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Sample records for plasmodium export element

  1. Role of plasmepsin V in export of diverse protein families from the Plasmodium falciparum exportome.

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    Boddey, Justin A; Carvalho, Teresa G; Hodder, Anthony N; Sargeant, Tobias J; Sleebs, Brad E; Marapana, Danushka; Lopaticki, Sash; Nebl, Thomas; Cowman, Alan F

    2013-05-01

    Plasmodium falciparum exports several hundred effector proteins that remodel the host erythrocyte and enable parasites to acquire nutrients, sequester in the circulation and evade immune responses. The majority of exported proteins contain the Plasmodium export element (PEXEL; RxLxE/Q/D) in their N-terminus, which is proteolytically cleaved in the parasite endoplasmic reticulum by Plasmepsin V, and is necessary for export. Several exported proteins lack a PEXEL or contain noncanonical motifs. Here, we assessed whether Plasmepsin V could process the N-termini of diverse protein families in P. falciparum. We show that Plasmepsin V cleaves N-terminal sequences from RIFIN, STEVOR and RESA multigene families, the latter of which contain a relaxed PEXEL (RxLxxE). However, Plasmepsin V does not cleave the N-terminal sequence of the major exported virulence factor erythrocyte membrane protein 1 (PfEMP1) or the PEXEL-negative exported proteins SBP-1 or REX-2. We probed the substrate specificity of Plasmepsin V and determined that lysine at the PEXEL P3 position, which is present in PfEMP1 and other putatively exported proteins, blocks Plasmepsin V activity. Furthermore, isoleucine at position P1 also blocked Plasmepsin V activity. The specificity of Plasmepsin V is therefore exquisitely confined and we have used this novel information to redefine the predicted P. falciparum PEXEL exportome.

  2. Protein export elements from Lactococcus lactis

    NARCIS (Netherlands)

    Perez-Martinez, Gaspar; Kok, Jan; Venema, Gerhardus; Dijl, Jan Maarten van; Smith, Hilda; Bron, Sierd

    1992-01-01

    Broad-host-range plasmids carrying α-amylase or β-lactamase reporter genes lacking a signal sequence were used to select export elements from Lactococcus lactis chromosomal DNA that could function as signal sequences. Fragments containing such elements were identified by their ability to direct the

  3. Protein export elements from Lactococcus lactis

    NARCIS (Netherlands)

    Perez-Martinez, Gaspar; Kok, Jan; Venema, Gerhardus; Dijl, Jan Maarten van; Smith, Hilda; Bron, Sierd

    Broad-host-range plasmids carrying α-amylase or β-lactamase reporter genes lacking a signal sequence were used to select export elements from Lactococcus lactis chromosomal DNA that could function as signal sequences. Fragments containing such elements were identified by their ability to direct the

  4. Proteomic and genetic analyses demonstrate that Plasmodium berghei blood stages export a large and diverse repertoire of proteins.

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    Pasini, Erica M; Braks, Joanna A; Fonager, Jannik; Klop, Onny; Aime, Elena; Spaccapelo, Roberta; Otto, Thomas D; Berriman, Matt; Hiss, Jan A; Thomas, Alan W; Mann, Matthias; Janse, Chris J; Kocken, Clemens H M; Franke-Fayard, Blandine

    2013-02-01

    Malaria parasites actively remodel the infected red blood cell (irbc) by exporting proteins into the host cell cytoplasm. The human parasite Plasmodium falciparum exports particularly large numbers of proteins, including proteins that establish a vesicular network allowing the trafficking of proteins onto the surface of irbcs that are responsible for tissue sequestration. Like P. falciparum, the rodent parasite P. berghei ANKA sequesters via irbc interactions with the host receptor CD36. We have applied proteomic, genomic, and reverse-genetic approaches to identify P. berghei proteins potentially involved in the transport of proteins to the irbc surface. A comparative proteomics analysis of P. berghei non-sequestering and sequestering parasites was used to determine changes in the irbc membrane associated with sequestration. Subsequent tagging experiments identified 13 proteins (Plasmodium export element (PEXEL)-positive as well as PEXEL-negative) that are exported into the irbc cytoplasm and have distinct localization patterns: a dispersed and/or patchy distribution, a punctate vesicle-like pattern in the cytoplasm, or a distinct location at the irbc membrane. Members of the PEXEL-negative BIR and PEXEL-positive Pb-fam-3 show a dispersed localization in the irbc cytoplasm, but not at the irbc surface. Two of the identified exported proteins are transported to the irbc membrane and were named erythrocyte membrane associated proteins. EMAP1 is a member of the PEXEL-negative Pb-fam-1 family, and EMAP2 is a PEXEL-positive protein encoded by a single copy gene; neither protein plays a direct role in sequestration. Our observations clearly indicate that P. berghei traffics a diverse range of proteins to different cellular locations via mechanisms that are analogous to those employed by P. falciparum. This information can be exploited to generate transgenic humanized rodent P. berghei parasites expressing chimeric P. berghei/P. falciparum proteins on the surface of

  5. J-dot targeting of an exported HSP40 in Plasmodium falciparum-infected erythrocytes.

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    Petersen, Wiebke; Külzer, Simone; Engels, Sonja; Zhang, Qi; Ingmundson, Alyssa; Rug, Melanie; Maier, Alexander G; Przyborski, Jude M

    2016-07-01

    Plasmodium falciparum exports a large number of proteins to its host cell, the mature human erythrocyte, where they are involved in host cell modification. Amongst the proteins trafficked to the host cell, many are heat shock protein (HSP)40 homologues. We previously demonstrated that at least two exported PfHSP40s (referred to as PFE55 and PFA660) localise to mobile structures in the P. falciparum-infected erythrocyte (Kulzer et al., 2010), termed J-dots. The complete molecular content of these structures has not yet been completely resolved, however it is known that they also contain an exported HSP70, PfHSP70x, and are potentially involved in transport of the major cytoadherance ligand, PfEMP1, through the host cell. To understand more about the nature of the association of exported HSP40s with J-dots, here we have studied the signal requirements for recruitment of the proteins to these structures. By expressing various exported GFP chimeras, we can demonstrate that the predicted substrate binding domain is necessary and sufficient for J-dot targeting. This targeting only occurs in human erythrocytes infected with P. falciparum, as it is not conserved when expressing a P. falciparum HSP40 in Plasmodium berghei-infected murine red blood cells, suggesting that J-dots are P. falciparum-specific. This data reveals a new mechanism for targeting of exported proteins to intracellular structures in the P. falciparum-infected erythrocyte.

  6. Identification of a new export signal in Plasmodium yoelii: identification of a new exportome.

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    Siau, Anthony; Huang, Ximei; Yam, Xue Yan; Bob, Ndeye Sakha; Sun, Hequan; Rajapakse, Jagath C; Renia, Laurent; Preiser, Peter R

    2014-05-01

    Development of the erythrocytic malaria parasite requires targeting of parasite proteins into multiple compartments located within and beyond the parasite confine. Beyond the PEXEL/VTS pathway and its characterized players, increasing amount of evidence has highlighted the existence of proteins exported using alternative export-signal(s)/pathway(s); hence, the exportomes currently predicted are incomplete. The nature of these exported proteins which could have a prominent role in most of the Plasmodium species remains elusive. Using P.  yoelii variant proteins, we identified a signal associated to lipophilic region that mediates export of P.  yoelii proteins. This non-PEXEL signal termed PLASMED is defined by semi-conserved residues and possibly a secondary structure. In vivo characterization of exported-proteins indicated that PLASMED is a bona fide export-signal that allowed us to identify an unseen P.  yoelii exportome. The repertoire of the newly predicted exported proteins opens up perspectives for unravelling the remodelling of the host-cell by the parasite, against which new therapies could be elaborated.

  7. A new Apicomplexa-specific protein kinase family : multiple members in Plasmodium falciparum, all with an export signature

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    Mercereau-Puijalon Odile

    2005-03-01

    Full Text Available Abstract Background Malaria caused by protozoan parasites of the genus Plasmodium spp. is a major health burden in tropical countries. The development of new control tools, including vaccines and drugs, is urgently needed. The availability of genome sequences from several malaria parasite species provides a basis on which to identify new potential intervention targets. Database mining for orthologs to the Plasmodium falciparum trophozoite protein R45, a vaccine candidate, led us identify a new gene family. Results Orthologs to the P. falciparum trophozoite protein R45 were detected exclusively in protozoan parasites of the phylum Apicomplexa, including several Plasmodium spp., Toxoplasma gondii and Cryptosporidium parvum. All family members are hybrid genes with a conserved C-terminal protein kinase domain of a novel type, recently called FIKK kinase, associated with a non conserved N-terminal region without any known functional signature. While a single copy gene was detected in most species, considerable gene expansion was observed in P. falciparum and its closest phylogenic relative P. reichenowi, with 20 and six copies, respectively, each with a distinct N-terminal domain. Based on full length protein sequence, pairs of orthologs were observed in closely related species, such as P. berghei and P.y. yoelii, P. vivax and P. knowlesi, or P. reichenowi and P. falciparum. All 20 P. falciparum paralogs possess a canonical Plasmodium export element downstream of a signal / anchor sequence required for exportation outside the parasitophorous vacuole. This is consistent with the reported association of the trophozoite protein R45, the only paralog characterised to date, with the infected red blood cell membrane. Interestingly, most genes are located in the subtelomeric region of chromosomes, in association with other multigene families contributing to the remodelling of the infected red blood cell membrane, in particular the ring erythrocyte surface

  8. Ticket to ride: export of proteins to the Plasmodium falciparum-infected erythrocyte.

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    Przyborski, Jude M; Nyboer, Britta; Lanzer, Michael

    2016-07-01

    The malaria parasite Plasmodium falciparum exports numerous proteins to its chosen host cell, the mature human erythrocyte. Many of these proteins are important for parasite survival. To reach the host cell, parasites must cross multiple membrane barriers and then furthermore be targeted to their correct sub-cellular localisation. This novel transport pathway has received much research attention in the past decades, especially as many of the mechanisms are expected to be parasite-specific and thus potential targets for drug development. In this article we summarize some of the most recent advances in this field, and highlight areas in which further research is needed.

  9. Hemoglobin S and C affect protein export in Plasmodium falciparum-infected erythrocytes

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    Nicole Kilian

    2015-02-01

    Full Text Available Malaria is a potentially deadly disease. However, not every infected person develops severe symptoms. Some people are protected by naturally occurring mechanisms that frequently involve inheritable modifications in their hemoglobin. The best studied protective hemoglobins are the sickle cell hemoglobin (HbS and hemoglobin C (HbC which both result from a single amino acid substitution in β-globin: glutamic acid at position 6 is replaced by valine or lysine, respectively. How these hemoglobinopathies protect from severe malaria is only partly understood. Models currently proposed in the literature include reduced disease-mediating cytoadherence of parasitized hemoglobinopathic erythrocytes, impaired intraerythrocytic development of the parasite, dampened inflammatory responses, or a combination thereof. Using a conditional protein export system and tightly synchronized Plasmodium falciparum cultures, we now show that export of parasite-encoded proteins across the parasitophorous vacuolar membrane is delayed, slower, and reduced in amount in hemoglobinopathic erythrocytes as compared to parasitized wild type red blood cells. Impaired protein export affects proteins targeted to the host cell cytoplasm, Maurer's clefts, and the host cell plasma membrane. Impaired protein export into the host cell compartment provides a mechanistic explanation for the reduced cytoadherence phenotype associated with parasitized hemoglobinopathic erythrocytes.

  10. Exported Epoxide Hydrolases Modulate Erythrocyte Vasoactive Lipids during Plasmodium falciparum Infection

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    Natalie J. Spillman

    2016-10-01

    Full Text Available Erythrocytes are reservoirs of important epoxide-containing lipid signaling molecules, including epoxyeicosatrienoic acids (EETs. EETs function as vasodilators and anti-inflammatory modulators in the bloodstream. Bioactive EETs are hydrolyzed to less active diols (dihydroxyeicosatrienoic acids by epoxide hydrolases (EHs. The malaria parasite Plasmodium falciparum infects host red blood cells (RBCs and exports hundreds of proteins into the RBC compartment. In this study, we show that two parasite epoxide hydrolases, P. falciparum epoxide hydrolases 1 (PfEH1 and 2 (PfEH2, both with noncanonical serine nucleophiles, are exported to the periphery of infected RBCs. PfEH1 and PfEH2 were successfully expressed in Escherichia coli, and they hydrolyzed physiologically relevant erythrocyte EETs. Mutations in active site residues of PfEH1 ablated the ability of the enzyme to hydrolyze an epoxide substrate. Overexpression of PfEH1 or PfEH2 in parasite-infected RBCs resulted in a significant alteration in the epoxide fatty acids stored in RBC phospholipids. We hypothesize that the parasite disruption of epoxide-containing signaling lipids leads to perturbed vascular function, creating favorable conditions for binding and sequestration of infected RBCs to the microvascular endothelium.

  11. Plasmodium falciparum Sec24 marks transitional ER that exports a model cargo via a diacidic motif.

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    Lee, Marcus C S; Moura, Pedro A; Miller, Elizabeth A; Fidock, David A

    2008-06-01

    Exit from the endoplasmic reticulum (ER) often occurs at distinct sites of vesicle formation known as transitional ER (tER) that are enriched for COPII vesicle coat proteins. We have characterized the organization of ER export in the malaria parasite, Plasmodium falciparum, by examining the localization of two components of the COPII machinery, PfSec12 and PfSec24a. PfSec12 was found throughout the ER, whereas the COPII cargo adaptor, PfSec24a, was concentrated at distinct foci that likely correspond to tER sites. These foci were closely apposed to cis-Golgi sites marked by PfGRASP-GFP, and upon treatment with brefeldin A they accumulated a model cargo protein via a process dependent on the presence of an intact diacidic export motif. Our data suggest that the cargo-binding function of PfSec24a is conserved and that accumulation of cargo in discrete tER sites depends upon positive sorting signals. Furthermore, the number and position of tER sites with respect to the cis-Golgi suggests a co-ordinated biogenesis of these domains.

  12. Variant Exported Blood-Stage Proteins Encoded by Plasmodium Multigene Families Are Expressed in Liver Stages Where They Are Exported into the Parasitophorous Vacuole.

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    Aurélie Fougère

    2016-11-01

    Full Text Available Many variant proteins encoded by Plasmodium-specific multigene families are exported into red blood cells (RBC. P. falciparum-specific variant proteins encoded by the var, stevor and rifin multigene families are exported onto the surface of infected red blood cells (iRBC and mediate interactions between iRBC and host cells resulting in tissue sequestration and rosetting. However, the precise function of most other Plasmodium multigene families encoding exported proteins is unknown. To understand the role of RBC-exported proteins of rodent malaria parasites (RMP we analysed the expression and cellular location by fluorescent-tagging of members of the pir, fam-a and fam-b multigene families. Furthermore, we performed phylogenetic analyses of the fam-a and fam-b multigene families, which indicate that both families have a history of functional differentiation unique to RMP. We demonstrate for all three families that expression of family members in iRBC is not mutually exclusive. Most tagged proteins were transported into the iRBC cytoplasm but not onto the iRBC plasma membrane, indicating that they are unlikely to play a direct role in iRBC-host cell interactions. Unexpectedly, most family members are also expressed during the liver stage, where they are transported into the parasitophorous vacuole. This suggests that these protein families promote parasite development in both the liver and blood, either by supporting parasite development within hepatocytes and erythrocytes and/or by manipulating the host immune response. Indeed, in the case of Fam-A, which have a steroidogenic acute regulatory-related lipid transfer (START domain, we found that several family members can transfer phosphatidylcholine in vitro. These observations indicate that these proteins may transport (host phosphatidylcholine for membrane synthesis. This is the first demonstration of a biological function of any exported variant protein family of rodent malaria parasites.

  13. Identification of new PNEPs indicates a substantial non-PEXEL exportome and underpins common features in Plasmodium falciparum protein export.

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    Heiber, Arlett; Kruse, Florian; Pick, Christian; Grüring, Christof; Flemming, Sven; Oberli, Alexander; Schoeler, Hanno; Retzlaff, Silke; Mesén-Ramírez, Paolo; Hiss, Jan A; Kadekoppala, Madhusudan; Hecht, Leonie; Holder, Anthony A; Gilberger, Tim-Wolf; Spielmann, Tobias

    2013-01-01

    Malaria blood stage parasites export a large number of proteins into their host erythrocyte to change it from a container of predominantly hemoglobin optimized for the transport of oxygen into a niche for parasite propagation. To understand this process, it is crucial to know which parasite proteins are exported into the host cell. This has been aided by the PEXEL/HT sequence, a five-residue motif found in many exported proteins, leading to the prediction of the exportome. However, several PEXEL/HT negative exported proteins (PNEPs) indicate that this exportome is incomplete and it remains unknown if and how many further PNEPs exist. Here we report the identification of new PNEPs in the most virulent malaria parasite Plasmodium falciparum. This includes proteins with a domain structure deviating from previously known PNEPs and indicates that PNEPs are not a rare exception. Unexpectedly, this included members of the MSP-7 related protein (MSRP) family, suggesting unanticipated functions of MSRPs. Analyzing regions mediating export of selected new PNEPs, we show that the first 20 amino acids of PNEPs without a classical N-terminal signal peptide are sufficient to promote export of a reporter, confirming the concept that this is a shared property of all PNEPs of this type. Moreover, we took advantage of newly found soluble PNEPs to show that this type of exported protein requires unfolding to move from the parasitophorous vacuole (PV) into the host cell. This indicates that soluble PNEPs, like PEXEL/HT proteins, are exported by translocation across the PV membrane (PVM), highlighting protein translocation in the parasite periphery as a general means in protein export of malaria parasites.

  14. The Exported Chaperone PfHsp70x Is Dispensable for the Plasmodium falciparum Intraerythrocytic Life Cycle.

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    Cobb, David W; Florentin, Anat; Fierro, Manuel A; Krakowiak, Michelle; Moore, Julie M; Muralidharan, Vasant

    2017-01-01

    Export of parasite proteins into the host erythrocyte is essential for survival of Plasmodium falciparum during its asexual life cycle. While several studies described key factors within the parasite that are involved in protein export, the mechanisms employed to traffic exported proteins within the host cell are currently unknown. Members of the Hsp70 family of chaperones, together with their Hsp40 cochaperones, facilitate protein trafficking in other organisms, and are thus likely used by P. falciparum in the trafficking of its exported proteins. A large group of Hsp40 proteins is encoded by the parasite and exported to the host cell, but only one Hsp70, P. falciparum Hsp70x (PfHsp70x), is exported with them. PfHsp70x is absent in most Plasmodium species and is found only in P. falciparum and closely related species that infect apes. Herein, we have utilized clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 genome editing in P. falciparum to investigate the essentiality of PfHsp70x. We show that parasitic growth was unaffected by knockdown of PfHsp70x using both the dihydrofolate reductase (DHFR)-based destabilization domain and the glmS ribozyme system. Similarly, a complete gene knockout of PfHsp70x did not affect the ability of P. falciparum to proceed through its intraerythrocytic life cycle. The effect of PfHsp70x knockdown/knockout on the export of proteins to the host red blood cell (RBC), including the critical virulence factor P. falciparum erythrocyte membrane protein 1 (PfEMP1), was tested, and we found that this process was unaffected. These data show that although PfHsp70x is the sole exported Hsp70, it is not essential for the asexual development of P. falciparum. IMPORTANCE Half of the world's population lives at risk for malaria. The intraerythrocytic life cycle of Plasmodium spp. is responsible for clinical manifestations of malaria; therefore, knowledge of the parasite's ability to survive within the erythrocyte is

  15. Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites

    DEFF Research Database (Denmark)

    Sleebs, Brad E; Lopaticki, Sash; Marapana, Danushka S

    2014-01-01

    The malaria parasite Plasmodium falciparum exports several hundred proteins into the infected erythrocyte that are involved in cellular remodeling and severe virulence. The export mechanism involves the Plasmodium export element (PEXEL), which is a cleavage site for the parasite protease, Plasmep...

  16. A repeat sequence domain of the ring-exported protein-1 of Plasmodium falciparum controls export machinery architecture and virulence protein trafficking.

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    McHugh, Emma; Batinovic, Steven; Hanssen, Eric; McMillan, Paul J; Kenny, Shannon; Griffin, Michael D W; Crawford, Simon; Trenholme, Katharine R; Gardiner, Donald L; Dixon, Matthew W A; Tilley, Leann

    2015-12-01

    The malaria parasite Plasmodium falciparum dramatically remodels its host red blood cell to enhance its own survival, using a secretory membrane system that it establishes outside its own cell. Cisternal organelles, called Maurer's clefts, act as a staging point for the forward trafficking of virulence proteins to the red blood cell (RBC) membrane. The Ring-EXported Protein-1 (REX1) is a Maurer's cleft resident protein. We show that inducible knockdown of REX1 causes stacking of Maurer's cleft cisternae without disrupting the organization of the knob-associated histidine-rich protein at the RBC membrane. Genetic dissection of the REX1 sequence shows that loss of a repeat sequence domain results in the formation of giant Maurer's cleft stacks. The stacked Maurer's clefts are decorated with tether-like structures and retain the ability to dock onto the RBC membrane skeleton. The REX1 mutant parasites show deficient export of the major virulence protein, PfEMP1, to the red blood cell surface and markedly reduced binding to the endothelial cell receptor, CD36. REX1 is predicted to form a largely α-helical structure, with a repetitive charge pattern in the repeat sequence domain, providing potential insights into the role of REX1 in Maurer's cleft sculpting.

  17. Moving in and renovating: exporting proteins from Plasmodium into host erythrocytes.

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    Goldberg, Daniel E; Cowman, Alan F

    2010-09-01

    Malaria parasites live within erythrocytes in the host bloodstream and induce crucial changes to these cells. By so doing, they can obtain the nutrients that they require for growth and can effect the evasion and perturbation of host defences. In order to accomplish this extensive host cell remodelling, the intracellular parasite exports hundreds of proteins to commander the erythrocyte for its own purposes. An export motif, a processing enzyme that specifies protein targeting and a translocon that mediates the export of proteins from the parasite into the host erythrocyte have been identified. However, important questions remain regarding the secretory pathway and the function of the translocon. In addition, this export pathway provides potentially useful targets for the development of inhibitors to interfere with functions that are vital for the virulence and survival programmes of the parasite.

  18. Diversion at the ER: How Plasmodium falciparum exports proteins into host erythrocytes.

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    Römisch, Karin

    2012-01-01

    Malaria is caused by parasites which live in host erythrocytes and remodel these cells to provide optimally for the parasites' needs by exporting effector proteins into the host cells. Eight years ago the discovery of a host cell targeting sequence present in both soluble and transmembrane  P. falciparum exported proteins generated a starting point for investigating the mechanism of parasite protein transport into infected erythrocytes. Since then many confusing facts about this targeting signal have emerged. In this paper, I try to make sense of them.

  19. Proteomic analysis reveals novel proteins associated with the Plasmodium protein exporter PTEX and a loss of complex stability upon truncation of the core PTEX component, PTEX150.

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    Elsworth, Brendan; Sanders, Paul R; Nebl, Thomas; Batinovic, Steven; Kalanon, Ming; Nie, Catherine Q; Charnaud, Sarah C; Bullen, Hayley E; de Koning Ward, Tania F; Tilley, Leann; Crabb, Brendan S; Gilson, Paul R

    2016-11-01

    The Plasmodium translocon for exported proteins (PTEX) has been established as the machinery responsible for the translocation of all classes of exported proteins beyond the parasitophorous vacuolar membrane of the intraerythrocytic malaria parasite. Protein export, particularly in the asexual blood stage, is crucial for parasite survival as exported proteins are involved in remodelling the host cell, an essential process for nutrient uptake, waste removal and immune evasion. Here, we have truncated the conserved C-terminus of one of the essential PTEX components, PTEX150, in Plasmodium falciparum in an attempt to create mutants of reduced functionality. Parasites tolerated C-terminal truncations of up to 125 amino acids with no reduction in growth, protein export or the establishment of new permeability pathways. Quantitative proteomic approaches however revealed a decrease in other PTEX subunits associating with PTEX150 in truncation mutants, suggesting a role for the C-terminus of PTEX150 in regulating PTEX stability. Our analyses also reveal three previously unreported PTEX-associated proteins, namely PV1, Pf113 and Hsp70-x (respective PlasmoDB numbers; PF3D7_1129100, PF3D7_1420700 and PF3D7_0831700) and demonstrate that core PTEX proteins exist in various distinct multimeric forms outside the major complex.

  20. A political economy of China's export restrictions on rare earth elements

    Energy Technology Data Exchange (ETDEWEB)

    Pothen, Frank [Zentrum fuer Europaeische Wirtschaftsforschung GmbH (ZEW), Mannheim (Germany); Fink, Kilian [Frankfurt Univ. (Germany)

    2015-04-20

    We investigate why governments restrict exports of exotic raw materials taking rare earth elements as a case study. Trade restrictions on exotic materials do not have immediate macroeconomic effects. Relocating rare earth intensive industries is found to be the main reason behind China's export barriers. They are part of a more extensive strategy aiming at creating comparative advantages in these sectors and at overcoming path dependencies. Moreover, export barriers serve as a second-best instrument to reduce pollution and to slow down the depletion of exhaustible resources. Growing domestic rare earth consumption renders those increasingly ineffective. Rising reliance on mine-site regulation indicates that this fact is taken into account. Rare earth extraction is dominated by a few large companies; the demand side is dispersed. That speaks against successful lobbying for export restrictions. It appears as if the export barriers are set up to compensate mining firms.

  1. Plasmodium species: master renovators of their host cells.

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    de Koning-Ward, Tania F; Dixon, Matthew W A; Tilley, Leann; Gilson, Paul R

    2016-08-01

    Plasmodium parasites, the causative agents of malaria, have developed elaborate strategies that they use to survive and thrive within different intracellular environments. During the blood stage of infection, the parasite is a master renovator of its erythrocyte host cell, and the changes in cell morphology and function that are induced by the parasite promote survival and contribute to the pathogenesis of severe malaria. In this Review, we discuss how Plasmodium parasites use the protein trafficking motif Plasmodium export element (PEXEL), protease-mediated polypeptide processing, a novel translocon termed the Plasmodium translocon of exported proteins (PTEX) and exomembranous structures to export hundreds of proteins to discrete subcellular locations in the host erythrocytes, which enables the parasite to gain access to vital nutrients and to evade the immune defence mechanisms of the host.

  2. The Plasmodium falciparum exported protein PF3D7_0402000 binds to erythrocyte ankyrin and band 4.1

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    Shakya, Bikash; Penn, Wesley D.; Nakayasu, Ernesto S.; LaCount, Douglas J.

    2017-09-01

    Plasmodium falciparum extensively modifies the infected red blood cell (RBC), resulting in changes in deformability, shape and surface properties. These alterations suggest that the RBC cytoskeleton is a major target for modification during infection. However, the molecular mechanisms leading to these changes are largely unknown. To begin to address this question, we screened for exported P. falciparum proteins that bound to the erythrocyte cytoskeleton proteins ankyrin 1 (ANK1) and band 4.1 (4.1R), which form critical interactions with other cytoskeletal proteins that contribute to the deformability and stability of RBCs. Yeast two-hybrid screens with ANK1 and 4.1R identified eight interactions with P. falciparum exported proteins, including an interaction between 4.1R and PF3D7_0402000 (PFD0090c). This interaction was first identified in a large-scale screen (Vignali et al., Malaria J, 7:211, 2008), which also reported an interaction between PF3D7_0402000 and ANK1. We confirmed the interactions of PF3D7_0402000 with 4.1R and ANK1 in pair-wise yeast two-hybrid and co-precipitation assays. In both cases, an intact PHIST domain in PF3D7_0402000 was required for binding. Complex purification followed by mass spectrometry analysis provided additional support for the interaction of PF3D7_0402000 with ANK1 and 4.1R. RBC ghost cells loaded with maltose-binding protein (MBP)-PF3D7_0402000 passed through a metal microsphere column less efficiently than mock- or MBP-loaded controls, consistent with an effect of PF3D7_0402000 on RBC rigidity or membrane stability. This study confirmed the interaction of PF3D7_0402000 with 4.1R in multiple independent assays, provided the first evidence that PF3D7_0402000 also binds to ANK1, and suggested that PF3D7_0402000 affects deformability or membrane stability of uninfected RBC ghosts.

  3. Element export from a small catchment in the tropical montane forest of Ecuador responds to climate change

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    Leimer, Sophia; Willimann, Elias; Alaoui, Abdallah; Trachte, Katja; Wilcke, Wolfgang

    2015-04-01

    In a very remote tropical montane rain forest in the Ecuadorian Andes on the rim of the Amazon basin, increasing temperatures, longer dry spells, and an associated reduction in soil moisture were observed in the past 15 years. In the study ecosystem, element exports from a 9-ha large catchment with stream water are linked to the depth of water flow through soil because of vertical variations in soil chemical properties. The further increase in temperature and precipitation, as predicted by climate models, will have an impact on the water flow paths in soil and therefore alter element exports. Hence, we investigated how future element exports from this catchment in Ecuador will develop under the emission scenarios A1B and B1 for the decades 2050-2059 and 2090-2099 compared to current element exports. Discharge from the study catchment was measured in 1998-2013, partly in high resolution. Element concentrations in stream water (total organic carbon, NO3-N, NH4-N, dissolved organic nitrogen, PO4-P, total dissolved phosphorus, S, Cl, K, Ca, Mg, Na, Zn, Al, Mn) were measured in 1998-2012 in weekly resolution. Based on catchment properties, measured climate, and water flow data, discharge in 1998-2013 was simulated in daily resolution with the hydrological model WaSiM. From the hydrograph of surface flow, three flow classes (baseflow, intermediate, storm) were separated and linked with stream chemical properties. Element concentrations in stream water were grouped according to the flow classes and mean concentrations per flow class were calculated. Subsequently, the mean element concentration was multiplied with the mean of the annual discharge sums per flow class resulting in current element exports. For estimations of future element exports with stream water, discharge was simulated under the emission scenarios A1B and B1 for the decades 2050-2059 and 2090-2099 and separated into the three flow classes. Future element exports per scenario were calculated according to

  4. 10 CFR Appendix O to Part 110 - Illustrative List of Fuel Element Fabrication Plant Equipment and Components Under NRC's Export...

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Illustrative List of Fuel Element Fabrication Plant... Appendix O to Part 110—Illustrative List of Fuel Element Fabrication Plant Equipment and Components Under NRC's Export Licensing Authority Note: Nuclear fuel elements are manufactured from source or...

  5. Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites

    DEFF Research Database (Denmark)

    Sleebs, Brad E; Lopaticki, Sash; Marapana, Danushka S;

    2014-01-01

    The malaria parasite Plasmodium falciparum exports several hundred proteins into the infected erythrocyte that are involved in cellular remodeling and severe virulence. The export mechanism involves the Plasmodium export element (PEXEL), which is a cleavage site for the parasite protease......, Plasmepsin V (PMV). The PMV gene is refractory to deletion, suggesting it is essential, but definitive proof is lacking. Here, we generated a PEXEL-mimetic inhibitor that potently blocks the activity of PMV isolated from P. falciparum and Plasmodium vivax. Assessment of PMV activity in P. falciparum revealed...... surface, and cytoadherence. The inhibitor killed parasites at the trophozoite stage and knockdown of PMV enhanced sensitivity to the inhibitor, while overexpression of PMV increased resistance. This provides the first direct evidence that PMV activity is essential for protein export in Plasmodium spp...

  6. HIV-1 and M-PMV RNA Nuclear Export Elements Program Viral Genomes for Distinct Cytoplasmic Trafficking Behaviors.

    Science.gov (United States)

    Pocock, Ginger M; Becker, Jordan T; Swanson, Chad M; Ahlquist, Paul; Sherer, Nathan M

    2016-04-01

    Retroviruses encode cis-acting RNA nuclear export elements that override nuclear retention of intron-containing viral mRNAs including the full-length, unspliced genomic RNAs (gRNAs) packaged into assembling virions. The HIV-1 Rev-response element (RRE) recruits the cellular nuclear export receptor CRM1 (also known as exportin-1/XPO1) using the viral protein Rev, while simple retroviruses encode constitutive transport elements (CTEs) that directly recruit components of the NXF1(Tap)/NXT1(p15) mRNA nuclear export machinery. How gRNA nuclear export is linked to trafficking machineries in the cytoplasm upstream of virus particle assembly is unknown. Here we used long-term (>24 h), multicolor live cell imaging to directly visualize HIV-1 gRNA nuclear export, translation, cytoplasmic trafficking, and virus particle production in single cells. We show that the HIV-1 RRE regulates unique, en masse, Rev- and CRM1-dependent "burst-like" transitions of mRNAs from the nucleus to flood the cytoplasm in a non-localized fashion. By contrast, the CTE derived from Mason-Pfizer monkey virus (M-PMV) links gRNAs to microtubules in the cytoplasm, driving them to cluster markedly to the centrosome that forms the pericentriolar core of the microtubule-organizing center (MTOC). Adding each export element to selected heterologous mRNAs was sufficient to confer each distinct export behavior, as was directing Rev/CRM1 or NXF1/NXT1 transport modules to mRNAs using a site-specific RNA tethering strategy. Moreover, multiple CTEs per transcript enhanced MTOC targeting, suggesting that a cooperative mechanism links NXF1/NXT1 to microtubules. Combined, these results reveal striking, unexpected features of retroviral gRNA nucleocytoplasmic transport and demonstrate roles for mRNA export elements that extend beyond nuclear pores to impact gRNA distribution in the cytoplasm.

  7. Urbanization and agriculture increase exports and differentially alter elemental stoichiometry of dissolved organic matter (DOM) from tropical catchments

    DEFF Research Database (Denmark)

    Gücker, Björn; Silva, Ricky C. S.; Graeber, Daniel

    2016-01-01

    ) concentrations, but consistent effects on DOM elemental stoichiometry have not yet been reported. Here, we studied stream water DOC concentrations, catchment DOC exports, and DOM elemental stoichiometry in 20 tropical catchments at the Cerrado–Atlantic rainforest transition, dominated by natural vegetation......, pasture, intensive agriculture, and urban land cover. Streams draining pasture could be distinguished from those draining natural catchments by their lower DOC concentrations, with lower DOM C:N and C:P ratios. Catchments with intensive agriculture had higher DOC exports and lower DOM C:P ratios than...... natural catchments. Finally, with the highest DOC concentrations and exports, as well as the highest DOM C:P and N:P ratios, but the lowest C:N ratios among all land-use types, urbanized catchments had the strongest effects on catchment DOM. Thus, urbanization may have alleviated N limitation...

  8. An exported kinase (FIKK4.2) that mediates virulence-associated changes in Plasmodium falciparum-infected red blood cells.

    Science.gov (United States)

    Kats, Lev M; Fernandez, Kate M; Glenister, Fiona K; Herrmann, Susann; Buckingham, Donna W; Siddiqui, Ghizal; Sharma, Laveena; Bamert, Rebecca; Lucet, Isabelle; Guillotte, Micheline; Mercereau-Puijalon, Odile; Cooke, Brian M

    2014-04-01

    Alteration of the adhesive and mechanical properties of red blood cells caused by infection with the malaria parasite Plasmodium falciparum underpin both its survival and extreme pathogenicity. A unique family of parasite putative exported kinases, collectively called FIKK (Phenylalanine (F) - Isoleucine (I) - Lysine (K) - Lysine (K)), has recently been implicated in these pathophysiological processes, however, their precise function in P. falciparum-infected red blood cells or their likely role in malaria pathogenesis remain unknown. Here, for the first time, we demonstrate that one member of the FIKK family, FIKK4.2, can function as an active kinase and is localised in a novel and distinct compartment of the parasite-infected red blood cell which we have called K-dots. Notably, targeted disruption of the gene encoding FIKK4.2 (fikk4.2) dramatically alters the parasite's ability to modify and remodel the red blood cells in which it multiplies. Specifically, red blood cells infected with fikk4.2 knockout parasites were significantly less rigid and less adhesive when compared with red blood cells infected with normal parasites from which the transgenic clones had been derived, despite expressing similar levels of the major cytoadhesion ligand, PfEMP1, on the red blood cell surface. Notably, these changes were accompanied by dramatically altered knob-structures on infected red blood cells that play a key role in cytoadhesion which is responsible for much of the pathogenesis associated with falciparum malaria. Taken together, our data identifies FIKK4.2 as an important kinase in the pathogenesis of P. falciparum malaria and strengthens the attractiveness of FIKK kinases as targets for the development of novel next-generation anti-malaria drugs.

  9. Priority Processing of Effective Packing Elements on Increasing Greenhouse Products Exports in Viewpoint of Russian Reporters (Case Study of Greenhouse Cucumber

    Directory of Open Access Journals (Sweden)

    Issa Fahim

    2012-12-01

    Full Text Available This research analyzed Priority processing of effective packing elements on increasing greenhouse products exports in viewpoint of Russian reporters. Statistics society of the research includes 44 people. Provided questionnaire was distributed among them which 30 questionnaire were returned. This is a questionnaire research in which questionnaire comprises two sections. To process the priority of packing elements from greenhouse products average index was used. To answer the main question of research, “Weather packing elements of goods influences increasing greenhouse products exports to Russia in viewpoint of Russian reports?” We examined five equations which are explained in the form of five hypotheses. In this research we try to determine that in view point of Russia reporter which elements of packing greenhouse cucumber has a meaningful relation to increasing exports and in other words, between which element and increasing exports to Russia there is no special relation. After doing some studies, interviews and distributing questionnaires, results showed that elements of package color, package weight and facility of opening the package influence increasing exports and in other side, two elements of package quality and package compatibility with environment don’t influence increasing exports.

  10. Urbanization and agriculture increase exports and differentially alter elemental stoichiometry of dissolved organic matter (DOM) from tropical catchments.

    Science.gov (United States)

    Gücker, Björn; Silva, Ricky C S; Graeber, Daniel; Monteiro, José A F; Boëchat, Iola G

    2016-04-15

    Many tropical biomes are threatened by rapid land-use change, but its catchment-wide biogeochemical effects are poorly understood. The few previous studies on DOM in tropical catchments suggest that deforestation and subsequent land use increase stream water dissolved organic carbon (DOC) concentrations, but consistent effects on DOM elemental stoichiometry have not yet been reported. Here, we studied stream water DOC concentrations, catchment DOC exports, and DOM elemental stoichiometry in 20 tropical catchments at the Cerrado-Atlantic rainforest transition, dominated by natural vegetation, pasture, intensive agriculture, and urban land cover. Streams draining pasture could be distinguished from those draining natural catchments by their lower DOC concentrations, with lower DOM C:N and C:P ratios. Catchments with intensive agriculture had higher DOC exports and lower DOM C:P ratios than natural catchments. Finally, with the highest DOC concentrations and exports, as well as the highest DOM C:P and N:P ratios, but the lowest C:N ratios among all land-use types, urbanized catchments had the strongest effects on catchment DOM. Thus, urbanization may have alleviated N limitation of heterotrophic DOM decomposition, but increased P limitation. Land use-especially urbanization-also affected the seasonality of catchment biogeochemistry. While natural catchments exhibited high DOC exports and concentrations, with high DOM C:P ratios in the rainy season only, urbanized catchments had high values in these variables throughout the year. Our results suggest that urbanization and pastoral land use exerted the strongest impacts on DOM biogeochemistry in the investigated tropical catchments and should thus be important targets for management and mitigation efforts.

  11. One electronic document accepted by importer and exporter authorities: Blue Path as an element of integration and traceability

    Directory of Open Access Journals (Sweden)

    Scoton Maria L. R. P. D.

    2016-01-01

    Full Text Available The Blue Path (CA-e is an document created and transmitted electronically that contains all necessary data to allow the sanitary authority to analyze the requirement of exportation that will result on the sanitary clearance of the animal protein for exportation. Actually it is in use in Brazil. However, even though the data exists electronically, when it is send to the importer country some must be sent on paper, because the bilateral agreements do not allow the exchange of electronic documents. The present work proposals the extension of the CA-e, as an element of integration and traceability, that will allow the automation of the communication between private and public systems not only at Brazil, the country of the origin of the animal protein exported, but also between and at the country of destiny. Based on the number presented by the adoption of the CA-e at Brazil, it is fair to conclude that this communication machine/machine would bring great economy and optimization for the supply chain.

  12. Diversion at the ER: How Plasmodium falciparum exports proteins into host erythrocytes [v2; ref status: indexed, http://f1000r.es/VOUzka

    Directory of Open Access Journals (Sweden)

    Karin Römisch

    2012-12-01

    Full Text Available Malaria is caused by parasites which live in host erythrocytes and remodel these cells to provide optimally for the parasites’ needs by exporting effector proteins into the host cells. Eight years ago the discovery of a host cell targeting sequence present in both soluble and transmembrane P. falciparum exported proteins generated a starting point for investigating the mechanism of parasite protein transport into infected erythrocytes. Since then many confusing facts about this targeting signal have emerged. In this paper, I try to make sense of them.

  13. Trafficking of STEVOR to the Maurer's clefts in Plasmodium falciparum -infected erythrocytes

    National Research Council Canada - National Science Library

    Przyborski, Jude M; Miller, Susanne K; Rohrbach, Petra; Pfahler, Judith M; Crabb, Brendan S; Henrich, Philipp P; Lanzer, Michael

    2005-01-01

    The human malarial parasite Plasmodium falciparum exports proteins to destinations within its host erythrocyte, including cytosol, surface and membranous profiles of parasite origin termed Maurer's clefts...

  14. Targeted disruption of a ring-infected erythrocyte surface antigen (RESA)-like export protein gene in Plasmodium falciparum confers stable chondroitin 4-sulfate cytoadherence capacity

    DEFF Research Database (Denmark)

    Goel, Suchi; Muthusamy, Arivalagan; Miao, Jun

    2014-01-01

    . In this study, microarray transcriptome analysis showed that the absence of a gene cluster, comprising kahrp, pfemp3, and four other genes, results in the loss of parasitized erythrocytes adhering to chondroitin 4-sulfate (C4S). The role of one of these genes, PF3D7_0201600/PFB0080c, which encodes PHISTb......The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family proteins mediate the adherence of infected erythrocytes to microvascular endothelia of various organs, including the placenta, thereby contributing to cerebral, placental, and other severe malaria pathogenesis. Several...... that the loss of PFB0080c markedly compromises the var gene switching process, leading to a marked reduction in the switching rate and additional PfEMP1 expression by a minor population of parasites. PFB0080c interacts with VAR2CSA and modulates knob-associated Hsp40 expression. Thus, PFB0080c may regulate VAR2...

  15. Plasmodium Immunomics

    Science.gov (United States)

    Doolan, Denise L.

    2010-01-01

    The Plasmodium parasite, the causative agent of malaria, is an excellent model for immunomic-based approaches to vaccine development. The Plasmodium parasite has a complex life cycle with multiple stages and stage-specific expression of ~ 5,300 putative proteins. No malaria vaccine has yet been licensed. Many believe that an effective vaccine will need to target several antigens and multiple stages, and will require the generation of both antibody and cellular immune responses. Vaccine efforts to date have been stage-specific and based on only a very limited number of proteins representing Plasmodium parasite life cycle with immune responses implicated in parasite elimination and control. Immunomic approaches which enable the selection of the best possible targets by prioritizing antigens according to clinically relevant criteria may overcome the problem of poorly immunogenic, poorly protective vaccines that has plagued malaria vaccine developers for the past 25 years. Herein, current progress and perspectives regarding Plasmodium immunomics are reviewed. PMID:20816843

  16. Alterations in early cytokine-mediated immune responses to Plasmodium falciparum infection in Tanzanian children with mineral element deficiencies: a cross-sectional survey

    Directory of Open Access Journals (Sweden)

    Jeurink Prescilla V

    2010-05-01

    Full Text Available Abstract Background Deficiencies in vitamins and mineral elements are important causes of morbidity in developing countries, possibly because they lead to defective immune responses to infection. The aim of the study was to assess the effects of mineral element deficiencies on early innate cytokine responses to Plasmodium falciparum malaria. Methods Peripheral blood mononuclear cells from 304 Tanzanian children aged 6-72 months were stimulated with P. falciparum-parasitized erythrocytes obtained from in vitro cultures. Results The results showed a significant increase by 74% in geometric mean of TNF production in malaria-infected individuals with zinc deficiency (11% to 240%; 95% CI. Iron deficiency anaemia was associated with increased TNF production in infected individuals and overall with increased IL-10 production, while magnesium deficiency induced increased production of IL-10 by 46% (13% to 144% in uninfected donors. All donors showed a response towards IL-1β production, drawing special attention for its possible protective role in early innate immune responses to malaria. Conclusions In view of these results, the findings show plasticity in cytokine profiles of mononuclear cells reacting to malaria infection under conditions of different micronutrient deficiencies. These findings lay the foundations for future inclusion of a combination of precisely selected set of micronutrients rather than single nutrients as part of malaria vaccine intervention programmes in endemic countries.

  17. Regulatory elements within the prodomain of Falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum.

    Directory of Open Access Journals (Sweden)

    Kailash C Pandey

    Full Text Available Falcipain-2, a papain family cysteine protease of the malaria parasite Plasmodium falciparum, plays a key role in parasite hydrolysis of hemoglobin and is a potential chemotherapeutic target. As with many proteases, falcipain-2 is synthesized as a zymogen, and the prodomain inhibits activity of the mature enzyme. To investigate the mechanism of regulation of falcipain-2 by its prodomain, we expressed constructs encoding different portions of the prodomain and tested their ability to inhibit recombinant mature falcipain-2. We identified a C-terminal segment (Leu(155-Asp(243 of the prodomain, including two motifs (ERFNIN and GNFD that are conserved in cathepsin L sub-family papain family proteases, as the mediator of prodomain inhibitory activity. Circular dichroism analysis showed that the prodomain including the C-terminal segment, but not constructs lacking this segment, was rich in secondary structure, suggesting that the segment plays a crucial role in protein folding. The falcipain-2 prodomain also efficiently inhibited other papain family proteases, including cathepsin K, cathepsin L, cathepsin B, and cruzain, but it did not inhibit cathepsin C or tested proteases of other classes. A structural model of pro-falcipain-2 was constructed by homology modeling based on crystallographic structures of mature falcipain-2, procathepsin K, procathepsin L, and procaricain, offering insights into the nature of the interaction between the prodomain and mature domain of falcipain-2 as well as into the broad specificity of inhibitory activity of the falcipain-2 prodomain.

  18. Mercury and trace element distribution in density separates of a South African Highveld (#4) coal: Implications for mercury reduction and preparation of export coal

    Science.gov (United States)

    Kolker, Allan; Senior, Connie L.; van Alphen, Chris; Koenig, Alan E.; Geboy, Nicholas J.

    2017-01-01

    Eight density separates of Permian Highveld (#4) coal were investigated for partitioning of Hg and trace elements. The separates include float fractions obtained in heavy media having densities of 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, and 2.0 g/cm3, and the sink fraction for 2.0 g/cm3. Bulk analysis of the separates shows strong (R2 ≥ 0.80) positive correlations between pyritic sulfur and mercury, and between ash yield and both pyritic sulfur and mercury. Laser ablation (LA) ICP-MS analysis of individual pyrite grains in the separates confirms association of Hg and As with pyrite as indicated by bulk analysis. Other elements detected in pyrite by LA-ICP-MS include Mn, Co, Ni, Tl, and Pb. Results for the separates allow prediction of Hg, trace elements, and ash yields expected in specific South African coal products. These range from 0.06 ppm Hg and an ash yield of 11.5% ash for the export fraction to 0.47 ppm Hg and an ash yield of 60.9% for the discard (stone) fraction (dry basis). Results show pronounced differences expected between coal used for domestic power generation and coal which is exported.

  19. Export strategy

    DEFF Research Database (Denmark)

    Knudsen, Thorbjørn; Koed Madsen, Tage

    2002-01-01

    It is argued here that traditional export strategy research (encompassing the study of internationalization processes and export performance) is characterized by weak theoretical foundations and could benefit from a reorientation towards a dynamic capabilities perspective (DCP). We seek to draw...... on insights from DCP in order to devise a theoretical basis that could enrich export strategy research. Although our development of DCP insights builds on previous work, it also adds a crucial distinction between knowledge stocks and informational architecture. Changes in architecture are of greater...... importance. Following this elaboration of the dynamic capabilities perspective, we outline some implications and guidelines for future export strategy research....

  20. Normalization as an element of competitiveness and export potential; La normalizacion como elemento de competitividad y de potencial exportador

    Energy Technology Data Exchange (ETDEWEB)

    Brito Marquina, A.

    2015-07-01

    The Spanish technical standards catalogue contains over 31.000 standards, half a million pages, most of them in Spanish. Virtually every sector finds in technical standards the good practice accepted by the market, for many elements relevant for competitiveness. They are internationally accepted documents that facilitate access to markets, provide quality and safety assurance, and meet legal obligations in a global environment. This is one of the main contributions of the Spanish Association for Standardization and Certification, an organization founded in 1986 when the standardization activity moved from the public sector to a non-profit entity, in which the private sector could drive and support this activity. (Author)

  1. A Plasmodium falciparum S33 proline aminopeptidase is associated with changes in erythrocyte deformability.

    Science.gov (United States)

    da Silva, Fabio L; Dixon, Matthew W A; Stack, Colin M; Teuscher, Franka; Taran, Elena; Jones, Malcolm K; Lovas, Erica; Tilley, Leann; Brown, Christopher L; Trenholme, Katharine R; Dalton, John P; Gardiner, Donald L; Skinner-Adams, Tina S

    2016-10-01

    Infection with the apicomplexan parasite Plasmodium falciparum is a major cause of morbidity and mortality worldwide. One of the striking features of this parasite is its ability to remodel and decrease the deformability of host red blood cells, a process that contributes to disease. To further understand the virulence of Pf we investigated the biochemistry and function of a putative Pf S33 proline aminopeptidase (PfPAP). Unlike other P. falciparum aminopeptidases, PfPAP contains a predicted protein export element that is non-syntenic with other human infecting Plasmodium species. Characterization of PfPAP demonstrated that it is exported into the host red blood cell and that it is a prolyl aminopeptidase with a preference for N-terminal proline substrates. In addition genetic deletion of this exopeptidase was shown to lead to an increase in the deformability of parasite-infected red cells and in reduced adherence to the endothelial cell receptor CD36 under flow conditions. Our studies suggest that PfPAP plays a role in the rigidification and adhesion of infected red blood cells to endothelial surface receptors, a role that may make this protein a novel target for anti-disease interventions strategies.

  2. Molecular characterization and phylogenetic analysis of Plasmodium vivax, Plasmodium falciparum, Plasmodium ovale, Plasmodium malariae and Plasmodium cynomolgi

    National Research Council Canada - National Science Library

    Chatterjee, Soumendranath; Mukhopadhyay, Priyanka; Bandyopadhyay, Raktima; Dhal, Paltu; Biswal, Debraj; Bandyopadhyay, Prabir Kumar

    18S ribosomal RNA gene sequences of different species of Plasmodium were aligned and analyzed to determine the molecular diversity among different species of Plasmodium. AT content of P. cynomolgi, P. ovale, P. falciparum, P. vivax and P...

  3. Export spillovers

    DEFF Research Database (Denmark)

    Choquette, Eliane; Meinen, Philipp

    2015-01-01

    -industry linkages. We do so by exploiting a unique data set covering the universe of manufacturing firms in Denmark for the period 1995–2006 which combines transaction-level export data, firm accounting data, employer–employee linked data and information from yearly input–output tables. We corroborate...

  4. Fixed Export Costs and Export Behavior

    OpenAIRE

    Castro, Luis; Li, Ben; Keith E. Maskus; Xie, Yiqing

    2014-01-01

    This paper provides a direct test of how fixed export costs and productivity jointly determine firm-level export behavior. Using Chilean data, we construct indices of fixed export costs for each industry-region-year triplet and match them to domestic firms. Our empirical results show that firms facing higher fixed export costs are less likely to export, while those with higher productivity export more. These outcomes are the foundation of the widely-used sorting mechanism in the trade models ...

  5. Promoter regions of Plasmodium vivax are poorly or not recognized by Plasmodium falciparum

    Directory of Open Access Journals (Sweden)

    del Portillo Hernando A

    2007-02-01

    Full Text Available Abstract Background Heterologous promoter analysis in Plasmodium has revealed the existence of conserved cis regulatory elements as promoters from different species can drive expression of reporter genes in heterologous transfection assays. Here, the functional characterization of different Plasmodium vivax promoters in Plasmodium falciparum using luciferase as the reporter gene is presented. Methods Luciferase reporter plasmids harboring the upstream regions of the msp1, dhfr, and vir3 genes as well as the full-length intergenic regions of the vir23/24 and ef-1α genes of P. vivax were constructed and transiently transfected in P. falciparum. Results Only the constructs with the full-length intergenic regions of the vir23/24 and ef-1α genes were recognized by the P. falciparum transcription machinery albeit to values approximately two orders of magnitude lower than those reported by luc plasmids harbouring promoter regions from P. falciparum and Plasmodium berghei. A bioinformatics approach allowed the identification of a motif (GCATAT in the ef-1α intergenic region that is conserved in five Plasmodium species but is degenerate (GCANAN in P. vivax. Mutations of this motif in the P. berghei ef-1α promoter region decreased reporter expression indicating it is active in gene expression in Plasmodium. Conclusion Together, this data indicates that promoter regions of P. vivax are poorly or not recognized by the P. falciparum transcription machinery suggesting the existence of P. vivax-specific transcription regulatory elements.

  6. Trends of wood window and door consumption in Spain, France and Germany as elements of strategy for their export from Serbia

    Directory of Open Access Journals (Sweden)

    Ranković Nenad

    2007-01-01

    Full Text Available The paper gives results of the analysis of econometric models and trends of wood window and door consumption in Spain, France and Germany in the period 2008-2012. The results of the analysis are important for the process of creating export strategy for the chosen wood products from Serbia on the markets of the chosen countries. For each of the abovementioned markets, main recommendations in view of the possibilities for wood windows and doors export from Serbia are given, as well as the recommendations for the appearance of domestic producers on each of the chosen markets.

  7. Trends of wood window and door consumption in Spain, France and Germany as elements of strategy for their export from Serbia

    OpenAIRE

    Ranković Nenad; Glavonjić Branko; Oblak Leon; Petrović Slavica

    2007-01-01

    The paper gives results of the analysis of econometric models and trends of wood window and door consumption in Spain, France and Germany in the period 2008-2012. The results of the analysis are important for the process of creating export strategy for the chosen wood products from Serbia on the markets of the chosen countries. For each of the abovementioned markets, main recommendations in view of the possibilities for wood windows and doors export from Serbia are given, as well as the recom...

  8. PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes.

    Science.gov (United States)

    Beck, Josh R; Muralidharan, Vasant; Oksman, Anna; Goldberg, Daniel E

    2014-07-31

    To mediate its survival and virulence, the malaria parasite Plasmodium falciparum exports hundreds of proteins into the host erythrocyte. To enter the host cell, exported proteins must cross the parasitophorous vacuolar membrane (PVM) within which the parasite resides, but the mechanism remains unclear. A putative Plasmodium translocon of exported proteins (PTEX) has been suggested to be involved for at least one class of exported proteins; however, direct functional evidence for this has been elusive. Here we show that export across the PVM requires heat shock protein 101 (HSP101), a ClpB-like AAA+ ATPase component of PTEX. Using a chaperone auto-inhibition strategy, we achieved rapid, reversible ablation of HSP101 function, resulting in a nearly complete block in export with substrates accumulating in the vacuole in both asexual and sexual parasites. Surprisingly, this block extended to all classes of exported proteins, revealing HSP101-dependent translocation across the PVM as a convergent step in the multi-pathway export process. Under export-blocked conditions, association between HSP101 and other components of the PTEX complex was lost, indicating that the integrity of the complex is required for efficient protein export. Our results demonstrate an essential and universal role for HSP101 in protein export and provide strong evidence for PTEX function in protein translocation into the host cell.

  9. Expanding Exports: Can Tennessee Double Its Exports?

    OpenAIRE

    Steven G. Livingston

    2010-01-01

    In this year's State of the Union Address, President Obama announced a National Export Initiative to double American exports over the next five years. He claimed that this could add two million jobs to the American economy. Could Tennessee actually double its exports over this period? And what would be the impact if it did?

  10. Beech wood export and import trends in Serbia

    Directory of Open Access Journals (Sweden)

    Ranković Nenad

    2004-01-01

    Full Text Available By the establishment and analysis of the model of beech wood export and export trends in Serbia (by quantity and value, for the period 1988-2002 the regularities of the changes of their magnitude in time were defined. On this basis, the relations of import and export trends were analyzed. Based on the study elements, the potentials of beech sawlog and beech sawnwood export, as well as the potential economic effects, were pointed out.

  11. Demand Uncertainty: Exporting Delays and Exporting Failures

    DEFF Research Database (Denmark)

    Nguyen, Daniel Xuyen

    2012-01-01

    This paper presents a model of trade that explains why firms wait to export and why many exporters fail. Firms face uncertain demands that are only realized after the firm enters the destination. The model retools the timing of the resolution of uncertainty found in models with heterogeneity...... to forecast unknown demands in untested destinations. The option to forecast demands causes firms to delay exporting in order to gather more information about foreign demand. Third, since uncertainty is resolved after entry, many firms enter a destination and then exit after learning that they cannot profit....... This prediction reconciles the high rate of exit seen in the first years of exporting. Finally, when faced with multiple destinations to which they can export, many firms will choose to sequentially export in order to slowly learn more about its chances for success in untested markets....

  12. 出口食品生产企业备案监管要素量化评估模型的构建%Establishment of registration supervision element mathematics evaluation model for export food manufactures

    Institute of Scientific and Technical Information of China (English)

    刘建芳; 李红权; 刘芳; 蔡晶晶

    2016-01-01

    目的:构建出口食品生产企业监管要素量化评估模型。方法运用模糊数学综合评价概念,在对出口食品生产企业备案监管要素研究分析的基础上,选取具有代表性的指标体系,并依据模糊数学综合评价法和层次分析法理论,建立层次结构模型、构造判断矩阵、权重的计算和一致性检验,将整个监管指标过程数学化。结果该模型的9个一级监管要素覆盖了出口食品生产企业的全部监管内容,二级、三级监管要素将企业各项监管内容进一步细化,具有科学性和实用性。结论构建的出口食品生产企业监管要素量化评估模型,为检验检疫监管部门提供详细的评估体系。对检验检疫局科学有效地评估企业,指导企业的能力和管理提升很有实用价值,符合现代管理理念,使评价从制度上和实施组织架构上更公正、客观、高效。%ABSTRACT:Objective To establish a quantitative evaluation model for the supervision elements of export food manufactures. Methods The method of fuzzy mathematics comprehensive evaluation concept was used, and the hierarchy structure model, judgment matrix, calculating weight and check consistency were established based on the analysis of the record of supervision elements for the export of food manufactures, selecting index system of representative, and based on the analysis of the comprehensive evaluation method of fuzzy mathematics and analytic hierarchy process (AHP) theory, and then the whole process of the supervision was mathematical process. Results Nine first-level supervision elements of the model covered all supervision content of the export food manufactures, and the second- and third-level of supervision elements were further refine the regulatory content of the enterprise, which were scientific and practical. Conclusion The quantitative evaluation model for the supervision elements of the export food manufactures is

  13. Learning by Exporting

    DEFF Research Database (Denmark)

    Cruz, Antonio; Newman, Carol; Rand, John

    2017-01-01

    In this article, we analyse the learning-by-exporting (LBE) hypothesis in the Mozambican context. Due to the presence of the ‘Born-Global’ phenomenon among exporters, we address the endogeneity introduced by self-selection, combining a generalised Blinder–Oaxaca approach with results from...... traditional matching techniques. Our results show that very few manufacturing firms export, and that export participation is highly persistent. There is also evidence supporting the LBE hypothesis and the results suggest a significant export premium of between 17 and 21%, controlling for differences...... in observable characteristics between exporters and non-exporters. Finally, qualitative information on non-exporters seeking new markets suggests that ‘lack of knowledge of potential markets’ is the most severe constraint to international market entry. We conclude that the Mozambican Export Promotion Institute...

  14. Plasmodium and mononuclear phagocytes.

    Science.gov (United States)

    Mac-Daniel, Laura; Ménard, Robert

    2015-01-01

    Plasmodium, the causative agent of malaria, initially multiplies inside liver cells and then in successive cycles inside erythrocytes, causing the symptoms of the disease. In this review, we discuss interactions between the extracellular and intracellular forms of the Plasmodium parasite and innate immune cells in the mammalian host, with a special emphasis on mononuclear phagocytes. We overview here what is known about the innate immune cells that interact with parasites, mechanisms used by the parasite to evade them, and the protective or detrimental contribution of these interactions on parasite progression through its life cycle and pathology in the host.

  15. Logistics and Exports

    OpenAIRE

    2008-01-01

    Drawing on a new and comprehensive measure of logistics quality, our gravity model suggests logistics in the exporting and partner-country can have an important impact on bilateral exports. A one standard deviation improvement in the exporter’s logistics quality, which for example would improve Gabon to the level of Guinea, would raise exports by almost 60%. Landlocked countries’ exports depend on their neighbours’ logistics, but their own logistics quality is not as important as for other co...

  16. Plasmodium falciparum Plasmepsin V (PfPMV): Insights into recombinant expression, substrate specificity and active site structure.

    Science.gov (United States)

    Boonyalai, Nonlawat; Sittikul, Pichamon; Yuvaniyama, Jirundon

    2015-05-01

    Plasmepsin V from Plasmodium falciparum (PfPMV) is responsible for the cleavage of the Plasmodium export element (PEXEL) motif at the N-terminus of several hundreds of the exported proteins. PfPMV is necessary for parasite viability and has become a novel promising target for antimalarial therapy. The first recombinant expression of soluble, active PfPMV as thioredoxin fusion proteins is reported herein. Two truncated forms of PfPMV were fused to thioredoxin (Trx) to generate Trx-PfPMVp37 and Trx-PfPMVm84. The fusion proteins were successfully purified using Ni(2+) affinity chromatography in combination with ATP treatment to eliminate Escherichia coli HSP60 contaminant. Trx-PfPMVm84 could hydrolyze the PEXEL-containing peptides more efficiently than Trx-PfPMVp37. Interestingly, both Trx-PfPMVs preferred to cleave PfEMP2 peptide over HRPII peptide. The replacement of Ser with Val or Glu at P1' position created a substrate with 75% reduction in the enzyme activity, whereas the substitution of Ile with Lys or Glu at P2 position reduced the cleavage efficiency by 30%. The activity of Trx-PfPMVm84 was inhibited by PMSF and nelfinavir but not by pepstatin A. After the removal of Trx domain, activities of both enzymes toward PfEMP2 and HRPII peptides were fitted to the Michaelis-Menten model to determine kinetic parameters. The Km values toward both peptides were apparently much lower than the previously reported data although with similar kcat values. Along with an improved PfPMV preparation protocol, these findings have provided insights into its substrate specificity at P2 and P1' positions as well as interactions among the enzyme, substrates, and inhibitors.

  17. Molecular make-up of the Plasmodium parasitophorous vacuolar membrane.

    Science.gov (United States)

    Spielmann, Tobias; Montagna, Georgina N; Hecht, Leonie; Matuschewski, Kai

    2012-10-01

    Plasmodium, the causative agent of malaria, is an obligate, intracellular, eukaryotic cell that invades, replicates, and differentiates within hepatocytes and erythrocytes. Inside a host cell, a second membrane delineates the developing pathogen in addition to the parasite plasma membrane, resulting in a distinct cellular compartment, termed parasitophorous vacuole (PV). The PV membrane (PVM) constitutes the parasite-host cell interface and is likely central to nutrient acquisition, host cell remodeling, waste disposal, environmental sensing, and protection from innate defense. Over the past two decades, a number of parasite-encoded PVM proteins have been identified. They include multigene families and protein complexes, such as early-transcribed membrane proteins (ETRAMPs) and the Plasmodium translocon for exported proteins (PTEX). Nearly all Plasmodium PVM proteins are restricted to this genus and display transient and stage-specific expression. Here, we provide an overview of the PVM proteins of Plasmodium blood and liver stages. Biochemical and experimental genetics data suggest that some PVM proteins are ideal targets for novel anti-malarial intervention strategies.

  18. Exporter Price Premia?

    DEFF Research Database (Denmark)

    Jäkel, Ina Charlotte; Sørensen, Allan

    -cut prediction on the sign of the exporter price premium. However, the model unambiguously predicts a negative exporter price premium in terms of quality-adjusted prices, i.e. prices per unit of quality. This prediction is broadly borne out in the Danish data: while the magnitude of the premium varies across...

  19. Industrialisation, Exports and Employment.

    Science.gov (United States)

    Sabolo, Yves

    1980-01-01

    After reviewing trends in industrial production, exports, and employment in the Third World since 1960, the author discusses industrialization strategies based on the local processing of raw materials for export. Such processing has proved to be a major factor in job creation. (Author/SK)

  20. Developing Refractories for Exporting

    Institute of Scientific and Technical Information of China (English)

    PANShang-xin

    1996-01-01

    The total output of China refractory products and export volume of China refractory raw materials rank the first in the world,In future the task is to improve the quality of the products to enlarge the variety and to expand export.

  1. Exports to Imports

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    China covers ground as it attempts to balance imports and exports after a trade deficit in the first quarter As China gears up to rebalance its economy,a key factor will be weaning its reliance on exports.The vigorous efforts are paying off as the country reported a trade deficit in the first

  2. Strong Support for Exporters

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ The sweeping international financial crisis has taken its toll on the Chinese economy,especially in the export sector.On the one hand,overseas demand has plummeted,while on the other,with the worsening credit environment and emerging trade protectionism,export enterprises are suffering from rising credit risks to the point where some dare not even accept orders.

  3. Markups and Exporting Behavior

    DEFF Research Database (Denmark)

    De Loecker, Jan; Warzynski, Frederic Michel Patrick

    2012-01-01

    estimates of plant- level markups without specifying how firms compete in the product market. We rely on our method to explore the relationship be- tween markups and export behavior. We find that markups are estimated significantly higher when controlling for unobserved productivity; that exporters charge...

  4. Development Strategy for the Export- Oriented Horticulture in Ethiopia

    NARCIS (Netherlands)

    Joosten, F.J.

    2007-01-01

    The export-oriented horticulture sector in Ethiopia has been growing rapidly and forms an important element in the country’s efforts to expand and diversify the economy, raise export earnings and create employment. This rapid growth is remarkable particularly when placed in a historic context. Furth

  5. Stable assembly of HIV-1 export complexes occurs cotranscriptionally

    DEFF Research Database (Denmark)

    Nawroth, Isabel; Mueller, Florian; Basyuk, Eugenia

    2014-01-01

    The HIV-1 Rev protein mediates export of unspliced and singly spliced viral transcripts by binding to the Rev response element (RRE) and recruiting the cellular export factor CRM1. Here, we investigated the recruitment of Rev to the transcription sites of HIV-1 reporters that splice either post- ...

  6. High export of dissolved silica from the Greenland Ice Sheet

    NARCIS (Netherlands)

    Meire, L.; Meire, P.; Struyf, E.; Krawczyk, D.W.; Arendt, K.E.; Yde, J.C.; Juul-Pedersen, T.; Hopwood, M. J.; Rysgaard, S.; Meysman, F.J.R.

    2016-01-01

    Silica is an essential element for marine life and plays a key role in the biogeochemistry ofthe ocean. Glacial activity stimulates rock weathering, generating dissolved silica that is exported tocoastal areas along with meltwater. The magnitude of the dissolved silica export from large glacial area

  7. High export of dissolved silica from the Greenland Ice Sheet

    NARCIS (Netherlands)

    Meire, L.; Meire, P.; Struyf, E.; Krawczyk, D.W.; Arendt, K.E.; Yde, J.C.; Juul-Pedersen, T.; Hopwood, M.J.; Rysgaard, S.; Meysman, F.J.R.

    2016-01-01

    Silica is an essential element for marine life and plays a key role in the biogeochemistry of the ocean. Glacial activity stimulates rock weathering, generating dissolved silica that is exported to coastal areas along with meltwater. The magnitude of the dissolved silica export from large glacial

  8. Mosquito transgenic technologies to reduce Plasmodium transmission.

    Science.gov (United States)

    Fuchs, Silke; Nolan, Tony; Crisanti, Andrea

    2013-01-01

    The ability to introduce genetic constructs of choice into the genome of Anopheles mosquitoes provides a valuable tool to study the molecular interactions between the Plasmodium parasite and its insect host. In the long term, this technology could potentially offer new ways to control vector-borne diseases through the suppression of target mosquito populations or through the introgression of traits that preclude pathogen transmission. Here, we describe in detail protocols for the generation of transgenic Anopheles gambiae mosquitoes based on germ-line transformation using either modified transposable elements or the site-specific PhiC31 recombinase.

  9. Diagnostics of the Enterprise Export Potential

    Directory of Open Access Journals (Sweden)

    Skrynkovskyy Ruslan M.

    2016-11-01

    Full Text Available The aim of the article is to form and develop theoretical and methodological foundations for diagnostics of the enterprise export potential, which should be understood as a process of identification, analysis and assessment of the level of potential possibility and readiness of the enterprise to implement export activities taking into account the impact of interrelated internal variables (goals, technology, structure, tasks, educational and professional potential of the staff and factors of the enterprise external environment (customers, competitors, suppliers, intermediaries, contact audience, etc. in order to ensure a qualitatively new level of its development and formation of its prospects. It is determined that the key business indicators of the system for diagnostics of enterprise export potential are: the level of enterprises competitiveness in the international (global market; the level of competitiveness of enterprise products; the level of competitiveness of enterprise export products; the level of enterprise resource opportunities; the level of enterprise export performance. Prospects for further research in this direction are to develop a classification (specifically detailed list of objectives of the enterprise diagnostics by the level of detail (element, partial, complex, taking into account diagnostics of export potential of the enterprise as part of diagnostic objective.

  10. Guide to software export

    CERN Document Server

    Philips, Roger A

    2014-01-01

    An ideal reference source for CEOs, marketing and sales managers, sales consultants, and students of international marketing, Guide to Software Export provides a step-by-step approach to initiating or expanding international software sales. It teaches you how to examine critically your candidate product for exportability; how to find distributors, agents, and resellers abroad; how to identify the best distribution structure for export; and much, much more!Not content with providing just the guidelines for setting up, expanding, and managing your international sales channels, Guide to Software

  11. 10 CFR 110.21 - General license for the export of special nuclear material.

    Science.gov (United States)

    2010-01-01

    ... per year to any one country. (2) Special nuclear material in fuel elements as replacements for damaged or defective unirradiated fuel elements previously exported under a specific license, subject to the same terms as the original export license and the condition that the replaced fuel elements must...

  12. Valie EXPORT Society Rooseumis

    Index Scriptorium Estoniae

    2002-01-01

    Malmös Rooseumi Kaasaegse Kunsti Keskuses näitus "Baltic Babel". Projekt koosneb Läänemeremaade linnades tegutsevate innovatiivsete gruppide aktsioonidest. Kuraator Charles Esche. Esinejatest (Eestist Valie Export Society: Kadi Estland, Killu Sukmit)

  13. Valie EXPORT Society. Overlok

    Index Scriptorium Estoniae

    2001-01-01

    Valie EXPORT Society asutasid 23. okt. 1999. a. Frankfurdis Kadi Estland, Killu Sukmit ja Mari Laanemets, kui olid külastanud austria naiskunstniku Valie Exporti näitust. Rühmituse aktsioonide kirjeldus

  14. Exporting Humanist Architecture

    DEFF Research Database (Denmark)

    Nielsen, Tom

    2016-01-01

    values and ethical stands involved in the export of Danish Architecture. Abstract: Danish architecture has, in a sense, been driven by an unwritten contract between the architects and the democratic state and its institutions. This contract may be viewed as an ethos – an architectural tradition...... with inherent aesthetic and moral values. Today, however, Danish architecture is also an export commodity. That raises questions, which should be debated as openly as possible. What does it mean for architecture and architects to practice in cultures and under political systems that do not use architecture...... as a way of generating humanism, freedom or equality? The essay outlines the background story, identifies a number of positions in relation to architecture exports and discusses some of the dilemmas that arise when Danish architecture is seen in an export perspective....

  15. Valie EXPORT Society Rooseumis

    Index Scriptorium Estoniae

    2002-01-01

    Malmös Rooseumi Kaasaegse Kunsti Keskuses näitus "Baltic Babel". Projekt koosneb Läänemeremaade linnades tegutsevate innovatiivsete gruppide aktsioonidest. Kuraator Charles Esche. Esinejatest (Eestist Valie Export Society: Kadi Estland, Killu Sukmit)

  16. Valie EXPORT Society. Overlok

    Index Scriptorium Estoniae

    2001-01-01

    Valie EXPORT Society asutasid 23. okt. 1999. a. Frankfurdis Kadi Estland, Killu Sukmit ja Mari Laanemets, kui olid külastanud austria naiskunstniku Valie Exporti näitust. Rühmituse aktsioonide kirjeldus

  17. Slowed Exports Growth

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ Ⅲ. Slowed export recovery in the second half Since the beginning of this year, global trade has maintained a recovery growth thanks to the worldwide economic rally.From January to April, the imports of three major Economics--the United States, the euro zone and Japan--rose 17.5 percent on average from a year ago. Import growths for the United States, the euro zone and Japan were 20.9 percent, 4.8 percent and 29 percent, respectively, which spurred China's exports to those regions. From January to June this year, China's exports totaled $705.09 billion, up 35.2 percent from the same period in 2009 and were 5.8 percent higher than the first half of 2008 when the crisis had yet to begin. Those figures indicated China's exports had rebounded to precrisis levels.

  18. Illegal Weapons Exports?

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Amnesty International, a human rights organization, released a report on June 11 accusing China of facilitating regional conflicts and human rights violations by exporting a large quantity of weapons to Sudan, Nepal, Myanmar and the Great Lakes countries of Africa. Responding to such charges, Teng Jianqun, a researcher with the China Arms Control and Disarmament Association, told the official Xinhua News Agency that China has always put its limited arms exports under strict control and surveillance, deno...

  19. Exploitative Learning by Exporting

    DEFF Research Database (Denmark)

    Golovko, Elena; Lopes Bento, Cindy; Sofka, Wolfgang

    Decisions on entering foreign markets are among the most challenging but also potentially rewarding strategy choices managers can make. In this study, we examine the effect of export entry on the firm investment decisions in two activities associated with learning about new technologies and learn......Decisions on entering foreign markets are among the most challenging but also potentially rewarding strategy choices managers can make. In this study, we examine the effect of export entry on the firm investment decisions in two activities associated with learning about new technologies...... and learning about new markets ? R&D investments and marketing investments, in search of novel insights into the content and process underlying learning by exporting. We draw from organizational learning theory for predicting changes in both R&D and marketing investment patterns that accompany firm entry...... into exporting and link these changes to firm productivity. Our results show that marketing investments are equally likely to be triggered by exporting as R&D investments. Furthermore, our results suggest that although export entry is accompanied by increases in both R&D and marketing expenditures...

  20. Export Taxes under Bertrand Duopoly

    OpenAIRE

    Clarke, Roger; Collie, David R.

    2006-01-01

    This article analyses export taxes in a Bertrand duopoly with product differentiation, where a home and a foreign firm both export to a third-country market. It is shown that the maximum-revenue export tax always exceeds the optimum-welfare export tax. In a Nash equilibrium in export taxes, the country with the low cost firm imposes the largest export tax. The results under Bertrand duopoly are compared with those under Cournot duopoly. It is shown that the absolute value of the export subsid...

  1. Multiple Export Mechanisms for mRNAs

    Science.gov (United States)

    Delaleau, Mildred; Borden, Katherine L. B.

    2015-01-01

    Nuclear mRNA export plays an important role in gene expression. We describe the mechanisms of mRNA export including the importance of mRNP assembly, docking with the nuclear basket of the nuclear pore complex (NPC), transit through the central channel of the NPC and cytoplasmic release. We describe multiple mechanisms of mRNA export including NXF1 and CRM1 mediated pathways. Selective groups of mRNAs can be preferentially transported in order to respond to cellular stimuli. RNAs can be selected based on the presence of specific cis-acting RNA elements and binding of specific adaptor proteins. The role that dysregulation of this process plays in human disease is also discussed. PMID:26343730

  2. ANALYTICAL APPROACHES TO THE STUDY OF EXPORT TRANSACTIONS

    Directory of Open Access Journals (Sweden)

    Ekaterina Viktorovna Medvedeva

    2015-12-01

    Full Text Available Analytical approaches to research of export operations depend on the conditions containing in separate external economic contracts with foreign buyers and also on a form of an exit of the Russian supplier of export goods to a foreign market. By means of analytical procedures it is possible to foresee and predict admissible situations which can have an adverse effect on a financial position of the economic subject. The economic entity, the engaged foreign economic activity, has to carry out surely not only the analysis of the current activity, but also the analysis of export operations. In article analytical approaches of carrying out the analysis of export operations are considered, on an example the analysis of export operations in dynamics is submitted, it is recommended to use the formulas allowing to estimate export in dynamics. For the comparative analysis export volume in the comparable prices is estimated. On the commodity groups including and quantitatively and qualitatively commensurable goods, the index of quantitative structure is calculated, the coefficient of delay of delivery of goods in comparison with other periods pays off. Carrying out the analysis allows to determine a tendency of change of export deliveries by export operations for the analyzed period for adoption of administrative decisions.Purpose Definition of the ways and receptions of the analysis applying when carrying out the analysis of export operations.Methodology in article economic-mathematical methods, and also statistical methods of the analysis were used.Results: the most informative parameters showing some aspects of carrying out the analysis of export operations are received.Practical implications it is expedient to apply the received results the economic subjects which are carrying out foreign economic activity, one of which elements are export operations.

  3. Composition of Exports and Export Performance of Eurozone Countries

    NARCIS (Netherlands)

    Wierts, Peter; Van Kerkhoff, Henk; De Haan, Jakob

    2014-01-01

    This article investigates to what extent the composition of exports is related to the export performance of eurozone countries using a data set on exports from the oldest eurozone countries to their top 20 trade partners for the period 1988-2009. The results suggest that a higher share of high techn

  4. 77 FR 69789 - President's Export Council Subcommittee on Export Administration; Notice of Partially Closed Meeting

    Science.gov (United States)

    2012-11-21

    ... Bureau of Industry and Security President's Export Council Subcommittee on Export Administration; Notice of Partially Closed Meeting The President's Export Council Subcommittee on Export Administration... PECSEA provides advice on matters pertinent to those portions of the Export Administration Act,...

  5. Exporting to Russia?

    DEFF Research Database (Denmark)

    Thomsen, Lotte

    2016-01-01

    This article draws on extensive fieldwork conducted in Central Asia to explore food exports to Russia. It takes its theoretical starting point in global value chain theory and pinpoints chain entry barriers relating to financing, transportation and standards. The article also proposes rethinking...

  6. China Reshuffles Export Incentives

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    What it means for China's economy... Last month, the Chinese Government made sweeping changes to the export tax breaks that domestic companies receive. Here's what happened: On September 14, the Ministry of Finance, the General Administration of Customs, the National Development and Reform Commission, the Ministry of

  7. Export Restructuring on Rebates Change

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Again, the Chinese governmenthas recently adjusted the export tax rebates upon 2831 categories of goods, accounting for 37% of the nation's total export products. Export rebates on most products have decreased by 2% to 4%, and some have had an even steeper reduction. For instance,the export tax rebate has plummeted from 11% or 13% to zero on cement and chemical products, which are called "high-energy-consumption.

  8. 21 CFR 866.3402 - Plasmodium species antigen detection assays.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Plasmodium species antigen detection assays. 866... Plasmodium species antigen detection assays. (a) Identification. A Plasmodium species antigen detection assay... malaria caused by the four malaria species capable of infecting humans: Plasmodium falciparum, Plasmodium...

  9. Plasmodium vivax: who cares?

    Directory of Open Access Journals (Sweden)

    Barnwell John W

    2008-12-01

    Full Text Available Abstract More attention is being focused on malaria today than any time since the world's last efforts to achieve eradication over 40 years ago. The global community is now discussing strategies aimed at dramatically reducing malarial disease burden and the eventual eradication of all types of malaria, everywhere. As a consequence, Plasmodium vivax, which has long been neglected and mistakenly considered inconsequential, is now entering into the strategic debates taking place on malaria epidemiology and control, drug resistance, pathogenesis and vaccines. Thus, contrary to the past, the malaria research community is becoming more aware and concerned about the widespread spectrum of illness and death caused by up to a couple of hundred million cases of vivax malaria each year. This review brings these issues to light and provides an overview of P. vivax vaccine development, then and now. Progress had been slow, given inherent research challenges and minimal support in the past, but prospects are looking better for making headway in the next few years. P. vivax, known to invade the youngest red blood cells, the reticulocytes, presents a strong challenge towards developing a reliable long-term culture system to facilitate needed research. The P. vivax genome was published recently, and vivax researchers now need to coordinate efforts to discover new vaccine candidates, establish new vaccine approaches, capitalize on non-human primate models for testing, and investigate the unique biological features of P. vivax, including the elusive P. vivax hypnozoites. Comparative studies on both P. falciparum and P. vivax in many areas of research will be essential to eradicate malaria. And to this end, the education and training of future generations of dedicated "malariologists" to advance our knowledge, understanding and the development of new interventions against each of the malaria species infecting humans also will be essential.

  10. 75 FR 52453 - Entry Requirements for Certain Softwood Lumber Products Exported From Any Country Into the United...

    Science.gov (United States)

    2010-08-26

    ... Canadian-issued export permits often present the export price as an aggregate figure. Presenting this data... common data elements that are submitted to both the U.S. and Canada should be the same. Therefore data... which would create discrepancies between the export permit date and the entry summary data....

  11. The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA.

    Science.gov (United States)

    Booth, David S; Cheng, Yifan; Frankel, Alan D

    2014-12-08

    The HIV Rev protein routes viral RNAs containing the Rev Response Element (RRE) through the Crm1 nuclear export pathway to the cytoplasm where viral proteins are expressed and genomic RNA is delivered to assembling virions. The RRE assembles a Rev oligomer that displays nuclear export sequences (NESs) for recognition by the Crm1-Ran(GTP) nuclear receptor complex. Here we provide the first view of an assembled HIV-host nuclear export complex using single-particle electron microscopy. Unexpectedly, Crm1 forms a dimer with an extensive interface that enhances association with Rev-RRE and poises NES binding sites to interact with a Rev oligomer. The interface between Crm1 monomers explains differences between Crm1 orthologs that alter nuclear export and determine cellular tropism for viral replication. The arrangement of the export complex identifies a novel binding surface to possibly target an HIV inhibitor and may point to a broader role for Crm1 dimerization in regulating host gene expression.

  12. Antibodies and Plasmodium falciparum merozoites

    NARCIS (Netherlands)

    Ramasamy, R; Ramasamy, M; Yasawardena, S

    There is considerable interest in using merozoite proteins in a vaccine against falciparum malaria. Observations that antibodies to merozoite surface proteins block invasion are a basis for optimism. This article draws attention to important and varied aspects of how antibodies to Plasmodium

  13. Risk Taking Propensity and Export Performance of Croatian Exporters

    Directory of Open Access Journals (Sweden)

    Mirna Leko-Simic

    2006-12-01

    Full Text Available Export performance is today one of the most widely used measures of a company’s success, due to the globalization and market liberalization processes. The rather bad export performance of Croatian exporters can be explained by a number of factors, one of which is assumed to be the low level of risk taking propensity, which is one of the three major dimensions of entrepreneurial behavior. The aim of this paper is to analyze company age, size and type of business as determinants of risk taking propensity in Croatian exporting companies. Cluster analysis based on four variable criteria was used in order to determine risk and non-risk takers’ clusters and analyze the significant differences between them in relation to their export performance. The paper is based on research of 88 Croatian exporters.

  14. An Anatomy Of The Export Expansion Process

    OpenAIRE

    Reid, S

    1986-01-01

    This paper examines the export market strategies and export modes used by small and medium sized Italian manufacturing firms. The firms vary extensively in their extent and type of export dependence on different channel arrangements and export markets. Moreover, the exporting modes used do show some peculiar links with export objectives specifically higher dependence on direct sales is associated with planned export expansion and higher dependence on agent/representatives and distributors is ...

  15. China's Export Expansion, Export Structure and Energy Consumption

    Institute of Scientific and Technical Information of China (English)

    Lan Yisheng; Ning Xuemin

    2011-01-01

    Since the reform and opening up, China's export trade has maintained a rapid growth; meanwhile, China's energy consumption has been increasing sharply. "High export and high energy consumption" has become the feature of China's trade and economic development. In this paper, based on the input-output analysis approach, the authors have conducted an empirical study on the export trade and energy consumption of 21 trade industrial sectors. The results show that, China is a big net exporter of embodied energy. Assuming that the export growth rate of embodied energy maintains to be about 23.6%, the average annual growth rate of the past 32 years, and based on the input-output data of 2005, by 2030 China's net export of embodied energy would be over eight times more than the aggregate energy production, which is obviously infeasible. As a country of very low per capita en- ergy, China must change its export pattern, encourage or restrain the export of different industrial sectors according to their energy consumption intensity, and promote structural change of energy- efficient exported products, so as to achieve the sustainable development. Accordingly, the authors put forward some suggestions.

  16. Genetic diversity of Plasmodium vivax and Plasmodium falciparum in Honduras

    Directory of Open Access Journals (Sweden)

    Lopez Ana

    2012-11-01

    Full Text Available Abstract Background Understanding the population structure of Plasmodium species through genetic diversity studies can assist in the design of more effective malaria control strategies, particularly in vaccine development. Central America is an area where malaria is a public health problem, but little is known about the genetic diversity of the parasite’s circulating species. This study aimed to investigate the allelic frequency and molecular diversity of five surface antigens in field isolates from Honduras. Methods Five molecular markers were analysed to determine the genotypes of Plasmodium vivax and Plasmodium falciparum from endemic areas in Honduras. Genetic diversity of ama-1, msp-1 and csp was investigated for P. vivax, and msp-1 and msp-2 for P. falciparum. Allelic frequencies were calculated and sequence analysis performed. Results and conclusion A high genetic diversity was observed within Plasmodium isolates from Honduras. A different number of genotypes were elucidated: 41 (n = 77 for pvama-1; 23 (n = 84 for pvcsp; and 23 (n = 35 for pfmsp-1. Pvcsp sequences showed VK210 as the only subtype present in Honduran isolates. Pvmsp-1 (F2 was the most polymorphic marker for P. vivax isolates while pvama-1 was least variable. All three allelic families described for pfmsp-1 (n = 30 block 2 (K1, MAD20, and RO33, and both allelic families described for the central domain of pfmsp-2 (n = 11 (3D7 and FC27 were detected. However, K1 and 3D7 allelic families were predominant. All markers were randomly distributed across the country and no geographic correlation was found. To date, this is the most complete report on molecular characterization of P. vivax and P. falciparum field isolates in Honduras with regards to genetic diversity. These results indicate that P. vivax and P. falciparum parasite populations are highly diverse in Honduras despite the low level of transmission.

  17. High export of dissolved silica from the Greenland Ice Sheet

    Science.gov (United States)

    Meire, L.; Meire, P.; Struyf, E.; Krawczyk, D. W.; Arendt, K. E.; Yde, J. C.; Juul Pedersen, T.; Hopwood, M. J.; Rysgaard, S.; Meysman, F. J. R.

    2016-09-01

    Silica is an essential element for marine life and plays a key role in the biogeochemistry of the ocean. Glacial activity stimulates rock weathering, generating dissolved silica that is exported to coastal areas along with meltwater. The magnitude of the dissolved silica export from large glacial areas such as the Greenland Ice Sheet is presently poorly quantified and not accounted for in global budgets. Here we present data from two fjord systems adjacent to the Greenland Ice Sheet which reveal a large export of dissolved silica by glacial meltwater relative to other macronutrients. Upscaled to the entire Greenland Ice Sheet, the export of dissolved silica equals 22 ± 10 Gmol Si yr-1. When the silicate-rich meltwater mixes with upwelled deep water, either inside or outside Greenland's fjords, primary production takes place at increased silicate to nitrate ratios. This likely stimulates the growth of diatoms relative to other phytoplankton groups.

  18. NEW APPROACHES TO EXPORT COMPETITIVENESS

    OpenAIRE

    Alina Petronela NEGREA

    2015-01-01

    The economic literature and the political discourse typically look at international competitiveness mainly by the means of export market shares. However, globalisation, production fragmentation and the growing importance of global value chains (GVCs) increasingly challenge traditional approaches of export competitiveness and call for a more accurate and disaggregated level of analysis. Due to the growing fragmentation of production, a country exports now include a significant amount of import...

  19. Minimum quality standards and exports

    OpenAIRE

    2015-01-01

    This paper studies the interaction of a minimum quality standard and exports in a vertical product differentiation model when firms sell global products. If ex ante quality of foreign firms is lower (higher) than the quality of exporting firms, a mild minimum quality standard in the home market hinders (supports) exports. The minimum quality standard increases quality in both markets. A welfare maximizing minimum quality standard is always lower under trade than under autarky. A minimum quali...

  20. Soviet energy export prospects

    Energy Technology Data Exchange (ETDEWEB)

    Scanlan, Tony

    1991-05-01

    The Soviet Union produces 20% of world energy but since 1988 this is in decline. Awakening consumerism and a sea-change in the structure of foreign trade and internal investment are placing this key industry into unprecedented uncertainty. The difference between success and failure goes beyond the 1988 peak of six million barrels daily of exports in oil equivalent. The article quantifies the key areas of energy uncertainty as equal in volume to total OPEC output and sees the long-term changes of success more than ever dependent on coordinated planning and investment as well as on market reality. (Author).

  1. Slowed Exports Growth

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    The first half of 2010 is showing that the impacts of the financial crisis are still lingering.Zhao Jinping,a researcher at the Development Research Center of the State Council,says that the possible implementation of exit strategies in developed countries may deal a heavy blow to a global rally,and it will certainly result in slowed exports growth for China.Zhao published his opinion in the China Economic Times.The first part was published in issue No.33.Edited excerpts of the second part follow:

  2. Exporting to Russia?

    DEFF Research Database (Denmark)

    Thomsen, Lotte

    2016-01-01

    This article draws on extensive fieldwork conducted in Central Asia to explore food exports to Russia. It takes its theoretical starting point in global value chain theory and pinpoints chain entry barriers relating to financing, transportation and standards. The article also proposes rethinking...... the aspects of territoriality and institutional context, and suggests their integration into one concept, or rather a process of contextualizing territories. In doing so, the article argues for a methodology that not only examines current events, but also captures change as particularly important in what we...

  3. Mozambique. Export perespectives

    Directory of Open Access Journals (Sweden)

    Joanna Sitz-Kuleszo

    2014-09-01

    Full Text Available Destroyed by wars, military and internal conflicts economy of Republic of Mozambique since more than a decade is constantly growing. This 36th biggest country in the world became the object of interest for investment and trade for many developed economies, mostly from Asia. Nowadays investments in Mozambique are focused mostly on rich carbon and gas sources that has been discovered during last decade. Poland is not important trade partner for Mozambique, however could intensify exchange in upcoming years as, if the development will continue, Republic of Mozambique would need for its economy Polish export specialties.

  4. Protein export through the bacterial flagellar type III export pathway.

    Science.gov (United States)

    Minamino, Tohru

    2014-08-01

    For construction of the bacterial flagellum, which is responsible for bacterial motility, the flagellar type III export apparatus utilizes both ATP and proton motive force across the cytoplasmic membrane and exports flagellar proteins from the cytoplasm to the distal end of the nascent structure. The export apparatus consists of a membrane-embedded export gate made of FlhA, FlhB, FliO, FliP, FliQ, and FliR and a water-soluble ATPase ring complex consisting of FliH, FliI, and FliJ. FlgN, FliS, and FliT act as substrate-specific chaperones that do not only protect their cognate substrates from degradation and aggregation in the cytoplasm but also efficiently transfer the substrates to the export apparatus. The ATPase ring complex facilitates the initial entry of the substrates into the narrow pore of the export gate. The export gate by itself is a proton-protein antiporter that uses the two components of proton motive force, the electric potential difference and the proton concentration difference, for different steps of the export process. A specific interaction of FlhA with FliJ located in the center of the ATPase ring complex allows the export gate to efficiently use proton motive force to drive protein export. The ATPase ring complex couples ATP binding and hydrolysis to its assembly-disassembly cycle for rapid and efficient protein export cycle. This article is part of a Special Issue entitled: Protein trafficking and secretion in bacteria. Guest Editors: Anastassios Economou and Ross Dalbey. © 2013 Elsevier B.V. All rights reserved.

  5. 78 FR 37785 - Order Denying Export Privileges

    Science.gov (United States)

    2013-06-24

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Gerardo Domingo... Domingo Rodriguez-Rivera (``Rodriguez-Rivera'') was convicted of violating Section 38 of the ] Arms Export... convicted of knowingly and willfully exporting and causing to be exported and attempting to export...

  6. Complement evasion by Plasmodium falciparum

    OpenAIRE

    Holopainen, Saila

    2008-01-01

    Patologian oppiaine Malaria remains one of the major health problems in many tropical countries, especially in sub-Saharan Africa. Among the most characteristic features of the malaria pathogens, protozoan parasites of the genus Plasmodium, is their ability to evade the immune defences of the host for extended periods of time. The complement system (C) is an essential part of the innate system in the first line of defense. It consists of over 30 soluble or membrane-bound components. C...

  7. Tetany with Plasmodium falciparum infection.

    Science.gov (United States)

    Singh, P S; Singh, Neha

    2012-07-01

    Plasmodium falciparum is a malarial infection with high morbidity and wide spectrum of atypical presentation. Here we report an unusual presentation of malaria as tetany with alteration in calcium,phosphate and magnesium metabolism Hypocalcaemia in malaria can cause prolonged Q-Tc interval which could be arisk factor for quinine cardiotoxicity and sudden death Hence monitoring of serum calcium in severe malarial infection and cautious use of quinine in such patients is very important in management

  8. Export incentives, exchange rate policy and export growth in Turkey

    NARCIS (Netherlands)

    S.J.G. van Wijnbergen; I. Arslan

    1993-01-01

    The driving forces behind the Turkish export miracle, and in fact its very existence, have remained a matter of debate We show there was a boom. As to contributing factors, import growth in the Middle East in excess of import growth elsewhere made a negative contribution. On exports to non-oil count

  9. Export incentives, exchange rate policy and export growth in Turkey

    NARCIS (Netherlands)

    van Wijnbergen, S.J.G.; Arslan, I.

    1993-01-01

    The driving forces behind the Turkish export miracle, and in fact its very existence, have remained a matter of debate We show there was a boom. As to contributing factors, import growth in the Middle East in excess of import growth elsewhere made a negative contribution. On exports to non-oil

  10. Informal export barriers and poverty

    OpenAIRE

    Porto, Guido G.

    2004-01-01

    The author investigates the poverty impacts of informal export barriers like transport costs, cumbersome customs practices, costly regulations, and bribes. He models these informal barriers as export taxes that distort the efficient allocation of resources. In low-income agricultural economies, this distortion lowers wages and household agricultural income, thereby leading to higher pover...

  11. Tumbling Auto Import and Export

    Institute of Scientific and Technical Information of China (English)

    Yantai Chen

    2009-01-01

    @@ The seemingly rebound global financial crisis has seriously eroded world economy from 2008,of which China's tumbling auto imports and exports business is a good example.At the beginning of 2008 it kicked off as an excellent year for the Chinese automotive market,but ended with the onset of a recession in last quarter both from the perspective of import and export.

  12. Insurability of export credit risks

    NARCIS (Netherlands)

    Alsem, K.J.; Antufjew, J.; Huizingh, K.R.E.; Koning, Ruud H.; Sterken, E.; Woltil, M.

    2003-01-01

    Firms exporting their goods and services abroad face risks that are different from the risks faced by firms who do not engage in international trade. It is common practice to allow the receiving party to pay in instalments. The exporting firm faces credit risk, but as in most countries, Dutch firms

  13. Insurability of export credit risks

    NARCIS (Netherlands)

    Alsem, K.J.; Antufjew, J.; Huizingh, K.R.E.; Koning, Ruud H.; Sterken, E.; Woltil, M.

    2003-01-01

    Firms exporting their goods and services abroad face risks that are different from the risks faced by firms who do not engage in international trade. It is common practice to allow the receiving party to pay in instalments. The exporting firm faces credit risk, but as in most countries, Dutch firms

  14. The south's timer export potential

    Science.gov (United States)

    James E. Granskog

    1986-01-01

    Exports of southern wood products have bccil dcclirling since 1980, following a dramatic rise during the 1970s. The value of these exports rose from near the $50 million level in the early 1970s to almost $500 million in 1980, but has dropped by more than a third since then. Now, however, changing monetary conditions appear to be turning the trend upward again....

  15. Sinosure Helping to Stabilize Exports

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The unfolding international financial crisis is taking its toll on China’s economy, especially China’s exports. On one hand, overseas demand has plummeted, while on the other, with the worsening credit environment and emerging trade protectionism, export enter-prises are suffering from rising credit risks, to the point where some of them dare not even accept orders.

  16. Great Challenge in Steel Export

    Institute of Scientific and Technical Information of China (English)

    Charlsea Liu

    2009-01-01

    @@ In 2008, the export of China steel products experienoeu, a splendid period f fast growing, and then disappointedly followed by fast depression. Until lest December, China in 2008 exported steel products of 59.21 million tons, less than the same term in 2007 by 3.48 million tons, declining about 5.6%.

  17. MRP1 mediates folate transport and antifolate sensitivity in Plasmodium falciparum.

    Science.gov (United States)

    Rijpma, Sanna R; van der Velden, Maarten; Bilos, Albert; Jansen, Robert S; Mahakena, Sunny; Russel, Frans G M; Sauerwein, Robert W; van de Wetering, Koen; Koenderink, Jan B

    2016-02-01

    Multidrug resistance-associated proteins (MRP) of Plasmodium falciparum have been associated with altered drug sensitivity. Knowledge on MRP substrate specificity is indispensible for the characterization of resistance mechanisms and identifying its physiological roles. An untargeted metabolomics approach detected decreased folate concentrations in red blood cells infected with schizont stage parasites lacking expression of MRP1. Furthermore, a tenfold decrease in sensitivity toward the folate analog methotrexate was detected for parasites lacking MRP1. PfMRP1 is involved in the export of folate from parasites into red blood cells and is therefore a relevant factor for efficient malaria treatment through the folate pathway.

  18. Detection of Plasmodium sp. in capybara.

    Science.gov (United States)

    dos Santos, Leonilda Correia; Curotto, Sandra Mara Rotter; de Moraes, Wanderlei; Cubas, Zalmir Silvino; Costa-Nascimento, Maria de Jesus; de Barros Filho, Ivan Roque; Biondo, Alexander Welker; Kirchgatter, Karin

    2009-07-07

    In the present study, we have microscopically and molecularly surveyed blood samples from 11 captive capybaras (Hydrochaeris hydrochaeris) from the Sanctuary Zoo for Plasmodium sp. infection. One animal presented positive on blood smear by light microscopy. Polymerase chain reaction was carried out accordingly using a nested genus-specific protocol, which uses oligonucleotides from conserved sequences flanking a variable sequence region in the small subunit ribosomal RNA (ssrRNA) of all Plasmodium organisms. This revealed three positive animals. Products from two samples were purified and sequenced. The results showed less than 1% divergence between the two capybara sequences. When compared with GenBank sequences, a 55% similarity was obtained to Toxoplasma gondii and a higher similarity (73-77.2%) was found to ssrRNAs from Plasmodium species that infect reptile, avian, rodents, and human beings. The most similar Plasmodium sequence was from Plasmodium mexicanum that infects lizards of North America, where around 78% identity was found. This work is the first report of Plasmodium in capybaras, and due to the low similarity with other Plasmodium species, we suggest it is a new species, which, in the future could be denominated "Plasmodium hydrochaeri".

  19. NEW APPROACHES TO EXPORT COMPETITIVENESS

    Directory of Open Access Journals (Sweden)

    Alina Petronela NEGREA

    2015-04-01

    Full Text Available The economic literature and the political discourse typically look at international competitiveness mainly by the means of export market shares. However, globalisation, production fragmentation and the growing importance of global value chains (GVCs increasingly challenge traditional approaches of export competitiveness and call for a more accurate and disaggregated level of analysis. Due to the growing fragmentation of production, a country exports now include a significant amount of imports of intermediate goods which are part of the export value. In this case, a simple analysis of the evolution of exports can distort the international competitive position of a country. The article suggests a new approach based on the value-added content of international trade measured by means of global value chain analysis.

  20. Second Thoughts on Exporter Productivity

    DEFF Research Database (Denmark)

    Sørensen, Allan; Schröder, Philipp J.H.

    Empirical literature has established a positive link between firm productivity and export status, yet notable exceptions exist. The present paper shows that the underlying theory (Melitz, 2003) is in fact able to accommodate the rule as well as the exception. The fulcrum of the argument is the te......Empirical literature has established a positive link between firm productivity and export status, yet notable exceptions exist. The present paper shows that the underlying theory (Melitz, 2003) is in fact able to accommodate the rule as well as the exception. The fulcrum of the argument...... is the tension between empirical work measuring productivity based on average cost information, and theoretical work representing productivity by marginal cost. In a heterogeneous firms trade model, we compute productivity based on average cost and find that around the export-indifferent firm, exporters...... will be less productive than non-exporters. Furthermore, we show that this effect may feed through at the industry level....

  1. NEW APPROACHES TO EXPORT COMPETITIVENESS

    Directory of Open Access Journals (Sweden)

    Alina Petronela NEGREA

    2015-04-01

    Full Text Available The economic literature and the political discourse typically look at international competitiveness mainly by the means of export market shares. However, globalisation, production fragmentation and the growing importance of global value chains (GVCs increasingly challenge traditional approaches of export competitiveness and call for a more accurate and disaggregated level of analysis. Due to the growing fragmentation of production, a country exports now include a significant amount of imports of intermediate goods which are part of the export value. In this case, a simple analysis of the evolution of exports can distort the international competitive position of a country. The article suggests a new approach based on the value-added content of international trade measured by means of global value chain analysis.

  2. Exporting EU Liberalism Eastwards

    Directory of Open Access Journals (Sweden)

    Lynn M. Tesser

    2009-07-01

    Full Text Available There is much more to liberalism in the post communist context than has been acknowledged. A sizeable effort has indeed emerged to transplant a relatively coherent liberal ideology to the region, one exported not merely through the conditionality of international financial institutions, but also through the conditionality and socialization of organizations like the NATO, OSCE, EU, and the Council of Europe. ‘EU liberalism’ includes the ‘standard’ liberal emphasis on individual rights, the rule of law, constitutional democracy, freedom, and market economics as well as support for minority rights, and a seemingly schizophrenic emphasis on economic integration that involves, first bringing down borders for the free movement of people, goods, capital, and services between member states, and second, market regulation to diminish the social downsides of capitalism. This paper outlines EU liberalism’s emergence and its application to Central and East European countries.

  3. On Overinvoicing of Exports in Pakistan

    OpenAIRE

    Zafar Mahmood; Mohammad Azhar

    2001-01-01

    Whereas the policy incentives were designed to promote exports from Pakistan, the incentive system instead led to illicit export practices, i.e., export overinvoicing due to the weaknesses of implementation. Such practices resulted in a significant financial loss to the country and undermined the effectiveness of the export-promoting policy. This paper has determined the presence of overinvoicing of exports in Pakistan and the geographic and product-wise patterns in export overinvoicing. The ...

  4. The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs

    DEFF Research Database (Denmark)

    Joergensen, Lars M; Salanti, Ali; Dobrilovic, Tina

    2010-01-01

    ABSTRACT: BACKGROUND: Infected humans make protective antibody responses to the PfEMP1 adhesion antigens exported by Plasmodium falciparum parasites to the erythrocyte membrane, but little is known about the kinetics of this antibody-receptor binding reaction or how the topology of PfEMP1 on the ...

  5. Exporting calcium from cells.

    Science.gov (United States)

    Guerini, Danilo; Coletto, Luisa; Carafoli, Ernesto

    2005-01-01

    All eukaryotic cells import Ca2+ through a number of variously gated plasma membrane channels. Once inside cells, Ca2+ transmits information to a large number of (enzyme) targets. Eventually, it must be exported again, to prevent the overloading of the cytosol with Ca2+. Two systems export Ca2+ from cells: a high affinity, low capacity Ca2+-ATPase, and a lower affinity, but much larger capacity, Na+/Ca2+ exchanger. The ATPase (commonly called the Ca2+ pump) is the fine-tuner of cell Ca2+, as it functions well even if the concentration of the ion drops below the microM level. It is a large enzyme, with 10 transmembrane domains and a C-terminal cytosolic tail that contains regulatory sites, including a calmodulin-binding domain. Four distinct gene products plus a large number of splice variants have been described. Some are tissue specific, the isoform 2 being specifically expressed in the sensorial cells of the Corti organ in the inner-ear. Its genetic absence causes deafness in mice. Two different families of the Na+/Ca2+ exchanger exist, one of which, originally described in photoreceptors, transports K+ and Ca2+ in exchange for Na+. The exchanger is particularly active in excitable cells, e.g., heart, where the necessity cyclically arises to rapidly eject large amounts of Ca2+. In addition to heart, the exchanger is particularly important to neurons: the cleavage of the most important neuronal isoform (NCX3) by calpains activated by excitotoxic treatments generates Ca2+ overload and eventually cell death.

  6. Plasmodium vivax malaria: An unusual presentation

    Directory of Open Access Journals (Sweden)

    Kasliwal Prasad

    2009-01-01

    Full Text Available Acute renal failure, disseminated intravascular coagulation (DIC, acute respiratory distress syndrome (ARDS, hypoglycemia, coma, or epileptic seizures are manifestations of severe Plasmodium falciparum malaria. On the other hand, Plasmodium vivax malaria seldom results in pulmonary damage, and pulmonary complications are exceedingly rare. We report the case of a 42-year-old male living in a malaria-endemic area who presented with ARDS and was diagnosed as having Plasmodium vivax malaria. A diagnosis of Plasmodium vivax malaria was established by a positive Plasmodium LDH immunochromatographic assay while a negative PfHRP2 based assay ruled out P. falciparum malaria. After specific anti-plasmodial therapy and intensive supportive care, the patient recovered and was discharged from hospital. The use of NIPPV in vivax-malaria related ARDS was associated with a good outcome.

  7. Examining the role of export competitive advantages on export performance

    Directory of Open Access Journals (Sweden)

    Yeganeh Alimohammadi

    2014-04-01

    Full Text Available This paper investigates the role of export competitive advantage on export performance in food industry. The proposed study designs a questionnaire in Likert scale and distributes it among 280 randomly selected experts in food industry and Cronbach alpha has been calculated as 0.827. The study has applied factor analysis to find important factors influencing export performance. Kaiser-Meyer-Olkin Measure of Sampling Adequacy and Bartlett's Test of Sphericity have been performed to validate the results and they both validated the questionnaire. The results of the survey have determined six effective groups including product development, e-commerce, marketing planning, organizational performance, competitiveness and supply chain management.

  8. Control of Plasmodium knowlesi malaria

    Science.gov (United States)

    Abdullahi, Mohammed Baba; Hasan, Yahya Abu; Abdullah, Farah Aini

    2015-10-01

    The most significant and efficient measures against Plasmodium knowlesi outbreaks are efficient anti malaria drug, biological control in form of predatory mosquitoes and culling control strategies. In this paper optimal control theory is applied to a system of ordinary differential equation. It describes the disease transmission and Pontryagin's Maximum Principle is applied for analysis of the control. To this end, three control strategies representing biological control, culling and treatment were incorporated into the disease transmission model. The simulation results show that the implementation of the combination strategy during the epidemic is the most cost-effective strategy for disease transmission.

  9. The periodicity of Plasmodium vivax and Plasmodium falciparum in Venezuela.

    Science.gov (United States)

    Grillet, María-Eugenia; El Souki, Mayida; Laguna, Francisco; León, José Rafael

    2014-01-01

    We investigated the periodicity of Plasmodium vivax and P. falciparum incidence in time-series of malaria data (1990-2010) from three endemic regions in Venezuela. In particular, we determined whether disease epidemics were related to local climate variability and regional climate anomalies such as the El Niño Southern Oscillation (ENSO). Malaria periodicity was found to exhibit unique features in each studied region. Significant multi-annual cycles of 2- to about 6-year periods were identified. The inter-annual variability of malaria cases was coherent with that of SSTs (ENSO), mainly at temporal scales within the 3-6 year periods. Additionally, malaria cases were intensified approximately 1 year after an El Niño event, a pattern that highlights the role of climate inter-annual variability in the epidemic patterns. Rainfall mediated the effect of ENSO on malaria locally. Particularly, rains from the last phase of the season had a critical role in the temporal dynamics of Plasmodium. The malaria-climate relationship was complex and transient, varying in strength with the region and species. By identifying temporal cycles of malaria we have made a first step in predicting high-risk years in Venezuela. Our findings emphasize the importance of analyzing high-resolution spatial-temporal data to better understand malaria transmission dynamics. Copyright © 2013 Elsevier B.V. All rights reserved.

  10. 2006 Rare Earth Export Quota

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ According to correlative stipulations in "Goods Import εt Export Administrating Statute of P.R.C", 2006export quota for important industrial products was issued by the Ministry of Commerce of P.R.C. on December 30th of 2005. Export quota of rare earth products is 45,000 tons. It is said the quota will be distributed in two batches. The first batch of quota will reach 70-80% of the total with 21,700 - 24,800tons for domestic companies and 10,500 - 12,000 tons for foreign invested companies. Quota will be distributed to relevant enterprises directly in recent days.

  11. Learning to export and learning by exporting: The case of Ethiopian manufacturing

    OpenAIRE

    Siba, Eyerusalem; Gebreeyesus, Mulu

    2014-01-01

    In this study, we investigate the relationship between exporting and firm performance using a longer panel dataset of Ethiopian manufacturing firms for the period 1996 - 2009. We test two hypotheses regarding exporting: selection into exporting versus learning by exporting. According to the selection into exporting hypothesis, more productive firms self-select into exporting due to high entry costs. The learning by exporting hypothesis, on the other hand, emphasizes that firms learn after ent...

  12. Exports reflect "safety of products"

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Most of the made-in-China products are absolutely safe, and the steady increase in exports despite the recent widespread criticism reflects their safety standards, a Ministry of Commerce official said Thursday.

  13. Multidrug-exporting secondary transporters.

    Science.gov (United States)

    Murakami, Satoshi; Yamaguchi, Akihito

    2003-08-01

    The major cause of intrinsic drug resistance in Gram-negative bacteria is a resistance nodulation division type multidrug exporter, which couples with an outer membrane channel and a membrane fusion protein and exports drugs out of the cell, bypassing the periplasm; this process is driven by proton motive force. A recent crystal structure determination of a major resistance nodulation division type multidrug exporter, AcrB in Escherichia coli, greatly advances our understanding of the multidrug export mechanism. The most striking feature of the AcrB trimer is the presence of three vestibules open to the periplasm at the boundary between the periplasmic headpiece and the transmembrane region. Substrates can gain access to the central cavity from the periplasmic surface of the cytoplasmic membrane and are then actively transported through the extramembrane pore into the outer membrane channel TolC, via the funnel at the top of the AcrB headpiece.

  14. 75 FR 12433 - National Export Initiative

    Science.gov (United States)

    2010-03-16

    ... Enterprises (SMEs). Members of the Export Promotion Cabinet shall develop programs, in consultation with the TPCC, designed to enhance export assistance to SMEs, including programs that improve information and other technical assistance to first-time exporters and assist current exporters in identifying...

  15. 40 CFR 273.40 - Exports.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Exports. 273.40 Section 273.40... UNIVERSAL WASTE MANAGEMENT Standards for Large Quantity Handlers of Universal Waste § 273.40 Exports. A... exporter in 40 CFR 262.53, 262.56(a)(1) through (4), (6), and (b) and 262.57; (b) Export such...

  16. FDI as an Export-Platform

    DEFF Research Database (Denmark)

    Hajderllari, Luljeta; Karantininis, Konstantinos; Lawson, Lartey Godwin

    towards countries with large exports of agri-food, thereby supporting the hypothesis that FDI is used as an export-platform. FDI is coupled with high exports from Denmark, probably of raw or semi-processed food products for further processing and exports. We also find that FDI is higher in countries...

  17. 40 CFR 273.20 - Exports.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Exports. 273.20 Section 273.20... UNIVERSAL WASTE MANAGEMENT Standards for Small Quantity Handlers of Universal Waste § 273.20 Exports. A... exporter in 40 CFR 262.53, 262.56(a) (1) through (4), (6), and (b) and 262.57; (b) Export such...

  18. 27 CFR 28.30 - Export status.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export status. 28.30... Export status. (a) Distilled spirits and wines manufactured, produced, bottled in bottles packed in... such purposes are considered to be exported. Export status is not acquired until application on Form...

  19. E-business and small Ghanaian exporters

    DEFF Research Database (Denmark)

    Hinson, Robert; Sørensen, Olav Jull

    2006-01-01

    The arfticle aims to investigate the relationship between export intensity and e-business adoption in Ghana. No clear relationship is found among exporters of non-traditional items.......The arfticle aims to investigate the relationship between export intensity and e-business adoption in Ghana. No clear relationship is found among exporters of non-traditional items....

  20. 31 CFR 592.304 - Exporting authority.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Exporting authority. 592.304 Section... § 592.304 Exporting authority. (a) The term exporting authority means one or more entities designated by a Participant from whose territory a shipment of rough diamonds is being exported as having...

  1. 19 CFR 18.26 - Indirect exportation.

    Science.gov (United States)

    2010-04-01

    ... merchandise to be exported and provide such evidence of exportation as required by the port director under... 19 Customs Duties 1 2010-04-01 2010-04-01 false Indirect exportation. 18.26 Section 18.26 Customs... TRANSPORTATION IN BOND AND MERCHANDISE IN TRANSIT Exportation from Customs Custody of Merchandise Unentered...

  2. 19 CFR 18.42 - Direct exportation.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Direct exportation. 18.42 Section 18.42 Customs... TRANSPORTATION IN BOND AND MERCHANDISE IN TRANSIT Merchandise Not Otherwise Subject to Customs Control Exported Under Cover of A Tir Carnet § 18.42 Direct exportation. At the port of exportation, the container...

  3. 19 CFR 18.25 - Direct exportation.

    Science.gov (United States)

    2010-04-01

    ... to be exported and provide such evidence of exportation as required by the port director under § 113... 19 Customs Duties 1 2010-04-01 2010-04-01 false Direct exportation. 18.25 Section 18.25 Customs... TRANSPORTATION IN BOND AND MERCHANDISE IN TRANSIT Exportation from Customs Custody of Merchandise Unentered...

  4. 14 CFR 1274.942 - Export licenses.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Export licenses. 1274.942 Section 1274.942... FIRMS Other Provisions and Special Conditions § 1274.942 Export licenses. Export Licenses July 2002 (a) The Recipient shall comply with all U.S. export control laws and regulations, including...

  5. 77 FR 40493 - Export Administration Regulations

    Science.gov (United States)

    2012-07-10

    ... Bureau of Industry and Security 15 CFR Parts 740, 742, 748, 750, 752, and 760 Export Administration... heading of paragraph (d) to read ``Shippers Export Declaration or Automated Export System Record''. 0 2...): Once a mass market classification request is accepted in SNAP-R, you may export and reexport...

  6. 77 FR 16768 - Export Sales Reporting Requirements

    Science.gov (United States)

    2012-03-22

    ... Office of the Secretary 7 CFR Part 20 RIN 0551-AA70 Export Sales Reporting Requirements AGENCY: Office of... frozen box/primal cuts) and distillers dried grain (DDG) to the Export Sales Reporting Requirements, is..., Branch Chief, Export Sales Reporting Branch, Import Policies and Export Reporting Division, Office...

  7. 77 FR 72322 - Order Denying Export Privileges

    Science.gov (United States)

    2012-12-05

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Kue Sang Chun... convicted of violating Section 38 of the Arms Export Control Act (22 U.S.C. 2778 (2000)) (``AECA''). Specifically, Chun was convicted of knowingly exporting and causing the export from the United States to...

  8. 78 FR 60248 - Order Denying Export Privileges

    Science.gov (United States)

    2013-10-01

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Volha Dubouskaya... States, that is, to willfully export from the United States to Belarus export-controlled items, including... of $100.00. Section 766.25 of the Export Administration Regulations (``EAR'' or ``Regulations'')...

  9. 78 FR 58995 - Order Denying Export Privileges

    Science.gov (United States)

    2013-09-25

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Iman Kazerani, 153... was convicted of knowingly and willfully exporting and causing the exportation of laptop computers..., a $10,000 criminal fine and an assessment of $100. Section 766.25 of the Export...

  10. Rising Threshold Shows Export Ambition

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Beginning from March 1 of this year,China only allows authorized manufacturers to engage in automobile exports in an effort to raise auto quality.The licensing system,jointly introduced by Ministry of Commerce,National Development and Reform Commission,General Administration of Customs,State Quality Inspection Administration and Certification and Accreditation Administration of China,aims to ensure that only large and credible auto manufacturers take part in auto exports.

  11. BRAZILIAN EXPORTS OF MANUFACTURED WOOD

    Directory of Open Access Journals (Sweden)

    Rafael de Azevedo Calderon

    2010-08-01

    Full Text Available The present work deals with the Brazilian exports of sawnwood of non-coniferous, veneer sheets and plywood, from 1961 to 2002. The data regarding the three studied products, sawnwood of non-coniferous, veneer sheets and plywood, were joined through the method of Fisher so that an econometric evaluation of the market of the three products could be carried out. Supply and demand models of the Brazilian exports were specified. The results were satisfactory and they match with the literature. The supply of exports presented a positive answer in relation to the exporter's remuneration, to the production, to the use of the installed capacity (cycles of domestic economical activity and to the tendency, and negative in relation to the internal demand. The demand for the Brazilian exports was influenced positively by the world income, participation index and tendency, and negatively for the relative price. The low elasticity-price of the found demand can have implications in the conservation of the Brazilian forest resources because the exporters can increase the prices, reduce the amounts and still increase the incomes.

  12. 76 FR 11756 - Action Affecting Export Privileges; Ali Amirnazmi; Order Denying Export Privileges

    Science.gov (United States)

    2011-03-03

    ... Bureau of Industry and Security Action Affecting Export Privileges; Ali Amirnazmi; Order Denying Export... 766.25 of the Export Administration Regulations (``EAR'' or ``Regulations'') \\1\\ provides, in... the Office of Export Enforcement, may deny the export privileges of any person who has been convicted...

  13. 78 FR 61743 - Revisions to the Export Administration Regulations: Initial Implementation of Export Control...

    Science.gov (United States)

    2013-10-03

    ..., et al. Revisions to the Export Administration Regulations: Initial Implementation of Export Control...-AF65 Revisions to the Export Administration Regulations: Initial Implementation of Export Control... Register of April 16, 2013. As part of the Export Control Reform (ECR) Initiative, the Bureau of...

  14. 78 FR 29700 - President's Export Council; Subcommittee on Export Administration; Notice of Open Meeting

    Science.gov (United States)

    2013-05-21

    ... Bureau of Industry and Security President's Export Council; Subcommittee on Export Administration; Notice of Open Meeting The President's Export Council Subcommittee on Export Administration (PECSEA) will...). The PECSEA provides advice on matters pertinent to those portions of the Export Administration Act,...

  15. 76 FR 10004 - President's Export Council; Subcommittee on Export Administration; Notice of Open Meeting

    Science.gov (United States)

    2011-02-23

    ... Bureau of Industry and Security President's Export Council; Subcommittee on Export Administration; Notice of Open Meeting The President's Export Council Subcommittee on Export Administration (PECSEA) will... provides advice on matters pertinent to those portions of the Export Administration Act, as amended,...

  16. 77 FR 8807 - President's Export Council, Subcommittee on Export Administration; Notice of Open Meeting

    Science.gov (United States)

    2012-02-15

    ... Bureau of Industry and Security President's Export Council, Subcommittee on Export Administration; Notice of Open Meeting The President's Export Council Subcommittee on Export Administration (PECSEA) will... pertinent to those portions of the Export Administration Act, as amended, that deal with United...

  17. 19 CFR 122.78 - Entry or withdrawal for exportation or for transportation and exportation.

    Science.gov (United States)

    2010-04-01

    ... for exportation or for transportation and exportation. If a shipment is exported under an entry or... 19 Customs Duties 1 2010-04-01 2010-04-01 false Entry or withdrawal for exportation or for transportation and exportation. 122.78 Section 122.78 Customs Duties U.S. CUSTOMS AND BORDER...

  18. 15 CFR 732.5 - Steps regarding Shipper's Export Declaration or Automated Export System record, Destination...

    Science.gov (United States)

    2010-01-01

    ... Declaration or Automated Export System record, Destination Control Statements, and recordkeeping. 732.5... THE EAR § 732.5 Steps regarding Shipper's Export Declaration or Automated Export System record... Automated Export System (AES) record. Exporters or agents authorized to complete the Shipper's...

  19. 15 CFR 758.1 - The Shipper's Export Declaration (SED) or Automated Export System (AES) record.

    Science.gov (United States)

    2010-01-01

    ...) or Automated Export System (AES) record. 758.1 Section 758.1 Commerce and Foreign Trade Regulations... (SED) or Automated Export System (AES) record. (a) The Shipper's Export Declaration (SED) or Automated Export System (AES) record. The SED (Form 7525-V, Form 7525-V-Alt, or Automated Export System record)...

  20. Continuity and export performance in Peruvian companies

    Directory of Open Access Journals (Sweden)

    Oscar Malca Guaylupo

    2016-01-01

    Full Text Available This paper studies the relationship between continuity of business in international markets and their export performance. For this, the paper focuses on the Peruvian export companies during the period 2000-2008, stage where Peruvian exports had continued growth. the results achieved in international markets are analyzed and through probabilistic logit model establishes the relationship between continuity in these markets and the export performance measured in export sales.

  1. China will Reduce Aluminium Export in 2005

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    <正>Starting from January 1, 2005, China eliminated the 8 per cent export tax rebate for aluminium, and further more, the exporters will have to pay 5 per cent export tax. This is beyond the expectations of the producers, for most of them thought only the 8 per cent export tax rebate would be eliminated and it was still too early to add the export tax.

  2. Do African Manufacturing Firms Learn from Exporting?

    OpenAIRE

    Paul Collier; Marcel Fafchamps; Francis Teal; Stefan Dercon

    2002-01-01

    In this paper, we use firm-level panel data for the manufacturing sector in four African countries to estimate the effect of exporting on efficiency. Estimating simultaneously a production function and an export regression that control for unobserved firm effects, we find both significant efficiency gains from exporting, supporting the learning-byexporting hypothesis, and evidence for self-selection of more efficient firms into exporting. The evidence of learning-by-exporting suggests that Af...

  3. Stable assembly of HIV-1 export complexes occurs cotranscriptionally

    DEFF Research Database (Denmark)

    Nawroth, Isabel; Mueller, Florian; Basyuk, Eugenia

    2014-01-01

    The HIV-1 Rev protein mediates export of unspliced and singly spliced viral transcripts by binding to the Rev response element (RRE) and recruiting the cellular export factor CRM1. Here, we investigated the recruitment of Rev to the transcription sites of HIV-1 reporters that splice either post......- or cotranscriptionally. In both cases, we observed that Rev localized to the transcription sites of the reporters and recruited CRM1. Rev and CRM1 remained at the reporter transcription sites when cells were treated with the splicing inhibitor Spliceostatin A (SSA), showing that the proteins associate with RNA prior...... to or during early spliceosome assembly. Fluorescence recovery after photobleaching (FRAP) revealed that Rev and CRM1 have similar kinetics as the HIV-1 RNA, indicating that Rev, CRM1, and RRE-containing RNAs are released from the site of transcription in one single export complex. These results suggest...

  4. Plasmodium falciparum malaria associated with ABO blood ...

    African Journals Online (AJOL)

    Plasmodium falciparum malaria associated with ABO blood phenotypes and ... out to investigate the relationship between blood group types and P. falciparum ... of long lasting treated (LLT) mosquito bed nets and the prevalence of infection.

  5. Plasmodium Helical Interspersed Subtelomeric (PHIST) Proteins, at the Center of Host Cell Remodeling

    Science.gov (United States)

    Warncke, Jan D.; Vakonakis, Ioannis

    2016-01-01

    SUMMARY During the asexual cycle, Plasmodium falciparum extensively remodels the human erythrocyte to make it a suitable host cell. A large number of exported proteins facilitate this remodeling process, which causes erythrocytes to become more rigid, cytoadherent, and permeable for nutrients and metabolic products. Among the exported proteins, a family of 89 proteins, called the Plasmodium helical interspersed subtelomeric (PHIST) protein family, has been identified. While also found in other Plasmodium species, the PHIST family is greatly expanded in P. falciparum. Although a decade has passed since their first description, to date, most PHIST proteins remain uncharacterized and are of unknown function and localization within the host cell, and there are few data on their interactions with other host or parasite proteins. However, over the past few years, PHIST proteins have been mentioned in the literature at an increasing rate owing to their presence at various localizations within the infected erythrocyte. Expression of PHIST proteins has been implicated in molecular and cellular processes such as the surface display of PfEMP1, gametocytogenesis, changes in cell rigidity, and also cerebral and pregnancy-associated malaria. Thus, we conclude that PHIST proteins are central to host cell remodeling, but despite their obvious importance in pathology, PHIST proteins seem to be understudied. Here we review current knowledge, shed light on the definition of PHIST proteins, and discuss these proteins with respect to their localization and probable function. We take into consideration interaction studies, microarray analyses, or data from blood samples from naturally infected patients to combine all available information on this protein family. PMID:27582258

  6. Limitations of microscopy to differentiate Plasmodium species in a region co-endemic for Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi

    OpenAIRE

    Barber Bridget E; William Timothy; Grigg Matthew J; Yeo Tsin W; Anstey Nicholas M

    2013-01-01

    Abstract Background In areas co-endemic for multiple Plasmodium species, correct diagnosis is crucial for appropriate treatment and surveillance. Species misidentification by microscopy has been reported in areas co-endemic for vivax and falciparum malaria, and may be more frequent in regions where Plasmodium knowlesi also commonly occurs. Methods This prospective study in Sabah, Malaysia, evaluated the accuracy of routine district and referral hospital-based microscopy, and microscopy perfor...

  7. The Impact of Firm’s Export Competencies on Export Performance

    Directory of Open Access Journals (Sweden)

    Mustafa Kaplan

    2014-12-01

    Full Text Available The purpose of this study is to investigate the impacts of employees’ export experience and knowledge, firms’ export experience, firms’ export market information, firms’ export commitment on marketing planning capabilities and export performance and the relationship between marketing planning capabilities and export performance. To test hypotheses the data were collected from a sample of 153 firms operating in the automotive part industry in Turkey via structured questionnaire. Results reveal that employees’ export experience and knowledge, firms’ export experience, firms’ export market information, firms’ export commitment are found to be positively related with the marketing planning capabilities and the export performance. Beside, marketing planning capability is found to be related positively with export performance. 

  8. Genome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium species

    KAUST Repository

    Ansari, Hifzur Rahman

    2016-07-05

    Malaria in humans is caused by six species of Plasmodium parasites, of which the nuclear genome sequences for the two Plasmodium ovale spp., P. ovale curtisi and P. ovale wallikeri, and Plasmodium malariae have not yet been analyzed. Here we present an analysis of the nuclear genome sequences of these three parasites, and describe gene family expansions therein. Plasmodium ovale curtisi and P. ovale wallikeri are genetically distinct but morphologically indistinguishable and have sympatric ranges through the tropics of Africa, Asia and Oceania. Both P. ovale spp. show expansion of the surfin variant gene family, and an amplification of the Plasmodium interspersed repeat (pir) superfamily which results in an approximately 30% increase in genome size. For comparison, we have also analyzed the draft nuclear genome of P. malariae, a malaria parasite causing mild malaria symptoms with a quartan life cycle, long-term chronic infections, and wide geographic distribution. Plasmodium malariae shows only a moderate level of expansion of pir genes, and unique expansions of a highly diverged transmembrane protein family with over 550 members and the gamete P25/27 gene family. The observed diversity in the P. ovale wallikeri and P. ovale curtisi surface antigens, combined with their phylogenetic separation, supports consideration that the two parasites be given species status.

  9. Telomeric Heterochromatin in Plasmodium falciparum

    Directory of Open Access Journals (Sweden)

    Rosaura Hernandez-Rivas

    2010-01-01

    Full Text Available Until very recently, little was known about the chromatin structure of the telomeres and subtelomeric regions in Plasmodium falciparum. In yeast and Drosophila melanogaster, chromatin structure has long been known to be an important aspect in the regulation and functioning of these regions. Telomeres and subtelomeric regions are enriched in epigenetic marks that are specific to heterochromatin, such as methylation of lysine 9 of histone H3 and lysine 20 of histone H4. In P. falciparum, histone modifications and the presence of both the heterochromatin “writing” (PfSir2, PKMT and “reading” (PfHP1 machinery at telomeric and subtelomeric regions indicate that these regions are likely to have heterochromatic structure that is epigenetically regulated. This structure may be important for telomere functions such as the silencing of the var gene family implicated in the cytoadherence and antigenic variation of these parasites.

  10. Plasmodium vivax Transmission in Africa.

    Directory of Open Access Journals (Sweden)

    Rosalind E Howes

    2015-11-01

    Full Text Available Malaria in sub-Saharan Africa has historically been almost exclusively attributed to Plasmodium falciparum (Pf. Current diagnostic and surveillance systems in much of sub-Saharan Africa are not designed to identify or report non-Pf human malaria infections accurately, resulting in a dearth of routine epidemiological data about their significance. The high prevalence of Duffy negativity provided a rationale for excluding the possibility of Plasmodium vivax (Pv transmission. However, review of varied evidence sources including traveller infections, community prevalence surveys, local clinical case reports, entomological and serological studies contradicts this viewpoint. Here, these data reports are weighted in a unified framework to reflect the strength of evidence of indigenous Pv transmission in terms of diagnostic specificity, size of individual reports and corroboration between evidence sources. Direct evidence was reported from 21 of the 47 malaria-endemic countries studied, while 42 countries were attributed with infections of visiting travellers. Overall, moderate to conclusive evidence of transmission was available from 18 countries, distributed across all parts of the continent. Approximately 86.6 million Duffy positive hosts were at risk of infection in Africa in 2015. Analysis of the mechanisms sustaining Pv transmission across this continent of low frequency of susceptible hosts found that reports of Pv prevalence were consistent with transmission being potentially limited to Duffy positive populations. Finally, reports of apparent Duffy-independent transmission are discussed. While Pv is evidently not a major malaria parasite across most of sub-Saharan Africa, the evidence presented here highlights its widespread low-level endemicity. An increased awareness of Pv as a potential malaria parasite, coupled with policy shifts towards species-specific diagnostics and reporting, will allow a robust assessment of the public health

  11. Measuring the Export Subsidy Equivalents (ESEs) through Price Discrimination Generated by Exporting State Trading Enterprises

    OpenAIRE

    Suzuki, Nobuhiko; Kinoshita, Junko; FUJII, Toshiaki; Kaise, Harry M.

    2005-01-01

    The Doha Round framewoek agreements state that all forms of export sucsides should be eliminated, which includes not only export subsides through food aid and export credits, but also "consumer financed" ones through exporting STEs. Therefore, one needs a theoretical definition and practical measurements of "hidden" export subsides unregulated under the current WTO rules. This paper proposes a basic definition for the "consumer financed" export subsidy equivalent (ESE) created by STEs' price ...

  12. The Effect of Export Tax on Indonesia’s Cocoa Export Competitiveness

    OpenAIRE

    2013-01-01

    The government of Indonesia implemented an export tax policy on cocoa beans since April 2010 in order to develop cocoa processing industry. The objective of this article is to analyze the effect of export tax on Indonesia’s cocoa export competitiveness. The results indicate that with the implementation of export tax, cocoa export product composition shift from cocoa beans to processed cocoa products. On the other hand, Indonesia’s cocoa export growth is lower than the growth of cocoa world de...

  13. The Impact of Firm’s Export Competencies on Export Performance

    OpenAIRE

    Mustafa Kaplan; Selim Said Eren

    2014-01-01

    The purpose of this study is to investigate the impacts of employees’ export experience and knowledge, firms’ export experience, firms’ export market information, firms’ export commitment on marketing planning capabilities and export performance and the relationship between marketing planning capabilities and export performance. To test hypotheses the data were collected from a sample of 153 firms operating in the automotive part industry in Turkey via structured questionnaire. Results reveal...

  14. Managerial and learning skills in exporting SMEs

    Directory of Open Access Journals (Sweden)

    RUBÉN FERNÁNDEZ ORTIZ

    2005-12-01

    Full Text Available The relevance of the perception of exports in the field of business management can have a key impact on the exporting behavior of SMEs. In particular, it can determine the decision to implement an export policy, as well as the policies applied to consolidate exports. This paper covers two main aspects. First, the extent to which managerial perceptions of exports affect the decision to export, and second, for these SMEs which are already exporters, we study the managerial perceptions that can help to consolidate their commitment to exports. To this aim, some scales based on structural equations to measure the perception of the advantages and disadvantages of exporting are developed and validated. Both analyses are carried out considering whether the SMEs involved are family businesses or not, so that the results obtained can also explain the potential impact of this fact.

  15. Export Competitiveness of Textile Commodities: A Panel Data Approach

    OpenAIRE

    Arora, Tarun

    2015-01-01

    The Paper assesses the export competitiveness of top fifteen textile products (different for each export destination) at 6 digit level of HS classification exported by India to top seven textile export destinations by using both price and income export elasticities. The export elasticities are estimated using dynamic panel data approach for each country separately. Commodity specific elasticities are further estimated to forecast the exports of commodities exported to respective export destin...

  16. Determinants of Short-Term Export Performance in Pakistan

    OpenAIRE

    Subhani, Muhammad Imtiaz; Osman, Ms. Amber; Habib, Sukaina

    2010-01-01

    This research investigates the interdependency between independent (Increase of pricing strategy adaptation, Increase of export intensity, Firm's commitment to exporting, Export market development, Export market competition, Past Pricing Strategy Adaptation, Past Export Performance Satisfaction, Past Export Intensity, Export market distance) and dependent variables (i.e. Expected Short-Term Export Performance improvement) of export performance. The framework is tested via a survey through que...

  17. Export Readiness Assessment of Ten Iranian Pharmaceutical Companies and Comparison with their Export Performance

    Directory of Open Access Journals (Sweden)

    Mehdi Mohammadzadeh, Mohammad Poloee, Tayebeh Ghari

    2016-09-01

    Full Text Available Background: In the area of exporting, in developing countries, including Iran, the concept of export readiness is unknown to many decision makers and field of activity of Iranian pharmaceutical companies have been limited to the domestic market. Therefore, the main objective of this study is to compare the export performance of ten Iranian pharmaceutical companies with their export readiness. Methods: In order to do this, the top ten of Iranian pharmaceutical companies were selected as the sample. The companies' export readiness was measured, and compared with their export volume as well as their export growth (as two factors for determining the export performance in five years, to practically check the model and find the strengths and weaknesses of these Iranian pharmaceutical companies in the export factors. Results: Base on the results of the study, the export readiness of these companies does not have significant correlation with companies' export volume in the current circumstances, but it can predict the export growth in the firm's export rate with 95% certainty. Conclusion: The most important thing is that according to the data collected in our study, most of these ten Iranian pharmaceutical companies are not ready to attend in exporting and international markets and only two companies were ready to export. It seems that making improvement in some variables like obtaining international standards, marketing and exporting education, having a transparent and documented plan and having the responsible person for export could increase export readiness of pharmaceutical companies.

  18. Quality, Export and Economic Growth

    DEFF Research Database (Denmark)

    Madsen, Erik Strøjer; Pedersen, Kurt

    1998-01-01

    in an international context. The paper, therefore, addresses the complicated interactions between economic growth, export performance and quality. The contribution of the paper, compared to other growth accounting research, is the inclusion of quality data, quality being a significant mirror of technological...... development. The countries covered by the research represent a wide variation in terms of economic development, from poor LDC's to the most developed industrial nations. The empirical results reveal a probable strong relationship between quality/price and export growth as well as economic growth. This new...

  19. Creative destruction and export patterns

    DEFF Research Database (Denmark)

    Hansen, Jørgen Drud; Kvedaras, Virmantas; Nielsen, Jørgen Ulff-Møller

    2014-01-01

    varieties obsolete. For a given technology (variety) production costs decrease after an infant period due to learning. While all firms are assumed to be symmetric in a life-cycle perspective, at a given point in time firms of different ages differ in productivity, firm size, product quality, and export...... behavior. The model highlights a process of creative destruction, which allows firms to produce in a finite span of periods determined by the intensity of product and process innovations. The model predicts a wide range of export behavior of the individual firm during its life cycle depending...

  20. The dynamics of natural Plasmodium falciparum infections.

    Directory of Open Access Journals (Sweden)

    Ingrid Felger

    Full Text Available BACKGROUND: Natural immunity to Plasmodium falciparum has been widely studied, but its effects on parasite dynamics are poorly understood. Acquisition and clearance rates of untreated infections are key elements of the dynamics of malaria, but estimating these parameters is challenging because of frequent super-infection and imperfect detectability of parasites. Consequently, information on effects of host immune status or age on infection dynamics is fragmentary. METHODS: An age-stratified cohort of 347 individuals from Northern Ghana was sampled six times at 2 month intervals. High-throughput capillary electrophoresis was used to genotype the msp-2 locus of all P. falciparum infections detected by PCR. Force of infection (FOI and duration were estimated for each age group using an immigration-death model that allows for imperfect detection of circulating parasites. RESULTS: Allowing for imperfect detection substantially increased estimates of FOI and duration. Effects of naturally acquired immunity on the FOI and duration would be reflected in age dependence in these indices, but in our cohort data FOI tended to increase with age in children. Persistence of individual parasite clones was characteristic of all age-groups. Duration peaked in 5-9 year old children (average duration 319 days, 95% confidence interval 318;320. CONCLUSIONS: The main age-dependence is on parasite densities, with only small age-variations in the FOI and persistence of infections. This supports the hypothesis that acquired immunity controls transmission mainly by limiting blood-stage parasite densities rather than changing rates of acquisition or clearance of infections.

  1. RNA Export through the NPC in Eukaryotes.

    Science.gov (United States)

    Okamura, Masumi; Inose, Haruko; Masuda, Seiji

    2015-03-20

    In eukaryotic cells, RNAs are transcribed in the nucleus and exported to the cytoplasm through the nuclear pore complex. The RNA molecules that are exported from the nucleus into the cytoplasm include messenger RNAs (mRNAs), ribosomal RNAs (rRNAs), transfer RNAs (tRNAs), small nuclear RNAs (snRNAs), micro RNAs (miRNAs), and viral mRNAs. Each RNA is transported by a specific nuclear export receptor. It is believed that most of the mRNAs are exported by Nxf1 (Mex67 in yeast), whereas rRNAs, snRNAs, and a certain subset of mRNAs are exported in a Crm1/Xpo1-dependent manner. tRNAs and miRNAs are exported by Xpot and Xpo5. However, multiple export receptors are involved in the export of some RNAs, such as 60S ribosomal subunit. In addition to these export receptors, some adapter proteins are required to export RNAs. The RNA export system of eukaryotic cells is also used by several types of RNA virus that depend on the machineries of the host cell in the nucleus for replication of their genome, therefore this review describes the RNA export system of two representative viruses. We also discuss the NPC anchoring-dependent mRNA export factors that directly recruit specific genes to the NPC.

  2. Surface-expressed enolases of Plasmodium and other pathogens

    Directory of Open Access Journals (Sweden)

    Anil Kumar Ghosh

    2011-08-01

    Full Text Available Enolase is the eighth enzyme in the glycolytic pathway, a reaction that generates ATP from phosphoenol pyruvate in cytosolic compartments. Enolase is essential, especially for organisms devoid of the Krebs cycle that depend solely on glycolysis for energy. Interestingly, enolase appears to serve a separate function in some organisms, in that it is also exported to the cell surface via a poorly understood mechanism. In these organisms, surface enolase assists in the invasion of their host cells by binding plasminogen, an abundant plasma protease precursor. Binding is mediated by the interaction between a lysine motif of enolase with Kringle domains of plasminogen. The bound plasminogen is then cleaved by specific proteases to generate active plasmin. Plasmin is a potent serine protease that is thought to function in the degradation of the extracellular matrix surrounding the targeted host cell, thereby facilitating pathogen invasion. Recent work revealed that the malaria parasite Plasmodium also expresses surface enolase, and that this feature may be essential for completion of its life cycle. The therapeutic potential of targeting surface enolases of pathogens is discussed.

  3. A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.

    Science.gov (United States)

    Volpon, Laurent; Culjkovic-Kraljacic, Biljana; Sohn, Hye Seon; Blanchet-Cohen, Alexis; Osborne, Michael J; Borden, Katherine L B

    2017-06-01

    The eukaryotic translation initiation factor eIF4E acts in the nuclear export and translation of a subset of mRNAs. Both of these functions contribute to its oncogenic potential. While the biochemical mechanisms that underlie translation are relatively well understood, the molecular basis for eIF4E's role in mRNA export remains largely unexplored. To date, over 3000 transcripts, many encoding oncoproteins, were identified as potential nuclear eIF4E export targets. These target RNAs typically contain a ∼50-nucleotide eIF4E sensitivity element (4ESE) in the 3' UTR and a 7-methylguanosine cap on the 5' end. While eIF4E associates with the cap, an unknown factor recognizes the 4ESE element. We previously identified cofactors that functionally interacted with eIF4E in mammalian cell nuclei including the leucine-rich pentatricopeptide repeat protein LRPPRC and the export receptor CRM1/XPO1. LRPPRC simultaneously interacts with both eIF4E bound to the 5' mRNA cap and the 4ESE element in the 3' UTR. In this way, LRPPRC serves as a specificity factor to recruit 4ESE-containing RNAs within the nucleus. Further, we show that CRM1 directly binds LRPPRC likely acting as the export receptor for the LRPPRC-eIF4E-4ESE RNA complex. We also found that Importin 8, the nuclear importer for cap-free eIF4E, imports RNA-free LRPPRC, potentially providing both coordinated nuclear recycling of the export machinery and an important surveillance mechanism to prevent futile export cycles. Our studies provide the first biochemical framework for the eIF4E-dependent mRNA export pathway. © 2017 Volpon et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  4. Survival strategies of the malarial parasite Plasmodium falciparum

    OpenAIRE

    Ramya, TNC; Surolia, Namita; Surolia, Avadhesha

    2002-01-01

    Plasmodium falciparum, the protozoan parasite causing falciparum malaria, is undoubtedly highly versatile when it comes to survival and defence strategies. Strategies adopted by the asexual blood stages of Plasmodium range from unique pathways of nutrient uptake to immune evasion strategies and multiple drug resistance. Studying the survival strategies of Plasmodium could help us envisage strategies of tackling one of the worst scourges of mankind.

  5. Home Textile Exports Show Recovery Signs

    Institute of Scientific and Technical Information of China (English)

    Yao Lan; Guoyun

    2010-01-01

    @@ In this article we have analysed the export performance of Chinese main home textile products, including bedding products, carpet, curtain and towel based on official export data during the first eight months of 2010.

  6. 2006 RE Export Enterprises List Announced

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ According to "Requirement for RE Export Enterprises and Application Procedure in 2006", the Ministry of Commerce P.R.C announced "2006 Rare Earth Export Enterprises List "on December 30th of 2005. The enterprises are listed below.

  7. Export Intermediation and the Internet

    DEFF Research Database (Denmark)

    Andersen, Poul Houman

    2005-01-01

    It is claimed that the remarkable growth in numbers of connected firms to the Internet marks a radical shift in current organisation of international business channels. For export intermediaries these new possibilities pose a threat to their current market position. However, virtual market presence...

  8. A Strong Backbone For Export

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    China Export & Credit Insurance Corp., founded in 2001, is the country’s only policy-oriented credit insurance company. In line with the state’s diplomatic, foreign trade and industrial policies, it supports the country’s commodity, technology and servic

  9. Nuclear Export of Messenger RNA

    Science.gov (United States)

    Katahira, Jun

    2015-01-01

    Transport of messenger RNA (mRNA) from the nucleus to the cytoplasm is an essential step of eukaryotic gene expression. In the cell nucleus, a precursor mRNA undergoes a series of processing steps, including capping at the 5' ends, splicing and cleavage/polyadenylation at the 3' ends. During this process, the mRNA associates with a wide variety of proteins, forming a messenger ribonucleoprotein (mRNP) particle. Association with factors involved in nuclear export also occurs during transcription and processing, and thus nuclear export is fully integrated into mRNA maturation. The coupling between mRNA maturation and nuclear export is an important mechanism for providing only fully functional and competent mRNA to the cytoplasmic translational machinery, thereby ensuring accuracy and swiftness of gene expression. This review describes the molecular mechanism of nuclear mRNA export mediated by the principal transport factors, including Tap-p15 and the TREX complex. PMID:25836925

  10. On American Cultural Exportation Strategy

    Institute of Scientific and Technical Information of China (English)

    李德俊

    2015-01-01

    American government has been attaching great importance to the role that cultural values plays in international relationships and Culture Exportation has gradually become one of the important parts of American diplomatic strategy.This strategy,which is propelled by a variety of impetuses and conducted by different approaches,is mainly aimed to serve the overall national interests of the United States.

  11. On American Cultural Exportation Strategy

    Institute of Scientific and Technical Information of China (English)

    李德俊

    2015-01-01

    American government has been attaching great importance to the role that cultural values plays in international relationships and Culture Exportation has gradually become one of the important parts of American diplomatic strategy. This strategy,which is propelled by a variety of impetuses and conducted by different approaches,is mainly aimed to serve the overall national interests of the United States.

  12. Helminth Parasites Alter Protection against Plasmodium Infection

    Directory of Open Access Journals (Sweden)

    Víctor H. Salazar-Castañon

    2014-01-01

    Full Text Available More than one-third of the world’s population is infected with one or more helminthic parasites. Helminth infections are prevalent throughout tropical and subtropical regions where malaria pathogens are transmitted. Malaria is the most widespread and deadliest parasitic disease. The severity of the disease is strongly related to parasite density and the host’s immune responses. Furthermore, coinfections between both parasites occur frequently. However, little is known regarding how concomitant infection with helminths and Plasmodium affects the host’s immune response. Helminthic infections are frequently massive, chronic, and strong inductors of a Th2-type response. This implies that infection by such parasites could alter the host’s susceptibility to subsequent infections by Plasmodium. There are a number of reports on the interactions between helminths and Plasmodium; in some, the burden of Plasmodium parasites increased, but others reported a reduction in the parasite. This review focuses on explaining many of these discrepancies regarding helminth-Plasmodium coinfections in terms of the effects that helminths have on the immune system. In particular, it focuses on helminth-induced immunosuppression and the effects of cytokines controlling polarization toward the Th1 or Th2 arms of the immune response.

  13. Helminth Parasites Alter Protection against Plasmodium Infection

    Science.gov (United States)

    Salazar-Castañon, Víctor H.; Legorreta-Herrera, Martha

    2014-01-01

    More than one-third of the world's population is infected with one or more helminthic parasites. Helminth infections are prevalent throughout tropical and subtropical regions where malaria pathogens are transmitted. Malaria is the most widespread and deadliest parasitic disease. The severity of the disease is strongly related to parasite density and the host's immune responses. Furthermore, coinfections between both parasites occur frequently. However, little is known regarding how concomitant infection with helminths and Plasmodium affects the host's immune response. Helminthic infections are frequently massive, chronic, and strong inductors of a Th2-type response. This implies that infection by such parasites could alter the host's susceptibility to subsequent infections by Plasmodium. There are a number of reports on the interactions between helminths and Plasmodium; in some, the burden of Plasmodium parasites increased, but others reported a reduction in the parasite. This review focuses on explaining many of these discrepancies regarding helminth-Plasmodium coinfections in terms of the effects that helminths have on the immune system. In particular, it focuses on helminth-induced immunosuppression and the effects of cytokines controlling polarization toward the Th1 or Th2 arms of the immune response. PMID:25276830

  14. Export channel pricing management for integrated solutions

    OpenAIRE

    Roine, Henna; Sainio, Liisa-Maija; Saarenketo, Sami

    2012-01-01

    This article studies systems integrators' export channel pricing management for integrated solutions. We find support from our empirical case study for the notion that a systems integrator's export channel pricing strategy is multidimensional and dependent on international pricing environment and partner characteristics and that export partnerships have unique implications on a systems integrator's pricing process. The results show that giving up pricing control in export channel context may ...

  15. Globalisation and Ireland s Export Performance

    OpenAIRE

    Ruane, Frances; Siedschlag, Iulia; Murphy, Gavin

    2013-01-01

    PUBLISHED This paper provides empirical evidence on Ireland?s export performance in the context of increased globalisation over the past ten years. Using insights from recent contributions to international trade and economic growth theories, we first examine patterns and changes of revealed comparative advantages for Ireland?s exports of goods and services. We then investigate whether Irish exports have specialised in fast growing industries and markets in world exports over the period. Th...

  16. Export channel pricing management for integrated solutions

    OpenAIRE

    Roine, Henna; Sainio, Liisa-Maija; Saarenketo, Sami

    2012-01-01

    This article studies systems integrators' export channel pricing management for integrated solutions. We find support from our empirical case study for the notion that a systems integrator's export channel pricing strategy is multidimensional and dependent on international pricing environment and partner characteristics and that export partnerships have unique implications on a systems integrator's pricing process. The results show that giving up pricing control in export channel context may ...

  17. An Introduction to Export Assistance in the Internet Age

    DEFF Research Database (Denmark)

    Ramanathan, Somasundaram; Rask, Morten

    2004-01-01

    's (2002) model about web marketing strategies for conceptualizing the Internet related developments associated with export assistance. Finally, we highlight the implications of providing export assistance over the Internet. Those interested in export assistance research and those providing export...

  18. An Introduction to Export Assistance in the Internet Age

    DEFF Research Database (Denmark)

    Ramanathan, Somasundaram; Rask, Morten

    's (2002) model about web marketing strategies for conceptualizing the Internet related developments associated with export assistance. Finally, we highlight the implications of providing export assistance over the Internet. Those interested in export assistance research and those providing export...

  19. 76 FR 52935 - President's Export Council, Subcommittee on Export Administration; Notice of Open Meeting

    Science.gov (United States)

    2011-08-24

    ... Bureau of Industry and Security President's Export Council, Subcommittee on Export Administration; Notice of Open Meeting The President's Export Council Subcommittee on Export Administration (PECSEA) will... Administration Act, as amended, that deal with United States policies of encouraging trade with all...

  20. 75 FR 54857 - President's Export Council, Subcommittee on Export Administration; Notice of Recruitment of...

    Science.gov (United States)

    2010-09-09

    ... Bureau of Industry and Security President's Export Council, Subcommittee on Export Administration; Notice of Recruitment of Private-Sector Members; Date Extension Summary: The President's Export Council Subcommittee on Export Administration (PECSEA) advises the U.S. Government on matters and issues pertinent...

  1. 75 FR 47548 - President's Export Council Subcommittee on Export Administration; Notice of Recruitment of...

    Science.gov (United States)

    2010-08-06

    ... Bureau of Industry and Security President's Export Council Subcommittee on Export Administration; Notice of Recruitment of Private-Sector Members SUMMARY: The President's Export Council Subcommittee on Export Administration (PECSEA) advises the U.S. Government on matters and issues pertinent...

  2. 19 CFR 351.414 - Comparison of normal value with export price (constructed export price).

    Science.gov (United States)

    2010-04-01

    ... Price, Fair Value, and Normal Value § 351.414 Comparison of normal value with export price (constructed... 19 Customs Duties 3 2010-04-01 2010-04-01 false Comparison of normal value with export price... value and, in an investigation, prices used as the basis for export price or constructed export price as...

  3. 15 CFR 752.15 - Export clearance.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Export clearance. 752.15 Section 752.15 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU... COMPREHENSIVE LICENSE § 752.15 Export clearance. (a) Shipper's Export Declaration (SED) or Automated...

  4. 7 CFR 927.12 - Export market.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export market. 927.12 Section 927.12 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Order Regulating Handling Definitions § 927.12 Export market. Export market means any destination...

  5. 22 CFR 120.17 - Export.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Export. 120.17 Section 120.17 Foreign Relations DEPARTMENT OF STATE INTERNATIONAL TRAFFIC IN ARMS REGULATIONS PURPOSE AND DEFINITIONS § 120.17 Export. (a) Export means: (1) Sending or taking a defense article out of the United States in any manner, except...

  6. 7 CFR 915.12 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 915.12 Section 915.12 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Regulating Handling Definitions § 915.12 Export. Export means to ship avocados to any destination which...

  7. 7 CFR 948.17 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 948.17 Section 948.17 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Regulating Handling Definitions § 948.17 Export. Export means the shipment of potatoes to any...

  8. 27 CFR 4.80 - Exports.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Exports. 4.80 Section 4.80... TREASURY LIQUORS LABELING AND ADVERTISING OF WINE General Provisions § 4.80 Exports. The regulations in this part shall not apply to wine exported in bond....

  9. Export growth slowdown from January to April

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    January to April this year, the economic operation of China’s textile industry overall in slowdown trend, the growth rate of output of major products fell significantly, exports and profits were greatly affected, the textile industry is facing great operating pressure. The export side, Japan, EU, U.S. textile and garment export growth has slowed down, the market share

  10. 26 CFR 52.4682-5 - Exports.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 17 2010-04-01 2010-04-01 false Exports. 52.4682-5 Section 52.4682-5 Internal... (CONTINUED) ENVIRONMENTAL TAXES § 52.4682-5 Exports. (a) Overview. This section provides rules relating to the tax imposed under section 4681 on ozone-depleting chemicals (ODCs) that are exported. In...

  11. 7 CFR 947.17 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 947.17 Section 947.17 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Definitions § 947.17 Export. Export means shipment of potatoes beyond the boundaries of continental...

  12. 7 CFR 966.18 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 966.18 Section 966.18 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Handling Definitions § 966.18 Export. Export means shipment of tomatoes beyond the boundaries of the...

  13. 7 CFR 923.15 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 923.15 Section 923.15 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... IN WASHINGTON Order Regulating Handling Definitions § 923.15 Export. Export means to ship...

  14. 27 CFR 7.60 - Exports.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Exports. 7.60 Section 7.60... TREASURY LIQUORS LABELING AND ADVERTISING OF MALT BEVERAGES General Provisions § 7.60 Exports. This part shall not apply to malt beverages exported in bond....

  15. 7 CFR 51.912 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Export. 51.912 Section 51.912 Agriculture Regulations... Standards for Grades of Table Grapes (European or Vinifera Type) 1 Definitions § 51.912 Export. When designated as Export, grapes shall be packed with any of the customary protective materials such as...

  16. 7 CFR 922.15 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 922.15 Section 922.15 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... WASHINGTON Order Regulating Handling Definitions § 922.15 Export. Export means to ship apricots beyond...

  17. 27 CFR 16.31 - Exports.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Exports. 16.31 Section 16... TREASURY LIQUORS ALCOHOLIC BEVERAGE HEALTH WARNING STATEMENT General Provisions § 16.31 Exports. The..., bottled, or labeled for export from the United States, or for delivery to a vessel or aircraft,...

  18. 7 CFR 946.15 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 946.15 Section 946.15 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Regulating Handling Definitions § 946.15 Export. Export means shipment of potatoes beyond the boundaries...

  19. 7 CFR 924.15 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 924.15 Section 924.15 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... WASHINGTON AND IN UMATILLA COUNTY, OREGON Order Regulating Handling Definitions § 924.15 Export. Export...

  20. 7 CFR 959.18 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 959.18 Section 959.18 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... Handling Definitions § 959.18 Export. Export means to ship onions to any destination which is not...

  1. 27 CFR 28.154 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.154..., for Exportation or Transfer to a Foreign-Trade Zone § 28.154 Export marks. In addition to the marks... provisions of part 19 of this chapter, the proprietor shall mark the word “Export” on the Government side of...

  2. 78 FR 35195 - Acquisition Regulations: Export Control

    Science.gov (United States)

    2013-06-12

    ... Parts 925, 952, and 970 RIN 1991-AB99 Acquisition Regulations: Export Control AGENCY: Department of... amend the Department of Energy Acquisition Regulation (DEAR) to add export control requirements... ``DEAR: Export Control and RIN 1991-AB99,'' by any of the following methods: Federal eRulemaking Portal...

  3. 27 CFR 28.193 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.193... Drawback Filing of Notice and Removal § 28.193 Export marks. In addition to the marks and brands required... chapter, the exporter shall mark the word “Export” on the Government side of each case or Government head...

  4. 27 CFR 28.223 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.223... Export marks. In addition to the marks and brands required to be placed on kegs, barrels, cases, crates... “Export” on each container or case before removal for export, for use on vessels or aircraft, or for...

  5. 78 FR 45168 - Acquisition Regulations: Export Control

    Science.gov (United States)

    2013-07-26

    ... Parts 925, 952 and 970 RIN 1991-AB99 Acquisition Regulations: Export Control AGENCY: Department of... Department of Energy Acquisition Regulation (DEAR) to add export control requirements applicable to the... business August 23, 2013. ADDRESSES: You may submit comments, identified by ``DEAR: Export Control and RIN...

  6. 19 CFR 12.4 - Exportation.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Exportation. 12.4 Section 12.4 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY SPECIAL CLASSES... Caustic Or Corrosive Substances § 12.4 Exportation. The exportation of merchandise, the subject of §...

  7. 19 CFR 18.43 - Indirect exportation.

    Science.gov (United States)

    2010-04-01

    .... port to another for actual exportation at the second port, any export declarations required to be... 19 Customs Duties 1 2010-04-01 2010-04-01 false Indirect exportation. 18.43 Section 18.43 Customs... TRANSPORTATION IN BOND AND MERCHANDISE IN TRANSIT Merchandise Not Otherwise Subject to Customs Control...

  8. 78 FR 61953 - Order Denying Export Privileges

    Science.gov (United States)

    2013-10-08

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Timothy Gormley, Inmate... engaging in transactions relating to exporting amplifiers to China and India without obtaining the required... assessment and a $1,000 criminal fine. Section 766.25 of the Export Administration Regulations (``EAR''...

  9. 78 FR 37520 - Order Denying Export Privileges

    Science.gov (United States)

    2013-06-21

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Placido Molina, Jr... convicted of violating Section 38 of the Arms Export Control Act (22 U.S.C. 2778 (2006 & Supp. IV 2010)) (``AECA''). Specifically, Molina was convicted of knowingly and willfully attempting to export and...

  10. 78 FR 60250 - Order Denying Export Privileges

    Science.gov (United States)

    2013-10-01

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Vikramaditya Singh, a.k... attempting to cause the export of digital microwave radios to Iran without the required authorization from... probation, six months of home confinement and a $100,000 fine. Section 766.25 of the Export...

  11. 78 FR 37518 - Order Denying Export Privileges

    Science.gov (United States)

    2013-06-21

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Lee Roy Perez, Inmate... convicted of violating Section 38 of the Arms Export Control Act (22 U.S.C. 2778 (2006 & Supp. IV 2010)) (``AECA''). ] Specifically, Perez was convicted of knowingly and willfully exporting and causing to...

  12. 78 FR 60249 - Order Denying Export Privileges

    Science.gov (United States)

    2013-10-01

    ... Bureau of Industry and Security Order Denying Export Privileges In the Matter of: Andrew Silcox, Inmate... of violating Section 38 of the Arms Export Control Act (22 U.S.C. 2778 (2006 & Supp. IV 2010)) (``AECA''). Specifically, Silcox was convicted of knowingly and willfully exporting from the United...

  13. Accurate identification of the six human Plasmodium spp. causing imported malaria, including Plasmodium ovale wallikeri and Plasmodium knowlesi.

    Science.gov (United States)

    Calderaro, Adriana; Piccolo, Giovanna; Gorrini, Chiara; Rossi, Sabina; Montecchini, Sara; Dell'Anna, Maria Loretana; De Conto, Flora; Medici, Maria Cristina; Chezzi, Carlo; Arcangeletti, Maria Cristina

    2013-09-13

    Accurate identification of Plasmodium infections in non-endemic countries is of critical importance with regard to the administration of a targeted therapy having a positive impact on patient health and management and allowing the prevention of the risk of re-introduction of endemic malaria in such countries. Malaria is no longer endemic in Italy where it is the most commonly imported disease, with one of the highest rates of imported malaria among European non-endemic countries including France, the UK and Germany, and with a prevalence of 24.3% at the University Hospital of Parma. Molecular methods showed high sensitivity and specificity and changed the epidemiology of imported malaria in several non-endemic countries, highlighted a higher prevalence of Plasmodium ovale, Plasmodium vivax and Plasmodium malariae underestimated by microscopy and, not least, brought to light both the existence of two species of P. ovale (Plasmodium ovale curtisi and Plasmodium ovale wallikeri) and the infection in humans by Plasmodium knowlesi, otherwise not detectable by microscopy. In this retrospective study an evaluation of two real-time PCR assays able to identify P. ovale wallikeri, distinguishing it from P. ovale curtisi, and to detect P. knowlesi, respectively, was performed applying them on a subset of 398 blood samples belonging to patients with the clinical suspicion of malaria. These assays revealed an excellent analytical sensitivity and no cross-reactivity versus other Plasmodium spp. infecting humans, suggesting their usefulness for an accurate and complete diagnosis of imported malaria. Among the 128 patients with malaria, eight P. ovale curtisi and four P. ovale wallikeri infections were detected, while no cases of P. knowlesi infection were observed. Real-time PCR assays specific for P. ovale wallikeri and P. knowlesi were included in the panel currently used in the University Hospital of Parma for the diagnosis of imported malaria, accomplishing the goal of

  14. Occurrence of Plasmodium in Anatidae

    Science.gov (United States)

    Herman, C.M.; Kocan, R.M.

    1970-01-01

    Until a little over a decade ago reports of Plasrnodium in geese, ducks, and swans were the result of examination of single blood smears from wild birds. One would gather from the earlier studies that Anatidae are infrequently infected. During the past decade we have conducted studies on prevalence of Plasmodium by an isodiagnosis technique, inoculating blood from wild birds into captive young geese, ducks, and other species of birds and determining the status of infection in the donors by examination of repetitive blood smears from the recipients. Examination by this technique of a series of adult Canada geese from the Seney National Wildlife Refuge in northern Michigan uncovered a prevalence of 60% during five successive years. Domestic geese were the primary recipients but we found that several other species of geese, ducks, and gulls were also susceptible. Similar studies on Canada geese from other areas (Maryland, New Jersey, New York, and southern Michigan) uncovered infection rates from zero to 27%. Following isolation of Plasmodlum in a single canvasback duck (Aythya valisineria) in southern Michigan by inoculation into a domestic duck, a series of 88 canvasbacks from Chesapeake Bay in Maryland this winter uncovered an infection rate of 27%. The most common parasite observed in both the geese and was as P. circumflexum.

  15. Plasmodium knowlesi Skeleton-Binding Protein 1 Localizes to the ‘Sinton and Mulligan’ Stipplings in the Cytoplasm of Monkey and Human Erythrocytes

    Science.gov (United States)

    Lucky, Amuza Byaruhanga; Sakaguchi, Miako; Katakai, Yuko; Kawai, Satoru; Yahata, Kazuhide; Templeton, Thomas J.

    2016-01-01

    The malaria parasite, Plasmodium, exports protein products to the infected erythrocyte to introduce modifications necessary for the establishment of nutrient acquisition and surface display of host interaction ligands. Erythrocyte remodeling impacts parasite virulence and disease pathology and is well documented for the human malaria parasite Plasmodium falciparum, but has been less described for other Plasmodium species. For P. falciparum, the exported protein skeleton-binding protein 1 (PfSBP1) is involved in the trafficking of erythrocyte surface ligands and localized to membranous structures within the infected erythrocyte, termed Maurer's clefts. In this study, we analyzed SBP1 orthologs across the Plasmodium genus by BLAST analysis and conserved gene synteny, which were also recently described by de Niz et al. (2016). To evaluate the localization of an SBP1 ortholog, we utilized the zoonotic malaria parasite, Plasmodium knowlesi. Immunofluorescence assay of transgenic P. knowlesi parasites expressing epitope-tagged recombinant PkSBP1 revealed a punctate staining pattern reminiscent of Maurer's clefts, following infection of either monkey or human erythrocytes. The recombinant PkSBP1-positive puncta co-localized with Giemsa-stained structures, known as ‘Sinton and Mulligan’ stipplings. Immunoelectron microscopy also showed that recombinant PkSBP1 localizes within or on the membranous structures akin to the Maurer's clefts. The recombinant PkSBP1 expressed in P. falciparum-infected erythrocytes co-localized with PfSBP1 at the Maurer's clefts, indicating an analogous trafficking pattern. A member of the P. knowlesi 2TM protein family was also expressed and localized to membranous structures in infected monkey erythrocytes. These results suggest that the trafficking machinery and induced erythrocyte cellular structures of P. knowlesi are similar following infection of both monkey and human erythrocytes, and are conserved with P. falciparum. PMID:27732628

  16. Contributions to improve accounting and financial reporting of exports of goods and services

    OpenAIRE

    Nicolae Paul Virag; Gheorghe Claudiu Feieş; Marian Socoliuc

    2012-01-01

    Foreign trade is a form of foreign economic activity and simultaneously a form of trade in general. Basic forms of trade determines the existence of their methodology to account for flows. At the first level of imports and exports accounting methodology is based on general patterns of purchases and sales records locally, but is supplemented with specific elements of the tax, customs and currency. This paper proposes an approach to exports of goods and services in terms of accounting and taxat...

  17. 19 CFR 122.118 - Exportation from port of arrival.

    Science.gov (United States)

    2010-04-01

    ... copy. (2) Exportation copy. The exportation copy shall be filed by the exporting airline when clearance... aircraft's clearance documents. The exportation and clearance copies shall show the exporting airline's... 19 Customs Duties 1 2010-04-01 2010-04-01 false Exportation from port of arrival. 122.118...

  18. 19 CFR 19.38 - Supervision of exportation.

    Science.gov (United States)

    2010-04-01

    ... the sales ticket procedure for exportation shall be exported only under Customs supervision as... exportation transactions, examination of articles being exported, and audits of the proprietor's records. (b) Supervision of ATF bonded exports. Customs officers may conduct general supervision of exportations...

  19. 50 CFR 14.63 - Export declaration requirements.

    Science.gov (United States)

    2010-10-01

    ... PLANTS IMPORTATION, EXPORTATION, AND TRANSPORTATION OF WILDLIFE Wildlife Declarations § 14.63 Export... Declaration for Importation or Exportation of Fish or Wildlife (Form 3-177) signed by the exporter, or the exporter's agent, shall be filed with the Service prior to the export of any wildlife at the port...

  20. Epidemiology of Plasmodium vivax Malaria in India

    OpenAIRE

    Anvikar, Anupkumar R; Shah, Naman; Dhariwal, Akshay C.; Sonal, Gagan Singh; Pradhan, Madan Mohan; Ghosh, Susanta K; Valecha, Neena

    2016-01-01

    Historically, malaria in India was predominantly caused by Plasmodium vivax, accounting for 53% of the estimated cases. After the spread of drug-resistant Plasmodium falciparum in the 1990s, the prevalence of the two species remained equivalent at the national level for a decade. By 2014, the proportion of P. vivax has decreased to 34% nationally, but with high regional variation. In 2014, P. vivax accounted for around 380,000 malaria cases in India; almost a sixth of all P. vivax cases repor...

  1. Human Capital and Wages in Exporting Firms

    DEFF Research Database (Denmark)

    Munch, Jakob Roland; Skaksen, Jan Rose

    . Using a very rich matched worker-firm longitudinal dataset we find that firms with high export intensities pay higher wages. However, an interaction term between export intensity and skill intensity has a positive impact on wages and it absorbs the direct effect of the export intensity. That is, we find......This paper studies the link between a firms education level, export performance and wages of its workers. We argue that firms may escape intense competition in international markets by using high skilled workers to differentiate their products. This story is consistent with our empirical results...... an export wage premium, but it accrues to workers in firms with high skill intensities...

  2. Phases definition in marketing export process

    Directory of Open Access Journals (Sweden)

    Rajković Dragan

    2004-01-01

    Full Text Available The result of export marketing process depends on its five phases. The first phase-revision of export capacities, inner view on advantages and defects of company concerning export possibilities. The second phase-identification of export strategy market penetration. The forth phase-preparing for the marketing campaign (action. The fifth phase-carrying out the above mentioned activities. This study shows the structure and contents of the mentioned phases. At the end, export marketing analyzed DPV is given as the example.

  3. Engineered resistance to Plasmodium falciparum development in transgenic Anopheles stephensi.

    Directory of Open Access Journals (Sweden)

    Alison T Isaacs

    2011-04-01

    Full Text Available Transposon-mediated transformation was used to produce Anopheles stephensi that express single-chain antibodies (scFvs designed to target the human malaria parasite, Plasmodium falciparum. The scFvs, m1C3, m4B7, and m2A10, are derived from mouse monoclonal antibodies that inhibit either ookinete invasion of the midgut or sporozoite invasion of salivary glands. The scFvs that target the parasite surface, m4B7 and m2A10, were fused to an Anopheles gambiae antimicrobial peptide, Cecropin A. Previously-characterized Anopheles cis-acting DNA regulatory elements were included in the transgenes to coordinate scFv production with parasite development. Gene amplification and immunoblot analyses showed promoter-specific increases in transgene expression in blood-fed females. Transgenic mosquito lines expressing each of the scFv genes had significantly lower infection levels than controls when challenged with P. falciparum.

  4. Study on the establishment of effective nuclear export system

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Byung Koo; So, Dong Sup; Baik, Dae Hyun; Kwack, Eun Ho; Shin, Jang Soo; Yoon, Wan Ki; Park, Wan Soo; Kim, Hyun Tae

    1997-02-01

    To improve Korean nuclear export control system, the modification of the present export license procedure for the nuclear equipment and materials and the classification of control items and their related technologies are required. And it is also necessary to make a database of the original countries who have the right of prior consent. For the efficient export control of LWR items to DPRK, it is desirable to manage the export license scheme of nuclear reactor facility as a total package, and to prepare a control regime for the retransfer of nuclear reactor component such as reactor coolant pump and nuclear fuel whose technologies are not self-reliant. It is especially essential to prepare a systematic procedure for the supply of nuclear equipment and materials to DPRK in order to meet international guidelines of NSG and others through an accord on the nuclear cooperation between Republic of Korea (ROK) and DPRK. The principal elements to be included in the accord are the range of cooperation, the restriction within the peaceful uses, prior consent right in case of retransfer of important nuclear reactor components and of storage, transfer and changes of nuclear fuels, application of safeguards to the supplied Trigger list items, physical protection of nuclear material, requirement of the return of nuclear equipment and materials, and restriction right for the suspension or termination of the agreement. (author). 40 refs., 5 tabs., 8 figs.

  5. Improvement of food exports from Serbia

    Directory of Open Access Journals (Sweden)

    Babić Jasna

    2012-01-01

    Full Text Available This paper deals with the analysis of food exports from Serbia and safety food management system. The food is an important export opportunity for Serbia. Food exports recorded robust growth, higher than the growth of total Serbian exports, with positive balance in foreign trade. In order to exploit identified opportunities, it is necessary to improve domestic production, provide basic quality requirements and develop marketing aspects of export supply. This paper presents the necessary standards of a quality related to the food segment and the most important directions for improving marketing export competitiveness factors of agricultural and food products. The purpose of this paper is to highlight the importance of food safety management system certification in the entire food chain and importance of marketing strategies for export development of these products.

  6. Exporting and Productivity: Learning from Vietnam

    DEFF Research Database (Denmark)

    Newman, Carol; Rand, John; Tarp, Finn;

    2017-01-01

    different policy stance than typical in Africa. This is especially so in promoting export-oriented industry. If learning by exporting is a key driver of progress, then a fundamental reason for Africa's lack of transformation is likely to be the low policy priority given to export promotion in the past....... To enlarge the body of empirical evidence, we use an extensive 2005–2012 firm-level panel data set from Vietnam and separate out productivity effects of exporting due to self-selection. This allows us to conclude that firms actually learn by exporting. We also examine how this learning takes place. Our...... findings suggest that productivity gains are associated with moving to larger scale for foreign-owned firms with little evidence of subsequent learning on export markets. We find strong evidence to suggest that private domestic firms learn and accumulate knowledge from export markets with learning...

  7. Perceived impediments to export involvement among small and medium sized firms : non-exporters perspective

    Directory of Open Access Journals (Sweden)

    Mercy Mpinganjira

    2011-12-01

    Full Text Available Purpose: The main purpose of this paper is to examine perceived impediments to export involvement among non-exporting small and medium sized firms (SME's in Malawi. The study also examines levels of interest in exporting among the firms. Problem investigated: Many countries have programs aimed at promoting export involvement among SME's. Despite this, most SME's continue to ignore exporting as a viable business strategy. Information on perceived impediments to export involvement especially from the non-exporters' perspective is often lacking hence the need for this study. Methodology: Data was collected from 80 owner managers of non-exporting SME's. A structured questionnaire was the main instrument used to collect data. Personal interviews were also held with managers for the purposes of probing their answers to the questions in the questionnaire. Statistical Package for Social Science (SPSS version 18 was used to analyse the quantitative data obtained from use of the structured questionnaire. Qualitative data obtained through personal interviews was analysed used thematic analysis. Findings: The findings of the study showed significant levels of interest in exporting among the firms. The majority of the owner managers indicated willingness to exploit export opportunities that may be readily available to them. The findings however showed that just over half of the respondents had discussed or investigated the possibility of exporting before. On impediments to exporting, the findings showed that managers perceive many factors as important impediments to their firm's involvement in exporting. The top two most important impediments were internal to the firm and related to human resource issues. They included insufficient knowledge about export opportunities and lack of personnel knowledgeable in exporting. Originality and value of the research: A review of literature shows that most export promotion studies tend to focus more on issues relating to

  8. High prevalence of drug-resistance mutations in Plasmodium falciparum and Plasmodium vivax in southern Ethiopia

    OpenAIRE

    Schunk, Mirjam; Kumma, Wondimagegn P.; Barreto Miranda, Isabel; Maha E. Osman; Roewer, Susanne; Alano, Abraham; Loescher, Thomas; Bienzle, Ulrich; Mockenhaupt, Frank P

    2006-01-01

    Background: In Ethiopia, malaria is caused by both Plasmodium falciparum and Plasmodium vivax. Drug resistance of P. falciparum to sulfadoxine-pyrimethamine (SP) and chloroquine (CQ) is frequent and intense in some areas. Methods: In 100 patients with uncomplicated malaria from Dilla, southern Ethiopia, P. falciparum dhfr and dhps mutations as well as P. vivax dhfr polymorphisms associated with resistance to SP and P. falciparum pfcrt and pfmdr1 mutations conferring CQ resistance were assesse...

  9. Export Rebates on Grain Finished

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ According to the State Statistics Bureau, China's consumer price index (CPI) jumped by 6.9 percent year-on-year last November, approaching the high levels seen at the end of 1996, one of the largest areas of increase was the price of grain,which rose by 6.6 percent. There is no doubt the growth in CPI can be mainly attributed to soaring food prices and the diffusion effect of oil price adjustments. Large orders for grain exports have put Chinese grain suppliers under tremendous pressure. In order to solve this problem, the Finance Ministry and State Administration of Taxation together announced that 84 categories of export tax rebates on major types of grain will be eliminated.

  10. Export Rebates on Grain Finished

    Institute of Scientific and Technical Information of China (English)

    Liu; Xinwen

    2008-01-01

      According to the State Statistics Bureau, China's consumer price index (CPI) jumped by 6.9 percent year-on-year last November, approaching the high levels seen at the end of 1996, one of the largest areas of increase was the price of grain,which rose by 6.6 percent. There is no doubt the growth in CPI can be mainly attributed to soaring food prices and the diffusion effect of oil price adjustments. Large orders for grain exports have put Chinese grain suppliers under tremendous pressure. In order to solve this problem, the Finance Ministry and State Administration of Taxation together announced that 84 categories of export tax rebates on major types of grain will be eliminated.……

  11. NAS Panel faults export controls

    Science.gov (United States)

    Katzoff, Judith A.

    A study prepared by a top-level panel says that current export controls on militarily sensitive U.S. technology may be “overcorrecting” previous weaknesses in that system, resulting in “a complex and confusing control system” that makes it more difficult for U.S. businesses to compete in international markets. Moreover, this control system has “an increasingly corrosive effect” on U.S. relations with allies. The panel recommended that the United States concentrate more effort on bringing about uniformity in the export control policies of countries belonging to the Coordinating Committee on Multilateral Export Controls (CoCom), i.e., most of the member nations in NATO (the North Atlantic Treaty Organization) and Japan.The 21-member panel was appointed by the Committee on Science, Engineering, and Public Policy (COSEPUP), a joint unit of the National Academy of Sciences (NAS), the National Academy of Engineering (NAE), and the Institute of Medicine (IOM). The panel, composed of administrators, researchers, and former government officials, was chaired by AGU member Lew Allen, Jr., director of the Jet Propulsion Laboratory (Pasadena, Calif.) and former chief of staff of the U.S. Air Force. Their report was supported by NAS funds, by a number of private organizations (including AGU), by the U.S. Departments of Commerce, Defense, Energy, and State, by the National Science Foundation, and by the National Aeronautics and Space Administration.

  12. Epidemiology of Plasmodium vivax Malaria in India.

    Science.gov (United States)

    Anvikar, Anupkumar R; Shah, Naman; Dhariwal, Akshay C; Sonal, Gagan Singh; Pradhan, Madan Mohan; Ghosh, Susanta K; Valecha, Neena

    2016-12-28

    Historically, malaria in India was predominantly caused by Plasmodium vivax, accounting for 53% of the estimated cases. After the spread of drug-resistant Plasmodium falciparum in the 1990s, the prevalence of the two species remained equivalent at the national level for a decade. By 2014, the proportion of P. vivax has decreased to 34% nationally, but with high regional variation. In 2014, P. vivax accounted for around 380,000 malaria cases in India; almost a sixth of all P. vivax cases reported globally. Plasmodium vivax has remained resistant to control measures, particularly in urban areas. Urban malaria is predominantly caused by P. vivax and is subject to outbreaks, often associated with increased mortality, and triggered by bursts of migration and construction. The epidemiology of P. vivax varies substantially within India, including multiple relapse phenotypes with varying latencies between primary infection and relapse. Moreover, the hypnozoite reservoir maintains transmission potential and enables reestablishment of the parasite in areas in which it was thought eradicated. The burden of malaria in India is complex because of the highly variable malaria eco-epidemiological profiles, transmission factors, and the presence of multiple Plasmodium species and Anopheles vectors. This review of P. vivax malaria in India describes epidemiological trends with particular attention to four states: Gujarat, Karnataka, Haryana, and Odisha.

  13. Plasmodium falciparum Malaria, Southern Algeria, 2007

    OpenAIRE

    Boubidi, Saïd C; Gassen, Ibrahim; Khechache, Yacine; Lamali, Karima; Tchicha, Boualem; Brengues, Cécile; Menegon, Michela; Severini, Carlo; Fontenille, Didier; Harrat, Zoubir

    2010-01-01

    An outbreak of Plasmodium falciparum malaria occurred in Tinzaouatine in southern Algeria in 2007. The likely vector, Anopheles gambiae mosquitoes, had not been detected in Algeria. Genes for resistance to chloroquine were detected in the parasite. The outbreak shows the potential for an increase in malaria vectors in Algeria.

  14. Congenital Plasmodium falciparum Malaria in Washington, DC.

    Science.gov (United States)

    Del Castillo, Melissa; Szymanski, Ann Marie; Slovin, Ariella; Wong, Edward C C; DeBiasi, Roberta L

    2017-01-11

    Congenital malaria is rare in the United States, but is an important diagnosis to consider when evaluating febrile infants. Herein, we describe a case of congenital Plasmodium falciparum malaria in a 2-week-old infant born in the United States to a mother who had emigrated from Nigeria 3 months before delivery. © The American Society of Tropical Medicine and Hygiene.

  15. Plasmodium falciparum Malaria, Southern Algeria, 2007

    Science.gov (United States)

    Gassen, Ibrahim; Khechache, Yacine; Lamali, Karima; Tchicha, Boualem; Brengues, Cécile; Menegon, Michela; Severini, Carlo; Fontenille, Didier; Harrat, Zoubir

    2010-01-01

    An outbreak of Plasmodium falciparum malaria occurred in Tinzaouatine in southern Algeria in 2007. The likely vector, Anopheles gambiae mosquitoes, had not been detected in Algeria. Genes for resistance to chloroquine were detected in the parasite. The outbreak shows the potential for an increase in malaria vectors in Algeria. PMID:20113565

  16. Plasmodium falciparum Malaria, Southern Algeria, 2007

    OpenAIRE

    Boubidi, Saïd C; Gassen, Ibrahim; Khechache, Yacine; Lamali, Karima; Tchicha, Boualem; Brengues, Cécile; Menegon, Michela; Severini, Carlo; Fontenille, Didier; Harrat, Zoubir

    2010-01-01

    An outbreak of Plasmodium falciparum malaria occurred in Tinzaouatine in southern Algeria in 2007. The likely vector, Anopheles gambiae mosquitoes, had not been detected in Algeria. Genes for resistance to chloroquine were detected in the parasite. The outbreak shows the potential for an increase in malaria vectors in Algeria.

  17. Plasmodium knowlesi in travellers, update 2014.

    Science.gov (United States)

    Müller, Mattia; Schlagenhauf, Patricia

    2014-05-01

    Since the initial discovery of Plasmodium knowlesi in Malaysia, cases have been reported from several neighbouring countries. Tourism has also resulted in an increasing number of cases diagnosed in Europe, America, and Oceania. In this review we focus on the risk of the travel-associated acquisition of P. knowlesi malaria. A search of the literature in PubMed was carried out to identify articles and literature on the distribution of P. knowlesi infections in Southeast Asia and details of its acquisition and importation by travellers to other continents. The cut-off date for the search was December 1, 2013. Search words used were: "Plasmodium knowlesi", "Plasmodium knowlesi infections", "Plasmodium knowlesi travellers", "Plasmodium knowlesi prevalence", "Plasmodium knowlesi host", "Plasmodium knowlesi vector" "Plasmodium knowlesi RDT", and "Plasmodium knowlesi Malaysia". Traveller numbers to Malaysia were obtained from the Tourism Malaysia website. A total of 103 articles were found. Using a selection of these and others identified from the reference lists of the papers, we based our review on a total of 66 articles. P. knowlesi malaria appears to be the most common malaria species in Malaysian Borneo and is also widely distributed on the Malaysian mainland. Furthermore, locally transmitted cases of P. knowlesi malaria have been reported in Thailand, the Philippines, Vietnam, Singapore, Myanmar, Indonesian Borneo, and Cambodia. Two cases have been reported from non-endemic countries in Asia (Japan and Taiwan) in people with a history of travel to Malaysia and the Philippines. Twelve cases were imported to their home countries by travellers from other continents: two from the USA, two from the Netherlands, two from Germany, and one each from Spain, France, Sweden, Finland, Australia, and New Zealand. In most cases, the infection was associated with a trip to or near forested areas. The symptoms were fever (n=12), headache (n=6), chills (n=6), nausea (n=4), myalgia (n

  18. An automated method for determining the cytoadhesion of Plasmodium falciparum-infected erythrocytes to immobilized cells

    DEFF Research Database (Denmark)

    Hempel, Casper; Boisen, Ida M; Efunshile, Akinwale;

    2015-01-01

    BACKGROUND: Plasmodium falciparum exports antigens to the surface of infected erythrocytes causing cytoadhesion to the host vasculature. This is central in malaria pathogenesis but in vitro studies of cytoadhesion rely mainly on manual counting methods. The current study aimed at developing...... an automated high-throughput method for this purpose utilizing the pseudoperoxidase activity of intra-erythrocytic haemoglobin. METHODS: Chinese hamster ovary (CHO) cells were grown to confluence in chamber slides and microtiter plates. Cytoadhesion of co-cultured P. falciparum, selected for binding to CHO...... using: i) binding of P. falciparum-infected erythrocytes to CHO cells over-expressing chondroitin sulfate A and ii) CHO cells transfected with CD36. Binding of infected erythrocytes including field isolates to primary endothelial cells was also performed. Data was analysed using linear regression...

  19. Export Marketing of Croatian Baby Beef

    Directory of Open Access Journals (Sweden)

    Ante Kolega

    2003-09-01

    Full Text Available Croatia has traditionally been the exporter of livestock and beef. In 1988 Croatia exported a record of 35,7 thousand tons of livestock, worth almost 60 million US $. During the period between 1981 and 1991, the export of beef and processed meat was somewhat smaller, about 12,8 thousand tons, 40 million US $ worth. The most important export destinations were Italy, with almost 90% of all volume and monetary value of export, and Greece. In March 1993 EU has banned the import of livestock and beef from Croatia, due to a scandal with infected cattle. In spite of the subsequent abolition of this ban, Croatian export never really recovered, so today the export of beef amounts to less than a thousand tons. Even though the conditions on the export markets and in the domestic cattle breeding industry have changed, we think that it is possible to achieve the export expansion of Croatian baby beef in the foreign market. This article describes the results of the research conducted on the Italian and Greek market. According to expert opinions and the results of our survey it is evident that, with a certain quality of the product, it would be possible to renew the export of Croatian baby beef to the target markets.

  20. 15 CFR 30.6 - Electronic Export Information data elements.

    Science.gov (United States)

    2010-01-01

    ... kilograms, which includes the weight of the commodity, as well as the weight of normal packaging, such as...) Rail shipments. Report the bill of lading (BL) number for rail shipments. The BL number is the... optional for rail shipments. (iv) Truck shipments. Report the freight or pro bill number for...

  1. Plasmodium in the postgenomic era: new insights into the molecular cell biology of malaria parasites.

    Science.gov (United States)

    Garcia, Celia R S; de Azevedo, Mauro F; Wunderlich, Gerhard; Budu, Alexandre; Young, Jason A; Bannister, Lawrence

    2008-01-01

    In this review, we bring together some of the approaches toward understanding the cellular and molecular biology of Plasmodium species and their interaction with their host red blood cells. Considerable impetus has come from the development of new methods of molecular genetics and bioinformatics, and it is important to evaluate the wealth of these novel data in the context of basic cell biology. We describe how these approaches are gaining valuable insights into the parasite-host cell interaction, including (1) the multistep process of red blood cell invasion by the merozoite; (2) the mechanisms by which the intracellular parasite feeds on the red blood cell and exports parasite proteins to modify its cytoadherent properties; (3) the modulation of the cell cycle by sensing the environmental tryptophan-related molecules; (4) the mechanism used to survive in a low Ca(2+) concentration inside red blood cells; (5) the activation of signal transduction machinery and the regulation of intracellular calcium; (6) transfection technology; and (7) transcriptional regulation and genome-wide mRNA studies in Plasmodium falciparum.

  2. Price and Income Elasticities of Russian Exports

    Directory of Open Access Journals (Sweden)

    Bernardina Algieri

    2004-12-01

    Full Text Available The paper gauges export demand elasticities for Russia using an Error Correction technique within a cointegration framework. An extended version of the Imperfect Substitutes Model has been implemented to estimate the sensitivity of Russian exports without oil components to price and to Russian and world income. Our results suggest a robust and negative long run cointegration relationship between the real effective exchange rate, defined as the weighted average of the rouble’s exchange rates versus a basket of the three currencies with the largest share in the trade turnover adjusted to incorporate inflation rate differences (the ratio of the domestic price indices to the foreign price indices, and Russian exports. An increase in exports by 24% is caused by a real depreciation by 10%. Furthermore, a 10% growth in world income leads to a 33% rise in exports. Finally, exports drop by 14% whenever a 10% increase in domestic income occurs

  3. Baseline study of US industry solar exports

    Energy Technology Data Exchange (ETDEWEB)

    Jacobius, T M; Levi, R S; Bereny, J A

    1980-10-01

    This study is a detailed aggregate profile of US solar export activity in 1979 based on a survey of all segments of the solar industry. It identifies the dollar volume of exports by technology: (1) solar heating and cooling products; (2) wind products; (3) photovoltaics; (4) solar thermal electric; (5) OTEC and biomass; and (6) support products and services. The study offers to government and industry groups, for the first time, comprehensive information with which to formulate export goals and assistance measures based on the current realities of the solar export marketplace. Specific and aggregate recommendations which can lead to identification of realistic solar export opportunities and development of solar export markets are included.

  4. Tax Exportability in Tourism Market

    Directory of Open Access Journals (Sweden)

    Mohammad Mohebi

    2011-01-01

    Full Text Available Problem statement: Tax incidence is a basic topic in public economics as the tourism industry is an increasingly major contributor to government revenue. Generally, government taxation objectives are for the purpose of financing programs that improve people’s lives and economic prosperity, accelerate economic growth and allow for access to sustainable development. In the first view, tax policy decisions by government are based on their effects on the distribution of economic welfare. Therefore, to provide incentives for governments to select a suitable tax policy, exportability of tax is important. Hotel room tax is one of the main parts of tourism tax. Despite the importance of tax for government, it seems that the exportability of hotel room tax is still not well known. Therefore, understanding the counteraction of foreign visitors with respect to its main factors is important for the Malaysian government and tourism management. To achieve these aims, this study examines tax incidence effects on the tourism market. Approach: We use hotel room as representative of tourism market. Quarterly data from 1995-2009 are used and a dynamic model of simultaneous equation is employed. Results: Our results indicate that in the short run supply is elastic and demand is inelastic.But in the long run both demand and supply are elastic to price. Conclusion: Based the results if the government imposes one ringgit (Malaysian currency tax on hotel room price, the tourist contribution is more than 89 and 74% in the short run and long run respectively. Hence, we conclude that the Malaysian tourism market is exportable. Our results also indicate that tax on hotel has no negative social effects in the short run.

  5. Exporting by Migrants and Indigenous Entrepreneurs

    DEFF Research Database (Denmark)

    Ashourizadeh, Shayegheh; Schøtt, Thomas; Pişkinsüt Şengüler, Ece

    2016-01-01

    Migrants may become entrepreneurs in their host countries. They may utilize their dual embeddedness in both the home country and the host country, and also use transnational links to gain a competitive advantage in exporting compared to indigenous entrepreneurs. Migrant entrepreneurs’ advantage may...... around the world was surveyed in the Global Entrepreneurship Monitor, which reports on migration and exporting. Hierarchical linear modeling shows that migrant entrepreneurs export more than indigenous entrepreneurs, especially in the first generation, and especially among educated and male migrants...

  6. Human Capital and Wages in Exporting Firms

    DEFF Research Database (Denmark)

    Munch, Jakob Roland; Skaksen, Jan Rose

    2006-01-01

    This paper studies the link between a firms education level, export performance and wages of its workers. We argue that firms may escape intence competition in international markets by using high skilled workers to differentiate their products. This story is consistent with our empirical results....... an export wage premium, but it accrues to workers in firms with high skill intensities.Keywords: Exports, Wages, Human Capital, Rent Sharing, Matched Worker-Firm DataJEL Classification: J30, F10, I20...

  7. Should Australia Export its Native Birds?

    OpenAIRE

    Kingwell, Ross S.

    1994-01-01

    Commercial export from Australia of native birds, wild or captive bred, is prohibited. This paper firstly describes the current legislation and regulations that restrict the export of native birds and discusses why governments have adopted such a regulatory approach to bird species preservation. Secondly, the paper reviews the debate concerning the export ban, pointing out strengths and weaknesses in arguments and indicating the important role of CITES. Lastly, the paper outlines a new case f...

  8. Effective Border Tax Adjustments for Export Promotion

    OpenAIRE

    Glenn P. Jenkins; Chun-Yan Kuo

    2004-01-01

    In this paper, we address the administration issues associated with the most important border tax adjustments for export expansion. These relate to the refund of input tax credits under the VAT and the relief from customs duties on imported inputs used to produce exports. Such refunds in many developing countries are either not paid in a timely fashion or have been fraudulently overstated in the claims made by exporters. These become impediments that have frequently discouraged foreign invest...

  9. Integrated export development under conditions of globalization

    OpenAIRE

    Jatuliavičienė, Gražina

    2010-01-01

    In the dissertation from the holistic point of view are discussed export development peculiarities in the global area. The main aim of the dissertation is the expansion of the export development concept in consideration to the challenges of globalization. Therefore, peculiarities of internationalization and globalization processes and their connections in the context of export development are discussed; alternation of internationalization models under conditions of globalization is evaluated,...

  10. 75 FR 52505 - Fiscal Year 2011 Veterinary Import/Export Services, Veterinary Diagnostic Services, and Export...

    Science.gov (United States)

    2010-08-26

    ... Animal and Plant Health Inspection Service Fiscal Year 2011 Veterinary Import/Export Services, Veterinary... plasm, organisms, and vectors; for certain veterinary diagnostic services; and for export certification... information on Veterinary Diagnostic program operations, contact Dr. Elizabeth Lautner, Director,...

  11. International Marketing Strategies and the relationship with the export performance and export marketing orientation

    Directory of Open Access Journals (Sweden)

    Marlon Dalmoro

    2010-04-01

    Full Text Available This work aims to identify the relationship between marketing strategies of exporting Taquari Valley firms with the export performance and export market orientation. To achieve the goal sought proposed is the development of theoretical benchmark, made up items strategies for international marketing, export performance and export market orientation. In epistemological level was conducted a survey, applying for a questionnaire to a sample of 25 exporting companies that have industrial activities, chosen in a not probabilistic manner. Finally, it was observed that the key decisions on how to act in various markets in terms of strategies for international marketing - satisfaction with the internal market, international consistency, adaptation and localization level of the strategies - have relationship with the export market orientation and the export performance of studied companies.

  12. Hemoglobinopathies: slicing the Gordian knot of Plasmodium falciparum malaria pathogenesis.

    Science.gov (United States)

    Taylor, Steve M; Cerami, Carla; Fairhurst, Rick M

    2013-01-01

    Plasmodium falciparum malaria kills over 500,000 children every year and has been a scourge of humans for millennia. Owing to the co-evolution of humans and P. falciparum parasites, the human genome is imprinted with polymorphisms that not only confer innate resistance to falciparum malaria, but also cause hemoglobinopathies. These genetic traits--including hemoglobin S (HbS), hemoglobin C (HbC), and α-thalassemia--are the most common monogenic human disorders and can confer remarkable degrees of protection from severe, life-threatening falciparum malaria in African children: the risk is reduced 70% by homozygous HbC and 90% by heterozygous HbS (sickle-cell trait). Importantly, this protection is principally present for severe disease and largely absent for P. falciparum infection, suggesting that these hemoglobinopathies specifically neutralize the parasite's in vivo mechanisms of pathogenesis. These hemoglobin variants thus represent a "natural experiment" to identify the cellular and molecular mechanisms by which P. falciparum produces clinical morbidity, which remain partially obscured due to the complexity of interactions between this parasite and its human host. Multiple lines of evidence support a restriction of parasite growth by various hemoglobinopathies, and recent data suggest this phenomenon may result from host microRNA interference with parasite metabolism. Multiple hemoglobinopathies mitigate the pathogenic potential of parasites by interfering with the export of P. falciparum erythrocyte membrane protein 1 (PfEMP1) to the surface of the host red blood cell. Few studies have investigated their effects upon the activation of the innate and adaptive immune systems, although recent murine studies suggest a role for heme oxygenase-1 in protection. Ultimately, the identification of mechanisms of protection and pathogenesis can inform future therapeutics and preventive measures. Hemoglobinopathies slice the "Gordian knot" of host and parasite

  13. Hemoglobinopathies: Slicing the Gordian Knot of Plasmodium falciparum Malaria Pathogenesis

    Science.gov (United States)

    Taylor, Steve M.; Cerami, Carla; Fairhurst, Rick M.

    2013-01-01

    Plasmodium falciparum malaria kills over 500,000 children every year and has been a scourge of humans for millennia. Owing to the co-evolution of humans and P. falciparum parasites, the human genome is imprinted with polymorphisms that not only confer innate resistance to falciparum malaria, but also cause hemoglobinopathies. These genetic traits—including hemoglobin S (HbS), hemoglobin C (HbC), and α-thalassemia—are the most common monogenic human disorders and can confer remarkable degrees of protection from severe, life-threatening falciparum malaria in African children: the risk is reduced 70% by homozygous HbC and 90% by heterozygous HbS (sickle-cell trait). Importantly, this protection is principally present for severe disease and largely absent for P. falciparum infection, suggesting that these hemoglobinopathies specifically neutralize the parasite's in vivo mechanisms of pathogenesis. These hemoglobin variants thus represent a “natural experiment” to identify the cellular and molecular mechanisms by which P. falciparum produces clinical morbidity, which remain partially obscured due to the complexity of interactions between this parasite and its human host. Multiple lines of evidence support a restriction of parasite growth by various hemoglobinopathies, and recent data suggest this phenomenon may result from host microRNA interference with parasite metabolism. Multiple hemoglobinopathies mitigate the pathogenic potential of parasites by interfering with the export of P. falciparum erythrocyte membrane protein 1 (PfEMP1) to the surface of the host red blood cell. Few studies have investigated their effects upon the activation of the innate and adaptive immune systems, although recent murine studies suggest a role for heme oxygenase-1 in protection. Ultimately, the identification of mechanisms of protection and pathogenesis can inform future therapeutics and preventive measures. Hemoglobinopathies slice the “Gordian knot” of host and parasite

  14. Hemoglobinopathies: slicing the Gordian knot of Plasmodium falciparum malaria pathogenesis.

    Directory of Open Access Journals (Sweden)

    Steve M Taylor

    Full Text Available Plasmodium falciparum malaria kills over 500,000 children every year and has been a scourge of humans for millennia. Owing to the co-evolution of humans and P. falciparum parasites, the human genome is imprinted with polymorphisms that not only confer innate resistance to falciparum malaria, but also cause hemoglobinopathies. These genetic traits--including hemoglobin S (HbS, hemoglobin C (HbC, and α-thalassemia--are the most common monogenic human disorders and can confer remarkable degrees of protection from severe, life-threatening falciparum malaria in African children: the risk is reduced 70% by homozygous HbC and 90% by heterozygous HbS (sickle-cell trait. Importantly, this protection is principally present for severe disease and largely absent for P. falciparum infection, suggesting that these hemoglobinopathies specifically neutralize the parasite's in vivo mechanisms of pathogenesis. These hemoglobin variants thus represent a "natural experiment" to identify the cellular and molecular mechanisms by which P. falciparum produces clinical morbidity, which remain partially obscured due to the complexity of interactions between this parasite and its human host. Multiple lines of evidence support a restriction of parasite growth by various hemoglobinopathies, and recent data suggest this phenomenon may result from host microRNA interference with parasite metabolism. Multiple hemoglobinopathies mitigate the pathogenic potential of parasites by interfering with the export of P. falciparum erythrocyte membrane protein 1 (PfEMP1 to the surface of the host red blood cell. Few studies have investigated their effects upon the activation of the innate and adaptive immune systems, although recent murine studies suggest a role for heme oxygenase-1 in protection. Ultimately, the identification of mechanisms of protection and pathogenesis can inform future therapeutics and preventive measures. Hemoglobinopathies slice the "Gordian knot" of host and

  15. Prioritization and Ranking Problems Exporting Iranian Saffron

    Directory of Open Access Journals (Sweden)

    Reza Askandari

    2013-10-01

    Full Text Available The main objective of this study is to prioritize and rank problems exporting Iranian saffron. Based on a comprehensive review of the literature on issues related to data and information collected from questionnaires, with 816% reliability is used. In this study, the sample of managers and sales and marketing company is exporting Iranian saffron is the sample size of 231 subjects. The results of this study are positive and significant relationship between the dependent variable and the independent variables of export performance of export barriers exist.

  16. ROMANIAN EXPORT COMPETITIVENESS ON THE EUROPEAN MARKET

    Directory of Open Access Journals (Sweden)

    Paul Clipa

    2011-12-01

    Full Text Available Exports of a nation can form a large part of its commercial card on the international market. Global consumer, according to the quality of exports, may associate a certain image about the country of origin. This article aims at explaining the relationship between exports and competitiveness of a nation, the analysis focuses on the nature and intensity of intra-Community exports of Romania. To this end we considered a number of performance indicators that are able to reveal the positioning of trade from Romania to the EU.

  17. Human Capital and Wages in Exporting Firms

    DEFF Research Database (Denmark)

    Munch, Jakob Roland; Skaksen, Jan Rose

    This paper studies the link between a firms education level, export performance and wages of its workers. We argue that firms may escape intense competition in international markets by using high skilled workers to differentiate their products. This story is consistent with our empirical results....... Using a very rich matched worker-firm longitudinal dataset we find that firms with high export intensities pay higher wages. However, an interaction term between export intensity and skill intensity has a positive impact on wages and it absorbs the direct effect of the export intensity. That is, we find...

  18. Markups and Firm-Level Export Status

    DEFF Research Database (Denmark)

    De Loecker, Jan; Warzynski, Frederic

    We derive an estimating equation to estimate markups using the insight of Hall (1986) and the control function approach of Olley and Pakes (1996). We rely on our method to explore the relationship between markups and export behavior using plant-level data. We find significantly higher markups when...... we control for unobserved productivity shocks. Furthermore, we find significant higher markups for exporting firms and present new evidence on markup-export status dynamics. More specifically, we find that firms' markups significantly increase (decrease) after entering (exiting) export markets. We...

  19. Using Click Chemistry to Identify Potential Drug Targets in Plasmodium

    Science.gov (United States)

    2015-04-01

    AWARD NUMBER: W81XWH-13-1-0429 TITLE: Using "Click Chemistry" to Identify Potential Drug Targets in Plasmodium PRINCIPAL INVESTIGATOR: Dr. Purnima...SUBTITLE Sa. CONTRACT NUMBER W81XWH-1 3-1-0429 Using "Click Chemistry" to Identify Potential Drug Targets in Plasmodium 5b. GRANT NUMBER 5c. PROGRAM...Release; Distribution Unlimited 13. SUPPLEMENTARY NOTES 14. ABSTRACT Sporozo ite infection of the liver is the first obl igate step of the Plasmodium

  20. Filarial worms reduce Plasmodium infectivity in mosquitoes.

    Directory of Open Access Journals (Sweden)

    Matthew T Aliota

    Full Text Available BACKGROUND: Co-occurrence of malaria and filarial worm parasites has been reported, but little is known about the interaction between filarial worm and malaria parasites with the same Anopheles vector. Herein, we present data evaluating the interaction between Wuchereria bancrofti and Anopheles punctulatus in Papua New Guinea (PNG. Our field studies in PNG demonstrated that An. punctulatus utilizes the melanization immune response as a natural mechanism of filarial worm resistance against invading W. bancrofti microfilariae. We then conducted laboratory studies utilizing the mosquitoes Armigeres subalbatus and Aedes aegypti and the parasites Brugia malayi, Brugia pahangi, Dirofilaria immitis, and Plasmodium gallinaceum to evaluate the hypothesis that immune activation and/or development by filarial worms negatively impact Plasmodium development in co-infected mosquitoes. Ar. subalbatus used in this study are natural vectors of P. gallinaceum and B. pahangi and they are naturally refractory to B. malayi (melanization-based refractoriness. METHODOLOGY/PRINCIPAL FINDINGS: Mosquitoes were dissected and Plasmodium development was analyzed six days after blood feeding on either P. gallinaceum alone or after taking a bloodmeal containing both P. gallinaceum and B. malayi or a bloodmeal containing both P. gallinaceum and B. pahangi. There was a significant reduction in the prevalence and mean intensity of Plasmodium infections in two species of mosquito that had dual infections as compared to those mosquitoes that were infected with Plasmodium alone, and was independent of whether the mosquito had a melanization immune response to the filarial worm or not. However, there was no reduction in Plasmodium development when filarial worms were present in the bloodmeal (D. immitis but midgut penetration was absent, suggesting that factors associated with penetration of the midgut by filarial worms likely are responsible for the observed reduction in malaria

  1. Export Readiness Assessment of Ten Iranian Pharmaceutical Companies and Comparison with their Export Performance

    OpenAIRE

    Mehdi Mohammadzadeh, Mohammad Poloee, Tayebeh Ghari

    2016-01-01

    Background: In the area of exporting, in developing countries, including Iran, the concept of export readiness is unknown to many decision makers and field of activity of Iranian pharmaceutical companies have been limited to the domestic market. Therefore, the main objective of this study is to compare the export performance of ten Iranian pharmaceutical companies with their export readiness. Methods: In order to do this, the top ten of Iranian pharmaceutical companies were selected as the sa...

  2. Foreign Direct Investment and Electronics Exports: Exploratory Empirical Evidence from Malaysia's Top Five Electronics Exports

    OpenAIRE

    Tuck Cheong Tang; Koi Nyen Wong

    2007-01-01

    The foreign direct investment (FDI) has contributed significantly to Malaysia's electronics exports as well as the growth and development of the electronics industry as a result of the export-oriented industrialization initiatives undertaken since 1970s. The aim of this study is to explore the causation between FDI and electronics exports by using Malaysia''s top five electronics exports by SITC (Standard International Trade Classification) product groups. The findings show a bi-directional c...

  3. 75 FR 44761 - Export Trade Certificate of Review

    Science.gov (United States)

    2010-07-29

    ... opportunities for sales of canned salmon in the Export Markets, selling strategies for the Export Markets, sales... International Trade Administration Export Trade Certificate of Review ACTION: Notice of Application for an Export Trade Certificate of Review From Canned Wild Salmon Export Council, LLC (``CWSEC''). SUMMARY:...

  4. 77 FR 58809 - Export Trade Certificate of Review

    Science.gov (United States)

    2012-09-24

    ... Operation described below in the following Export Trade and Export Markets. Export Trade COL-RICE plans to... Export Trade Activities and Methods of Operation: 1. Purpose: COL-RICE will manage on an open tender..., incluso pulido o glaseado); 1006.4000--broken rice (arroz partido). Export Market The Republic of...

  5. 10 CFR 590.208 - Small volume exports.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Small volume exports. 590.208 Section 590.208 Energy... WITH RESPECT TO THE IMPORT AND EXPORT OF NATURAL GAS Applications for Authorization To Import or Export Natural Gas § 590.208 Small volume exports. Any person may export up to 100,000 cubic feet of natural...

  6. 7 CFR 1488.9 - Evidence of export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Evidence of export. 1488.9 Section 1488.9 Agriculture... Export Sales of Agricultural Commodities From Private Stocks Under CCC Export Credit Sales Program (GSM-5) Documents Required for Financing § 1488.9 Evidence of export. (a) If the commodity is exported by rail...

  7. 21 CFR 1312.22 - Application for export permit.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Application for export permit. 1312.22 Section... EXPORTATION OF CONTROLLED SUBSTANCES Exportation of Controlled Substances § 1312.22 Application for export permit. (a) An application for a permit to export controlled substances shall be made on DEA Form 161...

  8. 77 FR 28853 - Export Trade Certificate of Review

    Science.gov (United States)

    2012-05-16

    ... International Trade Administration Export Trade Certificate of Review ACTION: Notice of issuance of an Export....S. Department of Commerce issued an amended Export Trade Certificate of Review Alaska Longline Cod... number) or email at etca@trade.gov . SUPPLEMENTARY INFORMATION: Title III of the Export Trading Company...

  9. 21 CFR 1312.23 - Issuance of export permit.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Issuance of export permit. 1312.23 Section 1312.23... CONTROLLED SUBSTANCES Exportation of Controlled Substances § 1312.23 Issuance of export permit. (a) The... regulation in § 1312.30 of this part be exported only pursuant to the issuance of an export permit. The...

  10. 78 FR 1837 - Export Trade Certificate of Review

    Science.gov (United States)

    2013-01-09

    ... International Trade Administration Export Trade Certificate of Review ACTION: Notice of issuance of an Export.... Department of Commerce issued an amended Export Trade Certificate of Review to Northwest Fruit Exporters on... Export Trading Company Act of 1982 (15 U.S.C. 4001-21) authorizes the Secretary of Commerce to issue...

  11. 78 FR 53727 - Export Trade Certificate of Review

    Science.gov (United States)

    2013-08-30

    ... International Trade Administration Export Trade Certificate of Review ACTION: Notice of Issuance of an Export Trade Certificate of Review to Northwest Fruit Exporters, Application No. 84-24A12. SUMMARY: The U.S. Department of Commerce issued an amended Export Trade Certificate of Review to Northwest Fruit Exporters...

  12. 22 CFR 125.1 - Exports subject to this part.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Exports subject to this part. 125.1 Section 125... EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.1 Exports subject to this part. (a) The controls of this part apply to the export of technical data and the export of classified defense...

  13. Bifurcation in the chemotactic behavior of Physarum plasmodium

    Science.gov (United States)

    Shirakawa, Tomohiro; Gunji, Yukio-Pegio; Sato, Hiroshi; Tsubakino, Hiroto

    2017-07-01

    The plasmodium of true slime mold Physarum polycephalum is a unicellular and multinuclear giant amoeba. Since the cellular organism has some computational abilities, it is attracting much attention in the field of information science. However, previous studies have mainly focused on the optimization behavior of the plasmodium for a single-modality stimulus, and there are few studies on how the organism adapts to multi-modal stimuli. We stimulated the plasmodium with mixture of attractant and repellent stimuli, and we observed bifurcation in the chemotactic behavior of the plasmodium.

  14. 78 FR 18814 - Amendment to the Export Administration Regulations: List of Items Classified Under Export Control...

    Science.gov (United States)

    2013-03-28

    ... Bureau of Industry and Security 15 CFR Part 774 RIN 0694-AF73 Amendment to the Export Administration Regulations: List of Items Classified Under Export Control Classification 0Y521 Series--Biosensor Systems... specified biosensor systems, ``software'' and ``technology'' under Export Control Classification...

  15. Package power stations for export

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    The cheap and efficient generation of power is an essential requirement for the success and prosperity of any community and is especially important to third world countries. It is therefore logical that the more technologically advanced nations should seek to produce power stations for the developing countries. Power plant can now be designed into a packaged form that may be readily exported and commissioned. This valuable and interesting collection of papers were originally presented at a seminar organised by the Power Industries Division of the Institution of Mechanical Engineers. Topics considered include the developing world market for packaged power stations using indigenous fuels; multi-fuel systems for power generation; packaging, modularisation, and containerisation of equipment for power boilers for export; compact coal-fired industrial plant; rural woodburning power stations; biomass gasification based power generation technology and potential; gas fed reciprocating engine development; packaged heavy duty gas turbines for power generation; and criteria for assessing the appropriateness of package power technologies in developing countries.

  16. Plasmodium Oocysts: Overlooked Targets of Mosquito Immunity.

    Science.gov (United States)

    Smith, Ryan C; Barillas-Mury, Carolina

    2016-12-01

    Although the ability of mosquitoes to limit Plasmodium infection is well documented, many questions remain as to how malaria parasites are recognized and killed by the mosquito host. Recent evidence suggests that anti-Plasmodium immunity is multimodal, with different immune mechanisms regulating ookinete and oocyst survival. However, most experiments determine the number of mature oocysts, without considering that different immune mechanisms may target different developmental stages of the parasite. Complement-like proteins have emerged as important determinants of early immunity targeting the ookinete stage, yet the mechanisms by which the mosquito late-phase immune response limits oocyst survival are less understood. Here, we describe the known components of the mosquito immune system that limit oocyst development, and provide insight into their possible mechanisms of action. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Plasmodium knowlesi malaria in Vietnam: some clarifications

    Directory of Open Access Journals (Sweden)

    Hung Le

    2010-01-01

    Full Text Available Abstract A recently published comment on a report of Plasmodium knowlesi infections in Vietnam states that this may not accurately represent the situation in the study area because the PCR primers used may cross-hybridize with Plasmodium vivax. Nevertheless, P. knowlesi infections have been confirmed by sequencing. In addition, a neighbour-joining tree based on the 18S S-Type SSUrRNA gene shows that the Vietnamese samples clearly cluster with the P. knowlesi isolates identified in Malaysia and are distinct from the corresponding P. vivax sequences. All samples came from asymptomatic individuals who did not consult for fever during the months preceding or following the survey, indicating that asymptomatic P. knowlesi infections occur in this population, although this does not exclude the occurrence of symptomatic cases. Large-scale studies to determine the extent and the epidemiology of P. knowlesi malaria in Vietnam are further needed.

  18. Engineered anopheles immunity to Plasmodium infection.

    Directory of Open Access Journals (Sweden)

    Yuemei Dong

    2011-12-01

    Full Text Available A causative agent of human malaria, Plasmodium falciparum, is transmitted by Anopheles mosquitoes. The malaria parasite is under intensive attack from the mosquito's innate immune system during its sporogonic development. We have used genetic engineering to create immune-enhanced Anopheles stephensi mosquitoes through blood meal-inducible expression of a transgene encoding the IMD pathway-controlled NF-kB Rel2 transcription factor in the midgut and fat-body tissue. Transgenic mosquitoes showed greater resistance to Plasmodium and microbial infection as a result of timely concerted tissue-specific immune attacks involving multiple effectors. The relatively weak impact of this genetic modification on mosquito fitness under laboratory conditions encourages further investigation of this approach for malaria control.

  19. 19 CFR 351.402 - Calculation of export price and constructed export price; reimbursement of antidumping and...

    Science.gov (United States)

    2010-04-01

    ... Export Price, Constructed Export Price, Fair Value, and Normal Value § 351.402 Calculation of export... (date of final determination of sales at less than fair value). (3) Presumption. The Secretary may...) Introduction. In order to establish export price, constructed export price, and normal value, the Secretary...

  20. Exploring the folate pathway in Plasmodium falciparum

    OpenAIRE

    Hyde, John E.

    2005-01-01

    As in centuries past, the main weapon against human malaria infections continues to be intervention with drugs, despite the widespread and increasing frequency of parasite populations that are resistant to one or more of the available compounds. This is a particular problem with the lethal species of parasite, Plasmodium falciparum, which claims some two million lives per year as well as causing enormous social and economic problems. Amongst the antimalarial drugs currently in clinical use, t...

  1. Plasmodium falciparum drug resistance in Angola

    OpenAIRE

    Fançony, Cláudia; Brito, Miguel; Gil, Jose Pedro

    2016-01-01

    Facing chloroquine drug resistance, Angola promptly adopted artemisinin-based combination therapy as the first-line to treat malaria. Currently, the country aims to consolidate malaria control, while preparing for the elimination of the disease, along with others African countries in the region. However, the remarkable capacity of Plasmodium to develop drug resistance represents an alarming threat for those achievements. Herein, the available, but relatively scarce and dispersed, information ...

  2. Do Firms Learn by Exporting or Learn to Export? Evidence from Small and Medium-Sized Enterprises (SMEs) in Swedish Manufacturing

    OpenAIRE

    Hansson, Pär; Eliasson, Kent; Lindvert, Markus

    2009-01-01

    Using a matching approach, we compare the productivity trajectories of future exporters and matched and unmatched non-exporters. Future exporters have higher productivity than do unmatched non-exporters before entry into the export market, which indicates self-selection into exports. More interestingly, we also find a productivity increase among future exporters relative to matched non-exporters 1-2 years before export entry. However, the productivity gap between future exporters and matched ...

  3. Epidemiology of Plasmodium vivax in Indonesia.

    Science.gov (United States)

    Surjadjaja, Claudia; Surya, Asik; Baird, J Kevin

    2016-12-28

    Endemic malaria occurs across much of the vast Indonesian archipelago. All five species of Plasmodium known to naturally infect humans occur here, along with 20 species of Anopheles mosquitoes confirmed as carriers of malaria. Two species of plasmodia cause the overwhelming majority and virtually equal shares of malaria infections in Indonesia: Plasmodium falciparum and Plasmodium vivax The challenge posed by P. vivax is especially steep in Indonesia because chloroquine-resistant strains predominate, along with Chesson-like strains that relapse quickly and multiple times at short intervals in almost all patients. Indonesia's hugely diverse human population carries many variants of glucose-6-phosphate dehydrogenase (G6PD) deficiency, most of them exhibiting severely impaired enzyme activity. Therefore, the patients most likely to benefit from primaquine therapy by preventing aggressive relapse, may also be most likely to suffer harm without G6PD deficiency screening. Indonesia faces the challenge of controlling and eventually eliminating malaria across > 13,500 islands stretching > 5,000 km and an enormous diversity of ecological, ethnographic, and socioeconomic settings, and extensive human migrations. This article describes the occurrence of P. vivax in Indonesia and the obstacles faced in eliminating its transmission. © The American Society of Tropical Medicine and Hygiene.

  4. Role of the ER and Golgi in protein export by Apicomplexa.

    Science.gov (United States)

    Coffey, Michael J; Jennison, Charlie; Tonkin, Christopher J; Boddey, Justin A

    2016-08-01

    Apicomplexan parasites cause diseases of medical and agricultural importance linked to dramatic changes they impart upon infected host cells. Following invasion, the malaria parasite Plasmodium falciparum renovates the host erythrocyte using mechanisms previously believed to be malaria-specific. This involves proteolytic cleavage of effectors in the endoplasmic reticulum that licences proteins for translocation into the host cell. Recently, it was demonstrated that the related parasite Toxoplasma gondii, responsible for disease in immunocompromised individuals and congenital birth defects, has an analogous pathway with some differences, including proteolytic processing in the Golgi. Here we review the similarities and distinctions in export mechanisms between these and other Apicomplexan parasites to reconcile how this group of pathogens modify their host cells to survive and proliferate. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Entrepreneurship, export orientation, and economic growth

    NARCIS (Netherlands)

    S.J.A. Hessels (Jolanda); A.J. van Stel (André)

    2009-01-01

    textabstractIn this paper the relationship between a country’s prevalence of new ventures and its rate of economic growth is investigated, while taking into account new ventures’ export orientation. It is generally acknowledged that new venture creation as well as export activity may both be importa

  6. 77 FR 73627 - 2012 LNG Export Study

    Science.gov (United States)

    2012-12-11

    ...] [FR Doc No: 2012-29894] DEPARTMENT OF ENERGY 2012 LNG Export Study AGENCY: Office of Fossil Energy, Department of Energy. ACTION: Notice of availability of 2012 LNG Export Study and request for comments. Freeport LNG Expansion, L.P. [FE Docket No. 10-161-LNG] and FLNG Liquefaction, LLC. Lake Charles...

  7. Potentials in Asian Export Credit Cooperation

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    "Mekong River Regional Development Project advocated by Asian Development Bank (ADB) has been implemented. Trans-Asia Railway and Trans-Asia Highway are being discussed. It is a good opportunity for Asian Export Credit Agencies (ECAs) to cooperate and financing these large crossboarder projects."On May 11, at the 10th Annual Meeting of Asian Export Credit Agencies,

  8. 27 CFR 24.292 - Exported wine.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Exported wine. 24.292... OF THE TREASURY LIQUORS WINE Removal, Return and Receipt of Wine Removals Without Payment of Tax § 24.292 Exported wine. (a) General. Wine may be removed from a bonded wine premises without payment of tax...

  9. Export Specialisation and Local Economic Growth

    NARCIS (Netherlands)

    Naude, Wim; Bosker, Maarten; Matthee, Marianne

    2010-01-01

    This paper aims to provide empirical evidence on whether export specialization or diversification is better for local economic growth. Using export data from 354 magisterial districts of South Africa for 1996 and 2001 we estimate spatial growth regressions that include measures of the degree of expo

  10. The Export Quotas for Next Year

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    <正>China’s Ministry of Commerce recently announced the 2006 export quotas for some metals commodities. According to the document, China’s export quotas for tungsten and its products will be 15,800 tons. For antimony and its products, the quotas will be

  11. 9 CFR 352.16 - Exports.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Exports. 352.16 Section 352.16 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION... CERTIFICATION EXOTIC ANIMALS AND HORSES; VOLUNTARY INSPECTION Exotic Animals § 352.16 Exports. This shall...

  12. Risk in A Concentrated Export Market

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The export destination of China’s home textile products are considered to be highly concentrated. This is reflected by the statistical data of the past couple of years when, the top export destination of the following products-bedding products, curtain and towel- is United States.

  13. 7 CFR 945.14 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 945.14 Section 945.14 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... COUNTIES IN IDAHO, AND MALHEUR COUNTY, OREGON Order Regulating Handling Definitions § 945.14 Export....

  14. The Decline in China Textile Exports Narrowed

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    This is a crucial moment for China’s textile export industry, which is in the midst of deep economic downturn. In the January-Novem- ber 2009 period, the decline in accumulated textile and apparel exports was being constantly reduced and the tendency of rebound is

  15. 40 CFR 273.56 - Exports.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Exports. 273.56 Section 273.56 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) STANDARDS FOR UNIVERSAL WASTE MANAGEMENT Standards for Universal Waste Transporters § 273.56 Exports. A universal...

  16. China Not the Only Rare Earth Exporter

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ Since China announced it was reducing exports of rare earth,there have been continuous voices in the international community demanding China expand exports or seek alternative resources.The United States has also complained to the WTO that China is hoarding the commodity.

  17. 7 CFR 958.14 - Export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Export. 958.14 Section 958.14 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and... IN IDAHO, AND MALHEUR COUNTY, OREGON Order Regulating Handling Definitions § 958.14 Export....

  18. Home Textile Exports Show Recovery Signs

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    In this article we have analysed the export performance of Chinese main home textile products, including bedding products, carpet, curtain and towel based on official export data during the first eight months of 2010.Let’s first look at the background. The growth in China’s manufacturing

  19. The Silver Export Quota for 2005

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    <正>China’s Ministry of Commerce recently announced the first lot of silver export quota for 2005. According to report, the first lot of silver export quota amounts to 2,443 tons which is 252 tons more on 2004 basis. There are 37 en-

  20. Exports and firm profitability: Quality matters!

    OpenAIRE

    2014-01-01

    This paper uses a tailor-made newly available data set to investigate for the first time the links between profitability and the quality of exports in enterprises from manufacturing industries in Germany, one of the leading actors on the world market for goods. The paper demonstrates that exporters of high-quality goods tend to be more profitable.

  1. 27 CFR 28.123 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.123..., or Transportation to a Manufacturing Bonded Warehouse § 28.123 Export marks. (a) General. In addition... filled under the provisions of part 24 of this chapter, the proprietor shall mark the word “Export” on...

  2. 27 CFR 28.216 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.216... Export marks. In addition to the marks and brands required to be placed on packages or other bulk... “Export” on the Government side of each case or Government head of each container before removal for...

  3. 27 CFR 28.103 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.103... Manufacturing Bonded Warehouse § 28.103 Export marks. (a) General. In addition to the marks and brands required... provisions of part 19 of this chapter, the proprietor shall mark the word “Export” on the Government side of...

  4. 27 CFR 28.144 - Export marks.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Export marks. 28.144... § 28.144 Export marks. (a) General Requirement. In addition to the marks and brands required to be... brewer shall mark the word “Export” on each container or case of beer, or the words “Beer concentrate for...

  5. Export potential of Brazilian industrial firms

    Directory of Open Access Journals (Sweden)

    Bruno César Pino Oliveira de Araújo

    2010-12-01

    Full Text Available Most of the recent astonishing export growth in Brazil came from firms which already exported. The export base was not able to grow at the same pace. Since expanding the export base may have several positive effects on firms' productivity and size, in this paper we provide a four-level classification of Brazilian industrial firms according to their potential to export, and we identify a subset of non-exporting firms which are potential exporters. The effects of export stimulating policies may be improved by focusing more closely on these firms.O recente crescimento das exportações no Brasil se baseou fortemente naquelas firmas já exportadoras, e a base exportadora não conseguiu acompanhar o mesmo ritmo de crescimento. Considerando que expandir a base exportadora pode ter efeitos positivos sobre a produtividade e tamanho das firmas, neste artigo classificamos as firmas industriais brasileiras em quatro níveis de acordo com o potencial exportador, e especialmente identificamos um subconjunto de firmas que não exportam mas que são potenciais exportadoras. Os efeitos das políticas de promoção às exportações podem ser maximizados se elas forem focalizadas nestas firmas.

  6. Textile Exports to Japan Witnessing a Downturn

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    China textile and apparel exports to Japan was witnessing a downturn in all statistics of China Customs and Japan METI in the Jan.-Apr. 2010 period. Exports to Japan this year later will face more pressure as gains in Japan’s consumption could moderate due to a lackluster jobs market and debt crisis.

  7. Export Specialisation and Local Economic Growth

    NARCIS (Netherlands)

    Naude, Wim; Bosker, Maarten; Matthee, Marianne

    This paper aims to provide empirical evidence on whether export specialization or diversification is better for local economic growth. Using export data from 354 magisterial districts of South Africa for 1996 and 2001 we estimate spatial growth regressions that include measures of the degree of

  8. 75 FR 69573 - Export Enforcement Coordination Center

    Science.gov (United States)

    2010-11-15

    ..., employees, or agents, or any other person. (Presidential Sig.) THE WHITE HOUSE, November 9, 2010. [FR Doc... Documents#0;#0; ] Executive Order 13558 of November 9, 2010 Export Enforcement Coordination Center By the... Homeland Security for administrative purposes, an interagency Federal Export Enforcement...

  9. The Plasmodium PHIST and RESA-Like Protein Families of Human and Rodent Malaria Parasites.

    Science.gov (United States)

    Moreira, Cristina K; Naissant, Bernina; Coppi, Alida; Bennett, Brandy L; Aime, Elena; Franke-Fayard, Blandine; Janse, Chris J; Coppens, Isabelle; Sinnis, Photini; Templeton, Thomas J

    2016-01-01

    The phist gene family has members identified across the Plasmodium genus, defined by the presence of a domain of roughly 150 amino acids having conserved aromatic residues and an all alpha-helical structure. The family is highly amplified in P. falciparum, with 65 predicted genes in the genome of the 3D7 isolate. In contrast, in the rodent malaria parasite P. berghei 3 genes are identified, one of which is an apparent pseudogene. Transcripts of the P. berghei phist genes are predominant in schizonts, whereas in P. falciparum transcript profiles span different asexual blood stages and gametocytes. We pursued targeted disruption of P. berghei phist genes in order to characterize a simplistic model for the expanded phist gene repertoire in P. falciparum. Unsuccessful attempts to disrupt P. berghei PBANKA_114540 suggest that this phist gene is essential, while knockout of phist PBANKA_122900 shows an apparent normal progression and non-essential function throughout the life cycle. Epitope-tagging of P. falciparum and P. berghei phist genes confirmed protein export to the erythrocyte cytoplasm and localization with a punctate pattern. Three P. berghei PEXEL/HT-positive exported proteins exhibit at least partial co-localization, in support of a common vesicular compartment in the cytoplasm of erythrocytes infected with rodent malaria parasites.

  10. Plasmodium simium/Plasmodium vivax infections in southern brown howler monkeys from the Atlantic Forest

    Directory of Open Access Journals (Sweden)

    Daniela Camargos Costa

    2014-08-01

    Full Text Available Blood infection by the simian parasite, Plasmodium simium, was identified in captive (n = 45, 4.4% and in wild Alouatta clamitans monkeys (n = 20, 35% from the Atlantic Forest of southern Brazil. A single malaria infection was symptomatic and the monkey presented clinical and haematological alterations. A high frequency of Plasmodium vivax-specific antibodies was detected among these monkeys, with 87% of the monkeys testing positive against P. vivax antigens. These findings highlight the possibility of malaria as a zoonosis in the remaining Atlantic Forest and its impact on the epidemiology of the disease.

  11. 75 FR 11842 - Export Trade Certificate of Review

    Science.gov (United States)

    2010-03-12

    ... the Export Trade Activities and Methods of Operation described below in the following Export Trade and...; foreign trade and business protocol; consulting; market research and analysis; collection of information on trade opportunities; marketing; negotiations; joint ventures; shipping; export management;...

  12. Barriers faced by Romanian SMEs in exporting

    Directory of Open Access Journals (Sweden)

    Dana BOŞCOR

    2017-07-01

    Full Text Available This study aims to identify the most important barriers faced by Romanians SMEs in the process of exporting. The research was based on a focus group including 12 managers from different exporting companies from Brasov. The most important barriers encountered by companies were linked to currency fluctuations, methods of payment, lack of specialized staff, lack of financial resources and a low level of government support. Results from the study revealed that companies should have access at financing in order to invest in new technologies and to create higher quality products that could meet the requirements of the foreign buyers. In order to reduce the export barriers, small and medium sized exporters should create partnerships for reducing the costs of promotion in foreign markets. The government should also increase its support by offering exporters access at financing and market information at lower costs.

  13. The choreography of multidrug export.

    Science.gov (United States)

    Doshi, Rupak; Gutmann, Daniel A P; Khoo, Yvonne S K; Fagg, Lisa A; van Veen, Hendrik W

    2011-06-01

    Multidrug transporters have a crucial role in causing the drug resistance that can arise in infectious micro-organisms and tumours. These integral membrane proteins mediate the export of a broad range of unrelated compounds from cells, including antibiotics and anticancer agents, thus reducing the concentration of these compounds to subtoxic levels in target cells. In spite of intensive research, it is not clear exactly how multidrug transporters work. The present review focuses on recent advancements in the biochemistry and structural biology of bacterial and human multidrug ABC (ATP-binding cassette) transporters. These advancements point to a common mechanism in which polyspecific drug-binding surfaces in the membrane domains are alternately exposed to the inside and outside surface of the membrane in response to the ATP-driven dimerization of nucleotide-binding domains and their dissociation following ATP hydrolysis.

  14. Basal body structure and composition in the apicomplexans Toxoplasma and Plasmodium.

    Science.gov (United States)

    Francia, Maria E; Dubremetz, Jean-Francois; Morrissette, Naomi S

    2015-01-01

    The phylum Apicomplexa encompasses numerous important human and animal disease-causing parasites, including the Plasmodium species, and Toxoplasma gondii, causative agents of malaria and toxoplasmosis, respectively. Apicomplexans proliferate by asexual replication and can also undergo sexual recombination. Most life cycle stages of the parasite lack flagella; these structures only appear on male gametes. Although male gametes (microgametes) assemble a typical 9+2 axoneme, the structure of the templating basal body is poorly defined. Moreover, the relationship between asexual stage centrioles and microgamete basal bodies remains unclear. While asexual stages of Plasmodium lack defined centriole structures, the asexual stages of Toxoplasma and closely related coccidian apicomplexans contain centrioles that consist of nine singlet microtubules and a central tubule. There are relatively few ultra-structural images of Toxoplasma microgametes, which only develop in cat intestinal epithelium. Only a subset of these include sections through the basal body: to date, none have unambiguously captured organization of the basal body structure. Moreover, it is unclear whether this basal body is derived from pre-existing asexual stage centrioles or is synthesized de novo. Basal bodies in Plasmodium microgametes are thought to be synthesized de novo, and their assembly remains ill-defined. Apicomplexan genomes harbor genes encoding δ- and ε-tubulin homologs, potentially enabling these parasites to assemble a typical triplet basal body structure. Moreover, the UNIMOD components (SAS6, SAS4/CPAP, and BLD10/CEP135) are conserved in these organisms. However, other widely conserved basal body and flagellar biogenesis elements are missing from apicomplexan genomes. These differences may indicate variations in flagellar biogenesis pathways and in basal body arrangement within the phylum. As apicomplexan basal bodies are distinct from their metazoan counterparts, it may be possible to

  15. Temporary Expats for Export: Firm-Level Evidence

    OpenAIRE

    Graneli, Anna; Lodefalk, Magnus

    2014-01-01

    We analyze the relation between temporary expats in firms and exports. Temporary expats are positively associated with exports. The within-firmdestination- country link with export intensity is substantially larger for services than for merchandise and for exports of heterogeneous services and merchandise than for exports of homogeneous products. Additionally, the association with exports is stronger for temporary than for permanent expats. Furthermore, our evidence suggests that temporary ex...

  16. Three components model of enterprise’s export activity

    OpenAIRE

    S.A.-A. Al-Osta

    2015-01-01

    The article presents the export activity of the enterprise in the form of structural three components model. It is suggested to include to the model composition such components as pre-export, restructuring / adaptation and export operation. The nature of the given export activities components has been defined. A special role of adaptive changes in the conversion of pre-export to the export operation has been substantiated. The aim of the article. The article is aimed at forming an integrat...

  17. Estimating Trade Elasticities for World Capital Goods Exports

    OpenAIRE

    Thorbecke, Willem

    2012-01-01

    Capital goods exports exceed $3 trillion and are volatile. This paper estimates trade elasticities for capital goods exports. For the UK and the U.S., exports depend on exchange rates. For Germany and France they do not. For Japan, exports to non-Asian countries depend on exchange rates and exports to Asian countries depend on Asia's exports to the rest of the world. For all countries, capital exports depend on GDP in the importing countries. These results imply that U.S. exports tumbled in 2...

  18. Long-term trends in ocean plankton production and particle export between 1960–2006

    Directory of Open Access Journals (Sweden)

    C. Laufkötter

    2013-03-01

    Full Text Available We analyse long-term trends in marine primary and particle export production and their link to marine phytoplankton community composition over the period 1950–2006 using a hindcast simulation of the ocean component of the Community Climate System Model to which the Biogeochemical Elemental Cycling Model had been coupled. In our simulation, global primary and export production decreased by 6% and 7%, respectively over the last 50 yr. These changes go along with a 8% decrease in small phytoplankton biomass and 5% decrease in zooplankton biomass. Diatom biomass decreases by 3% with strong temporal and spatial variability. Strongest decreases in primary and export production occured in the Western Pacific, where increased stratification leads to a decrease in total phytoplankton and a decrease in diatom fraction. This causes decreases in zooplankton biomass and a lower export efficiency. Strong phytoplankton composition changes occur in the Southern Ocean and North Atlantic, where increased wind stress leads to stronger mixing, which reduces the biomass of small phytoplankton, while diatoms profit from higher nutrient inputs and lower grazing pressure. The relative fraction of diatoms correlates positively with the export efficiency (r = 0.8 in most areas except the Northern Pacific and Antarctic Circumpolar Current, where the correlation is negative (r = −0.5. However, long-term trends in global export efficiency are ultimately driven by decreases in small phytoplankton and consequent decreases in coccolithophore biomass.

  19. Mosquito transmission of wild turkey malaria, Plasmodium hermani.

    Science.gov (United States)

    Young, M D; Nayar, J K; Forrester, D J

    1977-04-01

    Culex nigripalpus experimentally transmitted Plasmodium hermani, a plasmodium of wild turkeys (Meleagris gallopavo) in Florida. The mosquitoes were infected by feeding upon blood induced parasitemias in domestic turkey poults. The resulting sporozoites, transmitted by either mosquito bites or injection, produced malaria infections in domestic poults.

  20. Plasmodium vivax induced myocarditis: A rare case report

    Directory of Open Access Journals (Sweden)

    N Gupta

    2013-01-01

    Full Text Available Malaria is one of the commonest parasitic disease in the tropics since ages. However the plasmodium still continues to give surprises to all of us. In the similar context we report a case of Plasmodium vivax induced myocarditis in a 20 year old male and review the literature related to this rare entitiy.

  1. Multiplicity of Infection and Disease Severity in Plasmodium vivax

    DEFF Research Database (Denmark)

    Pacheco, M Andreína; Lopez-Perez, Mary; Vallejo, Andrés F

    2016-01-01

    BACKGROUND: Multiplicity of infection (MOI) refers to the average number of distinct parasite genotypes concurrently infecting a patient. Although several studies have reported on MOI and the frequency of multiclonal infections in Plasmodium falciparum, there is limited data on Plasmodium vivax. ...

  2. Severe sepsis and septic shock due to Plasmodium vivax infection.

    Science.gov (United States)

    Chalkias, Athanasios; Aridas, Sotirios; Karageorgopoulos, Drosos E; Stratiotis, Georgios; Mystrioti, Dimitra; Mallios, Athanasios; Nakos, Ioannis; Mpellos, Nikolaos; Ganotopoulou, Asimina; Xanthos, Theodoros

    2013-04-01

    Plasmodium vivax malaria is typically characterized by a mild and benign clinical course. Organ dysfunction is rarely seen, whereas acute lung injury has been found to occur after starting antimalarial treatment. We present an unusual case of severe sepsis and septic shock due to Plasmodium vivax monoinfection.

  3. Plasmodium vivax cerebral malaria complicated with venous sinus thrombosis in Colombia

    Institute of Scientific and Technical Information of China (English)

    Miguel A Pinzn; Juan C Pineda; Fernando Rosso; Masaru Shinchi; Fabio Bonilla-Abada

    2013-01-01

    Complicated malaria is usually due to Plasmodium falciparum. Nevertheless, Plasmodium vivax is infrequently related with life-threatening complications. Few cases have been reported of severe Plasmodium vivax infection, and most of them from Southeast Asia and India. We report the first case of cerebral malaria due to Plasmodium vivax in Latin America, complicated with sagittal sinus thrombosis and confirmed by a molecular method.

  4. 75 FR 7525 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2010-02-19

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(c) ``Public... fuel France; Belgium. Security Complex, February 2, Uranium (93.35%). uranium (87.3 elements in...

  5. 75 FR 15743 - Application for a License To Export High-Enriched Uranium

    Science.gov (United States)

    2010-03-30

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Application for a License To Export High-Enriched Uranium Pursuant to 10 CFR 110.70(c) ``Public... fabricate fuel France. Complex, March 3, 2010. Uranium (93.35%). uranium (149.36 elements in March 9,...

  6. Construction of living cellular automata using the Physarum plasmodium

    Science.gov (United States)

    Shirakawa, Tomohiro; Sato, Hiroshi; Ishiguro, Shinji

    2015-04-01

    The plasmodium of Physarum polycephalum is a unicellular and multinuclear giant amoeba that has an amorphous cell body. To clearly observe how the plasmodium makes decisions in its motile and exploratory behaviours, we developed a new experimental system to pseudo-discretize the motility of the organism. In our experimental space that has agar surfaces arranged in a two-dimensional lattice, the continuous and omnidirectional movement of the plasmodium was limited to the stepwise one, and the direction of the locomotion was also limited to four neighbours. In such an experimental system, a cellular automata-like system was constructed using the living cell. We further analysed the exploratory behaviours of the plasmodium by duplicating the experimental results in the simulation models of cellular automata. As a result, it was revealed that the behaviours of the plasmodium are not reproduced by only local state transition rules; and for the reproduction, a kind of historical rule setting is needed.

  7. Response to various periods of mechanical stimuli in Physarum plasmodium

    Science.gov (United States)

    Umedachi, Takuya; Ito, Kentaro; Kobayashi, Ryo; Ishiguro, Akio; Nakagaki, Toshiyuki

    2017-06-01

    Response to mechanical stimuli is a fundamental and critical ability for living cells to survive in hazardous conditions or to form adaptive and functional structures against force(s) from the environment. Although this ability has been extensively studied by molecular biology strategies, it is also important to investigate the ability from the viewpoint of biological rhythm phenomena so as to reveal the mechanisms that underlie these phenomena. Here, we use the plasmodium of the true slime mold Physarum polycephalum as the experimental system for investigating this ability. The plasmodium was repetitively stretched for various periods during which its locomotion speed was observed. Since the plasmodium has inherent oscillation cycles of protoplasmic streaming and thickness variation, how the plasmodium responds to various periods of external stretching stimuli can shed light on the other biological rhythm phenomena. The experimental results show that the plasmodium exhibits response to periodic mechanical stimulation and changes its locomotion speed depending on the period of the stretching stimuli.

  8. Mitosis in the Human Malaria Parasite Plasmodium falciparum ▿

    Science.gov (United States)

    Gerald, Noel; Mahajan, Babita; Kumar, Sanjai

    2011-01-01

    Malaria is caused by intraerythrocytic protozoan parasites belonging to Plasmodium spp. (phylum Apicomplexa) that produce significant morbidity and mortality, mostly in developing countries. Plasmodium parasites have a complex life cycle that includes multiple stages in anopheline mosquito vectors and vertebrate hosts. During the life cycle, the parasites undergo several cycles of extreme population growth within a brief span, and this is critical for their continued transmission and a contributing factor for their pathogenesis in the host. As with other eukaryotes, successful mitosis is an essential requirement for Plasmodium reproduction; however, some aspects of Plasmodium mitosis are quite distinct and not fully understood. In this review, we will discuss the current understanding of the architecture and key events of mitosis in Plasmodium falciparum and related parasites and compare them with the traditional mitotic events described for other eukaryotes. PMID:21317311

  9. Identification and Characterization of a Putative Manganese Export Protein in Vibrio cholerae.

    Science.gov (United States)

    Fisher, Carolyn R; Wyckoff, Elizabeth E; Peng, Eric D; Payne, Shelley M

    2016-10-15

    Manganese plays an important role in the cellular physiology and metabolism of bacterial species, including the human pathogen Vibrio cholerae The intracellular level of manganese ions is controlled through coordinated regulation of the import and export of this element. We have identified a putative manganese exporter (VC0022), named mneA (manganese exporter A), which is highly conserved among Vibrio spp. An mneA mutant exhibited sensitivity to manganese but not to other cations. Under high-manganese conditions, the mneA mutant showed an almost 50-fold increase in intracellular manganese levels and reduced intracellular iron relative to those of its wild-type parent, suggesting that the mutant's manganese sensitivity is due to the accumulation of toxic levels of manganese and reduced iron. Expression of mneA suppressed the manganese-sensitive phenotype of an Escherichia coli strain carrying a mutation in the nonhomologous manganese export gene, mntP, further supporting a manganese export function for V. cholerae MneA. The level of mneA mRNA was induced approximately 2.5-fold after addition of manganese to the medium, indicating regulation of this gene by manganese. This study offers the first insights into understanding manganese homeostasis in this important pathogen. Bacterial cells control intracellular metal concentrations by coordinating acquisition in metal-limited environments with export in metal-excess environments. We identified a putative manganese export protein, MneA, in Vibrio cholerae An mneA mutant was sensitive to manganese, and this effect was specific to manganese. The mneA mutant accumulated high levels of intracellular manganese with a concomitant decrease in intracellular iron levels when grown in manganese-supplemented medium. Expression of mneA in trans suppressed the manganese sensitivity of an E. coli mntP mutant. This study is the first to investigate manganese export in V. cholerae. Copyright © 2016, American Society for Microbiology

  10. Structural rationale for the recognition of arginine at P₃ in PEXEL motif containing proteins of Plasmodium falciparum by plasmepsin V.

    Science.gov (United States)

    Guruprasad, Lalitha; Tanneeru, Karunakar; Guruprasad, Kunchur

    2011-06-01

    The virulent form of malaria is caused by Plasmodium falciparum that infects red blood cells. In order to survive inside the host, the parasite remodels the infected erythrocytes by exporting more than 300 effector proteins outside the parasitophorous vacuole membrane into the cytosol. The main feature of all the export proteins is the presence of a pentapeptide sequence motif; RxLxE/Q/D. This sequence motif is hydrolysed between L-x and the proteins with the acetylated new N-terminus xE/Q/D are exported. The enzyme responsible for this hydrolysis is plasmepsin V which is one of the ten aspartic proteases in P. falciparum. In order to understand the structural rationale for the specificity of this protease towards cleavage of the above motif, we generated three-dimensional models of seven plasmepsins (I, V to X) for which experimental structures are not available and compared these along with the crystal structures of three P. falciparum plasmepsins (II to IV). The structure comparisons revealed the importance of Tyr13, Glu77 and Ala117 specific to plasmepsin V that facilitates the accommodation of arginine at P₃ in the RxLxE/Q/D motif. Our analysis correlates the structure-function relationship of plasmepsin V.

  11. EXPORT POTENTIAL OF THE AGRICULTURE OF RUSSIA

    Directory of Open Access Journals (Sweden)

    Klimova N. V.

    2016-05-01

    Full Text Available Export of the food production is undoubtedly one of the most important strategic problems of Russia. The agricultural capacity of our country allows it not only to be fully self-sufficient in terms of food but also turns it into the leading exporter of foodstuffs in the world. The solution of this task requires the effective solution of many problems such as bringing the food industries to a new higher technical and technological level, the creation of the export infrastructure and mechanisms of the financial support to food producers. The fulfilling of the export potential of the domestic agrarian and industrial complex will not only help Russian economy to find the faster way out of the crisis but also will let our country play a major role in the international food trade and, respectively, in the struggle against hunger in the poorest countries of the world. In this article, the essence and the structure of the Russian agricultural export are considered. The three scenarios of the export development (pessimistic, realistic and optimistic and the conditions of their realization are analyzed. The analysis of the main indicators characterizing the current economic state of the agricultural production export is carried out. Based on the drawn conclusions, we have offered the ways of the solution of the given problem

  12. Lithuanian export competitiveness before economic recession

    Directory of Open Access Journals (Sweden)

    Jone Kalendiene

    2011-01-01

    Full Text Available The research paper discusses the concept of competitiveness of economy and analyzes export as an indicator of it. The analysis is started by the historical review of export development. Statistical data show that three Baltic countries have been following different path of export growth since Russian crisis. Different export market orientation and manufacturing sector's longer reorientation process provide an explanation. Furthermore, the historical analysis shows that export growth relation with foreign demand growth and GDP growth is not as strong as it might be expected. In order to estimate possible long-run GDP growth prospects, the structural analysis of trade is performed. The conclusions of the latter revealed high dependence of trade on conjuncture in foreign markets and supported the need of further price and non-price competitiveness analysis. Surprisingly, the results of the former indicate that price indicators do little to explain export development. Conversely, the results of the latter, based on CMSA methodology, show that market orientation of Lithuanian exports adds the most to its competitiveness; meanwhile the product orientation is generally unfavorable. Finally, the relation between FDI structure by countries and trade flows of processed industrial supplies is analyzed. Although data analysis does not reject the existence of such hypothesis, a more detail analysis should be conducted in the future.

  13. The Export Promoting Effect of Emigration

    DEFF Research Database (Denmark)

    Hiller, Sanne

    . This paper provides a first attempt to identify the export-promoting effect of emigration on the firm level. Using detailed Danish firm-level data, we can parsimoniously control for export determinants other than emigration, unobserved heterogeneity at the firm level, as well as for self-selection of firms...... into exporting. Additionally accounting for taste similarity between Denmark and its trade partners, our findings suggest a positive effect of emigration on Danish manufacturing trade within Europe, thereby corroborating preceding studies on aggregate data. Nevertheless, as a novel insight, our analysis reveals...

  14. What's So Special about China's Exports?

    Institute of Scientific and Technical Information of China (English)

    Dani Rodrik

    2006-01-01

    Much more than comparative advantage and free markets have been at play in shaping China's export success. Government policies have helped nurture domestic capabilities in consumer electronics and other advanced areas that would most likely not have developed in their absence. As a result, China has ended up with an export basket that is significantly more sophisticated than what would be normally expected for a country at its income level.This has been an important determinant of China's rapid growth. What matters for China's future growth is not the volume of exports, but whether China will continue to latch on to higher-income products over time.

  15. Second Thoughts on the Exporter Productivity Premium

    DEFF Research Database (Denmark)

    Schröder, Philipp; Sørensen, Allan

    2012-01-01

    Contrary to the prevailing interpretation, this paper shows that the central models of trade with heterogeneous firms [Melitz (2003) and Bernard et al.(2003)] exhibit ambiguous predictions for the exporter productivity premium. This prospect arises due to differences between theoretical and empir......Contrary to the prevailing interpretation, this paper shows that the central models of trade with heterogeneous firms [Melitz (2003) and Bernard et al.(2003)] exhibit ambiguous predictions for the exporter productivity premium. This prospect arises due to differences between theoretical...... for empirical research on exporter performance including learning, and the role of non-parametric regressions (stochastic dominance, quantile regressions), fixed costs and productivity distributions....

  16. Photovoltaic systems for export application. Informal report

    Energy Technology Data Exchange (ETDEWEB)

    Duffy, J.; Campbell, H.; Sajo, A.; Sanz, E. [Univ. of Lowell, MA (United States)

    1988-01-31

    One approach to improving the competitiveness of photovoltaic systems is the development of designs specifically for export applications. In other words, where is it appropriate in a system design to incorporate components manufactured and/or assembled in the receiving country in order to improve the photovoltaic exports from the US? What appears to be needed is a systematic method of evaluating the potential for export from the US of PV systems for various application in different countries. Development of such a method was the goal of this project.

  17. Direct Evidence on Learning by Exporting

    DEFF Research Database (Denmark)

    Grimpe, Christoph; Belderbos, Rene

    2014-01-01

    We examine first direct evidence on the occurrence of learning by exporting, using unique survey data for German innovating firms on the role of (foreign) customers and competitors as sources of ideas and impetus for innovation. Export intensive firms frequently benefit simultaneously from domestic...... learning and export learning – an issue that has been ignored in prior studies. Learning from foreign customers is more prevalent than learning from foreign competitors. Firms’ underlying innovation strategy appears as an important moderator of the propensity to learn and of the relationship between...

  18. Extensive Margins of Offshoring and Exporting

    DEFF Research Database (Denmark)

    Laugesen, Anders Rosenstand

    This paper derives new comparative statics within a two-country version of the recent offshoring model by Antràs, Fort, and Tintelnot (2014) with nonprohibitive costs of exporting final goods. One key finding is that an asymmetric trade liberalisation might very well imply that the fractions...... of offshorers and exporters increase in one country and decrease in the other country. This model outcome occurs when competition enhances in a country experiencing a decline in its costs of international trade. The fractions of offshorers and exporters certainly increase in a small open economy experiencing...

  19. The Competitiveness of Romanian Services Exports

    Directory of Open Access Journals (Sweden)

    Corina Grigorovici

    2008-02-01

    Full Text Available Romania carried on significant progresses in its intercession to fetch up the gaps towards the European Union concerning the services compartment, the balance of those being of almost 10% from the total Romanian export, during the first semester of 2007. In 2006, the export of services increased with 45% comparatively to the year before, consolidating the status of our country as a services exporter. The IT left its mark on the structure and organizing method of the tertiary compartment and ameliorated the form in which the services were performed in the context of enhanced electronic transfers.

  20. Import-push or Export-pull?

    DEFF Research Database (Denmark)

    Jäkel, Ina Charlotte

    2014-01-01

    Does the selection effect of trade work solely through competition from imports, or does the export market further contribute to firm selection? This paper provides a re-interpretation of the different mechanisms in terms of selection on profitability - rather than productivity - and derives novel...... predictions regarding the export market and the role of product differentiation. Empirical results for a sample of Danish manufacturing industries confirm the import- "push" hypothesis as well as the export- "pull" hypothesis, but also reveal differences across industries. The selection effect of trade...

  1. EXPORT STRATEGY BASED ON MARKET RESEARCH

    Directory of Open Access Journals (Sweden)

    Octavian-Liviu OLARU

    2014-05-01

    Full Text Available A strategy is a general plan aimed to develop a business. Even export firm that wants to develop and prosper needs some form of strategy. A company's strategic fit with the trading environment has to be continuously reconsidered because it is likely to erode. Managers should be well informed in order to develop their judgment and understanding of the driving forces that shape the business environment. The greatest mistakes are made by exporters who think they know a foreign market as well as they know their local one, only to find after an ill-fated export launch, that they do not.

  2. Exporting licensing regulations affecting US geothermal firms

    Energy Technology Data Exchange (ETDEWEB)

    1988-08-01

    This document presents a brief introduction and overview of the Department of Commerce's Export Administration Regulations which might affect potential US geothermal goods exporters. It is intended to make US geothermal firms officials aware of the existence of such regulations and to provide them with references, contacts and phone numbers where they can obtain specific and detailed information and assistance. It must be stressed however, that the ultimate responsibility for complying with the above mentioned regulations lies with the exporter who must consult the complete version of the regulations.

  3. How Important is Export-Platform FDI?

    DEFF Research Database (Denmark)

    Geishecker, Ingo; Nielsen, Jørgen Ulff-Møller; Pawlik, Konrad

    on the respective export performance of Polish industries, we suggest a significant role of export-platform FDI into Poland, while the importance of FDI for vertical integration is limited suggesting that the sourcing of intermediate goods from Poland primarily occurs through arm's-length contractual outsourcing...... instead of in-house sourcing of multinational enterprises. The paper also suggests that over the sample period, where Poland has evolved into a relatively stable economic environment, the role of export-platform FDI has increased significantly.  ...

  4. Completing the hypusine pathway in Plasmodium.

    Science.gov (United States)

    Frommholz, David; Kusch, Peter; Blavid, Robert; Scheer, Hugo; Tu, Jun-Ming; Marcus, Katrin; Zhao, Kai-Hong; Atemnkeng, Veronica; Marciniak, Jana; Kaiser, Annette E

    2009-10-01

    In searching for new targets for antimalarials we investigated the biosynthesis of hypusine present in eukaryotic initiation factor-5A (eIF-5A) in Plasmodium. Here, we describe the cloning and expression of deoxyhypusine hydroxylase (DOHH), which completes the modification of eIF-5A through hydroxylation of deoxyhypusine. The dohh cDNA sequence revealed an ORF of 1236 bp encoding a protein of 412 amino acids with a calculated molecular mass of 46.45 kDa and an isoelectric point of 4.96. Interestingly, DOHH from Plasmodium has a FASTA SCORE of only 27 compared with its human ortholog and contains several matches similar to E-Z-type HEAT-like repeat proteins (IPR004155 (InterPro), PF03130 (Pfam), SM00567 (SMART) present in the phycocyanin lyase subunits of cyanobacteria. Purified DOHH protein displayed hydroxylase activity in a novel in vitro DOHH assay, but phycocyanin lyase activity was absent. dohh is present as a single-copy gene and is transcribed in the asexual blood stages of the parasite. A signal peptide at the N-terminus might direct the protein to a different cellular compartment. During evolution, Plasmodium falciparum acquired an apicoplast that lost its photosynthetic function. It is possible that plasmodial DOHH arose from an E/F-type phycobilin lyase that gained a new role in hydroxylation. Structured digital abstract: * MINT-7255047: DHS (uniprotkb:P49366) enzymaticly reacts (MI:0414) with eIF-5A (uniprotkb:Q710D1) by enzymatic studies (MI:0415) * MINT-7255326: DOHH (uniprotkb:Q8I701) enzymaticly reacts (MI:0414) with eIF-5A (uniprotkb:Q710D1) by enzymatic studies (MI:0415).

  5. Prevalence of Malaria Plasmodium in Abeokuta, Nigeria

    Directory of Open Access Journals (Sweden)

    Okonko, I. O.

    2009-01-01

    Full Text Available This study reports the prevalence of malaria caused by plasmodium between genders in Abeokuta, the capital city of Ogun State located in the forest zone of southwestern Nigeria between January 2002 and December 2004. Blood film examination for malaria parasites in 708 patients; 366 males and 342 females. Microscopic examination of thick films techniques was employed for this study. Of the 708 (100% patients examined, 577 (81.5% were Plasmodium-positive. A high malaria parasite prevalence rate of 81.5% was noted in this study. Female subjects were more infected (42.4% than males (41.9% however, there was no significant difference in the sex of the subjects studied (p=0.05. A high malaria parasite prevalence rate of 86.9% was noted in samples collected in year 2003 than in other years studied. There was significant difference in the years under study (p=0.05. This study shows that a good percentage of people were infested by malaria Plasmodium. This could be attributed to lack of adequate accommodation and poor sanitary conditions in the area under study. Although several efforts have been made to effectively control the high incidence of malaria in Nigeria, these have been largely unsuccessful due to a number of reasons such as irrigated urban agriculture which can be the malaria vector’s breeding ground in the city, stagnant gutters and swamps in our environment where mosquitoes breed in millions, and lack of political will and commitment of the government in its disease management program, low awareness of the magnitude of malaria problem, poor health practices by individuals and communities and resistance to drugs. Therefore, future interventions in Nigeria should be directed toward controlling malaria in the context of a moderate transmission setting; thus, large-scale distribution of insecticide-treated nets or widespread use of indoor residual spraying may be less cost-effective than enhanced surveillance with effective case management or

  6. Companies Export Function: Identifying the Effects of Perceived Competitive Advantages, Adapting Marketing Tactics and Exporting Experience on Export Function

    Directory of Open Access Journals (Sweden)

    S. Y. Hosseini

    2011-01-01

    Full Text Available Information and communication technology (ICT has intensively affected the quality and quantity of competition among companies in their accessibility to the markets of other countries during the last two decades. The basic question that every company working in the international markets has faced with is the factors affecting export function. This study is conducted for the purpose of answering this question. Reviewing the related literature shows that among many factors which may affect export function, adapting marketing tactics, export experience, and perceived competitive advantage are the most remarkable ones. Based on this theoretical finding, the conceptual model of the research had created and five hypotheses were tested during this study. For adopting experimental data with the conceptual model, export companies in Fars province have been studied. Findings illustrate that four out of five hypotheses of the research have approved and only the direct relationship of marketing tactics adaption with export function has not been verified. The effect of marketing tactics adoption to export function was indirect and obtained through perceived competitive advantage as an intermediary variable.

  7. Companies Export Function: Identifying the Effects of Perceived Competitive Advantages, Adapting Marketing Tactics and Exporting Experience on Export Function

    Directory of Open Access Journals (Sweden)

    Yaghoub Hossainee

    2011-07-01

    Full Text Available Abstract Information and communication technology (ICT has intensively affected the quality and quantity of competition among companies in their accessibility to the markets of other countries during the last two decades. The basic question that every company working in the international markets has faced with is the factors affecting export function. This study is conducted for the purpose of answering this question. Reviewing the related literature shows that among many factors which may affect export function, adapting marketing tactics, export experience, and perceived competitive advantage are the most remarkable ones. Based on this theoretical finding, the conceptual model of the research had created and five hypotheses were tested during this study. For adopting experimental data with the conceptual model, export companies in Fars province have been studied. Findings illustrate that four out of five hypotheses of the research have approved and only the direct relationship of marketing tactics adaption with export function has not been verified. The effect of marketing tactics adoption to export function was indirect and obtained through perceived competitive advantage as an intermediary variable.

  8. Gametocitos de Plasmodium vivax y Plasmodium falciparum: etapas relegadas en el desarrollo de vacunas Plasmodium vivax and Plasmodium falciparum gametocyte stages are neglected in vaccine development

    Directory of Open Access Journals (Sweden)

    Carla Contreras-Ochoa

    2004-02-01

    Full Text Available Los gametocitos de Plasmodium son los responsables de la transmisión del huésped vertebrado al mosquito vector. Sufren un proceso de desarrollo complejo a partir de parásitos asexuales, que no está completamente entendido, expresando proteínas y moléculas de adhesión específicas. Son capaces de inducir una respuesta inmune humoral específica con anticuerpos IgG, y celular específica, con producción de TNFa, IFNg y proliferación de linfocitos gd+, aun cuando existen respuestas inducidas en contra de las etapas previas del parásito (esporozoito, exo-eritrocítica y eritrocítica. Las vacunas destinadas a bloquear la transmisión del parásito no contemplan a los gametocitos circulantes en el huésped como blancos de acción, sino que van enfocadas contra antígenos expresados en los gametos y en las etapas posfertilización. El estudio de los mecanismos que regulan la producción de gametocitos y de la respuesta inmune contra éstos, ofrece una oportunidad para el desarrollo de estrategias adicionales para el control de la transmisión.Plasmodium gametocytes are responsible for transmission from the vertebrate host to the mosquito. Plasmodium gametocytes undergo a complex cycle from asexual stages, through a poorly understood process characterized by expression of stage-specific proteins and adhesion molecules. Gametocytes are capable of inducing specific humoral IgG, and cellular responses, which include induction of TNFa, IFNg and gd+ lymphocyte proliferation, in addition to immune responses to other stages of the parasite (sporozoite, exo-erythrocytic stages, erythrocytic stages. Although transmission-blocking vaccines against Plasmodium do not currently include components against the gametocytes (rather they focus on gametes, zygotes or ookinetes, stages which occur in the mosquito, further understanding of the mechanisms underlying gametocytogenesis and immune responses against these stages may provide additional strategies for

  9. Gametocitos de Plasmodium vivax y Plasmodium falciparum: etapas relegadas en el desarrollo de vacunas Plasmodium vivax and Plasmodium falciparum gametocyte stages are neglected in vaccine development

    OpenAIRE

    Carla Contreras-Ochoa; Ramsey, Janine M.

    2004-01-01

    Los gametocitos de Plasmodium son los responsables de la transmisión del huésped vertebrado al mosquito vector. Sufren un proceso de desarrollo complejo a partir de parásitos asexuales, que no está completamente entendido, expresando proteínas y moléculas de adhesión específicas. Son capaces de inducir una respuesta inmune humoral específica con anticuerpos IgG, y celular específica, con producción de TNFa, IFNg y proliferación de linfocitos gd+, aun cuando existen respuestas inducidas en con...

  10. Export of electronics equipment waste.

    Science.gov (United States)

    LaDou, Joseph; Lovegrove, Sandra

    2008-01-01

    Electronics equipment waste ("e-waste") includes discarded computers, computer monitors, television sets, and cell phones. Less than 10% of e-waste is currently recycled. The United States and other developed countries export e-waste primarily to Asia, knowing it carries a real harm to the poor communities where it will be discarded. A 2006 directive bans the use of lead, mercury, cadmium, hexavalent chromium, and certain brominated flame retardants in most electronics products sold in the EU. A similar directive facilitates the development and design of clean electronics products with longer lifespans that are safe and easy to repair, upgrade, and recycle, and will not expose workers and the environment to hazardous chemicals. These useful approaches apply only regionally and cover only a fraction of the hazardous substances used in electronics manufacture, however. There is an urgent need for manufacturers of electronics products to take responsibility for their products from production to end-of-life, and for much tighter controls both on the transboundary movement of e-waste and on the manner in which it is recycled. Manufacturers must develop clean products with longer lifespans that are safe and easy to repair, upgrade, and recycle and will not expose workers and the environment to hazardous chemicals.

  11. Import & Export Tariff Changes in 2007

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Since January 1st, 2007, the Program for Implementation of Tariffs in 2007 has become effective. The Customs Tariff Commission of the State Council has made many modifications on the implementation of import and export tariffs as following:

  12. An Export Promotion Policy after Financial Crisis

    Directory of Open Access Journals (Sweden)

    Ingyo Cheong

    1998-09-01

    Full Text Available Although the Korean government puts in place various export support policies after the financial crisis, Korean export is still in stagnation because the foreign-oriented economic conditions, such as the continual ripple effect of the Eastern Asia financial crisis and the American economy which is slowing down, are deteriorating. After the financial crisis, Korean trading circle considered the difficulties in financing and the buying of raw material to be the most important factors which blocked the export. This thesis first analyzed the change of the actual export results, then analyzed the policy the government brought forward as the solution of the difficulties in financing and raw material buying. Meanwhile, this thesis brought forward alternative policies like taking auto-rediscount and signing Free Trade Agreement with major trade states.

  13. Import-push or Export-pull?

    DEFF Research Database (Denmark)

    Jäkel, Ina Charlotte

    2014-01-01

    Does the selection effect of trade work solely through competition from imports, or does the export market further contribute to firm selection? This paper provides a re-interpretation of the different mechanisms in terms of selection on profitability - rather than productivity - and derives novel...... predictions regarding the export market and the role of product differentiation. Empirical results for a sample of Danish manufacturing industries confirm the import- "push" hypothesis as well as the export- "pull" hypothesis, but also reveal differences across industries. The selection effect of trade...... is mainly driven by the "import-push" if product differentiation is high, whereas it is driven by the "export-pull" if goods are homogeneous....

  14. Import-push or Export-pull?

    DEFF Research Database (Denmark)

    Jäkel, Ina Charlotte

    Does the selection effect of trade work solely through competition from imports, or does the export market further contribute to firm selection? This paper provides a re-interpretation of the different mechanisms in terms of selection on profitability - rather than productivity - and derives novel...... predictions regarding the export market and the role of product differentiation. Empirical results for a sample of Danish manufacturing industries confirm the import-"push" hypothesis as well as the export-"pull" hypothesis, but also reveal differences across industries. The selection effect of trade...... is mainly driven by the "import-push" if product differentiation is high, whereas it is driven by the "export-pull" if goods are homogeneous....

  15. 78 FR 54238 - President's Export Council; Meeting

    Science.gov (United States)

    2013-09-03

    ... minimis reform; intellectual property protections in the Trans-Pacific Partnership agreement; expansion of the Information Technology Agreement; and export control reform. The final agenda will be posted at...

  16. Analysis on China's Motorcycle Product Export

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ From 1958 till now, from copying the Soviet BMW-originated 750cc horizontal-opposed engine to becoming the biggest motorcycle manufacturing and exporting country,China's motorcycle industry had gonethrough a prosperous course of 48 years.

  17. The novel oxygenated chalcone, 2,4-dimethoxy-4'-butoxychalcone, exhibits potent activity against human malaria parasite Plasmodium falciparum in vitro and rodent parasites Plasmodium berghei and Plasmodium yoelii in vivo

    DEFF Research Database (Denmark)

    Chen, M; Brøgger Christensen, S; Zhai, L

    1997-01-01

    growth of both a chloroquine-susceptible (3D7) and a chloroquine-resistant (Dd2) strain of Plasmodium falciparum in a [3H]hypoxanthine uptake assay. The in vivo activity of 2,4mbc was tested in mice infected with Plasmodium berghei or Plasmodium yoelii and in rats infected with P. berghei. 2,4mbc...

  18. Contributions to improve accounting and financial reporting of exports of goods and services

    Directory of Open Access Journals (Sweden)

    Nicolae Paul Virag

    2012-01-01

    Full Text Available Foreign trade is a form of foreign economic activity and simultaneously a form of trade in general. Basic forms of trade determines the existence of their methodology to account for flows. At the first level of imports and exports accounting methodology is based on general patterns of purchases and sales records locally, but is supplemented with specific elements of the tax, customs and currency. This paper proposes an approach to exports of goods and services in terms of accounting and taxation.

  19. 7 CFR 1493.80 - Evidence of export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Evidence of export. 1493.80 Section 1493.80... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Export Credit Guarantee Program (GSM-102) and CCC Intermediate Export Credit Guarantee Program...

  20. 7 CFR 1493.470 - Evidence of export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Evidence of export. 1493.470 Section 1493.470... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Supplier Credit Guarantee Program Operations § 1493.470 Evidence of export. (a) Report of export....

  1. 7 CFR 35.8 - Date of export.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Date of export. 35.8 Section 35.8 Agriculture... Practices), DEPARTMENT OF AGRICULTURE COMMODITY STANDARDS AND STANDARD CONTAINER REGULATIONS EXPORT GRAPES AND PLUMS Definitions § 35.8 Date of export. Date of export means the date of loading on board...

  2. 40 CFR 725.920 - Exports and imports.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Exports and imports. 725.920 Section... on Significant New Uses of Microorganisms § 725.920 Exports and imports. (a) Exports. Persons who intend to export a microorganism identified in subpart M of this part, or in any proposed rule...

  3. 77 FR 53865 - Export Trade Certificate of Review

    Science.gov (United States)

    2012-09-04

    ... International Trade Administration Export Trade Certificate of Review ACTION: Notice of issuance of an Export Trade Certificate of Review to Colombia Poultry Export Quota, Inc. (``COLOM-PEQ)'') (Application 12-00004). SUMMARY: On August 14, 2012, the U.S. Department of Commerce issued an Export Trade Certificate...

  4. 76 FR 27994 - Export Trade Certificate of Review

    Science.gov (United States)

    2011-05-13

    ... International Trade Administration Export Trade Certificate of Review ACTION: Notice of Application (84-22A12) to Amend the Export Trade Certificate of Review Issued to Northwest Fruit Exporters, Application No... Trade Administration, Department of Commerce, has received an application to amend an Export Trade...

  5. 7 CFR 1493.280 - Evidence of export report.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Evidence of export report. 1493.280 Section 1493.280... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Facility Guarantee Program (FGP) Operations § 1493.280 Evidence of export report. (a) Report of export. The...

  6. 75 FR 65449 - Export Trade Certificate of Review

    Science.gov (United States)

    2010-10-25

    ... International Trade Administration Export Trade Certificate of Review ACTION: Notice of issuance of an amended export trade certificate of review to Florida Citrus Exports L.C. (``FCE'') (Application 94-4A007). SUMMARY: The U.S. Department of Commerce issued an amended Export Trade Certificate of Review to Florida...

  7. 77 FR 61744 - Export Trade Certificate of Review

    Science.gov (United States)

    2012-10-11

    ... International Trade Administration Export Trade Certificate of Review ACTION: Notice of Issuance of an Export... September 27, 2012, the U.S. Department of Commerce issued an amended Export Trade Certificate of Review to... INFORMATION: Title III of the Export Trading Company Act of 1982 (15 U.S.C. 4001-21) authorizes the Secretary...

  8. 9 CFR 322.3 - Transferring products for export.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Transferring products for export. 322... INSPECTION AND CERTIFICATION EXPORTS 1 § 322.3 Transferring products for export. When inspected and passed products for export are transferred from tank cars to other containers on vessels, such transfer shall be...

  9. 19 CFR 113.55 - Cancellation of export bonds.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Cancellation of export bonds. 113.55 Section 113... export bonds. (a) Manner of cancellation. A bond to assure exportation as defined in § 101.1 of this... shall be signed by a revenue officer of the foreign country to which the merchandise is exported, unless...

  10. 77 FR 2036 - Export Trade Certificate of Review

    Science.gov (United States)

    2012-01-13

    ... International Trade Administration Export Trade Certificate of Review ACTION: Notice of issuance of an Export...). SUMMARY: The U.S. Department of Commerce issued an amended Export Trade Certificate of Review to Aerospace... Register on December 7, 2010 (75 FR 75963). The original Export Trade Certificate of Review No. 92-0001 was...

  11. 78 FR 59004 - Export Trade Certificate of Review

    Science.gov (United States)

    2013-09-25

    ... International Trade Administration Export Trade Certificate of Review ACTION: Notice of Application for an Export Trade Certificate of Review to Emporia Trading LLC, Application No. 13-00001. SUMMARY: The Export... Administration, Department of Commerce, has received an application for an Export Trade Certificate of Review...

  12. 75 FR 8040 - Export Trade Certificate of Review

    Science.gov (United States)

    2010-02-23

    ... International Trade Administration Export Trade Certificate of Review ACTION: Notice of Application for an Export Trade Certificate of Review from Alaska Longline Cod Commission (``ALCC'') SUMMARY: The Export... Administration, Department of Commerce, has received an application for an Export Trade Certificate of Review...

  13. 7 CFR 51.2840 - Export packing requirements.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Export packing requirements. 51.2840 Section 51.2840...) Export Packing Requirements § 51.2840 Export packing requirements. Onions specified as meeting Export Packing Requirements shall be packed in containers having a net capacity of 25 kilograms (approximately...

  14. Are there regional differences in US hardwood product exports?

    Science.gov (United States)

    Matt Bumgardner; Scott Bowe; William Luppold

    2016-01-01

    Exporting is a critical component of the product mix for many domestic hardwood firms. Previous research has identified factors associated with hardwood lumber exporting behavior, but less is known about the advantages and disadvantages to exporting associated with the region within which a firm is located, or about exporting of secondary hardwood products. A procedure...

  15. 27 CFR 44.111 - Change in export warehouse premises.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Change in export warehouse... Qualification of Export Warehouse Proprietors Changes in Location and Premises § 44.111 Change in export warehouse premises. Where an export warehouse is to be changed to an extent which will make inaccurate...

  16. 76 FR 13127 - Action Affecting Export Privileges; Amy Farrow

    Science.gov (United States)

    2011-03-10

    ... Bureau of Industry and Security Action Affecting Export Privileges; Amy Farrow In the Matter of: Amy... Export Administration Regulations (the ``Regulations'') \\1\\ and Section 13(c) of the Export... Emergency Economic Powers Act (50 U.S.C. 1701 et seq.). Charges 1-116 15 CFR 764.2(a): Exporting Stun...

  17. 77 FR 59591 - Export Trade Certificate of Review

    Science.gov (United States)

    2012-09-28

    ..., Suppliers or other persons based on orders, export markets, territories, customers, or any other basis Sun... exclusively in a particular export market for the export of Products; 13. Enter into agreements with customers in the Export Markets in which the customer may agree to purchase Products exclusively from...

  18. 19 CFR 12.125 - Notice of exportation.

    Science.gov (United States)

    2010-04-01

    ... following information in the notice of exportation: (a) The name and address of the exporter or his agent... 19 Customs Duties 1 2010-04-01 2010-04-01 false Notice of exportation. 12.125 Section 12.125... § 12.125 Notice of exportation. Whenever the Administrator directs the port director to refuse...

  19. 19 CFR 122.94 - Certificate of lading for exportation.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 1 2010-04-01 2010-04-01 false Certificate of lading for exportation. 122.94....94 Certificate of lading for exportation. (a) Required filing. This section applies to merchandise entered for transportation and exportation by aircraft. A certificate of lading for exportation and...

  20. 19 CFR 18.44 - Abandonment of exportation.

    Science.gov (United States)

    2010-04-01

    ... Control Exported Under Cover of A Tir Carnet § 18.44 Abandonment of exportation. In the event that exportation is abandoned at any time after merchandise has been placed under cover of a TIR carnet, the... 19 Customs Duties 1 2010-04-01 2010-04-01 false Abandonment of exportation. 18.44 Section...

  1. 22 CFR 123.17 - Exports of firearms and ammunition.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Exports of firearms and ammunition. 123.17... FOR THE EXPORT OF DEFENSE ARTICLES § 123.17 Exports of firearms and ammunition. (a) Except as provided... export without a license of components and parts for Category I(a) firearms, except barrels,...

  2. 22 CFR 125.2 - Exports of unclassified technical data.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Exports of unclassified technical data. 125.2... THE EXPORT OF TECHNICAL DATA AND CLASSIFIED DEFENSE ARTICLES § 125.2 Exports of unclassified technical data. (a) License. A license (DSP-5) is required for the export of unclassified technical data...

  3. 78 FR 79018 - Request for a License To Export Deuterium

    Science.gov (United States)

    2013-12-27

    ... COMMISSION Request for a License To Export Deuterium Pursuant to 10 CFR 110.70 (b) ``Public Notice of Receipt... received the following request for an export license. Copies of the request are available electronically.... The information concerning this export license application follows. ] NRC Export License...

  4. 75 FR 35441 - Export Trade Certificate of Review

    Science.gov (United States)

    2010-06-22

    ... International Trade Administration Export Trade Certificate of Review ACTION: Notice of Issuance ( 99-4A005) of an Amended Export Trade Certificate of Review to the California Almond Export Association, LLC. SUMMARY: The U.S. Department of Commerce issued an amended Export Trade Certificate of Review to...

  5. 14 CFR 21.325 - Export airworthiness approvals.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Export airworthiness approvals. 21.325... AIRCRAFT CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Export Airworthiness Approvals § 21.325 Export airworthiness approvals. (a) Kinds of approvals. (1) Export airworthiness approval of Class I products is...

  6. 48 CFR 1852.225-70 - Export Licenses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Export Licenses. 1852.225... 1852.225-70 Export Licenses. As prescribed in 1825.1103-70(b), insert the following clause: Export Licenses (FEB 2000) (a) The Contractor shall comply with all U.S. export control laws and...

  7. 22 CFR 120.30 - The Automated Export System (AES).

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false The Automated Export System (AES). 120.30... DEFINITIONS § 120.30 The Automated Export System (AES). The Automated Export System (AES) is the Department of... system for collection of export data for the Department of State. In accordance with this subchapter...

  8. 26 CFR 1.970-1 - Export trade corporations.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 10 2010-04-01 2010-04-01 false Export trade corporations. 1.970-1 Section 1... (CONTINUED) INCOME TAXES Export Trade Corporations § 1.970-1 Export trade corporations. (a) In general. Sections 970 through 972 provide in general that if a controlled foreign corporation is an export...

  9. Productivity, Exporting and the Learning-by-Exporting Hypothesis: Direct Evidence from UK Firms

    OpenAIRE

    Crespi, Gustavo; Criscuolo, Chiara; Haskel, Jonathan

    2006-01-01

    Case study evidence suggests that exporting firms learn from their clients. But econometric evidence, mostly using exporting and TFP growth, is mixed. We use a UK panel data set with firm-level information on exporting and productivity. Our innovation is that we also have direct data on the sources of learning (in this case about new technologies). Controlling for fixed effects we have two main findings. First, we find firms who exported in the past are more likely to then report that they le...

  10. SMEs in Argentina: Who are the Exporters?

    OpenAIRE

    Ottaviano, Gianmarco I.P.; Martincus, Christian Volpe

    2009-01-01

    There exists a growing body of literature which looks at export decisions made by firms. Most studies focus on developed countries and do not explore whether different behavioral patterns prevail over the firm size distribution. This paper aims at filling this gap in the literature by analyzing the export behavior of a statistically representative sample of 192 Small and Medium-Size Enterprises (SMEs) in a developing country, Argentina, over the period 1996-1998. We find that the level of emp...

  11. Two Contrasting Phenomena in Textile Exports

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ As the two traditional markets for China's textile and clothing exports,the U.S.and Europe have recently shown a huge contrast. The 103rd China Import and Export Fair,also known as the Canton Fair,the largest trade fair in China,has closed its closed its doors,impacted by the rising costs of raw materials,appreciation of the RMB,decreased demand from U.S.customers and other factors.

  12. Direction of Exports of Commercial Agricultural Commodities

    OpenAIRE

    2005-01-01

    Agricultural commodities like tea, coffee, spices, oilseeds, cotton and cashew can be grouped under cash crops. They are traditional export items, which aggregate to 50% of total agricultural exports by India. These items are ready for consumption after some value addition. They are used as raw material in food and other industries. The commodities can be ranked high in hierarchy of demands after food items like wheat and rice. The economic status of the consumer plays a significant role in t...

  13. Textile Machinery Import and Export in 2011

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    Along with the rebounded international market, in the year of 2011, the foreign trade of textile machinery industry preserved a stable development: the import amount saw a slightly decrease, while the total import and export value kept an increasing trend. According to the Customs, the export and import of textile machinery totalized 2.245 billion USD and 5.364 billion USD, increasing by 27.81% and 24.70%, respectively, comparing with the same period of time in 2010.

  14. Croatia:Promote More Exports to China

    Institute of Scientific and Technical Information of China (English)

    Liu; Yun

    2005-01-01

      Croatia, a transitional country, is lo cated both in mid-Europe and Mediterranean, which boasts inborn geographical advantages. It is currently undergoing dynamic changes in its economic and social structure. Among the reform, it focuses on enlarging exports,especially the export to China, the world large and potential market. In this regard,recently, our report interviewed H.E.Boris Velic, Ambassador of Croatia to China.……

  15. Croatia:Promote More Exports to China

    Institute of Scientific and Technical Information of China (English)

    Liu Yun

    2005-01-01

    @@ Croatia, a transitional country, is lo cated both in mid-Europe and Mediterranean, which boasts inborn geographical advantages. It is currently undergoing dynamic changes in its economic and social structure. Among the reform, it focuses on enlarging exports,especially the export to China, the world large and potential market. In this regard,recently, our report interviewed H.E.Boris Velic, Ambassador of Croatia to China.

  16. Diagnostics of the Enterprise Export Potential

    OpenAIRE

    Skrynkovskyy Ruslan M.; Klyuvak Oksana V.; Protsevyat Oksana S.

    2016-01-01

    The aim of the article is to form and develop theoretical and methodological foundations for diagnostics of the enterprise export potential, which should be understood as a process of identification, analysis and assessment of the level of potential possibility and readiness of the enterprise to implement export activities taking into account the impact of interrelated internal variables (goals, technology, structure, tasks, educational and professional potential of the staf...

  17. Exporter Price Response to Exchange Rate Changes

    DEFF Research Database (Denmark)

    Fosse, Henrik Barslund

    Firms exporting to foreign markets face a particular challenge: to price their exports in a foreign market when the exchange rate changes. This paper takes on pricing- to-market using a unique data set that covers rm level monthly trade at great detail. As opposed to annual trade ows, monthly trade...... theoretical contributions to the litterature on pricing-to-market and exchange rate pass-through....

  18. Industrial Forecasts after Export Rebates Adjustment

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ On June 19, 2007, the Circular of the Ministry of Finance and the State Administration of Taxation concerning Lowering the Export Rebate Rates for Some Commodities was published, which finally proved the early rumor of tax rebate adjustment to be true.According to the Circular, the export rebate rates for some commodities have been adjusted upon approval of the State Council and the new rates have become in force since July 1, 2007.

  19. No evidence for ape Plasmodium infections in humans in Gabon.

    Science.gov (United States)

    Délicat-Loembet, Lucresse; Rougeron, Virginie; Ollomo, Benjamin; Arnathau, Céline; Roche, Benjamin; Elguero, Eric; Moukodoum, Nancy Diamella; Okougha, Alain-Prince; Mve Ondo, Bertrand; Boundenga, Larson; Houzé, Sandrine; Galan, Maxime; Nkoghé, Dieudonné; Leroy, Eric M; Durand, Patrick; Paupy, Christophe; Renaud, François; Prugnolle, Franck

    2015-01-01

    African great apes are naturally infected by a multitude of Plasmodium species most of them recently discovered, among which several are closely related to human malaria agents. However, it is still unknown whether these animals can serve as source of infections for humans living in their vicinity. To evaluate this possibility, we analysed the nature of Plasmodium infections from a bank of 4281 human blood samples collected in 210 villages of Gabon, Central Africa. Among them, 2255 were detected positive to Plasmodium using molecular methods (Plasmodium Cytochrome b amplification). A high throughput sequencing technology (454 GS-FLX Titanium technology, Roche) was then used to identify the Plasmodium species present within each positive sample. Overall, we identified with confidence only three species infecting humans in Gabon: P. falciparum, P. malariae and P. ovale. None of the species known to infect non-human primates in Central Africa was found. Our study shows that ape Plasmodium parasites of the subgenus Laverania do not constitute a frequent source of infection for humans. It also suggests that some strong host genetic barriers must exist to prevent the cross species transmission of ape Plasmodium in a context of ever increasing contacts between humans and wildlife.

  20. Prevalence and distribution of human Plasmodium infection in Pakistan.

    Science.gov (United States)

    Khattak, Aamer A; Venkatesan, Meera; Nadeem, Muhammad F; Satti, Humayoon S; Yaqoob, Adnan; Strauss, Kathy; Khatoon, Lubna; Malik, Salman A; Plowe, Christopher V

    2013-08-28

    Both Plasmodium vivax and Plasmodium falciparum are prevalent in Pakistan, yet up-to-date data on the epidemiology of malaria in Pakistan are not available. This study was undertaken to determine the current prevalence and distribution of Plasmodium species across the country. A malariometric population survey was conducted in 2011 using blood samples collected from 801 febrile patients of all ages in four provinces and the capital city of Islamabad. Microscopically confirmed Plasmodium-positive blood samples were reconfirmed by polymerase chain reaction (PCR). Confirmed parasite-positive samples were subjected to species-specific PCR capable of detecting four species of human malaria. Of the 707 PCR-positive samples, 128 (18%) were P. falciparum, 536 (76%) were P. vivax, and 43 (6%) were mixed P. falciparum and P. vivax. Ninety-four microscopy-positive samples were PCR-negative, and Plasmodium malariae and Plasmodium ovale were not detected. Prevalence of P. vivax ranged from 2.4% in Punjab Province to 10.8% in Sindh Province and prevalence of P. falciparum ranged from 0.1% in Islamabad to 3.8% in Balochistan. Plasmodium infections in Pakistan are largely attributed to P. vivax but P. falciparum and mixed species infections are also prevalent. In addition, regional variation in the prevalence and species composition of malaria is high.

  1. Plasmodium infection decreases fecundity and increases survival of mosquitoes.

    Science.gov (United States)

    Vézilier, J; Nicot, A; Gandon, S; Rivero, A

    2012-10-07

    Long-lived mosquitoes maximize the chances of Plasmodium transmission. Yet, in spite of decades of research, the effect of Plasmodium parasites on mosquito longevity remains highly controversial. On the one hand, many studies report shorter lifespans in infected mosquitoes. On the other hand, parallel (but separate) studies show that Plasmodium reduces fecundity and imply that this is an adaptive strategy of the parasite aimed at redirecting resources towards longevity. No study till date has, however, investigated fecundity and longevity in the same individuals to see whether this prediction holds. In this study, we follow for both fecundity and longevity in Plasmodium-infected and uninfected mosquitoes using a novel, albeit natural, experimental system. We also explore whether the genetic variations that arise through the evolution of insecticide resistance modulate the effect of Plasmodium on these two life-history traits. We show that (i) a reduction in fecundity in Plasmodium-infected mosquitoes is accompanied by an increase in longevity; (ii) this increase in longevity arises through a trade-off between reproduction and survival; and (iii) in insecticide-resistant mosquitoes, the slope of this trade-off is steeper when the mosquito is infected by Plasmodium (cost of insecticide resistance).

  2. Identification of a novel and unique transcription factor in the intraerythrocytic stage of Plasmodium falciparum.

    Directory of Open Access Journals (Sweden)

    Kanako Komaki-Yasuda

    Full Text Available The mechanisms of stage-specific gene regulation in the malaria parasite Plasmodium falciparum are largely unclear, with only a small number of specific regulatory transcription factors (AP2 family having been identified. In particular, the transcription factors that function in the intraerythrocytic stage remain to be elucidated. Previously, as a model case for stage-specific transcription in the P. falciparum intraerythrocytic stage, we analyzed the transcriptional regulation of pf1-cys-prx, a trophozoite/schizont-specific gene, and suggested that some nuclear factors bind specifically to the cis-element of pf1-cys-prx and enhance transcription. In the present study, we purified nuclear factors from parasite nuclear extract by 5 steps of chromatography, and identified a factor termed PREBP. PREBP is not included in the AP2 family, and is a novel protein with four K-homology (KH domains. The KH domain is known to be found in RNA-binding or single-stranded DNA-binding proteins. PREBP is well conserved in Plasmodium species and partially conserved in phylum Apicomplexa. To evaluate the effects of PREBP overexpression, we used a transient overexpression and luciferase assay combined approach. Overexpression of PREBP markedly enhanced luciferase expression under the control of the pf1-cys-prx cis-element. These results provide the first evidence of a novel transcription factor that activates the gene expression in the malaria parasite intraerythrocytic stage. These findings enhance our understanding of the evolution of specific transcription machinery in Plasmodium and other eukaryotes.

  3. Sudanese live sheep and mutton exports competitiveness

    Directory of Open Access Journals (Sweden)

    Babiker Idris Babiker

    2011-01-01

    Full Text Available The livestock sector of Sudan provides livelihood for about 17% of the population. Sudanese livestock products meet the domestic demand for meat in addition to a substantial excess for export amounting to about 22% of total country exports. It contributes about 19% of GDP. Sheep marketing in Sudan is characterised by traditional operations and is informally organised, although, recently there are great efforts by the formal livestock authorities to organise some secondary and terminal livestock markets. These markets are deficient in basic infrastructures and systematic marketing research. The system as a whole is faced by various complex obstacles and constraints, which decrease the contribution of livestock in general, and sheep in particular, to the national economy, and suppress the optimum exploitation of this resource. These obstacles are represented in the lack of transportation networks that connect the production and consumption centres to break the seasonality of supply that creates shortages and high prices at the consumption centres. This paper employs the policy analysis matrix (PAM technique to examine the Sudanese live sheep and mutton competitiveness in the international market. The results indicated that the market price was greater than the border price implying a positive incentive as an implicit subsidy to the live sheep exporter. The mutton exporters were found subsidised as well. The international value added (IVA indicted a positive foreign exchange earnings or savings. Exported live sheep and mutton coefficient of competitiveness (CIC implied that sheep and mutton exports are profitable and internationally competitive.

  4. Export-led Growth Hypothesis: Turkey Application

    Directory of Open Access Journals (Sweden)

    İsmail KÜÇÜKAKSOY

    2015-12-01

    Full Text Available This paper aims to investigate validity of “Export-led Growth Hypothesis” for Turkey using quarterly data in period from 2003:Q1 to 2015:Q1. Hypothesis argues that there is causality relationship from real export to real Gross Domestic Product (GDP. Johansen cointegration test, Gregory-Hansen cointegration test, Toda-Yamamoto causality test, Fully Modified Ordinary Least Squares (FMOLS, Canonical cointegrating regression (CCR and Dynamic ordinary least squares (DOLS methods were used in this study. Findings can be summarized as follows: a According to Johansen cointegration test there is no relationship among variables in the long-run whereas Gregory-Hansen cointegration test has determined relationship in the long-run; b According to Toda-Yamamoto causality test there is bidirectional causality between real export and real GDP. This finding proves the validity of “Export-led Growth Hypothesis” for Turkey; c According to FMOLS, CCR, DOLS methods a 1% increase in the real export increases the real GDP by 1.5195%, 1.5552%, 1.3171% respectively in the long-run. These methods prove the validity of “Export-led Growth Hypothesis” for Turkey.

  5. Human infections and detection of Plasmodium knowlesi.

    Science.gov (United States)

    Singh, Balbir; Daneshvar, Cyrus

    2013-04-01

    Plasmodium knowlesi is a malaria parasite that is found in nature in long-tailed and pig-tailed macaques. Naturally acquired human infections were thought to be extremely rare until a large focus of human infections was reported in 2004 in Sarawak, Malaysian Borneo. Human infections have since been described throughout Southeast Asia, and P. knowlesi is now recognized as the fifth species of Plasmodium causing malaria in humans. The molecular, entomological, and epidemiological data indicate that human infections with P. knowlesi are not newly emergent and that knowlesi malaria is primarily a zoonosis. Human infections were undiagnosed until molecular detection methods that could distinguish P. knowlesi from the morphologically similar human malaria parasite P. malariae became available. P. knowlesi infections cause a spectrum of disease and are potentially fatal, but if detected early enough, infections in humans are readily treatable. In this review on knowlesi malaria, we describe the early studies on P. knowlesi and focus on the epidemiology, diagnosis, clinical aspects, and treatment of knowlesi malaria. We also discuss the gaps in our knowledge and the challenges that lie ahead in studying the epidemiology and pathogenesis of knowlesi malaria and in the prevention and control of this zoonotic infection.

  6. Plasmodium vivax malaria during pregnancy, Bolivia.

    Science.gov (United States)

    Brutus, Laurent; Santalla, José; Schneider, Dominique; Avila, Juan Carlos; Deloron, Philippe

    2013-10-01

    Plasmodium vivax is a major cause of illness in areas with low transmission of malaria in Latin America, Asia, and the Horn of Africa. However, pregnancy-associated malaria remains poorly characterized in such areas. Using a hospital-based survey of women giving birth and an antenatal survey, we assessed the prevalence rates of Plasmodium spp. infections in pregnant women in Bolivia, and evaluated the consequences of malaria during pregnancy on the health of mothers and newborns. P. vivax infection was detected in 7.9% of pregnant women attending antenatal visits, and placental infection occurred in 2.8% of deliveries; these rates did not vary with parity. Forty-two percent of all P. vivax malaria episodes were symptomatic. P. vivax-infected pregnant women were frequently anemic (6.5%) and delivered babies of reduced birthweight. P. vivax infections during pregnancy are clearly associated with serious adverse outcomes and should be considered in prevention strategies of pregnancy-associated malaria.

  7. Severe Plasmodium knowlesi with dengue coinfection.

    Science.gov (United States)

    Che Rahim, Mohd Jazman; Mohammad, Nurashikin; Besari, Alwi Muhd; Wan Ghazali, Wan Syamimee

    2017-02-20

    We report a case of severe Plasmodium knowlesi and dengue coinfection in a previously healthy 59-year-old Malay man who presented with worsening shortness of breath, high-grade fever with chills and rigors, dry cough, myalgia, arthralgia, chest discomfort and poor appetite of 1 week duration. There was a history mosquito fogging around his neighbourhood in his hometown. Further history revealed that he went to a forest in Jeli (northern part of Kelantan) 3 weeks prior to the event. Initially he was treated as severe dengue with plasma leakage complicated with type 1 respiratory failure as evidenced by positive serum NS1-antigen and thrombocytopenia. Blood for malarial parasite (BFMP) was sent for test as there was suspicion of malaria due to persistent thrombocytopenia despite recovering from dengue infection and the presence of a risk factor. The test revealed high count of malaria parasite. Confirmatory PCR identified the parasite to be Plasmodium knowlesi Intravenous artesunate was administered to the patient immediately after acquiring the BFMP result. Severe malaria was complicated with acute kidney injury and septicaemic shock. Fortunately the patient made full recovery and was discharged from the ward after 2 weeks of hospitalisation. 2017 BMJ Publishing Group Ltd.

  8. RETINAL HAEMORRHAGE IN PLASMODIUM VIVAX PATIENTS- 2 RARE CASE REPORTS

    Directory of Open Access Journals (Sweden)

    Sangeeta

    2012-12-01

    Full Text Available ABSTRACT: Retinal haemorrhage is commonly detected during opht halmoscopic examination of patients with Plasmodium falciparum infections. Ho wever, it is observed very rarely in Plasmodium vivax infections. Only six cases of reti nal haemorrhage have been reported so far in Plasmodium vivax infections. We review the literatu re and discuss two such cases of retinal haemorrhage that presented at our hospital. It is sug gested that retinal haemorrhage be routinely ruled out in all malaria patients, and Pla smodium vivax infection be considered in patients with unexplained retinal haemorrhage and fev er.

  9. 78 FR 21349 - Orders Granting Authority To Import and Export Natural Gas, To Export Liquefied Natural Gas, To...

    Science.gov (United States)

    2013-04-10

    ... Granting Authority To Import and Export Natural Gas, To Export Liquefied Natural Gas, To Export Compressed Natural Gas, Vacating Prior Authority and Denying Request for Rehearing During January 2013 ] FE Docket... January 2013, it issued orders granting authority to import and export natural gas and liquefied......

  10. 78 FR 53739 - Orders Granting Authority To Import and Export Natural Gas, To Import and Export Liquefied...

    Science.gov (United States)

    2013-08-30

    ... Granting Authority To Import and Export Natural Gas, To Import and Export Liquefied Natural Gas and... export natural gas, to import and export liquefied natural gas and to vacate prior authority. These... ENERGY) 13-83-LNG STANDARD NATURAL GAS, INC.) 13-81-LNG CASTLETON COMMODITIES CANADA LP) 1...

  11. 78 FR 65304 - Orders Granting Authority To Import and Export Natural Gas, and To Import and Export Liquefied...

    Science.gov (United States)

    2013-10-31

    ... Granting Authority To Import and Export Natural Gas, and To Import and Export Liquefied Natural Gas During... issued orders granting authority to import and export natural gas, and to import and export liquefied natural gas. These orders are summarized in the attached appendix and may be found on the FE Web site...

  12. 78 FR 44940 - Orders Granting Authority To Import and Export Natural Gas, and To Import and Export Liquefied...

    Science.gov (United States)

    2013-07-25

    ... Granting Authority To Import and Export Natural Gas, and To Import and Export Liquefied Natural Gas During May 2013 FE DOCKET NOS. CASCADE NATURAL GAS CORPORATION........ 12-179-NG CASCADE NATURAL GAS... orders granting authority to import and export natural gas and to import and export liquefied......

  13. 22 CFR 123.22 - Filing, retention, and return of export licenses and filing of export information.

    Science.gov (United States)

    2010-04-01

    ...), the DDTC registered exporter will retain the license or other approval and provide the export... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Filing, retention, and return of export licenses and filing of export information. 123.22 Section 123.22 Foreign Relations DEPARTMENT OF...

  14. Chinese Textile Industry Still Taking Advantage on Export ( Part B )

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Diversified export marketsWith China’s textile export markets -- particularlythose in the US -- being strongly affected by the adverseeffects of the ongoing global financial crisis, diversifyingexport markets has become the motto of China’stextile foreign trade policy, a safe way to provide newopportunities to Chinese exporters. In 2008, Chinesetextile exported to 226 countries and regions, of which,38 countries and regions achieved export value of over 1

  15. Learning by Exporting: Does It Matter Where One Learns?

    OpenAIRE

    Natalia Trofimenko

    2005-01-01

    Learning-by-exporting proponents argue that exporting increases productivity by exposing producers to new technologies or through product quality upgrading. This study is based on the observation that the technological superiority and severity of product quality requirements are not the same in all export markets. If learning occurs through the acquisition of new knowledge, exporting to less developed markets should not generate as much productivity growth as exporting to advanced countries. ...

  16. Export intensity behaviour and its determinants for Turkish manufacturing firms

    OpenAIRE

    Günaydın, Burak; Gunaydin, Burak

    2013-01-01

    This paper examines export market entry behavior and export intensity of Turkish manufacturing firms. It tries to explain what kind of firm characteristics, domestic constraints, market properties or regional conditions affect export or do not export decision and export intensity levels of firms. Size and productivity, informal competitors in sector, industrial and regional properties are found influential in both decisions. Age, number of competitors in the market, customs regulations and cr...

  17. Structural Changes in Asparagus Production and Exports from Peru

    OpenAIRE

    Shimizu, Tatsuya

    2009-01-01

    Asparagus is the star product among non-traditional agricultural exports (NTAXs) in Peru. The export of preserved asparagus has expanded since the end of the 1980s. Although there was some stagnation in the mid-1990s, exports of fresh asparagus have expanded rapidly since the end of the 1990s. Now, the export of both preserved and fresh asparagus constitute the second most important agricultural export in Peru after coffee. Besides the change in demand on the international market, the importa...

  18. Arrest of Nuclear Division in Plasmodium through Blockage of Erythrocyte Surface Exposed Ribosomal Protein P2

    Science.gov (United States)

    Das, Sudipta; Basu, Himanish; Korde, Reshma; Tewari, Rita; Sharma, Shobhona

    2012-01-01

    Malaria parasites reside inside erythrocytes and the disease manifestations are linked to the growth inside infected erythrocytes (IE). The growth of the parasite is mostly confined to the trophozoite stage during which nuclear division occurs followed by the formation of cell bodies (schizogony). The mechanism and regulation of schizogony are poorly understood. Here we show a novel role for a Plasmodium falciparum 60S stalk ribosomal acidic protein P2 (PfP2) (PFC0400w), which gets exported to the IE surface for 6–8 hrs during early schizogony, starting around 26–28 hrs post-merozoite invasion. The surface exposure is demonstrated using multiple PfP2-specific monoclonal antibodies, and is confirmed through transfection using PfP2-GFP. The IE surface-exposed PfP2-protein occurs mainly as SDS-resistant P2-homo-tetramers. Treatment with anti-PfP2 monoclonals causes arrest of IEs at the first nuclear division. Upon removal of the antibodies, about 80–85% of synchronized parasites can be released even after 24 hrs of antibody treatment. It has been reported that a tubovesicular network (TVN) is set up in early trophozoites which is used for nutrient import. Anti-P2 monoclonal antibodies cause a complete fragmentation of TVN by 36 hrs, and impairs lipid import in IEs. These may be downstream causes for the cell-cycle arrest. Upon antibody removal, the TVN is reconstituted, and the cell division progresses. Each of the above properties is observed in the rodent malaria parasite species P. yoelii and P. berghei. The translocation of the P2 protein to the IE surface is therefore likely to be of fundamental importance in Plasmodium cell division. PMID:22912579

  19. Cationic surfactant-based colorimetric detection of Plasmodium lactate dehydrogenase, a biomarker for malaria, using the specific DNA aptamer.

    Directory of Open Access Journals (Sweden)

    Seonghwan Lee

    Full Text Available A simple, sensitive, and selective colorimetric biosensor for the detection of the malarial biomarkers Plasmodium vivax lactate dehydrogenase (PvLDH and Plasmodium falciparum LDH (PfLDH was demonstrated using the pL1 aptamer as the recognition element and gold nanoparticles (AuNPs as probes. The proposed method is based on the aggregation of AuNPs using hexadecyltrimethylammonium bromide (CTAB. The AuNPs exhibited a sensitive color change from red to blue, which could be seen directly with the naked eye and was monitored using UV-visible absorption spectroscopy and transmission electron microscopy (TEM. The reaction conditions were optimized to obtain the maximum color intensity. PvLDH and PfLDH were discernible with a detection limit of 1.25 pM and 2.94 pM, respectively. The applicability of the proposed biosensor was also examined in commercially available human serum.

  20. Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice

    Science.gov (United States)

    Soulard, Valérie; Bosson-Vanga, Henriette; Lorthiois, Audrey; Roucher, Clémentine; Franetich, Jean- François; Zanghi, Gigliola; Bordessoulles, Mallaury; Tefit, Maurel; Thellier, Marc; Morosan, Serban; Le Naour, Gilles; Capron, Frédérique; Suemizu, Hiroshi; Snounou, Georges; Moreno-Sabater, Alicia; Mazier, Dominique

    2015-01-01

    Experimental studies of Plasmodium parasites that infect humans are restricted by their host specificity. Humanized mice offer a means to overcome this and further provide the opportunity to observe the parasites in vivo. Here we improve on previous protocols to achieve efficient double engraftment of TK-NOG mice by human primary hepatocytes and red blood cells. Thus, we obtain the complete hepatic development of P. falciparum, the transition to the erythrocytic stages, their subsequent multiplication, and the appearance of mature gametocytes over an extended period of observation. Furthermore, using sporozoites derived from two P. ovale-infected patients, we show that human hepatocytes engrafted in TK-NOG mice sustain maturation of the liver stages, and the presence of late-developing schizonts indicate the eventual activation of quiescent parasites. Thus, TK-NOG mice are highly suited for in vivo observations on the Plasmodium species of humans. PMID:26205537

  1. Plasmodium vivax and Plasmodium falciparum are Common Malaria Species in Pakistan

    Directory of Open Access Journals (Sweden)

    Tauseef Ahmad

    2016-06-01

    Full Text Available The microbes have a diverse nature, it makes human laugh and cry. Some microbes are fruitful for humans while others are harmful. Infectious diseases are a key problem in the modern world. In the last few decades, million of peoples have died from different diseases, including bacterial, viral, fungal, parasitic, etc. Among these diseases, malaria is one of the major health problems for developing countries including Pakistan. This study was undertaken to provide baseline information about the prevalence of malaria, species distribution and to contribute to the data regarding epidemiology in Pakistan. For a collection of literature, the electronic search engine was used, using different key words i.e. prevalence, species distribution, epidemiology of malaria in Pakistan, etc. The time frame of the obtained articles was from 2000 to 2014. The two species of malaria Plasmodium vivax and Plasmodium falciparum are common in Pakistan. [Biomed Res Ther 2016; 3(6.000: 666-672

  2. A Study on the Importance of Export Assistance Programs: The case of Exporting Small and Medium Sized Enterprises of Malaysia

    OpenAIRE

    Sa’ari Ahmad; Mohammed S. Chowdhury

    2012-01-01

    The empirical study presented in this report focused on government export incentives for small and medium-sized enterprises (SMEs) that involved in exporting. More specifically, the study attempted to examine the significance of exporting incentives to the exporting activities of the Malaysian SMEs. The data for the study was collected through the mail of 2000 questionnaires to the selected exporting SMEs. Two hundred firms responded by returning the questionnaires. Only 154 questionnaires we...

  3. CONCENTRATION OF WORLD EXPORTS OF FOREST PRODUCTS

    Directory of Open Access Journals (Sweden)

    Luiz Moreira Coelho Junior

    2013-12-01

    Full Text Available http://dx.doi.org/10.5902/1980509812353This study analyzed the degree of concentration in worldwide exports of forest products in the period rangingfrom 1961 to 2008. The data used are available at the United Nations Food and Agriculture Organization(FAO. The concentration was determined by the concentration ratio [HR (k], the Herfindahl-HirschmanIndex (HHI, Theil Entropy Index (E and the Gini index (G. The main conclusions were: The aggregateBrazilian share in the world exports of forest products is increasing over time; the most important sectors inthe aggregate world exports of forest products, in decreasing order, were pulp, lumber, paper and cardboard,wooden panels, saw and fire wood. According to Bain, the concentration ratio of the four and eight largestexporters of forest products is moderately low; the HHI and Theil Entropy (E show a reduction in theconcentration of world exports of forest products and greater competition among the countries that sell suchproducts; the Gini index indicates that despite the increase in export of forest products over the period ofanalysis, a smaller number of competitors concentrate increasingly larger shares of international exports of these products; summary indices (HHI, E and G indicated that increased competition has not led to a moreequitable distribution of forest products so as to bring down inequalities and concentration of profits in thesector; despite the downward trend in CR (4 and CR (8, there is an increase in G, probably because theeconomies of scale in the international trade have been held by few competitors; caution is recommendedin the analysis of summary indices (HHI, E and G which had better be checked jointly with the partialindices [CR (k] in order to avoid wrong conclusions; countries with a significant share in total exports, suchas Brazil, should seek business strategies to retain competitive advantages, especially those arising fromeconomies of scale.

  4. Hydrological controls on glacially exported microbial assemblages

    Science.gov (United States)

    Dubnick, Ashley; Kazemi, Sina; Sharp, Martin; Wadham, Jemma; Hawkings, Jon; Beaton, Alexander; Lanoil, Brian

    2017-05-01

    The Greenland Ice Sheet (GrIS) exports approximately 400 km3 of freshwater annually to downstream freshwater and marine ecosystems. These meltwaters originate in a wide range of well-defined habitats that can be associated with very different physical environments within the ice sheet, ranging from oxygenated surface environments that are exposed to light and supplied with nutrients from atmospheric/aeolian sources to subglacial environments that are permanently dark, isolated from the atmosphere, and potentially anoxic. Hydrological conditions in the latter likely favor prolonged rock-water contact. The seasonally evolving hydrological system that drains meltwaters from the GrIS connects these distinct microbial habitats and exports the microbes contained within them to downstream ecosystems. The microbial assemblages exported in glacier meltwater may have an impact on downstream ecosystem function and development. We explored how the seasonal development of a glacial drainage system influences the character of microbial assemblages exported from the GrIS by monitoring the seasonal changes in hydrology, water chemistry, and microbial assemblage composition of meltwaters draining from a glacier in southwest Greenland. We found that the microbial assemblages exported in meltwaters varied in response to glacier hydrological flow path characteristics. Whether or not meltwaters passed through the subglacial environment was the first-order control on the composition of the microbial assemblages exported from the glacier, while water source (i.e., supraglacial or extraglacial) and subglacial residence times were second-order controls. Glacier hydrology therefore plays a fundamental role in determining the microbial exports from glaciated watersheds.

  5. The ETRAMP family member SEP2 is expressed throughout Plasmodium berghei life cycle and is released during sporozoite gliding motility.

    Directory of Open Access Journals (Sweden)

    Chiara Currà

    Full Text Available The early transcribed membrane proteins ETRAMPs belong to a family of small, transmembrane molecules unique to Plasmodium parasite, which share a signal peptide followed by a short lysine-rich stretch, a transmembrane domain and a variable, highly charged C-terminal region. ETRAMPs are usually expressed in a stage-specific manner. In the blood stages they localize to the parasitophorous vacuole membrane and, in described cases, to vesicle-like structures exported to the host erythrocyte cytosol. Two family members of the rodent parasite Plasmodium berghei, uis3 and uis4, localize to secretory organelles of sporozoites and to the parasitophorous membrane vacuole of the liver stages. By the use of specific antibodies and the generation of transgenic lines, we showed that the P. berghei ETRAMP family member SEP2 is abundantly expressed in gametocytes as well as in mosquito and liver stages. In intracellular parasite stages, SEP2 is routed to the parasitophorous vacuole membrane while, in invasive ookinete and sporozoite stages, it localizes to the parasite surface. To date SEP2 is the only ETRAMP protein detected throughout the parasite life cycle. Furthermore, SEP2 is also released during gliding motility of salivary gland sporozoites. A limited number of proteins are known to be involved in this key function and the best characterized, the CSP and TRAP, are both promising transmission-blocking candidates. Our results suggest that ETRAMP members may be viewed as new potential candidates for malaria control.

  6. Veterinary export certification: potential barriers to Dutch exports in world markets

    NARCIS (Netherlands)

    Achterbosch, T.J.; Rau, M.L.

    2010-01-01

    The official veterinary export certificate is a comprehensive instrument to regulate risks of animal disease transmission in global food trade. This paper documents how veterinary health attestation by public veterinary service in the Netherlands prevents export impediments. In order to maintain the

  7. 78 FR 12719 - President's Export Council: Meeting of the President's Export Council

    Science.gov (United States)

    2013-02-25

    ... services agreement, bilateral investment treaties, U.S.- Canada trade facilitation, the UNIDROIT Cape Town... International Trade Administration President's Export Council: Meeting of the President's Export Council AGENCY: International Trade Administration, U.S. Department of Commerce. ACTION: Notice of an Open Meeting. SUMMARY: The...

  8. Export diversification in Uganda : developments in non-traditional agricultural exports

    NARCIS (Netherlands)

    Dijkstra, Tjalling

    2001-01-01

    Over the last two decades agricultural export diversification has been pushed as an economic development strategy for sub-Saharan Africa. This paper looks at Uganda, where nontraditional agricultural export commodities have been (re)-introduced since Museveni came to power in 1986. The most importan

  9. 77 FR 42973 - Export and Reexport Controls to Rwanda and United Nations Sanctions Under the Export...

    Science.gov (United States)

    2012-07-23

    ... Controls to Rwanda and United Nations Sanctions Under the Export Administration Regulations AGENCY: Bureau... Industry and Security (BIS) amends the Export Administration Regulations (EAR) to implement United Nations... conforming changes in the EAR related to the termination of the United Nations embargo on ``arms and...

  10. Veterinary export certification: potential barriers to Dutch exports in world markets

    NARCIS (Netherlands)

    Achterbosch, T.J.; Rau, M.L.

    2010-01-01

    The official veterinary export certificate is a comprehensive instrument to regulate risks of animal disease transmission in global food trade. This paper documents how veterinary health attestation by public veterinary service in the Netherlands prevents export impediments. In order to maintain the

  11. RNA-guided assembly of Rev-RRE nuclear export complexes.

    Science.gov (United States)

    Bai, Yun; Tambe, Akshay; Zhou, Kaihong; Doudna, Jennifer A

    2014-08-27

    HIV replication requires nuclear export of unspliced and singly spliced viral transcripts. Although a unique RNA structure has been proposed for the Rev-response element (RRE) responsible for viral mRNA export, how it recruits multiple HIV Rev proteins to form an export complex has been unclear. We show here that initial binding of Rev to the RRE triggers RNA tertiary structural changes, enabling further Rev binding and the rapid formation of a viral export complex. Analysis of the Rev-RRE assembly pathway using SHAPE-Seq and small-angle X-ray scattering (SAXS) reveals two major steps of Rev-RRE complex formation, beginning with rapid Rev binding to a pre-organized region presenting multiple Rev binding sites. This step induces long-range remodeling of the RNA to expose a cryptic Rev binding site, enabling rapid assembly of additional Rev proteins into the RNA export complex. This kinetic pathway may help maintain the balance between viral replication and maturation.DOI: http://dx.doi.org/10.7554/eLife.03656.001.

  12. Immunization of mice with Plasmodium TCTP delays establishment of Plasmodium infection.

    Science.gov (United States)

    Taylor, K J; Van, T T H; MacDonald, S M; Meshnick, S R; Fernley, R T; Macreadie, I G; Smooker, P M

    2015-01-01

    Translationally controlled tumour protein (TCTP) may play an important role in the establishment or maintenance of parasitemia in a malarial infection. In this study, the potential of TCTP as a malaria vaccine was investigated in two trials. In the initial vaccine trial, Plasmodium falciparum TCTP (PfTCTP) was expressed in Saccharomyces cerevisiae and used to immunize BALB/c mice. Following challenge with Plasmodium yoelii YM, parasitemia was significantly reduced during the early stages of infection. In the second vaccine trial, the TCTP from P. yoelii and P. berghei was expressed in Escherichia coli and used in several mouse malaria models. A significant reduction in parasitemia in the early stages of infection was observed in BALB/c mice challenged with P. yoelii YM. A significantly reduced parasitemia at each day leading up to a delayed and reduced peak parasitemia was also observed in BALB/c mice challenged with the nonlethal Plasmodium chabaudi (P.c.) chabaudi AS. These results suggest that TCTP has an important role for parasite establishment and may be important for pathogenesis. © 2014 John Wiley & Sons Ltd.

  13. STUDY ON RELATIVE ABUNDANCE OF Plasmodium SPECIES: A ...

    African Journals Online (AJOL)

    DR. AMINU

    2013-06-01

    Jun 1, 2013 ... Keywords: abundance, plasmodium, relative, thin blood film, malaria control programmes. INTRODUCTION ... When an infected female Anopheles mosquito bites a ... the understanding of the type of infection as well as.

  14. Plasmodium infection in a Leadbeater's possum (Gymnobelideus leadbeateri).

    Science.gov (United States)

    Scheelings, T F; McLaren, P J; Tatarczuch, L; Slocombe, R F

    2016-08-01

    A wild-caught, adult female Leadbeater's possum (Gymnobelideus leadbeateri) died while in captivity after suffering from chronic ill-thrift that progressed to acute respiratory distress. On histopathological examination of tissues, the cause of death was determined to be severe acute pneumonia with pulmonary oedema associated with an intracellular protozoan parasite present within erythrocytes. Transmission electron microscopy was performed on lung tissues and organisms consistent for Plasmodium sp. were identified within numerous erythrocytes. Molecular characterisation of the parasite from DNA extracted from tissue blocks of fixed lung determined the organism to belong to the genus Plasmodium (100% similarity to Plasmodium species when a BLAST analysis was performed); however, speciation of the organism was not possible. This is the first report of Plasmodium sp. infection and subsequent disease in a native Australian mammal. The lifecycle of this parasite remains unknown. It is also unknown what effects haemoparasitism may have on the population dynamics of this endangered possum species. © 2016 Australian Veterinary Association.

  15. International population movements and regional Plasmodium falciparum malaria elimination strategies

    National Research Council Canada - National Science Library

    Andrew J. Tatem; David L. Smith; Susan Hanson

    2010-01-01

    ... to areas targeted for elimination. Here, census-based migration data were analyzed with network analysis tools, Plasmodium falciparum malaria transmission maps, and global population databases to map globally communities of countries...

  16. Peripheral blood cell signatures of Plasmodium falciparum infection during pregnancy

    DEFF Research Database (Denmark)

    Ibitokou, Samad; Oesterholt, Mayke; Brutus, Laurent;

    2012-01-01

    Sequestration of Plasmodium falciparum-infected erythrocytes in placental intervillous spaces causes inflammation and pathology. Knowledge of the profiles of immune cells associated with the physiopathology of pregnancy-associated malaria (PAM) is scarce. We conducted a longitudinal, prospective...

  17. Heterologous Protection against Malaria after Immunization with Plasmodium falciparum Sporozoites

    NARCIS (Netherlands)

    Schats, R.; Bijker, E.M.; Gemert, G.J.A. van; Graumans, W.; Vegte-Bolmer, M. van de; Lieshout, L. van; Haks, M.C.; Hermsen, C.C.; Scholzen, A.; Visser, L.G.; Sauerwein, R.W.

    2015-01-01

    BACKGROUND: Sterile protection in >90% of volunteers against homologous Plasmodium falciparum infection has been achieved only using the controlled human malaria infection (CHMI) model. This efficient model involves whole parasite immunizations under chloroquine prophylaxis (CPS-immunization),

  18. Guillain-Barré syndrome in Plasmodium falciparum malaria.

    OpenAIRE

    Wijesundere, A.

    1992-01-01

    A patient with Plasmodium falciparum malaria developed peripheral neuropathy. Clinical, cerebro-spinal fluid examination and nerve conduction studies confirmed Guillain-Barré syndrome, not previously reported in P. falciparum malaria.

  19. On the Relationship between Tropical Moisture Exports and Extratropical Cyclones

    Science.gov (United States)

    Knippertz, Peter; Wernli, Heini; Gläser, Gregor; Boleti, Eirini; Joos, Hanna; Binder, Hanin

    2016-04-01

    Tropical moisture export (TME) events are an important element of the global circulation and contribute significantly to regional precipitation. They are defined here on the basis of trajectories starting in the tropical troposphere and reaching a water vapor flux of at least 100 g kg-1 m s-1 poleward of 35° latitude. TME frequency shows four marked occurrence maxima in both hemispheres with varying seasonal cycles. In some cases TMEs can be linked to similar phenomena of atmospheric flow such as Warm Conveyor Belts (WCBs) or Atmospheric Rivers (ARs). For example, 90% of all ARs affecting the US West Coast during December-May are connected to TME events, but the tropical moisture source is less important during the more active AR season June-November. In addition to these climatological TME characteristics we discuss two aspects of their relationship to extratropical cyclones: Case studies indicate that (i) cyclones traveling along the southern fringes of the midlatitude storm track can instigate the export of tropical moisture ahead of their cold fronts, and (ii) the tropical moisture can fuel latent heat release in the cyclone and therefore contribute to its intensification. A long-term statistical analysis of passages of TME trajectories through areas with closed isobars surrounding active cyclones in the northern hemisphere reveals a surprisingly small number of encounters, particularly in winter. The majority of hits occur south of 40°N and there is no statistically significant relationship with cyclone intensification. The results suggest that TMEs often pass relatively far from cyclone centers where vertical motions tend to be moderate. This prevents an early rainout of the tropical moisture and allows the export into higher latitudes. For the same reasons we expect TMEs to "avoid" WCBs with roots at low latitudes. This interpretation is consistent with the fact that most TME maxima are located along the western flanks of subtropical high-pressure systems.

  20. Anti-Plasmodium activity of ceramide analogs

    Directory of Open Access Journals (Sweden)

    Gatt Shimon

    2004-12-01

    Full Text Available Abstract Background Sphingolipids are key molecules regulating many essential functions in eukaryotic cells and ceramide plays a central role in sphingolipid metabolism. A sphingolipid metabolism occurs in the intraerythrocytic stages of Plasmodium falciparum and is associated with essential biological processes. It constitutes an attractive and potential target for the development of new antimalarial drugs. Methods The anti-Plasmodium activity of a series of ceramide analogs containing different linkages (amide, methylene or thiourea linkages between the fatty acid part of ceramide and the sphingoid core was investigated in culture and compared to the sphingolipid analog PPMP (d,1-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol. This analog is known to inhibit the parasite sphingomyelin synthase activity and block parasite development by preventing the formation of the tubovesicular network that extends from the parasitophorous vacuole to the red cell membrane and delivers essential extracellular nutrients to the parasite. Results Analogs containing methylene linkage showed a considerably higher anti-Plasmodium activity (IC50 in the low nanomolar range than PPMP and their counterparts with a natural amide linkage (IC50 in the micromolar range. The methylene analogs blocked irreversibly P. falciparum development leading to parasite eradication in contrast to PPMP whose effect is cytostatic. A high sensitivity of action towards the parasite was observed when compared to their effect on the human MRC-5 cell growth. The toxicity towards parasites did not correlate with the inhibition by methylene analogs of the parasite sphingomyelin synthase activity and the tubovesicular network formation, indicating that this enzyme is not their primary target. Conclusions It has been shown that ceramide analogs were potent inhibitors of P. falciparum growth in culture. Interestingly, the nature of the linkage between the fatty acid part and the

  1. Placental histopathological changes associated with Plasmodium vivax infection during pregnancy.

    Directory of Open Access Journals (Sweden)

    Rodrigo M Souza

    Full Text Available Histological evidence of Plasmodium in the placenta is indicative of placental malaria, a condition associated with severe outcomes for mother and child. Histological lesions found in placentas from Plasmodium-exposed women include syncytial knotting, syncytial rupture, thickening of the placental barrier, necrosis of villous tissue and intervillositis. These histological changes have been associated with P. falciparum infections, but little is known about the contribution of P. vivax to such changes. We conducted a cross-sectional study with pregnant women at delivery and assigned them to three groups according to their Plasmodium exposure during pregnancy: no Plasmodium exposure (n = 41, P. vivax exposure (n = 59 or P. falciparum exposure (n = 19. We evaluated their placentas for signs of Plasmodium and placental lesions using ten histological parameters: syncytial knotting, syncytial rupture, placental barrier thickness, villi necrosis, intervillous space area, intervillous leucocytes, intervillous mononucleates, intervillous polymorphonucleates, parasitized erythrocytes and hemozoin. Placentas from P. vivax-exposed women showed little evidence of Plasmodium or hemozoin but still exhibited more lesions than placentas from women not exposed to Plasmodium, especially when infections occurred twice or more during pregnancy. In the Brazilian state of Acre, where diagnosis and primary treatment are readily available and placental lesions occur in the absence of detected placental parasites, relying on the presence of Plasmodium in the placenta to evaluate Plasmodium-induced placental pathology is not feasible. Multivariate logistic analysis revealed that syncytial knotting (odds ratio [OR], 4.21, P = 0.045, placental barrier thickness (OR, 25.59, P = 0.021 and mononuclear cells (OR, 4.02, P = 0.046 were increased in placentas from P. vivax-exposed women when compared to women not exposed to Plasmodium during pregnancy. A

  2. Limitations of microscopy to differentiate Plasmodium species in a region co-endemic for Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi

    OpenAIRE

    Barber Bridget E; William Timothy; Grigg Matthew J; Yeo Tsin W; Anstey Nicholas M

    2013-01-01

    Abstract Background In areas co-endemic for multiple Plasmodium species, correct diagnosis is crucial for appropriate treatment and surveillance. Species misidentification by microscopy has been reported in areas co-endemic for vivax and falciparum malaria, and may be more frequent in regions where Plasmodium knowlesi also commonly occurs. Methods This prospective study in Sabah, Malaysia, evaluated the accuracy of routine district and referral hospital-based microscopy, and microscopy perfor...

  3. Detecting larval export from marine reserves.

    Science.gov (United States)

    Pelc, R A; Warner, R R; Gaines, S D; Paris, C B

    2010-10-26

    Marine reserve theory suggests that where large, productive populations are protected within no-take marine reserves, fished areas outside reserves will benefit through the spillover of larvae produced in the reserves. However, empirical evidence for larval export has been sparse. Here we use a simple idealized coastline model to estimate the expected magnitude and spatial scale of larval export from no-take marine reserves across a range of reserve sizes and larval dispersal scales. Results suggest that, given the magnitude of increased production typically found in marine reserves, benefits from larval export are nearly always large enough to offset increased mortality outside marine reserves due to displaced fishing effort. However, the proportional increase in recruitment at sites outside reserves is typically small, particularly for species with long-distance (on the order of hundreds of kilometers) larval dispersal distances, making it very difficult to detect in field studies. Enhanced recruitment due to export may be detected by sampling several sites at an appropriate range of distances from reserves or at sites downcurrent of reserves in systems with directional dispersal. A review of existing empirical evidence confirms the model's suggestion that detecting export may be difficult without an exceptionally large differential in production, short-distance larval dispersal relative to reserve size, directional dispersal, or a sampling scheme that encompasses a broad range of distances from the reserves.

  4. Antioxidant defense in Plasmodium falciparum – data mining of the transcriptome

    Directory of Open Access Journals (Sweden)

    Ginsburg Hagai

    2004-07-01

    Full Text Available Abstract The intraerythrocytic malaria parasite is under constant oxidative stress originating both from endogenous and exogenous processes. The parasite is endowed with a complete network of enzymes and proteins that protect it from those threats, but also uses redox activities to regulate enzyme activities. In the present analysis, the transcription of the genes coding for the antioxidant defense elements are viewed in the time-frame of the intraerythrocytic cycle. Time-dependent transcription data were taken from the transcriptome of the human malaria parasite Plasmodium falciparum. Whereas for several processes the transcription of the many participating genes is coordinated, in the present case there are some outstanding deviations where gene products that utilize glutathione or thioredoxin are transcribed before the genes coding for elements that control the levels of those substrates are transcribed. Such insights may hint to novel, non-classical pathways that necessitate further investigations.

  5. Desferrioxamine suppresses Plasmodium falciparum in Aotus monkeys.

    Science.gov (United States)

    Pollack, S; Rossan, R N; Davidson, D E; Escajadillo, A

    1987-02-01

    Clinical observation has suggested that iron deficiency may be protective in malaria, and we have found that desferrioxamine (DF), an iron-specific chelating agent, inhibited Plasmodium falciparum growth in vitro. It was difficult to be confident that DF would be effective in an intact animal, however, because continuous exposure to DF was required in vitro and, in vivo, DF is rapidly excreted. Also, the in vitro effect of DF was overcome by addition of iron to the culture and in vivo there are potentially high local iron concentrations when iron is absorbed from the diet or released from reticuloendothelial cells. We now show that DF given by constant subcutaneous infusion does suppress parasitemia in P. falciparum-infected Aotus monkeys.

  6. Development of vaccines for Plasmodium vivax malaria.

    Science.gov (United States)

    Mueller, Ivo; Shakri, Ahmad Rushdi; Chitnis, Chetan E

    2015-12-22

    Plasmodium vivax continues to cause significant morbidity outside Africa with more than 50% of malaria cases in many parts of South and South-east Asia, Pacific islands, Central and South America being attributed to P. vivax infections. The unique biology of P. vivax, including its ability to form latent hypnozoites that emerge months to years later to cause blood stage infections, early appearance of gametocytes before clinical symptoms are apparent and a shorter development cycle in the vector makes elimination of P. vivax using standard control tools difficult. The availability of an effective vaccine that provides protection and prevents transmission would be a valuable tool in efforts to eliminate P. vivax. Here, we review the latest developments related to P. vivax malaria vaccines and discuss the challenges as well as directions toward the goal of developing highly efficacious vaccines against P. vivax malaria.

  7. Wanted Plasmodium falciparum, dead or alive

    Directory of Open Access Journals (Sweden)

    Fatimata Sow

    2015-07-01

    Full Text Available Mechanisms of cell death in unicellular parasites have been subjects of debate for the last decade, with studies demonstrating evidence of apoptosis or non-apoptosis like mechanisms, including necrosis, and autophagy. Recent clarifications on the definition of regulated or accidental cell death by The Nomenclature Committee on Cell Death provides an opportunity to reanalyze some data, re-evaluate conclusions in the light of parasite diversity, and to propose alternative arguments in the context of malaria drug resistance, considering lack of really new drugs in the pipeline. Deciphering the mechanisms of death may help in detection of new drug targets and the design of innovative drugs. However, classifications have been evolving rapidly since initial description of “programmed cell death”, leading to some uncertainty as to whether Plasmodium cell death is accidental or regulated.

  8. Plasmodium falciparum drug resistance in Angola.

    Science.gov (United States)

    Fançony, Cláudia; Brito, Miguel; Gil, Jose Pedro

    2016-02-09

    Facing chloroquine drug resistance, Angola promptly adopted artemisinin-based combination therapy as the first-line to treat malaria. Currently, the country aims to consolidate malaria control, while preparing for the elimination of the disease, along with others African countries in the region. However, the remarkable capacity of Plasmodium to develop drug resistance represents an alarming threat for those achievements. Herein, the available, but relatively scarce and dispersed, information on malaria drug resistance in Angola, is reviewed and discussed. The review aims to inform but also to encourage future research studies that monitor and update the information on anti-malarial drug efficacy and prevalence of molecular markers of drug resistance, key fields in the context and objectives of elimination.

  9. Gametocytogenesis : the puberty of Plasmodium falciparum

    Directory of Open Access Journals (Sweden)

    Ariey Frédéric

    2004-07-01

    Full Text Available Abstract The protozoan Plasmodium falciparum has a complex life cycle in which asexual multiplication in the vertebrate host alternates with an obligate sexual reproduction in the anopheline mosquito. Apart from the apparent recombination advantages conferred by sex, P. falciparum has evolved a remarkable biology and adaptive phenotypes to insure its transmission despite the dangers of sex. This review mainly focuses on the current knowledge on commitment to sexual development, gametocytogenesis and the evolutionary significance of various aspects of gametocyte biology. It goes further than pure biology to look at the strategies used to improve successful transmission. Although gametocytes are inevitable stages for transmission and provide a potential target to fight malaria, they have received less attention than the pathogenic asexual stages. There is a need for research on gametocytes, which are a fascinating stage, responsible to a large extent for the success of P. falciparum.

  10. Rare earth elements and strategic mineral policy

    NARCIS (Netherlands)

    Kooroshy, J.; Korteweg, R.; Ridder, M. de

    2010-01-01

    Newspapers report almost daily on international tensions around ‘strategic’ or ‘critical’ minerals such as rare earth elements. The temporary freeze of rare earth exports from China to Japan in late 2010 in retaliation of the capture of a Chinese captain is but one example of the strategic use of no

  11. Epidemiology of Plasmodium vivax Malaria in Peru.

    Science.gov (United States)

    Rosas-Aguirre, Angel; Gamboa, Dionicia; Manrique, Paulo; Conn, Jan E; Moreno, Marta; Lescano, Andres G; Sanchez, Juan F; Rodriguez, Hugo; Silva, Hermann; Llanos-Cuentas, Alejandro; Vinetz, Joseph M

    2016-12-28

    Malaria in Peru, dominated by Plasmodium vivax, remains a public health problem. The 1990s saw newly epidemic malaria emerge, primarily in the Loreto Department in the Amazon region, including areas near to Iquitos, the capital city, but sporadic malaria transmission also occurred in the 1990s-2000s in both north-coastal Peru and the gold mining regions of southeastern Peru. Although a Global Fund-supported intervention (PAMAFRO, 2005-2010) was temporally associated with a decrease of malaria transmission, from 2012 to the present, both P. vivax and Plasmodium falciparum malaria cases have rapidly increased. The Peruvian Ministry of Health continues to provide artemesinin-based combination therapy for microscopy-confirmed cases of P. falciparum and chloroquine-primaquine for P. vivax Malaria transmission continues in remote areas nonetheless, where the mobility of humans and parasites facilitates continued reintroduction outside of ongoing surveillance activities, which is critical to address for future malaria control and elimination efforts. Ongoing P. vivax research gaps in Peru include the following: identification of asymptomatic parasitemics, quantification of the contribution of patent and subpatent parasitemics to mosquito transmission, diagnosis of nonparasitemic hypnozoite carriers, and implementation of surveillance for potential emergence of chloroquine- and 8-aminoquinoline-resistant P. vivax Clinical trials of tafenoquine in Peru have been promising, and glucose-6-phosphate dehydrogenase deficiency in the region has not been observed to be a limitation to its use. Larger-scale challenges for P. vivax (and malaria in general) in Peru include logistical difficulties in accessing remote riverine populations, consequences of government policy and poverty trends, and obtaining international funding for malaria control and elimination.

  12. Plasmodium vivax adherence to placental glycosaminoglycans.

    Directory of Open Access Journals (Sweden)

    Kesinee Chotivanich

    Full Text Available BACKGROUND: Plasmodium vivax infections seldom kill directly but do cause indirect mortality by reducing birth weight and causing abortion. Cytoadherence and sequestration in the microvasculature are central to the pathogenesis of severe Plasmodium falciparum malaria, but the contribution of cytoadherence to pathology in other human malarias is less clear. METHODOLOGY: The adherence properties of P. vivax infected red blood cells (PvIRBC were evaluated under static and flow conditions. PRINCIPAL FINDINGS: P. vivax isolates from 33 patients were studied. None adhered to immobilized CD36, ICAM-1, or thrombospondin, putative ligands for P. falciparum vascular cytoadherence, or umbilical vein endothelial cells, but all adhered to immobilized chondroitin sulphate A (CSA and hyaluronic acid (HA, the receptors for adhesion of P. falciparum in the placenta. PvIRBC also adhered to fresh placental cells (N = 5. Pre-incubation with chondroitinase prevented PvIRBC adherence to CSA, and reduced binding to HA, whereas preincubation with hyaluronidase prevented adherence to HA, but did not reduce binding to CSA significantly. Pre-incubation of PvIRBC with soluble CSA and HA reduced binding to the immobilized receptors and prevented placental binding. PvIRBC adhesion was prevented by pre-incubation with trypsin, inhibited by heparin, and reduced by EGTA. Under laminar flow conditions the mean (SD shear stress reducing maximum attachment by 50% was 0.06 (0.02 Pa but, having adhered, the PvIRBC could then resist detachment by stresses up to 5 Pa. At 37 °C adherence began approximately 16 hours after red cell invasion with maximal adherence at 30 hours. At 39 °C adherence began earlier and peaked at 24 hours. SIGNIFICANCE: Adherence of P. vivax-infected erythrocytes to glycosaminoglycans may contribute to the pathogenesis of vivax malaria and lead to intrauterine growth retardation.

  13. Epidemiology of Plasmodium vivax Malaria in Peru

    Science.gov (United States)

    Rosas-Aguirre, Angel; Gamboa, Dionicia; Manrique, Paulo; Conn, Jan E.; Moreno, Marta; Lescano, Andres G.; Sanchez, Juan F.; Rodriguez, Hugo; Silva, Hermann; Llanos-Cuentas, Alejandro; Vinetz, Joseph M.

    2016-01-01

    Malaria in Peru, dominated by Plasmodium vivax, remains a public health problem. The 1990s saw newly epidemic malaria emerge, primarily in the Loreto Department in the Amazon region, including areas near to Iquitos, the capital city, but sporadic malaria transmission also occurred in the 1990s–2000s in both north-coastal Peru and the gold mining regions of southeastern Peru. Although a Global Fund-supported intervention (PAMAFRO, 2005–2010) was temporally associated with a decrease of malaria transmission, from 2012 to the present, both P. vivax and Plasmodium falciparum malaria cases have rapidly increased. The Peruvian Ministry of Health continues to provide artemesinin-based combination therapy for microscopy-confirmed cases of P. falciparum and chloroquine–primaquine for P. vivax. Malaria transmission continues in remote areas nonetheless, where the mobility of humans and parasites facilitates continued reintroduction outside of ongoing surveillance activities, which is critical to address for future malaria control and elimination efforts. Ongoing P. vivax research gaps in Peru include the following: identification of asymptomatic parasitemics, quantification of the contribution of patent and subpatent parasitemics to mosquito transmission, diagnosis of nonparasitemic hypnozoite carriers, and implementation of surveillance for potential emergence of chloroquine- and 8-aminoquinoline-resistant P. vivax. Clinical trials of tafenoquine in Peru have been promising, and glucose-6-phosphate dehydrogenase deficiency in the region has not been observed to be a limitation to its use. Larger-scale challenges for P. vivax (and malaria in general) in Peru include logistical difficulties in accessing remote riverine populations, consequences of government policy and poverty trends, and obtaining international funding for malaria control and elimination. PMID:27799639

  14. Danish Exports and Danish Bilateral Aid

    DEFF Research Database (Denmark)

    Hansen, Henrik; Rand, John

    countries. This Evaluation Study presents an econometric analysis of Danish exports to 144 countries over the period from 1981 to 2010. The analysis is based on the gravity model of bilateral trade; a structural model developed over decades and now the central model in analyses of bilateral trade flows...... and trade policies. The main result of the study is that Danish bilateral aid has a positive and statistically significant impact on Danish exports to the recipient countries. Bilateral development assistance may affect exports through several channels. Three of the main channels are direct aid tying......; increasing recipient income where higher income leads to higher imports, and decreased trade costs, say due to improved information about cultural and administrative customs and practices. Thus, as for preferential trade arrangements, bilateral aid has two potential economic effects; trade creation working...

  15. Markups and Firm-Level Export Status

    DEFF Research Database (Denmark)

    De Loecker, Jan; Warzynski, Frederic

    in empirical industrial organization often rely on the availability of very detailed market-level data with information on prices, quantities sold, characteristics of products and more recently supplemented with consumer-level attributes. Often, both researchers and government agencies cannot rely...... on such detailed data, but still need an assessment of whether changes in the operating environment of firms had an impact on markups and therefore on consumer surplus. In this paper, we derive an estimating equation to estimate markups using standard production plant-level data based on the insight of Hall (1986...... and export behavior using plant-level data. We find that i) markups are estimated significantly higher when controlling for unobserved productivity, ii) exporters charge on average higher markups and iii) firms' markups increase (decrease) upon export entry (exit).We see these findings as a first step...

  16. South Africa - record exports defy market misery

    Energy Technology Data Exchange (ETDEWEB)

    Russell, J.

    1999-03-01

    Dry cargo continues to form the backbone of South Africa`s commodities trades, comprising more than 70% of overall import and export activity. Despite economic stagnation in many global markets and poor prospects for any significant recovery in prices, most of South Africa`s dry bulk ports have experienced sustained tonnage levels in 1998, and are focusing on facility improvements to meet future growth expectation. Coal exports in 1998 increased by 2.8 mt to a record 66.7 mt. The main rise in exports was achieved by Richards Bay Coal Terminal (RBCT) but Durban`s BMA terminal and Portnet`s Dry Bulk Terminal or Richards Bay, and the upgraded Maputo Terminals at Mozambique also handled more trade. Expansion projects at RBCT are also mentioned. 1 fig., 1 tab., 2 photos.

  17. Migrant entrepreneurship, economic activity and export performance

    DEFF Research Database (Denmark)

    Baklanov, Nikita; Rezaei, Shahamak; Vang, Jan

    2014-01-01

    Recent studies on transnational entrepreneurship suggest that migrant entrepreneur plays an increasingly significant role as sources of economic activities and especially export revenue. The literature is, however, biased on the US experience, lacks a comparative perspective between migrants...... and non-migrants and is primarily anecdotal in nature. This paper aims to reduce this gap by mapping the recent changes in the role of migrant entrepreneurs as a source of increased economic activity and export revenue in the Danish context and thereby linking the challenges stemming from...... the transnational entrepreneurship literature to the immigration and internationalisation of entrepreneurship literature. Entrepreneurial economic activity in this paper is proxied by the changing share of self-owned firms across ethic categories. Export revenue is proxied by the number of firms in the different...

  18. Export Products and Services Quality Management

    Directory of Open Access Journals (Sweden)

    Constanta Aurelia Chitiba

    2011-05-01

    Full Text Available Quality became the management imperative in the last time and will continue to be the key to success in the future. We often see the words “quality first”, and demands for quality invade every sphere of activity, from the motor vehicles we drive, to the domestic appliances we use, the food we eat and, of course, the products and services we import and export. Quality represents the goal of every business and it is focused on the customer. Satisfying the requirements of the customer is a dynamic activity: both customers and their needs are changing continuous and the suppliers have to recognize this. When it comes to international trade, no exporting country can afford to compromise on quality. The current global economic climate calls for export marketing and promotion efforts with assurances of superior and consistent quality in products and services, rather associated with lower prices.

  19. Learning by Exporting, Importing or Both?

    DEFF Research Database (Denmark)

    Smeets, Valérie; Warzynski, Frederic

    In this paper, we analyze the relationship between exporting/importing status and firm productivity. We use a rich product-firm-level dataset providing both revenue and quantities of all products for a large panel of Danish manufacturing firms over the period 1998-2005 and link it to another...... dataset describing firms' international trade transactions by product. We use our detailed product level information to compute a firm level deflator and avoid the criticism of biased estimates due to the use of industry level deflator. We find that both importing and exporting behaviours are strongly...... to more distant OECD economies is more strongly associated to productivity than exporting to neighboring or other EU countries, especially when controlling for the price specific effect....

  20. Discordance in drug resistance-associated mutation patterns in marker genes of Plasmodium falciparum and Plasmodium knowlesi during coinfections.

    Science.gov (United States)

    Tyagi, Rupesh K; Das, Manoj K; Singh, Shiv S; Sharma, Yagya D

    2013-05-01

    Human Plasmodium knowlesi infections have been reported from several South-East Asian countries, excluding India, but its drug susceptibility profile in mixed-infection cases remains unknown. The chloroquine resistance transporter (CRT) and dihydrofolate reductase (DHFR) genes of P. knowlesi and other Plasmodium species were sequenced from clinical isolates obtained from malaria patients living in the Andaman and Nicobar Islands, India. The merozoite surface protein-1 and 18S rRNA genes of P. knowlesi were also sequenced from these isolates. Among 445 samples analysed, only 53 of them had P. knowlesi-specific gene sequences. While 3 of the 53 cases (5.66%) had P. knowlesi monoinfection, the rest were coinfected with Plasmodium falciparum (86.79%, n = 46) or Plasmodium vivax (7.55%, n = 4), but none with Plasmodium malariae or Plasmodium ovale. There was discordance in the drug resistance-associated mutations among the coinfecting Plasmodium species. This is because the P. knowlesi isolates contained wild-type sequences, while P. falciparum isolates had mutations in the CRT and DHFR marker genes associated with a higher level of chloroquine and antifolate drug resistance, respectively. The mutation pattern indicates that the same patient, having a mixed infection, may be harbouring the drug-susceptible P. knowlesi parasite and a highly drug-resistant P. falciparum parasite. A larger human population in South-East Asia may be at risk of P. knowlesi infection than reported so far. The different drug susceptibility genotypes of P. knowlesi from its coinfecting Plasmodium species in mixed infections adds a new dimension to the malaria control programme, requiring formulation of an appropriate drug policy.

  1. PLOT3D Export Tool for Tecplot

    Science.gov (United States)

    Alter, Stephen

    2010-01-01

    The PLOT3D export tool for Tecplot solves the problem of modified data being impossible to output for use by another computational science solver. The PLOT3D Exporter add-on enables the use of the most commonly available visualization tools to engineers for output of a standard format. The exportation of PLOT3D data from Tecplot has far reaching effects because it allows for grid and solution manipulation within a graphical user interface (GUI) that is easily customized with macro language-based and user-developed GUIs. The add-on also enables the use of Tecplot as an interpolation tool for solution conversion between different grids of different types. This one add-on enhances the functionality of Tecplot so significantly, it offers the ability to incorporate Tecplot into a general suite of tools for computational science applications as a 3D graphics engine for visualization of all data. Within the PLOT3D Export Add-on are several functions that enhance the operations and effectiveness of the add-on. Unlike Tecplot output functions, the PLOT3D Export Add-on enables the use of the zone selection dialog in Tecplot to choose which zones are to be written by offering three distinct options - output of active, inactive, or all zones (grid blocks). As the user modifies the zones to output with the zone selection dialog, the zones to be written are similarly updated. This enables the use of Tecplot to create multiple configurations of a geometry being analyzed. For example, if an aircraft is loaded with multiple deflections of flaps, by activating and deactivating different zones for a specific flap setting, new specific configurations of that aircraft can be easily generated by only writing out specific zones. Thus, if ten flap settings are loaded into Tecplot, the PLOT3D Export software can output ten different configurations, one for each flap setting.

  2. Plasmodium falciparum Nucleosomes Exhibit Reduced Stability and Lost Sequence Dependent Nucleosome Positioning

    Science.gov (United States)

    Silberhorn, Elisabeth; Schwartz, Uwe; Symelka, Anne; de Koning-Ward, Tania; Längst, Gernot

    2016-01-01

    The packaging and organization of genomic DNA into chromatin represents an additional regulatory layer of gene expression, with specific nucleosome positions that restrict the accessibility of regulatory DNA elements. The mechanisms that position nucleosomes in vivo are thought to depend on the biophysical properties of the histones, sequence patterns, like phased di-nucleotide repeats and the architecture of the histone octamer that folds DNA in 1.65 tight turns. Comparative studies of human and P. falciparum histones reveal that the latter have a strongly reduced ability to recognize internal sequence dependent nucleosome positioning signals. In contrast, the nucleosomes are positioned by AT-repeat sequences flanking nucleosomes in vivo and in vitro. Further, the strong sequence variations in the plasmodium histones, compared to other mammalian histones, do not present adaptations to its AT-rich genome. Human and parasite histones bind with higher affinity to GC-rich DNA and with lower affinity to AT-rich DNA. However, the plasmodium nucleosomes are overall less stable, with increased temperature induced mobility, decreased salt stability of the histones H2A and H2B and considerable reduced binding affinity to GC-rich DNA, as compared with the human nucleosomes. In addition, we show that plasmodium histone octamers form the shortest known nucleosome repeat length (155bp) in vitro and in vivo. Our data suggest that the biochemical properties of the parasite histones are distinct from the typical characteristics of other eukaryotic histones and these properties reflect the increased accessibility of the P. falciparum genome. PMID:28033404

  3. Fixed export cost heterogeneity, trade and welfare

    DEFF Research Database (Denmark)

    Jørgensen, Jan Guldager; Schröder, Philipp J.H.

    2008-01-01

    -country intra-industry trade model where firms are of two different marginal costs types and where fixed export costs are heterogeneous across firms. This model traces many of the stylized facts of international trade. However, we find that with heterogeneous fixed export costs there exists a positive bilateral......Recent literature on the workhorse model of intra-industry trade has explored heterogeneous cost structures at the firm level. These approaches have proven to add realism and predictive power. This paper presents a new and simple heterogeneous-firms specification. We develop a symmetric two...

  4. Danish Wind Power Export and Cost

    DEFF Research Database (Denmark)

    Lund, Henrik; Hvelplund, Frede; Alberg Østergaard, Poul

    In a normal wind year, Danish wind turbines generate the equivalent of approx. 20 percent of the Danish electricity demand. This paper argues that only approx. 1 percent of the wind power production is exported. The rest is used to meet domestic Danish electricity demands. The cost of wind power......, a study made by the Danish think tank CEPOS claimed the opposite, i.e. that most of the Danish wind power has been exported in recent years. However, this claim is based on an incorrect interpretation of statistics and a lack of understanding of how the international electricity markets operate...

  5. Colombia's coal exports

    Energy Technology Data Exchange (ETDEWEB)

    Cantillo, J.; McCloskey, G.

    2004-10-01

    Colombia's Coal Exports gives essential insight into the country's export prospects. It outlines the current structure of the industry and plots its likely development. It places Colombia's aspirations in a context of the Atlantic market and addresses the key questions facing the industry and its investors. The contents are: executive summary; introduction; Colombian economics and politics; coal reserves and mining operations; costs; current mines and mining companies; transportation infrastructure; market; and the future. 39 tabs., 2 maps.

  6. Software exporting: a developing country advantage

    Directory of Open Access Journals (Sweden)

    Hossein Askari

    2003-03-01

    Full Text Available Software exports have the potential to make a significant contribution to the economies of developing countries and to the global IT industry. Developing countries have demonstrated a comparative advantage in this export sector and the global IT industry can benefit from this developing country advantage. Today, IT is high investment, high risk, and high reward and has graduated from being a critical support function to a key partner, sometimes responsible for directing the strategy of an enterprise. Business and technology managers cannot afford to miss the opportunities provided by the comparative advantage of developing countries in the IT arena.

  7. mRNA quality control is bypassed for immediate export of stress-responsive transcripts.

    Science.gov (United States)

    Zander, Gesa; Hackmann, Alexandra; Bender, Lysann; Becker, Daniel; Lingner, Thomas; Salinas, Gabriela; Krebber, Heike

    2016-12-12

    Cells grow well only in a narrow range of physiological conditions. Surviving extreme conditions requires the instantaneous expression of chaperones that help to overcome stressful situations. To ensure the preferential synthesis of these heat-shock proteins, cells inhibit transcription, pre-mRNA processing and nuclear export of non-heat-shock transcripts, while stress-specific mRNAs are exclusively exported and translated. How cells manage the selective retention of regular transcripts and the simultaneous rapid export of heat-shock mRNAs is largely unknown. In Saccharomyces cerevisiae, the shuttling RNA adaptor proteins Npl3, Gbp2, Hrb1 and Nab2 are loaded co-transcriptionally onto growing pre-mRNAs. For nuclear export, they recruit the export-receptor heterodimer Mex67-Mtr2 (TAP-p15 in humans). Here we show that cellular stress induces the dissociation of Mex67 and its adaptor proteins from regular mRNAs to prevent general mRNA export. At the same time, heat-shock mRNAs are rapidly exported in association with Mex67, without the need for adapters. The immediate co-transcriptional loading of Mex67 onto heat-shock mRNAs involves Hsf1, a heat-shock transcription factor that binds to heat-shock-promoter elements in stress-responsive genes. An important difference between the export modes is that adaptor-protein-bound mRNAs undergo quality control, whereas stress-specific transcripts do not. In fact, regular mRNAs are converted into uncontrolled stress-responsive transcripts if expressed under the control of a heat-shock promoter, suggesting that whether an mRNA undergoes quality control is encrypted therein. Under normal conditions, Mex67 adaptor proteins are recruited for RNA surveillance, with only quality-controlled mRNAs allowed to associate with Mex67 and leave the nucleus. Thus, at the cost of error-free mRNA formation, heat-shock mRNAs are exported and translated without delay, allowing cells to survive extreme situations.

  8. Investigation Of Export-Led Growth And Growth-Led Export Hypotheses: A Study On Pakistan Exports To USA, UAE and UK

    Directory of Open Access Journals (Sweden)

    Muhammad Azhar Ikram Ahmad

    2011-12-01

    Full Text Available his article is about investigation of export-led growth and growth-led export hypotheses in case of Pakistan exports to top three exports partners namely: USA, UAE and UK. Time series data over the period of 1975 to 2012 has been used. Augmented dickey- fuller test has been used to check unit root within data. Co-integration among the variables has been explored by employing the Johansen's co integration technique. Granger causality test has been used to investigate nature causality among variables under investigation. Johansen's co-integration test revealed the presence of co-integration among variables. As major portion of Pakistani exports approximately 30 percent is towards the top three exports partners, so the investigation of export-led growth and growth-led export hypotheses in case of Pakistan's exports to USA, UAE and UK can helpful for policy makers to adopt a suitable policy prescriptions which finally could lead to enhancement and improvement of exports relations with USA, UAE, and UK. This research can lead towards understanding about the dependency of exports and economic growth on each other.

  9. Superstar Exporters: An Empirical Investigation of Strategic Interactions in Danish Export Markets

    DEFF Research Database (Denmark)

    Ciliberto, Federico; Jäkel, Ina Charlotte

    , product and destination. We also obtain detailed information on applied, preferential tariff protection from the MAcMap-HS6 database. We find evidence of strong negative competitive effects of entry: in the absence of strategic competitive effects, firms would be 54.3 percentage points more likely...... to export to a given market. Next, we run two counterfactual exercises. We show that failing to account for the strategic interaction among superstar exporters leads to: (i) overstating the probability that firms would start exporting to a market following tariff elimination by 8 percentage points; and, (ii...

  10. Exporting a Canadian parenting education program to the Dominican Republic.

    Science.gov (United States)

    McLennan, John D; Leon, Tina; Haffey, Sue; Barker, Leslie A S

    2009-01-01

    The framework of a Canadian-developed parent education program, Nobody's Perfect, was used in the development of a new parent education program offered to parents attending a child nutrition rehabilitation program in the Dominican Republic. While key teaching elements of the original program were retained (e.g., encouraging active participation, emphasizing facilitation over didactic teaching, using experiential learning), locally relevant content was inserted (e.g., diarrhea prevention and treatment strategies). A Canadian team trained a group of Dominicans to deliver the new program to parents of children recovering from malnutrition. This paper describes the development, implementation, and resulting parenting program from this effort. This 8-week program may find use in other settings. In addition, the experience gained from this exportation endeavor may be useful for others undertaking similar initiatives.

  11. Primate malarias: Diversity, distribution and insights for zoonotic Plasmodium

    Directory of Open Access Journals (Sweden)

    Christina Faust

    2015-12-01

    Full Text Available Protozoans within the genus Plasmodium are well-known as the causative agents of malaria in humans. Numerous Plasmodium species parasites also infect a wide range of non-human primate hosts in tropical and sub-tropical regions worldwide. Studying this diversity can provide critical insight into our understanding of human malarias, as several human malaria species are a result of host switches from non-human primates. Current spillover of a monkey malaria, Plasmodium knowlesi, in Southeast Asia highlights the permeability of species barriers in Plasmodium. Also recently, surveys of apes in Africa uncovered a previously undescribed diversity of Plasmodium in chimpanzees and gorillas. Therefore, we carried out a meta-analysis to quantify the global distribution, host range, and diversity of known non-human primate malaria species. We used published records of Plasmodium parasites found in non-human primates to estimate the total diversity of non-human primate malarias globally. We estimate that at least three undescribed primate malaria species exist in sampled primates, and many more likely exist in unstudied species. The diversity of malaria parasites is especially uncertain in regions of low sampling such as Madagascar, and taxonomic groups such as African Old World Monkeys and gibbons. Presence–absence data of malaria across primates enables us to highlight the close association of forested regions and non-human primate malarias. This distribution potentially reflects a long coevolution of primates, forest-adapted mosquitoes, and malaria parasites. The diversity and distribution of primate malaria are an essential prerequisite to understanding the mechanisms and circumstances that allow Plasmodium to jump species barriers, both in the evolution of malaria parasites and current cases of spillover into humans.

  12. Plasmodium malariae and Plasmodium ovale infections in the China-Myanmar border area.

    Science.gov (United States)

    Li, Peipei; Zhao, Zhenjun; Xing, Hua; Li, Wenli; Zhu, Xiaotong; Cao, Yaming; Yang, Zhaoqing; Sattabongkot, Jetsumon; Yan, Guiyun; Fan, Qi; Cui, Liwang

    2016-11-15

    The Greater Mekong Subregion is aiming to achieve regional malaria elimination by 2030. Though a shift in malaria parasite species predominance by Plasmodium vivax has been recently documented, the transmission of the two minor Plasmodium species, Plasmodium malariae and Plasmodium ovale spp., is poorly characterized in the region. This study aims to determine the prevalence of these minor species in the China-Myanmar border area and their genetic diversity. Epidemiology study was conducted during passive case detection in hospitals and clinics in Myanmar and four counties in China along the China-Myanmar border. Cross-sectional surveys were conducted in villages and camps for internally displaced persons to determine the prevalence of malaria infections. Malaria infections were diagnosed initially by microscopy and later in the laboratory using nested PCR for the SSU rRNA genes. Plasmodium malariae and P. ovale infections were confirmed by sequencing the PCR products. The P. ovale subtypes were determined by sequencing the Pocytb, Pocox1 and Pog3p genes. Parasite populations were evaluated by PCR amplification and sequencing of the MSP-1 genes. Antifolate sensitivity was assessed by sequencing the dhfr-ts and dhps genes from the P. malariae and P. ovale isolates. Analysis of 2701 blood samples collected from the China-Myanmar border by nested PCR targeting the parasite SSU rRNA genes identified 561 malaria cases, including 161 Plasmodium falciparum, 327 P. vivax, 66 P. falciparum/P. vivax mixed infections, 4 P. malariae and 3 P. ovale spp. P. vivax and P. falciparum accounted for >60 and ~30% of all malaria cases, respectively. In comparison, the prevalence of P. malariae and P. ovale spp. was very low and only made up ~1% of all PCR-positive cases. Nevertheless, these two species were often misidentified as P. vivax infections or completely missed by microscopy even among symptomatic patients. Phylogenetic analysis of the SSU rRNA, Pocytb, Pocox1 and Pog3p genes

  13. Anti-relapse activity of mirincamycin in the Plasmodium cynomolgi sporozoite-infected Rhesus monkey model

    OpenAIRE

    Fracisco, Susan; Teja-Isavadharm, Paktiya; Gettayacamin, Montip; Berman, Jonathan; Li, Qigui; Melendez, Victor; Saunders, David; Xie, Lisa; Ohrt, Colin

    2014-01-01

    Background Mirincamycin is a close analog of the drug clindamycin used to treat Plasmodium falciparum blood stages. The clinical need to treat Plasmodium vivax dormant liver stages and prevent relapse with a drug other than primaquine led to the evaluation of mirinicamycin against liver stages in animals. Methods cis-mirinicamycin and trans-mirinicamycin were evaluated as prophylaxis against early liver stages of Plasmodium berghei in mice and as antirelapse hypnozoiticides against Plasmodium...

  14. 19 CFR 159.32 - Date of exportation.

    Science.gov (United States)

    2010-04-01

    ... (CONTINUED) LIQUIDATION OF DUTIES Conversion of Foreign Currency § 159.32 Date of exportation. The date of exportation for currency conversion shall be fixed in accordance with § 152.1(c) of this chapter....

  15. Export Marketing of Slavonian Kulen: the Results of Market Research

    Directory of Open Access Journals (Sweden)

    Damir Kovačić

    2003-09-01

    The results of this research are a scientifically based estimate of the export possibilities for Slavonian kulen, and they provide an information basis for the creation of an export marketing program.

  16. The Export-Import Bank of China

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ Established in 1994and solely owned by the central government, The Export-Im-port Bank of China (China Eximbank) is a state policy bank under the direct leadership of the State Council. Its international credit ratings are compatible with the national sovereign ratings.

  17. The Export-Import Bank of China

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

      Established in 1994and solely owned by the central government, The Export-Im-port Bank of China (China Eximbank) is a state policy bank under the direct leadership of the State Council. Its international credit ratings are compatible with the national sovereign ratings.……

  18. Export Processing Zones and Global Class Formation

    NARCIS (Netherlands)

    Neveling, Patrick

    2015-01-01

    This chapter is concerned with one of the most striking developments in the global political economy of capitalism after the Second World War; the rise of export processing zones and special economic zones. Building on long-term ethnohistorical research on the zones’ global spread from one zone in

  19. DOE/solar export opportunities workshop

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-04-01

    The workshop was conducted to bring together persons from government agencies and the US solar industry to initiate dialogue needed to create and implement programs facilitating the export of US solar technology, hardware, and services. A separate abstract was prepared for 23 individual presentations, all of which will appear in Energy Research abstracts (ERA) and Energy Abstracts for Policy Analysis (EAPA).

  20. Human Capital and Wages in Exporting Firms

    DEFF Research Database (Denmark)

    Munch, Jakob Roland; Rose Skaksen, Jan

    2008-01-01

    This paper studies the link between the education level of workers, export performance and wages. We argue that firms may escape intense competition in international markets by using high skilled workers to differentiate their products. This story is consistent with our empirical results. Using a...