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Sample records for planner scintigraphic imaging

  1. Compton scatter correction for planner scintigraphic imaging

    Energy Technology Data Exchange (ETDEWEB)

    Vaan Steelandt, E; Dobbeleir, A; Vanregemorter, J [Algemeen Ziekenhuis Middelheim, Antwerp (Belgium). Dept. of Nuclear Medicine and Radiotherapy

    1995-12-01

    A major problem in nuclear medicine is the image degradation due to Compton scatter in the patient. Photons emitted by the radioactive tracer scatter in collision with electrons of the surrounding tissue. Due to the resulting loss of energy and change in direction, the scattered photons induce an object dependant background on the images. This results in a degradation of the contrast of warm and cold lesions. Although theoretically interesting, most of the techniques proposed in literature like the use of symmetrical photopeaks can not be implemented on the commonly used gamma camera due to the energy/linearity/sensitivity corrections applied in the detector. A method for a single energy isotope based on existing methods with adjustments towards daily practice and clinical situations is proposed. It is assumed that the scatter image, recorded from photons collected within a scatter window adjacent to the photo peak, is a reasonable close approximation of the true scatter component of the image reconstructed from the photo peak window. A fraction `k` of the image using the scatter window is subtracted from the image recorded in the photo peak window to produce the compensated image. The principal matter of the method is the right value for the factor `k`, which is determined in a mathematical way and confirmed by experiments. To determine `k`, different kinds of scatter media are used and are positioned in different ways in order to simulate a clinical situation. For a secondary energy window from 100 to 124 keV below a photo peak window from 126 to 154 keV, a value of 0.7 is found. This value has been verified using both an antropomorph thyroid phantom and the Rollo contrast phantom.

  2. Scintigraphic imaging of endocrine organs

    International Nuclear Information System (INIS)

    Gross, M.D.; Shapiro, B.; Thrall, J.H.; Freitas, J.E.; Beierwaltes, W.H.

    1984-01-01

    The nuclear medicine approach to the portrayal of endocrine organs is unique; the scintigraphic images provide not only anatomic and localization information, but in many instances allow a quantitative assessment of organ function. The ability to image endocrine glands is based upon the design of radionuclides and radiopharmaceuticals with characteristics to take advantage of many unique and specific biochemical and advantage of many unique and specific biochemical and metabolic functions of these tissues. The recent introduction of new radiopharmaceutical and tracers has provided the consulting endocrinologist with imaging procedures that allow localization and functional characterization not available by other single, noninvasive diagnostic modalities. This review will serve as an update of the available techniques to image and quantitate the function of the endocrine glands using the nuclear medicine approach

  3. The new techniques of scintigraphic imaging

    International Nuclear Information System (INIS)

    Chatal, J.F.

    1990-01-01

    The purpose of scintigraphic imaging is not to explore the morphology of an organ (or its abnormalities) but rather its functional and metabolic characteristics. It is thus important that a molecular structure (e.g., a hormonal receptor or an antigen) closely linked to the functional activity of an organ or tissue be targeted on its cell surface. Such diagnostic targeting requires the synthesis and labeling of a radiopharmaceutical substance specific for the receptor or antigen in question. It also requires a detection system adapted to count rates and signal-to-background ratios (generally moderate). The synthesis of new radiopharmaceutical agents, a critical stage for the future of nuclear medicine, is a long and often risky process in which success is difficult to foresee. Radiolabeling must be stable in vitro and in vivo, and the radiopharmaceutical must subsequently retain its capability of recognizing the targeted molecule. In endocrinology, the exemplary achievement in this direction has been the synthesis of 131 I-6-iodomethylnorcholesterol and 131 I-metaiodobenzylguanidine for functional scintigraphy of the adrenal cortex and medulla. Progress in detection equipment has been marked by the development of monophotonic tomoscintigraphy, using gamma cameras with a revolving head to obtain slices in different spatial planes showing the distribution in the organism of the injected radiopharmaceutical agent [fr

  4. Subclinical hyperthyroidism: current concepts and scintigraphic imaging.

    Science.gov (United States)

    Intenzo, Charles; Jabbour, Serge; Miller, Jeffrey L; Ahmed, Intekhab; Furlong, Kevin; Kushen, Medina; Kim, Sung M; Capuzzi, David M

    2011-09-01

    Subclinical hyperthyroidism is defined as normal serum free thyroxine and a free triiodothyronine level, with a thyroid-stimulating hormone level suppressed below the normal range and is usually undetectable. Although patients with this diagnosis have no or few signs and symptoms of overt thyrotoxicosis, there is sufficient evidence that it is associated with a relatively higher risk of supraventricular arrhythmias as well as the acceleration or the development of osteoporosis. Consequently, the approach to the patient with subclinical hyperthyroidism is controversial, that is, therapeutic intervention versus watchful waiting. Regardless, it is imperative for the referring physician to identify the causative thyroid disorder. This is optimally accomplished by a functional study, namely scintigraphy. Recognition of the scan findings of the various causes of subclinical hyperthyroidism enables the imaging specialist to help in diagnosing the underlying condition causing thyroid-stimulating hormone suppression thereby facilitating the workup and management of this thyroid disorder.

  5. The significance of 123I-BMIPP delayed scintigraphic imaging in cardiac patients.

    Science.gov (United States)

    Akashi, Yoshihiro J; Kida, Keisuke; Suzuki, Kae; Inoue, Koji; Kawasaki, Kensuke; Yamauchi, Masahiro; Musha, Haruki; Anker, Stefan D

    2007-04-25

    Earlier studies have not fully investigated the significance of radionuclide planar imaging in cardiac patients using the fatty acid analogue 123I-beta-methyl-iodophenylpentadecanoic acid (123I-BMIPP). This study was to clarify the effectiveness of 123I-BMIPP in assessing the heart-to-mediastinum ratio (H/M) and myocardial washout rate (WR) in patients with heart disease. Myocardial 123I-BMIPP imaging was performed in 33 patients (20 with chronic heart failure [CHF] and 13 with stable angina pectoris [AP]) and 11 control subjects. Myocardial 123I-BMIPP planner images were obtained 30 min (early image) and 4 h (delayed image) after tracer injection. The left ventricular ejection fraction (LVEF) was measured by quantitative gated single photon emission computed tomography. The concentration of plasma brain natriuretic peptide (BNP) was measured before the scintigraphic study. (1) Delayed H/M was much lower in CHF than in AP (1.93 +/- 0.37 vs. 2.21 +/- 0.38, p acid metabolism disorders in patients with heart disease in both masked and unmasked conditions.

  6. Computer processing of the scintigraphic image using digital filtering techniques

    International Nuclear Information System (INIS)

    Matsuo, Michimasa

    1976-01-01

    The theory of digital filtering was studied as a method for the computer processing of scintigraphic images. The characteristics and design techniques of finite impulse response (FIR) digital filters with linear phases were examined using the z-transform. The conventional data processing method, smoothing, could be recognized as one kind of linear phase FIR low-pass digital filtering. Ten representatives of FIR low-pass digital filters with various cut-off frequencies were scrutinized from the frequency domain in one-dimension and two-dimensions. These filters were applied to phantom studies with cold targets, using a Scinticamera-Minicomputer on-line System. These studies revealed that the resultant images had a direct connection with the magnitude response of the filter, that is, they could be estimated fairly well from the frequency response of the digital filter used. The filter, which was estimated from phantom studies as optimal for liver scintigrams using 198 Au-colloid, was successfully applied in clinical use for detecting true cold lesions and, at the same time, for eliminating spurious images. (J.P.N.)

  7. Temporal contrast enhancement and parametric imaging for the visualisation of time patterns in dynamic scintigraphic imaging

    International Nuclear Information System (INIS)

    Deconinck, F.; Bossuyt, A.; Lepoudre, R.

    1982-01-01

    Image contrast, photon noise and sampling frequency limit the visual extraction of relevant temporal information in scintigraphic image series. When the Unitation is mainly due to low temporal contrast, temporal contrast enhancement will strongly improve the perceptibility of time patterns in the series. When the limitation is due to photon noise and limited temporal sampling, parametric imaging by means of the Hadamard transform can visualise temporal patterns. (WU)

  8. Is there a role for scintigraphic imaging of bone manifestations in Gaucher disease? A review of the literature

    International Nuclear Information System (INIS)

    Mikosch, P.; State Hospital Klagenfurt; Kohlfuerst, S.; Gallowitsch, H.J.; Kresnik, E.; Lind, P.; Mehta, A.B.; Hughes, D.A.

    2008-01-01

    Gaucher disease is the most prevalent inherited, lysosomal storage disease and is caused by deficient activity of the enzyme β-glucocerebrosidase. Bone and bone marrow alterations are frequent in the most prevalent non-neuronopathic form of Gaucher disease. Imaging of bone manifestations in Gaucher disease is performed by a variety of imaging methods, conventional X-ray and MRI as the most frequently and most important ones. However, different modalities of scintigraphic imaging have also been used. This article gives an overview on scintigraphic imaging with respect to bone manifestations in Gaucher disease discussing the advantages and limitations of scintigraphic imaging in comparison to other imaging methods. (orig.)

  9. Scintigraphic detection of gynaecological tumours by sup(99m)Tc-HSA blood pool imaging

    Energy Technology Data Exchange (ETDEWEB)

    Georgiou, E C; Arkas, A Z; Alevizaki, C C; Gnafakis, N [Evangelismos Hospital, Athens (Greece). Dept. of Endocrinology and Radioisotopes; Evangelismos Hospital, Athens (Greece). Gynaecology Clinic)

    1979-12-01

    Three cases of scintigraphic visualization of gynaecological tumours by sup(99m)Tc-HSA blood pool imaging are presented, i.e. one case of fibrothecoma ('cold' area visualization) and two cases of fibromyoma ('hot' area visualization). It is suggested that this technique may be useful in the preoperative evaluation of gynaecological tumours and their vascularity.

  10. Role of intensity transformation function for enhancement of bone scintigraphic images.

    Science.gov (United States)

    Pandey, Anil Kumar; Dhiman, Vishali; Sharma, Akshima; ArunRaj, Sreedharan Thankarajan; Baghel, Vivek; Patel, Chetan; Sharma, Param Dev; Bal, Chandrasekhar; Kumar, Rakesh

    2018-03-29

    The bone scintigraphic image might exceed the dynamic range (the ratio between the highest and the lowest brightness a monitor is capable of displaying) of display monitor. In this case, a high intensity area, and loss of the details of other structures in the displayed image makes the clinical interpretation a challenging task. We have investigated the role of intensity transformation function for enhancement of these types of images. Methods: Forty high dynamic range bone scintigraphic images were processed using intensity transformation (IT) function. The IT function has two parameters: threshold and slope. Keeping the threshold equal to mean counts of the image, the value of slope was varied from 1 to 20. In-house application program written in MATLAB R2013b was used to process images. Twenty output images corresponding to one input image were visually inspected by two experienced nuclear medicine (NM) physicians to select diagnostic quality images, and from their selection the standardized slope (value of slope parameter) that produced maximum numbers of diagnostic images was determined. They also rated the image quality of input and output images (at standardized slope) on scale 1 to 5 [where 1 is for poor and 5 if for the excellent diagnostic quality]. Student's t-test was used to test the significance of difference between the mean image quality score assigned to input and processed images at significance level α = 0.05. Results: The application of IT functions with standardized parameters significantly improved the quality of high dynamic range bone scintigraphic images ( P enhancement. Copyright © 2018 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

  11. Statistical and heuristic image noise extraction (SHINE): a new method for processing Poisson noise in scintigraphic images

    International Nuclear Information System (INIS)

    Hannequin, Pascal; Mas, Jacky

    2002-01-01

    Poisson noise is one of the factors degrading scintigraphic images, especially at low count level, due to the statistical nature of photon detection. We have developed an original procedure, named statistical and heuristic image noise extraction (SHINE), to reduce the Poisson noise contained in the scintigraphic images, preserving the resolution, the contrast and the texture. The SHINE procedure consists in dividing the image into 4 x 4 blocks and performing a correspondence analysis on these blocks. Each block is then reconstructed using its own significant factors which are selected using an original statistical variance test. The SHINE procedure has been validated using a line numerical phantom and a hot spots and cold spots real phantom. The reference images are the noise-free simulated images for the numerical phantom and an extremely high counts image for the real phantom. The SHINE procedure has then been applied to the Jaszczak phantom and clinical data including planar bone scintigraphy, planar Sestamibi scintigraphy and Tl-201 myocardial SPECT. The SHINE procedure reduces the mean normalized error between the noisy images and the corresponding reference images. This reduction is constant and does not change with the count level. The SNR in a SHINE processed image is close to that of the corresponding raw image with twice the number of counts. The visual results with the Jaszczak phantom SPECT have shown that SHINE preserves the contrast and the resolution of the slices well. Clinical examples have shown no visual difference between the SHINE images and the corresponding raw images obtained with twice the acquisition duration. SHINE is an entirely automatic procedure which enables halving the acquisition time or the injected dose in scintigraphic acquisitions. It can be applied to all scintigraphic images, including PET data, and to all low-count photon images

  12. Gamma camera with an original system of scintigraphic image printing incorporated

    International Nuclear Information System (INIS)

    Roux, G.

    A new gamma camera has been developed, using Anger's Principle to localise the scintillations and incorporating the latest improvements which give a standard of efficiency at present competitive for this kind of apparatus. In the general design of the system special care was devoted to its ease of employment and above all to the production of high-quality scintigraphic images, the recording of images obtained from the gamma camera posing a problem to which a solution is proposed. This consists in storing all the constituent data of an image in a cell matrix of format similar to the scope of the object, the superficial information density of the image being represented by the cell contents. When the examination is finished a special printer supplies a 35x43 cm 2 document in colour on paper, or in black and white on radiological film, at 2:1 or 1:1 magnifications. The laws of contrast representation by the colours or shades of grey are chosen a posteriori according to the organ examined. Documents of the same quality as those so far supplied by a rectilinear scintigraph are then obtained with the gamma camera, which offers its own advantages in addition. The first images acquired in vivo with the whole system, gamma camera plus printer, are presented [fr

  13. Estimation of clinical efficacy for scintigraphic images of liver, 1

    International Nuclear Information System (INIS)

    Matsumoto, Toru; Iinuma, Takeshi; Tateno, Yukio; Machida, Kikuo.

    1982-01-01

    In this study, the clinical efficacy No. 1 (diagnostic accuracy) of liver images on various liver diseases is investigated. From 8 different medical institutions the liver images of 406 cases most of which were imaged with 99mTc-phytate and confirmed for its final diagnosis by the autopsy, surgery and other techniques excluding the liver scintigraphy were collected. In order to evaluate the results of image reading, an input sheet for computer was designed to describe the confirmed diagnosis of each case. The liver images were read by 11 physicians from the 8 institutions that presented the cases and the results of reading were recorded on the work sheet for computer input. The work sheet includes abnormality in shape, size and position of the liver, position and number of SOL, and diagnosis of liver diseases, etc. By comparing the record of confirmed diagnosis and the results of image reading for individual case, various programs of analysis are being undertaken. The accuracy in detecting the SOL by means of receiver operating characteristic (ROC) analysis is presented here. The results of analysis are as follows. (1) ROC curves are rather similar in all physicians and average ROC points are TPR = 71, 80, 91%, FPR = 5, 15, 27%, respectively. (2) The SOL of size larger than 3 cm are detected more easily than those of size less than 3 cm, although number of SOL less than 3 cm is only nine cases and so variation of TPR between physicians is large. It is found that the ROC curve for many SOL of small size is almost identical to that of SOL larger than 3 cm. As to the detection of SOL larger than 3 cm, Anger camera and scanner are found to have an identical capability. (author)

  14. A paper sheet phantom for scintigraphic planar imaging. Usefulness of pouch-laminated paper source

    International Nuclear Information System (INIS)

    Takaki, Akihiro; Soma, Tsutomu; Murase, Kenya; Teraoka, Satomi; Murakami, Tomonori; Kojima, Akihiro; Matsumoto, Masanori

    2007-01-01

    In order to perform experimental measurements for evaluation of imaging device's performance, data acquisition technique, and clinical images on scintigraphic imaging, many kinds of phantoms are employed. However, since these materials are acrylic and plastic, the thickness and quality of those materials cause attenuation and scatter in itself. We developed a paper sheet phantom sealed with a pouch laminator, which can be a true radioactive source in air. In this study, the paper sheet phantom was compared to the acrylic liver phantom, with the thickness of 2 cm, which is commercially available. The results showed that although some scatter counts were contained within the image of the acrylic liver phantom, there were few scattered photons in the paper sheet phantom image. Furthermore, this laminated paper sheet phantom made handling of the source and its waste easier. If the paper sheet phantom will be designed more sophisticatedly, it becomes a useful tool for planar imaging experiments. (author)

  15. Scintigraphic images of bacterial infection using aptamers directly labeled with {sup 99m}Tc

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    Santos, S.R.; Correa, C.R.; Andrade, A.S.R., E-mail: sararoberta7@hotmail.com, E-mail: crisrcorrea@gmail.com, E-mail: antero@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil); Barros, A.L.B.; Diniz, S.O.F.; Cardoso, V.N., E-mail: brancodebarros@yahoo.com.br, E-mail: valbertcardoso@yahoo.com.br, E-mail: simoneodilia@yahoo.com.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Faculdade de Farmacia. Departamento de Analises Clinicas e Toxicologicas

    2015-07-01

    Staphylococcus aureus is specie of great medical importance and is the most commonly agent found in infections of soft tissues, bone infections and bone prostheses. In this study, aptamers selected to S. aureus were labeled by the direct method with {sup 99m}Tc and used for bacterial infection identification by scintigraphy. The radiolabeled aptamers radiochemical purity and stability were assessed by thin-layer chromatography (TLC). Three groups of Swiss mice (n=6) were used for the scintigraphic imaging studies. The first group was infected intramuscularly in the right thigh with S. aureus, the second group with C. albicans and the third group received zymosan to induce aseptic inflammation. After 24 h, radiolabeled aptamers (18 MBq) were injected by the tail vein. Scintigraphic images were acquired at 1 h and 4 h postinjection. The radiolabeling yield with {sup 99m}Tc was over 90%. The radiolabeled aptamers were stable in 0.9% saline, plasma and cysteine excess. The scintigraphic image profiles showed high uptake in the kidneys and bladder in all groups, indicating a main renal excretion consistent with the hydrophilic nature of the molecule. No accumulation of radioactivity was observed in the thyroid, stomach, liver and spleen, indicating acceptable levels of radiochemical impurities. The group infected with S. aureus showed a visible uptake in the infected right thigh at 1 h post-injection. For the control groups (C. albicans and zymosan) visible differences between the right and left thighs were not observed. The radiolabeled aptamers were able to distinguish aseptic inflammation from bacterial infection and bacterial from fungal infection. (author)

  16. Scintigraphic images of bacterial infection using aptamers directly labeled with 99mTc

    International Nuclear Information System (INIS)

    Santos, S.R.; Correa, C.R.; Andrade, A.S.R.; Barros, A.L.B.; Diniz, S.O.F.; Cardoso, V.N.

    2015-01-01

    Staphylococcus aureus is specie of great medical importance and is the most commonly agent found in infections of soft tissues, bone infections and bone prostheses. In this study, aptamers selected to S. aureus were labeled by the direct method with 99m Tc and used for bacterial infection identification by scintigraphy. The radiolabeled aptamers radiochemical purity and stability were assessed by thin-layer chromatography (TLC). Three groups of Swiss mice (n=6) were used for the scintigraphic imaging studies. The first group was infected intramuscularly in the right thigh with S. aureus, the second group with C. albicans and the third group received zymosan to induce aseptic inflammation. After 24 h, radiolabeled aptamers (18 MBq) were injected by the tail vein. Scintigraphic images were acquired at 1 h and 4 h postinjection. The radiolabeling yield with 99m Tc was over 90%. The radiolabeled aptamers were stable in 0.9% saline, plasma and cysteine excess. The scintigraphic image profiles showed high uptake in the kidneys and bladder in all groups, indicating a main renal excretion consistent with the hydrophilic nature of the molecule. No accumulation of radioactivity was observed in the thyroid, stomach, liver and spleen, indicating acceptable levels of radiochemical impurities. The group infected with S. aureus showed a visible uptake in the infected right thigh at 1 h post-injection. For the control groups (C. albicans and zymosan) visible differences between the right and left thighs were not observed. The radiolabeled aptamers were able to distinguish aseptic inflammation from bacterial infection and bacterial from fungal infection. (author)

  17. 123I-BMIPP delayed scintigraphic imaging in patients with chronic heart failure

    International Nuclear Information System (INIS)

    Kida, Keisuke; Akashi, Yoshihiro J.; Yoneyama, Kihei; Shimokawa, Mitsuhiro; Musha, Haruki

    2008-01-01

    The objective of the present study was to clarify the ability of 123 I-beta-methyl-iodophenylpentadecanoic acid ( 123 I-BMIPP) to evaluate the heart-to-mediastinum (H/M) ratio and myocardial global washout rate (WR) in patients with chronic heart failure (CHF). The severity of CHF was evaluated on the basis of the New York Heart Association (NYHA) classification. Twenty patients with CHF (13 with idiopathic dilated cardiomyopathy and 7 with ischemic cardiomyopathy) and 11 age-matched controls underwent myocardial radionuclide imaging. Scintigraphic images were obtained from each participant at the early (30 min following radio-isotope injection) and late (4 h) phases using 123 I-BMIPP. The H/M ratio and WR were calculated from planar images. Concentrations of plasma brain natriuretic peptide (BNP) were measured prior to the scintigraphic study. The 123 I-BMIPP uptake of early H/M and global WR did not significantly differ among groups, but uptake of delayed H/M was significantly lower in patients with NYHA class III than in controls (control 2.47±0.39; class III 1.78±0.28 P 123 I-BMIPP uptake of delayed H/M enhances the image of CHF severity. The myocardial WR of 123 I-BMIPP also effectively depicted the severity of CHF. (author)

  18. Scintigraphic imaging of Staphylococcus aureus infection using 99mTc radiolabeled aptamers.

    Science.gov (United States)

    Santos, Sara Roberta Dos; de Sousa Lacerda, Camila Maria; Ferreira, Iêda Mendes; de Barros, André Luís Branco; Fernandes, Simone Odília; Cardoso, Valbert Nascimento; de Andrade, Antero Silva Ribeiro

    2017-10-01

    Staphylococcus aureus is a specie of great medical importance associated with many infections as bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device related infections. Early identification of infectious foci is crucial for successful treatment. Scintigraphy could contribute to this purpose since specific radiotracers were available. Aptamers due to their high specificity have great potential for radiopharmaceuticals development. In the present study scintigraphic images of S. aureus infectious foci were obtained using specific S. aureus aptamers radiolabeled with 99m Tc. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Evaluation by scintigraphic images of musculoskeletal infection with 99mTc ciprofloxacin

    International Nuclear Information System (INIS)

    Casacó, C.A.; Hernández, A.; Perera, A.; Prats, A.; Batista, J.F.; Torres, L.A.; Quesada, R.; Sánchez, Y.; Valladares, L.; Sánchez, E.L.; Marrero, L.O.; Mustelier, E.

    2016-01-01

    Introduction: Infectious diseases present high morbidity and mortality in all countries, especially in the third world. In Cuba between 2005 and 2014, approximately 1.3% of the total deaths were killed. Orthopedic infections are among the most common. The scintigraphic methods currently used are not able to discern between a septic focus and a sterile inflammation. Radiological methods detect a bone infection only when there is significant anatomical damage. Ciprofloxacin as a drug binds and inhibits topoisomerase II or bacterial gyrase DNA. Objective: to evaluate the efficacy of 99m Tc-ciprofloxacin in the detection of osteo-articular bacterial processes. Materials and Methods: An experimental, cross-sectional, cross-sectional study was conducted involving 258 patients with suspected osteoarticular infectious processes. The presence of the lesion and the quantification and intensity of uptake in the foci of infection in images with 99m Tc-MDP (3h post-administration) and 99m Tc-ciprofloxacin (1, 4 and 24h post-administration) were visually determined. Studies of 99m Tc-ciprofloxacin were compared with Culture / Biopsy results. Results: The germ that most frequently appears in infected osteo-articular sites is staphilococcusaureus. No adverse effects were detected in any of the subjects studied. Studies with 99m Tc-MDP allow delineating infected areas but are not specific. 99mTc-ciprofloxacin shows the sites of active osteo-articular bacterial infection and when it is fixed in a septic focus gives intense captures at both 4 and 24 hours. It exhibits a sensitivity similar to 99mTc-MDP, but a significantly higher specificity. Conclusions: Scintigraphic images with 99m Tc-ciprofloxacin show sites of active osteo-articular bacterial infection with a specificity significantly higher than 99m Tc-MDP. The microbiological and scintigraphic results were positive for sepsis in 122 patients out of 219 who were sampled.

  20. Assessment of scintigraphic image quality in Single Photon Emission Computed Tomography (SPECT) using jaszczak phantom

    International Nuclear Information System (INIS)

    Eduful, E. K

    2012-01-01

    The image quality of scintigraphic images has been improved by applying a MatLab algorithm code and five different filters to an acquired image of the data spectrum (Jaszczak) phantom and the FWHM (resolution) values measured using ImageJ software. The average FWHM value recorded for the acquired image and the Matlab enhanced image were 14.246±0.205 mm and 11.609±1.458 mm respectively. The analyses performed on the acquired image showed improvements in its resolution. Combination of the MatLab algorithm code and the Trous-Wavelet filter gave the best improvement in resolution of the acquired image, with an average FWHM value of 10.261±1.381 mm. This indicates a 27.973% improvement in the FWHM value of the acquired image. The CLAHE filter, Kuwahara filter, Sigma filter Plus and filter rank, improved the resolution of the acquired image by 21.627%, 17.48%, 4.745% and 8.949% respectively. Results from the study indicate that the acquired image was improved in quality by applying the Matlab image enhancement tool and filters. The outcome of this study shows promise in aiding nuclear medicine physicians to make improved diagnostic decisions if applied to clinical cases.(au)

  1. 123I-BMIPP delayed scintigraphic imaging in patients with chronic heart failure.

    Science.gov (United States)

    Kida, Keisuke; Akashi, Yoshihiro J; Yoneyama, Kihei; Shimokawa, Mitsuhiro; Musha, Haruki

    2008-11-01

    The objective of the present study was to clarify the ability of 123I-beta-methyl-iodophenylpentadecanoic acid (123I-BMIPP) to evaluate the heart-to-mediastinum (H/M) ratio and myocardial global washout rate (WR) in patients with chronic heart failure (CHF). The severity of CHF was evaluated on the basis of the New York Heart Association (NYHA) classification. Twenty patients with CHF (13 with idiopathic dilated cardiomyopathy and 7 with ischemic cardiomyopathy) and 11 age-matched controls underwent myocardial radionuclide imaging. Scintigraphic images were obtained from each participant at the early (30 min following radio-isotope injection) and late (4 h) phases using 123I-BMIPP. The H/M ratio and WR were calculated from planar images. Concentrations of plasma brain natriuretic peptide (BNP) were measured prior to the scintigraphic study. The 123I-BMIPP uptake of early H/M and global WR did not significantly differ among groups, but uptake of delayed H/M was significantly lower in patients with NYHA class III than in controls (control 2.47 +/- 0.39; class III 1.78 +/- 0.28, P < 0.05). The uptake of delayed H/M and global WR correlated with plasma log BNP in all participants (r = -0.38, P < 0.05; 0.43, P < 0.05, respectively). These data suggest that 123I-BMIPP uptake of delayed H/M enhances the image of CHF severity. The myocardial WR of 123I-BMIPP also effectively depicted the severity of CHF.

  2. Nontraumatic femoral head necrosis. Classification of bone scintigraphic findings and diagnostic value of SPECT following planar imaging

    Energy Technology Data Exchange (ETDEWEB)

    Minoshima, Satoshi; Uchida, Yoshitaka; Anzai, Yoshimi; Uno, Kimiichi; Arimizu, Noboru [Chiba Univ. (Japan). School of Medicine

    1994-09-01

    This study was conducted to determine bone scintigraphic findings in nontraumatic femoral head avascular necrosis and diagnostic value of SPECT imaging following a conventional planar imaging. Forty-three femoral heads in twenty-six cases with idiopathic femoral head necrosis (n=2), systemic lupus erythematosus (n=22), aplastic anemia (n=1), and renal transplantation (n=1) were studied. The diagnosis for femoral head necrosis was based on magnetic resonance imaging as well as other diagnostic studies in all cases. Scintigraphic findings of planar and SPECT images were classified into six categories: normal (N); cold or decrease (C); partial increase with cold or decrease (PH+C); ring-like increase with a cold center (RH+C); partial increase (PH); diffuse and/or irregular increase (DH). Avascular necrosis was confirmed in twenty-four femoral heads, in which planar and SPECT images showed scintigraphic findings of N (n=3, 2), C (n=1, 3), PH+C (n=2, 8), RH+C (n=2, 3), PH (n=9, 2), and DH (n=7, 6), respectively. Femoral heads without avascular necrosis demonstrated planar and SPECT findings of N (n=16, 12), C (n=0, 6), and DH (n=3, 1), respectively. When considering C, PH+C, and RH+C as diagnostic findings for avascular necrosis, sensitivities of planar and SPECT images were 21% and 58%, and specificities were 100% and 68%, respectively. In nineteen femoral heads with normal planar findings (N), SPECT correctly identified avascular necrosis in two femoral heads and misidentified six normal femoral heads as avascular necrosis. In nineteen femoral heads with nondiagnostic abnormalities (PH, DH), SPECT correctly identified avascular necrosis in seven femoral heads and showed no false positive. Diagnostic planar findings in five femoral heads were concordant with SPECT diagnosis. These results indicate that SPECT imaging is most valuable when planar images show nondiagnostic abnormalities based on the proposed classification of scintigraphic findings. (author).

  3. Nontraumatic femoral head necrosis. Classification of bone scintigraphic findings and diagnostic value of SPECT following planar imaging

    International Nuclear Information System (INIS)

    Minoshima, Satoshi; Uchida, Yoshitaka; Anzai, Yoshimi; Uno, Kimiichi; Arimizu, Noboru

    1994-01-01

    This study was conducted to determine bone scintigraphic findings in nontraumatic femoral head avascular necrosis and diagnostic value of SPECT imaging following a conventional planar imaging. Forty-three femoral heads in twenty-six cases with idiopathic femoral head necrosis (n=2), systemic lupus erythematosus (n=22), aplastic anemia (n=1), and renal transplantation (n=1) were studied. The diagnosis for femoral head necrosis was based on magnetic resonance imaging as well as other diagnostic studies in all cases. Scintigraphic findings of planar and SPECT images were classified into six categories: normal (N); cold or decrease (C); partial increase with cold or decrease (PH+C); ring-like increase with a cold center (RH+C); partial increase (PH); diffuse and/or irregular increase (DH). Avascular necrosis was confirmed in twenty-four femoral heads, in which planar and SPECT images showed scintigraphic findings of N (n=3, 2), C (n=1, 3), PH+C (n=2, 8), RH+C (n=2, 3), PH (n=9, 2), and DH (n=7, 6), respectively. Femoral heads without avascular necrosis demonstrated planar and SPECT findings of N (n=16, 12), C (n=0, 6), and DH (n=3, 1), respectively. When considering C, PH+C, and RH+C as diagnostic findings for avascular necrosis, sensitivities of planar and SPECT images were 21% and 58%, and specificities were 100% and 68%, respectively. In nineteen femoral heads with normal planar findings (N), SPECT correctly identified avascular necrosis in two femoral heads and misidentified six normal femoral heads as avascular necrosis. In nineteen femoral heads with nondiagnostic abnormalities (PH, DH), SPECT correctly identified avascular necrosis in seven femoral heads and showed no false positive. Diagnostic planar findings in five femoral heads were concordant with SPECT diagnosis. These results indicate that SPECT imaging is most valuable when planar images show nondiagnostic abnormalities based on the proposed classification of scintigraphic findings. (author)

  4. 3D segmentation of scintigraphic images with validation on realistic GATE simulations

    International Nuclear Information System (INIS)

    Burg, Samuel

    2011-01-01

    The objective of this thesis was to propose a new 3D segmentation method for scintigraphic imaging. The first part of the work was to simulate 3D volumes with known ground truth in order to validate a segmentation method over other. Monte-Carlo simulations were performed using the GATE software (Geant4 Application for Emission Tomography). For this, we characterized and modeled the gamma camera 'γ Imager' Biospace"T"M by comparing each measurement from a simulated acquisition to his real equivalent. The 'low level' segmentation tool that we have developed is based on a modeling of the levels of the image by probabilistic mixtures. Parameters estimation is done by an SEM algorithm (Stochastic Expectation Maximization). The 3D volume segmentation is achieved by an ICM algorithm (Iterative Conditional Mode). We compared the segmentation based on Gaussian and Poisson mixtures to segmentation by thresholding on the simulated volumes. This showed the relevance of the segmentations obtained using probabilistic mixtures, especially those obtained with Poisson mixtures. Those one has been used to segment real "1"8FDG PET images of the brain and to compute descriptive statistics of the different tissues. In order to obtain a 'high level' segmentation method and find anatomical structures (necrotic part or active part of a tumor, for example), we proposed a process based on the point processes formalism. A feasibility study has yielded very encouraging results. (author) [fr

  5. 3D tomographic imaging with the γ-eye planar scintigraphic gamma camera

    Science.gov (United States)

    Tunnicliffe, H.; Georgiou, M.; Loudos, G. K.; Simcox, A.; Tsoumpas, C.

    2017-11-01

    γ-eye is a desktop planar scintigraphic gamma camera (100 mm × 50 mm field of view) designed by BET Solutions as an affordable tool for dynamic, whole body, small-animal imaging. This investigation tests the viability of using γ-eye for the collection of tomographic data for 3D SPECT reconstruction. Two software packages, QSPECT and STIR (software for tomographic image reconstruction), have been compared. Reconstructions have been performed using QSPECT’s implementation of the OSEM algorithm and STIR’s OSMAPOSL (Ordered Subset Maximum A Posteriori One Step Late) and OSSPS (Ordered Subsets Separable Paraboloidal Surrogate) algorithms. Reconstructed images of phantom and mouse data have been assessed in terms of spatial resolution, sensitivity to varying activity levels and uniformity. The effect of varying the number of iterations, the voxel size (1.25 mm default voxel size reduced to 0.625 mm and 0.3125 mm), the point spread function correction and the weight of prior terms were explored. While QSPECT demonstrated faster reconstructions, STIR outperformed it in terms of resolution (as low as 1 mm versus 3 mm), particularly when smaller voxel sizes were used, and in terms of uniformity, particularly when prior terms were used. Little difference in terms of sensitivity was seen throughout.

  6. In vitro evaluation, biodistribution and scintigraphic imaging in mice of radiolabeled anthrax toxins

    International Nuclear Information System (INIS)

    Dadachova, Ekaterina; Rivera, Johanna; Revskaya, Ekaterina; Nakouzi, Antonio; Cahill, Sean M.; Blumenstein, Michael; Xiao, Hui; Rykunov, Dmitry; Casadevall, Arturo

    2008-01-01

    Introduction: There is a lot of interest towards creating therapies and vaccines for Bacillus anthracis, a bacterium which causes anthrax in humans and which spores can be made into potent biological weapons. Systemic injection of lethal factor (LF), edema factor (EF) and protective antigen (PA) in mice produces toxicity, and this protocol is commonly used to investigate the efficacy of specific antibodies in passive protection and vaccine studies. Availability of toxins labeled with imageable radioisotopes would allow to demonstrate their tissue distribution after intravenous injection at toxin concentration that are below pharmacologically significant to avoid masking by toxic effects. Methods: LF, EF and PA were radiolabeled with 188 Re and 99m Tc, and their performance in vitro was evaluated by macrophages and Chinese hamster ovary cells toxicity assays and by binding to macrophages. Scintigraphic imaging and biodistribution of intravenously (IV) injected 99m Tc-and 123 I-labeled toxins was performed in BALB/c mice. Results: Radiolabeled toxins preserved their biological activity. Scatchard-type analysis of the binding of radiolabeled PA to the J774.16 macrophage-like cells revealed 6.6x10 4 binding sites per cell with a dissociation constant of 6.7 nM. Comparative scintigraphic imaging of mice injected intravenously with either 99m Tc-or 123 I-labeled PA, EF and LF toxins demonstrated similar biodistribution patterns with early localization of radioactivity in the liver, spleen, intestines and excretion through kidneys. The finding of renal excretion shortly after IV injection strongly suggests that toxins are rapidly degraded which could contribute to the variability of mouse toxigenic assays. Biodistribution studies confirmed that all three toxins concentrated in the liver and the presence of high levels of radioactivity again implied rapid degradation in vivo. Conclusions: The availability of 188 Re and 99m Tc-labeled PA, LF and EF toxins allowed us to

  7. Scintigraphic imaging with 99mTc- exorphin C in rabbits

    International Nuclear Information System (INIS)

    Ertay, T.; Uenak, P.; Tasci, C.; Zihnioglu, F.; Durak, H.

    2005-01-01

    Exorphin C is a peptide with five amino acids [(Tyr-Pro-Ile-Ser-Leu) Trifluoroacetate salt] (Sigma) that has an affinity to opioid receptor-expressing tissues and tumors. Exorphin-C was labeled with 99m Tc using glucoheptonate (GH) as bifunctional chelating agent. Then, we investigated its radiopharmaceutical potential as opioid receptor-expressing tissue on rabbits. Quality controls were performed by ITLC, paper electrophoresis and HPLC. Labeling efficiency was higher than 98%. The compound was stable for at least 5 h at room temperature. Scintigraphic imaging with 99m Tc-GH-exorphin C ( 99m Tc-GE) was performed on male Albino rabbits. Static images were obtained from anterior projection using a Camstar XR/T gamma camera at several time intervals. Although a significant amount of activity was seen in the brain, less activity was seen on receptor saturation studies at 30 min. Slight hepatobiliary excretion was seen, though the main excretion route was renal. After saturating, the receptor hepatobiliary excretion was not seen; the only excretion route was renal

  8. Interest of scintigraphic imaging in Madagascar for the diagnosis of ectopic parathyroid adenoma, about one case

    International Nuclear Information System (INIS)

    Andriantsoa, J.; Andriamanalina, T.; Ramamonjy, A.; Ranivontsoarivony, M.; Ramahandridona, G.; Razafindramboa, H.; Gizy Ratiambahoaka, D.

    2008-01-01

    This study reports the first case of ectopic parathyroid adenoma, diagnosed in the Department of Nuclear Medicine in Antananarivo. This clinical vignette illustrates the interest of the MIBI-Tc-99 m scan in locating this adenoma and its diagnostic confirmation after six years of erratic diagnosis. A whole body bone scintigraphy has also allowed to assess the state of bone metabolism and study outbreaks of fracture. The parathyroid scintigraphy was carried out after intra-venous administration of 666 MBq of MIBI- 99m Tc. Dynamic images, static early and late static were acquired with a gamma camera E-Cam Siemens. The whole body bone scan was carried out after administration of 555 MBq of M.D.P.-Tc-99 m. The results evidenced the presence of an para-aortic increased uptake area pointing to a left parathyroid adenoma. The persistence of a late left sub maxillary increased uptake area raises, however, a reservation about the existence of a second adenoma. The bone scan displayed global skeletal remodeling, non suggestive of metastases, as it was mentioned with the CT-scan. In a diagnostic tools limited environment, skeletal pain refractory to pain-killers, a chronic hypercalcemia associated with an increased parathyroid hormone level, should trigger the scintigraphic exploration in order to avoid bone and renal complications

  9. Relevance of I-BMIPP delayed scintigraphic imaging for patients with angina pectoris - a pilot study.

    Science.gov (United States)

    Koyama, Kohei; Akashi, Yoshihiro J; Kida, Keisuke; Suzuki, Kengo; Ishibashi, Yuki; Musha, Haruki; Banach, Maciej

    2011-06-01

    The study was designed to clarify the role of (123)I-β-methyl-iodophenylpentadecanoic acid ((123)I-BMIPP) in the evaluation of myocardial fatty acid metabolism in patients with stable angina pectoris (AP) before and after percutaneous coronary intervention (PCI). TEN CONTROLS (MEAN AGE: 70.4 ±10.5 years) and 12 patients with AP (mean age: 67.4 ±11.6 years) and single vessel coronary artery disease participated in the radionuclide cardiac study. Scintigraphic images were acquired at 30 min and at 4 h after (123)I-BMIPP injection to determine early and delayed BMIPP uptake, respectively. The heart-to-mediastinum (H/M) ratio and the washout rate (WR) were calculated from the planar images. All patients underwent scintigraphy one day before PCI and again 1 month after successful PCI. NO SIGNIFICANT DIFFERENCES IN THE EARLY OR DELAYED H/M RATIOS WERE OBSERVED BETWEEN THE PATIENTS AND THE CONTROLS BEFORE PCI (EARLY: 2.70 ±0.36 vs. 2.73 ±0.57; delayed: 2.26 ±0.33 vs. 2.40 ±0.43; p > 0.2 for both). The early and delayed H/M ratios remained unchanged with the comparison with before PCI (early: 2.72 ±0.27, delayed: 2.23 ±0.22; p > 0.2 for both). The global WR before PCI was significantly higher in the patients than in the control group (36.7 ±9.3%, vs. 28.1 ±8.2%, p = 0.02). However, the WR after PCI did not significantly differ between the patients and the controls (34.3 ±7.8% vs. 28.1 ±8.2%, p = 0.1). These data may suggest that the WR of (123)I-BMIPP determined from the planar images enhances the presence of myocardial ischaemia.

  10. Scintigraphic demonstration of splenosis

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, C.A.; Sakimura, I.T.; Siegel, M.E.

    1986-03-01

    A case of splenosis, or the autotransplantation of splenic tissue following trauma, was encountered unexpectedly on a routine liver scan performed in the workup of alcoholic liver disease. Confirmatory scintigraphic images using Tc-99m labeled, heat-damaged, autologous erythrocytes are presented with CT scans of the abdomen.

  11. Relevance of 123I-BMIPP delayed scintigraphic imaging for patients with angina pectoris ? a pilot study

    OpenAIRE

    Koyama, Kohei; Akashi, Yoshihiro J.; Kida, Keisuke; Suzuki, Kengo; Ishibashi, Yuki; Musha, Haruki; Banach, Maciej

    2011-01-01

    Introduction The study was designed to clarify the role of 123I-?-methyl-iodophenylpentadecanoic acid (123I-BMIPP) in the evaluation of myocardial fatty acid metabolism in patients with stable angina pectoris (AP) before and after percutaneous coronary intervention (PCI). Material and methods Ten controls (mean age: 70.4 ?10.5 years) and 12 patients with AP (mean age: 67.4 ?11.6 years) and single vessel coronary artery disease participated in the radionuclide cardiac study. Scintigraphic imag...

  12. NEPHRUS: model of intelligent multilayers expert system for evaluation of the renal system based on scintigraphic images analysis

    International Nuclear Information System (INIS)

    Silva, Jose W.E. da; Schirru, Roberto; Boasquevisque, Edson M.

    1997-01-01

    This work develops a prototype for the system model based on Artificial Intelligence devices able to perform functions related to scintigraphic image analysis of the urinary system. Criteria used by medical experts for analysis images obtained with 99m Tc+DTPA and/or 99m Tc+DMSA were modeled and a multi resolution diagnosis technique was implemented. Special attention was given to the programs user interface design. Human Factor Engineering techniques were considered so as to ally friendliness and robustness. Results obtained using Artificial Neural Networks for the qualitative image analysis and the knowledge model constructed shows the feasibility of Artificial Intelligence implementation that use 'inherent' abilities of each technique in the resolution of diagnosis image analysis problems. (author). 12 refs., 2 figs., 2 tabs

  13. In vivo comparative study of hydroxyapatite labeled with different radioisotopes: evaluation of the scintigraphic images

    Energy Technology Data Exchange (ETDEWEB)

    Couto, Renata Martinussi; Barboza, Marycel Figols de; Souza, Adriano Aparecido de; Muramoto, Emiko; Mengatti, Jair; Araujo, Elaine Bortoleti de, E-mail: rmcouto@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil). Centro de Radiofarmacia

    2008-07-01

    Rheumatoid arthritis (RA) is a chronic inflammatory disorder of joints that is characterized by the inflammation and proliferation of synovial tissues. Approximately 3% of the adult population in the world is affected by this disease which causes pain, joint immobility and disability. Adyo synovectomy (RSV) is a radiotherapeutic modality where a b--emitting radionuclide is administered locally by intra-articular injection on the form of a colloid or radiolabeled particulate. RSV is a well-accepted therapeutic procedure in inflammatory joint diseases and has been successfully employed for more than 50 years as a viable alternative to surgical and chemical synovectomy in the treatment of RA and other inflammatory arthropathies. There are several radionuclides available for this purpose such as {sup 177}Lu, {sup 90}Y, {sup 153}Sm, {sup 165}Dy, and {sup 166}Ho. Hydroxyapatite (HA) is one of the preferred particulates for this application because it is the major chemical constituent of skeletal bone and it is converted into Ca and PO4 ions in the body. In addition HA is completely eliminated over a period of six weeks. The aim of this work is to compare the in vivo stability of hydroxyapatite labeled with {sup 177}Lu, {sup 90}Y and {sup 153}Sm in order to determine the influence of the radionuclide on biological pattern. In biological studies, 100mL of labeled HAs suspended in normal saline were injected into normal knee joints of Wistar rats and the retention of the activity into the synovium was determined. Labeled particles were also injected by intravenous and intramuscular administration, to verify the biodistribution in the case of an eventual leakage of the products from the joint. Sequential scintigraphic images were acquired from 1 hour to 7 days p.i. after anesthetizing the animals with ketamine. Hydroxyapatite was radiolabeled by all radionuclides with high yield. {sup 177}Lu-HA, {sup 90}Y-HA and {sup 153}Sm-HA were retained in the joint for 7 days, showing

  14. In vivo comparative study of hydroxyapatite labeled with different radioisotopes: evaluation of the scintigraphic images

    International Nuclear Information System (INIS)

    Couto, Renata Martinussi; Barboza, Marycel Figols de; Souza, Adriano Aparecido de; Muramoto, Emiko; Mengatti, Jair; Araujo, Elaine Bortoleti de

    2008-01-01

    Rheumatoid arthritis (RA) is a chronic inflammatory disorder of joints that is characterized by the inflammation and proliferation of synovial tissues. Approximately 3% of the adult population in the world is affected by this disease which causes pain, joint immobility and disability. Adyo synovectomy (RSV) is a radiotherapeutic modality where a b--emitting radionuclide is administered locally by intra-articular injection on the form of a colloid or radiolabeled particulate. RSV is a well-accepted therapeutic procedure in inflammatory joint diseases and has been successfully employed for more than 50 years as a viable alternative to surgical and chemical synovectomy in the treatment of RA and other inflammatory arthropathies. There are several radionuclides available for this purpose such as 177 Lu, 90 Y, 153 Sm, 165 Dy, and 166 Ho. Hydroxyapatite (HA) is one of the preferred particulates for this application because it is the major chemical constituent of skeletal bone and it is converted into Ca and PO4 ions in the body. In addition HA is completely eliminated over a period of six weeks. The aim of this work is to compare the in vivo stability of hydroxyapatite labeled with 177 Lu, 90 Y and 153 Sm in order to determine the influence of the radionuclide on biological pattern. In biological studies, 100mL of labeled HAs suspended in normal saline were injected into normal knee joints of Wistar rats and the retention of the activity into the synovium was determined. Labeled particles were also injected by intravenous and intramuscular administration, to verify the biodistribution in the case of an eventual leakage of the products from the joint. Sequential scintigraphic images were acquired from 1 hour to 7 days p.i. after anesthetizing the animals with ketamine. Hydroxyapatite was radiolabeled by all radionuclides with high yield. 177 Lu-HA, 90 Y-HA and 153 Sm-HA were retained in the joint for 7 days, showing stability and usefulness as tools in the RSV treatment

  15. Scintigraphic anatomy of coronary artery disease in digital thallium-201 myocardial images

    International Nuclear Information System (INIS)

    Wainwright, R.J.

    1981-01-01

    One hundred and eight patients with single and multiple vessel coronary artery disease confirmed by arteriography were evaluated by exercise thallium-201 ( 201 Tl) myocardial scintigraphy to determine the scintigraphic appearances of specific coronary stenoses. In general proximal stenoses caused more widespread, but not necessarily more severe, myocardial tracer deficit, than distal stenoses. In particular, proximal dominant right coronary artery disease was specifically associated with extensive inferior wall tracer deficit in the anterior scintigram, whereas proximal left circumflex disease caused similar tracer depletion best visualised in the left lateral scintigram. A triad of uptake defects was caused by left anterior descending coronary artery disease; one of these defects called 'diagonal window tracer deficit' was the most useful scintigraphic sign distinguishing proximal from distal disease in the left anterior descending coronary artery. Certain scintigraphic patterns of 201 Tl myocardial accumulation appear invaluable in the noninvasive localisation of stenoses within specific coronary arteries and thus may be useful in predicting life-threatening coronary artery disease which should be confirmed by definitive coronary arteriography. The digital 201 Tl myocardial scintigram also provides an independent functional guide to the interpretation of coronary arteriograms and may be helpful in the planning of aortocoronary bypass graft surgery. (author)

  16. Comparison of de-noising techniques of scintigraphic images; Comparaison de techniques de debruitage des images scintigraphiques

    Energy Technology Data Exchange (ETDEWEB)

    Kirkove, M.; Seret, A. [Liege Univ., Imagerie Medicale Experimentale, Institut de Physique (Belgium)

    2007-05-15

    Scintigraphic images are strongly affected by Poisson noise. This article presents the results of a comparison between de-noising methods for Poisson noise according to different criteria: the gain in signal-to-noise ratio, the preservation of resolution and contrast. and the visual quality. The wavelet techniques recently developed to de-noise Poisson noise limited images are divided into two groups based on: (1) the Haar representation. 1 (2) the transformation of Poisson noise into white Gaussian noise by the Haar-Fisz transform followed by a de-noising. In this study, three variants of the first group and three variants of the second. including the adaptative Wiener filter, four types of wavelet thresholding and the Bayesian method of Pizurica were compared to Metz and Hanning filters and to Shine, a systematic noise elimination process. All these methods, except Shine, are parametric. For each of them, ranges of optimal values for the parameters were highlighted as a function of the aforementioned criteria. The intersection of ranges for the wavelet methods without thresholding was empty, and these methods were therefore not further compared quantitatively. The thresholding techniques and Shine gave the best results in resolution and contrast. The largest improvement in signal-to-noise ratio was obtained by the filters. Ideally, these filters should be accurately defined for each image. This is difficult in the clinical context. Moreover. they generate oscillation artefacts. In addition, the wavelet techniques did not bring significant improvements, and are rather slow. Therefore, Shine, which is fast and works automatically, appears to be an interesting alternative. (authors)

  17. Scintigraphic imaging of focal hypoxic tissue: development and clinical applications of 123I-IAZA

    Directory of Open Access Journals (Sweden)

    Leonard I. Wiebe

    2002-09-01

    Full Text Available Affected tissues in a number of diseases, including cancer, stroke, cardiac infarction and diabetes, develop focal tissue hypoxia during their progression. The presence of hypoxic tissue may make the disease refractory to therapy, as in the case of solid tumor therapy using low LET ionizing radiation. In other pathologies, the detection of viable but hypoxic tissues may serve as a prodromal indicator of developing disease (e.g. diabetes,or as a prognostic indicator for management of the disease (e.g. stroke. Over the past two decades, a number of hypoxia radioimaging agents have been developed and tested clinically. Of these, 18F-Fmiso and 123I-IAZA are the most widely used radiotracers for PET and SPECT/planar imaging, respectively. IAZA and Fmiso are a 2-nitroimidazoles that chemically bind to subcellular components of viable hypoxic tissues. They sensitize hypoxic tumour to the killing effects of ionizing radiation via mechanisms that mimic the radiosensitizing effects of oxygen, and are therefore called oxygen mimetics. The oxygen mimetic effect is attributable in large part to the covalent binding of reductively-activated nitroimidazole intermediates to critical cellular macromolecules. Nitroimidazoles labelled with gamma-emitting radionuclides (e.g. 18F-Fmiso and 123I-IAZA have been used as scintigraphic markers of tumour hypoxia, based on the need to identify radioresistant hypoxic tumour cells as part of the radiotherapy planning process. Broader interest in non-invasive, imaging-based identification of focal hypoxia in a number of diseases has extended hypoxia studies to include peripheral vascular disease associated with diabetes, rheumatoid arthritis, stroke, myocardial ischaemia, brain trauma and oxidative stress. In this review, the current status of hypoxia-selective studies with 123I-IAZA , an experimental diagnostic radiopharmaceutical, is reviewed with respect to its pre-clinical development and clinical applications.Os tecidos

  18. A “Proteoglycan Targeting Strategy” for the Scintigraphic Imaging and Monitoring of the Swarm Rat Chondrosarcoma Orthotopic Model

    Directory of Open Access Journals (Sweden)

    Caroline Peyrode

    2011-01-01

    Full Text Available Our lab developed 99mTc-NTP 15-5 radiotracer as targeting proteoglycans (PGs for the scintigraphic imaging of joint. This paper reports preclinical results of 99mTc-NTP 15-5 imaging of an orthotopic model of Swarm rat chondrosarcoma (SRC. 99mTc-NTP 15-5 imaging of SRC-bearing and sham-operated animals was performed and quantified at regular intervals after surgery and compared to bone scintigraphy and tumoural volume. Tumours were characterized by histology and PG assay. SRC exhibited a significant 99mTc-NTP 15-5 uptake at very early stage after implant (with tumour/muscle ratio of 1.61 ± 0.14, whereas no measurable tumour was evidenced. As tumour grew, mean tumour/muscle ratio was increased by 2.4, between the early and late stage of pathology. Bone scintigraphy failed to image chondrosarcoma, even at the later stage of study. 99mTc-NTP 15-5 imaging provided a suitable set of quantitative criteria for the in vivo characterization of chondrosarcoma behaviour in bone environment, useful for achieving a greater understanding of the pathology.

  19. Scintigraphic and MR perfusion imaging in preoperative evaluation for lung volume reduction surgery. Pilot study results

    International Nuclear Information System (INIS)

    Johkoh, Takeshi; Mueller, N.L.; Kavanagh, P.V

    2000-01-01

    To compare MR perfusion imaging with perfusion scintigraphy in the evaluation of patients with pulmonary emphysema being considered for lung volume reduction surgery. Six patients with pulmonary emphysema and two normal individuals were evaluated by MR perfusion imaging, perfusion scintigraphy, and selective bilateral pulmonary angiography. MR images were obtained with an enhanced fast gradient recalled echo with three-dimensional Fourier transformation technique (efgre 3D) (6.3/1.3; flip angle, 30 deg C; field of view, 45-48 cm; matrix, 256 x 160). The presence or absence of perfusion defects in each segment was evaluated by two independent observers. Using angiography as the gold standard, the sensitivity, specificity, and accuracy of MR perfusion imaging in detecting focal perfusion abnormalities were 90%, 87%, and 89%, respectively, while those of perfusion scintigraphy were 71%, 76%, and 71%, respectively. The diagnostic accuracy of MR perfusion imaging was significantly higher than that of scintigraphy (p<0.001, McNemar test). There was good agreement between two observers for MR perfusion imaging (kappa statistic, 0.66) and only moderate agreement for perfusion scintigraphy (kappa statistic, 0.51). MR perfusion imaging is superior to perfusion scintigraphy in the evaluation of pulmonary parenchymal perfusion in patients with pulmonary emphysema. (author)

  20. Testicular radionuclide angiography and sttatic imaging: anatomy, scintigraphic interpretation, and clinical indications

    International Nuclear Information System (INIS)

    Holder, L.E.; Martire, J.R.; Holmes, E.R. III.; Wagner, H.N. Jr.

    1977-01-01

    Radionuclide testicular angiography and static imaging is an easy, rapidly performed study. Its usefulness in separating acute testicular torsion from acute epididymitis has been confirmed. Increased angiographic perfusion with definition of the testicular and deferential arteries in the spermatic cord and the pudendal artery posteriorly is equated with inflammation. Intense increased vascularity on the blood pool image is seen in abscess and acute inflammation, while cases of tumor and trauma have mild increases. Acute or missed testicular torsion, uncomplicated hydroceles, and spermatoceles show absent vascularity. On the static images, decreased activity is characteristic of the shape and location of the avascular structure. Technical factors are stressed

  1. Scintigraphic appearance of the piriformis muscle syndrome

    International Nuclear Information System (INIS)

    Karl, R.D. Jr.; Yedinak, M.A.; Hartshorne, M.F.; Cawthon, M.A.; Bauman, J.M.; Howard, W.H.; Bunker, S.R.

    1985-01-01

    This is the first report in the nuclear medicine literature of the scintigraphic appearance of the piriformis muscle syndrome. This syndrome previously has been thought to be a purely clinical diagnosis and imaging modalities have been ignored. However, its confusing clinical presentation can lead to unnecessary surgical exploration. This case is presented to illustrate the characteristic scintigraphic pattern and suggest the role of nuclear medicine scanning in establishing the diagnosis

  2. A contribution to the improvement of the intelligibility on scintigraphic images

    International Nuclear Information System (INIS)

    Cordier, Sylvaine.

    1975-01-01

    First of all the physical conditions necessary to obtain the image of a radioactivated organ are defined, after which the characteristics of these images are analyzed in order to suggest a suitable treatment for each type of degradation. The relationships between the different parameters of the system: object to be detected, noise in the measurement, pulse response of the system etc... are expressed in mathematical formulae. It is shown that the detection system as a whole may be considered with a very good approximation as a linear filter and the generality of this approach enables it to be applied to any imagery system. Since in morphological examinations an abnormal relief is looked for in the representation of an organ the use of digital computing methods was considered as a means of showing up these reliefs from a previously restored image and the information processing aspect of the problem is considered. The generalization of two-dimensional positive unfolding is not utopian and it is found that the number of calculation to be performed is only proportional to n even when a (nxn) image is obtained [fr

  3. Model-based extraction of input and organ functions in dynamic scintigraphic imaging

    Czech Academy of Sciences Publication Activity Database

    Tichý, Ondřej; Šmídl, Václav; Šámal, M.

    2016-01-01

    Roč. 4, 3-4 (2016), s. 135-145 ISSN 2168-1171 R&D Projects: GA ČR GA13-29225S Institutional support: RVO:67985556 Keywords : blind source separation * convolution * dynamic medical imaging * compartment modelling Subject RIV: BB - Applied Statistics, Operational Research http://library.utia.cas.cz/separaty/2014/AS/tichy-0428540.pdf

  4. Scintigraphic evaluation of Lyme disease: Gallium-67 imaging of Lyme myositis

    International Nuclear Information System (INIS)

    Kengen, R.A.; Linde, M. von der; Sprenger, H.G.; Piers, D.A.

    1989-01-01

    A patient suffering from Lyme disease had cardiac conduction abnormalities, symptoms of arthritis, and myalgia. A Ga-67 image showed evidence of endomyocarditis, but intense skeletal muscle uptake pointed to Lyme myositis. Reference is made to two other case reports of Lyme myositis

  5. Scintigraphic imaging and turnover studies with iodine-131 labelled serum amyloid P component in systemic amyloidosis

    International Nuclear Information System (INIS)

    Hawkins, P.N.; Pepys, M.B.; Aprile, C.; Capri, G.; Vigano, L.; Munzone, E.; Gianni, L.; Merlini, G.

    1998-01-01

    Radiolabelled serum amyloid P component (SAP) is a specific tracer for amyloid. Iodine-123 has ideal physical characteristics for scintigraphy but is expensive and not widely available. Here we report serial imaging and turnover studies in which we labelled SAP with iodine-131, a cheap alternative isotope which would be expected to yield poorer images but permit more prolonged turnover measurements. Imaging and plasma clearance and whole body retention (WBR) of tracer were studied for up to 7 days in ten patients with proven systemic AL amyloidosis and two patients in whom the diagnosis was suspected, after i.v. administration of about 37 MBq of 131 I-SAP. Normal blood pool images were obtained in the latter two subjects and amyloidosis was subsequently refuted histologically. WBR at 48 h was 65% of the injected dose (i.d.). Among the other ten patients, amyloid deposits were identified in the spleen in eight cases, liver in five and kidneys in four; other sites that gave positive results included bone, joints and soft tissues, and the myocardium in one case. Up to 95% of the tracer localised into amyloid within 6-h, and the values for WBR became progressively more discriminating during the study period, exceeding the normal reference value ( 131 I-SAP produced diagnostic scans in every patient in this series and, coupled with the detailed turnover information, is adequate for monitoring disease progress. (orig.)

  6. Relevance of 123I-BMIPP delayed scintigraphic imaging for patients with angina pectoris – a pilot study

    Science.gov (United States)

    Koyama, Kohei; Akashi, Yoshihiro J.; Kida, Keisuke; Suzuki, Kengo; Ishibashi, Yuki; Musha, Haruki; Banach, Maciej

    2011-01-01

    Introduction The study was designed to clarify the role of 123I-β-methyl-iodophenylpentadecanoic acid (123I-BMIPP) in the evaluation of myocardial fatty acid metabolism in patients with stable angina pectoris (AP) before and after percutaneous coronary intervention (PCI). Material and methods Ten controls (mean age: 70.4 ±10.5 years) and 12 patients with AP (mean age: 67.4 ±11.6 years) and single vessel coronary artery disease participated in the radionuclide cardiac study. Scintigraphic images were acquired at 30 min and at 4 h after 123I-BMIPP injection to determine early and delayed BMIPP uptake, respectively. The heart-to-mediastinum (H/M) ratio and the washout rate (WR) were calculated from the planar images. All patients underwent scintigraphy one day before PCI and again 1 month after successful PCI. Results No significant differences in the early or delayed H/M ratios were observed between the patients and the controls before PCI (early: 2.70 ±0.36 vs. 2.73 ±0.57; delayed: 2.26 ±0.33 vs. 2.40 ±0.43; p > 0.2 for both). The early and delayed H/M ratios remained unchanged with the comparison with before PCI (early: 2.72 ±0.27, delayed: 2.23 ±0.22; p > 0.2 for both). The global WR before PCI was significantly higher in the patients than in the control group (36.7 ±9.3%, vs. 28.1 ±8.2%, p = 0.02). However, the WR after PCI did not significantly differ between the patients and the controls (34.3 ±7.8% vs. 28.1 ±8.2%, p = 0.1). Conclusions These data may suggest that the WR of 123I-BMIPP determined from the planar images enhances the presence of myocardial ischaemia. PMID:22295024

  7. Sensitivity of radiographic features and specificity of scintigraphic imaging in hand osteoarthritis

    International Nuclear Information System (INIS)

    Buckland-Wright, J.C.; MacFarlane, D.G.; Lynch, J.A.

    1995-01-01

    We undertook to determine which of the radiographic features most reliably detected the presence and disease progression in osteoarthritis in the hand; and which of the radiographic features corresponded with the radionuclide bone scan images. 32 patients with osteoarthritis had X5 macroradiographs taken of their wrists and hands at 6 monthly intervals over an 18 month period. The high magnification and resolution of microfocal radiography permitted quantitative detection of the extent and change in joint space width, subchondral sclerosis, osteophytosis and juxtaarticular radiolucencies. 4-hour technetium 99 m methylene bisphophonate bone scans were taken at 0 and 12 months and the activity of the tracer uptake at each joint scored. The latter was compared with the radiographic features at each visit and the changes between visits analysed. In hand OA the most sensitive radiographic parameters for detecting disease were osteophytes, subchondral sclerosis and justaarticular radiolucencies, with radionuclide imaging demonstrating the increased activity in bone formation associated with the growth and remodelling of osteophytes. Changes in the number and size of osteophytes and joint space narrowing were the only reliable and sensitive parameters for assessing disease progression. We conclude that in osteoarthritis, the bony changes progress significantly before the occurrence of radiographically evident joint space narrowing indicative of cartilage thinning. (authors). 48 refs., 2 tabs., 11 figs

  8. [Regional liver circulation and scintigraphic imaging of portal circulation with 133Xe].

    Science.gov (United States)

    Kroiss, A

    1984-01-01

    Regional hepatic blood flow has been determined by 4 methods with the aid of the 133Xe washout technique: scintisplenoportography (direct application of 133Xe into the spleen by means of a thin needle); arterial method (133Xe is injected into the A. hepatica by means of a catheter); retrograde-venous method (133Xe administered by an occluding hepatic vein catheter); percutaneous intrahepatic method (133Xe administered directly into the parenchyma by means of a Chiba needle). Ad 1.: Scintisplenoportography (SSP) was executed with 97 patients: 8 patients with a healthy liver presented a hepatic blood flow of 103.37 +/- 11.5 ml/100 g/min. 4 patients with a chronic hepatitis showed a hepatic blood flow of 105.67 +/- 10.2 ml/100 g/min. In 38 patients with compensated cirrhosis, hepatic blood flow was determined with 58.15 +/- 11.5 ml/100 g/min and 19 patients with decompensated cirrhosis showed a blood flow of 34.54 +/- 7.2 ml/100 g/min. Of the 19 patients, who did not present any liver image, 2 patients suffered from a prehepatic block, 1 patient (female) from a posthepatic block, the rest were decompensated cirrhoses. In 5 patients suffering from steatosis only collateral circulation was determined and in 4 patients the spleen could not be punctured. In the patients with compensated and decompensated cirrhosis of the liver, hepatic blood flow differentiated significantly (p less than 0.001) from patients with healthy livers and chronic hepatitis. In the patients with bioptically assured steatosis only the washout constant was determined. Reproducibility of this method was tested in 4 patients and no statistical difference of hepatic blood flow values could be found and the correlation coefficient amounted to 0.9856. The advantage of SSP lies in the possibility of recording the portal vein circulation: cranial collaterals were found in 33 patients, 2 patients had caudal collaterals exclusively and 29 patients cranial and caudal collaterals. 33 cirrhosis patients

  9. 99mTc-ceftriaxone, as a targeting radiopharmaceutical for scintigraphic imaging of infectious foci due to Staphylococcus aureus in mouse model

    International Nuclear Information System (INIS)

    Akram Fazli; Mojtaba Salouti; Mohammad Mazidi

    2013-01-01

    99m Tc-labeled antibiotics have opened an exciting field of research in infectious diseases diagnosis. Direct labeling of ceftriaxone with 99mTc was carried out using the various amounts of ceftriaxone and SnCl 2 ·2H 2 O at different pH and incubation time intervals to find the highest radiochemistry efficiency with high stability at room temperature and human blood serum. ITLC-SG and HPLC were performed to measure the radiochemical purity of the conjugate. The binding study showed 45 % specific binding to Staphylococcus aureus. The biodistribution study and scintigraphic imaging showed the localization of 99m Tc-ceftriaxone at the site of infection in comparison with normal and inflamed muscles with high sensitivity and specificity in mouse model. The results showed that 99m Tc-ceftriaxone is a promising candidate as a targeting radiopharmaceutical for Staphylococcal infection imaging in humans which needs further investigations. (author)

  10. In vitro radionuclide therapy and in vivo scintigraphic imaging of alpha fetoprotein producing hepatocellular carcinoma by targeted sodium iodide symporter gene expression

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kwang Il; Lee, Yong Jin; Lee, Tae Sup; Song, Inho; Cheon, Gi Jeong; Lim, Sang Moo; Kang, Joo Hyun [Korea Institute of Radiological and Medical and Medical Sciences, Seoul (Korea, Republic of); Chung, June Key [Seoul National Univ. College of Medicine, Seoul (Korea, Republic of)

    2012-03-15

    This study aimed to develop a gene expression targeting method for specific imaging and therapy of alpha fetoprotein (AFP) producing hepatocellular carcinoma (HCC) cells, using an adenovirus vector containing the human sodium/iodide symporter (hNIS) gene driven by an AFP enhancer/promoter. The recombinant adenovirus vector, AdAFPhNIS (containing the hNIS gene driven by human AFP enhancer/promoter) was prepared. After in vitro infection by the adenovirus, hNIS gene expression in AFP producing cells and in AFP nonproducing cells was investigated using {sup 125}I uptake assay and semi quantitative reverse transcription polymerase chain reaction (RT-PCR). The killing effect of {sup 131}I vitro clonogenic assay. In addition, tumor bearing mice were intravenously injected with the adenovirus, and scintigraphic images were obtained. The expression of hNIS was efficiently demonstrated by {sup 125}I uptake assay in AFP producing cells, but not in AFP nonproducing cells. AFP producing HCC targeted gene expression was confirmed at the mRNA level. Furthermore, in vitro clonogenic assay showed that hNIS gene expression induced by AdAFPhNIS infection in AFP producing cells caused more sensitivity to {sup 131}I than that in AFP nonproducing cells. Injected intravenously in HuH-7 tumor xenografts mice by adenovirus, the functional hNIS gene expression was confirmed in tumor by in vivo scintigraphic imaging. An AFP producing HCC was targeted with an adenovirus vector containing the hNIS gene using the AFP enhancer/promoter in vitro and in vivo. These findings demonstrate that AFP producing HCC specific molecular imaging and radionuclide gene therapy are feasible using this recombinant adenovirus vector system.

  11. In vitro radionuclide therapy and in vivo scintigraphic imaging of alpha fetoprotein producing hepatocellular carcinoma by targeted sodium iodide symporter gene expression

    International Nuclear Information System (INIS)

    Kim, Kwang Il; Lee, Yong Jin; Lee, Tae Sup; Song, Inho; Cheon, Gi Jeong; Lim, Sang Moo; Kang, Joo Hyun; Chung, June Key

    2012-01-01

    This study aimed to develop a gene expression targeting method for specific imaging and therapy of alpha fetoprotein (AFP) producing hepatocellular carcinoma (HCC) cells, using an adenovirus vector containing the human sodium/iodide symporter (hNIS) gene driven by an AFP enhancer/promoter. The recombinant adenovirus vector, AdAFPhNIS (containing the hNIS gene driven by human AFP enhancer/promoter) was prepared. After in vitro infection by the adenovirus, hNIS gene expression in AFP producing cells and in AFP nonproducing cells was investigated using 125 I uptake assay and semi quantitative reverse transcription polymerase chain reaction (RT-PCR). The killing effect of 131 I vitro clonogenic assay. In addition, tumor bearing mice were intravenously injected with the adenovirus, and scintigraphic images were obtained. The expression of hNIS was efficiently demonstrated by 125 I uptake assay in AFP producing cells, but not in AFP nonproducing cells. AFP producing HCC targeted gene expression was confirmed at the mRNA level. Furthermore, in vitro clonogenic assay showed that hNIS gene expression induced by AdAFPhNIS infection in AFP producing cells caused more sensitivity to 131 I than that in AFP nonproducing cells. Injected intravenously in HuH-7 tumor xenografts mice by adenovirus, the functional hNIS gene expression was confirmed in tumor by in vivo scintigraphic imaging. An AFP producing HCC was targeted with an adenovirus vector containing the hNIS gene using the AFP enhancer/promoter in vitro and in vivo. These findings demonstrate that AFP producing HCC specific molecular imaging and radionuclide gene therapy are feasible using this recombinant adenovirus vector system

  12. Application of a general-purpose scintigraphic scanner to transverse-section (tomographic) gamma-ray imaging

    International Nuclear Information System (INIS)

    Bradstock, P.A.; Milward, R.C.

    1976-01-01

    The paper describes the recent application of a general-purpose commercial scintigraphic scanner to transverse-section radioisotope tomography. The principle of the method is to obtain the distribution of radioactive material in a thin transverse slice of the body or brain, from a mathematical reconstruction using the measured transverse projections of the activity within that slice. The usefulness of the radioisotope section-scanning technique for clinical diagnosis, as evidenced from one year's use of the machine at the Midland Centre for Neurology and Neurosurgery, Birmingham, U.K., is briefly discussed. (orig.) [de

  13. Fatigue stress fractures of the pubic ramus in the army: imaging features with radiographic, scintigraphic and MR imaging findings

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Sang Woo; Lee, Chang Hyun [The Armed Forces Capital Hospital, Seongnam (Korea, Republic of)

    2005-03-15

    Although fatigue fractures are not unusual in athletes and military personnel those of the pubic ramus are rare. We report three cases of fatigue fractures of the inferior pubic rami in two male recruits and one female military cadet. On the initial radiograph, most of the lesions were subtle and easy to overlook. However, bone scintigraphy provided more distinct images that allowed easy and early detection of lesion, and MR imaging presented more diagnostic information, which allowed a precise diagnosis.

  14. Fast renal trapping of porcine Luteinizing Hormone (pLH shown by 123I-scintigraphic imaging in rats explains its short circulatory half-life

    Directory of Open Access Journals (Sweden)

    Locatelli Alain

    2003-10-01

    Full Text Available Abstract Background Sugar moieties of gonadotropins play no primary role in receptor binding but they strongly affect their circulatory half-life and consequently their in vivo biopotencies. In order to relate more precisely hepatic trapping of these glycoproteic hormones with their circulatory half-life, we undertook a comparative study of the distribution and elimination of porcine LH (pLH and equine CG (eCG which exhibit respectively a short and a long half-life. This was done first by following half-lives of pLH in piglets with hepatic portal circulation shunted or not. It was expected that such a shunt would enhance the short half-life of pLH. Subsequently, scintigraphic imaging of both 123I-pLH and 123I-eCG was performed in intact rats to compare their routes and rates of distribution and elimination. Methods Native pLH or eCG was injected to normal piglets and pLH was tested in liver-shunted anæsthetized piglet. Blood samples were recovered sequentially over one hour time and the hormone concentrations were determined by a specific ELISA method. Scintigraphic imaging of 123I-pLH and 123I-eCG was performed in rats using a OPTI-CGR gamma camera. Results In liver-shunted piglets, the half-life of pLH was found to be as short as in intact piglets (5 min. In the rat, the half-life of pLH was also found to be very short (3–6 min and 123I-pLH was found to accumulate in high quantity in less than 10 min post injection at the level of kidneys but not in the liver. 123I-eCG didn't accumulate in any organ in the rats during the first hour, plasma concentrations of this gonadotropin being still elevated (80% at this time. Conclusion In both the porcine and rat species, the liver is not responsible for the rapid elimination of pLH from the circulation compared to eCG. Our scintigraphic experiments suggest that the very short circulatory half-life of LH is due to rapid renal trapping.

  15. Scintigraphic myocardial imaging with sup(99m)Tc-labelled pyrophosphate of experimentally produced cardiomyopathy in dogs

    Energy Technology Data Exchange (ETDEWEB)

    Duska, F.; Novak, J.; Vizda, J.; Kubicek, J.; Kafka, P.; Mazurova, Y.; Bradna, P.

    1981-12-01

    Scintigraphic examination of the myocardium using sup(99m)Tc-labelled pyrophosphate was carried out in 10 dogs with experimentally produced cardiomyopathy. This was brought by introvenous administration of high doses of adrenalin and theophylline. The scan was positive in 8 out of 10 dogs. Hot foci were very extensive. The degree of accumulation was however low (2+). Histological examination of the myocardium using the light microscope showed only scarcely distinguishable damage to the tissue without the presence of necrosis. ECG examinations were normal in all cases. By means of sup(99m)Tc-labelled pyrophosphate even very small myocardial disorders can thus be detected. This fact may be of clinical importance for an early diagnosis of heart lesions.

  16. Scintigraphic supervision of osteitis

    International Nuclear Information System (INIS)

    Manigault, L.; Sureau, B.; Wioland, M.; Perez, R.

    1975-01-01

    On the assumption that isotopic examinations of the bone metabolism and especially the scintigraphic method could give valuable results in the observation of osteitis patients treated with antibiotics, four cases of this disease were selected and followed regularly every three or four months for at least a year. Several bone scintigraphs were carried out with a scintillation camera after intraveinous injection of technetium-labelled pyrophosphate and the hyperfixation variations of the osteitis centre are given as a function of time. It is shown that bone scintigraphy gives an exact picture of the dimensions and morphology of lesions caused by an osteitis centre and above all, if repeated, enables the development of the infected region to be estimated. It seems that the healing of osteitis can be judged from scintigraphic evidence. Scintigraphy may be considered as a means to check the efficiency of an antibiotic treatment [fr

  17. Scintigraphic imaging with technetium-99M-labelled ceftizoxime is a reliable technique for the diagnosis of deep sternal wound infection in rats

    Energy Technology Data Exchange (ETDEWEB)

    Costa, Paulo Henrique Nogueira; Diniz, Simone Odilia Fernandes; Cardoso, Valbert Nascimento; Tarabal, Bernardo; Takenaka, Isabella; Braga, Otavio; Vidigal, Paula Vieira Teixeira; Gelape, Claudio Leo; Araujo, Ivana Duval, E-mail: phnc@uol.com.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil)

    2015-07-01

    Purpose: to evaluate whether scintigraphy with technetium-99m-labeled ceftizoxime ({sup 99m}Tc-CFT) can differentiate mediastinitis from aseptic inflammation associated with sternotomy. Methods: twenty female Wistar rats were randomly distributed into four groups: S (control) -partial upper median sternotomy with no treatment; SW (control) - sternotomy and treatment of sternal wounds with bone wax; SB - sternotomy and infection with Staphylococcus aureus; SWB - sternotomy with bone wax treatment and bacterial infection. Scintigraphy with {sup 99m}Tc-CFT was performed eight days after surgery and images were collected 210 and 360 min after infusion of the radiopharmaceutical. Results: no animals exhibited clinical signs of wound infection at the end of the experiment, although histological data verified acute inflammatory response in those experimentally infected with bacteria. Scintigraphic images revealed that tropism of {sup 99m}Tc-CFT to infected sternums was greater than to their non-infected counterparts. Mean counts of radioactivity in bacteria-infected sternal regions (SB and SWB) were significantly higher (p = 0.0007) than those of the respective controls (S and SW).Conclusion: scintigraphy with technetium-99m-labeled ceftizoxime is a method that can potentially detect infection post sternotomy and differentiate from aseptic inflammation in animals experimentally inoculated with S. aureus (author)

  18. Boron nitride nanotubes radiolabeled with ⁹⁹mTc: preparation, physicochemical characterization, biodistribution study, and scintigraphic imaging in Swiss mice.

    Science.gov (United States)

    Soares, Daniel Crístian Ferreira; Ferreira, Tiago Hilário; Ferreira, Carolina de Aguiar; Cardoso, Valbert Nascimento; de Sousa, Edésia Martins Barros

    2012-02-28

    In the present study, boron nitride nanotubes (BNNTs) were synthesized from an innovative process and functionalized with a glycol chitosan polymer in CDTN (Centro de Desenvolvimento da Tecnologia Nuclear) laboratories. As a means of studying their in vivo biodistribution behavior, these nanotubes were radiolabeled with (99m)Tc and injected in mice. Their size, distribution, and homogeneity were determined by photon correlation spectroscopy (PCS), while their zeta potential was determined by laser Doppler anemometry. The morphology and structural organization were evaluated by scanning electron microscopy (SEM). The functionalization in the nanotubes was evaluated by thermogravimetry analysis (TGA) and Fourier transformer infrared spectroscopy. The results showed that BNNTs were obtained and functionalized successfully, reaching a mean size and dispersity deemed adequate for in vivo studies. The BNNTs were also evaluated by ex vivo biodistribution studies and scintigraphic imaging in healthy mice. The results showed that nanostructures, after 24h, having accumulated in the liver, spleen and gut, and eliminated via renal excretion. The findings from this study reveal a potential application of functionalized BNNTs as new potential drugs or radioisotope nanocarriers to be applied in therapeutic procedures. Copyright © 2011 Elsevier B.V. All rights reserved.

  19. The Joint Master Operational Planner

    Science.gov (United States)

    2016-04-04

    Operational Planner Program, that will produce planners that are able to understand the strategic- operational environment, properly advise commanders, and...Planner Program, that will produce planners that are able to understand the strategic-operational environment, properly advise commanders, and devise...states struggle to exercise even nominal power within their borders, and the people see the government as an entity that seeks only to keep itself in

  20. Scintigraphic demonstration of tracheo-esophageal fistula

    International Nuclear Information System (INIS)

    Dunn, E.K.; Man, A.C.; Lin, K.J.; Kaufman, H.D.; Solomon, N.A.

    1983-01-01

    A tracheo-esophageal fistula, developed following radiotherapy for an esophageal carcinoma, was vividly demonstrated by radionuclide imaging. The abnormality was later confirmed by a barium esophagram and endoscopic examinations. The scintigraphic procedure, making use of a Tc-99m sulfur colloid swallow, appears to be a simple alternative method use of a Tc-99m sulfur colloid swallow, appears to be a simple alternative method that may be clinically useful for the diagnosis of such a condition

  1. Nephrus: expert system model in intelligent multilayers for evaluation of urinary system based on scintigraphic image analysis

    International Nuclear Information System (INIS)

    Silva, Jorge Wagner Esteves da; Schirru, Roberto; Boasquevisque, Edson Mendes

    1999-01-01

    Renal function can be measured noninvasively with radionuclides in a extremely safe way compared to other diagnosis techniques. Nevertheless, due to the fact that radioactive materials are used in this procedure, it is necessary to maximize its benefits, therefore all efforts are justifiable in the development of data analysis support tools for this diagnosis modality. The objective of this work is to develop a prototype for a system model based on Artificial Intelligence devices able to perform functions related to cintilographic image analysis of the urinary system. Rules used by medical experts in the analysis of images obtained with 99m Tc+DTPA and /or 99m Tc+DMSA were modeled and a Neural Network diagnosis technique was implemented. Special attention was given for designing programs user-interface. Human Factor Engineering techniques were taking in account allowing friendliness and robustness. The image segmentation adopts a model based on Ideal ROIs, which represent the normal anatomic concept for urinary system organs. Results obtained using Artificial Neural Networks for qualitative image analysis and knowledge model constructed show the feasibility of Artificial Neural Networks for qualitative image analysis and knowledge model constructed show feasibility of Artificial Intelligence implementation that uses inherent abilities of each technique in the medical diagnosis image analysis. (author)

  2. Gallium 67 scintigraphic examination of dilated myocardiopathies

    International Nuclear Information System (INIS)

    Lanfranchi, J.; Sachs, R.N.; Beaudet, B.; Deblock, C.; Tellier, P.

    1989-01-01

    Twenty-seven patients were diagnosed as having dilated cardiomyopathies, based on increases in the cardiothoracic index > 0.50, in the diastolic and systolic diameters of the left ventricle, and in the telediastolic volume of the left ventricle, which was indexed by body surface determined by contrast ventriculography. They underwent gallium 67 scintigraphic examination of the myocardium, in order to non-invasively detect the presence of an inflammatory infiltrate. Fifteen of them also had endomyocardial biopsies and all had virology check-up. The results were disappointing. Only in one case was the scintigraphic image undeniably positive; in 20 other patients the findings were dubious or negative. This technique did not demonstrate the presence of an inflammatory infiltrate and thus an association between myocarditis and dilated cardiomyopathy, could not be established [fr

  3. Methodological approaches to planar and volumetric scintigraphic imaging of small volume targets with high spatial resolution and sensitivity

    International Nuclear Information System (INIS)

    Mejia, J.; Galvis-Alonso, O.Y.; Braga, J.; Correa, R.; Leite, J.P.; Simoes, M.V.

    2009-01-01

    Single-photon emission computed tomography (SPECT) is a non-invasive imaging technique, which provides information reporting the functional states of tissues. SPECT imaging has been used as a diagnostic tool in several human disorders and can be used in animal models of diseases for physiopathological, genomic and drug discovery studies. However, most of the experimental models used in research involve rodents, which are at least one order of magnitude smaller in linear dimensions than man. Consequently, images of targets obtained with conventional gamma-cameras and collimators have poor spatial resolution and statistical quality. We review the methodological approaches developed in recent years in order to obtain images of small targets with good spatial resolution and sensitivity. Multi pinhole, coded mask- and slit-based collimators are presented as alternative approaches to improve image quality. In combination with appropriate decoding algorithms, these collimators permit a significant reduction of the time needed to register the projections used to make 3-D representations of the volumetric distribution of target's radiotracers. Simultaneously, they can be used to minimize artifacts and blurring arising when single pinhole collimators are used. Representation images are presented, which illustrate the use of these collimators. We also comment on the use of coded masks to attain tomographic resolution with a single projection, as discussed by some investigators since their introduction to obtain near-field images. We conclude this review by showing that the use of appropriate hardware and software tools adapted to conventional gamma-cameras can be of great help in obtaining relevant functional information in experiments using small animals. (author)

  4. Methodological approaches to planar and volumetric scintigraphic imaging of small volume targets with high spatial resolution and sensitivity

    Energy Technology Data Exchange (ETDEWEB)

    Mejia, J.; Galvis-Alonso, O.Y. [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Faculdade de Medicina. Dept. de Biologia Molecular], e-mail: mejia_famerp@yahoo.com.br; Braga, J. [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Div. de Astrofisica; Correa, R. [Instituto Nacional de Pesquisas Espaciais (INPE), Sao Jose dos Campos, SP (Brazil). Div. de Ciencia Espacial e Atmosferica; Leite, J.P. [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Dept. de Neurologia, Psiquiatria e Psicologia Medica; Simoes, M.V. [Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), SP (Brazil). Dept. de Clinica Medica

    2009-08-15

    Single-photon emission computed tomography (SPECT) is a non-invasive imaging technique, which provides information reporting the functional states of tissues. SPECT imaging has been used as a diagnostic tool in several human disorders and can be used in animal models of diseases for physiopathological, genomic and drug discovery studies. However, most of the experimental models used in research involve rodents, which are at least one order of magnitude smaller in linear dimensions than man. Consequently, images of targets obtained with conventional gamma-cameras and collimators have poor spatial resolution and statistical quality. We review the methodological approaches developed in recent years in order to obtain images of small targets with good spatial resolution and sensitivity. Multi pinhole, coded mask- and slit-based collimators are presented as alternative approaches to improve image quality. In combination with appropriate decoding algorithms, these collimators permit a significant reduction of the time needed to register the projections used to make 3-D representations of the volumetric distribution of target's radiotracers. Simultaneously, they can be used to minimize artifacts and blurring arising when single pinhole collimators are used. Representation images are presented, which illustrate the use of these collimators. We also comment on the use of coded masks to attain tomographic resolution with a single projection, as discussed by some investigators since their introduction to obtain near-field images. We conclude this review by showing that the use of appropriate hardware and software tools adapted to conventional gamma-cameras can be of great help in obtaining relevant functional information in experiments using small animals. (author)

  5. Methodological approaches to planar and volumetric scintigraphic imaging of small volume targets with high spatial resolution and sensitivity

    Directory of Open Access Journals (Sweden)

    J. Mejia

    2009-08-01

    Full Text Available Single-photon emission computed tomography (SPECT is a non-invasive imaging technique, which provides information reporting the functional states of tissues. SPECT imaging has been used as a diagnostic tool in several human disorders and can be used in animal models of diseases for physiopathological, genomic and drug discovery studies. However, most of the experimental models used in research involve rodents, which are at least one order of magnitude smaller in linear dimensions than man. Consequently, images of targets obtained with conventional gamma-cameras and collimators have poor spatial resolution and statistical quality. We review the methodological approaches developed in recent years in order to obtain images of small targets with good spatial resolution and sensitivity. Multipinhole, coded mask- and slit-based collimators are presented as alternative approaches to improve image quality. In combination with appropriate decoding algorithms, these collimators permit a significant reduction of the time needed to register the projections used to make 3-D representations of the volumetric distribution of target’s radiotracers. Simultaneously, they can be used to minimize artifacts and blurring arising when single pinhole collimators are used. Representation images are presented, which illustrate the use of these collimators. We also comment on the use of coded masks to attain tomographic resolution with a single projection, as discussed by some investigators since their introduction to obtain near-field images. We conclude this review by showing that the use of appropriate hardware and software tools adapted to conventional gamma-cameras can be of great help in obtaining relevant functional information in experiments using small animals.

  6. Evaluation of radiolabelled annexin A5 for scintigraphic imaging of cell processes (necrosis/apoptosis) in cardiovascular diseases

    International Nuclear Information System (INIS)

    Sarda-Mantel, L.

    2007-03-01

    Annexin A5, a 35KDa protein, specifically binds with high affinity to phosphatidylserine (P.S.) which is actively redistributed to the external leaflet of plasmic membranes in apoptotic cells and activated platelets. Annexin A5 radiolabelled with 99m Tc( 99m Tc-ANX5) was developed by Strauss (stanford, Usa) to image apoptosis in vivo: tumours cells apoptosis induced by chemo-radiotherapy, ischemia/reperfusion lesions in animals and patients, graft rejection. Additionally, many in vitro data suggest that annexin A5 also stains necrosis (membrane disruption), which occurs in all types of cell death. This preclinical work aimed to evaluate the potential interest of 99m Tc-ANX5 imaging as a clinical tool in cardiovascular diseases. Four studies performed in rat models of myocardial infarction by coronary ligation and ischemia-reperfusion, and in rat models of subacute and acute (isoproterenol-induced) myocarditis show the ability of 99m Tc-ANX5 to detect in vivo cardio myocytes death by apoptosis and necrosis. Another study demonstrates that 99m Tc-ANX5 is highly accurate to evaluate in vivo the biological activity of parietal thrombus in a rat model of elastase-induced abdominal aortic aneurysm. These results suggest that 99m Tc-ANX5 imaging could be used in patients for non invasive diagnosis, prognostic evaluation in acute myocarditis and in various thrombotic cardiovascular diseases. (author)

  7. Diagnosis of lumbosacral diskospondylosis in a bucking bull assisted by high-definition thermal and nuclear scintigraphic imaging.

    Science.gov (United States)

    Caldwell, Marc; Passler, Thomas; Purohit, Ram C; Pascoe, David; Wolfe, Dwight F

    2017-03-01

    CASE DESCRIPTION An 8-year-old Brahman-cross bull was evaluated for left hind limb lameness of 2 months' duration. The lameness was first noticed during a rodeo bucking performance, immediately after the bull appeared to land inappropriately on the affected limb. CLINICAL FINDINGS Physical examination findings revealed left hind limb lameness, ataxia, and left-sided epaxial muscle atrophy. Palpation per rectum along the lumbar portion of the vertebral column revealed evidence of exostosis of the ventral aspect. High-definition infrared thermal imaging revealed a pattern of reduced skin temperature in the area of the left lumbar and gluteal regions suggestive of a disruption in the sympathetic control of peripheral blood flow. Nuclear scintigraphy revealed a focal area of increased radioisotope uptake on the left ventrolateral aspect of the L2-3 intervertebral joint. A presumptive diagnosis of ventrolateral vertebral spondylosis resulting in spinal nerve impingement was made. TREATMENT AND OUTCOME 200 mg of methylprednisolone was epidurally injected at the site of the lesion, and treatment with polysulfated glycosaminoglycans was initiated (500 mg, IM, every 4 days for 7 treatments, then monthly thereafter). The lameness and ataxia observed in the left hind limb resolved within 1 week after treatment began. Subsequently, the bull was discharged from the hospital and was used successfully for semen collection and live-cover breeding. CLINICAL RELEVANCE Use of thermography for the bull of this report provided additional insight into neurovascular physiologic function that classical imaging modalities are unable to provide and, when combined with nuclear scintigraphy, aided in identifying the most critical lesion in a complex clinical case.

  8. NEPHRUS: model of intelligent multilayers expert system for evaluation of the renal system based on scintigraphic images analysis; NEPRUS: modelo de sistema especialista em multicamadas inteligentes para avaliacao do sistema urinario baseado na analise de imagens cintilograficas

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Jose W.E. da; Schirru, Roberto [Universidade Federal, Rio de Janeiro, RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia; Boasquevisque, Edson M. [Universidade do Estado, Rio de Janeiro, RJ (Brazil). Servico de Medicina Nuclear

    1997-10-01

    This work develops a prototype for the system model based on Artificial Intelligence devices able to perform functions related to scintigraphic image analysis of the urinary system. Criteria used by medical experts for analysis images obtained with {sup 99m} Tc+DTPA and/or {sup 99m} Tc+DMSA were modeled and a multi resolution diagnosis technique was implemented. Special attention was given to the programs user interface design. Human Factor Engineering techniques were considered so as to ally friendliness and robustness. Results obtained using Artificial Neural Networks for the qualitative image analysis and the knowledge model constructed shows the feasibility of Artificial Intelligence implementation that use `inherent` abilities of each technique in the resolution of diagnosis image analysis problems. (author). 12 refs., 2 figs., 2 tabs.

  9. A Means for the Scintigraphic Imaging of Regional Brain Dynamics. Regional Cerebral Blood Flow and Regional Cerebral Blood Volume

    Energy Technology Data Exchange (ETDEWEB)

    Potchen, E. J.; Bentley, R.; Gerth, W.; Hill, R. L.; Davis, D. O. [Washington University School Of Medicine, St. Louis, MO (United States)

    1969-05-15

    The use of freely diffusable inert radioactive gas as a washout indicator to measure regional cerebral blood flow has become a standardized kinetic procedure in many laboratories. Recent investigations with this technique have led us to conclude that we can reliably distinguish regional flow with perfusion against regional flow without perfusion from the early portion of the curve. Based on a detailed study of the early curve kinetics in patients with and without cerebral vascular disease we have defined the sampling duration necessary for application of the Anger gamma camera imaging process to regional changes in cerebral radioactivity. Using a standard camera and a small computer, a procedure has been developed and based upon entire field to determine the time of maximum height followed by analysis of the data in a matrix. This will permit a contour plot presentation of calculated regional cerebral blood flow in millilitres per 100 grams perfused brain per minute. In addition, we propose to augment this data by the display of regional non-perfusion blood flow versus regional cerebral flow with perfusion. Preliminary investigation on sampling duration, and Compton scattering were prerequisite to clinical scintigraphy of regional cerebral blood flow. In addition, the method of interface for the conventional Anger gamma camera to digital computers used in this procedure are discussed. Applications to further assess regional cerebral dynamics by scintigraphy are presented. (author)

  10. Do road planners produce more 'honest numbers' than rail planners?

    DEFF Research Database (Denmark)

    Næss, Petter; Flyvbjerg, Bent; Buhl, Søren L.

    2006-01-01

    Based on a review of available data from a database on large-scale transport infrastructure projects, this paper investigates the hypothesis that traffic forecasts for road links in Europe are geographically biased with underestimated traffic volumes in metropolitan areas and overestimated traffic...... volumes in remote regions. The present data do not support this hypothesis. Since previous studies have shown a strong tendency to overestimated forecasts of the number of passengers on new rail projects, it could be speculated that road planners are more skilful and/or honest than rail planners. However......, during the period when the investigated projects were planned (up to the late 1980s), there were hardly any strong incentives for road planners to make biased forecasts in order to place their projects in a more flattering light. Future research might uncover whether the change from the ‘predict...

  11. Congenital vascular malformations in scintigraphic evaluation

    International Nuclear Information System (INIS)

    Pilecki, Stanisław; Gierach, Marcin; Gierach, Joanna; Świętaszczyk, Cyprian; Junik, Roman; Lasek, Władysław

    2014-01-01

    Congenital vascular malformations are tumour-like, non-neoplastic lesions caused by disorders of vascular tissue morphogenesis. They are characterised by a normal cell replacement cycle throughout all growth phases and do not undergo spontaneous involution. Here we present a scintigraphic image of familial congenital vascular malformations in two sisters. A 17-years-old young woman with a history of multiple hospitalisations for foci of vascular anomalies appearing progressively in the upper and lower right limbs, chest wall and spleen. A Parkes Weber syndrome was diagnosed based on the clinical picture. Due to the occurrence of new foci of malformations, a whole-body scintigraphic examination was performed. A 12-years-old girl reported a lump in the right lower limb present for approximately 2 years, which was clinically identified as a vascular lesion in the area of calcaneus and talus. Phleboscintigraphy visualized normal radiomarker outflow from the feet via the deep venous system, also observed in the superficial venous system once the tourniquets were released. In static and whole-body examinations vascular malformations were visualised in the area of the medial cuneiform, navicular and talus bones of the left foot, as well as in the projection of right calcaneus and above the right talocrural joint. People with undiagnosed disorders related to the presence of vascular malformations should undergo periodic follow-up to identify lesions that may be the cause of potentially serious complications and to assess the results of treatment. Presented scintigraphic methods may be used for both diagnosing and monitoring of disease progression

  12. Scintigraphic findings on 99mTc-MDP, 99mTc-sestamibi and 99mTc-HMPAO images in Gaucher's disease

    International Nuclear Information System (INIS)

    Mariani, G.; Molea, N.; La Civita, L.; Porciello, G.; Lazzeri, E.; Ferri, C.

    1996-01-01

    We report here on the use of the lipophilic cationic complex technetium-99m sestamibi ( 99m Tc-MIBI), employed as an indicator of increased cellular density and metabolic activity, to evaluate Gaucher cell infiltrates in the bone marrow; 99m Tc-hexametazime ( 99m Tc-HMPAO) was also employed, as a pure indicator of lipidic infiltration in the bone marrow. A 67-year-old patient with known type 1 Gaucher's disease presented with a painful left hip and knee and difficulty in gait subsequent to traumatic fracture of the left femoral neck that had required implant of a fixation screw-plaque. Bone scan with 99m Tc-methylene diphosphonate revealed reduced uptake at the distal metaphyseal-epiphyseal femoral region. In addition, whole-body maps and spot-view acquisitions of the thighs and legs were recorded at both 30 min and 2.5 h after the injection of 99m Tc-MIBI: the scintigraphic pattern clearly showed increased uptake at several sites involved by Gaucher deposits in the bone marrow (both knees, with variable intensity in different areas), matching the bone changes detected by conventional x-ray. The target to non-target ratios slowly decreased with time, from an average value of 2.25 in the early scan to an average value of 2 in the delayed scan. The lipid-soluble agent 99m Tc-HMPAO exhibited a superimposable scintigraphic pattern of accumulation at the involved sites, though with lower target to non-target ratios (1.27-1.48). The results obtained in this patient suggest a potential role of 99m Tc-MIBI in the scintigraphic evaluation of Gaucher's lipid deposits in the bone marrow. If the results are confirmed in other patients, this radiopharmaceutical would offer clear advantages over 133 Xe because of its wider availability and greater practicality (i.v. administration of 99m Tc-MIBI versus inhalation of 133 Xe, and use of a single gamma camera instead of two as with 133 Xe). (orig.). With 3 figs

  13. Scintigraphic defecography in various anorectal disorders

    Energy Technology Data Exchange (ETDEWEB)

    Ishii, Yuji; Oya, Masatoshi; Ishikawa, Hiroshi [Dokkyo Univ., School of Medicine, Saitama (Japan). Koshigaya Hospital

    1998-04-01

    Scintigraphic defecography was performed using {sup 99m}Tc-DATA to quantitatively evaluate defecation in 26 patients after low anterior resection of rectal cancer (LAP-group), 19 patients with chronic constipation (C-group), 11 patients with miscellaneous anal symptoms (AN-group), and 12 normal volunteers. After introducing semi-solid artificial stool containing {sup 99m}Tc-DTPA into the rectum, right lateral images of the anorectum were serially obtained during voluntary evacuation. From the time activity curve of the whole rectum, the half emptying time (T1/2) and the percentage of rectal evacuation (evacuation ratio) were calculated. Three abnormal patterns were identified: the flat type in which a temporary elevation of the RI activity, usually recorded in normal volunteers at the beginning of evacuation, was not recorded; the slow type in which T1/2 was over 20 seconds; and the poor evacuation type in which evacuation ratio was less than 80%. In the LAR-group, all the patients having very low anastomosis showed abnormal patterns irrespective of the type of reconstruction (straight or colonic J-pouch). In the C-group, 10 patients who had either slow pattern or poor evacuation pattern were suggested to have outlet obstruction. In the AN-group, the evacuation pattern differed from patient to patient. Scintigraphic defecography is useful in identifying abnormal evacuation in various anorectal disorders. (author)

  14. Scintigraphic defecography in various anorectal disorders

    International Nuclear Information System (INIS)

    Ishii, Yuji; Oya, Masatoshi; Ishikawa, Hiroshi

    1998-01-01

    Scintigraphic defecography was performed using 99m Tc-DATA to quantitatively evaluate defecation in 26 patients after low anterior resection of rectal cancer (LAP-group), 19 patients with chronic constipation (C-group), 11 patients with miscellaneous anal symptoms (AN-group), and 12 normal volunteers. After introducing semi-solid artificial stool containing 99m Tc-DTPA into the rectum, right lateral images of the anorectum were serially obtained during voluntary evacuation. From the time activity curve of the whole rectum, the half emptying time (T1/2) and the percentage of rectal evacuation (evacuation ratio) were calculated. Three abnormal patterns were identified: the flat type in which a temporary elevation of the RI activity, usually recorded in normal volunteers at the beginning of evacuation, was not recorded; the slow type in which T1/2 was over 20 seconds; and the poor evacuation type in which evacuation ratio was less than 80%. In the LAR-group, all the patients having very low anastomosis showed abnormal patterns irrespective of the type of reconstruction (straight or colonic J-pouch). In the C-group, 10 patients who had either slow pattern or poor evacuation pattern were suggested to have outlet obstruction. In the AN-group, the evacuation pattern differed from patient to patient. Scintigraphic defecography is useful in identifying abnormal evacuation in various anorectal disorders. (author)

  15. Evaluation of the use of technetium Tc 99m diethylenetriamine pentaacetic acid and technetium Tc 99m dimercaptosuccinic acid for scintigraphic imaging of the kidneys in green iguanas (Iguana iguana).

    Science.gov (United States)

    Greer, Leah L; Daniel, Gregory B; Shearn-Bochsler, Valerie I; Ramsay, Edward C

    2005-01-01

    To evaluate the use of scintigraphy involving technetium Tc 99m diethylenetriamine pentaacetic acid ((99m)Tc-DTPA) or technetium Tc 99m dimercaptosuccinic acid ((99m)Tc-DMSA) for the determination of kidney morphology and function in green iguanas (Iguana iguana). 10 healthy iguanas weighing >1.6 kg. Renal scintigraphy was performed by use of (99m)Tc-DTPA in 6 of the iguanas and by use of (99m)Tc-DMSA in all 10 iguanas. After the injection of (99m)Tc-DMSA, scans were performed for each iguana at intervals during a 20-hour period. Renal biopsies were performed in all 10 iguanas after the final scintigraphic evaluation. In iguanas, the use of (99m)Tc-DTPA for renal scintigraphy was nondiagnostic because of serum protein binding and poor renal uptake of the isotope; mean +/- SD (99m)Tc-DTPA bound to serum proteins was 48.9 +/- 9.9%. Renal uptake of (99m)Tc-DMSA produced distinct visualization of both kidneys. Renal uptake and soft tissue clearance of (99m)Tc-DMSA increased over the 20-hour imaging period; mean +/- SD renal uptake of (99m)Tc-DMSA was 11.31 +/- 3.06% at 20 hours. In each of the 10 iguanas, ultrasonographic and histologic examinations of biopsy specimens from both kidneys revealed no abnormalities. Results indicate that the kidneys of iguanas can be evaluated scintigraphically by use of (99m)Tc-DMSA; this technique may be potentially useful for the diagnosis of renal failure in iguanas.

  16. Planner and nuclear crisis relocation

    International Nuclear Information System (INIS)

    Platt, R.H.

    1984-01-01

    Criticism of the Federal Emergency Management Agency (FEMA) plans to relocate two-thirds of the American people one week before a nuclear attack has been so intense that planners have renamed the crisis relocation plan to Integrated Emergency Management. A careful study of plans for the town of Greenfield, Massachusetts show that they are not only unworkable, but would seriously weaken the country even if no attack occurred. Recent warnings of a global climatic catastrophe and nuclear winter in the wake of a nuclear exchange underscore the need to denounce relocation policies as dangerous. Planners should take the lead in emphasizing the long-term consequences and informing the public that there is no civil defense against nuclear war. 7 references

  17. Vertical Launch System Loadout Planner

    Science.gov (United States)

    2015-03-01

    United States Navy USS United States’ Ship VBA Visual Basic for Applications VLP VLS Loadout Planner VLS Vertical Launch System...with 32 gigabytes of random access memory and eight processors, General Algebraic Modeling System (GAMS) CPLEX version 24 (GAMS, 2015) solves this...problem in ten minutes to an integer tolerance of 10%. The GAMS interpreter and CPLEX solver require 75 Megabytes of random access memory for this

  18. Planner concepts in IMRT planning

    International Nuclear Information System (INIS)

    Sahoo, Suvendu Kr.; Rath, A.K.; Patnaik, S.; Mishra, S.K.

    2008-01-01

    IMRT is the most sophisticated, innovative, three- dimensional conformal radiation treatment that delivers highly focused radiation with minimal impact to surrounding normal tissue. As it is a computer control technique, the planar should have adequate knowledge to execute the plan in proper way other wise it is very difficult to get the optimal plan. In this article we want to high light, planner should have the basic concepts before starting the IMRT planning

  19. Liver scintigraphic features associated with alcoholism

    International Nuclear Information System (INIS)

    Drum, D.E.; Beard, J.O.

    1978-01-01

    The relationships between scintigraphic features and clinical alcoholism were studied by review of 2406 liver scintiphotos. Two distinct patterns were significantly associated with alcoholism: heterogeneous distribution of radiocolloid in the liver, and jointly increased uptake of tracer by the spleen and vertebral bone marrow. A total of 13 overall patterns were found to distinguish, with considerable reliability, alcoholics from all other patients. This finding reflects the frequency with which alcohol abuse is associated with hepatic dysfunction in hospital patients. These observations indicate an important role for the nuclear medicine physician in detection of alcoholism among patients referred for liver-spleen imaging, and they form a basis for comparison with the diagnostic efficacy of other methods of evaluating diffuse liver diseases

  20. Scintigraphic appearances of Gaucher's disease

    International Nuclear Information System (INIS)

    Okada, Junichi; Uchiyama, Guio; Hayakawa, Kazushige; Araki, Tsutomu; Hayashi, Sanshin; Yamada, Kayoko; Seto, Kazuhiko

    1985-01-01

    Gaucher's disease is an inborn error of metabolism in which glucocerebroside accumlates within reticuloendotherial cells of spleen, liver and bone marrow. The scintigraphic appearances are described in a 19-year-old man with Gaucher's disease. The colloid scan showed increased uptake in the lung and bone marrow of legs where the reticuloendotherial system was activated. The bone scan demonstrated increased activity in the metaphyseal and diaphyseal region infiltrated by Gaucher's cell. Ga-67 was thought to be accumlated in the progressive focus of the disease. (author)

  1. Scintigraphic ventriculography and stress testing

    International Nuclear Information System (INIS)

    Goris, M.L.; Hung, J.; Debusk, R.F.

    1982-01-01

    Scintigraphic stress ventriculography yields information which is complex and defies description by the difference in ejection fraction between rest and maximum exercise only. The complexity results in part from the ''derived'' nature of the ejection fraction measurement, which is physiologically secondary to stroke volume and end-diastolic volume. Furthermore, the nature of the stress test in which the pulse (stress) is not independent from the response forces an analysis which considers ''when'' as much as ''what'' happens. Automation in data processing, however, has made oversimplification unnecessary and allows a more exhaustive but correct analysis

  2. Scintigraphic findings in ankylosing spondylitis

    International Nuclear Information System (INIS)

    Lentle, B.C.; Russell, A.S.; Percy, J.S.; Jackson, F.I.

    1977-01-01

    A prospective study of bone scintigraphic findings has been carried out in 63 patients, firmly diagnosed as having ankylosing spondylitis. In addition to abnormal uptake of the radiotracer at the sacroiliac joints, a peripheral arthropathy has been a common finding, particularly in the proximal joints, occurring in up to 50 percent of patients. Increased uptake of radiotracer in the spine has also been found both diffusely and focally. Focal increases have been noted at the apophyseal joints in 40 percent of patients and in three patients with a sterile intervertebral diskitis, an unusual complication of this disease only diagnosed in two patients after bone scintigraphy

  3. Scintigraphic findings in ankylosing spondylitis.

    Science.gov (United States)

    Lentle, B C; Russell, A S; Percy, J S; Jackson, F I

    1977-06-01

    A prospective study of bone scintigraphic findings has been carried out in 63 patients, firmly diagnosed as having ankylosing spondylitis. In addition to abnormal uptake of the radiotracer at the sacroiliac joints, a peripheral arthropathy has been a common finding, particularly in the proximal joints, occurring in up to 50% of patients. Increased uptake of radiotracer in the spine has also been found both diffusely and focally. Focal increases have been noted at the apophyseal joints in 40% of patients and in three patients with a sterile intervertebral diskitis, an unusual complication of this disease only diagnosed in two patients after bone scintigraphy.

  4. Scintigraphic evaluation of brain death

    International Nuclear Information System (INIS)

    Park, C. H.; Bai, M. S.; Cho, K. K.; Kim, S. J.; Yoon, S. N.; Cho, C. W.

    1997-01-01

    A law recognizing brain death is a life saving legal measure in patients suffering from badly diseased organs such as kidney, liver, heart, and lung. Such law is being discussed for legalization at the Korean National Assembly. There are various criteria used for brain death in western world and brain scintiscan is one of them. However, the scintiscan is not considered in establishing brain death in the draft of the law. The purpose of this report is to spread this technique in nuclear medicine society as well as in other medical societies. We evaluated 7 patients with clinical suspicion of brain death by various causes. The patient's age ranged from 5 to 39 years. We used 5-20mCi 99m Tc-HMPAO (d.1-hexamethyl propylene amine oxime) or ECD (Ethyl Cysteinate Dimer), lipophilic agents that cross BBB (blood brain barrier). A dynamic study followed by static or SPECT (single photon emission tomography) was performed. Interpretive criteria used for brain death were 1) no intracranial circulation 2) no brain uptake. The second criteria is heavily used. Five of 7 patients were scintigraphically brain dead and the remaining 2 had some brain uptake excluding the diagnosis of scintigraphic brain death. In conclusion, cerebral perfusion study using a lipophilic brain tracer offers a noninvasive, rapid, easy, accurate and reliable mean in the diagnosis of brain death. We believe that this modality should be included in the criteria of brain death in the draft of the proposed Korean law

  5. Scintigraphic Evaluation in Primary Hyperparathyroidism

    International Nuclear Information System (INIS)

    Ghita, S.; Mazilu, C.; Marinescu, G.; Mititelu, R.; Rambu, A.; Murgoci, P.; Codorean, I.

    2006-01-01

    corresponding to those found at bone scan (left femur, right humerus, patellae); another focal uptake in the right shoulder region, visible on the posterior image. Further investigations: US, IRM, CT confirm the presence of tumour and provide precise data regarding the morphology and localization: a tumour of 50/34/25 mm with solid and cystic components and benign features developed in the left anterior cervical space, between trachea, cervical vessels and SCM, in contact with the inferior pole of the left thyroid lobe. CT of right shoulder region confirms the presence of a tumour the right scapula with features consistent with the diagnosis of brown tumour. There is also a tumour developed on the posterior aspect of the right humerus. PTH 1248.0 pg/ml (N 15-65). Minimal surgical intervention tumour ablation, followed by normalization of calcium levels. Histopathology: parathyroid adenoma. Favourable evolution of clinical and laboratory parameters. Discussion. Clinical presentation was unspecific and misleading. Based on the 'metabolic' information, bone scan was able suggest the correct diagnosis and to reorient the entire management of this patient. However, we took into account all data available: benign aspect of bone lesions on Rx, the high number of giant cells of osteoclastic type in the previously assessed tumor were concordant with the diagnostic. The scintigraphic examination with 'metabolic' radiotracer was able to identify the presence of a parathyroid adenoma. Early whole body acquisitions revealed sites of osteitis fibrosa cystica/brown tumours with better accuracy than bone scan. Further investigations were necessary to confirm the presence of tumour and to provide useful data regarding the morphology and localization. Conclusions. Bone scan has to be mandatory in the evaluation of all bone tumours, being a simple diagnostic tool which provides data about the number and localization of bone lesions, but also regarding the metabolic status of the skeleton. The

  6. Scintigraphic evaluation of gastroesophageal reflux

    International Nuclear Information System (INIS)

    Malmud, L.S.; Fisher, R.S.

    1983-01-01

    When patients have symptomatic gastroesophageal reflux disease, their symptoms usually respond to conventional therapeutic measures. In some patients, however, the symptoms may persist despite the application of standard treatment regimens. It is in these instances that the clinician may employ extensive diagnostic tests to determine the cause of the patient's complaints. Because the introduction of gastroesophageal scintigraphy, a number of other techniques were employed to evaluate gastroesophageal reflux. These include barium esophagography, barium cineesophagography; endoscopy; esophageal mucosal biopsy; esophageal manometry; the acid-clearance test; and acid-reflux testing. Each of the nonscintigraphic techniques has a limitation either in its sensitivity or in the requirement for endogastric intubation. In addition, with the exception of the scintigraphic method, none of the tests permits quantitation of reflux

  7. Scintigraphic investigation of sacroiliac disease

    International Nuclear Information System (INIS)

    Lentle, B.C.; Russell, A.S.; Percy, J.S.; Jackson, F.I.

    1977-01-01

    Bone scintigraphs obtained with both technetium-99m polyphosphate and technetium-99m pyrophosphate have been abnormal at the sacroiliac joints of 44 patients with definite ankylosing spondylitis (AS). Because of the normal registration of the sacroiliac joints on bone scintigraphy, it has been necessary to develop a profile-scan technique to quantify the abnormality that proves to be significantly different from the normal finding. In 17 patients with a strong clinical suspicion of AS but normal radiographs, the sacroiliac joints have frequently been abnormal. This finding is meaningful because there is a common occurrence in this group of the histocompatibility antigen HL A-B27, known to be a marker of AS. We also note the frequency of abnormal sacroiliac scintigrams in 26 patients with rheumatoid arthritis and in a group of other diseases--Crohn's disease, uveitis, psoriasis, ulcerative colitis, and Reiters' disease--all of which share some of the manifestations of AS

  8. Airport Movement Area Closure Planner, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR research develops an automation tool improving temporary and permanent runway closure management. The Movement Area Closure Planner (MACP) provides airport...

  9. Scintigraphic instruments and techniques in nuclear medicine

    International Nuclear Information System (INIS)

    Bornand, B.; Soussaline, F.

    1977-03-01

    The development of new radiopharmaceuticals, cyclotron-produced radionuclides and improvement of detector, scanner and gamma camera characteristics have enable a remarkable recent progress in scintigraphic techniques for organ visualization and functional studies. Using a variety of techniques, positron cameras, section scanners, gamma holography, tomographic imaging appear to be playing an increasing important role. Data processing techniques, for example image processing and three dimensional reconstruction have significantly increased their impact. The principal research work and advances in technique achieved up to 1972 are summarized and the subjects which have been further exploited are outlined. The main section comprises references and abstracts of articles from scientific journals and conference proceedings (191 articles and 221 papers mentioned) for the period 1972-1975 to illustrate advances in this domain: Excerpta Medica (Nuclear Medicine) Abstract Journals and Nuclear Science Abstracts (1972-1975) were used as abstracting publications. This survey is completed with an index of authors and subject-matters. Eleven thesis are mentionned in an appendix [fr

  10. Histiocytosis X: Scintigraphic and roentgenological findings

    International Nuclear Information System (INIS)

    Fezoulidis, I.; Wickenhauser, J.; Schurawitzki, H.; Gritzmann, N.

    1987-01-01

    The aim of this study was to compare the roentgenological and scintigraphic osseous changes in 25 resp. 18 patients with histiocytosis X and to analyse them. In particular, it was also interesting to discuss the divergent reports in the literature in respect of scintigraphic storage behaviour. In all patients examined before initiation of therapy (39 osseous foci) high activities were found scintigraphically. The extension of the scintigraphically active zone was much greater than the corresponding translucencies on the X-ray film. On the other hand, patients after therapy still showed foci on the X-ray film whereas the scan had already become inactive. This striking discrepancy between scan findings before and after therapy could be one of the reasons for divergent literature reports on this problem. (orig.) [de

  11. Scintigraphic And Ultrasonic Determinations of Thyroid Volume

    International Nuclear Information System (INIS)

    Sarsono; Ismanto; Kunto, W; Hayati, N; Irma, S H

    1996-01-01

    A study has been done on the determination of thyroid volume by scintigraphic method in comparison to ultrasonographic technique, which involved a healthy woman volunteer, 5 women patients and a man patient with thyroid diseases. Scintigraphic examination upon the patient's thyroid was performed using a gamma camera 20 minutes following the injection of 55.5 Mbq (1.5 mCi) Tc-99m pertechnetate. A computer, with a dedicated program, coupled to the gamma camera was employed in the calculation of thyroid volume based on the scintigraphic data. Subsequent to the scintigraphic study, ultrasonographic determination of thyroid volume was then carried out. Correlation test that was applied to the outcome of the two methods of thyroid volume determination resulted in an excellent coefficient of correlation, R, which was 0.99. This showed a very good correlation between these two different techniques of thyroid volume determination

  12. PHOTOGRAMMETRIC MISSION PLANNER FOR RPAS

    Directory of Open Access Journals (Sweden)

    F. Gandor

    2015-08-01

    Full Text Available This paper presents a development of an open-source flight planning tool for Remotely Piloted Aircraft Systems (RPAS that is dedicated to high-precision photogrammetric mapping. This tool contains planning functions that are usually available in professional mapping systems for manned aircrafts as well as new features related to GPS signal masking in complex (e.g. mountainous terrain. The application is based on the open-source Java SDK (Software Development Kit World Wind from NASA that contains the main geospatial components facilitating the development itself. Besides standard planning functions known from other mission planners, we mainly focus on additional features dealing with safety and accuracy, such as GPS quality assessment. The need for the development came as a response for unifying mission planning across different platforms (e.g. rotary or fixed wing operating over terrain of different complexity. A special attention is given to the user interface, that is intuitive to use and cost-effective with respect to computer resources.

  13. Scintigraphic features of cirrhosis of the liver

    Energy Technology Data Exchange (ETDEWEB)

    Bell, E; Biersack, H J; Altland, H; Albrecht, M; Winkler, C

    1980-09-01

    A retrospective study of 101 patients with histologically confirmed cirrhosis of the liver and portal hypertension was carried out in order to evaluate the accepted scintigraphic criteria. In only 20% were all the essential criteria present. The absence of generally accepted important scintigraphic signs does not exclude the diagnosis of cirrhosis of the liver. Specificity of liver scintigraphy in cirrhosis of the liver is fairly low, but sensitivity of the method is almost 100%.

  14. A Theoretical and Experimental Study of the Subtraction of Two Scintigraphic Images - As Applied to Visualization of the Pancreas; Etude Theorique et Experimentale de la Soustraction de Deux Images Scintigraphiques

    Energy Technology Data Exchange (ETDEWEB)

    Desgrez, A.; Razafindramamba, V.; Saint-Laurent, J. de; Kellershohn, C. [CEA, Service Hospitalier Frederic Joliot, Orsay (France)

    1969-05-15

    Some scintigraphic studies are limited because the tissue being depicted is not selective with respect to the radioactive product available. For example, the radioactivity of the circulating blood interferes with mercury scanning of bucco-pharyngeal tumours. Scintigraphy of the pancreas is likewise impeded by localization of selenomethionine in the liver. Similarly, certain types of liver incorporation impair the visualization of insufficiency in the right kidney. One solution to this problem is to use two different labelled compounds to produce two images and then subtract one from the other so as to separate out the tissue to be depicted. The paper deals with the various problems involved in such subtraction. For example, exact spatial coincidence ofthedata to be subtracted can be ensured only by simultaneous recording of the two images; aconsecutive recording, even if it is fast, may be detrimental. The operation often consists in a double technique: suppression of the unwanted tissue by subtraction and amplification of the contrast between the tissue under investigation and residual background noise. These two operations, subtraction and amplification, relate to variable magnitudes; the resolution of the final image is thus a function of certain statistical parameters, which are also discussed. In studies carried out on the pancreas, attention is paid to the respective advantages and conditions of spectrometric separation of the various products which can be used for subtraction; the value of labelled rose bengal, which can also be used for eliminating certain intestinal loops, is stressed. A description is given of two types of apparatus which can be used in making the subtraction. The first and cheaper device involves storing the data obtained on four-track magnetic tape; the second and more rapid method utilizes the memory of a 4096-channel analyser. With both of these devices it is possible to make several subtractions during a single examination and the

  15. My fuel treatment planner: a user guide.

    Science.gov (United States)

    Robin L. Biesecker; Roger D. Fight

    2006-01-01

    My Fuel Treatment Planner (MyFTP) is a tool for calculating and displaying the financial costs and potential revenues associated with forest fuel reduction treatments. It was designed for fuel treatment planners including those with little or no background in economics, forest management, or timber sales. This guide provides the information needed to acquire, load, and...

  16. Scintigraphic assessment of colostomy irrigation.

    Science.gov (United States)

    Christensen, P.; Olsen, N.; Krogh, K.; Laurberg, S.

    2002-09-01

    OBJECTIVE: This study aims to evaluate colonic transport following colostomy irrigation with a new scintigraphic technique. MATERIALS AND METHODS: To label the bowel contents 19 patients (11 uncomplicated colostomy irrigation, 8 complicated colostomy irrigation) took 111In-labelled polystyrene pellets one and two days before investigation. 99mTc-DTPA was mixed with the irrigation fluid to assess its extent within the bowel. Scintigraphy was performed before and after a standardized washout procedure. The colon was divided into three segments 1: the caecum andascending colon; 2: the transverse colon; 3: the descending and sigmoid colon. Assuming ordered evacuation of the colon, the contribution of each colonic segment to the total evacuation was expressed as a percentage of the original segmental counts. These were added to reach a total defaecation score (range: 0-300). RESULTS: In uncomplicated colostomy irrigation, the median defaecation score was 235 (range: 145-289) corresponding to complete evacuation of the descending and transverse colon and 35% evacuation of the caecum/ascending colon. In complicated colostomy irrigation it was possible to distinguish specific emptying patterns. The retained irrigation fluid reached the caecum in all but one patient. CONCLUSION: Scintigraphy can be used to evaluate colonic emptying following colostomy irrigation.

  17. Imaging evaluation of several diseases of the salivary glands and surrounding structures. A preliminary report on sialographic, computed tomographic, ultrasonographic, and scintigraphic findings

    Energy Technology Data Exchange (ETDEWEB)

    Yoshimura, Yasuro; Oka, Masafumi; Harada, Toshio; Sugihara, Takahide; Kishimoto, Hirofumi; Matsuura, Ryozi; Santho, Eri; Tanaka, Masahiko; Matsumoto, Ken

    1987-12-01

    This clinical study presents 15 patients with lesions of the major salivary glands and surrounding tissues, and describes the importance of imaging diagnosis of their diseases. The availability of imaging diagnosis was intended to, 1) demonstrate the pathological conditions as either an extrinsic or an intrinsic lesion of the salivary gland, 2) depict the important structures such as facial nerve, and blood vessels, and to clarify the relationship between them and the lesion, 3) provide a clearer grasp of the extent of the lesion, especially when the lesion is a tumor, 4) help to discriminate between inflammation from a tumor which is malignant and from a lesion which is benign, 5) facilitate discussion and detection of metastases in the regional lymph nodes and remote organs, 6) help with early and precise detection of recurrence after primary treatment and/or in the follow-up period.

  18. Modeling and analysis of dynamic scintigraphic data for measurement of cardiac perfusion and performance

    International Nuclear Information System (INIS)

    Twieg, D.B.

    1977-01-01

    Clinical scintigraphy is the technique of imaging the distributions of gamma-ray-emitting tracers within a patient's body. The increasingly popular small nuclear medicine computer has greatly facilitated the use of mathematical models for interpretation of scintigraphic data, and has made it possible for the clinician and the researcher to extract from the scintigraphic data information not otherwise available. The purpose of this work was to investigate several models used in dynamic scintigraphic studies of the heart. The Xenon washout method of measuring myocardial perfusion is discussed. The use of single-compartment, multi-compartment, and noncompartmental models are critically examined, and the influence of multiexponential components on monoexponential fits for perfusion measurement from Xenon washouts is investigated. A model of cardiac pump function is developed which allows for incompetent valves at the input and output of the ventricular chamber. An iterative method is used in conjunction with the model to estimate forward and regurgitant flows from simulated noisy scintigraphic data and from patient data. Unlike previously available methods, the method presented here was developed to allow noninvasive determination of both mitral and aortic regurgitation. Simulation results were successful, and preliminary studies in a few patients were encouraging. An investigation is presented into the relationship between the count-volume and geometric scintigraphic methods of estimating left ventricular ejection fraction, an important index of the contractile state of the myocardial muscle. A bias due to failure to account for the effects of Poisson noise was found in one popular method for ejection measurement

  19. Hepatic hydro thorax: patient with pleural effusion to the right presenting tracer migration to the contralateral thorax projection on early scintigraphic images

    International Nuclear Information System (INIS)

    Ichiki, W.A.; Ribeiro, V.P.B.; Gusman, L.; Coura Filho, G.B.; Sapienza, M.T.; Ono, C.R; Watanabe, T.; Costa, P.L.A.; Hironaka, F.; Cerri, G.G.; Buchpiguel, C.A.

    2008-01-01

    Full text: Introduction: Hepatic hydrothorax is a significant pleural effusion, greater than 500 mL, that appears as a clinical manifestation of portal hypertension in patients with advanced cirrhosis, in the absence of cardiopulmonary disease. Its mechanisms may be explained by migration of ascitic fluid through diaphragm defects. Radioisotope scintigraphy may contribute for the diagnostic of hepatic hydrothorax. Case report: Female, 79 years old, with a history of hepatic cirrhosis due to hepatitis B virus, without primary pulmonary or heart disease. She presented worsening of clinical ascites and dyspnoea, and it was diagnosed an extensive right pleural effusion. She underwent a thoracocentesis with a drainage of 2000 mL of light yellow-citrine fluid with transudate features. The pleural effusion quickly relapsed, leading the hypothesis of a hepatic hydrothorax. A scintigraphy was requested to assess peritoneo-pleural shunt. A dose of 370 MBq (10 mCi) of 99m Tc sulfur colloid was instilled intraperitoneally. Static images involving the thorax and upper abdomen were acquired at 10, 20, 30 and 40 minutes and 4 hours after injection. At 10 minutes the radiotracer was seen on the left side of the thoracic region. The scintigraphy was repeated three days later, just after new thoracocentesis, due to the tracer progression to the left side of the thorax differed to the location of pleural effusion. Likewise, until 4 hours of the second study, the radiotracer was seen again on the left side of the thorax. However, a delayed image of 24 showed accumulation of the radiotracer in the right pleural cavity, confirming peritoneo-pleural shunt as cause of pleural effusion in this patient. Discussion: Hydrothorax is an uncommon complication in patients with decompensated hepatic cirrhosis. Its mechanisms are still not well elucidated, however, it is known that presence of defects in the diaphragm associated with the imbalance of ascitic fluid volume and the pleural absorptive

  20. Hepatic hydro thorax: patient with pleural effusion to the right presenting tracer migration to the contralateral thorax projection on early scintigraphic images

    Energy Technology Data Exchange (ETDEWEB)

    Ichiki, W.A.; Ribeiro, V.P.B.; Gusman, L.; Coura Filho, G.B.; Sapienza, M.T.; Ono, C.R; Watanabe, T.; Costa, P.L.A.; Hironaka, F.; Cerri, G.G.; Buchpiguel, C.A. [Universidade de Sao Paulo (FMUSP), SP (Brazil). Fac. de Medicina. Hospital das Clinicas

    2008-07-01

    Full text: Introduction: Hepatic hydrothorax is a significant pleural effusion, greater than 500 mL, that appears as a clinical manifestation of portal hypertension in patients with advanced cirrhosis, in the absence of cardiopulmonary disease. Its mechanisms may be explained by migration of ascitic fluid through diaphragm defects. Radioisotope scintigraphy may contribute for the diagnostic of hepatic hydrothorax. Case report: Female, 79 years old, with a history of hepatic cirrhosis due to hepatitis B virus, without primary pulmonary or heart disease. She presented worsening of clinical ascites and dyspnoea, and it was diagnosed an extensive right pleural effusion. She underwent a thoracocentesis with a drainage of 2000 mL of light yellow-citrine fluid with transudate features. The pleural effusion quickly relapsed, leading the hypothesis of a hepatic hydrothorax. A scintigraphy was requested to assess peritoneo-pleural shunt. A dose of 370 MBq (10 mCi) of {sup 99m}Tc sulfur colloid was instilled intraperitoneally. Static images involving the thorax and upper abdomen were acquired at 10, 20, 30 and 40 minutes and 4 hours after injection. At 10 minutes the radiotracer was seen on the left side of the thoracic region. The scintigraphy was repeated three days later, just after new thoracocentesis, due to the tracer progression to the left side of the thorax differed to the location of pleural effusion. Likewise, until 4 hours of the second study, the radiotracer was seen again on the left side of the thorax. However, a delayed image of 24 showed accumulation of the radiotracer in the right pleural cavity, confirming peritoneo-pleural shunt as cause of pleural effusion in this patient. Discussion: Hydrothorax is an uncommon complication in patients with decompensated hepatic cirrhosis. Its mechanisms are still not well elucidated, however, it is known that presence of defects in the diaphragm associated with the imbalance of ascitic fluid volume and the pleural

  1. Unusual and subtle scintigraphic findings in the evaluation of the battered child

    International Nuclear Information System (INIS)

    Howard, J.L.; Barron, B.J.; Smith, G.G.

    1988-01-01

    Nuclear medicine imaging plays a key role in the evaluation of skeletal trauma. Recent findings in our department show that diagnoses other than skeletal trauma are often identified by means of subtle and unusual scintigraphic findings. The subject material will place strong emphasis on the less mentioned but often more important visceral and intracranial injury. Specific scintigraphic abnormalities to be demonstrated, with appropriate correlative radiographs, include (1) visceral and soft tissue (eg, duodenal hematoma, splenic laceration, renal contusion, hepatic hematoma, rhabdomyolysis and soft-tissue hematoma); (2) cranial (eg, intracranial bleeding, edema, and infarct, cephalohematoma, skull fracture, and widening of sutures; and (3) skeletal (various subtle abnormalities)

  2. A long-acting calcium antagonist over one year did not improve BMIPP myocardial scintigraphic imagings in patients with pure coronary spastic angina

    International Nuclear Information System (INIS)

    Sueda, Shozo; Oshita, Akira; Izoe, Yousuke; Kohno, Hiroaki; Fukuda, Hiroshi; Ochi, Takaaki; Uraoka, Tadao

    2007-01-01

    Calcium antagonists (Ca) have been effective in reducing angina attacks in patients with variant angina. However, there are no reports regarding the effectiveness of Ca on myocardial fatty acid metabolic images in patients with pure coronary spastic angina (CSA). This study sought to examine the correlation between myocardial fatty acid metabolic images and the medical treatment of Ca in patients with pure CSA. This study included 35 consecutive patients (28 men, mean age of 66±10 years) with angiographically confirmed coronary spasm and no fixed stenosis. Long-acting Ca was administered to all 35 patients. Isosorbide dinitrate/nicorandil/another Ca/beta-blocker were administered when chest pain was not controlled. Using an iodinated fatty acid analogue, 15-(p-[iodine-123]iodophenyl)-3-(R,S)methylpentadecanoic acid (BMIPP), myocardial scintigraphies with intravenous adenosine triphosphate infusion were performed before cardiac catheterization and 12 mo after medical therapy. According to the medical control states, these 35 patients were classified into 3 groups; response (disappearance of angina attacks, 12 pts, 60±11 years), partial response (angina attacks <4/mo, 12 pts, 67±10 years), and no response to therapy (angina attacks ≥4/mo, 11 pts, 71±6 years). Reduced BMIPP uptake was observed in 24 (69%) of 35 patients before the treatment. Reduced BMIPP uptake was also found in 18 patients (51%) after 12 mo. Normal BMIPP uptake after 12 mo therapy was observed in about half (response: 42%, partial response: 58%, no response: 45%) of patients among the 3 groups. There was no difference regarding the value of washout rate (WOR) (response; 10±7 (before), 14±8% (12 mo)), partial response; 11±7, 10±5%, no response; 13±9, 14±8%) among the 3 groups. The defect scores of BMIPP in the three groups were not different during at least one year medical therapy. No difference regarding the distribution of other medical therapies (angiotensin converting enzyme

  3. Technetium-99m-Labeled Sulfadiazine: a Targeting Radiopharmaceutical for Scintigraphic Imaging of Infectious Foci Due To Escherichia coli in Mouse and Rabbit Models.

    Science.gov (United States)

    Ahmed, Muhammad Tauqeer; Naqvi, Syed Ali Raza; Rasheed, Rashid; Zahoor, Ameer Fawad; Usman, Muhammad; Hussain, Zaib

    2017-09-01

    Bacterial infection is one of the vital reasons of morbidity and mortality, especially in developing countries. It appears silently without bothering the geological borders and imposes a grave threat to humanity. Nuclear medicine technique has an important role in helping early diagnosis of deep-seated infections. The aim of this study was to develop a new radiopharmaceutical 99m Tc-labeling sulfadiazine as an infection imaging agent. Radiolabeling of sulfadiazine with technetium-99m ( 99m Tc) was carried out using stannous tartrate as a reducing agent in the presence of gentistic acid at pH = 5. The quality control tests revealed ~98% labeling efficiency. Paper chromatographic (PC) and instant thin-layer chromatographic (ITLC) techniques were used to analyze radiochemical yield. Biodistribution and infection specificity of the radiotracer were performed with Escherichia coli (E. coli) infection-induced rats. Scintigraphy and glomerular filtration rate (GFR) study was performed in E. coli-infected rabbits. Scintigraphy indicated E. coli infection targeting potential of 99m Tc-SDZ, while biodistribution study showed minimal uptake of 99m Tc-SDZ in non-targeted tissues. The uptake in the kidneys was found 2.56 ± 0.06, 2.09 ± 0.10, and 1.68 ± 0.09% at 30 min, 1 h, and 4 h, respectively. The infected muscle (target) to non-infected muscle (non-target) ratio (T/NT) was found 4.49 ± 0.04, 6.78 ± 0.07, and 5.59 ± 0.08 at 30 min, 1 h, and 4 h, respectively.

  4. SOLON: An autonomous vehicle mission planner

    Science.gov (United States)

    Dudziak, M. J.

    1987-01-01

    The State-Operator Logic Machine (SOLON) Planner provides an architecture for effective real-time planning and replanning for an autonomous vehicle. The highlights of the system, which distinguish it from other AI-based planners that have been designed previously, are its hybrid application of state-driven control architecture and the use of both schematic representations and logic programming for the management of its knowledge base. SOLON is designed to provide multiple levels of planning for a single autonomous vehicle which is supplied with a skeletal, partially-specified mission plan at the outset of the vehicle's operations. This mission plan consists of a set of objectives, each of which will be decomposable by the planner into tasks. These tasks are themselves comparatively complex sets of actions which are executable by a conventional real-time control system which does not perform planning but which is capable of making adjustments or modifications to the provided tasks according to constraints and tolerances provided by the Planner. The current implementation of the SOLON is in the form of a real-time simulation of the Planner module of an Intelligent Vehicle Controller (IVC) on-board an autonomous underwater vehicle (AUV). The simulation is embedded within a larger simulator environment known as ICDS (Intelligent Controller Development System) operating on a Symbolics 3645/75 computer.

  5. An unusual scintigraphic pattern in sickle cell patients

    International Nuclear Information System (INIS)

    Glaser, A.M.; Chen, D.C.P.; Siegel, M.E.; Norris, S.L.; Haywood, L.J.

    1989-01-01

    We reviewed the nuclear medicine files of all patients enrolled in the sickle cell disease clinic who had had scans performed within the previous 5 years. We specifically looked for patterns of tracer uptake in these scans that would correlate with the severe anemia and consequent bone marrow hyperactivity of sickle cell patients. Thirty-three patients were included (21 men and 12 women) with a mean age of 26.8 years (range 17-48 years). The appearance of each of these patients' most recent scans was examined in the areas of the distal femurs, the proximal tibias and the distal tibias; a distinct triangular shaped pattern of increased activity was identified in these areas in a majority of patients. Thirty-three patients without sickle cell disease served as age-matched controls. This pattern was seen in 65.1% (95 out of 146 images) of the sickle cell patients' delayed images and 80.4% (82 out of 102 images) of their blood pool images. In contrast, the control patients demonstrated the triangular pattern in none of their blood pool studies (0%) and only 10.9% of their delayed bone images (P<0.001). The mean age of sickle cell patients with this pattern is 25.6 years which was significantly lower than that of those without this pattern (mean=37.5 years, P<0.05). Given the high prevalence of this unique scintigraphic pattern in a group of patients with known accelerated bone marrow function, these findings may be scintigraphic evidence of bone marrow expansion. The patient's age appears to be an important factor in visualization of this pattern. (orig.)

  6. Scintigraphic pattern of small bowel bleeding

    International Nuclear Information System (INIS)

    Anshu Rajnish Sharma; Charan, S.; Silva, I.

    2004-01-01

    camera fitted with LEAP collimator. Delayed imaging up to 6 hours was optional and was undertaken only when first 90 minutes images did not reveal any site of bleeding. Two nuclear physicians reviewed the sequential static images for 1) First appearance of focus of activity in a particular quadrant/region of abdomen and 2) looking for its migration pattern. Scintigraphic results were prospectively compared with surgical outcome in 10 patients. Results: Tc-99m RBC Scan localized site of bleeding in 10 of 13 patient evaluated (77%). Ten scan positive patients underwent exploratory laprotomy. On surgical exploration, five culprit lesions were identified in jejunum and as many number of lesions were detected in ileum. Etiological lesions were mainly inflammatory or ulcerative (n=5) followed by neoplastic and vascular ectasias in 2 patients each. One patient showed diverticular disease of jejunum as the source of haemorrhage.Tc-99m RBC Scan was able to distinguish between proximal (jejunal) and distal (ileal) small bowel bleeding in 8 of 10 scan positive cases (80%). Scintigraphy correctly localized bleeding in jejunum and ileum in 3 and 5 patients respectively. In majority of patients (7/10, 70%), scan became positive within 3 hours. Six types of scan patterns were noticed in thirteen patients evaluated with Tc-99m RBCs scan. Five scintigraphic patterns were representative of small bowel bleeding. A serpentine appearance of bowel loops in mid abdomen, focal tracer appearance in right iliac region with subsequent outlining of ascending colon on delayed images, and a focus of activity showing distal extension in circular fashion on sequential static images were characteristic of ileal bleeding. Visualization of fixed loop in left flank region corroborated with jejunal lesion (Leiomyoma) in our series. An abnormal blush and early localization of diffuse activity in left upper quadrant followed by its centripetal extension/movement, was seen in patient with jejunitis

  7. Scintigraphic evaluation of gastrointestinal motility disorders

    Energy Technology Data Exchange (ETDEWEB)

    Choe, Jae Gol [College of Medicine, Korea Univ., Seoul (Korea, Republic of)

    2001-02-01

    Current scintigraphic tests of gastrointestinal motor function provides relevant pathophysiologic information, but their clinical utility is controversial. Many scintigraphic methods are developed to investigate gastrointestinal motility from oral cavity to colon. These are esophageal transit scintigraphy, oropharyngeal transit study, gastric emptying test, small bowel transit time measurement, colon transit study and gastroesopahgeal reflux scintigraphy. Scintigraphy of gastrointestinal tract is the most physiologic and noninvasive method to evaluate gastrointestinal motility disorders. Stomach emptying test is regarded as a gold standard in motility study. Gastrointestinal transit scintigraphy also has a certain role in assessment of drug effect to GI motility and changes after theraphy of motility disorders. Scintigraphy provides noninvasive and quantitative assessment of physiological transit throughout the gastrointestinal tract, and it is extremely useful for diagnosing gastrointestinal motor dysfunction. This article reviews the current procedures, indications, significance and guidelines for gastrointestinal motility measurements by scintigraphy.

  8. Scintigraphic evaluation of gastrointestinal motility disorders

    International Nuclear Information System (INIS)

    Choe, Jae Gol

    2001-01-01

    Current scintigraphic tests of gastrointestinal motor function provides relevant pathophysiologic information, but their clinical utility is controversial. Many scintigraphic methods are developed to investigate gastrointestinal motility from oral cavity to colon. These are esophageal transit scintigraphy, oropharyngeal transit study, gastric emptying test, small bowel transit time measurement, colon transit study and gastroesopahgeal reflux scintigraphy. Scintigraphy of gastrointestinal tract is the most physiologic and noninvasive method to evaluate gastrointestinal motility disorders. Stomach emptying test is regarded as a gold standard in motility study. Gastrointestinal transit scintigraphy also has a certain role in assessment of drug effect to GI motility and changes after theraphy of motility disorders. Scintigraphy provides noninvasive and quantitative assessment of physiological transit throughout the gastrointestinal tract, and it is extremely useful for diagnosing gastrointestinal motor dysfunction. This article reviews the current procedures, indications, significance and guidelines for gastrointestinal motility measurements by scintigraphy

  9. Scintigraphic presentation of hip joint synovial chondromatosis

    Energy Technology Data Exchange (ETDEWEB)

    Zwas, S T; Friedman, B; Nerubay, J

    1988-09-01

    A case of hip joint synovial chondromatosis with an unusual scintigraphic pattern is described. This pattern was suggestive of a hip joint destructive reactive articular process or late manifestations of avascular necrosis of the femoral head. Concurrent radiographs were normal, as were laboratory investigations. Follow-up radiographs six months later showed radiolucencies and erosive bone changes in the diseased joint. Surgical and histopathological findings revealed well developed hip synovial chondromatosis (HSC) with thickened synovium and large, loose, cartilaginous bodies occupying and widening the tightened joint space, with destructive secondary juxta articular pressure and bone erosions. This and other scintigraphic patterns in HSC, and the differential diagnosis of the findings in patients with painful hip presentations are discussed.

  10. Scintigraphic examinations concerning back pain

    International Nuclear Information System (INIS)

    Mueller-Brand, J.

    1983-01-01

    Radinuclide skeletal scintigraphy is recognized as a screening method for patients with back pain. The analog scintigram is a functional image with high sensitivity and low specificity. The improvement in specificity can be achieved using computer procedures as digital imaging, smoothing, contrast enhancement and profile selection to quantitate certain properties of the scan. Three-phase-skeletal scintigraphy, 67-Ga-citrate or 111-In labeled leucocytes augement the specificity, too. (orig.)

  11. The scintigraphic reaction pattern of traumatic bone lesions

    International Nuclear Information System (INIS)

    Spitz, J.

    1994-01-01

    The indications for bone scintigraphy in traumatology result: 1. Definite exclusion of bone lesions by normal scintigraphic findings (except for the scull). 2. Unclear result of X-ray or a mismatch between clinical investigation and X-ray result. 3. Screening after multiple injury which leads to the detection of an unknown bone lesion in every second patient. 4. Suspicion of a complicated healting course in cases of doubtful X-ray results. 5. The estimation of relative fracture age. This question always rises, if a pre-existing trauma or morphologic changes in X-ray make a clear diagnosis impossible. The additional information gained by bone scintigraphy is in part exclusive and not to be drawn from any other imaging modality. This renders bone scintigraphy to an important tool in the work up of medico-legal questions in traumatology. (orig.) [de

  12. Clinical, radiographic and scintigraphic aspects of the trapeziometacarpal osteoarthritis

    International Nuclear Information System (INIS)

    Kaziyama, Helena Hideko Seguchi

    1996-01-01

    Trapeziometacarpal osteoarthritis occurs mainly in women during the menopausal period. It is related to manual activities and is usually bilateral. The onset is insidious and the evolution is slow and progressive. It is characterized by of strength and pain in the basis of the thumb resulting in limitation of the use and function of the hand. The diagnosis of this condition is based on the physical examination. The manouver of compression axial-rotation of the trapezimetacarpal joint is a common positive finding. Typical findings of osteoarthritis are present in the radiological studies. Scintigraphic images have a predictive value. The early diagnosis is important to avoid the risk factors and to prevent disabilities of the hand. (author)

  13. Importance of methodology on (99m)technetium dimercapto-succinic acid scintigraphic image quality: imaging pilot study for RIVUR (Randomized Intervention for Children With Vesicoureteral Reflux) multicenter investigation.

    Science.gov (United States)

    Ziessman, Harvey A; Majd, Massoud

    2009-07-01

    We reviewed our experience with (99m)technetium dimercapto-succinic acid scintigraphy obtained during an imaging pilot study for a multicenter investigation (Randomized Intervention for Children With Vesicoureteral Reflux) of the effectiveness of daily antimicrobial prophylaxis for preventing recurrent urinary tract infection and renal scarring. We analyzed imaging methodology and its relation to diagnostic image quality. (99m)Technetium dimercapto-succinic acid imaging guidelines were provided to participating sites. High-resolution planar imaging with parallel hole or pinhole collimation was required. Two core reviewers evaluated all submitted images. Analysis included appropriate views, presence or lack of patient motion, adequate magnification, sufficient counts and diagnostic image quality. Inter-reader agreement was evaluated. We evaluated 70, (99m)technetium dimercapto-succinic acid studies from 14 institutions. Variability was noted in methodology and image quality. Correlation (r value) between dose administered and patient age was 0.780. For parallel hole collimator imaging good correlation was noted between activity administered and counts (r = 0.800). For pinhole imaging the correlation was poor (r = 0.110). A total of 10 studies (17%) were rejected for quality issues of motion, kidney overlap, inadequate magnification, inadequate counts and poor quality images. The submitting institution was informed and provided with recommendations for improving quality, and resubmission of another study was required. Only 4 studies (6%) were judged differently by the 2 reviewers, and the differences were minor. Methodology and image quality for (99m)technetium dimercapto-succinic acid scintigraphy varied more than expected between institutions. The most common reason for poor image quality was inadequate count acquisition with insufficient attention to the tradeoff between administered dose, length of image acquisition, start time of imaging and resulting image

  14. Navy Operational Planner - Undersea Warfare Module

    Science.gov (United States)

    2016-09-01

    concepts are considered in NOP–USW that are not in previous research: time phasing of missions, mutually exclusive missions, and asset availability...operational planning efforts. NOP–USW suggests the correct allocation of assets across a wide theater of operation to accomplish missions in the...Master’s thesis 4. TITLE AND SUBTITLE NAVY OPERATIONAL PLANNER – UNDERSEA WARFARE MODULE 5. FUNDING NUMBERS 6. AUTHOR(S) Guy A. Molina 7

  15. Pharyngeal transit time measured by scintigraphic and biomagnetic method

    International Nuclear Information System (INIS)

    Miquelin, C.A.; Braga, F.J.H.N.; Baffa, O.

    1996-01-01

    A comparative evaluation between scintigraphic and biomagnetic method to measure the pharyngeal transit is presented. Three volunteers have been studied. The aliment (yogurt) was labeled with 9 9 m Technetium for the scintigraphic test and with ferrite for the biomagnetic one. The preliminary results indicate a difference between the values obtained, probably due to the biomagnetic detector resolution

  16. Scintigraphic assessment of gastrointestinal motility

    DEFF Research Database (Denmark)

    Madsen, Jan Lysgård

    2014-01-01

    intestinal and colonic transit. This article reviews current imaging techniques, methods for data processing and principles for evaluating results when scintigraphy is used to assess gastrointestinal motility. Furthermore, clinical indications for performing scintigraphy are reviewed.......Gastrointestinal transit reflects overall gastrointestinal motor activity and is regulated by a complex interplay between neural and hormonal stimuli. Thus, transit measurements provide a measure of the combined effects of gastrointestinal muscular activity and feedback from the gut and brain....... Dysmotility in the different major segments of the gastrointestinal tract may give rise to similar symptoms; hence, localizing transit abnormalities to a specific segment is a valuable element of diagnostic evaluation. Scintigraphy is an effective noninvasive tool to assess gastric emptying as well as small...

  17. Scintigraphic measurement of colonic transit in patients with idiopathic constipation

    International Nuclear Information System (INIS)

    Yoon, K. H.; Kim, C. K.

    1999-01-01

    To evaluate usefulness of scintigraphic measurement of total and regional colonic transit in patients with idiopathic constipation. 25 patients who were complained chronic constipation underwent scintigraphic measurement of the total and regional colon transit. Of them 10 patients were diagnosed as idiopathic constipation, none of whom had evidence of abnormal function of the pelvic floor. Ten healthy volunteers were also studied. 67 Gallium-labelled Amberlite resin particles were ingested in a coated capsule with methacrylate that dispersed in the ileocecal region. Images were obtained using a gamma camera at regular intervals for the 2, 4, 8, 24, and 48 hours after the initial counting of the radioactivity in the cecum. We determined the geometric center in four regions of interest in the colon (ascending, transverse, descending, and rectosigmoid). Ten patients with colonic inertia showed significant retention of solid residue in the ascending and transverse colon over a 48-hour period. The median values for the healthy subjects at 2, 4, 8, and 24, and 48 hours were 1.44±0.2 (midway through ascending), 1.71±0.45 (midway through transverse), 2.64±0.95 (midway through descending), 3.94±0.89 (midway through rectosigmoid), and 4.52±0.76 (midway through the stool compartment). On the contrary, the values of ten patients with colonic inertia were 1.0±0.0 (midway through ascending), 1.0±0.0 (midway through ascending). 1.02 ±0.06 (midway through ascending), 1.70±0.36 (midway through transverse), and 2.33±0.31(midway through descending) at the same time (p<0.001). In patients with idiopathic constipation is characterized by exaggerated reservoir factions of the ascending and transverse colons. Scintigraphy using 67 Gallium-labelled pellets seems to be a useful tool to demonstrate the delayed colonic transit in patients with colonic inertia

  18. Scintigraphic visualization of bacterial translocation in experimental strangulated intestinal obstruction

    International Nuclear Information System (INIS)

    Galeev, Yu.M.; Popov, M.V.; Salato, O.V.; Lishmanov, Yu.B.; Grigorev, E.G.; Aparcin, K.A.

    2009-01-01

    The purpose of this study was to obtain scintigraphic images depicting translocation of 99m Tc-labelled Escherichia coli bacteria through the intestinal barrier and to quantify this process using methods of nuclear medicine. Thirty male Wistar rats (including 20 rats with modelled strangulated intestinal obstruction and 10 healthy rats) were used for bacterial scintigraphy. 99m Tc-labelled E. coli bacteria ( 99m Ts-E. coli) with an activity of 7.4-11.1 MBq were administered into a section of the small intestine. Scintigraphic visualization of bacterial translocation into organs and tissues of laboratory animals was recorded in dynamic (240 min) and static (15 min) modes. The number of labelled bacteria, which migrated through the intestinal barrier, was quantified by calculating the translocation index (TI). Control indicated no translocation of 99m Ts-E. coli administered into the intestine through the parietes of the small intestine's distal part in healthy animals. Animals with strangulated obstruction demonstrated different migration strength and routes of labelled bacteria from strangulated and superior to strangulation sections of the small intestine. 99m Ts-E. coli migrated from the strangulated loop into the peritoneal cavity later causing systemic bacteraemia through peritoneal resorption. The section of the small intestine, which was superior to the strangulation, demonstrated migration of labelled bacteria first into the portal and then into the systemic circulation. The strangulated section of the small intestine was the main source of bacteria dissemination since the number of labelled bacteria, which migrated from this section significantly, exceeded that of the area superior to the strangulation section of the small intestine (p = 0.0003). Bacterial scintigraphy demonstrated the possibility of visualizing migration routes of labelled bacteria and quantifying their translocation through the intestinal barrier. This approach to study bacterial

  19. Scintigraphic measurement of colonic transit in patients with idiopathic constipation

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, K. H.; Kim, C. K. [College of Medicine, Wonkwang Univ., Iksan (Korea, Republic of)

    1999-07-01

    To evaluate usefulness of scintigraphic measurement of total and regional colonic transit in patients with idiopathic constipation. 25 patients who were complained chronic constipation underwent scintigraphic measurement of the total and regional colon transit. Of them 10 patients were diagnosed as idiopathic constipation, none of whom had evidence of abnormal function of the pelvic floor. Ten healthy volunteers were also studied. 67 Gallium-labelled Amberlite resin particles were ingested in a coated capsule with methacrylate that dispersed in the ileocecal region. Images were obtained using a gamma camera at regular intervals for the 2, 4, 8, 24, and 48 hours after the initial counting of the radioactivity in the cecum. We determined the geometric center in four regions of interest in the colon (ascending, transverse, descending, and rectosigmoid). Ten patients with colonic inertia showed significant retention of solid residue in the ascending and transverse colon over a 48-hour period. The median values for the healthy subjects at 2, 4, 8, and 24, and 48 hours were 1.44{+-}0.2 (midway through ascending), 1.71{+-}0.45 (midway through transverse), 2.64{+-}0.95 (midway through descending), 3.94{+-}0.89 (midway through rectosigmoid), and 4.52{+-}0.76 (midway through the stool compartment). On the contrary, the values of ten patients with colonic inertia were 1.0{+-}0.0 (midway through ascending), 1.0{+-}0.0 (midway through ascending). 1.02 {+-}0.06 (midway through ascending), 1.70{+-}0.36 (midway through transverse), and 2.33{+-}0.31(midway through descending) at the same time (p<0.001). In patients with idiopathic constipation is characterized by exaggerated reservoir factions of the ascending and transverse colons. Scintigraphy using 67 Gallium-labelled pellets seems to be a useful tool to demonstrate the delayed colonic transit in patients with colonic inertia.

  20. Dynamic scintigraphic studies after oesophageal reconstruction

    International Nuclear Information System (INIS)

    Maliska, C.M.; Maliska, C.; Pinto, E.; Castro, L.; Fonseca, L.B.E; Miranda, M.

    1997-01-01

    Full text: We have studied the oesophageal transit and gastric emptying in the monitoring of the effect of oesophageal reconstruction surgery. Oncologic patients were evaluated after oesophageal reconstruction surgery with gastric (14 patients) or colonic (5 patients) tube and they were compared with 15 healthy volunteers, using scintigraphic method with liquid food (S-colloid-Tc99m). In the oesophageal transit studies there were no significant statistical differences among the three groups, when we have just considered to two superior (of the three) segments, as oesophagus, showing that the distal neo-tube works just like the stomach of normal volunteers

  1. Serendipity in scintigraphic gastrointestinal bleeding studies

    International Nuclear Information System (INIS)

    Goergen, T.G.

    1983-01-01

    A retrospective review of 80 scintigraphic bleeding studies performed with Tc-99m sulfur colloid or Tc-99m labeled red blood cells showed five cases where there were abnormal findings not related to bleeding. In some cases, the abnormalities were initially confused with bleeding or could obscure an area of bleeding, while in other cases, the abnormalities represented additional clinical information. These included bone marrow replacement related to tumor and radiation therapy, hyperemia related to a uterine leiomyoma and a diverticular abscess, and a dilated abdominal aorta (aneurysm). Recognition of such abnormalities should prevent an erroneous diagnosis and the additional information may be of clinical value

  2. Space Launch System (SLS) Mission Planner's Guide

    Science.gov (United States)

    Smith, David Alan

    2017-01-01

    The purpose of this Space Launch System (SLS) Mission Planner's Guide (MPG) is to provide future payload developers/users with sufficient insight to support preliminary SLS mission planning. Consequently, this SLS MPG is not intended to be a payload requirements document; rather, it organizes and details SLS interfaces/accommodations in a manner similar to that of current Expendable Launch Vehicle (ELV) user guides to support early feasibility assessment. Like ELV Programs, once approved to fly on SLS, specific payload requirements will be defined in unique documentation.

  3. BDI agent architecture for a POMDP planner

    CSIR Research Space (South Africa)

    Rens, G

    2009-06-01

    Full Text Available Planner Gavin Rens1;2 Alexander Ferrein3 Etienne van der Poel1 1 School of Computing, Unisa, Pretoria, South Africa 2 Knowledge Systems Group, Meraka Institute, CSIR, Pretoria, South Africa 3 Robotics and Agents Research Laboratory, University... into the situation calculus has previously been done (e.g., (Bacchus, Halpern, and Levesque 1999)) and this work can be used for formulating POMDPs. Further, given a background action theory, an initial state and a goal state (or reward function in POMDPs), Golog...

  4. Scintigraphic assessment of Barrett's esophagus

    International Nuclear Information System (INIS)

    Kotler, J.A.; Sampliner, R.E.; Kogan, F.J.; Henry, R.E.; Mason, B.F.

    1984-01-01

    Barrett's (B) esophagus is defined by the presence of columnar epithelium above the gastroesophageal junction. Patients with 5cm histologically proven B were evaluated for mucosal labeling (ML), esophageal motility (EM), gastroesophageal reflux (GER), and gastric emptying (GE) of solids and liquids with and without iv metaclopramide (MCP). ML, after premedication with cimetidine, was evaluated 20 and 40 min after injection of Tc-99m04 with ANT and RAO views. Eight of 11 B and 0 of 2 controls (C) labeled esophageal mucosa. EM was assessed in the supine position over one min after a 15 ml swallow Tc-99mSc-H2O. The normal pattern shows sequential, aboral, discreet peaks with no retrograde movement over one min in three computer derived regions over the esophagus. Five of 16 B and 1 of 6 C demonstrated abnormal pattern. GER was assessed in the supine position by serially increasing extrinsic binder pressures from 0 to 100 Torr after ingestion of 300 ml of Tc-99mSc-orange juice (OJ). GER was present in 13 of 15 B and 0 of 11 C. Reflux ranged from 5.1% to 30% at 100 Torr. Hiatal hernia (HH) was identified in 14 of 16 B by endoscopy and in 10 of 16 by scintigraphy. GE was evaluated after a liquid meal of 300 ml Tc-99mSc-OJ and a solid meal of Tc-99mSc-egg salad sandwich. The supine subject was imaged anteriorly for 30 min (liquid) or 60 min (solid). GE was assessed an additional 10 min after MCP. Clearance time (50%) for solid Ge was calculated from extrapolated linear fits of decay corrected data. There was no significant difference in liquid or solid GE between B and C. The authors conclude the following: 1) ML detects B with lower sensitivity than previously reported; 2) EM disorders are frequently found in B; 3) GER is frequently identified in B; 4) HH can be identified by nuclear technique; and 5) B shows normal GE and responds to MCP

  5. Experience based on 60 observations of scintigraphic bone exploration using pyrophosphates

    International Nuclear Information System (INIS)

    Mienville, J.-C.

    1975-01-01

    5 to 15 millicuries of technetium 99m-labelled pyrophosphates are injected intraveinously. 3 to 5 hours later, when the blood activity has dropped, the bone uptake is sufficient to give a good scintigraphic image of the skeleton. The skeleton may be explored one segment at a time, using a scanning scintigraph or a scintillation camera, or the whole skeleton front and back may be examined much more quickly with a 'whole-body' device. A study of 60 observations shows the large number of hyperfixations revealed by isotopic explorations in rheumatological diseases. A hyperfixation was observed in almost all bone localities of osteophilic cancers, osteonecrosis, Paget's disease, infections osteo-arthritis and algoneurodystrophy. On the other hand the isotopic test was found to be negative or inefficient in arthroses, osteoporosis and local bone manifestations of Kahler's or Hodgkin's disease. Finally inflammatory arthritis was detectable by scintigraphy in about half the cases studied. In reality a hyperfixation reflects a local rise in the metabolic activity of the bone at the moment of the examination. As a result the scintigraphic images lack specificity. This factor must therefore be accounted for in the patient's records and isotopic results compared with those of clinical and para-clinical examinations [fr

  6. Scintigraphic detection of thrombi using indium-111-labeled autologous platelets

    International Nuclear Information System (INIS)

    Ikeoka, Kiyomitsu; Todo, Yasuhiro; Konishiike, Atsushi; Fujisue, Ryu; Ohyanagi, Mitsumasa; Yasutomi, Nagao; Tanimoto, Masaho; Kawai, Yoshitaka; Iwasaki, Tadaaki

    1985-01-01

    Intracardiac and arterial thrombi were examined by scintigraphy using In-111-oxine labeled autologous platelets. 1. In 22 cases of myocardial infarction including six with ventricular aneurysms, four had positive findings of thrombi on imaging and detected also by echocardiography. All four had ventricular aneurysms. The so-called ''moya-moya'' echoes (fuzzy echoes) were demonstrated in two of these four cases. 2. We encountered two cases with positive findings on imaging in 13 with mitral valve disease. These two had systemic embolic episodes after scintigraphic examination. ''Moya-moya'' echoes were detected in the left atrial cavity in four with negative findings on imaging. 3. Positive images were obtained in two of three with acute arterial occlusive disease, and in both cases platelet deposition was observed in the proximal site of obstruction. Though thrombectomy was performed for one of these two cases, no thrombus was detected at the site of platelet deposition. After one month, re-examination revealed only negative findings in all sites in both these patients. 4. In the six cases of aortic aneurysm, three had platelet deposition within their aneurysms, and surgery was performed for these positive cases, but one of them had no thrombus. 5. Positive images were obtained in only one of seven patients with chronic arterial occlusive disease. 6. Coagulation tests and platelet studies were investigated for patients with positive or negative platelet scans. Only the data of the thrombo-test showed a significant difference (97 +- 9 % vs 23 +- 7 %, p < 0.001). Three cases of positive imaging became negative after anticoagulant therapy. 7. We tried ECT for eight cases 24 hours after injection of In-111-oxine labeled platelets. Three cases showed clear images of thrombi, while the planar images could not detect them at an early stage. Therefore, we propose that ECT can be a useful technique for diagnosing intracardiac thrombi in early stage. (author)

  7. Embedding Communication Skills for Future Financial Planners

    Directory of Open Access Journals (Sweden)

    L. Celeste Rossetto

    2010-12-01

    Full Text Available Financial planners need to have solid knowledge of a range of financial concepts and be adeptcommunicators. Australian universities comprehensively ground students in the necessary contentknowledge for their future careers, however, scant attention is paid to the indispensable communication skillsthat students will need when they enter the professional arena. Students need to accumulate financialplanning knowledge but they also have to interact with clients and peers in a business where they willnegotiate a professional identity for themselves that will serve their specific expertise. It takes time to developthese skills and to assume a professional identity. The focus of our paper is how to engender this persona atthe same time as the students acquire their knowledge. We focus on strategies and activities that were used toembed professional communication skills within a financial planning subject in a regional university throughexperiential learning and authentic tasks.

  8. Model Checking the Remote Agent Planner

    Science.gov (United States)

    Khatib, Lina; Muscettola, Nicola; Havelund, Klaus; Norvig, Peter (Technical Monitor)

    2001-01-01

    This work tackles the problem of using Model Checking for the purpose of verifying the HSTS (Scheduling Testbed System) planning system. HSTS is the planner and scheduler of the remote agent autonomous control system deployed in Deep Space One (DS1). Model Checking allows for the verification of domain models as well as planning entries. We have chosen the real-time model checker UPPAAL for this work. We start by motivating our work in the introduction. Then we give a brief description of HSTS and UPPAAL. After that, we give a sketch for the mapping of HSTS models into UPPAAL and we present samples of plan model properties one may want to verify.

  9. Urban Planners with Renewable Energy Skills

    Directory of Open Access Journals (Sweden)

    Arto Emerik Nuorkivi

    2013-06-01

    Full Text Available There is no much tradition to combine urban and energy planning together to fight Climate Change even though energy production with fossil fuels is the main cause to the Change. Pilot training of urban planners in five EU countries such Finland, Germany, Hungary, Spain and the United Kingdom to understand the basics of renewable energy sources (RES and energy efficiency (EE has been carried out during 2011-2012 under co-financing of Intelligent Energy Europe. Organizing such pilot training was challenging for many reasons, but the outcome can be consdered highly statisfactory, based on the recorded feedback of trainees and other stakeholders. The project encourages other planning schools in Europe to learn from the experience and to use the published training materials available in ten languages in their curricula.

  10. Computer processing of dynamic scintigraphic studies

    International Nuclear Information System (INIS)

    Ullmann, V.

    1985-01-01

    The methods are discussed of the computer processing of dynamic scintigraphic studies which were developed, studied or implemented by the authors within research task no. 30-02-03 in nuclear medicine within the five year plan 1981 to 85. This was mainly the method of computer processing radionuclide angiography, phase radioventriculography, regional lung ventilation, dynamic sequential scintigraphy of kidneys and radionuclide uroflowmetry. The problems are discussed of the automatic definition of fields of interest, the methodology of absolute volumes of the heart chamber in radionuclide cardiology, the design and uses are described of the multipurpose dynamic phantom of heart activity for radionuclide angiocardiography and ventriculography developed within the said research task. All methods are documented with many figures showing typical clinical (normal and pathological) and phantom measurements. (V.U.)

  11. The scintigraphic investigation of sacroiliac disease.

    Science.gov (United States)

    Lentle, B C; Russell, A S; Percy, J S; Jackson, F I

    1977-06-01

    Bone scintigraphs obtained with both Technetium-99m polyphosphate and Technetium-99m pyrophosphate have been abnormal at the sacroiliac joints of 44 patients with definite ankylosing spondylitis (AS). Because of the normal registration of the sacroiliac joints on bone scintigraphy, it has been necessary to develop a profile-scan technique to quantify the abnormality that proves to be significantly different from the normal finding. In 17 patients with a strong clinical suspicion of AS but normal radiographs, the sacroiliac joints have frequently been abnormal. This finding is meaningful because there is a common occurence in this group of the histocompatibility antigen HL A-B27, known to be a marker of AS. We also note the frequency of abnormal sacroiliac scinitigrams in 26 patients with rheumatoid arthritis and in a group of other diseases-Crohn's disease, uveitis, psoriasis, ulcerative colitis, and Reiter's disease-all of which share some of the manifestations of AS.

  12. Avascularity of the femoral head following intracapsular fracture: a comparative scintigraphic and bioptic study

    Energy Technology Data Exchange (ETDEWEB)

    Hoilund-Carlsen, P F; Widding, A; Uhrenholdt, A; Christoffersen, P; Grieff, J [Copenhagen Univ. (Denmark)

    1980-03-01

    Bioptic and scintigraphic methods of diagnosing avascular necrosis of the femoral head following intracapsular fracture of the femoral neck were compared. During operative treatment of patients, biospy samples of bone marrow were taken from the femoral head about 2 hours after the intravenous injection of sup(99m)Tc-Sn-pyrophosphate; histological examination of the biopsies were also performed. Scintigrams of the femoral head using sup(99m)Tc-pyrophosphate were performed 2 days, 7 days and 6 weeks post-operatively. The biopsies confirmed no morphological changes being apparent in the first few days. The biopsy samples indicated two groups of patients with either high or low activity in the femoral head. However, it was concluded that the use of bone-seeking radionuclides with this technique might be more reliable. Scintigraphic trends divided the patients into three groups, one with persistently normal, another with varying, and a third with decreased activity in the femoral head. It was concluded that very early scintigraphy is probably not the method of choice since the images were often difficult to interpret. For the present, assessment of the viability of the femoral head should rest upon scintigraphic examinations performed about 6 weeks or 3 months after the injury.

  13. Scintigraphic evaluation of traumatic splenic lesions in children

    International Nuclear Information System (INIS)

    Erasmie, U.; Mortensson, W.; Persson, U.; Laennergren, K.; St. Goerans Children's Hospital, Stockholm

    1988-01-01

    Ninety-eight children with recent blunt abdominal trauma which initially evoked clinical suspicion of splenic injury were examined with colloid scintigraphy of the spleen and the liver using multiple imaging views and with abdominal survey. Nineteen children were, in addition, examined with tomographic scintigraphy. The clinical findings and the course of the disorder were reanalysed. Scintigraphy indicated splenic injury in 56 children and hepatic injury in another 5 children. The left lateral and the left oblique were the optimum imaging views for detecting splenic ruptures. Tomographic scintigraphy did not improve the diagnostic yield. Abdominal survey failed to indicate almost every second case of splenic rupture and provided no additional information of significance. The clinical review agreed with the scintigraphic diagnosis of splenic lesions but, in addition, it suggested possible splenic lesions in another 10 children with normal scintigraphy. This discrepancy cannot be explained as surgery was not employed; the occurrence of splenic lesions too small to become detectable at scintigraphy or to provoke clinically evident symptoms may be supposed. (orig.)

  14. Targeting of macrophages for the scintigraphic evaluation of inflammatory lesions in a model of radio-induced inflammation in pigs

    International Nuclear Information System (INIS)

    Hoffschir, D.; Daburon, F.; Normier, G.; Binz, H.; Le Pape, A.

    1991-01-01

    For a new scintigraphic strategy based on the targeting of macrophages recruited by inflammatory lesions, a specific ligand able to interact with these cells both in vitro and in vivo has been developed. J001 is a 34 KDa acylated peptidopoly 1-3 galactoside isolated from proteoglycans of a non pathogenic strain of klebsiella. When labelled with 99mTc then administrated by aerosol, this agent has been demonstrated to be a potent tool for the scintigraphic imaging of inflammatory lymph nodes in experimental berylliosis and in patients with sarcoidosis, lung tumors and ganglionic metastases. An experimental model was developed in pigs using an acute and localized muscular γ irradiation in the limb and skin resection to prevent ulceration. Dynamic imaging was performed during two hours after intravenous injection of 1 mg J001 labelled with 370 MBq 99mTc in the presence of 0.125 mg stannous fluoride. The perfusion of the lesions was evaluated from scintigraphic data obtained both 15 min after IV injection of J001 or 99mTc 04-. The intensity of the fixation of J001 was quantified 2 hours after injection and expressed as a scintigraphic ratio: R2h = cpm in lesion / cpm in a defined healthy area in the same limb. After induction of irradiation, scintigraphic ratios exhibited a progressive increase to reach a maximum (R2h = 3.6) after 3 months. Then, they decreased to recover a normal value about 6 months after irradiation. At that time, histological controls and clinical observations exhibited a significant decrease in inflammatory reaction, macrophages recruitment and apparition of fibrosis. J001 fixation was very sensitive to corticosteroids that resulted in a complete clearing of the scintigraphic images 12 to 24 hours after treatment. Two weeks were then required for a complete recovery of the inflammatory reaction and J001 fixation. So, targeting of macrophages with J001 should offer a sensitive and specific tool for the scintigraphic assessment of inflammation and

  15. The use of 111In-labelled platelets for scintigraphic localization of gastrointestinal bleeding with special reference to occult bleeding

    International Nuclear Information System (INIS)

    Gjerloeff Schmidt, K.; Waever Rasmussen, J.; Grove, O.; Andersen, D.

    1986-01-01

    Gamma-camera imaging of the abdomen after injection of autologous 111 In-labelled platelets was applied for localization of gastrointestinal bleeding in a study of 22 patients. In 15 studies showing scintigraphic signs of bleeding, the clinical presentation included occult bleeding in 6, melaena in 4, and bloody stools in 5 patients. Scintigraphy could be done repeatedly for up to 1 week after a single tracer injection. The time interval between the injection and scintigraphic visualization of bleeding ranged from 10 min to 68 h, being longest in cases of occult bleeding. In most cases the scintigraphic findings were supported by other diagnostic modalities, including surgical removal of presumed sources of bleeding. In seven studies without scintigraphic signs of bleeding, a probable source of bleeding was identified by other means in one patient. The 111 In-platelet method seems to be a promising method for localization of gastrointestinal bleeding which may prove particularly useful in cases of occult or recurrent bleeding

  16. Digital Data Processing of Images

    African Journals Online (AJOL)

    be concerned with the image enhancement of scintigrams. Two applications of image ... obtained from scintigraphic equipment, image enhance- ment by computer was ... used as an example. ..... Using video-tape display, areas of interest are ...

  17. Interest of scintigraphic imaging in Madagascar for the diagnosis of ectopic parathyroid adenoma, about one case; Interet de l'imagerie scintigraphique, a Madagascar, dans le diagnostic de l'adenome parathyroidien ectopique - a propos d'un cas

    Energy Technology Data Exchange (ETDEWEB)

    Andriantsoa, J.; Andriamanalina, T.; Ramamonjy, A.; Ranivontsoarivony, M. [Universite d' Antananarivo, Service de Medecine Nucleaire, Antananarivo(Madagascar); Ramahandridona, G. [CHU d' Antananarivo, Service d' Endocrinologie, Antananarivo (Madagascar); Razafindramboa, H. [Polyclinique d' Ilafy, Service de chirurgie, Antananarivo (Madagascar); Gizy Ratiambahoaka, D. [CHU d' Antananarivo, Service d' Anatomopathologie, Antananarivo (Madagascar)

    2008-11-15

    This study reports the first case of ectopic parathyroid adenoma, diagnosed in the Department of Nuclear Medicine in Antananarivo. This clinical vignette illustrates the interest of the MIBI-Tc-99 m scan in locating this adenoma and its diagnostic confirmation after six years of erratic diagnosis. A whole body bone scintigraphy has also allowed to assess the state of bone metabolism and study outbreaks of fracture. The parathyroid scintigraphy was carried out after intra-venous administration of 666 MBq of MIBI-{sup 99m}Tc. Dynamic images, static early and late static were acquired with a gamma camera E-Cam Siemens. The whole body bone scan was carried out after administration of 555 MBq of M.D.P.-Tc-99 m. The results evidenced the presence of an para-aortic increased uptake area pointing to a left parathyroid adenoma. The persistence of a late left sub maxillary increased uptake area raises, however, a reservation about the existence of a second adenoma. The bone scan displayed global skeletal remodeling, non suggestive of metastases, as it was mentioned with the CT-scan. In a diagnostic tools limited environment, skeletal pain refractory to pain-killers, a chronic hypercalcemia associated with an increased parathyroid hormone level, should trigger the scintigraphic exploration in order to avoid bone and renal complications.

  18. Association of bone scintigraphic abnormalities with knee malalignment and pain.

    Science.gov (United States)

    Kraus, V B; McDaniel, G; Worrell, T W; Feng, S; Vail, T P; Varju, G; Coleman, R E

    2009-11-01

    The information content of knee bone scintigraphy was evaluated, including pattern, localisation and intensity of retention relative to radiographic features of knee osteoarthritis, knee alignment and knee symptoms. A total of 308 knees (159 subjects) with symptomatic and radiographic knee osteoarthritis of at least one knee was assessed by late-phase (99m)Technetium methylene disphosphonate bone scintigraph, fixed-flexion knee radiograph, full limb radiograph for knee alignment and for self-reported knee symptom severity. Generalised linear models were used to control for within-subject correlation of knee data. The compartmental localisation (medial vs lateral) and intensity of knee bone scan retention were associated with the pattern (varus vs valgus) (p<0.001) and severity (p<0.001) of knee malalignment and localisation and severity of radiographic osteoarthritis (p<0.001). Bone scan agent retention in the tibiofemoral, but not patellofemoral, compartment was associated with severity of knee symptoms (p<0.001) and persisted after adjusting for radiographic osteoarthritis (p<0.001). To the authors' knowledge, this is the first study describing a relationship between knee malalignment, joint symptom severity and compartment-specific abnormalities by bone scintigraphy. This work demonstrates that bone scintigraphy is a sensitive and quantitative indicator of symptomatic knee osteoarthritis. Used selectively, bone scintigraphy is a dynamic imaging modality that holds great promise as a clinical trial screening tool and outcome measure.

  19. Signal-shot echo-planner diffusion-weighted MR imaging at 3T and 1.5T for differentiation of benign vertebral fracture edema and tumor infiltration

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hee Jin; Lee, So Yeon; Rho, Myung Ho; Chung, Eun Chul; Kim, Mi Sung; Kwon, Heon Ju; Youn, In Young [Dept. of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2016-09-15

    To compare the apparent diffusion coefficient (ADC) value using single-shot echo-planar imaging sequences at 3T and 1.5T for differentiation of benign fracture edema and tumor infiltration of the vertebral body. A total of 46 spinal examinations were included in the 1.5T MRI group, and a total of 40 spinal examinations were included in the 3T MRI group. The ADC values of the lesion were measured and calculated. The diagnostic performance of the conventional MR image containing sagittal T2-weighted fat saturated image and each diffusion weighted image (DWI) with an ADC value with different b values were evaluated. The mean ADC value of the benign lesions was higher than that of the malignant lesions on 1.5T and 3T (p < 0.05). The sensitivity of the diagnostic performance was higher with an additional DWI in both 1.5T and 3T, but the sensitivities were similar with the addition of b values of 400 and 1000. The specificities of the diagnostic performances did not show significant differences (p value > 0.05). The diagnostic accuracies were higher when either of the DWIs (b values of 400 and 1000) was added to routine MR image for 1.5T and 3T. Statistical differences between 1.5T and 3T or between b values of 400 and 1000 were not seen. The ADC values of the benign lesions were significantly higher than those of the malignant lesions on 1.5T and 3T. There was no statistically significant difference in the diagnostic performances when either of the DWIs (b values of 400 and 1000) was added to the routine MR image for 1.5T and 3T.

  20. Scintigraphic evaluation of Zenker's diverticulum

    Energy Technology Data Exchange (ETDEWEB)

    Valenza, Venanzio; Perotti, Germano; Di Giuda, Daniela [Institute of Nuclear Medicine, Policlinico A. Gemelli, Catholic University of Sacred Heart, Largo Gemelli 8, 00168, Rome (Italy); Castrucci, Gioacchino [Department of Surgery, Bel Colle Hospital, Viterbo (Italy); Celi, Giuseppe; Restaino, Gennaro [Institute of Radiology, Catholic University of Sacred Heart, Rome (Italy)

    2003-12-01

    Zenker's diverticulum (ZD) is a rare pathology, with a prevalence of between 0.01% and 0.11%. Definitive diagnosis of ZD can be accomplished by contrast radiographic examination (barium oesophagogram, BE); oesophageal manometry (ME) is recommended mainly for those patients suffering from dysphagia and/or gastro-oesophageal reflux. The aims of the present study were to assess whether oropharyngo-oesophageal scintigraphy (OPES) is able (a) to visualise ZD and (2) to demonstrate the corresponding alteration in the swallowing phases. We studied 16 patients (nine male, seven female, mean age 67.4 years), and 17 healthy volunteers (ten male, seven female, mean age 53 years) as a control group. All the patients underwent ME, BE and OPES. Nine patients underwent surgery and six of them were re-evaluated after 6 months. We administered 10 ml of water with 37 MBq of technetium-99m colloid through a straw, acquiring 480 sequential images (0.125 s/frame for a total of 60 s) with the patient standing in front of the gamma camera in the 80 right anterior oblique position. Two static images were performed at the end of the dynamic phase, before and after ingestion of 100 ml of unlabelled water to evaluate the presence of inflammation (persistence of radioactivity in the diverticulum or oesophagus). Study of the sequential scintigraphic images and time-activity curves permitted both qualitative (diverticulum visualisation, multiple deglutitions, reflux, presence of inflammation) and quantitative analyses [oral, pharyngeal and oesophageal transit times and retention indexes, tracheal aspiration percentage] of swallowing disorders. OPES showed a good correlation with the results of other diagnostic techniques usually performed in patients with this pathology, and especially with ME in the evaluation of oropharyngeal phase disorders. Furthermore, OPES is a sensitive and simple technique that is well tolerated and entails a low irradiation dose for patients. (orig.)

  1. Analysis of stress fractures associated with lameness in Thoroughbred flat racehorses training on different track surfaces undergoing nuclear scintigraphic examination.

    Science.gov (United States)

    MacKinnon, M C; Bonder, D; Boston, R C; Ross, M W

    2015-05-01

    There is limited information regarding the impact of training track surface on the occurrence of stress fractures. To evaluate the impact of training track surface on the proportion of long bone and pelvic stress fractures associated with lameness in Thoroughbred horses in flat race training undergoing nuclear scintigraphic examination. Retrospective study. Scintigraphic examinations of Thoroughbred flat racehorses were evaluated from 2 hospitals (hospital A [Toronto Equine Hospital], 2003-2009, and hospital B [George D. Widener Hospital for Large Animals, School of Veterinary Medicine, University of Pennsylvania], 1994-2006). Horses admitted to hospital A trained at a single track, at which the main training surface changed from dirt to synthetic on 27 August 2006. Two distinct populations existed at hospital B: horses that trained on dirt (numerous trainers) and those that trained on turf (single trainer). All scintigraphic images were evaluated by a blinded reviewer. Fisher's exact test and logistic regression were used when appropriate, and significance was set at Pfractures detected in scintigraphic examinations from horses training on a synthetic surface (31.7%) in comparison to scintigraphic examinations from horses training on a dirt surface (23.0%) at an earlier point in time (P = 0.03). There was a greater proportion of hindlimb/pelvic and tibial stress fractures diagnosed in horses from the synthetic surface-trained group than from the dirt-trained group at hospital A (Pfractures diagnosed, but other factors, such as training philosophy, appear to be important. Future prospective investigations to fully elucidate the relationship between training track surface and the proportion of stress fractures and other nonfatal musculoskeletal injuries are warranted. © 2014 EVJ Ltd.

  2. Scintigraphical analyses of pulmonary function in dogs

    International Nuclear Information System (INIS)

    Clercx, C.

    1988-01-01

    The main goal of this study was to develop a quantitative analysis from 99mTc aerosol inhalation/perfusion (I/P) lung scintigrams. In particular attention was focused on both the regional I/P distribution, concerning the ratio of the mean I and P values in several lung regions, as well as on the local (intraregional) distribution of I/P, under a wide range of circumstances. In Ch. 2, the method and reference material are described. The distribution of the inhalation-to-perfusion ratios (I/P) is studied in anesthetized healthy dogs, with emphasis on inter-regional distribution and intra-regional dispersion of the I/P ratio. Moreover, it provides an insight into canine pulmonary physiology, frequently transposed from human lung physiology, what is not always correct. Ch. 3 deals with the possible methodological and physiological influences on the interpretation of scintigraphical measurements, such as age, posture and breed. Investigation of the effects of age and breed was pursued using qualitative studies of canine lung surfactant. The actual knowledge in this field lets prospect veterinary clinical meaning in the future. Finally in Ch. 4, the diagnostic value of the measurements was examined in experimental models of important lung disorders with different pathophysiological features, such as lobar and sublobar airway obstruction, and lung embolism. It also permits the investigation of the relative contribution of different compensating mechanisms upon the ventilation-to-perfusion ratio, such as collateral ventilation and hypoxic vasoconstriction. 218 refs.; 31 figs.; 14 tabs

  3. Scintigraphic characteristics of experimental myocardial infarct extension

    International Nuclear Information System (INIS)

    Kronenberg, M.W.; Wooten, N.E.; Friesinger, G.C.; Page, D.L.; Higgins, S.B.; Collins, J.C.; O'Connor, J.L.; Price, R.R.; Brill, A.B.

    1979-01-01

    Technetium-99m-stannous pyrophosphate scintiphotos were evaluated for diagnosing and quantitating myocardial infarct (MI) extension in sedated dogs. Infarction and extension were produced by serial left anterior descending coronary artery ligations at 0 and 48 hours. We compared serial scintiphoto data with regional myocardial blood flow (MBF) (microsphere technique) and infarct histopathology. In eight control dogs, the scintigraphic MI area was stable at 24, 48, and 72 hours. In each of 11 dogs undergoing extension, the MI area increased after the 48-hour occlusion, averaging a 48.9% increase (p < 0.001). Grossly, most extensions were mixtures of confluent necrosis and moderate (patchy) necrosis. MBF to confluent infarct tissue decreased significantly, allowing the documentation of extension by totaling the grams of newly flow-deprived tissue, but patchy infarct tissue had little flow deprivation, making it difficult to quantitate this type of extension accurately by flow criteria alone. Rarely, extension could be diagnosed using conventional histologic criteria. We concluded that the scintiphoto MI area was related quantitatively to infarct weight in both control and extension. However, it was not possible to determine that an increase in the MI scintiphoto area was an accurate predictor of the degree of extension using independent flow or pathologic criteria

  4. Scintigraphic localization of a disseminated malignant pheochromocytoma with the use of 131I-meta-iodobenzylguanidine

    International Nuclear Information System (INIS)

    Troncone, L.; Maini, L.M.; Rufini, V.; Bonifazi, N.; De Rosa, G.; Corsello, S.M.; Mattei, O.

    1984-01-01

    Preliminary clinical studies with 131 I-meta-iodo-benzylguanidine, a newly synthesized radiopharmaceutical and guanethidine analog capable of imaging the adrenal medulla, have led to the identification, of a case of disseminated malignant pheochromocytoma with the localization of brain and bone metastases. The result is of particular interest as the symptomatology in this case appeared rather equivocal and various investigations had led to a completely different diagnosis. This new scintigraphic technique has proved to be safe, specific and noninvasive, and it may have a clinical application as a complementary or alternative technique to conventional diagnostic tests. (orig.)

  5. A comparison of methods of assessment of scintigraphic colon transit.

    Science.gov (United States)

    Freedman, Patricia Noel; Goldberg, Paul A; Fataar, Abdul Basier; Mann, Michael M

    2006-06-01

    There is no standard method of analysis of scintigraphic colonic transit investigation. This study was designed to compare 4 techniques. Sixteen subjects (median age, 37.5 y; range, 21-61 y), who had sustained a spinal cord injury more than a year before the study, were given a pancake labeled with 10-18 MBq of (111)In bound to resin beads to eat. Anterior and posterior images were acquired with a gamma-camera 3 h after the meal and then 3 times a day for the next 4 d. Seven regions of interest, outlining the ascending colon, hepatic flexure, transverse colon, splenic flexure, descending colon, rectosigmoid, and total abdominal activity at each time point, were drawn on the anterior and posterior images. The counts were decay corrected and the geometric mean (GM), for each region, at each time point calculated. The GM was used to calculate the percentage of the initial total abdominal activity in each region, at each time point. Colonic transit was assessed in 4 ways: (a) Three independent nuclear medicine physicians visually assessed transit on the analog images and classified subjects into 5 categories of colonic transit (rapid, intermediate, generalized delay, right-sided delay, or left-sided delay). (b) Parametric images were constructed from the percentage activity in each region at each time point. (c) The arrival and clearance times of the activity in the right and left colon were plotted as time-activity curves. (d) The geometric center of the distribution of the activity was calculated and plotted on a graph versus time. The results of these 4 methods were compared using an agreement matrix. Though simple to perform, the visual assessment was unreliable. The best agreement occurred between the parametric images and the arrival and clearance times of the activity in the right and left colon. The different methods of assessment do not produce uniform results. The best option for evaluating colonic transit appears to be a combination of the analog images

  6. Scintigraphic detection of regional disruption of adrenergic neurons in the heart

    International Nuclear Information System (INIS)

    Sisson, J.C.; Lynch, J.J.; Johnson, J.; Jaques, S. Jr.; Wu, D.; Bolgos, G.; Lucchesi, B.R.; Wieland, D.M.

    1988-01-01

    Experiments were designed to detect regional disruptions of adrenergic neurons in the hearts of living dogs. The neuron disruption was achieved by the application of phenol to the epicardium of the left ventricle. Evidence for denervation was the reduction in endogenous norepinephrine (NE) concentrations in the myocardium beneath the region of phenol treatment and toward the apex. Radiolabeled meta-iodobenzylguanidine (MIBG) acts as an analog of NE and as such is concentrated in adrenergic nerve terminals. Following phenol application, MIBG labeled with 125 I was found, 20 hours after injection, to be distributed within myocardium in patterns comparable to those of NE. However, left stellectomy did not alter the distributions of NE or 125 I-MIBG in the myocardium and apparently did not disrupt adrenergic innervation. MIBG labeled with 123 I enabled scintigraphic images of heart neurons in the living dog 3 and 20 hours after injection; these images portrayed the regions of adrenergic neuron disruption caused by phenol treatment. Concentrations of thallium-201 depicted on scintigraphic image and of triphenyltetrazolium observed on in vitro staining demonstrated no myocardial injury. Thus, scintigraphy with 123 I-MIBG will display regional adrenergic denervations in the heart

  7. Scintigraphic diagnosis of the gastro-esophageal reflux

    Energy Technology Data Exchange (ETDEWEB)

    Pfluecke, F.; Krueger, M.; Reinke, R.; Groth, P. (Rostock Univ. (German Democratic Republic). Radiologische Klinik)

    1982-09-01

    Patients with peptic esophagitis or typical complaints with respect to reflux without esophagitis and control persons (n = 68) were comparatively examined for gastroesophageal reflux by means of scintigraphy (after administration of test solutions labelled with /sup 99m/Tc-DTPA or after intravenous application of /sup 99m/Tc-pertechnetate) and by means of continuous intraesophageal p/sub H/ measurement. The scintigraphic test of the reflux was successful for very few patients only with reflux disease and a reflux detectable by measuring the p/sub H/. The application of pentagastrin failed in improving the scintigraphic detection of the reflux. The cause of the unsuccessful scintigraphic evidence for the majority of the reflux patients seems to be the relatively small reflux volume.

  8. Scintigraphic diagnosis of the gastro-esophageal reflux

    International Nuclear Information System (INIS)

    Pfluecke, F.; Krueger, M.; Reinke, R.; Groth, P.

    1982-01-01

    Patients with peptic esophagitis or typical complaints with respect to reflux without esophagitis and control persons (n = 68) were comparatively examined for gastroesophageal reflux by means of scintigraphy (after administration of test solutions labelled with /sup 99m/Tc-DTPA or after intravenous application of /sup 99m/Tc-pertechnetate) and by means of continuous intraesophageal p/sub H/ measurement. The scintigraphic test of the reflux was successful for very few patients only with reflux disease and a reflux detectable by measuring the p/sub H/. The application of pentagastrin failed in improving the scintigraphic detection of the reflux. The cause of the unsuccessful scintigraphic evidence for the majority of the reflux patients seems to be the relatively small reflux volume

  9. Tokenplan: A Planner for Both Satisfaction and Optimization Problem

    OpenAIRE

    Meiller, Yannick; Fabiani, Patrick

    2001-01-01

    Tokenplan is a planner based on the use of Petri nets. Its main feature is the flexibility it offers in the way it builds the planning graph. The Fifth International Conference on Artificial Intelligence Planning and Scheduling planning competition validated its behavior with a graphplan-like behavior. The next step is to demonstrate the benefits we expect from our planner in planning problems involving optimization and uncertainty handling.

  10. The Toggle Local Planner for sampling-based motion planning

    KAUST Repository

    Denny, Jory

    2012-05-01

    Sampling-based solutions to the motion planning problem, such as the probabilistic roadmap method (PRM), have become commonplace in robotics applications. These solutions are the norm as the dimensionality of the planning space grows, i.e., d > 5. An important primitive of these methods is the local planner, which is used for validation of simple paths between two configurations. The most common is the straight-line local planner which interpolates along the straight line between the two configurations. In this paper, we introduce a new local planner, Toggle Local Planner (Toggle LP), which extends local planning to a two-dimensional subspace of the overall planning space. If no path exists between the two configurations in the subspace, then Toggle LP is guaranteed to correctly return false. Intuitively, more connections could be found by Toggle LP than by the straight-line planner, resulting in better connected roadmaps. As shown in our results, this is the case, and additionally, the extra cost, in terms of time or storage, for Toggle LP is minimal. Additionally, our experimental analysis of the planner shows the benefit for a wide array of robots, with DOF as high as 70. © 2012 IEEE.

  11. Nephrus: expert system model in intelligent multilayers for evaluation of urinary system based on scintigraphic image analysis; Nephrus: modelo de sistema especialista em multicamadas inteligentes para avaliacao do sistema urinario baseado na analise de imagens cintilograficas

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Jorge Wagner Esteves da; Schirru, Roberto [Universidade Federal, Rio de Janeiro, RJ (Brazil). Coordenacao dos Programas de Pos-graduacao de Engenharia. Programa de Engenharia Nuclear; Boasquevisque, Edson Mendes [Hospital dos Servidores do Estado, Rio de Janeiro, RJ (Brazil). Servico de Medicina Nuclear

    1999-11-01

    Renal function can be measured noninvasively with radionuclides in a extremely safe way compared to other diagnosis techniques. Nevertheless, due to the fact that radioactive materials are used in this procedure, it is necessary to maximize its benefits, therefore all efforts are justifiable in the development of data analysis support tools for this diagnosis modality. The objective of this work is to develop a prototype for a system model based on Artificial Intelligence devices able to perform functions related to cintilographic image analysis of the urinary system. Rules used by medical experts in the analysis of images obtained with {sup 99m} Tc+DTPA and /or {sup 99m} Tc+DMSA were modeled and a Neural Network diagnosis technique was implemented. Special attention was given for designing programs user-interface. Human Factor Engineering techniques were taking in account allowing friendliness and robustness. The image segmentation adopts a model based on Ideal ROIs, which represent the normal anatomic concept for urinary system organs. Results obtained using Artificial Neural Networks for qualitative image analysis and knowledge model constructed show the feasibility of Artificial Neural Networks for qualitative image analysis and knowledge model constructed show feasibility of Artificial Intelligence implementation that uses inherent abilities of each technique in the medical diagnosis image analysis. (author) 12 refs., 4 figs., 2 tabs.

  12. Scintigraphic measurement of the contractile activity of the gastric antrum using factor analysis

    International Nuclear Information System (INIS)

    Bergmann, H.; Hoebart, J.; Kugi, A.; Stacher, G.; Granser, G.V.

    1990-01-01

    The motor activity of the gastric antrum is difficult to record by manometric means and scintigraphic methods have proved unsatisfactory so far as no consistent relationship between antral contractile activity and gastric emptying rate could be detected. We investigated, using data recorded in 16 healthy human subjects after the ingestion of a semisolid standard meal, whether a newly developed method employing factor analysis would yield more meaningful and reproducible results. Factor analysis was applied to sequential scintigraphic images (3-s frame time) of gastric antrum. The computed factor images and the respective factor curves are representative of distinct dynamic structures of the antrum. From the more or less sinusoidal excursions of the factor curves, which exhibited the 3 cycles per minute frequency characteristic for the stomach, amplitude, frequency and propagation velocity of antral contractions can be calculated. The amplitudes of the factor curves were used to calculate a contraction index. This contraction index was found to be correlated significantly negatively with the gastric half-emptying time of the ingested meal. The employed factor analytical approach thus seems a promising tool to further investigate the role of antral contractility in the process of gastric emptying. (Authors)

  13. Quantitative and regional evaluation methods for lung scintigraphs

    International Nuclear Information System (INIS)

    Fichter, J.

    1982-01-01

    For the evaluation of perfusion lung scintigraphs with regard to the quantitative valuation and also with regard to the choice of the regions new criteria were presented. In addition to the usual methods of sectioning each lung lobe into upper, middle and lower level and the determination of the per cent activity share of the total activity the following values were established: the median of the activity distribution and the differences of the per cent counting rate as well as of the median of the corresponding regions of the right and left lung. The individual regions should describe the functional structures (lobe and segment structure). A corresponding computer program takes over the projection of lobe and segment regions in a simplified form onto the scintigraph with consideration of individual lung stretching. With the help of a clinical study on 60 patients and 18 control persons with 99mTc-MAA and 133 Xe-gas lung scintigraphs the following results could be determined: depending on the combination of the 32 parameters available for evaluation and the choice of regions between 4 and 20 of the 60 patients were falsely negatively classified and 1 to 2 of the 18 controls were falsely positive. The accuracy of the Tc-scintigraph proved to be better. All together using the best possible parameter combinations comparative results were attained. (TRV) [de

  14. Scintigraphic evaluation of the sacroiliac joints in anklylosing spondylitis

    International Nuclear Information System (INIS)

    Schoerner, W.

    1980-01-01

    The sedimentation of sup(99m)Tc-phosphate complexes into the sacroiliac joints was investigated in 94 patients with loin pains and suspected of ankylosing spondylitis (SpA) and a control group of 96 healthy patients. The investigation yields the following results: 1. the visual evaluation of the scintigrams does not allow a reliable diagnosis and should be replaced by a semi-quantitative technique, 2. the index ISC/sacrum does remarkably depend on age, 3rd even in young patients the scintigraphic examination appears to be useful to alidate the clinical suspicion of sacroilictis which is in contradiction to literature, 4th with increasing SpA the scintigraphic detectability of changes in the ISG decreases. 5th the floriditily of the ISG process determines the scintigraphic detectability of the process of the disease, 6th the scintigraphic finding is unspecific. Inflammatory states of the disease of different genesis and degenerative processes in the ISG equally yield pathological index values. (orig./MG) [de

  15. Scintigraphic evidence of transplanted hepatocytes in spleen and liver

    International Nuclear Information System (INIS)

    Henne-Bruns, D.; Kremer, B.; Gramminger, K.; Broelsch, C.

    1986-01-01

    In rats suffering from hepatic enzymatic deficiency transplanted hepatocytes could be evidenced scintigraphically in liver, spleen and granulomas. In pigs, however, it is very difficult to demonstrate transplanted hepatocytes by scintiscanning because of the thickness of the tissues and the high background radiation in large animals

  16. Scintigraphic analysis of thyroid diseases at the Lagos University ...

    African Journals Online (AJOL)

    This paper presents a retrospective analysis of randomly selected clinical scintigraphic records at the College of Medicine/Lagos University Teaching Hospital, Nigeria. Out of the 436 patients scanned for various thyroid abnormalities, 266 (61.0%) were used for the analysis due to insufficient data and parameters required ...

  17. Scintigraphic evaluation of the esophageal-gastric function

    International Nuclear Information System (INIS)

    Taillefer, R.; Lefebvre, B.; Beauchamp, G.

    1986-01-01

    The authors present a brief review of the use of radionuclides in the pathophysiological evaluation of both esophageal and gastric function. Technical indications of these three following scintigraphic procedures are discussed: radionuclide esophagogram; gastro-esophogeal reflux study; and gastric emptying study

  18. Scintigraphic and clinical findings in the Standardbred metatarsophalangeal joint: 114 cases (1993-1995)

    International Nuclear Information System (INIS)

    Ross, M.W.

    1998-01-01

    To correlate scintigraphic and clinical findings of the metatarsophalangeal joint (MTPJ) in Standardbreds, radiographic findings in horses with confirmed MTPJ lameness, and determine if stress reaction and more advanced bone remodelling occurred in the MTPJ, medical records of 114 Standardbreds admitted between September 1993 and April 1995 in which bone scintigraphy included standing lateral and plantar views of the metatarsophalangeal joint (MTPJ) were reviewed. Images obtained using a large field of view gamma camera were evaluated visually for location, definition and intensity of increased radioisotope uptake (IRU), which was graded as mild, moderate, or intense. Clinical history and lameness examination findings were recorded and, in horses with documented MTPJ lameness, radiographic examination included the 30 degree (down-angled) dorsolateral 45 degree plantaromedial view thought to be useful in evaluation of the plantarolateral condyle of the third metatarsal bone (MtIII). The most common abnormality, IRU of the plantarolateral aspect of MtIII, was seen in 67 horses, and horses were further classified according to scintigraphic and clinical findings. In 43 horses in which lameness was not localised to the MTPJ, mild (32 horses), moderate (10 horses), and intense (one horse) IRU of MtHII was found. In 24 horses with lameness localised to the MTPJ, moderate (18 horses) and intense (6 horses) IRU was found. Of 18 horses with moderate IRU of MtIII, 9 had radiographic evidence of abnormal bony remodelling of MtIII, whereas 5 of 6 horses with intense IRU had radiographic changes. In 12 horses with MTPJ lameness and radiographic evidence of bony remodelling without fracture, radiographic changes consisted of plantarolateral subchondral radiolucency and sclerosis (7 horses), radiolucency and osteochondrosis (one horse), and plantar MtIII sclerosis without radiolucency (4 horses). In 2 horses with moderate IRU and MTPJ lameness, radiographic evidence of

  19. Novel CT and scintigraphic findings of bone metastasis from invasive lobular breast cancer.

    Science.gov (United States)

    Al-Ogaili, Zeyad; Troedson, Russell

    2016-02-01

    The aim of this study is to identify and describe the computed tomography and scintigraphic imaging patterns of osseous metastasis from invasive lobular breast cancer (ILC). CT and skeletal scintigraphy (SS) studies of 23 patients with diagnosis of ILC and osseous metastasis on their initial presentation were reviewed. Osseous metastases in 14 patients (60.8%) appear as uniform small sclerotic lesions (USSL) on CT scan. The SS in these patients were interpreted as negative for metastasis (either normal or with some equivocal findings not typical for metastasis). Osseous metastasis from ILC can have a characteristic imaging pattern on CT and SS. The pattern of USSL on CT scan with negative SS is highly suggestive of osseous metastasis from ILC. © 2015 The Royal Australian and New Zealand College of Radiologists.

  20. Novel CT and scintigraphic findings of bone metastasis from invasive lobular breast cancer

    International Nuclear Information System (INIS)

    Al-Ogaili, Zeyad; Troedson, Russell

    2016-01-01

    The aim of this study is to identify and describe the computed tomography and scintigraphic imaging patterns of osseous metastasis from invasive lobular breast cancer (ILC). CT and skeletal scintigraphy (SS) studies of 23 patients with diagnosis of ILC and osseous metastasis on their initial presentation were reviewed.Osseous metastases in 14 patients (60.8%) appear as uniform small sclerotic lesions (USSL) on CT scan. The SS in these patients were interpreted as negative for metastasis (either normal or with some equivocal findings not typical for metastasis). Osseous metastasis from ILC can have a characteristic imaging pattern on CT and SS. The pattern of USSL on CT scan with negative SS is highly suggestive of osseous metastasis from ILC.

  1. Scintigraphic follow-up of fracture healing in animals

    International Nuclear Information System (INIS)

    Klug, W.; Franke, W.G.; Schulze, M.

    1983-01-01

    Secondary bone fracture heating was analysed by scintigraphic follow-up studies in rabbits using sup(99m)Tc-HEDP. 24 hours after fracture the activity ratio between the fractured and the non-fractured lower limb was 2,2. The maximal count density in the fracture region is found during the 14th and 28th day after fracture. Concomitantly there is a significant increase of bone marrow vessels and content of copper, magnesium, sodium and water in the callus. Although roentgenographic controls and static investigations with respect to consolidation reveal a complete heating already 126 days after fracture, the complete scintigraphic normalisation of the lower limb fracture of the rabbit is found not earlier than at the 203rd day after fracture. (orig.) [de

  2. Scintigraphic follow-up of fracture healing in animals

    Energy Technology Data Exchange (ETDEWEB)

    Klug, W.; Franke, W.G.; Schulze, M.

    1983-08-01

    Secondary bone fracture healing was analysed by scintigraphic follow-up studies in rabbits using sup(99m)Tc-HEDP. 24 hours after fracture the activity ratio between the fractured and the non-fractured lower limb was 2,2. The maximal count density in the fracture region is found during the 14th and 28th day after fracture. Concomitantly there is a significant increase of bone marrow vessels and content of copper, magnesium, sodium and water in the callus. Although roentgenographic controls and static investigations with respect to consolidation reveal a complete healing already 126 days after fracture, the complete scintigraphic normalisation of the lower limb fracture of the rabbit is found not earlier than at the 203rd day after fracture.

  3. Radiographic and scintigraphic evaluation of total knee arthroplasty

    International Nuclear Information System (INIS)

    Schneider, R.; Soudry, M.

    1986-01-01

    Various radiographic and scintigraphic methods are used to supplement clinical findings in the evaluation of total knee arthroplasty and its complications. Serial roentgenograms offer reliable information for diagnosing mechanical loosening. Wide and extensive radiolucency at the cement-bone interface and shift in position and alignment of prosthetic components can be seen in almost all cases by the time revision is necessary. Radiographic abnormalities are usually not present in acute infection, but are often present in chronic infection. Bone scanning has a high sensitivity for diagnosis of infection or loosening, but is nonspecific because increased uptake is often present around asymptomatic total knee arthroplasties with normal radiographs. Differential bone and Gallium scanning and scanning with Indium 111-labeled leukocytes have a greater specificity for diagnosis of infection than does bone or Gallium scanning alone. Routine radiographic and scintigraphic studies have shown a high incidence of deep vein thrombosis in the calf after total knee arthroplasty. Clinically significant pulmonary embolization is infrequent

  4. The contribution of Spanish account planners to advertising effectiveness

    Directory of Open Access Journals (Sweden)

    Cristina Sánchez-Blanco, Ph.D.

    2010-01-01

    Full Text Available This paper aims to establish the account planner’s role and contribution in the creation of effective communication strategies for advertisers. Account Planning was born in 1968 in two advertising agencies in London, within the media and marketing context of that period. In the present circumstances, characterized by consumers’ protagonism and the need of an integrated communication, the account planner has acquired a more prominent role as the protector of the consumer. The account planner works to assure that commercial communication is based on in-depth research about the consumers and their characteristics. Thus, account planners add value to advertisers’ success because they are in charge of conducting correct brand positioning and effective communication strategies, focused on in-depth consumer knowledge.These theoretical reflections are more relevant when applied to the empirical study of the contemporary situation of account planners working in Spain, where Account Planning is a recent discipline. It was in the early 1990s when the first advertising agencies adopted this function for the first time, however, in less than 20 years account planning has become a key department in commercial communication. The empirical study is based on a survey applied to professional of account planning working Spain.

  5. Survey of 26 suprarenal scintigraphs on Cushing's syndrome patients

    International Nuclear Information System (INIS)

    Venot, A.; Luton, J.P.; Roucayrol, J.C.; Bricaire, H.

    On the basis of the results of 26 Cushing's syndrome examinations some new scintigraphic aspects are described, suprarenal scintigraphy is compared with retroperitoneal insufflation, its value in the observation of a medical treatment of Cushing's disease is demonstrated and finally some preliminary results are given on the application in the same pathological context, of 75 Se-6-selenocholesterol which was compared with 131 I-19-iodocholesterol [fr

  6. Acetabular stress fractures in military endurance athletes and recruits: incidence and MRI and scintigraphic findings

    International Nuclear Information System (INIS)

    Williams, T.R.; Puckett, M.L.; Shin, A.Y.; Gorman, J.D.; Denison, G.

    2002-01-01

    Objective: To evaluate the incidence and the MRI and scintigraphic appearance of acetabular stress (fatigue) fractures in military endurance athletes and recruits. Design and patients: One hundred and seventy-eight active duty military endurance trainees with a history of activity-related hip pain were evaluated by both MRI and bone scan over a 2-year period. Patients in the study ranged in age from 17 to 45 years. They had hip pain related to activity and had plain radiographs of the hip and pelvis that were interpreted as normal or equivocal. The study was originally designed to evaluate the MRI and scintigraphic appearance of femoral neck stress fractures. Patients had scintigraphy and a limited MRI examination (coronal imaging only) within 48 h of the bone scan. Twelve patients demonstrated imaging findings compatible with acetabular stress fractures. Results: Stress fractures are common in endurance athletes and in military populations; however, stress fracture of the acetabulum is uncommon. Twelve of 178 patients (6.7%) in our study had imaging findings consistent with acetabular stress fractures. Two patterns were identified. Seven of the 12 (58%) patients had acetabular roof stress fractures. In this group, two cases of bilateral acetabular roof stress fractures were identified, one with a synchronous tensile sided femoral neck stress fracture. The remaining five of 12 (42%) patients had anterior column stress fractures, rarely occurring in isolation, and almost always occurring with inferior pubic ramus stress fracture (4 of 5, or 80%). One case of bilateral anterior column stress fractures was identified without additional sites of injury. Conclusions: Stress fractures are commonplace in military populations, especially endurance trainees. Acetabular stress fractures are rare and therefore unrecognized, but do occur and may be a cause for activity-related hip pain in a small percentage of military endurance athletes and recruits. (orig.)

  7. Gastroesophageal reflux disease. Scintigraphic, endoscopic and histologic considerations

    Energy Technology Data Exchange (ETDEWEB)

    Kault, B.; Halvorsen, T.; Petersen, H.; Grette, K.; Myrvold, H.E.

    1986-01-01

    Radionucleotide scintigraphy and esophagoscopy with biopsy were carried out in 101 patients with symptoms strongly suggestive of gastroesophageal reflux (GER) disease. GER was visualized by scintigraphy in 86.1% of the patients. Endoscopic and histologic esophagitis were found in 68.1% and 58.4% of the patients, respectively, whereas both examinations taken together showed evidence of esophagitis in 82%. Histologic evidence of esophagitis was found in nearly all patients with severe endoscopic changes, and in 43.7% of the patients with no endoscopic abnormality. Scintigraphic reflux was demonstrated more frequently in the patients with severe endoscopic esophagitis (97.5%) than in those with no or only mild endoscopic changes (78.6%). Scintigraphic reflux was found in 91.5% and 78.5% of the patients with and without histologic evidence of esophagitis. 15 of the 18 patients (83.3%) without endoscopic and histologic abnormalities in the esophagus had scintigraphic evidence of reflux. The present study strongly supports the clinical significance of scintigraphy in GER disease and confirms that esophageal biopsy specimens increase the sensitivity of endoscopic evaluation. 31 refs.

  8. Acute rhabdomyolysis of the soleus muscle induced by a lightning strike: magnetic resonance and scintigraphic findings

    International Nuclear Information System (INIS)

    Watanabe, Naofumi; Inaoka, Tsutomu; Shuke, Noriyuki; Takahashi, Koji; Aburano, Tamio; Chisato, Naoyuki; Go, Kazutomo; Nochi, Hitoshi

    2007-01-01

    Among natural disasters, a lightning strike is a rare but potentially life-threatening phenomenon. If victims survive a cardiac arrest due to instantaneous passage of an exceptionally high voltage electric charge through the whole body, they may be afflicted with various complications such as muscle necrosis resulting in acute renal failure. In this article, we report a case of a 54-year-old man with acute rhabdomyolysis of the left soleus muscle associated with a lightning strike. T2-weighted and short-tau inversion recovery MR images showed a high signal intensity in the left soleus muscle. A whole-body bone scintigram showed abnormal uptakes in the left soleus muscle and the dorsal aspect of the left foot. MR and scintigraphic evaluations were very useful in depicting the site and extent of muscle damage. Since the patient showed a surprisingly high level of serum creatine kinase, the added information was very valuable for determining the patient's management. (orig.)

  9. Right ventricular function: methodologic and clinical considerations in noninvasive scintigraphic assessment

    International Nuclear Information System (INIS)

    Manno, B.V.; Iskandrian, A.S.; Hakki, A.H.

    1984-01-01

    Right ventricular function plays an important role in many cardiac disorders. Changes in left ventricular function, right ventricular afterload and preload, cardiac medications and ischemia may affect right ventricular function. Radionuclide ventriculography permits quantitative assessment of regional and global function of the right ventricle. This assessment can be made at rest, during exercise or after pharmacologic interventions. The overlap between right ventricle and right atrium is a major limitation for gated scintigraphic techniques. The use of imaging with newer short-lived radionuclides may permit more accurate and reproducible assessment of right ventricular function by means of the first pass method. Further work in areas related to improvement of techniques and the impact of right ventricular function on prognosis is needed

  10. Scintigraphic test of gastric emptying and motility: preliminary results in patients with chronic gastritis

    Energy Technology Data Exchange (ETDEWEB)

    Hausmann, T. [Abt. Nuklearmedizin und Spezielle Biophysik, Medizinische Hochschule Hannover (Germany); Mueller-Schauenburg, W. [Abt. Nuklearmedizin, Univ. Tuebingen (Germany); Goeke, M. [Abt. Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover (Germany); Luebeck, M. [Abt. Nuklearmedizin, Univ.-Krankenhaus Eppendorf, Hamburg (Germany); Gratz, K.F. [Abt. Nuklearmedizin und Spezielle Biophysik, Medizinische Hochschule Hannover (Germany); Meier, P. [Abt. Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover (Germany); Manns, M. [Abt. Gastroenterologie und Hepatologie, Medizinische Hochschule Hannover (Germany); Hundeshagen, H. [Abt. Nuklearmedizin und Spezielle Biophysik, Medizinische Hochschule Hannover (Germany)

    1995-11-01

    To record gastric peristalsis using a conventional scintigraphic gastric emptying test the frame rate was increased to 1 frame per 3 s at 10, 30, and 50 min postprandially. The gastric contraction frequency was obtained from the first harmonic of a Fourier transform of a gastric region of interest (ROI) curve. The propagation of gastric contractions was better revealed from computed functional images of the phase and amplitude distribution as compared with the multiple scintigraphic images. The maximal count-rate changes per pixel were calculated as an estimate of the most prominent regional contractile activity of the gastric wall. Among 12 patients with chronic gastritis the group with more severe dyspeptic complaints (n = 6) had significantly higher count-rate changes per pixel when compared with the group with minor complaints (20.0, 21.1 and 14.2 vs 12.9, 12.0, and 10.4 counts/pixel X s at 10, 30, and 50 min. respectively; p < 0.05). The mean half-times of gastric emptying (61, SD 11 vs 54, SD 13 min) and the mean gastric contraction frequencies (2.99, SD 0.19; 3.09, SD 0.33; 3.07, SD 0.10 vs 3.15, SD 0.15; 3.17, SD 0.13; 3.23, SD 0.20 cycles/min at 10, 30, and 50 min, respectively) did not show significant differences between both groups. Our preliminary results agree with the hypothesis of the occurrence of more powerful, nonexpulsive gastric-wall contractions in patients with more severe dyspeptic complaints. Hence, additional quantification of gastric motility allowed a more detailed evaluation of gastric-motor-activity disorders that were for so long not accessible to conventional gastric-emptying tests. (orig.)

  11. Scintigraphic test of gastric emptying and motility: preliminary results in patients with chronic gastritis

    International Nuclear Information System (INIS)

    Hausmann, T.; Mueller-Schauenburg, W.; Goeke, M.; Luebeck, M.; Gratz, K.F.; Meier, P.; Manns, M.; Hundeshagen, H.

    1995-01-01

    To record gastric peristalsis using a conventional scintigraphic gastric emptying test the frame rate was increased to 1 frame per 3 s at 10, 30, and 50 min postprandially. The gastric contraction frequency was obtained from the first harmonic of a Fourier transform of a gastric region of interest (ROI) curve. The propagation of gastric contractions was better revealed from computed functional images of the phase and amplitude distribution as compared with the multiple scintigraphic images. The maximal count-rate changes per pixel were calculated as an estimate of the most prominent regional contractile activity of the gastric wall. Among 12 patients with chronic gastritis the group with more severe dyspeptic complaints (n = 6) had significantly higher count-rate changes per pixel when compared with the group with minor complaints (20.0, 21.1 and 14.2 vs 12.9, 12.0, and 10.4 counts/pixel X s at 10, 30, and 50 min. respectively; p < 0.05). The mean half-times of gastric emptying (61, SD 11 vs 54, SD 13 min) and the mean gastric contraction frequencies (2.99, SD 0.19; 3.09, SD 0.33; 3.07, SD 0.10 vs 3.15, SD 0.15; 3.17, SD 0.13; 3.23, SD 0.20 cycles/min at 10, 30, and 50 min, respectively) did not show significant differences between both groups. Our preliminary results agree with the hypothesis of the occurrence of more powerful, nonexpulsive gastric-wall contractions in patients with more severe dyspeptic complaints. Hence, additional quantification of gastric motility allowed a more detailed evaluation of gastric-motor-activity disorders that were for so long not accessible to conventional gastric-emptying tests. (orig.)

  12. 201Tl scintigraphic evaluation of tumor mass and viability of bone and soft-tissue tumors

    International Nuclear Information System (INIS)

    Tsuda, Takatoshi; Kubota, Masahiro; Yoshida, Satoru; Shibata, Masahito; Wakabayashi, Jun-ichi; Obata, Hiroyuki; Matsuyama, Toshikatsu; Usui, Masamichi; Ishii, Sei-ichi.

    1994-01-01

    To characterize 201 Tl uptake in patients with bone and soft-tissue tumor, we studied 49 patients with surgically proven tumors and one patient with a tumor diagnosed arteriographically. In 37 of our 50 patients, the tumor was evaluated with 201 Tl and arteriography. Moreover, in 14 of patients with pre-operative chemotherapy, pathologic changes were graded on the basis of percent tumor necrosis as defined histologically. The percent tumor necrosis histologically was compared with changes in the scintigraphic and conventional angiographic studies. Radiologic comparisons demonstrated a high degree of correlation with images of 201 Tl and both arterial and blood pool phase of 99m Tc-HMDP. Ninety-six percent of 28 malignant tumors had positive 201 Tl uptake. None of the patients showed any thallium accumulation in the soft tissues or skeleton adjacent to the lesion. Activity of 201 Tl was mainly dependent upon a tumor blood flow and a vascular density. In of 14 cases with the preoperative chemotherapeutic treatment, 201 Tl scintigraphic changes showed concordance with % tumor necrosis. Thallium-201 was superior to 99m Tc-HMDP in predicting tumor response to chemotherapy. Interestingly, delayed images of 99m Tc-HMDP of 5 responders with >90% tumor necrosis showed decreased uptake in the adjacent bone to the tumor mass lesions. It seems to be quite all right to consider that a major determinant of 201 Tl uptake is intratumoral angiogenecity, which is closely connected with tumor viability. Therefore, 201 Tl is a sensitive radiopharmaceutical for detection of vascular rich bone and soft-tissue tumors, and appears to be a simple and an accurate test for evaluating the response to specific therapeutic regimens of malignant bone and soft-tissue tumors. (author)

  13. Scintigraphic and echographic thyroid image matching by a stereoscopic method

    International Nuclear Information System (INIS)

    Ballet, E.; Rousseau, J.; Marchandise, X.; Cussac, J.F.; Ballet, E.; Vasseur, C.; Gibon, D.

    1997-01-01

    We developed a device which allows us to match echographic data and scintiscanning data in a common 3D reference system. In thyroid exploration, this device completes the nuclear medicine examination by specifying simultaneously volume and echo-structure of the gland. Positions of γ-camera and echograph are determined in a 3D reference system using the stereo-vision principle: two CCD cameras allow locating of both sensors within 1.6 m, and sensors may be moved in a 0.4 m x 0.4 m FOV. Real time computation is reduced by limiting data to be treated to light emitters landmarks mounted on the sensor and used to calculate its position and its orientation. Matching accuracy is better than 0.5 mm for position, and better than 0.35 deg for orientation. Sensor marking average time is lesser than 0.5 s. (authors)

  14. Collaboration between physical activity researchers and transport planners

    DEFF Research Database (Denmark)

    Crist, Katie; Bolling, Khalisa; Schipperijn, Jasper

    2018-01-01

    Collaboration between physical activity (PA) researchers and transport planners is a recommended strategy to combat the physical inactivity epidemic. Data collected by PA researchers could be used to identify, implement and evaluate active transport (AT) projects. However, despite aligned interests......, researchers and transport planners rarely collaborate. This study utilized qualitative methods to 1) gain an in-depth understanding of the data utilized in AT planning, 2) explore the utility of Global Positioning Systems (GPS) and accelerometer data in supporting the planning process, 3) identify...... expertise in health or transport planning. A thematic analysis was conducted following structural coding by two researchers. The analysis revealed that geographic and physical activity data that are current, local, objective and specific to individual AT trips would improve upon currently available data...

  15. Teaching planning theory as planner roles in urban planning education

    DEFF Research Database (Denmark)

    Olesen, Kristian

    2018-01-01

    Planning theory is often portrayed as a subject that urban planning students find too abstract and fail to see the relevance of. This paper advocates the perspective that planning theory can be made more student-friendly. This requires, firstly, that academic discussions about the relevance...... of planning theory for urban planning practice are integrated into the course module. If students are to appreciate planning theory, it requires that they understand how planning theory can inspire planning practice. Secondly, it requires careful considerations to the pedagogy of planning theory. The paper...... suggests that teaching planning theory as a variety of planner roles offers a helpful pedagogical approach for helping students construct their identities as urban planners. The paper builds on the author’s own experiences of teaching planning theory in a master’s urban planning programme, and has been...

  16. Scintigraphic examination of the sympathicoadrenal system

    International Nuclear Information System (INIS)

    Dabasi, Gabriella; Duffek, Laszlo

    1989-01-01

    Experiences with 100 131 I-metaiodo-benzylguanidine (MIGB) scintigraphy are described. The importance of the examination is stressed in the diagnostics of neuroblastoma in childhood and in the determination of the clinical stage and follow-up of the disease. MIGB scintigraphy plays a primary role in the imaging examination procedures aimed at the localization of pheochromocytoma, especially in the extraadrenal, multiplex and malignant diseases. The disturbance of adrenergic innervation in Shy-Drager syndrome can be demonstrated with radiopharmacon. (author) 19 refs.; 5 figs

  17. Scintigraphic demonstration of acute myocardial infarcts

    International Nuclear Information System (INIS)

    Holman, B.L.; Lesch, M.

    1976-01-01

    The feasibility of acute infarct scintigraphy for the clinical evaluation of patients with known or suspected acute myocardial infarction is established. Further development of this methodologic approach may result in even better agents for the visualization of infarcts. Radiotracers with high affinity for the infarct, rapid blood clearance, and low concentrations in surrounding organs, such as liver and bone, would be more suitable than available radiopharmaceuticals for acute myocardial infarct scintigraphy. Ultimately, labeling these tracers and ultra-short-lived radionuclides will enable rapid sequential imaging to assess changes in the extent of infarction and to determine the efficacy of therapies aimed at limiting infarct size

  18. Scintigraphic demonstration of acute gastrointestinal bleeding

    Energy Technology Data Exchange (ETDEWEB)

    Alavi, A.

    1980-01-01

    Acute gastrointestinal bleeding may be localized using noninvasive radionuclide methods. We have favored the use of technetium-99m sulfur colloid with sequential imaging because of the rapid clearance of background activity. Definition of the site of upper gastrointestinal bleeding, however, may be obscured by intense uptake of radioactivity by liver and spleen. The sensitivity of the method is such that the bleeding rates of 0.05-0.1 ml/min can be detected compared to a sensitivity of 0.5 ml/min for angiography.

  19. Development of superior bone scintigraphic agent from a series of {sup 99m}Tc-labeled zoledronic acid derivatives

    Energy Technology Data Exchange (ETDEWEB)

    Lin Jianguo [Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063 (China); Qiu Ling, E-mail: qiulingwx@gmail.com [Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063 (China); Cheng Wen [Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063 (China); Luo Shineng, E-mail: shineng914@yahoo.com.cn [Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063 (China); Xue Li; Zhang Shu [Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063 (China)

    2012-05-15

    Two novel zoledronic acid (ZL) derivatives, 1-hydroxy-4-(1H-imidazol-1-yl)butane-1,1-diyldiphosphonic acid (IBDP) and 1-hydroxy-5-(1H-imidazol-1-yl)pentane-1,1-diyldiphosphonic acid (IPeDP), were prepared and labeled with the radionuclide technetium-99m in a high labeling yield. In vitro stabilities of these radiolabeled complexes were measured by the radio-HPLC analysis as a function of time, which showed excellent stability with the radiochemical purity of over 95% at 6 h post preparation. Their in vivo biological performances were evaluated and compared with those of {sup 99m}Tc-ZL and {sup 99m}Tc-MDP (methylenediphosphonic acid). The biodistribution in mice and scintigraphic images of the rabbit showed that the tracer agent {sup 99m}Tc-IPeDP had highly selective uptake in the skeletal system and rapid clearance from the blood and soft tissues and an excellent scintigraphic image can be obtained in a shorter time post injection with clear visualization of the skeleton and low soft tissue activity. These preclinical studies suggest that {sup 99m}Tc-IPeDP would be a novel superior bone scintigraphic agent. - Highlights: Black-Right-Pointing-Pointer Two novel diphosphonic acids were labeled with the {sup 99m}Tc in high labeling yield. Black-Right-Pointing-Pointer {sup 99m}Tc-IPeDP had high uptake in skeletal system and rapid clearance from blood. Black-Right-Pointing-Pointer {sup 99m}Tc-IPeDP reveals attractive biological features as superior bone scanning agent.

  20. Scintigraphic appearance of focal fatty infiltration of the liver using single-photon emission computed tomography

    International Nuclear Information System (INIS)

    Kudo, M.; Hirasa, M.; Ibuki, Y.

    1984-01-01

    Fatty infiltration of the liver had been considered to assume a uniform distribution until quite recently. However, the development of X-ray computed tomography (XCT) and the ultrasound (US) has proven that fatty infiltration of the liver may sometimes assume a nonuniform distribution (focal fatty infiltration (FFI)). This investigation was undertaken to evaluate the scintigraphic appearance of FFI using single-photon emission computed tomography (SPECT) with a GE Maxicamera 400T. Radionuclide images including SPECT were evaluated in 12 cases with FFI which were diagnosed by XCT and US. Most of them were histrogically confirmed to be positive fatty infiltration in the liver. The results were as follows. The fatty infiltrated area was visualized as a hot spot in one case, a defect in 2 cases, a low uptake in one case and a normal uptake in 8 cases. Radionuclide imaging of FFI shows a large variety of findings and it suggests that Kupffer cell function varies with the causes or stage of fatty infiltration. And one can understand the pathological state of FFI from a viewpoint of Kupffer cell function only by radionuclide imaging including SPECT, which is very useful to compare the images with XCT images

  1. Scintigraphic instruments and techniques in nuclear medicine

    International Nuclear Information System (INIS)

    Bornand, Bernard; Soussaline Francoise

    1979-11-01

    This bibliographical supplement brings out the importance assumed from now on by comparative studies on various imagery systems: radioisotopic scintigraphy, computerized tomography and ultra sonography. Another aspect to emerge is the anxiety of the medical world faced with ethical and economic problems in weighing up as accurately as possible the justifiability and consequences of clinical decisions, hence the value of visual observations and interpretations of images, as well as the quality of the instruments used. Four lists of bibliographical notices with abstracts covering the period late 1976-early 1979 mention 258 articles from journals, 67 conference lectures, 13 reports, 3 theses and 44 invention patents respectively. To these lists are attached the author, inventor and subject indices [fr

  2. Scintigraphic detection of inflammatory heart disease

    International Nuclear Information System (INIS)

    Morguet, A.J.; Munz, D.L.; Kreuzer, H.; Emrich, D.

    1994-01-01

    Inflammatory diseases of the heart encompass myocarditis, endocarditis and pericarditis. This paper discusses the diagnostic potential of scintigraphy in these entities. In myocarditis, indium-111 antimyosin Fab imaging can visualize active myocyte damage and thus contribute substantially to the diagnosis. Antimyosin uptake is also seen in a large subset of patients with dilated cardiomyopathy, indicating ongoing myocyte injury in these cases. In endocarditis, immunoscintigraphy using monoclonal technetium-99m-labelled antigranulocyte antibodies provides useful diagnostic information in patients with equivocal echocardiographic findings. Immunoscintigraphy seems to indicate the floridity of the inflammatory process in endocarditis and may be used to monitor antibiotic therapy. In pericarditis, the clinical value of scintigraphy has not been convincingly demonstrated. (orig.)

  3. Scintigraphic detection of inflammatory heart disease

    Energy Technology Data Exchange (ETDEWEB)

    Morguet, A J [Dept. of Cardiology and Pulmonology, Centre of Internal Medicine, Georg August Univ., Goettingen (Germany); Munz, D L [Dept. of Nuclear Medicine, Centre of Radiology, Georg August Univ., Goettingen (Germany); Kreuzer, H [Dept. of Cardiology and Pulmonology, Centre of Internal Medicine, Georg August Univ., Goettingen (Germany); Emrich, D [Dept. of Nuclear Medicine, Centre of Radiology, Georg August Univ., Goettingen (Germany)

    1994-07-01

    Inflammatory diseases of the heart encompass myocarditis, endocarditis and pericarditis. This paper discusses the diagnostic potential of scintigraphy in these entities. In myocarditis, indium-111 antimyosin Fab imaging can visualize active myocyte damage and thus contribute substantially to the diagnosis. Antimyosin uptake is also seen in a large subset of patients with dilated cardiomyopathy, indicating ongoing myocyte injury in these cases. In endocarditis, immunoscintigraphy using monoclonal technetium-99m-labelled antigranulocyte antibodies provides useful diagnostic information in patients with equivocal echocardiographic findings. Immunoscintigraphy seems to indicate the floridity of the inflammatory process in endocarditis and may be used to monitor antibiotic therapy. In pericarditis, the clinical value of scintigraphy has not been convincingly demonstrated. (orig.)

  4. Scintigraphic evaluation of floating, gastroretentive formulation of clarithramycin in healthy human volunteers

    International Nuclear Information System (INIS)

    Ali, Raisuddin; Aji Alex, M.R.; Dutta, M.; Singh, Thakuri; Bhatnagar, A.; Bajaj, M.; Singla, Y.P.; Ahmad, F.J.; Khar, R.K.

    2010-01-01

    Full text: Objective of the present study concerns formulation and evaluation of oral buoyant effervescent tablets of clarithromycin for prolongation of gastric residence time (GRT) and to enhance eradication of Helicobacter pylori (H. pylori) for longer period of time. Materials and Methods: Clarithromycin (CLA) a macrolide antibiotic was chosen as the candidate drug for its immense potential as an Anti H. pylori agent. HPMC and/or xanthan gum were used as release-retarding polymer(s) whereas sodium bicarbonate (NaHCO 3 ) was utilized as a gas former. The tablets were prepared by wet granulation method. Formulations were evaluated for physicochemical properties, in vitro drug release as well as drug release kinetics and stability studies. In vivo gamma scintigraphic studies were assessed for the optimized buoyant gastroretentive tablets in six healthy human volunteers to study influence of nature of the dosage form i.e. conventional or sustained release gastroretentive tablets and the presence of food in the stomach on intragastric performance of gastroretentive tablets. Result: The fabricated tablets showed acceptable physiochemical properties. Non-fickian release transport was confirmed as the drug release mechanism from the prepared tablets. Optimized tablets composed of HPMC K15M, xanthan gum, and NaHCO 3 were promising systems exhibiting excellent floating properties. The overall performance was found to be highly sustained. Scintigraphic imaging revealed GRT of 320 min or more in fed state on the other hand GRT of 180 min or less in case of unfed state. Conclusion: The developed gastroretentive system has potential to increase efficacy of the therapy and improve patient

  5. Scintigraphic examinations after stent implantation in central airways

    International Nuclear Information System (INIS)

    Richter, W.S.; Kettner, B.I.; Munz, D.L.

    1998-01-01

    Endotracheal and endobronchial stent implantation has been developed as an effective treatment of benign and malignant airway stenosis and of tracheo- or bronchoesophageal fistulas. The selection of the stent type depends on the kind and site of disease. Chest X-ray and bronchoscopy are the procedures of choice for monitoring of stent position, structure, and function. However, with scintigraphic methods the effects of stent implantation on pulmonary ventilation and perfusion can be assessed non-invasively. The validation of the effect of a stent implantation on mucociliary and tussive clearance remains to be elucidated. (orig.) [de

  6. Hyper-functioning Thyroid Nodule with Scintigraphic Owl's Eye Appearance

    International Nuclear Information System (INIS)

    Al-Kordi, R.S.; Elgazzar, A.H.

    2006-01-01

    Hyper-functioning thyroid nodules may produce various scintigraphic appearances on thyroid scans. Autonomously hyper functioning thyroid nodules invariably demonstrate degenerative changes. These changes may give rise to central or less commonly peripheral photopenic areas on a thyroid scan within otherwise a hot nodule. In this report we present a case of hyper functioning autonomous nodule with peripheral degeneration and residual central functioning tissue giving the appearance of an owl's eye. Although rare, this pattern can be seen in a variety of benign and malignant thyroid conditions. (author)

  7. Differential diagnosis of scintigraphic brain centres by 75Se selenite

    International Nuclear Information System (INIS)

    Bestagno, M.; Garraffa, V.; Rembado, R.; Guerra, U.

    1975-01-01

    Since standard brain scintigraphy with sup(99m)Tc is not always adequate for a satisfactory differential diagnosis of the radioactive foci detected, the possibilities of 75 Se sodium selenite were investigated. It was observed that in centres due to a vascular lesion the selenite concentration is always low, rising steeply in neoplasmic foci. The 75 Se-selenite scintigraphic method is considered highly valid, complementing that of sup(99m)Tc when this latter is unsuitable for diagnosis of the nature of cerebral foci [fr

  8. Scintigraphic colonic transit study in children with chronic constipation

    International Nuclear Information System (INIS)

    Yano, Tsunehiro; Uemura, Sadashige; Nakaoka, Tatsuo; Nakagawa, Yoshikiyo; Tanimoto, Terutaka; Sone, Teruki

    2008-01-01

    Chronic constipation can be caused either by slow colonic transit or by functional fecal retention. The treatment strategy for chronic constipation should be based on its etiology. Scintigraphic colonic transit study (SCTS) is useful for dividing the cause of the constipation into slow colonic transit and functional fecal retention. SCTS is also useful for judging the therapeutic effect and postoperative intestinal motility of Hirschsprung's disease, anorectal molformation, and others. As SCTS is a safe, simple, and painless examination, it is one of the most important examinations in evaluating chronic constipation. (author)

  9. Liquid scintigraphic gastric emptying - is it reproducible?

    International Nuclear Information System (INIS)

    Cooper, R.G.; Shuter, B.; Leach, M.; Roach, P.J.

    1999-01-01

    Full text: Radioisotope gastric emptying (GE) studies have been used as a non-invasive technique for motility assessment for many years. In a recent study investigating the correlation of mesenteric vascular changes with GE, six subjects had a repeat study 2-4 months later. Repeat studies were required due to minor technical problems (5 subjects) and a very slow GE (I subject) on the original study. Subjects drank 275 ml of 'Ensure Plus' mixed with 8 MBq 67 Ga-DTPA and were imaged for 2 h while lying supine. GE time-activity curves for each subject were generated and time to half emptying (T l/2 ) calculated. Five of the six subjects had more rapid GE on the second study. Three of the subjects had T l/2 values on their second study which were within ± 15 min of their original T l/2 . The other three subjects had T l/2 values on their second study which were 36 min, 55 min and 280 min (subject K.H.) less than their original T l/2 . Statistical analysis (t-test) was performed on paired T l/2 values. The average T l/2 value was greater in the first study than in the second (149 ± 121 and 86 ± 18 min respectively), although the difference was not statistically significant (P ∼ 0.1). Subjects' anxiety levels were not quantitated during the GE study; however, several major equipment faults occurred during the original study of subject K.H., who became visibly stressed. These results suggest that the reproducibility of GE studies may be influenced by psychological factors

  10. Scintigraphic study of gastric emptying with colloidal tin

    International Nuclear Information System (INIS)

    Rodríguez Paleo, Lester; Nuez Vilar, Maricela; Machado Lois, Marisel; López González, María Karla; Torres Leyva, Oscar; Izquierdo Izquierdo, Yimel; García González, Idelsy; Conesa Gonzalez, Ana Ibis

    2016-01-01

    Gastroparesis is defined as a delay in gastric emptying in the absence of mechanical obstruction, associated with symptoms such as nausea and / or vomiting, feeling of postprandial gastric fullness, early satiety or epigastric pain for more than 3 months. The gold standard in the diagnosis of delayed gastric emptying scintigraphy is gastric emptying and radiopharmaceutical has been used more 99m Tc-sulfur colloid not available in the country. In order to evaluate the usefulness of colloidal tin in the scintigraphic gastric emptying study, a descriptive study was conducted in 64 patients over 18 years using as radiopharmaceutical 99m Tc-Sn colloid. 31% of patients had symptoms. The emptying time was normal in 50 cases and the association of gastroparesis symptoms was observed in 20 (15 diabetic and 5 non-diabetic), 9 patients had a delayed emptying, but reported no symptoms. Gastroparesis was more frequent in women than in men (35% versus 21%). 21% of patients had a moderate delayed gastric emptying. Conclusions: The results obtained with 99m Tc-Sn colloid are comparable to those reported by other authors using 99m Tc-SC in the scintigraphic assessment of gastric emptying. (author)

  11. Scintigraphic portrayal of β receptors in the heart

    International Nuclear Information System (INIS)

    Sisson, J.C.; Wieland, D.M.; Koeppe, R.A.; Normolle, D.; Frey, K.A.; Bolgos, G.; Johnson, J.; Van Dort, M.E.; Gildersleeve, D.L.

    1991-01-01

    Myocardial β adrenergic receptors play important roles in physiology and disease, but the receptors have not before been portrayed. The β antagonist, iodocyanopindolol (ICYP), was used to develop a scintigraphic method for depicting the receptors in the living heart. Labeled with 125I, ICYP bound firmly to β receptors in the rat heart; the data conformed to a mathematical model. In vivo saturation kinetics indicated binding sites with two affinities. Inhibition of ICYP binding by beta antagonists of different potency and different selectivity for β-1 and β-2 receptors produced the expected pharmacologic effects. Inhibition by lipophilic and hydrophilic antagonists gave no evidence that ICYP was appreciably bound to internalized receptors. Fractional binding by tracer quantities of (-) ICYP and ± ICYP demonstrated stereospecificity. Labeled with 123I, ICYP bound to the hearts of intact dogs so that scintigraphic tomographs depicted ventricular myocardium. Small doses of beta antagonists selectively reduced the binding of ICYP to lung enabling better visualization of the heart. Thus, 123I-ICYP appears to portray the beta receptors in the living heart, and the characteristics of binding permit the development of mathematical models and lay the basis for quantifying this receptor binding

  12. /sup 99m/Tc-aminohexylidendiphosphonate and /sup 99/mTc-Pyrophosphate in the scintigraphic diagnosis of experimental cardiomyopathy in dogs

    Energy Technology Data Exchange (ETDEWEB)

    Duska, F; Kafka, P; Mazurova, Y; Hadas, L; Vizda, J; Palicka, V; Grossman, V

    1987-10-01

    Experimental cardiomyopathy was provoked in 24 dogs with high intravenous doses of adrenaline and theophylline. These lesions were studied by means of the new agent /sup 99m/Tc-AHDP and /sup 99m/Tc-PYP in comparison. Cardiomyopathy could be imaged as early as 4 h after the onset of involvement but not later than 7 days. A maximum accumulation occurred in lesions 24 h old, /sup 99m/Tc uptake in the myocardium was graded scintigraphically, /sup 99m/Tc-AHDP was accumulated in the altered myocardium to a greater extent than /sup 99m/Tc-PYP. Scintigraphic findings were in good agreement with plasma levels of creatine-kinase. A comparison with histology demonstrated that the maximum accumulation of radiopharmaceuticals occurred at the time when the development of myocardium involvement reached the stage of myocytolysis.

  13. Gallium-68 DOTA-TATE Positron Emission Tomography/Computed Tomography: Scintigraphic Changes of Adrenal Glands Following Management of Ectopic Cushing's Syndrome by Steroidogenesis Inhibitors

    International Nuclear Information System (INIS)

    Huang, Yu-Ting; Aziz, Shaikh Irfan; Kumar, Aravind S. Ravi

    2014-01-01

    In the era of emerging functional imaging techniques, an understanding of the effects of hormonal therapies on the scintigraphic appearance of endocrine organs is desirable to minimize the erroneous scan interpretation. The mechanisms by which changes in the scintigraphic appearance of endocrine organs occur however sometimes remain ambiguous. This case demonstrates the gallium-68 (Ga-68) DOTA-TATE positron emission tomography/computed tomography (CT) appearance of adrenal glands following management with steroidogenesis inhibitors. The potential mechanisms underlying this change are discussed. A 17-year-old boy with adrenocorticotropic hormone (ACTH) dependent Cushing's syndrome secondary to ectopic ACTH secretion underwent pre- and post-metyrapone and dexamethasone treatment Ga-68 DOTA-TATE scans 4 months apart. Pretreatment, both adrenals demonstrated normal symmetrical prominent Ga-68 DOTA-TATE uptake and normal CT appearance. The posttherapy scan revealed marked symmetrical suppression of Ga-68 DOTA-TATE uptake, but with bilateral adrenal hypertrophy on CT

  14. A Door-to-Door Combined Transport Planner

    DEFF Research Database (Denmark)

    Aastrup, Jesper; Jespersen, Per Homann; Pedersen, Michael B.

    2004-01-01

    Establishing a web-based portal functioning as a one-stop-shop for transport buyers is a radical idea of a consumer oriented intermodal freight system. This utopian vision will be materialized in a system description and a prototype of a Door-to-Door Combined Trans-port Planner (COTRAP), developed......- and inter-organizational barriers to the establishment of a competitive and effective combined transport system with rail freight operators as the intermodal integrator. In this paper we describes the ideas and methodology behind the project, as well as some preliminary results....

  15. Doubling time of liver metastase images

    International Nuclear Information System (INIS)

    Bittighoffer, Bernard.

    1975-01-01

    For our study, where clinical and scintigraphic observation seldom lasts more than two years and where measurable metastases always exceed 1 cm 3 , the exponential model was adopted and our results were all calculated with GERSTENBERG's formula which gives an apparent doubling time. The liver metastases were measured on the scintigraphic image obtained, a more or less sharply limited blank which makes for a first difficulty of judgement. Two magnascanner V type PICKER 5-inch crystal scintigraphs were used, giving three images simultaneously by a transcriber made up of a stylus and a light spot built into the detection system. The isotope used is colloidal gold ( 198 Au) phagocytized by the Kuepfferian reticulo-endothelial system. The doubling time for liver metastase scintigraphic images calculated for fifteen patients having undergone one or more isotopic checks after a first metastase image was discovered range from 10 to 103 days [fr

  16. Compiling quantum circuits to realistic hardware architectures using temporal planners

    Science.gov (United States)

    Venturelli, Davide; Do, Minh; Rieffel, Eleanor; Frank, Jeremy

    2018-04-01

    To run quantum algorithms on emerging gate-model quantum hardware, quantum circuits must be compiled to take into account constraints on the hardware. For near-term hardware, with only limited means to mitigate decoherence, it is critical to minimize the duration of the circuit. We investigate the application of temporal planners to the problem of compiling quantum circuits to newly emerging quantum hardware. While our approach is general, we focus on compiling to superconducting hardware architectures with nearest neighbor constraints. Our initial experiments focus on compiling Quantum Alternating Operator Ansatz (QAOA) circuits whose high number of commuting gates allow great flexibility in the order in which the gates can be applied. That freedom makes it more challenging to find optimal compilations but also means there is a greater potential win from more optimized compilation than for less flexible circuits. We map this quantum circuit compilation problem to a temporal planning problem, and generated a test suite of compilation problems for QAOA circuits of various sizes to a realistic hardware architecture. We report compilation results from several state-of-the-art temporal planners on this test set. This early empirical evaluation demonstrates that temporal planning is a viable approach to quantum circuit compilation.

  17. Color planner for designers based on color emotions

    Science.gov (United States)

    Cheng, Ka-Man; Xin, John H.; Taylor, Gail

    2002-06-01

    During the color perception process, an associated feeling or emotion is induced in our brains, and this kind of emotion is termed as 'color emotion.' The researchers in the field of color emotions have put many efforts in quantifying color emotions with the standard color specifications and evaluating the influence of hue, lightness and chroma to the color emotions of human beings. In this study, a color planner was derived according to these findings so that the correlation of color emotions and standard color specifications was clearly indicated. Since people of different nationalities usually have different color emotions as different cultural and traditional backgrounds, the subjects in this study were all native Hong Kong Chinese and the color emotion words were all written in Chinese language in the visual assessments. Through the color planner, the designers from different areas, no matter fashion, graphic, interior or web site etc., can select suitable colors for inducing target color emotions to the customers or product-users since different colors convey different meanings to them. In addition, the designers can enhance the functionality and increase the attractiveness of their designed products by selecting suitable colors.

  18. Scintigraphic acquisition entropy (2). A new approach in the quality control of the scintillation camera performances

    International Nuclear Information System (INIS)

    Elloumi, I.; Bouhdima, M.S.

    2002-01-01

    A new approach in the survey of the performances of gamma camera based on the entropy associated to the scintigraphic acquisition is presented. We take into account the sensitivity, the variation of the collimator response in function of the depth, the uncertainty on the number of counts, the multiplex effect and the spatial uncertainty. This entropy function is expressed in function of all the acquisition parameters: intrinsic crystal resolution, collimator characteristics, emitter object parameters and the source activity. The application of this method to the study of the influence of the collimation shows that the entropy associated to a collimator permits a best appreciation of the quality of the acquisition and therefore a better analysis of collimator performances. Likewise, the evolution of the entropy associated to the acquisition of a uniform source image is in agreement with the variation of the quality of image histogram. One shows, thus, that nor the spatial resolution, nor the sensitivity and nor the signal to noise ratio are able detect a variation of the image quality, when analysed one by one. (author)

  19. Scintigraphic detection of remote transmural myocardial infarction with thallium-201

    International Nuclear Information System (INIS)

    Silber, S.; Fleck, E.; Bierner, M.; Klein, U.; Rudolph, W.

    1979-01-01

    This study was undertaken to assess the value of the thallium-201-scintigram in the detection of remote myocardial infarction with respect to localization and extent as well as the degree of impairment of left ventricular wall motion. 114 patients with typical history of infarction, unequivocal ECG changes and angiographically-documented irreversible asynergy were investigated and 25 healthy subjects served as controls. Electrocardiographic classification of infarction as extensive or non-extensive was based on number of leads involved. The thallium-201-scintigrams were visually analyzed for evaluation of each of 3 segments in all 6 recorded projections. The angiograms were evaluated with respect to regional wall motion derived for the semi-axis shortening of the 3 corresponding scintigraphic segments in the right and left anterior oblique projections. Standard classification of localization and degree of asynergy were employed. (orig.) 891 AJ/orig. 892 MB [de

  20. Preliminary results on scintigraphic evaluation of malignant external otitis

    International Nuclear Information System (INIS)

    Malamitsi, J.; Maragoudakis, P.; Papafragou, K.; Koukouliou, V.; Kalatzis, Y.; Adamopoulos, G.; Proukakis, C.

    1993-01-01

    Malignant external otitis (MEO) is a potentially fatal otitis occurring in diabetic and immunosuppressed patients, which may cause cranial nerve palsies and massive thrombophlebitis of the brain. We studied five diabetic patients with the clinical diagnosis of external otitis who were suspected of having MEO and one diabetic patient presumed cured from MEO. All of them underwent methylene diphosphonate, nanocolloid and gallium single-photon emission tomography studies with quantitative analysis on the basis of regions of interest and count profile curves. This combined assessment helped us to diagnose and follow-up soft tissue and temporal bone infection, especially in the case of transsphenoidal extension of the disease, since conventional radiology and computed tomography were of no particular help. On the basis of these results, we consider scintigraphic demonstration of skull base infection as a fourth criterion of MEO given that the classical Chandler's triad (diabetes, granuloma, and Pseudomonas aeruginosa) is not always present. (orig.)

  1. Scintigraphic findings in amoebic abscess of the liver

    International Nuclear Information System (INIS)

    Buenemann, H.; Petersen, F.; Mohr, W.

    1976-01-01

    The accuracy, size, localization and course of liver scans of solitary or multiple amoebic liver abscesses was evaluated in 52 patients. The scintigraphic data were correlated with the clinical symptoms. In 47 of the 52 patients it was possible to demonstrate the liver abscess on the scintigram; the right lobe of the liver was involved more frequently than would have been expected simply on the basis of its volume. In most of the patients investigated the abscesses were solitary and in only 28% it was possible to recognise two or three abscesses occurring simultaneously. Follow-up examinations showed rapid diminution in the size of the abscess during medical treatment, but complete return to normal during the first six months occured in only 17% of cases. The results are discussed. (orig.) [de

  2. Contribution to scintigraphic study of pulmonary ventilation using 133Xe

    International Nuclear Information System (INIS)

    Chareyron, R.P.

    1975-01-01

    A technique of regional lung function study, using 133 Xe, is described (instrumentation, procedure, results). A gamma-camera is used for this investigation, its main advantages are as follows. The picture is smaller than the one produced by a scanner, but is obtained more quickly. The gamma-camera equipped with a data processing unit is able to visualize areas of interest and to provide quantitative informations. Two parameters are studied. The first one is Xenon washout speed expressed in (ml/mn/cm 3 ) which gives an exact value of pulmonary ventilation. The latter is retention. This parameter is of interest because retention is more easy to evaluate than washout speed, and is able to quantify what is suggested by scintigraphic pictures. The technique has proven to be valuable in differentiating chronic bronchitis from post-bronchitic emphysema [fr

  3. A simple scintigraphic method for continuous monitoring of gastric emptying

    Energy Technology Data Exchange (ETDEWEB)

    Lipp, R.W.; Hammer, H.F.; Schnedl, W.; Dobnig, H.; Passath, A.; Leb, G.; Krejs, G.J. (Graz Univ. (Austria). Div. of Nuclear Medicine and Endocrinology)

    1993-03-01

    A new and simple scintigraphic method for the measurement of gastric emptying was developed and validated. The test meal consists of 200 g potato mash mixed with 0.5 g Dowex 2X8 particles (mesh 20-50) labelled with 37 MBq (1 mCi) technetium-99m. After ingestion of the meal, sequential dynamic 15-s anteroposterior exposures in the supine position are obtained for 90 min. A second recording sequence of 20 min is added after a 30-min interval. The results can be displayed as immediate cine-replay, as time-activity diagrams and/or as acitivty retention values. Complicated mathematical fittings are not necessary. The method lends itself equally to the testing of in- and outpatients. (orig.).

  4. Sjoegren's syndrome. A functional scintigraphic study of salivary glands

    International Nuclear Information System (INIS)

    Arrago, J.P.; Rain, J.D.; Rocher, F.; Vigneron, N.; Pecking, A.; Najean, Y.

    1984-01-01

    One-hundred and twenty patients with sicca syndrome, connective tissue disease or chronic graft-versus-host disease were investigated in the Saint-Louis Hospital Department of Nuclear Medicine. Technetium scanning of the salivary glands was performed in all patients. The results of the scintigraphic study were closely correlated with clinical and histological data in patients with Sjoegren's syndrome. This method, which accurately quantifies the salivary function without danger nor discomfort to the patients, has a number of advantages: (a) it is sensitive enough to detect minimal salivary gland dysfunction; (b) it differentiates between parotid gland and submandibular gland involvement demonstrates assymetry in pathological processes; (c) it helps in following up patients with Sjoegren's disease and in assessing the results of immunosuppressive or anti-inflammatory treatment [fr

  5. Fixing the flaws [Why emergency planners need the public's knowledge

    International Nuclear Information System (INIS)

    Lasker, R.D.

    2007-01-01

    Planners seeking to mitigate the consequences of acts of radiological terrorism - including terrorist attacks on nuclear power infrastructures - are working at a distinct disadvantage. The public is the object of their concern and the focus of their education and risk communication efforts, but strategies and plans are being developed without directly involving the public. Lacking that voice, do we really know what matters to people in these types of situations and what can be done to address the problems they would face? Do we fully appreciate the role that the public can play in contributing to response and recovery? Recent research and experience with disasters in the United States reveal that we don't - with dire consequences

  6. Developing an interactive intervention planner: a systems engineering perspective

    CERN Document Server

    Fabry, Thomas; Feral, Bruno; Braesch, Christian

    2013-01-01

    Intervention planning is crucial for maintenance operations in particle accelerator environments with ionizing radiation, during which the radiation dose received by maintenance workers should be reduced to a minimum. In this context, we discuss the development of a new software tool and the entailed methodology, including the visualization aspects. The software tool integrates interactive exploration of a scene depicting an accelerator facility augmented with residual radiation level simulations, with the visualization of intervention data such as the followed trajectory and maintenance tasks. Its conception allows for future inclusion of measurements performed by mobile robotic devices. In this work, we explore the systems engineering life cycle of the development process of an interactive intervention planner, which includes the needs analysis, specification explicitation, conceptual mathematical modelling, iterative implementation, design and prototype testing and usability testing.

  7. Optimal Path Planner for Mobile Robot in 2D Environment

    Directory of Open Access Journals (Sweden)

    Valeri Kroumov

    2004-06-01

    Full Text Available The problem of path planning for the case of a mobile robot moving in an environment filled with obstacles with known shapes and positions is studied. A path planner based on the genetic algorithm approach, which generates optimal in length path is proposed. The population member paths are generated by another algorithm, which uses for description of the obstacles an artificial annealing neural network and is based on potential field approach. The resulting path is piecewise linear with changing directions at the corners of the obstacles. Because of this feature, the inverse kinematics problems in controlling differential drive robots are simply solved: to drive the robot to some goal pose (x, y, theta, the robot can be spun in place until it is aimed at (x, y, then driven forward until it is at (x, y, and then spun in place until the required goal orientation

  8. Developing an Interactive Intervention Planner - A Systems Engineering Perspective

    Directory of Open Access Journals (Sweden)

    Thomas Fabry

    2013-09-01

    Full Text Available Intervention planning is crucial for maintenance operations in particle accelerator environments with ionizing radiation, during which the radiation dose received by maintenance workers should be reduced to a minimum. In this context, we discuss the development of a new software tool and the entailed methodology, including the visualization aspects. The software tool integrates interactive exploration of a scene depicting an accelerator facility augmented with residual radiation level simulations, with the visualization of intervention data such as the followed trajectory and maintenance tasks. Its conception allows for future inclusion of measurements performed by mobile robotic devices. In this work, we explore the systems engineering life cycle of the development process of an interactive intervention planner, which includes the needs analysis, specification explicitation, conceptual mathematical modelling, iterative implementation, design and prototype testing and usability testing.

  9. Scintigraphic aspect of liver in hepatitis. [/sup 198/Au-radiocolloid

    Energy Technology Data Exchange (ETDEWEB)

    Silva, W M; Medeiros, M [Hospital dos Servidores do Estado, Rio de Janeiro (Brazil). Servico de Medicina Nuclear

    1976-01-01

    A series of scintigraphs was made in a group of 15 patients with viral hepatitis, and compared with biochemical tests. Although in some patients the last biochemical tests were only slightly elevated, and in others entirely normal, they all continued to show abnormal scintigraphs with a mottled aspect and splenic uptake. It is supposed that some sequellae remain in the hepatic tissue even though the patient responds well in clinical and laboratory tests.

  10. Bone stress: a radionuclide imaging perspective

    International Nuclear Information System (INIS)

    Roub, L.W.; Gumerman, L.W.; Hanley, E.N. Jr.; Clark, M.W.; Goodman, M.; Herbert, D.L.

    1979-01-01

    Thirty-five college athletes with lower leg pain underwent radiography and radionuclide studies to rule out a stress fracture. Their asymptomatic extremities and 13 pain-free athletes served as controls. Four main patterns were observed: (a) sharply marginated scintigraphic abnormalities and positive radiographs; (b) sharply marginated scintigraphic abnormalities and negatives radiographs; (c) ill-defined scintigraphic abnormalities and negative radiographs; and (d) negative radionuclide images and negative radiographs. Since the patients with the first two patterns were otherwise identical medically, the authors feel that this scintigraphic appearance is characterisic of bone stress in the appropriate clinical setting, regardless of the radiographic findings. A schema is proposed to explain the occurrence of positive radionuclide images and negative radiographs in the same patient, using a broad conceptual approach to the problem of bone stress

  11. Acute rhabdomyolysis of the soleus muscle induced by a lightning strike: magnetic resonance and scintigraphic findings

    Energy Technology Data Exchange (ETDEWEB)

    Watanabe, Naofumi; Inaoka, Tsutomu; Shuke, Noriyuki; Takahashi, Koji; Aburano, Tamio [Asahikawa Medical College, Department of Radiology, Asahikawa (Japan); Chisato, Naoyuki; Go, Kazutomo [Asahikawa Medical College, Department of Emergency Medicine, Asahikawa (Japan); Nochi, Hitoshi [Asahikawa Medical College, Department of Orthopaedic Surgery, Asahikawa (Japan)

    2007-07-15

    Among natural disasters, a lightning strike is a rare but potentially life-threatening phenomenon. If victims survive a cardiac arrest due to instantaneous passage of an exceptionally high voltage electric charge through the whole body, they may be afflicted with various complications such as muscle necrosis resulting in acute renal failure. In this article, we report a case of a 54-year-old man with acute rhabdomyolysis of the left soleus muscle associated with a lightning strike. T2-weighted and short-tau inversion recovery MR images showed a high signal intensity in the left soleus muscle. A whole-body bone scintigram showed abnormal uptakes in the left soleus muscle and the dorsal aspect of the left foot. MR and scintigraphic evaluations were very useful in depicting the site and extent of muscle damage. Since the patient showed a surprisingly high level of serum creatine kinase, the added information was very valuable for determining the patient's management. (orig.)

  12. Scintigraphic evaluation of brain death with 99mTc-d,l-hexamethyl-propyleneamine oxime (HMPAO)

    International Nuclear Information System (INIS)

    Takehara, Yasuo; Isoda, Haruo; Sakai, Tsuneo; Tanaka, Tokutaro; Sato, Haruhiko; Yamamoto, Takamichi; Takahashi, Motoichiro; Kaneko, Masao.

    1989-01-01

    Lately, the criteria of brain death is being discussed. Cerebral scintigram, especially scintigraphic evaluation of brain death by dynamic study, has been previously reported. Cerebral imaging using radiolabeled amines such as 123 I-IMP N-isopropyl-p-iodoamphetamin (IMP) or 99m Tc d, l-hexamethyl-propyleneamine oxime (HMPAO) offers a significant information of brain death by the finding of 'non visualized brain'. However, the dynamic scintigram acquired during the bolus injection of 99m Tc-HMPAO provides an additional information of brain death by classical 'hot nose sign'. 99m Tc-HMPAO is able to be administered relatively in a large amount of dose. This cerebral perfusion tracer is lipophilic and remains in the central nervous system, which characterize its role as a reliable indicator of cerebral blood flow. As a result, this compound became suitable for the non-invasive study of brain circulation when the diagnosis of brain death is uncertain. We report a case of brain death in which diagnosis was made by the classical 'hot nose sign' in dynamic scintigraphy performed when 99 mTc-HMPAO was injected as well as the SPECT which showed a lack of cerebral visualization at the equilibrium state. As far as we are informed, this additional procedure used in the diagnosis of brain death has not reported before. The importance of performing a dynamic scintigram at the administration of 99m Tc-HMPAO is also discussed in this report. (author)

  13. PopPlanner: Visually constructing demographic models for simulation

    Directory of Open Access Journals (Sweden)

    Gregory Bruce Ewing

    2015-04-01

    Full Text Available Currently there are a number of coalescent simulation programs that support a wide range of features, such as arbitrary demographic models, migration, and sub structure. Defining the model is done typically with either text files or command line switches. Although this has proven to be a powerful method of defining models of high complexity, it is often error prone and difficult to read without familiarity both with command lines and the program in question. A intuitive GUI based population structure program that can both read and write applicable command lines would dramatically simplify the construction, modification, and error checking of such models by a wider user base.Results: PopPlanner is a tool to both construct and inspect complicated demographic models visually with a GUI where the user’s primary interaction is through mouse gestures. Because of their popularity, we focus on ms and by extension msms, command line coalescent simulation programs. Our program can be used to find errors with existing command lines, or to build original command lines. Furthermore the graphical output supports a number of editing and output features including export of publication quality figures.

  14. Clinical, radiographic and scintigraphic aspects of the trapeziometacarpal osteoarthritis; Caracterizacao clinica, radiografica e cintilografica da osteoartrose trapeziometacarpiana

    Energy Technology Data Exchange (ETDEWEB)

    Kaziyama, Helena Hideko Seguchi

    1996-12-31

    Trapeziometacarpal osteoarthritis occurs mainly in women during the menopausal period. It is related to manual activities and is usually bilateral. The onset is insidious and the evolution is slow and progressive. It is characterized by of strength and pain in the basis of the thumb resulting in limitation of the use and function of the hand. The diagnosis of this condition is based on the physical examination. The manouver of compression axial-rotation of the trapezimetacarpal joint is a common positive finding. Typical findings of osteoarthritis are present in the radiological studies. Scintigraphic images have a predictive value. The early diagnosis is important to avoid the risk factors and to prevent disabilities of the hand. (author) 102 refs., 18 figs., 10 tabs.

  15. Clinical, radiographic and scintigraphic aspects of the trapeziometacarpal osteoarthritis; Caracterizacao clinica, radiografica e cintilografica da osteoartrose trapeziometacarpiana

    Energy Technology Data Exchange (ETDEWEB)

    Kaziyama, Helena Hideko Seguchi

    1997-12-31

    Trapeziometacarpal osteoarthritis occurs mainly in women during the menopausal period. It is related to manual activities and is usually bilateral. The onset is insidious and the evolution is slow and progressive. It is characterized by of strength and pain in the basis of the thumb resulting in limitation of the use and function of the hand. The diagnosis of this condition is based on the physical examination. The manouver of compression axial-rotation of the trapezimetacarpal joint is a common positive finding. Typical findings of osteoarthritis are present in the radiological studies. Scintigraphic images have a predictive value. The early diagnosis is important to avoid the risk factors and to prevent disabilities of the hand. (author) 102 refs., 18 figs., 10 tabs.

  16. Scintigraphic measurement of regional gut transit in idiopathic constipation

    International Nuclear Information System (INIS)

    Stivland, T.; Camilleri, M.; Vassallo, M.; Proano, M.; Rath, D.; Brown, M.; Thomforde, G.; Pemberton, J.; Phillips, S.

    1991-01-01

    In this study, total gut transit and regional colonic transit in patients with idiopathic constipation were measured scintigraphically. Eight patients with severe constipation were studied, none of whom had evidence of abnormal function of the pelvic floor. 99mTc-radiolabeled Amberlite resin particles with a mixed meal were used to assess gastric emptying and small bowel transit; similar particles labeled with 111In were ingested in a coated capsule that dispersed in the ileocecal region. These were used to quantify colonic transit. Five healthy volunteers were also studied. Two patients showed delayed gastric emptying and two had slow small bowel transit. Seven of the eight patients had slow colonic transit. In five, delay affected the whole colon (pancolonic inertia); in two, transit in the ascending and transverse colon was normal, but solids moved through the left colon slowly. Mean colonic transit was also measured using radiopaque markers; this technique identified the patients with slow transit, as shown by measurements of overall colonic transit by simultaneous scintigraphy. However, estimated transit through the ascending and transverse colons was considerably shorter by the radiopaque marker technique. In conclusion, idiopathic constipation is characterized by either exaggerated reservoir functions of the ascending and transverse colons and/or impairment of propulsive function in the descending colon. Particle size may influence the result of regional colonic transit tests. Transit delays in other parts of the gut suggest that, in some patients, the condition may be a more generalized motor dysfunction

  17. Scintigraphic measurement of regional gut transit in idiopathic constipation

    Energy Technology Data Exchange (ETDEWEB)

    Stivland, T.; Camilleri, M.; Vassallo, M.; Proano, M.; Rath, D.; Brown, M.; Thomforde, G.; Pemberton, J.; Phillips, S. (Gastroenterology Research Unit, Mayo Clinic, Rochester, Minnesota (USA))

    1991-07-01

    In this study, total gut transit and regional colonic transit in patients with idiopathic constipation were measured scintigraphically. Eight patients with severe constipation were studied, none of whom had evidence of abnormal function of the pelvic floor. 99mTc-radiolabeled Amberlite resin particles with a mixed meal were used to assess gastric emptying and small bowel transit; similar particles labeled with 111In were ingested in a coated capsule that dispersed in the ileocecal region. These were used to quantify colonic transit. Five healthy volunteers were also studied. Two patients showed delayed gastric emptying and two had slow small bowel transit. Seven of the eight patients had slow colonic transit. In five, delay affected the whole colon (pancolonic inertia); in two, transit in the ascending and transverse colon was normal, but solids moved through the left colon slowly. Mean colonic transit was also measured using radiopaque markers; this technique identified the patients with slow transit, as shown by measurements of overall colonic transit by simultaneous scintigraphy. However, estimated transit through the ascending and transverse colons was considerably shorter by the radiopaque marker technique. In conclusion, idiopathic constipation is characterized by either exaggerated reservoir functions of the ascending and transverse colons and/or impairment of propulsive function in the descending colon. Particle size may influence the result of regional colonic transit tests. Transit delays in other parts of the gut suggest that, in some patients, the condition may be a more generalized motor dysfunction.

  18. Pasteurized intercalary autogenous bone graft: radiographic and scintigraphic features

    International Nuclear Information System (INIS)

    Ehara, Shigeru; Tamakawa, Yoshiharu; Nishida, Jun; Shiraishi, Hideo

    2000-01-01

    Objective. Pasteurized autogenous bone graft sterilized at a low temperature (60 C) is one option for reconstruction after resection of bone and soft tissue tumors. The purpose of this investigation was to assess the normal and abnormal radiographic and scintigraphic findings of pasteurized intercalary autogenous bone graft after resection of bone and soft tissue sarcomas.Design. This was a retrospective evaluation of the radiography and bone scintigraphy findings in patients after treatment of bone and soft tissue sarcomas using an intercalary pasteurized autogenous bone graft.Patients. Among 10 consecutive patients, eight had intercalary grafts, and they constitute the subjects of this study. All available radiography and bone scintigraphy findings were reviewed for the healing process and the possibility of complications.Results and conclusions. Healing and incorporation of the graft were observed in five patients during the follow-up, but the other three did not heal satisfactorily. Rapid incorporation of pasteurized autogenous bone graft can be demonstrated by means of radiography and bone scintigraphy. (orig.)

  19. Comparative functional scintigraphic and angiographic examination in pancreas diseases

    International Nuclear Information System (INIS)

    Mendizov, A.; Brilski, V.; Bozhiyanov, A.; Romanova, A.; Mardzhanov, I.; Glavincheva, I.; Meditsinska Akademiya, Sofia

    1979-01-01

    Pancreas scintigraphy with 75 seleno-methionine, pancreocimine-secretine test and selective abdominal angiography was carried out in patients with chronic pancreatitis, pancreas carcinoma and subjects without any pancreas diseases. Scintigraphic changes in pancreas was found in 95,6 per cent of the patients with chronic pancreatitis (136 patients), in 92 per cent of them with pancreas carcinoma (25 patients) and in 53,4 per cent from the subjects without pancreas diseases (30 examined). Pathological changes in pancreatic secretion was found in 93,4 per cent of the patients with chronic pancreatitis (105 patients), in 93,8 per cent of the subjects with pancreas carcinoma (32 patients) and only in 3,9 per cent from the examined without pancreatic diseases. The angiographic examination is informative mainly in case of tumours and cysts of the pancreas. The diagnostic potentialities of the separate methods for pancreas examination were critically assessed. The basic diagnostic problems in pancreas diseases are solved to a great extent with the combined examination with scintigraphy pancreocimine test and angiography (76 patients). (author)

  20. Factors Related to Choosing between the Internet and a Financial Planner

    Science.gov (United States)

    Son, Jiyeon

    2012-01-01

    In this dissertation, I aim to clarify the factors affecting a consumers' choice between the Internet and a financial planner for making saving and investment decisions, based on household production theory. Moreover, I explore the likelihood of an individual being an Internet user (vs. a non-user), a financial planner user (vs. a non-user),…

  1. The influence of the importance of event factors on meeting planner ...

    African Journals Online (AJOL)

    The influence of the importance of event factors on meeting planner satisfaction: A case study of a theme park event business. ... future business. This was done by sending an online survey to 25 regularly visiting meeting planners. This survey ...

  2. Fuels planning: science synthesis and integration; economic uses fact sheet 04: My Fuel Treatment Planner

    Science.gov (United States)

    Rocky Mountain Research Station USDA Forest Service

    2004-01-01

    In the face of rapidly changing public and political attitudes toward fire and fuel planning, one thing remains constant: the fuel planner is ultimately responsible for making decisions on the land. This fact sheet discusses the options for fuel treatments, and the need, development, and use of the MS Excel-based tool, My Fuel Treatment Planner.

  3. Scintigraphic detection of coronary artery thrombi in patients with acute myocardial infarction

    International Nuclear Information System (INIS)

    Fox, K.A.; Bergmann, S.R.; Mathias, C.J.; Powers, W.J.; Siegel, B.A.; Welch, M.J.; Sobel, B.E.

    1984-01-01

    To determine whether coronary thrombi can be detected scintigraphically after acute myocardial infarction, 24 patients were studied with a new method employing indium-111-labeled platelets and technetium-99m-labeled red blood cells. Nine patients with suspected infarction were evaluated initially within 9 hours of the onset of symptoms and again 18 to 24 hours after onset. Foci of net indium accumulation were detected after image processing that incorporated subtraction of blood pool activity. Carotid and pulmonary artery reference regions, in which blood pool activity is high and active platelet deposition unlikely, were used to correct digitized cardiac scintigrams for indium-111 platelet activity in the blood pool. In patients with infarction, distinct foci of net indium accumulation were present in regions corresponding to the coronary artery supplying ischemic zones. This occurred in seven of eight patients at the time of the earliest evaluation after the onset of symptoms) and in eight of nine patients at the time of subsequent imaging (23.6 +/- 1.9 hours after onset). Only 1 of 15 control patients exhibited a cardiac focus of net indium accumulation. The percent of indium excess (100 [total indium-111 activity-blood pool indium-111 activity]/blood pool indium-111 activity) within the cardiac region measured (+/- SD) 16.8 +/- 11.6% in all patients with myocardial infarction (19.1 +/- 11.2% in those with visually identified foci) compared with 0.4 +/- 4.3% in control patients. This method permits early detection and sequential assessment of coronary artery thrombi

  4. Scintigraphic evaluation of the esophageal transit in patients with polymyositis

    International Nuclear Information System (INIS)

    Viterbo, B.G.; Moriguchi, S.M.; Rocha, O.M.; Henry, M.A.C.A.

    2002-01-01

    Aim: To evaluate the esophageal function of patients with polymyositis. Materials and Methods: Nine patients with polymyositis were evaluated, 8 female and 1 male. The ages ranged from 20 to 65 years. Seventeen healthy volunteers (4 female and 13 male) were also evaluated as control group. The median age was 28 years (20 to 41). All patients and controls were submitted to the esophageal scintigraphy performed after the oral ingestion of 37 MBq of stannous colloidal labeled with 99m Tc and diluted in 10 ml of water. The dynamic study was acquired on the supine position, 1 frame/0.5 sec., during 50 sec with a large-field-of-view gamma-camera. Time-activity curves were generated from ROIs positioned over the three portions of the esophagus (upper, middle and distal). The radiotracer retention (RR) after 15 seconds of the peak of radioactivity on the whole esophagus was calculated as a percentage. The pattern of the time-activity curves was classified as normal, as hypomotility or as a mixed pattern, with associated dysmotility. Non-parametric statistical analysis was made with the Mann-Whitney test and the significance level was set at 5%. Results: All the patients with polymyositis presented esophageal motor alterations on the esophageal scintigraphy. Eight (88.9%) patients revealed a mixed pattern at the three segments of the esophagus and 1 (11.1%) patient presented hypomotility at the middle and distal segments. All the healthy volunteers showed normal results at the scintigraphic study. The mean RR of the patients with polymyositis was 69.1% and 4.4% on the control group (P<0.0001). Conclusion: The esophageal transit scintigraphy is a sensitive and useful method to evaluate functional disorders of the esophagus of patients with polymyositis

  5. Scintigraphic method for evaluating reductions in local blood volumes in human extremities

    DEFF Research Database (Denmark)

    Blønd, L; Madsen, Jan Lysgård

    2000-01-01

    in the experiment. Evaluation of one versus two scintigraphic projections, trials for assessment of the reproducibility, a comparison of the scintigraphic method with a water-plethysmographic method and registration of the fractional reduction in blood volume caused by exsanguination as a result of simple elevation......% in the lower limb experiment and 6% in the upper limb experiment. We found a significant relation (r = 0.42, p = 0.018) between the results obtained by the scintigraphic method and the plethysmographic method. In fractions, a mean reduction in blood volume of 0.49+0.14 (2 SD) was found after 1 min of elevation......We introduce a new method for evaluating reductions in local blood volumes in extremities, based on the combined use of autologue injection of 99mTc-radiolabelled erythrocytes and clamping of the limb blood flow by the use of a tourniquet. Twenty-two healthy male volunteers participated...

  6. Scintigraphic detection of metastatic melanoma using indium 111/DTPA conjugated anti-gp240 antibody (ZME-018)

    International Nuclear Information System (INIS)

    Kirkwood, J.M.; Neumann, R.D.; Zoghbi, S.S.; Ernstoff, M.S.; Cornelius, E.A.; Shaw, C.; Ziyadeh, T.; Fine, J.A.; Unger, M.W.

    1987-01-01

    We evaluated the toxicity, pharmacokinetics, and localization of a monoclonal IgG2 alpha murine anti-human melanoma (gp240) antibody (ZME-018) that recognizes a tumor-associated cell surface glycoprotein of 240,000 molecular weight present in most melanomas. The antibody was conjugated with DTPA (diethylenetriamine pentaacetic acid) and labeled by chelation of 111 In. One mg of antibody labeled with 5 mCi of 111 In was infused, together with 0 to 40 mg of cold carrier ZME-018. The blood clearance, urinary excretion, and in vivo localization were determined in 26 patients. Scintigraphic images were obtained at 24 hours and 72 hours in all patients. Mild toxicity occurred in one patient. The half-time clearance of labeled monoclonal murine antibody (MoAb) from the blood increased from 16.1 hours at an antibody dose of 1 mg to 35.9 hours at 40 mg. Males showed faster clearance from the blood than did females or a single castrated male, perhaps due to selective concentration of antibody in the testes. Nonspecific uptake in liver, spleen, bone marrow, and intestine was seen in all patients. The percentage of known metastatic foci detected increased with the total dosage of antibody, from 23% at doses less than or equal to 5 mg, to 65%, 87% and 78% for 10, 20, and 40 mg, respectively. We conclude that at doses of greater than or equal to 10 mg, ZME-018 is a safe and potentially useful agent for the scintigraphic detection of metastatic malignant melanoma

  7. 99m-Tc HMDP bone scintigraphic findings of gouty arthropathy of both hands

    International Nuclear Information System (INIS)

    Shih, Wei-Jen; Domstad, P.A.; Purcell, M.; DeLand, F.H.

    1988-01-01

    The 99m Tc hydroxy methylene diphosphonate scintigraphic findings of both hands are correlated to the radiographic findings in a patient with a 30-year history of gouty arthropathy. Scintigraphic differentiation of the type of arthritis on the basis of uptake pattern is difficult. However, the findings of rheumatoid arthritis are confined to the joints and usually the involvement is symmetrical. With gout there is a tendency toward asymmetrical, bilateral, multifocal joint involvement with areas of intense abnormal uptake; because of the associated soft tissue swelling, the intense uptake usually extends beyond the involved joints. (author)

  8. Robotic and artificial intelligence for keyhole neurosurgery: the ROBOCAST project, a multi-modal autonomous path planner.

    Science.gov (United States)

    De Momi, E; Ferrigno, G

    2010-01-01

    The robot and sensors integration for computer-assisted surgery and therapy (ROBOCAST) project (FP7-ICT-2007-215190) is co-funded by the European Union within the Seventh Framework Programme in the field of information and communication technologies. The ROBOCAST project focuses on robot- and artificial-intelligence-assisted keyhole neurosurgery (tumour biopsy and local drug delivery along straight or turning paths). The goal of this project is to assist surgeons with a robotic system controlled by an intelligent high-level controller (HLC) able to gather and integrate information from the surgeon, from diagnostic images, and from an array of on-field sensors. The HLC integrates pre-operative and intra-operative diagnostics data and measurements, intelligence augmentation, multiple-robot dexterity, and multiple sensory inputs in a closed-loop cooperating scheme including a smart interface for improved haptic immersion and integration. This paper, after the overall architecture description, focuses on the intelligent trajectory planner based on risk estimation and human criticism. The current status of development is reported, and first tests on the planner are shown by using a real image stack and risk descriptor phantom. The advantages of using a fuzzy risk description are given by the possibility of upgrading the knowledge on-field without the intervention of a knowledge engineer.

  9. Low carbon city: A guidebook for city planners and practitioners: Promoting low carbon transport in India

    Energy Technology Data Exchange (ETDEWEB)

    Dhar, S. [Technical Univ. of Denmark. DTU Management Engineering, UNEP Risoe Centre on Energy, Climate and Sustainable Development, DTU Risoe Campus, Roskilde (Denmark); Pathak, M. [CEPT University, Ahmedabad (India); Shukla, P.R. [Indian Institute of Management, Ahmedabad (India)

    2013-08-15

    The principal aim of the guidebook is to provide basic guidance to city level policy makers, urban planners, transport planners and consultants who are collectively referred to as ''city planners'', on: a) How to incorporate globally agreed upon climate change objectives, targets and policies in long-term city level development plans. b) How to align national development and climate change agendas with city level development plans. c) How to delineate win-win options that deliver multiple co-benefits, besides climate change benefits, such as air quality improvement, improved energy access, reduced congestion in the transport system, and improved national energy security. (LN)

  10. The scintigraphic reaction pattern of traumatic bone lesions; Das szintigraphische Reaktionsmuster knoecherner Verletzungen

    Energy Technology Data Exchange (ETDEWEB)

    Spitz, J. [Praxis fuer Nuklearmedizin, Staedtisches Klinikum Wiesbaden (Germany)

    1994-12-01

    The indications for bone scintigraphy in traumatology result: 1. Definite exclusion of bone lesions by normal scintigraphic findings (except for the scull). 2. Unclear result of X-ray or a mismatch between clinical investigation and X-ray result. 3. Screening after multiple injury which leads to the detection of an unknown bone lesion in every second patient. 4. Suspicion of a complicated healting course in cases of doubtful X-ray results. 5. The estimation of relative fracture age. This question always rises, if a pre-existing trauma or morphologic changes in X-ray make a clear diagnosis impossible. The additional information gained by bone scintigraphy is in part exclusive and not to be drawn from any other imaging modality. This renders bone scintigraphy to an important tool in the work up of medico-legal questions in traumatology. (orig.) [Deutsch] Aus den speziellen szintigraphischen Eigenschaften knoecherner Verletzungen ergeben sich die Indikationen fuer die Skelettszintigraphie in der Traumatologie: 1. Ausschluss einer ossaeren Laesion durch einen szintigraphischen Normalbefund (bei Einhaltung eines ausreichenden Abstandes zum Trauma bilden nur die Schaedelknochen eine Ausnahme); 2. ein unklarer Roentgenbefund oder eine Diskrepanz zwischen Klinik, Anamnese und Roentgenbild; 3. das Screening nach Polytrauma, das bei jedem zweiten unfallverletzten Patienten eine zusaetzliche, bis dahin noch nicht bekannte und radiologisch dann nachvollziehbare Fraktur nachweist; 4. der Verdacht auf einen gestoerten Heilungsverlauf, soweit die primaer eingesetzte Roentgendiagnostik keine verbindliche Interpretation erlaubt; 5. die Bestimmung des relativen Frakturalters, die von Bedeutung ist, wenn vorbestehende Unfaelle in der Anamnese oder morphologische Veraenderungen die Interpretation des Roentgenbildes beeintraechtigen. Die mit Hilfe der Skelettszintigraphie erhaltenen Informationen sind zum Teil exklusiv und mit keinem anderen bildgebenden Verfahren so einfach zu

  11. Sensitivity analysis of an optimization-based trajectory planner for autonomous vehicles in urban environments

    Science.gov (United States)

    Hardy, Jason; Campbell, Mark; Miller, Isaac; Schimpf, Brian

    2008-10-01

    The local path planner implemented on Cornell's 2007 DARPA Urban Challenge entry vehicle Skynet utilizes a novel mixture of discrete and continuous path planning steps to facilitate a safe, smooth, and human-like driving behavior. The planner first solves for a feasible path through the local obstacle map using a grid based search algorithm. The resulting path is then refined using a cost-based nonlinear optimization routine with both hard and soft constraints. The behavior of this optimization is influenced by tunable weighting parameters which govern the relative cost contributions assigned to different path characteristics. This paper studies the sensitivity of the vehicle's performance to these path planner weighting parameters using a data driven simulation based on logged data from the National Qualifying Event. The performance of the path planner in both the National Qualifying Event and in the Urban Challenge is also presented and analyzed.

  12. An RRT-Based path planner for use in trajectory imitation

    CSIR Research Space (South Africa)

    Claassens, J

    2010-01-01

    Full Text Available The authors propose a more robust robot programming; by demonstration system planner that produces a reproduction; path which satisfies statistical constraints derived from demonstration; trajectories and avoids obstacles given the freedom; in those...

  13. Educating collaborative planners: the learning potential of multi-actor regional learning environments for planning education

    NARCIS (Netherlands)

    Oonk, C.; Gulikers, J.T.M.; Mulder, M.

    2013-01-01

    Recent changes in planning context, object, subject and approaches characterised by the key words wickedness, collaborative processes and boundary crossing, require a reconsideration of competencies needed for professional planners and evidence for the effectiveness of learning environments in which

  14. Online transit trip planner for small agencies using Google Transit : final deployment package.

    Science.gov (United States)

    2011-09-01

    Google Transit is a public transportation trip planner that enables travelers to obtain information regarding available transit services between a : given origin and given destination. While transit agencies can publish their service information onto...

  15. An Evolutionary Real-Time 3D Route Planner for Aircraft

    Institute of Scientific and Technical Information of China (English)

    郑昌文; 丁明跃; 周成平

    2003-01-01

    A novel evolutionary route planner for aircraft is proposed in this paper. In the new planner, individual candidates are evaluated with respect to the workspace, thus the computation of the configuration space is not required. By using problem-specific chromosome structure and genetic operators, the routes are generated in real time,with different mission constraints such as minimum route leg length and flying altitude, maximum turning angle, maximum climbing/diving angle and route distance constraint taken into account.

  16. Societal Planning: Identifying a New Role for the Transport Planner-Part I

    DEFF Research Database (Denmark)

    Khisty, C. Jotin; Leleur, Steen

    1997-01-01

    concept. The concept is used collectively to point to and explain the many obstacles faced by planners in carrying out planning as prescribed by the well-known Rational Planning Model (RPM). It is concluded that there is a need for the planner to integrate and master in a new role skills both from...... the "hard" quantitative approach as well as the "soft" qualitative one....

  17. The use of fast digital filters for the processing of scintigraphic pictures

    International Nuclear Information System (INIS)

    Grochulski, W.; Penczek, P.

    1982-01-01

    A brief review of typical methods applied in the development of digital filters for the processing of scintigraphic pictures is given. A simple parametrisation of such filters in the frequency domain is proposed and successfully applied in the case of mathematically simulated IAEA phantoms. The FFT algorithm is used. A possible application of the fast Walsh transform is pointed out. (author)

  18. Scintigraphic determination of gastrointestinal transit times. A comparison with breath hydrogen and radiologic methods

    DEFF Research Database (Denmark)

    Madsen, J L; Larsen, N E; Hilsted, J

    1991-01-01

    A scintigraphic method for determination of gastrointestinal transit times was compared with the breath hydrogen test and a multiple-bolus, single-radiograph technique. A close temporal association was found between the caecal appearance of radioactivity and the onset of breath hydrogen excretion...... the breath hydrogen concentration profiles....

  19. Differentiated thyroid carcinoma in a scintigraphically hot nodule: diagnosis and interdisciplinary therapeutical approach

    International Nuclear Information System (INIS)

    Stahl, A.; Hess, U.; Langhammer, H.; Harms, J.; Zwicknagl, M.

    2002-01-01

    A hyperfunctioning differentiated thyroid carcinoma is a rare occurrence. Nevertheless, this diagnosis must be considered in a scintigraphically hot nodule if there is a clinical or sonographic suggestion of malignancy. The case of a 57-year old patient with hyperthyreosis and a scintigraphically hot thyroid nodule is presented. Further evaluation led to the diagnosis of a differentiated thyroid carcinoma with extensive lymph node and pulmonary metastases (pT2b, pN1b, pM1). The scintigraphically hot nodule corresponded to the primary tumor, whereas scintigraphic detection of the lymph node metastases was only possible postoperatively. Extensive resection of the lymph node metastases was achieved by the intraoperative application of a gamma probe (2nd operation). This allowed sufficient uptake of radioiodine in the pulmonary metastases for their detection and subsequent devitalization by radioiodine therapy. Complete elimination of all tumor tissue was documented at a control follow-up after six months. Gamma probe-guided surgery may allow for additional removement of non-palpable lymph node metastases. In selected cases this may optimize the surgical results and thereby facilitate the subsequent radioiodine elimination of advanced differentiated thyroid carcinomas. (author)

  20. Diffuse lung uptake (DLU) on Ga-67 scintigraph: Clinical, radiologic and pathologic correlation

    International Nuclear Information System (INIS)

    Sy, W.M.; Seo, I.S.; Vieira, J.; Zaman, M.

    1985-01-01

    Review, analysis and correlation (clinical, radiologic and pathologic) of 29 consecutive adults (16 drug addicts and/or homosexuals) with DLU on Ga-67 scintigraph were made. Diffuse increased uptake of at least 75% of both lungs was considered as DLU. WFOF cameras were used to obtain 24 to 96 hr. scintigraphs after IV injection of 3-5 mCi of Ga-67 citrate. In 26, tissue diagnosis established: pneumocystis carinii (PC) 15, miliary tuberculosis (TB) 3, sarcoidosis (SR) 3, drug-induced toxicity 2, and toxoplasmosis (TX), primary hyperparathyroidism and nonspecific lymphocytic pneumonia-one each. In two with breast and one with esophageal carcinomas, no lung tissue diagnosis was sought. Concurrent chest x-rays were negative in 16, but in 7/16, lung infiltrate was later documented. An average of 31 days elapsed before x-rays became positive in four with PC, 7 days in two with TB, and 22 days in one with TX. In 13, concurrent x-rays showed lung infiltrate, but in 6, only subtle, localized rather than diffuse infiltrate was noted. Fourteen of 29 had at least two Ga-67 studies. In 12 (7 PC, 2 TB, 3 SR) of 14 whose repeat studies showed significant to total disappearance of DLU, all did well clinically. In two whose initial studies were negative or equivocal, they became clinically worse when the repeat study showed DLU. In three others (2 PC, 1 TX) who died, their single studies recorded intense DLU. DLU on gallium scintigraph indicated a variety of pathology. In 55.2%, gallium scintigraph predated x-ray findings by a few days to weeks. In 20.3%, x-ray findings were only subtle or localized. Scintigraphic changes correlated well with the clinical courses in various diseases

  1. Interpretation of Scintigraphic Changes during Chronic Hepatitis and Cirrhosis of the Liver

    Energy Technology Data Exchange (ETDEWEB)

    Gheorghescu, B.; Jovin, G.; Pavel, D.; Hoanca, O.; Marculescu, Lidia; Suseanu, I.; Sparchez, T. [Centre of Gastroenterology, Bucharest (Romania)

    1969-05-15

    Photoscintigrams in black and white and in colour were made of the liver and the hepatic clearance was determined by colloidal {sup 198}Au (dimensions 25 - 30 {mu}m) in 82 patients suffering from chronic hepatitis or cirrhosis confirmed by clinical, humeral and histological criteria. The most characteristic changes in the liver scintigram, found particularly in the cirrhosis patients, were: atrophy of the right lobe (partial or total), sometimes pseudo tumoral in appearance; pale or in- homogeneous left lobe; presence of two centres of maximum radiocolloid uptake (left lobe and right lobe); and extrahepatic fixation (spleen, bone marrow). The colour recording system provided better information than the monochromatic system in the diagnosis of cirrhosis. Hepatic clearance showed a decrease, especially in cases of cirrhosis characterized by extrahepatic uptake of the radiocolloid. In the opinion of the authors, the height of the radioactivity curve registered in the temporal region is an indication, during the stabilization phase, of extrahepatic fixation of the colloidal gold. Its height (h{sub 2}) is greater in those cases where the scintigram indicated higher uptake in the spleen and bone marrow. The T 1/2 study of {sup 51}Cr-labelled erythrocytes and their sequestration in the spleen was made in 30 patients exhibiting increased extrahepatic uptake of colloidal gold. The sequestration of labelled erythrocytes was observed in patients showing large-scale splenic uptake of the radiocolloid. Some of the patients whose photoscintigrams previously showed atrophy of the lower region of the right lobe of the liver and obvious presence of the spleen received injections of colloidal gold in the spleen. After intrasplenic injection, the authors obtained the same scintigraphic image in cirrhosis patients, with persistence of the colloidal gold in the spleen, whereas the image of the spleen remained normal in normal subjects. This proves the existence of a lamellar

  2. Combined scintigraphic and radiographic diagnosis of bone and joint diseases. Including gamma correction interpretation. 4. rev. and enl. ed.

    Energy Technology Data Exchange (ETDEWEB)

    Bahk, Yong-Whee [Sung Ae General Hospital, Seoul (Korea, Republic of). Dept. of Nuclear Medicine and Radiology

    2013-07-01

    In this fourth edition of Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases, the text has been thoroughly amended, updated, and partially rearranged to reflect the latest advances. In addition to discussing the role of pinhole imaging in the range of disorders previously covered, the new edition pays detailed attention to the novel diagnostic use of gamma correction pinhole bone scan in a broad spectrum of skeletal disorders, including physical, traumatic, and sports injuries, infectious and non-infectious bone diseases, benign and malignant bone tumors, and soft tissue diseases. A large number of state of the art pinhole scans and corroborative CT, MRI, and/or ultrasound images are presented side by side. The book has been enlarged to encompass various new topics, including occult fractures; cervical sprain and whiplash trauma; bone marrow edema; microfractures of trabeculae; evident, gaping, and stress fractures; and differential diagnosis. This new edition will be essential reading for practitioners and researchers in not only nuclear medicine but also radiology, orthopedic surgery, and pathology.

  3. Combined scintigraphic and radiographic diagnosis of bone and joint diseases. Including gamma correction interpretation. 4. rev. and enl. ed.

    International Nuclear Information System (INIS)

    Bahk, Yong-Whee

    2013-01-01

    In this fourth edition of Combined Scintigraphic and Radiographic Diagnosis of Bone and Joint Diseases, the text has been thoroughly amended, updated, and partially rearranged to reflect the latest advances. In addition to discussing the role of pinhole imaging in the range of disorders previously covered, the new edition pays detailed attention to the novel diagnostic use of gamma correction pinhole bone scan in a broad spectrum of skeletal disorders, including physical, traumatic, and sports injuries, infectious and non-infectious bone diseases, benign and malignant bone tumors, and soft tissue diseases. A large number of state of the art pinhole scans and corroborative CT, MRI, and/or ultrasound images are presented side by side. The book has been enlarged to encompass various new topics, including occult fractures; cervical sprain and whiplash trauma; bone marrow edema; microfractures of trabeculae; evident, gaping, and stress fractures; and differential diagnosis. This new edition will be essential reading for practitioners and researchers in not only nuclear medicine but also radiology, orthopedic surgery, and pathology.

  4. Pharyngeal transit time measured by scintigraphic and biomagnetic method; Tempo de transito faringeano medido atraves dos metodos cintilografico e biomagnetico

    Energy Technology Data Exchange (ETDEWEB)

    Miquelin, C.A.; Braga, F.J.H.N.; Baffa, O. [Sao Paulo Univ., Ribeirao Preto, SP (Brazil). Faculdade de Filosofia, Ciencias e Letras. Dept. de Fisica; Dantas, R.O.; Oliveira, R.B. [Faculdade de Medicina de Ribeirao Preto, SP (Brazil)

    1996-12-31

    A comparative evaluation between scintigraphic and biomagnetic method to measure the pharyngeal transit is presented. Three volunteers have been studied. The aliment (yogurt) was labeled with {sup 9}9{sup m} Technetium for the scintigraphic test and with ferrite for the biomagnetic one. The preliminary results indicate a difference between the values obtained, probably due to the biomagnetic detector resolution 3 refs., 2 figs., 1 tab.

  5. Societal Planning: Identifying a New Role for the Transport Planner-Part I

    DEFF Research Database (Denmark)

    Khisty, C. Jotin; Leleur, Steen

    1997-01-01

    concept. The concept is used collectively to point to and explain the many obstacles faced by planners in carrying out planning as prescribed by the well-known Rational Planning Model (RPM). It is concluded that there is a need for the planner to integrate and master in a new role skills both from......It has been amply demonstrated over the last three decades that public planning is subject to rapid change and great uncertainties, both in dealing with political objectives as well as dealing with new technologies. In the paper the notion of "unbounded uncertainty" is set forth as a relevant...

  6. Scintigraphic small intestinal transit time and defaecography in patients with J-pouch

    DEFF Research Database (Denmark)

    Kjær, Mie Dilling; Simonsen, Jane Angel; Hvidsten, Svend

    2015-01-01

    Objective methods for examination of pouch function are warranted for a better understanding of the functional result and treatment of dysfunction. The objective of this study was to evaluate the results of scintigraphic intestinal transit time and defaecography compared to the results of pouch...... function, mucosal condition and a questionnaire on quality of life (QoL). This cross-sectional study included 21 patients. Scintigraphic transit time and defaecography was determined with the use of Tc-99m. Pouch function was assessed by number of bowel movements, pouch volume, and continence. Pouch...... mucosal condition was evaluated by endoscopy and histology. Median transit time was 189 min (105–365). Median ejection fraction at defaecography (EF) was 49% (3–77) and 62% (17–98) after first and second defecation. Median pouch volume was 223 mL (100–360). A median daily stool frequency of nine (4...

  7. Evaluation of radionuclide calibrators and scintigraphic cameras used in nuclear medicine in the Sergipe

    International Nuclear Information System (INIS)

    Lima Ferreira, F.C.; Nascimento Souza, D. do

    2008-01-01

    A quality control program to nuclear medicine services concerns the verification of the efficiency of equipment used to diagnosis and treatment, allow the professional improvement. In this study were assessed the performance of two radionuclide calibrators (activimeters) and of two scintigraphic cameras employed in nuclear medicine in the state of Sergipe, Brazil, according to regulation CNEN -NN-3.05. Additionally, to the radionuclide calibrators it was established a nd characterized an intercomparison of activities measured by different practitioners from standard samples of sealed radioactive sources of 133 Ba and 57 Co. The evaluation of this manufacture object was made thought quality control tests on scintigraphic cameras, such as: test of spatial resolution, tomographic resolution and linearity. The results of the quality control tests were satisfactory and they one can be used as parameter in future evaluations. (author)

  8. Scintigraphic diagnosis of stress-induced incomplete fractures of the proximal tibia

    International Nuclear Information System (INIS)

    Collier, B.D.; Johnson, R.P.; Carrera, G.F.; Akhtar, K.; Isitman, A.T.

    1984-01-01

    Incomplete stress fractures of the proximal tibial diaphysis can be diagnosed by bone scintigraphy. The scintigraphic appearance of incomplete rather than complete tibial stress fractures is apparently reported for the first time in this article. With no treatment other than restricted activity, this injury heals rapidly and completely in 4 to 6 weeks. The major threat to the patient's welfare is unfounded suspicion of tumor or infection which may lead to biopsy or inappropriate therapy

  9. Evolution of scintigraphic renal lesions in children after an episode of acute pyelonephritis

    International Nuclear Information System (INIS)

    Donoso, Gilda; Lagos, Elizabeth; Rosati, Pia; Hevia, Pilar; Cuevas, Karen; Lobo, Gabriel; Perez, Andres; Gutierrez, Daniela

    2012-01-01

    Background: Abnormal Dimercaptosuccinic acid (DMSA) renal scintigraphy performed six months after an acute pyelonephritis (AP) is generally interpreted as scarring. Aim: To perform a follow up of childhood patients showing scintigraphic renal lesions during the acute phase of pyelonephritis (within 7 days from the beginning of fever). Material and Methods: A scintigraphic control was carried out at 5-7 months and, in case of persistent lesions, an additional late scintigraphy at 10-13 months. All patients were followed clinically for one year and those with a relapse of urinary tract infection were excluded from the study. Results: Eighty five patients with a median age of 8 months were included. Among these, the first scintigraphic control was normal in 59 (69%) and abnormal in 26 patients (31%). In five of these 26 patients (5/26:19%-5/85:6%), a considerable regression of the lesions was obvious on the early control, and normalized completely on the late control. When expressing the results in kidney units, 107 showed lesions during the acute phase of infection; 69% was normal at the early control. Thirty three showed lesions persisting at the early control (31%) and 7 out of these 33 (21%) became normal on the late control (7/107: 7%). In total, 25% of the children included in the study (24% of the kidney units) remained with renal sequelae one year after the initial episode of AP. Conclusions: The persistence of scintigraphic lesions six months after an episode of AP, does not necessarily correspond to permanent scars, since normalization can sometimes be observed on late controls

  10. Evaluation of quatitative scintigraphic method in diagnosis of esophagic involvement of Progressive Systemic Sclerosis

    International Nuclear Information System (INIS)

    Von Muehlen, C.A.

    1985-01-01

    Twenty patients with Progressive Systemic Sclerosis are studied by scintigraphic methodology. The esophageal transit method is used for liquid and solid meals. The results are compared with the ones of a control group, without or not gastrintestinal problems but without autoimmune diasese. 99 sup(m)Tc-sulfurcolloid is used as labelling compound. The studies were done in supine and orthostatical position. (M.A.C.) [pt

  11. Scintigraphic measurements of the heart-blood-pool in dialyzed chronic uremic patients

    International Nuclear Information System (INIS)

    Nagy, E.S.; Nemessanyi, Z.; Narai, G.; Szegedi Orvostudomanyi Egyetem; Szegedi Orvostudomanyi Egyetem

    1976-01-01

    The authors have carried out scintigraphic measurements of the heart in order to diagnose the presence of an exudative pericarditis 50 times in 26 dialyzed uremic patients. Within the one year's observation 13 patients had an exudative pericarditis from the beginning on. In 8 cases a regression of the exudation could be observed. The examination has a low risk for the patient and is suitable to demonstrate clinically relevant pericardial liquid accumulation. (orig.) [de

  12. Scintigraphic Methods to Evaluate Alterations of Gastric and Esophageal Functions in Female Obesity

    Directory of Open Access Journals (Sweden)

    Özgür Ömür

    2014-02-01

    Full Text Available Objective: Altered gastrointestinal function has frequently been observed in obese patients. The aim of this study was to investigate the frequency of gastro-esophageal reflux (GER and to determine the alterations of gastric emptying and esophageal transit by scintigraphic methods in obese patients. Methods: Scintigraphic studies of 50 obese female non-diabetic patients who had not received any treatment for weight control were retrospectively reviewed. Mean Body Mass Index (BMI was 34.96±3.04 kg/m² (range:32-39 kg/m². All subjects were submitted to scintigraphic evaluation of esophageal transit, gastro-esophageal reflux, gastric emptying and presence of Helicobacter pylori infection. The data of obese patients were compared with those of sex-age matched 30 non-obese cases who were selected from our clinical archive. Results: In obese group, seventeen (34% patients were found to be GER positive scintigraphically; mean gastric emptying time (t½ was 59.18±30.8 min and the mean esophageal transit time was 8.9±7.2 s. Frequency of positive GER scintigraphy and the mean value of esophageal transit time were significantly higher in obese patients than non-obese control subjects. Gastric emptying time and esophageal transit time values were significantly longer in GER positive obese patients than GER negative ones. There was no statistically significant difference in the frequency of positive C14 urea breath test between obese and non-obese subjects and there were also no statistically significant correlations between BMI, GER, esophageal transit time and gastric emptying time. Conclusion: In our study, 42 of the 50 obese patients had esophago-gastric motility alterations. The significance of these alterations in obesity is not fully understood, but it is believed that these changes could be because of potential contributing factors in the development or maintenance of obesity or changes in eating habits

  13. Three-Phase Bone Scintigraphic Diagnosis of Acute Transient Synovitis

    International Nuclear Information System (INIS)

    Chung, Soo Kyo; Lee, Myung Hee; Kim, Choon Yul; Bahk, Yong Whee

    1985-01-01

    Acute transient synovitis of the hip presents clinically pain and limping. But in the majority of the cases, definite positive findings are not manifest in roentgenogram in its early phase. However radionuclide bone imaging combines with the assessment of vascularization and bone tracer uptake is of great value in solving this diagnostic problem. The materials for this study consisted of 29 children with acute transient synovitis of the hip, characterized by symptoms and physical signs of an arthritis, negative X-ray findings and disappearance of all symptoms and signs within a short period of time. They were twenty males and 9 females and age ranged from 1 to 12 years. We took pelvic roentgenogram in AP and frog-leg views. After intravenous bolus injection of 10 to 15 mCi of 99m Tc-methylene diphosphonate, 24 sequential image of the pelvis was taken at 2-second interval for blood flow study. The scintigrams were made using a gamma camera with high resolution parallel hole collimator. Blood pool imaging was obtained at 2 minutes after tracer administration. After 3 hours, static images were taken and then close-up image of the hip using pin-hole collimator was followed. The results were as follows: 1) Bone scintigram was much more sensitive than conventional roentgenogram in diagnosis of acute transient synovitis of the hip. 2) Three-phase imagings showed increased vascular activities in blood pool scintigrams in 96%. 3) Pin-hole imaging showed increased tracer uptake in the regional bones of the hip, particularly in the medial aspect of femoral head and acetabulum. 4) We confirmed that three-phase imaging reinforced with pin-hale technique were very useful in diagnose of acute transient synovitis of the hip.

  14. Hepatic Scintigraphic Findings of Budd-Chiari Syndrome due to Inferior Vena Caval Obstruction

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sung Hoon; Chung, Soo Kyo; Byun, Jae Young; Lee, Sung Yong; Shinn, Kyung Sub; Kim, Choon Yul; Bahk, Yong Whee [Catholic University College of Medicine, Seoul (Korea, Republic of)

    1988-03-15

    Budd-Chiari syndrome (BCS) is a rare clinical entity characterized by post-sinusoidal portal hypertension caused by the obstruction to the hepatic vein outflow. The diagnosis is suggested by hepatic scintigraphy and is usually confirmed by hepatic venography, inferior vena cavography and biopsy. The scintigraphic finding of BCS caused by the obstruction of main hepatic vein has been reported to consist typically of hypertrophy of the caudate lobe with increased radionuclide accumulation. Such a typical finding has been accounted for by the fact that the venous outflow from the caudate lobe is preserved when the main hepatic vein is obstructed. But usually, the hepatic venous outflow from the caudate lobe is also obstructed in BCS due to inferior vena caval obstruction. So hepatic scintigraphic findings of BCS due to inferior vena caval obstruction show different findings as compared with the BCS due to hepatic vein obstruction. We evaluate the hepatic scintigrams of the 13 cases of BCS due to inferior vena caval obstruction and review the literatures. The results are as follows: 1) We cannot observe the caudate lobe hypertrophy with increased uptake, which is known as a classic finding in BCS due to hepatic vein obstruction. 2) The most prominent hepatic scintigraphic findings of BCS are nonhomogenous uptake in the liver with extrahepatic uptake in the all cases. 3) We can see cold areas at the superior aspect of right hepatic lobe in 7 cases (54%). This is a useful finding suggesting BCS due to inferior vena caval obstruction.

  15. Scintigraphic diagnosis of experimentally induced pericarditis in dogs using 99sup(m)Tc-labelled pyrophosphate

    International Nuclear Information System (INIS)

    Duska, F.; Novak, J.; Vizda, J.; Kubizek, J.; Simon, J.; Veverkova, O.; Karlova Universita, Hradec Kralove

    1981-01-01

    In the present paper the possibilities of scintigraphic diagnosis of experimental pericarditis are discussed. Pericarditis was induced by either talc or formaldehyde intrapericardially. In all animals the administration of talc as well as formaldehyde produced inflammatory changes which were more serious after formaldehyde. The scan of the talc pericarditis was carried out on the 7th day after operation and of the formaldehyde pericarditis on the 3rd, 7th and 14th day. No positive scintigraphic finding was made in any of the experimental animals, apart from a massive incorporation in the operation scars. The counting of radioactive impulses after the exstirpation of the tissue samples confirmed the scintigraphic findings. Statistical evaluation did not reveal any essential difference between the accumulation of the radiopharmaceutical into the pericarditis as well as into the pericardial bag in comparison with the control animals. Although our model does not exactly reflect the situation of patients suffering from pericarditis it may be assumed that pyrophosphate scintigraphy is not suitable for the diagnosis of acute pericarditis in clinical practice. (orig.) [de

  16. Gamma scintigraphic analysis of albumin flux in patients with acute respiratory distress syndrome

    International Nuclear Information System (INIS)

    Sugerman, H.J.; Tatum, J.L.; Burke, T.S.; Strash, A.M.; Glauser, F.L.

    1984-01-01

    Computerized gamma-scintigraphy provides a new method for the analysis of albumin flux in patients with pulmonary permeability edema. In this technique, 10 mCi of 99 mTc -tagged human serum albumin is administered and lung:heart radioactivity ratios are determined. This ratio remains constant unless there is a leak of albumin, when a rising ratio with time, called the ''slope index'' (SI), is seen. Thirty-five scintigraphic studies were obtained in 28 patients by means of a portable computerized gamma-camera. Thirteen of these patients had clinical evidence of the acute respiratory distress syndrome (ARDS) and six had or were recovering from left ventricular induced congestive heart failure (CHF). Five of the patients with CHF and pulmonary capillary wedge pressure (PCWP) below 30 mm Hg had normal scintigraphic studies. The patients with ARDS were found to have significantly higher SIs than patients who did not have, or had recovered from, ARDS. Positive SIs were present from 1 to 8 days following the apparent onset of ARDS in seven studies in five patients. Recovery of gas exchange was associated with a return to a normal SI in four patients. In conclusion, computerized gamma-scintigraphy was a sensitive, noninvasive tool for the detection of a pathologic increase in pulmonary protein flux. Positive scintigraphic findings were associated with significantly impaired gas exchange. The method documented that the leak of albumin in patients with ARDS may last for days but resolves with recovery

  17. The 'fragmented' scintigraphic lung pattern in pulmonary lymphangitic carcinomatosis secondary to breast cancer.

    Science.gov (United States)

    Vattimo, A V; Burroni, L; Bertelli, P; Vella, A; Volterrani, D

    1998-01-01

    Pulmonary lymphangitic carcinomatosis (PLC) is an unusual presentation of diffuse infiltrative lung disease. In this report we present two cases secondary to breast cancer; the diagnosis was made by means of transbronchial lung biopsy or postmortem examination. The goal of this study was to analyze the scintigraphic pattern of pulmonary perfusion performed with technetium-99m macroaggregated albumin (99mTc-MAA) in the hope of achieving improved recognition of PLC and its subsequent diagnosis. Upon admission, both patients underwent routine clinical exams followed by chest X-rays. The second patient also underwent CT examination, and both were ultimately examined using pulmonary perfusion scintigraphy with 99mTc-MAA. In the various exams performed, the most reliable and easily identified diagnostic finding turned out to be a characteristic 'fragmented' lung pattern revealed with the perfusion lung scan. Unfortunately, in both cases the patients' conditions rapidly worsened and death occurred shortly following scintigraphy. We were able to conclude that the recognition of the mentioned fragmented scintigraphic lung pattern may be useful in suspected PLC, whereas the nonspecific clinical presentation of this pathology makes diagnosis extremely difficult, with the most significant results being achieved through a comparison of scintigraphic and high resolution CT data.

  18. Scintigraphic determination of the effect of metoclopramide and morphine on small intestinal transit time

    Energy Technology Data Exchange (ETDEWEB)

    Prokop, E.K.; Caride, V.J.; Winchenbach, K.; Troncale, F.J.; McCallum, R.W.

    1988-01-01

    To determine if a scintigraphic method could detect pharmacologic changes in small intestinal transit time (SITT), 10 male volunteers were studied at baseline and after intravenously administered metoclopramide (10 mg) and morphine (8 mg). Five of these volunteers were studied with the hydrogen breath test method for comparison. For each of the scintigraphic studies, the volunteers were positioned supine under a large-field-of-view gamma camera after ingesting an isosmotic lactulose solution containing 99mtechnetium-diethylenetriaminepentaacetic acid (DTPA). Data were collected and stored in a computer. Both gastric emptying and SITT were determined. SITT was 81 +/- 11 min (mean +/- S.E.M.; N = 10) during baseline studies, was decreased significantly to 50 +/- 6 min (N = 10; P less than 0.01) after metoclopramide, and was increased significantly to 161 +/- 15 min (N = 8; P less than 0.01) after morphine. Baseline mean values were 86.3 +/- 15 min (N = 15) for the hydrogen breath tests, 47 +/- 8 min (N = 5) for metoclopramide, and 183 +/- 16 min (N = 5) for morphine. For gastric emptying, there was no significant difference in percentage emptying at 1 hr for baseline and metochopramide (82 +/- 5% vs. 88 +/- 4%). Morphine prolonged gastric emptying at 1 hr to 63 +/- 8%. We conclude that the scintigraphic method for measuring SITT permits accurate investigation of the pharmacologic effects on intestinal motility and, in addition, may be a useful research and clinical method for SITT determination.

  19. Scintigraphic Small Intestinal Transit Time and Defaecography in Patients with J-Pouch

    Directory of Open Access Journals (Sweden)

    Mie Dilling Kjaer

    2015-10-01

    Full Text Available Objective methods for examination of pouch function are warranted for a better understanding of the functional result and treatment of dysfunction. The objective of this study was to evaluate the results of scintigraphic intestinal transit time and defaecography compared to the results of pouch function, mucosal condition and a questionnaire on quality of life (QoL. This cross-sectional study included 21 patients. Scintigraphic transit time and defaecography was determined with the use of Tc-99m. Pouch function was assessed by number of bowel movements, pouch volume, and continence. Pouch mucosal condition was evaluated by endoscopy and histology. Median transit time was 189 min (105–365. Median ejection fraction at defaecography (EF was 49% (3–77 and 62% (17–98 after first and second defecation. Median pouch volume was 223 mL (100–360. A median daily stool frequency of nine (4–25 was reported and three (14% patients suffered from daytime incontinence. No patients had symptomatic or endoscopic pouchitis; however, the histology showed unspecific inflammation in 19 (90% patients. There was no correlation between transit time, evacuation fraction (EF and pouch function in univariate analysis. However, we found a high body mass index (BMI and a low bowel movement frequency to be associated with a longer transit time by multivariate analysis. Scintigraphic determination of transit time and defaecography are feasible methods in patients with ileal pouch anal anastomosis, but the clinical relevance is yet doubtful.

  20. Hepatic Scintigraphic Findings of Budd-Chiari Syndrome due to Inferior Vena Caval Obstruction

    International Nuclear Information System (INIS)

    Kim, Sung Hoon; Chung, Soo Kyo; Byun, Jae Young; Lee, Sung Yong; Shinn, Kyung Sub; Kim, Choon Yul; Bahk, Yong Whee

    1988-01-01

    Budd-Chiari syndrome (BCS) is a rare clinical entity characterized by post-sinusoidal portal hypertension caused by the obstruction to the hepatic vein outflow. The diagnosis is suggested by hepatic scintigraphy and is usually confirmed by hepatic venography, inferior vena cavography and biopsy. The scintigraphic finding of BCS caused by the obstruction of main hepatic vein has been reported to consist typically of hypertrophy of the caudate lobe with increased radionuclide accumulation. Such a typical finding has been accounted for by the fact that the venous outflow from the caudate lobe is preserved when the main hepatic vein is obstructed. But usually, the hepatic venous outflow from the caudate lobe is also obstructed in BCS due to inferior vena caval obstruction. So hepatic scintigraphic findings of BCS due to inferior vena caval obstruction show different findings as compared with the BCS due to hepatic vein obstruction. We evaluate the hepatic scintigrams of the 13 cases of BCS due to inferior vena caval obstruction and review the literatures. The results are as follows: 1) We cannot observe the caudate lobe hypertrophy with increased uptake, which is known as a classic finding in BCS due to hepatic vein obstruction. 2) The most prominent hepatic scintigraphic findings of BCS are nonhomogenous uptake in the liver with extrahepatic uptake in the all cases. 3) We can see cold areas at the superior aspect of right hepatic lobe in 7 cases (54%). This is a useful finding suggesting BCS due to inferior vena caval obstruction.

  1. Making the best use of our previous results as a clue for interpreting kinetics of scintigraphic agents

    Directory of Open Access Journals (Sweden)

    Tsuyoshi Sato

    2011-08-01

    Full Text Available Up to now, we have performed scintigraphy with 201-thallium chloride (201-TlCl and 99m-Tc-hexakis-2-methoxy-isobutyl-isonitrile (99m-Tc-MIBI for malignant tumors and lymphoscintigraphy with 99m-Tc-rhenium-colloid (99m-Tc-Re and 99m-Tc-human-serum-albumin-diethylene-triamine-penta-acetic-acid (99m-Tc-HSA-D for lymph node metastasis. In this article, we re-evaluated scintigraphic images retrospectively with a hope that the results might be a clue, even if it is small, for dentists to try to improve the accuracy of diagnosis of malignant tumors. From scintigraphy, we obtained the tumor retention index as a factor to estimate the uptake of radioactive agents in tumor cells. Moreover, we estimated transport proteins of Na+/K+-ATPase and permeability-glycoprotein (P-gp expressed on the cell membrane that might regulate the kinetic condition of radioactive agents. Among the tumor retention index, the transport protein and the histopathologic finding of tumors, there were relatively well correlations. The tumor retention index showed a difference clearly between malignant tumor and benign tumor. The transport protein revealed a distinct expression in accordance with the malignancy of tumor, and the uptake clearly depended upon the expression of transport protein. Moreover, the lymph node metastasis was detected well by lymphoscintigraphy with 99m-Tc-Re and 99m-Tc-HSA-D.

  2. Nuclear medicine image and data interchange through e-mail

    Energy Technology Data Exchange (ETDEWEB)

    Lyra, M; Skouroliakou, K; Perris, A; Georgossopoulos, C; Pappas, D [Radiology Department, Athens University, Athens (Greece); Stefanides, C [Pediatric Hospital, Aglaia Kyriakou, Athens (Greece)

    1999-12-31

    Prosperity of easy interchange in every day practice of Nuclear Medicine found its application through the INTERNET media. We use a simple and safe way to interchange images and diagnostic information between the scintigraphic acquisition and processing location and the clinical department in order to improve patient`s health care and young doctor`s education. images and patient reports are transferred and saved through dedicated software to a workstation that transforms y-camera scintigraphic images in a PC readable format. Diagnosis reports and scintigraphic images are incorporated to a database directory in hypertext form. Usual WWW connection gives the possibility of patients` examinations transfer by email attachments as well as interchange of relative comments towards both directions. Cost effective solution has been achieved using standard hard- and soft-ware. Furthermore, both educational files can be downloaded from our department ftp location, by a unique password. (authors) 7 refs., 3 figs.

  3. Nuclear medicine image and data interchange through e-mail

    International Nuclear Information System (INIS)

    Lyra, M.; Skouroliakou, K.; Perris, A.; Georgossopoulos, C.; Pappas, D.; Stefanides, C.

    1998-01-01

    Prosperity of easy interchange in every day practice of Nuclear Medicine found its application through the INTERNET media. We use a simple and safe way to interchange images and diagnostic information between the scintigraphic acquisition and processing location and the clinical department in order to improve patient's health care and young doctor's education. images and patient reports are transferred and saved through dedicated software to a workstation that transforms y-camera scintigraphic images in a PC readable format. Diagnosis reports and scintigraphic images are incorporated to a database directory in hypertext form. Usual WWW connection gives the possibility of patients' examinations transfer by email attachments as well as interchange of relative comments towards both directions. Cost effective solution has been achieved using standard hard- and soft-ware. Furthermore, both educational files can be downloaded from our department ftp location, by a unique password. (authors)

  4. Waste Reduction Model (WARM) Resources for State and Local Government/Solid Waste Planners

    Science.gov (United States)

    This page provides a brief overview of how EPA’s Waste Reduction Model (WARM) can be used by state and local government/solid waste planners. The page includes a brief summary of uses of WARM for the audience and links to other resources.

  5. Web-Based Geographic Information Systems: Experience and Perspectives of Planners and the Implications for Extension

    Science.gov (United States)

    Göçmen, Z. Asligül

    2016-01-01

    Web-based geographic information system (GIS) technology, or web-based GIS, offers many opportunities for public planners and Extension educators who have limited GIS backgrounds or resources. However, investigation of its use in planning has been limited. The study described here examined the use of web-based GIS by public planning agencies. A…

  6. The knowledge dynamics of organizational innovation : understanding the implementation of decision support for planners

    NARCIS (Netherlands)

    Sjarbaini, Vivyane Larissa Ratna Nirma

    2009-01-01

    This thesis argues that a knowledge perspective on organizational innovation provides essential insights. A cognitive-semiotic model on knowledge dynamics is presented and used to perform an empirical study. We seek an answer to the question: What happens to the knowledge of planners during an

  7. Strategic operations planning - it's not just for wilderness! How the Strategic Operations Planner can help

    Science.gov (United States)

    Charles W. McHugh; Stu Hoyt; Brett Fay

    2015-01-01

    The Strategic Operational Planner (SOPL) wildland fire management position was created in the United States in 2009 to reflect updated terminology. SOPL merges the former Fire Use Manager positions (FUM1 and FUM2) and is now an established position within the Incident Command System. Traditionally, the FUM positions and the SOPL have been used on incidents managed for...

  8. Planning of undefined becoming : First encounters of planners beyond the plan

    NARCIS (Netherlands)

    de Roo, Gert; Boelens, Luuk

    2014-01-01

    Since the 1980s and due to the ongoing complexity and diffuseness of global networked societies, planners have tried to move beyond classic technocratic and/or sociocratic ideas of planning towards new approaches, which address the multiplicity and fuzziness of our perceptions and actions in time

  9. History, Language Planners, and Strategies of Forgetting: The Problem of Consciousness in the Philippines.

    Science.gov (United States)

    Tupas, T. Ruanni F.

    2003-01-01

    Examines why language planners in the Philippines argue the way they do concerning critical language issues in the country. Suggests discursive "strategies of forgetting" are employed across complex structures of relations shaped by decades of colonialization, Filipino elite collaboration, and current neocolonial and global conditions.…

  10. December 1993 National Drunk and Drugged Driving (3D) Prevention Month: Program Planner.

    Science.gov (United States)

    National Highway Traffic Safety Administration (DOT), Washington, DC.

    This program planner's kit is based on the experiences of the first 12 years of the National Drunk and Drugged Driving (3D) Prevention Month program and provides practical advice to help readers plan activities for this year's campaign. Included in the kit is a background and resource guide that explains the background and goals of the program and…

  11. Scintigraphic appearance and selective arteriographic aspects in intrahepatic cholestasis

    Energy Technology Data Exchange (ETDEWEB)

    Valleteau de Moulliac, M [Hopital Saint-Michel, 75 - Paris (France); de Tovar, G; Mornet, P; Moinard, J F [Centre Medico-Chirurgical Foch, 92 - Suresnes (France)

    1978-01-21

    Based on one case history, it is reviewed that prolonged cases of obstructive jaundice can take on deceiving appearances, and all the more so when they fall within the framework of a 'biological gap'. Extensive distension of the extra and intrahepatic bile ducts are at the basis of images with multiple, radiating hilar gaps on scintigraphy, and of 'chicken nests' and 'Swiss cheese' at hepatographic times in selective hepatic arteriography. These rather uncommon images should lead to a diagnosis of a surgical cholestatic liver.

  12. Evaluation of radiolabelled annexin A5 for scintigraphic imaging of cell processes (necrosis/apoptosis) in cardiovascular diseases; Evaluation de radiotraceurs derives de l'annexine A5 pour l'imagerie scintigraphique de processus cellulaires (apoptose/necrose/thrombose) en pathologie cardiovasculaire (Ressource electronique)

    Energy Technology Data Exchange (ETDEWEB)

    Sarda-Mantel, L

    2007-03-15

    Annexin A5, a 35KDa protein, specifically binds with high affinity to phosphatidylserine (P.S.) which is actively redistributed to the external leaflet of plasmic membranes in apoptotic cells and activated platelets. Annexin A5 radiolabelled with {sup 99m}Tc({sup 99m}Tc-ANX5) was developed by Strauss (stanford, Usa) to image apoptosis in vivo: tumours cells apoptosis induced by chemo-radiotherapy, ischemia/reperfusion lesions in animals and patients, graft rejection. Additionally, many in vitro data suggest that annexin A5 also stains necrosis (membrane disruption), which occurs in all types of cell death. This preclinical work aimed to evaluate the potential interest of {sup 99m}Tc-ANX5 imaging as a clinical tool in cardiovascular diseases. Four studies performed in rat models of myocardial infarction by coronary ligation and ischemia-reperfusion, and in rat models of subacute and acute (isoproterenol-induced) myocarditis show the ability of {sup 99m}Tc-ANX5 to detect in vivo cardio myocytes death by apoptosis and necrosis. Another study demonstrates that {sup 99m}Tc-ANX5 is highly accurate to evaluate in vivo the biological activity of parietal thrombus in a rat model of elastase-induced abdominal aortic aneurysm. These results suggest that {sup 99m}Tc-ANX5 imaging could be used in patients for non invasive diagnosis, prognostic evaluation in acute myocarditis and in various thrombotic cardiovascular diseases. (author)

  13. Osseous sarcoidosis. A case report with scintigraphic consideration

    Energy Technology Data Exchange (ETDEWEB)

    Tonami, H; Miyamura, T; Okumura, T; Yamamoto, I; Nishiki, T [Kanazawa Medical Univ., Ishikawa (Japan)

    1981-12-01

    We presented a case of osseous sarcoidosis which demonstrated abnormal uptake on bone scintigram and /sup 67/Ga scintigram and comparative studies between routine radiographs of bone and RI imagings were done. The results showed that bone scintigram is more sensitive than routine radiographs and it was stressed that bone scintigram should precede radiographic skeletal survey. The significance of abnormal uptake on /sup 67/Ga scintigram seems to need further investigation.

  14. Lymphoscintigraphy (LS) in infants and children: techniques and scintigraphic patterns

    International Nuclear Information System (INIS)

    Somerville, J.; Parsons, G.; Howman-Giles, R.; Lewis, G.; Uren, R.; Mansberg, R.

    1999-01-01

    Full text: Radionuclide imaging of the lymphatic system with intradermal injection of radiopharmaceutical is a rapid, safe and simple technique for the evaluation of lymphatic abnormalities in infants and children. 99 Tc m -antimony sulphide colloid is the agent of choice. The radiopharmaceutical (dose 5 mBq in 0.1 ml) is injected intradermally into both limbs being investigated. Emla cream is useful to reduce the initial discomfort of the injection. Imaging is performed immediately for approximately 30-60 min to assess the flow rate and lymph channels to the draining node fields. Further imaging at 2 and 4 h may be necessary. Normal LS in the lower limbs shows the tracer to pass into lymphatics almost immediately and channels are usually visualized within 5 min. In the lower limbs, symmetrical lymph flow to nodes are seen in the groin, iliac and paravertebral region with activity later seen in the liver. In 31 patients studied over the last 3 years, 17 studies were normal and 14 were abnormal: Klippel-Trenaunay-Weber syndrome (n = 4) with delayed flow and dermal backflow; congenital lymph/vascular malformations (n = 6) with various delayed flow patterns and focal accumulations; congenital lymphoedema (n 3) and pulmonary lymphangiectasia (n = 1). Aplasia and hypoplasia of lymph systems are readily identified. In conclusion, LS is a valuable diagnostic technique to assess lymph flow and diagnose lymphatic malformations and the causes of lymphoedema in children

  15. Spreading of suppository bases assessed with histological and scintigraphic techniques

    International Nuclear Information System (INIS)

    Tupper, C.H.; Copping, N.; Thomas, N.W.; Wilson, C.G.

    1982-01-01

    Suppositories of PEG 15400 and PEG 600, Myrj 52 and Brij 35, were administered rectally to fasted male rats. 30 and 60 mins after liquefaction time samples of rectal mucosa were taken from treated and untreated rats. The reduction in rectal cell volume and density in treated rats was noted. Similar suppositories, containing anion exchange resin and labelled with technetium 99, were administered to other rats. Serial scintiscanning was carried out using a gamma camera linked to a computer. Spreading of the suppository bases was assessed histologically and by imaging. (U.K.)

  16. Parametric and factor analyses of dynamic scintigraphic studies

    International Nuclear Information System (INIS)

    Surova, H.; Samal, M.; Karny, M.

    1986-01-01

    Processing dynamic examinations in nuclear medicine is done as a rule with regard to the regions of interest and dynamic curves or by means of parametric images. The disadvantage of both methods is the processing of the summation of all processes in overlapping anatomical structures. This disadvantage is eliminated by processing using factor analysis. A different approach from those used formerly makes it possible to use information relating to both time and space, as well as direct quantification of the results in imp./pix./sec. (author)

  17. Simplified scintigraphic methods for measuring gastrointestinal transit times

    DEFF Research Database (Denmark)

    Graff, J; Brinch, K; Madsen, Jan Lysgård

    2000-01-01

    . After ingestion of a meal containing 111indium-labelled water and 99mtechnetium-labelled omelette, imaging was performed at intervals of 30 min until all radioactivity was located in the colon and henceforth at intervals of 24 h until all radioactivity had cleared from the colon. Gastric, small...... intestinal and colonic mean transit times were calculated for both markers and compared with fractional gastric emptying at 2 h, fractional colonic filling at 4 h, and geometric centre of colonic content at 24 h, respectively. Highly significant correlations were found between gastric mean transit time...... and fractional gastric emptying at 2 h (111In: r=0.95, P

  18. ERP application of real-time vdc-enabled last planner system for planning reliability improvement

    DEFF Research Database (Denmark)

    Cho, S.; Sørensen, Kristian Birch; Fischer, M.

    2009-01-01

    The Last Planner System (LPS) has since its introduction in 1994 become a widely used method of AEC practitioners for improvement of planning reliability and tracking and monitoring of project progress. However, the observations presented in this paper indicate that the last planners...... and coordinators are in need of a new system that integrates the existing LPS with Virtual Design and Construction (VDC), Enterprise Resource Planning (ERP) systems, and automatic object identification by means of Radio Frequency Identification (RFID) technology. This is because current practice of the LPS...... implementations is guesswork-driven, textual report-generated, hand-updated, and even interpersonal trust-oriented, resulting in less accurate and reliable plans. This research introduces a prototype development of the VREL (VDC + RFID + ERP + LPS) integration to generate a real-time updated cost + physical...

  19. Simplified scintigraphic methods for measuring gastrointestinal transit times

    DEFF Research Database (Denmark)

    Graff, J; Brinch, K; Madsen, Jan Lysgård

    2000-01-01

    To investigate whether simple transit measurements based on scintigraphy performed only 0, 2, 4 and 24 h after intake of a radiolabelled meal can be used to predict the mean transit time values for the stomach, the small intestine, and the colon, a study was conducted in 16 healthy volunteers....... After ingestion of a meal containing 111indium-labelled water and 99mtechnetium-labelled omelette, imaging was performed at intervals of 30 min until all radioactivity was located in the colon and henceforth at intervals of 24 h until all radioactivity had cleared from the colon. Gastric, small...... intestinal and colonic mean transit times were calculated for both markers and compared with fractional gastric emptying at 2 h, fractional colonic filling at 4 h, and geometric centre of colonic content at 24 h, respectively. Highly significant correlations were found between gastric mean transit time...

  20. Open data for informal settlements: Toward a user׳s guide for urban managers and planners

    Directory of Open Access Journals (Sweden)

    Arnab Chakraborty

    2015-12-01

    Full Text Available Informal settlements exist in a legally contested space and the quality of – and access to – information about them has been historically limited. The open data movement promises to address this gap by offering alternative sources for information and free or low cost analytical platforms. However, in order to use open data effectively, urban managers and planners need guidance to navigate these new data sources, software, and server platforms, as well as acquire the necessary skills. In this paper, we begin to address these issues by developing a framework that organizes the sprawling and rapidly evolving world of open urban data. Our framework includes three broad categories (1 inputs and resources, (2 activities and outputs, and (3 outcomes. We then identify and describe the key subcomponents under each, and list the prominent products and resources available to urban managers and planners. For example, under inputs and resources, we discuss open urban data sources such as Open Street Maps, cyberinfrastructure for web hosting, application deployment, and data processing, and open source software that can be used to analyze and visualize collected or derived data. We also identify the key resources available to planners for training and discuss the complementary opportunities presented by conventional datasets such as census and open urban data. Finally, using examples from ongoing activities in Mumbai, we show how open data resources can be useful for understanding urbanization and better integrating informal settlements into formal urban management and planning processes. We suggest that urban managers and planners working in informal settlements should take greater advantage of open data resources in order to both better address current challenges as well as for shaping a better future for the communities they serve.

  1. Societal Planning: Identifying a New Role for the Transport Planner-Part II: Planning Guidelines

    DEFF Research Database (Denmark)

    Khisty, C. Jotin; Leleur, Steen

    1997-01-01

    The paper seeks to formulate planning guidelines based on Habermas's theory of communicative action. Specifically, this has led to the formulation of a set of four planning validity claims concerned to four types of planning guidelines concerning adequacy, dependency, suitability and adaptability......-a-vis the planning validity claims. Among other things the contingency of this process is outlined. It is concluded (part I & II) that transport planners can conveniently utilize the guidelines in their professional practice, tailored to their particular settings....

  2. Coordination activities of human planners during rescheduling: Case analysis and event handling procedure

    OpenAIRE

    2010-01-01

    Abstract This paper addresses the process of event handling and rescheduling in manufacturing practice. Firms are confronted with many diverse events, like new or changed orders, machine breakdowns, and material shortages. These events influence the feasibility and optimality of schedules, and thus induce rescheduling. In many manufacturing firms, schedules are created by several human planners. Coordination between them is needed to respond to events adequately. In this paper,...

  3. Development of a Response Planner using the UCT Algorithm for Cyber Defense

    Science.gov (United States)

    2013-03-01

    President Obama as “one of the most serious economic and national security challenges we face as a nation, but one that we as a government, or as a country...an expensive, exhaustive search. Some other data sets, similar to KDD 99, used with the SFS feature selection algorithm include the Auckland -VI, NZIXII...complex task, but there has been advancements that help guide the searching of these state-based planners to make them faster. Some state-based

  4. Contribution of different scintigraphic techniques to the management of medullary thyroid carcinoma

    International Nuclear Information System (INIS)

    Sandrock, D.; Blossey, H.C.; Steinroeder, M.; Munz, D.L.

    1989-01-01

    We compared three different scintigraphic techniques for the localization of neck recurrences and metastases in seven patients with medullary thyroid carcinoma one month to eight years after the first surgical intervention. Three successive scintigraphic studies were performed in five patients (6 x 3 studies) within two weeks using 201Tl chloride, 111In-labeled F(ab')2 fragments of the anti-carcinoembryonic antigen (anti-CEA) monoclonal antibody (MoAb) BW 431/31, and 131I meta-iodo-benzylguanidine (MIBG). Additionally, 11 studies were performed with the 111In-labeled MoAb fragment BW 431/31 (seven studies) or the 99mTc-labeled intact anti-CEA MoAb BW 431/26 (four studies). The gold standards for classifying scintigraphic results were biopsy, histology, surgery, and cytology. Six regions were classified as positive or negative in each study: thyroid region, four quadrants (lymph node regions) around the thyroid, and the region of the upper mediastinum. Of 36 sites, 201Tl was true positive (TP) in seven sites, false-positive (FP) in one site, true negative (TN) in 22 sites, and false-negative (FN) in six sites, resulting in a sensitivity of 54% and a specificity of 96%. 131I MIBG was TP in four sites, FP in none of the sites, TN in 23 sites, and FN in nine sites, with a sensitivity of 31% and a specificity of 100%. Immunoscintigraphy (102 sites overall) was TP in 16 sites, FP in five sites, TN in 77 sites, and FN in four sites, resulting in a sensitivity of 80% and a specificity of 94%. Immunoscintigraphy with 111In/99mTc anti-CEA F(ab')2 fragment/intact antibody is superior to scintigraphy with 201Tl and 131I MIBG

  5. Comparing imaging procedures: techniques and examples. Gastroenterology

    International Nuclear Information System (INIS)

    Malmud, L.S.

    1982-01-01

    The distinct advantages of nuclear medicine procedures, in comparison to radiography, contrast studies, computerized tomography and ultrasound, are emphasized. Scintigraphic methods offer quantitative data regarding function which competing imaging modalities are unable to provide, and make them the studies of choice in the evaluation of gastrointestinal physiology and functional abnormalities

  6. Automated Trajectory Planner of Industrial Robot for Pick-and-Place Task

    Directory of Open Access Journals (Sweden)

    S. Saravana Perumaal

    2013-02-01

    Full Text Available Industrial robots, due to their great speed, precision and cost-effectiveness in repetitive tasks, now tend to be used in place of human workers in automated manufacturing systems. In particular, they perform the pick-and-place operation, a non-value-added activity which at the same time cannot be eliminated. Hence, minimum time is an important consideration for economic reasons in the trajectory planning system of the manipulator. The trajectory should also be smooth to handle parts precisely in applications such as semiconductor manufacturing, processing and handling of chemicals and medicines, and fluid and aerosol deposition. In this paper, an automated trajectory planner is proposed to determine a smooth, minimum-time and collision-free trajectory for the pick-and-place operations of a 6-DOF robotic manipulator in the presence of an obstacle. Subsequently, it also proposes an algorithm for the jerk-bounded Synchronized Trigonometric S-curve Trajectory (STST and the ‘forbidden-sphere’ technique to avoid the obstacle. The proposed planner is demonstrated with suitable examples and comparisons. The experiments show that the proposed planner is capable of providing a smoother trajectory than the cubic spline based trajectory.

  7. Principle and preliminary results of the whole-body scintigraphic unit Omniview

    International Nuclear Information System (INIS)

    Methlin, G.; Jung, G.M.; Gerard, G.

    The Picker Company has recently launched a system adapted to its Dynacamera for the production of whole-body scintigraphs. For the last few months the radioisotopes service of the Strasbourg Anti-Cancer Centre has been in possession of such a system, intended mainly for systematic research on metastases, especially of the bone, and on the degree of extension of tumours. On the basis of the short experience so far acquired the report is limited to an outline of the working principle of this device, the presentation of preliminary documents and a few critical remarks summing up first impressions [fr

  8. Scintigraphic hepatobiliary function studies in newborn infants to diagnose biliary hypoplasia or atresia

    International Nuclear Information System (INIS)

    Askari-Sabi, Z.

    1987-01-01

    The results obtained from scintigraphic hepatobiliary function studies, intraoperative cholangiography and histological examinations in a total of 17 infants suspected of having biliary atresia were compared and analysed with reference to the clinical signs and symptoms observed. In most cases, the individual diagnostic procedures led to consistent findings, even though there were some variations in the clinical picture. Patient outcome is largely determined by the site of atresia, due to which fact surgical correction should be carried out as soon as possible, in any case before the 8th week post partum. (TRV) [de

  9. Scintigraphic measurements of gastric emptying corrected for differences in tissue attenuation

    Energy Technology Data Exchange (ETDEWEB)

    Lauritzen, J.B.; Hoejgaard, L.; Uhrenholdt, A. (Copenhagen Univ. (Denmark). Hvidovre Hospital)

    1983-10-01

    In order to evaluate the importance of variations in tissue attenuation in scintigraphic measurements of gastric emptying, both in vivo and in vitro measurements of count rates from an encapsulated sup(99m)Tc dose were performed in different parts of the stomach. The obtained individual tissue correction factors were applied in the calculation of gastric emptying rates by gamma camera in healthy volunteers. The results showed that the anterior gamma camera scan without correction for differences in tissue attenuation underestimated the gastric emptying rate by 11% if the results were expressed as percentage meal emptied over 60 minutes.

  10. Scintigraphic study of blood perfusion of the pulmonary artery in pulmonary tuberculosis

    International Nuclear Information System (INIS)

    Certain, D.A.; Brolio, R.; Salomon, G.C.; Carvalho, N.; Barbosa, Z.L.M.

    1972-01-01

    Blood perfusion in the pulmonary artery is studied by pulmonary scintigraphy with macroaggregated albumin 131 I, in 74 cases of pulmonary tuberculosis. Results shown by scintigraphy are compared to those observed in roentgenography and also correlated with the extension and degree of the lesions, and with the presence of associated tuberculosis, considered capable of changing the scintigraphic picture. The reduction of blood flow in the pulmonary artery are observed in cases of infiltrative, fibrotic of caseous lesions, as well as in cases of minor lesions [pt

  11. Scintigraphic study of blood perfusion of the pulmonary artery in pulmonary tuberculosis

    Energy Technology Data Exchange (ETDEWEB)

    Certain, D A; Brolio, R; Salomon, G C [Sao Paulo Univ. (Brazil). Faculdade de Saude Publica; Carvalho, N [Sao Paulo Univ. (Brazil). Centro de Medicina Nuclear; Barbosa, Z L.M. [Associacao dos Sanatorios Populares de Campos do Jordao, Brazil

    1972-10-01

    Blood perfusion in the pulmonary artery is studied by pulmonary scintigraphy with macroaggregated albumin /sup 131/I, in 74 cases of pulmonary tuberculosis. Results shown by scintigraphy are compared to those observed in roentgenography and also correlated with the extension and degree of the lesions, and with the presence of associated tuberculosis, considered capable of changing the scintigraphic picture. The reduction of blood flow in the pulmonary artery are observed in cases of infiltrative, fibrotic of caseous lesions, as well as in cases of minor lesions.

  12. Parallel scintigraphic and echographic studies in patients with miscellaneous andrologic diseases

    International Nuclear Information System (INIS)

    Sultanov, S.; Stanchev, P.; Tsvetkov, D.

    1989-01-01

    The diagnostic possibilities of scintigraphic and echographic methods are compared for diagnostics of varicocele, cryptorchidism, orchiepididymitis, atrophy of the testis, post orchidopexy state, tumors, torsion and hypogonadism. A nonselected group of 33 patients is studied. In 24 patients was coincidence in the results from gamma camera scintigraphy and echography, in 7 - lack of coincidence and in 3 - partial coincidence. It is concludied that the two methods are quick, exact and noninvasive. Gamma-camera scintigraphy is especially suitable for torsion, where the diagnosis is infallible, for cryptorchidism, varicocele and for tumors, where the necrotic zones in the testis are very precisely visualized. 3 figs., 4 refs

  13. 99mTc DMSA scintigraphic findings in renal tuberculosis

    International Nuclear Information System (INIS)

    Moon, Tae Yong; Kim, Kun Il; Yoon, Chi Soon; Lee, Suck Hong; Kim, Byung Soo

    1993-01-01

    Evaluations of residual renal function and the therapeutic effectiveness in renal tuberculosis have largely been dependent on intravenous pyelogram or Contrast-CT scan, even though, exact renal functions are not evaluate with there methods. 99m Tc- DMSA is a radiopharmaceutical that is trapped in the functioning tubular cells of the kidney and therefore, quantitative renal function could be evaluated by insuring the counts of renal radioactivity and concomitant evaluation of renal morphology could be passable with the analog images of the radioactivity. The authors retrospectively analyzed 99mTc-DMSA scans of 75 kidneys of 67 patients with confirmed renal tuberculosis. We classified the morphologies of tuberculous kidneys as 6 types. We classified the morphologies of tuberculous kidneys as 6 types such as the type with small cortical defect, with parenchymal ulcerocavernous lesions, ulcerocavernous fistula to pelvis, mass-like defects, contracted kidney with ureter visualization, and the type with non visualization of kidney, corresponding to the characters of renal tuberculous pathogenesis with abscess formation, ulcerocavernous fistula, and fibrosis, and corresponding to the renal anatomy with parenchyma, and pelvocalyceal collecting system. Their mean residual renal functions measured with 99mTc-DMSA uptake rates were 19.0%,18.4%, 7.9%, 12%, 4.1%, 3.4% respectively

  14. A new scintigraphic technique for assessment of right atrial function

    International Nuclear Information System (INIS)

    Marmor, A.; Biello, D.R.; Sampathkumaran, K.S.; Geltman, E.M.; Siegel, B.A.; Roberts, R.

    1981-01-01

    Gated radionuclide imaging with 99 mTc-labeled red blood cells was employed to assess changes in right atrial (RA) volume in 17 subjects. Studies were repeated within two hours in five of 12 normal subjects and at two and ten days after infarction in five patients. Time-activity curves were generated for the RA and right ventricle (RV) from variable regions of interest defined by automatic edge detection. The RA time-activity curve exhibited four phases: filling, early emptying, equilibration, and late emptying. Repeated measurements of RA early emptying rates correlated closely in normals (r . 0.93). Early RA emptying and RV filling rates corresponded closely (r . 0.89). In four patients with infarction, the RA emptying rate was slowed on the first study but had normalized by 10 days. In a patient with inferior infarction and suspected RV infarction, the RA emptying rate was depressed and remained so for 10 days. Thus, relative changes in right atrial volume can be assessed reproducibly by a radionuclide technique, which is relatively independent of geometric assumptions. This technique offers great promise as a method to assess atrial function in health and disease

  15. 99m-Tc-IDA scintigraphic demonstrability of biliary elements and liver function tests in hepatobiliary diseases

    International Nuclear Information System (INIS)

    Kim, C.Y.; Bahk, Y.W.

    1982-01-01

    In the present communication, the results will be reported on a clinical study of how well scintigraphic visualization of the hepatobiliary elements and several commonly used clinical liver function tests correlate each other in various diseases of the hepatobiliary system. The demonstrability of the biliary tract, gallblader (GB) and duodenum was rather closely paralleled to serum bilirubin level and less closely to alkaline phosphatase and rather poorly to SGOT and SGPT. The biliary tree could not be visualized scintigraphically when bilirubin exceeded 10 mg/dl

  16. Scintigraphic assessment of Barrett's esophagus

    Energy Technology Data Exchange (ETDEWEB)

    Kotler, J.A.; Sampliner, R.E.; Kogan, F.J.; Henry, R.E.; Mason, B.F.

    1984-01-01

    Barrett's (B) esophagus is defined by the presence of columnar epithelium above the gastroesophageal junction. Patients with 5cm histologically proven B were evaluated for mucosal labeling (ML), esophageal motility (EM), gastroesophageal reflux (GER), and gastric emptying (GE) of solids and liquids with and without iv metaclopramide (MCP). ML, after premedication with cimetidine, was evaluated 20 and 40 min after injection of Tc-99m04 with ANT and RAO views. Eight of 11 B and 0 of 2 controls (C) labeled esophageal mucosa. EM was assessed in the supine position over one min after a 15 ml swallow Tc-99mSc-H2O. The normal pattern shows sequential, aboral, discreet peaks with no retrograde movement over one min in three computer derived regions over the esophagus. Five of 16 B and 1 of 6 C demonstrated abnormal pattern. GER was assessed in the supine position by serially increasing extrinsic binder pressures from 0 to 100 Torr after ingestion of 300 ml of Tc-99mSc-orange juice (OJ). GER was present in 13 of 15 B and 0 of 11 C. Reflux ranged from 5.1% to 30% at 100 Torr. Hiatal hernia (HH) was identified in 14 of 16 B by endoscopy and in 10 of 16 by scintigraphy. GE was evaluated after a liquid meal of 300 ml Tc-99mSc-OJ and a solid meal of Tc-99mSc-egg salad sandwich. The supine subject was imaged anteriorly for 30 min (liquid) or 60 min (solid). GE was assessed an additional 10 min after MCP. Clearance time (50%) for solid Ge was calculated from extrapolated linear fits of decay corrected data. There was no significant difference in liquid or solid GE between B and C. The authors conclude the following: 1) ML detects B with lower sensitivity than previously reported; 2) EM disorders are frequently found in B; 3) GER is frequently identified in B; 4) HH can be identified by nuclear technique; and 5) B shows normal GE and responds to MCP.

  17. Usefulness of bone scintigraphic classification and quantitative evaluation of bone mineralization with X-CT and SPECT in renal osteodystrophy

    International Nuclear Information System (INIS)

    Okamura, Terue; Fukuda, Teruo; Inoue, Yuuichi; Koizumi, Yoshiko; Ikeda, Hozumi; Ochi, Hironobu

    1987-01-01

    1. Bone scintigraphy with Tc-99m-MDP was performed on 52 patients with chronic renal failure. These bone scintigrams were classified into 4 groups, each of which was correlated to laboratory data and quantitative data of bone mineralization. Group I (32 patients) showed high accumulation of Tc-99m-MDP in the bone. High level of Alk-Pase and c-PTH, low BMC/BW, low EMI number and high radionuclide activity ratio (RN ratio) were observed. Group II (9 patients) demonstrated nuclear bone images with high background activity. RN ratio was slightly higher than the normal. Group III (11 patients) showed extraosseous accumulation of Tc-99m-MDP in the lung, kidney or soft tissues. One patient belonged to Group I. High level of Ca x P product and slightly high RN ratio were observed. In both Group II and III, BMC/BW and EMI number were normal. Group IV (one patient) showed normal skeletal activity on bone scintigram. The mean duration of hemodialysis was the longest in Group I. Our scintigraphic classification is convenient and might contribute an understanding of patho-physiological bone changes in such patients. 2. Subtotal parathyroidectomy (S-PTX) was employed in 18 of 52 patients on chronic renal failure with secondary hyperparathyroidism. These patients were studied before and after S-PTX using 6 different procedures; conventional radiography, microdensitometry, bone mineral analysis, measurement of EMI number with X-CT (frontal bone), bone scintigraphy, and RN ratio (frontal bone/brain) with SPECT. On the bone scan, the diffuse increased activity in the calvarium became less prominent after S-PTX in all 18 patients. We devised a new method to quantify the bone changes revealed by the bone scan; the RN ratio with SPECT. The ratio decreased markedly after surgery. This method seems to be most useful for detecting dynamic bone changes sensitively and quantitatively. (author)

  18. Scintigraphic assessment of ectopic splenic tissue localization and function following splenectomy for trauma

    Energy Technology Data Exchange (ETDEWEB)

    Zwas, S.T.; Samra, D.; Samra, Y.; Sibber, G.R.

    1986-07-01

    Twenty-three subjects who had a splenectomy as a result of trauma underwent scintigraphic evaluation with a sensitive heat-denatured sup(99m)Tc-labeled red blood cells (DRBC). This method enabled detection of ectopic splenic tissue foci (ESTF) as small as 1x1 cm in diameter. ESTF splenosis or accessory spleen was detected in 15 cases (65%), a higher incidence than previously reported. The size of the ESTF ranged from 1x1 to 5x10 cm (0.8-40 cm/sup 2/), and 53% were less than 2x2 cma (3 cm/sup 2/). A new multiparametric scintigraphic evaluating technique is described, which estimates the quantity of ESTF and its grade of activity, relative to that of the liver. The technique is a highly efficient assessor of ESTF function. Good correlation was found between the size and activity of the ESTF and the presence of Howell-Jolly bodies (HJB), but with a low sensitivity for detecting small ESTF. Correlation was low between residual splenic tissue and concentrations of IgM, IgA and IgG immunoglobulins. The sup(99m)Tc-DRBC method described is recommended for verification of ESTF existence, localization, and function.

  19. Scintigraphic assessment of ectopic splenic tissue localization and function following splenectomy for trauma

    International Nuclear Information System (INIS)

    Zwas, S.T.

    1986-01-01

    Twenty-three subjects who had a splenectomy as a result of trauma underwent scintigraphic evaluation with a sensitive heat-denatured sup(99m)Tc-labeled red blood cells (DRBC). This method enabled detection of ectopic splenic tissue foci (ESTF) as small as 1x1 cm in diameter. ESTF splenosis or accessory spleen was detected in 15 cases (65%), a higher incidence than previously reported. The size of the ESTF ranged from 1x1 to 5x10 cm (0.8-40 cm 2 ), and 53% were less than 2x2 cma (3 cm 2 ). A new multiparametric scintigraphic evaluating technique is described, which estimates the quantity of ESTF and its grade of activity, relative to that of the liver. The technique is a highly efficient assessor of ESTF function. Good correlation was found between the size and activity of the ESTF and the presence of Howell-Jolly bodies (HJB), but with a low sensitivity for detecting small ESTF. Correlation was low between residual splenic tissue and concentrations of IgM, IgA and IgG immunoglobulins. The sup(99m)Tc-DRBC method described is recommended for verification of ESTF existence, localization, and function. (orig.)

  20. Scintigraphic method for evaluating reductions in local blood volumes in human extremities

    DEFF Research Database (Denmark)

    Blønd, L; Madsen, Jan Lysgård

    2000-01-01

    were carried out. No significant differences between results obtained by the use of one or two scintigraphic projections were found. The between-subject coefficient of variation was 14% in the lower limb experiment and 11% in the upper limb experiment. The within-subject coefficient of variation was 6......% in the lower limb experiment and 6% in the upper limb experiment. We found a significant relation (r = 0.42, p = 0.018) between the results obtained by the scintigraphic method and the plethysmographic method. In fractions, a mean reduction in blood volume of 0.49+0.14 (2 SD) was found after 1 min of elevation...... of the lower limb and a mean reduction of 0.45+/-0.10 (2 SD) after half a minute of elevation of the upper limb. We conclude that the method is precise and can be used in investigating physiologic and pathophysiologic mechanisms in relation to blood volumes of limbs not subject to research previously....

  1. Scintigraphic test of the vitality and functional fitness of organs conserved for transplantation

    International Nuclear Information System (INIS)

    Bozduganov, A.; Marinov, V.

    1976-01-01

    Having reviewed critically present-day methods of testing the vitality of isolated perfused organs, the authors propose their own. It is founded in the principles of colour scintigraphy after introduction of short-lived nuclides. The method was applied in testing 57 isolated preserved organs (5 kidneys, 12 livers, 5 hearts and 4 spleens from dogs; 2 kidneys and 27 livers from rabbits; 1 kidney and 1 liver from young pigs). Moreover, compararive scintigraphic and biochemical investigations were conducted on 2 dogs and 4 young pigs (A. Bozduganov, E. Simeonov, N. Bogdanova). The techniques of isolation and perfusion of the organ have been given a detailed description. Sup(113m)In was used as tracer. Areas of radioactivity deposits were visualized more or less intensely, depending on the degree of vitality and functional fitness still present actually; else, blanks were seen. Orthotransplantation and heterotransplantation with subsequent scintigraphic examination in vivo served, in scattered instances, the purpose of confirming or of rejecting ambiguous vitality findings in preserved organs. Advantages of the method are a general and specified evaluation of the organ in all of its areas; anatomical integrity of the object under test; applicability to various organs; possibility of conducting dynamic tests; accurate reproduction of vitality and functional findings, etc

  2. Dynamic renal scintigraphic estimation of deceased donor kidneys in a rat model

    Directory of Open Access Journals (Sweden)

    Huseyin Aydin Mitil

    2017-01-01

    Full Text Available At present a large number of the renal transplantations are being performed from the deceased donors. The success of these transplantations depends on the viability of the deceased donor kidneys. The aim of this study was to investigate the reliability of scintigraphic estimation of function of deceased donor kidneys by comparing the histopathologic and scintigraphic findings. Ten rats were included in the study (2–3 months old, 250–300 g, all male. Control scintigraphy was performed to all the rats by injection of 37 MBq Tc-99m DTPA from the tail vein in a dynamic manner. Brain death of the rats was achieved by inflation of a Fogartys catheter in the cranial cavity. Immediately, after brain death confirmation, dynamic renal scintigraphy was performed with the same parameters of control scintigraphy. In the comparison of scintigraphies obtained in the before and just after brain death period, there was impairment of tubular functions, concentration and excretion functions in the postbrain death period. In the immediate postbrain death period, there was a significant elevation in the glomerular filtration rate and time to maximum concentration values. In the histopathological evaluation of the kidney samples in the postbrain death period, there were definitive findings of tubular impairment. Dynamic renal scintigraphy also demonstrated definite impairment of tubular system and tubular functions in the deceased donor kidneys. This could explain the reason of the increased frequency of acute tubular necrosis seen among deceased donor kidneys.

  3. Assessment of skeleton scintigraphic study in breast cancer patients (relative to 322 observations)

    International Nuclear Information System (INIS)

    Liechtmaneger, Nicole.

    1976-01-01

    The results of scintigraphic whole-skeleton examinations have recently been improved by the use of sup(99m)Tc labelled phosphorus compounds. An assessment was made of 368 explorations, most of which were carried out with pyrophosphates and a few, the most recent, with ethane hydroxy diphosphonate, both labelled with sup(99m)Tc. For pyrophosphates a 10 mCi intraveinous injection is followed by a latency time of about 3 hours before the scintigraphic examination. In the case of diphosphonates, which have only been used lately and on relatively few cases, the same 10 mCi intravenous injection is administered but the latency time before the examination is only half as long, i.e. about 1h30 min, which is a definite advantage. However the number of examinations carried out with the latter is too small to afford a significant comparison between the two products. The main object of this work is to count the hyperfixation centres and to estimate their specificity and their coexistence or otherwise with clinical or radiological signs [fr

  4. Scintigraphic evaluation of primary congenital hypothyroidism: results of the Greek screening program

    Energy Technology Data Exchange (ETDEWEB)

    Panoutsopoulos, G.; Ilias, I.; Batsakis, C.; Christakopoulou, I. [Dept. of Nuclear Medicine, ' ' Sotiria' ' Hospital, Athens (Greece); Mengreli, C. [Inst. of Child Health, Athens (Greece)

    2001-04-01

    The Greek screening program for primary congenital hypothyroidism was initiated in 1979. By early 2000, thyrotropin measurements had been performed in 1,976,719 newborns, using dried blood spots obtained by heel prick. Among these children, 584 were diagnosed with congenital hypothyroidism (incidence: 1/3,384 births) and were given L-thyroxine (L-T{sub 4}) replacement therapy. In order to further evaluate and classify the children as having either an aplastic (AT) or an ectopic thyroid gland (ET) or as showing thyroidal dyshormonogenesis (DN, with a nomotopic gland), scintigraphic studies were performed at the age of 2-3 years. In 413 children of this age group (including 24 subsequently diagnosed as having had transient hypothyroidism, in whom L-T{sub 4} therapy was not resumed), thyroid hormones were measured and scintigraphic studies were done after withdrawal of L-T{sub 4} replacement treatment for 3 weeks. Given the long duration of the study, we used various scintigraphic modalities. In 96 children (group A), scintigraphy was performed using technetium-99m pertechnetate ({sup 99m}TcO{sub 4}{sup -}; 18.5 MBq given i.v.) and a rectilinear scanner. Seventy-three children (group B) were studied with {sup 99m}TcO{sub 4}{sup -} (18.5 MBq given i.v.) and a gamma camera equipped with a pinhole collimator. In these groups, atropine was administered 30 min prior to the study (0.02 mg/kg i.v. or i.m.) in order to reduce the secretion of saliva from the salivary glands. Finally, in the remaining 220 children (group C) iodine-123 sodium iodide ({sup 123}I-Na) (0.74-1.85 MBq i.v.) and the same gamma camera were used. Between-group comparisons of scintigraphic findings were done with the chi square test. In 191 children from group C, thyroglobulin (Tg) was measured and in 49 children ultrasound (US) was performed (categorising the gland as AT or ET/DN). Comparison of these modalities was done with the kappa statistic. In group A, 61.5% of children had AT, 26.0% had ET and

  5. Synergies between Last Planner System and OHSAS 18001 - A general overview = Sinergias entre el Last Planner System y la OHSAS 18001 - Una visión general

    Directory of Open Access Journals (Sweden)

    Xavier Brioso

    2017-08-01

    Full Text Available The present article’s main objective is to describe the synergies generated from the simultaneous application of the Last Planner System (LPS and OHSAS 18001. We explain the main principles, tools, techniques and practices of the Lean Construction philosophy and LPS that integrate and make synergy with the elaboration of Safety and Health Study, the implementation of the Safety and Health Plan, and with the OHSAS 18001. The LPS elements are correlated with the OHSAS 18001 requirements: (1 Policy; (2 Planning; (3 Implementation and Operation; (4 Checking; and (5 Management Review. The methodology used to validate the proposal is based in a review of the published literature in the last years, in which information was quoted from the Conferences of the International Group for Lean Construction (IGLC, Lean Construction Journal, Lean Construction Institute, among others. This paper hopes to bring integration and collaborative work from the Production and the Safety and Health Department. Resumen El presente artículo tiene como objetivo describir las sinergias generadas en la aplicación simultánea del Last Planner System (LPS y la OHSAS 18001. Se explican los principios, herramientas, técnicas y prácticas de la filosofía Lean Construction y del LPS que integran y generan sinergia con la elaboración del Estudio de Seguridad y Salud, con la implementación del Plan de Seguridad y Salud y con la OHSAS 18001. Se relacionan los elementos del LPS con los requisitos OHSAS 18001: (1 Política; (2 Planificación; (3 Implementación y operación; (4 Verificación; y (5 Revisión por la Dirección. La metodología empleada para validar la propuesta se basa en una revisión de la literatura publicada en los últimos años, en la que se citó información de la Conferencia del International Group for Lean Construction (IGLC, Lean Construction Journal, Lean Construction Institute, entre otros. Este trabajo pretende aportar en la integración y el trabajo

  6. Applying the HVRC VRdose Planner in the design of a Pneumatic Transfer System. Virtual, immersive and augmented reality - Feasibility study on the applications of the HVRC VRdose Planner

    International Nuclear Information System (INIS)

    Kapasi, Q.; Rhodes, C.

    2017-01-01

    The UK National Nuclear Laboratory (NNL) has developed simulations using the HVRC VRdose Planner, to assist in the design of a Pneumatic Transfer System (PTS) within an active facility. The PTS is at the concept stage, and rationale behind the installation is to facilitate the transfer of small radioactive packages more quickly and safely than is possible using current methods, which require significant input from operators and/or large and heavy equipment. VRdose Planner simulations have been used to determine the optimum pipe material and thickness in order to simulate the radiological effects of mal-operation. Simulations were undertaken to represent 3 point sources with a Spent Nuclear Fuel (SNF) inventory moving through the PTS from one end of the plant to another. Dose graphs have been used to understand the radiological implications of the sources and results found the risk to operators to be minimal. The visual animation of the simulation has provided the NNL with a quick and effective way of describing the scenario and identifying areas of risk which would otherwise have been time consuming. Applications: Design - The programme enables assessors from any discipline or background to interface with the virtual design, undertake operations and fully understand the environment proposed. Furthermore, where layouts are found wanting, they can be rectified in real time and fed back into the official design drawings and requirements. Safety Case - The development of a safety case are undertaken against a suite of 2D technical drawings which can be hard to follow, particularly for disciplines that do not have regular interface with design. Supplementing the safety case with the availability of advanced simulation and walk-through could prove a step change in efficiency and speed up understanding in this process. Decommissioning - The ability to map out radiation and simulate dose uptake is particularly beneficial during the decommissioning of existing facilities

  7. The value of scintigraphic examinations in the diagnosis of pathologic processes in the posterior scala in childhood and youth

    International Nuclear Information System (INIS)

    Piepgras, U.; Huber, G.; Emde, H.

    1980-01-01

    The diagnostical possibilities of computerized tomography (CT) and brain scintigraphy are compared. Serial scintigraphy by gamma cameras, scintigraphic examinations of the liquor space and the ventricles are discussed, too. In addition to CT, scintigraphy is also recommended in the following cases: hydrocephalus of unknown origin, dilatation of the IVth ventricle, diagnosis of recidive tumours, and unclear density differences. (L.E.)

  8. Epiphyseal involvement in Erdheim-Chester disease: radiographic and scintigraphic findings in a case with lytic lesions

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz-Hernandez, G.; Tajahuerce-Romera, G.M.; Latorre-Ibanez, M.D.; Lara-Pomares, A. [Servicio de Medicina Nuclear, Hospital Provincial de Castellon (Spain); Vila-Fayos, V. [Servicio de Reumatologia, Hospital Comarcal de Vinaroz (Spain)

    2000-08-01

    We reported a symmetric increase of activity in lower links secondary to Erdheim-Chester disease and demonstrated by bone scans and radiographs. An inusual scintigraphic and radiographic appearance with epiphyseal involvement and lytic lesions is described. Differential diagnosis of bone scan and radiographic findings is discussed. (orig.)

  9. Influence of the choice of parameters of the TAC in the calculation of volumes for different planners

    International Nuclear Information System (INIS)

    Sanchez Mazon, J.; Raba Diez, J. L.; Vazquez Rodriguez, J. A.; Pacheco Baldor, M. T.; Mendiguren Santiago, M. A.

    2011-01-01

    In the Protocol for the control treatment planning systems with ionizing radiation of the proposed SEFM tests to verify proper operation of the calculation in the evaluation of DVH (Dose Volume Histogram). The calculation of the volume that makes a planner may have important implications because it can trigger an overestimation of the dose or otherwise. We present a comparison of the calculation of volumes estimated with 4 different planners.

  10. On designing geometric motion planners to solve regulating and trajectory tracking problems for robotic locomotion systems

    International Nuclear Information System (INIS)

    Asnafi, Alireza; Mahzoon, Mojtaba

    2011-01-01

    Based on a geometric fiber bundle structure, a generalized method to solve both regulation and trajectory tracking problems for locomotion systems is presented. The method is especially applied to two case studies of robotic locomotion systems; a three link articulated fish-like robot as a prototype of locomotion systems with symmetry, and the snakeboard as a prototype of mixed locomotion systems. Our results show that although these motion planners have an open loop structure, due to their generalities, they can steer case studies with negligible errors for almost any complicated path.

  11. On designing geometric motion planners to solve regulating and trajectory tracking problems for robotic locomotion systems

    Energy Technology Data Exchange (ETDEWEB)

    Asnafi, Alireza [Hydro-Aeronautical Research Center, Shiraz University, Shiraz, 71348-13668 (Iran, Islamic Republic of); Mahzoon, Mojtaba [Department of Mechanical Engineering, School of Engineering, Shiraz University, Shiraz, 71348-13668 (Iran, Islamic Republic of)

    2011-09-15

    Based on a geometric fiber bundle structure, a generalized method to solve both regulation and trajectory tracking problems for locomotion systems is presented. The method is especially applied to two case studies of robotic locomotion systems; a three link articulated fish-like robot as a prototype of locomotion systems with symmetry, and the snakeboard as a prototype of mixed locomotion systems. Our results show that although these motion planners have an open loop structure, due to their generalities, they can steer case studies with negligible errors for almost any complicated path.

  12. Early phase clean-up actions after nuclear accidents. Guidelines for the planner. Final report

    International Nuclear Information System (INIS)

    Ulvsand, T.

    1997-06-01

    The work reported has been performed with the purpose of working out a guide for planners of early clean-up actions in nuclear fallout situations and for decision makers in the Nordic countries. The actions considered are hosing of roofs, walls and paved areas, lawn mowing, removal of snow, pruning of trees and bushes and vacuum cleaning of streets. The expected effects, mainly as life time dose reduction, and consequences regarding practicability, waste produced, staffing and protection are presented for urban, suburban and rural living environments. The work has been performed within the fram work of the Nordic Nuclear Safety Research Program 1994-97 (Statens Raeddningsverk). (au)

  13. Development of a Healthy Urban Route Planner for cyclists and pedestrians in Amsterdam

    Science.gov (United States)

    van der Molen, Michiel; Ligtenberg, Arend; Vreugdenhil, Corne; Steeneveld, Gert-Jan

    2017-04-01

    Cities are hotspots of air pollution and heat stress, the exposure to which results in nuisance, health risks, cost of medication, reduced labour productivity and sick leave for citizens. Yet the air pollution and heat stress are spatially and temporally unevenly distributed over the city, depending on pollutant emissions, street design and atmospheric turbulent mixing and radiation. This spatiotemporal variation allows pedestrians and bikers to choose alternative routes to minimize their exposure, if the distribution is known. In this project, we develop a route planner for bicyclists and pedestrians for Amsterdam (NL), that proposes routes and departure times based on model simulations of weather and air quality. We use the WRF-Chem atmosphere and air quality model at unprecedented grid spacing of 100-m (Ronda et al, 2015, Super et al, 2016), with an underlying urban canopy model and NOx and PM10 emissions. The emissions by traffic are calculated based on observed traffic intensities and emission factors. An urban land use map will characterize urban density and street configuration to estimate urban heat storage (Attema et al, 2015). WRF-Chem runs will be issued daily for a lead time of 48 hours, resulting in forecast maps of temperature and pollutant concentrations that will be uniquely expressed in a metric that combines both threats. The hourly fields of this metric are provided to the route planner based on the open source routing library pgRouting to identify the more healthy routes on the route network of Amsterdam. The objectives of the healthy urban route planner are to raise awareness of heat and air quality issues in Amsterdam, to provide an innovative adaptation tool for citizens and tourists, to locate the most important bottlenecks in (the exposure to) air pollution and heat stress, and ultimately to test the readiness of the travellers to use the information and adapt the route. We expect to particularly target a group of lung- and cardiovascular

  14. Scintigraphic evaluation of the osteoblastic activity of rabbit tibial defects after HYAFF11 membrane application.

    Science.gov (United States)

    Mermerkaya, Musa Uğur; Doral, Mahmut Nedim; Karaaslan, Fatih; Huri, Gazi; Karacavuş, Seyhan; Kaymaz, Burak; Alkan, Erkan

    2016-05-03

    An unfavorable condition for bone healing is the presence of bone defects. Under such conditions, a material can play a role to cover fractured or defective bone. Technological advances now allow for the use of such material. Hyalonect(®) (Fidia Advanced Biopolymers SLR, Italy), a novel membrane comprising knitted fibers of esterified hyaluronan (HYAFF11) can be used to cover fractured or grafted bone and can also serve as a scaffold to keep osteoprogenitor cells in place. The aim of this study was to compare osteoblastic activity by the use of scintigraphic methods in defective rabbit tibias during early-phase bone healing with or without a hyaluronan-based mesh. Two groups (A and B) of New Zealand albino rabbits were used; each group included 10 animals. Operations on all rabbits were performed under general anesthesia. We also resected 10-mm bone segments from each animal's tibial diaphysis. After resection, tibias with defects were fixed using Kirschner wires. In group A, no hyaluronan-based mesh was used. In group B, tibial segmental defects were enclosed with a hyaluronan-based mesh. The rabbits were followed up for 4 weeks postoperatively, after which bone scintigraphic studies were performed on each animal to detect and compare osteoblastic activity. The mean count in the fracture side of the hyaluronan-based mesh group was significantly higher compared to that of the group A (p = 0.019). However, there was no significant difference between group B and control rabbits with respect to the mean count on the intact bone side (p = 0.437). The bone defect (fracture)/intact bone mean count ratio was significantly higher in group B compared to group A (p = 0.008). A hyaluronan-based mesh plays a role in promoting osteoblastic activity. Hyalonect(®) is suitable for restoring tissue continuity whenever the periosteal membrane is structurally impaired or inadequate. Our results demonstrated that, during early-phase bone healing, osteoblastic activity

  15. Scintigraphic imaging of oncogenes with antisense probes: does it make sense?

    International Nuclear Information System (INIS)

    Urbain, J.L.C.; Shore, S.K.; Vekemans, M.C.; Cosenza, S.C.; DeRiel, K.; Patel, G.V.; Charkes, N.D.; Malmud, L.S.; Reddy, E.P.

    1995-01-01

    The aim of this study was to demonstrate that cells which are expressing a particular mRNA transcript do preferentially and specifically retain the antisense probe targeting that mRNA. Using a mouse plasmacytoma cell line (MOPC315) which produces high levels of IgA heavy chain mRNA, a control mouse pre B cell line (7OZ/3B), a human mammary cell line (MCF7) which expresses the erbB2 or neu oncogene, MOPC315 cells as neu-negative controls, and antisense DNA oligonucleotides complementary to the 5' region of the mRNAs and the sense sequence, we have shown that there is a preferential, specific retention of the IgA and neu antisense sequence in MOPC315 and MCF7 cells, respectively. We have further demonstrated that this retention is time and concentration dependent with a maximum at 24 h. We conclude that cancer cells which express a particular oncogene are suitable targets for radiolabeled antisense deoxyoligonucleotides directed toward the oncogene transcript. (orig.)

  16. Collaborative planning for city development. A perspective from a city planner

    Directory of Open Access Journals (Sweden)

    Kamalia Purbani

    2017-04-01

    Full Text Available A number of definitions related to collaborative governance have been developed since early 2000. The common characteristics of collaborative governance are, among others, policy consensus, community visioning, consensus rule-making, and collaborative network structures. Collaborative planning is a new paradigm of planning for a complex contemporary society through which it encourages people to be engaged in a dialogue in a situation of equal empowerment and shared information to learn new ideas through mutual understanding, to create innovative outcomes and to build institutional capacity. This indicates that collaborative planning can provide policy makers with more effective community participation. Collaborative process is the key of collaborative planning which also emphasizes the significant role of collaborative leadership. The process includes a participatory activity of dialogue oriented to the joint decision and summarized in a collaborative process. The collaborative leadership is crucial for setting and maintaining clear ground rules, building trust, facilitating dialogue, and exploring mutual gains. Along with the shift of planning paradigm, the role of city planner will also change since the city planning deals with the political process. In the political process, city planners must be able to perform as technocrats, bureaucrats, lawyers and politicians who always uphold their ethics because they are responsible to the society, the assignor for their integrity and professionalism.

  17. The Creative Side of the Reflective Planner. Updating the Schön’s Findings

    Directory of Open Access Journals (Sweden)

    Maria Rosaria Stufano Melone

    2014-05-01

    Full Text Available The self-reflection on their own work has always been present in all designers, including architects and planners. In the mid 80-90 Donald Schön has made more explicit this aspect, which until then had not found a systematic scientific treatment.  The results of Schön are the basis of practical planning of the 90s period. However, the Schön's analysis reveals a context of knowledge of mental functioning typical of the conceiving period. From the 90s until now numerous advances in knowledge of the mechanisms of rationality, reflection and creativity have been made, and in this context we are interested in the progress made in the field of creativity.  We try to integrate and update the Schön's reflection with the new available theories such as the CK theory to offer planners a more innovated range of tools in order to understand and make better use of their creativity and self-reflection about their own creativity.

  18. Drivers’ Visual Behavior-Guided RRT Motion Planner for Autonomous On-Road Driving

    Directory of Open Access Journals (Sweden)

    Mingbo Du

    2016-01-01

    Full Text Available This paper describes a real-time motion planner based on the drivers’ visual behavior-guided rapidly exploring random tree (RRT approach, which is applicable to on-road driving of autonomous vehicles. The primary novelty is in the use of the guidance of drivers’ visual search behavior in the framework of RRT motion planner. RRT is an incremental sampling-based method that is widely used to solve the robotic motion planning problems. However, RRT is often unreliable in a number of practical applications such as autonomous vehicles used for on-road driving because of the unnatural trajectory, useless sampling, and slow exploration. To address these problems, we present an interesting RRT algorithm that introduces an effective guided sampling strategy based on the drivers’ visual search behavior on road and a continuous-curvature smooth method based on B-spline. The proposed algorithm is implemented on a real autonomous vehicle and verified against several different traffic scenarios. A large number of the experimental results demonstrate that our algorithm is feasible and efficient for on-road autonomous driving. Furthermore, the comparative test and statistical analyses illustrate that its excellent performance is superior to other previous algorithms.

  19. Drivers' Visual Behavior-Guided RRT Motion Planner for Autonomous On-Road Driving.

    Science.gov (United States)

    Du, Mingbo; Mei, Tao; Liang, Huawei; Chen, Jiajia; Huang, Rulin; Zhao, Pan

    2016-01-15

    This paper describes a real-time motion planner based on the drivers' visual behavior-guided rapidly exploring random tree (RRT) approach, which is applicable to on-road driving of autonomous vehicles. The primary novelty is in the use of the guidance of drivers' visual search behavior in the framework of RRT motion planner. RRT is an incremental sampling-based method that is widely used to solve the robotic motion planning problems. However, RRT is often unreliable in a number of practical applications such as autonomous vehicles used for on-road driving because of the unnatural trajectory, useless sampling, and slow exploration. To address these problems, we present an interesting RRT algorithm that introduces an effective guided sampling strategy based on the drivers' visual search behavior on road and a continuous-curvature smooth method based on B-spline. The proposed algorithm is implemented on a real autonomous vehicle and verified against several different traffic scenarios. A large number of the experimental results demonstrate that our algorithm is feasible and efficient for on-road autonomous driving. Furthermore, the comparative test and statistical analyses illustrate that its excellent performance is superior to other previous algorithms.

  20. Drivers’ Visual Behavior-Guided RRT Motion Planner for Autonomous On-Road Driving

    Science.gov (United States)

    Du, Mingbo; Mei, Tao; Liang, Huawei; Chen, Jiajia; Huang, Rulin; Zhao, Pan

    2016-01-01

    This paper describes a real-time motion planner based on the drivers’ visual behavior-guided rapidly exploring random tree (RRT) approach, which is applicable to on-road driving of autonomous vehicles. The primary novelty is in the use of the guidance of drivers’ visual search behavior in the framework of RRT motion planner. RRT is an incremental sampling-based method that is widely used to solve the robotic motion planning problems. However, RRT is often unreliable in a number of practical applications such as autonomous vehicles used for on-road driving because of the unnatural trajectory, useless sampling, and slow exploration. To address these problems, we present an interesting RRT algorithm that introduces an effective guided sampling strategy based on the drivers’ visual search behavior on road and a continuous-curvature smooth method based on B-spline. The proposed algorithm is implemented on a real autonomous vehicle and verified against several different traffic scenarios. A large number of the experimental results demonstrate that our algorithm is feasible and efficient for on-road autonomous driving. Furthermore, the comparative test and statistical analyses illustrate that its excellent performance is superior to other previous algorithms. PMID:26784203

  1. Urban Land Allocation Model of Territorial Expansion by Urban Planners and Housing Developers

    Directory of Open Access Journals (Sweden)

    Carolina Cantergiani

    2017-12-01

    Full Text Available Agent-based models have recently been proposed as potential tools to support urban planning due to their capacity to simulate complex behaviors. The complexity of the urban development process arises from strong interactions between various components driven by different agents. AMEBA (agent-based model for the evolution of urban areas is a prototype of an exploratory, spatial, agent-based model that considers the main agents involved in the urban development process (urban planners, developers, and the population. The prototype consists of three submodels (one for each agent that have been developed independently and present the same structure. However, the first two are based on a land use allocation technique, and the last one, as well as their integration, on an agent-based model approach. This paper describes the conceptualization and performance of the submodels that represent urban planners and developers, who are the agents responsible for officially launching expansion and defining the spatial allocation of urban land. The prototype was tested in the Corredor del Henares (an urban–industrial area in the Region of Madrid, Spain, but is sufficiently flexible to be adapted to other study areas and generate different future urban growth contexts. The results demonstrate that this combination of agents can be used to explore various policy-relevant research questions, including urban system interactions in adverse political and socioeconomic scenarios.

  2. Evaluation of myocardial involvement in Duchenne's progressive muscular dystrophy with thallium-201 myocardial perfusion imaging

    International Nuclear Information System (INIS)

    Kawai, Naoki; Sotobata, Iwao; Okada, Mitsuhiro

    1985-01-01

    Myocardial involvement in progressive muscular dystrophy of the Duchenne type was evaluated in 19 patients using thallium-201 myocardial perfusion imaging. A qualitative analysis was performed from five projection images by three experienced physicians. Distinct perfusion defects were shown in 13 patients, especially in the LV posterolateral or posterior wall (11 patients). There was no significant relationship between the presence of perfusion defects and the skeletal muscle involvements or thoracic deformities assessed by transmission computed tomography. Extensive perfusion defects were shown in 2 patients who died of congestive heart failure 1 to 2 years after the scintigraphic study. Progression of the myocardial scintigraphic abnormalities were considered to be minimal in 7 of 9 patients who underwent two serial scintigraphic studies over 2 to 3 years. It was concluded that thallium myocardial perfusion imaging is a useful clinical technique to assess myocardial involvement in Duchenne's progressive muscular dystrophy. (author)

  3. Diagnostic accuracy of scintigraphic methods in the differential diagnosis of focal liver lesions

    International Nuclear Information System (INIS)

    Czermak, H.; Gomez, I.; Gallowitsch, H.J.; Lind, P.

    1993-01-01

    In a retrospective study of 160 patients who were examined within 12 months, we analysed the diagnosic value of scintigraphic techniques in the differential diagnosis of solid focal liver lesions. Haemangiomas were found in 77 patients. Bloodpool scintigraphy was true-positive in 66 (sensivitity 85%); for lesions greater than 2 cm in diameter, sensitivity increased to 94%. Metastases of CEA-expressing tumors were found in 42 patients, anti-CEA-immunoscintigraphy was true-positive in 33 patients (sensitivity 78.5%). Focal nodulary hyperplasia was found in 3 patients, adenomas in 6 patients. In the remaining 32 patiens we saw 4 hepatocellular carcinomas, 28 metastases from lung and breast cancer, 2 echinococcus cysts and 1 choledochus cyst. (orig.) [de

  4. Scintigraphic localization of pheochromocytomas using 131 I-meta-iodobenzylguanidine. Comparison with computerized tomography

    International Nuclear Information System (INIS)

    Charbonnel, B.; Coornaert, S.; Tellier, J.L.; Peltier, P.; Chatal, J.F.

    1984-01-01

    Meta-iodobenzylguanidine was synthesized, radiolabelled with I 131 or I 123 and injected to 28 controls and 7 patients totalizing 13 foci of pheochromocytoma. The tumour was located in one adrenal gland in 3 cases, in both adrenal glands in 1 case, and between the aorta and the vena cava in 1 case; 2 were malignant with metastases. Scintigraphy was negative in all controls, whereas all pheochromocytomas were clearly demonstrated 24 h after injection, except one regarded as non functional due to necrosis. By comparison, CT readily showed the tumour in 7 cases, showed it only thanks to scintigraphic guidance in 4 cases and failed in 2 cases. It is concluded that scintigraphy with meta-iodo-benzylguanidine provides a safe and reliable means of locating a wide range of pheochromocytomas [fr

  5. Scintigraphic disagreement in the study of thyroid nodules using technetium 99m and iodine 131

    International Nuclear Information System (INIS)

    Planchon, C.A.

    1977-01-01

    116 patients with thyroid nodules, iso or hyperfixing, heterogeneous or scintigraphically indistinct after administration of pertechnetate 99mTc, were systematically re-examined with iodine 131. The results of this study are as follows: 1) 99mTc, while its advantages justify its extensive application, is an imperfect tracer and cannot replace iodine 131 altogether. In fact in 12% of the cases the results were conflicting. 2) The technological conditions may sometimes be to blame but the hypothesis of a special metabolic behavior of the nodule examined seems plausible in certain cases of disagreement (blocking of hormone synthesis and escape of non-hormonal iodine). 3) These observations correspond to no particular anatomo-clinical factors. The legitimate conclusion therefore is that the exclusive use of 99mTc could result in failure to recognise a non-functional nodule (1 case in about 10), a possibility not to be neglected because of the risk of cancer [fr

  6. Scintigraphic and Endoscopic Evaluation of Radiation-induced Acute Gastrointestinal Syndrome in Micro-pig Model

    International Nuclear Information System (INIS)

    Lee, Seung-Sook; Kim, Kyung-Min; Kim, Jin; Jang, Won-Suk; Lee, Jung-Eun; Kim, Noo-Ri; Lee, Sun-Joo; Kim, Mi-Sook; Ji, Young-Hoon; Cheon, Gi-Jeong; Lim, Sang-Moo

    2007-01-01

    Micro-pig model can be served as a proper substitute for humans in studying acute radiation syndrome following radiation-exposure accidents, especially showing similar clinico-pathologic response of hematopoietic and gastrointestinal (GI) syndrome to human. Among acute GI syndrome induced by radiation, GI motility disturbance has not been studied, however, it would be important in a viewpoint of affecting infectious progression from GI tract. Here, we employed scintigraphy of GI transit time and sequential endoscopic examination and tissue sampling in micropigs followed by abdominal radiation exposure. The specific aims of this study are to evaluate objective evidence of GI motility disturbance by scintigraphic evaluation and to find corresponding clinicoapthologic changes in radiation-induced acute GI syndrome

  7. Scintigraphic control of bone-fracture healing under ultrasonic stimulation: An animal experimental study

    International Nuclear Information System (INIS)

    Klug, W.; Franke, W.G.; Knoch, H.G.

    1986-01-01

    In a model of closed lower-leg fracture in rabbits and of secondary bone-fracture healing, scintigraphic control until biological healing was performed. Biological fracture healing was assumed for a region of interest (ROI)-activity ratio close to 1.0. After application of sup(99m)Tc-HEDP, 151 examinations were performed. ROI activity increased significantly until day 14 p.i. and reached the maximum value (Q=6.44) on day 14 postfracture. Sixty-one lower leg fractures were treated by ultrasound from days 14-28 postfractures. These stimulated fractures were biologically healed on day 168 postfracture. The fractures that were not treated by ultrasound could not be detected by scanning after day 203 postfracture. (orig.)

  8. Scintigraphic demonstration of single- or two-phase gastric emptying in diabetics

    International Nuclear Information System (INIS)

    Eikman, E.A.; Leichter, S.; Waldholtz, B.; Tenorio, L.; Brady, P.

    1989-01-01

    This paper discusses how a modified scintigraphic test of gastric emptying revealed two types of abnormal gastric emptying in diabetic patients. After ingestion of 100 mL of cooked egg whites labeled with 0.5 mCi of Tc-99m sulfur colloid, the geometric mean stomach radioactivity was recorded serially for 90 minutes. Linear regression computed for the log of radioactivity versus time facilitated recognition of changes in gastric emptying. In 16 of 25 consecutive diabetic patients with postprandial symptoms, initial slow emptying (half-life,>100 minutes) was observed. Single-phase emptying was shown in seven of these patients. In nine patients, the slow-emptying phase lasted up to 50 minutes, followed by a distinct second phase of normal or rapid emptying (half-life, <40 minutes). The existence of different gastric emptying implies differing mechanisms of delay and may be important in treatment

  9. Coincidence of scintigraphic false positive and false negative findings in parathyroid and thyroid adenomas (case report)

    Energy Technology Data Exchange (ETDEWEB)

    Mana, O.; Zatta, G.; Boccolari, S.; Barbesti, S.; Tarolo, G.L.

    1987-04-01

    The subtractive double tracer scintigraphy with /sup 201/Tl and /sup 99m/Tc is a useful technique in studying parathyroid nodules; nevertheless, this method can give misleading informations especially in presence of thyroid nodules with false positive and false negative findings. In this case report the technique was applied in studying a patient with three nodules (two thyroid adenomas and one parathyroid adenoma), where both scintigraphic and echographic methods provided misleading informations. The selective uptake of /sup 201/Tl in the upper region of the right thyroid lobe gave a false positive finding, while the increased uptake of /sup 99m/Tc in a hyperfunctioning thyroid adenoma of left lobe masked the parathyroid adenoma laying below, giving a false negative finding.

  10. Comparison of Scintigraphic and Radiological Results in the Diagnosis of Pancreatic Diseases

    Energy Technology Data Exchange (ETDEWEB)

    Deininger, H. K.; Sielaff, H. J. [Strahlenklinik der Staedt. Krankenanstalten Heilbronn, Heilbronn, Federal Republic of Germany (Germany)

    1969-05-15

    The results obtained by pancreas scanning and standard radiological diagnostic methods are compared. The roentgenographic examinations of the stomach, intestine, colon, biliary tract and kidneys were performed by standard X-ray methods and by abdominal tomography with pneumoretroperitoneum. Special methods of a radiological pancreatic diagnosis, e.g. selective angiography and intra-operative pancreatography, are intentionally not considered. So far 192 pancreas scans have been carried out after administration of {sup 75}Se-1 -selenomethionine. The patients were prepared either with a special diet or a fasting period. The quality of the pancreas scans depended on the functional state of the pancreatic tissue and a comparison with phantom studies allowed an approximate estimation of the extent of the parenchymatous lesions. Of the 87 cases with proven pancreatic diseases the results were compared with the scintigraphical and radiological findings. This comparative research illustrates the superiority of pancreas scanning over the conventional rontgenographic methods in the exclusion or detection of pancreatic diseases. (author)

  11. Scintigraphic changes of osteoarthritis: An analysis of findings during routine bone scans to evaluate the incidence in an Indian population

    International Nuclear Information System (INIS)

    Samuel, Aban M; Jain, HM

    2012-01-01

    The reported prevalence of osteoarthritis (OA) varies according to the method that is used to detect it. X-rays are commonly used in the diagnosis of OA. However, marked osteoarthritic damage must be present to detect characteristic changes with radiologic imaging. Our intention was to evaluate bone scans (1) he occurrence of such changes, (2) he incidence of OA (single or multiple joints) in the general population (a mixture of urban and rural) who were asymptomatic. Data on OA incidence in India is sketchy and sparse as against more detailed information obtained from USA and European nations. Also, clinical rheumatologists are not well-versed with the potential application of bone scans in the management of arthritides. Two hundred and eighty nine planar images of routine bone scans were randomly evaluated by two trained nuclear medicine physicians. The ages of the patients ranged from 20 to over 80 years. It is observed that as the age increases, the incidence of joint involvement increases. However, it is worth noting that even in the age group of 20-40 years, as many as 34% of asymptomatic persons have involvement of the joints. In this age group, as the manifestation is probably in the inception stage, there is a tendency for single joint involvement as against multiple joints seen in the older age groups. Another point to note is that the incidence of joint involvement was not affected by weight. In our patient population, gross obesity was not seen. The predominant joints involved are the knees and hips, followed by the shoulders and ankles. Females show a higher incidence than males. Some patients would be having only a single site or multiple site involvement. This observation is important as in a single, simple test whole body survey gives more information with low radiation burden. Scintigraphic prevalence of OA is higher than reported in US, Europe, and Asia as this test is more sensitive in detecting early changes as compared to radiological changes

  12. What do District Health Planners in Tanzania think about improving priority setting using 'Accountability for Reasonableness'?

    Directory of Open Access Journals (Sweden)

    Olsen Oystein

    2007-11-01

    Full Text Available Abstract Background Priority setting in every health system is complex and difficult. In less wealthy countries the dominant approach to priority setting has been Burden of Disease (BOD and cost-effectiveness analysis (CEA, which is helpful, but insufficient because it focuses on a narrow range of values – need and efficiency – and not the full range of relevant values, including legitimacy and fairness. 'Accountability for reasonableness' is a conceptual framework for legitimate and fair priority setting and is empirically based and ethically justified. It connects priority setting to broader, more fundamental, democratic deliberative processes that have an impact on social justice and equity. Can 'accountability for reasonableness' be helpful for improving priority setting in less wealthy countries? Methods In 2005, Tanzanian scholars from the Primary Health Care Institute (PHCI conducted 6 capacity building workshops with senior health staff, district planners and managers, and representatives of the Tanzanian Ministry of Health to discussion improving priority setting in Tanzania using 'accountability for reasonableness'. The purpose of this paper is to describe this initiative and the participants' views about the approach. Results The approach to improving priority setting using 'accountability for reasonableness' was viewed by district decision makers with enthusiastic favour because it was the first framework that directly addressed their priority setting concerns. High level Ministry of Health participants were also very supportive of the approach. Conclusion Both Tanzanian district and governmental health planners viewed the 'accountability for reasonableness' approach with enthusiastic favour because it was the first framework that directly addressed their concerns.

  13. Stress fractures of the humerus, radius, and tibia in horses: clinical features and radiographic and/or scintigraphic appearance

    International Nuclear Information System (INIS)

    Mackey, V.S.; Trout, D.R.; Meagher, D.M.; Hornof, W.J.

    1987-01-01

    The medical records, radiographic and nuclear scintigraphic findings of 26 racing horses with 27 stress fracture episodes of the humerus, radius, or tibia were reviewed. The purposes of this study were to describe the radiographic and/or scintigraphic features of stress fractures of the humerus, radius, or tibia, and to evaluate the signalment and history of horses in which stress fracture occurred. Stress fractures of the three long bones examined were primarily seen in 2- and 3-year-old male Thoroughbred horses; commonly, the onset of lameness was immediately following training gallops or racing. There were 13 humeral stress fracture episodes in 12 horses. Ten were in the proximal caudolateral cortex, and three were in the distal craniomedial cortex. Radical stress fractures were seen in three horses, all in the midshaft radius. Tibial stress fractures were diagnosed in 11 horses. They were located in the proximal lateral tibia in six horses, the distal caudolateral tibia in three horses, and the midshaft tibia in three horses. Fifteen stress fractures were diagnosed with radiography alone, one was diagnosed with scintigraphy alone, nine were diagnosed with radiographs and scintigraphy, and, in two horses, radiographs were negative, but the scintigraphic findings were consistent with stress fracture

  14. Correlation between radiological, scintigraphic and histological changes in bone in rabbits following irradiation with single and fractionated doses

    International Nuclear Information System (INIS)

    Burgener, F.A.; King, M.A.; Weber, D.A.

    1979-01-01

    In the left hind legs of eight rabbits were irradiated with 1,750 rad in a single dose or with 4,650 rad divided over a period of three weeks. These animals, as well as four who had not been irradiated, were examined periodically radiologically and with 99 mTechnetium pyrophosphate scintigrams during one year. No difference could be detected between the results of the single and fractionated doses. Scintigraphically there was a biphasic increase in uptake, the first peak co-inciding with the irradiation and of vascular origin, whereas the second peak occured at four months and was due to a change in bone metabolism. At the end of a year uptake in the irradiated limb was slightly reduced. The earliest radiological changes were found after six months, at the end of the second scintigraphic peak; they consisted of coarsening and blurring of the trabeculae, non-homogeneous spotty mineralisation and endosteal scalloping. Six animals developed a radiation-induced bone sarcoma, first demonstrated either by scintigraphy or radiology depending on its histology. The value of combining radiological and scintigraphic examinations for the early detection of post-radiation abnormalities is stressed. (orig.) [de

  15. Writing a Brochure Is as Easy as 1-2-3. A Kit for Workshop and Program Planners.

    Science.gov (United States)

    Witt, Ted

    This kit is intended to help program planners write the information needed for an effective brochure advertising a workshop, seminar, conference, class, or academy. The kit contains the following sections: (1) Benefit Headlines Capture Reader Attention; (2) Establish a Need Quickly; (3) Identifying the Audience; (4) Making Top Names Tops; (5)…

  16. Blending the Roles of Interpreter, Entrepreneur, Collaborator. A New Model for Conferences and Institutes Program Planners. The Guide Series.

    Science.gov (United States)

    Dahl, Carolyn Carson

    This six-chapter guide suggests a new approach to describing the knowledge, competencies, and managerial roles inherent in planning effective conferences and institutes. Chapter 1 introduces the many roles of the conferences and institutes program planner and discusses program formats and what makes conference programs unique learning events.…

  17. A proposal to study the esophageal transit by biomagnetic and scintigraphic study

    International Nuclear Information System (INIS)

    Daghastanli, N.A.; Braga, F.J.H.N.; Baffa, O.

    1996-01-01

    The initial results for a new apparatus to study the esophageal transit time is studied in asymptomatic persons for a yogurt bolus (10 ml). The bolus is uniformly labeled with 5 g of ferrite powder (biomagnetic study, B) or 350 MBq of 99m Tc (scintigraphic study, C). For the B study the detection is made by means two pair of coils in opposite phase excited by a 10 k Hz sinusoidal voltage. The signal response is obtained when the bolus traverses the coils placed on the regions-of-interest (ROIs) of the esophagus (furcula, F and xiphoid process, X) and produces a signal voltage that is measured by a lock-in amplifier Stanford SR530. For C studies an Orbiter Siemens scintillation camera is used linked to a computer. The data analysis shows a (4.1±0.7)s in B studies and (3.7±0.9)s in C studies (R=0.6, P<0.07)

  18. Sacroiliitis detected by bone scintiscanning: a clinical, radiological, and scintigraphic follow-up study

    International Nuclear Information System (INIS)

    Chalmers, I.M.; Lentle, B.C.; Percy, J.S.; Russell, A.S.

    1979-01-01

    Twenty-four patients had abnormal sacroiliac joints detected by quantitative sacroiliac scintigraphy but no radiological evidence of sacroiliitis on original investigation. They were studied again after intervals of 12 to 36 months. Four patients developed radiological change. Two young, HLA B27-positive men had undoubted ankylosing spondylitis, and a young woman had possible ankylosing spondylitis. A middle-aged man had changes that could be attributed to post-traumatic osteoarthrosis. Of the remaining 20 cases, 15 had symptoms and signs suggestive of inflammatory disease of the axial skeleton (and peripheral arthropathy in 5 cases). The sexes were affected equally (8 females, 7 Males), and only 2 of the 15 were B27-positive. The response to anti-inflammatory medication was generally good to excellent, and scintiscans tended to improve. Of the remaining 5 patients, 3 had mechanical or traumatic problems, and in 2 there was no explanation for the abnormal sacroiliac scintiscan. It is concluded that quantitative sacroiliac scintigraphy may detect ankylosing spondylitis prior to the development of radiological change and that it can identify an organic basis for backache in patients with a spondylitis-like syndrome. The clinical circumstances must be taken into account, as scintigraphic abnormalities are not diagnostic of any specific disease entity. (author)

  19. Detection and localization of lower gastrointestinal bleeding site with scintigraphic techniques

    International Nuclear Information System (INIS)

    Alavi, A.

    1988-01-01

    Successful management of acute gastrointestinal (GI) bleeding frequently depends on accurate localization of the bleeding site. History and clinical findings are often misleading in localizing the site of hemorrhage. The widespread application of flexible endoscopy and selective arteriography now provides accurate diagnoses for the majority of patients with upper GI tract hemorrhage, but lower GI bleeding still is a serious diagnostic problem. Endoscopy and barium studies are of limited value in examining the small bowel and colon in the face of active hemorrhage. Arteriography, although successful in many cases, has limitations. The angiographic demonstration of bleeding is possible only when the injection of contrast material coincides with active bleeding. Since lower GI bleeding is commonly intermittent rather than continuous, a high rate of negative angiographic examinations has been reported. Repeated angiography to pursue recurrent episodes of bleeding is impractical. Because of these shortcomings, in the past decade several noninvasive scintigraphic techniques have been developed to detect and localize sites of GI bleeding. In this chapter the authors discuss details related to the technetium 99m sulfur colloid (Tc-SC) and technetium 99m-labeled red blood cell (Tc-RBC) techniques

  20. Scintigraphic examinations after stent implantation in central airways; Szintigraphische Untersuchungen bei Stents in den zentralen Atemwegen

    Energy Technology Data Exchange (ETDEWEB)

    Richter, W.S.; Kettner, B.I.; Munz, D.L. [Klinik und Poliklinik fuer Nuklearmedizin, Universitaetsklinikum Charite, Medizinische Fakulteat der Humboldt-Univ. zu Berlin (Germany)

    1998-03-01

    Endotracheal and endobronchial stent implantation has been developed as an effective treatment of benign and malignant airway stenosis and of tracheo- or bronchoesophageal fistulas. The selection of the stent type depends on the kind and site of disease. Chest X-ray and bronchoscopy are the procedures of choice for monitoring of stent position, structure, and function. However, with scintigraphic methods the effects of stent implantation on pulmonary ventilation and perfusion can be assessed non-invasively. The validation of the effect of a stent implantation on mucociliary and tussive clearance remains to be elucidated. (orig.) [Deutsch] Die endotracheale und -bronchiale Stentimplantation wurde in den letzten Jahren als effektive Massnahme bei benignen und malignen Stenosen der Atemwege, drohendem Atemwegsverschluss und bei tracheo- bzw. bronchooesophagealen Fisteln eingefuehrt. Der gewaehlte Stenttyp richtet sich nach dem Implantationsort und den krankheitsbedingten Veraenderungen. Zum Monitoring von Lage, Struktur und Funktion eines Stents dienen Thoraxroentgenaufnahmen und die Bronchoskopie. Nuklearmedizinische Verfahren koennen nicht-invasiv den Effekt der Stenteinlage auf Lungenventilation und -perfusion belegen. Die Validierung des Effekts einer Stentimplantation auf die mukoziliaere und tussive Clearance steht noch aus. (orig.)

  1. Time course of transient cortical scintigraphic defects associated with acute pyelonephritis

    Energy Technology Data Exchange (ETDEWEB)

    Ditchfield, Michael R.; Summerville, Dianne; Cook, David J.; Campo, John F. de [Department of Radiology, Royal Children' s Hospital, Melbourne 3052 (Australia); Grimwood, Keith; Nolan, Terrance M. [Department of General Paediatrics, Royal Children' s Hospital, Melbourne (Australia); Department of Paediatrics, University of Melbourne, Melbourne (Australia); Powell, Harley R. [Department of Nephrology, Royal Children' s Hospital, Melbourne (Australia); Sloane, Robert [Department of General Paediatrics, Royal Children' s Hospital, Melbourne (Australia)

    2002-12-01

    Acute pyelonephritis is distinguished from renal scarring using repeat cortical scintigraphy. The defects of acute pyelonephritis resolve, while those of scars persist. To determine the duration of reversible cortical defects following acute pyelonephritis and the time interval required to differentiate infection from scars. Materials and methods. An observational prospective study of 193 children (386 kidneys) aged less than 5 years following their first proven urinary tract infection (UTI). Renal cortical scintigraphic defects were detected in 112 (29%) kidneys within 15 days of diagnosis. Of these, 95 underwent repeat renal cortical scans 2 years after the UTI, including 50 with additional scans performed within 2-6 months of infection. Of the 50 kidneys undergoing a second renal cortical scan within 2-6 months of the first UTI, 22 (44%) had persistent defects. A third scan was performed on 17 (77%) kidneys after 2 years, by which time defects had resolved in another 8 (47%) kidneys. The predictive value of defects detected within 2-6 months of UTI representing scars is 53% (95% CI 28, 77). Overall, nine (18%) kidneys with initial renal cortical abnormalities had permanent defects. In the 45 kidneys undergoing a second cortical scan more than 6 months after the UTI, 11 (24%) had persistent defects. None of the 95 kidneys undergoing serial scans developed new or larger defects. Renal scars may not be reliably diagnosed by cortical scintigraphy performed within 6 months of UTI because the inflammatory lesions may not have fully resolved. (orig.)

  2. Usefulness of renal scintigraphic scanning in the prognosis of acute renal failure

    International Nuclear Information System (INIS)

    Bernheim, J.; Collard, M.; Westphall, M.; Guey, A.; Traeger, J.

    1976-01-01

    The first results concerning the use of renal scintigraphic scanning using hippuran in acute renal failure (A.R.F.) are presented. The tubular stages of hippuran, extraction and secretion then excretion correspond to phenomena which are normally apparent within the first 10 minutes following the injection of hippuran, also it seemed interesting to study the changes which occur in A.R.F. 18 hospital in-patients with A.R.F. were studied, 10 of them suffering from tubulo-interstitial nephropathy (T.I.N.) 4 with acute glomerulonephritis (A.G.N.), 2 with obstruction of the urinary pathways and 2 with tubular necrosis on underlying chronic renal failure. In the 10 cases of T.I.N. the phenomenon of extraction was evident without any sign of secretion appearing during the 24 minutes of the investigation. No relationship could be found between the scintigram and the rapidity of recovery from A.R.F., but 8/10 recovered satisfactory renal function, the two others died from their disease, the A.R.F. being only secondary. It seems that the presence of an extraction phenomenon, whatever the aetiology of the A.R.F., is a parameter which authorizes the prognosis of a favorable course whereas its absence during the 24mm, of the investigation permits one to envisage an unfavorable course [fr

  3. Results of Chiari pelvic osteotomy for acetabular dysplasia in adults; Association with bone scintigraphic findings

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, Nobuo; Ozono, Kenji; Sugano, Nobuhiko; Takaoka, Kunio; Ono, Hiroo (Osaka Univ. (Japan). Faculty of Medicine)

    1993-02-01

    In an attempt to determine indications of Chiari pelvic osteotomy in acetabular dysplasia, postoperative outcome of hip joint (64 joints) was examined on the basis of findings of bone scintigraphy. The subjects were 61 patients with osteoarthrosis of hip joint who underwent preoperative bone scintigraphy. The follow-up period ranged from 2 years to 9 years and 7 months with a mean of 4 years and 9 months. According to X-ray findings, 37 osteoarthrosis joints were staged as early and 27 as progressive. Preoperative bone scintigraphic findings fell into three: (I) normal or slight hot type (33 joints), (II) hot type at the weighting part (16 joints), and (III) double hot type in the weighting part and inside part (15 joints). None of the patients had severe surgical complications such as deep-seated infection, neuroparalysis and pseudojoint. According to the clinical staging for hip joint function, 7 (47%) of 64 joints were judged as poor after osteotomy, belonging to type III. Deterioration of osteoarthrosis was seen in 11 joints (41%) on X-ray films. Of these, 9 had type III. In conclusion, Chiari pelvic osteotomy should not be indicated when type III is shown on bone scintigrams. (N.K.).

  4. Scintigraphic evaluation of chronic cholecystitis with cholelithiasis using technetium-99m-labelled pyridoxylidene isoleucine

    International Nuclear Information System (INIS)

    Alp, E.; Bekdik, C.F.; Laleli, Y.; Ercan, M.T.

    1981-01-01

    Technetium-99m-labelled pyridoxylidene isoleucine was evaluated in normal subjects as a hepatobiliar scanning agent and in patients with chronic cholecystitis with cholelithiasis. In all the normals and patients the liver function tests (SGOT, SGPT, AP and serum bilirubin) were normal. Scintigraphic studies were performed at 5, 10, 15, 20, 25, 30 and 60 min after IV administration of the agent. In the normal group (seven subjects) liver was visualized at 5 min, the common bile duct and the gall bladder at 5-15 min and the bowel activity within 20 min. In the patient group (15 subjects) the liver and the common bile duct were visualized at the same time as in the normal group but the gall bladder was either visualized later or not at all. The results showed that chronic cholecystitis with cholelithiasis may be diagnosed with 87% accuracy using 99 Tcsup(m)-pyridoxylidene isoleucine cholescintigraphy. Scintigraphy with this agent has also superiority over roentgenologic examination in 20% of the cases. (author)

  5. Gastric emptying and intragastric distribution of lipids in man. A new scintigraphic method of study

    International Nuclear Information System (INIS)

    Jian, R.; Vigneron, N.; Najean, Y.; Bernier, J.J.

    1982-01-01

    We measured gastric emptying of fat and water from a solid-liquid meal in healthy volunteers using a tubeless scintigraphic method. 75 Se glycerol triether, incorporated in butter, was the lipid-phase marker, and /sup 99m/Tcm, ingested with 250 ml water, the non-lipid phase marker. In seven of these subjects we also measured the gastric emptying of solids and liquids with /sup 99m/Tc bound to cooked egg whites as the solid-phase marker and 111 In ingested with 250 ml water as the marker of the solid and aqueous phases. Emptying and intragastric repartition of each marker were measured by detection of radioactivity changes over the abdominal area using a gamma-camera. The stability and the specificity of the labeling was checked for each marker. Mean gastric emptying rate (expressed as percentage ingested marker emptied per hr) of lipids (17.4 +/- 2.4) was much lower than that of the rest of the meal (34.2 +/- 1.8) and slightly, but significantly, lower than that of solids (22.8 +/- 1.8). An intragastric layering of fat above nonlipids was observed only after the first postprandial hour and remained moderate. Thus, lipids are emptied more slowly than any other component of an ordinary meal, and this is not due only to layering of fat above water

  6. Correlation of hepatospleno-scintigraphic findings with HBe antigenicity in chronic hepatitis B

    Energy Technology Data Exchange (ETDEWEB)

    Song, K S; Chun, K S; Chung, S K; Bahk, Y W [Catholic Medical College, Seoul (Korea, Republic of)

    1983-12-15

    Radioimmunoassay plays an important role in diagnosing the hepatitis B and in clinical assessment of the course of the disease as well. Among a number of antigens, antibodies and enzymes related with hepatitis, HBe Ag, DNA polymerase, IgM-HBc-antibody, {delta} Ag have been known as useful indicators of ongoing infectivity of hepatitis B. The present study has been undertaken to correlate the HBe antigenicity with hepatospleno-scintigraphic findings in hepatitis. The study covered a 10 month period from September 1982 through to July 1983. We reviewed and analyzed the hepatospeno-scintgraphic findings and the results of radioimmuassays in 32 patients of chronic hepatitis seen at St. Mary Hospital, Catholic Medical College. Hepatitis B was diagnosed either when HBs Ag was positive or Anti-HBc wa positive even if HBs Ag was negative. We classified the HBe antigenicity into two groups of HBe Ag(+) and HBe(-) and analyzed the scintgraphic findings in terms of liver size, motting, splenomegaly and splenic shift. From the present study, it is concluded that the activity of hepatitis B can not be assessed by the findings of hepatospleno-scintigram so far as the activity is determined on the basis of the positive HBe Ag, which has been believed to indicated continuing viral replication.

  7. Gastric emptying and intragastric distribution of lipids in man. A new scintigraphic method of study

    Energy Technology Data Exchange (ETDEWEB)

    Jian, R.; Vigneron, N.; Najean, Y.; Bernier, J.J.

    1982-08-01

    We measured gastric emptying of fat and water from a solid-liquid meal in healthy volunteers using a tubeless scintigraphic method. /sup 75/Se glycerol triether, incorporated in butter, was the lipid-phase marker, and /sup 99m/Tcm, ingested with 250 ml water, the non-lipid phase marker. In seven of these subjects we also measured the gastric emptying of solids and liquids with /sup 99m/Tc bound to cooked egg whites as the solid-phase marker and /sup 111/In ingested with 250 ml water as the marker of the solid and aqueous phases. Emptying and intragastric repartition of each marker were measured by detection of radioactivity changes over the abdominal area using a gamma-camera. The stability and the specificity of the labeling was checked for each marker. Mean gastric emptying rate (expressed as percentage ingested marker emptied per hr) of lipids (17.4 +/- 2.4) was much lower than that of the rest of the meal (34.2 +/- 1.8) and slightly, but significantly, lower than that of solids (22.8 +/- 1.8). An intragastric layering of fat above nonlipids was observed only after the first postprandial hour and remained moderate. Thus, lipids are emptied more slowly than any other component of an ordinary meal, and this is not due only to layering of fat above water.

  8. Correlation of hepatospleno-scintigraphic findings with HBe antigenicity in chronic hepatitis B

    International Nuclear Information System (INIS)

    Song, K. S.; Chun, K. S.; Chung, S. K.; Bahk, Y. W.

    1983-01-01

    Radioimmunoassay plays an important role in diagnosing the hepatitis B and in clinical assessment of the course of the disease as well. Among a number of antigens, antibodies and enzymes related with hepatitis, HBe Ag, DNA polymerase, IgM-HBc-antibody, δ Ag have been known as useful indicators of ongoing infectivity of hepatitis B. The present study has been undertaken to correlate the HBe antigenicity with hepatospleno-scintigraphic findings in hepatitis. The study covered a 10 month period from September 1982 through to July 1983. We reviewed and analyzed the hepatospeno-scintgraphic findings and the results of radioimmuassays in 32 patients of chronic hepatitis seen at St. Mary Hospital, Catholic Medical College. Hepatitis B was diagnosed either when HBs Ag was positive or Anti-HBc wa positive even if HBs Ag was negative. We classified the HBe antigenicity into two groups of HBe Ag(+) and HBe(-) and analyzed the scintgraphic findings in terms of liver size, motting, splenomegaly and splenic shift. From the present study, it is concluded that the activity of hepatitis B can not be assessed by the findings of hepatospleno-scintigram so far as the activity is determined on the basis of the positive HBe Ag, which has been believed to indicated continuing viral replication

  9. Scintigraphic study of palpable breast nodes with 99m Tc-tetrofosmin

    International Nuclear Information System (INIS)

    Pellini, Marcos Pinto; Fonseca, Lea Mirian Barbosa da; Amarante Junior, Jose Luiz de Medeiros; Fabricio, Maria Ines Menescal

    1998-01-01

    In Brazil, breast carcinoma has the greater incidence among women. In 1996, about 31,210 new cases were diagnosed. The purpose of this study is to determine if 99m technetium-tetrofosmin preferentially concentrates within malignant palpable breast nodes, distinguishing them from the benign lumps. Fifth-four consecutive and unsolicited women, mean age 47.5 +- 10.7 years, with palpable nodes in breast, underwent breast scintigraphy with 99m technetium-tetrofosmin and excisional biopsy or fine needle puncture within interval eight weeks. Histopathologic studies demonstrated 13 cysts, 1 cyst with local inflammation, 11 fibroadenoma, 2 fibrodysplasias, 3 fibroadenomas with high cellularity, 1 fibrocystic change with local inflammation, 23 invasive intraductal carcinomas and 1 invasive lobular carcinoma. The nodes ranged from 10 to 100 mm in greater diameter. The scintigraphic study yielded 30 true-negative cases, 24 true-positives, no false-negative and 1 false-positive. This case was a fibrocystic lump with local inflammation. Two patients had metastases in axillary lymph nodes, well detected in scintigraphy. The statistic analysis showed: sensitivity, 100%; specificity, 96.8%; accuracy, 98.2%; negative predictive value, 100%; positive predictive value, 96.0%. Nonparametric tests of Fisher and Chi-square rejected the antithesis at a confidence interval of 99.9% (p 99m technetium-tetrofosmin preferentially concentrates in malignant palpable breast nodes and can help to distinguish them from the benign tumors with with very high accuracy. (author)

  10. Differentiation of scintigraphic-morphological changes of the thyroid by diffusion techniques

    International Nuclear Information System (INIS)

    Auf Hamada, T.

    1974-01-01

    The essay was based on the question of the possibility of obtaining a diagnostic parameter by determining the thyroidal blood circulation with the aid of gamma-camera examination. A series of confirmed cases of hyperthyreoses, adenomas, cycts, and malignomas was selected trying to distinguish the criteria of the blood circulation of clinically, serologically, and scintigraphically normal organs. The blood circulation of the normal-sized, or slightly enlarged thyroid showed in all cases a normal curve with constant increase, but without a peak during the period of examination (60 sec.). If we look at the curve in the case of hyperthyreosis, we see, in contrast to the normal findings a notably faster accumulation of the nuclide in the thyroid, with a slightly reduced enrichment in the further course of the examination, in comparison to the initial part of the curve. The blood circulation curves of decompensated adenomas show, in contrast to the compensated adenoma, also a faster initial accumulation, in relation to the total height of the impulse, which is quantitatively increased by 1/3. If we compare all adenomas, we see that the curve ascends continously, although only in two of seven cases a peak could be differentiated, which might be due to a faster thyroid clearance. (orig./AJ) [de

  11. Time course of transient cortical scintigraphic defects associated with acute pyelonephritis

    International Nuclear Information System (INIS)

    Ditchfield, Michael R.; Summerville, Dianne; Cook, David J.; Campo, John F. de; Grimwood, Keith; Nolan, Terrance M.; Powell, Harley R.; Sloane, Robert

    2002-01-01

    Acute pyelonephritis is distinguished from renal scarring using repeat cortical scintigraphy. The defects of acute pyelonephritis resolve, while those of scars persist. To determine the duration of reversible cortical defects following acute pyelonephritis and the time interval required to differentiate infection from scars. Materials and methods. An observational prospective study of 193 children (386 kidneys) aged less than 5 years following their first proven urinary tract infection (UTI). Renal cortical scintigraphic defects were detected in 112 (29%) kidneys within 15 days of diagnosis. Of these, 95 underwent repeat renal cortical scans 2 years after the UTI, including 50 with additional scans performed within 2-6 months of infection. Of the 50 kidneys undergoing a second renal cortical scan within 2-6 months of the first UTI, 22 (44%) had persistent defects. A third scan was performed on 17 (77%) kidneys after 2 years, by which time defects had resolved in another 8 (47%) kidneys. The predictive value of defects detected within 2-6 months of UTI representing scars is 53% (95% CI 28, 77). Overall, nine (18%) kidneys with initial renal cortical abnormalities had permanent defects. In the 45 kidneys undergoing a second cortical scan more than 6 months after the UTI, 11 (24%) had persistent defects. None of the 95 kidneys undergoing serial scans developed new or larger defects. Renal scars may not be reliably diagnosed by cortical scintigraphy performed within 6 months of UTI because the inflammatory lesions may not have fully resolved. (orig.)

  12. Similar-Case-Based Optimization of Beam Arrangements in Stereotactic Body Radiotherapy for Assisting Treatment Planners

    Directory of Open Access Journals (Sweden)

    Taiki Magome

    2013-01-01

    Full Text Available Objective. To develop a similar-case-based optimization method for beam arrangements in lung stereotactic body radiotherapy (SBRT to assist treatment planners. Methods. First, cases that are similar to an objective case were automatically selected based on geometrical features related to a planning target volume (PTV location, PTV shape, lung size, and spinal cord position. Second, initial beam arrangements were determined by registration of similar cases with the objective case using a linear registration technique. Finally, beam directions of the objective case were locally optimized based on the cost function, which takes into account the radiation absorption in normal tissues and organs at risk. The proposed method was evaluated with 10 test cases and a treatment planning database including 81 cases, by using 11 planning evaluation indices such as tumor control probability and normal tissue complication probability (NTCP. Results. The procedure for the local optimization of beam arrangements improved the quality of treatment plans with significant differences (P<0.05 in the homogeneity index and conformity index for the PTV, V10, V20, mean dose, and NTCP for the lung. Conclusion. The proposed method could be usable as a computer-aided treatment planning tool for the determination of beam arrangements in SBRT.

  13. Comparing three scheduling methods using BIM models in the Last Planner System

    Directory of Open Access Journals (Sweden)

    Brioso Xavier

    2017-12-01

    Full Text Available This article presents strategies for teaching scheduling methods such as takt-time, flowlines, and point-to-point precedence relations (PTPPRs using build­ing information modeling (BIM models in the Last Planner System. This article is the extended version of the article entitled “Teaching Takt-Time, Flowline and Point-to-point Precedence Relations: A Peruvian Case Study,” which has been published in Procedia Engineering (Vol. 196, 2017, pages 666-673. A case study is conducted in final year students of civil engineering at the Pontifical Catholic University of Peru. The mock-up project is an educational building that has high repetitive processes in the struc­tural works phase. First, traditional tools such as Excel spreadsheets and 2D drawings were used to teach produc­tion system design with takt-time, flowlines, and PTPPR. Second, 3D and 4D models with Revit 2016 and Navis­works 2016 were used to integrate the previous schedules with a BIM model and to identify its strengths and weak­nesses. Finally, Vico Office was used for the automation of schedules and comparison of the methods in 4D and 5D. This article describes the lectures, workshops, and simu­lations employed, as well as the feedback from students and researchers. The success of the teaching strategy is reflected in the survey responses from students and the final perceptions of the construction management tools presented.

  14. Simulation and experimental study on distortion of butt and T-joints using WELD PLANNER

    International Nuclear Information System (INIS)

    Sulaiman, Mohd Shahar; Manurung, Yupiter HP; Rahim, Mohammad Ridzwan Abdul Mohd; Redza, Ridhwan; Lidam, Robert Ngendang Ak.; Abas, Sunhaji Kiyai; Tham, Ghalib; Haruman, Esa; Chau, Chan Yin

    2011-01-01

    This paper investigates the capability of linear thermal elastic numerical analysis to predict the welding distortion that occurs due to GMAW process. Distortion is considered as the major stumbling block that can adversely affect the dimensional accuracy and thus lead to expensive corrective work. Hence, forecast of distortion is crucially needed and ought to be determined in advance in order to minimize the negative effects, improve the quality of welded parts and finally to reduce the production costs. In this study, the welding deformation was simulated by using relatively new FEM software WELD PLANNER developed by ESI Group. This novel Welding Simulation Solution was employed to predict welding distortion induced in butt and T-joints with thickness of 4 mm. Low carbon steel material was used for the simulation and experimental study. A series of experiments using fully automated welding process were conducted for verification purpose to measure the distortion. By comparing between the simulation and experimental results, it was found out that this program code offered fast solution analysis time in estimating weld induced distortion within acceptable accuracy

  15. Simulation and experimental study on distortion of butt and T-joints using WELD PLANNER

    Energy Technology Data Exchange (ETDEWEB)

    Sulaiman, Mohd Shahar; Manurung, Yupiter HP; Rahim, Mohammad Ridzwan Abdul Mohd; Redza, Ridhwan; Lidam, Robert Ngendang Ak.; Abas, Sunhaji Kiyai; Tham, Ghalib [Universiti Teknologi MARA, Kuala Lumpur (Malaysia); Haruman, Esa [Bakrie University, Jakarta (Indonesia); Chau, Chan Yin [ESI Group, Kuala Lumpur (Malaysia)

    2011-10-15

    This paper investigates the capability of linear thermal elastic numerical analysis to predict the welding distortion that occurs due to GMAW process. Distortion is considered as the major stumbling block that can adversely affect the dimensional accuracy and thus lead to expensive corrective work. Hence, forecast of distortion is crucially needed and ought to be determined in advance in order to minimize the negative effects, improve the quality of welded parts and finally to reduce the production costs. In this study, the welding deformation was simulated by using relatively new FEM software WELD PLANNER developed by ESI Group. This novel Welding Simulation Solution was employed to predict welding distortion induced in butt and T-joints with thickness of 4 mm. Low carbon steel material was used for the simulation and experimental study. A series of experiments using fully automated welding process were conducted for verification purpose to measure the distortion. By comparing between the simulation and experimental results, it was found out that this program code offered fast solution analysis time in estimating weld induced distortion within acceptable accuracy.

  16. Beyond hydrology in the sustainability assessment of dams: A planners perspective - The Sarawak experience

    Science.gov (United States)

    Andre, Edward

    2012-01-01

    SummaryThere is increasing concern about the availability of water supplies in developing countries to provide clean drinking water and sanitation as well as providing for irrigation for food security. This has led to hydrologically led investigation to establish the feasibility and storage capacity of potentially new dam sites. This task has become more difficult for hydrologists and others with the uncertainties created by climate change and the measurement of the hydrological, geographical and ecological footprint of new dams. The questions asked by hydrologists are increasingly likely to be required to be cast in terms of the four pillars of sustainability; environmental, economic, social and institutional. Similarly, regional planners have to be more cognisant of the social outcomes of dam development while understanding the wider hydrological context at a watershed and basin level. The paper defines the concept of sustainability assessment in the context of resettlement and analyses its implications for the Bakun Hydro-electric project in Sarawak, Malaysia. Specifically it attempts to address the question of what social sustainability would really mean in the context of communities affected by dam projects, and their catchments using hermeneutics, tradeoffs and offsets. The findings of this question were presented at a hydrological conference held in Santiago in October 2010, based on the outcome of specific questionnaire responses received from indigenous peoples affected by the Bakun Dam hydroelectric project. The paper also offers some insights pertaining to the social sustainability assessment aspects of dams and their catchments.

  17. Visual Data Comm: A Tool for Visualizing Data Communication in the Multi Sector Planner Study

    Science.gov (United States)

    Lee, Hwasoo Eric

    2010-01-01

    Data comm is a new technology proposed in future air transport system as a potential tool to provide comprehensive data connectivity. It is a key enabler to manage 4D trajectory digitally, potentially resulting in improved flight times and increased throughput. Future concepts with data comm integration have been tested in a number of human-in-the-loop studies but analyzing the results has proven to be particularly challenging because future traffic environment in which data comm is fully enabled has assumed high traffic density, resulting in data set with large amount of information. This paper describes the motivation, design, current and potential future application of Visual Data Comm (VDC), a tool for visualizing data developed in Java using Processing library which is a tool package designed for interactive visualization programming. This paper includes an example of an application of VDC on data pertaining to the most recent Multi Sector Planner study, conducted at NASA s Airspace Operations Laboratory in 2009, in which VDC was used to visualize and interpret data comm activities

  18. Imaging reporter gene for monitoring gene therapy

    International Nuclear Information System (INIS)

    Beco, V. de; Baillet, G.; Tamgac, F.; Tofighi, M.; Weinmann, P.; Vergote, J.; Moretti, J.L.; Tamgac, G.

    2002-01-01

    Scintigraphic images can be obtained to document gene function at cellular level. This approach is presented here and the use of a reporter gene to monitor gene therapy is described. Two main ways are presented: either the use of a reporter gene coding for an enzyme the action of which will be monitored by radiolabeled pro-drug, or a cellular receptor gene, the action of which is documented by a radio labeled cognate receptor ligand. (author)

  19. Objective method to report planner-independent skin/rib maximal dose in balloon-based high dose rate (HDR) brachytherapy for breast cancer

    International Nuclear Information System (INIS)

    Kim, Yongbok; Trombetta, Mark G.

    2011-01-01

    Purpose: An objective method was proposed and compared with a manual selection method to determine planner-independent skin and rib maximal dose in balloon-based high dose rate (HDR) brachytherapy planning. Methods: The maximal dose to skin and rib was objectively extracted from a dose volume histogram (DVH) of skin and rib volumes. A virtual skin volume was produced by expanding the skin surface in three dimensions (3D) external to the breast with a certain thickness in the planning computed tomography (CT) images. Therefore, the maximal dose to this volume occurs on the skin surface the same with a conventional manual selection method. The rib was also delineated in the planning CT images and its maximal dose was extracted from its DVH. The absolute (Abdiff=|D max Man -D max DVH |) and relative (Rediff[%]=100x(|D max Man -D max DVH |)/D max DVH ) maximal skin and rib dose differences between the manual selection method (D max Man ) and the objective method (D max DVH ) were measured for 50 balloon-based HDR (25 MammoSite and 25 Contura) patients. Results: The average±standard deviation of maximal dose difference was 1.67%±1.69% of the prescribed dose (PD). No statistical difference was observed between MammoSite and Contura patients for both Abdiff and Rediff[%] values. However, a statistically significant difference (p value max >90%) compared with lower dose range (D max <90%): 2.16%±1.93% vs 1.19%±1.25% with p value of 0.0049. However, the Rediff[%] analysis eliminated the inverse square factor and there was no statistically significant difference (p value=0.8931) between high and low dose ranges. Conclusions: The objective method using volumetric information of skin and rib can determine the planner-independent maximal dose compared with the manual selection method. However, the difference was <2% of PD, on average, if appropriate attention is paid to selecting a manual dose point in 3D planning CT images.

  20. The role of energy planners in open-free market conditions

    International Nuclear Information System (INIS)

    Alminana, D. G.

    2003-01-01

    The evolution of the demand for electricity and natural gas usually follows seasonal patterns. In Mediterranean areas, in summer, a sharp increase in electricity needs in residential and commercial buildings coincides with a marked decrease in natural gas consumption. Air-conditioning systems are an increasingly significant factor in peak electricity demand in premises of all economic areas, particularly residential and commercial but also industrial sectors. Efforts made in recent years regarding the development of low cost air-conditioning equipment have produced in turn an increasing number of shortages due to lack of capacity in the production-transmission-distribution chain. Recent examples in Barcelona (June 2003) or Mallorca (July 2003) are just a reference for an ever-increasing problem. In open-free market conditions, how can this situation be overcome? Energy suppliers adopt strategies of Demand Side Management (DSM) in order to reduce negative impact of load curves which are not 'flat enough'. However, negative impacts are mainly seen in terms of economic operation, ignoring other effects such as energy or environmental collateral effects. From our point of view, Integrated Resources Planning (IRP) is a more powerful tool to take into account all three effects: economic, energy and environmental. IRP cannot be carried out by single energy suppliers, only by an Energy Planner. Two specific technologies can help balance energy loads from excess power demand (peak shaving) and reduced gas consumption (valley filling) in summer: High Efficiency Cogeneration / Trigeneration; High Efficiency Gas-Based Air-Conditioning. Recent COM(2003)416 final Directive 'on the promotion of cogeneration based on a useful heat demand in the internal energy market' (Brussels, July 23, 2003) can be adopted as a confirmation of the above issues. (author)

  1. The Last Planner System Style of Planning: Its Basis in Learning Theory

    Directory of Open Access Journals (Sweden)

    Bo Terje Kalsaas

    2012-07-01

    Full Text Available The objective of this article is to contribute to creating a better understanding of the Last Planner System (LPS – which is associated with Lean Construction – in the light of the learning processes at the basis of knowledge development, and of change and innovation. Founded on a theoretical discussion, three research questions are asked, namely: In what ways can the LPS be expected to alter the learning arenas compared to conventional project management in construction; according to learning theory, what are the main challenges associated with implementing the LPS; and, finally, what kind of learning can be linked to an implemented LPS that functions as intended? The implementation of the LPS is shown to require substantial changes to the technical-organisational learning arena. In order for the implementation to be successful, the work identity has to alter on the individual level so that an overlap occurs with the new work practices prescribed by the LPS. The LPS has an inbuilt experiential learning cycle, and provides a good starting point for single-loop learning, as well as for simple forms of double-loop learning (“routinized learning capability”. However, it is argued that the LPS understood as experiential learning has clear limitations with regard to “evolutionary learning capability”. This is amplified by the context project organisation provides. In terms of theoretical implications, this article promotes an understanding of the planning process informed by the theory describing it as an experiential learning cycle. The conceptualisation which separates the LPS from conventional production control theory is critiqued. Finally, it is argued that an understanding of the LPS grounded in learning theory will improve the possibilities for successful implementation and maximise the learning effects.

  2. Leukocyte scintigraphy: correlation of serial scintigraphic findings and clinical progression of inflammatory bowel disease

    International Nuclear Information System (INIS)

    Ho, Y.; Kelly, M.J.; Kaliff, V.

    1997-01-01

    Full text: This study was performed (a) to determine whether the clinical progress of individual patients with inflammatory bowel disease mirrored changes in leukocyte scans, and (b) to assess the reasons for significant discrepancies. Two nuclear medicine physicians reviewed 44 white cell scans in 20 consecutive patients (4 males, 18 females) who were referred for two or more leukocyte scans (using either the 111 In Oxine or 99m Tc HMPAO labelling methods) by three gastroenterologists between 1 January 1992 and 1 June 1996. The sequential scanpairs (range 2-18 months apart) were classified by consensus reading as showing no change, more severe or less severe disease. Questionnaires were sent to the referring gastroenterologists to determine whether the overall clinical status of each patient was unchanged, better or worse in the interval between the two scans. There was complete agreement between clinical and scintigraphic assessment in 45% (10/22) of the study pairs. Review of responses of the three individual gastroenterologists showed a wide range of agreement (4/4, 4/5, 2/13). Review of data showed that most disagreement was based on subjective clinical assessment, and hence of uncertain significance. In two patients, however, potentially preventable false negative leukocyte scans occurred in patients with active proctitis. This may be overcome by rigorous attention to ensure complete emptying of radioactivity from the bladder when 99m Tc HMPAO is used. It was concluded that serial leukocyte scans add to clinical assessment but careful technique is needed to avoid false negative scans in the rectum

  3. Thermosetting gels with modulated gelation temperature for ophthalmic use: the rheological and gamma scintigraphic studies.

    Science.gov (United States)

    Wei, Gang; Xu, Hui; Ding, Ping Tian; Li, San Ming; Zheng, Jun Min

    2002-09-18

    For ophthalmic drug delivery, Pluronic F127 solutions have a phase transition temperature too low for them to be instilled into the eye at room temperature. Refrigerator storage is usually required to make administration easier, whereas the potential irritation of cold to the sensitive ocular tissues may result in poor topical bioavailability. The purpose of this study is to develop a thermosetting gel with a suitable phase transition temperature by combining Pluronic analogs and to examine the influence of incorporating mucoadhesive polysaccharide, sodium hyaluronate (HA-Na), on the ocular retention of the gel. Dynamic rheological method and single photon emission computing tomography (SPECT) technique were used to ex/in vivo evaluate the thermosetting gels, respectively. An optimized formulation containing 21% F127 and 10% F68 increased the phase transition temperature by 9 degrees C as evaluated by elasticity modulus compared to that of individual 21% F127 solution. Rheological behaviors of the Pluronic solutions showed that the combined Pluronic formulation was free flowing liquid below 25 degrees C and converted to a firm gel under the physiological condition. Furthermore, this formulation possessed the highest viscosity both before and after tear dilution at 35 degrees C. Gamma scintigraphic data demonstrated that the clearance of the thermosetting gel labeled with 99mTc-DTPA was significantly delayed with respect to the phosphate buffered solution, and at least a threefold increase of the corneal residence time was achieved. However, no further improvement in the ocular retention was observed when adding HA-Na into the thermosetting gel due to the substantially decreased gel strength. Copyright 2002 Elsevier Science B.V.

  4. Scintigraphic evaluation of osteoblastic activity in extraction sockets treated with platelet-rich fibrin.

    Science.gov (United States)

    Gürbüzer, Bahadir; Pikdöken, Levent; Tunali, Mustafa; Urhan, Muammer; Küçükodaci, Zafer; Ercan, Feriha

    2010-05-01

    To evaluate the effect of platelet-rich fibrin (PRF) on the early bone healing process with bone scintigraphy based on technetium-99m methylene diphosphonate uptake in third molar extraction sockets. Fourteen patients with bilaterally soft tissue impacted third mandibular molars were included in the study. The right and left impacted third molars were surgically extracted in the same session. PRF was randomly administered into one of the extraction sockets, whereas the contralateral sockets were left without treatment. Four weeks after surgery, scintigrams were obtained to evaluate scintigraphic differences between PRF-treated and non-PRF-treated sockets. After completion of the clinical study, PRF samples were evaluated by light and scanning electron microscopy. The average increase in technetium-99m methylene diphosphonate uptake as an indication of enhanced bone healing did not differ significantly between PRF-treated and non-PRF-treated sockets 4 weeks postoperatively (P > .05). Abundant fibrin and inflammatory cells were observed by light microscopic examination of PRF samples. Scanning electron microscopic analysis of PRF revealed the existence of platelet aggregates in a fibrin network and crystalline particles on the outer surface of PRF. PRF might not lead to enhanced bone healing in soft tissue impacted mandibular third molar extraction sockets 4 weeks after surgery. PRF exhibits the potential characteristics of an autologous fibrin matrix. However, whether the presence of crystal-like particles on the outer surface of PRF alters bone healing should be investigated further. Copyright 2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  5. Comparison Of Dimercaptosuccinic Acid Scintigraphic And Voiding Cystourethrographic Findings In Patient With Acute Pyelonephritis

    Directory of Open Access Journals (Sweden)

    Fahimi P

    2003-11-01

    Full Text Available Acute Pyelonephritis (APN is one of the most common bacterial infections seen in children that may lead to renal scarring. Vesicoureteral reflux (VUR is an important risk factor of renal damage but not the only one. Materials and Methods: In order to determine the association between dimercaptosuccinic acid (DMSA scintigraphic and voiding cystourethrographic findings, a retrospective study was performed on 50 children (100 renal units with APN that had been admitted to Bahrami Hospital from 1995 through 1998. Voiding cystourethrography (VCUG and DMSA scan were performed in all patients within 1 to 2 weeks after termination of treatment and a second scan was performed 6 months later in patients whose kidneys showed cortical defects in the first one. The grade of reflux was based on international reflux classification (I-V. The DMSA scans were considered abnormal if one or more areas of decreased cortical uptake were noted (cortical defect. The scar was defined as persistence of these defects in the second scan. DMSA cortical defect and VUR were demonstrated in 42 (42% and 26 (26% of renal units respectively."nResults: Fourteen out of 26 renal units (54% with reflux had cortical defects and 28 out of 74 renal units (38% without reflux had cortical defects (P=0.15. Permanent renal scarring was noted in 25/ 42 of renal units (62 % in second scan. Conclusion: It seems that VCUG alone is insufficient as a screening modality to identity those kidneys at risk of damage and DMSA scan may provide additional information about this."n 

  6. Normal Values of Tissue-Muscle Perfusion Indexes of Lower Limbs Obtained with a Scintigraphic Method.

    Science.gov (United States)

    Manevska, Nevena; Stojanoski, Sinisa; Pop Gjorceva, Daniela; Todorovska, Lidija; Miladinova, Daniela; Zafirova, Beti

    2017-09-01

    Introduction Muscle perfusion is a physiologic process that can undergo quantitative assessment and thus define the range of normal values of perfusion indexes and perfusion reserve. The investigation of the microcirculation has a crucial role in determining the muscle perfusion. Materials and method The study included 30 examinees, 24-74 years of age, without a history of confirmed peripheral artery disease and all had normal findings on Doppler ultrasonography and pedo-brachial index of lower extremity (PBI). 99mTc-MIBI tissue muscle perfusion scintigraphy of lower limbs evaluates tissue perfusion in resting condition "rest study" and after workload "stress study", through quantitative parameters: Inter-extremity index (for both studies), left thigh/right thigh (LT/RT) left calf/right calf (LC/RC) and perfusion reserve (PR) for both thighs and calves. Results In our investigated group we assessed the normal values of quantitative parameters of perfusion indexes. Indexes ranged for LT/RT in rest study 0.91-1.05, in stress study 0.92-1.04. LC/RC in rest 0.93-1.07 and in stress study 0.93-1.09. The examinees older than 50 years had insignificantly lower perfusion reserve of these parameters compared with those younger than 50, LC (p=0.98), and RC (p=0.6). Conclusion This non-invasive scintigraphic method allows in individuals without peripheral artery disease to determine the range of normal values of muscle perfusion at rest and stress condition and to clinically implement them in evaluation of patients with peripheral artery disease for differentiating patients with normal from those with impaired lower limbs circulation.

  7. Scintigraphic Profile of Thyrotoxicosis Patients and Correlation with Biochemical and Sonological Findings.

    Science.gov (United States)

    Avs, Anil Kumar; Mohan, Abhish; Kumar, P G; Puri, Pankaj

    2017-05-01

    Thyrotoxicosis is a spectrum of disorder with a rather common clinical presentation with different aetiologies. The aetiological diagnosis is important as the management differs. It is essential to accurately diagnose the cause before starting treatment. Scintigraphy of thyroid helps in differentiating accurately the various causes. USG is routinely being advocated and T3/T4 ratio has also been used. This study aims to evaluate the scintigraphic profile of thyrotoxicosis patients and to correlate biochemical and USG findings with scintigraphy. A total of 60 newly diagnosed thyrotoxicosis patients based on biochemical reports were included in the study. They underwent further evaluation with ultrasonography and 99mTc scintigraphy. Of 60 patients of thyrotoxicosis, 45 cases were of Grave's disease, 10 cases were of thyroiditis and five cases were of Toxic Multinodular Goiter (MNG). The clinical characteristics were helpful in establishing the diagnosis in only six (10%) patients who presented with classic features of Grave's disease with ophthalmopathy. T3/T4 ratio greater than 20 was seen only in 29 (66%) patients of Grave's disease and also in three (33.33%) of thyroiditis patients. USG had a sensitivity and specificity of 81.82% and 93.75% in diagnosing Graves' disease and 100% and 82.4% in diagnosing thyroiditis respectively. Clinical findings do not help in accurately delineating aetiological diagnosis of thyrotoxicosis. Serum T3/T4 ratio when used as a criterion has marked overlap between the various conditions causing thyrotoxicosis. USG has reasonable sensitivity however, misses many cases of early Grave's disease. Follow up scintigraphy helps in a small population with resolving thyroiditis or early Grave's disease where the initial scintiscan is normal or inconclusive.

  8. Local bone pain and osseous scintigraphic findings in patients with metastatic bone tumor

    International Nuclear Information System (INIS)

    Imaeda, Takeyoshi; Iinuma, Gen; Hirota, Keiichi; Inoue, Akemi; Sone, Yasuhiro; Seki, Matsuzo; Suzuki, Masao; Doi, Hidetaka

    1988-01-01

    Local bone pain and osseous scintigraphic findings were evaluated in patients with cancer of the lung, breast or prostate. (1) In 77-92% out of the patients with local pain, metastatic bone lesions were detected. (2) The sacrum and scapulae were the frequent sites of pain as estimated from the metastatic bone lesions. On the other hand, the incidence of pain was low in the ribs, cervical vertebrae, skull and femurs. (3) When calculated by the weight of red bone marrow, the most likely sites for bone metastases consisted of the scapulae, clavicles, sternum, humeri, ribs and cervical vertebrae, somewhat different from previous reports. Those bones involved were all proximate to the heart. (4) Extensive bone metastases were already detected in more than 50% of patients who complain of pain in the metastatic bone lesion. On the other hand, extensive bone metastases occurred in less than 6% of patients who didn't complain of pain. (5) The appearance of pain in the metastatic bone lesion was earlier in only 3% and was later in 71% than the detection of abnormal radioisotope accumulation on scintigram. (6) Majority of the patients with pain in the metastatic bone lesion showed a high degree of abnormal radioisotope accumulation which measured more than 5 cm in diameter on scintigram. On the other hand, the abnormal radioisotope accumulation in most of patients without pain was mild and mostly measured less than 5 cm in diameter. (7) The positive rate of bone metastasis amounted to 29% by plain X-ray and 41% by local bone pain as compaired to positive bone scintigram. (author)

  9. Local bone pain and osseous scintigraphic findings in patients with metastatic bone tumor

    Energy Technology Data Exchange (ETDEWEB)

    Imaeda, Takeyoshi; Iinuma, Gen; Hirota, Keiichi; Inoue, Akemi; Sone, Yasuhiro; Seki, Matsuzo; Suzuki, Masao; Doi, Hidetaka

    1988-12-01

    Local bone pain and osseous scintigraphic findings were evaluated in patients with cancer of the lung, breast or prostate. (1) In 77-92% out of the patients with local pain, metastatic bone lesions were detected. (2) The sacrum and scapulae were the frequent sites of pain as estimated from the metastatic bone lesions. On the other hand, the incidence of pain was low in the ribs, cervical vertebrae, skull and femurs. (3) When calculated by the weight of red bone marrow, the most likely sites for bone metastases consisted of the scapulae, clavicles, sternum, humeri, ribs and cervical vertebrae, somewhat different from previous reports. Those bones involved were all proximate to the heart. (4) Extensive bone metastases were already detected in more than 50% of patients who complain of pain in the metastatic bone lesion. On the other hand, extensive bone metastases occurred in less than 6% of patients who didn't complain of pain. (5) The appearance of pain in the metastatic bone lesion was earlier in only 3% and was later in 71% than the detection of abnormal radioisotope accumulation on scintigram. (6) Majority of the patients with pain in the metastatic bone lesion showed a high degree of abnormal radioisotope accumulation which measured more than 5 cm in diameter on scintigram. On the other hand, the abnormal radioisotope accumulation in most of patients without pain was mild and mostly measured less than 5 cm in diameter. (7) The positive rate of bone metastasis amounted to 29% by plain X-ray and 41% by local bone pain as compaired to positive bone scintigram.

  10. The hypofunctioning thyroid nodule: Radiography, computed tomography (CT) and magnetic resonance imaging (MRI)

    International Nuclear Information System (INIS)

    Dorn, R.; Wagner-Manslau, C.

    1992-01-01

    The hyperfunctioning thyroid nodule is a scintigraphic diagnosis by definition. Its dignity is assessed by fine needle aspiration biopsy. Radiographic methods and magnetic resonance imaging (MRI) are no primary tools in diagnosis of the hypofunctioning thyroid nodule but may reveal additional information, especially in cases of retrosternal goiter and thyroid malignomas. (orig.) [de

  11. Technetium-99m biliary imaging in pediatric surgical problems

    International Nuclear Information System (INIS)

    Sty, J.R.; Glicklich, M.; Babbitt, D.P.; Starshak, R.J.

    1981-01-01

    The results of scintigraphic imaging of the hepatobiliary system with 99mTc-PIPIDA (IDA derivative p-isopropylacetanilidoiminodiacetic acid) in forty children are reported. 99mTc-PIPIDA imaging is a noninvasive, rapid, safe examination that provides both functional and anatomical information about the hepatobiliary system. Although interpretation is limited by elevated direct serum bilirubin, this agent allows diagnostic information to be obtained with direct serum bilirubin levels up to 8 mg/dl

  12. Scintigraphic observation of the course of secondary fracture healing with and without ultrasonic stimulation in animal experiments

    International Nuclear Information System (INIS)

    Klug, W.; Franke, W.G.; Schulze, M.

    1986-01-01

    Secondary fracture healing was studied in the course of closed lower leg fractures in rabbit fracture models by /sup 99m/Tc scintiscanning. The ROI activity quotient increased significantly up to the maximum value, Q = 6.44 on the 14th day after fracture. 61 fractures of the lower leg were treated by ultrasonics from the 14th to the 28th day after fracture. These stimulated fractures showed a biologic healing already on the 168th day. Fractures untreated with ultrasonics could not be proved any more scintigraphically only after the 203rd day after fracture. (author)

  13. Raccoon eyes and the MIBG super scan: scintigraphic signs of neuroblastoma in a case of suspected child abuse

    International Nuclear Information System (INIS)

    Bohdiewicz, P.J.; Gallegos, E.; Fink-Bennett, D.

    1995-01-01

    The authors report on an infant suspected of having been abused, who presented with periorbital edema and ecchymoses (clinial 'raccoon eyes'). The pattern of the nuclear medicine bone scan suggested neuroblastoma rather than trauma. Both the bone scan and the subsequent MIBG scan revealed multiple abnormalities, including markedly increased activity around the orbits, that we termed the 'scintigraphic raccoon eyes' sign. In addition, the grossly abnormal MIBG scan demonstrated avid uptake of MIBG throughout the entire skeleton with essentially complete absence of visualization of the liver and heart (the 'MIBG super scan'). These signs have not previously been described in an infant or a child with neuroblastoma. (orig.)

  14. Raccoon eyes and the MIBG super scan: scintigraphic signs of neuroblastoma in a case of suspected child abuse

    Energy Technology Data Exchange (ETDEWEB)

    Bohdiewicz, P.J. [Nuclear Medicine Dept., William Beaumont Hospital, Royal Oak, MI (United States); Gallegos, E. [Nuclear Medicine Dept., William Beaumont Hospital, Royal Oak, MI (United States); Fink-Bennett, D. [Nuclear Medicine Dept., William Beaumont Hospital, Royal Oak, MI (United States)

    1995-11-01

    The authors report on an infant suspected of having been abused, who presented with periorbital edema and ecchymoses (clinial `raccoon eyes`). The pattern of the nuclear medicine bone scan suggested neuroblastoma rather than trauma. Both the bone scan and the subsequent MIBG scan revealed multiple abnormalities, including markedly increased activity around the orbits, that we termed the `scintigraphic raccoon eyes` sign. In addition, the grossly abnormal MIBG scan demonstrated avid uptake of MIBG throughout the entire skeleton with essentially complete absence of visualization of the liver and heart (the `MIBG super scan`). These signs have not previously been described in an infant or a child with neuroblastoma. (orig.)

  15. A follow-up study of environmental and biologic determinants of fertility among 430 Danish first-pregnancy planners

    DEFF Research Database (Denmark)

    Bonde, J P; Hjollund, N H; Jensen, T K

    1998-01-01

    This paper presents design and methods of a follow-up study of fecundability (defined as the probability of conception during one menstrual cycle) in first-pregnancy planners. We recruited 430 couples by postal letter among 52,255 members of four trade unions. Couples without earlier reproductive......-18%). Among all conceptions the proportion of early embryonal loss was 17% (95% CI 12-22%). This study demonstrates the feasibility of a prospective study of fertility and that the established study base can provide useful information on environmental risk to subfertility.......This paper presents design and methods of a follow-up study of fecundability (defined as the probability of conception during one menstrual cycle) in first-pregnancy planners. We recruited 430 couples by postal letter among 52,255 members of four trade unions. Couples without earlier reproductive...

  16. Enhancing Linkages Between Healthy Diets, Local Agriculture, and Sustainable Food Systems: The School Meals Planner Package in Ghana.

    Science.gov (United States)

    Fernandes, Meenakshi; Galloway, Rae; Gelli, Aulo; Mumuni, Daniel; Hamdani, Salha; Kiamba, Josephine; Quarshie, Kate; Bhatia, Rita; Aurino, Elisabetta; Peel, Francis; Drake, Lesley

    2016-12-01

    Interventions that enhance linkages between healthy diets and local agriculture can promote sustainable food systems. Home-grown school feeding programs present a promising entry point for such interventions, through the delivery of nutritious menus and meals. To describe the adaptation of the School Meals Planner Package to the programmatic and environmental reality in Ghana during the 2014 to 2015 school year. Guided by a conceptual framework highlighting key considerations and trade-offs in menu design, an open-source software was developed that could be easily understood by program implementers. Readily available containers from markets were calibrated into "handy measures" to support the provision of adequate quantities of food indicated by menus. Schools and communities were sensitized to the benefits of locally sourced, nutrient-rich diets. A behavior change communication campaign including posters and songs promoting healthy diets was designed and disseminated in schools and communities. The School Meals Planner Package was introduced in 42 districts in Ghana, reaching more than 320 000 children. Monitoring reports and feedback on its use were positive, demonstrating how the tool can be used by planners and implementers alike to deliver nutritious, locally-sourced meals to schoolchildren. The value of the tool has been recognized at the highest levels by Ghana's government who have adopted it as official policy. The School Meals Planner Package supported the design of nutritious, locally sourced menus for the school feeding program in Ghana. The tool can be similarly adapted for other countries to meet context-specific needs. © The Author(s) 2016.

  17. Scintigraphic criteria for administration of therapeutic activities of 131I for ablation of residual thyroid tissue in patients with differentiated thyroid cancer

    International Nuclear Information System (INIS)

    Dzhuzha, D.A.

    2003-01-01

    With the aim to determinate the optical scintigraphic criteria of radioablation of the small parts of residual thyroid tissue (RTT) after a thyroidectomy the results of postoperative monitoring of 29 women aged 23-60 with differentiated thyroid cancer, who did not get the radioiodine therapy, were analyzed. At the single postoperative scintigraphy with 131 I the optimal scintigraphic criteria for radioablation are the relative level of 131 I accumulation in RTT and the relative specific volume activity in RTT. At the values of these indices below 0.21% and 0.16%/sm 3 , respectively, only suppressive thyroid hormone therapy and standard monitoring are recommended

  18. Effects of Transparency on Pilot Trust and Agreement in the Autonomous Constrained Flight Planner

    Science.gov (United States)

    Sadler, Garrett; Battiste, Henri; Ho, Nhut; Hoffmann, Lauren; Lyons, Joseph; Johnson, Walter; Shively, Robert; Smith, David

    2016-01-01

    We performed a human-in-the-loop study to explore the role of transparency in engendering trust and reliance within highly automated systems. Specifically, we examined how transparency impacts trust in and reliance upon the Autonomous Constrained Flight Planner (ACFP), a critical automated system being developed as part of NASA's Reduced Crew Operations (RCO) Concept. The ACFP is designed to provide an enhanced ground operator, termed a super dispatcher, with recommended diversions for aircraft when their primary destinations are unavailable. In the current study, 12 commercial transport rated pilots who played the role of super dispatchers were given six time-pressured all land scenarios where they needed to use the ACFP to determine diversions for multiple aircraft. Two factors were manipulated. The primary factor was level of transparency. In low transparency scenarios the pilots were given a recommended airport and runway, plus basic information about the weather conditions, the aircraft types, and the airport and runway characteristics at that and other airports. In moderate transparency scenarios the pilots were also given a risk evaluation for the recommended airport, and for the other airports if they requested it. In the high transparency scenario additional information including the reasoning for the risk evaluations was made available to the pilots. The secondary factor was level of risk, either high or low. For high-risk aircraft, all potential diversions were rated as highly risky, with the ACFP giving the best option for a bad situation. For low-risk aircraft the ACFP found only low-risk options for the pilot. Both subjective and objective measures were collected, including rated trust, whether the pilots checked the validity of the automation recommendation, and whether the pilots eventually flew to the recommended diversion airport. Key results show that: 1) Pilots trust increased with higher levels of transparency, 2) Pilots were more likely to

  19. Climate Resiliency Planning: Making Extreme Event Science Useful for Managers and Planners in Northern Nevada

    Science.gov (United States)

    McCarthy, M.; Kenneston, A.; Wall, T. U.; Brown, T. J.; Redmond, K. T.

    2014-12-01

    Effective climate resiliency planning at the regional level requires extensive interactive dialogue among climate scientists, emergency managers, public health officials, urban planners, social scientists, and policy makers. Engaging federal, tribal, state, local governments and private sector business and infrastructure owners/operators in defining, assessing and characterizing the impacts of extreme events allows communities to understand how different events "break the system" forcing local communities to seek support and resources from state/federal governments and/or the private sector and what actions can be taken proactively to mitigate consequences and accelerate recovery. The Washoe County Regional Resiliency Study was prepared in response to potential climate variability related impacts specific to the Northern Nevada Region. The last several decades have seen dramatic growth in the region, coupled with increased resource demands that have forced local governments to consider how those impacts will affect the region and may, in turn, impact the region's ability to provide essential services. The Western Regional Climate Center of the Desert Research Institute provided a synthesis of climate studies with predictions regarding plausible changes in the local climate of Northern California and Nevada for the next 50 years. In general, these predictions indicate that the region's climate is undergoing a gradual shift, which will primarily affect the frequency, amount, and form of precipitation in the Sierra Nevada and Great Basin. Changes in water availability and other extreme events may have serious and long lasting effects in the Northern Nevada Region, and create a variety of social, environmental and economic concerns. A range of extreme events were considered including Adverse Air Quality, Droughts, Floods, Heat Waves, High Wind, Structure Fires, Wildland Fires, and Major Winter Storms. Due to the complexity of our climate systems, and the difficulty in

  20. Two-dimensional fusion imaging of planar bone scintigraphy and radiographs in patients with clinical scaphoid fracture: an imaging study

    DEFF Research Database (Denmark)

    Henriksen, Otto Mølby; Lonsdale, Markus Georg; Jensen, T D

    2009-01-01

    . Bone scintigraphy is highly sensitive for the detection of fractures, but exact localization of scintigraphic lesions may be difficult and can negatively affect diagnostic accuracy. PURPOSE: To investigate the influence of image fusion of planar bone scintigraphy and radiographs on image interpretation......BACKGROUND: Although magnetic resonance imaging (MRI) is now considered the gold standard in second-line imaging of patients with suspected scaphoid fracture and negative radiographs, bone scintigraphy can be used in patients with pacemakers, metallic implants, or other contraindications to MRI....... CONCLUSION: Image fusion of planar bone scintigrams and radiographs has a significant influence on image interpretation and increases both diagnostic confidence and interobserver agreement....

  1. Relation between myocardial response to dobutamine stress and sympathetic nerve activation in patients with idiopathic dilated cardiomyopathy. A comparison of 123I-MIBG scintigraphic and echocardiographic data

    International Nuclear Information System (INIS)

    Naruse, Hitoshi; Arii, Tohru; Kondo, Tomohiro

    2000-01-01

    It is likely that a close association exists between findings obtained by two methods: dobutamine stress echocardiography and 123 I-MIBG scintigraphy. Both of these methods are associated with β-adrenergic receptor mechanisms. This study was conducted to demonstrate the relation between myocardial response to dobutamine stress and sympathetic nerve release of norepinephrine in the failing heart. In 12 patents with heart failure due to idiopathic dilated cardiomyopathy, the myocardial effects of dobutamine stress were evaluated by low-dose dobutamine stress echocardiography; and sympathetic nerve function was evaluated by scintigraphic imaging with iodine-123[ 123 I]meta-iodobenzylguanidine (MIBG), an analogue of norepinephrine. Echocardiography provided quantitative assessment of wall motion and left ventricular dilation; radiotracer studies with 123 I-MIBG provided quantitative assessment of the heart-to-mediastinum (H/M) uptake ratio and washout rate. Results showed that H/M correlated with baseline wall motion (r=0.682, p=0.0146), wall motion after dobutamine stress (r=0.758, p=0.0043), the change in wall motion (r=0.667, p=0.0178), and with left ventricular diastolic diameter (r=0.837, p=0.0007). In addition, the 123 I-MIBG washout rate correlated with baseline wall motion (r=0.608, p=0.0360), wall motion after dobutamine stress (r=0.703, p=0.0107), and with the change in wall motion (r=0.664, p=0.0185). Wall motion, especially in the myocardial response to dobutamine stress, is related to sympathetic nerve activity in heart failure. (author)

  2. [Magnetic resonance imaging of tibial periostitis].

    Science.gov (United States)

    Meyer, X; Boscagli, G; Tavernier, T; Aczel, F; Weber, F; Legros, R; Charlopain, P; Martin, J P

    1998-01-01

    Tibial periostitis frequently occurs in athletes. We present our experience with MRI in a series of 7 patients (11 legs) with this condition. The clinical presentation and scintigraphic scanning suggested the diagnosis. MRI exploration of 11 legs demonstrated a high band-like juxta-osseous signal enhancement of SE and IR T2 weighted sequences in 6 cases, a signal enhancement after i.v. contrast administration in 4. Tibial periostitis is a clinical diagnosis and MRI and scintigraphic findings can be used to assure the differential diagnosis in difficult cases with stress fracture. MRI can visualize juxta-osseous edematous and inflammatory reactions and an increased signal would appear to be characteristic when the band-like image is fixed to the periosteum.

  3. Scintigraphic calf perfusion symmetry after exercise and prediction of cardiovascular events: One stone to kill two birds?

    International Nuclear Information System (INIS)

    Tellier, Philippe; Lecouffe, Pascal; Zureik, Mahmoud

    2007-01-01

    Background: Peripheral arterial disease (PAD) is commonly associated with a high cardiovascular mortality and morbidity as a marker of plurifocal atherosclerosis. Whether exercise thallium perfusion muscular asymmetry in the legs associated with PAD has prognostic value is unknown. Such a hypothesis was evaluated in a prospective study which remains the gold standard in clinical research. Methods and results: Scintigraphic calf perfusion symmetry after exercise (SCPSE) was measured at the end of a maximal or symptom-limited treadmill exercise test in 358 patients with known or suspected coronary artery disease (CAD). During the follow-up period (mean 85.3±32.8 months), 93 cardiovascular events and deaths (incident cases) occurred. Among those incident cases, the percentage of subjects with higher SCPSE values (third tertile) was 45.2%, versus 29.1% in controls (lower tertiles) (p=0.005). In stepwise multivariate analysis performed with the Cox proportional hazards model, previous CAD and SCPSE were the only significant independent predictors of prognosis. The multivariate relative risk of cardiovascular death or event in subjects with higher values of SCPSE was 1.94 (95% CI: 1.15-3.21; p<0.01). Conclusions: Scintigraphic calf perfusion asymmetry after exercise was independently associated with incident cardiovascular events in high-risk subjects. This index, which is easily and quickly calculated, could be used for evaluation of cardiovascular risk

  4. Scintigraphic calf perfusion symmetry after exercise and prediction of cardiovascular events: One stone to kill two birds?

    Science.gov (United States)

    Tellier, Philippe; Lecouffe, Pascal; Zureik, Mahmoud

    2007-02-01

    BackgroundPeripheral arterial disease (PAD) is commonly associated with a high cardiovascular mortality and morbidity as a marker of plurifocal atherosclerosis. Whether exercise thallium perfusion muscular asymmetry in the legs associated with PAD has prognostic value is unknown. Such a hypothesis was evaluated in a prospective study which remains the gold standard in clinical research. Methods and resultsScintigraphic calf perfusion symmetry after exercise (SCPSE) was measured at the end of a maximal or symptom-limited treadmill exercise test in 358 patients with known or suspected coronary artery disease (CAD). During the follow-up period (mean 85.3±32.8 months), 93 cardiovascular events and deaths (incident cases) occurred. Among those incident cases, the percentage of subjects with higher SCPSE values (third tertile) was 45.2%, versus 29.1% in controls (lower tertiles) ( p=0.005). In stepwise multivariate analysis performed with the Cox proportional hazards model, previous CAD and SCPSE were the only significant independent predictors of prognosis. The multivariate relative risk of cardiovascular death or event in subjects with higher values of SCPSE was 1.94 (95% CI: 1.15-3.21; p<0.01). ConclusionsScintigraphic calf perfusion asymmetry after exercise was independently associated with incident cardiovascular events in high-risk subjects. This index, which is easily and quickly calculated, could be used for evaluation of cardiovascular risk.

  5. Multimodality image analysis work station

    International Nuclear Information System (INIS)

    Ratib, O.; Huang, H.K.

    1989-01-01

    The goal of this project is to design and implement a PACS (picture archiving and communication system) workstation for quantitative analysis of multimodality images. The Macintosh II personal computer was selected for its friendly user interface, its popularity among the academic and medical community, and its low cost. The Macintosh operates as a stand alone workstation where images are imported from a central PACS server through a standard Ethernet network and saved on a local magnetic or optical disk. A video digitizer board allows for direct acquisition of images from sonograms or from digitized cine angiograms. The authors have focused their project on the exploration of new means of communicating quantitative data and information through the use of an interactive and symbolic user interface. The software developed includes a variety of image analysis, algorithms for digitized angiograms, sonograms, scintigraphic images, MR images, and CT scans

  6. Scintigraphic scoring system for grading severity of gastro-esophageal reflux on 99mTc sulfur colloid gastro-esophageal reflux scintigraphy: a prospective study of 39 cases with pre and post treatment assessment

    International Nuclear Information System (INIS)

    Puranik, Ameya D.; Nair, Gopinathan; Bandyopadhyay, Abhijit; Shinto, Ajit; Zade, Anand; Aggarwal, Rajiv

    2013-01-01

    The study aimed at developing a scoring system for scintigraphic grading of gastro-esophageal reflux (GER), on gastro-esophageal reflux scintigraphy (GERS) and comparison of clinical and scintigraphic scores, pre- and post-treatment. A total of 39 cases with clinically symptomatic GER underwent 99m Tc sulfur colloid GERS; scores were assigned based on the clinical and scintigraphic parameters. Post domperidone GERS was performed after completion of treatment. Follow up GERS was performed and clinical and scintigraphic parameters were compared with baseline parameters. Paired t-test on pre and post domperidone treatment clinical scores showed that the decline in post-treatment scores was highly significant, with P value < 0.001. The scintigraphic scoring system had a sensitivity of 93.9% in assessing treatment response to domperidone, specificity of 83.3% i.e., 83.3% of children with no decline in scintigraphic scores show no clinical response to Domperidone. The scintigraphic scoring system had a positive predictive value of 96.9% and a negative predictive value of 71.4%. GERS with its quantitative parameters is a good investigation for assessing the severity of reflux and also for following children post-treatment. (author)

  7. The additional diagnostic value of a single-session combined scintigraphic and ultrasonographic examination in patients with thyroid and parathyroid diseases.

    Science.gov (United States)

    Gedik, G K; Bozkurt, F M; Ugur, O; Grassetto, G; Rubello, D

    2008-09-01

    ) to diagnose a diffuse hyperfunctioning thyroid gland, and to differentiate in multinodular goiters the hyper- from the hypo-functioning nodules. In the hyperparathyroid diseases group, scintigraphy was particular useful in making a differential diagnosis between a true parathyroid enlargement vs. a lymph node or a muscle or a vessel as depicted at USG, and in cases with deeply or ectopically-positioned parathyroid glands. Combined imaging approach. Combined interpretation provided additional benefit in 225 of 339 patients (64.4%). Overall, using the combined scintigraphic/USG single-day protocol, in the thyroid diseases group the therapeutic strategy (drug therapy vs radioiodine therapy vs surgery) was changed in 176/225 patients (78.2%, Pthyroid and parathyroid diseases, enrolled in a limited period of time, proved to significantly increase the global diagnostic accuracy and to change the therapeutic strategy in more than two third of patients with a thyroid disease and in more than one third of patients with a parathyroid disease.

  8. Causes of appearance of scintigraphic hot areas on thyroid scintigraphy analyzed with clinical features and comparative ultrasonographic findings

    Energy Technology Data Exchange (ETDEWEB)

    Iwata, Masahiro [Hikone Municipal Hospital, Shiga (Japan); Kasagi, Kanji [Takamatsu Red Cross Hospital, Kagawa (Japan); Hatabu, Hiroto [Univ. of Pennsylvania Medical Center, PA (United States); Misaki, Takashi; Iida, Yasuhiro; Fujita, Toru; Konishi, Junji [Kyoto Univ. (Japan). Graduate School of Medicine

    2002-06-01

    This study was done retrospectively to analyze the ultrasonographic (US) findings in thyroid scintigraphic hot areas (HA). Three-thousand, eight-hundred and thirty-nine consecutive patients who underwent {sup 99m}Tc-pertechnetate (n=3435) or {sup 123}I (n=457) scintigraphy were analyzed. HA were regarded as present when the tracer concentration was greater than the remaining thyroid tissue, or when hemilobar uptake was observed. High-resolution US examinations were performed with a real-time electronic linear scanner with a 7.5 or 10 MHz transducer. One hundred and four (2.7%) were found to be scintigraphic HA (n=120). US revealed a nodular lesion or well-demarcated thyroid tissue corresponding to the HA in 94 areas (78.4%, Category 1), an ill-defined region with different echogenicity in 13 areas (10.8%, Category 2), and no correlating lesion in 13 areas (10.8%, Category 3). These 104 patients included 43 with adenomatous goiter (59 areas), 33 with adenoma, 11 with Hashimoto's thyroiditis, 5 with primary thyroid cancer, 4 with euthyroid ophthalmic Graves' disease (EOG), 3 with hemilobar atrophy or hypogenesis, 2 with hemilobar agenesis, 2 with hypothyroidism with blocking-type TSH-receptor antibodies (TSHRAb), 1 with acute suppurative thyroiditis. Among the 59 adenomatous nodules and 33 adenomas, 51 (86.4%) and 32 (97.0%), respectively, belonged to Category 1. A solitary toxic nodule was significantly larger and occurs more often in older patients than in younger patients. On the other hand, all 17 patients with known autoimmune thyroid diseases including Hashimoto's thyroiditis, EOG and hypothyroidism with blocking TSHRAb belonged to Category 2 or 3. Possible underlying mechanisms are hyperfunctioning tumors or nodules, localized functioning thyroid tissue freed from autoimmune destruction, inflammation or tumor invasion, congenital abnormality, clusters of hyperactive follicular cells caused by long-term TSH and/or TSHRAb stimulation, asymmetry

  9. Causes of appearance of scintigraphic hot areas on thyroid scintigraphy analyzed with clinical features and comparative ultrasonographic findings.

    Science.gov (United States)

    Iwata, Masahiro; Kasagi, Kanji; Hatabu, Hiroto; Misaki, Takashi; Iida, Yasuhiro; Fujita, Toru; Konishi, Junji

    2002-06-01

    This study was done retrospectively to analyze the ultrasonographic (US) findings in thyroid scintigraphic hot areas (HA). Three-thousand, eight-hundred and thirty-nine consecutive patients who underwent 99mTc-pertechnetate (n = 3435) or 123I (n = 457) scintigraphy were analyzed. HA were regarded as present when the tracer concentration was greater than the remaining thyroid tissue, or when hemilobar uptake was observed. High-resolution US examinations were performed with a real-time electronic linear scanner with a 7.5 or 10 MHz transducer. One hundred and four (2.7%) were found to be scintigraphic HA (n = 120). US revealed a nodular lesion or well-demarcated thyroid tissue corresponding to the HA in 94 areas (78.4%, Category 1), an ill-defined region with different echogenicity in 13 areas (10.8%, Category 2), and no correlating lesion in 13 areas (10.8%, Category 3). These 104 patients included 43 with adenomatous goiter (59 areas), 33 with adenoma, 11 with Hashimoto's thyroiditis, 5 with primary thyroid cancer, 4 with euthyroid ophthalmic Graves' disease (EOG), 3 with hemilobar atrophy or hypogenesis, 2 with hemilobar agenesis, 2 with hypothyroidism with blocking-type TSH-receptor antibodies (TSHRAb), I with acute suppurative thyroiditis. Among the 59 adenomatous nodules and 33 adenomas, 51 (86.4%) and 32 (97.0%), respectively, belonged to Category 1. A solitary toxic nodule was significantly larger and occurs more often in older patients than in younger patients. On the other hand, all 17 patients with known autoimmune thyroid diseases including Hashimoto's thyroiditis, EOG and hypothyroidism with blocking TSHRAb belonged to Category 2 or 3. Possible underlying mechanisms are 1) hyperfunctioning tumors or nodules, 2) localized functioning thyroid tissue freed from autoimmune destruction, inflammation or tumor invasion, 3) congenital abnormality, 4) clusters of hyperactive follicular cells caused by long-term TSH and/or TSHRAb stimulation, 5) asymmetry, etc

  10. Causes of appearance of scintigraphic hot areas on thyroid scintigraphy analyzed with clinical features and comparative ultrasonographic findings

    International Nuclear Information System (INIS)

    Iwata, Masahiro; Kasagi, Kanji; Hatabu, Hiroto; Misaki, Takashi; Iida, Yasuhiro; Fujita, Toru; Konishi, Junji

    2002-01-01

    This study was done retrospectively to analyze the ultrasonographic (US) findings in thyroid scintigraphic hot areas (HA). Three-thousand, eight-hundred and thirty-nine consecutive patients who underwent 99m Tc-pertechnetate (n=3435) or 123 I (n=457) scintigraphy were analyzed. HA were regarded as present when the tracer concentration was greater than the remaining thyroid tissue, or when hemilobar uptake was observed. High-resolution US examinations were performed with a real-time electronic linear scanner with a 7.5 or 10 MHz transducer. One hundred and four (2.7%) were found to be scintigraphic HA (n=120). US revealed a nodular lesion or well-demarcated thyroid tissue corresponding to the HA in 94 areas (78.4%, Category 1), an ill-defined region with different echogenicity in 13 areas (10.8%, Category 2), and no correlating lesion in 13 areas (10.8%, Category 3). These 104 patients included 43 with adenomatous goiter (59 areas), 33 with adenoma, 11 with Hashimoto's thyroiditis, 5 with primary thyroid cancer, 4 with euthyroid ophthalmic Graves' disease (EOG), 3 with hemilobar atrophy or hypogenesis, 2 with hemilobar agenesis, 2 with hypothyroidism with blocking-type TSH-receptor antibodies (TSHRAb), 1 with acute suppurative thyroiditis. Among the 59 adenomatous nodules and 33 adenomas, 51 (86.4%) and 32 (97.0%), respectively, belonged to Category 1. A solitary toxic nodule was significantly larger and occurs more often in older patients than in younger patients. On the other hand, all 17 patients with known autoimmune thyroid diseases including Hashimoto's thyroiditis, EOG and hypothyroidism with blocking TSHRAb belonged to Category 2 or 3. Possible underlying mechanisms are hyperfunctioning tumors or nodules, localized functioning thyroid tissue freed from autoimmune destruction, inflammation or tumor invasion, congenital abnormality, clusters of hyperactive follicular cells caused by long-term TSH and/or TSHRAb stimulation, asymmetry, etc. Scintigraphic HA are

  11. Synthesis and preliminary scintigraphic evaluation of in vivo distribution of 11C-hydroxyurea/isohydroxyurea and 11C-cyanate

    International Nuclear Information System (INIS)

    Winstead, M.B.; Chern, C.-I.; Lin, T.-H.; Khentigan, A.; Lamb, J.F.; Winchell, H.S.

    1978-01-01

    H 11 CN, produced directly from proton bombardment of 99% N 2 -1% H 2 [ 14 N(p, α) 11 C], was oxidized by KMn0 4 to 11 C-cyanate which was added to hydroxylamine at -5 to 0 0 C to yield a mixture of hydroxyurea and isohydroxyurea. Scintigraphic evaluation of in vivo distribution in a dog following administration of K0 11 CN showed diffuse whole-body distribution, apparently including brain, with greater activity seen in regions of the heart, liver, and kidneys. Similar evaluation of a dog given 11 C-hydroxyurea/isohydroxyurea showed early localization of activity in the region of the heart which appeared to be due to activity in the myocardium. However, tissue activity measured in rats after administration of this material failed to demonstrate concentration in the myocardium. (author)

  12. Determining appropriate wind turbine setback distances: Perspectives from municipal planners in the Canadian provinces of Nova Scotia, Ontario, and Quebec

    International Nuclear Information System (INIS)

    Watson, Ian; Betts, Stephen; Rapaport, Eric

    2012-01-01

    This paper uses a series of interviews to investigate how municipal planners in three Canadian provinces (Nova Scotia, Quebec, and Ontario) influence setbacks that regulate appropriate locations for wind turbines. Setbacks are provisions in local land use policies that dictate required separation distances between wind turbines and other land uses. Results of the study indicate that planners are not using a consistent method to ascertain appropriate distances and are often constrained by a lack of experience, resources, and expertise. These findings have important implications for wind energy regulation. Setbacks are intended to reasonably protect the public from the impacts of wind turbines, while allowing for some development. Municipalities in Canada may be best placed to consider local impacts of wind power, but the challenges identified raise concerns about potential arbitrariness. Setbacks that are unjustifiably high can unnecessarily close off territory and limit the ability to reach renewable energy targets. Taking regulatory power away from municipalities, as has happened in Ontario, can facilitate achievement of provincial targets, but may also increase opposition to projects at the local level. - Highlights: ► Inconsistent methods used for establishing wind turbine setbacks. ► Most common method used is a review of other setback by-laws. ► Barriers to implementation of setbacks include knowledge, resources, and consensus. ► Recommend documentation of planning process in setting setbacks.

  13. Increased technetium uptake is not equivalent to muscle necrosis: scintigraphic, morphological and intramuscular pressure analyses of sore muscles after exercise

    Science.gov (United States)

    Crenshaw, A. G.; Friden, J.; Hargens, A. R.; Lang, G. H.; Thornell, L. E.

    1993-01-01

    A scintigraphic technique employing technetium pyrophosphate uptake was used to identify the area of skeletal muscle damage in the lower leg of four runners 24 h after an ultramarathon footrace (160 km). Most of the race had been run downhill which incorporated an extensive amount of eccentric work. Soreness was diffuse throughout the posterior region of the lower leg. In order to interpret what increased technetium uptake reflects and to express extreme endurance related damages, a biopsy was taken from the 3-D position of abnormal uptake. In addition, intramuscular pressures were determined in the deep posterior compartment. Scintigraphs revealed increased technetium pyrophosphate uptake in the medial portion of the gastrocnemius muscle. For 3698 fibres analysed, 33 fibres (1%) were necrotic, while a few other fibres were either atrophic or irregular shaped. A cluster of necrotic fibres occurred at the fascicular periphery for one subject and fibre type grouping occurred for another. Ultrastructural analysis revealed Z-line streaming near many capillaries and variously altered subsarcolemmal mitochondria including some with paracrystalline inclusions. The majority of the capillaries included thickened and irregular shaped endothelial cells. Intramuscular pressures of the deep posterior compartment were slightly elevated (12-15 mmHg) for three of the four subjects. Increased technetium uptake following extreme endurance running does not just reflect muscle necrosis but also subtle fibre abnormalities. Collectively, these pathological findings are attributed to relative ischaemia occurring during the race and during pre-race training, whereas, intramuscular pressure elevations associated with muscle soreness are attributed to mechanical stress caused by extensive eccentric work during the race.

  14. Imaging of acute myocardial infarction in pigs with Indium-111 monoclonal antimyosin scintigraphy and MRI

    International Nuclear Information System (INIS)

    Kate, C.I.; Kroonenburgh, M.J. van; Schipperheyn, J.J.; Doornbos, J.; Hoedemaeker, P.J.; Maes, A.; Nat, K.H. van der; Camps, J.A.; Huysmans, H.A.; Pauwels, E.K.

    1990-01-01

    Indium-111 antimyosin F(ab')2 was used in a series of scintigraphic studies on experimentally induced myocardial infarctions in pigs. Antimyosin distribution recorded by planar images of in vivo pigs and by single photon emission computed tomography (SPECT) of excised hearts delineated areas of myocardial necrosis if infarct volume exceeded 3.3 cm3. Scintigraphic images were compared with magnetic resonance images (MRI) obtained from excised hearts and with photographs of slices of the hearts. Infarct size and localization determined with antimyosin were compared. The MR images, with or without gadolinium-DTPA (Gd-DTPA), of the in vivo pigs were all false-negative; some myocardial wall thinning and high bloodpool signals were visible. Results show that both the antimyosin and the MR technique are specific methods for the visualization of induced myocardial necrosis in this animal model. However, the use of antimyosin is limited to a period ranging from 24 to 72 hours after infarction

  15. Clinical evaluation of the 99mTc-labelled myocardial imaging agent, hexakis (t-butylisonitrile)-technetium

    International Nuclear Information System (INIS)

    Liu Xiujie; Shi Rongfang; Wang Yanquen; Guo Xiuzhen; He Zuoxiang; Wang Xuebin; Liu Boli; Chinese Academy of Medical Sciences, Beijing. Div. of Nuclear Cardiology; Chinese Academy of Medical Sciences, Beijing. Cardiovascular Inst.; Beijing Normal Univ.

    1987-01-01

    99m Tc-TBI myocardial perfusion imaging has been studied in 7 normal subjects and 24 patients with coronary artery disease. Scintigraphic data revealed that 99m Tc-TBI myocardial perfusion imaging is more sensitive than ECG in detecting myocardial infarction. In comparing 99m Tc-TBI imaging with contrast angiography, its' sensitivity for the diagnosis of coronary artery disease was 91.7%. (orig.)

  16. Scintigraphic scoring system for grading severity of gastro-esophageal reflux on 99mTc sulfur colloid gastro-esophageal reflux scintigraphy: A prospective study of 39 cases with pre and post treatment assessment.

    Science.gov (United States)

    Puranik, Ameya D; Nair, Gopinathan; Aggarwal, Rajiv; Bandyopadhyay, Abhijit; Shinto, Ajit; Zade, Anand

    2013-04-01

    The study aimed at developing a scoring system for scintigraphic grading of gastro-esophageal reflux (GER), on gastro-esophageal reflux scintigraphy (GERS) and comparison of clinical and scintigraphic scores, pre- and post-treatment. A total of 39 cases with clinically symptomatic GER underwent 99mTc sulfur colloid GERS; scores were assigned based on the clinical and scintigraphic parameters. Post domperidone GERS was performed after completion of treatment. Follow up GERS was performed and clinical and scintigraphic parameters were compared with baseline parameters. Paired t-test on pre and post domperidone treatment clinical scores showed that the decline in post-treatment scores was highly significant, with P value reflux and also for following children post-treatment.

  17. External scintigraphy in monitoring the behavior of pharmaceutical formulations in vivo I: technique for acquiring high-resolution images of tablets

    International Nuclear Information System (INIS)

    Theodorakis, M.C.; Simpson, D.R.; Leung, D.M.; Devous, M. Sr.

    1983-01-01

    A new method for monitoring tablet disintegration in vivo was developed. In this method, the tablets were labeled with a short-lived radionuclide, technetium 99m, and monitored by a gamma camera. Several innovations were introduced with this method. First, computer reconstruction algorithms were used to enhance the scintigraphic images of the disintegrating tablet in vivo. Second, the use of a four-pinhole collimator to acquire multiple views of the tablet resulted in high count rates and reduced acquisition times of the scintigraphic images. Third, the magnification of the scintigraphic images achieved by pinhole collimation led to significant improvement in resolution. Fourth, the radioinuclide was incorporated into the granulation so that the whole mass of the tablet was uniformly labeled with high levels of activity. This technique allowed the continuous monitoring of the disintegration process of tablets in vivo in experimental animals. Multiple pinhole collimation and the labeling process permitted the acquisition of quality scintigraphic images of the labeled tablet every 30 sec. The resolution of the method was tested in vitro and in vivo

  18. New developments in techniques for information processing in radionuclide imaging

    International Nuclear Information System (INIS)

    Di Paola, R.; Todd-Pokropek, A.E.; CEA, 91 - Orsay

    1981-01-01

    Processing of scintigraphic data has passed through different stages in the past fifteen years. After an 'euphoric' era when large off-line computer facilities were used to process very low-quality rectilinear scan pictures, a much more critical period followed the introduction of on-line minicomputer systems to acquire, process and visualize scintillation camera data. A selection of some of the available techniques that could improve the extraction of information from scintigraphic examinations in routine is presented. Tomography has been excluded. As examples, the different techniques of (a) inhomogeneity correction of camera response and (b) respiratory motion corrections are used to show one evolutionary process in the use of computer systems. Filtering has been for a long time the major area of research in scintigraphic image processing. Only very simple (usually smoothing) filters are widely distributed. Little use of more 'powerful' filters in clinical data has been made, and very few serious evaluations have been published. Nevertheless, the number of installed minicomputer and microprocessor systems is increasing rapidly, but in general performing tasks other than filtering. The reasons for this (relative) failure are examined. Some 'new' techniques of image processing are presented. The compression of scintigraphic information is important because of the expected need in the near future for handling of large numbers of static pictures as in dynamic and tomographic studies. For dynamic information processing, the present methodology has been narrowed to those techniques that permit the entire 'data space' to be manipulated (as opposed to curve fitting after region of interest definition). 'Functional' imaging was the first step in this process. 'Factor analysis' could be the next. The results obtained by various research laboratories are reviewed. (author)

  19. Can bone metabolism markers be adopted as an alternative to scintigraphic imaging in monitoring bone metastases from breast cancer?

    International Nuclear Information System (INIS)

    Bombardieri, E.; Martinetti, A.; Castellani, M.R.; Seregni, E.; Miceli, R.; Mariani, L.

    1997-01-01

    Bone scintigraphy plays a major role in the diagnosis of bone metastases. The clinical utility of new biochemical markers of bone metabolism has recently been investigated in various bone diseases. This study evaluated the role of some bone metabolism markers in comparison with bone scan in the follow-up of breast cancer patients. We studied 149 patients with breast cancer, 33 (22%) of whom had bone metastases. IRMAs were used for the evaluation of blood levels of osteocalcin, bone alkaline phosphatase (BAP), the C-terminal propeptide of type I procollagen and the C-terminal cross-linked telopeptide of type I collagen (ICTP). Multivariate regression analysis showed that menopausal status (P=0.007) and metastatic bone lesions (P=0.001) affected bone marker levels. When considering post-menopausal women, the only subset in which bone metabolism marker behaviour could be reliably investigated, we found a high degree of overlap in marker distribution for scan-positive and scan-negative patients. Discrimination between scan-negative and scan-positive patients based on the above markers, taken singly or jointly, was assessed by means of logistic discriminant analysis. The best discrimination was achieved with BAP, closely followed by ICTP. BAP and ICTP together gave a slight improvement over the use of the two markers separately. However, even in this case the degree of discrimination was poor and its clinical utility was limited. In fact, to achieve a specificity of 95%, the sensitivity of the test was about 20%; conversely, with a sensitivity of 95%, the specificity was below 10%. In conclusion, based on our findings, we believe that blood levels of the investigated markers cannot replace bone scintigraphy in the follow-up of breast cancer patients for the early detection of bone metastases. (orig.)

  20. Dual myocardial scintigraphic imaging using 123I-BMIPP and 201Tl in patients with Duchenne's progressive muscular dystrophy

    International Nuclear Information System (INIS)

    Sasaki, Akira

    1996-01-01

    Dual single photon emission computed tomography (SPECT) was performed in 30 patients with Duchenne's muscular dystrophy (DMD) using 201 thallium (Tl) for myocardial perfusion 123 I-β-methyl-p-iodophenylpentadecanoic acid (BMIPP) for myocardial fatty acid metabolism scintigraphy. The left ventricle was divided into 9 regions, and accumulation of the radiotracers was assessed visually for each region to calculate defect score for each tracer. There was some degree of decrease in the myocardial accumulation of both tracers in all DMD patients. Reduced accumulation was most common at the apex (BMIPP, 70%; Tl, 63%), followed by the posterior wall, lateral wall, and anterior wall. It was less common on the apical side of the ventricular septum for both tracers (BMIPP, 3%; Tl, 17%). Accumulation of Tl was lower than BMIPP in 18/30 patients (60%) and higher in 9 (30%), while both tracers showed equal accumulation in 3 (10%). BMIPP showed higher accumulation than Tl in all regions but the septum. A significant negative correlation was found between the defect scores for both tracers and the left ventricular ejection fraction (LVEF) (r=-0.629 for Tl; r=-0.567 for BMIPP). The strongest negative correlation was that between the sum of the Tl and BMIPP defect scores and the LVEF (r=-0.681). Dual SPECT myocardial scintigraphy with Tl and BMIPP provided an accurate evaluation of the progression of cardiac lesions in DMD by detecting abnormalities of the myocardial metabolism of each substance thereby enabling the assessment of left ventricular function. (author)

  1. Imaging of bone spavin. A radiographic and scintigraphic study of degenerative joint disease in the distal tarsus in Icelandic horses

    International Nuclear Information System (INIS)

    Eksell, P.

    2000-01-01

    Radiography and scintigraphy are commonly used for the diagnosis of skeletal disorders in horses. Icelandic Horses have a high prevalence of degenerative joint disease of the distal tarsus, generally known as bone spavin (BS). The purpose of this study was to evaluate and develop the use of radiography and scintigraphy for the detection of BS in Icelandic Horses

  2. Real-Time Scintigraphic Assessment of Intravenous Radium-223 Administration for Quality Control

    Directory of Open Access Journals (Sweden)

    Chadwick L. Wright

    2015-01-01

    Full Text Available Radium-223 (223Ra dichloride is an approved intravenous radiotherapy for patients with osseous metastases from castration-resistant prostate cancer (CRPC. In addition to the therapeutic alpha radiation, there is additional 223Ra radiation generated which produces photons that can be imaged with conventional gamma cameras. No studies have evaluated real-time and quality imaging during intravenous 223Ra administration to verify systemic circulation and exclude 223Ra extravasation at the injection site. A retrospective review was performed for fifteen 223Ra administrations for CRPC patients which were imaged using a large field of view portable gamma camera (LFOVPGC for the purposes of quality control and patient safety. Dynamic imaging of the chest was performed before, during, and after the 223Ra administration to verify systemic circulation, per institutional clinical protocol. Before and after 223Ra administration, a static image was obtained of the intravenous access site. Dynamic imaging of the chest confirmed systemic administration early during the 1-minute injection period for all patients. There were no cases of focal 223Ra extravasation at the site of intravenous access. These results verify that systemic 223Ra administrations can be quantified with real-time imaging using an LFOVPGC. This simple approach can confirm and quantify systemic circulation of 223Ra early during injection and exclude focal extravasation for the purposes of quality control.

  3. When planners deal with change: Stories of Performativity in the politics of urban planning in two Scandinavian cities

    DEFF Research Database (Denmark)

    Lissandrello, Enza

    planning professionals become carriers of specific abilities that shape the possibilities of action and innovation in urban planning practice. It also argues that planning is performed by a plurality of actors, discourses, stages and politics but that in addition, urban planning proceeds by the acts...... the terrain of changing structural conditions altering current urban planning practice in two Scandinavian cities. Inspired by John Forester, their stories are here as lessons about what planning practitioners do in practice when facing challenges in their work. The aim is to explore an interpretation...... within a set of meanings and forms of legitimation. Across this analytic approach, some dimensions of transitions in urban planning include new institutional conditions and the actions of public planners, their performativity and their role in establishing innovative policy-making and planning practices...

  4. Idiopathic pulmonary fibrosis. A rare cause of scintigraphic ventilation-perfusion mismatch

    International Nuclear Information System (INIS)

    Pochis, W.T.; Krasnow, A.Z.; Collier, B.D.; Mewissen, M.W.; Almagro, U.A.; Hellman, R.S.; Isitman, A.T.

    1990-01-01

    A case of idiopathic pulmonary fibrosis with multiple areas of mismatch on ventilation-perfusion lung imaging in the absence of pulmonary embolism is presented. Idiopathic pulmonary fibrosis is one of the few nonembolic diseases producing a pulmonary ventilation-perfusion mismatch. In this condition, chest radiographs may not detect the full extent of disease, and xenon-133 ventilation imaging may be relatively insensitive to morbid changes in small airways. Thus, when examining patients with idiopathic pulmonary fibrosis, one should be aware that abnormal perfusion imaging patterns without matching ventilation abnormalities are not always due to embolism. In this setting, contrast pulmonary angiography is often needed for accurate differential diagnosis

  5. Idiopathic pulmonary fibrosis. A rare cause of scintigraphic ventilation-perfusion mismatch

    Energy Technology Data Exchange (ETDEWEB)

    Pochis, W.T.; Krasnow, A.Z.; Collier, B.D.; Mewissen, M.W.; Almagro, U.A.; Hellman, R.S.; Isitman, A.T. (Medical College of Wisconsin, Milwaukee (USA))

    1990-05-01

    A case of idiopathic pulmonary fibrosis with multiple areas of mismatch on ventilation-perfusion lung imaging in the absence of pulmonary embolism is presented. Idiopathic pulmonary fibrosis is one of the few nonembolic diseases producing a pulmonary ventilation-perfusion mismatch. In this condition, chest radiographs may not detect the full extent of disease, and xenon-133 ventilation imaging may be relatively insensitive to morbid changes in small airways. Thus, when examining patients with idiopathic pulmonary fibrosis, one should be aware that abnormal perfusion imaging patterns without matching ventilation abnormalities are not always due to embolism. In this setting, contrast pulmonary angiography is often needed for accurate differential diagnosis.

  6. Scintigraphic appearance of stress-induced trauma of the dorsal cortex of the third metacarpal bone in racing Thoroughbred horses: 121 cases (1978-1986)

    International Nuclear Information System (INIS)

    Koblik, P.D.; Hornof, W.J.; Seeherman, H.J.

    1988-01-01

    Review of 121 bone scintigrams obtained on racing Thoroughbred horses with clinical histories indicative of forelimb lameness revealed 3 scintigraphic patterns of stress-induced trauma to the dorsal cortex of the third metacarpal bone: (1) focal, intense uptake associated with recent stress fracture; (2) regional uptake of varying intensity or a mixed pattern of uptake associated with chronic stress fracture; and (3) diffuse, mild to moderate uptake associated with periostitis (bucked shins). The latter scintigraphic pattern appeared to be an exaggerated manifestation of the normal remodeling process evident in immature horses (2 to 3 years old). Scintigraphy was most helpful in identifying radiographically occult stress fractures, determining the extent of cortical involvement before surgical intervention in cases of chronic stress fractures, and monitoring the fracture healing process

  7. Coding paediatric outpatient data to provide health planners with information on children with chronic conditions and disabilities.

    Science.gov (United States)

    Craig, Elizabeth; Kerr, Neal; McDonald, Gabrielle

    2017-03-01

    In New Zealand, there is a paucity of information on children with chronic conditions and disabilities (CCD). One reason is that many are managed in hospital outpatients where diagnostic coding of health-care events does not occur. This study explores the feasibility of coding paediatric outpatient data to provide health planners with information on children with CCD. Thirty-seven clinicians from six District Health Boards (DHBs) trialled coding over 12 weeks. In five DHBs, the International Classification of Diseases and Related Health Problems, 10th Edition, Australian Modification (ICD-10-AM) and Systematised Nomenclature of Medicine Clinical Terms (SNOMED-CT) were trialled for 6 weeks each. In one DHB, ICD-10-AM was trialled for 12 weeks. A random sample (30%) of ICD-10-AM coded events were also coded by clinical coders. A mix of paper and electronic methods were used. In total 2,604 outpatient events were coded in ICD-10-AM and 693 in SNOMED-CT. Dual coding occurred for 770 (29.6%) ICD-10-AM events. Overall, 34% of ICD-10-AM and 40% of SNOMED-CT events were for developmental and behavioural disorders. Chronic medical conditions were also common. Clinicians were concerned about the workload impacts, particularly for paper-based methods. Coder's were concerned about clinician's adherence to coding guidelines and the poor quality of documentation in some notes. Coded outpatient data could provide planners with a rich source of information on children with CCD. However, coding is also resource intensive. Thus its costs need to be weighed against the costs of managing a much larger health budget using very limited information. © 2016 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).

  8. Planner's energy workbook: a manual for exploring relationships between land use and energy utilization

    Energy Technology Data Exchange (ETDEWEB)

    Carroll, T.O.; Nathans, R.; Palmedo, P.F.; Stern, R.

    1977-06-01

    It has been clear that the magnitude and character of a region's energy requirements are intimately related to the spatial configuration and mix of land use activities. To the degree to which they can shape the future configurations of residential, commercial, industrial, and transportation activities, local governments and their planners must give serious consideration to the energy implications of those configurations in the light of future social goals and requirements. This Planner's Energy Workbook describes a set of procedures that can be used to carry out community and regional energy analyses. The choice of land use activity parameters and their relation to energy use characteristics are associated with the normal planning concepts of land use density, type of residential development, commercial floorspace, industrial sales and employment, and shopping and work trip lengths. At the same time these energy related intensity coefficients are expressed in a form that permits the analysis of short-term conservation strategies such as the retrofit of insulation and the introduction of new technologies such as solar energy. An integrating framework is provided to construct total community or area energy consumption profiles and future needs; to examine compatibility between area requirements and the energy supply-distribution system serving the area; and to evaluate the implications for energy use of the physical configuration of urban, suburban and rural areas. Two cases illustrate the application of this Workbook. The Long Island area is representative of major suburban regions throughout the U.S. which have undergone major growth and development. A community redevelopment design in Tuscon, Arizona is typical of rapid and major land use development within the environs of an existing city.

  9. Scintigraphic and magnetic resonance studies in a patient with Gaucher's disease

    International Nuclear Information System (INIS)

    Zanzi, I.; Taylor, S.; Gould, E.; Allen, S.L.; Kroop, S.; Asnis, S.; Margouleff, D.

    1988-01-01

    In-111 chloride imaging was used in the evaluation of a patient with Type I Gaucher's disease before splenectomy for pancytopenia. This case is the first report of its use in this clinical setting. The image demonstrated the presence of adequate marrow reserve, thereby suggesting that the pancytopenia was due to hypersplenism rather than marrow replacement. Normalization of blood counts after splenectomy confirmed this interpretation. Eight months later, the patient had acute pain in the left knee. Bone imaging suggested a left lateral tibial plateau fracture that was not seen on plain radiographs or magnetic resonance imaging, but was confirmed by x-ray tomography. The significance and implications of these findings are discussed

  10. How planners' use and non-use of expert knowledge in land use and transport planning affect the goal achievement potential of plans? Experiences from three Scandinavian cities

    DEFF Research Database (Denmark)

    Tennøy, Aud; Hansson, Lisa; Lissandrello, Enza

    2016-01-01

    regions. Even if diffusion of research-based knowledge have been investigated, planners' use of expert knowledge when making plans, and the effects on the content of plans, have gained surprisingly little attention in planning research. Over the past few years, interesting discussions concerning...... achievement potential of plans. This knowledge is the main basis for many planners' knowing and acting, and fundamental for land use and transport planning being coordinated and for traffic-reducing measures being included in the plans. The knowledge is used for explaining cause-effect relations......, and as arguments for selecting traffic-reducing measures. All examined plans also include strategies reducing their goal achievement potentials. This happens through a mix of mechanisms. When competing objectives or ideas seemingly call for traffic-increasing measures, the planners do not use the expert knowledge...

  11. Challenges while Updating Planning Parameters of an ERP System and How a Simulation-Based Support System Can Support Material Planners

    Directory of Open Access Journals (Sweden)

    Ulrike Stumvoll

    2016-01-01

    Full Text Available In an Enterprise Resource Planning (ERP system, production planning is influenced by a variety of parameters. Previous investigations show that setting parameter values is highly relevant to a company’s target system. Parameter settings should be checked and adjusted, e.g., after a change in environmental factors, by material planners. In practice, updating the parameters is difficult due to several reasons. This paper presents a simulation-based decision support system, which helps material planners in all stages of decision-making processes. It will present the system prototype’s user interface and the results of applying the system to a case study.

  12. Modelo y desarrollo de W-planner: sistema multiagente on-line aplicado al turismo electrónico Modelo y desarrollo de W-planner: sistema multiagente on-line aplicado al turismo electrónico

    Directory of Open Access Journals (Sweden)

    Luis F. Castillo

    2005-04-01

    Full Text Available This paper introduces the “tourist problem” and presents an Multi-agent system based solution for it. A set of agents that uses a case-based reasoning system to identify actions and plans is capable of determining the most suitable itinerary with restrictions for a tourist. Wireless devises are used by the tourists to interact with the agent. Variational Calculus is used during the reasoning process to identify the set of posible problem solutions and Jacobi fields to find the most replanning-able solution. This analytical method facilitates the identification of a tourist itinerary in advance and is also capable of modifying the tourist route in execution time. To conclude, a case of typical use is shown, in which a tourist requests to the W-planner the most appropriate route that fits in well with the requirements.Este trabajo introduce el llamado ¿problema del turista¿ y presenta una solución basada en un sistema multiagente. Un grupo de agentes que usan un sistema para identificar acciones y planes es capaz de encontrar el itinerario más adecuado para un turista de acuerdo con ciertas restricciones. Los artefactos ¿sin hilos¿ se usan para que el turista interactúe con el agente. Se utilizan técnicas de ¿cálculo variacional¿ durante el proceso para identificar el conjunto de soluciones posibles del problema y técnicas de ¿campos de Jacobi¿ para encontrar la solución ¿más fácilmente replanificable¿. Este método analítico facilita la identificación de un itinerario turístico previamente y es capaz de modificar la ruta propuesta en tiempo de ejecución. Para finalizar se muestra el seguimiento de un caso de uso típico, en el cual un turista solicita al W-planner bajo ciertas condiciones la ruta más ajustada a sus requerimientos.

  13. Scintigraphic pattern of pneumothorax complicating Pneumocystis carinii pneumonia in patients with AIDS

    International Nuclear Information System (INIS)

    Finestone, H.; Goldfarb, C.R.; Ongseng, F.; Wasserman, I.; Garcia, H.

    1990-01-01

    Spontaneous pneumothorax is a serious though infrequently reported pulmonary complication of AIDS. An unsuspected lung collapse was discovered via gallium scintigraphy for the study of Pneumocystis carinii pneumonia. Neither the pneumonia nor the pneumothorax were apparent on the most recent chest roentgenogram. In evaluating gallium images during the work-up of AIDS patients with associated pulmonary pathology, the possible complication of lung collapse should be considered. If pneumothorax is suspected on gallium imaging, a chest roentgenogram in expiration must be obtained for prompt delineation of this serious, yet correctable, condition

  14. Marrow uptake index (MUI): A quantitative scintigraphic study of bone marrow in aplastic anaemia

    International Nuclear Information System (INIS)

    Padhy, A.K.; Garg, A.; Kochupillai, V.; Gopinath, P.G.; Basu, A.K.

    1987-01-01

    Aplastic anaemia affects the entire bone marrow. This prospective study was undertaken to develop and standardise a new nuclear medicine technique called 'dynamic bone marrow imaging'. Eleven patients and ten controls were studied. Serial images of the pelvis were obtained in frame mode following intravenous injection of 185-370 mBq of 99m Tc S. Colloid, and an index, called the bone marrow uptake index was calculated by taking into consideration the time activity curve obtained over the iliac crest. This was followed by static imaging of the entire bone marrow in all cases. It was possible to obtain excellent information regarding topographic distribution of bone marrow as well as detect early changes in bone marrow function following treatment. An attempt was also made to correlate bone marrow cellularity as obtained by bone marrow biopsy with results of dynamic bone marrow scintigraphy. On the basis of the encouraging results obtained in the present study, the authors feel that dynamic bone marrow imaging is an excellent technique for the objective evaluation of bone marrow in aplastic anaemia. 20 refs.; 4 figs.; 5 tabs

  15. Scintigraphic evaluation of the pharmacokinetics of a soluble polymeric drug carrier

    International Nuclear Information System (INIS)

    Pimm, M.V.; Perkins, A.C.; Hudecz, F.

    1992-01-01

    There is a growing interest in the use of macromolecular carriers for therapeutic agents. If these carriers can be labelled with an appropriate gamma-emitter, their biodistribution could be followed by scintigraphy. We have imaged the biodistribution of a synthetic branched polypeptide, based on a poly-L-lysine backbone (average molecular mass 45 kDa). The polymer was conjugated to diethylene triamine penta-acetic acid and labelled by chelation with indium-111. Mice were injected i.v. with labelled material and imaged with a gamma-camera with a pin-hole collimator. Images showed the majority of tracer remaining in the blood pool, but about 35% appeared in the urinary bladder within 1.5 h. When the 111 In-polymer was fractionated by gel filtration chromatography on S-300, the imaging showed that the early eluting material was retained, the intermediate showed some renal clearance, and the late was rapidly excreted. These findings show the value of gamma-scintigraphy for biodistribution studies with such polymeric drug carriers and its potential for clinical pharmacokinetic studies. (orig.)

  16. Indium-111 leukocyte scintigraphic detection of myocardial abscess formation in patients with endocarditis

    International Nuclear Information System (INIS)

    Cerqueira, M.D.; Jacobson, A.F.

    1989-01-01

    Myocardial abscess formation in patients with bacterial endocarditis in most clinical settings, especially in patients with prosthetic valves, is a primary indicator for surgical valve replacement. We report the detection of myocardial abscesses using 111 In leukocyte scintigraphy in three patients with prosthetic or native valve endocarditis and nondiagnostic echocardiograms. Leukocyte scintigraphy may allow identification of myocardial abscess formation earlier than other imaging modalities

  17. Nationwide standardisation and evaluation of scintigraphic gastric emptying: reference values and comparisons between subgroups in a multicentre trial

    International Nuclear Information System (INIS)

    Grybaeck, P.; Hermansson, G.; Lyrenaes, E.; Beckman, K.-W.; Jacobsson, H.; Hellstroem, P.M.

    2000-01-01

    By means of a standardised procedure, reference values for scintigraphic gastric emptying were established. The influence of gender, age, menstrual cycle, body mass index (BMI) and smoking habits was also evaluated. Eight centres recruited 20 healthy subjects each. The meal consisted of a technetium-99m labelled omelet (1300 kJ) and of 150 ml unlabelled soft drink. Geometric means of frontal and dorsal acquisitions were utilised in a linear fit model for determination of the linear emptying rate, and by using the intercepts of the regression line with the 90% and 50% levels, the lag phase and half-emptying time, respectively, were defined. All individuals showed an initial lag phase and subsequent linear emptying. Because of a longer lag phase and a slower linear emptying rate, premenopausal women had a slower gastric emptying than postmenopausal women and men of all ages. The gastric emptying rate increased with age in the women, mainly due to a shortened lag phase, while the emptying rate remained almost unchanged with age in the males. There were no significant differences in results between the centres. The menstrual cycle, BMI and smoking habits did not affect emptying. In conclusion, the fact that the results showed a slower gastric emptying rate in younger women compared with older women and men indicates that it is necessary to use separate reference values for fertile females. (orig.)

  18. Radiographic and scintigraphic evidence of focal pulmonary neoplasia in three cats with hyperthyroidism: diagnostic and therapeutic considerations

    International Nuclear Information System (INIS)

    Cook, S.M.; Daniel, G.B.; Walker, M.A.; Maddux, J.M.; Jenkins, C.C.; Klebanow, E.R.; Bouley, D.M.; Dean, D.F.; Petersen, M.G.

    1993-01-01

    Three cats were diagnosed as hyperthyroid based on clinical signs, historical findings, laboratory abnormalities, and basal serum thyroxine (T4) concentrations, and/or nuclear thyroid scans. Additionally, a presumptive diagnosis of thyroid carcinoma with pulmonary metastasis was made in each cat based on radiographic or scintigraphic evaluation. All three cats had solitary pulmonary nodules 1.5 to 2 cm in diameter on survey thoracic radiographs; one cat also had chylous pleural effusion and pulmonary lobar consolidation. Focal pulmonary accumulation of sodium pertechnetate (99mTcO4-) and/or radioiodine (131I) corresponding to radiographic lesions were seen in all cats. Two cats were treated with single ablative doses (1111 to 1480 MBq) of 131I; the remaining cat was euthanatized. One of the treated cats died 8 days later; the other cat was euthanatized 22 weeks following treatment. Histopathologic examination of tissue obtained at necropsy confirmed metastatic thyroid carcinoma in one cat and bronchogenic adenocarcinoma in two cats. Our findings indicate that increased radionuclide uptake in focal pulmonary lesions and cytologic evaluation of tissue obtained by fine-needle aspiration are not specific for thyroid tissue

  19. Nationwide standardisation and evaluation of scintigraphic gastric emptying: reference values and comparisons between subgroups in a multicentre trial

    Energy Technology Data Exchange (ETDEWEB)

    Grybaeck, P. [Department of Radiology, Karolinska Hospital, Stockholm (Sweden); Hermansson, G. [Department of Clinical Physiology, Oestra Hospital, Goeteborg (Sweden); Lyrenaes, E. [Department of Medicine, Blekinge Hospital, Karlskrona (Sweden); Beckman, K.-W. [Hospital Physics, Oerebro Hospital (Sweden); Jacobsson, H. [Department of Radiology, Karolinska Hospital, Stockholm (Sweden); Department of Nuclear Medicine, Karolinska Hospital, Stockholm (Sweden); Hellstroem, P.M. [Department of Gastroenterology and Hepatology, Karolinska Hospital, Stockholm (Sweden)

    2000-06-01

    By means of a standardised procedure, reference values for scintigraphic gastric emptying were established. The influence of gender, age, menstrual cycle, body mass index (BMI) and smoking habits was also evaluated. Eight centres recruited 20 healthy subjects each. The meal consisted of a technetium-99m labelled omelet (1300 kJ) and of 150 ml unlabelled soft drink. Geometric means of frontal and dorsal acquisitions were utilised in a linear fit model for determination of the linear emptying rate, and by using the intercepts of the regression line with the 90% and 50% levels, the lag phase and half-emptying time, respectively, were defined. All individuals showed an initial lag phase and subsequent linear emptying. Because of a longer lag phase and a slower linear emptying rate, premenopausal women had a slower gastric emptying than postmenopausal women and men of all ages. The gastric emptying rate increased with age in the women, mainly due to a shortened lag phase, while the emptying rate remained almost unchanged with age in the males. There were no significant differences in results between the centres. The menstrual cycle, BMI and smoking habits did not affect emptying. In conclusion, the fact that the results showed a slower gastric emptying rate in younger women compared with older women and men indicates that it is necessary to use separate reference values for fertile females. (orig.)

  20. Exercise-induced ST-segment depression and myocardial ischemia in patients with hypertrophic cardiomyopathy. Myocardial scintigraphic study

    International Nuclear Information System (INIS)

    Miyai, Nobuyuki; Kawasaki, Tatsuya; Taniguchi, Takuya; Kamitani, Tadaaki; Kawasaki, Shingo; Sugihara, Hiroki

    2005-01-01

    Patients with hypertrophic cardiomyopathy (HCM) sometimes develop myocardial ischemia during exercise in the absence of coronary lesions. The relationship between myocardial ischemia and ST-segment depression was investigated during exercise testing in patients with HCM. Regional hypoperfusion and/or transient left ventricular cavity dilation, a parameter of subendocardial hypoperfusion, were assessed on exercise 99 m Tc-tetrofosmin myocardial scintigraphy in 42 patients with non-obstructive HCM. The scintigraphic results were further correlated with the ST-segment responses to exercise. Regional hypoperfusion or transient left ventricular cavity dilation were observed in 19 (45%) or 16 (38%) patients with HCM, respectively. The incidence of ST-segment depression ≥0.1 mV during exercise testing was similar in HCM patients with regional hypoperfusion, with transient left ventricular cavity dilation, and without hypoperfusion (42%, 38%, 38%, p=0.95). Furthermore, exercise-induced ST-segment depression ≥0.1 mV occurred similarly irrespective of symptoms, exercise tolerance, the degree or the site of hypertrophy, or the presence or absence of resting ST-segment depression. ST-segment depression during exercise testing was common in patients with HCM, but seems to be an unreliable marker of myocardial ischemia as assessed by exercise scintigraphy. (author)

  1. Modification of the labelling autologous erythrocytes with Tc-99m to scintigraphic evaluation of deep vein system

    International Nuclear Information System (INIS)

    Quintero, C.M.; Freire, D.Y.

    1993-01-01

    The purpose of this was the modification of labelled autologous red blood cells in vivo/in vitro. Evaluation consisted in different combinations of Tc-99m radiopharmaceuticals as pyrophosphate (PYP) and stannous chloride (SnCl2), anticoagulants as heparin and acid-citrate-dextrose (ACD), and oxidant agents as hydrogen peroxide (H2O2) and sodium hypochlorite (NaClO); factorial block design was carried out to determinate which one brings a better yield of labelling, and more advantages of availability. Results showed that all tested combinations were above 90% labelled; variance analysis indicated significant difference between the two radiopharmaceuticals (P<0.05), being higher percent of labelling with PYP than SnCl2, and PYP-ACD-NaClO the best combination. It was demonstrated that the procedure is safe because hemocultives realized during the labelling process were all negative, evidencing no bacterial contamination. There were significant erythrocyte-shape modifications, too. Due to low costs and good availability of H2O2 as oxidant agent there were no statistic significant differences between the use of H2O2 or NaClO, the modification PYP-ACD-H2O2 will be used as scintigraphic test for deep vein thrombosis

  2. The impact of therapeutic delay time on acute scintigraphic lesion and ultimate scar formation in children with first febrile UTI.

    Science.gov (United States)

    Oh, Mi Mi; Kim, Jin Wook; Park, Min Gu; Kim, Je Jong; Yoo, Kee Hwan; Moon, Du Geon

    2012-03-01

    We assessed the role of therapeutic delay time (TDT) in acute renal cortical scintigraphic lesion (ASL) and ultimate scar formation (USF) in children with first febrile UTI and whether it is affected by the presence of vesico-ureteral reflux (VUR). 230 children, 90 girls and 140 boys with first febrile UTI were included. Radiologic (USG, DMSA, and VCUG), clinical (age, gender, peak fever, therapeutic delay time) and laboratory (CBC with differential count, ANC (absolute neutrophil count), BUN, Creatinine, urine analysis, gram stain, culture, CRP and ESR) variables were analysed. DMSA was performed within 5 days and after six months. VCUG was performed after acute phase of UTI. The differences in TDT according to the presence of ASL, USF and VUR were assessed. And the correlation between ASL or USF with the duration of TDT was assessed. Of 230 patients enrolled, 142 patients had refluxing UTI and 88 patients had non-refluxing UTI. TDT was the risk factor associated with ASL and USF along with presence of VUR. TDT was longer in ASL positive group compared with the ASL negative group. Also USF group showed longer TDT compared with those without USF in both refluxing UTI and non refluxing UTI. The TDT was significantly shorter in USF group with the presence of VUR. Positive linear association was noted between prevalence of ASL and USF and duration of TDT. In conclusion, the impact of UTI on formation of USF may be enhanced by the presence of VUR with shorter duration of TDT.

  3. Imaging

    International Nuclear Information System (INIS)

    Kellum, C.D.; Fisher, L.M.; Tegtmeyer, C.J.

    1987-01-01

    This paper examines the advantages of the use of excretory urography for diagnosis. According to the authors, excretory urography remains the basic radiologic examination of the urinary tract and is the foundation for the evaluation of suspected urologic disease. Despite development of the newer diagnostic modalities such as isotope scanning, ultrasonography, CT, and magnetic resonsance imaging (MRI), excretory urography has maintained a prominent role in ruorradiology. Some indications have been altered and will continue to change with the newer imaging modalities, but the initial evaluation of suspected urinary tract structural abnormalities; hematuria, pyuria, and calculus disease is best performed with excretory urography. The examination is relatively inexpensive and simple to perform, with few contraindictions. Excretory urography, when properly performed, can provide valuable information about the renal parenchyma, pelvicalyceal system, ureters, and urinary bladder

  4. Using OpenTripPlanner to determine lowest cost home-work-home trips as an input to UrbanSim

    CSIR Research Space (South Africa)

    Waldeck, L

    2014-09-01

    Full Text Available for the provision of infrastructure and social facilities. The model is currently based on two open source projects, UrbanSim and Open Trip Planner. The paper describes the modifications that had to be introduced to apply the software in the South African context...

  5. Assessing social vulnerability to climate change in human communities near public forests and grasslands: a framework for resource managers and planners

    Science.gov (United States)

    A. Paige Fischer; Travis Paveglio; Matthew Carroll; Daniel Murphy; Hannah Brenkert-Smith

    2013-01-01

    Public land management agencies have incorporated the concept of vulnerability into protocols for assessing and planning for climate change impacts on public forests and grasslands. However, resource managers and planners have little guidance for how to address the social aspects of vulnerability in these assessments and plans. Failure to assess social vulnerability to...

  6. The Use of land evaluation information by land use planners and decision-makers; a case study in Santa Catarina, Brazil

    NARCIS (Netherlands)

    Bacic, I.L.Z.; Rossiter, D.G.; Bregt, A.K.

    2003-01-01

    Land evaluation is the prediction of land performance over time under specific uses, to guide strategic land use decisions. Modern land evaluation has a 30 year history, yet the results have often been disappointing. Land users and planners have been reported to ignore land evaluations, perhaps

  7. Educating spatial planners for the age of co-creation : the need to risk community, science and practice involvement in planning programmes and curricula

    NARCIS (Netherlands)

    Rooij, R.M.; Frank, A.I.

    2016-01-01

    Planners are often billed as leaders and change agents of the (un)built environment. It is, however, important to recognize that they are in reality only one of many players in a sea of actors involved in shaping future developments and projects. Plans and interventions today are co-created and in

  8. Formacion de Formadores: Experiencias Institucionales en Planeamiento y Administracion de la Educacion. (The Formation of Educational Planners: Institutional Experiences in Planning and Administration for Education.

    Science.gov (United States)

    Senen Gonzalez, Silvia N. de

    Information collected from interviews with 15 ministers of education and 30 program directors and researchers at 18 universities in Venezuela, Costa Rica, Chile, Mexico, Colombia, Brazil, and Argentina is used to study academic programs which prepare persons to be educational planners and administrators. Section one describes background…

  9. Scintigraphic evidence for overdiagnosis of small PE on CT pulmonary angiography

    International Nuclear Information System (INIS)

    Lu, Yang

    2017-01-01

    A 68-year-old man with recent history of a fall presented with dyspnea on exertion, and underwent computed tomography pulmonary angiography (CTPA) for possible pulmonary embolism (PE). The CTPA was first read by the radiology resident as nondiagnostic for segmental PE. Subsequent planar perfusion (Q) images were normal; meanwhile, the attending radiologist revised the CTPA results as subsegmental PE in the left upper lobe. Further Q-SPECT images were obtained and fused with CTPA for clarification, which showed normal perfusion in the region of PE. The patient was monitored without anticoagulation treatment and remained uneventful for 12 months. This case illustrates that CTPA can lead to overdiagnosis and overtreatment of nonocclusive subsegmental PE

  10. Utility of thallium-201 and iodine-123 metaiodobenzylguanidine in the scintigraphic detection of neuroendocrine neoplasia

    International Nuclear Information System (INIS)

    Montravers, F.; Coutris, G.; Sarda, L.; Mensch, B.; Talbot, J.N.

    1993-01-01

    In order to determine whether the association of the two markers is able to improve the detection of neuroendocrine lesions, 137 sctinigraphic examinations using MIBG and thallium were performed in 101 patients referred for suspicion or follow-up of neuroendocrine tumours. Thallium chloride was first injected (1 MBq/kg), images being acquired about 20 min after injection; 123 I-MIBG (4 MBq/kg) was then injected and images acquired 5 and 24 h later. In patients with phaeochromocytoma or neuroblastoma, thallium scintigraphy appeared of little help since no tumoural site was discovered by thallium accumulation alone. In contrast, thallium examination seemed of interest in the detection of paraganglioma and MTC, the association of the two radiopharmaceuticals increasing the number of detected sites. (orig./MTG)

  11. Scintigraphic detection of carotid atherosclerosis with indium-111-labeled autologous platelets

    International Nuclear Information System (INIS)

    Davis, H.H.; Siegel, B.A.; Sherman, L.A.; Heaton, W.A.; Naidich, T.P.; Joist, J.R.; Welch, M.J.

    1980-01-01

    Using autologous platelets labeled with indium-111-oxine, we studied the localization of platelets on arterial lesions by radionuclide scintigraphy in 34 patients with suspected cerebrovascular disease. The imaging results were compared with the findings of contrast angiography in 23 patients, 16 of whom were receiving antiplatelet and/or anticoagulant drugs during the platelet imaging study. Angiography demonstrated atherosclerotic lesions at 33 sites in the extracranial arteries of 16 of these patients. There was accumulation of 111 In-platelets at 20 of these sites (61%) and at three other sites without definite angiographic abnormalities. Lesions with stenoses 111 In-labeled autologous platelets may be useful for evaluating the pathophysiologic characteristics of atherosclerotic lesions in patients with cerebrovascular disease

  12. Bilateral generalised synovial chondromatosis of the knee: Bone scintigraphic demonstration with radiologic correlation

    International Nuclear Information System (INIS)

    Elri, Tarik; Cabuk, Mehmet; Salihoglu, Yavuz Sami; Erdemir, Rabiye Uslu; Serifoglu, Ismail

    2016-01-01

    A 67-year-old woman with a history of bilateral progressive knee pain and swelling was referred for 99m Tc-methyl diphosphonate bone scintigraphy. Flow and blood pool images showed bilateral heterogeneous increased uptake and delayed phase revealed mass-looking lobulated heterogeneous increased activity in both of knees extending distal part of the femoral shaft, but no other pathologic uptake was found in rest of the body. A diagnosis of synovial chondromatosis was made when correlated with X-ray and computed tomography.(CT) images. This is a rare presentation of generalized synovial chondromatosis involving both knees which demonstrated on bone scintigraphy with X-ray and CT correlation

  13. Indium-111 leukocyte scintigraphic detection of myocardial abscess formation in patients with endocarditis

    Energy Technology Data Exchange (ETDEWEB)

    Cerqueira, M.D.; Jacobson, A.F.

    1989-05-01

    Myocardial abscess formation in patients with bacterial endocarditis in most clinical settings, especially in patients with prosthetic valves, is a primary indicator for surgical valve replacement. We report the detection of myocardial abscesses using /sup 111/In leukocyte scintigraphy in three patients with prosthetic or native valve endocarditis and nondiagnostic echocardiograms. Leukocyte scintigraphy may allow identification of myocardial abscess formation earlier than other imaging modalities.

  14. Characteristic focal hot spots of bone marrow scintigraphic finding in aplastic anemia

    International Nuclear Information System (INIS)

    Liu Yong

    1991-01-01

    The bone marrow scintigraphy with 99m Tc sulfur colloid has been performed in 168 patients with Aplastic anemia(AA) and 100 patients with others hematological disorders. Bone marrow imaging is a useful method to demonstrate the existence of active hematopoietic foci in living body. The features and clinical significance of these focal hot spots have been discussed. The bone marrow scintigraphy is proved to be helpful in diagnosis, therapy and assessing prognosis of A.A

  15. Scintigraphic assessment of salivary tolerance for the purpose of weaning tracheostomy patients

    International Nuclear Information System (INIS)

    Chew, J.; Conci, L.; Chew, C.

    2002-01-01

    Full text: The aim of this study was to visually assess the tolerance of salivary aspiration by tracheostomy patients being considered for tracheostomy decannulation. In 7 tracheostomy patients with the tracheostomy cuff deflated, 300MBq of 99mTc Hepatate was infused orally via an extension tube at 4ml/hr for 15mins. Dynamic images were acquired for 30 minutes, followed by static images in the anterior, right and left anterior oblique projections, and flood tank transmission image for better anatomical localisation. Delayed static views were done to demonstrate the effect of suction on any aspirated tracer. 6 Of the 7 subjects aspirated to the level of the trachea and main bronchi, 2 into the lung fields. Suction cleared the aspirate in 5, residual lung activity noted in 1 subject. Cuff deflation was tolerated, allowing tracheostomy removal in the 1 subject who did not aspirate and the 3 subjects who did. Of the other 3 with demonstrable aspiration, 2 tolerated a mini-trach, monitored by a follow-up scan, but died from other complications prior to decannulation, whilst the third is still tracheostomy dependent 4 of the 7 have since died. Scintigraphy provides a non invasive, quantitative, safe, and sensitive method of monitoring swallowing in incapacitated patients whose cooperation is limited. The scan information allows greater confidence in a less conservative approach to weaning of the tracheostomy. Copyright (2002) The Australian and New Zealand Society of Nuclear Medicine Inc

  16. Diagnosis of exercise-induced left bundle branch block at rest by scintigraphic phase analysis

    International Nuclear Information System (INIS)

    Schultz, D.A.; Wahl, R.L.; Juni, J.E.; Buda, A.J.; McMeekin, J.D.; Struble, L.R.; Tuscan, M.J.

    1986-01-01

    Accurate diagnosis of disease of the ventricular conducting system is essential for their appropriate therapy. Some conduction abnormalities, such as exercise-induced left bundle branch block (EX-LBBB), are not apparent on resting electrocardiograms. Phase analysis of rest and exercise radionuclide ventriculograms (RVG's) was used to compare four EX-LBBB patients with six normal controls. All patients had normal resting electrocardiograms, ejection fractions, and visually normal wall motion. First harmonic phase images were generated reflecting the timing of ventricular contraction. Dynamic phase displays were reviewed and graded in a blinded fashion by three independent experienced observers. Phase angle histograms of the right and left ventricle were determined for both resting and exercise images. The mean phase angle and standard deviation were also calculated for each ventricle. Visual grading of the resting phase images failed to show a significant difference between normal patients and patients with EX-LBBB. Quantitative analysis, however, revealed a significant difference in mean phase angle differences (LV-RV) in resting studies: 0.8 0 (+-1.9 0 SEM) in normal versus 9.3 0 (+-2.3 0 SEM) in EX-LBBB patients (P 0 in normals vs. 31.2 0 in EX-LBBB patients (P<0.001). Qualitative phase analysis of resting RVG's permits the diagnosis of cardiac conduction disease that is not apparent on the resting EKG and may result in better monitoring and treatment. (orig.)

  17. Clinical evaluation of left ventricular wall thickness by combined technique with gated planer 201Tl image and gated cardiac pool image

    International Nuclear Information System (INIS)

    Nakai, Kenji; Katsuragawa, Shigehiko; Takahashi, Tsuneo; Matsushita, Kazuo; Kawamura, Akiyoshi

    1983-01-01

    To evaluate the left ventricular (LV) wall thickness, combined technique with gated planer 201-Thallium image and gated cardiac pool image was applied to 6 patients with hypertrophic cardiomyopathy (HCM) and 4 patients with secondary hypertrophy due to hypertension (HHD) proven by electrocardiography and ultrasonic-echocardiography. Scintigraphic pattern of hypertrophy on reconstructed planer 201 Tl image showed diffuse or asymmetrical apical hypertrophy in HHD, asymmetrical septal hypertrophy in HCM. It was very interesting that abnormal perfusion was shown in 201 Tl image, despite symmetrical hypertrophy in echocardiography. This techniques provided useful information for evaluating the LV wall thickness and cardiac performance. (author)

  18. Clinical evaluation of left ventricular wall thickness by combined technique with gated planer /sup 201/Tl image and gated cardiac pool image

    Energy Technology Data Exchange (ETDEWEB)

    Nakai, Kenji; Katsuragawa, Shigehiko; Takahashi, Tsuneo; Matsushita, Kazuo; Kawamura, Akiyoshi

    1983-11-01

    To evaluate the left ventricular (LV) wall thickness, a combined technique with gated planer 201-thallium image and gated cardiac pool image was applied to 6 patients with hypertrophic cardiomyopathy (HCM) and 4 patients with secondary hypertrophy due to hypertension (HHD) proven by electrocardiography and ultrasonic-echocardiography. Scintigraphic pattern of hypertrophy on reconstructed planer /sup 201/Tl image showed diffuse or asymmetrical apical hypertrophy in HHD, asymmetrical septal hypertrophy in HCM. It was very interesting that abnormal perfusion was shown in /sup 201/Tl image, despite symmetrical hypertrophy in echocardiography. This techniques provided useful information for evaluating the LV wall thickness and cardiac performance.

  19. Super Network on the Prairie The Discursive Framing of Broadband Connectivity by Policy Planners and Rural Residents in Alberta, Canada

    Directory of Open Access Journals (Sweden)

    Maria Bakardjieva

    2010-06-01

    Full Text Available This paper focuses on the case of the SuperNet, an infrastructure project designed and sponsored by the provincial government of Alberta, Canada with the objective of providing broadband connectivity to public facilities, businesses and residences in rural communities. The data were collected through individual interviews, focus groups, and town hall meetings in the course of a collaborative research initiative (The SuperNet Research Alliance that investigated the social construction of the broadband network from multiple perspectives. The objective of the paper is to examine in parallel the discourses in which the concept of broadband connectivity acquired meaning and substance at the levels of 1 provincial government and industry policy planners and 2 the residents of the rural communities who were the intended beneficiaries of the SuperNet. Using actor-network theory as a departure point, this analysis takes stock of the framing devices employed in the two sets of discourses and of the distinctive worldviews that generated them. It looks for the meeting points and the disjunctions between the grand visions and the grounded projections underlying the positions taken by the two respective categories of actors. Differences in the interpretation and appropriation of broadband among rural Albertans themselves are discerned and related to social factors characterizing different situations within rural areas. Rural broadband connectivity thus emerges not so much as a one-dimensional access equalizer for rural people, but as a complex mediator of opportunity, participation and identity.

  20. Brazilian city planners, American city planning? New perspectives on urban planning in Rio de Janeiro, 1930-1945.

    Science.gov (United States)

    Rezende, Vera F

    2010-01-01

    This article analyses the connections between the ideas and principles of American city planning from 1920 with those articulated by Brazilian city planners in the 1930s and implemented by the administration of the City of Rio de Janeiro, then the capital of Brazil, notably during the period of the Estado Novo [The New State] from 1937 to 1945. In a period characterized by the centralization of political power and the concentration of decision-making in the hands of the president and the state, the City of Rio de Janeiro undertook a series of restructuring projects which utilized new forms of administration and organization. This article explores the links between urban planning in Brazil and the USA that were a notable feature of these projects. It examines particular requirements set down in city plans, city planning commissions and funding for urban activities, such as 'excess condemnation', by focusing upon articles and books written by four Brazilian engineers and proposals put forward by the American City Planning Institute, detailed in the proceedings of the National Conference on City Planning, in the periodical, City Planning and works by affiliated authors.

  1. Computer-aided surgical planner for a new bone deformity correction device using axis-angle representation.

    Science.gov (United States)

    Wu, Ying Ying; Plakseychuk, Anton; Shimada, Kenji

    2014-11-01

    Current external fixators for distraction osteogenesis (DO) are unable to correct all types of deformities in the lower limb and are difficult to use because of the lack of a pre-surgical planning system. We propose a DO system that consists of a surgical planner and a new, easy-to-setup unilateral fixator that not only corrects all lower limb deformity, but also generates the contralateral/predefined bone shape. Conventionally, bulky constructs with six or more joints (six degrees of freedom, 6DOF) are needed to correct a 3D deformity. By applying the axis-angle representation, we can achieve that with a compact construct with only two joints (2DOF). The proposed system makes use of computer-aided design software and computational methods to plan and simulate the planned procedure. Results of our stress analysis suggest that the stiffness of our proposed fixator is comparable to that of the Orthofix unilateral external fixator. We tested the surgical system on a model of an adult deformed tibia and the resulting bone trajectory deviates from the target bone trajectory by 1.8mm, which is below our defined threshold error of 2mm. We also extracted the transformation matrix that defines the deformity from the bone model and simulated the planned procedure. Copyright © 2014 IPEM. Published by Elsevier Ltd. All rights reserved.

  2. Building the capacity of policy-makers and planners to strengthen mental health systems in low- and middle-income countries: a systematic review

    Directory of Open Access Journals (Sweden)

    Roxanne Keynejad

    2016-10-01

    Full Text Available Abstract Background Little is known about the interventions required to build the capacity of mental health policy-makers and planners in low- and middle-income countries (LMICs. We conducted a systematic review with the primary aim of identifying and synthesizing the evidence base for building the capacity of policy-makers and planners to strengthen mental health systems in LMICs. Methods We searched MEDLINE, Embase, PsycINFO, Web of Knowledge, Web of Science, Scopus, CINAHL, LILACS, ScieELO, Google Scholar and Cochrane databases for studies reporting evidence, experience or evaluation of capacity-building of policy-makers, service planners or managers in mental health system strengthening in LMICs. Reports in English, Spanish, Portuguese, French or German were included. Additional papers were identified by hand-searching references and contacting experts and key informants. Database searches yielded 2922 abstracts and 28 additional papers were identified. Following screening, 409 full papers were reviewed, of which 14 fulfilled inclusion criteria for the review. Data were extracted from all included papers and synthesized into a narrative review. Results Only a small number of mental health system-related capacity-building interventions for policy-makers and planners in LMICs were described. Most models of capacity-building combined brief training with longer term mentorship, dialogue and/or the establishment of networks of support. However, rigorous research and evaluation methods were largely absent, with studies being of low quality, limiting the potential to separate mental health system strengthening outcomes from the effects of associated contextual factors. Conclusions This review demonstrates the need for partnership approaches to building the capacity of mental health policy-makers and planners in LMICs, assessed rigorously against pre-specified conceptual frameworks and hypotheses, utilising longitudinal evaluation and mixed

  3. A Scintigraphic Method for Quantitation of Lymphatic Function in Arm Lymphedema

    DEFF Research Database (Denmark)

    Hvidsten, Svend; Toyserkani, Navid M; Sørensen, Jens A

    2018-01-01

    ) measure of lymph fluid passing through the arm. METHODS AND RESULTS: Eleven patients, aged 34-68 years, with unilateral arm lymphedema following breast cancer treatment underwent simultaneous bilateral lymphoscintigraphy using intradermal injection of 99mTc-labeled human serum albumin (HSA). Imaging...... was performed at 30-45 minute intervals for 5 hours. Time activity curves from each injection site and each arm region were recorded. The input into the arm region was obtained as the (minus) time derivative of the injection site activity curve. In the proposed model the arm activity curve was considered...

  4. Scintigraphic visualization of myocardial infarcts in baboons using thallium-201 and technetium-99m pyrophosphate

    Energy Technology Data Exchange (ETDEWEB)

    Frick, M P; Ponto, R A; Pyle, R B; Yasmineh, W G; Loken, M K

    1978-01-01

    Four baboons with myocardial infarcts were evaluated using thallium-201 for myocardial imaging and /sup 99m/Tc pyrophosphate for infarct visualization. Scintiphotographic findings were compared with the size of myocardial infarcts calculated from measurements of the activity of MB isoenzymes of creatine kinase (CK-MB) in serum and in the myocardium at autopsy, as described by Sobel's method. Lack of thallium-201 accumulation was noted in left ventricular infarcts of 3 of the 4 baboons. These same areas localized /sup 99m/Tc pyrophosphate administered 24 to 30 h after infarction.

  5. PIPELINE TRANSPORTATION PLANNERS

    OpenAIRE

    FREDERICO DOS SANTOS LIPORACE

    2005-01-01

    Oleodutos têm um papel importante no transporte de petróleo e de seus derivados, pois são a maneira mais eficaz de transportar grandes volumes por longas distâncias. A motivação deste trabalho é que uma parte não negligenciável do preço final de um derivado de petróleo é influenciada pelo custo de transporte. Apesar disso, até onde sabemos, apenas alguns autores trabalharam neste problema específico, a maioria utilizando técnicas de programação inteira. Este tr...

  6. Airborne Tactical Crossload Planner

    Science.gov (United States)

    2017-12-01

    Regiment AGL above ground level AO area of operation APA American psychological association ASOP airborne standard operating procedure A/C aircraft...awarded a research contract to develop a tactical crossload tool. [C]omputer assisted Airborne Planning Application ( APA ) that provides a

  7. Imaging in tuberculosis of the skull and skull-base: case report

    International Nuclear Information System (INIS)

    Sencer, S.; Aydin, K.; Poyanli, A.; Minareci, O.; Sencer, A.; Hepguel, K.

    2003-01-01

    We report a 19-year-old girl, who presented with headache and tonic/clonic seizures. Imaging revealed a lytic parietal skull lesion with an adjacent epidural mass, masses in the right parietal lobe and a posterior skull-base mass. The diagnosis of tuberculosis was made after resection of the extradural mass and later verified with culture of Mycobacterium tuberculosis. The parenchymal and skull-base lesions resolved following antituberculous treatment. We present CT, scintigraphic, angiographic and MRI findings. (orig.)

  8. Lymphoscintigraphy and breast cancer: early and/or late image?

    International Nuclear Information System (INIS)

    Rousseau, C.; Campion, L.; Curtet, C.; Classe, J.M.; Dravet, F.; Fiche, M.; Sagan, C.; Chatal, J.F.; Resche, I.

    2001-01-01

    As the performance of early (H+1 to 4) and late (D1) lympho-scintigraphic images raises organisational problems in outpatient surgery for breast cancer, only early images are generally obtained. The present study evaluated whether two series of images are better than one and defined the advantages of both methodologies On hundred and eighteen patients with infiltrating breast carcinoma (T0, T1 and T2) were included in the study : 87 in group A (early and late images) and 31 in group B (only early images). All patients received two peritumoral injections of 99m Tc-sulphur colloid: 15-18 MBq (group A) and < 15 MBq (group B). During the operation, the patent blue technique was associated with radioactivity detection. The two groups were comparable for histological type and tumour size and localization. Successful localisation of sentinel-nodes on early lympho-scintigraphic images was significantly greater for group B. The sensitivity of early lymphoscintigraphy increased by 10% during the study. Sentinel node detection by the isotopic method alone or the two methods combined was comparable for both groups. In radioactivity detection, the count rate for sentinel nodes versus background (contralateral breast) was superposable for the two groups. During the learning phase, two series of images gave a definite advantage. Subsequently, lymphoscintigraphy performed at + 2 h was sufficient (the results for the two groups became superposable). (author)

  9. Techniques for combining isotopic images obtained at different energies

    International Nuclear Information System (INIS)

    Soussaline, F.; Di Paola, R.; Bazin, J.P.

    1976-01-01

    The technique described should be considered as a first step towards the classification of scintigraphic data where the energy is included. As in all such studies the interpretation of the resulting images is not necessarily at first evident, and certain experience needs to be established. This applies in particular to the images obtained with the higher factors. It is possible that the use of this technique may resolve, without requiring a priori information, the problem previously encountered using the other 'subtraction' type techniques [fr

  10. Supplementary value of functional imaging in forensic medicine.

    Science.gov (United States)

    Mirzaei, Siroos; Sonneck-Koenne, Charlotte; Bruecke, Thomas; Aryana, Kamran; Knoll, Peter; Zakavi, Rasoul

    2012-01-01

    The aim of this study is to evaluate the role of functional imaging for forensic purposes. We reviewed a few outpatient cases that were sent to our department for examination after traumatic events and one case with neuropsychic disturbances. Functional imaging showed signs of traumatic lesions in the skeletal system, of brain metabolism and of renal failure. Functional disturbances following traumatic events are in some cases more important than morphological abnormalities. Targeted scintigraphic examinations could be applied for visualisation of traumatic lesions or evaluation of functional disturbances caused by traumatic events. These examinations can be used as evidence in the courtroom.

  11. Precordial ST-segment depression during acute inferior myocardial infarction: clinical, scintigraphic and angiographic correlations

    International Nuclear Information System (INIS)

    Gibson, R.S.; Crampton, R.S.; Watson, D.D.; Taylor, G.J.; Carabello, B.A.; Holt, N.D.; Beller, G.A.

    1982-01-01

    The cause and associated pathophysiology of precordial ST-segment depression during acute inferior myocardial infarction (IMI) are controversial. To investigate this problem, electrocardiographic findings in 48 consecutive patients with acute IMI were prospectively compared with results of coronary angiography, submaximal exercise thallium-201 ( 201 Tl) scintigraphy and multigated blood pool imaging, all obtained 2 weeks after IMI, and with clinical follow-up at 3 months. Patients were classified according to the admission ECG obtained 3.3 +/- 3.1 hours after the onset of chest pain. Twenty-one patients (group A) had no or 201 Tl perfusion abnormalities (p 201 Tl defects or wall motion abnormalities in anterior or septal segments

  12. Skeletal scintigraphic appearance of an auto-transplanted osteoarticular plug: epiphyseal transplant

    International Nuclear Information System (INIS)

    Morrison, Stuart C.; O'Donnell, James; Makley, John T.

    2003-01-01

    Nuclear medicine bone scan is an essential diagnostic imaging tool both for the diagnosis and staging of bone tumors and in the follow-up of these patients. It is very important that we be able to discriminate between normal variants, changes related to altered physical stress, and recurrent disease in order to interpret the bone scan meaningfully. We wish to report the appearance of the isotope bone scan, technetium 99m-labeled methylene diphosphonate ( 99m Tc-MDP), associated with an auto-transplanted osteoarticular plug (epiphyseal transplant) performed following limb amputation. This reconstructive surgery can give a potentially misleading appearance on the nuclear medicine bone scan if one is unfamiliar with this surgical technique. (orig.)

  13. Skeletal scintigraphic appearance of an auto-transplanted osteoarticular plug: epiphyseal transplant

    Energy Technology Data Exchange (ETDEWEB)

    Morrison, Stuart C.; O' Donnell, James [University Hospitals Cleveland, Department of Radiology-Hb6, Department of Radiology-Hb6, 9500 Euclid Avenue, OH 44195, Cleveland (United States); Makley, John T. [University Hospitals Cleveland, Department of Orthopedic Surgery, The Cleveland Clinic Children' s Hospital, 9500 Euclid Avenue, OH 44195, Cleveland (United States)

    2003-07-01

    Nuclear medicine bone scan is an essential diagnostic imaging tool both for the diagnosis and staging of bone tumors and in the follow-up of these patients. It is very important that we be able to discriminate between normal variants, changes related to altered physical stress, and recurrent disease in order to interpret the bone scan meaningfully. We wish to report the appearance of the isotope bone scan, technetium 99m-labeled methylene diphosphonate ({sup 99m}Tc-MDP), associated with an auto-transplanted osteoarticular plug (epiphyseal transplant) performed following limb amputation. This reconstructive surgery can give a potentially misleading appearance on the nuclear medicine bone scan if one is unfamiliar with this surgical technique. (orig.)

  14. Scintigraphic diagnosis and computed tomographic localization of an accessory spleen following relapse of chronic immune thrombocytopaenia

    International Nuclear Information System (INIS)

    Cardaci, G.T.; Blake, M.P.

    1992-01-01

    Chronic immune thrombocytopaenia is an immunologically mediated disorder resulting in disordered platelet kinetics and potentially life-threatening disease. Failure of medical therapy is an indication for splenectomy, and responses are seen in 80% of patients following this procedure. An important cause of relapse following splenectomy is the presence of an accessory spleen. A patient with Hodgkin's Disease developed chronic immune thrombocytopaenia despite previous splenectomy. A remission was induced with immunosuppressive therapy, but he later relapsed. An accessory spleen was detected using 99 m Tc denatured red blood cells and localized using computed tomography. Resection of the accessory spleen resulted in clinical remission. As accessory spleens are often small in size, combined modality imaging is recommended in the evaluation of this disorder. 15 refs., 2 figs

  15. A simple method for determining split renal function from dynamic {sup 99m}Tc-MAG3 scintigraphic data

    Energy Technology Data Exchange (ETDEWEB)

    Wesolowski, Michal J.; Watson, Gage; Wanasundara, Surajith N.; Babyn, Paul [University of Saskatchewan, Department of Medical Imaging, Saskatoon, SK (Canada); Conrad, Gary R. [University of Kentucky College of Medicine, Department of Radiology, Lexington, KY (United States); Samal, Martin [Charles University Prague and the General University Hospital in Prague, Department of Nuclear Medicine, First Faculty of Medicine, Praha 2 (Czech Republic); Wesolowski, Carl A. [University of Saskatchewan, Department of Medical Imaging, Saskatoon, SK (Canada); Memorial University of Newfoundland, Department of Radiology, St. John' s, NL (Canada)

    2016-03-15

    Commonly used methods for determining split renal function (SRF) from dynamic scintigraphic data require extrarenal background subtraction and additional correction for intrarenal vascular activity. The use of these additional regions of interest (ROIs) can produce inaccurate results and be challenging, e.g. if the heart is out of the camera field of view. The purpose of this study was to evaluate a new method for determining SRF called the blood pool compensation (BPC) technique, which is simple to implement, does not require extrarenal background correction and intrinsically corrects for intrarenal vascular activity. In the BPC method SRF is derived from a parametric plot of the curves generated by one blood-pool and two renal ROIs. Data from 107 patients who underwent {sup 99m}Tc-MAG3 scintigraphy were used to determine SRF values. Values calculated using the BPC method were compared to those obtained with the integral (IN) and Patlak-Rutland (PR) techniques using Bland-Altman plotting and Passing-Bablok regression. The interobserver variability of the BPC technique was also assessed for two observers. The SRF values obtained with the BPC method did not differ significantly from those obtained with the PR method and showed no consistent bias, while SRF values obtained with the IN method showed significant differences with some bias in comparison to those obtained with either the PR or BPC method. No significant interobserver variability was found between two observers calculating SRF using the BPC method. The BPC method requires only three ROIs to produce reliable estimates of SRF, was simple to implement, and in this study yielded statistically equivalent results to the PR method with appreciable interobserver agreement. As such, it adds a new reliable method for quality control of monitoring relative kidney function. (orig.)

  16. Comparison of Duke ergo-metric score and of the classification based on scintigraphic data in the stratification of coronaries

    International Nuclear Information System (INIS)

    Ouhayoun, E.; Coca, F.J.; Payoux, P.; Tafani, J.A.M.; Esquerre, J.P.

    1997-01-01

    Stratification of risk (sudden death and infarction) remains a major problem of the way the coronaries are cared. Since 1987, a score based on the test-to-effort data was proposed by Mark and coll. of 'Duke University' team. They tried to demonstrate that this score provides a reliable classification of patients. We have compared the results obtained by using this score with those issued from the simultaneous analysis of the left ventricle (LV) function and LV perfusion. A hundred patients afflicted with coronaries (stenoses > 50%) benefited by a coupled study of the LV function and perfusion at rest and under effort made by means of MIBI scintigraphy. The effort test allowed calculating the 'Duke' score by means of a formula in terms of the angor index defined as follows: 0 for absence, 1 for angor and 2 for angor motivating cessation. According to Duke score three classes can be defined: patients of low risk, score ≥ 5; patients of intermediate risk, score in between 5 and -10; patients of high risk, score ≤ -10. Ejection fraction at effort acme was measured in every patient as well as the extension of perfusion defect, evaluated semi-quantitatively at effort and rest on the basis of bull's eye. Three groups of patients were created according to the results of perfusion+function couple): (A)- normal perfusion and function, the case of good prognostication; (B)- patients slightly afflicted (FEV effort > 50% and in-effort defect extension effort 50%). The last criteria were proved by several studies as bad prognostication. A table presents the risks according the Duke score for the three classes. One can observe that one third of the patients severely afflicted by confirmed ischemia are classified in the low-risk class. Besides, the majority of patients are ranked with intermediary risk, independently of scintigraphic results. In conclusion, these results concerning the stratification of coronaries show the superiority of the criteria based on scintigraphy over

  17. Scintigraphic evaluation of soft tissue tumors with technetium(V)-99m dimercaptosuccinic acid, a new tumor seeking radiopharmaceutical

    International Nuclear Information System (INIS)

    Ohta, H.; Yoshizumi, M.; Endo, K.; Torizuka, K.; Yokoyama, A.; Yamamoto, K.

    1984-01-01

    Recently, a very promising tumor seeking agent, a Tc(V)-99m dimercaptosuccinic acid (Tc(V)-DMS), which was labelled under optimal pH 8 and very low SnCl/sub 2/ concentrations, has been developed. An equilibrium between a stable form and a dissociated form of anion TcO/sub 4//sup 3-/, structural similarity to PO/sub 4//sup 3-/, postulated for tumor uptake. And the authors have previously reported that Tc(V)-DMS scintigram would be useful in the diagnosis of medullary thyroid carcinoma. In an attempt to widen its applicability, the scintigraphic examinations of soft tissue tumors with Tc(V)-DMS and comparative study with Ga-67 citrate were performed in 58 patients. Scintigrams were made 60-120 min after i.v. administration of 10 mCi Tc(V)-DMS using a conventional gamma camera. Tc(V)-DMS was found to have superior sensitivity of 90% for malignant tumors (including aggressive fibromatosis) to that with Ga-67 citrate of 56%, but inferior specificity of 71% to that with Ga-67 citrate of 80%. And the accuracy of the scan in soft tissue tumors with Tc(V)-DMS and Ga-67 citrate was 78% and 71%, respectively. Although the accumulation of Tc(V)-DMS has been detected in some benign soft tissue tumors and the exact mechanism of Tc(V)-DMS accumulation remains to be elucidated, these data indicated that Tc(V)-DMS scintigraphy would be of great use in the detection of extension or location of malignant soft tissue tumors

  18. Whole-body and pinhole bone scintigraphic manifestations of Reiter`s syndrome: distribution patterns and early and characteristic signs

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Sung-Hoon; Chung, Soo-Kyo; Park, Young-Ha; Lee, Sung-Yong; Sohn, Hyung-Sun [Department of Nuclear Medicine, Catholic University Hospitals, Seoul (Korea, Republic of); Bahk, Yong-Whee [Department of Radiology, Samsung Cheil Hospital, Sungkyunkwan University College of Medicine, Seoul (Korea, Republic of)

    1999-02-01

    The characteristic whole-body and pinhole scintigraphic manifestations of osteo-enthesopathy and arthropathy in Reiter`s syndrome (RS) are described, with an emphasis on early diagnosis. We analysed 59 sets of whole-body and pinhole bone scintigrams of 59 patients with RS. The population comprised 47 men and 12 women with an age range from 15 to 53 years (mean=29.4). Bone scintigraphy was carried out 2-2.5 h after intravenous injection of technetium-99m hydroxydiphosphonate using a single-head gamma camera (Siemens Orbiter Model 6601) with a low-energy high-resolution and a 4-mm pinhole collimator for whole-body and pinhole scintigraphy, respectively. In total 262 lesions of osteo-enthesopathy and arthritis were detected on 59 whole-body scintigrams, an incidence of 4.4 lesions per patient. As anticipated, the lesional distribution was asymmetrical: 68% were in the lower limb skeleton and 32% in the axial and upper limb skeleton. Pinhole bone scintigraphy, applied selectively to one region of interest in each case, enabled us to accurately diagnose arthritis and osteo-enthesopathy. It was noteworthy that osteo-enthesopathy, alone or in combination with arthritis, occurred in 78.9%, and had a strong predilection for the foot bones, especially the calcaneus (25.6%). Pinhole scintigraphy detected enthesopathy in the absence of radiographic alteration in 14.1% of cases and portrayed characteristic signs of RS in 6.9%. Whole-body bone scintigraphy augmented with pinhole scintigraphy was found to be useful in order to panoramically display the systemic involvement pattern, to assess the characteristic bone and articular alterations and to detect early signs of RS. (orig.) With 10 figs., 3 tabs., 19 refs.

  19. Detection of gastroesophageal reflux in survivors of congenital diaphragmatic hernia: A radionuclide scintigraphic study in 26 children

    International Nuclear Information System (INIS)

    Thomas, E.J.; Bharathi Dasan, J.; Chandrasekhar, N.; Tripathi, M.; Kumar, R.; Kumar, A.; Malhotra, A.; Gupta, D.K.; Mitra, D.K.

    2002-01-01

    Introduction: Anatomical and functional esophageal abnormalities in survivors with CDH are well known. Gastro-esophageal Reflux (GER) is a common cause of long-term morbidity in survivors of congenital diaphragmatic hernia. The incidence of GER in these patients varies from 20-70% using various modalities. Aims: The present retrospective analysis was undertaken to find out the incidence of GER detected by radionuclide scintigraphy in survivors of congenital diaphragmatic hernia. Materials and Methods: Radionuclide scintigraphy for GER detection were performed in 26 survivors of congenital diaphragmatic hernia (17 male and 9 female) with a mean age of 19 months; age range 10 days to 56 months. Seven of the children had symptoms suggestive of GER. Of these 7, 3 had recurrent respiratory tract infection, 2 had regurgitation, 1 had vomiting and 1 had epigastric pain. The remaining 19 children were referred as part of routine follow up. All the children underwent radionuclide scintigraphy with 100-200 micro curie (3.7 -7.4MBq) of Tc99m-Sulphur Colloid. Results: The radionuclide scintigraphy detected GER in 11 out of 26(42.3%) children. Among the 7 symptomatic children, 4 (57%) had positive scintigraphic studies for reflux. Of these 4, 3(75%) had proximal reflux and 1 had distal reflux. Of the 19 asymptomatic patients, 7 (37%) were positive for GER on scintigraphy. Of these 7, 4 (57%) had proximal reflux and 3 (43%) had distal reflux. Conclusions: There is high incidence of GER in survivors of congenital diaphragmatic hernia irrespective of the presence or absence of symptoms suggestive of GER. Scintiscanning being a simple, noninvasive test can be used for initial evaluation of survivors of CDH for GER

  20. Evaluation of myocardial involvement in Duchenne progressive muscular dystrophy with thallium-201 myocardial perfusion imaging

    Energy Technology Data Exchange (ETDEWEB)

    Kawai, Naoki; Yamamoto, Shuhei; Okada, Mitsuhiro (Nagoya Univ. (Japan). Faculty of Medicine)

    1983-12-01

    Myocardial involvement in progressive muscular dystrophy of the Duchenne type was evaluated in 19 patients using thallium-201 myocardial perfusion imaging. The qualitative analysis was performed in anterior, 3 left anterior oblique and left lateral projection images by three experienced physicians. Distinct perfusion defects were shown in 13 patients, especially in LV posterolateral or posterior walls (11 patients). There was no significant relationship between the presence of perfusion defects and the skeletal muscle changes or thoracic deformities assessed by transmission computed tomography. Slightly increased thallium-201 activity in RV free wall and lungs was shown in nine and one patient, respectively. The extensive perfusion defects were shown in 2 patients who died of congestive heart failure 1 to 2 years after the scintigraphic study. The myocardial scintigraphic changes were considered to be minimal in 7 of 9 patients who underwent two serial scintigraphic studies in 2 to 3 years. It was concluded that the thallium myocardial perfusion imaging was a useful clinical technique to evaluate the cardiomyopathy in Duchenne progressive muscular dystrophy.

  1. Evaluation of myocardial involvement in Duchenne progressive muscular dystrophy with thallium-201 myocardial perfusion imaging

    International Nuclear Information System (INIS)

    Kawai, Naoki; Yamamoto, Shuhei; Okada, Mitsuhiro

    1983-01-01

    Myocardial involvement in progressive muscular dystrophy of the Duchenne type was evaluated in 19 patients using thallium-201 myocardial perfusion imaging. The qualitative analysis was performed in anterior, 3 left anterior oblique and left lateral projection images by three experienced physicians. Distinct perfusion defects were shown in 13 patients, especially in LV posterolateral or posterior walls (11 patients). There was no significant relationship between the presence of perfusion defects and the skeletal muscle changes or thoracic deformities assessed by transmission computed tomography. Slightly increased thallium-201 activity in RV free wall and lungs was shown in nine and one patient, respectively. The extensive perfusion defects were shown in 2 patients who died of congestive heart failure 1 to 2 years after the scintigraphic study. The myocardial scintigraphic changes were considered to be minimal in 7 of 9 patients who underwent two serial scintigraphic studies in 2 to 3 years. It was concluded that the thallium myocardial perfusion imaging was a useful clinical technique to evaluate the cardiomyopathy in Duchenne progressive muscular dystrophy. (author)

  2. The skeletal changes of progressive systemic scleroderma (PSS), of exclusive Raynaud phenomenon and of circumscript scleroderma in a gamma camera scintigraph

    International Nuclear Information System (INIS)

    Ulbrich, T.

    1987-01-01

    The bases of this study are the skeletal scintigraphs of altogether 34 patients with the three forms of scleroderma mentioned in the title. The PSS shows a polytropic, symmetric distribution pattern, the exclusive Raynaud's phenomenon shows a basic skeleton which is unchanged in contrast to circumscript scleroderma, with which also the larger joints are relatively more frequently attacked than the little ones. As a result of high sensitivity skeletal scintiscanning makes possible an early recognition of osseous changes and is there with superior to X-radiology and should then see an increased use for the clarification of the diagnosis of arthropathy in scleroderma. (TRV) [de

  3. Is it possible for knowledge-based planning to improve intensity modulated radiation therapy plan quality for planners with different planning experiences in left-sided breast cancer patients?

    Science.gov (United States)

    Wang, Juanqi; Hu, Weigang; Yang, Zhaozhi; Chen, Xiaohui; Wu, Zhiqiang; Yu, Xiaoli; Guo, Xiaomao; Lu, Saiquan; Li, Kaixuan; Yu, Gongyi

    2017-05-22

    Knowledge-based planning (KBP) is a promising technique that can improve plan quality and increase planning efficiency. However, no attempts have been made to extend the domain of KBP for planners with different planning experiences so far. The purpose of this study was to quantify the potential gains for planners with different planning experiences after implementing KBP in intensity modulated radiation therapy (IMRT) plans for left-sided breast cancer patients. The model libraries were populated with 80 expert clinical plans from treated patients who previously received left-sided breast-conserving surgery and IMRT with simultaneously integrated boost. The libraries were created on the RapidPlan TM . 6 planners with different planning experiences (2 beginner planners, 2 junior planners and 2 senior planners) generated manual and KBP optimized plans for additional 10 patients, similar to those included in the model libraries. The plan qualities were compared between manual and KBP plans. All plans were capable of achieving the prescription requirement. There were almost no statistically significant differences in terms of the planning target volume (PTV) coverage and dose conformality. It was demonstrated that the doses for most of organs-at-risk (OARs) were on average lower or equal in KBP plans compared to manual plans except for the senior planners, where the very small differences were not statistically significant. KBP data showed a systematic trend to have superior dose sparing at most parameters for the heart and ipsilateral lung. The observed decrease in the doses to these OARs could be achieved, particularly for the beginner and junior planners. Many differences were statistically significant. It is feasible to generate acceptable IMRT plans after implementing KBP for left-sided breast cancer. KBP helps to effectively improve the quality of IMRT plans against the benchmark of manual plans for less experienced planners without any manual intervention. KBP

  4. Lymph-scintigraphic identification of sentinel lymph nodes in breast carcinoma and malignant melanoma patients

    International Nuclear Information System (INIS)

    Sergieva, S; Bajchev, G.; Aleksandrova, E.

    1999-01-01

    It is the purpose of the study to assay the possibilities of lymphoscintigraphy (LS) in evaluating local lymphatic drainage and sentinel lymph nodes (SLNs) location in patients presenting breast carcinoma and malignant melanoma. Twenty-nine women with breast carcinoma (TI-IIa clinical stage, age range 31 to 74 y) and 7 patients with malignant melanoma (Clark III-V) are scanned in the period 1997 through 1998. 99m Tc-sulphur colloid (Solco Lymphoscint, SORIN) with mean size of particles 50 nm is used. Planar images are obtained at 20 and 120-180 min after sc injection in the region of primary tumor, at mean radioactivity 20 MBq per injection site in a volume 0.2-0.3 ml. In the breast cancer patients Patent Blue V or Mitoxantrone is injected around the tumor twice - 20 and 3 to 1/2 hours prior to surgery. In malignant melanoma patients immunoscintigraphy using 740 MBq 99m Tc-anti-melanoma monoclonal antibodies (Technemab-K-1) is carried out before lymph node dissection. SLNs are visualized in 25 patients (86.2%) with breast cancer. In 21 (72%) patients to 4 SLNs are scanned in level I of the local axillary region, in 4 cases (14%) - in the region of axillary level II, in one female patient (3%) - at axillary level III, and in 3 patients (10%) i psilateral internal mammary lymph nodes are scanned. Two patients are suspected for the so-called s kip t ype of tumor lymphatic dissemination. In 4 patients no SLN images are visible. In breast carcinoma patients SLN are additionally stained blue and following intraoperative revision, evidence of metastatic involvement is established in 12 instances (41.3%). In 3 patients with melanoma in the abdomen and back SLNs are located in the region of inguinal and axillary lymph node groups, while in 3 patients presenting lesions to the surface of extremities only local lymph nodes draining the melanoma are visualized. Immunoscintigraphy shows enhanced uptake in the region of SLNs in 3 cases with the metastatic changes in them

  5. Scintigraphic quantitation of gastrointestinal motor activity and transport: Oesophagus and stomach

    International Nuclear Information System (INIS)

    Stacher, G.; Bergmann, H.

    1992-01-01

    For the recognition and characterisation of oesophageal motor disorders, manometry represents the most reliable tool but yields no information on bolus transport. The transport can be quantitated by radionuclide techniques. The patient is positioned supine beneath a gamma-camera and instructed to swallow a radiolabelled bolus in a single gulp. Using a marker over the cricoid and the activity in the stomach as landmarks, regions of interest are drawn representing the upper, middle and lower third of the oesophagus and the gastric fundus. Activity-time curves enable one to recognise the clearance patterns in these regions. In combination, manometric and radionuclide transit studies recognise a higher number of motor disorders than either procedure alone. Radionuclide methods also are the most reliable and sensitive to quantitate gastric emptying. Procedure, meal size and composition as well as patient position must be standardised and correction techniques applied. The emptying of solid and liquid meal constituents can be evaluated concomitantly. Solids start to empty only after a lag phase of varying extent. With semi-solid meals, which are emptied at the same rate as solid meals of identical composition in the postlag phase, the recording time can be considerably shorter. Besides gastric emptying, the amplitude, frequency and propagation velocity of antral contractions can be recorded using serial images of short frame time and specially devised analytic techniques. (orig.)

  6. Scintigraphic quantitation of gastrointestinal motor activity and transport: Oesophagus and stomach

    Energy Technology Data Exchange (ETDEWEB)

    Stacher, G.; Bergmann, H. (Vienna Univ. (Austria). Psychiatrische Klinik Vienna Univ. (Austria). 1. Chirurgische Klinik Ludwig-Boltzmann-Institut fuer Nuklearmedizin, Vienna (Austria))

    1992-09-01

    For the recognition and characterisation of oesophageal motor disorders, manometry represents the most reliable tool but yields no information on bolus transport. The transport can be quantitated by radionuclide techniques. The patient is positioned supine beneath a gamma-camera and instructed to swallow a radiolabelled bolus in a single gulp. Using a marker over the cricoid and the activity in the stomach as landmarks, regions of interest are drawn representing the upper, middle and lower third of the oesophagus and the gastric fundus. Activity-time curves enable one to recognise the clearance patterns in these regions. In combination, manometric and radionuclide transit studies recognise a higher number of motor disorders than either procedure alone. Radionuclide methods also are the most reliable and sensitive to quantitate gastric emptying. Procedure, meal size and composition as well as patient position must be standardised and correction techniques applied. The emptying of solid and liquid meal constituents can be evaluated concomitantly. Solids start to empty only after a lag phase of varying extent. With semi-solid meals, which are emptied at the same rate as solid meals of identical composition in the postlag phase, the recording time can be considerably shorter. Besides gastric emptying, the amplitude, frequency and propagation velocity of antral contractions can be recorded using serial images of short frame time and specially devised analytic techniques. (orig.).

  7. Scintigraphic and Radiologic Findings of Pancake Kidney in a Patient with Fanconi Aplastic Anemia

    Directory of Open Access Journals (Sweden)

    Adem Maman

    2016-06-01

    Full Text Available In this case, we have presented that a patient has fankoni aplastic anemia with pancakes kidney in scintigraphy and ultrasonography. The patient is 10 years old and a girl who fanconi aplastic anemia had been diagnosed since three years. In physical examination her general status is good. There was not left hand thumb and she had double the distal phalanx in his right hand thumb in her inspection. We observed 2/6 sistolic murmur in cardiovascular system examınation. Other systems were natural. Abdominal ultrasonography was observed that both the kidney were ectopic location and fused view in the left lower quadrant. Similarly in Tc-99m DTPA and DMSA renal scintigraphy, both kidneys were fused and in the left hemipelvis. The right kidney function were significantly lower by comparison with the left kidney functions. Radiological imaging is necessary in patients with Fanconi aplastic anemia without present clinical symptoms. The renal ultrasonography is important for determining pancakes. In addition, static and dynamic renal scintigraphy plays an important role in revealing the functional status of the kidneys

  8. Mitral valve prolapse in the ventriculogram: scintigraphic, electrocardiographic, and hemodynamic abnormalities

    International Nuclear Information System (INIS)

    Tebbe, U.; Schicha, H.; Neumann, P.; Voth, E.; Emrich, D.; Neuhaus, K.L.; Kreuzer, H.

    1985-01-01

    Patients with mitral valve prolapse (MVP) frequently have chest pain, which may be difficult to differentiate from angina pectoris in coronary artery disease (CAD). The authors performed resting and exercise ECGs, pulmonary arterial pressure measurements, radionuclide ventriculography (/sup 99m/technetium), and perfusion scintigrams ( 201 thallium) in 56 patients with angiographically proven MVP and no CAD. Pathological results were obtained in 31% of exercise ECGs, 33% of pulmonary arterial pressure measurements during exercise, 22% of radionuclide ventriculographies, and in 75% of thallium perfusion scintigrams. A significant correlation in pathological results was found only between exercise ECG and both radionuclide ventriculography and pulmonary arterial pressure measurements. Because of the high prevalence of false-positive perfusion scintigrams in patients with typical or atypical chest pain, the use of exercise 201 Tl imaging as a screening method to separate patients with MVP from those with CAD will not be appropriate. The variability of cardiac abnormalities in our patients with MVP and angiographically normal coronary arteries suggests that the MVP syndrome may represent a variable combination of metabolic, ischemic, or myopathic disorders

  9. Value of the region of interest technique in the scintigraphic diagnosis of primary bone tumors

    International Nuclear Information System (INIS)

    Buell, U.; Keyl, W.; Meister, P.; Pfeifer, J.P.; Hartel, P.; Muenchen Univ.

    1981-01-01

    Employing ROI-technique, a ratio Q was obtained from relating accumulation of 99 sup(m)Tc-MDP at the site of the bone lesion (n = 150) with that of contralateral non-involved osseous areas. Values of Q were correlated with histologic tumor diagnosis, its dignity and frequency. Values of Q of greater than 3.0 were found in 95% of all sarcomas, in 100% of the osteosarcomas but in only 3.8% of all benign bone tumors. Values ranging from 1.0 to 1.2 were exclusively measured in benign tumors (e.g., in 52% of juvenile bone cysts and in 67% of non-ossifing fibromas). Since the threshold - separating benign from malignant lesions - at Q = 3.0 was blurred by tumorlike lesions, metastases and especially by Paget's disease, this method does not precisely predict dignity. However, this method may complement radiographic evaluation with low values supporting the diagnosis of a benign lesion. The combined findings of radiography and these rations gained by nuclear imaging may help determine the pathway of a patient through further diagnosis and treatment. (orig.) [de

  10. Avascular necrosis and fracture of the capitate bone: Unusual scintigraphic features

    International Nuclear Information System (INIS)

    Mansberg, R.; Farag, M.

    1999-01-01

    Full text: A 14-year-old boy fell and injured his left wrist. A plain radiograph was reported as normal and a bone scan was performed due to persistent pain and swelling. Markedly reduced vascularity was noted in the region of the proximal carpal row of the left hand in the flow and pool phases of the study. Absent uptake was noted on the delayed images throughout the mid-carpus. Increased uptake was present in the left distal radial growth plate. The patient was treated with immobilization. A repeat bone scan 3 months later demonstrated increased vascularity and osteoblastic activity in the region of the left capitate bone. A CT scan confirmed an avascular necrosis with fragmentation and cyst formation of the capitate bone. This case, illustrates the usefulness of progress studies to diagnose the exact nature of an injury. In this particular case reduced vascularity and uptake was demonstrated on the initial study presumably due to oedema and subsequent vascular insufficiency. A progress bone scan and CT were required to confirm avascular necrosis of the capitate bone

  11. Biventricular function in sickle-cell anemia: radionuclide angiographic and thallium-201 scintigraphic evaluation

    International Nuclear Information System (INIS)

    Manno, B.V.; Burka, E.R.; Hakki, A.H.; Manno, C.S.; Iskandrian, A.S.; Noone, A.M.

    1983-01-01

    Left ventricular (LV) and right ventricular (RV) function were evaluated at rest and during exercise using radionuclide ventriculography in 10 patients, aged 19-53 years, with sickle-cell anemia (SCA). Seven patients were in New York Heart Association functional class I and 3 were in class II. The resting LV ejection fraction (EF) was normal in 9 patients and the resting RVEF was normal in 4. LV dilation and high cardiac output were observed in 6 patients at rest. The LVEF during exercise was normal in all 10 patients, whereas only 2 patients had normal RVEF at rest and during exercise. The LVEF was lower in patients with SCA at rest (54 +/- 4% versus 61 +/- 6%, p less than 0.001) and exercise (66 +/- 4% versus 74 +/- 6%, p less than 0.001) than in 42 age-matched normal subjects. Rest thallium-201 images from 9 patients showed abnormal RV uptake in 8 and normal LV uptake in 8. Thus, in adult patients with SCA, LV function was normal during exercise in all patients and at rest in all but 1 patient. The LVEF, however, was lower than that in age-matched normal subjects. RV function was abnormal in most patients at rest and during exercise. RV thallium-201 uptake suggested pressure or volume overload (or both), most likely due to pulmonary vaso-occlusive complications of the disease

  12. Scintigraphic evaluation of enterogastric reflux using 75Se-HCAT: Methodology and first clinical observations

    International Nuclear Information System (INIS)

    Furno, A.; Sciarretta, G.; Malaguti, P.; Fagioli, G.; Pozzato, R.

    1987-01-01

    The aim of this study was to assess the possibility of detecting enterogastric reflux (EGR) by 75 Se-HCAT cholescintigraphy. The lowest detectable activity in the gastric area at different concentrations of the radiotracer in the gallbladder was preliminary measured both in a plastic phantom and in an in vivo model. Ten patients were studied after a single oral administration of 1480 KBq 75 Se-HCAT. Gamma camera imaging was carried out for five consecutive days during both fasting and after meal ingestion. In our in vivo model an EGR corresponding to 1% of gallbladder content on day one and 8% on day five was detected. In three out of five patients in whom bile was present in the stomach at endoscopy, 75 Se-HCAT cholescintigraphy demonstrated an EGR, while in three out of five patients in whom endoscopy was negative, 75 Se-HCAT cholescintigrahy detected EGR either during fasting or after meal ingestion. As EGR is not constant, Se-HCAT may be a useful tracer of bile to detect EGR over a prolonged period of time and in different physiological conditions. (orig.)

  13. Scintigraphic evaluation of enterogastric reflux using /sup 75/Se-HCAT: Methodology and first clinical observations

    Energy Technology Data Exchange (ETDEWEB)

    Furno, A; Sciarretta, G; Malaguti, P; Fagioli, G; Pozzato, R

    1987-08-01

    The aim of this study was to assess the possibility of detecting enterogastric reflux (EGR) by /sup 75/Se-HCAT cholescintigraphy. The lowest detectable activity in the gastric area at different concentrations of the radiotracer in the gallbladder was preliminary measured both in a plastic phantom and in an in vivo model. Ten patients were studied after a single oral administration of 1480 KBq /sup 75/Se-HCAT. Gamma camera imaging was carried out for five consecutive days during both fasting and after meal ingestion. In our in vivo model an EGR corresponding to 1% of gallbladder content on day one and 8% on day five was detected. In three out of five patients in whom bile was present in the stomach at endoscopy, /sup 75/Se-HCAT cholescintigraphy demonstrated an EGR, while in three out of five patients in whom endoscopy was negative, /sup 75/Se-HCAT cholescintigrahy detected EGR either during fasting or after meal ingestion. As EGR is not constant, Se-HCAT may be a useful tracer of bile to detect EGR over a prolonged period of time and in different physiological conditions.

  14. Electrocardiographic and scintigraphic evaluation of patients with subclinical hyperthyroidism during workout.

    Science.gov (United States)

    Kaminski, Grzegorz; Dziuk, Mirosław; Szczepanek-Parulska, Ewelina; Zybek-Kocik, Ariadna; Ruchala, Marek

    2016-08-01

    Subclinical hyperthyroidism (sHT) was found to be associated with elevated heart rate, blood pressure and increased risk of extrasystoles. However, the full clinical relevance of morphological and functional implications of sHT on the cardiovascular system is still a matter of debate. The aim of the study was to prospectively assess the influence of endogenous sHT on exercise capacity and cardiac function during workout with the use of exercise electrocardiography (ExECG) and perfusion scintigraphy. The studied group consisted of 44 consecutively recruited patients diagnosed with sHT. In all patients, ExECG, followed by post-exercise myocardial perfusion imaging, was performed. Both ExECG and scintigraphy were performed twice-in the state of sHT and after euthyroidism was restored. An average time period of exercise test was significantly longer in the state of euthyroidism than in sHT. An average oxygen consumption during exercise test was also higher after euthyroidism was achieved when compared to sHT. The end-diastolic and end-systolic volume indexes, stroke volume index and cardiac index were significantly larger in patients with sHT if compared values achieved after euthyroidism restoration. Stroke volume index was negatively correlated with TSH, and positively with free thyroid hormones values in the state of sHT, before euthyroidism was achieved. Cardiac index was positively correlated with free thyroid hormones levels. The obtained results indicate worse physical capacity in subjects with sHT and improvement of several parameters assessed during ExECG and perfusion scintiscan after therapy. Observed changes might reflect the mechanism of the deleterious effect exerted by sHT on the heart.

  15. [Regional liver circulation and the scintigraphic representation of the portal circulation with 133Xe].

    Science.gov (United States)

    Kroiss, A

    1984-01-01

    Regional hepatic blood flow has been determined by 4 methods with the aid of the 133Xe washout technique: scintisplenoportography (direct application of 133Xe into the spleen by means of a thin needle); arterial method (133Xe is injected into the A. hepatica by means of a catheter); retrograde-venous method (133Xe administered by an occluding hepatic vein catheter); percutaneous intrahepatic method (133Xe administered directly into the parenchyma by means of a Chiba needle). Ad 1.: Scintisplenoportography (SSP) was executed with 97 patients: 8 patients with a healthy liver presented a hepatic blood flow of 103.37 +/- 11.5 ml/100 g/min. 4 patients with a chronic hepatitis showed a hepatic blood flow of 105.67 +/- 10.2 ml/100 g/min. In 38 patients with compensated cirrhosis, hepatic blood flow was determined with 58.15 +/- 11.5 ml/100 g/min and 19 patients with decompensated cirrhosis showed a blood flow of 34.54 +/- 7.2 ml/100 g/min. Of the 19 patients, who did not present any liver image, 2 patients suffered from a prehepatic block, 1 patient (female) from a posthepatic block, the rest were decompensated cirrhoses. In 5 patients suffering from steatosis only collateral circulation was determined and in 4 patients the spleen could not be punctured. In the patients with compensated and decompensated cirrhosis of the liver, hepatic blood flow differentiated significantly (p less than 0.001) from patients with healthy livers and chronic hepatitis. In the patients with bioptically assured steatosis only the washout constant was determined. Reproducibility of this method was tested in 4 patients and no statistical difference of hepatic blood flow values could be found and the correlation coefficient amounted to 0.9856. The advantage of SSP lies in the possibility of recording the portal vein circulation: cranial collaterals were found in 33 patients, 2 patients had caudal collaterals exclusively and 29 patients cranial and caudal collaterals. 33 cirrhosis patients

  16. Marginal zone in femoral head avascular necrosis: scintigraphic characteristics and clinical prognostic value

    International Nuclear Information System (INIS)

    Milcinski, M.; Sedonja, I.; Dolinar, D.; Jevtic, V.

    2002-01-01

    Aim: Marginal zone, seen on magnetic resonance imaging (MRI) in femoral head avascular necrosis, consists of granulation tissue and sclerosis at the junction of necrotic and normal bone. Prognostic value of this finding is not clear. Aim of our study was to evaluate osteoblastic activity of marginal zone with bone scintigraphy and to assess prognostic importance of marginal zone for further evolution of femoral head necrosis. Material and methods: MRI was performed in 37 hips in 26 patients (17 m, 9 f, 20-64 y, mean 42,9 y) with Ficat 0-II avascular necrosis (SE T1W, STIR and SE T1W FAT.SAT after Gd DTPA in the coronal plane and GE FLASH in the sagittal plane). In 26 hips of 17 patients planar and pinhole scintigraphy with 99mTc-DPD was performed. Results: On MRI, marginal zone divided necrotic and normal bone in 26/37 (70,3%) hips, in 14/26 it was thin (2% of femoral head diameter or less), but in 12/26 it was wide (more than 2% of femoral head diameter). In 11/37 (29,7%) hips marginal zone was not seen. Pinhole scintigraphy was performed in 26 hips; in all 10/10 (100%) hips with wide marginal zone, seen on MRI, increased osteoblastic activity was detected, while only in 1/9 (11,1%) hips with thin marginal zone on MRI osteoblastic activity was increased. Patients were followed 1 to 5 years (mean 2,2 y). In hips without marginal zone no collapse of femoral head was seen until now, in 2/11 (18,2%) femoral heads MRI and clinical regression was observed. Ten of 12 lesions with wide marginal zone (83,3 %) collapsed 0,25 to 2,5 (mean 1) years after onset of pain. Two of 12 lesions with wide marginal zone (16,7%) have not collapsed until now. From lesions with thin marginal zone, 4/14 (28,6 %) collapsed 0,7 to 3 (mean 1,9) years after onset of pain, 10/14 (71,4%) did not collapse until now. Conclusion: Increased osteoblastic activity in wide marginal zone between necrotic and vital bone in hip avascular necrosis is bad prognostic factor for femoral head collapse

  17. Scintigraphic assessment of cerebral blood flow changes in chrongic tobacco users using Tc-99m HMPAO brain SPECT

    International Nuclear Information System (INIS)

    Saeed, S.; Raza, M.; Sohaib, M.

    2004-01-01

    HMPAO SPECT is a useful and readily available method for estimation of rCBE This study aimed at defining a correlation between chronic tobacco use and changes in cerebral blood flow, through visual and semi-quantitative scintigraphic assessment, rCBF in 48 chronic tobacco users and 11 quitters was evaluated, utilising a normal database created by HMPAO brain scans of 20 non-smokers. Subjects were classified into chronic tobacco users and non-tobacco users through the smoking index (SI). SI value of 100 was taken as the cut-off value. Tobacco users who had discontinued tobacco use for three months or more were classified as 'Quitters'. ROIs were declared hypo- or hyper-perfused if their percentage perfusion values relative to the average perfusion per pixel of the whole slice did not fall within + 2 SD of the mean regional perfusion in the corresponding ROI, in the normal control group.rCBF in chronic tobacco users was found to be far less than the non-tobacco users (P < 0.001). The quitters showed significantly better cerebral perfusion compared to the chronic tobacco users (P < 0.025) but their rCBF was still significantly decreased relative to the non-tobacco users (P < 0.005). In chronic tobacco users, the rCBF was decreased in parietal (P < 0.05) and occipital (P < 0.005) regions of the cortex, and increased in the temporal cortex (P < 0.001). The frontal cortex showed both hyperperfusion (P < 0.001) and hypoperfusion (P < 0.025), perhaps due to varying perfusion patterns in different areas / sub-regions of the frontal cortex. The cerebellar blood flow in chronic tobacco users was much decreased compared to the normal controls (P < 0.001).Generally, a satisfactory correlation between the results obtained visually and semi-quantitatively was found. Semi-quantitative approach, however, appeared better specially when regional radiotracer uptake (actual acquired average regional counts) were used as an adjunct to support the findings. (authors)

  18. Cervical SPECT Camera for Parathyroid Imaging

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2012-08-31

    Primary hyperparathyroidism characterized by one or more enlarged parathyroid glands has become one of the most common endocrine diseases in the world affecting about 1 per 1000 in the United States. Standard treatment is highly invasive exploratory neck surgery called Parathyroidectomy. The surgery has a notable mortality rate because of the close proximity to vital structures. The move to minimally invasive parathyroidectomy is hampered by the lack of high resolution pre-surgical imaging techniques that can accurately localize the parathyroid with respect to surrounding structures. We propose to develop a dedicated ultra-high resolution (~ 1 mm) and high sensitivity (10x conventional camera) cervical scintigraphic imaging device. It will be based on a multiple pinhole-camera SPECT system comprising a novel solid state CZT detector that offers the required performance. The overall system will be configured to fit around the neck and comfortably image a patient.

  19. Two-Dimensional Image Fusion of Planar Bone Scintigraphy and Radiographs in Patients with Clinical Scaphoid Fracture: An Imaging Study

    DEFF Research Database (Denmark)

    Henriksen, O.M.; Lonsdale, M.N.; Jensen, T.D.

    2008-01-01

    . Bone scintigraphy is highly sensitive for the detection of fractures, but exact localization of scintigraphic lesions may be difficult and can negatively affect diagnostic accuracy. Purpose: To investigate the influence of image fusion of planar bone scintigraphy and radiographs on image interpretation......Background: Although magnetic resonance imaging (MRI) is now considered the gold standard in second-line imaging of patients with suspected scaphoid fracture and negative radiographs, bone scintigraphy can be used in patients with pacemakers, metallic implants, or other contraindications to MRI....... Conclusion: Image fusion of planar bone scintigrams and radiographs has a significant influence on image interpretation and increases both diagnostic confidence and interobserver agreement Udgivelsesdato: 2008/12/3...

  20. Scintigraphic examinations in neuroradiology

    Energy Technology Data Exchange (ETDEWEB)

    Emde, H [Universitaet des Saarlandes, Homburg/Saar (Germany, F.R.). Abt. fuer Neuroradiologie

    1979-06-01

    The introduction of CT in neuroradiological diagnostics has clearly lowered the interest in nuclear examinations. Frequently, these are carried only out of a lack of CT capacity. Still, some examples are given to show how useful cerebral, bone, and cerebrospinal fluid scintiscanning can be in every day routine diagnostics.

  1. Possible role of the scintigraphic estimation of the relative liver perfusion in the choice of treatment of liver carcinomas

    International Nuclear Information System (INIS)

    Artiko, V.; Obradovic, V.; Davidovic, B.; Petrovic, N.; Vlajkoviae, M.; Kostic, K.

    2005-01-01

    Full text: In the pre-evaluation and diagnosis of the patients with liver tumors, significant nuclear medicine methods used are: radiocolloid, blood pool, hepatobiliary scintigraphy, angioscintigraphy with radiolabeled microspheres as well as 'first pass' radionuclide angiography, which can precede all of the above mentioned methods, during single injection application. The aim of the study is evaluation of the possible role of the scintigraphic estimation of the relative liver perfusion in the choice of treatment of liver carcinomas. The study was performed in 120 patients: 24 controls (C), 35 with benign liver tumors (BT), 35 with hepatocellular carcinomas (HCC), 19 with metastases of colorectal carcinomas (MCC) as well as 7 with metastases of other tumors (MOT-bronchus, lung carcinoma and lymphoma). 7/35 HCC had cavernous portal vein developed after tumor thrombosis, 2 had complete thrombosis and 5 had incomplete thrombosis (thrombosis of the either of portal venous branches (3) and incomplete portal venous thrombosis -2). 2/19 patients with MCC had cavernous portal vein developed after tumor thrombosis, 3 had complete portal venous occlusion and 4 incomplete thrombosis (thrombosis of the either of branches). The study was performed with ROTA scintillation camera and Micro Delta computer, during 60 sec (1f/sec) from i.v.application of 740 MBq 99mTc-pertecnetate. TA curves were generated using liver ROI, spleen ROI and left kidney ROI, and curves were generated. Hepatic perfusion index was calculated using slope analysis (Portal slope Ps and arterial slope As) method according to following formula HPI=Ps/(Ps+As). Complementary methods used were Doppler ultrasonography, CT, MRI, tumor marker assays (CEA, Ca19-9, AFP) laboratory analyses, pathohistological finding and clinical diagnosis. In C, HPI was 0.68±0.06 which did not differ from the value in BT (0.64 ±0.08) (p>0.05). However, in HCC ( X=0.26±0.20), and LM (X=0.40±0.28), HPI values were significantly

  2. Diagnostic accuracy of scintigraphic methods in the differential diagnosis of focal liver lesions. Stellenwert nuklearmedizinischer Methoden in der Differentialdiagnose solider Leberherde

    Energy Technology Data Exchange (ETDEWEB)

    Czermak, H. (Nuklearmedizinische Abt., LKH Klagenfurt (Austria)); Gomez, I. (Nuklearmedizinische Abt., LKH Klagenfurt (Austria)); Gallowitsch, H.J. (Nuklearmedizinische Abt., LKH Klagenfurt (Austria)); Lind, P. (Nuklearmedizinische Abt., LKH Klagenfurt (Austria))

    1993-08-01

    In a retrospective study of 160 patients who were examined within 12 months, we analysed the diagnosic value of scintigraphic techniques in the differential diagnosis of solid focal liver lesions. Haemangiomas were found in 77 patients. Bloodpool scintigraphy was true-positive in 66 (sensivitity 85%); for lesions greater than 2 cm in diameter, sensitivity increased to 94%. Metastases of CEA-expressing tumors were found in 42 patients, anti-CEA-immunoscintigraphy was true-positive in 33 patients (sensitivity 78.5%). Focal nodulary hyperplasia was found in 3 patients, adenomas in 6 patients. In the remaining 32 patiens we saw 4 hepatocellular carcinomas, 28 metastases from lung and breast cancer, 2 echinococcus cysts and 1 choledochus cyst. (orig.)

  3. Renal imaging in paediatrics

    International Nuclear Information System (INIS)

    Porn, U.; Hahn, K.; Fischer, S.

    2003-01-01

    The most frequent renal diseases in paediatrics include urinary tract infections, hydronephrosis, kidney anomalies and reflux. The main reason for performing DMSA scintigraphy in paediatrics is the detection of cortical abnormalities related to urinary tract infection. Because the amount of tracer retained in the tubular cells is associated with the distribution of functioning renal parenchyma in the kidney, it is possible, to evaluate the split renal function. In comparison to ultrasound and intravenous urography the sensitivity in the detection of acute as well as chronic inflammatory changes is very high, however less specific. An indication for a renography in neonates and children is beside an estimation of the total renal function and the calculation of the split renal function, the assessment of renal drainage in patients with unclear dilatation of the collecting system in ultrasound. The analysis of the time activity curve provides, especially for follow-up studies, a reproducible method to assess the urinary outflow. The diuretic scintigraphy allows the detection of urinary obstruction. Subsequently it is possible to image the micturition phase to detect vesico-ureteric reflux (indirect MCU) after drainage of tracer from the renal pelvis. An reflux in the ureters or the pelvicalyceal system is visible on the scintigraphic images and can be confirmed by time activity curves. A more invasive technique is the direct isotope cystography with bladder catheterization. The present paper should give an overview about the role of nuclear medicine in paediatric urology. (orig.) [de

  4. Technetium-99m stannous pyrophosphate imaging of experimental infective endocarditis

    International Nuclear Information System (INIS)

    Riba, A.L.; Downs, J.; Thakur, M.L.; Gottschalk, A.; Andriole, V.T.; Zaret, B.L.

    1978-01-01

    Technetium-99m stannous pyrophosphate (/sup 99m/Tc-PYP) cardiac scintigraphy was performed in 15 rabbits with experimental Streptococcus sanguis aortic-valve infective endocarditis. The animals were imaged five to seven days after the administration of bacteria, and in each case abnormal accumulation of the tracer was visualized in the region of the aortic valve. Three types of cardiac scintigraphic patterns were demonstrated: focal, multifocal, and extensive, each correlating well with the anatomical extent of the lesion as defined by gross pathology. Tissue distribution studies demonstrated a 30 +- 5.3 (mean +- SEM) fold excess of radionuclide uptake in the infective endocarditis lesion compared with that of normal myocardium. Imaging of excised hearts from four animals showed an excellent correlation with in vivo imaging as well as gross pathology. Five animals with nonbacterial thrombotic aortic valve endocarditis demonstrated similar scintigraphic and tissue distribution results. In contrast, four normal animals failed to demonstrate abnormal /sup 99m/Tc-PYP cardiac scintigrams or tissue uptake. This study demonstrates that /sup 99m/Tc-PYP cardiac scintigraphy is a sensitive technique to detect experimental aortic valve endocarditis

  5. Use of a knowledge synthesis by decision makers and planners to facilitate system level integration in a large Canadian provincial health authority

    Directory of Open Access Journals (Sweden)

    Esther Suter

    2011-03-01

    Full Text Available Purpose: The study is an examination of how a knowledge synthesis, conducted to fill an information gap identified by decision makers and planners responsible for integrating health systems in a western Canadian health authority, is being used within that organisation. Methods: Purposive sampling and snowball technique were used to identify 13 participants who were interviewed about how they are using the knowledge synthesis for health services planning and decision-making. Results: The knowledge synthesis is used by those involved in the strategic direction of the provincial healthcare organisation and those tasked with the operationalization of integration at the provincial or local level. Both groups most frequently use the ten key principles for integration, followed by the sections on integration processes, strategies and models. The key principles facilitate discussion on priority areas to be considered and provide a reference point for a desired future state. Perceived information gaps relate to a lack of detail on "how to" strategies, tools and processes that would lead to successful integration. Discussion and conclusion: The current project demonstrates that decision makers and planners will effectively use a knowledge synthesis if it is timely, relevant and accessible. The information can be applied at strategic and operations levels. Attention needs to be paid to include more information on implementation strategies and processes. Including knowledge users in identifying research questions will increase information uptake.

  6. Use of a knowledge synthesis by decision makers and planners to facilitate system level integration in a large Canadian provincial health authority

    Directory of Open Access Journals (Sweden)

    Esther Suter

    2011-03-01

    Full Text Available Purpose: The study is an examination of how a knowledge synthesis, conducted to fill an information gap identified by decision makers and planners responsible for integrating health systems in a western Canadian health authority, is being used within that organisation.Methods: Purposive sampling and snowball technique were used to identify 13 participants who were interviewed about how they are using the knowledge synthesis for health services planning and decision-making.Results: The knowledge synthesis is used by those involved in the strategic direction of the provincial healthcare organisation and those tasked with the operationalization of integration at the provincial or local level. Both groups most frequently use the ten key principles for integration, followed by the sections on integration processes, strategies and models. The key principles facilitate discussion on priority areas to be considered and provide a reference point for a desired future state. Perceived information gaps relate to a lack of detail on "how to" strategies, tools and processes that would lead to successful integration.Discussion and conclusion: The current project demonstrates that decision makers and planners will effectively use a knowledge synthesis if it is timely, relevant and accessible. The information can be applied at strategic and operations levels. Attention needs to be paid to include more information on implementation strategies and processes. Including knowledge users in identifying research questions will increase information uptake.

  7. Whole body imaging in the abdominal cancer patient: pitfalls of PET-CT.

    LENUS (Irish Health Repository)

    McDermott, Shaunagh

    2012-02-01

    Proper interpretation of PET-CT images requires knowledge of the normal physiological distribution of the tracer, frequently encountered physiological variants, and benign pathological causes of FDG uptake that can be confused with a malignant neoplasm. In addition, not all malignant processes are associated with avid tracer uptake. A basic knowledge of the technique of image acquisition is also required to avoid pitfalls such as misregistration of anatomical and scintigraphic data. This article reviews these potential pitfalls as they apply to the abdomen and pelvis of patients with cancer.

  8. Skeletal MR imaging: Correlation with skeletal scintigraphy

    International Nuclear Information System (INIS)

    Colletti, P.M.; Raval, J.K.; Ford, P.V.; Benson, R.C.; Kerr, R.M.; Boswell, W.D.; Siegel, M.E.; Ralls, P.W.

    1987-01-01

    Skeletal MR images bone marrow while skeletal scintigraphy uses bone metabolism to demonstrate abnormalities. The purpose of this paper is to correlate these MR and scintigraphic findings. T1 and T2 MR images at 0.5 T were correlated with planar bone scintigraphy (RN) using Tc-99m MDP in 56 patients. Of 23 cases with suspected spinal metastases, 19 were positive by MR imaging, 16 by RN. Individual lesions were shown better by MR imaging in five and by RN in two. These two cases had scoliosis, a potential difficulty with MR imaging. In 14 cases of suspected avascular necrosis (AVN), MR imaging was positive in 13 while RN was positive in ten. One negative case by RN had bilateral AVN by MR imaging. Four skull lesions shown easily by RN were seen only in retrospect on MR images. MR imaging is advantageous in evaluating bones with predominant marrow such as vertebrae or the femoral head, while RN is superior in areas primarily composed of cortical bone such as the skull

  9. Abnormal I-123 HIPDM images in various disease entities

    International Nuclear Information System (INIS)

    Shih, W.J.; Magoun, S.; Coupal, J.J.; Clark, D.B.; Dekosky, S.T.; Kung, H.F.; Beihn, R.; Ryo, U.Y.

    1987-01-01

    Eighty patients who were referred from neurology service for evaluation of stroke, Alzheimer disease (AD), and/or other neurologic diseases underwent the study. Four views of planar images were obtained following the intravenous injection of 3-5 mCi of I-123 HIPDM. SPECT images were then obtained using a camera interfaced to a PDP-11 computer. Forty of the 80 patients had scintigraphic findings of stroke, which correlated well with head CT/cerebral angiogram. Sixteen patients with AD had good correlation between the degree of temporoparietal abnormality in the images. Severe AD and severe stroke patients almost always had a positive planar image. Normal I-123 HIPDM localization in the brain requires intact cerebral flow and cerebral neuronal function. A focal area of decreased I-123 HIPDM localization may represent either interruption of blood flow or neurochemical dysfunction

  10. Radionuclide imaging of the liver in human fascioliasis

    International Nuclear Information System (INIS)

    Rivera, J.V.; Bermudez, R.H.

    1984-01-01

    The clinical, laboratory, and scintigraphic findings in four cases of human fascioliasis are described. Acute onset of fever, abdominal pain, and weight loss in a person who has ingested watercress constitutes the clinical syndrome often seen. Eosinophilia and alteration in liver function tests, particularly alkaline phosphatase are frequent. Tc-99m sulfur colloid images showed hepatomegaly in four patients, focal defects in two, splenomegaly in three, and increased splenic uptake in two. Gallium citrate (Ga 67) images show increased uptake in the focal lesions in two of two. Sonographic imaging showed focal lucent abnormality in one of three. Liver biopsy findings were nonspecific. The differential diagnosis from other invasive parasitic diseases is discussed. A possible role of hepatic imaging in the evaluation of fascioliasis is suggested

  11. Energy-optimised planning and operation of UPS installations. Guidelines for planners and operators; Energieoptimierte Planung und Betrieb von USV-Anlagen. Ein Leitfaden fuer Planer und Betreiber

    Energy Technology Data Exchange (ETDEWEB)

    Neyer, A.; Schnyder, G.; Mauchle, P.

    2004-09-15

    This comprehensive brochure elaborated for the Swiss Federal Office of Energy (SFOE) is one of a set of nine reports that provide an overall review of the energy-efficiency of UPS systems. This brochure for planners and operators of UPS installations takes a look at how UPS installations can be optimised in order to reduce losses and to provide optimal operation as far as energy efficiency is concerned. The brochure explains the various types of UPS systems and their use and gives tips on ordering. Operational modes, load considerations, system configuration and specifications for putting to tender are looked at, as are the requirements to be placed on the systems for optimal operation. Basic rules for planning activities are quoted. Finally, rotating UPS installations and dynamic energy storage are briefly looked at. The paper is completed with checklists and a quality/energy-matrix.

  12. {sup 99m}Tc-HYNIC-spermine for imaging polyamine transport system-positive tumours: preclinical evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Pesnel, Sabrina [Institut de Recherche Pierre Fabre, Centre de Recherche en Oncologie Experimentale, Toulouse (France); UPS TAAM - CIPA, CNRS, Orleans (France); Guminski, Yves; Imbert, Thierry [Institut de Recherche Pierre Fabre, Division de Chimie Medicinale III, Castres (France); Pillon, Arnaud; Guilbaud, Nicolas; Kruczynski, Anna; Bailly, Christian [Institut de Recherche Pierre Fabre, Centre de Recherche en Oncologie Experimentale, Toulouse (France); Lerondel, Stephanie [UPS TAAM - CIPA, CNRS, Orleans (France); Le Pape, Alain [UPS TAAM - CIPA, CNRS, Orleans (France); Universite Francois Rabelais, INSERM U618, Tours (France)

    2011-10-15

    F14512 exploiting the polyamine transport system (PTS) for tumour cell delivery has been described as a potent antitumour agent. The optimal use of this compound will require a probe to identify tumour cells expressing a highly active PTS that might be more sensitive to the treatment. The aim of this study was to design and characterize a scintigraphic probe to evaluate its uptake in cancer cells expressing the PTS. Three polyamines coupled to a hydrazinonicotinamide (HYNIC) moiety were synthesized and labelled with {sup 99m}Tc. Their radiochemical purity was determined by HPLC. The plasma stability of the {sup 99m}Tc-HYNIC-spermine probe and its capacity to accumulate into PTS-active cells were also evaluated. In vitro internalization was tested using murine melanoma B16/F10 cells and human lung carcinoma A549 cells. Biodistribution was determined in healthy mice and tumour uptake was studied in B16/F10 tumour-bearing mice. A HL-60-Luc human leukaemia model was used to confront single photon emission computed tomography (SPECT) images obtained with the {sup 99m}Tc-labelled probe with those obtained by bioluminescence. The {sup 99m}Tc-HYNIC-spermine probe was selected for its capacity to accumulate into PTS-active cells and its stability in plasma. In vitro studies demonstrated that the probe was internalized in the cells via the PTS. In vivo measurements indicated a tumour to muscle scintigraphic ratio of 7.9{+-}2.8. The combined bioluminescence and scintigraphic analyses with the leukaemia model demonstrated that the spermine conjugate accumulates into the tumour cells. The {sup 99m}Tc-HYNIC-spermine scintigraphic probe is potentially useful to characterize the PTS activity of tumours. Additional work is needed to determine if this novel conjugate may be useful to analyse the PTS status of patients with solid tumours. (orig.)

  13. Planning applications in image analysis

    Science.gov (United States)

    Boddy, Mark; White, Jim; Goldman, Robert; Short, Nick, Jr.

    1994-01-01

    We describe two interim results from an ongoing effort to automate the acquisition, analysis, archiving, and distribution of satellite earth science data. Both results are applications of Artificial Intelligence planning research to the automatic generation of processing steps for image analysis tasks. First, we have constructed a linear conditional planner (CPed), used to generate conditional processing plans. Second, we have extended an existing hierarchical planning system to make use of durations, resources, and deadlines, thus supporting the automatic generation of processing steps in time and resource-constrained environments.

  14. The Architect, the Planner and the Bishop: the Shapers of ‘Ordinary’ Dublin, 1940–60

    Directory of Open Access Journals (Sweden)

    Ellen Rowley

    2015-12-01

    Full Text Available From the 1930s through the 1960s, Dublin’s development occurred at its periphery: wheels of narrow roadways punctuated by green spaces provided the low-density frameworks for terraced residential boxes surmounted by pitched roofs and fronted by pocket gardens. Vast structures of ecclesiastic authority, Catholic (determinedly revivalist church building and the suite of Catholic (tentatively modernist schools were presented as support structures for mass housing, thereby completing the image and experience of Dublin’s new mid-twentieth-century suburbs.Taking the 1950s genesis of one vast north Dublin neighbourhood, Raheny/Coolock, as a case study, this paper sets previously unexamined archive material from the local Catholic bishopric and Dublin Corporation alongside critical thinking about Irish Catholicism and postwar suburbia generally. Startling hand-drawn maps by local priests reveal how John Charles McQuaid, archbishop of Dublin from 1940–71, influenced Dublin’s planning processes and controlled the architectural flavour of swathes of developing parishes. This paper seeks to unpick the variously silent and active roles of the architect, the planning office, the patron and the user, in the making of the more recent, everyday built environment that is Irish suburbia.

  15. Is it time for cardiac innervation imaging?

    Energy Technology Data Exchange (ETDEWEB)

    Knuuti, J. [Turku Univ., Turku (Finland) Turku PET Center; Sipola, P. [Kuopio Univ., Kuopio (Finland)

    2005-03-01

    The autonomic nervous system plays an important role in the regulation of cardiac function and the regional distribution of cardiac nerve terminals can be visualized using scintigraphic techniques. The most commonly used tracer is iodine-123-metaiodobenzylguanidine (MIBG) but C-11-hydroxyephedrine has also been used with PET. When imaging with MIBG, the ratio of heart-to-mediastinal counts is used as an index of tracer uptake, and regional distribution is also assessed from tomographic images. The rate of clearance of the tracer can also be measured and indicates the function of the adrenergic system. Innervation imaging has been applied in patients with susceptibility to arrythmias, coronary artery disease, hypertrophic and dilated cardiomyopathy and anthracycline induced cardiotoxicity. Abnormal adrenergic innervation or function appear to exist in many pathophysiological conditions indicating that sympathetic neurons are very susceptible to damage. Abnormal findings in innervation imaging also appear to have significant prognostic value especially in patients with cardiomyopathy. Recently, it has also been shown that innervation imaging can monitor drug-induced changes in cardiac adrenergic activity. Although innervation imaging holds great promise for clinical use, the method has not received wider clinical acceptance. Larger randomized studies are required to confirm the value of innervation imaging in various specific indications.

  16. Condensed images for evaluating gastric motility patterns

    Energy Technology Data Exchange (ETDEWEB)

    Tatsch, K.; Schroettle, W.; Kirsch, C.-M. (Munich Univ. (Germany, F.R.). Dept. of Radiology)

    1991-04-01

    A condensed imaging technique was applied to gastric emptying studies to investigate (a) whether different types of motility disorders may be distinguished by characteristic image patterns and (b) whether the findings obtained provide additional information compared to standard quantitative measurements. Condensed images and quantitative data of gastric emptying were evaluated in 75 consecutive patients with normal function and various disorders such as peptic ulcer, postvagotomy, pyloric obstruction, dumping syndrome, gastoparesis etc. Condensed images were generated from a gastric region of interest. They display the distribution and behaviour of a radioactive test meal in a space-time matrix, whose horizontal and vertical dimensions are temporal and spatial, respectively. As shown in a series of representative examples condensed images disclose a variety of well-defined image patterns reflecting different pathophysiological mechanisms. This qualitative characterization of gastric emptying patterns provided in 34 of the 75 patients (45%) important new information compared to quantitative data. The application of condensed imaging techniques to gastric emptying studies (complementary to quantitative measurements) may, therefore, enhance the diagnostic value of scintigraphic techniques. (author).

  17. Scintigraphic assessment of cardiac sympathetic innervation with I-123-metaiodobenzylguanidine in cardiomyopathy. Special reference to cardiac arrhythmia

    Energy Technology Data Exchange (ETDEWEB)

    Asano, Takahisa; Otsuka, Nobuaki; Sone, Teruki; Mimura, Hiroaki; Yanagimoto, Shinichi; Tomomitsu, Tatsushi; Fukunaga, Masao [Kawasaki Medical School, Kurashiki, Okayama (Japan); Morita, Koichi

    1999-07-01

    Cardiac sympathetic imagings with I-123-metaiodobenzylguanidine (MIBG) were carried out in 5 cases with dilated cardiomyopathy (DCM), 26 cases with hypertrophic cardiomyopathy (HCM), and 4 cases without cardiac disease as a control to assess cardiac sympathetic innervation qualitatively and quantitatively, and to clarify the relation of MIBG accumulation to arrhythmia. MIBG scintigraphy was performed at 15 min. (early image) and 4 hr. (delayed image) after intravenous injection of MIBG 111 MBq. The MIBG uptake ratio of mediastinum (H/M) and the cardiac washout rate (WR) from early to delayed images were calculated. On both early and delayed SPECTs, MIBG uptake was assessed by defect scores (DSs). Regarding the cases with HCM, the MIBG uptake ratio, WR, and DS were also compared in cases with and without arrhythmia. In DCM, the MIBG uptake on delayed SPECT was markedly low, the H/M ratio was significantly lower, and the DS was significantly higher than in the control (all p<0.05). As for the WR, there was no significant difference between HCM, DCM and the control. In HCM, significantly reduced MIBG uptake was observed in cases with ventricular techycardia (VT) and in cases with atrial fibrillation (Af), as compared with cases without arrhythmia (all p<0.05). There results suggest that MIBG scintigraphy might be a useful tool in the assessment of cardiac sympathetic abnormalities in cardiomyopathy, especially in cases with arrhythmia. (author)

  18. In-111-octreotide is superior to I-123-metaiodobenzylguanidine for scintigraphic detection of head and neck paragangliomas

    NARCIS (Netherlands)

    Koopmans, Klaas Pieter; Jager, Pieter L.; Kema, Ido P.; Kersten, Michiel N.; Albers, Frans; Dullaart, Robin P. F.

    In this study, we evaluated the diagnostic yield of somatostatin receptor scintigraphy (SRS), 1-metaiodobenzylguanidine (MIBG) scintigraphy, and morphologic imaging (CT or MRI) in patients with head and neck paragangliomas. Methods: In a university hospital setting, patients considered to have head

  19. A proposal to study the esophageal transit by biomagnetic and scintigraphic study; Uma nova proposta para o estudo do transito esofagiano atraves das tecnicas biomagneticas e cintilograficas

    Energy Technology Data Exchange (ETDEWEB)

    Daghastanli, N.A.; Braga, F.J.H.N.; Baffa, O. [Sao Paulo Univ., Ribeirao Preto, SP (Brazil). Faculdade de Filosofia, Ciencias e Letras. Dept. de Fisica; Oliveira, R.B. [Faculdade de Medicina de Ribeirao Preto, SP (Brazil)

    1996-12-31

    The initial results for a new apparatus to study the esophageal transit time is studied in asymptomatic persons for a yogurt bolus (10 ml). The bolus is uniformly labeled with 5 g of ferrite powder (biomagnetic study, B) or 350 MBq of {sup 99m} Tc (scintigraphic study, C). For the B study the detection is made by means two pair of coils in opposite phase excited by a 10 k Hz sinusoidal voltage. The signal response is obtained when the bolus traverses the coils placed on the regions-of-interest (ROIs) of the esophagus (furcula, F and xiphoid process, X) and produces a signal voltage that is measured by a lock-in amplifier Stanford SR530. For C studies an Orbiter Siemens scintillation camera is used linked to a computer. The data analysis shows a (4.1{+-}0.7)s in B studies and (3.7{+-}0.9)s in C studies (R=0.6, P<0.07) 8 refs., 3 figs.

  20. Lynch, Urry and city marketing: Taking advantage of the city as a built and graphic image

    NARCIS (Netherlands)

    Hospers, G-J.

    2009-01-01

    City marketing is usually addressed from the perspective of marketing theory. This article follows an alternative approach by exploring city marketing from the viewpoint of urban planning and the sociology of tourism. In his classic ‘The Image of the City’ (1960), planner Kevin Lynch found that