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Sample records for plasticity xilin lu

  1. Tectonic significance of the Xilin Gol Complex, Inner Mongolia, China: Petrological, geochemical and U–Pb zircon age constraints

    NARCIS (Netherlands)

    Li, Y.; Zhou, H; Brouwer, F.M.; Wijbrans, J.R.; Zhong, Z.; Liu, H.

    2011-01-01

    The Xilin Gol Complex, consisting of strongly deformed and metamorphosed rocks, is exposed as a large tectonic unit within the Central-Asian Orogenic Belt (CAOB). It is located on the Xilinhot-Sonidzuoqi north-dipping thrust belt and near the Solonker suture zone that is widely regarded to record

  2. [Major ion chemistry of surface water in the Xilin River Basin and the possible controls].

    Science.gov (United States)

    Tang, Xi-Wen; Wu, Jin-Kui

    2014-01-01

    Under the increasing pressure of water shortage and steppe degradation, information on the hydrological cycle in the steppe region in Inner Mongolia is urgently needed. Major ions are widely used to identify the hydrological processes in a river basin. Based on the analysis results of 239 river water samples collected in 13 sections along the Xilin River system during 2006 to 2008, combined with data from groundwater and precipitation samples collected in the same period and the meteorological and hydrological data in the Xilin River Basin, hydrochemical characteristics and the chemistry of major ions of the Xilin River water have been studied by means of Piper triangle plots and Gibbs diagrams. The results showed that: (1) the total dissolved solid (TDS) in river water mainly ranged between 136.7 mg x L(-1) and 376.5 mg x L(-1), and (2) it had an increasing trend along the river flow path. (3) The major cations and anions of river water were Ca2+ and HCO3-, respectively, and the chemical type of the river water varied from HCO3- -Ca2+ in the headwater area to HCO(3-)-Ca2+ Mg2+ in the lower part. (4) The variation in the concentration of major irons in surface water was not significant at the temporal scale. Usually, the concentration values of major irons were much higher in May than those in other months during the runoff season, while the values were a bit lower in 2007 than those in 2006 and 2008. Except for SO4(2-), the concentrations of other ions such as Ca2+, Na+, Mg2+, K+, Cl- and HCO3- showed a upward trend along the river flow path. Comparing major ion concentrations of the river water with those of local groundwater and precipitation, the concentration in river water was between those of precipitation and groundwater but was much closer to the concentration of groundwater. This indicated that the surface water was recharged by a mixture of precipitation and groundwater, and groundwater showed a larger impact. The Gibbs plot revealed that the chemical

  3. Plastic

    International Nuclear Information System (INIS)

    Jeong Gi Hyeon

    1987-04-01

    This book deals with plastic, which includes introduction for plastic, chemistry of high polymers, polymerization, speciality and structure of a high molecule property of plastic, molding, thermosetting plastic, such as polyethylene, polyether, polyamide and polyvinyl acetyl, thermal plastic like phenolic resins, xylene resins, melamine resin, epoxy resin, alkyd resin and poly urethan resin, new plastic like ionomer and PPS resin, synthetic laminated tape and synthetic wood, mixed materials in plastic, reprocessing of waste plastic, polymer blend, test method for plastic materials and auxiliary materials of plastic.

  4. Fundamental study of inorganic-organic hybrid scintillator using Pr:Lu.sub.3./sub.Al.sub.5./sub.O.sub.12./sub. and plastic scintillator

    Czech Academy of Sciences Publication Activity Database

    Kamada, K.; Kurosawa, S.; Yokota, Y.; Yanagida, T.; Nikl, Martin; Yoshikawa, A.

    2014-01-01

    Roč. 53, č. 4 (2014), "04EH10-1"-"04EH10-4" ISSN 0021-4922 Institutional support: RVO:68378271 Keywords : scintillators * Pr:LuAG * luminescence Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.127, year: 2014

  5. Memories of Lu Jingqing

    Institute of Scientific and Technical Information of China (English)

    1994-01-01

    Lu Jingqing was a woman of letters who wrote poems when she was young and also worked as an editor and teacher. Her main works are Women poets of the Tang Dynasty (1931), Whisper (a collection of poems, 1932), Plain Writing (a collection of verses, 1930) and The Wandering (1933). In March 1993, 86-year-old Lu Jingqing, Professor of the Shanghai College of Finance and Economics, died in Shanghai. Zhu Bokang, an old friend of Lu and her husband wrote the following article in her memory.

  6. Evidence for a magnetic moment at the Lu site of LuFe2

    International Nuclear Information System (INIS)

    Kasamatsu, Y.; Armitage, J.G.M.; Lord, J.S.; Riedi, P.C.; Fort, D.

    1995-01-01

    High pressure 175 Lu NMR measurements of LuFe 2 at 4.2 K suggest that Lu, like Y and Zr, carries a negative magnetic moment, in agreement with self-consistent energy band calculations. The observed spectrum is more complicated than would be expected for a Laves phase compound. ((orig.))

  7. Hybrid synchronization of hyperchaotic Lu system

    Indian Academy of Sciences (India)

    In this paper, we study the hybrid synchronization between two identical hyperchaotic Lu systems. Hybrid synchronization of hyperchaotic Lu system is achieved through synchronization of two pairs of states and anti-synchronization of the other two pairs of states. Active controls are designed to achieve hybrid ...

  8. Evaluation of the 175Lu(n,2n)174Lu, 175Lu(n,2n/sup 174m/Lu, and 175Lu(n,3n)173Lu cross sections from threshold to 20 MeV

    International Nuclear Information System (INIS)

    Philis, C.; Young, P.G.; Arthur, E.D.

    1978-04-01

    An evaluation of the 175 Lu(n,2n) 174 Lu, 175 Lu(n,2n)/sup 174m/Lu, and 175 Lu(n,3n) 173 Lu reactions from threshold to 20 MeV is presented. Available experimental data were renormalized to a consistent set of standards and were used along with results from statistical-preequilibrium model calculations to produce recommended curves for each of these reactions

  9. lu sildistamine / Erkki Bahovski

    Index Scriptorium Estoniae

    Bahovski, Erkki, 1970-

    2007-01-01

    President Toomas Hendrik Ilvese üleskutsest moodustada Mälu Instituut Eesti lähimineviku uurimiseks. Autori arvates on Vene propaganda taustal raske uurida ajalugu sine ira et studio ("ilma viha ja eelarvamusteta"), nagu soovitas president

  10. Advances on LuGre friction model

    OpenAIRE

    Fuad, Mohammad; Ikhouane, Fayçal

    2013-01-01

    LuGre friction model is an ordinary differential equation that is widely used in describing the friction phenomenon for mechanical systems. The importance of this model comes from the fact that it captures most of the friction behavior that has been observed including hysteresis. In this paper, we study some aspects related to the hysteresis behavior induced by the LuGre friction model.

  11. lu defragmenteerimine / Ilja Sundelevitsh

    Index Scriptorium Estoniae

    Sundelevitsh, Ilja

    2007-01-01

    Viktor Misiano kureeritud projekt "Mälu tagasitulek" Kumu Kunstimuuseumis kuni 29. VII. Dmitri Gutovi projektist, mis koosneb videotest "Sula" ja "Kajakad" ning kolmest maalist, Valentin Arhipovi projektist "Vassili Grigorjevitsh Arhipovi looming aastail 1962-2006", Juri Leidermani heliinstallatsioonist "Isa jutustus", Jevgeni Fiksi projektist, Gljuklja & Tzaplja (Olga Jegorova, Natalja Pershina) installatsioonist "Punased purjed", Igor Shtsherbini tööst "Defragmenteerimine. Stirlitzi mälu" ja Sergei Bratkovi tööst

  12. Radiation hardness of LuAG:Ce and LuAG:Pr scintillator crystals

    CERN Document Server

    Derdzyan, M V; Belsky, A; Dujardin, C; Lecoq, P; Lucchini, M; Ovanesyan, K L; Pauwels, K; Pedrini, C; Petrosyan, A G

    2012-01-01

    Single crystals of LuAG:Ce, LuAG:Pr and un-doped LuAG were grown by the vertical Bridgman method and studied for radiation hardness under gamma-rays with doses in the range 10-10(5) Gy (Co-60). A wide absorption band peaking at around 600 nm springs up in all three types of crystals after the irradiations. The second band peaking at around 375 nm appears in both LuAG:Pr and un-doped LuAG. Compositional variations have been done to reveal the spectral behavior of induced color centers in more detail and to understand their origin. Similarities in behavior of Yb2+ centers in as-grown garnets are found, indicating that radiation induced color centers can be associated with residual trace amounts of Yb present in the raw materials. Un-doped LuAG and LuAG:Ce demonstrate moderate radiation hardness (the induced absorption coefficients being equal to 0.05-0.08 cm(-1) for accumulated doses of 10(3)-10(4) Gy), while LuAG:Pr is less radiation hard. The ways to improve the radiation hardness are discussed.

  13. Plastic Surgery

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Plastic Surgery KidsHealth / For Teens / Plastic Surgery What's in ... her forehead lightened with a laser? What Is Plastic Surgery? Just because the name includes the word " ...

  14. Spectral properties of hydrothermally-grown Nd:LuAG, Yb:LuAG, and Yb:Lu{sub 2}O{sub 3} laser materials

    Energy Technology Data Exchange (ETDEWEB)

    Brown, David C., E-mail: DBrown@snakecreeklasers.com [Snake Creek Lasers LLC, Friendsville, PA 18818 (United States); McMillen, Colin D.; Moore, Cheryl; Kolis, Joseph W. [Department of Chemistry and Center for Optical Materials Science and Engineering Technologies, Clemson University, Clemson, SC 29634-0973 (United States); Envid, Victoria [Snake Creek Lasers LLC, Friendsville, PA 18818 (United States)

    2014-04-15

    We have investigated the hydrothermal growth of, and spectrally characterized, the lutetium based laser materials Nd:LuAG, Yb:LuAG, and Yb:Lu{sub 2}O{sub 3}. Absorption cross-section data are presented for Nd:LuAG at 83, 175, and 295 K. Absorption cross-section data was also obtained for Yb:LuAG at 83, 175, and 295 K; the 295 K data was used to generate emission cross-sections using the method of reciprocity. For Yb:Lu{sub 2}O{sub 3}, we present absorption cross-sections at 295 K as well as emission cross-sections derived using reciprocity. -- Highlights: • We present spectral properties for hydrothermally-grown laser crystals. • Absorption cross-section data are presented for Nd:LuAG and Yb:LuAG at 83, 175, and 295 K. • Emission cross-sections are presented for Yb:LuAG at 295 K derived by reciprocity. • We present absorption cross-sections at 295 K as well as emission cross-sections derived using reciprocity for the laser material Yb:Lu{sub 2}O{sub 3}.

  15. Luminescent properties of LuPO4-Pr and LuPO4-Eu nanoparticles

    International Nuclear Information System (INIS)

    Vistovskyy, V.; Malyi, T.; Vas’kiv, A.; Chylii, M.; Mitina, N.; Zaichenko, A.; Gektin, A.; Voloshinovskii, A.

    2016-01-01

    Spectral-luminescence parameters of LuPO 4 -Eu and LuPO 4 -Pr nanoparticles of different sizes are studied upon excitation by the synchrotron radiation with photon energies 4–40 eV. Influence of the nanoparticle size on Eu 3+ and Pr 3+ impurity luminescence is analyzed for intracenter and recombination excitation. It is shown that the luminescence intensity of impurities in the case of recombination excitation significantly stronger decreases with decreasing of nanoparticle size compared to intracenter excitation. This feature is explained by the influence of thermalization length to nanoparticle size ratio on the recombination luminescence. Electron recombination luminescence inherent for LuPO 4 -Eu nanoparticles shows a weaker dependence on the nanoparticle size than the hole one in LuPO 4 -Pr nanoparticles. The difference between energy states of praseodymium impurity ions in nanoparticles of different sizes is revealed.

  16. LU factorization for accelerator-based systems

    KAUST Repository

    Agullo, Emmanuel

    2011-12-01

    Multicore architectures enhanced with multiple GPUs are likely to become mainstream High Performance Computing (HPC) platforms in a near future. In this paper, we present the design and implementation of an LU factorization using tile algorithm that can fully exploit the potential of such platforms in spite of their complexity. We use a methodology derived from previous work on Cholesky and QR factorizations. Our contributions essentially consist of providing new CPU/GPU hybrid LU kernels, studying the impact on performance of the looking variants as well as the storage layout in presence of pivoting, tuning the kernels for two different machines composed of multiple recent NVIDIA Tesla S1070 (four GPUs total) and Fermi-based S2050 GPUs (three GPUs total), respectively. The hybrid tile LU asymptotically achieves 1 Tflop/s in single precision on both hardwares. The performance in double precision arithmetic reaches 500 Gflop/s on the Fermi-based system, twice faster than the old GPU generation of Tesla S1070. We also discuss the impact of the number of tiles on the numerical stability. We show that the numerical results of the tile LU factorization will be accurate enough for most applications as long as the computations are performed in double precision arithmetic. © 2011 IEEE.

  17. Structure of wobbling excitations in 163Lu

    International Nuclear Information System (INIS)

    Carlsson, B.G.

    2007-01-01

    Using a many-particles plus rotor model, wobbling excitations built on top of a triaxial superdeformed band in 163 Lu are investigated. By extracting all parameters for the rotor from a mean field calculation a good correspondence with calculations based on the random-phase approximation is achieved. (author)

  18. ON LU FACTORIZATION ALGORITHM WITH MULTIPLIERS

    African Journals Online (AJOL)

    Various algorithm such as Doolittle, Crouts and Cholesky's have been proposed to factor a square matrix into a product of L and U matrices, that is, to find L and U such that A = LU; where L and U are lower and upper triangular matrices respectively. These methods are derived by writing the general forms of L and U and the ...

  19. Study of the production of 177Lu through 176Yb (n, γ) 177Yb → 177Lu nuclear reaction

    International Nuclear Information System (INIS)

    Silva, Giovana Pasqualini da; Osso Junior, Joao Alberto

    2007-01-01

    The beta minus emitter 177 Lu is a promising therapeutic radioisotope for the curative treatment of cancer using labelled proteins. It has a half - life of T 1/2 = 6.71 day and maximum and average β - energies of 421 and 133 keV, resulting in a short range of radiation in tissue. The decay is accompanied by the emission of low energy γ-radiation with 208.3 keV (11%) and 113 keV (6.4%) suitable for simultaneous imaging, 177 Lu can be produced by two different routes, namely, by irradiation of natural Lu 2 O 3 target ( 176 Lu, 2.6%) or enriched (in 176 Lu) Lu 2 O 3 target, as also by irradiation of Yb target (Yb 2 O 3 ) followed by radiochemical separation of 177 Lu from Yb isotopes. The objective of this work is to study the production of 177 Lu through the indirect 176 Yb(n,γ) 177 Yb → 177 Lu nuclear reaction. The results of the production yield of 177 Lu will be shown and compared with the direct reaction. The method of choice for the chemical separation between Lu and Yb was the ion exchange, using an cation exchange resin in Cl - form and α-HIBA as eluent. Preliminary results showed a good separation of 177 Lu from Yb 2 O 3 indirect targets. (author)

  20. Plasticity theory

    CERN Document Server

    Lubliner, Jacob

    2008-01-01

    The aim of Plasticity Theory is to provide a comprehensive introduction to the contemporary state of knowledge in basic plasticity theory and to its applications. It treats several areas not commonly found between the covers of a single book: the physics of plasticity, constitutive theory, dynamic plasticity, large-deformation plasticity, and numerical methods, in addition to a representative survey of problems treated by classical methods, such as elastic-plastic problems, plane plastic flow, and limit analysis; the problem discussed come from areas of interest to mechanical, structural, and

  1. CW laser properties of Nd:GdYAG, Nd:LuYAG, and Nd:GdLuAG mixed crystals

    Science.gov (United States)

    Di, J. Q.; Xu, X. D.; Li, D. Z.; Zhou, D. H.; Wu, F.; Zhao, Z. W.; Xu, J.; Tang, D. Y.

    2011-10-01

    Three mixed crystals, Nd:GdYAG, Nd:LuYAG, and Nd:GdLuAG, were grown by Czochralski method. We report the continuous-wave (CW) Nd:GdYAG, Nd:LuYAG, and Nd:GdLuAG laser operation under laser diode pumping. The maximum output powers are 4.11, 5.31, and 7.47 W, with slope efficiency of 73.0, 55.3, and 57.1%, respectively. With replacing Lu3+ or Y3+ ions with large Gd3+ ions, the pump efficiency increases.

  2. Hydrogen migration in Lu at low temperatures

    International Nuclear Information System (INIS)

    Yamakawa, K.

    1997-01-01

    The migration of hydrogen in Lu is determined by electrical resistance measurements in temperature range of 140-170 K. Disordered hydrogen atoms, which are formed by quenching, migrate to order during annealing in the above temperature range. The rate of the resistance decrease depends on the ordering rate of hydrogen. From the resistance decrease during isothermal annealings, the activation energy of hydrogen migration is determined as 0.43 eV (41.5 kJ mol -1 ). (orig.)

  3. Late night activity regarding stroke codes: LuNAR strokes.

    Science.gov (United States)

    Tafreshi, Gilda; Raman, Rema; Ernstrom, Karin; Rapp, Karen; Meyer, Brett C

    2012-08-01

    There is diurnal variation for cardiac arrest and sudden cardiac death. Stroke may show a similar pattern. We assessed whether strokes presenting during a particular time of day or night are more likely of vascular etiology. To compare emergency department stroke codes arriving between 22:00 and 8:00 hours (LuNAR strokes) vs. others (n-LuNAR strokes). The purpose was to determine if late night strokes are more likely to be true strokes or warrant acute tissue plasminogen activator evaluations. We reviewed prospectively collected cases in the University of California, San Diego Stroke Team database gathered over a four-year period. Stroke codes at six emergency departments were classified based on arrival time. Those arriving between 22:00 and 8:00 hours were classified as LuNAR stroke codes, the remainder were classified as 'n-LuNAR'. Patients were further classified as intracerebral hemorrhage, acute ischemic stroke not receiving tissue plasminogen activator, acute ischemic stroke receiving tissue plasminogen activator, transient ischemic attack, and nonstroke. Categorical outcomes were compared using Fisher's Exact test. Continuous outcomes were compared using Wilcoxon's Rank-sum test. A total of 1607 patients were included in our study, of which, 299 (19%) were LuNAR code strokes. The overall median NIHSS was five, higher in the LuNAR group (n-LuNAR 5, LuNAR 7; P=0·022). There was no overall differences in patient diagnoses between LuNAR and n-LuNAR strokes (P=0·169) or diagnosis of acute ischemic stroke receiving tissue plasminogen activator (n-LuNAR 191 (14·6%), LuNAR 42 (14·0%); P=0·86). Mean arrival to computed tomography scan time was longer during LuNAR hours (n-LuNAR 54·9±76·3 min, LuNAR 62·5±87·7 min; P=0·027). There was no significant difference in 90-day mortality (n-LuNAR 15·0%, LuNAR 13·2%; P=0·45). Our stroke center experience showed no difference in diagnosis of acute ischemic stroke between day and night stroke codes. This

  4. Phase equilibria and crystalline structure of compounds in the Lu-Al and Lu-Cu-Al systems

    International Nuclear Information System (INIS)

    Kuz'ma, Yu.B.; Stel'makhovich, B.M.; Galamushka, L.I.

    1992-01-01

    Phase equilibria and crystal structure of compounds in Lu-Al and Lu-Cu-Al systems were studied. Existence of Lu 2 Al compound having the structure of the PbCl 2 type is ascertained. Diagram of phase equilibria of Lu-Cu-Al system at 870 K is plotted. Compounds Lu 2 (Cu,Al) 17 (the Th 2 Zn 17 type structure), Lu(Cu,Al) 5 (CaCu 5 type structure), Lu 6 (Cu,Al) 23 (Th 6 Mn 23 type structure) and ∼ LuCuAl 2 have been prepared for the first time. Investigation of component interaction in Lu-Cu-Al system shows that the system is similar to previously studied systems Dy-Cu-Al and Er-Cu-Al. The main difference consists in the absence of LuCuAl 3 compound with rhombic structure of the CeNi 2+x Sb 2-x type in the system investigated

  5. High spin K isomeric target of 177mLu

    International Nuclear Information System (INIS)

    Roig, O.; Belier, G.; Daugas, J.-M.; Delbourgo, P.; Maunoury, L.; Meot, V.; Morichon, E.; Sauvestre, J.-E.; Aupiais, J.; Boulin, Y.; Fioni, G.; Letourneau, A.; Marie, F.; Ridikas, D.

    2004-01-01

    The techniques used to produce a 177m Lu (J π =23/2 - ,T 1/2 =160.4 days) target are described in this paper. Firstly, an isotopic separation of an enriched lutetium sample was used to reach a purity of 176 Lu close to 99.993%. Afterwards, the high neutron flux of the Grenoble Institut Laue-Langevin reactor was used to produce the 177m Lu isomer by the 176 Lu(n,γ) reaction. Finally, a chemical separation was performed to extract 10 13 nuclei of 177m Lu. Thanks to this experiment, we have been able to estimate the destruction cross-section of the 177m Lu

  6. Time-dependent transcriptional response of GOT1 human small intestine neuroendocrine tumor after 177Lu[Lu]-octreotate therapy.

    Science.gov (United States)

    Spetz, Johan; Rudqvist, Nils; Langen, Britta; Parris, Toshima Z; Dalmo, Johanna; Schüler, Emil; Wängberg, Bo; Nilsson, Ola; Helou, Khalil; Forssell-Aronsson, Eva

    2018-05-01

    Patients with neuroendocrine tumors expressing somatostatin receptors are often treated with 177 Lu[Lu]-octreotate. Despite being highly effective in animal models, 177 Lu[Lu]-octreotate-based therapies in the clinical setting can be optimized further. The aims of the study were to identify and elucidate possible optimization venues for 177 Lu[Lu]-octreotate tumor therapy by characterizing transcriptional responses in the GOT1 small intestine neuroendocrine tumor model in nude mice. GOT1-bearing female BALB/c nude mice were intravenously injected with 15 MBq 177 Lu[Lu]-octreotate (non-curative amount) or mock-treated with saline solution. Animals were killed 1, 3, 7 or 41 d after injection. Total RNA was extracted from the tumor samples and profiled using Illumina microarray expression analysis. Differentially expressed genes were identified (treated vs. control) and pathway analysis was performed. Distribution of differentially expressed transcripts indicated a time-dependent treatment response in GOT1 tumors after 177 Lu[Lu]-octreotate administration. Regulation of CDKN1A, BCAT1 and PAM at 1 d after injection was compatible with growth arrest as the initial response to treatment. Upregulation of APOE and BAX at 3 d, and ADORA2A, BNIP3, BNIP3L and HSPB1 at 41 d after injection suggests first activation and then inhibition of the intrinsic apoptotic pathway during tumor regression and regrowth, respectively. Transcriptional analysis showed radiation-induced apoptosis as an early response after 177 Lu[Lu]-octreotate administration, followed by pro-survival transcriptional changes in the tumor during the regrowth phase. Time-dependent changes in cell cycle and apoptosis-related processes suggest different time points after radionuclide therapy when tumor cells may be more susceptible to additional treatment, highlighting the importance of timing when administering multiple therapeutic agents. Copyright © 2018 The Authors. Published by Elsevier Inc. All

  7. RDM lifetime measurement in 167Lu

    International Nuclear Information System (INIS)

    Rohilla, Aman; Gupta, C.K.; Chamoli, S.K.; Singh, R.P.; Muralithar, S.; Ashok Kumar; Govil, I.M.

    2014-01-01

    In this paper we are presenting the experiment performed for measuring lifetime in 167 Lu, which provides the measurement of the structural behavior of the nuclei due to single particle excitation. The enhanced γ-ray detection GDA setup present at IUAC was used and the data was acquired in the singles mode with the condition when any two of the BGO's element fire in coincidence with a Ge detector. The online data acquisition program CANDLE was used for data acquire in conjunction with CAMAC based data acquisition hardware

  8. 176Lu: Cosmic clock or stellar thermometer

    International Nuclear Information System (INIS)

    Ward, R.A.; Beer, H.; Kaeppeler, F.; Wisshak, K.

    1980-12-01

    We quantitatively examine the various experimental and theoretical aspects of the stellar synthesis of the long-lived ground state of 176 Lu (3.6 x 10 10 y). We discuss the various regimes of stellar temperature and free-neutron density in which either: (i) the internal electromagnetic couplings between 176 Lusup(o) and 176 Lusup(m) (3.68 hours) are sufficiently slow that they may be treated as separate nuclei, or (ii) the internal couplings are rapidly able to establish thermal equilibrium between 176 Lusup(o) and 176 Lusup(m). (orig.)

  9. lu Instituut uurib inimõiguste rikkumisi

    Index Scriptorium Estoniae

    2008-01-01

    President Toomas Hendrik Ilvese eestvedamisel asutati 20. sajandi teisel poolel Eestis toimunu põhjalikumaks uurimiseks Eesti Mälu Instituut. Ilmunud ka: Eesti Päevaleht (Stockholm) 14. veebr. 2008, lk. 2, pealk.: Mälu Instituut alustas tegevust; Vaba Eesti Sõna 7. veebr. 2008, lk. 12, pealk.: Under the leadership of President Ilves, the Memory Institute was established

  10. Neutron capture reactions on Lu isotopes at DANCE

    CERN Document Server

    Roig, O

    2010-01-01

    The DANCE (Detector for Advanced Neutron Capture Experiments) array located at the Los Alamos national laboratory has been used to obtain the neutron capture cross sections for 175Lu and 176Lu with neutron energies from thermal up to 100 keV. Both isotopes are of current interest for the nucleosynthesis s-process in astrophysics and for applications as in reactor physics or in nuclear medicine. Three targets were used to perform these measurements. One was natLu foil and the other two were isotope-enriched targets of 175Lu and 176Lu. The cross sections are obtained for now through a precise neutron flux determination and a normalization at the thermal neutron cross section value. A comparison with the recent experimental data and the evaluated data of ENDF/B-VII.0 will be presented. In addition, resonances parameters and spin assignments for some resonances will be featured.

  11. Production of 177Lu for targeted radionuclide therapy: Available options

    International Nuclear Information System (INIS)

    Dah, Ashutosh; Pillai, Maroor Raghavan Ambikalmajan; Knapp, Furn F. Jr.

    2015-01-01

    This review provides a comprehensive summary of the production of 177 Lu to meet expected future research and clinical demands. Availability of options represents the cornerstone for sustainable growth for the routine production of adequate activity levels of 177 Lu having the required quality for preparation of a variety of 177 Lu-labeled radiopharmaceuticals. The tremendous prospects associated with production of 177 Lu for use in targeted radionuclide therapy (TRT) dictate that a holistic consideration should evaluate all governing factors that determine its success. While both “direct” and “indirect” reactor production routes offer the possibility for sustainable 177 Lu availability, there are several issues and challenges that must be considered to realize the full potential of these production strategies. This article presents a mini review on the latest developments, current status, key challenges and possibilities for the near future. A broad understanding and discussion of the issues associated with 177 Lu production and processing approaches would not only ensure sustained growth and future expansion for the availability and use of 177 Lu-labeled radiopharmaceuticals, but also help future developments

  12. High spin states in 162Lu

    International Nuclear Information System (INIS)

    Gupta, S.L.; Pancholi, S.C.; Juneja, P.; Mehta, D.; Kumar, A.; Bhowmik, R.K.; Muralithar, S.; Rodrigues, G.; Singh, R.P.

    1997-01-01

    An experimental investigation of the odd-odd 162 Lu nucleus, following the 148 Sm( 19 F,5n) reaction at beam energy E lab =112MeV, has been performed through in-beam gamma-ray spectroscopy. It revealed three signature-split bands. The yrast band based on πh 11/2 circle-times νi 13/2 configuration exhibits anomalous signature splitting (the unfavored signature Routhian lying lower than the favored one) whose magnitude Δe ' ∼25keV, is considerably reduced in contrast to sizable normal signature splitting Δe ' ∼125 and 60 keV observed in the yrast πh 11/2 bands of the neighboring odd-A 161,163 Lu nuclei, respectively. The signature inversion in this band occurs at spin ∼20ℎ (frequency=0.37MeV). The second signature-split band, observed above the band crossing associated with the alignment of a pair of i 13/2 quasineutrons, is a band based on the four-quasiparticle [πh 11/2 [523]7/2 - times νh 9/2 [521]3/2 - times(νi 13/2 ) 2 ], i.e., EABA p (B p ), configuration. The third signature-split band is also likely to be a four-quasiparticle band with configuration similar to the second band but involving F quasineutron, i.e., FABA p (B p ). The experimental results are discussed in comparison with the existing data in the neighboring nuclei and in the framework of the cranking shell model. copyright 1997 The American Physical Society

  13. Plastic dosimeter

    International Nuclear Information System (INIS)

    Nagai, Shiro; Matsuda, Kohji.

    1988-01-01

    The report outlines major features and applications of plastic dosimeters. Some plastic dosimeters, including the CTA and PVC types, detect the response of the plastic material itself to radiations while others, such as pigment-added plastic dosimeters, contain additives as radiation detecting material. Most of these dosimeters make use of color centers produced in the dosimeter by radiations. The PMMA dosimeter is widely used in the field of radiation sterilization of food, feed and medical apparatus. The blue cellophane dosimeter is easy to handle if calibrated appropriately. The rad-color dosimeter serves to determine whether products have been irradiated appropriately. The CTA dosimeter has better damp proofing properties than the blue cellophane type. The pigment-added plastic dosimeter consists of a resin such as nylon, CTA or PVC that contains a dye. Some other plastic dosimeters are also described briefly. Though having many advantages, these plastic dosimeter have disadvantages as well. Some of their major disadvantages, including fading as well as large dependence on dose, temperature, humidity and anviroment, are discussed. (Nogami, K.)

  14. PLASTIC SURGERY

    African Journals Online (AJOL)

    Department of Plastic and Reconstructive Surgery Sefako Makgatho Health Science University, ... We report on a pilot study on the use of a circumareolar excision and the use of .... and 1 gynecomastia patient) requested reduction in NAC size.

  15. Plastic Fishes

    CERN Multimedia

    Trettnak, Wolfgang

    2015-01-01

    In terms of weight, the plastic pollution in the world’s oceans is estimated to be around 300,000 tonnes. This plastic comes from both land-based and ocean-based sources. A lecture at CERN by chemist Wolfgang Trettnak addressed this issue and highlighted the role of art in raising people’s awareness. The slideshow below gives you a taste of the artworks by Wolfgang Trettnak and Margarita Cimadevila.

  16. Blood clearance and occupational exposure for {sup 177}Lu-DOTATATE compared to {sup 177}Lu-PSMA radionuclide therapy

    Energy Technology Data Exchange (ETDEWEB)

    Abuqbeitah, Mohammad; Demir, Mustafa; Uslu-Besli, Lebriz; Yeyin, Nami; Soenmezoglu, Kerim [Istanbul University, Department of Nuclear Medicine, Cerrahpasa Faculty of Medicine, Istanbul (Turkey)

    2018-03-15

    The main target of this work is to examine blood clearance and external exposure for {sup 177}Lu-DOTATATE compared with new emerging {sup 177}Lu-PSMA therapy. Blood clearance and radiation exposure of 31 patients treated with 5.5 ± 1.1 GBq {sup 177}Lu-DOTATATE were compared to those of 23 patients treated with 7.4 GBq {sup 177}Lu-PSMA. Dose rates were measured at several distances and time points up to 120 h after treatment. Blood samples were collected conjunctively after infusion. Caregiver's cumulative dose was measured by means of an OSL (optically stimulated luminescence) dosimeter for 4-5 days and medical staff's dose was also estimated using electronic personal dosimeters. Finger dose was determined via ring TLD (Thermoluminescence Dosimeter) for radiopharmacists and nurses. Dose rates due to {sup 177}Lu-DOTATATE at a distance of 1 m, 4 h and 6 h after infusion, were 3.0 ± 2.8 and 2 ± 1.9 μSv/(h GBq), respectively, while those due to {sup 177}Lu-PSMA were 3.1 ± 0.8 and 2.2 ± 0.9 μSv/(h GBq). Total effective dose of 17 caregivers was 100-200 μSv for {sup 177}Lu-DOTATATE therapy. Mean effective doses to nurses and radiopharmacists were 5 and 4 μSv per patient, respectively, while those for physicists and physicians were 2 μSv per patient. For {sup 177}Lu-DOTATATE, effective half-life in blood and early elimination phase were 0.31 ± 0.13 and 4.5 ± 1 h, while they were found as 0.4 ± 0.1 and 5 ± 1 h, respectively, for {sup 177}Lu-PSMA. The first micturition time following {sup 177}Lu-DOTATATE infusion was noted after 36 ± 14 min, while the second and third voiding times were after 74 ± 9 and 128 ± 41 min, respectively. It is concluded that blood clearance and radiation exposure for {sup 177}Lu-DOTATATE are very similar to those for {sup 177}Lu-PSMA, and both treatment modalities are reasonably reliable for outpatient treatment, since the mean dose rate [2.1 μSv/(h GBq)] decreased below the dose rate that allows release of the patient

  17. SWGELLA DYSENTERIAE TYPE 1 IN KwAZuLU-NATAL

    African Journals Online (AJOL)

    -control. 1995: 15. ure co. LABORATORY SURV~ILLAN.CEOF. SWGELLA DYSENTERIAE TYPE 1 IN. KwAZuLU- ... freeze-dried quality-eontrol specimens were prepared containing ... (National Committee for Clinical Laboratory Standards,.

  18. Laulupidu, kultuurimälu ja rahvuslik identiteet / Marge Allandi

    Index Scriptorium Estoniae

    Allandi, Marge

    2012-01-01

    Artikkel on koostatud Marge Allandi magistritöö "Laulupidu kui rituaal: Eesti üldlaulupeod rahvusliku kultuurimälu ja identiteedi kujundajate ja kandjatena" põhjal, mis kaitsti Tallinna Ülikooli Eesti Humanitaarinstituudis 2009. aastal

  19. Alternative method to determine Specific Activity of (177)Lu by HPLC.

    Science.gov (United States)

    Breeman, Wouter A P; de Zanger, Rory M S; Chan, Ho Sze; de Blois, Erik

    2015-01-01

    Peptide Receptor Radionuclide Therapy (PRRT) with (177)Lu-DOTA-peptides requires (177)Lu with high specific activity (SA) and values >740 GBq (177)Lu per mg Lu to maximise the atom% of (177)Lu over total Lu. Vendors provide SA values which are based on activity and mass of the target, whereas due to "burn-up" of target, these SA values are not accurate. For a radiochemist the SA of (177)Lu is of interest prior to radiolabeling. An alternative method to determine SA was developed by HPLC, which includes a metal titration of a known amount of DOTA-peptide with a known amount of activity ((177)Lu), and a unknown amount of metal ((177+nat)Lu). Based on an HPLC separation of radiometal-DOTA-peptide and DOTA-peptide, and the concordant ratio of these components the metal content ((177+nat)Lu) can be calculated, and eventually the SA of (177)Lu can be accurately determined. These experimentally determined SA values exceeded the estimated values provided by vendors by 27 ± 16%, (range 6-73 %). The deviation of SA values for samples from the same Lu batch was <2% (n ≥ 10). the SA of (177)Lu is apparently often higher as stated by vendors in comparison to the experimentally determined actual values. For this reason, the SA of (177)Lu-DOTA-TATE and other Lu-DOTA-peptides could be increased accordingly.

  20. Experimental half-life determination of 176Lu

    International Nuclear Information System (INIS)

    Kossert, Karsten; Jörg, Gerhard; Gostomski, Christoph Lierse v.

    2013-01-01

    The half-life of the naturally occurring long-lived rare earth isotope 176 Lu was determined by a combination of highly sophisticated experimental procedures in order to further improve the reliability and the precision of literature data. The amount of lutetium in the samples was determined by inductively coupled plasma optical emission spectrometry (ICP-OES) using a NIST reference standard. The isotopic ratio N( 176 Lu)/N(Lu) in the samples was measured by means of inductively coupled plasma high resolution mass spectrometry (ICP-HRMS). The activity divided by the mass of Lu was determined by applying liquid scintillation (LS) counting. The LS counting efficiency of the beta/gamma emitter 176 Lu was determined with the CIEMAT/NIST efficiency tracing technique with low uncertainty. The influences of colour quenching and background effects are discussed in this paper. The half-life was found to be 3.640(35)×10 10 y. The result is in good agreement with other evaluations and the relative standard uncertainty of 0.95% is among the lowest of previously published data. - Highlights: • The half-life of 176 Lu was determined by ICP-OES, ICP-HRMS and LSC. • The LSC efficiency was determined with the CIEMAT/NIST method. • The half-life was found to be 3.640(35)×10 10 y

  1. Exploiting fine-grain parallelism in recursive LU factorization

    KAUST Repository

    Dongarra, Jack

    2012-01-01

    The LU factorization is an important numerical algorithm for solving system of linear equations. This paper proposes a novel approach for computing the LU factorization in parallel on multicore architectures. It improves the overall performance and also achieves the numerical quality of the standard LU factorization with partial pivoting. While the update of the trailing submatrix is computationally intensive and highly parallel, the inherently problematic portion of the LU factorization is the panel factorization due to its memory-bound characteristic and the atomicity of selecting the appropriate pivots. We remedy this in our new approach to LU factorization of (narrow and tall) panel submatrices. We use a parallel fine-grained recursive formulation of the factorization. It is based on conflict-free partitioning of the data and lock-less synchronization mechanisms. Our implementation lets the overall computation naturally flow with limited contention. Our recursive panel factorization provides the necessary performance increase for the inherently problematic portion of the LU factorization of square matrices. A large panel width results in larger Amdahl\\'s fraction as our experiments have revealed which is consistent with related efforts. The performance results of our implementation reveal superlinear speedup and far exceed what can be achieved with equivalent MKL and/or LAPACK routines. © 2012 The authors and IOS Press. All rights reserved.

  2. GREEN PLASTIC: A NEW PLASTIC FOR PACKAGING

    OpenAIRE

    Mr. Pankaj Kumar*, Sonia

    2016-01-01

    This paper gives a brief idea about a new type of plastic called as bio-plastic or green plastic. Plastic is used as a packaging material for various products, but this plastic is made up of non renewable raw materials. There are various disadvantages of using conventional plastic like littering, CO2 production, non-degradable in nature etc. To overcome these problems a new type of plastic is discovered called bio-plastic or green plastic. Bio-plastic is made from renewable resources and also...

  3. radiolabeling of DOTA-substance P with 177Lu and biodistribution of 177Lu-DOTA-substance P

    International Nuclear Information System (INIS)

    Liang Jixin; Li Hongyu; Xiang Xueqin; Luo Zhifu; Luo Hongyi; Hu Liansheng; Chen Yang; Zhuang Ling; Deng Xinrong

    2012-01-01

    The aim of this project is to evaluate the biodistribution of 177 Lu-DOTA-SP in normal mice and in PANC-1 tumor bearing nude mice and to pave the way for its potentially medical application. In this study, 177 Lu-DOTA-SP was successfully prepared with labeling yield of greater than 90% at optimized conditions and more than 98% of radiochemical purity after C18 Sep-Pak purification. 177 Lu-DOTA-SP showed good stability in saline and in 5% serum while it decomposed slowly in 10% serum. Biodistribution studies in normal mice showed high uptake of 177 Lu-DOTA-SP in the kidneys, indicating the excretion mainly by renal pathway. In addition, 177 Lu-DOTA-SP was washed out from the blood quickly. Bio- distribution of 177 Lu-DOTA-SP in PANC-1 tumor bearing mice showed higher uptake in pancreatic tumor than that in normal pancreas, indicating the presence of NK-1 receptors in PANC-1 pancreatic tumor. However, from SPECT image, no radioactivity accumulation was observed in PANC-1 tumor. Further evaluation is needed to confirm its potential application for radiotherapy of pancreatic cancers. (authors)

  4. Plastic condoms.

    Science.gov (United States)

    1968-01-01

    Only simple equipment, simple technology and low initial capital investment are needed in their manufacture. The condoms can be made by people who were previously unskilled or only semi-skilled workers. Plastic condoms differ from those made of latex rubber in that the nature of the plastic film allows unlimited shelf-life. Also, the plastic has a higher degree of lubricity than latex rubber; if there is a demand for extra lubrication in a particular market, this can be provided. Because the plastic is inert, these condoms need not be packaged in hermetically sealed containers. All these attributes make it possible to put these condoms on the distributors' shelves in developing countries competitively with rubber condoms. The shape of the plastic condom is based on that of the lamb caecum, which has long been used as luxury-type condom. The plastic condom is made from plastic film (ethylene ethyl acrilate) of 0.001 inch (0.0254 mm.) thickness. In addition, a rubber ring is provided and sealed into the base of the condom for retention during coitus. The advantage of the plastic condom design and the equipment on which it is made is that production can be carried out either in labour-intensive economy or with varying degrees of mechanization and automation. The uniform, finished condom if made using previously untrained workers. Training of workers can be done in a matter of hours on the two machines which are needed to produce and test the condoms. The plastic film is provided on a double wound roll, and condom blanks are prepared by means of a heat-sealing die on the stamping machine. The rubber rings are united to the condom blanks on an assembly machine, which consists of a mandrel and heat-sealing equipment to seal the rubber ring to the base of the condom. Built into the assembly machine is a simple air-testing apparatus that can detect the smallest pinhole flaw in a condom. The manufacturing process is completed by unravelling the condom from the assembly

  5. Adhesive activity of Lu glycoproteins is regulated by interaction with spectrin

    Energy Technology Data Exchange (ETDEWEB)

    An, Xiuli; Gauthier, Emilie; Zhang, Xihui; Guo, Xinhua; Anstee, David; Mohandas, Narla; Anne Chasis, Joel

    2008-03-18

    The Lutheran (Lu) and Lu(v13) blood group glycoproteins function as receptors for extracellular matrix laminins. Lu and Lu(v13) are linked to the erythrocyte cytoskeleton through a direct interaction with spectrin. However, neither the molecular basis of the interaction nor its functional consequences have previously been delineated. In the present study, we defined the binding motifs of Lu and Lu(v13) on spectrin and identified a functional role for this interaction. We found that the cytoplasmic domains of both Lu and Lu(v13) bound to repeat 4 of the spectrin chain. The interaction of full-length spectrin dimer to Lu and Lu(v13) was inhibited by repeat 4 of {alpha}-spectrin. Further, resealing of this repeat peptide into erythrocytes led to weakened Lu-cytoskeleton interaction as demonstrated by increased detergent extractability of Lu. Importantly, disruption of the Lu-spectrin linkage was accompanied by enhanced cell adhesion to laminin. We conclude that the interaction of the Lu cytoplasmic tail with the cytoskeleton regulates its adhesive receptor function.

  6. Magical Engineering Plastic

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Gwang Ung

    1988-01-15

    This book introduces engineering plastic about advantage of engineering plastic, plastic material from processing method, plastic shock, plastic until now, background of making of engineering plastic, wonderful engineering plastic science such as a high molecule and molecule, classification of high molecule, difference between metal and high molecule, heat and high molecule materials, and property of surface, engineering plastic of dream like from linseed oil to aramid, small dictionary of engineering plastic.

  7. Magical Engineering Plastic

    International Nuclear Information System (INIS)

    Kim, Gwang Ung

    1988-01-01

    This book introduces engineering plastic about advantage of engineering plastic, plastic material from processing method, plastic shock, plastic until now, background of making of engineering plastic, wonderful engineering plastic science such as a high molecule and molecule, classification of high molecule, difference between metal and high molecule, heat and high molecule materials, and property of surface, engineering plastic of dream like from linseed oil to aramid, small dictionary of engineering plastic.

  8. Mixed plastics recycling technology

    CERN Document Server

    Hegberg, Bruce

    1995-01-01

    Presents an overview of mixed plastics recycling technology. In addition, it characterizes mixed plastics wastes and describes collection methods, costs, and markets for reprocessed plastics products.

  9. Pervasive plastic

    Science.gov (United States)

    2018-05-01

    Human manipulation of hydrocarbons — as fuel and raw materials for modern society — has changed our world and the indelible imprint we will leave in the rock record. Plastics alone have permeated our lives and every corner of our planet.

  10. Plastic fish

    CERN Multimedia

    Antonella Del Rosso

    2015-01-01

    In terms of weight, the plastic pollution in the world’s oceans is estimated to be around 300,000 tonnes. This plastic comes from both land-based and ocean-based sources. A lecture at CERN by chemist Wolfgang Trettnak addressed this issue and highlighted the role of art in raising people’s awareness.   Artwork by Wolfgang Trettnak. Packaging materials, consumer goods (shoes, kids’ toys, etc.), leftovers from fishing and aquaculture activities… our oceans and beaches are full of plastic litter. Most of the debris from beaches is plastic bottles. “PET bottles have high durability and stability,” explains Wolfgang Trettnak, a chemist by education and artist from Austria, who gave a lecture on this topic organised by the Staff Association at CERN on 26 May. “PET degrades very slowly and the estimated lifetime of a bottle is 450 years.” In addition to the beach litter accumulated from human use, rivers bring several ki...

  11. Plastic deformation

    NARCIS (Netherlands)

    Sitter, de L.U.

    1937-01-01

    § 1. Plastic deformation of solid matter under high confining pressures has been insufficiently studied. Jeffreys 1) devotes a few paragraphs to deformation of solid matter as a preface to his chapter on the isostasy problem. He distinguishes two properties of solid matter with regard to its

  12. Comparison of Spectral and Scintillation Properties of LuAP:Ce and LuAP:Ce,Sc Single Crystals

    Science.gov (United States)

    Petrosyan, Ashot G.; Derdzyan, Marina; Ovanesyan, Karine; Shirinyan, Grigori; Lecoq, Paul; Auffray, Etiennette; Kronberger, Matthias; Frisch, Benjamin; Pedrini, Christian; Dujardin, Christophe

    2009-10-01

    Scintillation properties of LuAP:Ce and LuAP:Ce,Sc crystal series were studied under excitation by gamma-rays from a 137Cs source. Both series demonstrated comparable optical quality in terms of underlying absorption at 260 nm, slope of the optical edge and transmission in the range of emission. The light yield of LuAP:Ce crystals measured in 0.2 cm times 0.2 cm times 0.8 cm pixels increases linearly with the Ce concentration reaching at 0.58 at. % 6448 plusmn 322 ph/MeV and 9911 plusmn 496 ph/MeV in the long and in the short directions respectively (the light yield ratio is 65%) and shows no sign of light saturation. The energy resolution is found to depend, among other factors, on the uniformity of Ce concentration within the pixels and is improved to 7.1 plusmn 0.4% (I = 0.2 cm), 9.5 plusmn 0.5% (I = 0.8 cm). Intentional co-doping with Sc + ions was tested and resulted in increase of the Ce distribution coefficient to about 0.3. This enabled to increase the concentration of Ce in LuAP:Ce,Sc crystals up to 0.7 at. %, while conserving high optical quality. In contrast to LuAP:Ce, the light yield in LuAP:Ce,Sc crystals does not increase with Ce concentration, the photo peak being gradually suppressed. The involved mechanisms are discussed basing on measurements of the unit cell volumes, Ce concentration uniformity, x-ray rocking spectra, absorption spectra of pure and variously doped LuAP crystals, and emission spectra under different excitations.

  13. The Bad Berka dose protocol: comparative results of dosimetry in peptide receptor radionuclide therapy using (177)Lu-DOTATATE, (177)Lu-DOTANOC, and (177)Lu-DOTATOC.

    Science.gov (United States)

    Schuchardt, Christiane; Kulkarni, Harshad R; Prasad, Vikas; Zachert, Carolin; Müller, Dirk; Baum, Richard P

    2013-01-01

    The objective of this study is to analyze the in vivo behavior of the (177)Lu-labeled peptides DOTATATE, DOTANOC, and DOTATOC used for peptide receptor radionuclide therapy (PRRNT) of neuroendocrine tumors (NETs), by measuring organ and tumor kinetics and by performing dosimetric calculations. Two hundred fifty-three patients (group 1) with metastasized NET who underwent PRRNT were examined. Out of these, 185 patients received (177)Lu-DOTATATE, 9 were treated with (177)Lu-DOTANOC, and 59 with (177)Lu-DOTATOC. Additionally, 25 patients receiving, in consecutive PRRNT cycles, DOTATATE followed by DOTATOC (group 2) and 3 patients receiving DOTATATE and DOTANOC (group 3) were analyzed. Dosimetric calculations (according to MIRD scheme) were performed using OLINDA software. In group 1, DOTATOC exhibited the lowest and DOTANOC the highest uptake and therefore mean absorbed dose in normal organs (whole body, kidney, and spleen). In group 2, there was a significant difference between DOTATATE and DOTATOC concerning kinetics and normal organ doses. (177)Lu-DOTATOC had the lowest uptake/dose delivered to normal organs and highest tumor-to-kidney ratio. There were no significant differences between the three peptides concerning tumor kinetics and mean absorbed tumor dose. The study demonstrates a correlation between high affinity of DOTANOC in vitro and high uptake in normal organs/whole body in vivo, resulting in a higher whole-body dose. DOTATOC exhibited the lowest uptake and dose delivered to normal tissues and the best tumor-to-kidney ratio. Due to large interpatient variability, individual dosimetry should be performed for each therapy cycle.

  14. plastic waste recycling

    African Journals Online (AJOL)

    Dr Ahmed

    incinerators is increasing around the world. Discarded plastic products ... Agency (EPA) estimated that the amount of plastics throw away is. 50 % greater in the ... The waste plastics were identified using the Society of the Plastic. Industry (SPI) ...

  15. In vivo red cell destruction by anti-Lu6

    International Nuclear Information System (INIS)

    Issitt, P.D.; Valinsky, J.E.; Marsh, W.L.; DiNapoli, J.; Gutgsell, N.S.

    1990-01-01

    An example is presented of an IgG1, anti-Lu6, that reacted by indirect antiglobulin test and was capable of destroying antigen-positive red cells in vivo. Two methods for the measurement of red cell survival, 51 Cr labeling and flow cytometry, gave the same result: 20 percent of the test dose of Lu:6 red cells was destroyed in the first hour after injection and 80 percent in the first 24 hours. The clinical relevance of the antibody was correctly predicted by an in vitro monocyte monolayer assay. The finding that this example of anti-Lu6 was clinically significant should not be taken to mean that all antibodies directed against high-incidence Lutheran and Lutheran system-related antigens will behave similarly. When such antibodies are encountered, in vivo and/or in vitro studies to assess their clinical significance are necessary before rare blood is used for transfusion

  16. Surface magnetic phase transitions in Dy/Lu superlattices

    International Nuclear Information System (INIS)

    Goff, J.P.; Sarthour, R.S.; Micheletti, C.; Langridge, S.; Wilkins, C.J.T.; Ward, R.C.C.; Wells, M.R.

    1999-01-01

    Dy/Lu superlattices comprising ferromagnetic Dy blocks coupled antiferromagnetically across the Lu blocks may be modelled as a chain of XY spins with antiferromagnetic exchange and six-fold anisotropy. We have calculated the stable magnetic phases for the cases of large anisotropy and a field applied along an easy direction. For an infinite chain an intermediate phase (1, 5,...) is predicted, where the notation gives the angle between the moment and the applied field in units of π/3. Furthermore, the effects of surface reconstruction are determined for finite chains. A [Dy 20 Lu 12 ] 20 superlattice has been studied using bulk magnetization and polarized neutron reflectivity. The (1, 5,...) phase has been identified and the results provide direct evidence in support of the theoretical predictions. Dipolar forces are shown to account for the magnitude of the observed exchange coupling. (Copyright (c) 1999 Elsevier Science B.V., Amsterdam. All rights reserved.)

  17. Proton Radioactivity Measurements at HRIBF: Ho, Lu, and Tm Isotopes

    International Nuclear Information System (INIS)

    Akovali, Y.; Batchelder, J.C.; Bingham, C.R.; Davinson, T.; Ginter, T.N.; Gross, C.J.; Grzywacz, R.; Hamilton, J.H.; Janas, Z.; Karny, M.; Kim, S.H.; MacDonald, B.D.; Mas, J.F.; McConnell, J.W.; Piechaczek, A.; Ressler, J.J.; Rykaczewski, K.; Slinger, R.C.; Szerypo, J.; Toth, K.S.; Weintraub, W.; Woods, P.J.; Yu, C.-H.; Zganjar, E.F.

    1998-01-01

    Two new isotopes, 145 Tm and 140 Ho and three isomers in previously known isotopes, 141m Ho, 150m Lu and 151m Lu have been discovered and studied via their decay by proton emission. These proton emitters were produced at the Holifield Radioactive Ion Beam Facility (HRIBF) by heavy-ion fusion-evaporation reactions, separated in A/Q with a recoil mass spectrometer (RMS), and detected in a double-sided silicon strip detector (DSSD). The decay energy and half-life was measured for each new emitter. An analysis in terms of a spherical shell model is applied to the Tm and Lu nuclei, but Ho is considerably deformed and requires a collective model interpretation

  18. Evidence for inelastic neutron acceleration by the 177Lu isomer

    International Nuclear Information System (INIS)

    Roig, O.; Belier, G.; Meot, V.; Daugas, J.-M.; Abt, D.; Aupiais, J.; Jutier, Ch.; Petit, G. Le; Letourneau, A.; Marie, F.; Veyssiere, Ch.

    2006-01-01

    The neutron burnup cross section σ burnup m on the long-lived metastable state of 177 Lu has been measured from a specially designed isomeric target. The Maxwellian averaged cross section obtained for this reaction on 177 Lu m (J π =23/2 - ) is σ burnup m =626±45 b at the reactor temperature T=323 K. The difference between the burnup cross section and the previously measured capture cross section σ n,γ clearly shows a possible existence of 177 Lu m deexcitation via (n,n ' ) inelastic neutron acceleration channels. The results are interpreted in terms of a statistical approach using parameters from a deformed optical potential calculation

  19. Preparation of 177Lu-DTPA-BIS-BIOTIN and biodistribution evaluation in normal mice

    International Nuclear Information System (INIS)

    Deng Xinrong; Luo Zhifu; Du Jin

    2010-01-01

    The labeling method for 177 Lu-DTPA-BIS-BIOTIN was established, and the biodistribution of 177 Lu-DTPA-BIS-BIOTIN in normal mice was carried out as well. Under the optimal experimental condition (DTPA-BIS-BIOTIN 25 μg, pH=4.5 reacting at 80 degree C for 20 min), the labeling yield of 177 Lu-DTPA-BIS-BIOTIN is more than 99.0%. 177 Lu-DTPA-BIS-BIOTIN shows pretty good in vitro stability. The biodistribution of 177 Lu-DTPA-BIS-BIOTIN in normal mice shows a rapid blood clearance. The uptake of 177 Lu-DTPA-BIS-BIOTIN is mainly accumulated in liver, spleen and kidney. 177 Lu-DTPA-BIS-BIOTIN is excreted by kidney. The results provide the basis for further study on 177 Lu-DTPA-BIS-BIOTIN used in pretargeted radioimage and radiotherapy of cancer. (authors)

  20. Revisiting the level scheme of the proton emitter 151Lu

    International Nuclear Information System (INIS)

    Wang, F.; Sun, B.H.; Liu, Z.; Scholey, C.; Eeckhaudt, S.; Grahn, T.; Greenlees, P.T.; Jones, P.; Julin, R.; Juutinen, S.; Kettelhut, S.; Leino, M.; Nyman, M.; Rahkila, P.; Saren, J.; Sorri, J.; Uusitalo, J.; Ashley, S.F.; Cullen, I.J.; Garnsworthy, A.B.; Gelletly, W.; Jones, G.A.; Pietri, S.; Podolyak, Z.; Steer, S.; Thompson, N.J.; Walker, P.M.; Williams, S.; Bianco, L.; Darby, I.G.; Joss, D.T.; Page, R.D.; Pakarinen, J.; Rigby, S.; Cullen, D.M.; Khan, S.; Kishada, A.; Gomez-Hornillos, M.B.; Simpson, J.; Jenkins, D.G.; Niikura, M.; Seweryniak, D.; Shizuma, Toshiyuki

    2015-01-01

    An experiment aiming to search for new isomers in the region of proton emitter 151 Lu was performed at the Accelerator Laboratory of the University of Jyväskylä (JYFL), by combining the high resolution γ-ray array JUROGAM, gas-filled RITU separator and GREAT detectors with the triggerless total data readout acquisition (TDR) system. In this proceeding, we revisit the level scheme of 151 Lu by using the proton-tagging technique. A level scheme consistent with the latest experimental results is obtained, and 3 additional levels are identified at high excitation energies. (author)

  1. Dosimetric Studies in Normal Mice of 177Lu-DOTA-SP and 177Lu-DOTA-His2-MG

    International Nuclear Information System (INIS)

    Puerta Yepes, N.; Rojo, A.M.; Lopez Bularte, A.C.; Nevares, N.; Zapata, M.; Perez, J.H.; Crudo, J.

    2010-01-01

    DOTA-Substance-P (SP) and DOTA-minigastrin (His2-MG) labeled with 177 Lu could be used in peptide receptor radionuclide therapy (PRRT) for treatment of various tumour species. Biodistribution studies of both radiopharmaceuticals in normal mice were performed at different times. Absorbed doses in mouse organs were estimated and extrapolated to humans. Dosimetric calculations showed that kidneys received the highest dose, for both radiopharmaceuticals. The Maximum Tolerated Activity (MTA) of 177 Lu-DOTA-SP that can be administered without kidney toxicity are 414 and 422 MBq/kg for the standard adult man and woman, respectively. In the same way, the MTA of 177 Lu-DOTA-His2-MG are 488 and 518 MBq/kg for the standard adult man and woman, respectively. (authors)

  2. Measurement of the cross sections for the 175Lu(n,2n)174m,gLu reaction

    International Nuclear Information System (INIS)

    Yu Weixiang; Zhao Wenrong; Lu Hanlin; Han Xiaogang

    1998-01-01

    The 175 Lu(n,2n) 174m,g Lu reaction is an important indicator. There are 10 sets of measured data since 1960 (total 58 experimental values). Most of the data are finished at 14 MeV with 20%∼30% discrepancy. So the authors measured the cross section by activation method in neutron energies of 14 MeV and 10∼12 MeV. The measurement is carried out at the Cockcroft-Walton and HI-13 Tandem accelerator of CIAE

  3. O- centers in LuAG:Ce,Mg ceramics

    Czech Academy of Sciences Publication Activity Database

    Hu, C.; Liu, S.; Fasoli, M.; Vedda, A.; Nikl, Martin; Feng, X. Q.; Pan, Y.B.

    2015-01-01

    Roč. 9, č. 4 (2015), s. 245-249 ISSN 1862-6254 R&D Projects: GA ČR GAP204/12/0805 Institutional support: RVO:68378271 Keywords : scintillator * hole center * EPR * LuAG * Ce 3+ Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.578, year: 2015

  4. Exploiting fine-grain parallelism in recursive LU factorization

    KAUST Repository

    Dongarra, Jack; Faverge, Mathieu; Ltaief, Hatem; Luszczek, Piotr R.

    2012-01-01

    is the panel factorization due to its memory-bound characteristic and the atomicity of selecting the appropriate pivots. We remedy this in our new approach to LU factorization of (narrow and tall) panel submatrices. We use a parallel fine-grained recursive

  5. Study of the production of {sup 177}Lu through {sup 176}Yb (n, {gamma}) {sup 177}Yb {yields} {sup 177}Lu nuclear reaction

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Giovana Pasqualini da; Osso Junior, Joao Alberto [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)]. E-mail: gpsilva@ipen.br; jaosso@ipen.br

    2007-07-01

    The beta minus emitter {sup 177}Lu is a promising therapeutic radioisotope for the curative treatment of cancer using labelled proteins. It has a half - life of T{sub 1/2} = 6.71 day and maximum and average {beta}{sup -} energies of 421 and 133 keV, resulting in a short range of radiation in tissue. The decay is accompanied by the emission of low energy {gamma}-radiation with 208.3 keV (11%) and 113 keV (6.4%) suitable for simultaneous imaging, {sup 177}Lu can be produced by two different routes, namely, by irradiation of natural Lu{sub 2}O{sub 3} target ({sup 176}Lu, 2.6%) or enriched (in {sup 176}Lu) Lu{sub 2}O{sub 3} target, as also by irradiation of Yb target (Yb{sub 2}O{sub 3}) followed by radiochemical separation of {sup 177}Lu from Yb isotopes. The objective of this work is to study the production of {sup 177}Lu through the indirect {sup 176}Yb(n,{gamma}){sup 177}Yb {yields} {sup 177}Lu nuclear reaction. The results of the production yield of {sup 177}Lu will be shown and compared with the direct reaction. The method of choice for the chemical separation between Lu and Yb was the ion exchange, using an cation exchange resin in Cl{sup -} form and {alpha}-HIBA as eluent. Preliminary results showed a good separation of {sup 177}Lu from Yb{sub 2}O{sub 3} indirect targets. (author)

  6. 177Lu-DOTA-Bevacizumab: Radioimmunotherapy Agent for Melanoma.

    Science.gov (United States)

    Camacho, Ximena; Calzada, Victoria; Fernandez, Marcelo; Alonso, Omar; Chammas, Roger; Riva, Eloisa; Gambini, Juan Pablo; Cabral, Pablo

    2017-01-01

    Vascular endothelial growth factor (VEGF) is one of the classic factors to tumor-induced angiogenesis in several types, including melanoma. Bevacizumab is a humanized monoclonal antibody directed against VEGF. To radiolabel Bevacizumab with 177-Lutetium as a potential radioimmunotherapy agent for melanoma. Bevacizumab was derivatized with DOTA-NHS-ester at 4 ºC for 18 h. DOTABevacizumab was radiolabeled with 177LuCl3 (15 MBq/mg) at 37 ºC for 1 h. The studies were performed in healthy and B16F1 tumor-bearing C57BL/6J mice at 24 and 48 h (n = 5). Scinthigraphic imaging studies were performed at 24 h to determine the radiochemical stability, targeting specificity and pharmacokinetics of the 177Lutetium-labeled antibody. DOTA-Bevacizumab was efficiently labeled with 177LuCl3 at 37 °C. The in-vitro stability of labeled product was optimal over 72 h. In-vivo biodistribution studies showed a high liver and tumor uptake of 177Lu-DOTA-Bevacizumab, with tumor-to-muscle ratios of 11.58 and 6.37 at 24 and 48 h p.i. Scintigraphic imaging of melanoma tumor-bearing C57BL/6J mice showed liver and a high tumor selective uptake of 177Lu-DOTA-Bevacizumab at 24 h. Our results support the potential role of 177Lu-DOTA-Bevacizumab as a novel radioimmunotherapy agent for melanoma. We hope that these novel molecular imaging agents will open the path to new diagnostic and therapeutic strategies for Melanoma disease. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  7. First evidence for triaxial superdeformation in sup 1 sup 6 sup 1 Lu and sup 1 sup 6 sup 2 Lu

    CERN Document Server

    Bringel, P; Domscheit, J; Neusser, A; Schoenwasser, G; Singh, A K; Amro, H; Axiotis, M; Kröll, T; Napoli, D R; Bazzacco, D; Lunardi, S; Ur, C; Bhattacharya, S; Bhowmik, R; Hagemann, G B; Jensen, D R; Pancholi, S C; Petrache, C M

    2003-01-01

    High-spin states in sup 1 sup 6 sup 1 Lu and sup 1 sup 6 sup 2 Lu have been investigated using the GASP gamma-ray spectrometer array. Excited states in these nuclei have been populated through the sup 1 sup 0 sup 0 Mo( sup 6 sup 5 Cu, xn) reaction at a beam energy of 260 MeV. Four presumably triaxial superdeformed bands, three in sup 1 sup 6 sup 2 Lu and one in sup 1 sup 6 sup 1 Lu, have been observed. This is the first evidence for triaxial superdeformation in the two isotopes. (orig.)

  8. LuFLA1PRO and LuBGAL1PRO promote gene expression in the phloem fibres of flax (Linum usitatissimum).

    Science.gov (United States)

    Hobson, Neil; Deyholos, Michael K

    2013-04-01

    Cell type-specific promoters were identified that drive gene expression in an industrially important product. To identify flax (Linum usitatissimum) gene promoters, we analyzed the genomic regions upstream of a fasciclin-like arabinogalactan protein (LuFLA1) and a beta-galactosidase (LuBGAL1). Both of these genes encode transcripts that have been found to be highly enriched in tissues bearing phloem fibres. Using a beta-glucuronidase (GUS) reporter construct, we found that a 908-bp genomic sequence upstream of LuFLA1 (LuFLA1PRO) directed GUS expression with high specificity to phloem fibres undergoing secondary cell wall development. The DNA sequence upstream of LuBGAL1 (LuBGAL1PRO) likewise produced GUS staining in phloem fibres with developing secondary walls, as well as in tissues of developing flowers and seed bolls. These data provide further evidence of a specific role for LuFLA1 in phloem fibre development, and demonstrate the utility of LuFLA1PRO and LuBGAL1PRO as tools for biotechnology and further investigations of phloem fibre development.

  9. Plastic scintillator

    International Nuclear Information System (INIS)

    Andreeshchev, E.A.; Kilin, S.F.; Kavyrzina, K.A.

    1978-01-01

    A plastic scintillator for ionizing radiation detectors with high time resolution is suggested. To decrease the scintillation pulse width and to maintain a high light yield, the 4 1 , 4 5 -dibromo-2 1 , 2 5 , 5 1 , 5 5 -tetramethyl-n-quinquiphenyl (Br 2 Me 4 Ph) in combination with n-terphenyl (Ph 3 ) or 2, 5-diphenyloxadiazol-1, 3, 4 (PPD) is used as a luminescent addition. Taking into consideration the results of a special study, it is shown, that the following ratio of ingradients is the optimum one: 3-4 mass% Ph 3 or 4-7 mas% PPD + 2-5 mass% Br 2 Me 4 Ph + + polymeric base. The suggested scintillator on the basis of polystyrene has the light yield of 0.23-0.26 arbitrary units and the scintillation pulse duration at half-height is 0.74-0.84 ns

  10. Toxicological Threats of Plastic

    Science.gov (United States)

    Plastics pose both physical (e.g., entanglement, gastrointestinal blockage, reef destruction) and chemical threats (e.g., bioaccumulation of the chemical ingredients of plastic or toxic chemicals sorbed to plastics) to wildlife and the marine ecosystem.

  11. The Romanian Căluş: Symbol of National Identity

    Directory of Open Access Journals (Sweden)

    Camelia Firică

    2011-05-01

    Full Text Available Of all Romanian dances with ritual functions the most archaic and dynamic is the căluş, a custom of great complexity in its functionality and manifestation, in which dance prevails. Over the course of time, the dance aroused the admiration and interest of many scholars due to the ancient ritual elements it contains, as well as for its spectacular virtuosity and the beauty of the performance and music. The purpose of this study is to reveal the meanings and functions of the căluş, primarily at the social level, in its natural environment – the traditional Romanian village – and to make an analysis of the key moments, the logical order of the dance sequences, gestures and ritual acts, the importance of its props and of group composition and organisation.

  12. The Romanian Căluş: Symbol of National Identity

    Directory of Open Access Journals (Sweden)

    Camelia Firică

    2010-12-01

    Full Text Available Of all Romanian dances with ritual functions the most archaic and dynamic is the căluş, a custom of great complexity in its functionality and manifestation, in which dance prevails. Over the course of time, the dance aroused the admiration and interest of many scholars due to the ancient ritual elements it contains, as well as for its spectacular virtuosity and the beauty of the performance and music. The purpose of this study is to reveal the meanings and functions of the căluş, primarily at the social level, in its natural environment – the traditional Romanian village – and to make an analysis of the key moments, the logical order of the dance sequences, gestures and ritual acts, the importance of its props and of group composition and organisation.

  13. Electronic, ductile, phase transition and mechanical properties of Lu-monopnictides under high pressures.

    Science.gov (United States)

    Gupta, Dinesh C; Bhat, Idris Hamid

    2013-12-01

    The structural, elastic and electronic properties of lutatium-pnictides (LuN, LuP, LuAs, LuSb, and LuBi) were analyzed by using full-potential linearized augmented plane wave within generalized gradient approximation in the stable rock-salt structure (B1 phase) with space group Fm-3m and high-pressure CsCl structure (B2 phase) with space group Pm-3m. Hubbard-U and spin-orbit coupling were included to predict correctly the semiconducting band gap of LuN. Under compression, these materials undergo first-order structural transitions from B1 to B2 phases at 241, 98, 56.82, 25.2 and 32.3 GPa, respectively. The computed elastic properties show that LuBi is ductile by nature. The electronic structure calculations show that LuN is semiconductor at ambient conditions with an indirect band gap of 1.55 eV while other Lu-pnictides are metallic. It was observed that LuN shows metallization at high pressures. The structural properties, viz, equilibrium lattice constant, bulk modulus and its pressure derivative, transition pressure, equation of state, volume collapse, band gap and elastic moduli, show good agreement with available data.

  14. K-electron capture probability in 171Lu

    International Nuclear Information System (INIS)

    Mishra, N.R.; Vara Prasad, N.V.S.; Chandrasekhara Rao, M.V.S.; Satyanarayana, G.; Sastry, D.L.; Chintalapudi, S.N.

    1999-01-01

    The K-electron capture probability in the decay of 171 Lu to the 835.06 keV level of the daughter nucleus 171 Yb is measured to be 0.822 ± 0.027 involving two transitions, in agreement with the theoretical value 0.833. The experimental value is seen to be consistent with the mass prediction of the relationship due to Wapstra and Bos. (author)

  15. Development of LuAG-based scintillator crystals - A review

    Czech Academy of Sciences Publication Activity Database

    Nikl, Martin; Yoshikawa, A.; Kamada, K.; Nejezchleb, K.; Stanek, C.R.; Mareš, Jiří A.; Blazek, K.

    2013-01-01

    Roč. 59, č. 2 (2013), s. 47-72 ISSN 0960-8974 R&D Projects: GA ČR GAP204/12/0805; GA AV ČR KAN300100802 Grant - others:GA AV(CZ) M100100910 Institutional support: RVO:68378271 Keywords : garnet * scintillator * Lu 3 Al 5 O 12 * Ce 3+ * Pr 3+ * Sc 3+ * Yb 3+ Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.476, year: 2013

  16. Development of 177Lu-phytate Complex for Radiosynovectomy

    Directory of Open Access Journals (Sweden)

    Hassan Yousefnia

    2013-05-01

    Full Text Available Objective(s: In this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. Materials and Methods: Lu-177 of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu2O3 sample with thermal neutron flux of 4 × 1013 n.cm-2.s-1. The product was converted into chloride form which was further used for labeling of 177Lu-phytate complex and checked using ITLC (MeOH: H2O: acetic acid, 4: 4: 2, as mobile phase. The complex stability and viscosity were checked in the final solution up to seven days. The prepared complex solution (100 µCi/100 µl was injected intra-articularly to male rat knee joint. Leakage of radioactivity from injection site and its distribution in organs were investigated up to seven days. Results: The complex was successfully prepared with high radiochemical purity (>99.9 %. Approximately, the whole injected dose has remained in injection site seven days after injection. Conclusion: The complex was proved to be a feasible agent for cavital radiotherapy in oncology and rheumatology

  17. Incorporation of Pr into LuAG ceramics

    Science.gov (United States)

    Marchewka, M. R.; Chapman, M. G.; Qian, H.; Jacobsohn, L. G.

    2017-06-01

    An investigation of the effects of Pr in (Lu1-xPrx)3Al5O12 (LuAG:Pr) ceramics was carried out by means of x-ray diffraction (XRD), energy dispersive x-ray spectroscopy (EDX), and attenuated total reflection Fourier transform infrared spectroscopy (ATR FTIR) measurements coupled with luminescence measurements. It was found that the Pr concentration that maximizes luminescence emission depends on the thermal processing conditions. While the calcined LuAG:Pr powder showed maximum luminescence emission for Pr concentrations between 0.18 and 0.33 at.%, maximum emission of ceramic bodies sintered at 1500 °C for 20 h was obtained with Pr concentrations between 0.018 and 0.18 at.%. Further, for short sintering times up to about 3 h, luminescence emission intensity is maximum for Pr concentrations around 0.33 at.%. Longer sintering times lead to the formation of PrAlO3 as a secondary phase, concomitant with a reduction of the intensity of luminescence emission.

  18. Encapsulation of a radiolabeled cluster inside a fullerene cage, (177)Lu(x)Lu((3-x))N@C(80): an interleukin-13-conjugated radiolabeled metallofullerene platform.

    Science.gov (United States)

    Shultz, Michael D; Duchamp, James C; Wilson, John D; Shu, Chun-Ying; Ge, Jiechao; Zhang, Jianyuan; Gibson, Harry W; Fillmore, Helen L; Hirsch, Jerry I; Dorn, Harry C; Fatouros, Panos P

    2010-04-14

    In this communication, we describe the successful encapsulation of (177)Lu into the endohedral metallofullerene (177)Lu(x)Lu(3-x)N@C(80) (x = 1-3) starting with (177)LuCl(3) in a modified quartz Kraschmer-Huffman electric generator. We demonstrate that the (177)Lu (beta-emitter) in this fullerene cage is not significantly released for a period of up to at least one-half-life (6.7 days). We also demonstrate that this agent can be conjugated with an interleukin-13 peptide that is designed to target an overexpressed receptor in glioblastoma multiforme tumors. This nanoparticle delivery platform provides flexibility for a wide range of radiotherapeutic and radiodiagnostic multimodal applications.

  19. Primary standardization of a {sup 177}Lu solution; Padronizacao primaria de uma solucao de {sup 177}Lu

    Energy Technology Data Exchange (ETDEWEB)

    Iwahara, Akira; Silva, Carlos Jose da; Tauhata, Luiz; Oliveira, Estela Maria de, E-mail: iwahara@ird.gov.b, E-mail: carlos@ird.gov.b, E-mail: tauhata@ird.gov.b, E-mail: estela@ird.gov.b [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil); Rezende, Eduarda Alexandre, E-mail: eduarda@ird.gov.b [Centro Federal de Educacao Tecnologica de Quimica (CEFET), Nilopolis, RJ (Brazil)

    2009-07-01

    For the purpose to make available reliable standards of {sup 177}Lu to the users and producers, a radionuclide solution was standardized using the primary methods of coincidence 4{pi}{beta}(PC)-{gamma}(NaI(Tl)) and of 4{pi}{beta}(LS)-{gamma}(NaI(Tl)). The results presented a convergence in the range of evaluated uncertainties. The standard uncertainties were of the 0.50 and 0.74% for the anticoincidence and coincidence respectively

  20. Recycling of Plastic

    DEFF Research Database (Denmark)

    Christensen, Thomas Højlund; Fruergaard, Thilde

    2011-01-01

    Plastic is produced from fossil oil. Plastic is used for many different products. Some plastic products like, for example, wrapping foil, bags and disposable containers for food and beverage have very short lifetimes and thus constitute a major fraction of most waste. Other plastic products like...

  1. High spin K isomeric target of {sup 177m}Lu

    Energy Technology Data Exchange (ETDEWEB)

    Roig, O. E-mail: olivier.roig@cea.fr; Belier, G.; Daugas, J.-M.; Delbourgo, P.; Maunoury, L.; Meot, V.; Morichon, E.; Sauvestre, J.-E.; Aupiais, J.; Boulin, Y.; Fioni, G.; Letourneau, A.; Marie, F.; Ridikas, D

    2004-03-21

    The techniques used to produce a {sup 177m}Lu (J{sup {pi}}=23/2{sup -},T{sub 1/2}=160.4 days) target are described in this paper. Firstly, an isotopic separation of an enriched lutetium sample was used to reach a purity of {sup 176}Lu close to 99.993%. Afterwards, the high neutron flux of the Grenoble Institut Laue-Langevin reactor was used to produce the {sup 177m}Lu isomer by the {sup 176}Lu(n,{gamma}) reaction. Finally, a chemical separation was performed to extract 10{sup 13} nuclei of {sup 177m}Lu. Thanks to this experiment, we have been able to estimate the destruction cross-section of the {sup 177m}Lu.

  2. Comparison of tumour and whole body absorbed doses of 177-Lu-DOTA-TATE and Lu-177-DOTA-NOC treatment in the same patient group

    International Nuclear Information System (INIS)

    Yeyin, N.; Kabasakal, L.; Akyel, R.; Demir, M.; Kanmaz, B.; Ocak, M.; Toklu, T.; Selcuk, N.

    2015-01-01

    Full text of publication follows. Peptide Receptor Radionuclide Therapy (PRRT) with Lu-177 labelled peptides in patients with neuroendocrine tumours (NETs) aroused great interest. An estimation of actual radiation doses to tumours is very important for therapy planning. There are several radiolabelled peptides, which can be used for PRRT with different biological behaviour. Aim: the aim of the study was to compare the tumour and normal organ absorbed doses in patients who have received Lu-177-DOTA-TATE and Lu-177 DOTA-NOC. Materials and methods: study was composed of 20 patients (M/F: 10/10, mean age: 51.5 ± 14.9) with histologically proven inoperable NETs. All patients received Lu-177-DOTA-NOC treatment 6 to 12 weeks after last Lu-177-DOTA-TATE treatment. Dosimetric calculations were performed using MIRD scheme and lesion doses were calculated using post therapy whole body images obtained at 4, 20, 44, and 68 hours after injection. Tumour volumes were determined from CT images. Thirteen blood samples beginning from time zero to 4 days after injection were obtained for bone marrow and whole body dosimetry. Results: There were 53 lesions in Lu-177-DOTA-TATE post-therapy whole body images and 49 lesions in Lu-177 DOTA-NOC post therapy images. Lesions were selected according to lesion delineation and superimposed lesions were excluded. Mean lesion absorbed dose is calculated to be 47.4 ± 53.4 and 42.9 ± 52.8 Gy per 370 MBq for Lu-177-DOTA-TATE and DOTA-NOC respectively (p>0.5). There were significantly higher absorbed doses for kidney and bone marrow after Lu-177-DOTA-NOC treatment as compared to Lu-177-DOTA-TATE treatment, which were 6.9 ± 2.7 vs 3.9 ± 1.7 (p<0.05) and 0.12 ± 0.0 vs 0.10 ± 0.0 (p<0.05) Gy, respectively. There was not any difference in plasma elimination times between two tracers. On the other hand the whole body absorbed dose was significantly higher after Lu-177-DOTA-NOC treatment, which was 0.24 ± 0.07 vs 0.20 ± 0.06 Gy (p<0

  3. LuIII parvovirus selectively and efficiently targets, replicates in, and kills human glioma cells.

    Science.gov (United States)

    Paglino, Justin C; Ozduman, Koray; van den Pol, Anthony N

    2012-07-01

    Because productive infection by parvoviruses requires cell division and is enhanced by oncogenic transformation, some parvoviruses may have potential utility in killing cancer cells. To identify the parvovirus(es) with the optimal oncolytic effect against human glioblastomas, we screened 12 parvoviruses at a high multiplicity of infection (MOI). MVMi, MVMc, MVM-G17, tumor virus X (TVX), canine parvovirus (CPV), porcine parvovirus (PPV), rat parvovirus 1A (RPV1A), and H-3 were relatively ineffective. The four viruses with the greatest oncolytic activity, LuIII, H-1, MVMp, and MVM-G52, were tested for the ability, at a low MOI, to progressively infect the culture over time, causing cell death at a rate higher than that of cell proliferation. LuIII alone was effective in all five human glioblastomas tested. H-1 progressively infected only two of five; MVMp and MVM-G52 were ineffective in all five. To investigate the underlying mechanism of LuIII's phenotype, we used recombinant parvoviruses with the LuIII capsid replacing the MVMp capsid or with molecular alteration of the P4 promoter. The LuIII capsid enhanced efficient replication and oncolysis in MO59J gliomas cells; other gliomas tested required the entire LuIII genome to exhibit enhanced infection. LuIII selectively infected glioma cells over normal glial cells in vitro. In mouse models, human glioblastoma xenografts were selectively infected by LuIII when administered intratumorally; LuIII reduced tumor growth by 75%. LuIII also had the capacity to selectively infect subcutaneous or intracranial gliomas after intravenous inoculation. Intravenous or intracranial LuIII caused no adverse effects. Intracranial LuIII caused no infection of mature mouse neurons or glia in vivo but showed a modest infection of developing neurons.

  4. Crystal growth, spectroscopic and laser properties of Tm:LuAG crystal

    Science.gov (United States)

    Xu, X. D.; Wang, X. D.; Lin, Z. F.; Cheng, Y.; Li, D. Z.; Cheng, S. S.; Wu, F.; Zhao, Z. W.; Gao, C. Q.; Gao, M. W.; Xu, J.

    2009-11-01

    Tm:Lu3Al5O12 (Tm:LuAG) crystal was grown by the Czochralski method. The segregation coefficient was measured by Inductively Coupled Plasma Atomic Emission Spectrometer. The cell parameters were analyzed with X-ray powder diffraction experiments. The absorption and fluorescence spectra of Tm:LuAG crystal at room temperature were investigated. With a 20 W fiber-coupled diode laser as pump source, the continuous-wave (CW) laser action of Tm:LuAG crystal was demonstrated. The maximum output power at 2020 nm was obtained to be 3.04 W, and the slope efficiency was 25.3%.

  5. Synthesis of DOTMP and biodistribution and imaging study of 177-Lu-DOTMP

    International Nuclear Information System (INIS)

    Deng Xinrong; Luo Zhifu; Xiang Xueqin; Li Fenglin; Fan Caiyun; Liu Zihua; Ye Zhaoyun; Li Hongyu; Chen Yang; Zhuang Ling

    2012-01-01

    Cyclen (1, 4, 7, 10-tetraazacyclododecane) and H 3 PO 3 was used to synthesis DOTMP (1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-Tetraamino methylenephosphonate). 177 Lu was produced by irradiating enriched lutetium oxide ( 176 Lu 2 O 3 ) with thermal neutron flux of 2' × 10 13 n/cm 2 /S in swimming pool reactor (SPR) for 10 days. And then DOTMP was labelled by 177 Lu. The biodistribution of 177 Lu-DOTMP in model mice bearing S180 sarcoma and SPECT imaging in Japanese white rabbit were also carried out. The results showed that the total activity of 177 LuCl 3 solution obtained was 9.19 × 10 5 MBq after corresponding chemical process. According to the optimal condition of the labeling experiment, the labelling efficiency of 177 Lu-DOTMP was 99.4%. The results of biodistribution study indicated that 177 Lu-DOTMP eliminated rapidly from blood and was delivered to target bone. The radioactivity uptake was mainly in bone and less in other viscera. The results of SPECT imaging showed that the radioactivity was accumulated in bladder. 177 Lu-DOTMP was mainly excreted by kidney. The uptake of the activity in the skeleton was observed within 22 h postinjection and it became quite significant at 46 h post injection. It indicated that 177 Lu-DOTMP has good bone targeting and is worthy of further research. (authors)

  6. Evaluation of SuperLU on multicore architectures

    International Nuclear Information System (INIS)

    Li, X S

    2008-01-01

    The Chip Multiprocessor (CMP) will be the basic building block for computer systems ranging from laptops to supercomputers. New software developments at all levels are needed to fully utilize these systems. In this work, we evaluate performance of different high-performance sparse LU factorization and triangular solution algorithms on several representative multicore machines. We included both Pthreads and MPI implementations in this study and found that the Pthreads implementation consistently delivers good performance and that a left-looking algorithm is usually superior

  7. Triaxiality and the wobbling mode In 167Lu

    International Nuclear Information System (INIS)

    Amro, H.; Ma, W.C.; Winger, J.A.; Li, Y.; Thompson, J.; Hagemann, G.; Herskind, B.; Sletten, G.; Wilson, J.N.; Jensen, D.R.; Fallon, P.; Ward, D.; Diamond, R.M.; Goergen, A.; Machiavelli, A.; Huebel, H.; Domscheit, J.; Wiedenhoewer, I.

    2002-01-01

    High spin states in 167Lu nucleus were populated through the 123Sb(48Ca,xn) reaction at 203 MeV. Five presumably triaxial superdeformed (TSD) bands have been found. The electromagnetic properties of several connecting transitions between the yrast (TSD1) and the excited (TSD2) bands have been established. Evidence for the assignment of TSD2 band as a wobbling mode built on the yrast TSD band is presented. These bands coexist with bands built on quasiparticle excitations in normal deformed (ND) minimum for which new data are also presented

  8. Optical and scintillating properties of Ce:Li(Y,Lu)F4 single crystals

    International Nuclear Information System (INIS)

    Yokota, Yuui; Kurosawa, Shunsuke; Chani, Valery; Kamada, Kei; Yoshikawa, Akira

    2014-01-01

    We have investigated the optical and scintillating properties of Lu co-doped Ce:LiYF 4 single crystals with various Lu content. In the transmittance and absorption spectra, the absorption peaks at 243 nm get systematically red shifted in contrast to the peaks at 197 and 200 nm which get blue shifted with the increase in Lu content. At the same time, emission peaks at 306 nm and 200 nm under 295 nm excitation also get red shifted. The decay time of Ce:Li(Y,Lu)F 4 crystals under 295 nm excitation is found to be faster than that of Ce:LiYF 4 and Ce:LiLuF 4 crystals. The alpha-peak positions in the pulse-height spectra and decay times of crystals under alpha-ray irradiation are found to vary with the Lu content. - Highlights: • Optical and scintillation properties of Ce:Li(Y 1-x Lu x )F 4 crystals were inspected. • Increase of Lu content resulted change of the position of four absorption peaks. • Admixing of Y and Lu decreased the light yield and increased the decay time. • The Ce:LiLuF 4 crystal indicated the largest light yield in the pulse-height spectra. • Li[(Y 0.8 Lu 0.2 ) 0.98 Ce 0.02 ]F 4 indicated larger light yield than Ce:LiYF 4 crystal

  9. Comparison of the luminescent properties of Lu3Al5O12:Pr crystals and films under synchrotron radiation excitation

    International Nuclear Information System (INIS)

    Zorenko, Yu.; Gorbenko, V.; Zorenko, T.; Voznyak, T.; Nizankovskiy, S.

    2016-01-01

    The work is dedicated to comparative investigation of the luminescent properties of Lu 3 Al 5 O 12 :Pr(LuAG:Pr) single crystals and single crystalline films using excitation by synchrotron radiation with an energy of 3.7–25 eV in the exciton range of LuAG host. We have found that the differences in the excitation spectra and luminescence decay kinetics of LuAG:Pr crystals and films are caused by involving the LuAl antisite defects and oxygen vacancies in the crystals and Pb 2+ flux related dopants in the films in the excitation processes of the Pr 3+ luminescence. Taking into account these differences, we have determined the energy structure of the Pr 3+ ions in LuAG host and estimated the differences in the energies of creation of excitons bound with the isolated Pr 3+ ions in LuAG:Pr films and the dipole Pr–LuAl antisite defect centers in the crystal counterpart. - Highlights: • Comparison of the luminescent properties of LuAG:Pr single crystals and films. • Superposition of the Pr 3+ and defect centers luminescence of LuAG:Pr crystal. • Different creation energies of an excitons bound with the Pr 3+ in LuAG:Pr crystals and films. • More faster decay kinetics of the Pr 3+ luminescence in LuAG:Pr films. • Low content of slow emission component in LuAG:Pr films.

  10. Peptide receptor radionuclide therapy (PRRT) using Lu-177 DOTA-NOC and Lu-177 DOTA-TATE: Comparative results

    International Nuclear Information System (INIS)

    Wehrmann, C.; Senftleben, S.; Baum, R.P.

    2007-01-01

    Full text: Aim: One of the few treatment options for inoperable neuroendocrine tumors (NET) is peptide receptor radiotherapy with somatostatin analogues. DOTA-NOC shows the highest affinity to the somatostatin receptors (sstr) 3 and 5 and a very high affinity to sstr 2. We compared the dosimetric parameters uptake, half-life (kinetics) and mean absorbed organ and tumor doses of 177 Lu DOTANOC and 177 Lu DOTA-TATE. Methods: 139 patients with neuroendocrine tumors with high sstr expression (verified by Ga-68 DOTA-NOC PET/CT) were studied. 130 patients (57m, 73f; aged 60±11a) were treated with 2.5-7.4 GBq Lu-177 DOTA-TATE and 9 patients (3m, 6f, aged 64±10a) with 3.6-7.4 GBq Lu-177 DOTA-NOC. Whole-body scans were performed after 0.5h, 3h, 24h, 48h, 72h and 96h p.i. Blood samples from 23 patients were obtained after therapy. By means of geometric mean and after background correction, ROI results were used to calculate the estimated absorbed organ and tumor doses according to the MIRD-scheme (OLINDA software). Results: Lu-177 DOTA-NOC showed a higher uptake as compared to Lu-177 DOTATATE (=100%): for whole-body about 38% and in normal tissue 36%, in the spleen 17% and in the kidneys 18%. The tumor uptake was about 5% higher for DOTA-TATE. The effective half-life for whole-body was comparable for both peptides (t1/2a NOC 2.9h vs. TATE 2.4h and t1/2b NOC 54h vs. TATE 56h). In normal tissue, t1/2a was similar (NOC 3.3h; TATE 2.6h) but the t1/2b was longer for DOTA-TATE (NOC 43h; TATE 48h). t1/2b was longer for DOTA-NOC in the spleen (NOC 81h; TATE 72h) and in the kidney (NOC 68.1h; TATE 65h). The mean absorbed dose in the kidney (TATE 5Sv; NOC 6Sv) and spleen (TATE 7Sv; NOC 8Sv) was higher for DOTA-NOC. In the tumor, the t1/2b was higher for DOTA-TATE (NOC 65h; TATE 77h). For DOTA-TATE the whole-body dose was lower (0.27Sv) as compared to DOTA-NOC (0.38 Sv) (significant by unpaired sign test). The estimated mean absorbed tumor doses were 47+/-66 Sv for DOTA-TATE and 35

  11. İki uçlu bozukluk 1 ve iki uçlu bozukluk 2 depresyon tedavisi arasındaki farklar

    OpenAIRE

    Sayar, Kemal

    2013-01-01

    İki uçlu bozukluk 1 ve 2 depresyonları, klinik açıdan farklılıklar gösterebilmektedir. İki uçlu bozukluk 2 ve iki uçlu bozukluk 1 depresyonların tedavisi arasındaki farklar ise tartışmalı bir alandır. Henüz İki uçlu bozukluk 2 depresyon tedavisi konusunda yeterince kanıt birikmemişse de ilk veriler her iki durumun tedavisinde farklar olması gerektiğini düşündürmektedir. Özellikle antidepresan kullanımı konusunda dikkatli olmak gerekmektedir.

  12. Wood-plastic combination

    International Nuclear Information System (INIS)

    Schaudy, R.

    1978-02-01

    A review on wood-plastic combinations is given including the production (wood and plastic component, radiation hardening, curing), the obtained properties, present applications and prospects for the future of these materials. (author)

  13. DESIGNERS’ KNOWLEDGE IN PLASTICS

    DEFF Research Database (Denmark)

    Eriksen, Kaare

    2013-01-01

    The Industrial designers’ knowledge in plastics materials and manufacturing principles of polymer products is very important for the innovative strength of the industry, according to a group of Danish plastics manufacturers, design students and practicing industrial designers. These three groups ...

  14. Beta-glycosidase (amygdalase and linamarase) from Endomyces fibuliger (LU677): formation and crude enzymes properties.

    NARCIS (Netherlands)

    Brimer, L.; Nout, M.J.R.; Tuncel, G.

    1998-01-01

    In our previous studies, the yeast Endomyces fibuliger LU677 was found to degrade amygdalin in bitter apricot seeds. The present investigation shows that E. fibuliger LU677 produces extracellular beta-glycosidase activity when grown in malt extract broth (MEB). Growth was very good at 25 degrees C

  15. Neoadjuvant Treatment of Nonfunctioning Pancreatic Neuroendocrine Tumors with [177Lu-DOTA0,Tyr3]Octreotate

    NARCIS (Netherlands)

    van Vliet, Esther I.; van Eijck, Casper H.; de Krijger, Ronald R.; Nieveen van Dijkum, Elisabeth J.; Teunissen, Jaap J.; Kam, Boen L.; de Herder, Wouter W.; Feelders, Richard A.; Bonsing, Bert A.; Brabander, Tessa; Krenning, Eric P.; Kwekkeboom, Dik J.

    2015-01-01

    Pancreatic neuroendocrine tumors (NETs) are rare neoplasms for which surgery has almost the only potential for cure. When surgery is not possible because of tumor size and vascular involvement, neoadjuvant treatment with [(177)Lu-DOTA(0),Tyr(3)]octreotate ((177)Lu-octreotate) may be an option. We

  16. Crystal growth, spectral and laser properties of Nd:LuAG single crystal

    International Nuclear Information System (INIS)

    Xu, X D; Meng, J Q; Cheng, Y; Li, D Z; Cheng, S S; Wu, F; Zhao, Z W; Wang, X D; Xu, J

    2009-01-01

    Nd:LuAG (Nd:Lu 3 Al 5 O 12 ) crystal was grown by the Czochralski method. X-ray powder diffraction experiments show that the Nd:LuAG crystal crystallizes in the cubic with space group Ia3d and has the cell parameter: a = 1.1907 nm, V = 1.6882 nm 3 . The absorption and fluorescence spectra of Nd:LuAG crystal at room temperature were investigated. With a fiber-coupled diode laser as pump source, the continuous-wave (CW) laser action of Nd:LuAG crystal was demonstrated. The maximum output power at 1064 nm was obtained to be 3.8 W under the incident pump power of 17.3 W, with the optical conversion efficiency 22.0% and the slope efficiency 25.7%

  17. Crystal growth, spectral and laser properties of Nd:LuAG single crystal

    Science.gov (United States)

    Xu, X. D.; Wang, X. D.; Meng, J. Q.; Cheng, Y.; Li, D. Z.; Cheng, S. S.; Wu, F.; Zhao, Z. W.; Xu, J.

    2009-09-01

    Nd:LuAG (Nd:Lu3Al5O12) crystal was grown by the Czochralski method. X-ray powder diffraction experiments show that the Nd:LuAG crystal crystallizes in the cubic with space group Ia3d and has the cell parameter: a = 1.1907 nm, V = 1.6882 nm3. The absorption and fluorescence spectra of Nd:LuAG crystal at room temperature were investigated. With a fiber-coupled diode laser as pump source, the continuous-wave (CW) laser action of Nd:LuAG crystal was demonstrated. The maximum output power at 1064 nm was obtained to be 3.8 W under the incident pump power of 17.3 W, with the optical conversion efficiency 22.0% and the slope efficiency 25.7%.

  18. Green and red luminescence in co-precipitation synthesized Pr:LuAG nanophosphor

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, S. Arun; Kumar, K. Ashok; Gunaseelan, M.; Senthilselvan, J., E-mail: jsselvan@hotmail.com [Department of Nuclear Physics, University of Madras, Guindy Campus, Chennai–600 025, Tamil Nadu (India); Asokan, K. [Materials Science Group, Inter University Accelerator Centre, New Delhi-110067 (India)

    2016-05-06

    Pr:LuAG nanophosphor is an effective candidate in magnetic resonance imaging coupled positron emission tomography (MRI-PET) for medical imaging and scintillator applications. LuAG:Pr (0.05, 0.15 mol%) nanoscale ceramic powders were synthesized by co-precipitation method using urea as precipitant. Effect of antisite defect on structure and luminescence behavior was investigated. Pr:LuAG nanoceramic powders are found crystallized in cubic structure by high temperature calcination at 1400 °C and it shows antisite defect. HR-SEM analysis revealed spherically shaped Pr:LuAG nanoceramic particulate powders with ∼100 nm size. By the excitation at 450 nm, Pr:LuAG nanophosphor exhibit green to red luminescence in the wavelength range of 520 to 680 nm, which is originated from multiplet transition of Pr{sup 3+} ions.

  19. In-beam spectroscopy study of the proton emitter 151Lu

    International Nuclear Information System (INIS)

    Yu, C.; Rykaczewski, K.; Toth, K.S.; Akovali, Y.; Baktash, C.; Galindo-Uribarri, A.; Gross, C.J.; Paul, S.D.; Radford, D.C.; Batchelder, J.C.; Gross, C.J.; Bingham, C.R.; Grzywacz, R.; Kim, S.H.; Weintraub, W.; Ginter, T.N.; Grzywacz, R.; Rykaczewski, K.; Karny, M.; MacDonald, B.D.; Szerypo, J.

    1998-01-01

    Gamma rays decaying from the excited states of the proton-unbound 151 Lu were observed for the first time in an experiment using the 96 Ru( 58 Ni,p2n) 151 Lu reaction. These γ rays were identified by correlating prompt γ radiations at the target position with 151 Lu proton radioactivities at the focal plane of a recoil mass separator. Systematic data on N=80 isotones suggest a possible isomeric level at high spin in 151 Lu. Our measurement was unable to observe such an isomer, but provided an upper limit on its half-life. The observed γ rays in 151 Lu can be interpreted in terms of two possible level structures. copyright 1998 The American Physical Society

  20. Optical spectroscopy and luminescence quenching of LuI3:Ce3+

    International Nuclear Information System (INIS)

    Birowosuto, M.D.; Dorenbos, P.; Haas, J.T.M. de; Eijk, C.W.E. van; Kraemer, K.W.; Guedel, H.U.

    2006-01-01

    Optical spectroscopy of LuI 3 doped with Ce 3+ using ultraviolet and visible light excitation is reported. LuI 3 host excitation and emission and 4f-5d excitation and emission of Ce 3+ are observed. An empirical model based on crystal field splitting was used to estimate the energy of the highest 4f-5d excitation band. The crystal field splitting and centroid shift were compared to those of LuCl 3 :Ce 3+ and LuBr 3 :Ce 3+ . Temperature dependence of X-ray excited luminescence spectra shows thermal quenching, whereas that of the decay curve of Ce 3+ emission excited at the lowest 5d band of Ce 3+ does not indicate the presence of quenching of Ce 3+ emission for temperature below 625K. The quenching in LuI 3 :Ce 3+ therefore occurs before the 5d Ce 3+ emission takes place

  1. Comparative study of optical and scintillation properties of YVO4, (Lu0.5Y0.5)VO4, and LuVO4 single crystals

    International Nuclear Information System (INIS)

    Fujimoto, Yutaka; Yanagida, Takayuki; Yokota, Yuui; Chani, Valery; Kochurikhin, Vladimir V.; Yoshikawa, Akira

    2011-01-01

    Optical and scintillation properties of YVO 4 , (Lu 0.5 Y 0.5 )VO 4 , and LuVO 4 single crystals grown by the Czochralski (CZ) method with RF heating system are compared. All vanadate crystals show high transmittance (∼80%) in the 400-900 nm wavelength range. In both photo- and radio-luminescence spectra, intense peak around 400-500 nm, which was ascribed to the transition from triplet state of VO 4 3- , was clearly observed. The main decay time component was about 38 μs (YVO 4 ), 18 μs ((Lu 0.5 Y 0.5 )VO 4 ), and 17 μs (LuVO 4 ) under 340 nm excitation. The scintillation light yields of YVO 4 , (Lu 0.5 Y 0.5 )VO 4 , and LuVO 4 crystals (obtained from the 137 Cs excited pulse height spectra) were evaluated to be about 11,200, 10,700, and 10,300 ph/MeV, respectively.

  2. Biferroic LuCrO{sub 3}: Structural characterization, magnetic and dielectric properties

    Energy Technology Data Exchange (ETDEWEB)

    Durán, A., E-mail: dural@cnyn.unam.mx [Universidad Nacional Autónoma de México, Centro de Nanociencias y Nanotecnología, Km. 107 Carretera Tijuana-Ensenada, Apartado Postal 14, C.P. 22800 Ensenada, BC (Mexico); Meza F, C.; Morán, E.; Alario-Franco, M.A. [Departamento de Química Inorgánica y Laboratorio Complutense de Altas Presiones, Facultad de Química, Universidad Complutense de Madrid, EU, 28040 Madrid (Spain); Ostos, C., E-mail: ceostoso@gmail.com [Instituto de Química, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín (Colombia)

    2014-02-14

    Multiferroic LuCrO{sub 3} perovskite-type structure (Pbnm) obtained via auto-ignition synthesis was characterized by a combination of X-ray diffraction (XRD) and thermogravimetric (TG) techniques, and through magnetization and permittivity measurements. Results showed that amorphous combustion powders were fully transformed to orthorhombic LuCrO{sub 3} structure at 1200 K after the first LuCrO{sub 4} crystallization at 700 K. The magnetic response displays thermal irreversibility between zero-field-cooling and field-cooling condition which is due to spin canted AF switching at 116 K. Accordingly, a hysteresis loop in the M(H) data confirms weak ferromagnetism in LuCrO{sub 3}. On the other hand, the permittivity measurement shows a broad peak transition typical of relaxor-type ferroelectrics transition at ∼450 K. Electrical conductivity increases as temperature increases showing an anomaly around the diffuse phase transition. The diffuse phase transition and the formation of the charge carriers are discussed in terms of a local distortion around the Lu Site. - Highlights: • Multiferroic LuCrO{sub 3} was successfully obtained via auto-ignition synthesis. • Amorphous powder is transformed first to LuCrO{sub 4} (700 K) and next to LuCrO{sub 3} (1100 K). • The CrO{sub 6} octahedra are tilted away and rotates from the ideal octahedral shape. • LuCrO{sub 3} exhibits a canted AFM transition (116 K) and a relaxor ferroelectric behavior. • Tilting and rotation of CrO{sub 6} octahedra influenced transport properties on LuCrO{sub 3}.

  3. Biferroic LuCrO3: Structural characterization, magnetic and dielectric properties

    International Nuclear Information System (INIS)

    Durán, A.; Meza F, C.; Morán, E.; Alario-Franco, M.A.; Ostos, C.

    2014-01-01

    Multiferroic LuCrO 3 perovskite-type structure (Pbnm) obtained via auto-ignition synthesis was characterized by a combination of X-ray diffraction (XRD) and thermogravimetric (TG) techniques, and through magnetization and permittivity measurements. Results showed that amorphous combustion powders were fully transformed to orthorhombic LuCrO 3 structure at 1200 K after the first LuCrO 4 crystallization at 700 K. The magnetic response displays thermal irreversibility between zero-field-cooling and field-cooling condition which is due to spin canted AF switching at 116 K. Accordingly, a hysteresis loop in the M(H) data confirms weak ferromagnetism in LuCrO 3 . On the other hand, the permittivity measurement shows a broad peak transition typical of relaxor-type ferroelectrics transition at ∼450 K. Electrical conductivity increases as temperature increases showing an anomaly around the diffuse phase transition. The diffuse phase transition and the formation of the charge carriers are discussed in terms of a local distortion around the Lu Site. - Highlights: • Multiferroic LuCrO 3 was successfully obtained via auto-ignition synthesis. • Amorphous powder is transformed first to LuCrO 4 (700 K) and next to LuCrO 3 (1100 K). • The CrO 6 octahedra are tilted away and rotates from the ideal octahedral shape. • LuCrO 3 exhibits a canted AFM transition (116 K) and a relaxor ferroelectric behavior. • Tilting and rotation of CrO 6 octahedra influenced transport properties on LuCrO 3

  4. The infrared radiation spectrum of acupoint taiyuan (LU 9) in asthma patients.

    Science.gov (United States)

    Zhou, Yu; Shen, Xue-yong; Wang, Li-zhen; Wei, Jian-zi; Cheng, Ke

    2012-06-01

    To analyze the distinctive pathological characteristics in the spectrums of spontaneous infrared radiation at the Taiyuan (LU 9) acupoint in patients with asthma. A highly sensitive infrared spectrum detecting device was used to detect the spectrums of spontaneous infrared radiation at Taiyuan (LU 9) in 37 asthma patients and 34 healthy volunteers. Asthma patients had significantly lower infrared intensity than that of the healthy volunteers (P>0.01). Asthma patients had significantly lower overall infrared radiation intensity at the left Taiyuan (LU 9) than that of healthy volunteers (P > 0.05), but there was no significant difference between healthy volunteers and asthma patients at the right Taiyuan (LU 9) (P > 0.05). The infrared radiation intensity of 17 wavelength spots at the left Taiyuan (LU 9) and 4 wavelength spots at the right Taiyuan (LU 9) in asthma patients were significantly lower than those of healthy volunteers (P > 0.05). At 2 microm, the infrared radiation intensity of asthma patients was significantly stronger than that of healthy volunteers (P > 0.05). At 19 wavelength spots in the healthy volunteers and at 4 wave-length spots in the asthma patients, the left Taiyuan (LU 9) showed a significantly stronger intensity than that of the right Taiyuan (LU 9) (P > 0.05S). By Pearson's chi2 test, healthy volunteers had more wavelength spots that were significantly different between the left and right Taiyuan (LU 9) than the asthma patients (P > 0.01). Changes in the infrared spectrum at the Taiyuan (LU 9) acupoint in asthma patients may reflect distinct pathological changes. Certain acupuncture points may be related to specific organs.

  5. Scintillation properties of Ce-doped LuLiF{sub 4} and LuScBO{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Yanagida, Takayuki, E-mail: t_yanagi@tagen.tohoku.ac.jp [IMRAM, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577 (Japan); Fujimoto, Yutaka [IMRAM, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577 (Japan); Kawaguchi, Noriaki [IMRAM, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577 (Japan); Tokuyama Corporation, Shibuya 3-chome, Shibuya-ku, Tokyo 150-8383 (Japan); Yokota, Yuui [IMRAM, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577 (Japan); Kamada, Kei [Materials Research Laboratory, Furukawa, Co. Ltd., 1-25-13 Kannondai, Tsukuba, Ibaragi 305-0856 (Japan); Totsuka, Daisuke [Nihon Kessho Kogaku Co., Ltd., 810-5 Nobe-cho, Tatebayashi, Gunma 374-0047 (Japan); Hatamoto, Shun-Ichi [Corporate Research and Development Center, Mitsui Mining and Smelting Co., Ltd., 1333-2 Haraichi, Ageo Saitama 362-0023 (Japan); Yoshikawa, Akira; Chani, Valery [IMRAM, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577 (Japan)

    2011-10-01

    The crystals of 1 mol% Ce-doped LuLiF{sub 4} (Ce:LLF) grown by the micro-pulling down ({mu}-PD) method and 1 mol% Ce-doped LuScBO{sub 3} (Ce:LSBO) grown by the conventional Czochralski (Cz) method were examined for their scintillation properties. Ce:LLF and Ce:LSBO demonstrated {approx}80% transparency at wavelengths longer than 300 and 400 nm, respectively. When excited by {sup 241}Am {alpha}-ray to obtain radioactive luminescence spectra, Ce{sup 3+} 5d-4f emission peaks were detected at around 320 nm for Ce:LLF and at around 380 nm for Ce:LSBO. In Ce:LSBO, the host luminescence was also observed at 260 nm. By recording pulse height spectra under {gamma}-ray irradiation, the absolute light yield of Ce:LLF and Ce:LSBO was measured to be 3600{+-}400 and 4200{+-}400 ph/MeV, respectively. Decay time kinetics was also investigated using a pulse X-ray equipped streak camera system. The main component of Ce:LLF was {approx}320 ns and that of Ce:LSBO was {approx}31 ns. In addition, the light yield non-proportionality and energy resolution against the {gamma}-ray energy were evaluated.

  6. Plastic value chains

    DEFF Research Database (Denmark)

    Baxter, John; Wahlstrom, Margareta; Zu Castell-Rüdenhausen, Malin

    2014-01-01

    Optimizing plastic value chains is regarded as an important measure in order to increase recycling of plastics in an efficient way. This can also lead to improved awareness of the hazardous substances contained in plastic waste, and how to avoid that these substances are recycled. As an example......, plastics from WEEE is chosen as a Nordic case study. The project aims to propose a number of improvements for this value chain together with representatives from Nordic stakeholders. Based on the experiences made, a guide for other plastic value chains shall be developed....

  7. Biodegradability of Plastics

    Directory of Open Access Journals (Sweden)

    Yutaka Tokiwa

    2009-08-01

    Full Text Available Plastic is a broad name given to different polymers with high molecular weight, which can be degraded by various processes. However, considering their abundance in the environment and their specificity in attacking plastics, biodegradation of plastics by microorganisms and enzymes seems to be the most effective process. When plastics are used as substrates for microorganisms, evaluation of their biodegradability should not only be based on their chemical structure, but also on their physical properties (melting point, glass transition temperature, crystallinity, storage modulus etc.. In this review, microbial and enzymatic biodegradation of plastics and some factors that affect their biodegradability are discussed.

  8. Biodegradability of plastics.

    Science.gov (United States)

    Tokiwa, Yutaka; Calabia, Buenaventurada P; Ugwu, Charles U; Aiba, Seiichi

    2009-08-26

    Plastic is a broad name given to different polymers with high molecular weight, which can be degraded by various processes. However, considering their abundance in the environment and their specificity in attacking plastics, biodegradation of plastics by microorganisms and enzymes seems to be the most effective process. When plastics are used as substrates for microorganisms, evaluation of their biodegradability should not only be based on their chemical structure, but also on their physical properties (melting point, glass transition temperature, crystallinity, storage modulus etc.). In this review, microbial and enzymatic biodegradation of plastics and some factors that affect their biodegradability are discussed.

  9. Challenges in plastics recycling

    DEFF Research Database (Denmark)

    Pivnenko, Kostyantyn; Jakobsen, L. G.; Eriksen, Marie Kampmann

    2015-01-01

    Recycling of waste plastics still remains a challenging area in the waste management sector. The current and potential goals proposed on EU or regional levels are difficult to achieve, and even to partially fullfil them the improvements in collection and sorting should be considerable. A study...... was undertaken to investigate the factors affecting quality in plastics recycling. The preliminary results showed factors primarily influencing quality of plastics recycling to be polymer cross contamination, presence of additives, non-polymer impurities, and polymer degradation. Deprivation of plastics quality......, with respect to recycling, has been shown to happen throughout the plastics value chain, but steps where improvements may happen have been preliminary identified. Example of Cr in plastic samples analysed showed potential spreading and accumulation of chemicals ending up in the waste plastics. In order...

  10. Production and Quality Control of 177Lu-Dotatate [177Lu-dota- try3]-Octreotate: Clinical Application

    International Nuclear Information System (INIS)

    Barboza, M.F. de; Herrerias, R.; Souza, A.A. de; Pereira, G.; Pires, J.A.; Fukumori, N.T.O.; Matsuda, M.M.N.; Almeida, E.V.; Mengatti, J.; Belfer, A.J.; Hilario, L.N.

    2009-01-01

    Introduction: Somatostatin receptors have been identified in different kinds of tumors such as neuroendocrine tumors and tumors of the central nervous system, breast, lung and lymphatic tissue making these receptors potential targets for radionuclide diagnostics and therapy. These observations have served as the biomolecular basis for the clinical use of radiolabeled somatostatin analogues which, at present, are of great interest in nuclear medicine for diagnostic and peptide receptor radionuclide therapy (PRRT) applications. There are only a few treatment modalities for metastasized neuroendocrine gastroenteropancreatic (GEP) tumors. Besides surgery, (chemo)-embolization, chemotherapy, and treatment with somatostatin (SST) analogs, peptide receptor radionuclide therapy (PRRT) offers therapeutic strategy, as the majority of GEP tumors possess somatostatin receptors (SSTRs). Somatostatin analogs featuring a DOTA-chelator can be radiolabeled with the β-emitters radioisotopes, Yttrium-90 ( 90 Y) and Lutetium-177 ( 177 Lu) for PRRT. Analogs frequently used for therapy are: [DOTA-Tyr 3 ]-octreotide and [DOTA-Tyr 3 ]octreotate. In the latter compound, the alcohol threoninol at the C-terminal of the octreotide has been replaced by the natural threonin amino acid. This alteration resulted in an analog: (Tyr 3 -octreotate), which showed increased affinity for sst2, compared to both [Tyr 3 ]-octreotide and [Phe 1 ]octreotide 'in-vitro' and 'in-vivo'. Clinical studies in patients with different SST-positives tumors proved advantages of [ 177 Lu- DOTA-Tr 3 ]-octreate for therapy. PRRT with radiolabeled somatostatin analogs was shown to be effective in patients with SST2-positive-size reduction, improving quality of life and survival. Objective: The aim of this work was to present the production and the quality control of 177 Lu-Tyr 3 ---octreotate, using DOTA (1,4,7,10-tetrazacyclododecane-N,N',N',N''-tetra acetic acid) as chelating agent at the Radiopharmacy Directory, IPEN

  11. Quadrupole moments of wobbling excitations in 163Lu

    International Nuclear Information System (INIS)

    Goergen, A.; Clark, R.M.; Cromaz, M.; Fallon, P.; Lee, I.Y.; Macchiavelli, A.O.; Ward, D.; Hagemann, G.B.; Sletten, G.; Huebel, H.; Bengtsson, R.

    2004-01-01

    Lifetimes of states in the triaxial strongly deformed bands of 163 Lu have been measured with the Gammasphere spectrometer using the Doppler-shift attenuation method. The bands have been interpreted as wobbling-phonon excitations from the characteristic electromagnetic properties of the transitions connecting the bands. Quadrupole moments are extracted for the zero-phonon yrast band and, for the first time, for the one-phonon wobbling band. The very similar results found for the two bands suggest a similar intrinsic structure and support the wobbling interpretation. While the in-band quadrupole moments for the bands show a decreasing trend towards higher spin, the ratio of the interband to the in-band transition strengths remains constant. Both features can be understood by a small increase in triaxiality towards higher spin. Such a change in triaxiality is also found in cranking calculations, to which the experimental results are compared

  12. Production of {sup 177}Lu for targeted radionuclide therapy: Available options

    Energy Technology Data Exchange (ETDEWEB)

    Dah, Ashutosh [Isotope Production and Applications Division, Bhabha Atomic Research Centre (BARC), Mumbai (India); Pillai, Maroor Raghavan Ambikalmajan [Molecular Group of Companies. Kerala (India); Knapp, Furn F. Jr. [Medical Isotopes Program, Isotope Dept. Group, Oak Ridge National Laboratory (ORNL), Oak Ridge (United States)

    2015-06-15

    This review provides a comprehensive summary of the production of {sup 177}Lu to meet expected future research and clinical demands. Availability of options represents the cornerstone for sustainable growth for the routine production of adequate activity levels of {sup 177}Lu having the required quality for preparation of a variety of {sup 177}Lu-labeled radiopharmaceuticals. The tremendous prospects associated with production of {sup 177}Lu for use in targeted radionuclide therapy (TRT) dictate that a holistic consideration should evaluate all governing factors that determine its success. While both “direct” and “indirect” reactor production routes offer the possibility for sustainable {sup 177}Lu availability, there are several issues and challenges that must be considered to realize the full potential of these production strategies. This article presents a mini review on the latest developments, current status, key challenges and possibilities for the near future. A broad understanding and discussion of the issues associated with {sup 177}Lu production and processing approaches would not only ensure sustained growth and future expansion for the availability and use of {sup 177}Lu-labeled radiopharmaceuticals, but also help future developments.

  13. Theoretical investigations on the high light yield of the LuI3:Ce scintillator

    International Nuclear Information System (INIS)

    Vasil'ev, A.N.; Iskandarova, I.M.; Scherbinin, A.V.; Markov, I.A.; Bagatur'yants, A.A.; Potapkin, B.V.; Srivastava, A.M.; Vartuli, J.S.; Duclos, S.J.

    2009-01-01

    The extremely high scintillation efficiency of lutetium iodide doped by cerium is explained as a result of at least three factors controlling the energy transfer from the host matrix to activator. We propose and theoretically validate the possibility of a new channel of energy transfer to excitons and directly to cerium, namely the Auger process when Lu 4f hole relaxes to the valence band hole with simultaneous creation of additional exciton or excitation of cerium. This process should be efficient in LuI 3 , and inefficient in LuCl 3 . To justify this channel, we perform calculations of density of states using a periodic plane-wave density functional approach. The second factor is the increase of the efficiency of valence hole capture by cerium in the row LuCl 3 -LuBr 3 -LuI 3 . The third one is the increase of the efficiency of energy transfer from self-trapped excitons to cerium ions in the same row. The latter two factors are verified by cluster ab initio calculations. We estimate either the relaxation of these excitations and barriers for the diffusion of self-trapped holes (STH) and self-trapped exciton (STE). The performed estimations theoretically justify the high LuI 3 :Ce 3+ scintillator yield.

  14. [{sup 177}Lu]pertuzumab: experimental studies on targeting of HER-2 positive tumour cells

    Energy Technology Data Exchange (ETDEWEB)

    Persson, Mikael; Gedda, Lars [Uppsala University, Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala (Sweden); Uppsala University, Experimental Urology, Rudbeck Laboratory, Uppsala (Sweden); Tolmachev, Vladimir; Andersson, Karl; Carlsson, Joergen [Uppsala University, Biomedical Radiation Sciences, Rudbeck Laboratory, Uppsala (Sweden); Sandstroem, Mattias [Uppsala University, Medical Radiation Physics, Uppsala University Hospital, Uppsala (Sweden)

    2005-12-01

    The new antibody pertuzumab (Omnitarg) targets the dimerisation subdomain of HER-2. The purpose of this study was to analyse whether pertuzumab retains HER-2 targeting capacity after labelling with the therapeutically interesting beta emitter {sup 177}Lu and to make initial characterisations in vitro and in vivo. Pertuzumab was conjugated with isothiocyanate-benzyl-CHX-A{sup ''}-DTPA and chelated to {sup 177}Lu. Immunoreactivity, affinity, cellular retention and internalisation were analysed using SKOV-3 cells. The affinity of non-radioactive pertuzumab was measured using a surface plasmon resonance biosensor. In vivo targeting and specific binding were assessed in Balb/c (nu/nu) mice carrying SKOV-3 xenografts. The biodistribution of {sup 177}Lu was determined 1, 3 and 7 days after [{sup 177}Lu]pertuzumab administration. Gamma camera images were taken after 3 days. The immunoreactivity of [{sup 177}Lu]pertuzumab was 85.8{+-}1.3%. The affinity of non-radioactive pertuzumab was 1.8{+-}1.1 nM, and that of [{sup 177}Lu]pertuzumab, 4.1{+-}0.7 nM. The cellular retention after 5 h pre-incubation was 90{+-}2% at 20 h. The targeting was HER-2 specific both in vitro and in vivo, since excess amounts of non-labelled antibody inhibited the uptake of labelled antibody (p<0.0001 and p<0.01, respectively). The biodistribution and gamma camera images of {sup 177}Lu showed extensive tumour uptake. Normal tissues had a surprisingly low uptake. Pertuzumab was efficiently labelled with {sup 177}Lu and showed good intracellular retention and HER-2 specific binding both in vitro and in vivo. The gamma camera images and the biodistribution study gave excellent tumour targeting results. Thus, [{sup 177}Lu]pertuzumab is of interest for further studies aimed at radionuclide therapy. (orig.)

  15. [{sup 177}Lu]DOTA-anti-CD20: Labeling and pre-clinical studies

    Energy Technology Data Exchange (ETDEWEB)

    Audicio, Paola F., E-mail: paudicio@cin.edu.u [Departamento de Radiofarmacia, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Republica, Mataojo 2055, 11400 Montevideo (Uruguay); Castellano, Gustavo, E-mail: gcas@famaf.unc.edu.a [FaMAF, Universidad Nacional de Cordoba, Ciudad Universitaria, 5016 Cordoba (Argentina); Tassano, Marcos R.; Rezzano, Maria E.; Fernandez, Marcelo [Departamento de Radiofarmacia, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Republica, Mataojo 2055, 11400 Montevideo (Uruguay); Riva, Eloisa [Clinica Hematologica ' Prof. Dra. L. Diaz' , Hospital de Clinicas. Av. Italia. sn, Montevideo (Uruguay); Robles, Ana; Cabral, Pablo; Balter, Henia; Oliver, Patricia [Departamento de Radiofarmacia, Centro de Investigaciones Nucleares, Facultad de Ciencias, Universidad de la Republica, Mataojo 2055, 11400 Montevideo (Uruguay)

    2011-07-15

    Anti-CD20 (Rituximab), a specific chimeric monoclonal antibody used in CD20-positive Non-Hodgkin's Lymphoma, was conjugated to a bifunctional quelate (DOTA) and radiolabeled with {sup 177}Lu through a simple method. [{sup 177}Lu]-DOTA-anti-CD20 was obtained with a radiochemical purity higher than 97%, and showed good chemical and biological stability, maintaining its biospecificity to CD20 antigens. Monte Carlo simulation showed high doses deposited on a spheroid tumor mass model. This method seems to be an appropriate alternative for the production of [{sup 177}Lu]-DOTA-anti-CD20 as therapeutic radiopharmaceutical.

  16. First observation of yrast band in odd-odd 162Lu

    International Nuclear Information System (INIS)

    Zhang, Y.H.; Yuan, G.J.; Liu, X.A.

    1996-01-01

    High spin states of the odd-odd 162 Lu nucleus have been studied via 147 Sm( 19 F, 4nγ) 162 Lu reaction at 95MeV beam energy. Level scheme for yrast band based on π[h 11/2 ] υ[i 13/2 ] quasiparticle configuration was established up to I π =(23 - ) for the first time. This band shows the signature inversion in energy before backbending generally appeared in this mass region. It is stressed that the signature splitting in 162 Lu is larger than that in the 160 Tm nucleus. (orig.)

  17. Development of a therapeutic radiopharmaceutical 177Lu-DOTA- Minigastrin for potential use in PRRT

    International Nuclear Information System (INIS)

    Lopez Bularte, A.C.; Nevares, N.N.; Zapata, A.M.; Perez, J.H.; Crudo, J.L.; Puerta Yepes, N.; Rojo, A.M.

    2010-01-01

    The aim of this work is to obtain 177 Lu-DOTA-Minigastrin with high radiochemical purity (RP) and the highest specific activity (Ae) as possible, using a locally produced (Nuclear Reactor RA-3, Ezeiza Atomic Center) 177 LuCl 3 of an intermediate level of Ae (between 6.36 to 17.95 Ci/mg of 176 Lu) ) and also to perform in vitro and in vivo stability tests, dose calculation in normal mice and its extrapolation to a human model. (authors) [es

  18. Lu AA21004, a novel multimodal antidepressantwith activity exerted through serotonergic targets

    DEFF Research Database (Denmark)

    Mork, A.; Pehrson, A.; Montezinho, L. C. P.

    2012-01-01

    Background: Lu AA21004 is a multimodal antidepressant that functions as a 5-HT3 and 5-HT7 receptor antagonist, 5-HT1B receptor partial agonist, 5-HT1A receptor agonist and inhibitor of the 5-HT transporter in vitro. Here we investigated preclinical effects of Lu AA21004 1) on target occupancies, 2...... (5-HT), noradrenaline (NA), dopamine (DA), acetylcholine (ACh), histamine (Hist)] were measured by microdialysis. Antidepressant potential was assessed in the forced swim test using Flinders Sensitive Line (FSL) rats. Moreover, effects of Lu AA21004 on acquisition, consolidation and recall...

  19. Handbook of Plastic Welding

    DEFF Research Database (Denmark)

    Islam, Aminul

    The purpose of this document is to summarize the information about the laser welding of plastic. Laser welding is a matured process nevertheless laser welding of micro dimensional plastic parts is still a big challenge. This report collects the latest information about the laser welding of plastic...... materials and provides an extensive knowhow on the industrial plastic welding process. The objectives of the report include: - Provide the general knowhow of laser welding for the beginners - Summarize the state-of-the-art information on the laser welding of plastics - Find the technological limits in terms...... of design, materials and process - Find the best technology, process and machines adaptive to Sonion’s components - Provide the skills to Sonion’s Design Engineers for successful design of the of the plastic components suitable for the laser welding The ultimate goal of this report is to serve...

  20. Our plastic age.

    Science.gov (United States)

    Thompson, Richard C; Swan, Shanna H; Moore, Charles J; vom Saal, Frederick S

    2009-07-27

    Within the last few decades, plastics have revolutionized our daily lives. Globally we use in excess of 260 million tonnes of plastic per annum, accounting for approximately 8 per cent of world oil production. In this Theme Issue of Philosophical Transactions of the Royal Society, we describe current and future trends in usage, together with the many benefits that plastics bring to society. At the same time, we examine the environmental consequences resulting from the accumulation of waste plastic, the effects of plastic debris on wildlife and concerns for human health that arise from the production, usage and disposal of plastics. Finally, we consider some possible solutions to these problems together with the research and policy priorities necessary for their implementation.

  1. Our plastic age

    Science.gov (United States)

    Thompson, Richard C.; Swan, Shanna H.; Moore, Charles J.; vom Saal, Frederick S.

    2009-01-01

    Within the last few decades, plastics have revolutionized our daily lives. Globally we use in excess of 260 million tonnes of plastic per annum, accounting for approximately 8 per cent of world oil production. In this Theme Issue of Philosophical Transactions of the Royal Society, we describe current and future trends in usage, together with the many benefits that plastics bring to society. At the same time, we examine the environmental consequences resulting from the accumulation of waste plastic, the effects of plastic debris on wildlife and concerns for human health that arise from the production, usage and disposal of plastics. Finally, we consider some possible solutions to these problems together with the research and policy priorities necessary for their implementation. PMID:19528049

  2. Additional lesions detected in therapeutic scans with 177Lu-DOTATATE reflect higher affinity of 177Lu-DOTATATE for somatostatin receptors.

    Science.gov (United States)

    Mirzaei, Siroos; Bastati, Brigitte; Lipp, Rainer W; Knoll, Peter; Zojer, Niklas; Ludwig, Heinz

    2011-01-01

    Peptide receptor-targeted radionuclide therapy (PRRT) of somatostatin receptor (SR)-expressing neuroendocrine tumors (NETs) has become an established therapeutic option in patients with advanced NETs. The aim of this study was to compare the lesion detection rate of (99m)Tc-EDDA/HYNIC-TOC, a newly developed tracer for NET imaging, with (177)Lu-DOTATATE used for PRRT. 8 patients (4 women, 4 men, age range 46-76 years) with histologically proven NETs, who showed high SR loads by (99m)Tc-EDDA/HYNIC-TOC scintigraphy, were treated with (177)Lu-DOTATATE. After treatment, all patients were subjected to whole-body scintigraphy with additional low-dose single-photon emission computed tomography (SPECT-CT) of the chest and abdomen. All patients demonstrated (177)Lu-DOTATATE accumulation in all lesions previously detected by (99m)Tc- EDDA/HYNIC-TOC scintigraphy. Three patients showed additional lesions in the liver and lungs. SPECT-CT after (177)Lu-DOTATATE therapy may be helpful in detecting additional lesions not seen using (99m)Tc-EDDA/HYNIC-TOC. This could reflect the broader affinity of (177)Lu-DOTATATE for SRs compared with (99m)Tc-EDDA/HYNIC-TOC. Copyright © 2011 S. Karger AG, Basel.

  3. Plastic Pollution from Ships

    OpenAIRE

    Čulin, Jelena; Bielić, Toni

    2016-01-01

    The environmental impact of shipping on marine environment includes discharge of garbage. Plastic litter is of particular concern due to abundance, resistance to degradation and detrimental effect on marine biota. According to recently published studies, a further research is required to assess human health risk. Monitoring data indicate that despite banning plastic disposal at sea, shipping is still a source of plastic pollution. Some of the measures to combat the problem are discussed.

  4. ENVIRONMENTAL ISSUE-PLASTIC

    OpenAIRE

    Sunita Shakle

    2017-01-01

    Polythene is the most common plastic, the annual global production is approximately 60 million tones, and its primary use is in packing. Plastic bags pollute soil and waters and kill thousands of marine generalize plastic bags are not biodegradable they clog water ways, spoil the land scape and end up in landfills. Where they may take 1000 year or more to break down into ever smaller particals that continue to pollution the soil and water.

  5. Our plastic age

    OpenAIRE

    Thompson, Richard C.; Swan, Shanna H.; Moore, Charles J.; vom Saal, Frederick S.

    2009-01-01

    Within the last few decades, plastics have revolutionized our daily lives. Globally we use in excess of 260 million tonnes of plastic per annum, accounting for approximately 8 per cent of world oil production. In this Theme Issue of Philosophical Transactions of the Royal Society, we describe current and future trends in usage, together with the many benefits that plastics bring to society. At the same time, we examine the environmental consequences resulting from the accumulation of waste pl...

  6. Plasticity: modeling & computation

    National Research Council Canada - National Science Library

    Borja, Ronaldo Israel

    2013-01-01

    .... "Plasticity Modeling & Computation" is a textbook written specifically for students who want to learn the theoretical, mathematical, and computational aspects of inelastic deformation in solids...

  7. Synaptic Plasticity and Nociception

    Institute of Scientific and Technical Information of China (English)

    ChenJianguo

    2004-01-01

    Synaptic plasticity is one of the fields that progresses rapidly and has a lot of success in neuroscience. The two major types of synaptie plasticity: long-term potentiation ( LTP and long-term depression (LTD are thought to be the cellular mochanisms of learning and memory. Recently, accumulating evidence suggests that, besides serving as a cellular model for learning and memory, the synaptic plasticity involves in other physiological or pathophysiological processes, such as the perception of pain and the regulation of cardiovascular system. This minireview will focus on the relationship between synaptic plasticity and nociception.

  8. Plastics and health risks.

    Science.gov (United States)

    Halden, Rolf U

    2010-01-01

    By 2010, the worldwide annual production of plastics will surpass 300 million tons. Plastics are indispensable materials in modern society, and many products manufactured from plastics are a boon to public health (e.g., disposable syringes, intravenous bags). However, plastics also pose health risks. Of principal concern are endocrine-disrupting properties, as triggered for example by bisphenol A and di-(2-ethylhexyl) phthalate (DEHP). Opinions on the safety of plastics vary widely, and despite more than five decades of research, scientific consensus on product safety is still elusive. This literature review summarizes information from more than 120 peer-reviewed publications on health effects of plastics and plasticizers in lab animals and humans. It examines problematic exposures of susceptible populations and also briefly summarizes adverse environmental impacts from plastic pollution. Ongoing efforts to steer human society toward resource conservation and sustainable consumption are discussed, including the concept of the 5 Rs--i.e., reduce, reuse, recycle, rethink, restrain--for minimizing pre- and postnatal exposures to potentially harmful components of plastics.

  9. Intrinsic magnetic properties of hexagonal LuFeO3 and the effects of nonstoichiometry

    Directory of Open Access Journals (Sweden)

    Jarrett A. Moyer

    2014-01-01

    Full Text Available We used oxide molecular-beam epitaxy in a composition-spread geometry to deposit hexagonal LuFeO3 (h-LuFeO3 thin films with a monotonic variation in the Lu/Fe cation ratio, creating a mosaic of samples that ranged from iron rich to lutetium rich. We characterized the effects of composition variation with x-ray diffraction, atomic force microscopy, scanning transmission electron microscopy, and superconducting quantum interference device magnetometry. After identifying growth conditions leading to stoichiometric film growth, an additional sample was grown with a rotating sample stage. From this stoichiometric sample, we determined stoichiometric h-LuFeO3 to have a TN = 147 K and Ms = 0.018 μB/Fe.

  10. High-Spin Structure in Odd-Odd 160Lu Nucleus

    International Nuclear Information System (INIS)

    Wang Lie-Lin; Lu Jing-Bin; Yang Dong; Ma Ke-Yan; Yin Li-Chang; Zhou Yin-Hang; Wu Xiao-Guang; Wen Shu-Xian; Li Guang-Sheng; Yang Chun-Xiang

    2012-01-01

    The high-spin states of 160 Lu are populated by the fusion-evaporation reaction 144 Sm( 19 F,3n) 160 Lu at beam energies of 90 and 106 MeV. A new level scheme of 160 Lu is established. A possible isomeric state based on the πh 11/2 νh 9/2 configuration is observed. The new decoupled band with the configuration of πd 3/2 [411]1/2 + νi 13/2 [660]1/2 + is established, and the configurations of these similar decoupled bands in the neighboring odd-odd 162−166 Lu nuclei are suggested. A positive parity coupled band is assigned as the πd 5/2 [402]5/2 + νi 13/2 [660]1/2 + configuration. (nuclear physics)

  11. A routine high-precision method for Lu-Hf isotope geochemistry and chronology

    Science.gov (United States)

    Patchett, P.J.; Tatsumoto, M.

    1981-01-01

    A method for chemical separation of Lu and Hf from rock, meteorite and mineral samples is described, together with a much improved mass spectrometric running technique for Hf. This allows (i) geo- and cosmochronology using the176Lu???176Hf+??- decay scheme, and (ii) geochemical studies of planetary processes in the earth and moon. Chemical yields for the three-stage ion-exchange column procedure average 90% for Hf. Chemical blanks are international mass spectrometric standard; suitable aliquots, prepared from a single batch of JMC 475, are available from Denver. Lu-Hf analyses of the standard rocks BCR-1 and JB-1 are given. The potential of the Lu-Hf method in isotope geochemistry is assessed. ?? 1980 Springer-Verlag.

  12. lu ja liikumine kui ruumipraktikad = Memory and motion as spatial practices / Morten Lund

    Index Scriptorium Estoniae

    Lund, Morten, 1972-

    2015-01-01

    Artiklis on käsitletud nelja uurimust ruumist, mis illustreerivad võimalusi, kuidas sisearhitektuur võib kaasata mälu ja liikumise kui ruumilised praktikad läbi ruumilise kunsti ning 1:1 eksperimentide

  13. Luminescence and scintillation properties of LuPO4-Ce nanoparticles

    International Nuclear Information System (INIS)

    Vistovskyy, V.; Malyy, T.; Pushak, A.; Vas’kiv, A.; Shapoval, A.; Mitina, N.; Gektin, A.; Zaichenko, A.; Voloshinovskii, A.

    2014-01-01

    Study of the spectral-luminescence parameters of LuPO 4 -Ce nanoparticles upon the excitation by X-ray quanta and synchrotron radiation with photon energies of 4–25 eV was performed. Nanoparticles with mean size about a=35 nm and nanoparticles with size less than 12 nm reveal the different structures of cerium centers. Luminescence efficiency of LuPO 4 -Ce nanoparticles of a 4 -Ce nanoparticles studied using synchrotron and X-ray excitation. • Different structure of Ce 3+ -centers has been revealed for LuPO 4 -Ce nanoparticles. • Luminescence of LuPO 4 -Ce with size less than 12 nm is strongly quenched upon the X-ray excitation

  14. Gamma radiation exposure of accompanying persons due to Lu-177 patients

    Directory of Open Access Journals (Sweden)

    Kovan Bilal

    2015-01-01

    Full Text Available Neuroendocrine tumours (NET are cancers usually observed and arisen in the stomach, intestine, pancreas and breathing system. Recently, radionuclide therapy applications with Lu-177 peptide compound are rapidly growing; especially effective clinical results are obtained in the treatment of well-differentiated and metastatic NET. In this treatment, Lu-177-DOTA, a beta emitter radioisotope in the radiopharmaceutical form, is given to the patient by intravenous way. Lu-177 has also gamma rays apart from beta rays. Gamma rays have 175 keV average energy and these gamma rays should be under the control in terms of radiation protection. In this study, we measured the exposure dose from the Lu-177 patient.

  15. Mixed Messages from Garnet Lu-Hf and Sm-Nd Geochronology

    Science.gov (United States)

    Vervoort, J. D.; Wang, D.; Johnson, T. A.

    2017-12-01

    Garnet geochronology provides important information on the timing and conditions of metamorphism. As a major indicator mineral formed during metamorphism, its direct dating can not only help establish the timing of metamorphism, provide the "t" for P-T-t paths, but also, if the dated garnet can be placed in a textural context, can provide information on the timing of deformational features. With advances in chemistry and mass spectrometry, garnet Lu-Hf and Sm-Nd geochronology has become an important geochronological tool and we can now reliably (if not routinely) date a wide variety of garnet compositions formed under diverse conditions. In the course of dating a variety of lithologies using both Lu-Hf and Sm-Nd isotope systems, however, some intriguing results have emerged. Although there are many examples where the Lu-Hf and Sm-Nd systems give the same date within uncertainty, there are also many cases where these systems yield significantly different dates, and the differences between these dates can be considerable—many 10's of Ma of and even 100's of Ma. For example, in garnet-bearing Mesoproterozoic gneisses from across the Blue Ridge Province in Virginia, both Lu-Hf and Sm-Nd analyses (determined on the same solutions) define narrow time spans, but with the Sm-Nd dates systematically younger (for orthogneisses Lu-Hf dates are 1032 to 1019 Ma whereas Sm-Nd dates are 965 to 949 Ma—a difference of 67 to 80 Ma). There are many other examples of systematically younger Sm-Nd garnet dates in both the literature and with our ongoing research. Potential explanations for these differences include: 1) strong partitioning of Lu into garnet during growth yielding ages weighted toward the beginning of growth; 2) faster Lu diffusion from high Lu regions after garnet formation, potentially leading to isochron rotation and anomalously old Lu-Hf dates; and 3) differences in closure temperatures of the two isotope systems. We will review several examples of divergent Lu

  16. The impact of repeated cycles of radioligand therapy using [{sup 177}Lu]Lu-PSMA-617 on renal function in patients with hormone refractory metastatic prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Yordanova, Anna; Becker, Anja; Eppard, Elisabeth; Kuerpig, Stefan; Essler, Markus; Ahmadzadehfar, Hojjat [University Hospital Bonn, Department of Nuclear Medicine, Bonn (Germany); Fisang, Christian [University Hospital Bonn, Department of Urology, Bonn (Germany); Feldmann, Georg [University Hospital Bonn, Department of Internal Medicine, MED3, Bonn (Germany)

    2017-08-15

    [{sup 177}Lu]Lu-PSMA-617 is a well-tolerated therapy for the treatment of metastatic prostate cancer. However, because of the mainly renal excretion of the tracer, the kidneys are one of the most limiting organs. The purpose of this study was to examine the post-therapeutic changes in renal function over time and to identify risk factors for developing renal toxicity. We also tested the reliability of markers for renal function monitoring. Fifty-five patients with castrate-resistant metastatic prostate cancer treated with at least three cycles of [{sup 177}Lu]Lu-PSMA-617 were investigated. Renal function was assessed through laboratory tests (creatinine, GFR, cystatin C) and Tc-99 m-MAG3 measurements. Adverse events were classified according to the Common Terminology Criteria for Adverse Events (CTCAE) v4.0. To identify risk factors for renal toxicity, we used Pearson's correlation coefficient and the corresponding p values. None of the 55 patients experienced severe nephrotoxicity (grade 3/4). In 14 patients (25%), we observed increased creatinine levels of CTC 1 or 2 . There were 16 cases of increased GFR (grade 1/2). At the baseline, only 14 patients had elevated cystatin C. However, post-therapeutic cystatin C was elevated in 32 patients (58%). A significant effect on renal function was found for age (p = 0.049), hypertension (p = 0.001) and pre-existing kidney disease (p = 0.001). The most reliable predictive markers of nephrotoxicity were TER-MAG3 and cystatin C. Renal toxicity in patients treated with [{sup 177}Lu]Lu-PSMA-617 was low. There was no (sub)acute grade 3 or 4 nephrotoxicity. (orig.)

  17. In Vivo Measurement and Characterization of a Novel Formulation of [177Lu]-DOTA-Octreotate

    Directory of Open Access Journals (Sweden)

    Dale Bailey

    2016-01-01

    Full Text Available Objective(s:Lutetium-177 can be made with high specific activity and with no other isotopes of lutetium present, referred to as “No Carrier Added” (NCA 177Lu. We have radiolabelled DOTA-conjugated peptide DOTA‐(Tyr3‐octreotate with NCA 177Lu (“NCA-LuTATE” and used it in nearly 40 therapeutic administrations for subjects with neuroendocrine tumours or meningiomas. In this paper, we report on our initial studies on aspects of the biodistribution and dosimetry of NCA-LuTATE from gamma camera 2D whole body (WB and quantitative 3D SPECT (qSPECT 177Lu imaging. Methods: Thirteen patients received 39 NCA-LuTATE injections. Extensive WB planar and qSPECT imaging was acquired at approximately 0.5, 4, 24 and 96 h to permit estimates of clearance and radiation dose estimation using MIRD-based methodology (OLINDA-EXM. Results:The average amount of NCA-Lutate administered per cycle was 7839±520 MBq. Bi-exponential modelling of whole body clearance showed half lives for the fast & slow components of t½=2.1±0.6 h and t½=58.1±6.6 h respectively. The average effective dose to kidneys was 3.1±1.0 Gy per cycle. In eight patients completing all treatment cycles the average total dose to kidneys was 11.7±3.6 Gy. Conclusions: We have shown that NCA-LuTATE has an acceptable radiation safety profile and is a suitable alternative to Carrier-Added 177Lu formulations. The fast component of the radiopharmaceutical clearance was closely correlated with baseline renal glomerular filtration rate, and this had an impact on radiation dose to the kidneys. In addition, it has less radioactive waste issues and requires less peptide per treatment.

  18. Yrast bands and signature inversion in double odd 162,164Lu

    International Nuclear Information System (INIS)

    Cardona, M.A.; Hojman, D.; Kreiner, A.J.; Somacal, H.; Davidson, J.; Davidson, M.; Acuna, D. de; Napoli, D.R.; Rico, J.; Burch, R.; Bazzacco, D.; Lenzi, S.M.; Rossi Alvarez, C.; Blasi, N.; Lo Bianco, G.

    1996-01-01

    High spin rotational bands in 162 Lu and 164 Lu have been studied by means of the 139 La( 28 Si,5n) and 139 La( 29(30) Si,4(5)n) reactions respectively. For both nuclei the yrast sequence which is associated with the πh 11/2 x νi 13/2 configuration shows the signature inversion feature. (orig.)

  19. Natural radioactive nuclides 138La and 176Lu in rare earth ore samples

    International Nuclear Information System (INIS)

    Zhang Weiping; Shen Jianfeng; Lu Zhaolun; Jiang Rangrong

    1993-01-01

    The contents of 1 '3 8 La and 176 Lu in some rare earth mines have been measured with a HPGE γ spectrometer. The measurements show that the contents of 138 La and 176 Lu in one rare earth mine are remarkably different from those in the other and they do not display a proportional relation, and that the contents of 40 K in this mine are very low

  20. Linear thermal expansivity and Cp measurements for LuHx and LuDx (x=0.005 and 0.053) single crystals

    International Nuclear Information System (INIS)

    Swenson, C.A.

    1996-01-01

    Linear thermal expansivity (α) measurements from 1 to 300 K and heat capacity (C p ) measurements from 1 to 110 K are reported for single crystals of the α-Lu hexagonal alloys LuH x and LuD x (x=0.005 and 0.053). The C p data confirm and extend to 110 K earlier 1 to 20 K measurements on LuH x alloys, and show that isotope effects, if any, are small. The small x dependences of the C p close-quote s above 8 K can be associated with small increases in the Debye temperature Θ 0 . This latter interpretation, which is consistent with ultrasonic and other results for these alloys, is valid only if C p is expressed as mJ/gmolK (essentially, per mole of Lu ions). Results are in agreement with the previous conclusion from more extensive polycrystalline LuH x data that the shape of the low-temperature C p vs T relation for x≤0.015 is qualitatively different from that for x≥0.032. The linear thermal expansivities of the c-axis alloys, even for x=0.005, are significantly smaller (by from 3% to 20%) than those for the pure crystals, with large isotope effects and a large, nonlinear x dependence for the low-temperature expansivity data. Other types of data have shown a feature near 170 K which is associated with the completion of pairing of the hydrogens along the c axis in next-nearest-neighbor tetrahedral sites. A distinct (approximately 15 K wide) change in α which is observed near this temperature for each alloy, except for a-axis LuD 0.005 , provides the most direct evidence of such a transition. The temperature of the c-axis discontinuity is slightly isotope and x dependent, and scales approximately with x [+24% on warming for LuH(or D) 0.053 ]. (Abstract Truncated)

  1. The coordination number of Lu(III) in a mixed system of methanol and water

    International Nuclear Information System (INIS)

    Arisaka, M.; Takuwa, N.; Suganuma, H.

    2000-01-01

    The stability constants (β 1(F) ) of the monofluoro complex of Lu(III) and those (β 1(Cl) ) of the monochloride solvent-shared ion-pair of Lu(III) have been determined in mixed solvents of methanol and water at 0.10 and 1.00 mol x dm -3 ionic strengths, respectively. The variation in lnβ 1(F) with an increase in the mole fraction of methanol (X s ) in the mixed solvent system showed an acute-angled convex inflection point at X s ∼ 0.12, an acute-angled concave inflection point at X s ∼ 0.22, and another acute-angled convex inflection point at X s ∼ 0.27. It was concluded that the first and the second convex inflection points denoted the CN of Lu 3+ from CN = 8 to a mixture of CN = 8 and 7 and from CN = 8 and 7 to a mixture containing CN = 6, respectively. The concave point is the starting point of a change in the CN of Lu(III) in LuF 2+ from CN = 8 to a mixture of CN = 8 and 7. The values at two inflection points of the CN around Lu 3+ are consistent with the inflection points of the variation in the values of lnβ 1(Cl ) versus the dielectric constant of the mixed solvent. (author)

  2. Overview of Development and Formulation of ¹⁷⁷Lu-DOTA-TATE for PRRT.

    Science.gov (United States)

    Breeman, Wouter A P; Chan, Ho Sze; de Zanger, Rory M S; Konijnenberg, Mark K; de Blois, Erik

    2016-01-01

    Peptide receptor radionuclide therapy (PRRT) using radiolabeled somatostatin analogs has become an established procedure for the treatment of patients suffering from inoperable neuroendocrine cancers over-expressing somatostatin receptors. Success of PRRT depends on the availability of the radiolabeled peptide with adequately high specific activity, so that required therapeutic efficacy can be achieved without saturating the limited number of receptors available on the target lesions. Specific activity of the radionuclide and the radiolabeled somatostatin analog are therefore an important parameters. Although these analogs have been investigated and improved, and successfully applied for PRRT for more than 15 years, there are still many possibilities for further improvements that fully exploit PRRT with 177Lu-DOTA-TATE. The here summarized data presented herein on increased knowledge of the components of 177Lu-DOTA-TATE (especially the purity of 177Lu and specific activity of 177Lu) and the reaction kinetics during labeling 177Lu-DOTA-TATE clearly show that the peptide dose and dose in GBq can be varied. Here we present an overview of the development, formulation and optimisation of 177Lu-DOTA-TATE, mainly addressing radiochemical parameters.

  3. Study on the eγ coincidences in the 169Lu decay

    International Nuclear Information System (INIS)

    Batsev, S.; Bonch-Osmolovskaya, N.A.; Budzyak, A.; Kuznetsov, V.V.; Usmanov, R.R.

    1979-01-01

    The 169 Lu→ 169 Yb decay scheme was analyzed on the basis of measurements of eγ coincidence. The 169 Lu sources were obtained by irradiating a tantalum target by 660 MeV protons. The eγ-coincidence spectra were measured by an ironless β-spectrometer with a toroidal magnetic field and a detector. The γ-ray and eγ-coincidence spectra were processed by a computer. The results of processing the 169 Lu coincidence spectra are tabulated. No excited states of 169 Yb not confirmed by γγ and eγ coincidences (except for the head level of the 3/2 + (651) 720 keV band) remain in the 169 Lu decay scheme proposed. Weak transitions with the total intensity of no more than 3.3% per a 169 Lu decay have remained unarranged, they should discharge weakly excited levels of 169 Yb. Probabilities of the 169 Yb level population per a 169 Lu decay and the corresponding values of probabilities of transitions in them are presented. As a whole, the 169 Lu decay scheme involves 60 levels, 31 states of them are new

  4. Progress in the development of LuAlO$_{3}$ based scintillators

    CERN Document Server

    Belsky, A; Lecoq, P; Dujardin, C; Garnier, N; Canibano, H; Pédrini, C; Petrosian, A

    2000-01-01

    LuAlO/sub 3/:Ce/sup 3+/ (LuAP) and Lu/sub x/Y/sub 1/-xAlO/sub 3/:Ce /sup 3+/ (LuYAP) crystals are used as scintillation materials for positron emission tomography. The actual study of these scintillators develops in three directions: (i) growth of large size LuAP crystals with stable properties, (ii) the relationship between the composition of LuYAP crystals and scintillation properties, and (iii) scintillation mechanisms in lutetium compounds. After improving of growth conditions a large size samples (length >40 mm) have been prepared. Crystals show a good correlation between growth parameters, light yield and transmission spectra. We studied a series of samples with calibrated size (2*2*10 mm3) and compare the light yield with standard BGO and LSO samples. Mixed crystals with composition of 0.6

  5. Comparative vectorial efficiency of Lutzomyia evansi and Lu. longipalpis for transmitting Leishmania chagasi.

    Science.gov (United States)

    Montoya-Lerma, J; Cadena, H; Oviedo, M; Ready, P D; Barazarte, R; Travi, B L; Lane, R P

    2003-01-01

    The infection rates and development of Leishmania chagasi in two sandfly species, Lutzomyia evansi and Lutzomyia longipalpis, were evaluated under natural and experimental conditions. Natural infection rates of Lu. evansi in San Andrés de Sotavento (Colombia) and Montañas de Peraza (Venezuela) (0.05 and 0.2%, respectively) were similar to those previously recorded for this species in Colombia and Venezuela and for Lu. longipalpis in many foci of American Visceral Leishmaniasis (AVL). Both sand fly species were able to support the development of two Colombian strains of L. chagasi experimentally acquired from dogs, hamsters or membrane feeders. However, the experimental infection rates and the sequence of parasite development in the guts of these sand flies revealed that parasite colonisation, differentiation, migration and attachment were more frequent and uniform in Lu. longipalpis than in Lu. evansi. This is consistent with a more recent association between L. chagasi and Lu. evansi, and these results might help to explain the irregularity of AVL outbreaks in foci where Lu. evansi has been reported as the sole vector. Copyright 2002 Elsevier Science B.V.

  6. Occupational doses in neuroendocrine tumors by using 177Lu DOTATATE

    International Nuclear Information System (INIS)

    Costa, Gustavo Coelho Alves; Sa, Lidia Vasconcellos de

    2011-01-01

    This paper investigated the treatment of neuroendocrine tumors (abdominal tumors) using of 177 Lu DOTATATE radiopharmaceutical which is a type of treatment presently used in the experimental form in Brazil and, therefore, not contemplated in norms or specific use. This research studied the occupational doses of this treatment and suggested guidelines or rules of procedures viewing the radiological protection of workers involved and the public. The treatment were followed up by using two types of radiation detection, one a scintillator and a Geiger-Muller, and the measurements were performed in a public hospital at Rio de Janeiro and the other in a private hospital at Sao Paulo. It was observed that the equivalent occupational doses can variate from 160 μSv to 450 μSv, in function of operator, of stage of manipulation, and of the administration method, which can be through the use of infusion pump or manual injection. The use of infusion pump is highly recommended and the hospitalization of the patient until the dose rate measured at 1 m does not surpass 20 μSv/h

  7. Single-crystal study of the charge density wave metal LuNiC2

    Science.gov (United States)

    Steiner, S.; Michor, H.; Sologub, O.; Hinterleitner, B.; Höfenstock, F.; Waas, M.; Bauer, E.; Stöger, B.; Babizhetskyy, V.; Levytskyy, V.; Kotur, B.

    2018-05-01

    We report on single-crystal growth, single-crystal x-ray diffraction, physical properties, and density functional theory (DFT) electronic structure as well as Fermi surface calculations for two ternary carbides, LuCoC2 and LuNiC2. Electrical resistivity measurements reveal for LuNiC2 a charge density wave (CDW) transition at TCDW≃450 K and, for T >TCDW , a significant anisotropy of the electrical resistivity, which is lowest along the orthorhombic a axis. The analysis of x-ray superstructure reflections suggest a commensurate CDW state with a Peierls-type distortion of the Ni atom periodicity along the orthorhombic a axis. DFT calculations based on the CDW modulated monoclinic structure model of LuNiC2 as compared to results of the orthorhombic parent type reveal the formation of a partial CDW gap at the Fermi level which reduces the electronic density of states from N (EF)=1.03 states/eV f.u. without CDW to N (EF)=0.46 states/eV f.u. in the CDW state. The corresponding bare DFT Sommerfeld value of the latter, γDFTCDW=0.90 mJ/mol K2, reaches reasonable agreement with the experimental value γ =0.83 (5 ) mJ/mol K2 of LuNiC2. LuCoC2 displays a simple metallic behavior with neither CDW ordering nor superconductivity above 0.4 K. Its experimental Sommerfeld coefficient, γ =5.9 (1) mJ/mol K2, is in realistic correspondence with the calculated, bare Sommerfeld coefficient, γDFT=3.82 mJ/mol K2, of orthorhombic LuCoC2.

  8. Effective lattice stabilization of gadolinium aluminate garnet (GdAG via Lu3+ doping and development of highly efficient (Gd,LuAG:Eu3+ red phosphors

    Directory of Open Access Journals (Sweden)

    Jinkai Li, Ji-Guang Li, Zhongjie Zhang, Xiaoli Wu, Shaohong Liu, Xiaodong Li, Xudong Sun and Yoshio Sakka

    2012-01-01

    Full Text Available The metastable garnet lattice of Gd3Al5O12 is stabilized by doping with smaller Lu3+, which then allows an effective incorporation of larger Eu3+ activators. The [(Gd1−xLux1−yEuy]3Al5O12 (x = 0.1–0.5, y = 0.01–0.09 garnet solid solutions, calcined from their precursors synthesized via carbonate coprecipitation, exhibit strong luminescence at 591 nm (the 5D0 → 7F1 magnetic dipole transition of Eu3+ upon UV excitation into the charge transfer band (CTB at ~239 nm, with CIE chromaticity coordinates of x = 0.620 and y = 0.380 (orange-red. The quenching concentration of Eu3+ was estimated at ~5 at.% (y = 0.05, and the quenching was attributed to exchange interactions. Partial replacement of Gd3+ with Lu3+ up to 50 at.% (x = 0.5 while keeping Eu3+ at the optimal content of 5 at.% does not significantly alter the peak positions of the CTB and 5D0 → 7F1 emission bands but slightly weakens both bands owing to the higher electronegativity of Lu3+. The effects of processing temperature (1000–1500 °C and Lu/Eu contents on the intensity, quantum efficiency, lifetime and asymmetry factor of luminescence were thoroughly investigated. The [(Gd0.7Lu0.30.95Eu0.05]3Al5O12 phosphor processed at 1500 °C exhibits a high internal quantum efficiency of ~83.2% under 239 nm excitation, which, in combination with the high theoretical density, favors its use as a new type of photoluminescent and scintillation material.

  9. Preparation of 177Lu-DOTA/DTPA-Bz-Cys-RGD dimer and biodistribution evaluation in normal mice

    International Nuclear Information System (INIS)

    Sheng Feng; Jia Bing; Wang Fan; He Weiwei; Liu Zhaofei; Zhao Huiyun

    2008-01-01

    177 Lu-DOTA-Bz-Cys-RGD dimer and 177 Lu-DTPA-Bz-Cys-RGD dimer were prepared, and the in vitro and in vivo properties were compared. TLC and HPLC show that the labeling yields of two radiolabeled compounds are more than 95% under optimal conditions (pH=5.0, reacting at 100 degree C for 15-20 min), and the two radiolabeled compounds show pretty good in vitro stability. HPLC analyses and lg P values reveal that lipophilicity of 177 Lu-DOTA-Bz-Cys- RGD dimer is higher than 177 Lu-DTPA-Bz-Cys-RGD dimer. The uptake of 177 Lu-DTPA-Bz-Cys- RGD dimer in other tissues is significantly higher than that of 177 Lu-DOTA-Bz-Cys-RGD dimer at 4 h postinjection, except for blood and spleen. The in vivo stability of 177 Lu-DOTA-Bz-Cys-RGD dimer is much better than 177 Lu-DTPA-Bz-Cys-RGD dimer. Bz-DOTA is an ideal bifunctional chelator for 177 Lu labeling of RGD dimer. (authors)

  10. Preparation of LuAG Powders with Single Phase and Good Dispersion for Transparent Ceramics Using Co-Precipitation Method

    Science.gov (United States)

    Pan, Liangjie; Jiang, Benxue; Fan, Jintai; Yang, Qiuhong; Zhou, Chunlin; Zhang, Pande; Mao, Xiaojian; Zhang, Long

    2015-01-01

    The synthesis of pure and well dispersed lutetium aluminum garnet (LuAG) powder is crucial and important for the preparation of LuAG transparent ceramics. In this paper, high purity and well dispersed LuAG powders have been synthesized via co-precipitation method with lutetium nitrate and aluminum nitrate as raw materials. Ammonium hydrogen carbonate (AHC) was used as the precipitant. The influence of aging time, pH value, and dripping speed on the prepared LuAG powders were investigated. It showed that long aging duration (>15 h) with high terminal pH value (>7.80) resulted in segregation of rhombus Lu precipitate and Al precipitate. By decreasing the initial pH value or accelerating the dripping speed, rhombus Lu precipitate was eliminated and pure LuAG nano powders were synthesized. High quality LuAG transparent ceramics with transmission >75% at 1064 nm were fabricated using these well dispersed nano LuAG powders. PMID:28793510

  11. Preparation of LuAG Powders with Single Phase and Good Dispersion for Transparent Ceramics Using Co-Precipitation Method

    Directory of Open Access Journals (Sweden)

    Liangjie Pan

    2015-08-01

    Full Text Available The synthesis of pure and well dispersed lutetium aluminum garnet (LuAG powder is crucial and important for the preparation of LuAG transparent ceramics. In this paper, high purity and well dispersed LuAG powders have been synthesized via co-precipitation method with lutetium nitrate and aluminum nitrate as raw materials. Ammonium hydrogen carbonate (AHC was used as the precipitant. The influence of aging time, pH value, and dripping speed on the prepared LuAG powders were investigated. It showed that long aging duration (>15 h with high terminal pH value (>7.80 resulted in segregation of rhombus Lu precipitate and Al precipitate. By decreasing the initial pH value or accelerating the dripping speed, rhombus Lu precipitate was eliminated and pure LuAG nano powders were synthesized. High quality LuAG transparent ceramics with transmission >75% at 1064 nm were fabricated using these well dispersed nano LuAG powders.

  12. Stem cell plasticity.

    Science.gov (United States)

    Lakshmipathy, Uma; Verfaillie, Catherine

    2005-01-01

    The central dogma in stem cell biology has been that cells isolated from a particular tissue can renew and differentiate into lineages of the tissue it resides in. Several studies have challenged this idea by demonstrating that tissue specific cell have considerable plasticity and can cross-lineage restriction boundary and give rise to cell types of other lineages. However, the lack of a clear definition for plasticity has led to confusion with several reports failing to demonstrate that a single cell can indeed differentiate into multiple lineages at significant levels. Further, differences between results obtained in different labs has cast doubt on some results and several studies still await independent confirmation. In this review, we critically evaluate studies that report stem cell plasticity using three rigid criteria to define stem cell plasticity; differentiation of a single cell into multiple cell lineages, functionality of differentiated cells in vitro and in vivo, robust and persistent engraft of transplanted cells.

  13. Plastics and environment

    International Nuclear Information System (INIS)

    Avenas, P.

    1996-01-01

    Synthetic organic polymers, such as plastics, PVC, polyamides etc are considered less ecological than natural materials such as wood. Other artificial materials such as metals, glass or biodegradable plastics have also a better image than petroleum products. This short paper demonstrates that the manufacturing or the transport of every material uses energy and that the complete energy balance sheet of a plastic bottle, for instance, is more favourable than the one of a glass bottle. Plastic materials are also easily valorized and recycled and part of the energy spent during manufacturing can be recovered during incineration for district heating. During the life-cycle of such a synthetic material, the same petroleum quantity can be used twice which leads to less negative effects on the environment. Finally, the paper focusses on the problem of biodegradable materials which are not degradable when buried under several meters of wastes and which are a nuisance to recycling. (J.S.)

  14. Plastics: Friend or foe?

    Directory of Open Access Journals (Sweden)

    O P Gupta

    2018-01-01

    Full Text Available Plastics has been playing a very significant role in our life. Being light weight, inexpensive and heving good insulating properties it is being used in all aspects of life, from clothes to contact lenses and from mobile phones to automobiles as well as in medical equipments, However it is not biodegradable, and while degrading to fragments it gets converted in to microplastics and nanoplastics The plastic waste is being recognized as an environmental hazard, since these micr- and nanoplastics find way from landfills to water and foods, It is said that we are not only using, but we are eating, drinking and even braething the plastics. These microplastics in body release certain hazardous chemicals and found to be disrupting functions of certain endocrine organs. Whether the rising prevalence of Diabetes, thyroid disorders or infirtility etc., are realated to the plastics?

  15. Recycling of plastics

    Energy Technology Data Exchange (ETDEWEB)

    Kaminsky, W; Menzel, J; Sinn, H

    1976-01-01

    Considering the shortage of raw materials and environmental pollution, the recycling of plastic waste is a very important topic. Pilot plants for research in Funabashi Japan, Franklin (Ohio) U.S.A., and the R 80-process of Krauss Maffei, W. Germany, have demonstrated the possibility of reclaiming plastics from refuse. Old tires and waste from the plastic producing and manufacturing industries are readily available. The pyrolysis of plastic yields gaseous and liquid products, and the exploitation of this cracking reaction has been demonstrated by pilot plants in Japan and Great Britain. Further laboratory scale experiments are taking place in W. Germany. In continuous fluidized beds and in molten salts, polyethylene, polypropylene, polyvinylchloride, polystyrene and rubber are pyrolysed and better than 98 percent conversion is obtained. Up to 40 percent of the feed can be obtained as aromatic compounds, and a pilot plant is under construction. As a first step PVC-containing material can be almost quantitatively dehydrochlorinated.

  16. A Plastic Menagerie

    Science.gov (United States)

    Hadley, Mary Jane

    2010-01-01

    Bobble heads had become quite popular, depicting all sorts of sports figures, animals, and even presidents. In this article, the author describes how her fourth graders made bobble head sculptures out of empty plastic drink bottles. (Contains 1 online resource.)

  17. Art and Plastic Surgery.

    Science.gov (United States)

    Fernandes, Julio Wilson; Metka, Susanne

    2016-04-01

    The roots of science and art of plastic surgery are very antique. Anatomy, drawing, painting, and sculpting have been very important to the surgery and medicine development over the centuries. Artistic skills besides shape, volume, and lines perception can be a practical aid to the plastic surgeons' daily work. An overview about the interactions between art and plastic surgery is presented, with a few applications to rhinoplasty, cleft lip, and other reconstructive plastic surgeries. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

  18. Radiolabeling parameters of {sup 177}Lu-DOTA-RITUXIMAB

    Energy Technology Data Exchange (ETDEWEB)

    Massicano, Adriana V.F.; Alcarde, Lais F.; Oliveira, Ricardo S.; Mengatti, Jair; Araujo, Elaine B. de, E-mail: adriana.avfernandes@gmail.com [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    Cancer treatment using radioimmunotherapy (RIT) has been the focus of much research in the last two decades. In RIT, a radioisotope is coupled to a monoclonal antibody (mAb) to form a tumor-specific target agent to improve the cytocidal effect of the mAbs. RIT allows the systemic delivery of radiation to disease target by mAbs while sparing normal tissues. Rituximab® (Mabthera - Roche) is a chimeric mouse-human monoclonal antibody; it selectively binds with high affinity to the CD20 antigen, a hydrophobic transmembrane protein, which is expressed on B-lymphocytes and in more than 90% of B cell non-Hodgkin's lymphomas (NHL). The conjugation and radiolabeling process involve special conditions of pH and temperature, long processes of manipulation and mixing. All this process can damage the antibody structure and compromise its clinical application. Therefore, these parameters must be largely studied. The aim of this work was to evaluate the best radiolabeling conditions of DOTA-rituximab. Briefly, 10 mg of antibody previously purified by ultrafiltration device was conjugated with DOTA-NHS-ester (Macrocyclics) in 50 fold molar excess. The reaction was conducted for 1 hour in phosphate buffer pH 8.0 and gently mixing at room temperature, remaining for 24 hours under refrigeration. The immunoconjugated was purified by size exclusion column and ultrafiltration device. The radiolabeled parameters studied were: immunoconjugated mass, activity of {sup 177}LuCl{sub 3}, reaction time, temperature and pH. The radiochemical purity of the preparations was determined using analysis by thin layer chromatography (TLC-SG plates). The best studied condition presented radiochemical purity above 95% and the integrity of antibody was preserved. (author)

  19. Radiolabeling parameters of 177Lu-DOTA-RITUXIMAB

    International Nuclear Information System (INIS)

    Massicano, Adriana V.F.; Alcarde, Lais F.; Oliveira, Ricardo S.; Mengatti, Jair; Araujo, Elaine B. de

    2013-01-01

    Cancer treatment using radioimmunotherapy (RIT) has been the focus of much research in the last two decades. In RIT, a radioisotope is coupled to a monoclonal antibody (mAb) to form a tumor-specific target agent to improve the cytocidal effect of the mAbs. RIT allows the systemic delivery of radiation to disease target by mAbs while sparing normal tissues. Rituximab® (Mabthera - Roche) is a chimeric mouse-human monoclonal antibody; it selectively binds with high affinity to the CD20 antigen, a hydrophobic transmembrane protein, which is expressed on B-lymphocytes and in more than 90% of B cell non-Hodgkin's lymphomas (NHL). The conjugation and radiolabeling process involve special conditions of pH and temperature, long processes of manipulation and mixing. All this process can damage the antibody structure and compromise its clinical application. Therefore, these parameters must be largely studied. The aim of this work was to evaluate the best radiolabeling conditions of DOTA-rituximab. Briefly, 10 mg of antibody previously purified by ultrafiltration device was conjugated with DOTA-NHS-ester (Macrocyclics) in 50 fold molar excess. The reaction was conducted for 1 hour in phosphate buffer pH 8.0 and gently mixing at room temperature, remaining for 24 hours under refrigeration. The immunoconjugated was purified by size exclusion column and ultrafiltration device. The radiolabeled parameters studied were: immunoconjugated mass, activity of 177 LuCl 3 , reaction time, temperature and pH. The radiochemical purity of the preparations was determined using analysis by thin layer chromatography (TLC-SG plates). The best studied condition presented radiochemical purity above 95% and the integrity of antibody was preserved. (author)

  20. DEVELOPMENT OF PLASTIC SURGERY.

    Science.gov (United States)

    Pećanac, Marija Đ

    2015-01-01

    Plastic surgery is a medical specialty dealing with corrections of defects, improvements in appearance and restoration of lost function. Ancient times. The first recorded account of reconstructive plastic surgery was found in ancient Indian Sanskrit texts, which described reconstructive surgeries of the nose and ears. In ancient Greece and Rome, many medicine men performed simple plastic cosmetic surgeries to repair damaged parts of the body caused by war mutilation, punishment or humiliation. In the Middle Ages, the development of all medical braches, including plastic surgery was hindered. New age. The interest in surgical reconstruction of mutilated body parts was renewed in the XVIII century by a great number of enthusiastic and charismatic surgeons, who mastered surgical disciplines and became true artists that created new forms. Modern era. In the XX century, plastic surgery developed as a modern branch in medicine including many types of reconstructive surgery, hand, head and neck surgery, microsurgery and replantation, treatment of burns and their sequelae, and esthetic surgery. Contemporary and future plastic surgery will continue to evolve and improve with regenerative medicine and tissue engineering resulting in a lot of benefits to be gained by patients in reconstruction after body trauma, oncology amputation, and for congenital disfigurement and dysfunction.

  1. Recycling of packing plastics

    International Nuclear Information System (INIS)

    Gintenreiter-Koegl, S.

    2001-05-01

    The ordinance on the avoidance of packaging waste was a serious intervention in the public and private waste management in Austria. Above all the high expenses for an overall packaging waste collection and the recycling of packaging plastics were criticized. The landfill ordinance comes into force in 2004 and this means another major change in the Austrian waste management system. In the course of this change the overall collection and the recycling and recovery of waste streams, especially of the high caloric plastics waste, have to be discussed again. The goal of this work was on the one hand to develop and adapt the hydrocracking process for the recovery of mixed plastics waste and to show a possible application in Austria. On the other hand the work shows the technical, ecological and economical conditions for packaging plastics recycling and recovery in order to find optimum applications for the processes and to examine their contribution to a sustainable development. A hydrocracking test plant for the processing of mixed plastic wastes was built and had been running for about three years. The tests were carried out successfully and the suitability of the technology for the recovery of packaging plastics could be shown. Results show at least a 35 % yield of fuel. The hydrocracking technology is quite common in the oil industries and therefore an integration on a refinery site is suggested. (author)

  2. Targeting angiogenesis for radioimmunotherapy with a {sup 177}Lu-labeled antibody

    Energy Technology Data Exchange (ETDEWEB)

    Ehlerding, Emily B.; Hernandez, Reinier [University of Wisconsin - Madison, Department of Medical Physics, Madison, WI (United States); Lacognata, Saige; Jiang, Dawei [University of Wisconsin - Madison, Department of Radiology, Madison, WI (United States); Ferreira, Carolina A. [University of Wisconsin - Madison, Department of Biomedical Engineering, Madison, WI (United States); Goel, Shreya [University of Wisconsin - Madison, Department of Materials Science and Engineering, Madison, WI (United States); Jeffery, Justin J. [University of Wisconsin - Madison, Small Animal Imaging Facility, Madison, WI (United States); Theuer, Charles P. [TRACON Pharmaceuticals, Inc., San Diego, CA (United States); Cai, Weibo [University of Wisconsin - Madison, Department of Medical Physics, Madison, WI (United States); University of Wisconsin - Madison, Department of Radiology, Madison, WI (United States); University of Wisconsin - Madison, Department of Biomedical Engineering, Madison, WI (United States); University of Wisconsin - Madison, Department of Materials Science and Engineering, Madison, WI (United States)

    2018-01-15

    Increased angiogenesis is a marker of aggressiveness in many cancers. Targeted radionuclide therapy of these cancers with angiogenesis-targeting agents may curtail this increased blood vessel formation and slow the growth of tumors, both primary and metastatic. CD105, or endoglin, has a primary role in angiogenesis in a number of cancers, making this a widely applicable target for targeted radioimmunotherapy. The anti-CD105 antibody, TRC105 (TRACON Pharmaceuticals), was conjugated with DTPA for radiolabeling with {sup 177}Lu (t{sub 1/2} 6.65 days). Balb/c mice were implanted with 4T1 mammary carcinoma cells, and five study groups were used: {sup 177}Lu only, TRC105 only, {sup 177}Lu-DTPA-IgG (a nonspecific antibody), {sup 177}Lu-DTPA-TRC105 low-dose, and {sup 177}Lu-DTPA-TRC105 high-dose. Toxicity of the agent was monitored by body weight measurements and analysis of blood markers. Biodistribution studies of {sup 177}Lu-DTPA-TRC105 were also performed at 1 and 7 days after injection. Ex vivo histology studies of various tissues were conducted at 1, 7, and 30 days after injection of high-dose {sup 177}Lu-DTPA-TRC105. Biodistribution studies indicated steady uptake of {sup 177}Lu-DTPA-TRC105 in 4T1 tumors between 1 and 7 days after injection (14.3 ± 2.3%ID/g and 11.6 ± 6.1%ID/g, respectively; n = 3) and gradual clearance from other organs. Significant inhibition of tumor growth was observed in the high-dose group, with a corresponding significant increase in survival (p < 0.001, all groups). In most study groups (all except the nonspecific IgG group), the body weights of the mice did not decrease by more than 10%, indicating the safety of the injected agents. Serum alanine transaminase levels remained nearly constant indicating no damage to the liver (a primary clearance organ of the agent), and this was confirmed by ex vivo histological analyses. {sup 177}Lu-DTPA-TRC105, when administered at a sufficient dose, is able to curtail tumor growth and provide a

  3. Emergence and present status of Lu-177 in targeted radiotherapy. The Indian scenario

    Energy Technology Data Exchange (ETDEWEB)

    Banerjee, S.; Das, T.; Chakraborty, S.; Venkatesh, M. [Bhabha Atomic Reseach Centre, Trombay, Mumbai (India). Radiopharmaceuticals Div.

    2012-07-01

    {sup 177}Lu is presently considered to be a potential radionuclide for the development of agents for radionuclide therapy owing to its favorable nuclear decay characteristics [T{sub 1/2} = 6.65 d, E{sub {beta}}{sub (max)} = 0.497 MeV, E{sub {gamma}} = 113 KeV (6.4%) and 208 KeV (11%)]. While the long half-life of this promising radioisotope offers distinct logistic advantage, particularly, in countries having limited reactor facilities, the feasibility of its large-scale production with adequate specific activity and excellent radionuclidic purity in medium flux research reactors constitute yet another desirable feature. Extensive studies have been carried out to optimize the production of this isotope, with high specific activity and radionuclidic purity by the (n,{gamma}) route using the highest available flux and the optimum irradiation time. The gradual evolution of clin ical grade {sup 177}LuCl{sub 3} as a new radiochemical, ready for commercial deployment by Radiopharmaceuticals Division, Bhabha Atomic Research Centre, to nuclear medicine centers all over India was accomplished in 2010 in a stepwise manner with the commencement of the production of high specific activity {sup 177}Lu from enriched target in 2001. Research on {sup 177}Lu has demonstrated its immense potential in radiotherapeutic applications, a direct outcome of which has resulted in indigenous development of two agents viz. {sup 177}Lu-EDTMP and {sup 177}Lu-DOTA-TATE presently being evaluated in human patients for palliative care of bone pain due to skeletal metastases and treatment of malignancies of neuroendocrine origin, respectively. Using locally produced {sup 177}Lu, the radiolabeling of a plethora of other molecules with potential applicability in radiation synovectomy and targeted therapy of malignant tumors have been successfully demonstrated. A few of these agent such as a novel {sup 177}Lu-labeled porphyrin has shown considerable promise in initial studies and is presently evaluated

  4. Absence of justice : Lu Chengming's struggle for compensation

    Energy Technology Data Exchange (ETDEWEB)

    Bai, L.

    2008-03-10

    This article described the efforts of Chinese citizen Lu Chengming to claim compensation from the Chinese government after being forcibly re-located during the building of the Three Gorges hydroelectric project. Research conducted by the author revealed that many households were not compensated for being resettled, and that many people who had lived in the region became refugees. Lu Chengming's family became unemployed after his hotel was demolished in 2002. The family of 11 was then divided into 4 in order to further reduce the amount of subsidies owed to them. Appeals to higher authorities began in 1993. Since then, Lu Chengming has only received the most basic welfare assistance. This article provided a translation of Lu Chengming's testimony as well as his account of the resettlement procedures. It was concluded that while the Chinese government consistently refuses his claims, Lu Chengming continues to live in hope that the government will award him his settlement. 4 refs., 3 figs.

  5. 2-micron lasing in Tm:Lu2O3 ceramic: initial operation

    Science.gov (United States)

    Vetrovec, John; Filgas, David M.; Smith, Carey A.; Copeland, Drew A.; Litt, Amardeep S.; Briscoe, Eldridge; Schirmer, Ernestina

    2018-03-01

    We report on initial lasing of Tm:Lu2O3 ceramic laser with tunable output in the vicinity of 2 μm. Tm:Lu2O3 ceramic gain materials offer a much lower saturation fluence than the traditionally used Tm:YLF and Tm:YAG materials. The gain element is pumped by 796 nm diodes via a "2-for-1" crossrelaxation energy transfer mechanism, which enables high efficiency. The high thermal conductivity of the Lu2O3 host ( 18% higher than YAG) in combination with low quantum defect of 20% supports operation at high-average power. Konoshima's ceramic fabrication process overcomes the scalability limits of single crystal sesquioxides. Tm:Lu2O3 offers wide-bandwidth amplification of ultrashort pulses in a chirped-pulse amplification (CPA) system. A laser oscillator was continuously tuned over a 230 nm range from 1890 to 2120 nm while delivering up to 43W QCW output with up to 37% efficiency. This device is intended for initial testing and later seeding of a multi-pass edge-pumped disk amplifier now being developed by Aqwest which uses composite Tm:Lu2O3 disk gain elements.

  6. Progress in the development of LuAlO3 based scintillators

    CERN Document Server

    Belsky, A; Lecoq, P; Dujardin, C; Garnier, N; Canibano, H; Pédrini, C; Petrosian, A

    2000-01-01

    LuAlO3:Ce3+ (LuAP) and LuxY1-xAlO3:Ce3+ (LuYAP) crystals are the promote scintillation materials for Positron Emission Tomography. Actual study of these scintillators develops in the tree directions: (i) growth of large size LuAP crystals with stable properties, (ii) relationship between composition of LuYAP crystals and scintillation properties, and (iii) scintillation mechanisms in lutetium compounds. After improving of growth conditions a large size samples (length greater than 40 mm) have been prepared. Crystals show a good correlation between growth parameters, light yield and transmission spectra. We performed a series of samples with calibrated size (2x2x10 mm3) and compare the light yield with a standard BGO and LSO samples. Mixed crystals with composition of 0.6 less than x less than 0.8 show a significant increase of light yield. We suggest that the short order clusterisation in mixed crystals may by playing an important role in governing the scintillation efficiency. In order to clarify the scintil...

  7. Crystal growth and luminescence properties of Pr-doped LuLiF4 single crystal

    International Nuclear Information System (INIS)

    Sugiyama, Makoto; Yanagida, Takayuki; Yokota, Yuui; Kurosawa, Shunsuke; Fujimoto, Yutaka; Yoshikawa, Akira

    2013-01-01

    0.1, 1, and 3% Pr (with respect to Lu) doped LuLiF 4 (Pr:LuLiF 4 ) single crystals were grown by the micro-pulling-down (μ-PD) method. Transparency of the grown crystals was higher than 70% in the visible wavelength region with some absorption bands due to Pr 3+ 4f-4f transitions. Intense absorption bands related with the Pr 3+ 4f-5d transitions were observed at 190 and 215 nm. In radioluminescence spectra, Pr 3+ 5d-4f emissions were observed at 220, 240, 340, and 405 nm. In the pulse height spectra recorded under 137 Cs γ-ray excitation, the Pr 3% doped sample showed the highest light yield of 2050 photons/MeV and the scintillation decay time of it exhibited 23 and 72 ns also excited by 137 Cs γ-ray. -- Highlights: ► 0.1, 1, and 3% Pr-doped LuLiF 4 single crystals were grown by the μ-PD method. ► Pr 3+ 5d-4f emission peaks appeared at 220, 240, 340, and 405 nm ► The Pr 3%:LuLiF 4 crystal showed the highest light yield of 2050 photons/MeV

  8. Study on preparation of 17'7Lu, labeling with DOTATATE for using in diagnosis and treatment neuroendocrine tumors

    International Nuclear Information System (INIS)

    Duong Van Dong; Bui Van Cuong; Pham Ngoc Dien; Chu Van Khoa; Mai Phuoc Tho; Nguyen Thi Thu; Vo Thi Cam Hoa

    2014-01-01

    Due to its physical and chemical characteristics, 177 Lu is a very attractive radionuclide for use in nuclear medicine. Its main usage is in the treatment of neuroendocrine tumours but its applicability in the treatment of colon cancer, metastatic bone cancer, non-Hodgkin lymphoma, lung, ovarian, and prostate cancer, has also been studied. Two alternative production routes are generally applied to obtain 177 Lu, namely the direct route based on neutron irradiation of lutetium targets and the indirect route based on neutron irradiation of ytterbium targets followed by radiochemical separation of 177 Lu from ytterbium isotopes. The comparison of theoretically calculated and experimentally determined yield for 176 Lu(n,γ) 177 Lu reaction is presented. 177 Lu could be produced with a specific activity of 42 mCi/mg by neutron activation using enriched 176 Lu (2.59%) target when irradiation was carried out at Dalat Nuclear Research Reactor with thermal neutron flux of 2x10 13 n.cm -2 .s -1 for 100 hours. The indirect production route as an alternative production route, 177 Lu could be obtained as carrier-free from beta decay of 177 Yb produced by neutron activation of 176 Yb. In this way, enriched target material was used but it may be the neutron capture cross section is only 2.4 barn so resulting in low activity just enough to study the separation process of 177 Lu from 177 Yb. In the other hand the study on labeling 177 Lu with DOTATATE is also described the optimization of the reaction conditions to obtain the complex 177 Lu-DOTATATE with a radiochemical purity > 99%, even so the studies of stability in vitro to the dilution in saline solution during 72 hours. The bio-distribution studies of this product in mice and rabbit are also investigated. (author)

  9. A Conservative Formulation for Plasticity

    Science.gov (United States)

    1992-01-01

    concepts that apply to a broad class of macroscopic models: plastic deformation and plastic flow rule. CONSERVATIVE PLASTICITY 469 3a. Plastic Defrrnation...temperature. We illustrate these concepts with a model that has been used to describe high strain-rate plastic flow in metals [11, 31, 32]. In the case...JOURDREN, AND P. VEYSSEYRE. Un Modele ttyperelastique- Plastique Euldrien Applicable aux Grandes Dtformations: Que/ques R~sultats 1-D. preprint, 1991. 2. P

  10. Analysis of the spectrum of four-times-ionized lutetium (Lu V)

    International Nuclear Information System (INIS)

    Kaufman, V.; Sugar, J.

    1978-01-01

    Spectra of Lu obtained with a sliding spark discharge at peak currents of 50--500 A were recorded with a 10.7 m normal incidence spectrograph in the range of 500--2100 A. Intercomparison of spectra revealed a distinct separation of Lu III, IV, and V, the first two of which have already been anlayzed. The present work contains an interpretation of Lu V in which 419 lines are classified as transitions among 136 energy levels of the 4f 13 , 4f 12 5d, 4f 12 6s, and 4f 12 6p configurations. Calculated energy levels and eigenvectors, obtained with fitted values for the radial integrals, are given

  11. High speed corner and gap-seal computations using an LU-SGS scheme

    Science.gov (United States)

    Coirier, William J.

    1989-01-01

    The hybrid Lower-Upper Symmetric Gauss-Seidel (LU-SGS) algorithm was added to a widely used series of 2D/3D Euler/Navier-Stokes solvers and was demonstrated for a particular class of high-speed flows. A limited study was conducted to compare the hybrid LU-SGS for approximate Newton iteration and diagonalized Beam-Warming (DBW) schemes on a work and convergence history basis. The hybrid LU-SGS algorithm is more efficient and easier to implement than the DBW scheme originally present in the code for the cases considered. The code was validated for the hypersonic flow through two mutually perpendicular flat plates and then used to investigate the flow field in and around a simplified scramjet module gap seal configuration. Due to the similarities, the gap seal flow was compared to hypersonic corner flow at the same freestream conditions and Reynolds number.

  12. Toxicity of trastuzumab labeled {sup 177}Lu on MCF7 and SKBr3 cell lines

    Energy Technology Data Exchange (ETDEWEB)

    Rasaneh, Samira [Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box 14115-331, Tehran (Iran, Islamic Republic of); Rajabi, Hossein, E-mail: hrajabi@modares.ac.i [Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box 14115-331, Tehran (Iran, Islamic Republic of); Hossein Babaei, Mohammad; Johari Daha, Fariba [Department of Radioisotope, Nuclear Science and Technology Research Institute, Tehran (Iran, Islamic Republic of)

    2010-10-15

    In this study, we labeled trastuzumab with {sup 177}Lu to synthesize a new radiopharmaceutical for therapy of breast cancer and at the first stage investigated its therapeutic effects on SKBr3 and MCF7 breast cancer cell lines. Trastuzumab-{sup 177}Lu showed very good in-vitro characteristics such as high radiochemical purity (91{+-}0.9%), good stability in PBS buffer (86{+-}2.3%) and blood serum (81{+-}2.7%) up to 96 h, appropriate immunoreactivity (85.4{+-}1.1%) and high cytotoxicity in HER2 expression cells. 5 fold increase in toxicity of trastuzumab-{sup 177}Lu was observed when compared with unlabeled trastuzumab on SKBr3 cells.

  13. Scintillation properties of a La, Lu-admix gadolinium pyrosilicate crystal

    Energy Technology Data Exchange (ETDEWEB)

    Kurosawa, Shunsuke, E-mail: kurosawa@imr.tohoku.ac.jp [Institute for Materials Research (IMR), Tohoku University 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577 (Japan); New Industry Creation Hatchery Center (NICHe) 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8579 (Japan); Shishido, Toetsu; Suzuki, Akira; Sugawara, Takamasa; Nomura, Akiko; Yubuta, Kunio [Institute for Materials Research (IMR), Tohoku University 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577 (Japan); Shoji, Yasuhiro [Institute for Materials Research (IMR), Tohoku University 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577 (Japan); C& A Corporation, 6-6-40 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8577 (Japan); Yokota, Yuui [New Industry Creation Hatchery Center (NICHe) 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8579 (Japan); Pejchal, Jan [New Industry Creation Hatchery Center (NICHe) 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8579 (Japan); Institute of Physics, AS CR, Cukrovarnická 10, 162 53 Prague (Czech Republic); Ohashi, Yuji [Institute for Materials Research (IMR), Tohoku University 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577 (Japan); Kamada, Kei [New Industry Creation Hatchery Center (NICHe) 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8579 (Japan); C& A Corporation, 6-6-40 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8577 (Japan); Yoshikawa, Akira [Institute for Materials Research (IMR), Tohoku University 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577 (Japan); New Industry Creation Hatchery Center (NICHe) 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8579 (Japan); C& A Corporation, 6-6-40 Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8577 (Japan)

    2015-06-01

    In order to obtain new scintillator with higher effective atomic number, a pyrosilicate crystal with a composition (Ce{sub 0.01}, Gd{sub 0.54}, La{sub 0.25}, Lu{sub 0.20}){sub 2}Si{sub 2}O{sub 7} (Ce:LaLu-GPS) was grown by the floating zone method. Emission wavelengths of this material were at 370 and 390 nm. Gamma-ray-excited pulse height and scintillation decay measurement showed that Ce:LaLu-GPS had a light output of 34,000±2000 photons/MeV, an FWHM energy resolution of 6.9±0.2%, and the decay time components of 59±1 ns (13%) and 570±20 ns (87%)

  14. The plasticity of clays

    Science.gov (United States)

    Group, F.F.

    1905-01-01

    (1) Sand injures plasticity little at first because the grains are suspended in a plastic mass. It is only when grains are abundant enough to come in contact with their neighbors, that the effect becomes serious, and then both strength and amount of possible flow are injured. (2) Certain rare organic colloids increase the plasticity by rendering the water viscous. (3) Fineness also tends to increase plasticity. (4) Plane surfaces (plates) increase the amount of possible flow. They also give a chance for lubrication by thinner films, thus increasing the friction of film, and the strength of the whole mass. The action of plates is thus twofold ; but fineness may be carried to such an extent as to break up plate-like grains into angular fragments. The beneficial effects of plates are also decreased by the fact that each is so closely surrounded by others in the mass. (5) Molecular attraction is twofold in increasing plasticity. As the attraction increases, the coherence and strength of the mass increase, and the amount of possible deformation before crumbling also increases. Fineness increases this action by requiring more water. Colloids and crystalloids in solution may also increase the attraction. It is thus seen to be more active than any other single factor.

  15. Plastics control paraffin buildup

    Energy Technology Data Exchange (ETDEWEB)

    1965-06-01

    Paraffin buildup in producing oil wells has been virtually eliminated by the use of plastic-coated sucker rods. The payout of the plasticing process is generally reached in less than a year, and the paraffin buildup may be inhibited for 10 yr or longer. Most of the plants applying plastic coatings to sucker rods are now fully automated, though a few still offer the hand-sprayed coating that some operators prefer. The several steps involved are described. The ideal plastic for the job is resistant to chemicals at high and low temperatures, flexible, has good adhesion, abrasion resistance, impact resistance, and a smooth glossy finish. The phenol aldehyde and epoxy resins presently offered by the industry fulfill these specifications very well; the multicoating and multibaking techniques improve their performance. Due to wide variations in the severity of the paraffin problem from one oil field to another, there is no general rule to estimate the possible savings from using plastic-coated sucker rods. The process, however, does appear to do a remarkable job in controlling paraffin buildup wherever it is a problem in producing oil by pump.

  16. Lu{sub 2}O{sub 3}:Tb,Hf storage phosphor

    Energy Technology Data Exchange (ETDEWEB)

    Kulesza, Dagmara; Trojan-Piegza, Joanna [Faculty of Chemistry, University of Wroclaw, 14 F. Joliot-Curie Street, 50-383 Wroclaw (Poland); Zych, Eugeniusz, E-mail: zych@wchuwr.p [Faculty of Chemistry, University of Wroclaw, 14 F. Joliot-Curie Street, 50-383 Wroclaw (Poland)

    2010-03-15

    Lu{sub 2}O{sub 3}:Tb,Hf ceramics containing 0.1% of Tb and 0-1.5% of Hf were prepared in reducing atmosphere at 1700 {sup o}C and their thermoluminescence properties were systematically studied. For comparison Tb,Ca co-doped specimen was also fabricated and investigated. The Tb,Hf ceramics shows basically a single TL band located around 180 {sup o}C as found with heating rate of 15 {sup o}C/min. Ceramics singly doped with Tb show complex TL glow curves indicating the presence of traps of very different depths. On the other hand Tb,Ca co-doping is beneficial for the development of shallow traps with the main TL band around 70 {sup o}C. Hence, the aliovalent impurities, Ca{sup 2+} and Hf{sup 4+}, strongly influenced the traps structure in Lu{sub 2}O{sub 3}:Tb ceramics, each of them in its own specific way. Isothermal decay of Lu{sub 2}O{sub 3}:Tb,Hf at 185 {sup o}C was recorded and its shape suggest that multiple hole trapping occurs in the Lu{sub 2}O{sub 3}:Tb,Hf ceramics. Due to the different traps depths the Lu{sub 2}O{sub 3}:Tb,Hf ceramics possess properties typical for storage phosphors, while Lu{sub 2}O{sub 3}:Tb,Ca is a persistent luminescent material rather.

  17. Effects of Lu and Tm Doping on Thermoelectric Properties of Bi2Te3 Compound

    Science.gov (United States)

    Yaprintsev, Maxim; Lyubushkin, Roman; Soklakova, Oxana; Ivanov, Oleg

    2018-02-01

    The Bi2Te3, Bi1.9Lu0.1Te3 and Bi1.9Tm0.1Te3 thermoelectrics of n-type conductivity have been prepared by the microwave-solvothermal method and spark plasma sintering. These compounds behave as degenerate semiconductors from room temperature up to temperature T d ≈ 470 K. Within this temperature range the temperature behavior of the specific electrical resistivity is due to the temperature changes of electron mobility determined by acoustic and optical phonon scattering. Above T d, an onset of intrinsic conductivity takes place when electrons and holes are present. At the Lu and Tm doping, the Seebeck coefficient increases, while the specific electrical resistivity and total thermal conductivity decrease within the temperature 290-630 K range. The increase of the electrical resistivity is related to the increase of electron concentration since the Tm and Lu atoms are donor centres in the Bi2Te3 lattice. The increase of the density-of-state effective mass for conduction band can be responsible for the increase of the Seebeck coefficient. The decrease of the total thermal conductivity in doped Bi2Te3 is attributed to point defects like the antisite defects and Lu or Tm atoms substituting for the Bi sites. In addition, reducing the electron thermal conductivity due to forming a narrow impurity (Lu or Tm) band having high and sharp density-of-states near the Fermi level can effectively decrease the total thermal conductivity. The thermoelectric figure-of-merit is enhanced from ˜ 0.4 for undoped Bi2Te3 up to ˜ 0.7 for Bi1.9Tm0.1Te3 and ˜ 0.9 for Bi1.9Lu0.1Te3.

  18. Water-stable NaLuF4-based upconversion nanophosphors with long-term validity for multimodal lymphatic imaging.

    Science.gov (United States)

    Zhou, Jing; Zhu, Xingjun; Chen, Min; Sun, Yun; Li, Fuyou

    2012-09-01

    Multimodal imaging is rapidly becoming an important tool for biomedical applications because it can compensate for the deficiencies of individual imaging modalities. Herein, multifunctional NaLuF(4)-based upconversion nanoparticles (Lu-UCNPs) were synthesized though a facile one-step microemulsion method under ambient condition. The doping of lanthanide ions (Gd(3+), Yb(3+) and Er(3+)/Tm(3+)) endows the Lu-UCNPs with high T(1)-enhancement, bright upconversion luminescence (UCL) emissions, and excellent X-ray absorption coefficient. Moreover, the as-prepared Lu-UCNPs are stable in water for more than six months, due to the protection of sodium glutamate and diethylene triamine pentacetate acid (DTPA) coordinating ligands on the surface. Lu-UCNPs have been successfully applied to the trimodal CT/MR/UCL lymphatic imaging on the modal of small animals. It is worth noting that Lu-UCNPs could be used for imaging even after preserving for over six months. In vitro transmission electron microscope (TEM), methyl thiazolyl tetrazolium (MTT) assay and histological analysis demonstrated that Lu-UCNPs exhibited low toxicity on living systems. Therefore, Lu-UCNPs could be multimodal agents for CT/MR/UCL imaging, and the concept can be served as a platform technology for the next-generation of probes for multimodal imaging. Copyright © 2012 Elsevier Ltd. All rights reserved.

  19. A new scheduling algorithm for parallel sparse LU factorization with static pivoting

    Energy Technology Data Exchange (ETDEWEB)

    Grigori, Laura; Li, Xiaoye S.

    2002-08-20

    In this paper we present a static scheduling algorithm for parallel sparse LU factorization with static pivoting. The algorithm is divided into mapping and scheduling phases, using the symmetric pruned graphs of L' and U to represent dependencies. The scheduling algorithm is designed for driving the parallel execution of the factorization on a distributed-memory architecture. Experimental results and comparisons with SuperLU{_}DIST are reported after applying this algorithm on real world application matrices on an IBM SP RS/6000 distributed memory machine.

  20. The regulation of prostitution in Beyoğlu (1875-1915).

    Science.gov (United States)

    özbek, Müge

    2010-01-01

    This study examines the development and nature of the regulation of prostitution in Beyoğlu during the late Ottoman Empire with special emphasis on the way the regulationist regime reinforced existing patterns of class and gender domination. The regulation of prostitution became a matter of urgency in the last decades of the nineteenth century in Istanbul, particularly in Beyoğlu, the cosmopolitan centre of the city. Through this process, the protests of the local residents of the area objecting to the proliferation of prostitution in their neighbourhoods played a crucial role in prompting the governmental authorities to tighten the regulations.

  1. Production of non carrier added (n.c.a.) {sup 177}Lu for radiopharmaceutical applications

    Energy Technology Data Exchange (ETDEWEB)

    Barkhausen, Christoph

    2011-09-06

    The goal of this dissertation was the development of a process to produce non carrier added {sup 177}Lu at the FRM II. For this purpose, preparative chromatographic methods were evaluated and applied. The highest quality of the nuclide which could only be achieved through a complex chemical process, has been already been proven by clinical studies to be very advantageous. The process has been built up in a hot cell as a semi-automated process and is now being adapted to the requirements of the 'Arzneimittelgesetz' in order to establish n.c.a. {sup 177}Lu as a pharmaceutical product.

  2. Isomeric ratio measurements for the radiative neutron capture 176Lu(n,γ at DANCE

    Directory of Open Access Journals (Sweden)

    Denis-Petit D.

    2017-01-01

    Full Text Available The isomeric ratios for the neutron capture reaction 176Lu(n,γ to the Jπ = 5/2−, 761.7 keV, T1/2 = 32.8 ns and the Jπ = 15/2+, 1356.9 keV, T1/2 = 11.1 ns levels of 177Lu, have been measured for the first time with the Detector for Advanced Neutron Capture Experiments (DANCE at the Los Alamos National Laboratory. These measured isomeric ratios are compared with TALYS calculations.

  3. L'U. Una història de família

    OpenAIRE

    Montserrat i Torrents, Josep

    1994-01-01

    El fals problema de l'U. Les nocions connexes d'ordre i d'unitat es troben presents ja en el pensament quodidià. Un moble tan familiar com un armari ofereix un feix de suggerències metafísiques sobre les coses, el lloc de les coses i els noms dels llocs de les coses. Agustí pensava probablement en l'armari de la seva mare quan proposà la seva bella definició d'ordre: ordo est parium disparium que rerum suo cuique loco tribuens dispositio. Filosòficament, l'U comparegué amb agressivitat ...

  4. Development of the therapeutic radiopharmaceutical 117Lu-DOTA-Minigastrin for potential use in PRRT

    International Nuclear Information System (INIS)

    Lopez Bularte, Ana C.; Nevares, Noemi; Zapata, Miguel; Perez, Juan; Crudo, Jose L.

    2009-01-01

    Objective: The main objectives of this work were to obtain 177 Lu-DOTA-Minigastrin with high radiochemical purity (RP) and specific activity (SA) as high as possible, using locally produced medium SA 177 LuCl3 (range 6,36-9,73 Ci/mg of 176 Lu), and to carry out in vitro and in vivo stability tests. Materials and methods: For a typical labelling, 20 or 15 μg of DOTA-MG (pi Chem, Austria) dissolved in ammonium acetate buffer pH 6 were mixed with 1mCi of 177 LuCl3 (SA = 6,36, 7,52 y 9,73 Ci/mg). The solution was incubated for 30 min. at 80 C degrees (pH 5,5). The stability assays in saline (SS) were carried out by incubation of the radiopharmaceutical with SA of 0.05 mCi/ μg of peptide in 80 μ of SS for 24 and 48 h at room temperature. The stability assays in human serum (HS) were carried out by incubation of 2.5 μ of 177 Lu-DOTA-MG with SA of 0.05 mCi/ μg of peptide in 500 μl of HS for 15 min. and 2 h at 37 C degrees. The samples were centrifuged at 3000 xg for 5 min. The supernatant (SN) was taken and acetonitrile (ACN) was added in a ratio 2:3 (SP:ACN). The solution was centrifuged at 3000 xg for 5 min. and the resulting supernatant was concentrated by ultra-filtration (Vivaspin 500, Sartorius). The concentrated SN was analyzed by Reverse Phase High Performance Liquid Chromatography (RP-HPLC) in order to determine the radiochemical purity. The serum protein binding was calculated taking into account the relation between the pellets activity in respect to the total activity. Bio distributions of 177 Lu-DOTA-MG in normal mice were done at 15 and 30 min., 1 and 4 h p.i. The results were expressed as percentage of injected activity per gram of tissue (%IAgr). Results: 20 μg of peptide were labelled with different SA 177 LuCl3 (6,36, 7,52 and 9,73 Ci/mg of 176 Lu) resulting in high radiochemical purities 96,31 %, 98,95 % and 97.57 %, respectively (SA 0.05 mCi/μg of peptide). 15 ug of peptide were labelled with 177 LuCl3 (SA 7,52 Ci/mg of 176 Lu) obtaining a

  5. Optimization of LSO/LuYAP phoswich detector for small animal PET

    International Nuclear Information System (INIS)

    Jung, Jin Ho; Choi, Yong; Chung, Yong Hyun; Devroede, Olivier; Krieguer, Magalie; Bruyndonckx, Peter; Tavernier, Stefaan

    2007-01-01

    LSO/LuYAP phoswich detectors for small animal PET were developed to measure the depth of interaction (DOI), and to improve the spatial resolution at the edge of the field of view (FOV). The aim of this study was to optimize the optical coupling conditions between the crystal and photomultiplier tube (PMT) to maximize the light-collection efficiency, and to develop a method for rejecting scatter events by applying an equal energy window in each crystal layer. The light yields of the phoswich detector were estimated by changing the refractive index of the optical coupling material using a DETECT simulation. The accuracy of the DOI measurement on the phoswich detector, using an optical coupling material with the optimal light yield, were evaluated experimentally and compared with the air condition. The energy window for the photopeak events cannot be applied properly because the light outputs of LSO and LuYAP are different. The LSO/LuYAP photopeaks need to be superposed in order to effectively discriminate the scattered events by applying an equal energy window. The photopeaks of the LSO and LuYAP can be superposed by inserting a reflecting material between the crystals. The optimal coverage ratio of the inserting material was derived from a DETECT simulation, and its performance was investigated. In the simulation result, optimal refractive index of the optical coupling material was 1.7. The average DOI measurement errors of the LSO/LuYAP were 0.6%/3.4% and 4.9%/41.4% in the phoswich detector with and without an optical coupling material, respectively. The photopeaks of the LSO and LuYAP were superposed by covering 75% of the contact surface between the crystals with white Teflon. The DOI measurement errors of the LSO/LuYAP were 0.2%/2.4%. In this study, the optimal condition of the optical coupling material inserted between the crystal and PMT was derived to improve the accuracy of DOI measurement, and a photopeak superposition method of the LSO and LuYAP was

  6. Improving quantitative dosimetry in (177)Lu-DOTATATE SPECT by energy window-based scatter corrections

    DEFF Research Database (Denmark)

    de Nijs, Robin; Lagerburg, Vera; Klausen, Thomas L

    2014-01-01

    and the activity, which depends on the collimator type, the utilized energy windows and the applied scatter correction techniques. In this study, energy window subtraction-based scatter correction methods are compared experimentally and quantitatively. MATERIALS AND METHODS: (177)Lu SPECT images of a phantom...... technique, the measured ratio was close to the real ratio, and the differences between spheres were small. CONCLUSION: For quantitative (177)Lu imaging MEGP collimators are advised. Both energy peaks can be utilized when the ESSE correction technique is applied. The difference between the calculated...

  7. Double ferromagnetism in single-crystal Gd-Y-Lu alloys

    International Nuclear Information System (INIS)

    Ito, T.; Oka, M.; Legvold, S.; Beaudry, B.J.

    1984-01-01

    Magnetization, electrical resistivity, specific-heat and thermal-expansion measurements have been made on Gd-Y-Lu single crystals. Low isofield magnetization data for the a-axis sample of Gd 75 Y/sub 17.5/ Lu/sub 7.5/ exhibit two different Curie-Weiss regimes, which suggests double ferromagnetism. Electrical resistivity, specific-heat, and thermal-expansion data show two anomalies at the transition temperatures. The anomaly at 231.5 K shows a lambda-type second-order phase transition and the anomaly at 223 K shows a sharp spike first-order phase transition

  8. Tl response of KMgF{sub 3}: Lu + PTFE at ultraviolet radiation; Respuesta Tl de KMgF{sub 3}: Lu + PTFE a radiacion ultravioleta

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, P R [Instituto Nacional de Investigaciones Nucleares, A.P. 18 -1027, 11801 Mexico D.F. (Mexico); Alarcon, N G [Facultad de Quimica, Universidad Autonoma del Estado de Mexico. Paseo Tollocan, Esq. con Jesus Carranza, 50180 Toluca, Estado de Mexico (Mexico); Furetta, C; Azorin, J [Universidad Autonoma Metropolitana- Iztapalapa, San Rafael Atlixco 186, 09340 Mexico. D.F. (Mexico)

    2003-07-01

    Ionizing radiation has different types of interaction with a crystalline solid. However, only few effects are interesting to optimize some thermoluminescent (Tl) properties of certain Tl materials. This paper presents results obtained by irradiating KMgF{sub 3}: Lu + Ptfe Tl dosimeters with ultraviolet (UV) radiation previously exposed to gamma radiation. These results showed that those dosimeters not exposed previously to gamma radiation did not presented any Tl signal. Meanwhile, those previously submitted to gamma irradiation showed that their sensitivity was increased as the gamma dose increased. The glow curve of sensitized KMgF{sub 3}: Lu + Ptfe exposed to UV radiation, presented the dosimetric pea at 212 C. This makes this material to be promissory for measuring UV radiation. (Author)

  9. Tumoral fibrosis effect on the radiation absorbed dose of 177Lu-Tyr3-octreotate-gold nanoparticles and 177Lu-Tyr3-octreotate radiopharmaceuticals

    International Nuclear Information System (INIS)

    Zambrano R, O. D.

    2015-01-01

    In this work was comparatively evaluated the effect of tumoral fibrosis in the radiation absorbed dose of the radiopharmaceutical 177 Lu-Tyr 3 -octreotate with and without gold nanoparticles. For this, was used an experimental array of tumoral fibrosis and computer models based on Monte Carlo calculations to simulate tumoral micro environments without fibrosis and with fibrosis. The computer simulation code Penelope (Penetration Energy Loss of Positron and Electrons) and MCNP (Monte Carlo N-particle Transport Code System) which are based on the Monte Carlo methodology were used to create the computer models for the simulation of the transport of particles (emitted by 177 Lu) in the micro environments (without fibrosis and with fibrosis) with the purpose of calculating the radiation absorbed dose in the interstitial space and in the nucleus of cancer cells. The first computational model consisted of multiple concentric spheres (as onion shells) with the radioactive source homogeneously distributed in the shell between 5 and 10 μm in diameter which represents the internalization of the radioactive source into the cell cytoplasm as it occurs in target specific radiotherapy. The concentric spheres were useful to calculate the radiation absorbed dose in depth in the models without fibrosis and with fibrosis. Furthermore, there were constructed other computer models using two different codes that simulate the transport of radiation (Penelope and MCNP). These models consist of seven spheres that represent cancer cells (HeLa cells) of 10 μm in diameter and each one of them contain another smaller sphere in the center that represents the cell nucleus. A comparison was done of the radiation absorbed dose in the nucleus of the cells, calculated with both codes, Penelope and MCNP. The radioactive source ( 177 Lu) used for the simulations was given to the codes by means of a convoluted spectrum of the most important beta particles (high percentage emission). To this spectrum

  10. Investigation into Plastic Cards

    Directory of Open Access Journals (Sweden)

    Neringa Stašelytė

    2015-03-01

    Full Text Available The article examines the strength of laminating plastic cards at different lamination temperatures. For investigation purposes, two types of plastic substrate and films have been used. Laminate strength has been tested (CMYK to establish the impact of colours on the strength of laminate. The paper compares inks supplied by two different producers. The colour characteristics of CIE L*a*b* space before and after the lamination process have been found. According to lamination strength and characteristics of the colours, the most suitable inks, temperature and films have been chosen.

  11. Joining by plastic deformation

    DEFF Research Database (Denmark)

    Mori, Ken-ichiro; Bay, Niels; Fratini, Livan

    2013-01-01

    As the scale and complexity of products such as aircraft and cars increase, demand for new functional processes to join mechanical parts grows. The use of plastic deformation for joining parts potentially offers improved accuracy, reliability and environmental safety as well as creating opportuni......As the scale and complexity of products such as aircraft and cars increase, demand for new functional processes to join mechanical parts grows. The use of plastic deformation for joining parts potentially offers improved accuracy, reliability and environmental safety as well as creating...

  12. Elastic plastic fracture mechanics

    International Nuclear Information System (INIS)

    Simpson, L.A.

    1978-07-01

    The application of linear elastic fracture mechanics (LEFM) to crack stability in brittle structures is now well understood and widely applied. However, in many structural materials, crack propagation is accompanied by considerable crack-tip plasticity which invalidates the use of LEFM. Thus, present day research in fracture mechanics is aimed at developing parameters for predicting crack propagation under elastic-plastic conditions. These include critical crack-opening-displacement methods, the J integral and R-curve techniques. This report provides an introduction to these concepts and gives some examples of their applications. (author)

  13. Overall survival and response pattern of castration-resistant metastatic prostate cancer to multiple cycles of radioligand therapy using [{sup 177}Lu]Lu-PSMA-617

    Energy Technology Data Exchange (ETDEWEB)

    Ahmadzadehfar, Hojjat; Wegen, Simone; Yordanova, Anna; Kuerpig, Stefan; Eppard, Elisabeth; Wei, Xiao; Schlenkhoff, Carl; Essler, Markus [University Hospital Bonn, Department of Nuclear Medicine, Bonn (Germany); Fimmers, Rolf [University of Bonn, Institute for Medical Biometry, Informatics and Epidemiology, Bonn (Germany); Hauser, Stefan [University Hospital Bonn, Department of Urology, Bonn (Germany)

    2017-08-15

    Up to 30% of patients with castration-resistant prostate cancer (CRPC) do not show any response to the first cycle of radioligand therapy (RLT) with [{sup 177}Lu]Lu-PSMA-617 (Lu-PSMA). We evaluated patient response to the second and third cycles of RLT in patients that underwent at least three cycles. The second aim of this study was to calculate the median overall survival (OS) of responders and non-responders after the first cycle and after all three cycles of RLT. CRPC patients were treated with Lu-PSMA, with a median interval of 8 weeks between each cycle. The tumour marker prostate-specific antigen (PSA) was used as the marker for response evaluation. Fifty-two patients underwent a total of 190 cycles of RLT (3-6 cycles per patient). Of these, 80.8% showed a decline in PSA 2 months after the first cycle, with 44.2% showing a PSA decline of ≥50%. When compared to baseline PSA, 73.1% showed a PSA decline after the third cycle. 50% of patients that did not show any response to the first cycle also did not respond to the second and third cycles. The median OS was 60 weeks in all patients. The median OS was significantly longer for patients that showed any PSA decline after the first cycle compared to patients without PSA decline (68 vs. 33 weeks). There was a significant difference in median OS between responders and non-responders for a change in PSA after the third cycle compared to baseline PSA. Patients with a positive response to RLT, regardless of the rate of decline, had a significantly longer median OS. Of the patients that did not show any response to the first cycle, 50% responded to the second or third cycles. (orig.)

  14. Overall survival and response pattern of castration-resistant metastatic prostate cancer to multiple cycles of radioligand therapy using [177Lu]Lu-PSMA-617.

    Science.gov (United States)

    Ahmadzadehfar, Hojjat; Wegen, Simone; Yordanova, Anna; Fimmers, Rolf; Kürpig, Stefan; Eppard, Elisabeth; Wei, Xiao; Schlenkhoff, Carl; Hauser, Stefan; Essler, Markus

    2017-08-01

    Up to 30% of patients with castration-resistant prostate cancer (CRPC) do not show any response to the first cycle of radioligand therapy (RLT) with [ 177 Lu]Lu-PSMA-617 (Lu-PSMA). We evaluated patient response to the second and third cycles of RLT in patients that underwent at least three cycles. The second aim of this study was to calculate the median overall survival (OS) of responders and non-responders after the first cycle and after all three cycles of RLT. CRPC patients were treated with Lu-PSMA, with a median interval of 8 weeks between each cycle. The tumour marker prostate-specific antigen (PSA) was used as the marker for response evaluation. Fifty-two patients underwent a total of 190 cycles of RLT (3-6 cycles per patient). Of these, 80.8% showed a decline in PSA 2 months after the first cycle, with 44.2% showing a PSA decline of ≥50%. When compared to baseline PSA, 73.1% showed a PSA decline after the third cycle. 50% of patients that did not show any response to the first cycle also did not respond to the second and third cycles. The median OS was 60 weeks in all patients. The median OS was significantly longer for patients that showed any PSA decline after the first cycle compared to patients without PSA decline (68 vs. 33 weeks). There was a significant difference in median OS between responders and non-responders for a change in PSA after the third cycle compared to baseline PSA. Patients with a positive response to RLT, regardless of the rate of decline, had a significantly longer median OS. Of the patients that did not show any response to the first cycle, 50% responded to the second or third cycles.

  15. Luminescent properties of LuAG:Yb and YAG:Yb single crystalline films grown by Liquid Phase Epitaxy method

    International Nuclear Information System (INIS)

    Zorenko, Yu; Zorenko, T.; Gorbenko, V.; Voznyak, T.; Popielarski, P.; Batentschuk, M.; Osvet, A.; Brabec, Ch; Kolobanov, V.; Spasky, D.; Fedorov, A.

    2016-01-01

    In this work, investigation of the spectroscopic parameters of the luminescence of Yb"3"+ ions in single crystalline films of Lu_3Al_5O_1_2 and Y_3Al_5O_1_2 garnets was performed using the synchrotron radiation excitation with the energy in the range of Yb"3"+ charge transitions (CT), exciton range and the onset of interband transitions of these garnets. The basic spectroscopic parameters of the Yb"3"+ CT luminescence in LuAG and YAG hosts were determined and summarized with taking into account the differences in the band gap structure of these garnets. - Highlights: • Single crystalline films of Yb doped LuAG and YAG garnets were grown by LPE method. • Yb"3"+ luminescence of LuAG:Yb and YAG:Yb film were studied using synchrotron radiation. • Basic parameters of Yb"3"+ charge transfer luminescence in LuAG and YAG were determined.

  16. Lu-Hf isotope systematics of fossil biogenic apatite and their effects on geochronology

    Science.gov (United States)

    Herwartz, Daniel; Münker, Carsten; Tütken, Thomas; Hoffmann, J. Elis; Wittke, Andreas; Barbier, Bruno

    2013-01-01

    Reliable methods for direct dating of biogenic apatite from pre-Pleistocene fossils are currently not available, and recent attempts using the Lu-Hf decay system yielded highly inaccurate ages for both bones and teeth. The geological processes accounting for this poor accuracy of Lu-Hf chronometry are not yet understood. Here we explore Lu-Hf systematics in fossil bones and teeth in detail, by applying five different sample digestion techniques that are tested on bones and composites of bone and sediment. Our current dataset implies that dissolution methods only slightly affect the resulting Lu-Hf ages, while clear differences between the individual digestion techniques became apparent for element concentrations. By analysing the insoluble leftovers from incomplete sample dissolution, four main reservoirs of Hf in fossil bones were identified: (1) a radiogenic end-member associated with apatite; (2) an unradiogenic end-member represented by the authigenic minerals or the embedding sediment; (3) a highly unradiogenic end-member that can be attributed to detrital zircon; and (4) a moderately soluble phase (probably a Zr(Hf)-phosphate) that yielded very low Lu/Hf but a highly radiogenic Hf isotope composition at the same time. This Zr(Hf)-phase must have been precipitated within the fossil bone sample at a late stage of burial history, thereby incorporating radiogenic 176Hf released from apatite surfaces over geological timescales. A second focus of our study is the effect of different sediment matrices and of crystal size on the preservation of pristine Lu-Hf isotope compositions in bioapatite. Because near-depositional Lu-Hf ages of phosphate fossils have previously been reported for the London Clay (England) and a calcareous marl from Tendaguru (Tanzania), we herein investigate specimens fossilised in carbonate matrices (calcareous marl from Oker, Germany; carbonate concretions from the Santana Formation, Brazil; carbonate from the Eifel, Germany) and argillaceous

  17. An electro-amalgamation approach to isolate no-carrier-added 177Lu from neutron irradiated Yb for biomedical applications

    International Nuclear Information System (INIS)

    Chakravarty, Rubel; Das, Tapas; Dash, Ashutosh; Venkatesh, Meera

    2010-01-01

    Introduction: A novel two-step separation process for the production of no-carrier-added (NCA) 177 Lu from neutron irradiated Yb target through an electrochemical pathway employing mercury-pool cathode has been developed. Methods: A two-cycle electrolysis procedure was adopted for separation of 177 Lu from 177 Lu/Yb mixture in lithium citrate medium. The influence of different experimental parameters on the separation process was investigated and optimized for the quantitative deposition of Yb in presence of 177 Lu. The first electrolysis was performed for 50 min in the 177 Lu/Yb feed solution at pH 6 applying a potential of 8 V using platinum electrode as anode and mercury as the cathode. The second electrolysis was performed under the same conditions using fresh electrodes. The radionuclidic and chemical purity of 177 Lu was determined by using gamma ray spectrometry and atomic absorption spectrometry. The suitability of 177 Lu for biomedical applications was ascertained by labeling 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid D-Phe 1 -Tyr 3 -octreotate(DOTA-TATE) with 177 Lu. Results: This process could provide NCA 177 Lu with >99.99% radionuclidic purity and an overall separation yield of ∼99% was achieved within 3-4 h. The Hg content in the product was determined to be 98% was obtained with DOTA-TATE under the optimized reaction conditions. Conclusions: An efficient strategy for the separation of NCA 177 Lu, suitable for biomedical applications, has been developed.

  18. An electro-amalgamation approach to isolate no-carrier-added 177Lu from neutron irradiated Yb for biomedical applications.

    Science.gov (United States)

    Chakravarty, Rubel; Das, Tapas; Dash, Ashutosh; Venkatesh, Meera

    2010-10-01

    A novel two-step separation process for the production of no-carrier-added (NCA) (177)Lu from neutron irradiated Yb target through an electrochemical pathway employing mercury-pool cathode has been developed. A two-cycle electrolysis procedure was adopted for separation of (177)Lu from (177)Lu/Yb mixture in lithium citrate medium. The influence of different experimental parameters on the separation process was investigated and optimized for the quantitative deposition of Yb in presence of (177)Lu. The first electrolysis was performed for 50 min in the (177)Lu/Yb feed solution at pH 6 applying a potential of 8 V using platinum electrode as anode and mercury as the cathode. The second electrolysis was performed under the same conditions using fresh electrodes. The radionuclidic and chemical purity of (177)Lu was determined by using gamma ray spectrometry and atomic absorption spectrometry. The suitability of (177)Lu for biomedical applications was ascertained by labeling 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid D-Phe(1)-Tyr(3)-octreotate(DOTA-TATE) with (177)Lu. This process could provide NCA (177)Lu with >99.99% radionuclidic purity and an overall separation yield of ∼99% was achieved within 3-4 h. The Hg content in the product was determined to be 98% was obtained with DOTA-TATE under the optimized reaction conditions. An efficient strategy for the separation of NCA (177)Lu, suitable for biomedical applications, has been developed. Copyright © 2010 Elsevier Inc. All rights reserved.

  19. Facile controlled synthesis different morphologies of LuBO3:Ln3+ (Ln = Eu, Tb) phosphors and tunable luminescent properties

    International Nuclear Information System (INIS)

    Leng, Zhihua; Xiong, Hailong; Li, Linlin; Zhang, Nannan; Liu, Yali; Gan, Shucai

    2015-01-01

    Sphere-like and cauliflower-like hexagonal-vaterite LuBO 3 have been successfully synthesized for the first time via a chemical conversion route using Lu(OH)CO 3 colloid spheres as sacrificial precursor and H 3 BO 3 as boron source without any additional surfactant. FTIR analysis provides an additional evidence of the formation of vaterite-type LuBO 3 in this method. It was found that, an appropriate amount ethanol in the hydrothermal process has a great effect on the products' morphology and crystallinity. Time-dependent experiments indicate that the formation of LuBO 3 crystals went through a two-stage growth process, which involves a fast nucleation of primary particles followed by a slow aggregation and crystallization of primary particles. An investigation on the photoluminescence (PL) properties of LuBO 3 :Eu 3+ phosphors with different morphologies indicates that their PL intensity are dependent on their crystallinity. The effect of Eu 3+ and Tb 3+ doping concentration on PL intensity were also investigated and the quenching concentration of LuBO 3 :Eu 3+ and LuBO 3 :Tb 3+ is 0.25 and 0.20, respectively. Moreover, for Eu 3+ /Tb 3+ doped LuBO 3 phosphors, the color tones can be tuned from green, through green–yellow and yellow, and then to red by simply adjusting the relative doping concentrations of the Tb 3+ and Eu 3+ ions. - Highlights: • Sphere-like and cauliflower-like LuBO 3 were obtained by a conversion route. • This method used Lu(OH)CO 3 and H 3 BO 3 as the precursors for the first time. • Ethanol can control the products' morphology, crystallinity and PL intensity. • The emitting color tones vary with Tb 3+ /Eu 3+ doped concentration

  20. Plastic flashtube chambers

    International Nuclear Information System (INIS)

    Frisken, W.R.

    1977-01-01

    A brief discussion is given of the use and operation of plastic flashtube chambers. Gas leaks, electric pulsing, the glow discharge, and readout methods are considered. Three distinct problems with high rate applications deal with resolving time, dead time, and polarization/neutralization of the chamber

  1. Plastic Surgery: Tackling Misconceptions

    African Journals Online (AJOL)

    will succeed. First impressions tend to last, and if young people's first impression of plastic surgeons is that they spend much of their time doing cosmetic surgery then this is a first impression that might be long ... Res 2014;4 Suppl S3:169‑70. Access this article online. Quick Response Code: Website: www.amhsr.org. DOI:.

  2. Biobased Plastics 2012

    NARCIS (Netherlands)

    Bolck, C.H.; Ravenstijn, J.; Molenveld, K.; Harmsen, P.F.H.

    2011-01-01

    Dit boek geeft inzicht in de huidige op de markt verkrijgbare biobased plastics en de te verwachten ontwikkelingen. Er wordt gekeken naar zowel thermoplastische als thermohardende materialen. Het boek biedt inzicht in de productie, verwerking en eigenschappen van de verschillende types. Daarnaast

  3. New plastic recycling technology

    Science.gov (United States)

    Greater than 60% of the total plastic content of municipal solid waste is comprised of polyolefins (high-density, low-density, and linear polyethylene and polypropylene. Polyethylene (PE) is the largest-volume component but presents a challenge due to the absence of low-energy de...

  4. Reliability of Plastic Slabs

    DEFF Research Database (Denmark)

    Thoft-Christensen, Palle

    1989-01-01

    In the paper it is shown how upper and lower bounds for the reliability of plastic slabs can be determined. For the fundamental case it is shown that optimal bounds of a deterministic and a stochastic analysis are obtained on the basis of the same failure mechanisms and the same stress fields....

  5. Individual differences in behavioural plasticities.

    Science.gov (United States)

    Stamps, Judy A

    2016-05-01

    Interest in individual differences in animal behavioural plasticities has surged in recent years, but research in this area has been hampered by semantic confusion as different investigators use the same terms (e.g. plasticity, flexibility, responsiveness) to refer to different phenomena. The first goal of this review is to suggest a framework for categorizing the many different types of behavioural plasticities, describe examples of each, and indicate why using reversibility as a criterion for categorizing behavioural plasticities is problematic. This framework is then used to address a number of timely questions about individual differences in behavioural plasticities. One set of questions concerns the experimental designs that can be used to study individual differences in various types of behavioural plasticities. Although within-individual designs are the default option for empirical studies of many types of behavioural plasticities, in some situations (e.g. when experience at an early age affects the behaviour expressed at subsequent ages), 'replicate individual' designs can provide useful insights into individual differences in behavioural plasticities. To date, researchers using within-individual and replicate individual designs have documented individual differences in all of the major categories of behavioural plasticities described herein. Another important question is whether and how different types of behavioural plasticities are related to one another. Currently there is empirical evidence that many behavioural plasticities [e.g. contextual plasticity, learning rates, IIV (intra-individual variability), endogenous plasticities, ontogenetic plasticities) can themselves vary as a function of experiences earlier in life, that is, many types of behavioural plasticity are themselves developmentally plastic. These findings support the assumption that differences among individuals in prior experiences may contribute to individual differences in behavioural

  6. Plasticity characteristic obtained by indentation

    International Nuclear Information System (INIS)

    Mil'man, Yu.V.; Chugunova, S.I.; Goncharova, I.V.

    2011-01-01

    Methods for determination plasticity characteristic δH in the measurement of hardness and nanohardness are considered. Parameter δH characterizes the plasticity of a material by the part of plastic deformation in the total elastic-plastic deformation. The value of δH is defined for metals with different types of crystal lattice, covalent and partially covalent crystals, intermetallics, metallic glasses and quasicrystals. It is discussed the dependence of the plasticity characteristic δH on structural factors and temperature. Parameter δH allows to analyze and compare the plasticity of materials which are brittle at standard mechanical tests. The combination of hardness H, as the strength characteristic, and the plasticity characteristic δH makes possible the better characterization of mechanical behavior of materials than only the hardness H. The examples of plasticity characteristic δH application are represented.

  7. Reducing renal uptake of 9Y- and 177Lu-labeled alpha-melanocyte stimulating hormone peptide analogues

    International Nuclear Information System (INIS)

    Miao Yubin; Fisher, Darrell R.; Quinn, Thomas P.

    2006-01-01

    Objective: The purpose of this study was to improve the tumor-to-kidney uptake ratios of 9 Y- and 177 Lu-[1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-Re-Cys 3,4,1 , D-Phe 7 , Arg 11 ]α-melanocyte stimulating hormone 3-13 {DOTA-Re(Arg 11 )CCMSH} through coupling a negatively charged glutamic acid (Glu) to the peptide sequence. Methods: A new peptide of DOTA-Re(Glu 2 , Arg 11 )CCMSH was designed, synthesized and labeled with 9 Y and 177 Lu. Pharmacokinetics of 9 Y- and 177 Lu-DOTA-Re(Glu 2 , Arg 11 )CCMSH was determined in B16/F1 murine melanoma-bearing C57 mice. Results: 9 Y- and 177 Lu-DOTA-Re(Glu 2 , Arg 11 )CCMSH exhibited significantly (P 9 Y- and 177 Lu-DOTA-Re(Arg 11 )CCMSH at 30 min and at 2, 4 and 24 h after dose administration. The renal uptake values of 9 Y- and 177 Lu-DOTA-Re(Glu 2 , Arg 11 )CCMSH were 28.16% and 28.81% of those of 9 Y- and 177 Lu-DOTA-Re(Arg 11 )CCMSH, respectively, at 4 h postinjection. 9 Y- and 177 Lu-DOTA-Re(Glu 2 , Arg 11 )CCMSH displayed higher tumor-to-kidney uptake ratios than 9 Y- and 177 Lu-DOTA-Re(Arg 11 )CCMSH at 30 min and at 2, 4 and 24 h after dose administration. The tumor-to-kidney uptake ratio of 9 Y- and 177 Lu-DOTA-Re(Glu 2 , Arg 11 )CCMSH was 2.28 and 1.69 times of 9 Y- and 177 Lu-DOTA-Re(Arg 11 )CCMSH, respectively, at 4 h postinjection. The 9 Y- and 177 Lu-DOTA-Re(Glu 2 , Arg 11 )CCMSH activity accumulation was low in normal organs except for kidney. Conclusions: Coupling a negatively charged amino acid (Glu) to the CCMSH peptide sequence dramatically reduced the renal uptake values and increased the tumor-to-kidney uptake ratios of 9 Y- and 177 Lu-DOTA-Re(Glu 2 , Arg 11 )CCMSH, facilitating their potential applications as radiopharmaceuticals for targeted radionuclide therapy of melanoma

  8. Friction induced hunting limit cycles : a comparison between the LuGre and switch friction model

    NARCIS (Netherlands)

    Hensen, R.H.A.; Molengraft, van de M.J.G.; Steinbuch, M.

    2003-01-01

    In this paper, friction induced limit cycles are predicted for a simple motion system consisting of a motor-driven inertia subjected to friction and a PID-controlled regulator task. The two friction models used, i.e., (i) the dynamic LuGre friction model and (ii) the static switch friction model,

  9. Weak antilocalization effect and noncentrosymmetric superconductivity in a topologically nontrivial semimetal LuPdBi

    KAUST Repository

    Xu, Guizhou; Wang, Wenhong; Zhang, Xiaoming; Du, Yin; Liu, Enke; Wang, Shouguo; Wu, Guangheng; Liu, Zhongyuan; Zhang, Xixiang

    2014-01-01

    A large number of half-Heusler compounds have been recently proposed as three-dimensional (3D) topological insulators (TIs) with tunable physical properties. However, no transport measurements associated with the topological surface states have been observed in these half-Heusler candidates due to the dominating contribution from bulk electrical conductance. Here we show that, by reducing the mobility of bulk carriers, a two-dimensional (2D) weak antilocalization (WAL) effect, one of the hallmarks of topological surface states, was experimentally revealed from the tilted magnetic field dependence of magnetoconductance in a topologically nontrivial semimetal LuPdBi. Besides the observation of a 2D WAL effect, a superconducting transition was revealed at T c ∼ 1.7â.K in the same bulk LuPdBi. Quantitative analysis within the framework of a generalized BCS theory leads to the conclusion that the noncentrosymmetric superconductivity of LuPdBi is fully gapped with a possibly unconventional pairing character. The co-existence of superconductivity and the transport signature of topological surface states in the same bulk alloy suggests that LuPdBi represents a very promising candidate as a topological superconductor.

  10. High performance matrix inversion based on LU factorization for multicore architectures

    KAUST Repository

    Dongarra, Jack; Faverge, Mathieu; Ltaief, Hatem; Luszczek, Piotr R.

    2011-01-01

    on the available processing units. The reported results from our LU-based matrix inversion implementation significantly outperform the state-of-the-art numerical libraries such as LAPACK (5x), MKL (5x) and ScaLAPACK (2.5x) on a contemporary AMD platform with four

  11. Preparation and preclinical evaluation of (177)Lu-nimotuzumab targeting epidermal growth factor receptor overexpressing tumors

    Czech Academy of Sciences Publication Activity Database

    Beckford, Denis R.; Eigner, Sebastian; Eigner-Henke, Kateřina; Lebeda, Ondřej; Melichar, František; Beran, Miloš

    2012-01-01

    Roč. 39, č. 1 (2012), s. 3-13 ISSN 0969-8051 R&D Projects: GA MŠk 2B06165 Institutional research plan: CEZ:AV0Z10480505 Keywords : Radioimmunotherapy * Nimotuzumab * (177)Lu * Monoclonal antibody Subject RIV: FR - Pharmacology ; Medidal Chemistry Impact factor: 2.517, year: 2012

  12. Hüsteeria, seks ja selektiivne mälu / Anneli Porri

    Index Scriptorium Estoniae

    Porri, Anneli, 1980-

    2006-01-01

    Marge Monko näitus "Uurimusi kodanlusest" (Charcot' klassifitseeritud krambiasendeid esitab tantsija Krõõt Juurak) Hobusepea galeriis 17.-22. V; Jane Suviste ja Piibe Piirma näitus "Editeeritud mälu" Tallinna Linnagaleriis kuni 28. V; Andres Lõo kureeritud noortenäitus "Sex" Vaal-galeriis 2.-20. V

  13. Lu2O3-based storage phosphors. An (in)harmonious family

    NARCIS (Netherlands)

    Kulesza, Dagmara; Bolek, Paulina; Bos, A.J.J.; Zych, E

    2016-01-01

    Ceramics of Lu2O3 activated with either Tb3+ or Pr3+ and co-doped with one of the transition metal ions – Ti, Hf or Nb – were investigated for their energy storage properties. Photoluminescence, thermoluminescence (TL) and optically stimulated luminescence spectra were recorded and discussed

  14. Scintillation properties of YAlO3 doped with Lu and Nd perovskite single crystals

    Science.gov (United States)

    Akatsuka, Masaki; Usui, Yuki; Nakauchi, Daisuke; Kato, Takumi; Kawano, Naoki; Okada, Go; Kawaguchi, Noriaki; Yanagida, Takayuki

    2018-05-01

    YAlO3 (YAP) single crystals doped with Lu and Nd were grown by the Floating Zone (FZ) method to evaluate their scintillation properties particularly emissions in the near-infrared (NIR) range. The Nd concentration was fixed to 0 or 1 mol% while the Lu concentration was varied from 0 to 30%. When X-ray was irradiated, the scintillation of Nd-doped samples was observed predominantly at 1064 nm due to 4F3/2 → 4I11/2 transition of Nd3+. In contrast, a weak emission around 700 nm appeared in the samples doped with only Lu, and the emission origin was attributed to defect centers. In the Nd3+-doped samples, the decay time was 94-157 μs due to the 4f-4f transitions of Nd3+ whereas the Lu-doped samples showed signal with the decay time of 1.45-1.54 ms. The emission origin of the latter signal was attributed to the perovskite lattice defect.

  15. lu pole ainult meil, vaid ka meie haigustel / Tiina Sarv

    Index Scriptorium Estoniae

    Sarv, Tiina, 1949-

    2007-01-01

    Pärnus toimunud Eesti arstide Astra Zeneca ABC-konverentsi märksõna oli mälu. Konverentsil esinesid professorid Endel Tulving, Alan Altraja ja Anto Raukas, dotsendid Tiina Ristimäe ja Ursel Soomets, kirjandusteadlane Rutt Hinrikus, zooloog Aleksei Turovski ning arstid Anu Ambos ja Riina Kütner

  16. Specific heat and magnetism of LuFe.sub.6./sub.Al.sub.6./sub..

    Czech Academy of Sciences Publication Activity Database

    Svoboda, P.; Andreev, Alexander V.; Šantavá, Eva; Šebek, Josef

    2008-01-01

    Roč. 113, č. 1 (2008), s. 307-310 ISSN 0587-4246. [CSMAG'07. Košice, 09.07.2007-12.07.2007] Institutional research plan: CEZ:AV0Z10100520 Keywords : specific heat * LuFe 6 Al 6 Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 0.321, year: 2008

  17. Direct measurement of the inelastic neutron acceleration by 177mLu

    Directory of Open Access Journals (Sweden)

    Menelle A.

    2010-03-01

    Full Text Available The inelastic neutron acceleration (INNA cross section on the long-lived isomer state of 177mLu has been measured from a new isomeric target using a direct method. The detection of high energy neutrons has been performed using a specially designed setup and a cold neutron beam at the ORPHEE reactor facility in Saclay.

  18. Vene uut kunsti ühendab mälu / Teet Veispak

    Index Scriptorium Estoniae

    Veispak, Teet, 1955-

    2007-01-01

    Näitusest "Mälu tagasitulek" Kumu Kunstimuuseumis, kuraator Viktor Misiano. Lähemalt David Ter-Oganjani (sünd. 1981) tööst "Vanad loosungid", Dmitri Prigovi (sünd. 1940) videost, Juri Leidermani installatsioonist "Isa jutustus", Jevgeni Fiksi tööst "Song of Russia"

  19. Scintillation properties of a La,Lu-admix gadolinium pyrosilicate crystal

    Czech Academy of Sciences Publication Activity Database

    Kurosawa, S.; Shishido, T.; Suzuki, A.; Sugawara, T.; Nomura, A.; Yubuta, K.; Shoji, Y.; Yokota, Y.; Pejchal, Jan; Ohashi, Y.; Kamada, K.; Yoshikawa, A.

    2015-01-01

    Roč. 784, Jun (2015), s. 115-118 ISSN 0168-9002 Institutional support: RVO:68378271 Keywords : scintillator * pyrosilicate crystal * Ce-doped (La, Lu, Gd) Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.200, year: 2015

  20. Crystal fields at light rare-earth ions in Y and Lu

    DEFF Research Database (Denmark)

    Touborg, P.; Nevald, Rolf; Johansson, Torben

    1978-01-01

    Crystal-field parameters have been deduced for the light rare-earth solutes Ce, Pr, and Nd in Y or Lu hosts from measurements of the paramagnetic susceptibilities. In the analysis all multiplets in the lowest LS term were included. For a given host, crystal-field parameters divided by Stevens fac...

  1. Photoionization and photofragmentation of multiply charged Lu3N@C80 ions

    International Nuclear Information System (INIS)

    Hellhund, J; Borovik, A Jr; Holste, K; Ricz, S; Schippers, S; Müller, A; Klumpp, S; Martins, M

    2015-01-01

    Relative cross sections for photoionization and photofragmentation of endohedral fullerene Lu 3 N@C 80 q+ (q=1,2,3) ions have been measured employing the new photon-ion spectrometer PIPE at PETRA III. Prominent structures related to the carbon K-shell ionization threshold were observed in the energy range 280 to 330 eV. (paper)

  2. Wobbling phonon excitations, coexisting with normal deformed structures in 163Lu

    International Nuclear Information System (INIS)

    Jensen, D.R.; Hagemann, G.B.; Hamamoto, I.; Oedegard, S.W.; Bergstroem, M.; Herskind, B.; Sletten, G.; Toermaenen, S.; Wilson, J.N.; Tjoem, P.O.; Spohr, K.; Huebel, H.; Goergen, A.; Schoenwasser, G.; Bracco, A.; Leoni, S.; Maj, A.; Petrache, C.M.; Bednarczyk, P.; Curien, D.

    2002-01-01

    Wobbling is a rotational mode unique to a triaxial body. The Lu-Hf isotopes with N∼94 at high spin provide a possible region of nuclei with pronounced triaxiality. We have investigated 163 Lu through the fusion-evaporation reaction 139 La( 29 Si,5n) 163 Lu with a beam energy of 152 MeV. Three excited bands decaying into the known, presumably triaxial, superdeformed (TSD) band built on the i 13/2 proton orbital are observed. The electromagnetic properties of the connecting transitions from the two strongest populated excited TSD bands have been investigated. New particle-rotor calculations in which one i 13/2 quasiproton is coupled to the core of triaxial shape produce a variety of bands, whose properties can clearly be interpreted either as 'wobbling' or 'cranking' motion of the core. Evidence for the assignment of the excited TSD bands as one, and possibly even two wobbling phonon modes built on the yrast TSD band in 163 Lu is given. These triaxial bands coexist with bands built on quasiparticle excitations in the normal deformed (ND) minimum for which new data are also presented

  3. Weak antilocalization effect and noncentrosymmetric superconductivity in a topologically nontrivial semimetal LuPdBi

    KAUST Repository

    Xu, Guizhou

    2014-07-21

    A large number of half-Heusler compounds have been recently proposed as three-dimensional (3D) topological insulators (TIs) with tunable physical properties. However, no transport measurements associated with the topological surface states have been observed in these half-Heusler candidates due to the dominating contribution from bulk electrical conductance. Here we show that, by reducing the mobility of bulk carriers, a two-dimensional (2D) weak antilocalization (WAL) effect, one of the hallmarks of topological surface states, was experimentally revealed from the tilted magnetic field dependence of magnetoconductance in a topologically nontrivial semimetal LuPdBi. Besides the observation of a 2D WAL effect, a superconducting transition was revealed at T c ∼ 1.7â.K in the same bulk LuPdBi. Quantitative analysis within the framework of a generalized BCS theory leads to the conclusion that the noncentrosymmetric superconductivity of LuPdBi is fully gapped with a possibly unconventional pairing character. The co-existence of superconductivity and the transport signature of topological surface states in the same bulk alloy suggests that LuPdBi represents a very promising candidate as a topological superconductor.

  4. Lanthanide 4f-level location in AVO4:Ln3+ (A = La, Gd, Lu) crystals

    NARCIS (Netherlands)

    Krumpel, A.H.; Van der Kolk, E.; Cavalli, E.; Boutinaud, P.; Bettinelli, M.; Dorenbos, P.

    2009-01-01

    The spectral properties of LaVO4, GdVO4 and LuVO4 crystals doped with Ce3+, Pr3+, Eu3+ or Tb3+ have been investigated in order to determine the position of the energy levels relative to the valence and conduction bands of the hosts along the trivalent and divalent lanthanide series. Pr3+ and Tb3+

  5. Charge Carrier Trapping Processes in RE2O2S (RE = La, Gd, Y, and Lu)

    NARCIS (Netherlands)

    Luo, H.; Bos, A.J.J.; Dorenbos, P.

    2017-01-01

    Two different charge carrier trapping processes have been investigated in RE2O2S:Ln3+ (RE = La, Gd, Y, and Lu; Ln = Ce, Pr, and Tb) and RE2O2S:M (M = Ti4+ and Eu3+). Cerium, praseodymium and terbium act as recombination centers and hole trapping centers while host intrinsic defects provide the

  6. Problem of unstable pivots in the incomplete LU-conjugate gradient method

    International Nuclear Information System (INIS)

    Kershaw, D.S.

    1978-01-01

    Incomplete LU and incomplete-Cholesky conjugate gradient methods are becoming widely used in both laser and magnetic fusion research. In my original presentation of these methods, the problem of what to do if a pivot [L/sub ii/U/sub ii/) becomes very small or zero was raised and only partially answered by the suggestion that it be arbitrarily set to some non-zero value. In what follows it will be shown precisely how small the pivot can become before it must be fixed and precisely what value it should be set to in order to minimize the error in LU. Numerical examples will be given to show that not only does this prescription improve incomplete LU-conjugate gradient methods , but exact LU decomposition carried out with this prescription for handling small pivots and followed by a few linear or conjugate gradient iterations can be much faster than the permutations of rows and columns usually employed to circumvent small pivot problems

  7. New system for production of reactor medical radionuclides tested with Lu-176

    Czech Academy of Sciences Publication Activity Database

    Seifert, Daniel; Kropáček, Martin; Tomeš, Marek; Kučera, Jan; Lebeda, Ondřej

    2015-01-01

    Roč. 42, S (2015), s. 857-857 ISSN 1619-7070. [28th Annual congress of the European-Association-of-Nuclear-Medicine (EANM). 10.10.2015-14.10.2015, Hamburg] R&D Projects: GA MŠk(CZ) LM2011019 Institutional support: RVO:61389005 Keywords : Lu-177 * radionuclides * reactor Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders

  8. Unustagem kõvaketas, kasutagem operatiivmälu! / Katrin Ruus

    Index Scriptorium Estoniae

    Ruus, Katrin

    2008-01-01

    Valik Mart Viljuse, Katrin Teesi, Piret Räni, Reimo Võsa-Tangsoo, Merle ja Erki Kannuse ning rühmituste Puhas Rõõm ja Infotankistid viimaste aastate töödest näituseprojektina "Operatiivmälu" Pärnu Kunstnike Maja galeriis ja Pärnu Linnagaleriis. 11 ill

  9. Effects of therapy with [177Lu-DOTA0,Tyr3]octreotate on endocrine function

    International Nuclear Information System (INIS)

    Teunissen, Jaap J.M.; Kwekkeboom, Dik J.; Krenning, Eric P.; Jong, Frank H. de; Feelders, Richard A.; Aken, Maarten O. van; Herder, Wouter W. de; Rijke, Yolanda B. de

    2009-01-01

    Peptide receptor radionuclide therapy (PRRT) with radiolabelled somatostatin analogues is a novel therapy for patients with somatostatin receptor-positive tumours. We determined the effects of PRRT with [ 177 Lu-DOTA 0 ,Tyr 3 ]octreotate ( 177 Lu-octreotate) on glucose homeostasis and the pituitary-gonadal, pituitary-thyroid and pituitary-adrenal axes. Hormone levels were measured and adrenal function assessed at baseline and up to 24 months of follow-up. In 35 men, mean serum inhibin B levels were decreased at 3 months post-therapy (205 ± 16 to 25 ± 4 ng/l, p 4 ) levels decreased (17.7 ± 0.4 to 15.6 ± 0.6 pmol/l, p 3 ) levels did not change. Reverse triiodothyronine (rT 3 ) levels decreased (0.38 ± 0.03 to 0.30 ± 0.01 nmol/l, p 550 nmol/l, n = 18). Five patients developed elevated HbA 1c levels (> 6.5%). In men 177 Lu-octreotate therapy induced transient inhibitory effects on spermatogenesis, but non-SHBG-bound T levels remained unaffected. In the long term, gonadotropin levels decreased significantly in postmenopausal women. Only a few patients developed hypothyroidism or elevated levels of HbA 1c . Therefore, PRRT with 177 Lu-octreotate can be regarded as a safe treatment modality with respect to short- and long-term endocrine function. (orig.)

  10. High efficiency laser action in mildly doped Yb:LuYAG ceramics

    Czech Academy of Sciences Publication Activity Database

    Pirri, A.; Toci, G.; Li, J.; Xie, T.; Pan, Y.; Babin, Vladimir; Beitlerová, Alena; Nikl, Martin; Vannini, M.

    2017-01-01

    Roč. 73, Nov (2017), s. 312-318 ISSN 0925-3467 Institutional support: RVO:68378271 Keywords : laser ceramic s * Yb laser * mixed garnets * LuYAG Subject RIV: BM - Solid Matter Physics ; Magnetism OBOR OECD: Condensed matter physics (including formerly solid state physics, supercond.) Impact factor: 2.238, year: 2016

  11. Optical, luminescence and scintillation characteristics of non-stoichiometric LuAG:Ce ceramics

    Czech Academy of Sciences Publication Activity Database

    Liu, S.; Feng, X.; Mareš, Jiří A.; Babin, Vladimir; Nikl, Martin; Beitlerová, Alena; Shi, Y.; Zeng, Y.; Pan, Y.; D'Ambrosio, C.; Huang, Y.

    2016-01-01

    Roč. 169, Jan (2016), s. 72-77 ISSN 0022-2313 R&D Projects: GA ČR GAP204/12/0805 Institutional support: RVO:68378271 Keywords : non-stoichimetric LuAG:Ce ceramic s * radioluminescence * scintillation response * anti-site defects Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.686, year: 2016

  12. Potential renal toxicity bio-markers indicating radiation injury after 177Lu-octreotate treatment

    International Nuclear Information System (INIS)

    Dalmo, J.; Forssell-Aronsson, E.; Westberg, E.; Toernqvist, M.; Svedborn, L.; Barregaerd, L.

    2015-01-01

    Full text of publication follows. The kidneys are one of the most exposed non-tumor tissues and regarded as one of the main dose-limiting organs in peptide receptor radionuclide therapy (PRRT). [ 177 Lu-DOTA0, Tyr3]-octreotate ( 177 Lu-octreotate) has shown promising results in the treatment of somatostatin receptor over-expressing neuroendocrine tumors, but optimization is still needed. The ability to give each patient as much 177 Lu-octreotate as possible without inducing nephrotoxicity is necessary for an efficient treatment. However, due to large inter-individual differences in uptake and retention in the kidneys, there is a need for efficient methods that can indicate renal injury early. A possible way is to identify bio-markers for high risk of radiation nephrotoxicity. The aim of this study was to investigate the potential of using urinary retinol binding protein (RBP), and blood valinhydantoin (VH) as bio-markers of nephrotoxicity on adult mice after 177 Lu-octreotate treatment. BALB/c nude mice (n=6/group) were i.v. injected with 60 MBq or 120 MBq of 177 Lu-octreotate. The control group was mock treated with saline. Spot urine samples were collected before injection, and 14, 30, 60 and 90 days after injection. Analysis of RBP4 and creatinine was performed using Mouse RBP4 ELISA kit and Creatinine kit from R/D Systems, respectively. Erythrocytes were separated from whole blood samples collected 90 days after injection, and analysed for VH by LC-MS/MS. The ratio between VH and a volumetric standard was calculated. The RBP/creatinine level increased with time in both groups given 177 Lu-octreotate, with earlier and higher response for the 120 MBq group. No clear change in VH level between the different groups was observed. The results show that RBP may be a promising new bio-marker for radiation induced kidney toxicity. The presently used method based on VH was not sensitive enough to be used as kidney toxicity marker. Further studies on mice are ongoing to

  13. In Vitro comparison of 213Bi- and 177Lu-radiation for peptide receptor radionuclide therapy.

    Science.gov (United States)

    Chan, Ho Sze; de Blois, Erik; Morgenstern, Alfred; Bruchertseifer, Frank; de Jong, Marion; Breeman, Wouter; Konijnenberg, Mark

    2017-01-01

    Absorbed doses for α-emitters are different from those for β-emitters, as the high linear energy transfer (LET) nature of α-particles results in a very dense energy deposition over a relatively short path length near the point of emission. This highly localized and therefore high energy deposition can lead to enhanced cell-killing effects at absorbed doses that are non-lethal in low-LET type of exposure. Affinities of DOTA-DPhe1-Tyr3-octreotate (DOTATATE), 115In-DOTATATE, 175Lu-DOTATATE and 209Bi-DOTATATE were determined in the K562-SST2 cell line. Two other cell lines were used for radiation response assessment; BON and CA20948, with a low and high expression of somatostatin receptors, respectively. Cellular uptake kinetics of 111In-DOTATATE were determined in CA20948 cells. CA20948 and BON were irradiated with 137Cs, 177Lu-DTPA, 177Lu-DOTATATE, 213Bi-DTPA and 213Bi-DOTATATE. Absorbed doses were calculated using the MIRDcell dosimetry method for the specific binding and a Monte Carlo model of a cylindrical 6-well plate geometry for the exposure by the radioactive incubation medium. Absorbed doses were compared to conventional irradiation of cells with 137Cs and the relative biological effect (RBE) at 10% survival was calculated. IC50 of (labelled) DOTATATE was in the nM range. Absorbed doses up to 7 Gy were obtained by 5.2 MBq 213Bi-DOTATATE, in majority the dose was caused by α-particle radiation. Cellular internalization determined with 111In-DOTATATE showed a linear relation with incubation time. Cell survival after exposure of 213Bi-DTPA and 213Bi-DOTATATE to BON or CA20948 cells showed a linear-exponential relation with the absorbed dose, confirming the high LET character of 213Bi. The survival of CA20948 after exposure to 177Lu-DOTATATE and the reference 137Cs irradiation showed the typical curvature of the linear-quadratic model. 10% Cell survival of CA20948 was reached at 3 Gy with 213Bi-DOTATATE, a factor 6 lower than the 18 Gy found for 177Lu

  14. In Vitro comparison of 213Bi- and 177Lu-radiation for peptide receptor radionuclide therapy.

    Directory of Open Access Journals (Sweden)

    Ho Sze Chan

    Full Text Available Absorbed doses for α-emitters are different from those for β-emitters, as the high linear energy transfer (LET nature of α-particles results in a very dense energy deposition over a relatively short path length near the point of emission. This highly localized and therefore high energy deposition can lead to enhanced cell-killing effects at absorbed doses that are non-lethal in low-LET type of exposure. Affinities of DOTA-DPhe1-Tyr3-octreotate (DOTATATE, 115In-DOTATATE, 175Lu-DOTATATE and 209Bi-DOTATATE were determined in the K562-SST2 cell line. Two other cell lines were used for radiation response assessment; BON and CA20948, with a low and high expression of somatostatin receptors, respectively. Cellular uptake kinetics of 111In-DOTATATE were determined in CA20948 cells. CA20948 and BON were irradiated with 137Cs, 177Lu-DTPA, 177Lu-DOTATATE, 213Bi-DTPA and 213Bi-DOTATATE. Absorbed doses were calculated using the MIRDcell dosimetry method for the specific binding and a Monte Carlo model of a cylindrical 6-well plate geometry for the exposure by the radioactive incubation medium. Absorbed doses were compared to conventional irradiation of cells with 137Cs and the relative biological effect (RBE at 10% survival was calculated.IC50 of (labelled DOTATATE was in the nM range. Absorbed doses up to 7 Gy were obtained by 5.2 MBq 213Bi-DOTATATE, in majority the dose was caused by α-particle radiation. Cellular internalization determined with 111In-DOTATATE showed a linear relation with incubation time. Cell survival after exposure of 213Bi-DTPA and 213Bi-DOTATATE to BON or CA20948 cells showed a linear-exponential relation with the absorbed dose, confirming the high LET character of 213Bi. The survival of CA20948 after exposure to 177Lu-DOTATATE and the reference 137Cs irradiation showed the typical curvature of the linear-quadratic model. 10% Cell survival of CA20948 was reached at 3 Gy with 213Bi-DOTATATE, a factor 6 lower than the 18 Gy found

  15. Plastic pollutants in water environment

    OpenAIRE

    Mrowiec Bożena

    2017-01-01

    Nowadays, wide applications of plastics result in plastic waste being present in the water environment in a wide variety of sizes. Plastic wastes are in water mainly as microplastics (the size range of 1 nm to < 5 mm). Microplastics have been recognized as an emerging threat, as well as ecotoxicological and ecological risk for water ecosystems. In this review are presented some of the physicochemical properties of plastic materials that determine their toxic effect on the aquatic environment....

  16. Cation sorption at the smectite edges: From transition metals to Y and Lu

    International Nuclear Information System (INIS)

    Schlegel, M.L.

    2007-01-01

    Complete text of publication follows: Introduction: Clay minerals can adsorb trace elements in soils and weathering formations, a sorption property which is also a key-point for the use of clay materials in nuclear waste repositories. Retention can occur either by adsorption on the clay basal plane or at the layer edges, depending on physicochemical conditions. Building on previous identification of sorption sites of transition metals [1-3], this study shows how the geometry of Y and Lu surface complexes on layer edges of clay minerals can be identified. Materials and methods: Suspensions of purified clay minerals (hectorite or Al-montmorillonite, 2 and 1 g/L, respectively) were reacted in 0.5 M NaCl at pH 6 (Al-montmorillonite) and 7 (hectorite) with sorbates at concentrations of 50 μM (Y) and 100 μM (Lu). Self-supporting films of reacted clay minerals were obtained by slowly filtering suspension aliquots on cellulose nitrate filters. Yttrium K-edge and Lu L3-edge polarized EXAFS (PEXAFS) spectra of the self-supporting films were collected in fluorescence mode on the FAME beamline (ESRF, France). PEXAFS data were reduced, and analyzed using standard procedures. Results and interpretation: Small but significant angular dependences were observed for all P-EXAFS data, meaning that the Y and Lu binding environments are anisotropic. Coordination spheres of 7 O at 2.36 Angstroms and 8 O at 2.27 Angstroms, were observed for Y and Lu, respectively, comparable with d(Ln-O) distances measured by EXAFS spectroscopy [4]. Lutetium sorbed on Al-montmorillonite was surrounded by an Al-shell at 3.35 Angstroms, consistent with Lu sharing edges with Al octahedra and partially incorporated in a gibbsite-like interlayer. Both Y and Lu sorbed on hectorite were surrounded by cationic shells. Modelling of these cationic contributions yielded one out-of-plane Si/Mg shell at 3.16 Angstroms (Y) or 3.04 Angstroms (Lu), and two in-plane (Mg/Si) shells at 3.50, and 3.97 Angstroms for Y, or

  17. Cation sorption at the smectite edges: From transition metals to Y and Lu

    Energy Technology Data Exchange (ETDEWEB)

    Schlegel, M.L. [CEA/DANS/DPC/SCP Lab React Surfaces and Interfaces, F-91191 Gif Sur Yvette (France)

    2007-07-01

    Complete text of publication follows: Introduction: Clay minerals can adsorb trace elements in soils and weathering formations, a sorption property which is also a key-point for the use of clay materials in nuclear waste repositories. Retention can occur either by adsorption on the clay basal plane or at the layer edges, depending on physicochemical conditions. Building on previous identification of sorption sites of transition metals [1-3], this study shows how the geometry of Y and Lu surface complexes on layer edges of clay minerals can be identified. Materials and methods: Suspensions of purified clay minerals (hectorite or Al-montmorillonite, 2 and 1 g/L, respectively) were reacted in 0.5 M NaCl at pH 6 (Al-montmorillonite) and 7 (hectorite) with sorbates at concentrations of 50 {mu}M (Y) and 100 {mu}M (Lu). Self-supporting films of reacted clay minerals were obtained by slowly filtering suspension aliquots on cellulose nitrate filters. Yttrium K-edge and Lu L3-edge polarized EXAFS (PEXAFS) spectra of the self-supporting films were collected in fluorescence mode on the FAME beamline (ESRF, France). PEXAFS data were reduced, and analyzed using standard procedures. Results and interpretation: Small but significant angular dependences were observed for all P-EXAFS data, meaning that the Y and Lu binding environments are anisotropic. Coordination spheres of 7 O at 2.36 Angstroms and 8 O at 2.27 Angstroms, were observed for Y and Lu, respectively, comparable with d(Ln-O) distances measured by EXAFS spectroscopy [4]. Lutetium sorbed on Al-montmorillonite was surrounded by an Al-shell at 3.35 Angstroms, consistent with Lu sharing edges with Al octahedra and partially incorporated in a gibbsite-like interlayer. Both Y and Lu sorbed on hectorite were surrounded by cationic shells. Modelling of these cationic contributions yielded one out-of-plane Si/Mg shell at 3.16 Angstroms (Y) or 3.04 Angstroms (Lu), and two in-plane (Mg/Si) shells at 3.50, and 3.97 Angstroms for Y

  18. Phase stabilization in transparent Lu2O3:Eu ceramics by lattice expansion

    Science.gov (United States)

    Seeley, Z. M.; Dai, Z. R.; Kuntz, J. D.; Cherepy, N. J.; Payne, S. A.

    2012-11-01

    Gadolinium lutetium oxide transparent ceramics doped with europium (Gd,Lu)2O3:Eu were fabricated via vacuum sintering and hot isostatic pressing (HIP). Nano-scale starting powder with the composition GdxLu1.9-xEu0.1O3 (x = 0, 0.3, 0.6, 0.9, 1.0, and 1.1) were uniaxially pressed and sintered under high vacuum at 1625 °C to obtain ˜97% dense structures with closed porosity. Sintered compacts were then subjected to 200 MPa argon gas at temperatures between 1750 and 1900 °C to reach full density. It was observed that a small portion of the Eu3+ ions were exsolved from the Lu2O3 cubic crystal lattice and concentrated at the grain boundaries, where they precipitated into a secondary monoclinic phase creating optical scattering defects. Addition of Gd3+ ions into the Lu2O3 cubic lattice formed the solid solution (Gd,Lu)2O3:Eu and stretched the lattice parameter allowing the larger Eu3+ ions to stay in solid solution, reducing the secondary phase and improving the transparency of the ceramics. Excess gadolinium, however, resulted in a complete phase transformation to monoclinic at pressures and temperatures sufficient for densification. Light yield performance was measured and all samples show equal amounts of the characteristic Eu3+ luminescence, indicating gadolinium addition had no adverse effect. This material has potential to improve the performance of high energy radiography devices.

  19. Crystal growth, spectroscopic and CW laser properties of Nd0.03Lu2.871Gd0.099Al5O12 crystal

    Science.gov (United States)

    Di, J. Q.; Xu, X. D.; Cheng, S. S.; Li, D. Z.; Zhou, D. H.; Wu, F.; Zhao, Z. W.; Xu, J.

    2011-11-01

    Nd0.03Lu2.871Gd0.099Al5O12 (Nd:LuGdAG) crystal was grown by the Czochralski method. The absorption, fluorescence spectra and fluorescence lifetime of Nd:LuGdAG crystal at room temperature were investigated for the first time. We reported the continuous-wave (CW) Nd:LuGdAG laser operation under diode pumping. Output power of 1.43 W at 1064 nm was achieved with a slope efficiency of 34.1%. All the results show that Nd:LuGdAG crystal is a promising laser material.

  20. Effect of Gd substitution on structure and spectroscopic properties of (Lu,Gd)2O3:Eu ceramic scintillator

    Science.gov (United States)

    Cao, Maoqing; Hu, Zewang; Ivanov, Maxim; Dai, Jiawei; Li, Chaoyu; Kou, Huamin; Shi, Yun; Chen, Haohong; Xu, Jiayue; Pan, Yubai; Li, Jiang

    2018-02-01

    In this paper, (Lu1-xGdx)2O3:Eu (x = 0, 0.1, 0.3, 0.5, 0.7, 0.9) ceramics were consolidated by the solid-state reaction method combined with vacuum sintering without sintering aids. We investigated the effect of the varying contents of Gd2O3 on the structure and spectroscopic properties of (Lu1-xGdx)2O3:Eu ceramics. X-ray diffraction (XRD) patterns indicate that proper amount of Gd2O3 can incorporate well with Lu2O3 and form Lu2O3-Gd2O3 solid solution. However, excessive Gd3+-doping in Lu2O3 will lead to the cubic phase transforming into monoclinic even hexagonal phase. The Gd3+ substitution no more than 50% of Lu2O3 enhances the radioluminescence, and reduces the fluorescence lifetime. Transmittance, photoluminescence, and radiation damage of the (Lu1-xGdx)2O3:Eu scintillation ceramics were also studied.

  1. Introduction to Computational Plasticity

    International Nuclear Information System (INIS)

    Hartley, P

    2006-01-01

    The focus of the book on computational plasticity embodies techniques of relevance not only to academic researchers, but also of interest to industrialists engaged in the production of components using bulk or sheet forming processes. Of particular interest is the guidance on how to create modules for use with the commercial system Abaqus for specific types of material behaviour. The book is in two parts, the first of which contains six chapters, starting with microplasticity, but predominantly on continuum plasticity. The first chapter on microplasticty gives a brief description of the grain structure of metals and the existence of slip systems within the grains. This provides an introduction to the concept of incompressibility during plastic deformation, the nature of plastic yield and the importance of the critically resolved shear stress on the slip planes (Schmid's law). Some knowledge of the notation commonly used to describe slip systems is assumed, which will be familiar to students of metallurgy, but anyone with a more general engineering background may need to undertake additional reading to understand the various descriptions. Chapter two introduces one of several yield criteria, that normally attributed to von Mises (though historians of mechanics might argue over who was first to develop the theory of yielding associated with strain energy density), and its two or three-dimensional representation as a yield surface. The expansion of the yield surface during plastic deformation, its translation due to kinematic hardening and the Bauschinger effect in reversed loading are described with a direct link to the material stress-strain curve. The assumption, that the increment of strain is normal to the yield surface, the normality principle, is introduced. Uniaxial loading of an elastic-plastic material is used as an example in which to develop expressions to describe increments in stress and strain. The full presentation of numerous expressions, tensors and

  2. Plasticity modeling & computation

    CERN Document Server

    Borja, Ronaldo I

    2013-01-01

    There have been many excellent books written on the subject of plastic deformation in solids, but rarely can one find a textbook on this subject. “Plasticity Modeling & Computation” is a textbook written specifically for students who want to learn the theoretical, mathematical, and computational aspects of inelastic deformation in solids. It adopts a simple narrative style that is not mathematically overbearing, and has been written to emulate a professor giving a lecture on this subject inside a classroom. Each section is written to provide a balance between the relevant equations and the explanations behind them. Where relevant, sections end with one or more exercises designed to reinforce the understanding of the “lecture.” Color figures enhance the presentation and make the book very pleasant to read. For professors planning to use this textbook for their classes, the contents are sufficient for Parts A and B that can be taught in sequence over a period of two semesters or quarters.

  3. Sub-nanosecond plastic scintillators

    International Nuclear Information System (INIS)

    Lyons, P.B.; Caldwell, S.E.; Hocker, L.P.; Crandall, D.G.; Zagarino, P.A.; Cheng, J.; Tirsell, G.; Hurlbut, C.R.

    1977-01-01

    Quenched plastic scintillators have been developed that yield much faster short decay components and greatly reduced long decay components compared to conventional plastic scintillators. The plastics are produced through the addition of selected quench agents to NE111 plastic scintillator that result in reduced total light output. Eight different agents have been studied. Benzophenone and piperidine are two of the most effective quench agents. Data are presented both for short and long decay components. The plastics are expected to make significant contributions in areas of plasma diagnostics

  4. Sub-nanosecond plastic scintillators

    International Nuclear Information System (INIS)

    Lyons, P.B.; Caldwell, S.E.; Hocker, L.P.; Crandall, D.G.; Zagarino, P.A.; Cheng, J.; Tirsell, G.; Hurlbut, C.R.

    1976-01-01

    Quenched plastic scintillators have been developed that yield much faster short decay components and greatly reduced long decay components compared to conventional plastic scintillators. The plastics are produced through the addition of selected quench agents to NE111 plastic scintillator that result in reduced total light output. Eight different agents have been studied. Benzophenone and piperidine are two of the most effective quench agents. Data are presented both for short and long decay components. The plastics are expected to make significant contributions in areas of plasma diagnostics

  5. Compensatory plasticity: time matters

    Directory of Open Access Journals (Sweden)

    Latifa eLazzouni

    2014-06-01

    Full Text Available Plasticity in the human and animal brain is the rule, the base for development, and the way to deal effectively with the environment for making the most efficient use of all the senses. When the brain is deprived of one sensory modality, plasticity becomes compensatory: the exception that invalidates the general loss hypothesis giving the opportunity of effective change. Sensory deprivation comes with massive alterations in brain structure and function, behavioural outcomes, and neural interactions. Blind individuals do as good as the sighted and even more, show superior abilities in auditory, tactile and olfactory processing. This behavioural enhancement is accompanied with changes in occipital cortex function, where visual areas at different levels become responsive to non-visual information. The intact senses are in general used more efficiently in the blind but are also used more exclusively. New findings are disentangling these two aspects of compensatory plasticity. What is due to visual deprivation and what is dependent on the extended use of spared modalities? The latter seems to contribute highly to compensatory changes in the congenitally blind. Short term deprivation through the use of blindfolds shows that cortical excitability of the visual cortex is likely to show rapid modulatory changes after few minutes of light deprivation and therefore changes are possible in adulthood. However, reorganization remains more pronounced in the congenitally blind. Cortico-cortical pathways between visual areas and the areas of preserved sensory modalities are inhibited in the presence of vision, but are unmasked after loss of vision or blindfolding as a mechanism likely to drive cross-modal information to the deafferented visual cortex. Plasticity in the blind is also accompanied with neurochemical and morphological changes; both intrinsic connectivity and functional coupling at rest are altered but are likewise dependent on different sensory

  6. Mesocycles in conserving plastics

    DEFF Research Database (Denmark)

    Shashoua, Yvonne

    2016-01-01

    driven by the need to balance the requirements for reversibility in conservation practices with the artist’s intent and significance. Developments within each of the three mesocycles from the 1990s to date are discussed in this article. Environmental science and toxicology of waste plastics offer a novel...... source of information about real time degradation in terrestrial and marine microenvironments that seems likely to contribute to the conservation of similar materials in contemporary artworks....

  7. Ln3+ (Ln=Ce, Tb, Dy) and Hf doping of LuI3 powders – A material and spectroscopic study

    International Nuclear Information System (INIS)

    Wiatrowska, Aneta; Keur, Wilco; Ronda, Cees

    2016-01-01

    The moisture sensitivity of LuI 3 :Ce,Hf and luminescent properties of undoped LuI 3 and LuI 3 :M (M=Ce 3+ , Tb 3+ , Dy 3+ ) powders were investigated. The possibility of improving the air and moisture stability of LuI 3 :Ce by Hf doping was tested. It was proven that the Hf contribution to the LuI 3 :Ce stability is very limited and is insignificant to render LuI 3 :Ce scintillator powders suitable for applications. Photoluminescence results of LuI 3 without dopants added on purpose showed luminescence due to a plurality of rare-earth elements' impurities. Two types of self-trapped luminescence were found. Energy transfer between host lattice, self-trapped excitons and rare-earth ions was investigated.

  8. Composition and local bonding in RE-Si-M-O-N (M=Mg, Al ; RE=La, Lu) glasses

    Energy Technology Data Exchange (ETDEWEB)

    Fouquet-Parry, V. [Service de Physique et de Chimie des Surfaces et des Interfaces, DSM/DRECAM/SPCSI, CEA Saclay, 91191 Gif sur Yvette Cedex (France); Paumier, F. [Laboratoire de Metallurgie Physique - UMR 6630 CNRS, Department of Materials Sciences, University of Poitiers (France); Guittet, M.J. [Service de Physique et de Chimie des Surfaces et des Interfaces, DSM/DRECAM/SPCSI, CEA Saclay, 91191 Gif sur Yvette Cedex (France); Gautier-Soyer, M. [Service de Physique et de Chimie des Surfaces et des Interfaces, DSM/DRECAM/SPCSI, CEA Saclay, 91191 Gif sur Yvette Cedex (France)], E-mail: mgautiersoyer@cea.fr; Satet, R.; Hoffmann, M.J. [Institut fuer Keramik im Maschinenbau, Universitaet Karlsruhe (Thailand), Haid-und-Neu-Strasse 7, D 76131 Karlsruhe (Germany); Becher, P.F.; Painter, G.S. [Metals and Ceramics Division, Oak Ridge National Laboratory, Oak Ridge, TN (United States)

    2008-05-30

    Two series of oxynitride glasses, RE-Si-Mg-O-N (M=Mg, Al ; RE=La, Lu), have been studied by X-Ray photoelectron spectroscopy (XPS). The oxygen 1s photoelectron lineshape reveals a striking difference depending on the rare earth, both in the Mg series and in the Al series. Specifically, the oxygen 1s photoelectron lines of the La doped glasses are broader than the ones of the Lu doped glasses. This result is an experimental evidence that Lu has a larger affinity for oxygen versus nitrogen than La, as theoretically predicted by the first-principles calculations by Painter et al.

  9. Plastic footwear for leprosy.

    Science.gov (United States)

    Antia, N H

    1990-03-01

    The anaesthetic foot in leprosy poses the most major problem in the rehabilitation of its patients. Various attempts have been made to produce protective footwear such as the microcellular rubber-car-tyre sandals. Unfortunately these attempts have had little success on a large scale because of the inability to produce them in large numbers and the stigma attached to such unusual footwear. While such footwear may be superior to the 'tennis' shoe in protecting the foot from injury by the penetration of sharp objects, it fails to distribute the weight-bearing forces which is the major cause of plantar damage and ulceration in the anaesthetic foot. This can be achieved by providing rigidity to the sole, as demonstrated by the healing of ulcers in plaster of paris casts or the rigid wooden clog. A new type of moulded plastic footwear has been evolved in conjunction with the plastic footwear industry which provides footwear that can be mass produced at a low price and which overcomes the stigma of leprosy. Controlled rigidity is provided by the incorporation of a spring steel shank between the sponge insole and the hard wearing plastic sole. Trials have demonstrated both the acceptability of the footwear and its protective effects as well as its hard wearing properties.

  10. Plastic waste disposal apparatus

    Energy Technology Data Exchange (ETDEWEB)

    Kito, S

    1972-05-01

    A test plant plastic incinerator was constructed by the Takuma Boiler Manufacturing Co. for Sekisui Chemical Industries, and the use of a continuous feed spreader was found to be most effective for prevention of black smoke, and the use of a venturi scrubber proved to be effective for elimination of hydrogen chloride gas. The incinerator was designed for combustion of polyvinyl chloride exclusively, but it is also applicable for combustion of other plastics. When burning polyethylene, polypropylene, or polystyrene, (those plastics which do not produce toxic gases), the incinerator requires no scrubber for the combustion gas. The system may or may not have a pretreatment apparatus. For an incinerator with a pretreatment system, the flow chart comprises a pit, a supply crane, a vibration feeder, a metal eliminator, a rotation shredder, a continuous screw feeder with a quantitative supply hopper, a pretreatment chamber (300 C dry distillation), a quantitative supply hopper, and the incinerator. The incinerator is a flat non-grid type combustion chamber with an oil burner and many air nozzles. From the incinerator, ashes are sent by an ash conveyor to an ash bunker. The combustion gas goes to the boiler, and the water supplied the boiler water pump creates steam. The heat from the gas is sent back to the pretreatment system through a heat exchanger. The gas then goes to a venturi scrubber and goes out from a stack.

  11. New perspectives in plastic biodegradation.

    Science.gov (United States)

    Sivan, Alex

    2011-06-01

    During the past 50 years new plastic materials, in various applications, have gradually replaced the traditional metal, wood, leather materials. Ironically, the most preferred property of plastics--durability--exerts also the major environmental threat. Recycling has practically failed to provide a safe solution for disposal of plastic waste (only 5% out of 1 trillion plastic bags, annually produced in the US alone, are being recycled). Since the most utilized plastic is polyethylene (PE; ca. 140 million tons/year), any reduction in the accumulation of PE waste alone would have a major impact on the overall reduction of the plastic waste in the environment. Since PE is considered to be practically inert, efforts were made to isolate unique microorganisms capable of utilizing synthetic polymers. Recent data showed that biodegradation of plastic waste with selected microbial strains became a viable solution. Copyright © 2011 Elsevier Ltd. All rights reserved.

  12. Performance of molded plastic scintillators

    International Nuclear Information System (INIS)

    Gen, N.S.; Leman, V.E.; Solomonov, V.M.

    1989-01-01

    The performance of molded plastic scintillators is studied. The plastic scintillators studied were formed by transfer molding and intrusion from a scintillation composition consisting of polystyrene and a standard system of luminescent additives: 2 mass % of paraterphenyl + 0.06 mass % 1,4-di-/2-[5-phenyloxazoyly]/benzene and a plasticizer. The combined effect of mechanical load and temperature was studied. The effect of radiation on molded plastic scintillators was studied using gamma radiation from a 60 Co source. The studies show that the main operating characteristics of molded plastic scintillators are on a par with those of polymerized plastic scintillators. At the same time, molded plastic scintillators are superior in thermal stability at temperatures below the glass transition temperature and with respect to their working temperature range

  13. Zile Elbaşoğlu Camii’nin Sıvalar Altında Kalan Gizemi The Mystery Of The Zile-Elbaşoğlu Mosque Remains Under Plasters

    Directory of Open Access Journals (Sweden)

    Ali Murat AKTEMUR

    2013-09-01

    Full Text Available Elbaşoğlu Mosque was built in 1801 by Ahmet Aga, clean-cutstone architecture, square, rectangular with remarkable inscriptionsElbaşoğlu Mosque is one of the local mosque, wood-backed and woodenceilings. Until 2007, the walls and the ceiling, and even the altar,wooden support, wood columns, wooden gallery, galleries, in short, allthe wooden elements of the mosque was covered with oil on sweet-limeplaster. In 2007, during the repair of the roof of a simple chance, withplaster falling due to the flowing water under the pen-and-repair workon the emergence of ornaments and wooden decorations samples, thenstopped cleaning and scraper operations in the administration of theGeneral Directorate of Foundations in the interior of the mosque penrichsamples of work, with examples of wooden decorative plaster underthe mystery was revealed.Cover at the top of the walls combined with Harim calligraphy ona black background with spots, including a concave border of the beltframed verse was written. Verse generation raised on the corners of theceiling moldings created crash of beads, triangle, octagon in the middleof a field, and thus created the split surfaces. Located in the middle ofthe octagon octagon-shaped belly, finished with carving technique,baroque decorated with floral motifs. the four corners of the triangularroof panels are decorated with reliefs excess plastic plant. Pen-workdecoration floral motifs on the walls, gallery, pulpits, pillars, such asthe carved wooden elements fall floral and geometric motifs are carvedin the mosque offers a wealth of eye-catching as almost free space left.Made in 1801, in the early years of the Republic, the region'sunique sweet-lime paint on plaster taken off this rich decoration, woodart and pen-work ornamentation Turkey offers one of the richest. Tokat Zile’de Elbaşoğlu Ahmet Ağa tarafından 1801 yılında inşa ettirilen, düzgün kesme taş mimarisi, kitabeleri ile dikkat çeken, kareye yakın dikd

  14. Electrochemistry and spectroelectrochemistry of tert-butylcalix[4]arene bridged bis double-decker lutetium(III) phthalocyanine, Lu2Pc4 and dimeric lutetium(III) phthalocyanine, Lu2Pc2(OAc)2

    International Nuclear Information System (INIS)

    Koca, Atif; Ceyhan, Tanju; Erbil, Mehmet K.; Ozkaya, Ali Riza; Bekaroglu, Ozer

    2007-01-01

    In this study, electrochemical, electrochromic and spectroelectrochemical properties of a tert-butylcalix[4]arene bridged bis double-decker lutetium(III) phthalocyanine (Lu 2 Pc 4 2) were investigated explicitly as compared with a tert-butylcalix[4]arene bridged dimeric lutetium(III) phthalocyanine [Lu 2 Pc 2 (OAc) 2 1]. Distinctive differences between electrochemical and electrochromic properties of 1 and 2 were detected. Moreover, the properties of 1 and 2 were compared with previously reported S 4 (CH 2 ) 4 bridged Lu 2 Pc 2 (OAc) 2 and Lu 2 Pc 4 . The calixarene bridged phthalocyanine (Pc) compounds, 1 and 2 showed well-defined electrochromic behaviour with green-blue and blue-purple colour transitions. The enhanced electrochromic properties of 2, as compared to 1, were attributed to its double-decker structure, probably allowing the formation of suitable ion channels for the counter ion movement in the solid film

  15. Effect of reducing Lu.sup.3+./sup. content on the fabrication and scintillation properties of non-stoichiometric Lu.sub.3-x./sub.Al.sub.5./sub.O.sub.12./sub.:Ce ceramics

    Czech Academy of Sciences Publication Activity Database

    Liu, S.; Mareš, Jiří A.; Babin, Vladimir; Hu, C.; Kou, H.; D'Ambrosio, C.; Pan, Y.; Nikl, Martin

    2017-01-01

    Roč. 63, Jan-Sl (2017), s. 179-184 ISSN 0925-3467 R&D Projects: GA ČR GAP204/12/0805 Institutional support: RVO:68378271 Keywords : LuAG:Ce ceramics * Lu 3+ deficiency * scintillation light yield * non-stoichiometry * antisite defects Subject RIV: BM - Solid Matter Physics ; Magnetism OBOR OECD: Condensed matter physics (including formerly solid state physics, supercond.) Impact factor: 2.238, year: 2016

  16. Plastics in the Marine Environment.

    Science.gov (United States)

    Law, Kara Lavender

    2017-01-03

    Plastics contamination in the marine environment was first reported nearly 50 years ago, less than two decades after the rise of commercial plastics production, when less than 50 million metric tons were produced per year. In 2014, global plastics production surpassed 300 million metric tons per year. Plastic debris has been detected worldwide in all major marine habitats, in sizes from microns to meters. In response, concerns about risks to marine wildlife upon exposure to the varied forms of plastic debris have increased, stimulating new research into the extent and consequences of plastics contamination in the marine environment. Here, I present a framework to evaluate the current understanding of the sources, distribution, fate, and impacts of marine plastics. Despite remaining knowledge gaps in mass budgeting and challenges in investigating ecological impacts, the increasing evidence of the ubiquity of plastics contamination in the marine environment, the continued rapid growth in plastics production, and the evidence-albeit limited-of demonstrated impacts to marine wildlife support immediate implementation of source-reducing measures to decrease the potential risks of plastics in the marine ecosystem.

  17. Plastics in the Marine Environment

    Science.gov (United States)

    Law, Kara Lavender

    2017-01-01

    Plastics contamination in the marine environment was first reported nearly 50 years ago, less than two decades after the rise of commercial plastics production, when less than 50 million metric tons were produced per year. In 2014, global plastics production surpassed 300 million metric tons per year. Plastic debris has been detected worldwide in all major marine habitats, in sizes from microns to meters. In response, concerns about risks to marine wildlife upon exposure to the varied forms of plastic debris have increased, stimulating new research into the extent and consequences of plastics contamination in the marine environment. Here, I present a framework to evaluate the current understanding of the sources, distribution, fate, and impacts of marine plastics. Despite remaining knowledge gaps in mass budgeting and challenges in investigating ecological impacts, the increasing evidence of the ubiquity of plastics contamination in the marine environment, the continued rapid growth in plastics production, and the evidence—albeit limited—of demonstrated impacts to marine wildlife support immediate implementation of source-reducing measures to decrease the potential risks of plastics in the marine ecosystem.

  18. Abiotic degradation of plastic films

    Science.gov (United States)

    Ángeles-López, Y. G.; Gutiérrez-Mayen, A. M.; Velasco-Pérez, M.; Beltrán-Villavicencio, M.; Vázquez-Morillas, A.; Cano-Blanco, M.

    2017-01-01

    Degradable plastics have been promoted as an option to mitigate the environmental impacts of plastic waste. However, there is no certainty about its degradability under different environmental conditions. The effect of accelerated weathering (AW), natural weathering (NW) and thermal oxidation (TO) on different plastics (high density polyethylene, HDPE; oxodegradable high density polyethylene, HDPE-oxo; compostable plastic, Ecovio ® metalized polypropylene, PP; and oxodegradable metalized polypropylene, PP-oxo) was studied. Plastics films were exposed to AW per 110 hours; to NW per 90 days; and to TO per 30 days. Plastic films exposed to AW and NW showed a general loss on mechanical properties. The highest reduction in elongation at break on AW occurred to HDPE-oxo (from 400.4% to 20.9%) and was higher than 90% for HDPE, HDPE-oxo, Ecovio ® and PP-oxo in NW. No substantial evidence of degradation was found on plastics exposed to TO. Oxo-plastics showed higher degradation rates than their conventional counterparts, and the compostable plastic was resistant to degradation in the studied abiotic conditions. This study shows that degradation of plastics in real life conditions will vary depending in both, their composition and the environment.

  19. The Lu-Hf isotope composition of cratonic lithosphere: disequilibrium between garnet and clinopyroxene in kimberlite xenoliths

    NARCIS (Netherlands)

    Simon, N.S.C.; Carlson, R.W.; Pearson, D.G.; Davies, G.R.

    2002-01-01

    12th Annual V.M. Goldschmidt Conference Davos Switzerland, The Lu-Hf isotope composition of cratonic lithosphere: disequilibrium between garnet and clinopyroxene in kimberlite xenoliths (DTM, Carnegie Institution of Washington), Pearson, D.G. (University of Durham)

  20. Potentiometric and spectral studies of complex formation of La(3), Pr(3) and Lu(3) with aspartic acid and asparagine

    International Nuclear Information System (INIS)

    Wojciechowska, A.; Lomozik, L.; Zielinski, S.

    1987-01-01

    The composition and stability of La 3+ , Pr 3+ and Lu 3+ complexes with aspartic acid and asparagine were analysed. The formation of complexes of the type ML and MHL was determined for La 3+ and Pr 3+ with aspartic acid, and of the type MHL for Lu 3+ with aspartic acid. For La 3+ , Pr 3+ and Lu 3+ with asparagine the formation of ML(OH) complexes was observed. By means of 1 HNMR and 13 CNMR studies the participation in the coordination of both -COOH groups was determined for aspartic acid, whereas for asparagine the participation of the -COOH group was determined in complexes with La 3+ , Pr 3+ , and of the -COOH and the -NH 2 groups in the complex with Lu 3+ . (Author)

  1. Development of a therapeutic radiopharmaceutical {sup 177}Lu-DOTA- Minigastrin for potential use in PRRT; Desarrollo de un radiofarmaco terapeutico {sup 177}Lu-DOTA-Minigastrina para su potencial uso en PRRT

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Bularte, A. C.; Nevares, N. N.; Zapata, A. M.; Perez, J. H.; Crudo, J. L. [Comision Nacional de Energia Atomica (Argentina); Puerta Yepes, N.; Rojo, A. M. [Autoridad Regulatoria Nuclear (Argentina)

    2010-07-01

    The aim of this work is to obtain {sup 177}Lu-DOTA-Minigastrin with high radiochemical purity (RP) and the highest specific activity (Ae) as possible, using a locally produced (Nuclear Reactor RA-3, Ezeiza Atomic Center) {sup 177}LuCl{sub 3} of an intermediate level of Ae (between 6.36 to 17.95 Ci/mg of {sup 176}Lu) ) and also to perform in vitro and in vivo stability tests, dose calculation in normal mice and its extrapolation to a human model. (authors) [Spanish] El objetivo de este trabajo consistio en obtener {sup 177}Lu-DOTA-Minigastrina con una alta pureza radioquimica (PR) y la mayor actividad especifica (Ae) posible, empleando {sup 177}LuCl{sub 3} de media Ae (entre 6,36-17,95 Ci/mg de {sup 176}Lu) de produccion local (Reactor Nuclear RA-3, Centro Atomico Ezeiza), y realizar los ensayos de estabilidad in vitro e in vivo, el calculo de dosis en ratones normales y su extrapolacion a un modelo humano. (autores)

  2. Comparative study of optical and scintillation properties of YVO{sub 4}, (Lu{sub 0.5}Y{sub 0.5})VO{sub 4}, and LuVO{sub 4} single crystals

    Energy Technology Data Exchange (ETDEWEB)

    Fujimoto, Yutaka, E-mail: fuji-you@tagen.tohoku.ac.j [IMRAM, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Yanagida, Takayuki; Yokota, Yuui; Chani, Valery [IMRAM, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); Kochurikhin, Vladimir V. [General Physics Institute, 38 Vavilov Street, 119991, Federation, Moscow (Russian Federation); Yoshikawa, Akira [IMRAM, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577 (Japan); NICHe, Tohoku University, 6-6-10 Aoba, Aramaki, Aoba-ku, Sendai 980-8579 (Japan)

    2011-04-11

    Optical and scintillation properties of YVO{sub 4}, (Lu{sub 0.5}Y{sub 0.5})VO{sub 4}, and LuVO{sub 4} single crystals grown by the Czochralski (CZ) method with RF heating system are compared. All vanadate crystals show high transmittance ({approx}80%) in the 400-900 nm wavelength range. In both photo- and radio-luminescence spectra, intense peak around 400-500 nm, which was ascribed to the transition from triplet state of VO{sub 4}{sup 3-}, was clearly observed. The main decay time component was about 38 {mu}s (YVO{sub 4}), 18 {mu}s ((Lu{sub 0.5}Y{sub 0.5})VO{sub 4}), and 17 {mu}s (LuVO{sub 4}) under 340 nm excitation. The scintillation light yields of YVO{sub 4}, (Lu{sub 0.5}Y{sub 0.5})VO{sub 4}, and LuVO{sub 4} crystals (obtained from the {sup 137}Cs excited pulse height spectra) were evaluated to be about 11,200, 10,700, and 10,300 ph/MeV, respectively.

  3. Direct liquefaction of plastics and coprocessing of coal with plastics

    Energy Technology Data Exchange (ETDEWEB)

    Huffman, G.P.; Feng, Z.; Mahajan, V. [Univ. of Kentucky, Lexington, KY (United States)

    1995-12-31

    The objectives of this work were to optimize reaction conditions for the direct liquefaction of waste plastics and the coprocessing of coal with waste plastics. In previous work, the direct liquefaction of medium and high density polyethylene (PE), polypropylene (PPE), poly(ethylene terephthalate) (PET), and a mixed plastic waste, and the coliquefaction of these plastics with coals of three different ranks was studied. The results established that a solid acid catalyst (HZSM-5 zeolite) was highly active for the liquefaction of the plastics alone, typically giving oil yields of 80-95% and total conversions of 90-100% at temperatures of 430-450 {degrees}C. In the coliquefaction experiments, 50:50 mixtures of plastic and coal were used with a tetralin solvent (tetralin:solid = 3:2). Using approximately 1% of the HZSM-5 catalyst and a nanoscale iron catalyst, oil yields of 50-70% and total conversion of 80-90% were typical. In the current year, further investigations were conducted of the liquefaction of PE, PPE, and a commingled waste plastic obtained from the American Plastics Council (APC), and the coprocessing of PE, PPE and the APC plastic with Black Thunder subbituminous coal. Several different catalysts were used in these studies.

  4. Plastics pipe couplings

    International Nuclear Information System (INIS)

    Glover, J.B.

    1980-07-01

    A method is described of making a pipe coupling of the type comprising a plastics socket and a resilient annular sealing member secured in the mouth thereof, in which the material of at least one component of the coupling is subjected to irradiation with high energy radiation whereby the material is caused to undergo cross-linking. As examples, the coupling may comprise a polyethylene or plasticised PVC socket the material of which is subjected to irradiation, and the sealing member may be moulded from a thermoplastic elastomer which is subjected to irradiation. (U.K.)

  5. Somatostatin-based radiopeptide therapy with [177Lu-DOTA]-TOC versus [90Y-DOTA]-TOC in neuroendocrine tumours

    International Nuclear Information System (INIS)

    Romer, A.; Seiler, D.; Brunner, P.; Ng, Q.K.T.; Mueller-Brand, J.; Marincek, N.; Walter, M.A.; Koller, M.T.; Maecke, H.R.; Rochlitz, C.; Briel, M.; Schindler, C.

    2014-01-01

    Somatostatin-based radiopeptide treatment is generally performed using the β-emitting radionuclides 90 Y or 177 Lu. The present study aimed at comparing benefits and harms of both therapeutic approaches. In a comparative cohort study, patients with advanced neuroendocrine tumours underwent repeated cycles of [ 90 Y-DOTA]-TOC or [ 177 Lu-DOTA]-TOC until progression of disease or permanent adverse events. Multivariable Cox regression and competing risks regression were employed to examine predictors of survival and adverse events for both treatment groups. Overall, 910 patients underwent 1,804 cycles of [ 90 Y-DOTA]-TOC and 141 patients underwent 259 cycles of [ 177 Lu-DOTA]-TOC. The median survival after [ 177 Lu-DOTA]-TOC and after [ 90 Y-DOTA]-TOC was comparable (45.5 months versus 35.9 months, hazard ratio 0.91, 95 % confidence interval 0.63-1.30, p = 0.49). Subgroup analyses revealed a significantly longer survival for [ 177 Lu-DOTA]-TOC over [ 90 Y-DOTA]-TOC in patients with low tumour uptake, solitary lesions and extra-hepatic lesions. The rate of severe transient haematotoxicities was lower after [ 177 Lu-DOTA]-TOC treatment (1.4 vs 10.1 %, p = 0.001), while the rate of severe permanent renal toxicities was similar in both treatment groups (9.2 vs 7.8 %, p = 0.32). The present results revealed no difference in median overall survival after [ 177 Lu-DOTA]-TOC and [ 90 Y-DOTA]-TOC. Furthermore, [ 177 Lu-DOTA]-TOC was less haematotoxic than [ 90 Y-DOTA]-TOC. (orig.)

  6. Somatostatin-based radiopeptide therapy with [177Lu-DOTA]-TOC versus [90Y-DOTA]-TOC in neuroendocrine tumours.

    Science.gov (United States)

    Romer, A; Seiler, D; Marincek, N; Brunner, P; Koller, M T; Ng, Q K T; Maecke, H R; Müller-Brand, J; Rochlitz, C; Briel, M; Schindler, C; Walter, M A

    2014-02-01

    Somatostatin-based radiopeptide treatment is generally performed using the β-emitting radionuclides (90)Y or (177)Lu. The present study aimed at comparing benefits and harms of both therapeutic approaches. In a comparative cohort study, patients with advanced neuroendocrine tumours underwent repeated cycles of [(90)Y-DOTA]-TOC or [(177)Lu-DOTA]-TOC until progression of disease or permanent adverse events. Multivariable Cox regression and competing risks regression were employed to examine predictors of survival and adverse events for both treatment groups. Overall, 910 patients underwent 1,804 cycles of [(90)Y-DOTA]-TOC and 141 patients underwent 259 cycles of [(177)Lu-DOTA]-TOC. The median survival after [(177)Lu-DOTA]-TOC and after [(90)Y-DOTA]-TOC was comparable (45.5 months versus 35.9 months, hazard ratio 0.91, 95% confidence interval 0.63-1.30, p = 0.49). Subgroup analyses revealed a significantly longer survival for [(177)Lu-DOTA]-TOC over [(90)Y-DOTA]-TOC in patients with low tumour uptake, solitary lesions and extra-hepatic lesions. The rate of severe transient haematotoxicities was lower after [(177)Lu-DOTA]-TOC treatment (1.4 vs 10.1%, p = 0.001), while the rate of severe permanent renal toxicities was similar in both treatment groups (9.2 vs 7.8%, p = 0.32). The present results revealed no difference in median overall survival after [(177)Lu-DOTA]-TOC and [(90)Y-DOTA]-TOC. Furthermore, [(177)Lu-DOTA]-TOC was less haematotoxic than [(90)Y-DOTA]-TOC.

  7. Internal radiotherapy and dosimetric study for 111In/177Lu-pegylated liposomes conjugates in tumor-bearing mice

    International Nuclear Information System (INIS)

    Wang, H.-E.; Yu, H.-M.; Lu, Y.-C.; Heish, N.-N.; Tseng, Yun-Long; Huang, K.-L.; Chuang, K.-T.; Chen, Chin-Hsiung; Hwang, J.-J.; Lin, W.-J.; Wang, Shyh-Jen; Ting, G.; Whang-Peng, Jacqueline; Deng, W.-P.

    2006-01-01

    In vivo characterization and dosimetric analysis has been performed to evaluate the potential of pegylated liposomes as carriers of radionuclides in tumor internal radiotherapy. Methods: The DTPA/PEG-liposomes were synthesized with a medium size of 110 nm, conjugated with 111 In/ 177 Lu-(oxine) 3 to afford 111 In/ 177 Lu-liposome. The stability of 111 In/ 177 Lu-liposome in serum was investigated. The biodistribution, scintigraphic imaging and pharmacokinetics of 111 In/ 177 Lu-liposomes after intravenous(i.v.) injection into C-26 tumor-bearing BALB/cByJ mice were studied. Radiation dose was estimated by MIRD-III program. Results: The incorporation efficiency of 111 In/ 177 Lu into liposomes was 95%. After incubation at 37 o C for 72 h in serum, more than 83% of radioactivity was still retained in the intact 111 In/ 177 Lu-liposomes. The biodistribution of 111 In-liposomes showed that the radioactivity in the blood decreased from 23.14±8.16%ID/g at 1 h to 0.02±0.00%ID/g at 72 h post-injection (p.i.), while reaching its maximum accumulation in tumors at 48 h p.i., with half-life in blood of 10.2 h. The results were supported by that of 177 Lu-liposomes. Scintigraphic imaging with 111 In-liposomes showed unambiguous tumor images at 48 h p.i. Dose estimation showed that the absorbed dose in tumor from 177 Lu-liposomes was 5.74x10 -5 Gy/MBq. Conclusions: This study provides an in vivo characterization and dosimetric evaluation for the use of liposome systems as carriers in targeted radionuclide therapy. The results suggest that adequate tumor targeting as well as dose delivered to tumors could be achieved by the use of radionuclide targeted liposomes

  8. Somatostatin-based Radiopeptide Therapy with [177Lu-DOTA]-TOC versus [90Y-DOTA]-TOC in Neuroendocrine Tumors

    OpenAIRE

    Romer A Seiler D Marincek N Brunner P Koller MT Ng QK Maecke HR Muller-Brand J Rochlitz C B

    2014-01-01

    PURPOSE: Somatostatin based radiopeptide treatment is generally performed using the ß emitting radionuclides (90)Y or (177)Lu. The present study aimed at comparing benefits and harms of both therapeutic approaches. METHODS: In a comparative cohort study patients with advanced neuroendocrine tumours underwent repeated cycles of [(90)Y DOTA] TOC or [(177)Lu DOTA] TOC until progression of disease or permanent adverse events. Multivariable Cox regression and competing risks regression were emplo...

  9. First-principles study of electronic and elastic properties of LuAl{sub 3}

    Energy Technology Data Exchange (ETDEWEB)

    Shukla, Pushplata, E-mail: pujashukla50@gmail.com; Shrivastava, Deepika; Sanyal, Sankar P. [Department of Physics, Barkatullah university, Bhopal 462026 (India)

    2016-05-06

    A systematic theoretical study of electronic structure of rare earth intermetallic LuAl{sub 3} has been carried out using full potential linearized augmented plane wave (FP-LAPW) method based on density functional theory (DFT) within the generalized gradient approximation(GGA) for exchange and correlation potential. The ground state properties such as lattice constant (a{sub o}), bulk modulus (B) and pressure derivative of bulk modulus (B′) were evaluated. LuAl{sub 3} has the cubic AuCu{sub 3} type crystal structure. The electronic properties of this compound have been analyzed quantatively from band structure and DOS. It is clear from band structure that this compound is metallic in nature. The calculated elastic constants infer that this compound is mechanically stable.

  10. Spectral properties and laser performance of Tm, Ho: LuLF4 crystal

    Science.gov (United States)

    Peng, Haiyan; Zhang, Kun; Zhang, Lianhan; Hang, Yin; Xu, Jianqiu; Tang, Yulong; Cheng, Yan; Xiong, Jing

    2008-12-01

    LuLiF4 single crystals co-doped with thulium (5%) and holmium (0.5%), which had large size, intact shape and high optical quality, were successfully grown by the medium frequency induction heating Czochralski Technique. The absorption spectrum of the crystals showed that the main absorption peak located at 686 nm and 792nm. At room temperature, LuLiF4 single crystals co-doped with thulium (5%) and holmium (0.5%) were end-pumped by a fiber-coupled laser diode system with pumping wavelength of 795 nm. We achieved power of 50 mw continuous laser output at 2.05 μm wavelength.

  11. Analysis of heat capacity and Mössbauer data for LuZnSn2 compound

    Directory of Open Access Journals (Sweden)

    Łątka Kazimierz

    2015-03-01

    Full Text Available New analysis of heat capacity data is presented for LuZnSn2 compound that takes into account anharmonic effects together with the existence of Einstein modes. 119mSn Mössbauer spectroscopy was used to monitor the hyperfine parameters at the two crystallographically inequivalent Sn sites in the studied compound. The problem of non-unique mathematical resonance spectrum description and the problem how to choose physically meaningful set of hyperfine parameters will be thoroughly discussed. Measured quadrupole interaction constants by 119mSn Mössbauer spectroscopy give estimations for Vzz component of electric field gradient tensor at both Sn sites in LuZnSn2.

  12. High pressure Raman scattering study on the phase stability of LuVO4

    International Nuclear Information System (INIS)

    Rao, Rekha; Garg, Alka B.; Sakuntala, T.; Achary, S.N.; Tyagi, A.K.

    2009-01-01

    High pressure Raman spectroscopic investigations have been carried out on rare earth orthovanadate LuVO 4 upto 26 GPa. Changes in the Raman spectrum around 8 GPa across the reported zircon to scheelite transition are investigated in detail and compared with those observed in other vanadates. Co-existence of the zircon and scheelite phases is observed over a pressure range of about 8-13 GPa. The zircon to scheelite transition is irreversible upon pressure release. Subtle changes are observed in the Raman spectrum above 16 GPa which could be related to scheelite ↔ fergusonite transition. Pressure dependencies of the Raman active modes in the zircon and the scheelite phases are reported. - Graphical abstract: Study of scheelite-fergusonite transition in RVO 4 by Raman spectroscopy is rare. Here we report Raman spectroscopic investigations of LuVO 4 at high pressure to obtain insight into nature of post-scheelite phases.

  13. SuperLU{_}DIST: A scalable distributed-memory sparse direct solver for unsymmetric linear systems

    Energy Technology Data Exchange (ETDEWEB)

    Li, Xiaoye S.; Demmel, James W.

    2002-03-27

    In this paper, we present the main algorithmic features in the software package SuperLU{_}DIST, a distributed-memory sparse direct solver for large sets of linear equations. We give in detail our parallelization strategies, with focus on scalability issues, and demonstrate the parallel performance and scalability on current machines. The solver is based on sparse Gaussian elimination, with an innovative static pivoting strategy proposed earlier by the authors. The main advantage of static pivoting over classical partial pivoting is that it permits a priori determination of data structures and communication pattern for sparse Gaussian elimination, which makes it more scalable on distributed memory machines. Based on this a priori knowledge, we designed highly parallel and scalable algorithms for both LU decomposition and triangular solve and we show that they are suitable for large-scale distributed memory machines.

  14. Study On Preparation Of 177Lu-EDTMP For Metastatic Bone Pain Palliation Treatment

    International Nuclear Information System (INIS)

    Nguyen Thanh Binh; Dang Ho Hong Quang; Duong Van Dong; Chu Van Khoa; Nguyen Thi Hien

    2011-01-01

    Ethylene diamine tetramethylene phosphonate (EDTMP) is one of the most widely used ligands which forms stable complexes with various radionuclides and all the complexes showed high bone uptake in biodistribution studies. EDTMP has a high affinity to skeleton and osteoblastic bone metastases and many EDTMP chelates posses a considerably high stability.This stimulated application of the ligand as the in-vivo carrier of various radionuclides, intended for both therapy and diagnosis of osteoblastic lesions.The present study intends to formulate EDTMP kits, label them with 177 Lu, quality control and in-vitro stability studies. This paper presents some research results on the optimal conditions for labeling EDTMP kit with Lu-177 of low specific activity that was produced on the IVV-9 reactor at the Nuclear Research Institute. (author)

  15. The low-temperature heat capacities of Tb, Lu and Y

    International Nuclear Information System (INIS)

    Wells, P.; Lanchester, P.C.; Jones, D.W.; Jordan, R.G.

    1976-01-01

    The heat capacities of Tb, Lu and Y, refined by solid state electro-transport processing have been measured between 1.5 and 16 K. Below 4 K the results were fitted to the expression C = γT + AT 3 where for Tb the nuclear and magnetic contributions were first calculated and subtracted from the total heat capacity. The resultant values of γ(mJ mol -1 K -2 ) and limiting Debye temperatures thetasub(D) (T → 0) were as follows. Tb: γ = 4.4 +- 0.1, thetasub(D) = 178 +- 2 K; Lu: γ = 6.8 +- 0.1, thetasub(D) 205 +- 3 K; Y: γ = 8.2 +- 0.1, thetasub(D) = 248 +- 3 K. The Debye temperature was found in all instances to decrease by about 10% between 4 and 16 K. (author)

  16. Metodika stanovení velikosti detekovaného signálu v EREM

    OpenAIRE

    Potoma, Jaroslav

    2010-01-01

    Předkládaná práce se zabývá problematikou environmentální rastrovací elektronové mikroskopie (EREM) a detekcí signálních elektronů pomocí ionizačního detektoru.Hlavní náplní této práce je porovnání osciloskopické metody stanovení velikosti signálu s metodou vyhodnocování velikosti signálu z úrovně šedi ze snímků standartních vzorků. Vyhodnocení výhod a nevýhod obou metod. This work deals with problematics of enviromental scanning electron microscopy and detection of signal electrons by ion...

  17. Single crystalline LuAG fibers for homogeneous dual-readout calorimeters

    International Nuclear Information System (INIS)

    Pauwels, K; Gundacker, S; Lecoq, P; Lucchini, M; Auffray, E; Dujardin, C; Lebbou, K; Moretti, F; Xu, X; Petrosyan, A G

    2013-01-01

    For the next generation of calorimeters, designed to improve the energy resolution of hadrons and jets measurements, there is a need for highly granular detectors requiring peculiar geometries. Heavy inorganic scintillators allow compact homogeneous calorimeter designs with excellent energy resolution and dual-readout abilities. These scintillators are however not usually suited for geometries with a high aspect ratio because of the important losses observed during the light propagation. Elongated single crystals (fibers) of Lutetium Aluminium garnet (LuAG, Lu 3 Al 5 O 12 ) were successfully grown with the micropulling-down technique. We present here the results obtained with the recent fiber production and we discuss how the light propagation could be enhanced to reach attenuation lengths in the fibers better than 0.5 m

  18. Crystal fields of dilute Tb, Dy, Ho, or Er in Lu obtained by magnetization measurements

    International Nuclear Information System (INIS)

    Touborg, P.; Hog, J.

    1975-01-01

    Magnetization measurements are reported on single crystals of dilute Tb, Dy, Ho, or Er in Lu. These measurements were performed in the temperature range 1.5--100 K and field range 0--6 T and include measurements of initial susceptibility, isothermal and isofield magnetization, and basal-plane anisotropy. The results show features similar to the corresponding Y-R alloys, where R is a rare earth. Crystal-field and molecular-field parameters could be unabiguously deduced from the experimental data. The effects of crystal-field level broadening were investigated and demonstrated for Ho. Comparison of the Y-R and Lu-R results makes possible an estimate of the crystal-field parameters in the pure-rare-earth metals

  19. Tl response of KMgF3: Lu + PTFE at ultraviolet radiation

    International Nuclear Information System (INIS)

    Gonzalez, P.R.; Alarcon, N.G.; Furetta, C.; Azorin, J.

    2003-01-01

    Ionizing radiation has different types of interaction with a crystalline solid. However, only few effects are interesting to optimize some thermoluminescent (Tl) properties of certain Tl materials. This paper presents results obtained by irradiating KMgF 3 : Lu + Ptfe Tl dosimeters with ultraviolet (UV) radiation previously exposed to gamma radiation. These results showed that those dosimeters not exposed previously to gamma radiation did not presented any Tl signal. Meanwhile, those previously submitted to gamma irradiation showed that their sensitivity was increased as the gamma dose increased. The glow curve of sensitized KMgF 3 : Lu + Ptfe exposed to UV radiation, presented the dosimetric pea at 212 C. This makes this material to be promissory for measuring UV radiation. (Author)

  20. An implict LU scheme for the Euler equations applied to arbitrary cascades. [new method of factoring

    Science.gov (United States)

    Buratynski, E. K.; Caughey, D. A.

    1984-01-01

    An implicit scheme for solving the Euler equations is derived and demonstrated. The alternating-direction implicit (ADI) technique is modified, using two implicit-operator factors corresponding to lower-block-diagonal (L) or upper-block-diagonal (U) algebraic systems which can be easily inverted. The resulting LU scheme is implemented in finite-volume mode and applied to 2D subsonic and transonic cascade flows with differing degrees of geometric complexity. The results are presented graphically and found to be in good agreement with those of other numerical and analytical approaches. The LU method is also 2.0-3.4 times faster than ADI, suggesting its value in calculating 3D problems.

  1. Adaptive control of servo system based on LuGre model

    Science.gov (United States)

    Jin, Wang; Niancong, Liu; Jianlong, Chen; Weitao, Geng

    2018-03-01

    This paper established a mechanical model of feed system based on LuGre model. In order to solve the influence of nonlinear factors on the system running stability, a nonlinear single observer is designed to estimate the parameter z in the LuGre model and an adaptive friction compensation controller is designed. Simulink simulation results show that the control method can effectively suppress the adverse effects of friction and external disturbances. The simulation show that the adaptive parameter kz is between 0.11-0.13, and the value of gamma1 is between 1.9-2.1. Position tracking error reaches level 10-3 and is stabilized near 0 values within 0.3 seconds, the compensation method has better tracking accuracy and robustness.

  2. Quantum oscillation measurements of β-LuAlB{sub 4}

    Energy Technology Data Exchange (ETDEWEB)

    Reiss, Pascal; Baglo, Jordan; Chen, Xiaoye; Tan, HongEn; Sutherland, Michael; Grosche, F. Malte [Cavendish Laboratory, University of Cambridge, Cambridge (United Kingdom); Friedemann, Sven [HH Wills Laboratory, University of Bristol, Bristol (United Kingdom); Goh, Swee K. [Chinese University of Hong Kong, Shatin, N.T. (China); Kuga, Kentaro; Nakatsuji, Satoru [Institute for Solid State Physics, University of Tokyo, Kashiwa (Japan); Harima, Hisatomo [Department of Physics, Graduate School of Science, Kobe University, Kobe (Japan)

    2016-07-01

    The Yb-based heavy fermion superconductor β-YbAlB{sub 4} displays a quantum critical point without tuning by applied pressure, magnetic field, or doping, which has been attributed to an unusual renormalised band structure. Quantum oscillation measurements of the Fermi surface in β-YbAlB{sub 4} have so far proved inconclusive, motivating us to undertake a detailed study of the isostructural reference compound β-LuAlB{sub 4}, which in contrast to the Yb compound is characterised by a filled 4f shell. We present comprehensive results from rotation and mass studies in β-LuAlB{sub 4}, which broadly agree with band structure calculations and display moderate mass enhancements contrasting with the much larger enhancements seen in β-YbAlB{sub 4} - further emphasising the important contribution of f electrons to the itinerant electron physics of β-YbAlB{sub 4}.

  3. Electric quadrupole moments and strong interaction effects in pionic atoms of 165Ho, 175Lu, 176Lu, 179Hf and 181Ta

    International Nuclear Information System (INIS)

    Olaniyi, B.; Shor, A.; Cheng, S.C.; Dugan, G.; Wu, C.S.

    1981-05-01

    The effective quadrupole moments Q sub(eff) of the nuclei of 165 Ho, 175 Lu, 176 Lu, 179 Hf and 181 Ta were accurately measured by detecting the pionic atom 5g-4f x-rays of the elements. The spectroscopic quadrupole moments, Q sub(spec), were obtained by correcting Q sub(eff) for nuclear finite size effect, distortion of the pion wave function by the pion-nucleus strong interaction, and contribution to the energy level splittings by the strong interaction. The intrinsic quadrupole moments, Q 0 , were obtained by projecting Q sub(spec) into the frame of reference fixed on the nucleus. The shift, epsilon 0 , and broadening, GAMMA 0 , of the 4f energy level due to the strong interactions between the pion and the nucleons for all the elements were also measured. Theoretical values of epsilon 0 and GAMMA 0 were calculated and compared to the experimental values. The measured values of Q 0 were compared with the existing results in muonic and pionic atoms. The measured values of epsilon 0 and GAMMA 0 were also compared with existing values. (auth)

  4. PROVERBS AND SOME OF THE USAGES IN THE EPIC OF KÖROĞLU / ATASÖZLERI VE KÖROĞLU DESTANI’NDA BAZI KULLANIMLARI

    Directory of Open Access Journals (Sweden)

    Mehmet Emin BARS (M.A.H.

    2008-09-01

    Full Text Available The epic of Köroğlu is an epical work that left deep influencesall over the Turkish world and over the nations lived together withTurks for long centuries. Even today when taken into consideration ofthe wideness of its narrated and listened geopraphical area, itsimportance from the view of maintaining the cultural integritybetween Turks will be understood much better. Đt is difficult to comeacross such a work like the epic of Köroğlu which maintains itsimportance with a wide performance area, in the lives of other nations.As for proverbs they are the expressions which tell a nation’s standardof judgement. These expressions containing the acquirement of thelife experiences for centuries inform that nation’s thought, yearning,criticism, observation and ideas. They advise people the principles andthe rules aiming to teach the good, the beautiful and the truth. Đn ourwriting the proverbs which take place in Turkoman variant of Köroğluwill be discussed.

  5. Plastic pollutants in water environment

    Directory of Open Access Journals (Sweden)

    Mrowiec Bożena

    2017-12-01

    Full Text Available Nowadays, wide applications of plastics result in plastic waste being present in the water environment in a wide variety of sizes. Plastic wastes are in water mainly as microplastics (the size range of 1 nm to < 5 mm. Microplastics have been recognized as an emerging threat, as well as ecotoxicological and ecological risk for water ecosystems. In this review are presented some of the physicochemical properties of plastic materials that determine their toxic effect on the aquatic environment. Wastewater treatment plants (WWTPs are mentioned as one of main sources of microplastics introduced into fresh water, and rivers are the pathways for the transportation of the pollutants to seas and oceans. But, effluents from tertiary wastewater treatment facilities can contain only minimally microplastic loads. The issue of discharge reduction of plastic pollutants into water environment needs activities in the scope of efficient wastewater treatment, waste disposal, recycling of plastic materials, education and public involvement.

  6. Development of 177Lu-DOTA-anti-CD20 for radioimmunotherapy

    International Nuclear Information System (INIS)

    Hassan Yousefnia; Amir Reza Jalilian; Ali Bahrami-Samani; Simindokht Shirvani-Arani; Mohammad Ghannadi-Maragheh; Azim Arbabi; Edalat Radfar

    2011-01-01

    Rituximab was successively labeled with 177 Lu-lutetium chloride. 177 Lu chloride was obtained by thermal neutron flux (4 x 1013 n cm -2 s -1 ) of natural Lu 2 O 3 sample with a specific activity of 2.6-3 GBq/mg. The macrocyclic bifunctional chelating agent, N-succinimidyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA-NHS) was prepared at 25 deg C using DOTA, N-hydroxy succinimide (NHS) in CH 2 Cl 2 . DOTA-rituximab was obtained by the addition of 1 mL of a rituximab pharmaceutical solution (5 mg/mL, in phosphate buffer, pH 7.8) to a glass tube pre-coated with DOTA-NHS (0.01-0.1 mg) at 25 deg C with continuous mild stirring for 15 h. Radiolabeling was performed at 37 deg C in 24 h. Radio-thin layer chromatography showed an overall radiochemical purity of >98% at optimized conditions (specific activity = 444 MBq/mg, labeling efficacy; 82%). The final isotonic 177 Lu-DOTA-rituximab complex was checked by gel electrophoresis for structure integrity control. Radio-TLC was performed to ensure that only one species was present after filtration through a 0.22 μm filter. Preliminary biodistribution studies in normal rats were carried out to determine complex distribution of the radioimmunoconjugate up to 168 h. The biodistribution data were in accordance with other antiCD20 radioimmunoconjugates already reported. (author)

  7. Achieving numerical accuracy and high performance using recursive tile LU factorization with partial pivoting

    KAUST Repository

    Dongarra, Jack

    2013-09-18

    The LU factorization is an important numerical algorithm for solving systems of linear equations in science and engineering and is a characteristic of many dense linear algebra computations. For example, it has become the de facto numerical algorithm implemented within the LINPACK benchmark to rank the most powerful supercomputers in the world, collected by the TOP500 website. Multicore processors continue to present challenges to the development of fast and robust numerical software due to the increasing levels of hardware parallelism and widening gap between core and memory speeds. In this context, the difficulty in developing new algorithms for the scientific community resides in the combination of two goals: achieving high performance while maintaining the accuracy of the numerical algorithm. This paper proposes a new approach for computing the LU factorization in parallel on multicore architectures, which not only improves the overall performance but also sustains the numerical quality of the standard LU factorization algorithm with partial pivoting. While the update of the trailing submatrix is computationally intensive and highly parallel, the inherently problematic portion of the LU factorization is the panel factorization due to its memory-bound characteristic as well as the atomicity of selecting the appropriate pivots. Our approach uses a parallel fine-grained recursive formulation of the panel factorization step and implements the update of the trailing submatrix with the tile algorithm. Based on conflict-free partitioning of the data and lockless synchronization mechanisms, our implementation lets the overall computation flow naturally without contention. The dynamic runtime system called QUARK is then able to schedule tasks with heterogeneous granularities and to transparently introduce algorithmic lookahead. The performance results of our implementation are competitive compared to the currently available software packages and libraries. For example

  8. Luís de Camões - O Lírico

    Directory of Open Access Journals (Sweden)

    Sigismundo Spina

    1953-03-01

    Full Text Available CIDADE (Hernani. - Luís de Camões - O Lírico . Livraria Bertrand, Lisboa, 1952. 354 pp. (Primeiro Parágrafo do Artigo Os estudos da obra lírica de Camões levados a efeito pela erudição de Hernani Cidade datam de quase 20 anos, quando em 1936, na "Revista da Faculdade de Lisboa", escreveu "LUIS DE CAMÕES" - o Lírico.

  9. A study on the regional geological setting of uranium metallogenesis in Lu-Zong region

    International Nuclear Information System (INIS)

    Chen Yifeng; Ma Changming; Fan Huanxin

    1996-01-01

    This paper presents a new understanding of features of main ore-bearing horizons and magmatic rocks, evolution regularities, regional tectonic characteristics and the compositions and formation of the Yangtze tectonic belt in Lu-Zong region. Favourable horizons, magmatic series of Yangtze-type crust-mantle mixed melting magmatic rocks, activities of regional gigantic deep-seated faults and their subsidiary structures provided good regional geological setting for the formation of uranium and polymetallic mineral resources in this region

  10. Long-term toxicity of [177Lu-DOTA0,Tyr3]octreotate in rats

    International Nuclear Information System (INIS)

    Rolleman, Edgar J.; Krenning, Eric P.; Bernard, Bert F.; Visser, Monique de; Bijster, Magda; Jong, Marion de; Visser, Theo J.; Vermeij, Marcel; Lindemans, Jan

    2007-01-01

    Studies on peptide receptor radionuclide therapy (PRRT) using radiolabelled somatostatin analogues have shown promising results with regard to tumour control. The efficacy of PRRT is limited by uptake and retention in the proximal tubules of the kidney, which might lead to radiation nephropathy. We investigated the long-term renal toxicity after different doses of [ 177 Lu-DOTA 0 ,Tyr 3 ]octreotate and the effects of dose fractionation and lysine co-injection in two tumour-bearing rat models. Significant renal toxicity was detected beyond 100 days after start of treatment as shown by elevated serum creatinine and proteinuria. Microscopically, tubules were strongly dilated with flat epithelium, containing protein cylinders. Creatinine levels rose significantly after 555 MBq [ 177 Lu-DOTA 0 ,Tyr 3 ]octreotate, but were significantly lower after 278 MBq (single injection) or two weekly doses of 278 MBq. Renal damage scores were maximal after 555 MBq and significantly lower in the 278 and 2 x 278 MBq groups. Three doses of 185 MBq [ 177 Lu-DOTA 0 ,Tyr 3 ]octreotate with intervals of a day, a week or a month significantly influenced serum creatinine (469±18, 134±70 and 65±15 μmol/l, respectively; p 177 Lu-DOTA 0 ,Tyr 3 ]octreotate resulted in severe renal damage in rats as indicated by proteinuria, elevated serum creatinine and histological damage. This damage was dose dependent and became overt between 100 and 200 days after treatment. Dose fractionation had significant beneficial effects on kidney function. Also, lysine co-injection successfully prevented functional damage. (orig.)

  11. Transcriptional response of kidney tissue after 177Lu-octreotate administration in mice

    International Nuclear Information System (INIS)

    Schüler, Emil; Rudqvist, Nils; Parris, Toshima Z.; Langen, Britta; Helou, Khalil; Forssell-Aronsson, Eva

    2014-01-01

    Introduction: The kidneys are one of the main dose limiting organs in 177 Lu-octreotate therapy of neuroendocrine tumors. Therefore, biomarkers for radiation damage would be of great importance in this type of therapy. The purpose of this study was to investigate the absorbed dose dependency on early transcriptional changes in the kidneys from 177 Lu-octreotate exposure. Methods: Female Balb/c nude mice were i.v. injected with 1.3, 3.6, 14, 45 or 140 MBq 177 Lu-octreotate. The animals were killed 24 h after injection followed by excision of the kidneys. The absorbed dose to the kidneys ranged between 0.13 and 13 Gy. Total RNA was extracted from separated renal tissue samples, and applied to Illumina MouseRef-8 Whole-Genome Expression Beadchips to identify regulated transcripts after irradiation. Nexus Expression 2.0 and Gene Ontology terms were used for data processing and to determine affected biological processes. Results: Distinct transcriptional responses were observed following 177 Lu-octreotate administration. A higher number of differentially expressed transcripts were observed in the kidney medulla (480) compared to cortex (281). In addition, 39 transcripts were regulated at all absorbed dose levels in the medulla, compared to 32 in the cortex. Three biological processes in the cortex and five in the medulla were also shared by all absorbed dose levels. Strong association to metabolism was found among the affected processes in both tissues. Furthermore, an association with cellular and developmental processes was prominent in kidney medulla, while transport and immune response were prominent in kidney cortex. Conclusion: Specific biological and dose-dependent responses were observed in both tissues. The number of affected transcripts and biological processes revealed distinct response differences between the absorbed doses delivered to the tissues

  12. First principle calculation of structure and lattice dynamics of Lu2Si2O7

    Directory of Open Access Journals (Sweden)

    Nazipov D.V.

    2017-01-01

    Full Text Available Ab initio calculations of crystal structure and Raman spectra has been performed for single crystal of lutetium pyrosilicate Lu2Si2O7. The types of fundamental vibrations, their frequencies and intensities in the Raman spectrum has been obtained for two polarizations. Calculations were made in the framework of density functional theory (DFT with hybrid functionals. The isotopic substitution was calculated for all inequivalent ions in cell. The results in a good agreement with experimental data.

  13. Anisotropy of magnetoelastic phenomena in Lu.sub.2./sub.Fe.sub.17./sub. intermetallics

    Czech Academy of Sciences Publication Activity Database

    Kamarád, Jiří; Skorokhod, Yuriy; Machátová, Zuzana; Arnold, Zdeněk; Andreev, Alexander V.

    272-276, - (2004), s. 2098-2099 ISSN 0304-8853 R&D Projects: GA AV ČR IAA1010315; GA ČR GA202/02/0739 Institutional research plan: CEZ:AV0Z1010914 Keywords : magnetoelastic effects * anisotropy * high pressure * Lu2 Fe 17 Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 1.031, year: 2004

  14. Achieving numerical accuracy and high performance using recursive tile LU factorization with partial pivoting

    KAUST Repository

    Dongarra, Jack; Faverge, Mathieu; Ltaief, Hatem; Luszczek, Piotr R.

    2013-01-01

    The LU factorization is an important numerical algorithm for solving systems of linear equations in science and engineering and is a characteristic of many dense linear algebra computations. For example, it has become the de facto numerical algorithm implemented within the LINPACK benchmark to rank the most powerful supercomputers in the world, collected by the TOP500 website. Multicore processors continue to present challenges to the development of fast and robust numerical software due to the increasing levels of hardware parallelism and widening gap between core and memory speeds. In this context, the difficulty in developing new algorithms for the scientific community resides in the combination of two goals: achieving high performance while maintaining the accuracy of the numerical algorithm. This paper proposes a new approach for computing the LU factorization in parallel on multicore architectures, which not only improves the overall performance but also sustains the numerical quality of the standard LU factorization algorithm with partial pivoting. While the update of the trailing submatrix is computationally intensive and highly parallel, the inherently problematic portion of the LU factorization is the panel factorization due to its memory-bound characteristic as well as the atomicity of selecting the appropriate pivots. Our approach uses a parallel fine-grained recursive formulation of the panel factorization step and implements the update of the trailing submatrix with the tile algorithm. Based on conflict-free partitioning of the data and lockless synchronization mechanisms, our implementation lets the overall computation flow naturally without contention. The dynamic runtime system called QUARK is then able to schedule tasks with heterogeneous granularities and to transparently introduce algorithmic lookahead. The performance results of our implementation are competitive compared to the currently available software packages and libraries. For example

  15. Magnetic ground state of the multiferroic hexagonal LuFe O3

    Science.gov (United States)

    Suresh, Pittala; Vijaya Laxmi, K.; Bera, A. K.; Yusuf, S. M.; Chittari, Bheema Lingam; Jung, Jeil; Anil Kumar, P. S.

    2018-05-01

    The structural, electric, and magnetic properties of bulk hexagonal LuFe O3 are investigated. Single phase hexagonal LuFe O3 has been successfully stabilized in the bulk form without any doping by sol-gel method. The hexagonal crystal structure with P 63c m space group has been confirmed by x-ray-diffraction, neutron-diffraction, and Raman spectroscopy study at room temperature. Neutron diffraction confirms the hexagonal phase of LuFe O3 persists down to 6 K. Further, the x-ray photoelectron spectroscopy established the 3+ oxidation state of Fe ions. The temperature-dependent magnetic dc susceptibility, specific heat, and neutron-diffraction studies confirm an antiferromagnetic ordering below the Néel temperature (TN)˜130 K . Analysis of magnetic neutron-diffraction patterns reveals an in-plane (a b -plane) 120∘ antiferromagnetic structure, characterized by a propagation vector k =(0 0 0 ) with an ordered moment of 2.84 μB/F e3 + at 6 K. The 120∘ antifferomagnetic ordering is further confirmed by spin-orbit coupling density functional theory calculations. The on-site coulomb interaction (U ) and Hund's parameter (JH) on Fe atoms reproduced the neutron-diffraction Γ1 spin pattern among the Fe atoms. P -E loop measurements at room temperature confirm an intrinsic ferroelectricity of the sample with remnant polarization Pr˜0.18 μ C /c m2 . A clear anomaly in the dielectric data is observed at ˜TN revealing the presence of magnetoelectric coupling. A change in the lattice constants at TN has also been found, indicating the presence of a strong magnetoelastic coupling. Thus a coupling between lattice, electric, and magnetic degrees of freedom is established in bulk hexagonal LuFe O3 .

  16. Development of a lyophilized formulation for preparing the radiopharmaceutical 177Lu-DOTA-Anti-CD20

    International Nuclear Information System (INIS)

    Serrano E, L. A.

    2015-01-01

    The radiolabeled proteins are molecules of interest in nuclear medicine for their diagnostic and therapeutic application in cancer. Antibodies, such as chimeric monoclonal antibody Anti-CD20 rituximab, have established themselves as suitable vectors of radionuclides (e.g. 177 Lu) , introducing high affinity by the surface antigens over- expressed and widely distributed in cells involved in certain diseases. The aim of this work was to design, optimize and document the production process of radiopharmaceutical 177 Lu-DOTA-Anti-CD20 for sanitary registration request to the Comision Federal para la Proteccion contra Riesgos Sanitarios (COFEPRIS). First, a raw material analysis using the Ft-Mir technique and gamma spectrometry was performed. Then, was carried out the development of the lyophilized formulation for the preparation of 177 Lu-DOTA-Anti-CD20, in which an ANOVA was performed where the dependent variable was the radiochemical purity. The optimal pharmaceutical formulation was: 5 mg DOTA-CD20 and 80 mg Mannitol to be reconstituted with 1 m L of acetate buffer 0.25 M, ph 7, with an incubation time of 15 min at 37 degrees Celsius in a dry bath. Once completed the development of the lyophilized formulation, we proceeded to the optimization of the production process, development and validation of the analytical method. Three batches were prepared under protocols of Good Manufacturing Practice, which met pre-established specifications as sterile and endotoxin-free of bacterial formulations, with greater that 95% of radiochemical purity. Currently, is conducting the study of shelf stability. Upon completion of the stability studies, the legal record of 177 Lu-DOTA-Anti-CD20 will be integrated with documented evidence of the quality and stability of the formulation of this radiopharmaceutical. (Author)

  17. Electronic structures and superconductivity in LuTE2Si2 phases (TE = d-electron transition metal)

    Science.gov (United States)

    Samsel-Czekała, M.; Chajewski, G.; Wiśniewski, P.; Romanova, T.; Hackemer, A.; Gorzelniak, R.; Pikul, A. P.; Kaczorowski, D.

    2018-05-01

    In the course of our search for unconventional superconductors amidst the 1:2:2 phases, we have re-investigated the LuTE2Si2 compounds with TE = Fe, Co, Ni, Ru, Pd and Pt. In this paper, we present the results of our fully relativistic ab initio calculations of the band structures, performed using the full-potential local-orbital code. The theoretical data are supplemented by the results of low-temperature electrical transport and specific heat measurements performed down to 0.35 K. All the materials studied but LuPt2Si2 crystallize with the body-centered tetragonal ThCr2Si2-type structure (space group I4/mmm). Their Fermi surfaces exhibit a three-dimensional multi-band character. In turn, the Pt-bearing compound adopts the primitive tetragonal CaBe2Ge2-type structure (space group P4/nmm), and its Fermi surface consists of predominantly quasi-two-dimensional sheets. Bulk superconductivity was found only in LuPd2Si2 and LuPt2Si2 (independent of the structure type and dimensionality of the Fermi surface). The key superconducting characteristics indicate a fully-gapped BCS type character. Though the electronic structure of LuFe2Si2 closely resembles that of the unconventional superconductor YFe2Ge2, this Lu-based silicide exhibits neither superconductivity nor spin fluctuations at least down to 0.35 K.

  18. Nd-doped Lu3Al5O12 single-crystal scintillator for X-ray imaging

    International Nuclear Information System (INIS)

    Sugiyama, Makoto; Fujimoto, Yutaka; Yanagida, Takayuki; Totsuka, Daisuke; Chani, Valery; Yokota, Yuui; Yoshikawa, Akira

    2013-01-01

    The optical and scintillation properties of Nd-doped Lu 3 Al 5 O 12 (Nd:LuAG) crystals grown by the Czochralski (Cz) method were examined under X-ray excitation. Their applicability for X-ray imaging was also inspected. The radioluminescence spectrum induced by X-rays showed a broad host emission and sharp Nd 3+ 4f–4f emission peaks in the UV to visible wavelengths. The light output current of the Nd:LuAG was 85% of that of a standard CdWO 4 X-ray scintillator. The afterglow value measured 20 ms after X-ray irradiation was 1.5%. An X-ray radiographic image was successfully obtained using the Nd:LuAG scintillator coupled with the charge coupled device (CCD) photodetector. -- Highlights: ► The Nd:LuAG single crystal was produced to perform X-ray imaging test. ► The sample exhibited the 85% light output current of the standard CdWO 4 . ► The afterglow intensity of the sample was very high compared with the CdWO 4 . ► The X-ray radiographic image was obtained from the Nd:LuAG single crystal

  19. Plastic food packaging and health

    Directory of Open Access Journals (Sweden)

    Raika Durusoy

    2011-02-01

    Full Text Available Plastics have a wide usage in our daily lives. One of their uses is for food packaging and food containers. The aim of this review is to introduce different types of chemicals that can leach from food packaging plastics into foods and cause human exposure and to mention their effects on health. The types of plastics were reviewed under the 13 headings in Turkish Codex Alimentarius and plastics recycling symbols were provided to enable the recognition of the type of plastic when applicable. Chemicals used during the production and that can cause health risks are investigated under the heading of the relevant type of plastic. The most important chemicals from plastic food packaging that can cause toxicity are styrene, 1,3-butadiene, melamine, formaldehyde, acrylamide, di-2-ethylhexyl phthalate, di-2-ethylhexyl adipate, vinyl chloride and bisphenol A. These chemicals have endocrine disrupting, carcinogenic and/or development disrupting effects. These chemicals may leach into foods depending on the chemical properties of the plastic or food, temperature during packaging, processing and storage, exposure to UV and duration of storage. Contact with fatty/oily or acidic foods, heating of the food inside the container, or drinking hot drinks from plastic cups, use of old and scratched plastics and some detergents increase the risk of leaching. The use of plastic containers and packaging for food and beveradges should be avoided whenever possible and when necessary, less harmful types of plastic should be preferred. [TAF Prev Med Bull 2011; 10(1.000: 87-96

  20. Targeted radiotherapy with 177 Lu-DOTA-TATE in athymic mice with induced pancreatic malignant tumours

    International Nuclear Information System (INIS)

    Rodriguez C, J.; Murphy, C.A. de; Pedraza L, M.; Ferro F, G.; Murphy S, E.

    2006-01-01

    Malignant pancreas tumours induced in athymic mice are a good model for peptide receptor targeted radiotherapy. The objective of this research was to estimate pancreatic tumour absorbed radiation doses after administration of 177 Lu-DOTA-TATE in mice as a therapeutic radiopharmaceutical that could be used in humans. AR42J murine pancreas cancer cells expressing somatostatin receptors, were implanted in athymic mice (n=18) to obtain the 177 Lu-DOTA-TATE biokinetics and dosimetry. To estimate its therapeutic efficacy 87 MBq were injected in a tail vein of 3 mice and 19 days p.i. there were a partial relapse. There was an epithelial and sarcoma mixed tumour in the kidneys of mouse III. The absorbed dose to tumour, kidney and pancreas was 50.5 ± 7.2 Gy, 17.5 ± 2.5 Gy and 12.6 ± 2.3 Gy respectively. These studies justify further therapeutic and dosimetry estimations to ensure that 177 Lu-DOTA-TATE will act as expected in man considering its kidney radiotoxicity. (Author)

  1. An In-Depth Analysis of the Chung-Lu Model

    Energy Technology Data Exchange (ETDEWEB)

    Winlaw, M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); DeSterck, H. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Sanders, G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-10-28

    In the classic Erd}os R enyi random graph model [5] each edge is chosen with uniform probability and the degree distribution is binomial, limiting the number of graphs that can be modeled using the Erd}os R enyi framework [10]. The Chung-Lu model [1, 2, 3] is an extension of the Erd}os R enyi model that allows for more general degree distributions. The probability of each edge is no longer uniform and is a function of a user-supplied degree sequence, which by design is the expected degree sequence of the model. This property makes it an easy model to work with theoretically and since the Chung-Lu model is a special case of a random graph model with a given degree sequence, many of its properties are well known and have been studied extensively [2, 3, 13, 8, 9]. It is also an attractive null model for many real-world networks, particularly those with power-law degree distributions and it is sometimes used as a benchmark for comparison with other graph generators despite some of its limitations [12, 11]. We know for example, that the average clustering coe cient is too low relative to most real world networks. As well, measures of a nity are also too low relative to most real-world networks of interest. However, despite these limitations or perhaps because of them, the Chung-Lu model provides a basis for comparing new graph models.

  2. Angle-dependent magnetoresistance and quantum oscillations in high-mobility semimetal LuPtBi

    KAUST Repository

    Xu, Guizhou; Hou, Zhipeng; Wang, Yue; Zhang, Xiaoming; Zhang, Hongwei; Liu, Enke; Xi, X; Xu, Feng; Wu, Guangheng; Zhang, Xixiang; Wang, Wenhong

    2017-01-01

    The recent discovery of ultrahigh mobility and large positive magnetoresistance in topologically non-trivial Half-Heusler semimetal LuPtBi provides a unique playground for studying exotic physics and significant perspective for device applications. As an fcc-structured electron-hole-compensated semimetal, LuPtBi theoretically exhibits six symmetrically arranged anisotropic electron Fermi pockets and two nearly-spherical hole pockets, offering the opportunity to explore the physics of Fermi surface with a simple angle-related magnetotransport properties. In this work, through the angle-dependent transverse magnetoresistance measurements, in combination with high-field SdH quantum oscillations, we achieved to map out a Fermi surface with six anisotropic pockets in the high-temperature and low-field regime, and furthermore, identify a possible magnetic field driven Fermi surface change at lower temperatures. Reasons account for the Fermi surface change in LuPtBi are discussed in terms of the field-induced electron evacuation due to Landau quantization.

  3. Block recursive LU preconditioners for the thermally coupled incompressible inductionless MHD problem

    Science.gov (United States)

    Badia, Santiago; Martín, Alberto F.; Planas, Ramon

    2014-10-01

    The thermally coupled incompressible inductionless magnetohydrodynamics (MHD) problem models the flow of an electrically charged fluid under the influence of an external electromagnetic field with thermal coupling. This system of partial differential equations is strongly coupled and highly nonlinear for real cases of interest. Therefore, fully implicit time integration schemes are very desirable in order to capture the different physical scales of the problem at hand. However, solving the multiphysics linear systems of equations resulting from such algorithms is a very challenging task which requires efficient and scalable preconditioners. In this work, a new family of recursive block LU preconditioners is designed and tested for solving the thermally coupled inductionless MHD equations. These preconditioners are obtained after splitting the fully coupled matrix into one-physics problems for every variable (velocity, pressure, current density, electric potential and temperature) that can be optimally solved, e.g., using preconditioned domain decomposition algorithms. The main idea is to arrange the original matrix into an (arbitrary) 2 × 2 block matrix, and consider an LU preconditioner obtained by approximating the corresponding Schur complement. For every one of the diagonal blocks in the LU preconditioner, if it involves more than one type of unknowns, we proceed the same way in a recursive fashion. This approach is stated in an abstract way, and can be straightforwardly applied to other multiphysics problems. Further, we precisely explain a flexible and general software design for the code implementation of this type of preconditioners.

  4. A comparison of SuperLU solvers on the intel MIC architecture

    Science.gov (United States)

    Tuncel, Mehmet; Duran, Ahmet; Celebi, M. Serdar; Akaydin, Bora; Topkaya, Figen O.

    2016-10-01

    In many science and engineering applications, problems may result in solving a sparse linear system AX=B. For example, SuperLU_MCDT, a linear solver, was used for the large penta-diagonal matrices for 2D problems and hepta-diagonal matrices for 3D problems, coming from the incompressible blood flow simulation (see [1]). It is important to test the status and potential improvements of state-of-the-art solvers on new technologies. In this work, sequential, multithreaded and distributed versions of SuperLU solvers (see [2]) are examined on the Intel Xeon Phi coprocessors using offload programming model at the EURORA cluster of CINECA in Italy. We consider a portfolio of test matrices containing patterned matrices from UFMM ([3]) and randomly located matrices. This architecture can benefit from high parallelism and large vectors. We find that the sequential SuperLU benefited up to 45 % performance improvement from the offload programming depending on the sparse matrix type and the size of transferred and processed data.

  5. An ebCMOS camera system for marine bioluminescence observation: The LuSEApher prototype

    Energy Technology Data Exchange (ETDEWEB)

    Dominjon, A., E-mail: a.dominjon@ipnl.in2p3.fr [CNRS/IN2P3, Institut de Physique Nucleaire de Lyon, Villeurbanne F-69622 (France); Ageron, M. [CNRS/IN2P3, Centre de Physique des Particules de Marseille, Marseille, F-13288 (France); Barbier, R. [CNRS/IN2P3, Institut de Physique Nucleaire de Lyon, Villeurbanne F-69622 (France); Universite de Lyon, Universite Lyon 1, Lyon F-69003 (France); Billault, M.; Brunner, J. [CNRS/IN2P3, Centre de Physique des Particules de Marseille, Marseille, F-13288 (France); Cajgfinger, T. [CNRS/IN2P3, Institut de Physique Nucleaire de Lyon, Villeurbanne F-69622 (France); Universite de Lyon, Universite Lyon 1, Lyon F-69003 (France); Calabria, P. [CNRS/IN2P3, Institut de Physique Nucleaire de Lyon, Villeurbanne F-69622 (France); Chabanat, E. [CNRS/IN2P3, Institut de Physique Nucleaire de Lyon, Villeurbanne F-69622 (France); Universite de Lyon, Universite Lyon 1, Lyon F-69003 (France); Chaize, D.; Doan, Q.T.; Guerin, C.; Houles, J.; Vagneron, L. [CNRS/IN2P3, Institut de Physique Nucleaire de Lyon, Villeurbanne F-69622 (France)

    2012-12-11

    The ebCMOS camera, called LuSEApher, is a marine bioluminescence recorder device adapted to extreme low light level. This prototype is based on the skeleton of the LUSIPHER camera system originally developed for fluorescence imaging. It has been installed at 2500 m depth off the Mediterranean shore on the site of the ANTARES neutrino telescope. The LuSEApher camera is mounted on the Instrumented Interface Module connected to the ANTARES network for environmental science purposes (European Seas Observatory Network). The LuSEApher is a self-triggered photo detection system with photon counting ability. The presentation of the device is given and its performances such as the single photon reconstruction, noise performances and trigger strategy are presented. The first recorded movies of bioluminescence are analyzed. To our knowledge, those types of events have never been obtained with such a sensitivity and such a frame rate. We believe that this camera concept could open a new window on bioluminescence studies in the deep sea.

  6. The low temperature specific heat of Lu-Cu-Y metallic glasses

    International Nuclear Information System (INIS)

    Mohammed, K.A.; Lanchester, P.C.

    1987-01-01

    The specific heat of a series of amorphous metallic alloys of the form Lu x Cu 0.37 Y 0.36 (x=0, 0.1, 0.3 and 0.4) has been measured between 2 and 50 K, primarily in order to be able to determine the non-magnetic contributions to the specific heat in magnetic Re-Cu-Y amorphous alloys. The data at low temperature fit the simple form C p =γT+βT 3 from which values of γ and θ D (0) have been determined. Consideration is given to the error that arises if Y is used rather than Lu or La in forming non-magnetic rare earth intermetallics for purposes of determining the non-magnetic contributions to the specific heat of magnetic samples. A simple procedure is described that allows a useful improvement in accuracy in estimating non-magnetic contributions below 20 K if Y is used. The method may also be useful if only a restricted range of compositions using Lu is possible. (orig.)

  7. Low temperature specific heat of Lu-Cu-Y metallic glasses

    Energy Technology Data Exchange (ETDEWEB)

    Mohammed, K.A.; Lanchester, P.C.

    1987-02-01

    The specific heat of a series of amorphous metallic alloys of the form Lu/sub x/Cu/sub 0.37/Y/sub 0.36/ (x=0, 0.1, 0.3 and 0.4) has been measured between 2 and 50 K, primarily in order to be able to determine the non-magnetic contributions to the specific heat in magnetic Re-Cu-Y amorphous alloys. The data at low temperature fit the simple form C/sub p/=..gamma..T+..beta..T/sup 3/ from which values of ..gamma.. and theta/sub D/(0) have been determined. Consideration is given to the error that arises if Y is used rather than Lu or La in forming non-magnetic rare earth intermetallics for purposes of determining the non-magnetic contributions to the specific heat of magnetic samples. A simple procedure is described that allows a useful improvement in accuracy in estimating non-magnetic contributions below 20 K if Y is used. The method may also be useful if only a restricted range of compositions using Lu is possible.

  8. Targeted radiotherapy with 177 Lu-DOTA-TATE in athymic mice with induced pancreatic malignant tumours

    International Nuclear Information System (INIS)

    Murphy, M. A de; Pedraza L, M.; Rodriguez C, J.; Ferro F, G.; Murphy S, E.

    2006-01-01

    Malignant pancreas tumours induced in athymic mice are a good model for targeted radiotherapy. The objective of this research was to estimate pancreatic tumour absorbed radiation doses and to evaluate 177 Lu-DOTA-TATE as a therapeutic radiopharmaceutical that could be used in humans. AR42J murine pancreas cancer cells, which over-express somatostatin receptors, were injected in athymic mice and 20 days later the mean tumour size was 3.08 square cm (n=3). A mean of 86.3 MBq 177 Lu-DOTA-TATE, was injected in a tail vein and 19 days after therapy the size of the tumours was 0.81 square cm. There was a partial relapse and after 16 days, when sacrificed, the mean tumour size was 8.28 cubic cm. An epithelial and sarcoma mixed tumour in the kidney of one treated mouse was found. The tumour of the control mouse was 8.61 cubic cm when sacrificed 14 days after tumour induction. Radiotherapy estimates to the tumours was 35.9-39.7 Gy and the tumours might have been completely reduced with a second therapy dose. These preliminary studies justify further therapeutic and dosimetry estimations to ensure that Lu- 177 -DOTA-TATE will act as expected in man, considering kidney radiation. (Author)

  9. Comparative study of transparent ceramic and single crystal Ce doped LuAG scintillators

    International Nuclear Information System (INIS)

    Yanagida, Takayuki; Fujimoto, Yutaka; Yokota, Yuui; Kamada, Kei; Yanagida, Satoko; Yoshikawa, Akira; Yagi, Hideki; Yanagitani, Takagimi

    2011-01-01

    Transparent ceramic Ce 0.5% doped Lu 3 Al 5 O 12 (LuAG) scintillator grown by the sintering method and single crystalline Ce doped LuAG grown by the Czochralski method are prepared. They are cut to the physical dimensions 4 × 4 × 2 mm 3 . Their transmittance and radio luminescence spectra are evaluated. They are both transmissive in wavelength longer than 500 nm and intense Ce 3+ 5d–4f emission appears around 520 nm. When 137 Cs γ-ray is irradiated, 662 keV photo-absorption peaks are clearly observed in each sample. The transparent ceramic one shows higher light yield than that of the single crystalline one. The absolute light yield of the ceramic sample is turned out to be 14800 ± 1500 ph/MeV. The decay time constants are evaluated under pulse X-ray excitation. The main component of the decay time of ceramic and single crystalline one are determined as 37 and 46 ns, respectively.

  10. Angle-dependent magnetoresistance and quantum oscillations in high-mobility semimetal LuPtBi

    KAUST Repository

    Xu, Guizhou

    2017-03-14

    The recent discovery of ultrahigh mobility and large positive magnetoresistance in topologically non-trivial Half-Heusler semimetal LuPtBi provides a unique playground for studying exotic physics and significant perspective for device applications. As an fcc-structured electron-hole-compensated semimetal, LuPtBi theoretically exhibits six symmetrically arranged anisotropic electron Fermi pockets and two nearly-spherical hole pockets, offering the opportunity to explore the physics of Fermi surface with a simple angle-related magnetotransport properties. In this work, through the angle-dependent transverse magnetoresistance measurements, in combination with high-field SdH quantum oscillations, we achieved to map out a Fermi surface with six anisotropic pockets in the high-temperature and low-field regime, and furthermore, identify a possible magnetic field driven Fermi surface change at lower temperatures. Reasons account for the Fermi surface change in LuPtBi are discussed in terms of the field-induced electron evacuation due to Landau quantization.

  11. New polyvinylchloride plasticizers

    Directory of Open Access Journals (Sweden)

    MAZITOVA Aliya Karamovna

    2017-11-01

    Full Text Available One of the main large-capacity polymers of modern chemical industry is polyvinylchloride (PVC. Polyvinylchloride is characterized by many useful engineering properties – chemical firmness in different environments, good electric properties, etc. It explains immensely various use of materials on the basis of PVC in different engineering industries. It is cable, building, light industries, mechanical engineering and automotive industry where PVC is widely applied. One of the reasons why PVC production is dramatically growing is that there is no yet other polymer which could be subjected to such various modifying as it is done with PVC. However under normal temperature this polymer is fragile and isn't elastic that limits the field of its application. Rapid growth of production of polyvinylchloride is explained by its ability to modify properties, due to introduction of special additives when processing. Introduction of plasticizers – mostlly esters of organic and inorganic acids – into PVC allows significant changing properties of polymer. Plasticizers facilitate process of receiving polymeric composition, increase flexibility and elasticity of the final polymeric product due to internal modification of polymeric molecule.

  12. Americium behaviour in plastic vessels

    International Nuclear Information System (INIS)

    Legarda, F.; Herranz, M.; Idoeta, R.; Abelairas, A.

    2010-01-01

    The adsorption of 241 Am dissolved in water in different plastic storage vessels was determined. Three different plastics were investigated with natural and distilled waters and the retention of 241 Am by these plastics was studied. The same was done by varying vessel agitation time, vessel agitation speed, surface/volume ratio of water in the vessels and water pH. Adsorptions were measured to be between 0% and 70%. The adsorption of 241 Am is minimized with no water agitation, with PET or PVC plastics, and by water acidification.

  13. Americium behaviour in plastic vessels

    Energy Technology Data Exchange (ETDEWEB)

    Legarda, F.; Herranz, M. [Departamento de Ingenieria Nuclear y Mecanica de Fluidos, Escuela Tecnica Superior de Ingenieria de Bilbao, Universidad del Pais Vasco (UPV/EHU), Alameda de Urquijo s/n, 48013 Bilbao (Spain); Idoeta, R., E-mail: raquel.idoeta@ehu.e [Departamento de Ingenieria Nuclear y Mecanica de Fluidos, Escuela Tecnica Superior de Ingenieria de Bilbao, Universidad del Pais Vasco (UPV/EHU), Alameda de Urquijo s/n, 48013 Bilbao (Spain); Abelairas, A. [Departamento de Ingenieria Nuclear y Mecanica de Fluidos, Escuela Tecnica Superior de Ingenieria de Bilbao, Universidad del Pais Vasco (UPV/EHU), Alameda de Urquijo s/n, 48013 Bilbao (Spain)

    2010-07-15

    The adsorption of {sup 241}Am dissolved in water in different plastic storage vessels was determined. Three different plastics were investigated with natural and distilled waters and the retention of {sup 241}Am by these plastics was studied. The same was done by varying vessel agitation time, vessel agitation speed, surface/volume ratio of water in the vessels and water pH. Adsorptions were measured to be between 0% and 70%. The adsorption of {sup 241}Am is minimized with no water agitation, with PET or PVC plastics, and by water acidification.

  14. Americium behaviour in plastic vessels.

    Science.gov (United States)

    Legarda, F; Herranz, M; Idoeta, R; Abelairas, A

    2010-01-01

    The adsorption of (241)Am dissolved in water in different plastic storage vessels was determined. Three different plastics were investigated with natural and distilled waters and the retention of (241)Am by these plastics was studied. The same was done by varying vessel agitation time, vessel agitation speed, surface/volume ratio of water in the vessels and water pH. Adsorptions were measured to be between 0% and 70%. The adsorption of (241)Am is minimized with no water agitation, with PET or PVC plastics, and by water acidification. Copyright 2009 Elsevier Ltd. All rights reserved.

  15. 177Lu-labeled HPMA copolymers utilizing cathepsin B and S cleavable linkers: Synthesis, characterization and preliminary in vivo investigation in a pancreatic cancer model

    International Nuclear Information System (INIS)

    Ogbomo, Sunny M.; Shi, Wen; Wagh, Nilesh K.; Zhou, Zhengyuan; Brusnahan, Susan K.; Garrison, Jered C.

    2013-01-01

    Introduction: A major barrier to the advancement of therapeutic nanomedicines has been the non-target toxicity caused by the accumulation of the drug delivery systems in organs associated with the reticuloendothelial system, particularly the liver and spleen. Herein, we report the development of peptide based metabolically active linkers (MALs) that are enzymatically cleaved by cysteine cathepsin B and S, two proteases highly expressed in the liver and spleen. The overall goal of this approach is to utilize the MALs to lower the non-target retention and toxicity of radiolabeled drug delivery systems, thus resulting in higher diagnostic and radiotherapeutic efficacy. Methods: In this study three MALs (MAL0, MAL1 and MAL2) were investigated. MAL1 and MAL2 are composed of known substrates of cathepsin B and S, respectively, while MAL0 is a non-cleavable control. Both MAL1 and MAL2 were shown to undergo enzymatic cleavage with the appropriate cathepsin protease. Subsequent to conjugation to the HPMA copolymer and radiolabeling with 177 Lu, the peptide–polymer conjugates were renamed 177 Lu-metabolically active copolymers ( 177 Lu-MACs) with the corresponding designations: 177 Lu-MAC0, 177 Lu-MAC1 and 177 Lu-MAC2. Results: In vivo evaluation of the 177 Lu-MACs was performed in an HPAC human pancreatic cancer xenograft mouse model. 177 Lu-MAC1 and 177 Lu-MAC2 demonstrated 3.1 and 2.1 fold lower liver retention, respectively, compared to control ( 177 Lu-MAC0) at 72 h post-injection. With regard to spleen retention, 177 Lu-MAC1 and 177 Lu-MAC2 each exhibited a nearly fourfold lower retention, relative to control, at the 72 h time point. However, the tumor accumulation of the 177 Lu-MAC0 was two to three times greater than 177 Lu-MAC1 and 177 Lu-MAC2 at the same time point. The MAL approach demonstrated the capability of substantially reducing the non-target retention of the 177 Lu-labeled HPMA copolymers. Conclusions: While further studies are needed to optimize the

  16. {sup 177}Lu-DOTMP: a viable agent for palliative radiotherapy of painful bone metastasis

    Energy Technology Data Exchange (ETDEWEB)

    Das, T.; Chakraborty, S.; Banerjee, S. [Radiopharmaceuticals Div., Bhabha Atomic Research Centre, Mumbai (India); Sarma, H.D. [Radiation Biology and Health Sciences Div., Bhabha Atomic Research Centre, Mumbai (India)

    2008-07-01

    The suitable nuclear decay characteristics [T{sub 1/2} = 6.73 d, E{sub {beta}}{sub (max)} = 497 keV, E{sub {gamma}} = 113 keV (6.4%), 208 keV (11%)] as well as the feasibility of large-scale production with adequate specific activity and radionuclidic purity using a moderate flux reactor are important attributes towards {sup 177}Lu to be considered as a promising radionuclide for palliative care in painful bone metastasis. The present study describes the preparation of {sup 177}Lu complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonic acid (DOTMP) and its preliminary biological evaluation in animal models with an aim to proposing it as a viable radiopharmaceutical for bone pain palliation. The choice DOTMP as the polyaminophosphonic acid carrier ligand is based on the enhanced thermodynamic stability and kinetic inertness of the metal-ligand complexes with macrocyclic chelators. {sup 177}Lu was produced with a specific activity of {proportional_to} 12 GBq/mg ({proportional_to} 324 mCi/mg) and radionuclidic purity of 99.98% by irradiation of natural Lu{sub 2}O{sub 3} target at a thermal neutron flux of {proportional_to} 6 x 10{sup 13} n/cm{sup 2} s for 21 d. {sup 177}Lu-DOTMP complex was prepared in high yield and excellent radiochemical purity (> 99%) using DOTMP synthesized and characterized in-house. The complex exhibited excellent in-vitro stability at room temperature. Biodistribution studies in Wistar rats showed rapid skeletal accumulation of the injected activity [(1.60{+-}0.19)% per gram in femur at 3 h post-injection] with fast clearance from blood and minimal uptake in any of the major organs. Scintigraphic studies carried out in normal Wistar rats and New Zealand white rabbits also demonstrated significant accumulation of the agent in skeleton and almost no retention in any other vital organs. (orig.)

  17. Metastatic Bone Pain Palliation using 177Lu-Ethylenediaminetetramethylene Phosphonic Acid

    International Nuclear Information System (INIS)

    Alavi, Mehrosadat; Omidvari, Shapour; Mehdizadeh, Alireza; Jalilian, Amir R.; Bahrami-Samani, Ali

    2015-01-01

    177 Lu-ethylenediaminetetramethylene phosphonic acid (EDTMP) is presently suggested as an excellent bone seeking radionuclide for developing metastatic bone pain (MBP) palliation agent owing to its suitable nuclear decay characteristics. To find the exact dosage and its efficiency, this clinical study was performed on the human being, using 177 Lu-EDTMP for MBP palliation. 177 Lu-EDTMP was prepared by Iran, atomic energy organization. Thirty consecutive patients with determined tumors, incontrollable MBP, and positive bone scan at 4 weeks before the beginning of the study participated in this study in the nuclear medicine ward. 177 Lu-EDTMP in the form of sterile slow IV injection was administered with a dose of 29.6 MBq/kg. Short form of brief pain inventory questionnaire was used to evaluate the efficiency of the intervention. Questionnaires were filled out by an expert nuclear physician every 2 weeks while the cell blood count was also checked every 2 weeks up to 12 weeks for evaluation of bone marrow suppression and hematological toxicity. Furthermore, whole body scan was done at days 1, 3, and 7. Twenty-five patients showed a significant pain relief since 2 weeks after the injection, and continued until the end of the follow up period (12 weeks). There were no significant early complications such as bone marrow suppression, hematological toxicity, and no systemic adverse effects. No complication was observed in renal function. Twenty one patients showed flare phenomenon that was started after the 12.2 ± 1.78 h lasting for 38.4 ± 23.08. Sixteen patients (53%) were completely treated; nine patients (30%) showed a partial response, and five patients (17%) had no response to treatment. Total response to treatment was achieved in 25 patients (83%). At the end of the evaluation, no bone marrow suppression or hematologic toxicity was observed. 177 Lu-EDTMP has shown suitable physical and biological properties with good results in long term bone pain relief for

  18. Metastatic Bone Pain Palliation using (177)Lu-Ethylenediaminetetramethylene Phosphonic Acid.

    Science.gov (United States)

    Alavi, Mehrosadat; Omidvari, Shapour; Mehdizadeh, Alireza; Jalilian, Amir R; Bahrami-Samani, Ali

    2015-01-01

    (177)Lu-ethylenediaminetetramethylene phosphonic acid (EDTMP) is presently suggested as an excellent bone seeking radionuclide for developing metastatic bone pain (MBP) palliation agent owing to its suitable nuclear decay characteristics. To find the exact dosage and its efficiency, this clinical study was performed on the human being, using (177)Lu-EDTMP for MBP palliation. (177)Lu-EDTMP was prepared by Iran, atomic energy organization. Thirty consecutive patients with determined tumors, incontrollable MBP, and positive bone scan at 4 weeks before the beginning of the study participated in this study in the nuclear medicine ward. (177)Lu-EDTMP in the form of sterile slow IV injection was administered with a dose of 29.6 MBq/kg. Short form of brief pain inventory questionnaire was used to evaluate the efficiency of the intervention. Questionnaires were filled out by an expert nuclear physician every 2 weeks while the cell blood count was also checked every 2 weeks up to 12 weeks for evaluation of bone marrow suppression and hematological toxicity. Furthermore, whole body scan was done at days 1, 3, and 7. Twenty-five patients showed a significant pain relief since 2 weeks after the injection, and continued until the end of the follow up period (12 weeks). There were no significant early complications such as bone marrow suppression, hematological toxicity, and no systemic adverse effects. No complication was observed in renal function. Twenty one patients showed flare phenomenon that was started after the 12.2 ± 1.78 h lasting for 38.4 ± 23.08. Sixteen patients (53%) were completely treated; nine patients (30%) showed a partial response, and five patients (17%) had no response to treatment. Total response to treatment was achieved in 25 patients (83%). At the end of the evaluation, no bone marrow suppression or hematologic toxicity was observed. (177)Lu-EDTMP has shown suitable physical and biological properties with good results in long term bone pain relief for

  19. Metastatic Bone Pain Palliation using 177Lu-Ethylenediaminetetramethylene Phosphonic Acid

    Science.gov (United States)

    Alavi, Mehrosadat; Omidvari, Shapour; Mehdizadeh, Alireza; Jalilian, Amir R.; Bahrami-Samani, Ali

    2015-01-01

    177Lu-ethylenediaminetetramethylene phosphonic acid (EDTMP) is presently suggested as an excellent bone seeking radionuclide for developing metastatic bone pain (MBP) palliation agent owing to its suitable nuclear decay characteristics. To find the exact dosage and its efficiency, this clinical study was performed on the human being, using 177Lu-EDTMP for MBP palliation. 177Lu-EDTMP was prepared by Iran, atomic energy organization. Thirty consecutive patients with determined tumors, incontrollable MBP, and positive bone scan at 4 weeks before the beginning of the study participated in this study in the nuclear medicine ward. 177Lu-EDTMP in the form of sterile slow IV injection was administered with a dose of 29.6 MBq/kg. Short form of brief pain inventory questionnaire was used to evaluate the efficiency of the intervention. Questionnaires were filled out by an expert nuclear physician every 2 weeks while the cell blood count was also checked every 2 weeks up to 12 weeks for evaluation of bone marrow suppression and hematological toxicity. Furthermore, whole body scan was done at days 1, 3, and 7. Twenty-five patients showed a significant pain relief since 2 weeks after the injection, and continued until the end of the follow up period (12 weeks). There were no significant early complications such as bone marrow suppression, hematological toxicity, and no systemic adverse effects. No complication was observed in renal function. Twenty one patients showed flare phenomenon that was started after the 12.2 ± 1.78 h lasting for 38.4 ± 23.08. Sixteen patients (53%) were completely treated; nine patients (30%) showed a partial response, and five patients (17%) had no response to treatment. Total response to treatment was achieved in 25 patients (83%). At the end of the evaluation, no bone marrow suppression or hematologic toxicity was observed. 177Lu-EDTMP has shown suitable physical and biological properties with good results in long term bone pain relief for patients

  20. Subacute haematotoxicity after PRRT with {sup 177}Lu-DOTA-octreotate: prognostic factors, incidence and course

    Energy Technology Data Exchange (ETDEWEB)

    Bergsma, Hendrik; Konijnenberg, Mark W.; Kam, Boen L.R.; Teunissen, Jaap J.M.; Kooij, Peter P.; Krenning, Eric P.; Kwekkeboom, Dik J. [Erasmus University Medical Center, Department of Nuclear Medicine, Rotterdam (Netherlands); Herder, Wouter W. de [Erasmus Medical Center, Department of Internal Medicine, Rotterdam (Netherlands); Franssen, Gaston J.H.; Eijck, Casper H.J. van [Erasmus Medical Center, Department of Surgery, Rotterdam (Netherlands)

    2016-03-15

    In peptide receptor radionuclide therapy (PRRT), the bone marrow (BM) is one of the dose-limiting organs. The accepted dose limit for BM is 2 Gy, adopted from {sup 131}I treatment. We investigated the incidence and duration of haematological toxicity and its risk factors in patients treated with PRRT with {sup 177}Lu-DOTA{sup 0}-Tyr{sup 3}-octreotate ({sup 177}Lu-DOTATATE). Also, absorbed BM dose estimates were evaluated and compared with the accepted 2 Gy dose limit. The incidence and duration of grade 3 or 4 haematological toxicity (according to CTCAE v3.0) and risk factors were analysed. Mean BM dose per unit (gigabecquerels) of administered radioactivity was calculated and the correlations between doses to the BM and haematological risk factors were determined. Haematological toxicity (grade 3/4) occurred in 34 (11 %) of 320 patients. In 15 of the 34 patients, this lasted more than 6 months or blood transfusions were required. Risk factors significantly associated with haematological toxicity were: poor renal function, white blood cell (WBC) count <4.0 x 10{sup 9}/l, age over 70 years, extensive tumour mass and high tumour uptake on the OctreoScan. Previous chemotherapy was not associated. The mean BM dose per administered activity in 23 evaluable patients was 67 ± 7 mGy/GBq, resulting in a mean BM dose of 2 Gy in patients who received four cycles of 7.4 GBq {sup 177}Lu-DOTATATE. Significant correlations between (cumulative) BM dose and platelet and WBC counts were found in a selected group of patients. The incidence of subacute haematological toxicity after PRRT with {sup 177}Lu-DOTATATE is acceptable (11 %). Patients with impaired renal function, low WBC count, extensive tumour mass, high tumour uptake on the OctreoScan and/or advanced age are more likely to develop grade 3/4 haematological toxicity. The BM dose limit of 2 Gy, adopted from {sup 131}I, seems not to be valid for PRRT with {sup 177}Lu-DOTATATE. (orig.)

  1. Plastics recycling: challenges and opportunities.

    Science.gov (United States)

    Hopewell, Jefferson; Dvorak, Robert; Kosior, Edward

    2009-07-27

    Plastics are inexpensive, lightweight and durable materials, which can readily be moulded into a variety of products that find use in a wide range of applications. As a consequence, the production of plastics has increased markedly over the last 60 years. However, current levels of their usage and disposal generate several environmental problems. Around 4 per cent of world oil and gas production, a non-renewable resource, is used as feedstock for plastics and a further 3-4% is expended to provide energy for their manufacture. A major portion of plastic produced each year is used to make disposable items of packaging or other short-lived products that are discarded within a year of manufacture. These two observations alone indicate that our current use of plastics is not sustainable. In addition, because of the durability of the polymers involved, substantial quantities of discarded end-of-life plastics are accumulating as debris in landfills and in natural habitats worldwide. Recycling is one of the most important actions currently available to reduce these impacts and represents one of the most dynamic areas in the plastics industry today. Recycling provides opportunities to reduce oil usage, carbon dioxide emissions and the quantities of waste requiring disposal. Here, we briefly set recycling into context against other waste-reduction strategies, namely reduction in material use through downgauging or product reuse, the use of alternative biodegradable materials and energy recovery as fuel. While plastics have been recycled since the 1970s, the quantities that are recycled vary geographically, according to plastic type and application. Recycling of packaging materials has seen rapid expansion over the last decades in a number of countries. Advances in technologies and systems for the collection, sorting and reprocessing of recyclable plastics are creating new opportunities for recycling, and with the combined actions of the public, industry and governments it

  2. Plastics recycling: challenges and opportunities

    Science.gov (United States)

    Hopewell, Jefferson; Dvorak, Robert; Kosior, Edward

    2009-01-01

    Plastics are inexpensive, lightweight and durable materials, which can readily be moulded into a variety of products that find use in a wide range of applications. As a consequence, the production of plastics has increased markedly over the last 60 years. However, current levels of their usage and disposal generate several environmental problems. Around 4 per cent of world oil and gas production, a non-renewable resource, is used as feedstock for plastics and a further 3–4% is expended to provide energy for their manufacture. A major portion of plastic produced each year is used to make disposable items of packaging or other short-lived products that are discarded within a year of manufacture. These two observations alone indicate that our current use of plastics is not sustainable. In addition, because of the durability of the polymers involved, substantial quantities of discarded end-of-life plastics are accumulating as debris in landfills and in natural habitats worldwide. Recycling is one of the most important actions currently available to reduce these impacts and represents one of the most dynamic areas in the plastics industry today. Recycling provides opportunities to reduce oil usage, carbon dioxide emissions and the quantities of waste requiring disposal. Here, we briefly set recycling into context against other waste-reduction strategies, namely reduction in material use through downgauging or product reuse, the use of alternative biodegradable materials and energy recovery as fuel. While plastics have been recycled since the 1970s, the quantities that are recycled vary geographically, according to plastic type and application. Recycling of packaging materials has seen rapid expansion over the last decades in a number of countries. Advances in technologies and systems for the collection, sorting and reprocessing of recyclable plastics are creating new opportunities for recycling, and with the combined actions of the public, industry and governments it

  3. Peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors: First comparative results using the somatostatin analogues Lu-177 DOTA-NOC and Lu-177 DOTA-TATE

    International Nuclear Information System (INIS)

    Wehrmann, C.; Senftleben, S.; Baum, R.P.

    2005-01-01

    Peptide receptor radionuclide therapy (PRRT) is used in our department since 5 years (approx. 400 applications) for the treatment of patients with metastatic neuroendocrine tumors. Of all known peptides, the somatostatin analogue DOTA-NOC shows in vitro the highest affinity to somatostatin receptors (sstr) 3 and 5 and a very high affinity to sstr 2. We studied the in vivo behaviour of the two peptides DOTA-NOC and DOTA-TATE (highest affinity to sstr 2) by the use of different parameters like tumor and organ uptake, effective half-lifes (kinetics) and mean absorbed organ and tumor doses. We studied 27 patients with metastatic neuroendocrine tumors with high somatostatin expression, as verified prior to treatment by Ga-68 DOTA-NOC receptor PET/CT or somatostatin receptor scintigraphy (Tc-99m EDDA-Hynic TOC or In-111 OctreoScan, planar and SPECT). 22 patients (8M and 14F; aged 619 years) were treated with 2500 6790 MBq Lu-177 DOTA-TATE. Another 5 patients (1M and 4F, aged 6310 years) were treated with 4000 7400 MBq Lu-177 DOTA-NOC. Labelling efficiency and radiochemical purity using Lutetium-177 chloride (obtained from PerkinElmer Life Sciences, USA) were constantly over 99.5%. Whole-body scans (anterior/posterior) were performed at 0.5h, 3h, 24h, 48h, 72h and 96h p.i. ROIs were drawn over the whole-body, organs, and different metastases (mainly in the liver). Blood samples were obtained in 12 patients after therapy with Lu-177 DOTA-TATE over 5 days for calculating the kinetics in blood. The ROI results were used to determine the uptake and effective half-life in different organs (kidney, spleen, liver, bone etc.) and the tumor residence times. By means of geometric mean, and after background correction, the ROI results were also used to calculate the estimated absorbed organ and tumor doses using the OLINDA software. Compared to Lu-177 DOTA-TATE (=100%), the uptake of Lu-177 DOTA-NOC was higher for the whole-body (45%) and for normal tissues (28%), and also in the

  4. Sustainable reverse logistics for household plastic waste

    NARCIS (Netherlands)

    Bing, X.

    2014-01-01

    Summary of the thesis titled “Sustainable Reverse Logistics for Household Plastic Waste”

    PhD Candidate: Xiaoyun Bing

    Recycled plastic can be used in the manufacturing of plastic products to reduce the use of virgin plastics material. The cost of recycled plastics is usually lower

  5. Plastics for corrosion inhibition

    CERN Document Server

    Goldade, Victor A; Makarevich, Anna V; Kestelman, Vladimir N

    2005-01-01

    The development of polymer composites containing inhibitors of metal corrosion is an important endeavour in modern materials science and technology. Corrosion inhibitors can be located in a polymer matrix in the solid, liquid or gaseous phase. This book details the thermodynamic principles for selecting these components, their compatibility and their effectiveness. The various mechanisms of metal protection – barrier, inhibiting and electromechanical – are considered, as are the conflicting requirements placed on the structure of the combined material. Two main classes of inhibited materials (structural and films/coatings) are described in detail. Examples are given of structural plastics used in friction units subjected to mechano-chemical wear and of polymer films/coatings for protecting metal objects against corrosion.

  6. Antitenascin antibody 81C6 armed with {sup 177}Lu: in vivo comparison of macrocyclic and acyclic ligands

    Energy Technology Data Exchange (ETDEWEB)

    Yordanov, Alexander T. [Department of Radiology, Duke University Medical Center Durham, NC 27710 (United States); Hens, Marc [Department of Radiology, Duke University Medical Center Durham, NC 27710 (United States); Pegram, Charles [Department of Pathology, Duke University Medical Center Durham, NC 27710 (United States); Bigner, Darell D. [Department of Pathology, Duke University Medical Center Durham, NC 27710 (United States); Zalutsky, Michael R. [Department of Radiology, Duke University Medical Center Durham, NC 27710 (United States)]. E-mail: zalut001@mc.duke.edu

    2007-02-15

    Introduction: When labeled with iodine-131, the antitenascin monoclonal antibody (mAb) 81C6 has shown promise as a targeted radiotherapeutic in patients with brain tumors. Because of its more favorable {gamma}-ray properties, lutetium-177 might be a better low-energy {beta}-emitter for this type of therapy. Materials and Methods: Chimeric 81C6 (ch81C6) was labeled with {sup 177}Lu using the acyclic 1B4M ligand and the macrocyclic ligands NHS-DOTA and MeO-DOTA and evaluated for binding to tenascin. Three paired-label tissue distribution experiments were performed in normal mice receiving one of the {sup 177}Lu-labeled immunoconjugates plus {sup 125}I-labeled ch81C6 labeled using Iodogen. Paired-label experiments in athymic mice bearing subcutaneous D54 MG human glioma xenografts were done to directly compare the biodistribution of ch81C6-1B4M-{sup 177}Lu and {sup 125}I-labeled ch81C6, and ch81C6-MeO-DOTA-{sup 177}Lu and {sup 125}I-labeled ch81C6. Similar comparisons were done using murine (mu) instead of ch81C6. The primary parameter utilized for evaluation was the {sup 177}Lu/{sup 125}I uptake ratio in each tissue. Results: In the studies performed in normal mice, the NHS-DOTA ligand yielded the highest {sup 177}Lu/{sup 125}I uptake ratios in tissues indicative of loss of label from the chelate; for this reason, only 1B4M and MeO-DOTA were evaluated further. The {sup 177}Lu/{sup 125}I ratio in bone increased gradually with time for the chimeric conjugates; however, there were no significant differences between ch81C6-1B4M-DTPA-{sup 177}Lu and ch81C6-MeO-DOTA-{sup 177}Lu. In contrast, mu81C6-1B4M-DTPA-{sup 177}Lu and mu81C6-MeO-DOTA-{sup 177}Lu showed a more dramatic increase in the {sup 177}Lu/{sup 125}I ratio in bone - from 2.4{+-}0.3 and 1.7{+-}0.2 at Day 1 to 8.5{+-}1.1 and 4.2{+-}0.5 at Day 7, respectively. Conclusion: With these antitenascin constructs, the nature of the mAb had a profound influence on the relative degree of loss of {sup 177}Lu from these

  7. Nigerian Journal of Plastic Surgery

    African Journals Online (AJOL)

    The Nigerian Journal of Plastic Surgery has its objectives in publishing original articles about developments in all areas related to plastic and reconstructive surgery as well as to trauma surgery. It also serves as a means of providing a forum for correspondence, information and discussion. It also accepts review articles that ...

  8. Architecture of European Plastic Surgery

    NARCIS (Netherlands)

    Nicolai, J. -P. A.; Banic, A.; Molea, G.; Mazzola, R.; Poell, J. G.

    2006-01-01

    The architecture of European Plastic Surgery was published in 1996 [Nicolai JPA, Scuderi N. Plastic surgical Europe in an organogram. Eur J Plast Surg 1996; 19: 253-6.] It is the objective of this paper to update information of that article. Continuing medical education (CME), science, training,

  9. Imaging brain plasticity after trauma

    Institute of Scientific and Technical Information of China (English)

    Zhifeng Kou; Armin Iraji

    2014-01-01

    The brain is highly plastic after stroke or epilepsy;however, there is a paucity of brain plasticity investigation after traumatic brain injury (TBI). This mini review summarizes the most recent evidence of brain plasticity in human TBI patients from the perspective of advanced magnetic resonance imaging. Similar to other forms of acquired brain injury, TBI patients also demonstrat-ed both structural reorganization as well as functional compensation by the recruitment of other brain regions. However, the large scale brain network alterations after TBI are still unknown, and the ifeld is still short of proper means on how to guide the choice of TBI rehabilitation or treat-ment plan to promote brain plasticity. The authors also point out the new direction of brain plas-ticity investigation.

  10. Size effects in crystal plasticity

    DEFF Research Database (Denmark)

    Borg, Ulrik

    2007-01-01

    Numerical analyses of plasticity size effects have been carried out for different problems using a developed strain gradient crystal plasticiy theory. The theory employs higher order stresses as work conjugates to slip gradients and uses higher order boundary conditions. Problems on localization...... of plastic flow in a single crystal, grain boundary effects in a bicrystal, and grain size effects in a polycrystal are studied. Single crystals containing micro-scale voids have also been analyzed at different loading conditions with focus on the stress and deformation fields around the voids, on void...... growth and interaction between neighboring voids, and on a comparison between the developed strain gradient crystal plasticity theory and a discrete dislocation plasticity theory. Furthermore, voids and rigid inclusions in isotropic materials have been studied using a strain gradient plasticity theory...

  11. Computational strain gradient crystal plasticity

    DEFF Research Database (Denmark)

    Niordson, Christian Frithiof; Kysar, Jeffrey W.

    2014-01-01

    A numerical method for viscous strain gradient crystal plasticity theory is presented, which incorporates both energetic and dissipative gradient effects. The underlying minimum principles are discussed as well as convergence properties of the proposed finite element procedure. Three problems...... of plane crystal plasticity are studied: pure shear of a single crystal between rigid platens as well as plastic deformation around cylindrical voids in hexagonal close packed and face centered cubic crystals. Effective in-plane constitutive slip parameters for plane strain deformation of specifically...... oriented face centered cubic crystals are developed in terms of the crystallographic slip parameters. The effect on geometrically necessary dislocation structures introduced by plastic deformation is investigated as a function of the ratio of void radius to plasticity length scale....

  12. Grain Interactions in Crystal Plasticity

    International Nuclear Information System (INIS)

    Boyle, K.P.; Curtin, W.A.

    2005-01-01

    The plastic response of a sheet metal is governed by the collective response of the underlying grains. Intragranular plasticity depends on intrinsic variables such as crystallographic orientation and on extrinsic variables such as grain interactions; however, the role of the latter is not well understood. A finite element crystal plasticity formulation is used to investigate the importance of grain interactions on intragranular plastic deformation in initially untextured polycrystalline aggregates. A statistical analysis reveals that grain interactions are of equal (or more) importance for determining the average intragranular deviations from the applied strain as compared to the orientation of the grain itself. Furthermore, the influence of the surrounding grains is found to extend past nearest neighbor interactions. It is concluded that the stochastic nature of the mesoscale environment must be considered for a proper understanding of the plastic response of sheet metals at the grain-scale

  13. Synthesis of oligosaccharides derived from lactulose (OsLu using soluble and immobilized Aspergillus oryzae b-galactosidase

    Directory of Open Access Journals (Sweden)

    ALEJANDRA eCARDELLE COBAS

    2016-03-01

    Full Text Available b-galactosidase from Aspergillus oryzae offers a high yield for the synthesis of oligosaccharides derived from lactulose (OsLu by transgalactosylation. Oligosaccharides with degree of polymerization (DP ≥ 3 have shown to possess higher in vitro bifidogenic effect than di- and tetrasaccharides. Thus, in this work, an optimization of reaction conditions affecting the specific selectivity of A. oryzae b-galactosidase for synthesis of OsLu has been carried out to enhance OsLu with DP ≥ 3 production. Assays with b-galactosidase immobilized onto a glutaraldehyde-agarose support were also carried out with the aim of making the process cost-effective and industrially viable. Optimal conditions with both soluble and immobilized enzyme for the synthesis of OsLu with DP ≥ 3 were 50 °C, pH 6.5, 450 g/L of lactulose and 8 U/mL of enzyme, reaching yields of ca. 50% (w/v of total OsLu and ca. 20% (w/v of OsLu-3, being 6′-galactosyl-lactulose the major one, after a short reaction time. Selective formation of disaccharides, however, was favored at 60 °C, pH 4.5, 450 g/L of lactulose and 8 U/mL of enzyme. Immobilization increased the enzymatic stability to temperature changes and allowed to reuse the enzyme. We can conclude that the use, under determined optimal conditions, of the A. oryzae b-galactosidase immobilized on a support of glutaraldehyde-agarose constitutes an efficient and cost-effective alternative to the use of soluble b-galactosidases for the synthesis of prebiotic OsLu mixtures.

  14. 68Ga/177Lu-labeled DOTA-TATE shows similar imaging and biodistribution in neuroendocrine tumor model.

    Science.gov (United States)

    Liu, Fei; Zhu, Hua; Yu, Jiangyuan; Han, Xuedi; Xie, Qinghua; Liu, Teli; Xia, Chuanqin; Li, Nan; Yang, Zhi

    2017-06-01

    Somatostatin receptors are overexpressed in neuroendocrine tumors, whose endogenous ligands are somatostatin. DOTA-TATE is an analogue of somatostatin, which shows high binding affinity to somatostatin receptors. We aim to evaluate the 68 Ga/ 177 Lu-labeling DOTA-TATE kit in neuroendocrine tumor model for molecular imaging and to try human-positron emission tomography/computed tomography imaging of 68 Ga-DOTA-TATE in neuroendocrine tumor patients. DOTA-TATE kits were formulated and radiolabeled with 68 Ga/ 177 Lu for 68 Ga/ 177 Lu-DOTA-TATE (M-DOTA-TATE). In vitro and in vivo stability of 177 Lu-DOTA-TATE were performed. Nude mice bearing human tumors were injected with 68 Ga-DOTA-TATE or 177 Lu-DOTA-TATE for micro-positron emission tomography and micro-single-photon emission computed tomography/computed tomography imaging separately, and clinical positron emission tomography/computed tomography images of 68 Ga-DOTA-TATE were obtained at 1 h post-intravenous injection from patients with neuroendocrine tumors. Micro-positron emission tomography and micro-single-photon emission computed tomography/computed tomography imaging of 68 Ga-DOTA-TATE and 177 Lu-DOTA-TATE both showed clear tumor uptake which could be blocked by excess DOTA-TATE. In addition, 68 Ga-DOTA-TATE-positron emission tomography/computed tomography imaging in neuroendocrine tumor patients could show primary and metastatic lesions. 68 Ga-DOTA-TATE and 177 Lu-DOTA-TATE could accumulate in tumors in animal models, paving the way for better clinical peptide receptor radionuclide therapy for neuroendocrine tumor patients in Asian population.

  15. Nano-Ceramic Coated Plastics

    Science.gov (United States)

    Cho, Junghyun

    2013-01-01

    Plastic products, due to their durability, safety, and low manufacturing cost, are now rapidly replacing cookware items traditionally made of glass and ceramics. Despite this trend, some still prefer relatively expensive and more fragile ceramic/glassware because plastics can deteriorate over time after exposure to foods, which can generate odors, bad appearance, and/or color change. Nano-ceramic coatings can eliminate these drawbacks while still retaining the advantages of the plastic, since the coating only alters the surface of the plastic. The surface coating adds functionality to the plastics such as self-cleaning and disinfectant capabilities that result from a photocatalytic effect of certain ceramic systems. These ceramic coatings can also provide non-stick surfaces and higher temperature capabilities for the base plastics without resorting to ceramic or glass materials. Titanium dioxide (TiO2) and zinc oxide (ZnO) are the candidates for a nano-ceramic coating to deposit on the plastics or plastic films used in cookware and kitchenware. Both are wide-bandgap semiconductors (3.0 to 3.2 eV for TiO2 and 3.2 to 3.3 eV for ZnO), so they exhibit a photocatalytic property under ultraviolet (UV) light. This will lead to decomposition of organic compounds. Decomposed products can be easily washed off by water, so the use of detergents will be minimal. High-crystalline film with large surface area for the reaction is essential to guarantee good photocatalytic performance of these oxides. Low-temperature processing (nano-ceramic coatings (TiO2, ZnO) on plastic materials (silicone, Teflon, PET, etc.) that can possess both photocatalytic oxide properties and flexible plastic properties. Processing cost is low and it does not require any expensive equipment investment. Processing can be scalable to current manufacturing infrastructure.

  16. Yb:Lu{sub 2}O{sub 3} hydrothermally-grown single-crystal and ceramic absorption spectra obtained between 298 and 80 K

    Energy Technology Data Exchange (ETDEWEB)

    Moore, Cheryl A. [Snake Creek Lasers LLC, 26741 State Route 267, Friendsville, PA 18818 (United States); Department of Chemistry and Center for Optical Materials Science and Engineering Technologies, Clemson University, Clemson, SC 29634-0973 (United States); Brown, David C., E-mail: dbrown@snakecreeklasers.com [Snake Creek Lasers LLC, 26741 State Route 267, Friendsville, PA 18818 (United States); Sanjeewa, Liurukara D.; McMillen, Colin D.; Kolis, Joseph W. [Department of Chemistry and Center for Optical Materials Science and Engineering Technologies, Clemson University, Clemson, SC 29634-0973 (United States)

    2016-06-15

    The hydrothermal growth, doping, and low temperature spectral characterization of Yb doped Lu{sub 2}O{sub 3} was investigated. The absorption of the lutetia-based sesquioxide laser material Yb:Lu{sub 2}O{sub 3} at temperatures of 80, 150, 200, 250, and 298 K, in the wavelength range of 850–1100 nm are reported. Data for both single crystal and ceramic Yb:Lu{sub 2}O{sub 3} were obtained. The resulting absorption cross-section data will enable the further evaluation of Yb:Lu{sub 2}O{sub 3} as a very promising high power cryogenic laser material.

  17. 177Lu-DOTA-HH1, a novel anti-CD37 radio-immunoconjugate: a study of toxicity in nude mice.

    Directory of Open Access Journals (Sweden)

    Ada H V Repetto-Llamazares

    Full Text Available CD37 is an internalizing B-cell antigen expressed on Non-Hodgkin lymphoma (NHL and chronic lymphocytic leukemia cells (CLL. The anti-CD37 monoclonal antibody HH1 was conjugated to the bifunctional chelator p-SCN-Bn-DOTA and labelled with the beta-particle emitting radionuclide 177Lu creating the radio-immunoconjugate (RIC 177Lu-DOTA-HH1 (177Lu-HH1, trade name Betalutin. The present toxicity study was performed prior to initiation of clinical studies with 177Lu-HH1.Nude mice with or without tumor xenografts were treated with 50 to 1000 MBq/kg 177Lu- HH1 and followed for clinical signs of toxicity up to ten months. Acute, life threatening bone marrow toxicity was observed in animals receiving 800 and 1000 MBq/kg 177Lu-HH1. Significant changes in serum concentrations of liver enzymes were evident for treatment with 1000 MBq/kg 177Lu-HH1. Lymphoid depletion, liver necrosis and atrophy, and interstitial cell hyperplasia of the ovaries were also observed for mice in this dose group.177Lu-DOTA-HH1 was well tolerated at dosages about 10 times above those considered relevant for radioimmunotherapy in patients with B-cell derived malignancies.The toxicity profile was as expected for RICs. Our experimental results have paved the way for clinical evaluation of 177Lu-HH1 in NHL patients.

  18. Charge, spin and orbital order in the candidate multiferroic material LuFe2O4

    International Nuclear Information System (INIS)

    Groot, Joost de

    2012-01-01

    This thesis is a detailed study of the magnetic, structural and orbital order parameters of the candidate multiferroic material LuFe 2 O 4 . Multiferroic oxides with a strong magnetoelectric coupling are of high interest for potential information technology applications, but they are rare because the traditional mechanism of ferroelectricity is incompatible with magnetism. Consequently, much attention is focused on various unconventional mechanisms of ferroelectricity. Of these, ferroelectricity originating from charge ordering (CO) is particularly intriguing because it potentially combines large electric polarizations with strong magneto-electric coupling. However, examples of oxides where this mechanism occurs are exceedingly rare and none is really well understood. LuFe 2 O 4 is often cited as the prototypical example of CO-based ferroelectricity. In this material, the order of Fe valences has been proposed to render the triangular Fe/O bilayers polar by making one of the two layers rich in Fe 2+ and the other rich in Fe 3+ , allowing for a possible ferroelectric stacking of the individual bilayers. Because of this new mechanism for ferroelectricity, and also because of the high transition temperatures of charge order (T CO ∝320K) and ferro magnetism (T N ∝240 K) LuFe 2 O 4 has recently attracted increasing attention. Although these polar bilayers are generally accepted in the literature for LuFe 2 O 4 , direct proof is lacking. An assumption-free experimental determination of whether or not the CO in the Fe/O bilayers is polar would be crucial, given the dependence of the proposed mechanism of ferroelectricity from CO in LuFe 2 O 4 on polar bilayers. This thesis starts with a detailed characterization of the macroscopic magnetic properties, where growing ferrimagnetic contributions observed in magnetization could be ascribed to increasing oxygen off-stoichiometry. The main focus is on samples exhibiting a sharp magnetic transition to long-range spin order

  19. Evaluation of 177Lu[Lu]-CHX-A″-DTPA-6A10 Fab as a radioimmunotherapy agent targeting carbonic anhydrase XII.

    Science.gov (United States)

    Fiedler, L; Kellner, M; Gosewisch, A; Oos, R; Böning, G; Lindner, S; Albert, N; Bartenstein, P; Reulen, H-J; Zeidler, R; Gildehaus, F J

    2018-05-01

    Due to their infiltrative growth behavior, gliomas have, even after surgical resection, a high recurrence tendency. The approach of intracavitary radioimmunotherapy (RIT) is aimed at inhibiting tumor re-growth by directly administering drugs into the resection cavity (RC). Direct application of the radioconjugate into the RC has the advantage of bypassing the blood-brain barrier, which allows the administration of higher radiation doses than systemic application. Carbonic anhydrase XII (CA XII) is highly expressed on glioma cells while being absent from normal brain and thus an attractive target molecule for RIT. We evaluated a CA XII-specific 6A10 Fab (fragment antigen binding) labelled with 177 Lu as an agent for RIT. 6A10 Fab fragment was modified and radiolabelled with 177 Lu and characterized by MALDI-TOF, flow cytometry and radio-TLC. In vitro stability was determined under physiological conditions. Biodistribution studies, autoradiography tumor examinations and planar scintigraphy imaging were performed on SCID-mice bearing human glioma xenografts. The in vitro CA XII binding capacity of the modified Fab was confirmed. Radiochemical purity was determined to be >90% after 72 h of incubation under physiological conditions. Autoradiography experiments proved the specific binding of the Fab to CA XII on tumor cells. Biodistribution studies revealed a tumor uptake of 3.0%ID/g after 6 h and no detectable brain uptake. The tumor-to-contralateral ratio of 10/1 was confirmed by quantitative planar scintigraphy. The radiochemical stability in combination with a successful in vivo tumor uptake shows the potential suitability for future RIT applications with the 6A10 Fab. Copyright © 2018 Elsevier Inc. All rights reserved.

  20. WOMEN’S PROBLEMATIC AT NOVELS BY AFET (MUHTEREMOĞLU ILGAZ AFET (MUHTEREMOĞLU ILGAZ’IN ROMANLARINDA KADIN SORUNSALI

    Directory of Open Access Journals (Sweden)

    Zehra YAZBAHAR

    2011-06-01

    Full Text Available From Tanzimat to Rebuclic, women were examined in various aspects by very important part of Turkish novelists. Women's place in society by men and women in second place among the questions the writers of Afet (Muhteremoğlu Ilgaz also mention the name.In this study, classified in terms of subject Afet Ilgaz’s novels after a brief introduction and overview of feminist discourse with the struggle for independence, the author traces of her novels had been discussed Tanzimat’tan Cumhuriyet dönemine kadar kadın konusu, çeşitli yönleriyle, Türk romancılarının önemli bir kısmı tarafından ele anılıp, incelenmiştir. Kadının toplum içindeki yerini ve kadının erkeğe göre ikinciliğini sorgulayan yazarlar arasında Afet (Muhteremoğlu Ilgaz’ın da ismi sayılabilir. Bu çalışmada, Afet Ilgaz’ın romanlarını konu bakımından sınıflandıran kısa bir girişten sonra yazarın romanlarında kadına bakış ve feminist söylemin izleri ile bağımsızlık ve varoluş mücadelesi ele alınmaya çalışıldı.

  1. Plasticity and beyond microstructures, crystal-plasticity and phase transitions

    CERN Document Server

    Hackl, Klaus

    2014-01-01

    The book presents the latest findings in experimental plasticity, crystal plasticity, phase transitions, advanced mathematical modeling of finite plasticity and multi-scale modeling. The associated algorithmic treatment is mainly based on finite element formulations for standard (local approach) as well as for non-standard (non-local approach) continua and for pure macroscopic as well as for directly coupled two-scale boundary value problems. Applications in the area of material design/processing are covered, ranging from grain boundary effects in polycrystals and phase transitions to deep-drawing of multiphase steels by directly taking into account random microstructures.

  2. International policies to reduce plastic marine pollution from single-use plastics (plastic bags and microbeads): A review.

    Science.gov (United States)

    Xanthos, Dirk; Walker, Tony R

    2017-05-15

    Marine plastic pollution has been a growing concern for decades. Single-use plastics (plastic bags and microbeads) are a significant source of this pollution. Although research outlining environmental, social, and economic impacts of marine plastic pollution is growing, few studies have examined policy and legislative tools to reduce plastic pollution, particularly single-use plastics (plastic bags and microbeads). This paper reviews current international market-based strategies and policies to reduce plastic bags and microbeads. While policies to reduce microbeads began in 2014, interventions for plastic bags began much earlier in 1991. However, few studies have documented or measured the effectiveness of these reduction strategies. Recommendations to further reduce single-use plastic marine pollution include: (i) research to evaluate effectiveness of bans and levies to ensure policies are having positive impacts on marine environments; and (ii) education and outreach to reduce consumption of plastic bags and microbeads at source. Copyright © 2017 Elsevier Ltd. All rights reserved.

  3. Water Vapor Permeation in Plastics

    Energy Technology Data Exchange (ETDEWEB)

    Keller, Paul E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Kouzes, Richard T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2017-01-01

    Polyvinyl toluene (PVT) and polystyrene (PS) (referred to as “plastic scintillator”) are used for gamma ray detectors. A significant decrease in radiation detection performance has been observed in some PVT-based gamma-ray detectors in systems in outdoor environments as they age. Recent studies have revealed that plastic scintillator can undergo an environmentally related material degradation that adversely affects gamma ray detection performance under certain conditions and histories. A significant decrease in sensitivity has been seen in some gamma-ray detectors in some systems as they age. The degradation of sensitivity of plastic scintillator over time is due to a variety of factors, and the term “aging” is used to encompass all factors. Some plastic scintillator samples show no aging effects (no significant change in sensitivity over more than 10 years), while others show severe aging (significant change in sensitivity in less than 5 years). Aging effects arise from weather (variations in heat and humidity), chemical exposure, mechanical stress, light exposure, and loss of volatile components. The damage produced by these various causes can be cumulative, causing observable damage to increase over time. Damage may be reversible up to some point, but becomes permanent under some conditions. The objective of this report is to document the phenomenon of permeability of plastic scintillator to water vapor and to derive the relationship between time, temperature, humidity and degree of water penetration in plastic. Several conclusions are documented about the properties of water permeability of plastic scintillator.

  4. Extruding plastic scintillator at Fermilab

    International Nuclear Information System (INIS)

    Pla-Dalmau, Anna; Bross, Alain D.; Rykalin, Viktor V.

    2003-01-01

    An understanding of the costs involved in the production of plastic scintillators and the development of a less expensive material have become necessary with the prospects of building very large plastic scintillation detectors. Several factors contribute to the high cost of plastic scintillating sheets, but the principal reason is the labor-intensive nature of the manufacturing process. In order to significantly lower the costs, the current casting procedures had to be abandoned. Since polystyrene is widely used in the consumer industry, the logical path was to investigate the extrusion of commercial-grade polystyrene pellets with dopants to yield high quality plastic scintillator. This concept was tested and high quality extruded plastic scintillator was produced. The D0 and MINOS experiments are already using extruded scintillator strips in their detectors. An extrusion line has recently been installed at Fermilab in collaboration with NICADD (Northern Illinois Center for Accelerator and Detector Development). This new facility will serve to further develop and improve extruded plastic scintillator. This paper will discuss the characteristics of extruded plastic scintillator and its raw materials, the different manufacturing techniques and the current R andD program at Fermilab

  5. Space Plastic Recycling System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Techshot's proposed Space Plastic Recycler (SPR) is an automated closed loop plastic recycling system that allows the automated conversion of disposable ISS...

  6. Radionuclide therapy with tissue factor targeting Lu-177-FVIIai inhibits growth in an experimental mouse model of human pancreatic cancer

    DEFF Research Database (Denmark)

    Nielsen, Carsten; Jensen, Mette; Fonslet, Jesper

    2017-01-01

    in several organs at 1, 4, 24, 72 and 168 hours after injection. The in vivo biodistribution of 177Lu-FVIIai was evaluated by SPECT/CT imaging. Furthermore, competition and dose escalation experiments (1-30 MBq) were performed. In a parallel set of NMRI mice, toxic effects of 177Lu-FVIIai were evaluated...... by hematology, histology and 99mTc-DMSA scintigraphy. Results: FVIIai was successfully radiolabeled with 177Lu with a specific activity of 10-25 GBq/µmol after EDTA scavenging and PD-10 purification. Treatment with FVIIai did not change tumor growth compared to the vehicle groups. The mice that received 15 MBq...... uptake of 177Lu-FVIIai measured ex vivo was 1.16±0.04, 1.97±0.18, 1.95±0.07, 1.01±0.06, 0.31±0.02 percent injected dose per gram (%ID/g) at 1, 4, 24, 72 and 168 hours post-injection, respectively. Injection with unlabeled FVIIai 10 minutes before 177Lu-FVIIai injection significantly reduced tumor uptake...

  7. Growth and laser characterization of a mixed laser crystal Nd: Lu 0.141Y 0.855VO 4

    Science.gov (United States)

    Zhao, Bin; Zhuang, Naifeng; Li, Tao; Guo, Feiyun; Zhuo, Zhuang; Ye, Jing; Chen, Jianzhong

    2011-11-01

    A new Nd: Lu 0.141Y 0.855VO 4 mixed laser crystal had been successfully grown by the Czochralski method. The reason of the crystal boule appearing additionally yellowish at the bottom was discussed. The X-ray powder diffraction analysis showed that the as-grown mixed crystal possesses the ZrSiO 4 structure. The effective segregation coefficients of Nd 3+ and Lu 3+ ions in the crystal were measured to be about 0.51 and 0.76, respectively. The room temperature fluorescence spectrum of the mixed crystal showed that the FWHM (full-width at half-maximum) of the 1064.9 nm fluorescence band was 5.1 nm, broader than that of Nd: YVO 4. A continuous-wave (CW) laser output was achieved with the Nd: Lu 0.141Y 0.855VO 4 crystal at 1.06 μm using laser diode pumping. The maximum CW output power of 1.7 W was obtained with the pump power of 7.6 W, higher than the 1.38 W achieved with the 0.5 at% Nd: LuVO 4 crystal under the same experimental conditions. All the results above show that the Nd: Lu 0.141Y 0.855VO 4 crystal is a promising laser material.

  8. The endogenous langur type D retrovirus PO-1-Lu and its exogenous counterparts in macaque and langur monkeys

    International Nuclear Information System (INIS)

    Sommerfelt, Maja A.; Harkestad, Nina; Hunter, Eric

    2003-01-01

    PO-1-Lu, the endogenous type D retrovirus of langurs (Trachypithecus obscurus) has previously been considered a progenitor to the prototype type D retrovirus, Mason Pfizer monkey virus (M-PMV/SRV-3), that became established in macaque monkeys (Macaca spp.) following a zoonosis. This study reevaluates this hypothesis to include other exogenous SRVs. New sequence information from the gp70(SU)-encoding region of PO-1-Lu shows striking similarity to the newly identified exogenous langur retrovirus, SRV-6, recently isolated from the Hanuman Langur (Semnopithecus entellus). An unrooted, bootstrapped neighbor-joining tree derived from env gene nucleotide sequences shows PO-1-Lu and SRV-6 appear more closely related genetically to SRV-2 than SRV-1 or SRV-3 (M-PMV). This is also reflected in our observations that the M-PMV envelope glycoprotein precursor gPr86 Env and gp70(SU) were antigenically distinct from PO-1-Lu, although the gp22(TM) glycoproteins were antigenically cross-reactive. The potential that SRV-6 represents an exogenous form of PO-1-Lu that has arisen following a recent zoonosis is discussed

  9. The research on biodistribution of bearing sarcoma mice and rabbit SPECT imaging of 177Lu-DOTMP

    International Nuclear Information System (INIS)

    Deng Xinrong; Xiang Xueqin; Li Fenglin; Fan Caiyun; Liu Zihua; Luo Zhifu; Chen Yang

    2012-01-01

    Cyclen (1, 4, 7, 10-tetraazacyclododecane) and H 3 PO 3 were used to synthesis DOTMP (1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-Tetraaminomethylenephosphonate), and then DOTMP was labelled with 177 Lu. The research of biodistribution of 177 Lu-DOTMP in model mice bearing S180 sarcoma and SPECT imaging in Japanese white rabbit were also carried out. The results of biodistribution of bearing S180 mice indicated that 177 Lu-DOTMP cleared rapidly from blood and was selectively delivered to target bone. The radioactivity uptake was mainly in bone and less in other organs and tissues. The results of SPECT imaging of Japanese white rabbit showed that the radioactivity was accumulated in bladder. 177 Lu-DOTMP was mainly excreted by kidney. The uptake of the activity in the skeleton was observed significantly within 22 h post-injection and it became quite significant at 46 h post-injection. It indicated that 177 Lu-DOTMP has good bone targeting and is worthy of further study. (authors)

  10. Comparative study of Tm-doped and Tm-Sc co-doped Lu3Al5O12 scintillator

    International Nuclear Information System (INIS)

    Sugiyama, Makoto; Yanagida, Takayuki; Fujimoto, Yutaka

    2014-01-01

    The crystals of Tm doped and Tm-Sc co-doped Lu 3 Al 5 O 12 (LuAG) grown by the floating zone (FZ) method were examined for their optical and scintillation properties. In transmittance spectra, strong absorption lines due to Tm 3+ 4f–4f transitions were observed. X-ray excited radioluminescence spectra were measured and broad and sharp emission peaks were detected. The former one was attributed to Sc 3+ and the latter one was due to Tm 3+ 4f–4f transitions. Scintillation yield enhancement due to Sc co-doping was observed by means of 137 Cs pulse height spectra. Scintillation decay times were several tens of μs under pulse X-ray excitation. - Highlights: • LuAG:Tm and LuAG:Tm, Sc single crystals have been grown by the FZ method. • Tm 3+ 4f–4f absorption has been observed in transmittance spectra. • Scintillation yield of Tm-doped LuAG has been enhanced by Sc co-doping

  11. Durability of wood plastic composites manufactured from recycled plastic

    Directory of Open Access Journals (Sweden)

    Irina Turku

    2018-03-01

    Full Text Available The influence of accelerated weathering, xenon-arc light and freeze-thaw cycling on wood plastic composites extruded from a recycled plastic was studied. The results showed that, in general, weathering had a stronger impact on samples made from plastic waste compared to a sample made from virgin material. After weathering, the mechanical properties, tensile and flexural, were reduced by 2–30%, depending on the plastic source. Wettability of the samples was shown to play a significant role in their stability. Chemical analysis with infrared spectroscopy and surface observation with a scan electron microscope confirmed the mechanical test results. Incorporation of carbon black retained the properties during weathering, reducing the wettability of the sample, diminishing the change of mechanical properties, and improving color stability. Keywords: Environmental science, Mechanical engineering, Materials science

  12. Phenotypic plasticity, costs of phenotypes, and costs of plasticity

    DEFF Research Database (Denmark)

    Callahan, Hilary S; Maughan, Heather; Steiner, Uli

    2008-01-01

    Why are some traits constitutive and others inducible? The term costs often appears in work addressing this issue but may be ambiguously defined. This review distinguishes two conceptually distinct types of costs: phenotypic costs and plasticity costs. Phenotypic costs are assessed from patterns...... of covariation, typically between a focal trait and a separate trait relevant to fitness. Plasticity costs, separable from phenotypic costs, are gauged by comparing the fitness of genotypes with equivalent phenotypes within two environments but differing in plasticity and fitness. Subtleties associated with both...... types of costs are illustrated by a body of work addressing predator-induced plasticity. Such subtleties, and potential interplay between the two types of costs, have also been addressed, often in studies involving genetic model organisms. In some instances, investigators have pinpointed the mechanistic...

  13. PET attenuation correction for rigid MR Tx/Rx coils from 176Lu background activity

    Science.gov (United States)

    Lerche, Christoph W.; Kaltsas, Theodoris; Caldeira, Liliana; Scheins, Jürgen; Rota Kops, Elena; Tellmann, Lutz; Pietrzyk, Uwe; Herzog, Hans; Shah, N. Jon

    2018-02-01

    One challenge for PET-MR hybrid imaging is the correction for attenuation of the 511 keV annihilation radiation by the required RF transmit and/or RF receive coils. Although there are strategies for building PET transparent Tx/Rx coils, such optimised coils still cause significant attenuation of the annihilation radiation leading to artefacts and biases in the reconstructed activity concentrations. We present a straightforward method to measure the attenuation of Tx/Rx coils in simultaneous MR-PET imaging based on the natural 176Lu background contained in the scintillator of the PET detector without the requirement of an external CT scanner or PET scanner with transmission source. The method was evaluated on a prototype 3T MR-BrainPET produced by Siemens Healthcare GmbH, both with phantom studies and with true emission images from patient/volunteer examinations. Furthermore, the count rate stability of the PET scanner and the x-ray properties of the Tx/Rx head coil were investigated. Even without energy extrapolation from the two dominant γ energies of 176Lu to 511 keV, the presented method for attenuation correction, based on the measurement of 176Lu background attenuation, shows slightly better performance than the coil attenuation correction currently used. The coil attenuation correction currently used is based on an external transmission scan with rotating 68Ge sources acquired on a Siemens ECAT HR  +  PET scanner. However, the main advantage of the presented approach is its straightforwardness and ready availability without the need for additional accessories.

  14. 卢作孚的伦理管理%Ethical Management of Lu Zuofu

    Institute of Scientific and Technical Information of China (English)

    王威

    2014-01-01

    Lu Zuofu implemented ethical management in Minsheng Corporation, took the realization of the overall modernization of China as the ethical objective of his company by making ethical decision for his company from the angle of serving the society and meanwhile by emphasizing the cultivation of the morality of his employees. Lu Zuofu, as the company manager, made himself an example and sticked to ethical leadship, which played a model role in the ethical selection of his employees. The ethical man-agement of Lu Zuofu made Minsheng Corporation have ethical advantage with unique characteristcs, which were further trans-formed into competitive advantage to forcefully ensure Minsheng Corporation to become the largest shipping group with Chinese private capital in modern China.%卢作孚在民生公司进行伦理管理,把帮助实现国家整体现代化作为公司的伦理目标,从服务社会的角度对公司进行伦理决策,同时重视员工的德性培育。卢作孚作为公司总经理以身垂范,坚持伦理领导,对员工的道德选择起到示范作用。卢作孚的伦理管理使民生公司形成独具特色的伦理优势,并进一步转化为竞争优势,有力地保证了公司发展成为近代中国最大的民族资本航运集团。

  15. Four-quasiparticle isomers and K-forbidden transitions in 176Lu

    International Nuclear Information System (INIS)

    McGoram, T.R.; Dracoulis, G.D.; Kibedi, T.; Mullins, M.; Byrne, A.P.; Baxter, A.M.

    2000-01-01

    Full text: The odd-odd nucleus 176 Lu has been the subject of extensive experimental and theoretical investigation over the last forty years. Much of this interest has stemmed from the role of 176 Lu in the s-process in nucleosynthesis. From a nuclear structure perspective, 176 Lu resides in a region of the nuclear chart where collective rotation and high-K, multi-quasiparticle states compete to form the yrast line (the locus of state with the lowest energy at a given angular momentum). The electromagnetic decay of intermediate and high-K states is often hindered due to the K-selection rule, while apparent violations of this selection rule have been ascribed to Coriolis mixing, shape changes in the gamma-degree of freedom, and so-called 'statistical' mixing. The relative importance of these mechanisms remains an open question. We present here the results of gamma-ray and conversion-electron spectroscopic measurements, performed at the Heavy Ion Facility at the Australian National University in Canberra, using the reaction 176 Yb( 7 Li, α3n) at a beam energy of 45 MeV. Two new four-quasiparticle isomers have been established, with mean lives of 400(100)ns and 58(5)μs, and spin projections and parities of 12 + and (14 + ) respectively. The shorter--lived isomer displays both normal and anomalous K-forbidden decays, which we show is the result of two-state mixing between the isomeric state and a member of a two-quasiparticle rotational band. The implied mixing matrix element of only 5 eV shows explicitly that very small mixing matrix elements may be responsible for anomalous K-hindered decays

  16. Time over threshold based multi-channel LuAG-APD PET detector

    International Nuclear Information System (INIS)

    Shimazoe, Kenji; Orita, Tadashi; Nakamura, Yasuaki; Takahashi, Hiroyuki

    2013-01-01

    To achieve efficient signal processing, several time-based positron emission tomography (PET) systems using a large number of granulated gamma-ray detectors have recently been proposed. In this work described here, a 144-channel Pr:LuAG avalanche photodiode (APD) PET detector that uses time over threshold (ToT) and pulse train methods was designed and fabricated. The detector is composed of 12×12 Pr:LuAG crystals, each of which produces a 2 mm×2 mm×10 mm pixel individually coupled to a 12×12 APD array, which in turn is connected pixel-by-pixel with one channel of a time over threshold based application-specific integrated circuit (ToT-ASIC) that was designed and fabricated using a 0.25 μm 3.3 V Taiwan Semiconductor Company complementary metal oxide semiconductor (TSMC CMOS) process. The ToT outputs are connected through a field-programmable gate array (FPGA) to a data acquisition (DAQ) system. Three front-end ASIC boards—each incorporating a ToT-ASIC chip, threshold control digital-to-analog converters (DACs), and connectors, and dissipating power at about 230 mW per board—are used to read from the 144-channel LuAG-APD detector. All three boards are connected through an FPGA board that is programmed to calibrate the individual thresholds of the ToT circuits to allow digital multiplexing to form an integrated PET module with a measured timing resolution of 4.2 ns. Images transmitted by this PET system can be successfully acquired through collimation masks. As a further implementation of this technology, an animal PET system consisting of eight gamma pixel modules forming a ring is planned

  17. Anomalies of magnetoresistance of compounds with atomic clusters RB12 (R = Ho, Er, Tm, Lu)

    International Nuclear Information System (INIS)

    Sluchanko, N. E.; Bogach, A. V.; Glushkov, V. V.; Demishev, S. V.; Samarin, N. A.; Sluchanko, D. N.; Dukhnenko, A. V.; Levchenko, A. V.

    2009-01-01

    The magnetoresistance and magnetization of single-crystal samples of rare-earth dodecaborides RB 12 (R = Ho, Er, Tm, Lu) have been measured at low temperatures (1.8-35 K) in a magnetic field of up to 70 kOe. The effect of positive magnetoresistance that obeys the Kohler's rule Δρ/ρ = f(ρ(0, 300 K)H/ρ(0, T)) is observed for the nonmagnetic metal LuB 12 . In the magnetic dodecaborides HoB 12 , ErB 12 , and TmB 12 , three characteristic regimes of the magnetoresistance behavior have been revealed: the positive magnetoresistance effect similar to the case of LuB 12 is observed at T > 25 K; in the range T N ≤ T ≤ 15 K, the magnetoresistance becomes negative and depends quadratically on the external magnetic field; and, finally, upon the transition to the antiferromagnetic phase (T N ), the positive magnetoresistance is again observed and its amplitude reaches 150% for HoB 12 . It has been shown that the observed anomalies of negative magnetoresistance in the paramagnetic phase can be explained within the Yosida model of conduction electron scattering by localized magnetic moments. The performed analysis confirms the formation of spin-polaron states in the 5d band in the vicinity of rare-earth ions in paramagnetic and magnetically ordered phases of RB 12 and makes it possible to reveal a number of specific features in the transformation of the magnetic structure of the compounds under investigation

  18. Indirect and direct measurement of thermal neutron acceleration by inelastic scattering on the 177Lu isomer

    International Nuclear Information System (INIS)

    Belier, G.; Roig, O.; Meot, V.; Daugas, J.M.; Aupiais, J.; Jutier, Ch.; Le Petit, G.; Veyssiere, Ch.

    2008-01-01

    When neutrons interact with isomers, these isomers can de-excite and in such a reaction the outgoing neutron has an energy greater than the in-going one. This process is referred as Inelastic Neutron Acceleration or Super-elastic Scattering. Up to now this process was observed for only two nucleus, 152m Eu and 180m Hf by measuring the number of fast neutrons produced by isomeric targets irradiated with thermal neutrons. In these experiments the energies of the accelerated neutrons were not measured. This report presents an indirect measurement of inelastic neutron acceleration on 177m Lu, based on the burn-up and the radiative capture cross sections measurements. Since at thermal energies the inelastic scattering and the radiative capture are the only processes that contribute to the isomer burn-up, the inelastic cross section can be deduced from the difference between the two measured quantities. Applying this method for the 177 Lu isomer with different neutron fluxes we obtained a value of (257 ± 50) barns (for a temperature of 323 K) and determined that there is no integral resonance for this process. In addition the radiative capture cross section on 177g Lu was measured with a much better accuracy than the accepted value. Since the acceleration cross section is quite high, a direct measurement of this process was undertaken, sending thermal neutrons and measuring the fast neutrons. The main goal now is to measure the outgoing neutron energies in order to identify the neutron transitions in the exit channel. In particular the K conservation question can be addressed by such a measurement. (author)

  19. DNA damage in blood lymphocytes in patients after {sup 177}Lu peptide receptor radionuclide therapy

    Energy Technology Data Exchange (ETDEWEB)

    Eberlein, Uta; Bluemel, Christina; Buck, Andreas Konrad; Werner, Rudolf Alexander; Lassmann, Michael [University of Wuerzburg, Department of Nuclear Medicine, Wuerzburg (Germany); Nowak, Carina; Scherthan, Harry [Bundeswehr Institute of Radiobiology affiliated to the University of Ulm, Munich (Germany)

    2015-10-15

    The aim of the study was to investigate DNA double strand break (DSB) formation and its correlation with the absorbed dose to the blood lymphocytes of patients undergoing their first peptide receptor radionuclide therapy (PRRT) with {sup 177}Lu-labelled DOTATATE/DOTATOC. The study group comprised 16 patients receiving their first PRRT. At least six peripheral blood samples were obtained before, and between 0.5 h and 48 h after radionuclide administration. From the time-activity curves of the blood and the whole body, residence times for blood self-irradiation and whole-body irradiation were determined. Peripheral blood lymphocytes were isolated, fixed with ethanol and subjected to immunofluorescence staining for colocalizing γ-H2AX/53BP1 DSB-marking foci. The average number of DSB foci per cell per patient sample was determined as a function of the absorbed dose to the blood and compared with an in vitro calibration curve established in our laboratory with {sup 131}I and {sup 177}Lu. The average number of radiation-induced foci (RIF) per cell increased over the first 5 h after radionuclide administration and decreased thereafter. A linear fit from 0 to 5 h as a function of the absorbed dose to the blood agreed with our in vitro calibration curve. At later time-points the number of RIF decreased, indicating progression of DNA repair. Measurements of RIF and the absorbed dose to the blood after systemic administration of {sup 177}Lu may be used to obtain data on the individual dose-response relationships in vivo. Individual patient data were characterized by a linear dose-dependent increase and an exponential decay function describing repair. (orig.)

  20. Developmental plasticity: Friend or foe?

    Science.gov (United States)

    Michels, Karin B

    2017-01-01

    Developmental plasticity - the concept that adaptation to changing and unfavorable environmental conditions are possible but may come at the price of compromised health potentials - has evolutionary grounding as it facilitates survival but dissents with fundamental evolutionary principles in that it may advance the lesser fit. It is an important cornerstone of the Developmental Origins of Health and Disease (DOHaD). Unlike evolutionary adaptation developmental plasticity may be short-lived and restricted to one or few generations and inheritance is uncertain. Potential mechanisms include epigenetic modifications adopted in utero which may not transmit to the next generation; future insights may allow adjustments of the outcomes of developmental plasticity.

  1. Radiation damage in plastic scintillators

    International Nuclear Information System (INIS)

    Majewski, S.

    1990-01-01

    Results of radiation damage studies in plastic scintillators are reviewed and critically analyzed from the point of view of applications of plastic scintillators in calorimetric detectors for the SSC. Damage to transmission and to fluorescent yield in different conditions is discussed. New directions in R ampersand D are outlined. Several examples are given of the most recent data on the new scintillating materials made with old and new plastics and fluors, which are exhibiting significantly improved radiation resistance. With a present rate of a vigorous R D programme, the survival limits in the vicinity of 100 MRad seem to be feasible within a couple of years

  2. Plastics recycling: challenges and opportunities

    OpenAIRE

    Hopewell, Jefferson; Dvorak, Robert; Kosior, Edward

    2009-01-01

    Plastics are inexpensive, lightweight and durable materials, which can readily be moulded into a variety of products that find use in a wide range of applications. As a consequence, the production of plastics has increased markedly over the last 60 years. However, current levels of their usage and disposal generate several environmental problems. Around 4 per cent of world oil and gas production, a non-renewable resource, is used as feedstock for plastics and a further 3–4% is expended to pro...

  3. Recycling of Reinforced Plastics

    Science.gov (United States)

    Adams, R. D.; Collins, Andrew; Cooper, Duncan; Wingfield-Digby, Mark; Watts-Farmer, Archibald; Laurence, Anna; Patel, Kayur; Stevens, Mark; Watkins, Rhodri

    2014-02-01

    This work has shown is that it is possible to recycle continuous and short fibre reinforced thermosetting resins while keeping almost the whole of the original material, both fibres and matrix, within the recyclate. By splitting, crushing hot or cold, and hot forming, it is possible to create a recyclable material, which we designate a Remat, which can then be used to remanufacture other shapes, examples of plates and tubes being demonstrated. Not only can remanufacturing be done, but it has been shown that over 50 % of the original mechanical properties, such as the E modulus, tensile strength, and interlaminar shear strength, can be retained. Four different forms of composite were investigated, a random mat Glass Fibre Reinforced Plastic (GFRP) bathroom component and boat hull, woven glass and carbon fibre cloth impregnated with an epoxy resin, and unidirectional carbon fibre pre-preg. One of the main factors found to affect composite recyclability was the type of resin matrix used in the composite. Thermoset resins tested were shown to have a temperature range around the Glass Transition Temperature (Tg) where they exhibit ductile behaviour, hence aiding reforming of the material. The high-grade carbon fibre prepreg was found to be less easy to recycle than the woven of random fibre laminates. One method of remanufacturing was by heating the Remat to above its glass transition temperature, bending it to shape, and then cooling it. However, unless precautions are taken, the geometric form may revert. This does not happen with the crushed material.

  4. Wood plastic combination

    International Nuclear Information System (INIS)

    Cunanan, S.A.; Bonoan, L.S.; Verceluz, F.P.; Azucena, E.A.

    1976-03-01

    The purpose of this study is to improve the physical and mechaniproperties of local inferior quality wood species by radiation-induced graft polymerization with plastic monomers. The process involves the following: 1) Preparation of sample; 2) Impregnation of sample with the monomers; 3) Irradiation of the impregnated sample with the use of 20,000 curie Co-60 as gamma-source; 4) Drying of irradiated sample to remove the unpolymerized monomer. Experimentation on different wood species were undertaken and the results given. From the results obtained, it can be concluded that the monomers systems MMA, MMA-USP, and styrene-USP are suitable for graft polymerization with the wood species almon, apitong, bagtikan, mayapis, red lauan, and tanguile. This is shown by their maximum conversion value which range from 86% to 96% with the optimum dose range of 1 to 2 Mrads. However, in the application of WPC process, properties that are required in a given wood product must be considered, thus aid in the selection of the monomer system to be used with a particular wood species. Some promising applications of WPC is in the manufacture of picker sticks, shuttles, and bobbins for the textile industry. However, there is a need for a pilot plant scale study so that an economic assessment of the commercial feasibility of this process can be made

  5. Helene: A Plastic Model

    Science.gov (United States)

    Umurhan, O. M.; Moore, J. M.; Howard, A. D.; Schenk, P.; White, O. L.

    2014-12-01

    Helene, the Saturnian L4 Trojan satellite co-orbiting Dionne and sitting within the E-ring, possesses an unusual morphology characteristic of broad km-scale basins and depressions and a generally smooth surface patterned with streaks and grooves which are indicative of non-typical mass transport. Elevation angles do not appear to exceed 10o at most. The nature and origin of the surface materials forming these grooved patterns is unknown. Given the low surface gravity (plastic-like flow like a Bingham fluid, we setup and test a number of likely scenarios to explain the observations. The numerical results qualitatively indicate that treating the mass-wasting materials as a Bingham material reproduces many of the qualitative features observed. We also find that in those simulations in which accretion is concomitant with Bingham mass-wasting, the long time-evolution of the surface flow shows intermittency in the total surface activity (defined as total surface integral of the absolute magnitude of the mass-flux). Detailed analyses identify the locations where this activity is most pronounced and we will discuss these and its implications in further detail.

  6. Targeted radionuclide therapy with A 177Lu-labeled anti-HER2 nanobody.

    Science.gov (United States)

    D'Huyvetter, Matthias; Vincke, Cécile; Xavier, Catarina; Aerts, An; Impens, Nathalie; Baatout, Sarah; De Raeve, Hendrik; Muyldermans, Serge; Caveliers, Vicky; Devoogdt, Nick; Lahoutte, Tony

    2014-01-01

    RIT has become an attractive strategy in cancer treatment, but still faces important drawbacks due to poor tumor penetration and undesirable pharmacokinetics of the targeting vehicles. Smaller radiolabeled antibody fragments and peptides feature highly specific target accumulation, resulting in low accumulation in healthy tissue, except for the kidneys. Nanobodies are the smallest (MWnanobodies is predominantly dictated by the number of polar residues in the C-terminal amino acid tag. Three nanobodies were produced with different C-terminal amino-acid tag sequences (Myc-His-tagged, His-tagged, and untagged). Dynamic planar imaging of Wistar rats with 111In-DTPA-nanobodies revealed that untagged nanobodies showed a 70% drop in kidney accumulation compared to Myc-His-tagged nanobodies at 50 min p.i.. In addition, coinfusion of untagged nanobodies with the plasma expander Gelofusin led to a final reduction of 90%. Similar findings were obtained with different 177Lu-DTPA-2Rs15d nanobody constructs in HER2pos tumor xenografted mice at 1 h p.i.. Kidney accumulation decreased 88% when comparing Myc-His-tagged to untagged 2Rs15d nanobody, and 95% with a coinfusion of Gelofusin, without affecting the tumor targeting capacity. Consequently, we identified a generic method to reduce kidney retention of radiolabeled nanobodies. Dosimetry calculations of Gelofusin-coinfused, untagged 177Lu-DTPA-2Rs15d revealed a dose of 0.90 Gy/MBq that was delivered to both tumor and kidneys and extremely low doses to healthy tissues. In a comparative study, 177Lu-DTPA-Trastuzumab supplied 6 times more radiation to the tumor than untagged 177Lu-DTPA-2Rs15d, but concomitantly also a 155, 34, 80, 26 and 4180 fold higher radioactivity burden to lung, liver, spleen, bone and blood. Most importantly, nanobody-based targeted radionuclide therapy in mice bearing small estiblashed HER2pos tumors led to an almost complete blockade of tumor growth and a significant difference in event-free survival

  7. Measurement of the half-life of sup 1 sup 7 sup 6 Lu

    CERN Document Server

    Nir-El, Y

    1998-01-01

    The half-life of sup 1 sup 7 sup 6 Lu was determined by measuring the disintegration rate of a solution of lutetium oxide, using a calibrated HPGe detector, and found to be (3.69+-0.02)x10 sup 1 sup 0 y. It is recommended that the current adopted value be calculated from the grouping of three published values since 1983, including our value, the weighted mean of which is (3.73+-0.01)x10 sup 1 sup 0 y.

  8. Thermal properties and continuous-wave laser performance of Yb:LuVO4 crystal

    Science.gov (United States)

    Cheng, Y.; Zhang, H. J.; Yu, Y. G.; Wang, J. Y.; Tao, X. T.; Liu, J. H.; Petrov, V.; Ling, Z. C.; Xia, H. R.; Jiang, M. H.

    2007-03-01

    A laser crystal of Yb:LuVO4 with high optical quality was grown by the Czochralski technique. Its thermal properties including specific heat, thermal expansion coefficients, and thermal conductivities along the a- and c-axis have been measured for the first time. Continuous-wave laser output up to 3.5 W at 1031 nm was obtained at room temperature through end-pumping by a high-power diode laser. The corresponding optical conversion efficiency was 43% and the slope efficiency was 72%.

  9. Multitasking the INS3D-LU code on the Cray Y-MP

    International Nuclear Information System (INIS)

    Fatoohi, Rod; Yoon, Seokkwan.

    1991-01-01

    This paper presents the results of multitasking the INS3D-LU code on eight processors. The code is a full Navier-Stokes solver for incompressible fluid in three dimensional generalized coordinates using a lower-upper symmetric-Gauss-Seidel implicit scheme. This code has been fully vectorized on oblique planes of sweep and parallelized using autotasking with some directives and minor modifications. The timing results for five grid sizes are presented and analyzed. The code has achieved a processing rate of over one Gflops

  10. Direct band gaps in multiferroic h-LuFeO3

    International Nuclear Information System (INIS)

    Holinsworth, B. S.; Mazumdar, D.; Musfeldt, J. L.; Brooks, C. M.; Mundy, J. A.; Das, H.; Fennie, C. J.; Cherian, J. G.; McGill, S. A.; Schlom, D. G.

    2015-01-01

    We measured the optical properties of epitaxial thin films of the metastable hexagonal polymorph of LuFeO 3 by absorption spectroscopy, magnetic circular dichroism, and photoconductivity. Comparison with complementary electronic structure calculations reveals a 1.1 eV direct gap involving hybridized Fe 3d z 2 +O 2p z →Fe d excitations at the Γ and A points, with a higher energy direct gap at 2.0 eV. Both charge gaps nicely overlap the solar spectrum

  11. Measurements of Coster-Kronig enhancement factors for Yb, Lu, Os and Pt elements

    International Nuclear Information System (INIS)

    Yilmaz, R.; Oz, E.; Tan, M.; Durak, R.; Demirel, A.I.; Sahin, Y.

    2009-01-01

    In this work X-ray production cross-sections' measurements, L ι , L α , L β and L γ , of Yb, Lu, Os and Pt elements have been studied at energies in the range 9.572-14.384 keV and the effect of Coster-Kronig transitions on fluorescence cross-sections for L X-ray line has been obtained. From these studies absolute values of L X-ray cross-sections have been calculated with incorporation of the enhancement due to the Coster-Kronig effect. The experimental enhancement factors tend to be smaller than those predicted by theory.

  12. Study of Y and Lu iron garnets using Bethe-Peierls-Weiss method

    Science.gov (United States)

    Goveas, Neena; Mukhopadhyay, G.; Mukhopadhyay, P.

    1994-11-01

    We study here the magnetic properties of Y- and Lu- Iron Garnets using the Bethe- Peierls-Weiss method modified to suit complex systems like these Garnets. We consider these Garnets as described by Heisenberg Hamiltonian with two sublattices (a,d) and determine the exchange interaction parameters Jad, Jaa and Jdd by matching the exerimental susceptibility curves. We find Jaa and Jdd to be much smaller than those determined by Néel theory, and consistent with those obtained by the study of spin wave spectra; the spin wave dispersion relation constant obtained using these parameters gives good agreement with the experimental values.

  13. D. Luís Pires : retalhos de vida de um prelado quatrocentista

    OpenAIRE

    Garrido, André

    2007-01-01

    D. Luís foi capelão em 1433, quando D. Duarte subiu ao trono, e era arcebispo de Braga quando morreu em 1480. Ao longo destes 43 anos foi embaixador régio, legado papal na Alemanha, bispo em três dioceses nacionais e responsável por um dos sínodos diocesanos mais importantes para o período medieval. No contexto nacional, foi testemunha directa dos momentos políticos que conduzirama Alfarrobeira. Já no âmbito europeu, foi um privilegiado espectador do despontar da arte e cultura renascentista ...

  14. The melt growth of large LuAP single crystals for PET scanners

    International Nuclear Information System (INIS)

    Petrosyan, Ashot; Ovanesyan, Karine; Shirinyan, Grigory; Butaeva, Tatyana; Derdzyan, Marina; Pedrini, Christian; Dujardin, Christophe; Garnier, Nicolas; Kamenskikh, Irina

    2005-01-01

    Performance properties of LuAP, a material of highly promising potential for future PET scanners, are presented, as they relate to crystal growth and composition. The light yield measured in 2x2x10 mm 3 elements with 0.4-0.5% Ce and cut from large size crystals (100 mm long and 15 mm in diameter) grown by the Bridgman technique is improved to 40% LSO. The ratio between light yield measured in vertical and horizontal arrangements in the best crystals is near 90%. The role of chemical purity in respect to divalent impurities is studied

  15. Electrically driven magnetic relaxation in multiferroic LuFe2O4

    International Nuclear Information System (INIS)

    Wang Fen; Li Changhui; Zou Tao; Liu Yi; Sun Young

    2010-01-01

    We report the electrical control of magnetization in multiferroic LuFe 2 O 4 by applying short current pulses. The magnitude of the induced magnetization change depends on the pulse width and current density. The voltage variation during the applied current pulses evidences an electric-field-induced breakdown of charge order and excludes the role of Joule heating. This current driven magnetization change can be interpreted with a three-temperature model in which the delocalized electrons accelerate spin relaxation through a strong spin-charge coupling inherent to multiferroicity. The electrically assisted magnetic relaxation provides a new approach for electrical control of magnetization.

  16. Multitasking the INS3D-LU code on the Cray Y-MP

    Science.gov (United States)

    Fatoohi, Rod; Yoon, Seokkwan

    1991-01-01

    This paper presents the results of multitasking the INS3D-LU code on eight processors. The code is a full Navier-Stokes solver for incompressible fluid in three dimensional generalized coordinates using a lower-upper symmetric-Gauss-Seidel implicit scheme. This code has been fully vectorized on oblique planes of sweep and parallelized using autotasking with some directives and minor modifications. The timing results for five grid sizes are presented and analyzed. The code has achieved a processing rate of over one Gflops.

  17. Multiferroic Properties of o-LuMnO3 Controlled by b-Axis Strain

    Science.gov (United States)

    Windsor, Y. W.; Huang, S. W.; Hu, Y.; Rettig, L.; Alberca, A.; Shimamoto, K.; Scagnoli, V.; Lippert, T.; Schneider, C. W.; Staub, U.

    2014-10-01

    Strain is a leading candidate for controlling magnetoelectric coupling in multiferroics. Here, we use x-ray diffraction to study the coupling between magnetic order and structural distortion in epitaxial films of the orthorhombic (o-) perovskite LuMnO3. An antiferromagnetic spin canting in the E-type magnetic structure is shown to be related to the ferroelectrically induced structural distortion and to a change in the magnetic propagation vector. By comparing films of different orientations and thicknesses, these quantities are found to be controlled by b-axis strain. It is shown that compressive strain destabilizes the commensurate E-type structure and reduces its accompanying ferroelectric distortion.

  18. Strain-Induced Ferromagnetism in Antiferromagnetic LuMnO3 Thin Films

    Science.gov (United States)

    White, J. S.; Bator, M.; Hu, Y.; Luetkens, H.; Stahn, J.; Capelli, S.; Das, S.; Döbeli, M.; Lippert, Th.; Malik, V. K.; Martynczuk, J.; Wokaun, A.; Kenzelmann, M.; Niedermayer, Ch.; Schneider, C. W.

    2013-07-01

    Single phase and strained LuMnO3 thin films are discovered to display coexisting ferromagnetic and antiferromagnetic orders. A large moment ferromagnetism (≈1μB), which is absent in bulk samples, is shown to display a magnetic moment distribution that is peaked at the highly strained substrate-film interface. We further show that the strain-induced ferromagnetism and the antiferromagnetic order are coupled via an exchange field, therefore demonstrating strained rare-earth manganite thin films as promising candidate systems for new multifunctional devices.

  19. Energy recovery from plastic wastes

    Energy Technology Data Exchange (ETDEWEB)

    Baur, A; Atzger, J

    1983-07-01

    The conversion of plastic wastes to energy is suggested as a practicable and advantageous alternative to recycling. A two-stage pilot gasification plant for the pyrolysis of wastes is described and the utilization of the resulting fuel gas discussed.

  20. Plasticity and creep of metals

    CERN Document Server

    Rusinko, Andrew

    2011-01-01

    Here is a systematic presentation of the postulates, theorems and principles of mathematical theories of plasticity and creep in metals, and their applications. Special attention is paid to analysis of the advantages and shortcomings of the classical theories.

  1. Neuromodulation, development and synaptic plasticity.

    Science.gov (United States)

    Foehring, R C; Lorenzon, N M

    1999-03-01

    We discuss parallels in the mechanisms underlying use-dependent synaptic plasticity during development and long-term potentiation (LTP) and long-term depression (LTD) in neocortical synapses. Neuromodulators, such as norepinephrine, serotonin, and acetylcholine have also been implicated in regulating both developmental plasticity and LTP/LTD. There are many potential levels of interaction between neuromodulators and plasticity. Ion channels are substrates for modulation in many cell types. We discuss examples of modulation of voltage-gated Ca2+ channels and Ca(2+)-dependent K+ channels and the consequences for neocortical pyramidal cell firing behaviour. At the time when developmental plasticity is most evident in rat cortex, the substrate for modulation is changing as the densities and relative proportions of various ion channels types are altered during ontogeny. We discuss examples of changes in K+ and Ca2+ channels and the consequence for modulation of neuronal activity.

  2. WEATHERABILITY OF ENHANCED DEGRADABLE PLASTICS

    Science.gov (United States)

    The main objective of this study was to assess the performance and the asociated variability of several selected enhanced degradable plastic materials under a variety of different exposure conditions. Other objectives were to identify the major products formed during degradation ...

  3. Dynamic Friction Parameter Identification Method with LuGre Model for Direct-Drive Rotary Torque Motor

    Directory of Open Access Journals (Sweden)

    Xingjian Wang

    2016-01-01

    Full Text Available Attainment of high-performance motion/velocity control objectives for the Direct-Drive Rotary (DDR torque motor should fully consider practical nonlinearities in controller design, such as dynamic friction. The LuGre model has been widely utilized to describe nonlinear friction behavior; however, parameter identification for the LuGre model remains a challenge. A new dynamic friction parameter identification method for LuGre model is proposed in this study. Static parameters are identified through a series of constant velocity experiments, while dynamic parameters are obtained through a presliding process. Novel evolutionary algorithm (NEA is utilized to increase identification accuracy. Experimental results gathered from the identification experiments conducted in the study for a practical DDR torque motor control system validate the effectiveness of the proposed method.

  4. Radiosynthesis and preclinical studies of 177Lu-labeled sulfadiazine. A possible theranostic agent for deep-seated bacterial infection

    International Nuclear Information System (INIS)

    Syed Ali Raza Naqvi; Rashid Rasheed; Muhammad Tauqeer Ahmed; Ameer Fawad Zahoor

    2017-01-01

    Sulfadiazine acts through inhibition of bacterial dihydropteroate synthetase. The radio-labeling of sulfadiazine with lutetium-177 ( 177 Lu) is expected to serve as a theranostic agent for deep-seated bacterial infections. The radiosynthesis of 177 Lu-sulfadiazine indicated a > 95% yield under optimized reaction conditions, and promising stability was found in blood serum. Biodistribution data in the absence of infection revealed minimal accumulation in key body organs. Kidneys were the main excretory organs, showed an uptake of 1.76 ± 0.09% ID/g organ at 6-h post-injection. Biodistribution, scintigraphic data, glomerular filtration rate, and cytotoxicity results encourage clinical investigation of 177 Lu-sulfadiazine as a novel theranostic agent for deep-seated bacterial infection. (author)

  5. Synthesis, Tunable Multicolor Output, and High Pure Red Upconversion Emission of Lanthanide-Doped Lu2O3 Nanosheets

    Directory of Open Access Journals (Sweden)

    Lingzhen Yin

    2013-01-01

    Full Text Available Yb3+ and Ln3+ (Ln = Er, Ho codoped Lu2O3 square nanocubic sheets were successfully synthesized via a facile hydrothermal method followed by a subsequent dehydration process. The crystal phase, morphology, and composition of hydroxide precursors and target oxides were characterized by X-ray diffraction (XRD, field emission scanning electron microscope (FE-SEM, and energy-dispersive X-ray spectroscope (EDS. Results present the as-prepared Lu2O3 crystallized in cubic phase, and the monodispersed square nanosheets were maintained both in hydroxide and oxides. Moreover, under 980 nm laser diode (LD excitation, multicolor output from red to yellow was realized by codoped different lanthanide ions in Lu2O3. It is noteworthy that high pure strong red upconversion emission with red to green ratio of 443.3 of Er-containing nanocrystals was obtained, which is beneficial for in vivo optical bioimaging.

  6. Surprising luminescent properties of the polyphosphates Ln(PO3)3:Eu (Ln = Y, Gd, Lu).

    Science.gov (United States)

    Höppe, Henning A; Kazmierczak, Karolina; Kacprzak, Sylwia; Schellenberg, Inga; Pöttgen, Rainer

    2011-10-21

    The optical emission properties of the lanthanoid catena-polyphosphates Ln(PO(3))(3) (Ln = Y, Gd, Lu) doped with europium were investigated. Incommensurately modulated β-Y(PO(3))(3):Eu (super space group Cc (0|0.364|0)0) and Gd(PO(3))(3):Eu (space group I2/a) show the usual emission characteristics of Eu(3+), while in Lu(PO(3))(3):Eu (space group Cc) the europium is unprecedentedly partially reduced to the divalent state, as proven by both a broad emission band at 406 nm excited at 279 nm and an EPR spectroscopic investigation. (151)Eu-Mössbauer spectroscopy showed that only a very small part of the europium is reduced in Lu(PO(3))(3):Eu. An explanation for this unusual behaviour is given. This journal is © The Royal Society of Chemistry 2011

  7. Development and biological studies of ¹⁷⁷Lu-DOTA-rituximab for the treatment of Non-Hodgkin's lymphoma.

    Science.gov (United States)

    Massicano, Adriana V F; Pujatti, Priscilla B; Alcarde, Lais F; Suzuki, Miriam F; Spencer, Patrick J; Araújo, Elaine B

    2016-01-01

    The optimization of DOTA-NHS-ester conjugation to Rituximab using different Ab:DOTA molar ratios (1:10, 1:20, 1:50 and 1:100) was studied. High radiochemical yield, in vitro stability and immunoreactive fraction were obtained for the Rituximab conjugated at 1:50 molar ratio, resulting in the incorporation of an average number of 4.9 ± 1.1 DOTA per Rituximab molecule. Labeling with 177Lu was performed in high specific activity with great in vitro stability. Biodistribution in healthy and xenographed mice showed tumor uptake and high in vivo stability as evidenced by low uptake in bone. The properties of 177Lu-DOTA-Rituximab prepared from DOTA-NHS-ester suggest the potential for the application of the 177Lu-labeled antibody in preliminary clinical studies.

  8. Crystal growth and scintillation properties of Er-doped Lu3Al5O12 single crystals

    International Nuclear Information System (INIS)

    Sugiyama, Makoto; Fujimoto, Yutaka; Yanagida, Takayuki; Totsuka, Daisuke; Kurosawa, Shunsuke; Futami, Yoshisuke; Yokota, Yuui; Chani, Valery; Yoshikawa, Akira

    2012-01-01

    Er-doped Lu 3 Al 5 O 12 (Er:LuAG) single crystalline scintillators with different Er concentrations of 0.1, 0.5, 1, and 3% were grown by the micro-pulling-down (μ-PD) method. The grown crystals were composed of single-phase material, as demonstrated by powder X-ray diffraction (XRD). The radioluminescence spectra measured under 241 Am α-ray excitation indicated host emission at approximately 350 nm and Er 3+ 4f-4f emissions. According to the pulse height spectra recorded under γ-ray irradiation, the 0.5% Er:LuAG exhibited the highest peak channel among the samples. The γ-ray excited decay time profiles were well fitted by the two-component exponential approximation (0.8 μs and 6-10 μs).

  9. Computational materials science: Nanoscale plasticity

    DEFF Research Database (Denmark)

    Jacobsen, Karsten Wedel; Schiøtz, Jakob

    2002-01-01

    How does plastic deformation of polycrystalline materials with grain sizes less than 100 nm look at the atomic scale? A large-scale molecular dynamics simulation of nanocrystalline alluminium reveals some surprising behaviour.......How does plastic deformation of polycrystalline materials with grain sizes less than 100 nm look at the atomic scale? A large-scale molecular dynamics simulation of nanocrystalline alluminium reveals some surprising behaviour....

  10. Biocide Usage in Plastic Products

    OpenAIRE

    Kavak, Nergizhan; Çakır, Ayşegül; Koltuk, Fatmagül; Uzun, Utku

    2015-01-01

    People’s demand of improving their life quality caused to the term of hygiene become popular and increased the tendency to use more reliable and healthy products. This tendency makes the continuous developments in the properties of the materials used in manufactured goods compulsory. It is possible to create anti-bacterial plastic products by adding biocidal additives to plastic materials which have a wide-range of application in the areas such as health (medicine), food and many other indust...

  11. Interhemispheric plasticity in humans.

    Science.gov (United States)

    Hortobágyi, Tibor; Richardson, Sarah Pirio; Lomarev, Mikhael; Shamim, Ejaz; Meunier, Sabine; Russman, Heike; Dang, Nguyet; Hallett, Mark

    2011-07-01

    Chronic unimanual motor practice increases the motor output not only in the trained but also in the nonexercised homologous muscle in the opposite limb. We examined the hypothesis that adaptations in motor cortical excitability of the nontrained primary motor cortex (iM1) and in interhemispheric inhibition from the trained to the nontrained M1 mediate this interlimb cross education. Healthy, young volunteers (n=12) performed 1000 submaximal voluntary contractions (MVC) of the right first dorsal interosseus (FDI) at 80% MVC during 20 sessions. Trained FDI's MVC increased 49.9%, and the untrained FDI's MVC increased 28.1%. Although corticospinal excitability in iM1, measured with transcranial magnetic stimulation (TMS) before and after every fifth session, increased 6% at rest, these changes, as those in intracortical inhibition and facilitation, did not correlate with cross education. When weak and strong TMS of iM1 were delivered on a background of a weak and strong muscle contraction, respectively, of the right FDI, excitability of iM1 increased dramatically after 20 sessions. Interhemispheric inhibition decreased 8.9% acutely within sessions and 30.9% chronically during 20 sessions and these chronic reductions progressively became more strongly associated with cross education. There were no changes in force or TMS measures in the trained group's left abductor minimi digiti and there were no changes in the nonexercising control group (n=8). The findings provide the first evidence for plasticity of interhemispheric connections to mediate cross education produced by a simple motor task.

  12. Amifostine protects rat kidneys during peptide receptor radionuclide therapy with [177Lu-DOTA0,Tyr3]octreotate

    International Nuclear Information System (INIS)

    Rolleman, Edgar J.; Forrer, Flavio; Bernard, Bert; Bijster, Magda; Valkema, Roelf; Krenning, Eric P.; Jong, Marion de; Vermeij, Marcel

    2007-01-01

    In peptide receptor radionuclide therapy (PRRT) using radiolabelled somatostatin analogues, the kidneys are the major dose-limiting organs, because of tubular reabsorption and retention of radioactivity. Preventing renal uptake or toxicity will allow for higher tumour radiation doses. We tested the cytoprotective drug amifostine, which selectively protects healthy tissue during chemo- and radiotherapy, for its renoprotective capacities after PRRT with high-dose [ 177 Lu-DOTA 0 ,Tyr 3 ]octreotate. Male Lewis rats were injected with 278 or 555 MBq [ 177 Lu-DOTA 0 ,Tyr 3 ]octreotate to create renal damage and were followed up for 130 days. For renoprotection, rats received either amifostine or co-injection with lysine. Kidneys, blood and urine were collected for toxicity measurements. At 130 days after PRRT, a single-photon emission computed tomography (SPECT) scan was performed to quantify tubular uptake of 99m Tc-dimercaptosuccinic acid (DMSA), a measure of tubular function. Treatment with 555 MBq [ 177 Lu-DOTA 0 ,Tyr 3 ]octreotate resulted in body weight loss, elevated creatinine and proteinuria. Amifostine and lysine treatment significantly prevented this rise in creatinine and the level of proteinuria, but did not improve the histological damage. In contrast, after 278 MBq [ 177 Lu-DOTA 0 ,Tyr 3 ]octreotate, creatinine values were slightly, but not significantly, elevated compared with the control rats. Proteinuria and histological damage were different from controls and were significantly improved by amifostine treatment. Quantification of 99m Tc-DMSA SPECT scintigrams at 130 days after [ 177 Lu-DOTA 0 ,Tyr 3 ]octreotate therapy correlated well with 1/creatinine (r 2 = 0.772, p 177 Lu-DOTA 0 ,Tyr 3 ]octreotate. Besides lysine, amifostine might be used in clinical PRRT as well as to maximise anti-tumour efficacy. (orig.)

  13. Luminescence properties and energy transfer investigations of Sr_3Lu(PO_4)_3:Ce"3"+, Tb"3"+ phosphors

    International Nuclear Information System (INIS)

    Yang, Zaifa; Xu, Denghui; Sun, Jiayue; Du, Jiangnan; Gao, Xuedong

    2016-01-01

    Highlights: • A phosphor Sr_3Lu(PO_4)_3:Ce"3"+, Tb"3"+ for UV-based white LEDs was firstly synthesized successfully. • The phase structure and photoluminescence properties of samples were studied in detail. • The energy transfer process from Ce"3"+ to Tb"3"+ ions was illustrated in detail. • Sr_3Lu(PO_4)_3:Ce"3"+, Tb"3"+ phosphor has potential applications as an UV-convertible phosphor for white light emitting diodes. - Abstract: A series of Ce"3"+ or Tb"3"+ doped and Ce"3"+/Tb"3"+ co-doped Sr_3Lu(PO_4)_3 phosphors were prepared via the conventional high temperature solid-state reaction. The phase structure, photoluminescence and energy transfer properties of samples were studied in detail. The optimal proportion of Ce"3"+ single doping is 4 mol% with maximal fluorescence intensity. The Sr_3Lu(PO_4)_3:Ce"3"+, Tb"3"+ phosphor shows both a blue emission (428 nm) from Ce"3"+ and a yellowish-green emission (545 nm) from Tb"3"+ with considerable intensity under ultraviolet (UV) excitation (268 nm). The energy transfer from Ce"3"+ to Tb"3"+ ions takes place in the Sr_3Lu(PO_4)_3:Ce"3"+, Tb"3"+ phosphor on the basis of the analysis of the luminescence spectra. The energy transfer mechanism from Ce"3"+ to Tb"3"+ ions was proved to be dipole–dipole interaction. The energy transfer behaviors in Sr_3Lu(PO_4)_3:Ce"3"+, Tb"3"+ phosphor is also investigated by the lifetime measurement. The results show that this phosphor has potential applications for UV white-light LEDs.

  14. 177 Lu-Dota-octreotate radionuclide therapy of advanced gastrointestinal neuroendocrine tumors: results from a phase II study

    Energy Technology Data Exchange (ETDEWEB)

    Paganelli, Giovanni; Sansovini, Maddalena; Ambrosetti, Alice; Severi, Stefano; Ianniello, Annarita; Matteucci, Federica [Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Nuclear Medicine and Radiometabolic Units, Meldola, FC (Italy); Monti, Manuela; Scarpi, Emanuela [IRST IRCCS, Unit of Biostatistics and Clinical Trials, Meldola (Italy); Donati, Caterina [IRST IRCCS, Oncology Pharmacy Laboratory, Meldola (Italy); Amadori, Dino [IRST IRCCS, Department of Medical Oncology, Meldola (Italy)

    2014-10-15

    We evaluated the activity and safety profile of {sup 177}Lu-Dotatate peptide receptor radionuclide therapy (Lu-PRRT) in patients with advanced, well-differentiated (G1-G2) gastrointestinal neuroendocrine tumors (GI-NETs). Forty-three patients with radiological tumor progression at baseline and a positive Octreoscan registered completed the treatment with Lu-PRRT, resulting in the cumulative activity of 18.5 or 27.8 GBq in five cycles. Total activity was scheduled on the basis of kidney function or bone marrow reserve. Twenty-five (58 %) patients were treated with a ''standard'' Lu-PRRT full dosage (FD) of 25.7 GBq (range 22.2-27.8), while the remaining 18 patients (42 %) who, at enrolment, showed a higher probability of developing kidney or bone marrow toxicity received a reduced dosage (RD) of 18.4 GBq (range 14.4-20.4). According to SWOG criteria, the overall response was complete response (CR) in (7 %) cases and stable disease (SD) in 33 (77 %), with a disease control rate (DCR) of 84 %. Median response duration was 25 months (range 7-50). Median progression-free survival (PFS) was 36 months (95 % CI 24-nr), and median overall survival (OS) has not yet been reached. Remarkably, none of the patients, including those at a higher risk of toxicity, showed side-effects after either dosage of Lu-PRRT. Lu-PRRT was shown to be an effective therapeutic option in our patients with advanced progressive GI-NETs, showing an 84 % DCR (95 % CI 73-95) that lasted for 25 months and a PFS of 36 months. Both activities of 27.8 GBq and 18.5 GBq proved safe and effective in all patients, including those with a higher probability of developing kidney or bone marrow toxicity. (orig.)

  15. Influence of Eu{sup 3+} doping content on antioxidant properties of Lu{sub 2}O{sub 3} sol-gel derived nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Olvera Salazar, Arturo [Universidad Del Valle de México Campus Lomas Verde, Paseo de las Aves No.1 Col. San Mateo Nopala. Naucalpan de Juárez, Edo. Méx. C.P. 53220 (Mexico); García Hernández, Margarita, E-mail: margarita.garcia@itcm.edu.mx [Tecnológico Nacional de México-Instituto Tecnológico de Ciudad Madero. Av. 1o. de Mayo esq. Sor Juana Inés de la Cruz s/n Col. Los Mangos Cd. Madero Tamaulipas C.P.89440 (Mexico); López Camacho, Perla Yolanda [Universidad Autónoma Metropolitana, Unidad Cuajimalpa. Av. Vasco de Quiroga 4871, Col. Santa Fé Cuajimalpa, Cuajimalpa D.F. C.P. 05348 (Mexico); López Marure, Arturo [Instituto Politécnico Nacional, CICATA Altamira. Carretera Tampico-Puerto Industrial Altamira, Altamira, Tamaulipas C.P. 89600 (Mexico); Reyes de la Torre, Adriana Isabel [Tecnológico Nacional de México-Instituto Tecnológico de Ciudad Madero. Av. 1o. de Mayo esq. Sor Juana Inés de la Cruz s/n Col. Los Mangos Cd. Madero Tamaulipas C.P.89440 (Mexico); Morales Ramírez, Ángel de Jesús [Instituto Politécnico Nacional, CIITEC Azcapotzalco. Cerrada de Cecati S/N, Col. Santa Catarina, Azcapotzalco, D.F. C.P. 02250 (Mexico); and others

    2016-12-01

    This paper presents the synthesis of pure and europium-doped lutetium oxide (Lu{sub 2}O{sub 3}) powders prepared by sol-gel method. The influence of europium ion concentration into Lu{sub 2}O{sub 3} nanocrystallites was investigated for first time in an in vitro system using a modified ABTS radical cation decolorization assay to determine the antioxidant activity. The crystalline structure of Lu{sub 2}O{sub 3} and Eu:Lu{sub 2}O{sub 3} powders was elucidated by XRD obtaining cubic phase in all system without secondary products in accordance with FT-IR results. By TEM and Scherrer equation, it was determined that Lu{sub 2}O{sub 3} and Eu:Lu{sub 2}O{sub 3} powders presented nearly spherical particle morphology with crystallites sizes in the range of 8 to 13 nm. The antioxidant assays results revealed that europium ion enhance Lu{sub 2}O{sub 3} powders antioxidant properties, showing that 12.5 mol% of europium is sufficient to reach its maximum capacity. - Highlights: • For first time the effect of the Eu content vs antioxidant properties was studied. • Sol-gel particles of Lu{sub 2}O{sub 3}:Eu{sup 3+} nanopowders showed relevant antioxidant properties. • The antioxidant behavior remains stable at higher Eu levels.

  16. Luminescence and Energy Transfer in Lu3Al5O12 Scintillators Co-Doped with Ce3+ and Tb3+

    NARCIS (Netherlands)

    Ogiegło, J.M.; Zych, A.K.; Ivanovskikh, K.; Jüstel, T.; Ronda, R.C.; Meijerink, A.

    2012-01-01

    Lu3Al5O12 (LuAG) doped with Ce3+ is a promising scintillator material with a high density and a fast response time. The light output under X-ray or γ-ray excitation is, however, well below the theoretical limit. In this paper the influence of codoping with Tb3+ is investigated with the aim to

  17. Luminescence and energy transfer in Lu3Al5O12 scintillators co-doped with Ce3+ and Pr3+

    NARCIS (Netherlands)

    Ogiegło, J.M.; Zych, A.K.; Jüstel, T.; Meijerink, A.; Ronda, R.C.

    2013-01-01

    Lu3Al5O12:Ce3+ (LuAG:Ce) is a scintillator with a fast response time. The light yield is lower than theoretically expected and to increase the light yield co-doping with Pr3+ is investigated. To better understand the energy flow to the Ce3+ ion, first low temperature emission and excitation spectra

  18. Radioimmunotherapy (RIT) Dose-Escalation Studies in Prostate Cancer Using Anti-PSMA Antibody 177Lu-J591: RIT Alone and RIT in Combination with Docetaxel

    National Research Council Canada - National Science Library

    Vallabhajosula, Shankar

    2007-01-01

    Phase I dose escalation studies with 177Lu-DOTA-huJ591 using dose fractionation regimen will be performed in patients with PCa and who have recurrent and/or metastatic disease. The 177Lu dose (20-45 mCi/m2...

  19. Radioimmunotherapy (RIT) Dose-Escalation Studies in Prostate Cancer Using Anti-PSMA Antibody 177Lu-J591: RIT Alone and RIT in Combination With Docetaxel

    National Research Council Canada - National Science Library

    Vallabhajosula, Shankar

    2006-01-01

    Phase I dose escalation studies with 177Lu-DOTA-huJ591 using dose fractionation regimen will be performed in patients with PCa and who have recurrent and/or metastatic disease. The 177Lu dose (20-45 mCi/m2...

  20. A Half-Life Measurement of the 343.4 keV Level in {sup 175}Lu

    Energy Technology Data Exchange (ETDEWEB)

    Hoejeberg, M; Malmskog, S G

    1969-05-15

    Great theoretical interest has recently been shown in the asymptotically forbidden 5/2 5/2+ [402] - 7/2 7/2+ [404] M1-transitions in {sup 181}Ta and {sup 175}Lu . Half-lives of the 5/2 5/2+ [402] level in {sup 175}Lu have been reported which differ by more than a factor of 10. Using an electron-electron coincidence spectrometer the half-life of this level has been re-measured and a value of (0.26 {+-} 0.02) nsec has been established.

  1. Preparation and in vitro evaluation of 177Lu-iPSMA-RGD as a new heterobivalent radiopharmaceutical

    International Nuclear Information System (INIS)

    Escudero-Castellanos, Alondra; Universidad Autonoma del Estado de Mexico, Toluca, Estado de Mexico; Ocampo-Garcia, B.E.; Ferro-Flores, Guillermina; Santos-Cuevas, C.L.; Isaac-Olive, Keila; Olmos-Ortiz, Andrea; Garcia-Quiroz, Janice; Garcia-Becerra, Rocio; Diaz, Lorenza

    2017-01-01

    This study aimed to synthesize a new 177 Lu-iPSMA-RGD heterobivalent radiopharmaceutical, as well as to assess the in vitro radiopharmaceutical potential to target cancer cells overexpressing PSMA and α(v) β(3) integrins. The radiotracer prepared with a radiochemical purity of 98.8 ± 1.0% showed stability in human serum, specific recognition with suitable affinity to PSMA and α(v)β(3) integrins, and capability to inhibit cancer cell proliferation and VEGF signaling (antiangiogenic effect). Results warrant further preclinical studies to establish the 177 Lu-iPSMA-RGD potential as a dual therapeutic radiopharmaceutical. (author)

  2. Multispecies animal investigation on biodistribution, pharmacokinetics and toxicity of 177Lu-EDTMP, a potential bone pain palliation agent

    International Nuclear Information System (INIS)

    Mathe, Domokos; Balogh, Lajos; Polyak, Andras; Kiraly, Reka; Marian, Terez; Pawlak, Dariusz; Zaknun, John J.; Pillai, Maroor R.A.; Janoki, Gyozo A.

    2010-01-01

    Introduction: Radionuclide therapy (RNT) is an effective method for bone pain palliation in patients suffering from bone metastasis. Due to the long half-life, easy production and relatively low β- energy, 177 Lu [T 1/2 =6.73 days, E βmax =497 keV, E γ =113 keV (6.4%), 208 keV (11%)]-based radiopharmaceuticals offer logistical advantage for wider use. This paper reports the results of a multispecies biodistribution and toxicity studies of 177 Lu-EDTMP to collect preclinical data for starting human clinical trials. Methods: 177 Lu-EDTMP with radiochemical purity greater than 99% was formulated by using a lyophilized kit of EDTMP (35 mg of EDTMP, 5.72 g of CaO and 14.1 mg of NaOH). Biodistribution studies were conducted in mice and rabbits. Small animal imaging was performed using NanoSPECT/CT (Mediso, Ltd., Hungary) and digital autoradiography. Gamma camera imaging was done in rabbits and dogs. Four levels of activity (9.25 through 37 MBq/kg body weight) of 177 Lu-EDTMP were injected in four groups of three dogs each to study the toxicological effects. Results: 177 Lu-EDTMP accumulated almost exclusively in the skeletal system (peak ca. 41% of the injected activity in bone with terminal elimination half-life of 2130 and 1870 h in mice and rabbits, respectively) with a peak uptake during 1-3 h. Excretion of the radiopharmaceutical was through the urinary system. Imaging studies showed that all species (mouse, rat, rabbit and dog) take up the compound in regions of remodeling bone, while kidney retention is not visible after 1 day postinjection (pi). In dogs, the highest applied activity (37 MBq/kg body weight) led to a moderate decrease in platelet concentration (mean, 160 g/L) at 1 week pi with no toxicity. Conclusion: The protracted effective half-life of 177 Lu-EDTMP in bone supports that modifying the EDTMP molecule by introducing 177 Lu does not alter its biological behaviour as a specific bone-seeking tracer. Species-specific pharmacokinetic behavior

  3. Multispecies animal investigation on biodistribution, pharmacokinetics and toxicity of {sup 177}Lu-EDTMP, a potential bone pain palliation agent

    Energy Technology Data Exchange (ETDEWEB)

    Mathe, Domokos [Department of Applied Radioisotopes and Animal Experimentation, National ' Frederic Joliot-Curie' Institute of Radiobiology and Radiohygiene, H-1221 Budapest (Hungary)], E-mail: mdomokos@hp.osski.hu; Balogh, Lajos; Polyak, Andras; Kiraly, Reka [Department of Applied Radioisotopes and Animal Experimentation, National ' Frederic Joliot-Curie' Institute of Radiobiology and Radiohygiene, H-1221 Budapest (Hungary); Marian, Terez [Institute of Nuclear Medicine, Debrecen University, Debrecen (Hungary); Pawlak, Dariusz [Institute of Atomic Energy, Radioisotope Centre POLATOM, Swierk-Otwock (Poland); Zaknun, John J.; Pillai, Maroor R.A. [International Atomic Energy Agency (IAEA), Vienna (Austria); Janoki, Gyozo A. [Department of Applied Radioisotopes and Animal Experimentation, National ' Frederic Joliot-Curie' Institute of Radiobiology and Radiohygiene, H-1221 Budapest (Hungary)

    2010-02-15

    Introduction: Radionuclide therapy (RNT) is an effective method for bone pain palliation in patients suffering from bone metastasis. Due to the long half-life, easy production and relatively low {beta}- energy, {sup 177}Lu [T{sub 1/2}=6.73 days, E{sub {beta}}{sub max}=497 keV, E{sub {gamma}}=113 keV (6.4%), 208 keV (11%)]-based radiopharmaceuticals offer logistical advantage for wider use. This paper reports the results of a multispecies biodistribution and toxicity studies of {sup 177}Lu-EDTMP to collect preclinical data for starting human clinical trials. Methods: {sup 177}Lu-EDTMP with radiochemical purity greater than 99% was formulated by using a lyophilized kit of EDTMP (35 mg of EDTMP, 5.72 g of CaO and 14.1 mg of NaOH). Biodistribution studies were conducted in mice and rabbits. Small animal imaging was performed using NanoSPECT/CT (Mediso, Ltd., Hungary) and digital autoradiography. Gamma camera imaging was done in rabbits and dogs. Four levels of activity (9.25 through 37 MBq/kg body weight) of {sup 177}Lu-EDTMP were injected in four groups of three dogs each to study the toxicological effects. Results: {sup 177}Lu-EDTMP accumulated almost exclusively in the skeletal system (peak ca. 41% of the injected activity in bone with terminal elimination half-life of 2130 and 1870 h in mice and rabbits, respectively) with a peak uptake during 1-3 h. Excretion of the radiopharmaceutical was through the urinary system. Imaging studies showed that all species (mouse, rat, rabbit and dog) take up the compound in regions of remodeling bone, while kidney retention is not visible after 1 day postinjection (pi). In dogs, the highest applied activity (37 MBq/kg body weight) led to a moderate decrease in platelet concentration (mean, 160 g/L) at 1 week pi with no toxicity. Conclusion: The protracted effective half-life of {sup 177}Lu-EDTMP in bone supports that modifying the EDTMP molecule by introducing {sup 177}Lu does not alter its biological behaviour as a specific bone

  4. New anisotropic rare earth fluorides BaR2F8(R=Y,Dy-Lu): growth and characterization

    International Nuclear Information System (INIS)

    Kaminskii, A.A.; Butashin, A.V.; Sulyanov, S.N.; Bagayev, S.N.; Eichler, H.J.; Findeisen, J.; Liu, B.; Taeuber, U.; Peuser, P.

    1998-01-01

    Polymorphism of BaR 2 F 8 compounds is analyzed, and some peculiarities of the crystal growth from the melt are discussed. We report on the orthorhombic BaLu 2 F 8 crystal with ordered structure, a new crystalline material for generating Ln 3+ activator ions. Spectroscopic and laser characteristics of Nd 3+ - and Er 3+ -doped BaLu 2 F 8 samples are discussed as representative examples. Besides, we pay special attention to monoclinic BaY 2 F 8 :Er 3+ crystals, as active media for highly efficient CW 3 μm laser-diode pumped lasers. (orig.)

  5. Zīmola LU BVEF koncepta izveide un novērtējums.

    OpenAIRE

    Svilāne, Zane

    2017-01-01

    Maģistra darba tēma ir “Zīmola LU BVEF koncepta izveide un novērtējums”. Maģistra darba mērķis ir pamatojoties uz mērķa tirgus analīze no patērētāju perspektīvas, identificēt nozīmīgākās fakultātes zīmola pārpozicionēšanas un mārketinga stratēģijas problēmas, kā arī izstrādāt priekšlikumus tās pilnveidošanai. Darba pirmajā daļā, autore pēta zīmola būtību un īpatnības, kā arī zīmolvedības stratēģijas un veiksmīga zīmola priekšnosacījumus. Darba otrajā nodaļā, autore pēta zīmola LU BVEF veidoša...

  6. Advancing Control for Shield Tunneling Machine by Backstepping Design with LuGre Friction Model

    Directory of Open Access Journals (Sweden)

    Haibo Xie

    2014-01-01

    Full Text Available Shield tunneling machine is widely applied for underground tunnel construction. The shield machine is a complex machine with large momentum and ultralow advancing speed. The working condition underground is rather complicated and unpredictable, and brings big trouble in controlling the advancing speed. This paper focused on the advancing motion control on desired tunnel axis. A three-state dynamic model was established with considering unknown front face earth pressure force and unknown friction force. LuGre friction model was introduced to describe the friction force. Backstepping design was then proposed to make tracking error converge to zero. To have a comparison study, controller without LuGre model was designed. Tracking simulations of speed regulations and simulations when front face earth pressure changed were carried out to show the transient performances of the proposed controller. The results indicated that the controller had good tracking performance even under changing geological conditions. Experiments of speed regulations were carried out to have validations of the controllers.

  7. Stellar Neutron Capture Cross Sections of the Lu and Hf Isotopes

    International Nuclear Information System (INIS)

    Wisshak, K.; Voss, F.; Kaeppeler, F.; Kazakov, L.; Krticka, M.

    2005-01-01

    The neutron capture cross sections of 175,176Lu and 176,177,178,179,180Hf have been measured in the energy range from 3 to 225 keV at the Karlsruhe 3.7 MV Van de Graaff accelerator relative to the gold standard. Neutrons were produced by the 7Li(p,n)7Be reaction and capture events were detected by the Karlsruhe 4πBaF2 detector. The cross section ratios could be determined with uncertainties between 0.9 and 1.8% about a factor of five more accurate than previous data. A strong population of isomeric states was found in neutron capture of the Hf isotopes, which are only partially explained by CASINO/GEANT simulations based on the known level schemes.Maxwellian averaged neutron capture cross sections were calculated for thermal energies between kT = 8 keV and 100 keV. Severe differences up to40% were found to the data of a recent evaluation based on existing experimental results. The new data allow for a much more reliable analysis of the important branching in the s-process synthesis path at 176Lu which can be interpreted as an s-process thermometer

  8. Sparse Localization with a Mobile Beacon Based on LU Decomposition in Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Chunhui Zhao

    2015-09-01

    Full Text Available Node localization is the core in wireless sensor network. It can be solved by powerful beacons, which are equipped with global positioning system devices to know their location information. In this article, we present a novel sparse localization approach with a mobile beacon based on LU decomposition. Our scheme firstly translates node localization problem into a 1-sparse vector recovery problem by establishing sparse localization model. Then, LU decomposition pre-processing is adopted to solve the problem that measurement matrix does not meet the re¬stricted isometry property. Later, the 1-sparse vector can be exactly recovered by compressive sensing. Finally, as the 1-sparse vector is approximate sparse, weighted Cen¬troid scheme is introduced to accurately locate the node. Simulation and analysis show that our scheme has better localization performance and lower requirement for the mobile beacon than MAP+GC, MAP-M, and MAP-MN schemes. In addition, the obstacles and DOI have little effect on the novel scheme, and it has great localization performance under low SNR, thus, the scheme proposed is robust.

  9. Transparent Lu 2 O 3 :Eu ceramics by sinter and HIP optimization

    Science.gov (United States)

    Seeley, Z. M.; Kuntz, J. D.; Cherepy, N. J.; Payne, S. A.

    2011-09-01

    Evolution of porosity and microstructure was observed during densification of lutetium oxide ceramics doped with europium (Lu 2O 3:Eu) fabricated via vacuum sintering and hot isostatic pressing (HIP'ing). Nano-scale starting powder was uniaxially pressed and sintered under high vacuum at temperatures between 1575 and 1850 °C to obtain densities ranging between 94% and 99%, respectively. Sintered compacts were then subjected to 200 MPa argon gas at 1850 °C to reach full density. Vacuum sintering above 1650 °C led to rapid grain growth prior to densification, rendering the pores immobile. Sintering between 1600 and 1650 °C resulted in closed porosity yet a fine grain size to allow the pores to remain mobile during the subsequent HIP'ing step, resulting in a fully-dense highly transparent ceramic without the need for subsequent air anneal. Light yield performance was measured and Lu 2O 3:Eu showed ˜4 times higher light yield than commercially used scintillating glass indicating that this material has the potential to improve the performance of high energy radiography devices.

  10. Microstructure and deuterium retention after ion irradiation of W–Lu2O3 composites

    International Nuclear Information System (INIS)

    Lin, Jin–Shan; Luo, Lai–Ma; Xu, Qiu; Zan, Xiang; Zhu, Xiao–Yong; Wu, Yu–Cheng

    2017-01-01

    W–3Lu 2 O 3 composites were prepared by mechanical milling and spark plasma sintering. The obtained composites were subjected to He + irradiation experiments. The irradiated samples were characterized by X-ray diffraction, field-emission scanning electron microscopy, transmission electron microscopy, and measurement of Vickers hardness. Thermal desorption spectroscopy analysis was performed to analyze the samples at different damage levels after Fe 2+ and D + irradiation. Results showed varied degrees of He + damage under different energies. Fuzz structures were observed on the surface of the material after irradiation. TEM results indicated that the existence of these fuzz structures was related to the formation of He bubbles. Amorphous, polycrystalline, and γ-W phases formed in areas where He bubbles existed. The measured Vickers hardness proved that radiation hardening occurred after irradiation. After Fe 2+ irradiation at different damage levels, the total retained deuterium amount of W–3Lu 2 O 3 and pure W differed, and the impact of Fe 2+ radiation for deuterium retention on pure tungsten was greater.

  11. Preparation and biological evaluation of {sup 177}Lu conjugated PR81 for radioimmunotherapy of breast cancer

    Energy Technology Data Exchange (ETDEWEB)

    Salouti, Mojtaba, E-mail: saloutim@yahoo.com [Department of Biology, Faculty of Sciences, Zanjan Branch, Islamic Azad University, Zanjan 45156-58145 (Iran, Islamic Republic of); Babaei, Mohammad Hossein [Nuclear Biomolecule Laboratory, Radioisotope Department, Nuclear Science and Technology Research Institute, Tehran 14144-1339 (Iran, Islamic Republic of); Rajabi, Hossein [Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14115-111 (Iran, Islamic Republic of); Rasaee, Mohammad javad [Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14115-111 (Iran, Islamic Republic of)

    2011-08-15

    Aim: PR81 is a monoclonal antibody that binds with high affinity to MUC1 antigen that is over expressed in 80% of breast cancers. In this study, we developed a method for indirect labeling of PR81 with lutetium-177 and performed all preclinical qualifications in production of a biologic agent for radioimmunotherapy of breast cancer. Materials and Methods: The radiochemical purity and in vitro stability of {sup 177}Lu labeled PR81 was determined by instant thin layer chromatography. The immunoreactivity and cell toxicity of the complex were tested on MCF7 cell line. The biodistribution and scintigraphy studies were performed in BALB/c mice with breast tumor. Results: The radiochemical purity was 91.2{+-}3.8% after 2 h. The in vitro stabilities in phosphate buffer and human blood serum were 83.1{+-}3.4% and 76.2{+-}3.6% at 96 h, respectively. The immunoreactivity of the complex was 83.4{+-}2.4%. The cell toxicity study showed that the complex inhibited 85.2{+-}3.4% growth of MCF7 cells at a concentration of 2500 ng/ml after 96 h. The biodistribution and scintigraphy studies showed the accumulation of the complex at the site of tumors with high sensitivity and specificity. Conclusion: The results showed that one may consider {sup 177}Lu-DOTA-PR81 as a potential radiopharmaceutical for therapy of human breast cancer, which needs further investigations.

  12. [Comparison of academic viewpoints between Yun Tie-qiao and Lu Yuan-lei].

    Science.gov (United States)

    Yang, Zhi-qing; Bi, Li-juan; Yang, Xing-lin

    2010-07-01

    Both Yun Tie-qiao and Lu Yuan-lei are medical professionals coming from the literary field with versatile and in-depth knowledge and extensive experience in medical education and clinical practice, all closely related to modern TCM development. Yun, the elder, insisted on reforming TCM and was early to advocate the academic idea of amalgamating western and traditional Chinese medicine; while Lu, the younger, insisted on the idea of "scientizing TCM" and was the representative of amalgamating western and traditional Chinese medicine in the later stage. They shared many common viewpoints, including venerating Zhang Zhongjing, stressing exogenous cold pathogens, advocating reformation and amalgamation of western medicine and TCM and objecting to the abolishment of TCM. However, there were discrepancies between them, including the relationship between the Inner Canon and the Essay on Exogenous Cold Diseases, warm disease theory, pulse theory, titles of TCM diseases and Japanese Kampo medicine. A comparison of them and noting their valuable contributions will be beneficial for the promotion of the development of TCM.

  13. Observation of magnetic polarons in the magnetoresistive pyrochlore Lu2V2O7

    International Nuclear Information System (INIS)

    Storchak, Vyacheslav G; Brewer, Jess H; Eshchenko, Dmitry G; Mengyan, Patrick W; Zhou Haidong; Wiebe, Christopher R

    2013-01-01

    Materials that exhibit colossal magnetoresistance (CMR) have attracted much attention due to their potential technological applications. One particularly interesting model for the magnetoresistance of low-carrier-density ferromagnets involves mediation by magnetic polarons (MP)—electrons localized in nanoscale ferromagnetic ‘droplets’ by their exchange interaction. However, MP have not previously been directly detected and their size has been difficult to determine from macroscopic measurements. In order to provide this crucial information, we have carried out muon spin rotation measurements on the magnetoresistive semiconductor Lu 2 V 2 O 7 in the temperature range from 2 to 300 K and in magnetic fields up to 7 T. Magnetic polarons with characteristic radius R ≈ 0.4 nm are detected below about 100 K, where Lu 2 V 2 O 7 exhibits CMR; at higher temperature, where the magnetoresistance vanishes, these MP also disappear. This observation confirms the MP-mediated model of CMR and reveals the microscopic size of the MP in magnetoresistive pyrochlores. (paper)

  14. Magnetic properties of amorphous alloys of Fe with La, Lu, Y, and Zr

    International Nuclear Information System (INIS)

    Heiman, N.; Kazama, N.

    1979-01-01

    In order to study the systematics of the Fe-Fe exchange in amorphous rare-earth--Fe alloys, without the complications associated with the magnetic characteristics of the rare-earth elements, amorphous films of Fe alloyed with La, Lu, Y, and Zr have been prepared with a wide range of Fe concentrations. Magnetization and Moessbauer-effect measurements were made. The magnetic properties of the alloys depended critically on the choice of rare earth (or rare-earth-like element). YFe and LuFe alloys were found to have spin-glass characteristics while LaFe and ZrFe alloys were found to be ferromagnetic, but with evidence that exchange fluctuations were nearly as large as the average exchange. Thus the nature of the Fe-Fe exchange interaction depends critically upon the species of the rare earth. The most important parameter in determining the magnetic behavior of these alloys appears to be the size of the rare-earth atom, with large rare-earth atoms resulting in a smaller ratio of exchange fluctuations to exchange. The same dependence of the magnetic properties upon rare-earth size appears to be important in the case of magnetic-rare-earth atoms; however, the effect of rare-earth--Fe exchange also becomes important and these effects are discussed

  15. Reducing Renal Uptake of {sup 177}Lu Labeled CCK Derivative using Basic Amino Acids

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Soyoung; Lim, Jaecheong; Joh, Eunha [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-05-15

    Radiolabeled peptides have been designed to target the relative receptors overespressed in tumor cells, such as integrin αvβ3, gastrin-releasing peptide receptor (GRPR), melanocortin-1 receptor (MC1-R), glucagon-like peptide-a receptor (GLP-1R), and cholecystokinin (CCK) receptor. Most of these peptides are eliminated from the body via the kidney and are partly reabsorbed in the proximal tubular cells. However, the high renal uptake of the radiolabeled peptides may lead to renal toxicity. In this study we investigated various amino acid solutions to reduce the renal uptake of {sup 177}Lu-DOTA-CCK derivative. Renal uptake of {sup 177}Lu-DOTA-CCK derivative is effectively reduced by the administration of positively charged amino acids. The administration of 12 mg of L-lysine was as effective in reducing the renal uptake as 6 mg of lysine and 6 mg of arginine combinations. Further studies will be performed to identify the most potent inhibitor of renal reuptake of radiolabeled peptides and minimize the chance of unwanted side effects.

  16. ARE PLASTIC GROCERY BAGS SACKING THE ENVIRONMENT?

    OpenAIRE

    Mangal Gogte

    2009-01-01

    This paper is oriented on analysis impacts of plastic bags on environment. In this paper is analyzed did plastic bags are so harmful, and what are the main ingredients of it. One part of this paper is oriented on effects of plastic bags and management of their usage. There is also made comparative analysis between impacts of plastic and paper bags on environment.

  17. Experiments with elasto-plastic oscillator

    DEFF Research Database (Denmark)

    Randrup-thomsen, Søren; Ditlevsen, Ove Dalager

    1996-01-01

    Plastic displacements of a Gaussian white noise excited three degrees of freedom non-ideal elasto-plastic oscillator are measured in laboratory experiments and the plastic displacements are compared to computer simulated results for the corresponding ideal elasto-plastic oscillator. The comparative...

  18. Experiments with elasto-plastic oscillator

    DEFF Research Database (Denmark)

    Randrup-Thomsen, S.; Ditlevsen, Ove Dalager

    1999-01-01

    Plastic displacements of a Gaussian white noise excited three degrees of freedom non-ideal elasto-plastic oscillator are measured in laboratory experiments and the plastic displacements are compared to computer simulated results for the corresponding ideal elasto-plastic oscillator. The comparative...

  19. Reply to Comment by Lu et al. on "An Efficient and Stable Hydrodynamic Model With Novel Source Term Discretization Schemes for Overland Flow and Flood Simulations"

    Science.gov (United States)

    Xia, Xilin; Liang, Qiuhua; Ming, Xiaodong; Hou, Jingming

    2018-01-01

    This document addresses the comments raised by Lu et al. (2017). Lu et al. (2017) proposed an alternative numerical treatment for implementing the fully implicit friction discretization in Xia et al. (2017). The method by Lu et al. (2017) is also effective, but not necessarily easier to implement or more efficient. The numerical wiggles observed by Lu et al. (2017) do not affect the overall solution accuracy of the surface reconstruction method (SRM). SRM introduces an antidiffusion effect, which may also lead to more accurate numerical predictions than hydrostatic reconstruction (HR) but may be the cause of the numerical wiggles. As suggested by Lu et al. (2017), HR may perform equally well if fine enough grids are used, which has been investigated and recognized in the literature. However, the use of refined meshes in simulations will inevitably increase computational cost and the grid sizes as suggested are too small for real-world applications.

  20. Plastic zonder olie : lesmodule voor nieuwe scheikunde

    OpenAIRE

    Langejan, B.; Klein Douwel, C.; Horst, ter, J.J.; Tijdink, K.; Marle, van, N.; Klaasen, P.; Coolen, R.; Assenbergh, van, P.; Sijbers, J.P.J.; Mast, A.

    2013-01-01

    Lesmodule voor nieuwe scheikunde voor leerlingen uit 5 en 6 vwo. Bioplastics worden gemaakt uit natuurlijke grondstoffen. Als ze de synthetische plastics vervangen kan de voorraad aardolie ontzien worden. Omdat veel bioplastics afbreekbaar zijn, kan ook de berg plastic afval krimpen. Maar zijn bioplastics in staat om ons de reguliere plastics te doen vergeten? Hoe maken we bioplastics met dezelfde veelzijdige eigenschappen als plastic? Waar komen de uiteenlopende eigenschappen van plastics ei...

  1. Elimination of Plastic Polymers in Natural Environments

    OpenAIRE

    Ramirez-Ekner, Sofia; Bidstrup, Marie Juliane Svea; Brusen, Nicklas Hald; Rugaard-Morgan, Zsa-Zsa Sophie Oona Ophelia

    2017-01-01

    Plastic production and consumption continues to rise and subsequently plastic waste continues to accumulates in natural environments, causing harm to ecosystems.The aim of this paper was to come up with a way to utilize organisms, that have been identified to produce plastic degrading enzymes, as a waste disposal technology. This review includes accounts of plastic production rates, the occurrence of plastic in natural environments and the current waste management systems to create an underst...

  2. An electro-amalgamation approach to isolate no-carrier-added {sup 177}Lu from neutron irradiated Yb for biomedical applications

    Energy Technology Data Exchange (ETDEWEB)

    Chakravarty, Rubel; Das, Tapas [Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Dash, Ashutosh, E-mail: adash@barc.gov.i [Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085 (India); Venkatesh, Meera [Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085 (India)

    2010-10-15

    Introduction: A novel two-step separation process for the production of no-carrier-added (NCA) {sup 177}Lu from neutron irradiated Yb target through an electrochemical pathway employing mercury-pool cathode has been developed. Methods: A two-cycle electrolysis procedure was adopted for separation of {sup 177}Lu from {sup 177}Lu/Yb mixture in lithium citrate medium. The influence of different experimental parameters on the separation process was investigated and optimized for the quantitative deposition of Yb in presence of {sup 177}Lu. The first electrolysis was performed for 50 min in the {sup 177}Lu/Yb feed solution at pH 6 applying a potential of 8 V using platinum electrode as anode and mercury as the cathode. The second electrolysis was performed under the same conditions using fresh electrodes. The radionuclidic and chemical purity of {sup 177}Lu was determined by using gamma ray spectrometry and atomic absorption spectrometry. The suitability of {sup 177}Lu for biomedical applications was ascertained by labeling 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid D-Phe{sup 1}-Tyr{sup 3}-octreotate(DOTA-TATE) with {sup 177}Lu. Results: This process could provide NCA {sup 177}Lu with >99.99% radionuclidic purity and an overall separation yield of {approx}99% was achieved within 3-4 h. The Hg content in the product was determined to be <1 ppm. Radiolabeling yield of >98% was obtained with DOTA-TATE under the optimized reaction conditions. Conclusions: An efficient strategy for the separation of NCA {sup 177}Lu, suitable for biomedical applications, has been developed.

  3. Avalanches and plastic flow in crystal plasticity: an overview

    Science.gov (United States)

    Papanikolaou, Stefanos; Cui, Yinan; Ghoniem, Nasr

    2018-01-01

    Crystal plasticity is mediated through dislocations, which form knotted configurations in a complex energy landscape. Once they disentangle and move, they may also be impeded by permanent obstacles with finite energy barriers or frustrating long-range interactions. The outcome of such complexity is the emergence of dislocation avalanches as the basic mechanism of plastic flow in solids at the nanoscale. While the deformation behavior of bulk materials appears smooth, a predictive model should clearly be based upon the character of these dislocation avalanches and their associated strain bursts. We provide here a comprehensive overview of experimental observations, theoretical models and computational approaches that have been developed to unravel the multiple aspects of dislocation avalanche physics and the phenomena leading to strain bursts in crystal plasticity.

  4. Scintillation properties of transparent Lu{sub 3}Al{sub 5}O{sub 12} (LuAG) ceramics doped with different concentrations of Pr{sup 3+}

    Energy Technology Data Exchange (ETDEWEB)

    Yanagida, Takayuki; Fukabori, Akihiro; Fujimoto, Yutaka; Kamada, Kei; Yokota, Yuui; Yoshikawa, Akira; Chani, Valery [IMRAM, Tohoku University, 2-1-1 Katahira Aoba-ku, 980-8577 Sendai (Japan); Ikesue, Akio [World Labo, Co. Ltd., Mutsuno 2-4-1, Atsuta, 456-0023 Nagoya (Japan); Kataoka, Jun [School of Advanced Science and Engineering,Waseda University, Ohkubo 3-4-1, Shinjuku, 169-0072 Tokyo (Japan)

    2011-01-15

    Transparent ceramics of Pr-doped (0.2 mol%, 0.6 mol%, 1 mol%, and 2 mol%) Lu{sub 3}Al{sub 5}O{sub 12} (LuAG) scintillators produced by the sintering method are discussed. These materials were cut to the specimens with physical dimensions of 5 x 5 x 2 mm{sup 3}. Similar size specimens were also prepared from Czochralski grown Pr:LuAG single crystals to compare scintillation properties. Their transmittance and radio luminescence spectra were evaluated. All specimens were highly transparent in wavelength range above 300 nm, and intense Pr{sup 3+} 5d-4f emission was detected around 310 and 370 nm under excitation with X-ray. Under {sup 137}Cs {gamma}-ray is irradiation, 2 keV photo-absorption peaks were also clearly observed in each sample. The Pr 0.6 mol% doped LuAG ceramics demonstrated highest light yield achievable among the ceramics, and it was half of that observed in the single crystals. Under pulse X-ray excitation, the decay time constants became faster when Pr concentration increased, and. the fastest decay ({proportional_to}5.7 ns time constant) was noticed in the 2 mol% doped ceramic. (copyright 2011 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  5. Occupational doses in neuroendocrine tumors by using {sup 177}Lu DOTATATE; Doses ocupacionais em tratamento de tumores neuroendocrinos utilizando {sup 17'}7Lu DOTATATE

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Gustavo Coelho Alves; Sa, Lidia Vasconcellos de, E-mail: gustavo@ird.gov.b, E-mail: lidia@ird.gov.b [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2011-10-26

    This paper investigated the treatment of neuroendocrine tumors (abdominal tumors) using of {sup 177}Lu DOTATATE radiopharmaceutical which is a type of treatment presently used in the experimental form in Brazil and, therefore, not contemplated in norms or specific use. This research studied the occupational doses of this treatment and suggested guidelines or rules of procedures viewing the radiological protection of workers involved and the public. The treatment were followed up by using two types of radiation detection, one a scintillator and a Geiger-Muller, and the measurements were performed in a public hospital at Rio de Janeiro and the other in a private hospital at Sao Paulo. It was observed that the equivalent occupational doses can variate from 160 {mu}Sv to 450 {mu}Sv, in function of operator, of stage of manipulation, and of the administration method, which can be through the use of infusion pump or manual injection. The use of infusion pump is highly recommended and the hospitalization of the patient until the dose rate measured at 1 m does not surpass 20 {mu}Sv/h

  6. Plasticity characteristic obtained by indentation

    International Nuclear Information System (INIS)

    Milman, Yu V

    2008-01-01

    A dimensionless parameter δ H = ε p /ε t (where ε p and ε t are the average values of plastic and total deformation of material on the contact area indenter-specimen) may be used as the plasticity characteristic of materials, which made it possible to characterize the plasticity of materials that are brittle in standard mechanical tests. δ H may be calculated from the values of microhardness HM, Young's modulus E and Poisson's ratio ν. In instrumented indentation the plasticity characteristic δ A = A p /A t (A p and A t are the work of plastic and total deformation during indentation) may be calculated. δ A ∼ δ H for materials with δ H > 0.5, i.e. for all metals and the majority of ceramic materials. In this case, the theoretical equation δ A ∼ δ H = 1-10.2 · (1 - ν - 2ν 2 )(HM/E) is satisfied in experiments with the Berkovich indenter. The influence of the temperature and structural parameters (dislocation density and grain size including nanostructured materials) on δ H is discussed

  7. Mechanisms of GABAergic Homeostatic Plasticity

    Directory of Open Access Journals (Sweden)

    Peter Wenner

    2011-01-01

    Full Text Available Homeostatic plasticity ensures that appropriate levels of activity are maintained through compensatory adjustments in synaptic strength and cellular excitability. For instance, excitatory glutamatergic synapses are strengthened following activity blockade and weakened following increases in spiking activity. This form of plasticity has been described in a wide array of networks at several different stages of development, but most work and reviews have focussed on the excitatory inputs of excitatory neurons. Here we review homeostatic plasticity of GABAergic neurons and their synaptic connections. We propose a simplistic model for homeostatic plasticity of GABAergic components of the circuitry (GABAergic synapses onto excitatory neurons, excitatory connections onto GABAergic neurons, cellular excitability of GABAergic neurons: following chronic activity blockade there is a weakening of GABAergic inhibition, and following chronic increases in network activity there is a strengthening of GABAergic inhibition. Previous work on GABAergic homeostatic plasticity supports certain aspects of the model, but it is clear that the model cannot fully account for some results which do not appear to fit any simplistic rule. We consider potential reasons for these discrepancies.

  8. Neurogenomic mechanisms of social plasticity.

    Science.gov (United States)

    Cardoso, Sara D; Teles, Magda C; Oliveira, Rui F

    2015-01-01

    Group-living animals must adjust the expression of their social behaviour to changes in their social environment and to transitions between life-history stages, and this social plasticity can be seen as an adaptive trait that can be under positive selection when changes in the environment outpace the rate of genetic evolutionary change. Here, we propose a conceptual framework for understanding the neuromolecular mechanisms of social plasticity. According to this framework, social plasticity is achieved by rewiring or by biochemically switching nodes of a neural network underlying social behaviour in response to perceived social information. Therefore, at the molecular level, it depends on the social regulation of gene expression, so that different genomic and epigenetic states of this brain network correspond to different behavioural states, and the switches between states are orchestrated by signalling pathways that interface the social environment and the genotype. Different types of social plasticity can be recognized based on the observed patterns of inter- versus intra-individual occurrence, time scale and reversibility. It is proposed that these different types of social plasticity rely on different proximate mechanisms at the physiological, neural and genomic level. © 2015. Published by The Company of Biologists Ltd.

  9. Smartphones and the plastic surgeon.

    Science.gov (United States)

    Al-Hadithy, Nada; Ghosh, Sudip

    2013-06-01

    Surgical trainees are facing limited training opportunities since the introduction of the European Working Time Directive. Smartphone sales are increasing and have usurped computer sales for the first time. In this context, smartphones are an important portable reference and educational tool, already in the possession of the majority of surgeons in training. Technology in the palm of our hands has led to a revolution of accessible information for the plastic surgery trainee and surgeon. This article reviews the uses of smartphones and applications for plastic surgeons in education, telemedicine and global health. A comprehensive guide to existing and upcoming learning materials and clinical tools for the plastic surgeon is included. E-books, podcasts, educational videos, guidelines, work-based assessment tools and online logbooks are presented. In the limited resource setting of modern clinical practice, savvy plastic surgeons can select technological tools to democratise access to education and best clinical care. Copyright © 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  10. A mística em Agustina Bessa-Luís e Clarice Lispector

    Directory of Open Access Journals (Sweden)

    Maria Lúcia Dal Farra

    2014-12-01

    Full Text Available Se trata de examinar la aproximación a la condición de mujer en dos escritoras de la misma generación: la brasileña Clarice Lispector (nacida en 1920 y la portuguesa Agustina Bessa-Luís (nacida en 1922. Son objeto de estudio las respectivas novelas que publican en un mismo período: La sibila, de Agustina, es de 1954, y La pasión según G.H., de Clarice, es de 1964. A través de estrategias narrativas y discursivas muy diversas, cada obra se vale de la temática de la naturaleza mística (que envuelve lo femenino para solapar las bases culturales, estructurales e ideológicas de donde parten, exponiendo la inadaptación al mundo estabilizado y demoliendo el código novelesco. Trata-se de examinar a abordagem da condição concernente à mulher em duas escritoras da mesma geração: a brasileira Clarice Lispector (nascida em 1920 e a portuguesa Agustina Bessa-Luís (nascida em 1922. São objeto do estudo os respectivos romances que publicam numa mesma faixa temporal: A sibila, de Agustina, é de 1954, e A paixão segundo G.H., de Clarice, é de 1964. Cada obra, através de estratégicas narrativas e discursivas muito diversas, se vale da temática da natureza mística (que envolve o feminino para solapar as bases culturais, estruturais e ideológicas de onde partem, expondo a inadaptação ao mundo estabilizado e desmanchando o código romanesco. This article examines how two female writers from the same generation approach the feminine condition: the Brazilian Clarice Lispector (born in 1920 and the Portuguese Agustina Bessa-Luís (born in 1922. The analysis focuses on two of their novels published in the same time period: La Sibila, by Agustina, was written in 1954, and La Pasión Según G.H., by Clarice, was written in 1964. Through diverse narrative and discursive strategies, these two works explore the mystical nature (which encompasses the feminine condition in order to address the cultural, structural and ideological grounds from

  11. Hypocalcaemia after treatment with [{sup 177}Lu-DOTA{sup 0},Tyr{sup 3}]octreotate

    Energy Technology Data Exchange (ETDEWEB)

    Vliet, Esther I. van; Kam, Boen L.R.; Teunissen, Jaap J.M.; Krenning, Eric P.; Kwekkeboom, Dik J. [Erasmus MC, University Medical Center, Department of Nuclear Medicine, Rotterdam (Netherlands); Herder, Wouter W. de; Zillikens, M.C.; Peeters, Robin P. [Erasmus MC, University Medical Center, Department of Internal Medicine, Rotterdam (Netherlands); Rijke, Yolanda B. de [Erasmus MC, University Medical Center, Department of Clinical Chemistry, Rotterdam (Netherlands)

    2013-12-15

    The aim of this study was to explore the possible mechanisms involved in an observed decline in serum calcium levels in patients with a neuroendocrine tumour (NET) treated with [{sup 177}Lu-DOTA{sup 0},Tyr{sup 3}]octreotate ({sup 177}Lu-octreotate). In 47 patients with NET who were normocalcaemic at baseline, serum calcium, albumin, creatinine, alkaline phosphatase, gamma glutamyl transpeptidase, magnesium, phosphate and 25-hydroxyvitamin D were prospectively analysed at baseline and up to 6 months after treatment. Parathyroid hormone (PTH), 1,25-dihydroxyvitamin D{sub 3}, type 1 aminoterminal propeptide of procollagen, bone-specific alkaline phosphatase, carboxyterminal crosslinking telopeptide of bone collagen, collagen type I crosslinked N-telopeptide, and creatinine and calcium in 24-h urine samples, were evaluated at baseline and at 3 and 6 months. Another 153 patients with NET were included in a retrospective study to estimate the occurrence of hypocalcaemia in a larger patient group. In the prospectively included patients, the mean serum calcium level decreased significantly after treatment (2.31 {+-} 0.01 to 2.26 {+-} 0.02 mmol/l, p = 0.02). Eight patients (17 %) showed a marked decrease in serum calcium levels with a nadir of {<=}2.10 mmol/l. In five patients (11 %), calcium substitution therapy was prescribed. PTH increased significantly (5.9 {+-} 0.6 to 6.7 {+-} 0.8 pmol/l, p = 0.02), presumably in response to the decreasing serum calcium levels. 25-Hydroxyvitamin D remained stable after treatment. Creatinine levels increased significantly (73 {+-} 3 to 77 {+-} 3 {mu}mol/l, p = 0.01), but not enough to explain the hypocalcaemia. Phosphate levels remained unaffected. In the retrospectively analysed patients, the mean serum calcium level decreased significantly from 2.33 {+-} 0.01 at baseline to a nadir of 2.24 {+-} 0.01 mmol/l at 18 months after treatment (p < 0.001). Of the 153 patients, 33 (22 %) showed a serum calcium nadir of {<=}2.10 mmol/l, and 11

  12. Fabrication and scintillation properties of highly transparent Pr:LuAG ceramics using Sc,La-based isovalent sintering aids

    Czech Academy of Sciences Publication Activity Database

    Shen, Y.; Feng, X.; Babin, Vladimir; Nikl, Martin; Vedda, A.; Moretti, F.; Dell'Orto, E.; Pan, Y.; Li, J.; Zeng, Y.

    2013-01-01

    Roč. 39, č. 5 (2013), s. 5985-5990 ISSN 0272-8842 R&D Projects: GA MŠk LH12185; GA AV ČR KAN300100802 Institutional support: RVO:68378271 Keywords : Pr:LuAG transparent ceramics * isovalent sintering aids * scintillation Subject RIV: BH - Optics, Masers, Lasers Impact factor: 2.086, year: 2013

  13. ESR and TSL study of hole and electron traps in LuAG:Ce,Mg ceramic scintillator

    Czech Academy of Sciences Publication Activity Database

    Hu, C.; Liu, S.-P.; Fasoli, M.; Vedda, A.; Nikl, Martin; Feng, X. Q.; Pan, Y.B.

    2015-01-01

    Roč. 45, Jul (2015), s. 252-257 ISSN 0925-3467 R&D Projects: GA ČR GAP204/12/0805 Institutional support: RVO:68378271 Keywords : LuAG * scintillator * codoping * Ce3+ * O- center Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.183, year: 2015

  14. Effect of Mg.sup.2+./sup. co-doping on the scintillation performance of LuAG:Ce ceramics

    Czech Academy of Sciences Publication Activity Database

    Liu, S.; Feng, X.; Zhou, Z.; Nikl, Martin; Shi, Y.; Pan, Y.

    2014-01-01

    Roč. 8, č. 1 (2014), s. 105-109 ISSN 1862-6254 R&D Projects: GA MŠk LH12185 Institutional support: RVO:68378271 Keywords : Lu 3 Al 5 O 12 ceramics * cerium doping * acceptor levels * luminescence centers Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.142, year: 2014

  15. Effect of oxygen on tuning the TiNx metal gate work function on LaLuO3

    International Nuclear Information System (INIS)

    Mitrovic, I.Z.; Przewlocki, H.M.; Piskorski, K.; Simutis, G.; Dhanak, V.R.; Sedghi, N.; Hall, S.

    2012-01-01

    This paper presents experimental evidence on effective work function tuning due to the presence of oxygen at the TiNx/LaLuO 3 interface. Two complementary techniques, internal photoemission and X-ray photoelectron spectroscopy, show good agreement on the position of the metal gate Fermi level to conduction (2.79 ± 0.25 eV) and valence (2.65 ± 0.08 eV) band edge for TiNx/bulk LaLuO 3 gate stacks. The chemical shifts of Ti2p and N1s core levels and different degree in ionicity of TiNx metal gates correlate with the observed valence band offset shifts. The results have significance for setting the band edge work function and resulting low threshold voltage for ultimately scaled LaLuO 3 -based p-metal oxide semiconductor field effect transistor devices. - Highlights: ► The conduction band offset measured by internal photoemission. ► The valence band offset (VBO) measured by X-ray photoelectron spectroscopy. ► Different degree in ionicity of TiNx correlates with the VBO shifts. ► The effective work function of the gate stacks varies from 4.6 to 5.2 eV. ► Oxygen at the TiNx/LaLuO 3 interface increases effective work function.

  16. Gamma induced atom displacements in LYSO and LuYAP crystals as used in medical imaging applications

    Energy Technology Data Exchange (ETDEWEB)

    Piñera, Ibrahin, E-mail: ipinera@ceaden.edu.cu [Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear, CEADEN, 30 St. 502, Playa 11300, Havana (Cuba); Cruz, Carlos M.; Abreu, Yamiel; Leyva, Antonio [Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear, CEADEN, 30 St. 502, Playa 11300, Havana (Cuba); Van Espen, Piet [University of Antwerp, CGB, Groenenborgerlaan 171, 2020 Antwerpen (Belgium); Díaz, Angelina; Cabal, Ana E. [Centro de Aplicaciones Tecnológicas y Desarrollo Nuclear, CEADEN, 30 St. 502, Playa 11300, Havana (Cuba); Van Remortel, Nick [University of Antwerp, CGB, Groenenborgerlaan 171, 2020 Antwerpen (Belgium)

    2015-08-01

    The radiation damage, in terms of atom displacements, induced by gamma irradiation in LYSO and LuYAP crystals is presented. {sup 44}Sc, {sup 22}Na and {sup 48}V are used as gamma sources for this study. The energy of gammas from the electron–positron annihilation processes (511 keV) is also included in the study. The atom displacements distributions inside each material are calculated following the Monte Carlo assisted Classical Method introduced by the authors. This procedure also allows to study the atom displacements in-depth distributions inside each crystal. The atom displacements damage in LYSO crystals is found to be higher than in LuYAP crystals, mainly provoked by the displacements of silicon and oxygen atoms. But the difference between atom displacements produced in LYSO and LuYAP decreases when more energetic sources are used. On the other hand, the correlation between the atom displacements and energy deposition in-depth distributions is excellent. The atom displacements to energy deposition ratio is found to increases with more energetic photon sources. LYSO crystals are then more liable to the atom displacements damage than LuYAP crystals.

  17. 177Lu-DTPA-BIS-BIOTIN Binding of Octreotide-dextran-avidinated PANC-1 Cell Lines in Vitro

    International Nuclear Information System (INIS)

    Deng Xinrong; Zhai Shizhen; Shen Yijia; Luo Zhifu; Du Jin

    2011-01-01

    Tyr3-octreotide, dextran-40 and avidin were used to prepare octreotide-dextran-avidin (TOC-Dx 40 -Av). DTPA-BIS-BIOTIN was labelled with 177 Lu. The in vitro somatostatin receptor binding study was carried out by pretargeted method using TOC-Dx 40 -Av and 177 Lu-DTPA-BIS-BIOTIN. The 24 well cell culture plates were prepared with PANC-1 cell monolayer and then incubated with TOC-Dx 40 -Av. After two washed with PBS, the cells were incubated with different concentration of 177 Lu-DTPA-BIS-BIOTIN (48.8 ∼ 391 pmol). Cells uptake was evaluated with γ counter. The results showed that the chemical purity of TOC-Dx 40 -Av was over 99%. The results also showed that TOC-Dx 40 -Av remained high receptor binding affinity to somatostatin receptor which indicated that TOC- Dx 40 -Av could bind to 177 Lu-DTPA-BIS-BIOTIN with the molar ratio of 1 : 1 on the cell surface. (authors)

  18. Preclinical Evaluation of (177)Lu-Nimotuzumab: A Potential Tool for Radioimmunotherapy of Epidermal Growth Factor Receptor-Overexpressing Tumors

    Czech Academy of Sciences Publication Activity Database

    Beckford, Denis R.; Eigner, Sebastian; Beran, Miloš; Eigner-Henke, Kateřina; Lázníček, M.; Melichar, František; Chinol, M.

    2011-01-01

    Roč. 26, č. 3 (2011), s. 287-297 ISSN 1084-9785 R&D Projects: GA MŠk OE08018 Institutional research plan: CEZ:AV0Z10480505 Keywords : EGFR * (177)Lu * monoclonal antibodies * Nimotuzumab Subject RIV: FR - Pharmacology ; Medidal Chemistry Impact factor: 1.787, year: 2011

  19. In-band pumping of expitaxially grown Er:(Gd,Lu)2O3 waveguides for active integrated optical devices

    NARCIS (Netherlands)

    Kahn, A.; Kühn, H.; Heinrich, S.; Gün, T.; Tellkamp, F.; Petermann, K.; Bradley, J.; Ay, F.; Worhoff, Kerstin; Pollnau, Markus; Kuzminykh, Y.; Luo, Y.; Hoffmann, P.; Huber, G.

    Monocrystalline lattice matched Er(0.6%):(Gd, Lu)2O3 films with thicknesses up to 3 �?�m and nearly atomically flat surfaces have been deposited on Y2O3 substrates by Pulsed Laser Deposition (PLD). The epitaxial growth has been verified in-situ by Reflection High Energy Electron Diffraction (RHEED).

  20. Siim Nestor soovitab : uute eesti plaatide esitlusõhtud! Metro Luminal. Lu : K. Metsatöll / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2004-01-01

    Rockansambli Metro Luminal plaadi "Reboot" esitlusest Tartu Sadamateatris 9. dets. ja Rock Café's Tallinnas 10. dets.(kaasa teeb DJ Sing). Popansambli Lu:k albumist "Raadiomaja valvelauas" ja ansambli 10. aastapäeva tähistamisest 10. dets. Tallinnas Kunstiakadeemia saalis. Ansambli Metsatöll albumi "Hiiekoda" esitlusest 11.dets. Rock Café's Tallinnas

  1. Scintillation response of Ce3+ doped GdGa-LuAG multicomponent garnet films under e-beam excitation

    Czech Academy of Sciences Publication Activity Database

    Kučera, M.; Onderišinová, Z.; Bok, Jan; Hanuš, M.; Schauer, Petr; Nikl, Martin

    169 Part B, JAN 2016 (2016), s. 674-677 ISSN 0022-2313 Institutional support: RVO:68081731 ; RVO:68378271 Keywords : multicomponent garnets * cathodoluminescence * LuAG:Ce * scintillation * liquidphaseepitaxy Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 2.686, year: 2016

  2. Acupuncture points in the book of Şerefeddin Sabuncuoğlu, a 15th century Turkish physician.

    Science.gov (United States)

    Acar, H Volkan

    2015-02-01

    Şerefeddin Sabuncuoğlu (1385-1468?), the author of Cerrahiyetü'l-Haniyye (Imperial Surgery), was a distinguished Ottoman Turkish surgeon. The first illustrated Turkish surgical textbook, Cerrahiyetü'l-Haniyye consisted of three chapters (ie, cauterisation treatments, surgical procedures and fractures and dislocations). Although the main source of the book was Al-Tasrif (Textbook of Surgery) by Albucasis (Abu al-Qasim al-Zahrawi; 936-1013 AD), Sabuncuoğlu added much new information, his clinical experiences and suggestions. The original illustrations and human figures made Cerrahiyetü'l-Haniyye the first illustrated medical textbook in Turkish and Islamic medicine literature. Cerrahiyetü'l-Haniyye was also a valuable source for acupuncturists. Some new sections and additions revealed that Sabuncuoğlu had knowledge of Chinese medicine. In four sections of Cerrahiyetü'l-Haniyye (ie, toothache, haemorrhoids, eczema and dermatophytosis) Sabuncuoğlu described acupuncture techniques and point locations. It is likely that the Chinese medicine content of Cerrahiyetü'l-Haniyye was derived from Central Asian roots of Anatolian Turkish people. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  3. Delayed response after repeated {sup 177}Lu-PSMA-617 radioligand therapy in patients with metastatic castration resistant prostate cancer

    Energy Technology Data Exchange (ETDEWEB)

    Rahbar, Kambiz; Schaefers, Michael [University Hospital Muenster, Department of Nuclear Medicine, Muenster (Germany); Boegeman, Martin [University Hospital Muenster, Department of Urology, Muenster (Germany); Yordanova, Anna; Essler, Markus; Ahmadzadehfar, Hojjat [University Hospital Bonn, Department of Nuclear Medicine, Bonn (Germany); Eveslage, Maria [University Hospital Muenster, Institute for Biostatistics, Muenster (Germany)

    2018-02-15

    Radioligand therapy (RLT) using Lutetium-177 labeled PSMA-617 (Lu-PSMA) ligand is a new therapeutic option for salvage therapy in heavily pretreated patients with metastatic castration resistant prostate cancer. The aim of this retrospective study was to analyze response in patients receiving 3 cycles of Lu-PSMA. Seventy-one patients (median age: 72 years; range 44-87) received 3 cycles of RLT with Lu-PSMA (mean administered activity: 6.016 ± 0.543 GBq) every 8 weeks. Response was evaluated using serum PSA levels and a PSA decline ≥50% was considered as biochemical response. Additionally, any PSA decline after the first cycle was evaluated for further therapy effects after the second and third cycle. A total of 213 cycles were performed in 71 patients. Data for response and adverse events were available for all patients. A PSA decline ≥50% and some PSA decline occurred in 56% and 66% of the patients. Of 30 patients with a PSA response after the first cycle, 28 remained responders and 12/41 of non-responders responded to further therapy cycles. RLT with Lu-177-PSMA-617 shows respectable response rates. In this retrospective analysis, a relevant number of patients showed a delayed response, even if they did not respond to the first cycle of the therapy. (orig.)

  4. Multicolor upconversion emission of dispersed ultrasmall cubic Sr2LuF7 nanocrystals synthesized by a solvothermal process

    International Nuclear Information System (INIS)

    Gong, Lunjun; Ma, Mo; Xu, Changfu; Li, Xujun; Wang, Suiping; Lin, Jianguo; Yang, Qibin

    2013-01-01

    Lanthanide (Ln 3+ ) doped Sr 2 LuF 7 (Ln 3+ =Er 3+ /Tm 3+ /Yb 3+ ) nanocrystals (NCs) were synthesized via a solvothermal process using oleate as stabilizing agent. The as-synthesized NCs with a mean diameter of sub-20 nm can be well dispersed in cyclohexane and show a pure cubic phase structure with space group Fm3 ¯ m. Following appropriate lanthanide ion doping, the NCs show intense red, green, blue and white-color upconversion emission (UC) under the excitation of a 980 nm laser. Predominant near-infrared UC can also be obtained in the Yb 3+ /Tm 3+ doped Sr 2 LuF 7 NCs. The energy transfer UC mechanisms for the fluorescent intensity were also investigated. The desirable property of the ultrasmall dispersed NCs makes them promising materials for the applications in miniaturized solid-state light sources, multicolor three-dimensional display devices and fluorescent labels for biomedical imaging. - Highlights: ► Cubic-structure (Fm3 ¯ m) Sr 2 LuF 7 nanocrystals were synthesized for the first time. ► Nanocrystals (sub-20 nm) with cubic or spherical shape can be well dispersed. ► By doping properly, the nanocrystals show intense multicolor upconversion. ► Predominant near-infrared upconversion can be obtained in Sr 2 LuF 7 nanocrystals. ► Upconversion mechanism for the fluorescent intensity is mainly energy transfer.

  5. Relativistic double-zeta, triple-zeta, and quadruple-zeta basis sets for the lanthanides La–Lu

    NARCIS (Netherlands)

    Dyall, K.G.; Gomes, A.S.P.; Visscher, L.

    2010-01-01

    Relativistic basis sets of double-zeta, triple-zeta, and quadruple-zeta quality have been optimized for the lanthanide elements La-Lu. The basis sets include SCF exponents for the occupied spinors and for the 6p shell, exponents of correlating functions for the valence shells (4f, 5d and 6s) and the

  6. Rodents from the Upper Miocene Tuğlu Formation (Çankırı Basin, Central Anatolia, Turkey)

    NARCIS (Netherlands)

    Joniak, Peter; de Bruijn, Hans

    2015-01-01

    The upper Miocene assemblages of rodents collected from two layers of the type section of the Tuğlu Formation (Çankırı Basin, Central Anatolia, Turkey) are described. The assemblage from the lower level is considerably less diverse than that from the upper level. It contains Progonomys together with

  7. Study of interfaces and band offsets in TiN/amorphous LaLuO3 gate stacks

    KAUST Repository

    Mitrovic, Ivona Z.; Simutis, G.; Davey, W. M.; Sedghi, Naser; Hall, Stephen D.; Dhanak, Vinod R.; Alexandrou, Ioannis; Wang, Qingxiao; Lopes, Joao Marcelo J.; Schubert, Jü rgen M.

    2011-01-01

    sub-peak which relates to Ti bond to interstitial oxygen have been identified for an ultra-thin 1.7 nm TiN/3 nm LLO gate stack. The angle-dependent XPS analysis of Si2s spectra as well as shifts of La4d, La3d and Lu4d core levels suggests a silicate-type

  8. Exercise and plasticize the brain

    DEFF Research Database (Denmark)

    Mala, Hana; Wilms, Inge

    Neuroscientific studies continue to shed light on brain’s plasticity and its innate mechanisms to recover. The recovery process includes re-wiring of the existing circuitry, establishment of new connections, and recruitment of peri-lesional and homologous areas in the opposite hemisphere....... The plasticity of the brain can be stimulated and enhanced through training, which serves as a fundamental element of neurorehabilitative strategies. For instance, intensive cognitive and physical training promote the activation of processes that may help the brain to adapt to new conditions and needs. However...... neurorehabilitation is to understand and define how to stimulate the injured brain to elicit the desired adaptation. Research focuses on uncovering specific elements relevant for training planning and execution in order to create an environment that stimulates and maximizes the exploitation of the brain’s plastic...

  9. Surface properties of beached plastics.

    Science.gov (United States)

    Fotopoulou, Kalliopi N; Karapanagioti, Hrissi K

    2015-07-01

    Studying plastic characteristics in the marine environment is important to better understand interaction between plastics and the environment. In the present study, high-density polyethylene (HDPE), polyethylene terephalate (PET), and polyvinyl chloride (PVC) samples were collected from the coastal environment in order to study their surface properties. Surface properties such as surface functional groups, surface topography, point of zero charge, and color change are important factors that change during degradation. Eroded HDPE demonstrated an altered surface topography and color and new functional groups. Eroded PET surface was uneven, yellow, and occasionally, colonized by microbes. A decrease in Fourier transform infrared (FTIR) peaks was observed for eroded PET suggesting that degradation had occurred. For eroded PVC, its surface became more lamellar and a new FTIR peak was observed. These surface properties were obtained due to degradation and could be used to explain the interaction between plastics, microbes, and pollutants.

  10. The Prism Plastic Calorimeter (PPC)

    CERN Multimedia

    2002-01-01

    This proposal supports two goals: \\\\ \\\\ First goal:~~Demonstrate that current, widely used plastic technologies allow to design Prism Plastic Calorimeter~(PPC) towers with a new ``liquid crystal'' type plastic called Vectra. It will be shown that this technique meets the requirements for a LHC calorimeter with warm liquids: safety, hermeticity, hadronic compensation, resolution and time response. \\\\ \\\\ Second goal:~~Describe how one can design a warm liquid calorimeter integrated into a LHC detector and to list the advantages of the PPC: low price, minimum of mechanical structures, minimum of dead space, easiness of mechanical assembly, accessibility to the electronics, possibility to recirculate the liquid. The absorber and the electronic being outside of the liquid and easily accessible, one has maximum flexibility to define them. \\\\ \\\\ The R&D program, we define here aims at showing the feasibility of these new ideas by building nine towers of twenty gaps and exposing them to electron and hadron beams.

  11. Plastic solidification of radioactive wastes

    International Nuclear Information System (INIS)

    Moriyama, Noboru

    1981-01-01

    Over 20 years have elapsed after the start of nuclear power development, and the nuclear power generation in Japan now exceeds the level of 10,000 MW. In order to meet the energy demands, the problem of the treatment and disposal of radioactive wastes produced in nuclear power stations must be solved. The purpose of the plastic solidification of such wastes is to immobilize the contained radionuclides, same as other solidification methods, to provide the first barrier against their move into the environment. The following matters are described: the nuclear power generation in Japan, the radioactive wastes from LWR plants, the position of plastic solidification, the status of plastic solidification in overseas countries and in Japan, the solidification process for radioactive wastes with polyethylene, and the properties of solidified products, and the leachability of radionuclides in asphalt solids. (J.P.N.)

  12. Constraints on the evolution of phenotypic plasticity

    DEFF Research Database (Denmark)

    Murren, Courtney J; Auld, Josh R.; Callahan, Hilary S

    2015-01-01

    Phenotypic plasticity is ubiquitous and generally regarded as a key mechanism for enabling organisms to survive in the face of environmental change. Because no organism is infinitely or ideally plastic, theory suggests that there must be limits (for example, the lack of ability to produce...... an optimal trait) to the evolution of phenotypic plasticity, or that plasticity may have inherent significant costs. Yet numerous experimental studies have not detected widespread costs. Explicitly differentiating plasticity costs from phenotype costs, we re-evaluate fundamental questions of the limits...... to the evolution of plasticity and of generalists vs specialists. We advocate for the view that relaxed selection and variable selection intensities are likely more important constraints to the evolution of plasticity than the costs of plasticity. Some forms of plasticity, such as learning, may be inherently...

  13. Plasticity Theory of Fillet Welds

    DEFF Research Database (Denmark)

    Hansen, Thomas

    2005-01-01

    a safe and statically admissible stress distribution is established. The plasticity solutions are compared with tests carried out at the Engineering Academy of Denmark, Lyngby, in the early nineties, and old fillet weld tests. The new failure conditions are in very good agreement with the yield load......This paper deals with simple methods for calculation of fillet welds based on the theory of plasticity. In developing the solutions the lower-bound theorem is used. The welding material and parts of the base material are subdivided into triangular regions with homogeneous stress fields; thereby...... tests, but not so good agreement with the old failure load tests....

  14. The Plastic Tension Field Method

    DEFF Research Database (Denmark)

    Hansen, Thomas

    2005-01-01

    This paper describes a calculation method for steel plate girders with transverse web stiffeners subjected to shear. It may be used for predicting the failure load or, as a design method, to determine the optimal amount of internal web stiffeners. The new method is called the plastic tension field...... method. The method is based on the theory of plasticity and is analogous to the so-called diagonal compression field method developed for reinforced concrete beams with transverse stirrups, which is adopted in the common European concrete code (Eurocode 2). Many other theories have been developed...

  15. Preparation of coloured wood plastics

    International Nuclear Information System (INIS)

    Lebedev, V.T.; Filippova, T.G.; Rajchuk, F.Z.

    1977-01-01

    A study has been made into the possibility of using fat, as well as alcohol- and water-soluble dyes for radiation-chemical dying of polymers and plastics filled with wood. The use of fat-soluble azo and anthraquinone dyes permits obtaining intensely colored wood-plastic materials based on methyl methacrylate by way of gamma radiation with doses of up to 3 Mrad. At a dose above 5 Mrad, a marked tarnishing of the dye or a change in color and stains are observed. Dyes in styrene withstand higher radiation doses without any significant destruction

  16. In vitro characterization of 177Lu-radiolabelled chimeric anti-CD20 monoclonal antibody and a preliminary dosimetry study

    International Nuclear Information System (INIS)

    Forrer, Flavio; Mueller-Brand, Jan; Chen, Jianhua; Fani, Melpomeni; Powell, Pia; Maecke, Helmut R.; Lohri, Andreas; Moldenhauer, Gerhard

    2009-01-01

    131 I- and 90 Y-labelled anti-CD20 antibodies have been shown to be effective in the treatment of low-grade, B-cell non-Hodgkin's lymphoma (NHL). However, the most appropriate radionuclide in terms of high efficiency and low toxicity has not yet been established. In this study we evaluated an immunoconjugate formed by the anti-CD20 antibody rituximab and the chelator DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid). DOTA-rituximab was prepared as a kit formulation and can be labelled in a short time ( 177 Lu or 90 Y. Immunoconjugates with different numbers of DOTA molecules per rituximab were prepared using p-SCN-Bz-DOTA. In vitro immunoreactivity and stability were tested and preliminary dosimetric results were acquired in two patients. The immunological binding properties of DOTA-rituximab to the CD20 antigen were found to be retained after conjugation with up to four chelators. The labelled product was stable against a 10 5 times excess of diethylenetriaminepentaacetic acid (DTPA, 37 C, 7 days). Two patients with relapsed NHL were treated with 740 MBq/m 2 body surface 177 Lu-DOTA-rituximab. Scintigraphic images showed specific uptake at tumour sites and acceptable dosimetric results. The mean whole-body dose was found to be 314 mGy. The administration of 177 Lu-DOTA-rituximab was tolerated well. Our results show that DOTA-rituximab (4:1) can be labelled with 177 Lu with sufficient stability while the immunoconjugate retains its immunoreactivity. 177 Lu-DOTA-rituximab is an interesting, well-tolerated radiolabelled antibody with clinical activity in a low dose range, and provides an approach to the efficient treatment with few side effects for patients with relapsed NHL. (orig.)

  17. Comparative optical study of thulium-doped YVO4 , GdVO4 , and LuVO4 single crystals

    Science.gov (United States)

    Lisiecki, R.; Solarz, P.; Dominiak-Dzik, G.; Ryba-Romanowski, W.; Sobczyk, M.; Černý, Pavel; Šulc, Jan; Jelínková, Helena; Urata, Yoshiharu; Higuchi, Mikio

    2006-07-01

    YVO4:Tm3+ crystals grown by the Czochralski technique and GdVO4:Tm3+ and LuVO4:Tm3+ crystals grown by the floating-zone technique were investigated using methods of optical spectroscopy. Polarized absorption and emission spectra were recorded at room temperature and at 6K . The crystal-field analysis was performed assuming the D2d site symmetry for Tm3+ ions. In this way the missing crystal-field components of the H63 ground multiplet were located. Room temperature absorption spectra were analyzed in the framework of the Judd-Ofelt theory. Evaluated radiative lifetimes of luminescent levels of Tm3+ follow a general trend diminishing in agreement with the sequence: YVO4:Tm3+→GdVO4:Tm3+→LuVO4:Tm3+ . Luminescence lifetimes measured for the systems under study are similar except for the F43 lifetime, which appears to be surprisingly short for LuVO4:Tm3+ . Anisotropy of optical spectra is particularly pronounced in LuVO4:Tm3+ . Peak absorption cross section for the band relevant for optical pumping at about 805nm is roughly three times higher for π polarization. Stimulated emission cross sections for the F43-H63 transition near 1800nm were evaluated using the reciprocity method. The diode-pumped continuous wave laser operation in GdVO4:Tm3+ with a slope efficiency of up to 40% is demonstrated. In LuVO4:Tm3+ the diode-pumped laser oscillation in a pulsed mode was observed.

  18. Preparation and bioevaluation of {sup 177}Lu-labelled anti-CD44 for radioimmunotherapy of colon cancer

    Energy Technology Data Exchange (ETDEWEB)

    Lee, So Young; Hong, Young Don; Jung, Sung Hee; Choi, Sun Ju [Radioisotope Research Division, Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-12-15

    CD44 is a particular adhesion molecule and facilitates both cell-cell and cell-matrix interactions. In particular, splice variants of CD44 are particularly overexpressed in a large number of malignancies and carcinomas. In this study, the {sup 177}Lu-labelled CD44 targeting antibody was prepared and bioevaluated in vitro and in vivo. Anti-CD44 was immunoconjugated with the equivalent molar ratio of cysteine-based dtPA-ncS and radioimmunoconjugated with {sup 177}Lu at room temperature within 15 minutes. the stability was tested in human serum. An in vitro study was carried out in Ht-29 human colon cancer cell lines. For the biodistribution study {sup 177}Lu-labelled anti-CD44 was injected in xenograft mice. Anti-CD44 was immunoconjugated with cysteinebased dtPA-ncS and purified by a centricon filter system having a molecular cut-off of 50 kda. radioimmunoconjugation with {sup 177}Lu was reacted for 15 min at room temperature. the radiolabeling yield was >99%, and it was stable in human serum without any fragmentation or degradation. The radioimmunoconjugate showed a high binding affinity on HT-29 colon cancer cell surfaces. In a biodistribution study, the tumor-to-blood ratio of the radioimmunoconjugate was 43 : 1 at 1 day post injection (p.i) in human colon cancer bearing mice. the anti-CD44 monoclonal antibody for the targeting of colon cancer was effectively radioimmunoconjugated with {sup 177}Lu. the in vitro high immunoactivity of this radioimmunoconjugate was determined by a cell binding assay. In addition, the antibody's tumor targeting ability was demonstrated with very high uptake in tumors. this radioimmunoconjugate is applicable to therapy in human colon cancer with highly expressed CD44.

  19. Improvement in the 111In-DTPA-TYR3-octreotide and 177Lu-DOTATYR3- octreotate production

    International Nuclear Information System (INIS)

    Souza, Adriano A.; Herrerias, Rosana; Pires, Jose A.; Alves, Geraldo P.; Fukumori, Neuza T.O.; Matsuda, Margareth M.N.; Almeida, Erika V.; Mengatti, Jair; Barboza, Marycel F. de

    2009-01-01

    Recent advances in receptor mediated-tumor imaging have resulted in the development of somatostatin analogues, the biomolecular basis for the clinical use of these compounds in nuclear medicine for diagnostic and peptide receptor radionuclide therapy (PRRT). PRRT is a very good therapeutic option for patients with metastatic neuroendocrine gastroenteropancreatic (GEP) tumour. Clinical studies with different sst-positives tumors proved advantages of [ 177 Lu-DOTA-Tyr 3 ]octreotate (DOTATATE) for therapy. The aim of this work is to establish and validate the labeling, the quality control procedures of DTPA-Tyr 3 -Octreotide (DTPA-Oct) and DOTA-Tyr 3 -Octreotate (DOTATATE) labeled with In-111 and Lu-177, respectively, for routine production at Radiopharmacy Directory (DIRF) Brazil. Labeling were performed in a 'glove-box' using 111 InCl 3 (Nordion) and in hot-cell with 177 LuCl 3 (IDB-Holland) at pH 4.5; using DTPA-Oct (Pichem) and DOTATATE (IDBHolland) at room temperature and at 82-85 deg C for 30 minutes, respectively. The radiochemical purity was determined by ITLC-SG in 0.1 mol L -1 sodium citrate, pH 5.5 and by Sep-Pak silica cartridge. Sterility was performed by the microbiology procedures and pyrogen tests by the 'in-vitro' Limulus test (LAL). The stability of both radiolabeled peptides was high even 72 hours under refrigeration. The radiochemical purities of the labeled compounds were confirmed by HPLC. Sterility and pyrogen tests were negative in all delivered vials. The efficient procedure to obtain 111 In-DTPA-Oct and 177 Lu-DOTATATE was confirmed in the first comparative clinical groups. The methods were validated and 46.287 GMBq of 111 In-DTPA-Oct and 1,193 GBq of 177 Lu-DOTATATE were distributed in 2008, to nuclear medicine services in Brazil. (author)

  20. Peptide receptor radionuclide therapy with 177Lu-DOTA-octreotate: dosimetry, nephrotoxicity, and the effect of hematological toxicity on survival.

    Science.gov (United States)

    Löser, Anastassia; Schwarzenböck, Sarah M; Heuschkel, Martin; Willenberg, Holger S; Krause, Bernd J; Kurth, Jens

    2018-03-01

    Peptide receptor radionuclide therapy (PRRT) with lutetium-177 (Lu)-DOTATATE is regarded as a safe treatment option with promising results for patients with neuroendocrine neoplasia (NEN). We aimed to study the absorbed organ and tumor doses, the renal and hematological toxicity as well as their mutual interaction. Another aim was the identification of adverse effects as possible predictors which may affect survival. A total of 30 (14 female and 16 male) patients with inoperable/metastatic NEN were treated with 7.4 GBq of Lu-DOTATATE. Occurrence of renal and hematological toxicity wasretrospectively studied. Morever, we examined the effects of hematological toxicity on survival after Lu-DOTATATE-PRRT. In 49 treatment cycles, the mean absorbed dose to the kidneys was 5.13±2.12, 4.49±2.49 Gy to the liver, and 14.44±8.97 Gy to the spleen, whereas tumor lesions absorbed a mean dose of 31.43±36.86 Gy. Comparing different localizations of metastases, no significant differences in absorbed dose were observed. Clinical response status revealed regressive disease in 47.6%, stable disease in 38.1%, and progressive disease in 14.3% of cases (n=21). Biochemically, 81.3% of patients showed reduced serotonin values (n=16; P<0.05) following Lu-DOTATATE-PRRT. No severe subacute renal or hematological toxicity occurred (one Common Terminology Criteria for Adverse Events-grade 3 for thrombocytopenia and another one for leukocytopenia). No statistically significant relation between baseline kidney function and post-therapeutic hematological changes was identified. The findings indicate that Lu-DOTATATE-PRRT is a safe and effective treatment method for patients with NEN. Moreover, these data strongly suggest that hematological parameters may affect survival so a further re-evaluation in prospective studies is warranted.

  1. An assessment tumor targeting ability of 177Lu labeled cyclic CCK analogue peptide by binding with cholecystokinin receptor

    Directory of Open Access Journals (Sweden)

    Eun-Ha Cho

    2016-07-01

    Full Text Available The cholecystokinin (CCK receptor is known as a receptor that is overexpressed in many human tumors. The present study was designed to investigate the targeting ability of cyclic CCK analogue in AR42J pancreatic cells. The CCK analogues, DOTA-K(glucose-Gly-Trp-Nle-Asp-Phe (DOTA-glucose-CCK and DOTA-Nle-cyclo(Glu-Trp-Nle-Asp-Phe-Lys-NH2 (DOTA-[Nle]-cCCK, were synthesized and radiolabeled with 177Lu, and competitive binding was evaluated. The binding appearance of synthesized peptide with AR42J cells was evaluated by confocal microscopy. And bio-distribution was performed in AR42J xenografted mice. Synthesized peptides were prepared by a solid phase synthesis method, and their purity was over 98%. DOTA is the chelating agent for 177Lu-labeling, in which the peptides were radiolabeled with 177Lu by a high radiolabeling yield. A competitive displacement of 125I-CCK8 on the AR42J cells revealed that the 50% inhibitory concentration value (IC50 was 12.3 nM of DOTA-glucose-CCK and 1.7 nM of DOTA-[Nle]-cCCK. Radio-labeled peptides were accumulated in AR42J tumor in vivo, and %ID/g of the tumor was 0.4 and 0.9 at 2 h p.i. It was concluded that 177Lu-DOTA-[Nle]-cCCK has higher binding affinity than 177Lu-DOTA-glucose-CCK and can be a potential candidate as a targeting modality for a CCK receptor over-expressing tumors.

  2. Measurements of Coster-Kronig enhancement factors for Yb, Lu, Os and Pt elements

    Energy Technology Data Exchange (ETDEWEB)

    Yilmaz, R. [Department of Physics, Faculty of Sciences and Arts, Yuezuencue Yil University, 65080 Van (Turkey)], E-mail: ryilmaz@yyu.edu.tr; Oz, E. [Department of Physics, Faculty of Sciences and Arts, 25240 Erzurum (Turkey); Tan, M. [Department of Physics, Faculty of Education, Gazi University, 06500 Ankara (Turkey); Durak, R. [Department of Physics, Faculty of Sciences and Arts, 25240 Erzurum (Turkey); Demirel, A.I. [Department of Physics, Faculty of Sciences and Arts, Yuezuencue Yil University, 65080 Van (Turkey); Sahin, Y. [Department of Physics, Faculty of Sciences and Arts, 25240 Erzurum (Turkey)

    2009-05-15

    In this work X-ray production cross-sections' measurements, L{sub {iota}}, L{sub {alpha}}, L{sub {beta}} and L{sub {gamma}}, of Yb, Lu, Os and Pt elements have been studied at energies in the range 9.572-14.384 keV and the effect of Coster-Kronig transitions on fluorescence cross-sections for L X-ray line has been obtained. From these studies absolute values of L X-ray cross-sections have been calculated with incorporation of the enhancement due to the Coster-Kronig effect. The experimental enhancement factors tend to be smaller than those predicted by theory.

  3. Diode-pumped passively mode-locked sub-picosecond Yb:LuAG ceramic laser

    International Nuclear Information System (INIS)

    Zhu Jiang-Feng; Liu Kai; Wang Jun-Li; Yang Yu; Wang Hui-Bo; Gao Zi-Ye; Jiang Li; Xie Teng-Fei; Chao-Yu Li; Pan Yu-Bai; Wei Zhi-Yi

    2017-01-01

    In this paper the laser activities of a diode-pumped Yb:LuAG ceramic which was prepared by the solid-state reactive sintering method were reported. The maximum output power was 1.86 W in the continuous wave (CW) laser operation, corresponding to a slope efficiency of 53.6%. The CW laser could be tuned from 1030 to 1096 nm by inserting a prism in the cavity. With the assist of a semiconductor saturable absorber mirror (SESAM), passive mode-locking was realized, delivering sub-picosecond pulses with 933 fs duration and an average power of 532 mW at a repetition rate of 90.35 MHz. (paper)

  4. Treatment of neuroendocrine tumors (NETs) expressing SMT 90Y and 177Lu

    International Nuclear Information System (INIS)

    Oliva González, Juan P.; Baum, Richard

    2016-01-01

    Neuroendocrine tumors (NETs) are a relatively rare and extremely heterogeneous group, essentially characterized by a different metabolism and endocrine histologically pattern. NETs are a challenge for physicians not only for diagnosis but also for early treatment. In addition to this, QT or RT treatments that require a high rate of cell proliferation to be effective, they are not in these tumors as slow growth. The primary treatment of NETs is surgery, either with a curative intent or tumor shrinkage. Peptide Receptors Radiotherapy (RTPR) consists of the administration for therapeutic purposes of Radiolabeled Synthetic Peptides that bind specifically and with high affinity to receptors of tumor cells. The RTPR of TNE with SMT analogues is effective for handling or metastizados inoperable patients. The Conference gives an accurate picture of the treatment of these tumors both 90 Y as 177 Lu. (author)

  5. Modernization of control system of the beam critical parameters at a lu-10 industrial electron accelerator

    International Nuclear Information System (INIS)

    Pomatsalyuk, R.I.; Uvarov, V.L.; Shevchenko, V.A.; Shlyakhov, I.N.

    2017-01-01

    Continuous control and monitoring of critical parameters of radiation processing of products is one of the requirements of the international standard ISO 11137. The current system to monitoring the parameters of radiation treatment of products at the LU-10 accelerator is being in operation for more than 15 years. The life-time of the mayor part of measuring modules is over, and those modules are no longer produced. Modernization of monitoring system with the use of the multi-functional USB modules, single-board mini-computers and EPICS control system (Experimental Physics and Industrial Control System) is considered. The architecture and software for a new monitoring system have been developed. Debugging and operation of the system in a test mode is performed

  6. Luminescence and scintillation properties of XPO4:Nd3+ (X = Y, Lu, Sc, La) crystals

    Science.gov (United States)

    Makowski, Michał; Witkowski, Marcin E.; Drozdowski, Winicjusz; Wojtowicz, Andrzej J.; Wisniewski, Krzysztof; Boatner, Lynn A.

    2018-05-01

    Due to their very fast short-wavelength emission, neodymium-doped materials are a subject of current interest as potential scintillators. Although the initial reports regarding neodymium-doped orthophosphates (in crystalline form) and their scintillation properties appeared almost twenty years ago, they remain an interesting class of materials since there is no in-depth understanding of their fundamental scintillation mechanism. In the present research, we focus on the crystalline systems: XPO4:Nd3+, where X = Y, Lu, La, Sc. The pulse height, optical absorption, radioluminescence and photoluminescence spectra were investigated and are reported here for various temperatures from 10 to 350 K. Additionally, results of both low and high temperature thermoluminescence measurements are reported in this communication.

  7. Applying LU Decomposition of Matrices to Design Anonymity Bilateral Remote User Authentication Scheme

    Directory of Open Access Journals (Sweden)

    Xiong Li

    2013-01-01

    Full Text Available We apply LU decomposition of matrices to present an anonymous bilateral authentication scheme. This paper aims at improving security and providing more excellent performances for remote user authentication scheme. The proposed scheme can provide bilateral authentication and session key agreement, can quickly check the validity of the input password, and can really protect the user anonymity. The security of the proposed scheme is based on the discrete logarithm problem (DLP, Diffie-Hellman problem (DHP, and the one-way hash function. It can resist various attacks such as insider attack, impersonation attack, server spoofing attack, and stolen smart card attack. Moreover, the presented scheme is computationally efficient for real-life implementation.

  8. A work criterion for plastic collapse

    International Nuclear Information System (INIS)

    Muscat, Martin; Mackenzie, Donald; Hamilton, Robert

    2003-01-01

    A new criterion for evaluating limit and plastic loads in pressure vessel design by analysis is presented. The proposed criterion is based on the plastic work dissipated in the structure as loading progresses and may be used for structures subject to a single load or a combination of multiple loads. Example analyses show that limit and plastic loads given by the plastic work criterion are robust and consistent. The limit and plastic loads are determined purely by the inelastic response of the structure and are not influenced by the initial elastic response: a problem with some established plastic criteria

  9. The in vivo disposition and in vitro transmembrane transport of two model radiometabolites of DOTA-conjugated receptor-specific peptides labelled with (177) Lu.

    Science.gov (United States)

    Volková, Marie; Mandíková, Jana; Bárta, Pavel; Navrátilová, Lucie; Lázníčková, Alice; Trejtnar, František

    2015-01-01

    In vivo metabolism of the radiolabelled receptor-specific peptides has been described; however, information regarding the pharmacokinetic behaviour of the degradation products within the body is very scarce. The present study was designed to obtain new knowledge on the disposition and elimination of low-molecular radiometabolites of receptor-specific peptides in the organism and to reveal the potential involvement of selected membrane transport mechanisms in the cellular uptake of radiometabolites, especially in the kidney. The study compared pharmacokinetics of two radiometabolites: a final metabolite of somatostatin analogues, (177)Lu-DOTA-DPhe, and a tripeptide metabolite of (177)Lu-DOTA-minigastrin 11, (177)Lu-DOTA-DGlu-Ala-Tyr. Their pharmacokinetics was compared with that of respective parent (177)Lu-radiopeptide. Both radiometabolites exhibited relative rapid clearing from most body tissues in rats in vivo along with predominant renal excretion. The long-term renal retention of the smaller radiometabolite (177)Lu-DOTA-DPhe was lower than that of (177)Lu-DOTA-DGlu-Ala-Tyr. An uptake of (177)Lu-DOTA-DPhe by human renal influx transporter organic cation transporter 2 was found in vitro in a cellular model. The study brings the first experimental data on the in vivo pharmacokinetics of radiometabolites of receptor-specific somatostatin and gastrin analogues. The found results may indicate a negative correlation between the degree of decomposition of the parent peptide chain and the renal retention of the metabolite. Copyright © 2015 John Wiley & Sons, Ltd.

  10. Cross Section Measurements for Some Elements Suited as Thermal Spectrum indicators: Cd, Sm, Gd and Lu

    Energy Technology Data Exchange (ETDEWEB)

    Sokolowski, E; Pekarek, H; Jonsson, E

    1964-05-15

    The effective cross sections of Cd, Sm, Gd and Lu have been measured by the oscillator technique in the spectrum of the central channel of the Swedish reactor R1. For Cd, Sm and Gd the 2200 m/s cross sections were deduced on the basis of Westcott's g and s factors. The values obtained were generally in agreement with other recent values obtained by integral methods, although a systematic trend indicated that the value T{sub n} - T{sub m} = 29 {+-} 10 deg C for the neutron spectrum, measured with a fast chopper, was slightly too high. A new value of T{sub n} - T{sub m} = 22.5 {+-} 3.5 deg C was deduced and new 2200 m/s cross sections were obtained by iteration. For natural Lu, the energy dependence of the cross section is not well known. Certain assumptions about the cross section function led to unreasonably high values for the 2200 m/s cross section. Complementary differential measurements of the cross sections of Cd, Sm and Gd were made with the Rl fast chopper. For Cd and Sm the 2200 m/s cross section thus obtained agreed within experimental error with those obtained from the integral measurements. For Gd, the chopper measured value was higher, confirming earlier findings and indicating that the Westcott g factor for Gd is too high. Cd: Integral meas. : {sigma}(2200) = 2,390 {+-} 45 b; Differential meas. : {sigma}(2200) = 2,445 {+-} 25 b; Sm: Integral meas. : {sigma}(2200) = 5,880 {+-} 90 b; Differential meas. : {sigma}(2200) = 5,740 {+-} 150 b; Gd: Integral meas. : {sigma}(2200) = 46,470 {+-} 550 b; Differential meas. : {sigma}(2200) = 47,900 {+-} 700 b.

  11. Cross Section Measurements for Some Elements Suited as Thermal Spectrum indicators: Cd, Sm, Gd and Lu

    Energy Technology Data Exchange (ETDEWEB)

    Sokolowski, E.; Pekarek, H.; Jonsson, E.

    1964-05-15

    The effective cross sections of Cd, Sm, Gd and Lu have been measured by the oscillator technique in the spectrum of the central channel of the Swedish reactor R1. For Cd, Sm and Gd the 2200 m/s cross sections were deduced on the basis of Westcott's g and s factors. The values obtained were generally in agreement with other recent values obtained by integral methods, although a systematic trend indicated that the value T{sub n} - T{sub m} = 29 {+-} 10 deg C for the neutron spectrum, measured with a fast chopper, was slightly too high. A new value of T{sub n} - T{sub m} = 22.5 {+-} 3.5 deg C was deduced and new 2200 m/s cross sections were obtained by iteration. For natural Lu, the energy dependence of the cross section is not well known. Certain assumptions about the cross section function led to unreasonably high values for the 2200 m/s cross section. Complementary differential measurements of the cross sections of Cd, Sm and Gd were made with the Rl fast chopper. For Cd and Sm the 2200 m/s cross section thus obtained agreed within experimental error with those obtained from the integral measurements. For Gd, the chopper measured value was higher, confirming earlier findings and indicating that the Westcott g factor for Gd is too high. Cd: Integral meas. : {sigma}(2200) = 2,390 {+-} 45 b; Differential meas. : {sigma}(2200) = 2,445 {+-} 25 b; Sm: Integral meas. : {sigma}(2200) = 5,880 {+-} 90 b; Differential meas. : {sigma}(2200) = 5,740 {+-} 150 b; Gd: Integral meas. : {sigma}(2200) = 46,470 {+-} 550 b; Differential meas. : {sigma}(2200) = 47,900 {+-} 700 b.

  12. High performance matrix inversion based on LU factorization for multicore architectures

    KAUST Repository

    Dongarra, Jack

    2011-01-01

    The goal of this paper is to present an efficient implementation of an explicit matrix inversion of general square matrices on multicore computer architecture. The inversion procedure is split into four steps: 1) computing the LU factorization, 2) inverting the upper triangular U factor, 3) solving a linear system, whose solution yields inverse of the original matrix and 4) applying backward column pivoting on the inverted matrix. Using a tile data layout, which represents the matrix in the system memory with an optimized cache-aware format, the computation of the four steps is decomposed into computational tasks. A directed acyclic graph is generated on the fly which represents the program data flow. Its nodes represent tasks and edges the data dependencies between them. Previous implementations of matrix inversions, available in the state-of-the-art numerical libraries, are suffer from unnecessary synchronization points, which are non-existent in our implementation in order to fully exploit the parallelism of the underlying hardware. Our algorithmic approach allows to remove these bottlenecks and to execute the tasks with loose synchronization. A runtime environment system called QUARK is necessary to dynamically schedule our numerical kernels on the available processing units. The reported results from our LU-based matrix inversion implementation significantly outperform the state-of-the-art numerical libraries such as LAPACK (5x), MKL (5x) and ScaLAPACK (2.5x) on a contemporary AMD platform with four sockets and the total of 48 cores for a matrix of size 24000. A power consumption analysis shows that our high performance implementation is also energy efficient and substantially consumes less power than its competitors. © 2011 ACM.

  13. Body dysmorphia and plastic surgery.

    Science.gov (United States)

    Kyle, Allison

    2012-01-01

    Body dysmorphic disorder is a mental disorder characterized by a preoccupation with some aspect of one's appearance. In cosmetic surgery, this preoccupation can be overlooked by practitioners resulting in a discrepancy between expected and realistic outcome. Identifying the characteristics of this disorder may be crucial to the practitioner-patient relationship in the plastic surgery setting.

  14. Ways of Viewing Pictorial Plasticity

    NARCIS (Netherlands)

    Wijntjes, M.W.A.

    2017-01-01

    The plastic effect is historically used to denote various forms of stereopsis. The vivid impression of depth often associated with binocular stereopsis can also be achieved in other ways, for example, using a synopter. Accounts of this go back over a hundred years. These ways of viewing all aim

  15. Ways of Viewing Pictorial Plasticity

    Directory of Open Access Journals (Sweden)

    Maarten W. A. Wijntjes

    2017-03-01

    Full Text Available The plastic effect is historically used to denote various forms of stereopsis. The vivid impression of depth often associated with binocular stereopsis can also be achieved in other ways, for example, using a synopter. Accounts of this go back over a hundred years. These ways of viewing all aim to diminish sensorial evidence that the picture is physically flat. Although various viewing modes have been proposed in the literature, their effects have never been compared. In the current study, we compared three viewing modes: monocular blur, synoptic viewing, and free viewing (using a placebo synopter. By designing a physical embodiment that was indistinguishable for the three experimental conditions, we kept observers naïve with respect to the differences between them; 197 observers participated in an experiment where the three viewing modes were compared by performing a rating task. Results indicate that synoptic viewing causes the largest plastic effect. Monocular blur scores lower than synoptic viewing but is still rated significantly higher than the baseline conditions. The results strengthen the idea that synoptic viewing is not due to a placebo effect. Furthermore, monocular blur has been verified for the first time as a way of experiencing the plastic effect, although the effect is smaller than synoptic viewing. We discuss the results with respect to the theoretical basis for the plastic effect. We show that current theories are not described with sufficient details to explain the differences we found.

  16. Ways of Viewing Pictorial Plasticity.

    Science.gov (United States)

    Wijntjes, Maarten W A

    2017-01-01

    The plastic effect is historically used to denote various forms of stereopsis. The vivid impression of depth often associated with binocular stereopsis can also be achieved in other ways, for example, using a synopter. Accounts of this go back over a hundred years. These ways of viewing all aim to diminish sensorial evidence that the picture is physically flat. Although various viewing modes have been proposed in the literature, their effects have never been compared. In the current study, we compared three viewing modes: monocular blur, synoptic viewing, and free viewing (using a placebo synopter). By designing a physical embodiment that was indistinguishable for the three experimental conditions, we kept observers naïve with respect to the differences between them; 197 observers participated in an experiment where the three viewing modes were compared by performing a rating task. Results indicate that synoptic viewing causes the largest plastic effect. Monocular blur scores lower than synoptic viewing but is still rated significantly higher than the baseline conditions. The results strengthen the idea that synoptic viewing is not due to a placebo effect. Furthermore, monocular blur has been verified for the first time as a way of experiencing the plastic effect, although the effect is smaller than synoptic viewing. We discuss the results with respect to the theoretical basis for the plastic effect. We show that current theories are not described with sufficient details to explain the differences we found.

  17. Electron beam micromachining of plastics

    Czech Academy of Sciences Publication Activity Database

    Dupák, Libor

    2014-01-01

    Roč. 49, 5-6 (2014), s. 310-314 ISSN 0861-4717 R&D Projects: GA MŠk(CZ) LO1212; GA MŠk ED0017/01/01; GA MŠk EE.2.3.20.0103 Institutional support: RVO:68081731 Keywords : micromachining of plastics * Electron beam Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering

  18. Field based plastic contamination sensing

    Science.gov (United States)

    The United States has a long-held reputation of being a dependable source of high quality, contaminant-free cotton. Recently, increased incidence of plastic contamination from sources such as shopping bags, vegetable mulch, surface irrigation tubing, and module covers has threatened the reputation o...

  19. Recycling of plastics in Germany

    International Nuclear Information System (INIS)

    Thienen, N. von; Patel, M.

    1999-01-01

    This article deals with the waste management of post-consumer plastics in Germany and its potential to save fossil fuels and reduce CO 2 emissions. Since most experience is available for packaging, the paper first gives an overview of the legislative background and the material flows for this sector. Then recycling and recovery processes for plastics waste from all sectors are assessed in terms of their contribution to energy saving and CO 2 abatement. Practically all the options studied show a better performance than waste treatment in an average incinerator which has been chosen as the reference case. High ecological benefits can be achieved by mechanical recycling if virgin polymers are substituted. The paper then presents different scenarios for managing plastic waste in Germany in 1995: considerable savings can be made by strongly enhancing the efficiency of waste incinerators. Under these conditions the distribution of plastics waste among mechanical recycling, feedstock recycling and energy recovery has a comparatively mall impact on the overall results. The maximum savings amount to 74 PJ of energy, i.e, 9% of the chemical sector energy demand in 1995 and 7.0 Mt CO 2 , representing 13% of the sector's emissions. The assessment does not support a general recommendation of energy recovery due to the large difference between the German average and the best available municipal waste-to-energy facilities and also due to new technological developments in the field of mechanical recycling

  20. Transformation plasticity and hot pressing

    International Nuclear Information System (INIS)

    Chaklader, A.C.D.

    1975-01-01

    The transformation plasticity during the phase transition of quartz to cristobalite, monoclinic reversible tetragonal of zirconia, metakaolin to a spinel phase, and brucite to periclase was investigated by studying their compaction characteristics. Viscous flow was found to be the predominant mechanism of mass transport (after an initial particle rearrangement stage) in the case of quartz to cristobalite phase change where the transformation was associated with the formation of an intermediate amorphous silica phase. The results on the monoclinic reversible tetragonal transformation of zirconia indicated that it is most likely controlled by internal strain induced by the stress associated with the volume change (ΔV/V) and the flow stress of the weaker phase. Particle movement and deformation of the weaker phase (possibly tetragonal) may be the manifestation of this plasticity. The plasticity in the case of metakaolin to a spinel phase appeared to start before the exothermic reaction (generally encountered in a dta plot) and may be diffusion controlled. The plasticity encountered during brucite to periclase transformation may be the combined effect of disintegration of precursor particles, vapor-phase lubrication and some deformability of freshly formed very fine MgO particles

  1. Third-line treatment and 177Lu-PSMA radioligand therapy of metastatic castration-resistant prostate cancer: a systematic review

    International Nuclear Information System (INIS)

    Edler von Eyben, Finn; Roviello, Giandomenico; Kiljunen, Timo; Kairemo, Kalevi; Joensuu, Timo; Uprimny, Christian; Virgolini, Irene

    2018-01-01

    There is a controversy as to the relative efficacy of 177 Lu prostate specific membrane antigen (PSMA) radioligand therapy (RLT) and third-line treatment for patients with metastatic castration-resistant prostate cancer (mCRPC). The aim of our systematic review was to elucidate whether 177 Lu-PSMA RLT and third-line treatment have similar effects and adverse effects (PROSPERO ID CRD42017067743). The review followed Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Searches in Pubmed and Embase selected articles up to September 2017. A search in ClinicalTrials.gov indicated ongoing studies. The meta-analysis used the random-effects model. Twelve studies including 669 patients reported 177 Lu-PSMA RLT. Overall, 43% of the patients had a maximum decline of PSA of ≥50% following treatment with 177 Lu-PSMA RLT. The treatment with 177 Lu-PSMA-617 and 177 Lu-PSMA for imaging and therapy (I and T) had mainly transient adverse effects. Sixteen studies including 1338 patients reported third-line treatment. Overall, 21% of the patients had a best decline of PSA of ≥50% following third-line treatment. After third-line treatment with enzalutamide and cabazitaxel, adverse effects caused discontinuation of treatment for 10% to 23% of the patients. 177 Lu-PSMA RLT gave a best PSA decline ≥50% more often than third-line treatment (mean 44% versus 22%, p = 0.0002, t test). 177 Lu-PSMA RLT gave objective remission more often than third-line treatment (overall 31 of 109 patients versus 43 of 275 patients, p = 0.004, χ 2 test). Median survival was longer after 177 Lu-PSMA RLT than after third-line treatment, but the difference was not statistically significant (mean 14 months versus 12 months, p = 0.32, t test). Adverse effects caused discontinuation of treatment more often for third-line treatment than for 177 Lu-PSMA RLT (22 of 66 patients versus 0 of 469 patients, p < 0.001, χ 2 test). As for patients with mCRPC, treatment with 177 Lu

  2. Third-line treatment and {sup 177}Lu-PSMA radioligand therapy of metastatic castration-resistant prostate cancer: a systematic review

    Energy Technology Data Exchange (ETDEWEB)

    Edler von Eyben, Finn [Center of Tobacco Control Research, Odense (Denmark); Roviello, Giandomenico [San Donato Hospital, Department of Oncology, Medical Oncology Unit, Arezzo (Italy); University of Trieste, Department Medical, Surgery, and Health Sciences, Trieste (Italy); Kiljunen, Timo; Kairemo, Kalevi; Joensuu, Timo [Docrates Cancer Center, Helsinki (Finland); Uprimny, Christian; Virgolini, Irene [University Hospital Innsbruck, Department of Nuclear Medicine, Innsbruck (Austria)

    2018-03-15

    There is a controversy as to the relative efficacy of {sup 177}Lu prostate specific membrane antigen (PSMA) radioligand therapy (RLT) and third-line treatment for patients with metastatic castration-resistant prostate cancer (mCRPC). The aim of our systematic review was to elucidate whether {sup 177}Lu-PSMA RLT and third-line treatment have similar effects and adverse effects (PROSPERO ID CRD42017067743). The review followed Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Searches in Pubmed and Embase selected articles up to September 2017. A search in ClinicalTrials.gov indicated ongoing studies. The meta-analysis used the random-effects model. Twelve studies including 669 patients reported {sup 177}Lu-PSMA RLT. Overall, 43% of the patients had a maximum decline of PSA of ≥50% following treatment with {sup 177}Lu-PSMA RLT. The treatment with {sup 177}Lu-PSMA-617 and {sup 177}Lu-PSMA for imaging and therapy (I and T) had mainly transient adverse effects. Sixteen studies including 1338 patients reported third-line treatment. Overall, 21% of the patients had a best decline of PSA of ≥50% following third-line treatment. After third-line treatment with enzalutamide and cabazitaxel, adverse effects caused discontinuation of treatment for 10% to 23% of the patients. {sup 177}Lu-PSMA RLT gave a best PSA decline ≥50% more often than third-line treatment (mean 44% versus 22%, p = 0.0002, t test). {sup 177}Lu-PSMA RLT gave objective remission more often than third-line treatment (overall 31 of 109 patients versus 43 of 275 patients, p = 0.004, χ{sup 2} test). Median survival was longer after {sup 177}Lu-PSMA RLT than after third-line treatment, but the difference was not statistically significant (mean 14 months versus 12 months, p = 0.32, t test). Adverse effects caused discontinuation of treatment more often for third-line treatment than for {sup 177}Lu-PSMA RLT (22 of 66 patients versus 0 of 469 patients, p < 0.001, χ{sup 2

  3. Plastics and beaches: A degrading relationship

    International Nuclear Information System (INIS)

    Corcoran, Patricia L.; Biesinger, Mark C.; Grifi, Meriem

    2009-01-01

    Plastic debris in Earth's oceans presents a serious environmental issue because breakdown by chemical weathering and mechanical erosion is minimal at sea. Following deposition on beaches, plastic materials are exposed to UV radiation and physical processes controlled by wind, current, wave and tide action. Plastic particles from Kauai's beaches were sampled to determine relationships between composition, surface textures, and plastics degradation. SEM images indicated that beach plastics feature both mechanically eroded and chemically weathered surface textures. Granular oxidation textures were concentrated along mechanically weakened fractures and along the margins of the more rounded plastic particles. Particles with oxidation textures also produced the most intense peaks in the lower wavenumber region of FTIR spectra. The textural results suggest that plastic debris is particularly conducive to both chemical and mechanical breakdown in beach environments, which cannot be said for plastics in other natural settings on Earth

  4. Toward Modeling Limited Plasticity in Ceramic Materials

    National Research Council Canada - National Science Library

    Grinfeld, Michael; Schoenfeld, Scott E; Wright, Tim W

    2008-01-01

    The characteristic features of many armor-related ceramic materials are the anisotropy on the micro-scale level and the very limited, though non-vanishing, plasticity due to limited number of the planes for plastic slip...

  5. Antireflection coatings on plastics deposited by plasma ...

    Indian Academy of Sciences (India)

    In the ophthalmic industry, plastic lenses are rapidly displacing glass lenses ... Moreover, the plasma polymerization process allows deposition of optical films at room temperature, essential for plastics. ... Bulletin of Materials Science | News.

  6. Mechanical behaviour of nanoparticles: Elasticity and plastic ...

    Indian Academy of Sciences (India)

    2015-06-03

    Jun 3, 2015 ... Mechanical behaviour of nanoparticles: Elasticity and plastic deformation mechanisms ... The main results in terms of elasticity and plastic deformation mechanisms are then reported ... Pramana – Journal of Physics | News.

  7. Production and Stability Study of High Activity 177Lu-Substance P as a Radiopharmaceutical for Malignant Tumors Treatment

    International Nuclear Information System (INIS)

    Araujo, E.B. de; Lima, C.M. de; Pujatti, P.B.; Mengatti, J.

    2009-01-01

    In recent years, a high number of new developments in target therapies have emerged and the presence of peptide receptors and transporters at the cell membrane of several tumors constitutes the basis of the clinical use of specific radiolabeled ligands, such as Substance P (SP). SP is an 11-amino acid neuropeptide member of the family of tachykinins, characterized by the C-terminal sequence Phe-X- Gly-Leu-Met-NH 2 . It has been well established that SP plays an important role in modulating pain transmission from peripheral and central primary afferents and this peptide may be also involved in the pathogenesis of inflammatory diseases. SP receptors are also found in brain, lymphoid tissues, vessels, gut smooth muscle, airway glands and bronchiolar walls. In receptor autoradiography of tumor specimens ex vivo, SP receptors were found on glioblastoma, medullary thyroid cancer, non- small cell lung cancer and carcinoma of pancreas, but the incidence is low in the last two. The introduction of radiolabeled SP for peptide receptor radiotherapy can be an alternative to treat these tumors by radionuclide therapy or loco-regional instillation. Several radioisotopes have been applied to radiolabel peptides for radionuclide therapy and 6.7 day half-life 177 Lu has emerged as a promising β- emitter for this purpose. The energy (497 keV) and mean range (670 μm) of lutetium-177 β particles are ideal for small tumors and micro-metastatic disease treatment. Because it also emits γ rays (208 keV, 11% abundance), imaging of 177 Lu-labeled endoradiotherapeutic agents is also possible. The goal of the present work was to determine the best radiolabeling conditions and the stability of SP complexed to DOTA chelator, using 177 Lu as radionuclide. The optimized condition was applied to produce a high activity and stable 177Lu-DOTA-SP, as a radiopharmaceutical for malignant tumors treatment. Substance P was radiolabeled at different conditions in order to determine the best

  8. Recycling plastic bottles in a creative way

    OpenAIRE

    Pavlin, Suzana

    2016-01-01

    Beside other plastic products, plastic bottles represent a true environmental disaster in the last few years. We assume that hardly anyone asks what happens after they drink that last drop of water out of it. Just like most municipal waste, a plastic bottle can be reused, recycled, burned or deposited into landfill. When the Environment Protection Act is not respected, plastic bottle ends up in the nature, very often in the sea, where it decomposes very slowly and has negative influence on th...

  9. Plastic Accumulation in the Mediterranean Sea

    OpenAIRE

    C?zar, Andr?s; Sanz-Mart?n, Marina; Mart?, Elisa; Gonz?lez-Gordillo, J. Ignacio; Ubeda, B?rbara; G?lvez, Jos? ?.; Irigoien, Xabier; Duarte, Carlos M.

    2015-01-01

    Copyright: © 2015 Cózar et al. Concentrations of floating plastic were measured throughout the Mediterranean Sea to assess whether this basin can be regarded as a great accumulation region of plastic debris. We found that the average density of plastic (1 item per 4 m2), as well as its frequency of occurrence (100% of the sites sampled), are comparable to the accumulation zones described for the five subtropical ocean gyres. Plastic debris in the Mediterranean surface waters was dominated by ...

  10. ARE PLASTIC GROCERY BAGS SACKING THE ENVIRONMENT?

    Directory of Open Access Journals (Sweden)

    Mangal Gogte

    2009-12-01

    Full Text Available This paper is oriented on analysis impacts of plastic bags on environment. In this paper is analyzed did plastic bags are so harmful, and what are the main ingredients of it. One part of this paper is oriented on effects of plastic bags and management of their usage. There is also made comparative analysis between impacts of plastic and paper bags on environment.

  11. PLASTIC ANALYSIS OF STEEL FRAME STRUCTURE

    Directory of Open Access Journals (Sweden)

    M. Rogac

    2013-05-01

    Full Text Available This paper presents the plastic analysis of steel frame structure loaded by gravity loads. By applying the cinematic theorem of ultimate analysis, the ultimate load for the case of elastic - ideally plastic material is calculated. The identical structure was treated in the computer program SAP2000 where the zone of material reinforcement in the plastic area was covered. Keywords: Steel frame structure, plastic analysis, ultimate gravity load, material reinforcement.

  12. Functional nanostructures on injection molded plastic

    DEFF Research Database (Denmark)

    Johansson, Alicia Charlotte; Søgaard, Emil; Andersen, Nis Korsgaard

    Nanotechnology can be used to make inexpensive plastic parts with functional surfaces. The plastic parts can be molded using a standard injection molding process. The nanostructures are directly transferred from the surface of the molding tool to the surface of the molded plastic part during...

  13. 7 CFR 58.326 - Plastic cream.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Plastic cream. 58.326 Section 58.326 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards... Material § 58.326 Plastic cream. To produce plastic cream eligible for official certification, the quality...

  14. Use of Plastic Mulch for Vegetable Production

    OpenAIRE

    Maughan, Tiffany; Drost, Dan

    2016-01-01

    Plastic mulches are used commercially for both vegetables and small fruit crops. Vegetable crops well suited for production with plastic mulch are typically high value row crops. This fact sheet describes the advantages, disadvantages, installation, and planting considerations. It includes sources for plastic and equipment.

  15. The evolution of age-dependent plasticity

    NARCIS (Netherlands)

    Fischer, Barbara; van Doorn, G. Sander; Dieckmann, Ulf; Taborsky, Barbara

    2014-01-01

    When organisms encounter environments that are heterogeneous in time, phenotypic plasticity is often favored by selection. The degree of such plasticity can vary during an organism''s lifetime, but the factors promoting differential plastic responses at different ages or life stages remain poorly

  16. Plastic Debris Is a Human Health Issue

    NARCIS (Netherlands)

    Vethaak, A.D.; Leslie, H.A.

    2016-01-01

    The global threat of highly persistent plastic waste accumulating and fragmenting in the world’s oceans, inland waters and terrestrial environments is becoming increasingly evident.1−3 Humans are being exposed to both plastic particles and chemical additives being released from the plastic debris of

  17. Structural, electronic, optical and thermodynamic properties of cubic REGa{sub 3} (RE = Sc or Lu) compounds: Ab initio study

    Energy Technology Data Exchange (ETDEWEB)

    Murtaza, G., E-mail: murtaza@icp.edu.pk [Materials Modeling Laboratory, Department of Physics, Islamia College Peshawar (Pakistan); Gupta, S.K. [Department of Physics, Michigan Technological University, Houghton, MI 49931 (United States); Seddik, T. [Laboratoire de Physique Quantique et de Modélisation Mathématique, Université de Mascara, 29000 Mascara (Algeria); Khenata, R., E-mail: khenata_rabah@yahoo.fr [Laboratoire de Physique Quantique et de Modélisation Mathématique, Université de Mascara, 29000 Mascara (Algeria); Alahmed, Z.A. [Department of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451 (Saudi Arabia); Ahmed, R. [Department of Physics, Faculty of Science, Universiti Teknologi Malaysia, UTM Skudai, 81310 Johor (Malaysia); Khachai, H. [Physics Department, Djillali Liabes University of Sidi Bel-Abbes (Algeria); Jha, P.K. [Department of Physics, Maharaja Krishnakumarsinhji Bhavnagar University, Bhavnagar 364001 (India); Bin Omran, S. [Department of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451 (Saudi Arabia)

    2014-06-01

    Highlights: • REGa{sub 3} (RE = Sc or Lu) compounds are mechanical stabile. • Both ScGa{sub 3} and LuGa{sub 3} exhibit metallic behavior just like other REGa{sub 3} compounds. • Melting temperature T{sub m} (K) for ScGa{sub 3} and LuGa{sub 3} are 1244.2 and 1143.8. • High absorption observed in the visible energy region. • The present study would be helpful for future experimental/theoretical explorations. - Abstract: Structural, elastic, optoelectronic and thermodynamic properties of REGa{sub 3} (RE = Sc and Lu) compounds have been studied self consistently by employing state of the art full potential (FP) linearized (L) approach of augmented plane wave (APW) plus local orbitals method. Calculations were executed at the level of Perdew–Burke and Ernzerhof (PBE) parameterized generalized gradient approximation (GGA) for exchange correlation functional in addition to modified Becke–Johnson (mBJ) potential. Our obtained results of lattice parameters show reasonable agreement to the previously reported experimental and other theoretical studies. Analysis of the calculated band structure of ScGa{sub 3} and LuGa{sub 3} compounds demonstrates their metallic character. Moreover, a positive value of calculated Cauchy pressure, in addition to reflecting their ductile nature, endorses their metallic character as well. To understand optical behavior calculations related to the important optical parameters; real and imaginary parts of the dielectric function, reflectivity R(ω), refractive index n(ω) and electron energy-loss function L(ω) have also been performed. In the present work, thermodynamically properties are also investigated by employing lattice vibrations integrated in quasi harmonic Debye model. Obtained results of volume, heat capacity and Debye temperature as a function of temperature for both compounds, at different values of pressure, are found to be consistent. The calculated value of melting temperature for both compounds (ScGa{sub 3} and Lu

  18. Bandgap engineering of the Lu{sub x}Y{sub 1−x}PO{sub 4} mixed crystals

    Energy Technology Data Exchange (ETDEWEB)

    Levushkina, V.S., E-mail: viktoriia.levushkina@ut.ee [Institute of Physics, University of Tartu, Ravila 14c, 50411 Tartu (Estonia); Physics Faculty, Moscow State University, Leninskiye Gory 1-2, 11991 Moscow (Russian Federation); Spassky, D.A. [Institute of Physics, University of Tartu, Ravila 14c, 50411 Tartu (Estonia); Skobeltsyn Institute of Nuclear Physics, Moscow State University, Leninskiye Gory 1-2, 11991 Moscow (Russian Federation); Aleksanyan, E.M. [Institute of Physics, University of Tartu, Ravila 14c, 50411 Tartu (Estonia); A. Alikhanyan National Science Laboratory, Yerevan Physics Institute, Alikhanyan Yeghbayrneri St. 2, 0036 Yerevan (Armenia); Brik, M.G. [Institute of Physics, University of Tartu, Ravila 14c, 50411 Tartu (Estonia); College of Sciences, Chongqing University of Posts and Telecommunications, 400065 Chongqing (China); Institute of Physics, Jan Dlugosz University, Armii Krajowej 13/15, PL-42200 Czestochowa (Poland); Institute of Physics, Polish Academy of Sciences, Al. Lotników 32/46, 02-668 Warsaw (Poland); Tretyakova, M.S.; Zadneprovski, B.I. [Central Research and Development Institute of Chemistry and Mechanics, Nagatinskaya St. 16a, 115487 Moscow (Russian Federation); Belsky, A.N. [Institute of Light and Matter, CNRS, University Lyon1, 69622 Villeurbanne (France)

    2016-03-15

    Bandgap modification of the Lu{sub x}Y{sub 1−x}PO{sub 4} mixed crystals has been studied by thermostimulated luminescence (TSL) and ab-initio calculation methods. Doping of Lu{sub x}Y{sub 1−x}PO{sub 4} with Ce{sup 3+} allowed to follow up the changes of electron traps depth, caused by the modification of the bottom of conduction band. The observed gradual shift of the most intensive TSL peaks to higher temperatures with increase of x value was connected with the high-energy shift of the conduction band bottom. According to the band structure calculations the bottom of the conduction band is formed by the 5d and 4d states of Lu and Y, respectively. Therefore, substitution of one cation by another is responsible for the observed variation of the electronic and optical properties. Doping with Eu{sup 3+} was used to study the modification of the hole traps and the top of the valence band in Lu{sub x}Y{sub 1−x}PO{sub 4}. The independence of the TSL peaks position on x value in Lu{sub x}Y{sub 1−x}PO{sub 4}:Eu{sup 3+} allows to conclude that the top of the valence band is negligibly affected by the cation substitution. According to the band structure calculations the top of the valence band is formed by the O 2p electronic states, which are not affected by the cation substitution. The resulting increase of the bandgap with x value is confirmed by the data of ab-initio calculations. - Highlights: • Band structure modification with x in Lu{sub x}Y{sub 1−x}PO{sub 4}:RE{sup 3+} (RE=Ce, Eu) is studied. • Depth of electron traps is affected by the bandgap modification. • Increase of bandgap with x is due to the shift of conduction band bottom.

  19. Plastic deformation and contact area of an elastic-plastic contact of ellipsoid bodies after unloading

    NARCIS (Netherlands)

    Jamari, Jamari; Schipper, Dirk J.

    2007-01-01

    This paper presents theoretical and experimental results of the residual or plastic deformation and the plastic contact area of an elastic–plastic contact of ellipsoid bodies after unloading. There are three regime responses of the deformation and contact area: elastic, elastic–plastic and fully

  20. Evaluation of the therapeutic efficacy and radiotoxicity of the conjugates 177Lu-DOTA-E-c(RGDfK)2 and 177Lu-DOTA-GGC-AuNP-c[RGDfk(C)] in a murine model and their relationship with the inhibition of the angiogenic factors VEGF and HIF-1α

    International Nuclear Information System (INIS)

    Vilchis J, A.

    2013-01-01

    Molecular targeting therapy has become a relevant therapeutic strategy for cancer. The principle that peptide receptors can be used successfully for in vivo targeting of human cancers has been proven, and radiolabeled peptides have been demonstrated to be effective in patients with malignant tumors. Peptides based on the cyclic Arg-Gly-Asp (RGD) sequence have been designed to antagonize the function of α(v)β(3) integrin, thereby inhibiting angio genesis. The conjugation of RGD peptides to radiolabeled gold nanoparticles (AuNP) produces biocompatible and stable m ultimeric systems with target-specific molecular recognition. The aim of this research was to evaluate the therapeutic response of 177 Lu-AuNP-RGD in athymic mice bearing α(v)β(3)-integrin-positive C6 gliomas and compare with that of 177 Lu-AuNP or 177 Lu-RGD. The radiation absorbed dose, metabolic activity (SUV, [18F]fluor-deoxy-glucose-micro PET/CT), renal radiotoxicity, renal and tumoral histological characteristics as well as tumoral VEGF and HIF-1? gene expression (by realtime polymerase chain reaction) following treatment with 177 Lu-AuNP-RGD, 177 Lu-AuNP or 177 Lu-RGD were assessed. Of the radiopharmaceuticals evaluated, 177 Lu-AuNP-RGD delivered the highest tumor radiation absorbed dose (63.8 ± 7.9 Gy) vs other treatments. These results correlated with the observed therapeutic response, in which 177 Lu-AuNP-RGD significantly (p 177 Lu). There was a low uptake in non-target organs and no induction of renal toxicity. 177 Lu-AuNP-RGD demonstrates properties suitable for use as an agent for molecular targeting radiotherapy. (Author)