scenes. VM provides an efficient method for testing competing hypotheses by comparing predictions of brain activity based on encoding models that instantiate each hypothesis. Here we evaluated three different encoding models that instantiate each of the three hypotheses listed above. We used linear regression to fit each encoding model to the fMRI data recorded from each voxel, and we evaluated each fit model by estimating the amount of variance it predicted in a withheld portion of the data set. We found that voxel-wise models based on Fourier power or the subjective distance to objects in each scene predicted much of the variance predicted by a model based on object categories. Furthermore, the response variance explained by these three models is largely shared, and the individual models explain little unique variance in responses. Based on an evaluation of previous studies and the data we present here, we conclude that there is currently no good basis to favor any one of the three alternative hypotheses about visual representation in scene-selective areas. We offer suggestions for further studies that may help resolve this issue.

  1. Habitat availability is a more plausible explanation than insecticide acute toxicity for U.S. grassland bird species declines.

    Science.gov (United States)

    Hill, Jason M; Egan, J Franklin; Stauffer, Glenn E; Diefenbach, Duane R

    2014-01-01

    Grassland bird species have experienced substantial declines in North America. These declines have been largely attributed to habitat loss and degradation, especially from agricultural practices and intensification (the habitat-availability hypothesis). A recent analysis of North American Breeding Bird Survey (BBS) "grassland breeding" bird trends reported the surprising conclusion that insecticide acute toxicity was a better correlate of grassland bird declines in North America from 1980-2003 (the insecticide-acute-toxicity hypothesis) than was habitat loss through agricultural intensification. In this paper we reached the opposite conclusion. We used an alternative statistical approach with additional habitat covariates to analyze the same grassland bird trends over the same time frame. Grassland bird trends were positively associated with increases in area of Conservation Reserve Program (CRP) lands and cropland used as pasture, whereas the effect of insecticide acute toxicity on bird trends was uncertain. Our models suggested that acute insecticide risk potentially has a detrimental effect on grassland bird trends, but models representing the habitat-availability hypothesis were 1.3-21.0 times better supported than models representing the insecticide-acute-toxicity hypothesis. Based on point estimates of effect sizes, CRP area and agricultural intensification had approximately 3.6 and 1.6 times more effect on grassland bird trends than lethal insecticide risk, respectively. Our findings suggest that preserving remaining grasslands is crucial to conserving grassland bird populations. The amount of grassland that has been lost in North America since 1980 is well documented, continuing, and staggering whereas insecticide use greatly declined prior to the 1990s. Grassland birds will likely benefit from the de-intensification of agricultural practices and the interspersion of pastures, Conservation Reserve Program lands, rangelands and other grassland habitats into

  2. Extrapolating future Arctic ozone losses

    Directory of Open Access Journals (Sweden)

    B. M. Knudsen

    2004-06-01

    Full Text Available Future increases in the concentration of greenhouse gases and water vapour are likely to cool the stratosphere further and to increase the amount of polar stratospheric clouds (PSCs. Future Arctic PSC areas have been extrapolated using the highly significant trends in the temperature record from 1958–2001. Using a tight correlation between PSC area and the total vortex ozone depletion and taking the decreasing amounts of ozone depleting substances into account we make empirical estimates of future ozone. The result is that Arctic ozone losses increase until 2010–2020 and only decrease slightly up to 2030. This approach is an alternative method of prediction to that based on the complex coupled chemistry-climate models (CCMs.

  3. Developing scenarios to assess future landslide risks: a model-based approach applied to mountainous regions

    Science.gov (United States)

    Vacquie, Laure; Houet, Thomas

    2016-04-01

    In the last century, European mountain landscapes have experienced significant transformations. Natural and anthropogenic changes, climate changes, touristic and industrial development, socio-economic interactions, and their implications in terms of LUCC (land use and land cover changes) have directly influenced the spatial organization and vulnerability of mountain landscapes. This study is conducted as part of the SAMCO project founded by the French National Science Agency (ANR). It aims at developing a methodological approach, combining various tools, modelling platforms and methods, to identify vulnerable regions to landslide hazards accounting for futures LUCC. It presents an integrated approach combining participative scenarios and a LULC changes simulation models to assess the combined effects of LUCC and climate change on landslide risks in the Cauterets valley (French Pyrenees Mountains) up to 2100. Through vulnerability and risk mapping, the objective is to gather information to support landscape planning and implement land use strategies with local stakeholders for risk management. Four contrasting scenarios are developed and exhibit contrasting trajectories of socio-economic development. Prospective scenarios are based on national and international socio-economic contexts relying on existing assessment reports. The methodological approach integrates knowledge from local stakeholders to refine each scenario during their construction and to reinforce their plausibility and relevance by accounting for local specificities, e.g. logging and pastoral activities, touristic development, urban planning, etc. A process-based model, the Forecasting Scenarios for Mountains (ForeSceM) model, developed on the Dinamica Ego modelling platform is used to spatially allocate futures LUCC for each prospective scenario. Concurrently, a spatial decision support tool, i.e. the SYLVACCESS model, is used to identify accessible areas for forestry in scenario projecting logging

  4. How will ocean acidification affect Baltic sea ecosystems? an assessment of plausible impacts on key functional groups.

    Science.gov (United States)

    Havenhand, Jonathan N

    2012-09-01

    Increasing partial pressure of atmospheric CO₂ is causing ocean pH to fall-a process known as 'ocean acidification'. Scenario modeling suggests that ocean acidification in the Baltic Sea may cause a ≤ 3 times increase in acidity (reduction of 0.2-0.4 pH units) by the year 2100. The responses of most Baltic Sea organisms to ocean acidification are poorly understood. Available data suggest that most species and ecologically important groups in the Baltic Sea food web (phytoplankton, zooplankton, macrozoobenthos, cod and sprat) will be robust to the expected changes in pH. These conclusions come from (mostly) single-species and single-factor studies. Determining the emergent effects of ocean acidification on the ecosystem from such studies is problematic, yet very few studies have used multiple stressors and/or multiple trophic levels. There is an urgent need for more data from Baltic Sea populations, particularly from environmentally diverse regions and from controlled mesocosm experiments. In the absence of such information it is difficult to envision the likely effects of future ocean acidification on Baltic Sea species and ecosystems.

  5. Alternative fuels for vehicles; Alternative drivmidler

    Energy Technology Data Exchange (ETDEWEB)

    2012-02-15

    Up until 2020 and onwards the analysis indicates that especially electricity, biogas and natural gas as propellants is economically attractive compared to conventional gasoline and diesel while other fuels have the same or higher costs for petrol and diesel. Especially biogas and electricity will also offer significant reductions in CO{sub 2} emissions, but also hydrogen, methanol, DME and to a lesser extent the second generation bioethanol and most of the other alternative fuels reduce CO{sub 2} emissions. Use of the traditional food-based first generation biofuels involves, at best, only modest climate benefits if land use changes are counted, and at worst, significant negative climate effects. Natural gas as a propellant involves a moderate climate gain, but may play a role for building infrastructure and market for gaseous fuels in large fleets, thereby contributing to the phasing in of biogas for transport. The electric-based automotive fuels are the most effective due to a high efficiency of the engine and an increasing proportion of wind energy in the electricity supply. The methanol track also has a relatively high efficiency. Among the others, the track based on diesel engines (biodiesel) is more effective than the track based on gasoline/Otto engines (gas and ethanol) as a result of the diesel engine's better efficiency. For the heavy vehicles all the selected alternative fuels to varying degrees reduce emissions of CO{sub 2}, particularly DME based on wood. The only exception to this is - as for passenger cars - the propellant synthetic diesel based on coal. (LN).

  6. Identification of the bkdAB gene cluster, a plausible source of the starter-unit for virginiamycin M production in Streptomyces virginiae.

    Science.gov (United States)

    Pulsawat, Nattika; Kitani, Shigeru; Kinoshita, Hiroshi; Lee, Chang Kwon; Nihira, Takuya

    2007-06-01

    The bkdAB gene cluster, which encodes plausible E1 and E2 components of the branched-chain alpha-keto acid dehydrogenase (BCDH) complex, was isolated from Streptomyces virginiae in the vicinity of a regulatory island for virginiamycin production. Gene disruption of bkdA completely abolished the production of virginiamycin M (a polyketide-peptide antibiotic), while the production of virginiamycin S (a cyclodepsipeptide antibiotic) was unaffected. Complementation of the bkdA disruptant by genome-integration of intact bkdA completely restored the virginiamycin M production, indicating that the bkdAB cluster is essential for virginiamycin M biosynthesis, plausibly via the provision of isobutyryl-CoA as a primer unit. In contrast to a feature usually seen in the Streptomyces E1 component, namely, the separate encoding of the alpha and beta subunits, S. virginiae bkdA seemed to encode the fused form of the alpha and beta subunits, which was verified by the actual catalytic activity of the fused protein in vitro using recombinant BkdA overexpressed in Escherichia coli. Supply of an additional bkdA gene under the strong and constitutive promoter ermE* in the wild-type strain of S. virginiae resulted in enhanced production of virginiamycin M, suggesting that the supply of isobutyryl-CoA is one of the rate-limiting factors in the biosynthesis of virginiamycin M.

  7. Analysis of multi-domain hypothetical proteins containing iron-sulphur clusters and fad ligands reveal rieske dioxygenase activity suggesting their plausible roles in bioremediation.

    Science.gov (United States)

    Sathyanarayanan, Nitish; Nagendra, Holenarasipur Gundurao

    2012-01-01

    'Conserved hypothetical' proteins pose a challenge not just for functional genomics, but also to biology in general. As long as there are hundreds of conserved proteins with unknown function in model organisms such as Escherichia coli, Bacillus subtilis or Saccharomyces cerevisiae, any discussion towards a 'complete' understanding of these biological systems will remain a wishful thinking. Insilico approaches exhibit great promise towards attempts that enable appreciating the plausible roles of these hypothetical proteins. Among the majority of genomic proteins, two-thirds in unicellular organisms and more than 80% in metazoa, are multi-domain proteins, created as a result of gene duplication events. Aromatic ring-hydroxylating dioxygenases, also called Rieske dioxygenases (RDOs), are class of multi-domain proteins that catalyze the initial step in microbial aerobic degradation of many aromatic compounds. Investigations here address the computational characterization of hypothetical proteins containing Ferredoxin and Flavodoxin signatures. Consensus sequence of each class of oxidoreductase was obtained by a phylogenetic analysis, involving clustering methods based on evolutionary relationship. A synthetic sequence was developed by combining the consensus, which was used as the basis to search for their homologs via BLAST. The exercise yielded 129 multidomain hypothetical proteins containing both 2Fe-2S (Ferredoxin) and FNR (Flavodoxin) domains. In the current study, 40 proteins with N-terminus 2Fe-2S domain and C-terminus FNR domain are characterized, through homology modelling and docking exercises which suggest dioxygenase activity indicating their plausible roles in degradation of aromatic moieties.

  8. Emergent structured transition from variation to repetition in a biologically-plausible model of learning in basal ganglia.

    Directory of Open Access Journals (Sweden)

    Ashvin eShah

    2014-02-01

    Full Text Available Often, when animals encounter an unexpected sensory event, they transition from executing a variety of movements to repeating the movement(s that may have caused the event. According to a recent theory of action discovery (Redgrave and Gurney 2006, repetition allows the animal to represent those movements, and the outcome, as an action for later recruitment. The transition from variation to repetition often follows a non-random, structured, pattern. While the structure of the pattern can be explained by sophisticated cognitive mechanisms, simpler mechanisms based on dopaminergic modulation of basal ganglia (BG activity are thought to underlie action discovery (Redgrave and Gurney 2006. In this paper we ask the question: can simple BG-mediated mechanisms account for a structured transition from variation to repetition, or are more sophisticated cognitive mechanisms always necessary?To address this question, we present a computational model of BG-mediated biasing of behavior. In our model, unlike most other models of BG function, the BG biases behaviour through modulation of cortical response to excitation; many possible movements are represented by the cortical area; and excitation to the cortical area is topographically-organized. We subject the model to simple reaching tasks, inspired by behavioral studies, in which a location to which to reach must be selected. Locations within a target area elicit a reinforcement signal. A structured transition from variation to repetition emerges from simple BG-mediated biasing of cortical response to excitation. We show how the structured pattern influences behavior in simple and complicated tasks. We also present analyses that describe the structured transition from variation to repetition due to BG-mediated biasing and from biasing that would be expected from a type of cognitive biasing, allowing us to compare behaviour resulting from these types of biasing and make connections with future behavioural

  9. Alternative Green Solvents Project

    Science.gov (United States)

    Maloney, Phillip R.

    2012-01-01

    Necessary for safe and proper functioning of equipment. Mainly halogenated solvents. Tetrachloride, Trichloroethylene (TCE), CFC-113. No longer used due to regulatory/safety concerns. Precision Cleaning at KSC: Small % of total parts. Used for liquid oxygen (LOX) systems. Dual solvent process. Vertrel MCA (decafluoropentane (DFP) and trons-dichloroethylene) HFE-7100. DFP has long term environmental concerns. Project Goals: a) Identify potential replacements. b) 22 wet chemical processes. c) 3 alternative processes. d) Develop test procedures. e) Contamination and cleaning. f) Analysis. g) Use results to recommend alternative processes. Conclusions: a) No alternative matched Vertrel in this study. b) No clear second place solvent. c) Hydrocarbons- easy; Fluorinated greases- difficult. d) Fluorinated component may be needed in replacement solvent. e) Process may need to make up for shortcoming of the solvent. f) Plasma and SCC02 warrant further testing.

  10. Propofol alternatives in gastrointestinal endoscopy anesthesia

    Directory of Open Access Journals (Sweden)

    Basavana Gouda Goudra

    2014-01-01

    Full Text Available Although propofol has been the backbone for sedation in gastrointestinal endoscopy, both anesthesiologists and endoscopists are faced with situations where an alternative is needed. Recent national shortages forced many physicians to explore these options. A midazolam and fentanyl combination is the mainstay in this area. However, there are other options. The aim of this review is to explore these options. The future would be, invariably, to move away from propofol. The reason is not in any way related to the drawbacks of propofol as a sedative. The mandate that requires an anesthesia provider to administer propofol has been a setback in many countries. New sedative drugs like Remimazolam might fill this void in the future. In the meantime, it is important to keep an open eye to the existing alternatives.

  11. Catalysis for alternative energy generation

    CERN Document Server

    2012-01-01

    Summarizes recent problems in using catalysts in alternative energy generation and proposes novel solutions  Reconsiders the role of catalysis in alternative energy generation  Contributors include catalysis and alternative energy experts from across the globe

  12. [Alternative scaffold proteins].

    Science.gov (United States)

    Petrovskaia, L E; Shingarova, L N; Dolgikh, D A; Kirpichnikov, M P

    2011-01-01

    Review is devoted to the challenging direction in modem molecular biology and bioengineering - the properties of alternative scaffold proteins (ASP) and methods for obtaining ASP binding molecules. ASP molecules incorporate conservative protein core and hypervariable regions, providing for the binding function. Structural classification of ASP includes several types which differ also in their molecular targets and potential applications. Construction of artificial binding proteins on the ASP basis implies a combinatorial library design with subsequent selection of specific binders with the use of phage display or the modem cell-free systems. Alternative binding proteins on non-immunoglobulin scaffolds find broad applications in different fields ofbiotechnology and molecular medicine.

  13. The Alternative to Occupy?

    DEFF Research Database (Denmark)

    Husted, Emil; Hansen, Allan Dreyer

    2017-01-01

    In this paper, we compare the political anatomy of two distinct enactments of (leftist) radical politics: Occupy Wall Street, a large social movement in the United States, and The Alternative, a recently elected political party in Denmark. Based on Ernesto Laclau’s conceptualization of ‘the...... universal’ and ‘the particular’, we show how the institutionalization of radical politics (as carried out by The Alternative) entails a move from universality towards particularity. This move, however, comes with the risk of cutting off supporters who no longer feel represented by the project. We refer...

  14. The Alternative to Occupy

    DEFF Research Database (Denmark)

    Husted, Emil; Hansen, Allan Dreyer

    2017-01-01

    In this paper, we compare the political anatomy of two distinct enactments of (leftist) radical politics: Occupy Wall Street and The Alternative, a recently elected political party in Denmark. Departing from Ernesto Laclau’s conceptualization of ‘the universal’ and ‘the particular’, we show how...... the institutionalization of radical politics (as carried out by The Alternative) entails a move from universality towards particularity. This move, however, comes with the risk of cutting-off supporters who no longer feel represented by the project. We refer to this problem as ‘the problem of particularization...

  15. Future energy perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Halsnaes, K.; Christensen, J.M. [Risoe National Lab., Systems Analysis Dept., Roskilde (Denmark)

    2002-10-01

    Future energy perspectives: 1) The global energy consumption will continue to grow primarily in developing countries, their share of global energy consumption will grow from approx. 35% in 1990 to 60% in 2050. 2) Policy focus will be primarily on environmental concerns in the industrial countries and on energy for development and access to energy for the poor in developing countries. 3) With global climate concerns and the implementation of the Kyoto protocol, global environment issues will have increased prominence in energy sector priorities. 4) Fossil fuel resources are on a global level still abundant and prices are expected to be relatively low in the short to medium term. 5) Energy supply security has for geopolitical reasons become an increasing concern especially in the US and the EU. 6) Significant investments are required to ensure development of new clean energy technologies for introduction in the medium to long term. 7) Market reforms are being implemented in almost all regions of the world changing both the investment and policy regimes. 8) International studies (IPCC and WEC) have analysed several alternative energy scenarios Alternative policies and priorities can lead to a wide range of different energy futures. 9) WEC middle scenario B, from 1990 to 2050; predicts growth in GDP 3.5 times and primary energy consumption 2.2 times and CO{sub 2} 1.5 times. This scenario is expecting supply to be dominated by fossil fuel (80% in 1990 and still 65% in 2050), with high share of natural gas and nuclear with slow growth in renewable energy. 10) A more radical scenario (C1) is expecting renewable energy such as biomass, solar and wind to contribute 27% in 2050; declining oil and coal; increased use of natural gas and a minor contribution from nuclear. A development path like this require significant near-term investments in technology research and development. 11) The large increase in global energy demand in the next century will require large investments

  16. Biologic Joint Reconstruction: Alternatives to Arthroplasty

    OpenAIRE

    Cole, Brian J.; Andreas H. Gmoll

    2009-01-01

    A comprehensive source of information in the management of cartilage lesions of major joints using nonoperative or surgical techniques other than total joint replacement. The text also includes chapters in basic sciences, imaging and rehabilitation.The editors are aiming to provide a reference about the latest concepts and techniques in the treatment of cartilage lesions including future aspects by a comprehensive approach to the alternative joint restoration procedures such as biological, ph...

  17. Alternative Energy Busing

    Science.gov (United States)

    LaFee, Scott

    2012-01-01

    In recent years, school districts have converted portions of their bus fleets to cleaner-burning, sometimes cheaper, alternative fossil fuels, such as compressed natural gas or propane. Others have adopted biodiesel, which combines regular diesel with fuel derived from organic sources, usually vegetable oils or animal fats. The number of biodiesel…

  18. Alternate dispute resolution.

    OpenAIRE

    Webb, Paul F.

    1994-01-01

    In an effort to save taxpayer dollars and ease an overburdened administrative and judicial court system, this report presents evidence to encourage the use of alternate dispute resolution (ADR) in construction contracting within the Naval Facilities Engineering Command. Information is presented detailing the primary factors that contribute to this expensive and overburdened system, including: costs associated with litigation, contractual document formation, experience level ...

  19. Alternatives in solar energy

    Science.gov (United States)

    Schueler, D. G.

    1978-01-01

    Although solar energy has the potential of providing a significant source of clean and renewable energy for a variety of applications, it is expected to penetrate the nation's energy economy very slowly. The alternative solar energy technologies which employ direct collection and conversion of solar radiation as briefly described.

  20. Complementary and Alternative Medicine

    Science.gov (United States)

    ... the practitioner to ask about the risks and benefits of treatment — the same kinds of things you'd do if you were interviewing a new doctor. You may have already used a complementary or alternative practice, like yoga or massage, and not even thought about it! ...

  1. Environment and Alternative Development.

    Science.gov (United States)

    Kothari, Rajni

    Stressing the global dimension to the adversary relationship between economic development and environmental conservation, this monograph examines the philosophical, historical, cultural, and ethnic underpinnings of modern science and technology. In addition, the monograph spells out policy implications of an alternative concept of development and…

  2. A structural bridge between alternant and non-alternant hydrocarbons

    Directory of Open Access Journals (Sweden)

    Richard Francis Langler

    2001-06-01

    Full Text Available A simple set of trimethylene-substituted even, fully-pi-bonded, non-alternant monocycles is shown to have several key features in common with acyclic, even alternant polyenes at the Hückel level. These non-alternant molecules provide a bridge between alternant and non-alternant hydrocarbons. This topic might serve as a useful addition to Hückel theory courses targeted at senior undergraduate students.

  3. What future for ribavirin?

    Science.gov (United States)

    Shiffman, Mitchell L

    2009-01-01

    The optimal therapy for patients with the chronic hepatitis C virus (HCV) is a combination of peginterferon and ribavirin. Treating HCV without ribavirin or prematurely discontinuing, frequently missing doses of ribavirin is associated with a significant decline in virological response, and an increase in both breakthrough viraemia and relapse. The major limitation of ribavirin is adverse events, the most common of which is haemolytic anaemia. Haemolysis is modest when ribavirin is utilized as monotherapy, but is significantly increased when combined with interferon or peginterferon. For these reasons, attempts to replace ribavirin with a less toxic alternative have been advanced. Unfortunately, even when ribavirin is replaced by a potent protease inhibitor, relapse is significantly increased and SVR is reduced. The future of HCV treatment is to combine peginterferon and ribavirin with several protease and/or polymerase inhibitors. Whether this strategy will allow ribavirin to be removed from the treatment paradigm remains to be proven. However, based on the results of clinical trials conducted to date, it is much more likely that peginterferon, not ribavirin, could be expendable.

  4. Operational assessment of intermodality future in Belgium: Best-case scenario

    OpenAIRE

    Tawfik, Christine Maher Fouad; Limbourg, Sabine

    2017-01-01

    From the perspective of stimulating intermodal transport as an ecological and economically promising freight transport scheme in the EU, this paper is devoted to assess its future position with respect to crucial and plausible operational factors that were selected a priori. The study is conducted in the context of a best-case scenario development, within a rational and optimal decision making framework. We address this goal by designing a realistic medium-term network design and pricing mode...

  5. Renewable Electricity Futures Study. Executive Summary

    Energy Technology Data Exchange (ETDEWEB)

    Mai, T.; Sandor, D.; Wiser, R.; Schneider, T.

    2012-12-01

    The Renewable Electricity Futures (RE Futures) Study investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. The analysis focused on the sufficiency of the geographically diverse U.S. renewable resources to meet electricity demand over future decades, the hourly operational characteristics of the U.S. grid with high levels of variable wind and solar generation, and the potential implications of deploying high levels of renewables in the future. RE Futures focused on technical aspects of high penetration of renewable electricity; it did not focus on how to achieve such a future through policy or other measures. Given the inherent uncertainties involved with analyzing alternative long-term energy futures as well as the multiple pathways that might be taken to achieve higher levels of renewable electricity supply, RE Futures explored a range of scenarios to investigate and compare the impacts of renewable electricity penetration levels (30%-90%), future technology performance improvements, potential constraints to renewable electricity development, and future electricity demand growth assumptions. RE Futures was led by the National Renewable Energy Laboratory (NREL) and the Massachusetts Institute of Technology (MIT).

  6. Insertion of O-H Bond of Rh(Ⅱ)-methylene Carbene into Alcohols: A Stepwise Mechanism More Plausible than a Concerted Mechanism

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The mechanisms of insertion of O-H bond of Rh( Ⅱ ) -methylene carbene into methanol and ethanol were studied by using B3LYP functional both in gas phase and in CH2Cl2. The formation of free alcoholic oxonium ylides is found to be impossible. Alcoholic oxonium ylide are formed as the intermediates before both the stepwise and the concerted transition states of insertion of O-H bond of Rh( Ⅱ ) -methylene carbene into methanol and ethanol. With regard to the mechanisms of insertion of O-H of Rh( Ⅱ ) -methylene carbene into alcohols, analysis of the energy barriers of the two mechanisms indicate that the stepwise mechanism is more plausible than the concerted mechanism.

  7. Relatively Selective Production of the Simplest Criegee Intermediate in a CH4/O2 Electric Discharge: Kinetic Analysis of a Plausible Mechanism.

    Science.gov (United States)

    Nguyen, Thanh Lam; McCarthy, Michael C; Stanton, John F

    2015-07-16

    High -accuracy coupled cluster methods in combination with microcanonical semiclassical transition state theory are used to investigate a plausible formation mechanism of the simplest Criegee intermediate in a CH4/O2 discharge experiment. Our results suggest that the Criegee intermediate is produced in a three-step process: (i) production of methyl radical by cleavage of a C-H bond of CH4; (ii) association of methyl radical with molecular oxygen to form a vibrationally excited methyl peroxy, which is in a rapid microequilibrium with the reactants; and finally, (iii) H-abstraction of CH3OO by O2, which results in the formation of cool CH2OO, which has insufficient internal energy to rearrange to dioxirane.

  8. Is the Framework of Cohn's 'Tritope Model' for How T Cell Receptors Recognize Peptide/Self-MHC Complexes and Allo-MHC Plausible?

    Science.gov (United States)

    Bretscher, Peter A

    2016-05-01

    Cohn has developed the tritope model to describe how distinct domains of the T cell receptor (TcR) recognize peptide/self-MHC complexes and allo-MHC. He has over the years employed this model as a framework for considering how the TcR might mediate various signals [1-5]. In a recent publication [5], Cohn employs the Tritope Model to propose a detailed mechanism for the T cell receptor's involvement in positive thymic selection [5]. During a review of this proposal, I became uneasy over the plausibility of the underlying framework of the Tritope Model. I outline here the evolutionary considerations making me question this framework. I also suggest that the proposed framework underlying the Tritope Model makes strong predictions whose validity can most probably be assessed by considering observations reported in the literature.

  9. An Italian population-based case-control study on the association between farming and cancer: Are pesticides a plausible risk factor?

    Science.gov (United States)

    Salerno, Christian; Carcagnì, Antonella; Sacco, Sara; Palin, Lucio Antonio; Vanhaecht, Kris; Panella, Massimiliano; Guido, Davide

    2016-05-01

    This population-based case-control study investigated the association between farming (a proxy for pesticide exposure) and cancer in the Vercelli suburban area (northwest Italy). The residents, aged 25 to 79 years, in the above-mentioned area during the period 2002-2009 were considered. Cases were all the first hospital admissions for cancer. Controls were all the subjects not included in the cases and not excluded from the study. Cases and controls were classified according to whether they occupationally resulted farmers or nonfarmers during the period 1965-2009. Cancer odds ratios (ORs) between farmers and nonfarmers were calculated with generalized linear mixed models adjusted by gender and age. Farmers showed higher odds for all cancers (OR=1.459; p plausible association between pesticide exposure and cancer occurrence.

  10. Changes in the Distribution of Lesser Adjutant Storks (Leptoptilos javanicus in South and Southeast Asia: A Plausible Evidence of Global Climate and Land-use Change Effect

    Directory of Open Access Journals (Sweden)

    Kapil K. Khadka

    2014-01-01

    Full Text Available Species distribution Models (SDMs illustrate the relation between species and environmental variables. In an attempt to model the historical and current distribution of Lesser Adjutant Stork (Leptoptilos javanicus and gain qualitative insight into range shift, maxEnt modeling approach was applied. The model was projected into maps to illustrate the variation in spatial distribution of the species in South and Southeast Asia over time. A distributional shift was observed towards the north accompanied by range contraction to the south and expansion to the north. Besides, annual precipitation and temperature of the coldest period of a year appeared to be the major climatic determinants of species distribution. It provides plausible evidence of global climate and land-use change effect on the bird’s distribution and suggests avenues for further research.

  11. Medial Temporal Lobe Contributions to Episodic Future Thinking: Scene Construction or Future Projection?

    Science.gov (United States)

    Palombo, D J; Hayes, S M; Peterson, K M; Keane, M M; Verfaellie, M

    2016-12-01

    Previous research has shown that the medial temporal lobes (MTL) are more strongly engaged when individuals think about the future than about the present, leading to the suggestion that future projection drives MTL engagement. However, future thinking tasks often involve scene processing, leaving open the alternative possibility that scene-construction demands, rather than future projection, are responsible for the MTL differences observed in prior work. This study explores this alternative account. Using functional magnetic resonance imaging, we directly contrasted MTL activity in 1) high scene-construction and low scene-construction imagination conditions matched in future thinking demands and 2) future-oriented and present-oriented imagination conditions matched in scene-construction demands. Consistent with the alternative account, the MTL was more active for the high versus low scene-construction condition. By contrast, MTL differences were not observed when comparing the future versus present conditions. Moreover, the magnitude of MTL activation was associated with the extent to which participants imagined a scene but was not associated with the extent to which participants thought about the future. These findings help disambiguate which component processes of imagination specifically involve the MTL. Published by Oxford University Press 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.

  12. Incompatible Ages for Clearwing Butterflies Based on Alternative Secondary Calibrations.

    Science.gov (United States)

    Garzón-Orduña, Ivonne J; Silva-Brandão, Karina L; Willmott, Keith R; Freitas, André V L; Brower, Andrew V Z

    2015-09-01

    The recent publication of a time-tree for the plant family Solanaceae (nightshades) provides the opportunity to use independent calibrations to test divergence times previously inferred for the diverse Neotropical butterfly tribe Ithomiini. Ithomiini includes clades that are obligate herbivores of Solanaceae, with some genera feeding on only one genus. We used 8 calibrations extracted from the plant tree in a new relaxed molecular-clock analysis to produce an alternative temporal framework for the diversification of ithomiines. We compared the resulting age estimates to: (i) a time-tree obtained using 7 secondary calibrations from the Nymphalidae tree of Wahlberg et al. (2009), and (ii) Wahlberg et al.'s (2009) original age estimates for the same clades. We found that Bayesian clock estimates were rather sensitive to a variety of analytical parameters, including taxon sampling. Regardless of this sensitivity however, ithomiine divergence times calibrated with the ages of nightshades were always on average half the age of previous estimates. Younger dates for ithomiine clades appear to fit better with factors long suggested to have promoted diversification of the group such as the uplifting of the Andes, in the case of montane genera. Alternatively, if ithomiines are as old as previous estimates suggest, the recent ages inferred for the diversification of Solanaceae seem likely to be seriously underestimated. Our study exemplifies the difficulty of testing hypotheses of divergence times and of choosing between alternative dating scenarios, and shows that age estimates based on seemingly plausible calibrations may be grossly incongruent.

  13. FutureCoast: "Listen to your futures"

    Science.gov (United States)

    Pfirman, S. L.; Eklund, K.; Thacher, S.; Orlove, B. S.; Diane Stovall-Soto, G.; Brunacini, J.; Hernandez, T.

    2014-12-01

    Two science-arts approaches are emerging as effective means to convey "futurethinking" to learners: systems gaming and experiential futures. FutureCoast exemplifies the latter: by engaging participants with voicemails supposedly leaking from the cloud of possible futures, the storymaking game frames the complexities of climate science in relatable contexts. Because participants make the voicemails themselves, FutureCoast opens up creative ways for people to think about possibly climate-changed futures and personal ways to talk about them. FutureCoast is a project of the PoLAR Partnership with a target audience of informal adult learners primarily reached via mobile devices and online platforms. Scientists increasingly use scenarios and storylines as ways to explore the implications of environmental change and societal choices. Stories help people make connections across experiences and disciplines and link large-scale events to personal consequences. By making the future seem real today, FutureCoast's framework helps people visualize and plan for future climate changes. The voicemails contributed to FutureCoast are spread through the game's intended timeframe (2020 through 2065). Based on initial content analysis of voicemail text, common themes include ecosystems and landscapes, weather, technology, societal issues, governance and policy. Other issues somewhat less frequently discussed include security, food, industry and business, health, energy, infrastructure, water, economy, and migration. Further voicemail analysis is examining: temporal dimensions (salient time frames, short vs. long term issues, intergenerational, etc.), content (adaptation vs. mitigation, challenges vs. opportunities, etc.), and emotion (hopeful, resigned, etc. and overall emotional context). FutureCoast also engaged audiences through facilitated in-person experiences, geocaching events, and social media (Tumblr, Twitter, Facebook, YouTube). Analysis of the project suggests story

  14. [Alternatives to animal testing].

    Science.gov (United States)

    Fabre, Isabelle

    2009-11-01

    The use of alternative methods to animal testing are an integral part of the 3Rs concept (refine, reduce, replace) defined by Russel & Burch in 1959. These approaches include in silico methods (databases and computer models), in vitro physicochemical analysis, biological methods using bacteria or isolated cells, reconstructed enzyme systems, and reconstructed tissues. Emerging "omic" methods used in integrated approaches further help to reduce animal use, while stem cells offer promising approaches to toxicologic and pathophysiologic studies, along with organotypic cultures and bio-artificial organs. Only a few alternative methods can so far be used in stand-alone tests as substitutes for animal testing. The best way to use these methods is to integrate them in tiered testing strategies (ITS), in which animals are only used as a last resort.

  15. Alternative nanostructures for thermophones

    Science.gov (United States)

    Mayo, Nathanael; Aliev, Ali; Baughman, Ray

    2015-03-01

    There is a large promise for thermophones in high power sonar arrays, flexible loudspeakers, and noise cancellation devices. So far, freestanding aerogel-like carbon nanotube sheets demonstrate the best performance as a thermoacoustic heat source. However, the limited accessibility of large size freestanding carbon nanotube sheets and other even more exotic materials published recently, hampers the field. We present here new alternative materials for a thermoacoustic heat source with high energy conversion efficiency, additional functionalities, environmentally friendly and cost effective production technologies. We discuss the thermoacoustic performance of alternative nanoscale materials and compare their spectral and power dependencies of sound pressure in air. The study presented here focuses on engineering thermal gradients in the vicinity of nanostructures and subsequent heat dissipation processes from the interior of encapsulated thermoacoustic projectors. Applications of thermoacoustic projectors for high power SONAR arrays, sound cancellation, and optimal thermal design, regarding enhanced energy conversion efficiency, are discussed.

  16. Adaptive Alternating Minimization Algorithms

    CERN Document Server

    Niesen, Urs; Wornell, Gregory

    2007-01-01

    The classical alternating minimization (or projection) algorithm has been successful in the context of solving optimization problems over two variables or equivalently of finding a point in the intersection of two sets. The iterative nature and simplicity of the algorithm has led to its application to many areas such as signal processing, information theory, control, and finance. A general set of sufficient conditions for the convergence and correctness of the algorithm is quite well-known when the underlying problem parameters are fixed. In many practical situations, however, the underlying problem parameters are changing over time, and the use of an adaptive algorithm is more appropriate. In this paper, we study such an adaptive version of the alternating minimization algorithm. As a main result of this paper, we provide a general set of sufficient conditions for the convergence and correctness of the adaptive algorithm. Perhaps surprisingly, these conditions seem to be the minimal ones one would expect in ...

  17. Metamaterials critique and alternatives

    CERN Document Server

    Munk, Ben A

    2009-01-01

    A Convincing and Controversial Alternative Explanation of Metamaterials with a Negative Index of Refraction In a book that will generate both support and controversy, one of the world's foremost authorities on periodic structures addresses several of the current fashions in antenna design-most specifically, the popular subject of double negative metamaterials. Professor Munk provides a comprehensive theoretical electromagnetic investigation of the issues and concludes that many of the phenomena claimed by researchers may be impossible. While denying the existence of negative refractio

  18. Outlook for alternative transportation fuels

    Energy Technology Data Exchange (ETDEWEB)

    Gushee, D.E. [Univ. of Illinois, Chicago, IL (United States)

    1996-12-31

    This presentation provides a brief review of regulatory issues and Federal programs regarding alternative fuel use in automobiles. A number of U.S. DOE initiatives and studies aimed at increasing alternative fuels are outlined, and tax incentives in effect at the state and Federal levels are discussed. Data on alternative fuel consumption and alternative fuel vehicle use are also presented. Despite mandates, tax incentives, and programs, it is concluded alternative fuels will have minimal market penetration. 7 refs., 5 tabs.

  19. Alternative Fuels: Research Progress

    Directory of Open Access Journals (Sweden)

    Maher A.R. Sadiq Al-Baghdadi

    2013-01-01

    Full Text Available Chapter 1: Pollutant Emissions and Combustion Characteristics of Biofuels and Biofuel/Diesel Blends in Laminar and Turbulent Gas Jet Flames. R. N. Parthasarathy, S. R. Gollahalli Chapter 2: Sustainable Routes for The Production of Oxygenated High-Energy Density Biofuels from Lignocellulosic Biomass. Juan A. Melero, Jose Iglesias, Gabriel Morales, Marta Paniagua Chapter 3: Optical Investigations of Alternative-Fuel Combustion in an HSDI Diesel Engine. T. Huelser, M. Jakob, G. Gruenefeld, P. Adomeit, S. Pischinger Chapter 4: An Insight into Biodiesel Physico-Chemical Properties and Exhaust Emissions Based on Statistical Elaboration of Experimental Data. Evangelos G. Giakoumis Chapter 5: Biodiesel: A Promising Alternative Energy Resource. A.E. Atabani Chapter 6: Alternative Fuels for Internal Combustion Engines: An Overview of the Current Research. Ahmed A. Taha, Tarek M. Abdel-Salam, Madhu Vellakal Chapter 7: Investigating the Hydrogen-Natural Gas Blends as a Fuel in Internal Combustion Engine. ?lker YILMAZ Chapter 8: Conversion of Bus Diesel Engine into LPG Gaseous Engine; Method and Experiments Validation. M. A. Jemni , G. Kantchev , Z. Driss , R. Saaidia , M. S. Abid Chapter 9: Predicting the Combustion Performance of Different Vegetable Oils-Derived Biodiesel Fuels. Qing Shu, ChangLin Yu Chapter 10: Production of Gasoline, Naphtha, Kerosene, Diesel, and Fuel Oil Range Fuels from Polypropylene and Polystyrene Waste Plastics Mixture by Two-Stage Catalytic Degradation using ZnO. Moinuddin Sarker, Mohammad Mamunor Rashid

  20. Identifying Second Language Errors: How Plausible are Plausible Reconstructions?

    Science.gov (United States)

    Hamid, Obaidul

    2007-01-01

    The research reported in the study was undertaken to measure English language teachers' ability to interpret second language learners' intended meanings in idiosyncratic utterances in written English. In doing so, it also aimed at verifying Corder's (1981) speculation that language teachers can correctly guess the intended meanings of learners in…

  1. Renewable Electricity Futures Study. Volume 1. Exploration of High-Penetration Renewable Electricity Futures

    Energy Technology Data Exchange (ETDEWEB)

    Hand, M. M. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Baldwin, S. [U.S. Dept. of Energy, Washington, DC (United States); DeMeo, E. [Renewable Energy Consulting, Chicago, IL (United States); Reilly, J. M. [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Mai, T. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Arent, D. [Joint Inst. for Strategic Energy Analysis, Boulder, CO (United States); Porro, G. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Meshek, M. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Sandor, D. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2012-06-15

    The Renewable Electricity Futures (RE Futures) Study investigated the challenges and impacts of achieving very high renewable electricity generation levels in the contiguous United States by 2050. The analysis focused on the sufficiency of the geographically diverse U.S. renewable resources to meet electricity demand over future decades, the hourly operational characteristics of the U.S. grid with high levels of variable wind and solar generation, and the potential implications of deploying high levels of renewables in the future. RE Futures focused on technical aspects of high penetration of renewable electricity; it did not focus on how to achieve such a future through policy or other measures. Given the inherent uncertainties involved with analyzing alternative long-term energy futures as well as the multiple pathways that might be taken to achieve higher levels of renewable electricity supply, RE Futures explored a range of scenarios to investigate and compare the impacts of renewable electricity penetration levels (30%–90%), future technology performance improvements, potential constraints to renewable electricity development, and future electricity demand growth assumptions. RE Futures was led by the National Renewable Energy Laboratory (NREL) and the Massachusetts Institute of Technology (MIT). Learn more at the RE Futures website. http://www.nrel.gov/analysis/re_futures/

  2. Alternative time representation in dopamine models.

    Science.gov (United States)

    Rivest, François; Kalaska, John F; Bengio, Yoshua

    2010-02-01

    Dopaminergic neuron activity has been modeled during learning and appetitive behavior, most commonly using the temporal-difference (TD) algorithm. However, a proper representation of elapsed time and of the exact task is usually required for the model to work. Most models use timing elements such as delay-line representations of time that are not biologically realistic for intervals in the range of seconds. The interval-timing literature provides several alternatives. One of them is that timing could emerge from general network dynamics, instead of coming from a dedicated circuit. Here, we present a general rate-based learning model based on long short-term memory (LSTM) networks that learns a time representation when needed. Using a naïve network learning its environment in conjunction with TD, we reproduce dopamine activity in appetitive trace conditioning with a constant CS-US interval, including probe trials with unexpected delays. The proposed model learns a representation of the environment dynamics in an adaptive biologically plausible framework, without recourse to delay lines or other special-purpose circuits. Instead, the model predicts that the task-dependent representation of time is learned by experience, is encoded in ramp-like changes in single-neuron activity distributed across small neural networks, and reflects a temporal integration mechanism resulting from the inherent dynamics of recurrent loops within the network. The model also reproduces the known finding that trace conditioning is more difficult than delay conditioning and that the learned representation of the task can be highly dependent on the types of trials experienced during training. Finally, it suggests that the phasic dopaminergic signal could facilitate learning in the cortex.

  3. Sustainability - What are the Odds? Guessing the Future of our Environment, Economy, and Society

    Science.gov (United States)

    This article examines the concept of sustainability from a global perspective, describing how alternative futures might develop in the environmental, economic, and social dimensions. The alternatives to sustainability appear to be (a) a catastrophic failure of life support, econo...

  4. Alternating layers of plutonium and lead or indium as surrogate for plutonium

    Energy Technology Data Exchange (ETDEWEB)

    Rudin, Sven P, E-mail: srudin@lanl.gov [Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545 (United States)

    2010-03-15

    Elemental plutonium (Pu) assumes more crystal structures than other elements, plausibly due to bonding f electrons becoming non-bonding. Complex geometries hamper understanding of the transition in Pu, but calculations predict this transition in a system with simpler geometry: alternating layers either of plutonium and lead or of plutonium and indium. Here the transition occurs via a pairing-up of atoms within Pu layers. Calculations stepping through this pairing-up reveal valuable details of the transition, for example that the transition from bonding to non-bonding proceeds smoothly.

  5. Alternating layers of plutonium and lead or indium as surrogate for plutonium

    Energy Technology Data Exchange (ETDEWEB)

    Rudin, Sven Peter [Los Alamos National Laboratory

    2009-01-01

    Elemental plutonium (Pu) assumes more crystal structures than other elements, plausibly due to bonding f electrons becoming non-bonding. Complex geometries hamper understanding of the transition in Pu, but calculations predict this transition in a system with simpler geometry: alternating layers either of plutonium and lead or of plutonium and indium. Here the transition occurs via a pairing-up of atoms within Pu layers. Calculations stepping through this pairing-up reveal valuable details of the transition, for example that the transition from bonding to non-bonding proceeds smoothly.

  6. 17 CFR 242.302 - Recordkeeping requirements for alternative trading systems.

    Science.gov (United States)

    2010-04-01

    ... alternative trading systems. 242.302 Section 242.302 Commodity and Securities Exchanges SECURITIES AND... SECURITY FUTURES Regulation Ats-Alternative Trading Systems § 242.302 Recordkeeping requirements for alternative trading systems. To comply with the condition set forth in paragraph (b)(8) of § 242.301,...

  7. 17 CFR 242.303 - Record preservation requirements for alternative trading systems.

    Science.gov (United States)

    2010-04-01

    ... requirements for alternative trading systems. 242.303 Section 242.303 Commodity and Securities Exchanges... REQUIREMENTS FOR SECURITY FUTURES Regulation Ats-Alternative Trading Systems § 242.303 Record preservation requirements for alternative trading systems. (a) To comply with the condition set forth in paragraph (b)(9)...

  8. Inventing the Future: Options and Strategies for Educators.

    Science.gov (United States)

    Burdin, Joel L.; And Others

    1984-01-01

    An overview of alternative futurism and implications and applications for the elementary and secondary grades are provided in this article. The teacher's role is explored in a discussion of development of educational personnel. (DF)

  9. Plausible Reasoning in Tactical Planning.

    Science.gov (United States)

    1987-04-01

    Frames in a Person’s Memory i • flower type/of =(plant) types =Irose, daffodil, peony, bougainvillea ... parts =Ipetals, stem ..-I colors =Ipink...J World South AmericF r ESubtropical Surrey Flowers Daffodils Bougainvillea Peonies Roses Yellow RosesFa Figure 4. Part Hierarchy for England and...England) = Iyellow roses...I (7) SIm flower-type(England)= 1peonies... I (8) DIS flower-type(England)6 bougainvillea ... * *18 that they think are most

  10. Plausibility Arguments and Universal Gravitation

    Science.gov (United States)

    Cunha, Ricardo F. F.; Tort, A. C.

    2017-01-01

    Newton's law of universal gravitation underpins our understanding of the dynamics of the Solar System and of a good portion of the observable universe. Generally, in the classroom or in textbooks, the law is presented initially in a qualitative way and at some point during the exposition its mathematical formulation is written on the blackboard…

  11. Plausible Mechanisms of Cadmium Carcinogenesis

    Science.gov (United States)

    Cadmium is a transition metal and an ubiquitous environmental and industrial pollutant. Laboratory animal studies and epidemiological studies have shown that exposure to cadmium is associated with various organ toxicities and carcinogenic effects. Several national and internation...

  12. Polyandry and alternative mating tactics.

    Science.gov (United States)

    Neff, Bryan D; Svensson, Erik I

    2013-03-05

    Many species in the animal kingdom are characterized by alternative mating tactics (AMTs) within a sex. In males, such tactics include mate guarding versus sneaking behaviours, or territorial versus female mimicry. Although AMTs can occur in either sex, they have been most commonly described in males. This sex bias may, in part, reflect the increased opportunity for sexual selection that typically exists in males, which can result in a higher probability that AMTs evolve in that sex. Consequently, females and polyandry can play a pivotal role in governing the reproductive success associated with male AMTs and in the evolutionary dynamics of the tactics. In this review, we discuss polyandry and the evolution of AMTs. First, we define AMTs and review game theoretical and quantitative genetic approaches used to model their evolution. Second, we review several examples of AMTs, highlighting the roles that genes and environment play in phenotype expression and development of the tactics, as well as empirical approaches to differentiating among the mechanisms. Third, ecological and genetic constraints to the evolution of AMTs are discussed. Fourth, we speculate on why female AMTs are less reported on in the literature than male tactics. Fifth, we examine the effects of AMTs on breeding outcomes and female fitness, and as a source, and possibly also a consequence, of sexual conflict. We conclude by suggesting a new model for the evolution of AMTs that incorporates both environmental and genetic effects, and discuss some future avenues of research.

  13. Alternative to Nitric Acid Passivation

    Science.gov (United States)

    Kessel, Kurt R.

    2015-01-01

    The Ground Systems Development and Operations (GSDO) Program at NASA John F. Kennedy Space Center (KSC), Florida, has the primary objective of modernizing and transforming the launch and range complex at KSC to benefit current and future NASA programs along with other emerging users. Described as the launch support and infrastructure modernization program in the NASA Authorization Act of 2010, the GSDO Program will develop and implement shared infrastructure and process improvements to provide more flexible, affordable, and responsive capabilities to a multi-user community. In support of NASA and the GSDO Program, the objective of this project is to qualify citric acid as an environmentally-preferable alternative to nitric acid for passivation of stainless steel alloys. This project is a direct follow-on to United Space Alliance (USA) work at KSC to optimize the parameters for the use of citric acid and verify effectiveness. This project will build off of the USA study to further evaluate citric acids effectiveness and suitability for corrosion protection of a number of stainless steels alloys used by NASA, the Department of Defense (DoD), and the European Space Agency (ESA).

  14. Alternate fuels; Combustibles alternos

    Energy Technology Data Exchange (ETDEWEB)

    Romero Paredes R, Hernando; Ambriz G, Juan Jose [Universidad Autonoma Metropolitana. Iztapalapa (Mexico)

    2003-07-01

    In the definition and description of alternate fuels we must center ourselves in those technological alternatives that allow to obtain compounds that differ from the traditional ones, in their forms to be obtained. In this article it is tried to give an overview of alternate fuels to the conventional derivatives of petroleum and that allow to have a clear idea on the tendencies of modern investigation and the technological developments that can be implemented in the short term. It is not pretended to include all the tendencies and developments of the present world, but those that can hit in a relatively short term, in accordance with agreed with the average life of conventional fuels. Nevertheless, most of the conversion principles are applicable to the spectrum of carbonaceous or cellulosic materials which are in nature, are cultivated or wastes of organic origin. Thus one will approach them in a successive way, the physical, chemical and biological conversions that can take place in a production process of an alternate fuel or the same direct use of the fuel such as burning the sweepings derived from the forests. [Spanish] En la definicion y descripcion de combustibles alternos nos debemos centrar en aquellas alternativas tecnologicas que permitan obtener compuestos que difieren de los tradicionales, al menos en sus formas de ser obtenidos. En este articulo se pretende dar un panorama de los combustibles alternos a los convencionales derivados del petroleo y que permita tener una idea clara sobre las tendencias de la investigacion moderna y los desarrollos tecnologicos que puedan ser implementados en el corto plazo. No se pretende abarcar todas las tendencias y desarrollos del mundo actual, sino aquellas que pueden impactar en un plazo relativamente corto, acordes con la vida media de los combustibles convencionales. Sin embargo, la mayor parte de los principios de conversion son aplicables al espectro de materiales carbonaceos o celulosicos los cuales se

  15. Lipase supplementation therapy: standards, alternatives, and perspectives.

    Science.gov (United States)

    Layer, Peter; Keller, Jutta

    2003-01-01

    Treatment of steatorrhea by lipase supplementation therapy has become more successful in the last decade due to better understanding of the physiology and pathophysiology of the digestive process. Porcine lipase has been the therapeutic standard for several decades and will continue to be the treatment of choice in pancreatic exocrine insufficiency. Modern therapeutic concepts recommend administration of 25,000-40,000 units of porcine lipase per meal using pH-sensitive pancreatin microspheres. In case of treatment failure, the dose should be increased, compliance should be checked, and other reasons for malabsorption should be excluded. Still, in most patients, lipid digestion cannot be completely normalized by current standard therapy, and future developments are needed for optimizing treatment. In this article, pathophysiologic characteristics of pancreatic exocrine insufficiency, prerequisites for use of alternative lipase sources as well as currently available lipases of nonporcine origin, and new developments are discussed. Current literature suggests that bovine lipase products present a theoretical alternative but play no major role in the western world. Fungal lipase has inferior properties compared with conventional products. Bacterial lipase products show promising potential and offer future therapeutic alternatives. Moreover, human pancreatic lipase gene transfer and application of bioengineered human gastric lipase appear on the horizon.

  16. Future glaciation in Fennoscandia

    Energy Technology Data Exchange (ETDEWEB)

    Forsstroem, L. [Oulu Univ. (Finland). Dept. of Geosciences

    1999-09-01

    Cyclic growing and melting of great ice sheets in the Northern Hemisphere is typical for the Quaternary Period, and it is likely that this cycle will continue in the future. This report discusses the principal processes predicted to occur during the future glaciation which are likely to be of importance for a nuclear waste repository. It is a revised version of a synthesis of the results of two state-of-the art reports, working meetings and a seminar. Based on present knowledge, two alternative trends (A and B) can be presented for fluctuations in climate in Fennoscandia. According to forecast A the climate will gradually become colder, permitting the growth of glaciers in the mountainous areas of Norway and Sweden after 5000 years. After a minor warmer period, a greater ice advance will cover a large part of Finland around 20 000 years from now. After a new minor interstade, the ice will advance again, so that c. 60 000 years from now the Stockholm-Helsinki region will be covered by thick ice. The ice sheet will melt partially at 70 000 years AP, but then it will grow to its maximum around 100 000 years AP and cover the whole Baltic basin. Almost complete melting of the ice sheet will take place during the next interglaciation c. 120 coo years AP. According to forecast B the growth of the ice sheet will not begin for another 50 000 years, and Finland will be covered by ice about 60 000 years from now. After a minor melting, the ice sheet will enlarge and cover almost the whole Baltic basin 100 000 years from now. During the following ice minimum, at 120 000 years AP, the ice sheet will still cover northern Finland. At 150 000 years it will cover the whole Baltic basin, but then it will melt almost completely by 165 000 years from now, during the following interglaciation. In both forecasts the main changes caused by the ice sheet will be downwarping/uplift of the crust and changes in sea level. In addition, changes in the groundwater head and flux are foreseen

  17. Multiple feedbacks and the prevalence of alternate stable states on coral reefs

    Science.gov (United States)

    van de Leemput, Ingrid A.; Hughes, Terry P.; van Nes, Egbert H.; Scheffer, Marten

    2016-09-01

    The prevalence of alternate stable states on coral reefs has been disputed, although there is universal agreement that many reefs have experienced substantial losses of coral cover. Alternate stable states require a strong positive feedback that causes self-reinforcing runaway change when a threshold is passed. Here we use a simple model of the dynamics of corals, macroalgae and herbivores to illustrate that even weak positive feedbacks that individually cannot lead to alternate stable states can nonetheless do so if they act in concert and reinforce each other. Since the strength of feedbacks varies over time and space, our results imply that we should not reject or accept the general hypothesis that alternate stable states occur in coral reefs. Instead, it is plausible that shifts between alternate stable states can occur sporadically, or on some reefs but not others depending on local conditions. Therefore, we should aim at a better mechanistic understanding of when and why alternate stable states may occur. Our modelling results point to an urgent need to recognize, quantify, and understand feedbacks, and to reorient management interventions to focus more on the mechanisms that cause abrupt transitions between alternate states.

  18. Positioning Food Cultures: 'Alternative' Food as Distinctive Consumer Practice.

    Science.gov (United States)

    Paddock, Jessica

    2016-12-01

    Many sociological studies to date have explored the role of food in marking distinctions between groups. Less well understood is how 'alternative' means of food consumption become figured in such relations. Drawing on accounts of food practice derived from 20 in-depth interviews and a two-year period of participant observation, this article considers the role of class culture in the practice of alternative food consumption. As participants speak their position, expressions of class arise through discussions of food practice. Having explored how food plays a part in marking boundaries of distinction between foods 'for us' and 'for them', we are reminded that in reproducing certain ideas about proper eating, we confine our imagining of alternative food futures to a limited politics of the possible. The article highlights implications for future development of equitable alternatives to conventional foodways.

  19. Alternate Location Method of a Robot Team in Unknown Environment

    Institute of Scientific and Technical Information of China (English)

    WANG Jian-zhong; LIU Jing-jing

    2008-01-01

    The alternate location method of a robot team is proposed. Three of the robots are kept still as beacon robots, not always the same ones, while the others are regarded as mobile robots. The mobile robots alternatively measure the distance between one of them and three beacon robots with ultrasonic measurement module. The distance data are combined with its dead-reckoning information using iterated extended Kalman filter(IEKF) to realize the optimal estimate of its position. According to the condition the future beacon robots positions should be desired ones, the target function and the nonlinear constrain equations are set up which are used by nonlinear optimization algorithm to estimate the position of the future beacon robots. By alternately changing the robots roles as active beacon, the alternate location in unknown environment can be realized. Process and result of the simulation test are given and the position estimation error is within±10mm, which proves the validity of this method.

  20. Tuberculosis of the future

    Directory of Open Access Journals (Sweden)

    Tjandra Y. Aditama

    2002-09-01

    program could be one of the alternative. (Med J Indones 2002; 11: 190-4 Keywords: tuberculosis, future and recent advances

  1. Regional climate impacts of a possible future grand solar minimum.

    Science.gov (United States)

    Ineson, Sarah; Maycock, Amanda C; Gray, Lesley J; Scaife, Adam A; Dunstone, Nick J; Harder, Jerald W; Knight, Jeff R; Lockwood, Mike; Manners, James C; Wood, Richard A

    2015-06-23

    Any reduction in global mean near-surface temperature due to a future decline in solar activity is likely to be a small fraction of projected anthropogenic warming. However, variability in ultraviolet solar irradiance is linked to modulation of the Arctic and North Atlantic Oscillations, suggesting the potential for larger regional surface climate effects. Here, we explore possible impacts through two experiments designed to bracket uncertainty in ultraviolet irradiance in a scenario in which future solar activity decreases to Maunder Minimum-like conditions by 2050. Both experiments show regional structure in the wintertime response, resembling the North Atlantic Oscillation, with enhanced relative cooling over northern Eurasia and the eastern United States. For a high-end decline in solar ultraviolet irradiance, the impact on winter northern European surface temperatures over the late twenty-first century could be a significant fraction of the difference in climate change between plausible AR5 scenarios of greenhouse gas concentrations.

  2. Alternate Gauge Electroweak Model

    CERN Document Server

    Dalton, Bill

    2010-01-01

    We describe an alternate gauge electroweak model that permits neutrinos with mass, and at the same time explains why right-handed neutrinos do not appear in weak interactions. This is a local gauge theory involving a space [V ] of three scalar functions. The standard Lagrangian density for the Yang-Mills field part and Higgs doublet remain invariant. A ma jor change is made in the transformation and corresponding Lagrangian density parts involving the right-handed leptons. A picture involving two types of right-handed leptons emerges. A dichotomy of matter on the [V ] space corresponds to coupled and uncoupled right-handed Leptons. Here, we describe a covariant dipole-mode solution in which the neutral bosons A{\\mu} and Z{\\mu} produce precessions on [V ]. The W {\\pm} {\\mu} bosons provide nutations on [V ], and consequently, provide transitions between the coupled and uncoupled regions. To elucidate the [V ] space matter dichotomy, and to generate the boson masses, we also provide an alternate potential Lagran...

  3. Alternative Therapies for PKU

    Directory of Open Access Journals (Sweden)

    Norma Spécola MD

    2017-01-01

    Full Text Available The phenylalanine (PHE-restricted diet has improved in quality and diversity over time and has proven to be effective in all patients. Nevertheless, this treatment imposes a heavy social and economic burden to patient and family and impacts quality of life. Sustained adherence to PHE restriction is difficult to maintain. Moreover, even patients with phenylketonuria (PKU with normal intelligence quotient (IQ have lower IQ than matched individuals without PKU and can have deficits in multiple other aspects of neuropsychological function, including cognitive and executive function, working memory. They can also have behavior problems, depression, and low self-esteem. In recent years, alternative treatments for PKU have been developed and their use has been indicated for some patients who are candidates for options besides traditional treatment. Sapropterindihydrochloride, large neutral amino acids, and glycomacropeptide are alternative treatment options in use for selected patients. The aim of this article is to review the current knowledge of these new approaches to PKU treatment.

  4. Alternative Medicine and Your Child

    Science.gov (United States)

    ... 1- to 2-Year-Old Complementary and Alternative Medicine KidsHealth > For Parents > Complementary and Alternative Medicine A ... works. previous continue How CAM Differs From Traditional Medicine CAM is frequently distinguished by its holistic methods, ...

  5. Dimethyl ether (DME) as an alternative fuel

    Science.gov (United States)

    Semelsberger, Troy A.; Borup, Rodney L.; Greene, Howard L.

    With ever growing concerns on environmental pollution, energy security, and future oil supplies, the global community is seeking non-petroleum based alternative fuels, along with more advanced energy technologies (e.g., fuel cells) to increase the efficiency of energy use. The most promising alternative fuel will be the fuel that has the greatest impact on society. The major impact areas include well-to-wheel greenhouse gas emissions, non-petroleum feed stocks, well-to-wheel efficiencies, fuel versatility, infrastructure, availability, economics, and safety. Compared to some of the other leading alternative fuel candidates (i.e., methane, methanol, ethanol, and Fischer-Tropsch fuels), dimethyl ether appears to have the largest potential impact on society, and should be considered as the fuel of choice for eliminating the dependency on petroleum. DME can be used as a clean high-efficiency compression ignition fuel with reduced NO x, SO x, and particulate matter, it can be efficiently reformed to hydrogen at low temperatures, and does not have large issues with toxicity, production, infrastructure, and transportation as do various other fuels. The literature relevant to DME use is reviewed and summarized to demonstrate the viability of DME as an alternative fuel.

  6. Future trends in image coding

    Science.gov (United States)

    Habibi, Ali

    1993-01-01

    The objective of this article is to present a discussion on the future of image data compression in the next two decades. It is virtually impossible to predict with any degree of certainty the breakthroughs in theory and developments, the milestones in advancement of technology and the success of the upcoming commercial products in the market place which will be the main factors in establishing the future stage to image coding. What we propose to do, instead, is look back at the progress in image coding during the last two decades and assess the state of the art in image coding today. Then, by observing the trends in developments of theory, software, and hardware coupled with the future needs for use and dissemination of imagery data and the constraints on the bandwidth and capacity of various networks, predict the future state of image coding. What seems to be certain today is the growing need for bandwidth compression. The television is using a technology which is half a century old and is ready to be replaced by high definition television with an extremely high digital bandwidth. Smart telephones coupled with personal computers and TV monitors accommodating both printed and video data will be common in homes and businesses within the next decade. Efficient and compact digital processing modules using developing technologies will make bandwidth compressed imagery the cheap and preferred alternative in satellite and on-board applications. In view of the above needs, we expect increased activities in development of theory, software, special purpose chips and hardware for image bandwidth compression in the next two decades. The following sections summarize the future trends in these areas.

  7. Outlook for alternative energy sources. [aviation fuels

    Science.gov (United States)

    Card, M. E.

    1980-01-01

    Predictions are made concerning the development of alternative energy sources in the light of the present national energy situation. Particular emphasis is given to the impact of alternative fuels development on aviation fuels. The future outlook for aircraft fuels is that for the near term, there possibly will be no major fuel changes, but minor specification changes may be possible if supplies decrease. In the midterm, a broad cut fuel may be used if current development efforts are successful. As synfuel production levels increase beyond the 1990's there may be some mixtures of petroleum-based and synfuel products with the possibility of some shale distillate and indirect coal liquefaction products near the year 2000.

  8. Titin Diversity—Alternative Splicing Gone Wild

    Directory of Open Access Journals (Sweden)

    Wei Guo

    2010-01-01

    Full Text Available Titin is an extremely large protein found in highest concentrations in heart and skeletal muscle. The single mammalian gene is expressed in multiple isoforms as a result of alternative splicing. Although titin isoform expression is controlled developmentally and in a tissue specific manner, the vast number of potential splicing pathways far exceeds those described in any other alternatively spliced gene. Over 1 million human splice pathways for a single individual can be potentially derived from the PEVK region alone. A new splicing pattern for the human cardiac N2BA isoform type has been found in which the PEVK region includes only the N2B type exons. The alterations in splicing and titin isoform expression in human heart disease provide impetus for future detailed study of the splicing mechanisms for this giant protein.

  9. Alternative aviation turbine fuels

    Science.gov (United States)

    Grobman, J.

    1977-01-01

    The efficient utilization of fossil fuels by future jet aircraft may necessitate the broadening of current aviation turbine fuel specifications. The most significant changes in specifications would be an increased aromatics content and a higher final boiling point in order to minimize refinery energy consumption and costs. These changes would increase the freezing point and might lower the thermal stability of the fuel and could cause increased pollutant emissions, increased smoke and carbon formation, increased combustor liner temperatures, and poorer ignition characteristics. This paper discusses the effects that broadened specification fuels may have on present-day jet aircraft and engine components and the technology required to use fuels with broadened specifications.

  10. Testing alternate gravitational theories

    Science.gov (United States)

    Standish, E. M.

    2010-01-01

    The planetary ephemerides are used to examine different suggested forms of the gravitational equations of motion which could possibly cause the observed Pioneer Anomaly. It is shown that most of the forms would be unacceptable, including that generally assumed - a constant acceleration directed toward the Sun. The tests show that three other forms could not exist within 10 au's of the Sun. Only one suggested form would be compatible with the Pioneer Anomaly affecting Saturn or any other more inward planet. Additional planetary observations in the future may possibly eliminate this form also.

  11. Alternative Threat Methodology

    Directory of Open Access Journals (Sweden)

    Charles B. King III

    2011-01-01

    Full Text Available Of the many challenges facing risk analysis practitioners, perhaps the most difficult to overcome is in the field of terrorist threat analysis. When estimating the threat associated with naturally occurring events, historical data provides a great deal of insight into the frequency of those events. Threat associated with accidents applies many operations research tools to gauge future failure-rates (Failure Mode and Effects Analysis being perhaps the most widely known. However, estimating the probability of an individual's or group's attacking a specific (or even a generic target is an element of risk analysis in which art and intuition are applied far more regularly than is science.

  12. Altern als Widerstand

    Directory of Open Access Journals (Sweden)

    Roberta Maierhofer

    2005-07-01

    Full Text Available Gullettes kulturwissenschaftliche Untersuchung Aged by Culture ist wie bereits ihre zwei vorangehenden Werke, die sich mit Altern beschäftigen – Safe at Last in the Middle Years: The Invention of the Midlife Progress Novel (1988 und Declining to Decline. Cultural Combat and the Politics of the Middle (1997 –, von großem persönlichen Engagement und durch ein politisches Anliegen motiviert. Sowohl die Dringlichkeit als auch der Widerstand, den Gullette, die sich als „age critic“ definiert, als moralische und politische Notwendigkeit postuliert, werden in der Zweiteilung der Abhandlung angesprochen: „Cultural Urgencies“ und „Theorizing Age Resistantly“. Während Gullette den Begriff „aged by culture“ bereits in Declining to Decline einführt, stellt sie ihn nun in den Mittelpunkt ihrer Untersuchung. Das Buch ist einerseits einer gesellschaftspolitischen Analyse der USA gewidmet, andererseits wird eine Theorie des Widerstands gegenüber Altersdiskriminierung entwickelt.

  13. Alternate Reality Games

    DEFF Research Database (Denmark)

    Kristiansen, Erik

    2014-01-01

    What. Urban Games are games that take place in the real-world of the players, and which make use of the properties of the city. Alternate Reality Games (ARGs) are urban games that pretend to be conspiracy theories that really are happening in the life of the players. The games are experienced...... through events, challenges and collaborative puzzle solving and may evolve through the engagement of the players. This new design method, Aulaia, addresses the design of urban games in the form of ARGs. Along with the design method several examples from real world ARGs are given. Why. ARGs and other urban...... games are usually large and complicated undertakings, which require many coordinated activities in order to make successful games. This design method secures a structured approach, not only for the design of the game, but also for the launch and running. ARGs develop along with the players and require...

  14. Alternatives to neoliberalism?

    DEFF Research Database (Denmark)

    Warring, Niels; Ahrenkiel, Annegrethe; Nielsen, Birger Steen;

    This paper will discuss the consequences of neoliberal governance in Danish day care centres, the social educators’ response, and the possible development of alternatives based on collective participation of social educators and union representatives. We will show how important and unnoticed...... professional competencies come under pressure, and how collective interest representation is challenged. We will discuss how concepts of “gestural knowledge”, “coherence” and “rhythm” open for a new understanding of professional competence. And we will conclude that the social educators and their unions have...... the possibility to contribute to the development of a new welfare paradigm. The paper is based on material from two research projects (Ahrenkiel et al. 2009, 2011) involving social educators and union representatives in day care institutions. We have observed everyday work activities in day care centres...

  15. Multimedia communications: architectural alternatives

    Science.gov (United States)

    McGarty, Terrence P.; Treves, S. T.

    1992-03-01

    Multimedia communications systems are a combination of human interfaces and end users interacting with multimedia data bases and highly disparate but interconnected communications networks. This paper discusses several architectural alternatives and system requirements that will assist in the design and development of MMCS in actual environments. The approaches taken in this paper are based upon the development of such systems in both medical and printing and publishing environments. This paper develops several key concepts as how best to define and structure data in a multimedia environment, how best to integrate the communications elements, and how best to permit the maximum flexibility to the end user to utilize the system's capabilities in the context of a fully conversational environment.

  16. Diagnostic Plausibility of MTBDRplus and MTBDRsl Line Probe Assays for Rapid Drug Susceptibility Testing of Drug Resistant Mycobacterium tuberculosis Strains in Pakistan

    Directory of Open Access Journals (Sweden)

    Javaid

    2016-06-01

    Full Text Available Background World health organization (WHO recommends the use of line probe assays (LiPAs for rapid drug susceptibility testing (DST. However, only a limited number of studies from Pakistan have documented the performance characteristics of line probe assays in testing multi-drug resistant (MDR strains of Mycobacterium tuberculosis (MTB. Objectives The objective of this work is to evaluate the diagnostic plausibility of the LiPA tests MTBDRplus and MTBDRsl on MDR MTB isolates from Pakistan. Patients and Methods This was a cross-sectional study conducted at the Indus hospital, Karachi. LiPA testing was performed on 196 smear-positive samples using BACTEC MGIT 960 as a gold standard. Results The sensitivity of MTBDRplus for isoniazid and rifampicin was found to be 88.8% and 90.2%, respectively, while sensitivity of MTBDRsl for fluoroquinolones, amikacin/capreomycin, and ethambutol was found to be 72.9%, 81.8%, and 56.6%, respectively. Conclusions The MTBDRplus and MTBDRsl genotypic testing can serve as useful additional tools for DST in a high-burden country like Pakistan provided it is used in combination with phenotypic testing.

  17. Observational evidence for the plausible linkage of Equatorial Electrojet (EEJ electric field variations with the post sunset F-region electrodynamics

    Directory of Open Access Journals (Sweden)

    V. Sreeja

    2009-11-01

    Full Text Available The paper is based on a detailed observational study of the Equatorial Spread F (ESF events on geomagnetically quiet (Ap≤20 days of the solar maximum (2001, moderate (2004 and minimum (2006 years using the ionograms and magnetograms from the magnetic equatorial location of Trivandrum (8.5° N; 77° E; dip lat ~0.5° N in India. The study brings out some interesting aspects of the daytime Equatorial Electrojet (EEJ related electric field variations and the post sunset F-region electrodynamics governing the nature of seasonal characteristics of the ESF phenomena during these years. The observed results seem to indicate a plausible linkage of daytime EEJ related electric field variations with pre-reversal enhancement which in turn is related to the occurrence of ESF. These electric field variations are shown to be better represented through a parameter, termed as "E", in the context of possible coupling between the E- and F-regions of the ionosphere. The observed similarities in the gross features of the variations in the parameter "E" and the F-region vertical drift (Vz point towards the potential usage of the EEJ related parameter "E" as an useful index for the assessment of Vz prior to the occurrence of ESF.

  18. Effect of central metal ions of analogous metal-organic frameworks on adsorption of organoarsenic compounds from water: plausible mechanism of adsorption and water purification.

    Science.gov (United States)

    Jun, Jong Won; Tong, Minman; Jung, Beom K; Hasan, Zubair; Zhong, Chongli; Jhung, Sung Hwa

    2015-01-02

    The adsorptive removal of organoarsenic compounds such as p-arsanilic acid (ASA) and roxarsone (ROX) from water using metal-organic frameworks (MOFs) has been investigated for the first time. A MOF, iron benzenetricarboxylate (also called MIL-100-Fe) exhibits a much higher adsorption capacity for ASA and ROX than activated carbon, zeolite (HY), goethite, and other MOFs. The adsorption of ASA and ROX over MIL-100-Fe is also much more rapid than that over activated carbon. Moreover, the used MIL-100-Fe can be recycled by simply washing with acidic ethanol. Therefore, it is determined that a MOF such as MIL-100-Fe can be used to remove organoarsenic compounds from contaminated water because of its high adsorption capacity, rapid adsorption, and ready regeneration. Moreover, only one of three analogous MIL-100 species (MIL-100-Fe, rather than MIL-100-Al or MIL-100-Cr) can effectively remove the organoarsenic compounds. This selective and high adsorption over MIL-100-Fe, different from other analogous MIL-100 species, can be explained (through calculations) by the facile desorption of water from MIL-100-Fe as well as the large (absolute value) replacement energy (difference between the adsorption energies of the organoarsenic compounds and water) exhibited by MIL-100-Fe. A plausible adsorption/desorption mechanism is proposed based on the surface charge of the MOFs, FTIR results, calculations, and the reactivation results with respect to the solvents used in the experiments.

  19. Investigation of plausible mechanistic pathways in hydrogenation of η⁵-(C₅H₅)₂Ta(H)=CH₂: an analysis using DFT and AIM techniques.

    Science.gov (United States)

    Neogi, Soumya Ganguly; Das, Anita; Chaudhury, Pinaki

    2014-03-01

    In this manuscript, we investigate two plausible pathways for addition of H₂ across the bond Ta=C in η⁵-(C₅H₅)₂Ta(H)=CH₂. One of the investigated reaction pathways involves a single concerted step with a four-membered transition state keeping the oxidation state of tantalum unaltered, where as the other pathway deals with a two step reaction with α-insertion of H₂ to produce a 16e⁻ Ta(III)-methyl species and a subsequent oxidative addition. We must emphasize that an experimental study by Bregel et al. [J Am Chem Soc 2002, 124:13827-13832] on a derivative of the investigated chemical system in the present study showed that the two step strategy of α-insertion followed by subsequent oxidative addition is the preferred one. Our numerical investigations using DFT and AIM calculations lead to a similar conclusion. To establish our conclusion, we employ various basis sets to obtain the free energy of activation of the reaction. The AIM technique especially helps us to characterize the bond critical points at the optimized geometries of the reactants, products, transition states, and intermediates for the two step mechanism.

  20. Untemplated nonenzymatic polymerization of 3',5'cGMP: a plausible route to 3',5'-linked oligonucleotides in primordia.

    Science.gov (United States)

    Šponer, Judit E; Šponer, Jiří; Giorgi, Alessandra; Di Mauro, Ernesto; Pino, Samanta; Costanzo, Giovanna

    2015-02-19

    The high-energy 3',5' phosphodiester linkages conserved in 3',5' cyclic GMPs offer a genuine solution for monomer activation required by the transphosphorylation reactions that could lead to the emergence of the first simple oligonucleotide sequences on the early Earth. In this work we provide an in-depth characterization of the effect of the reaction conditions on the yield of the polymerization reaction of 3',5' cyclic GMPs both in aqueous environment as well as under dehydrating conditions. We show that the threshold temperature of the polymerization is about 30 °C lower under dehydrating conditions than in solution. In addition, we present a plausible exergonic reaction pathway for the polymerization reaction, which involves transient formation of anionic centers at the O3' positions of the participating riboses. We suggest that excess Na(+) cations inhibit the polymerization reaction because they block the anionic mechanism via neutralizing the negatively charged O3'. Our experimental findings are compatible with a prebiotic scenario, where gradual desiccation of the environment could induce polymerization of 3',5' cyclic GMPs synthesized in liquid.