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Sample records for pinnatifida harvey suringar

  1. In vitro and in vivo evaluation of anti-arthritic, antioxidant efficacy of fucoidan from Undaria pinnatifida (Harvey) Suringar.

    Science.gov (United States)

    Phull, Abdul-Rehman; Majid, Muhammad; Haq, Ihsan-Ul; Khan, Muhammad Rashid; Kim, Song Ja

    2017-04-01

    Seaweed and their constituents have been traditionally employed for the management of various human pathologic conditions such as edema, urinary disorders and inflammatory anomalies. The current study was performed to investigate the antioxidant and anti-arthritic effects of fucoidan from Undaria pinnatifida. A noteworthy in vitro antioxidant potential at 500μg/ml in 2, 2-diphenyl-1-picrylhydrazyl scavenging assay (80% inhibition), nitrogen oxide inhibition assay (71.83%), hydroxyl scavenging assay (71.92%), iron chelating assay (73.55%) and a substantial ascorbic acid equivalent reducing power (399.35μg/mg ascorbic acid equivalent) and total antioxidant capacity (402.29μg/mg AAE) suggested fucoidan a good antioxidant agent. Down regulation of COX-2 expression in rabbit articular chondrocytes in a dose (0-100μg) and time (0-48h) dependent manner, unveiled its in vitro anti-inflammatory significance. In vivo carrageenan induced inflammatory rat model demonstrated a 68.19% inhibition of inflammation whereas an inflammation inhibition potential of 79.38% was recorded in anti-arthritic complete Freund's adjuvant-induced arthritic rat model. A substantial ameliorating effect on altered hematological and biochemical parameters in arthritic rats was also observed. Therefore, findings of the present study prospects fucoidan as a potential antioxidant that can effectively abrogate oxidative stress, edema and arthritis-mediated inflammation and mechanistic studies are recommended for observed activities.

  2. High genetic diversity in gametophyte clones of Undaria pinnatifida from Vladivostok, Dalian and Qingdao revealed using microsatellite analysis

    Institute of Scientific and Technical Information of China (English)

    SHAN Tifeng; PANG Shaojun; LIU Feng; XU Na; ZHAO Xiaobo; GAO Suqin

    2012-01-01

    Breeding practice for Undaria pinnatifida (Harvey) Suringar requires the screening of a large number of offspring from gametophyte crossings to obtain an elite variety for large-scale cultivation.To better understand the genetic relationships of different gametophyte cultures isolated from different sources,20 microsatellite loci were screened and 53 gametophyte clone cultures analyzed for U.pinnatifida isolated from wild sporophytes in Vladivostok,Russia and from cultivated sporophytes from Dalian and Qingdao,China.One locus was abandoned because of poor amplification.At the sex-linked locus of Up-AC-2A8,3 alleles were detected in 25 female gametophyte clones,with sizes ranging from 307 to 316 bp.At other loci,3 to 7 alleles were detected with an average of 4.5 alleles per locus.The average number of alleles at each locus was 1.3 and 3.7 for Russian and Chinese gametophyte clones,respectively.The average gene diversity for Russian,Chinese,and for the combined total of gametophyte clones was 0.1,0.4,and 0.5,respectively.Russian gametophyte clones had unique alleles at 7 out of the 19 loci.In cluster analysis,Russian and Chinese gametophyte clones were separated into two different groups according to genetic distance.Overall,high genetic diversity was detected in gametophyte clones isolated from the two countries.These gametophyte cultures were believed to be appropriate parental materials for conducting breeding programs in the future.

  3. Notes on the discovery of Rafflesia hasseltii Suringar (Rafflesiaceae) in Taman Negara (National Park), Malaysia

    NARCIS (Netherlands)

    Latiff, A.; Mat-Salleh, K.

    2001-01-01

    Rafflesia hasseltii Suringar was discovered in the vicinity of Sungai Pelenting in Taman Negara, Pahang, with a population of about 20 buds and a few flowers in full bloom. This is the first confirmed report of the species for the National Park, Malaysia.

  4. William Harvey's epitaph.

    Science.gov (United States)

    Nutton, Vivian

    2003-05-01

    This paper gives the first published English translation of William Harvey's epitaph. The translation is based on a re-examination of the stone itself, and is accompanied by an explanatory commentary.

  5. [William Harvey revisited ].

    Science.gov (United States)

    Steinke, Hubert

    2015-07-01

    William Harvey's discovery of the circulation of the blood is often described as a product of the Scientific Revolution of the Seventeenth Century. Modern research has, however, shown thatHarvey followed the Aristotelian research tradition and thus tried to reveal the purpose of the organs through examination of various animals. His publication of 1628 has to be read as an argument of natural philosophy, or, more precisely, as a series of linked observations, experiments and philosophical reasonings from which the existence of circulation has to be deduced as a logical consequence. Harvey did not consider experiments as superior to philosophical reasoning nor intended he to create a new system of medicine. He believed in the vitality of the heart and the blood and rejected Francis Bacon's empirism and the mechanistic rationalism of Descartes. Harvey's contribution and originality lied less in his single observations and experiments but in the manner how he linked them with critical reasoning and how he accepted, presented and defended the ensuing radical findings.

  6. Om David Harvey

    DEFF Research Database (Denmark)

    Czeskleba-Dupont, Rolf; Schultz Jørgensen, Peter

    2015-01-01

    Harvey's geografiopfattelse præsenteres fra 'Explanation in Geography' (1969) til de seneste værker, hvor faget er hivet ud af elfenbenstårnet for at udgøre fundamentet til en 'people's geography'. Samtidigt er der sket en sammensmeltning af historisk og geografisk materialisme. Studier over...... 'kapitalen' gennemgås, hvor den geografiske dimension i kapitalens akkumulation er udarbejdet. Harvey's måde at videreføre Henri Lefebvre's tænkning om retten til byen bliver omtalt. Spørgsmålet rejses om arbejderklassen og byen. Og der fokuseres afsluttende på organisering af modstanden i et klassekamps-perspektiv....

  7. William Harvey, an Aristotelian anatomist.

    Science.gov (United States)

    Fara, Patricia

    2007-06-01

    William Harvey has long been celebrated as the founding father of physiology for refuting Galen and demonstrating that blood circulates round the body. Yet after his training at Padua, he became a committed Aristotelian: although strongly influencing the new observational sciences of the seventeenth century, Harvey himself looked back towards the classical past.

  8. William Harvey, Aristotle and astrology.

    Science.gov (United States)

    Gregory, Andrew

    2014-06-01

    In this paper I argue that William Harvey believed in a form of astrology. It has long been known that Harvey employed a macrocosm-microcosm analogy and used alchemical terminology in describing how the two types of blood change into one another. This paper then seeks to examine a further aspect of Harvey in relation to the magical tradition. There is an important corollary to this line of thought, however. This is that while Harvey does have a belief in astrology, it is strongly related to Aristotle's views in this area and is quite restricted and attenuated relative to some contemporary beliefs in astrology. This suggests a more general thesis. While Harvey was amenable to ideas which we associate with the natural magic tradition, those ideas had a very broad range of formulation and there was a limit to how far he would accept them. This limit was largely determined by Harvey's adherence to Aristotle's natural philosophy and his Christian beliefs. I argue that this is also the case in relation to Harvey's use of the macrocosm-microcosm analogy and of alchemical terminology, and, as far as we can rely on the evidence, this informs his attitudes towards witches as well. Understanding Harvey's influences and motives here is important in placing him properly in the context of early seventeenth-century thought.

  9. Harvey Cushing: Cushing's disease.

    Science.gov (United States)

    Ellis, Harold

    2012-09-01

    In 1932 Harvey Cushing published an article entitled 'Basophil adenomas of the pituitary and their clinical manifestations'. These are rare tumours of the anterior pituitary gland, at the base of the brain, with striking manifestations, which include adiposity of the face and trunk, but not the limbs, weakness, fatigue, abdominal striae, facial hair, high blood pressure and raised blood sugar. Although I spent two years in an army neurosurgical unit, I never saw a case. More frequently, the same clinical picture is produced by a benign adenoma of the suprarenal cortex, but today by far the commonest cause of this condition is seen in the patient receiving high dosage of cortisone, when we talk about the person exhibiting 'Cushingoid features'. Most readers of this journal will have seen such cases.

  10. Response to David Harvey.

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    Antonio Negri

    2011-01-01

    Full Text Available The text is a response of authors of Commonwealth to criticism presented by David Harvey. Hard and Negri turn down the primacy of class division over other various identity formations (e.g. race, gender and they perceive it as field of revolutionary struggle. Then, starting with Spinoza they highlight variety of definitions of singularity and do not agree withthe significant role ascribed to the notion of fictitious capital; they point out immaterial aspect of financialization and its role as a “central form of the accumulation of capital.” Finally, they emphasize the importance of recognition of present indignation and revolutionary actions, which could be made only from below.

  11. The Harvey lectures, Series 82

    Energy Technology Data Exchange (ETDEWEB)

    Botstein, D.; Cech, T.R.; Hille, B.; Lodish, H.F.; Majerus, P.W.

    1988-01-01

    The Harvey Lecture Series is published annually and provides reviews of research topics in the biomedical sciences. Eight lectures by investigators are included in the volume representing the most recent work in the major laboratories.

  12. Harvey Cushing's Canadian connections.

    Science.gov (United States)

    Feindel, William

    2003-01-01

    During his surgical career between 1896 and 1934, Harvey Cushing made eight visits to Canada. He had a broad impact on Canadian medicine and neurosurgery. Cushing's students Wilder Penfield and Kenneth McKenzie became outstanding leaders of the two major centers in Canada for neurosurgical treatment and training. On his first trip to Canada, shortly after completing his surgical internship in August 1896, Cushing traveled with members of his family through the Maritime Provinces and visited hospitals in Quebec and Montreal. Eight years later, in February 1904, as a successful young neurosurgeon at the Johns Hopkins Hospital, he reported to the Montreal Medico-Chirurgical Society on his surgical experience in 20 cases of removal of the trigeminal ganglion for neuralgia. In 1922, as the Charles Mickle Lecturer at the University of Toronto, Cushing assigned his honorarium of $1000 to support a neurosurgical fellowship at Harvard. This was awarded to McKenzie, then a general practitioner, for a year's training with Cushing in 1922-1923. McKenzie returned to initiate the neurosurgical services at the Toronto General Hospital, where he developed into a master surgeon and teacher. On Cushing's second visit to McGill University in October 1922, he and Sir Charles Sherrington inaugurated the new Biology Building of McGill's Medical School, marking the first stage of a Rockefeller-McGill program of modernization. In May 1929, Cushing attended the dedication of the Osler Library at McGill. In September 1934, responding to the invitation of Penfield, Cushing presented a Foundation Lecture-one of his finest addresses on the philosophy of neurosurgery-at the opening of the Montreal Neurological Institute. On that same trip, Cushing's revisit to McGill's Osler Library convinced him to turn over his own treasure of historical books to Yale University.

  13. Crataegus pinnatifida: Chemical Constituents, Pharmacology, and Potential Applications

    Directory of Open Access Journals (Sweden)

    Jiaqi Wu

    2014-01-01

    Full Text Available Crataegus pinnatifida (Hawthorn is widely distributed in China and has a long history of use as a traditional medicine. The fruit of C. pinnatifida has been used for the treatment of cardiodynia, hernia, dyspepsia, postpartum blood stasis, and hemafecia and thus increasing interest in this plant has emerged in recent years. Between 1966 and 2013, numerous articles have been published on the chemical constituents, pharmacology or pharmacologic effects and toxicology of C. pinnatifida. To review the pharmacologic advances and to discuss the potential perspective for future investigation, we have summarized the main literature findings of these publications. So far, over 150 compounds including flavonoids, triterpenoids, steroids, monoterpenoids, sesquiterpenoids, lignans, hydroxycinnamic acids, organic acids and nitrogen-containing compounds have been isolated and identified from C. pinnatifida. It has been found that these constituents and extracts of C. pinnatifida have broad pharmacological effects with low toxicity on, for example, the cardiovascular, digestive, and endocrine systems, and pathogenic microorganisms, supporting the view that C. pinnatifida has favorable therapeutic effects. Thus, although C. pinnatifida has already been widely used as pharmacological therapy, due to its various active compounds, further research is warranted to develop new drugs.

  14. Crataegus pinnatifida: chemical constituents, pharmacology, and potential applications.

    Science.gov (United States)

    Wu, Jiaqi; Peng, Wei; Qin, Rongxin; Zhou, Hong

    2014-01-30

    Crataegus pinnatifida (Hawthorn) is widely distributed in China and has a long history of use as a traditional medicine. The fruit of C. pinnatifida has been used for the treatment of cardiodynia, hernia, dyspepsia, postpartum blood stasis, and hemafecia and thus increasing interest in this plant has emerged in recent years. Between 1966 and 2013, numerous articles have been published on the chemical constituents, pharmacology or pharmacologic effects and toxicology of C. pinnatifida. To review the pharmacologic advances and to discuss the potential perspective for future investigation, we have summarized the main literature findings of these publications. So far, over 150 compounds including flavonoids, triterpenoids, steroids, monoterpenoids, sesquiterpenoids, lignans, hydroxycinnamic acids, organic acids and nitrogen-containing compounds have been isolated and identified from C. pinnatifida. It has been found that these constituents and extracts of C. pinnatifida have broad pharmacological effects with low toxicity on, for example, the cardiovascular, digestive, and endocrine systems, and pathogenic microorganisms, supporting the view that C. pinnatifida has favorable therapeutic effects. Thus, although C. pinnatifida has already been widely used as pharmacological therapy, due to its various active compounds, further research is warranted to develop new drugs.

  15. Complete Plastid Genome Sequence of the Brown Alga Undaria pinnatifida.

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    Lei Zhang

    Full Text Available In this study, we fully sequenced the circular plastid genome of a brown alga, Undaria pinnatifida. The genome is 130,383 base pairs (bp in size; it contains a large single-copy (LSC, 76,598 bp and a small single-copy region (SSC, 42,977 bp, separated by two inverted repeats (IRa and IRb: 5,404 bp. The genome contains 139 protein-coding, 28 tRNA, and 6 rRNA genes; none of these genes contains introns. Organization and gene contents of the U. pinnatifida plastid genome were similar to those of Saccharina japonica. There is a co-linear relationship between the plastid genome of U. pinnatifida and that of three previously sequenced large brown algal species. Phylogenetic analyses of 43 taxa based on 23 plastid protein-coding genes grouped all plastids into a red or green lineage. In the large brown algae branch, U. pinnatifida and S. japonica formed a sister clade with much closer relationship to Ectocarpus siliculosus than to Fucus vesiculosus. For the first time, the start codon ATT was identified in the plastid genome of large brown algae, in the atpA gene of U. pinnatifida. In addition, we found a gene-length change induced by a 3-bp repetitive DNA in ycf35 and ilvB genes of the U. pinnatifida plastid genome.

  16. Antioxidant activity of glycoprotein purified from Undaria pinnatifida measured by an in vitro digestion model.

    Science.gov (United States)

    Rafiquzzaman, S M; Kim, Eun-Young; Kim, Yu-Ri; Nam, Taek-Jeong; Kong, In-Soo

    2013-11-01

    The present study was performed to investigate the chemical composition and antioxidant activity of glycoprotein purified from Undaria pinnatifida Harvey (UPGP). On SDS-PAGE, UPGP migrated as a single band with a molecular weight of approximately 10 kDa and confirmed by staining with Schiff's reagent as glycoprotein. It consists of a carbohydrate component (42.53%) and protein component (57.47%). Amino acid profile, FT-IR spectrum and enzymatic glycosylation analysis suggested that protein is linked with carbohydrate by O-glycosylation. UPGP showed dose-dependent antioxidant activities as detected by different assays before and after in vitro digestion. The IC50 values of undigested UPGP were 0.25 ± 0.03, 0.08 ± 0.005, 0.69 ± 0.12, and 0.25 ± 0.08 mg/mL for DPPH, ABTS, FRAP, and NO, respectively. Following in vitro digestion, the antioxidant activities of UPGP were decreased during the gastric phase compared to those of undigested UPGP, with an increase occurring during the duodenal phase in all assays. However, the reducing power was unchanged after in vitro digestion. Furthermore, UPGP showed protective activity against oxidative DNA damage both undigested, after saliva and duodenal phase of digestion. These results indicate that the antioxidant and DNA protection activities of UPGP may be pH-dependent and assay specific.

  17. [Harvey and his theory of circulation].

    Science.gov (United States)

    Wolters, Frank J

    2013-01-01

    In 1628 the English physician William Harvey (1578-1657) published his revolutionary theory that blood circulates through the body driven by the heart. This challenged the long-standing teachings of Hippocrates and Galen concerning 4 different bodily fluids or 'humours' that flowed through separate arterial and venous vascular systems. Harvey gained considerable influence in society as a member of the prestigious Royal College of Physicians in London and as personal physician to King James I and King Charles I. He strove for a more empirical foundation of medicine by means of anatomic demonstrations and vivisections. Despite enduring considerable criticism he managed to disseminate his ideas around the influential universities of Europe in the course of his lifetime. However, consequent changes in practice would not be brought about until decades after Harvey's death, when Galenist treatments such as blood-letting were gradually abandoned.

  18. William Harvey, Peter Lauremberg and cardiac output.

    Science.gov (United States)

    Teichmann, G

    1992-11-01

    In 1636, the Rostock professor of medicine and the art of poetry, Peter Lauremberg (1585-1639), was one of the earliest to mention circulation which had been discovered by William Harvey and documented in his anatomical manual. In 1628 William Harvey proved the existence of the blood circulation by calculating the "cardiac output in a half an hour (semihora)". The answer to the question why Harvey chose half an hour as the time range can be found in the way of measuring time usual at that period. The sandglasses were turned half-hourly in maritime navigation and the wheel-clocks on shore had only the hour-hand. Improved chronometry was one of the prerequisites for measuring cardiac output. The minute-hand became usual after 1700 and the second-hand later on. Taking into consideration the alterations of cardiac output made the latter one of the most important circulation parameters in diagnostics, prognostication and therapeutics.

  19. Iain Harvey - inglasest võlur-produtsent / Iain Harvey ; interv. Heilika Võsu

    Index Scriptorium Estoniae

    Harvey, Iain

    2003-01-01

    Londoni animafilmistuudio "The Illuminated Film Company" produtsent Pimedate Ööde Filmifestivali animafilmide festivali "Animated Dreams 2002" külalisena. Lisatud andmed I. Harvey loomingulise tegevuse kohta, lk. 103

  20. Iain Harvey - inglasest võlur-produtsent / Iain Harvey ; interv. Heilika Võsu

    Index Scriptorium Estoniae

    Harvey, Iain

    2003-01-01

    Londoni animafilmistuudio "The Illuminated Film Company" produtsent Pimedate Ööde Filmifestivali animafilmide festivali "Animated Dreams 2002" külalisena. Lisatud andmed I. Harvey loomingulise tegevuse kohta, lk. 103

  1. La paradoja de Harvey-Descartes

    OpenAIRE

    González Recio, José Luis

    1995-01-01

    Tan Pronto Como El De Motu Cordis Fue Publicado, Descartes Acepto Eldescubrimiento De Harvey Sobre La Circulacion De La Sangre. La Teoria De Harveytenia Un Significado Mecanico Inequivoco, Aunque La Fuente Primaria Delmovimiento Del Corazon -Las Cualidades Esenciales De La Sangre- No Podia Serconsiderada Causa Real En Una Nueva Fisica Para La Que Tales Cualidades Debianser Expulsadas Del Lenguaje De La Ciencia. El Filosofo Frances Entendio Que Lafisica Era Reducible A La Mecanica Y Que El Cue...

  2. On a Conjecture of Harvey and Lawson

    OpenAIRE

    Wermer, John

    2008-01-01

    We consider complex projective space P^{n} and a smooth closed curve gamma in P^{n}. Harvey and Lawson have defined the notion of the projective hull \\hat{K} of a compact subset K in P^n. This concept is an analogue of the polynomial hull of compact subsets of C^{n}. In the present note we study the relation between the following two properties of the curve gamma: (1) \\hat{gamma} - gamma is a one-dimensional complex analytic subvariety of P^{n} - gamma, and (2) There exists a Stein subdomain ...

  3. Who killed HIV/AIDS activist Steve Harvey?

    Science.gov (United States)

    Mullins, Garry

    2006-04-01

    On 30 November 2005, Jamaican HIV/AIDS activist Steve Harvey was found murdered. Harvey was a staunch defender of the human rights of people living with, and vulnerable to, HIV/AIDS. Since 1997, he had worked at Jamaica AIDS Support. In this commentary, Garry Mullins examines the deep roots and social acceptance of homophobia, and its consequences, in Jamaican society.

  4. Harvey Butcher: a passion for astronomical instrumentation

    Science.gov (United States)

    Bhathal, Ragbir

    2014-11-01

    This paper covers some aspects of the scientific life of Harvey Butcher who was the Director of the Research School for Astronomy and Astrophysics at the Australian National University in Canberra from September 2007 to January 2013. He has made significant contributions to research on the evolution of galaxies, nucleosynthesis, and on the design and implementation of advanced astronomical instrumentation including LOFAR (Low Frequency Array Radio telescope). He is well known for his discovery of the Butcher-Oemler effect. Before coming to Australia he was the Director of the Netherlands Foundation for Research in Astronomy from September 1991 to January 2007. In 2005 he was awarded a Knighthood in the Order of the Netherlands Lion for contributions to interdisciplinary science, innovation and public outreach.This paper is based on an interview conducted by the author with Harvey Butcher for the National Project on Significant Australian Astronomers sponsored by the National Library of Australia. Except otherwise stated, all quotations used in this paper are from the Butcher interview which has been deposited in the Oral History Archives of the National Library.

  5. Potential Use of Polysaccharides from the Brown Alga Undaria pinnatifida as Anticoagulants

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    Caterina Faggio

    2015-10-01

    Full Text Available Undaria pinnatifida (U. pinnatifida is a highly invasive species and has caused concern all over the world because it has invaded coastal environments, has the potential to displace native species, significantly alters habitat for associated fauna, and disturbs navigation. Any attempt to eradicate it would be futile, owing to the elusive, microscopic gametophyte, and because the alga thrives in sites rich in anthropic activities. Venice Lagoon is the largest Mediterranean transitional environment and the spot of the highest introduction of non-indigenous species, including U. pinnatifida, which is removed as a waste. We demonstrated that polysaccharide extracts from U. pinnatifida have an anticoagulant effect on human blood in vitro and are not cytotoxic. The results obtained by PT (normal values 70-120% and APTT (normal values 28-40s assays were significantly prolonged by the polysaccharide extracts of U. pinnatifida, therefore algal extracts are ideal candidates as antithrombotic agents.

  6. Harvey, by Hercules! The hero of the blood's circulation.

    Science.gov (United States)

    O'Rourke Boyle, Marjorie

    2013-01-01

    This article continues the analyses in Medical History 52 (2008), 73-90, 365-86 of William Harvey's self-understanding as the philosopher and discoverer of the blood's circulation. Harvey brilliantly and subversively assumed the persona of the mythological Hercules to embody his own anatomical labour in De motu cordis et sanguinis (1628). He reprised the role in self-defence against accusations in the College of Physicians, London, of his breach of faith with medical tradition. Harvey sought to usurp the medical epithet 'a second Hercules' by reforming humanist dependence on ancient texts as authoritative medicine. A knowledge of the theory and practice of Renaissance humanism discloses his identification with the Herculean labour of cleansing the Augean stable. He employed anatomical demonstration against Galen's porous cardiac septum, which admitted blood across the ventricles. Harvey's oath mehercule swore against Galen's Dia to assert the necessity of opening an alternate route for the blood flow. His Herculean labour was to dam the cardiac septum and divert the blood flow into a continuous channel through the arteries and veins. His circulation of the blood also imitated Hercules' successful dependence on the force of the water flow to flush the Augean stable. Harvey's copia did not denote a quantitative amount but a powerful supply. Harvey aspired to be, like Hercules, immortal, a term which the College belatedly acknowledged. This cultural analysis exposes Harvey's professional issues and personal ambitions, so to promote a fuller understanding of his historic role in medical discovery.

  7. [William Harvey, discoverer of the blood circulation].

    Science.gov (United States)

    v Mühlendahl, K E

    2007-06-01

    William Harvey (1578-1657), living at the turn to modern times, scientifically speaking, was an eminent physician and scientist. He developed the concept of the circulation of the blood and his findings have proved to be correct in nearly all details to this day. He published his physiological findings and interpretations in a small, albeit epoch-making, volume: Exercitatio anatomica de motu cordis et sanguinis in animalibus, published in Frankfurt in 1628. On the occasion of the 350th anniversary of his death on June 3, 2007, this essay commemorates the work of this important physician, illustrating his brilliant conception of the blood circulation by quoting passages from De motu cordis et sanguinis.

  8. LAS GRIETAS DE LA CIUDAD CAPITALISTA Entrevista con David Harvey

    OpenAIRE

    Rendueles, César; del Olmo, Carolina

    2011-01-01

    David Harvey es uno de los investigadores de la ciudad capitalista más renombrados de la actualidad. Geógrafo de formación, Harvey ha desarrollado el grueso de su carrera profesional en Estados Unidos, donde actualmente enseña Geografía y Estudios Urbanos en City University of New York tras haber sido durante más de treinta años profesor en la Johns Hopkins University de Baltimore. El principal e indiscutido mérito de la obra de Harvey reside en su fructífera fusión de geografía y marxismo co...

  9. Antioxidant Properties of Phenolic Compounds in Renewable Parts of Crataegus pinnatifida inferred from Seasonal Variations.

    Science.gov (United States)

    Luo, Meng; Yang, Xuan; Hu, Jiao-Yang; Jiao, Jiao; Mu, Fan-Song; Song, Zhuo-Yue; Gai, Qing-Yan; Qiao, Qi; Ruan, Xin; Fu, Yu-Jie

    2016-05-01

    In this study, the effect of seasonal variations on Crataegus pinnatifida, changes in antioxidant activity and active components in C. pinnatifida leaves, roots, twigs, and fruits from May to October were investigated. Through correlation analysis of climatic factors and 7 phenolic compounds yield, the phenolic compounds content was positively correlated with temperatures and daytime. The correlation coefficient of temperatures and daytime were 0.912 and 0.829, respectively. 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, 2,2'-azino-bis 3-ethylbenzothiazoline-6-sulphonic acid (ABTS) radical scavenging and reducing power tests were employed to evaluate the antioxidant activity of the C. pinnatifida. C. pinnatifida leaves exhibited significant advantages in terms of higher phenolic contents and excellent antioxidant activities. Principal component analysis (PCA) revealed that 2 main PC characterize the C. pinnatifida phenolic composition (82.1% of all variance). C. pinnatifida leaves in September possessed remarkable antioxidant activity. The results elucidate that C. pinnatifida leaves, as renewable parts, are suitable for application as antioxidant ingredients.

  10. In vitro antidiabetic potential of the fruits of Crataegus pinnatifida.

    Science.gov (United States)

    Chowdhury, S S; Islam, M N; Jung, H A; Choi, J S

    2014-01-01

    In an attempt to develop alternative medicine for the treatment of diabetes and related complications, the antidiabetic potential of the fruits of Crataegus pinnatifida was evaluated. The antidiabetic potential of the methanol (MeOH) extract as well as different solvent soluble fractions of the fruits of C. pinnatifida was evaluated via α-glucosidase, protein tyrosine phosphatase 1B (PTP1B), rat lens aldose reductase (RLAR), and advanced glycation end products (AGEs) formation inhibitory assays. The MeOH extract showed potent inhibitory activity against α-glucosidase, PTP1B, and AGEs formation with IC50 values of 122.11, 3.66 and 65.83 μg/ml respectively, while it showed moderate inhibitory activity against RLAR with the IC50 value of 160.54 μg/ml. Among different fractions, the ethyl acetate (EtOAc) and the dichloromethane (CH2Cl2) fractions were found as active fractions exhibiting potential α-glucosidase, PTP1B, RLAR inhibitory, and AGEs formation inhibitory activities. Seven compounds including hyperoside, chlorogenic acid, ursolic acid, oleanolic acid, 3-epicorosolic acid, β-sitosterol, β-sitosterol glucoside were isolated from these two fractions. 3-Epicorosolic acid showed both potent α-glucosidase and PTP1B inhibitory activities with IC50 values of 30.18 and 4.08 μg/ml respectively. Moreover, kinetic study revealed that 3-epicorosolic acid showed mixed type inhibition against PTP1B, while it showed uncompetitive inhibition against α-glucosidase. Therefore, these results suggest that the fruits of C. pinnatifida and its constituents have potential antidiabetic activity which might be used as a functional food for the treatment of diabetes and associated complications.

  11. Micropropagation of Kalanchoe tubiflora (Harvey Hamet

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    Dariusz Kulus

    2015-03-01

    Full Text Available Kalanchoe tubiflora (Harvey Hamet is a succulent plant native to Madagascar. Due to its unique morphology, it is a popular ornamental species. However, owing to some valuable metabolites it can also be used in tumor suppression. The present work describes a simple propagation method of K. tubiflora. The stem fragments of K. tubiflora were disinfected with the following sodium hypochlorite concentrations: 0.2% (for 10 or 20 min, 0.4% (10 or 20 min and 0.6% (10 or 20 min. Next the single-node explants were inoculated on a hormone-free MS medium. The produced plants were transferred to soil and grown in a greenhouse. The applied disinfection procedures were successful. The regeneration of propagules was observed. The average number of new microshoots produced from one explant varied from about 20 to even 52. All microshoots regenerated adventitious roots without transferring them to a rooting medium. The plantlets were successfully acclimatized and continued their growth in the greenhouse.

  12. 75 FR 39632 - Regulated Navigation Area; Gulf Intracoastal Waterway, Inner Harbor Navigation Canal, Harvey...

    Science.gov (United States)

    2010-07-12

    ..., Inner Harbor Navigation Canal, Harvey Canal, Algiers Canal, New Orleans, LA; Correction ACTION: Interim... Navigation Canal, Harvey Canal, Algiers Canal, New Orleans, LA into the Code of Federal Regulations....

  13. Two new compounds from Crataegus pinnatifida and their antithrombotic activities.

    Science.gov (United States)

    Zhou, Chen-Chen; Huang, Xiao-Xiao; Gao, Pin-Yi; Li, Fei-Fei; Li, Dian-Ming; Li, Ling-Zhi; Song, Shao-Jiang

    2014-01-01

    One new sesquiterpene, (1α,4aβ,8aα)-1-isopropanol-4a-methyl-8-methylenedecahydronaphthalene (1), with one new phenylpropanoid, threo-2-(4-hydroxy-3,5-dimethoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-3-ethoxypropan-1-ol (2), along with four known phenylpropanoids were isolated from Crataegus pinnatifida. The structures of compounds 1 and 2 were elucidated on the basis of 1D, 2D NMR analyses, and HR-ESI-MS. The antithrombotic activity in vitro of all isolates was assayed, and only compound 1 exhibited potent antithrombotic activity by inhibiting platelet aggregation in rat plasma by 81.4% at 1 mg/ml.

  14. Isolation of cytotoxic compounds from the seeds of Crataegus pinnatifida.

    Science.gov (United States)

    Li, Ling-Zhi; Peng, Ying; Niu, Chao; Gao, Pin-Yi; Huang, Xiao-Xiao; Mao, Xin-Liang; Song, Shao-Jiang

    2013-07-01

    To study the chemical constituents and bioactivity of the seeds of Crataegus pinnatifida. The chemical constituents were isolated and purified by macroporous adsorptive resin D101, silica gel, and ODS column chromatography, and preparative HPLC. Their structures were elucidated on the basis of spectroscopic methods. In addition, the cytotoxic activities of compounds 1-4 were investigated on OPM2 and RPMI-8226 cells. Four compounds were obtained and their structures were identified as (7S, 8S)-4-[2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-(hydroxymethyl)ethoxy]-3, 5-dimethoxybenzaldehyde (1), (+)-balanophonin (2), erythro-guaiacylglycerol-β-coniferyl aldehyde ether (3), buddlenol A (4). Compound 1 is a novel norlignan, while compounds 1-4 exhibited marginal inhibition on the proliferation of OPM2 and RPMI-8226 cells. Copyright © 2013 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.

  15. Isolation of Protoplasts from Undaria pinnatifida by Alginate Lyase Digestion

    Institute of Scientific and Technical Information of China (English)

    HU Xiaoke; JIANG Xiaolu; GUAN Huashi

    2003-01-01

    The aim of this study is to isolate protoplasts from Undaria pinnatifida. Protoplasts of the alga were isolated enzymatically by using alginate lyase, which was prepared by fermenting culture of a strain Vibrio sp. 510. Monofacterial method was applied for optimizing digestion condition. The optimum condition for protoplast preparation is enzymatic digestion at 28 ℃ for 2 h using alginate lyase at the concentration of 213.36 U (8 mL) every 0.5 g fresh thalline with NaCl 50 and at the shaking speed of 150 r min-1 during digestion. The protoplast yield can reach 2.62 + 0.09 million per 0.5 g fresh leave under the optimum condition. The enzyme activity is inhibited by Ca2+ and slightly enhanced by Fe2+ and Mn2+ at concentrations of 0.05, 0.08 and 0.10 molL-1.

  16. 75 FR 32275 - Regulated Navigation Area; Gulf Intracoastal Waterway, Inner Harbor Navigation Canal, Harvey...

    Science.gov (United States)

    2010-06-08

    ...), Harvey Canal, and Algiers Canal during severe hurricane conditions. Vessels will not be permitted to stay... Harbor Navigation Canal, Harvey Canal, and Algiers Canal during severe hurricane conditions. Those..., Inner Harbor Navigation Canal, Harvey Canal, Algiers Canal, New Orleans, LA AGENCY: Coast Guard, DHS...

  17. Hair growth activity of Crataegus pinnatifida on C57BL/6 mouse model.

    Science.gov (United States)

    Shin, Heon-Sub; Lee, Jung-Min; Park, Sang-Yong; Yang, Jung-Eun; Kim, Ju-Han; Yi, Tae-Hoo

    2013-09-01

    Crataegus pinnatifida has a long history of use in traditional oriental herbal medicine to stimulating digestion and improving blood circulation. Based on nutrition of hair, the present study was conducted to assess the effect of C. pinnatifida extract on hair growth using mouse model and its mechanisms of action. The C. pinnatifida extract containing the contents of total polyphenol of 5.88□0.82 g gallic acid/100 g extract and proanthocyanidin of 9.15□1.58 mg cyaniding chloride/100 g extract was orally administered daily at a dosage of 50 mg/kg weight to the 7-week-old C57BL/6 mice in telogen. The C. pinnatifida extract promoted hair growth by inducing anagen phase in mice in telogen, reflected by color of skin, thickness of hair shaft, and density of hair. The ratio of anagento telogen was determined by shape of hair follicles in vertically sectioned slide and increased by oral administration of C. pinnatifida extract. The number and the size of hair follicles were also enlarged, indicating anagen phase induction. The proliferation of human dermal papilla cells (hDPC) was accelerated by addition of C. pinnatifida extract, which activated the signaling of mitogen-activated protein kinases (Erk, p-38, and JNK) and Akt. Moreover, the ratio of Bcl-2/Bax as the determinant of cell fate was also raised in skin. These results suggest that the C. pinnatifida extract promotes hair growth by inducing anagen phase, which might be mediated by the activation of cellular signalings that enhance the survival of cultured hDPC and the increase of the ratio of Bcl-2 to Bax that protects cells against cell death. Copyright © 2012 John Wiley & Sons, Ltd.

  18. Abundance and recruitment data for Undaria pinnatifida in Brest harbour, France: Model versus field results

    Directory of Open Access Journals (Sweden)

    James T. Murphy

    2016-06-01

    Full Text Available The data presented in this article are related to the research article entitled “A modelling approach to explore the critical environmental parameters influencing the growth and establishment of the invasive seaweed Undaria pinnatifida in Europe” [1]. This article describes raw simulation data output from a novel individual-based model of the invasive kelp species Undaria pinnatifida. It also includes field data of monthly abundance and recruitment values for a population of invasive U. pinnatifida (in Brest harbour, France that were used to validate the model. The raw model output and field data are made publicly available in order to enable critical analysis of the model predictions and to inform future modelling efforts of the study species.

  19. Polyphenolic Profile and Biological Activity of Chinese Hawthorn (Crataegus pinnatifida BUNGE Fruits

    Directory of Open Access Journals (Sweden)

    Tunde Jurikova

    2012-12-01

    Full Text Available Chinese hawthorn (Crataegus pinnatifida Bge. fruits are rich in polyphenols (e.g., epicatechin, procyanidin B2, procyanidin B5, procyanidin C1, hyperoside, isoquercitrin and chlorogenic acid—active compounds that exert beneficial effects. This review summarizes all information available on polyphenolic content and methods for their quantification in Chinese hawthorn berries and the relationships between individual polyphenolic compounds as well. The influence of species or cultivars, the locality of cultivation, the stage of maturity, and extract preparation conditions on the polyphenolic content were discussed as well. Currently, only fruits of C. pinnatifida and C. pinnatifida var. major are included in the Chinese Pharmacopoeia. Recent trials have demonstrated the efficacy of Chinese hawthorn fruit in lowering blood cholesterol and the risk of cardiovascular diseases. The fruit has also demonstrated anti-inflammatory and anti-tumour activities. This review deals mainly with the biological activity of the fruit related to its antioxidant properties.

  20. Polyphenolic profile and biological activity of Chinese hawthorn (Crataegus pinnatifida BUNGE) fruits.

    Science.gov (United States)

    Jurikova, Tunde; Sochor, Jiri; Rop, Otakar; Mlcek, Jiri; Balla, Stefan; Szekeres, Ladislav; Adam, Vojtech; Kizek, Rene

    2012-12-06

    Chinese hawthorn (Crataegus pinnatifida Bge.) fruits are rich in polyphenols (e.g., epicatechin, procyanidin B2, procyanidin B5, procyanidin C1, hyperoside, isoquercitrin and chlorogenic acid)--active compounds that exert beneficial effects. This review summarizes all information available on polyphenolic content and methods for their quantification in Chinese hawthorn berries and the relationships between individual polyphenolic compounds as well. The influence of species or cultivars, the locality of cultivation, the stage of maturity, and extract preparation conditions on the polyphenolic content were discussed as well. Currently, only fruits of C. pinnatifida and C. pinnatifida var. major are included in the Chinese Pharmacopoeia. Recent trials have demonstrated the efficacy of Chinese hawthorn fruit in lowering blood cholesterol and the risk of cardiovascular diseases. The fruit has also demonstrated anti-inflammatory and anti-tumour activities. This review deals mainly with the biological activity of the fruit related to its antioxidant properties.

  1. Differences in the removal mechanisms of Undaria pinnatifida and Phragmites australis as biomaterials for lead removal.

    Science.gov (United States)

    Soto-Rios, Paula Cecilia; Nakano, Kazunori; Leon-Romero, Marco; Aikawa, Yoshio; Arai, Shigeyuki; Nishimura, Osamu

    2015-01-01

    This study offers the opportunity to utilize Undaria pinnatifida and Phragmites australis to remove lead from water in permeable reactive barrier (PRB) technology. Its efficacy was tested using batch experiments and PRB column systems. From the batch experiment results, a higher adsorption capacity was observed for Undaria pinnatifida. Nevertheless, Phragmites australis in the column system efficiently removed lead and the breakthrough occurred at the same time for both biomaterials. To dissipate this difference, a sequential extraction for metal speciation analysis was used for both columns. The results have shown that each biomaterial has a dominant mechanism. Phragmites australis removed lead by physical adsorption, whereas Undaria pinnatifida showed a higher tendency to bind lead due to organic matter, primary and secondary minerals.

  2. Abundance and recruitment data for Undaria pinnatifida in Brest harbour, France: Model versus field results.

    Science.gov (United States)

    Murphy, James T; Voisin, Marie; Johnson, Mark; Viard, Frédérique

    2016-06-01

    The data presented in this article are related to the research article entitled "A modelling approach to explore the critical environmental parameters influencing the growth and establishment of the invasive seaweed Undaria pinnatifida in Europe" [1]. This article describes raw simulation data output from a novel individual-based model of the invasive kelp species Undaria pinnatifida. It also includes field data of monthly abundance and recruitment values for a population of invasive U. pinnatifida (in Brest harbour, France) that were used to validate the model. The raw model output and field data are made publicly available in order to enable critical analysis of the model predictions and to inform future modelling efforts of the study species.

  3. [William Harvey and the beginnings of modern medical science].

    Science.gov (United States)

    de Micheli, Alfredo

    2005-01-01

    Modern medical science was born in the post-Renaissance age and began to consolidate towards the middle of the XVII century thanks to physicists, physiologists, and biologists, most of whom were direct or indirect pupils, of Galilei. The discovery of blood circulation by Harvey is now considered the only progress in physiology at the beginning of the XVII century, comparable to the current advances seen in physical sciences. The history of this achievement could be written from the view point of the progressive advance in knowledge. In his experiments, Harvey referred to the authentic, not the imaginary experiments, and put forward irrefutable quantitative arguments. We can therefore claim that his discovery of blood circulation was the first proper explanation of an organic process and the starting point leading to experimental physiology. Nevertheless, the second monograph of the English researcher, dealing with the generation of animals, published in 1651, has some passages that correspond to modern scientific reasoning yet in others he includes confused, vague and capricious assertions compatible with the prescientific era that the author was not able to escape completely. In conclusion, it seems justified to assert that modern medical science did not all rise suddenly, but was gradually structured starting from the middle of the XVII century following the path traced by William Harvey in light of Galilei's thought.

  4. Discovery of the cardiovascular system: from Galen to William Harvey.

    Science.gov (United States)

    Aird, W C

    2011-07-01

    The goal of this review is to examine the events that led to discovery of blood circulation. The Ancient Greeks, including Hippocrates and Galen viewed the cardiovascular system as comprising two distinct networks of arteries and veins. Galen claimed that the liver produced blood that was then distributed to the body in a centrifugal manner, whereas air or pneuma was absorbed from the lung into the pulmonary veins and carried by arteries to the various tissues of the body. Arteries also contained blood, which passed from the venous side via invisible pores in the interventricular septum and peripheral anastomoses. This was an open-ended system in which blood and air simply dissipated at the ends of veins and arteries according to the needs of the local tissue. Blood was not seen to circulate but rather to slowly ebb and flow. This view would hold sway for 15 centuries until 1628 when William Harvey published his momentous 72-page book, On the Motion of the Heart and Blood in Animals. Harvey employed experiment and deductive logic to show that arteries and veins are functionally, if not structurally, connected in the lung and the peripheral tissues, and that blood circulates. The mechanical force of the heart replaced Galen's elusive attractive powers. Ultimately, Galenism would collapse under the weight of Harvey's evidence, and a new paradigm of blood circulation would prevail.

  5. The invasive kelp Undaria pinnatifida (Laminariales, Ochrophyta) along the north coast of Portugal: distribution model versus field observations.

    Science.gov (United States)

    Veiga, P; Torres, A C; Rubal, M; Troncoso, J; Sousa-Pinto, I

    2014-07-15

    After the first report of Undaria pinnatifida in north Portugal (between 1999 and 2007), a rapid spread of this species could be expected due to the presence of a stable population and the favourable environmental conditions proposed by distribution models. However, field surveys showed that U. pinnatifida was not present in most of the rocky shores in north Portugal. It seems that U. pinnatifida cannot outcompete native species outside of marinas in north Portugal. The only population in natural rocky shores was found in Buarcos, where this species was frequent. This study provides density data of U. pinnatifida that will be useful in the future to monitor changes on its abundance and distribution in the centre and south of Portugal.

  6. "Meam de motu & usu cordis, & circuitu sanguinis sententiam": teleology in William Harvey's De motu cordis.

    Science.gov (United States)

    Distelzweig, Peter

    2014-01-01

    I describe the place of teleology in William Harvey's understanding of anatomy, drawing especially on his lecture and working notes from (roughly) the decade leading up to the publication of De motu cordis. Harvey understands the goal of anatomy to be universal, final causal knowledge of the parts of animals and their variations, articulated in terms of their actiones and usus. I then carefully trace the role of teleology in the De motu cordis, distinguishing (with Harvey) between his opinion "de motu & usu cordis" and "de circuitu sanguinis". I argue that in the De motu cordis Harvey provides teleological explanations of features of the heart and arteries and their variations in terms of the circulation of the blood, understood as the actio of the heart. In this way the De motu cordis clearly embodies Harvey's understanding of the teleological character of anatomical knowledge.

  7. 33 CFR 334.412 - Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area.

    Science.gov (United States)

    2010-07-01

    ..., Harvey Point and adjacent waters, NC; restricted area. 334.412 Section 334.412 Navigation and Navigable... REGULATIONS § 334.412 Albemarle Sound, Pamlico Sound, Harvey Point and adjacent waters, NC; restricted area. (a) The area. Beginning on the north shore of Albemarle Sound and the easternmost tip of Harvey...

  8. Do native grazers from Patagonia, Argentina, consume the invasive kelp Undaria pinnatifida? ¿Pueden los pastoreadores nativos de Patagonia, Argentina, consumir al alga invasora Undaria pinnatifida?

    Directory of Open Access Journals (Sweden)

    S. Valeria Teso

    2009-06-01

    Full Text Available The invasive kelp Undaria pinnatifida (Phaeophyceae, Laminariales was first reported in Golfo Nuevo in 1992 and since then it has spread widely over more than 170 km, all along the northern Patagonian coast, Argentina. Field observations in the region have indicated the potential role of invertebrate grazers, like the sea urchins Arbacia dufresnii and Pseudechinus magellanicus and the gastropod Tegula patagonica, in controlling algal density. Laboratory experiments were conducted to ascertain whether, and if so, to what extent these grazers actually feed on the algae. The studied sea urchins fed on the alga, whereas the snail scraped off biofouling adhered to its surface. Higher densities of grazers were observed on the kelp during summer and might be attributed to increasing in metabolism with increasing temperature, and degradation of blades and sporophylls, which possibly increase their palatability.El alga invasora Undaria pinnatifida (Phaeophyceae, Laminariales fue reportada por primera vez en Golfo Nuevo en 1992, dispersándose ampliamente a lo largo de 170 km de costa en el norte de la Patagonia, Argentina. Observaciones de campo hechas en los erizos de mar Arbacia dufresnii y Pseudechinus magellanicus y en el gasterópodo Tegula patagonica evidenciaron que son posibles consumidores de Undaria pinnatifida en la población local. Se realizaron experimentos de laboratorio con el objetivo de probar si estos pastoreadores eran capaces de consumir el alga. Los erizos de mar estudiados consumen el alga, mientras que el gasterópodo ramonea los epibiontes presentes sobre su superficie. Altas densidades de ramoneadores fueron encontradas sobre el alga durante el verano y podrían ser atribuidas a un aumento del su metabolismo con el aumento de la temperatura y a la degradación de las láminas y esporofilos, lo cual posiblemente aumente la palatabilidad del alga.

  9. Anticancer potential and content of fucoidan extracted from sporophyll of New Zealand Undaria pinnatifida

    Directory of Open Access Journals (Sweden)

    Wilfred eMak

    2014-07-01

    Full Text Available Undaria pinnatifida is a species of brown seaweed known to contain rich amounts of fucoidan, a sulphated polysaccharide known to possess various biological activities. We isolated crude fucoidan (F0 from the sporophylls of U. pinnatifida grown in the Marlborough Sounds, New Zealand. Sulphate content, uronic acid content and molecular weight of F0 were 15.02%, 1.24% and >150 kDa, respectively. F0 was fractionated to yield three further fractions: F1, F2 and F3. Cytotoxicity of two major fractions was determined by the 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT assay. The algal fucoidans specifically suppressed the proliferation of three cancer cell lines with less cytotoxicity against the normal cells. Selective cytotoxicity could relate to the distinctive structures of each fucoidan fraction. Results from this study provide evidence that fucoidan, especially from U. pinnatifida grown in New Zealand, possesses great potential to be used as a functional food to reduce cancer risk or supplement cancer treatment.

  10. William Harvey and the discovery of the circulation of the blood

    Directory of Open Access Journals (Sweden)

    Ribatti Domenico

    2009-09-01

    Full Text Available Abstract This Commentary emphasizes the fundamental contribution of William Harvey to the discovery of the circulation of the blood and his scientific and experimental approach to this matter.

  11. The Legacies of Literacy: From Plato to Freire through Harvey Graff.

    Science.gov (United States)

    Gee, James Paul

    1989-01-01

    Reviews "The Legacies of Literacy: Continuities and Contradictions in Western Culture and Society" (Harvey G. Graff). Discusses the historical role of literacy education as a tool for liberation, emphasizing the viewpoints of Plato and Freire. (FMW)

  12. "Highly qualified loser"? Harvey Cushing and the Nobel Prize.

    Science.gov (United States)

    Hansson, Nils; Schlich, Thomas

    2015-04-01

    Neurosurgery, in particular surgery of the brain, was recognized as one of the most spectacular transgressions of the traditional limits of surgical work. With their audacious, technically demanding, laboratory-based, and highly promising new interventions, prominent neurosurgeons were primary candidates for the Nobel Prize. Accordingly, neurosurgical pioneers such as Victor Horsley and, in particular, Harvey Cushing continued to be nominated for the prize. However, only António Egas Moniz was eventually awarded the prestigious award in 1949 for the introduction of frontal lobotomy, an intervention that would no longer be prize-worthy from today's perspective. Horsley and Cushing, who were arguably the most important proponents of early neurosurgery, remained "highly qualified losers," as such cases have been called. This paper examines the nominations, reviews, and discussions kept in the Nobel Archives to understand the reasons for this remarkable choice. At a more general level, the authors use the example of neurosurgery to explore the mechanisms of scientific recognition and what could be called the enacting of excellence in science and medicine.

  13. Harvey Cushing's ghosts: death and hauntings in modern medicine.

    Science.gov (United States)

    Shin, Paul

    2011-06-01

    The passing of Yale School of Medicine's 2010 Bicentennial occasions a moment of reflecting on the past, present, and future of medical education and research at Yale and beyond. Last June, a ribbon-cutting ceremony inaugurated the opening of the Cushing Center in the Cushing-Whitney Medical Library. Named after Harvey Cushing, an early 20th-century neurosurgeon and former Yale College alum, the dual education/exhibition space now houses hundreds of gross brain specimens constituting the Cushing Tumor Registry. Originally a personal collection, Cushing donated his numerous medical specimens, photographs, and other medical relics from his deathbed, relinquishing the brains to Yale only under the condition that a suitable space be erected to preserve the many specimens. Some 70 years later and after nearly being destroyed, Cushing's wish is fully realized: The once desiccated, hidden brains have been painstakingly restored and are now on view in the Cushing Center. The brains express Cushing's singular and spectral worldview as a surgeon, artist, athlete, soldier, book collector, and historian.

  14. New data about optic properties of biominerals from some brown algae Undaria pinnatifida and Laminaria japonica

    Science.gov (United States)

    Pamirsky, I. E.; Chung, G.; Gutnikov, S. A.; Golokhvast, K. S.

    2016-11-01

    For the first time we made an attempt to study morphological types of phytoliths in the same species of multicellular brown algae (Undaria pinnatifida, Laminaria japonica) growing in different locations. However, in all samples only shapeless silicon dioxide particles were found. Some of them had rough edges, the other had smooth edges. We assume that the rough-edged shapeless phytolithes were formed within cells and smooth-edged - in the intercellular space. Verification of this assumption needs confirmation by detection of similar structures in the tissues of live algae.

  15. [The unfolding of the blood circulation doctrine: the correspondence between William Harvey and Caspar Hofmann in May 1636].

    Science.gov (United States)

    Rebollo, Regina André

    2002-01-01

    The present article analyzes the letters exchanged by Caspar Hofmann and William Harvey in 1636 and the delineation of the main questions and answers on the blood circulation theory. The first part of the article presents concepts about blood circulation according to the time's physiology; the second part presents the changes introduced by Harvey; the third and last part presents the debate between Hofmann and Harvey.

  16. Two New C-glucoside Flavonoids from Leaves of Crataegus pinnatifida Bge.var.major N.E.Br.

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Two new C-glucoside flavonoids,namely 8-C-(-D-(2(-O-acetyl) glucofuranosyl apigenin and 3(-O-acetylvitexin,were isolated from leaves of Crataegus pinnatifida Bge.var.major N.E.Br..Their structures were elucidated by the spectroscopic means and chemical evidence.

  17. Phenolic contents and cellular antioxidant activity of Chinese hawthorn "Crataegus pinnatifida".

    Science.gov (United States)

    Wen, Lingrong; Guo, Xingbo; Liu, Rui Hai; You, Lijun; Abbasi, Arshad Mehmood; Fu, Xiong

    2015-11-01

    It is evident from various epidemiological studies that consumption of fruits and vegetables is essential to maintain health and in the disease prevention. Present study was designed to examine phenolic contents and antioxidant properties of three varieties of Crataegus pinnatifida (Chinese hawthorn). Shanlihong variety exhibited elevated levels of total phenolics and flavonoid contents, including free and bond phenolics. Procyanidin B2 was most abundant phenolic compound in all samples, followed by epicatechin, chlorogenic acid, hyperoside, and isoquercitrin. The free ORAC values, and free hydro-PSC values were 398.3-555.8 μmol TE/g DW, and 299.1-370.9 μmol VCE/g DW, respectively. Moreover, the free cellular antioxidant activity (CAA) values were 678-1200 μmol of QE/100 g DW in the no PBS wash protocol, and 345.9-532.9 μmol of QE/100 g DW in the PBS wash protocol. C. pinnatifida fruit could be valuable to promote consumer health. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Antioxidant and tyrosinase inhibitory effects of neolignan glycosides from Crataegus pinnatifida seeds.

    Science.gov (United States)

    Huang, Xiao-Xiao; Liu, Qing-Bo; Wu, Jie; Yu, Li-Hong; Cong, Qian; Zhang, Yan; Lou, Li-Li; Li, Ling-Zhi; Song, Shao-Jiang

    2014-12-01

    In our efforts to find an inhibitor of melanin formation and develop potential depigmenting agents for skin-protecting cosmetics and medicinal products from natural resources, we focused on the seeds of Crataegus pinnatifida which showed antioxidant and tyrosinase-inhibiting activities. By activity-guided fractionation of an extract of C. pinnatifida seeds, four new neolignan glycosides, pinnatifidaninsides A-D (1-4), along with two known compounds (5-6), were isolated. Their structures were elucidated by spectroscopic analyses, especially 1D, 2D NMR and CD spectra. The antioxidant and tyrosinase-inhibiting activities of all isolates were assayed. Compound 6 showed good activity against 2,2-diphenyl-1-pikrylhydrazyl, while compounds 1, 2, 5, and 6 exhibited strong 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) free radical scavenging activity, being as effective as, or even more effective than the positive control Trolox. Moreover, compounds 5 and 6 displayed a moderate mushroom tyrosinase inhibitory activity. Georg Thieme Verlag KG Stuttgart · New York.

  19. HPLC determination of eight polyphenols in the leaves of Crataegus pinnatifida Bge. var. major.

    Science.gov (United States)

    Ying, Xixiang; Wang, Rongxiang; Xu, Jing; Zhang, Wenjie; Li, Haibo; Zhang, Chaoshen; Li, Famei

    2009-03-01

    A simple high-performance liquid chromatographic (HPLC) assay using the internal standard method is developed for the simultaneous determination of eight polyphenols. The analyzed compounds isolated from the leaves of Crataegus pinnatifida Bge. var. major include chlorogenic acid, vitexin-4"-O-glucoside, vitexin-2"-O-rhamnoside, vitexin, rutin, hyperoside, isoquercitrin, and quercetin. HPLC analysis is performed on a Diamonsil C18 analytical column (150 x 4.6 mm, i.d., 5-microm) using solvent (A) acetonitrile-tetrahydrofuran (95:5, v/v) and (B) 1% aqueous phosphoric acid as the mobile phase with UV absorption at 270 nm. The calibration curves of the eight polyphenols are linear (r(2) > 0.9992) over the concentration range of 0.0894-120.0 microg/mL. The mean recoveries are 95.4% to 98.1%. The results indicate that the HPLC method developed can easily be applied to the determination of eight polyphenols in the leaves of Crataegus pinnatifida Bge. var. major.

  20. Biosorption of mercury by Macrocystis pyrifera and Undaria pinnatifida: Influence of zinc, cadmium and nickel

    Institute of Scientific and Technical Information of China (English)

    Josefina Plaza; Marisa Viera; Edgardo Donati; Eric Guibal

    2011-01-01

    This study investigated the adsorption of Hg(Ⅱ) on Macrocystis pyrifera and Undaria pinnatifida in monometallic system in the presence of Zn(Ⅱ),Cd(Ⅱ) and Ni(Ⅱ).The two biosorbents reached the same maximum sorption capacity (qm =0.8 mmol/g) for mercury.U.pinnatifida showed a greater affinity (given by the coefficient b of the Langmuir equation) for mercury compared to M.pyrifera (4.4 versus 2.7 L/mmol).Mercury uptake was significantly reduced (by more than 50%) in the presence of competitor heavy metals such as Zn(Ⅱ),Cd(Ⅱ) and Ni(Ⅱ).Samples analysis using an environmental scanning electron microscopy equipped with an energy dispersive X-ray microanalysis showed that mercury was heterogeneously adsorbed on the surface of both biomaterials,while the other heavy metals were homogeneous distributed.The analysis of biosorbents by Fourier transform infrared spectrometry indicated that Hg(Ⅱ)binding occurred on S=O (sulfonate) and N-H (amine) functional groups.

  1. Conversion of Undaria pinnatifida residue to glycolic acid with recyclable methylamine in low temperature hydrothermal liquefaction.

    Science.gov (United States)

    Chen, Yongxing; Ren, Xiulian; Wei, Qifeng

    2017-03-01

    The conversion of Undaria pinnatifida residue to glycolic acid was carried out using methylamine as catalyst by hydrothermal method at relatively low temperature. GC-MS and HPLC were used to identify the composition of bio-oil and liquid products which provide the knowledge of the chemical reaction pathways of the hydrothermal liquefaction. The main liquid product was organic acid which contained glycolic acid, lactic acid, formic acid and acetic acid. And the major organic acid was glycolic acid with the highest yield of 46.52% or 33.98% of dry biomass. Methylamine promoted the dissolution of cellulose from Undaria pinnatifida residue, and significantly improved the yield of glycolic acid. The mechanism of HTL was investigated and the results show that the carbocation C3 was attacked by methylamine molecule which led to the high yield of glycolic acid. In addition, the recovery of methylamine was studied and the highest recovery rate reached 99.28%. Copyright © 2016 Elsevier Ltd. All rights reserved.

  2. Separation, characterization and anticancer activities of a sulfated polysaccharide from Undaria pinnatifida.

    Science.gov (United States)

    Han, Yun; Wu, Jun; Liu, Tingting; Hu, Youdong; Zheng, Qiusheng; Wang, Binsheng; Lin, Haiyan; Li, Xia

    2016-02-01

    The purpose of this paper was to investigate separation, characterization and anticancer activities of a sulfated polysaccharide (SPUP) from Undaria pinnatifida. Firstly, polysaccharide from U. pinnatifida was separated by DEAE-52 cellulose and Sephacryl S-400 column chromatography. As results, SPUP was obtained with the yield of 19.42%. Then, SPUP was characterized using chemical analysis, gas chromatography, size-exclusion HPLC chromatography, UV-vis spectra and FT-IR spectrum. The content of total sugar, uronic acid, protein and sulfate radical were 80.48%, 3.21%, 7.12% and 29.14%, respectively. SPUP was a heteropolysaccharide composed of fucose, glucose and galactose in a molar percentage of 27.15:19.34:53.51 with molecular weight of 97.9 kDa. Finally, the strongly against breast cancer activity of SPUP was confirmed by DMBA-induced breast cancer rats model. AS results, SPUP can significantly restrain breast abnormal enlargement, prolong tumor latency and reduced tumor incidence. Immunomodulatory activity and regulating abnormal sex hormones level might contribute to its anticancer activities.

  3. The Development of Undaria Pinnatifida Bean Curd%裙带菜保健豆腐的研制

    Institute of Scientific and Technical Information of China (English)

    李兴霞

    2014-01-01

    以裙带菜汁、大豆为主要原料,葡萄糖酸-δ-内酯(GDL)为凝固剂,研制出一种色泽浅绿,营养丰富的裙带菜豆腐。采用单因素实验确定裙带菜汁的添加量和豆浆的浓度,通过三因素三水平实验确定凝固的工艺条件,通过四因素三水平试验确定裙带菜豆腐的最佳配方,工艺条件是:裙带菜的添加量是20%,豆与水的比例是1∶4.5,GDL的用量为0.30%,凝固时间是15 min,凝固温度是95℃。%Using Undaria pinnatifida juice and soya bean as main material,glucono delta lactone (GDL) as coagulant,we produced light green and very nourishing Undaria pinnatifida bean curd.Using the single factor experiment to determine the quantity and concentration of Undaria pinnatifida juice milk, process conditions of coagulation is determined by three factors three levels experiment, the best formulation of Undaria pinnatifida tofu is determined by test of four factors and three levels, process conditions are: the addition of Undaria pinnatifida is 20%, soya-bean milk concentration is1∶4.5, the amount of GDL is 0.30%, solidification time is 15 min, solidification temperature is 95℃.

  4. Technical Report for a Study on the Improvement of Extraction Process and Physiological Activities of Polysaccharides from Undaria pinnatifida by Gamma Irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Jong Il; Lee, Ju Won; Kim, Jae Hun; Yoon, Yo Han; Song, Beom Seok; Yoon, Min Chul; Sung, Nak Yun; Lee, Hak Jyung

    2010-06-15

    By reason of Undaria pinnatifida growth is temperature dependent, U. pinnatifida produced in April and May are obtained as the main byproducts and it is normally wasted. The objective of the this study was investigated to the improvement of extraction process and physiological activities of polysaccharides from U. pinnatifida by gamma irradiation. The extraction yield of fucoidan and laminarrin was increased by gamma irradiation, and the molecular weight of extracted polysaccharides was decreased by irradiation. The effect of gamma irradiation on storage of U. pinnatifida was investigated. No viable cells were observed in samples irradiated at 3 and 5 kGy. Finally, fucoidan and laminarin were applied in the pork patty, and it was shown that lower lipid oxidation and positive effect on microbial stability and quality of the pork patty. These results will suggest that radiation technology can be applied for the extraction of functional materials and storages safe of the seaweeds

  5. A dark business, full of shadows: analogy and theology in William Harvey.

    Science.gov (United States)

    Goldberg, Benjamin

    2013-09-01

    In a short work called De conceptione appended to the end of his Exercitationes de generatione animalium (1651), William Harvey developed a rather strange analogy. To explain how such marvelous productions as living beings were generated from the rather inauspicious ingredients of animal reproduction, Harvey argued that conception in the womb was like conception in the brain. It was mostly rejected at the time; it now seems a ludicrous theory based upon homonymy. However, this analogy offers insight into the structure and function of analogies in early modern natural philosophy. In this essay I hope to not only describe the complex nature of Harvey's analogy, but also offer a novel interpretation of his use of analogical reasoning, substantially revising the account offered by Guido Giglioni (1993). I discuss two points of conceptual change and negotiation in connection with Harvey's analogy, understanding it as both a confrontation between the border of the natural and the supernatural, as well as a moment in the history of psychology. My interpretation touches upon a number of important aspects, including why the analogy was rejected, how Harvey systematically deployed analogies according to his notions of natural philosophical method, how the analogy fits into contemporary discussions of analogies in science, and finally, how the analogy must be seen in the context of changing Renaissance notions of the science of the soul, ultimately confronting the problem of how to understand final causality in Aristotelian science. In connection with the last, I conclude the essay by turning to how Harvey embeds the analogy within a natural theological cosmology.

  6. 76 FR 36314 - Safety Zone; Mile Marker 98.5 West of Harvey Lock Gulf Intracoastal Waterway to Mile Marker 108.5...

    Science.gov (United States)

    2011-06-22

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Mile Marker 98.5 West of Harvey Lock Gulf Intracoastal Waterway to Mile Marker 108.5 West of Harvey Lock Gulf Intracoastal Waterway AGENCY: Coast Guard... imposing restrictions on the Gulf Intracoastal Waterway (GIWW) between West Harvey Lock Gulf West...

  7. Cytotoxic and antioxidant dihydrobenzofuran neolignans from the seeds of Crataegus pinnatifida.

    Science.gov (United States)

    Huang, Xiao-Xiao; Zhou, Chen-Chen; Li, Ling-Zhi; Peng, Ying; Lou, Li-Li; Liu, Sen; Li, Dian-Ming; Ikejima, Takshi; Song, Shao-Jiang

    2013-12-01

    Eight new dihydrobenzofuran neolignans, pinnatifidanin C I-VIII (1-8), together with two known analogs (9-10) were isolated from the seeds of Crataegus pinnatifida. Their structures were elucidated by spectroscopic analyses, especially 1D, 2D NMR and CD spectra. The cytotoxic activities of all isolates against human cancer cell lines were assayed, and most interestingly, compound 10 revealed preferred cytotoxicity on the HT-1080 cell line and displayed much stronger inhibitory activity (IC50=8.86 μM) compared with positive control 5-fluorouracil (IC50=35.62 μM). Meanwhile, antioxidant activities of all the isolates were evaluated using 2,2-diphenyl-1-pikrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays, and the results showed that most of the isolates exhibited potent antioxidant activity. © 2013.

  8. Isolation of antithrombotic phenolic compounds from the leaves of Crataegus pinnatifida.

    Science.gov (United States)

    Song, Shao-Jiang; Li, Ling-Zhi; Gao, Pin-Yi; Yuan, Yan-Qiang; Wang, Ru-Ping; Liu, Ke-Chun; Peng, Ying

    2012-12-01

    Four novel phenolic compounds (1-4) were isolated from the leaves of Crataegus pinnatifida, along with three known ones (5-7). Their structures were elucidated as: methyl 4-O-β-D-glucopyranosyl-3-[(2E,6E)-8-O-β-D-glucopyranosyl-3,7-dimethyl-2,6-octadienyl] benzoate (1), biphenyl-5-ol-3-O-β-D-glucoside (2), 3,4'-dimethoxy-biphenyl-5-ol-4-O-β-D-glucoside (3), (E)-6-(benzoyloxy)-1-hydroxyhex-3-en-2-O-β-D-glucoside (4), shanyenoside A (5), eriodectyol (6), and 2″-O-rhamnosyl vitexin (7), using a combination of mass spectroscopy, 1D and 2D NMR spectroscopy, and chemical analysis. The antithrombotic activity of the isolated compounds was investigated on the transgenic zebra fish system. Among them, eriodectyol (6) potently inhibited the production of thrombus. Georg Thieme Verlag KG Stuttgart · New York.

  9. The cytotoxicity of 8-O-4' neolignans from the seeds of Crataegus pinnatifida.

    Science.gov (United States)

    Huang, Xiao-Xiao; Zhou, Chen-Chen; Li, Ling-Zhi; Li, Fei-Fei; Lou, Li-Li; Li, Dian-Ming; Ikejima, Takshi; Peng, Ying; Song, Shao-Jiang

    2013-10-15

    Nine new 8-O-4' neolignans, named pinnatifidanin B I-IX (1-9), together with 9 known analogs (10-18) were isolated from the seeds of Crataegus pinnatifida. The structures of 1-18 were determined by spectroscopic methods, including 1D, 2D NMR, CD and HRESIMS analysis. Compounds 8-11, 17 and 18 displayed potent cytotoxic activities against human cancer cell lines, and most interestingly, none of the 6 compounds displayed inhibitory activity against human lung cell line (Mrc5). The 6 cytotoxic compounds are considered to be potential as antitumor agents, which could significantly inhibit the cancer cell growth in a dose-dependent manner and are probably safer than positive control drug. Copyright © 2013 Elsevier Ltd. All rights reserved.

  10. Evaluation of Marine Algae Wakame (Undaria pinnatifida and Kombu (Laminaria digitata japonica as Food Supplements

    Directory of Open Access Journals (Sweden)

    Luciana Vallorani

    2004-01-01

    Full Text Available Crude proteins and their amino acid composition, -carotene, vitamins B1, B2, B6, niacin and minerals were determined in two edible brown marine algae (Phaeophyceae, Wakame (Undaria pinnatifida and Kombu (Laminaria digitata japonica. The amino acid scores for five key essential amino acids, frequently deficient in mixed human diet, and essential amino acid index were calculated. The results have shown the presence of all essential amino acids. The values of essential amino acid ratios of analysed algae exceed the ratios of reference proteins suggested by FAO/WHO/UNU, except for tryptophan, the first limiting amino acid in both analysed algae. Iodine, the most important component of sea vegetables is present in high amounts as well as the vitamins B1, B2, B6, niacin and β-carotene. The content of minerals was found high, while the presence of heavy metals was negligible.

  11. William Harvey & Capillaries: Can You "Discover" Circulation without Connections between Arteries & Veins?

    Science.gov (United States)

    Allchin, Douglas

    2005-01-01

    William Harvey's discovery of the presence of capillaries and the role played by them without actually seeing them highlights his power of observation and logic. However, his perspective could not be considered as new since he had adopted his disposition for ocular demonstration from Aristotle and Galen.

  12. Some ecological and biochemical observations on Caloglossa lepreiurii (Harvey) from Zuri estuary, Goa

    Digital Repository Service at National Institute of Oceanography (India)

    Jagtap, T.G.; Untawale, A.G.

    Ecology of Caloglossa leprieurii (Harvey) a benthic algal species from mangrove swamp was studied in relation to the climatological and hydrological factors. Maximum biomass of 11.7 g/m2 (wet weight) was recorded in October, which decreased during...

  13. The portrait of Dr William Harvey in the Royal Society since 1683.

    Science.gov (United States)

    Keynes, Milo

    2006-09-22

    A portrait of William Harvey in the Royal Society since 1683 is a copy by an unknown artist after a portrait, now lost, painted by Sir Peter Lely ca. 1650. Three other unattributed copies besides a copy bought from Lely's studio on his death by the Earl of Bradford have been located. The present labelling of the Royal Society portrait should be corrected.

  14. Effects of Undaria pinnatifida, Himanthalia elongata and Porphyra umbilicalis extracts on in vitro α-glucosidase activity and glucose diffusion

    OpenAIRE

    2014-01-01

    Background: Seaweeds are good sources of dietary fibre, which can influence glucose uptake and glycemic control. Objective: To investigate and compare the in vitro inhibitory activity of different extracts from Undaria pinnatifida (Wakame), Himanthalia elongata (Sea spaghetti) and Porphyra umbilicalis (Nori) on α-glucosidase activity and glucose diffusion. Methods: The in vitro effects chloroform-, ethanol- and water-soluble extracts of the three algae were assayed on α- glucosidase activity ...

  15. Harvey, Mark S. (2003: Catalogue of the smaller arachnid orders of the world: Amblypygi, Uropygi, Schizomida, Palpigradi, Ricinulei and Solifugae

    Directory of Open Access Journals (Sweden)

    Blick, Theo

    2004-11-01

    Full Text Available book review: Harvey Mark S. (2003: Catalogue of the smaller arachnid orders of the world: Amblypygi, Uropygi, Schizomida, Palpigradi, Ricinulei and Solifugae. Includes checklists for Europe of: Amblypygi, Uropygi, Schizomida, Palpigradi, Solifugae.

  16. Controllability of Boolean networks via input controls under Harvey's update scheme.

    Science.gov (United States)

    Luo, Chao; Zhang, Xiaolin; Shao, Rui; Zheng, YuanJie

    2016-02-01

    In this article, the controllability of Boolean networks via input controls under Harvey's update scheme is investigated. First, the model of Boolean control networks under Harvey's stochastic update is proposed, by means of semi-tensor product approach, which is converted into discrete-time linear representation. And, a general formula of control-depending network transition matrix is provided. Second, based on discrete-time dynamics, controllability of the proposed model is analytically discussed by revealing the necessary and sufficient conditions of the reachable sets, respectively, for three kinds of controls, i.e., free Boolean control sequence, input control networks, and close-loop control. Examples are showed to demonstrate the effectiveness and feasibility of the proposed scheme.

  17. Controllability of Boolean networks via input controls under Harvey's update scheme

    Science.gov (United States)

    Luo, Chao; Zhang, Xiaolin; Shao, Rui; Zheng, YuanJie

    2016-02-01

    In this article, the controllability of Boolean networks via input controls under Harvey's update scheme is investigated. First, the model of Boolean control networks under Harvey's stochastic update is proposed, by means of semi-tensor product approach, which is converted into discrete-time linear representation. And, a general formula of control-depending network transition matrix is provided. Second, based on discrete-time dynamics, controllability of the proposed model is analytically discussed by revealing the necessary and sufficient conditions of the reachable sets, respectively, for three kinds of controls, i.e., free Boolean control sequence, input control networks, and close-loop control. Examples are showed to demonstrate the effectiveness and feasibility of the proposed scheme.

  18. Capitalismo, cidade e política na perspectiva de David Harvey

    Directory of Open Access Journals (Sweden)

    Marco Aurélio Santana

    2013-06-01

    Full Text Available O texto discute alguns eixos conceituais relevantes para a compreensão da obra de David Harvey, concentrando-se especificamente nas formulações do autor acerca da ideia de rearranjo espacial (spatial fix, de novo imperialismo (new imperialism e de acumulação mediante despossessão (acumulation by dispossession. Objetiva-se lidar também com o que se seriam os componentes da teoria critica de Harvey. Além disso, apresenta-se como tais ideias e formulações não podem ser plenamente entendidas sem o seu enraizamento nas reflexões do autor acerca das cidades.

  19. Greek underpinnings to his methodology in unraveling De Motu Cordis and what Harvey has to teach us still today.

    Science.gov (United States)

    Pasipoularides, Ares

    2013-10-09

    William Harvey's writings betray amazing insights born out of countless hours of thoughtful experimentation. Throughout his life, Harvey worked as a tireless and thoughtful researcher and a transmitter and intermediary between the ancient Greek natural philosophers and physicians and the "moderns," for whom he founded two forward-looking, interlinked sciences: modern physiology and nascent cardiology. Harvey's methodology and demonstrations were of such fundamental and standardizing nature as to secure the sure progress of these two sciences. Thus, he rendered to them such a service as Descartes's cogito ergo sum furnished to Philosophy in giving it a rational standard of certainty, for want of which the more speculative minds of that era were inundated with extraordinary conjectures. If Harvey disproved Galen, he absorbed and continued in his physiologic research many a principle from Aristotle, whose supreme disciple he remains. The guidance and authority of Aristotle were strong with him to the end. Harvey's account of the motions of the heart and blood in the circulation demonstrated that complex physiological systems can be represented in straightforward mechanical terms, a concept which has remained fundamental to the present day. The philosophical implication of William Harvey's discovery of the circulation of the blood was the resolute application of the experimental method to cardiology. In my judgment, he established today's forward-looking discipline of translational cardiovascular research. In due course, he should be widely acknowledged to have done so.

  20. The correspondence and collaboration of Harvey Cushing and Irvine Page: Lessons from the Cleveland Clinic Archives

    OpenAIRE

    Abdullah, Kalil G.; Daniel Lubelski; Frederick Lautzenheiser; Thomas E Mroz

    2015-01-01

    Harvey Cushing is well-known as a pioneer of brain surgery and is considered the father of modern neurosurgery. However, Cushing′s interests and contributions extend beyond neurosurgery. Through his determined interdisciplinary collaboration in medicine and biomedical research, Cushing was able to contribute to numerous fields including bacteriology, anesthesiology, and endocrinology. With regards to the latter, Cushing corresponds with Irvine Page, well-known for isolating serotonin, discove...

  1. Wakame (Undaria pinnatifida ) modulates hyperphosphatemia in a rat model of chronic renal failure.

    Science.gov (United States)

    Katai, Kanako; Iwamoto, Aya; Kimura, Yuka; Oshima, Yuki; Arioka, Saori; Morimi, Yuki; Omuro, Ayaka; Nakasa, Teruko

    2015-01-01

    In chronic renal failure, inorganic phosphate (Pi) retention speeds up the progression to end-stage renal disease. The current therapy for hyperphosphatemia in patients with chronic renal failure consists of dietary Pi restriction combined with administration of Pi binders, but each therapy has practical problems. Thus, the discovery of foods or nutrients that inhibit Pi absorption may be useful for the treatment of hyperphosphatemia. In the present study, we investigated whether wakame (Undaria pinnatifida) is a useful food for the prevention of hyperphosphatemia in a rat model of renal failure. Feeding a diet containing 5% wakame significantly decreased plasma and urinary Pi levels and increased the amount of fecal Pi. In addition, wakame significantly reduced plasma blood urea nitrogen and plasma Pi levels in 5/6 nephrectomized rats fed a high-Pi diet. Biochemical analyses showed that the reduction of intestinal Pi absorption is the main reason for the decrease in plasma Pi levels in rats fed a diet containing wakame. In addition, feeding alginic acid and fucoidan, major components of wakame fiber, was effective in reducing plasma Pi levels in normal rats. Finally, we concluded that wakame may be a useful food for the prevention of hyperphosphatemia in rodents.

  2. Protective effect of extract of Crataegus pinnatifida pollen on DNA damage response to oxidative stress.

    Science.gov (United States)

    Cheng, Ni; Wang, Yuan; Gao, Hui; Yuan, Jialing; Feng, Fan; Cao, Wei; Zheng, Jianbin

    2013-09-01

    The protective effect of extract of Crataegus pinnatifida (Rosaceae) pollen (ECPP) on the DNA damage response to oxidative stress was investigated and assessed with an alkaline single-cell gel electrophoresis (SCGE) assay and pBR322 plasmid DNA breaks in site-specific and non-site-specific systems. Total phenolic content, total flavonoid content, individual phenolic compounds, antioxidant activities (1,1-diphenyl-2-picrylhydrazyl (DPPH), radical scavenging activity, FRAP, and chelating activity) were also determined. The results showed that ECPP possessed a strong ability to protect DNA from being damaged by hydroxyl radicals in both the site-specific system and the non-site-specific system. It also exhibited a cytoprotection effect in mouse lymphocytes against H₂O₂-induced DNA damage. These protective effects may be related to its high total phenolic content (17.65±0.97 mg GAE/g), total flavonoid content (8.04±0.97 mg rutin/g), strong free radical scavenging activity and considerable ferrous ion chelating ability (14.48±0.21 mg Na₂EDTA/g). Copyright © 2013 Elsevier Ltd. All rights reserved.

  3. Study on gametophyte vegetative growth of Undaria pinnatifida and its applications

    Science.gov (United States)

    Pang, Shao-Jun; Wu, Chao-Yuan

    1996-09-01

    When cultured under certain environmental conditions (25°C, light intensity 80 μmol/m2·s, LD 12/12, in enriched seawater medium with 7×10-4 mol/L NO3-N, 1.56×10-4 mol/L, PO4-P and supplements of other elements like Mn, Fe, I, etc.), male and female gametophytes of U. pinnatifida kept growing vegetatively and propagated fast at average daily fresh weight increase rate of about 20%. The empirical formula G m= G o·3m was established to estimate the output of vegetative gametophytes. Vigorous vegetative gametophyte cells began to form reproductive structures (oogonium and spermatangium, when the temperature was lower than 25°C and other environmental factors were kept optimal. The sufficient supply of gametophyte cells provided enough seeds for raising Undaria sporelings on production scale. Controlled cross-breeding experiments using selected male and female gametophyte clones which increase their cell number by mitosis instead of meiosis were also carried out in vitro. Juvenile sporophytes from the cross-breeding had almost the same length and width increase rates as those of the control. The fact that vegetative gametophytes can be purposely selected, propagated quickly, cross-bred, with the resulting sporophytes having almost the same characteristics leads to a new way to select desired Undaria strains for long time use without losing the desired economic characteristics.

  4. Biosorption of chromium(III) by two Brown algae macrocystis pyrifera and undaria pinnatifida: equilibrium and kinetic study

    Energy Technology Data Exchange (ETDEWEB)

    Cazon, Josefina Plaza H.; Benitez, Leonardo; Donati, Edgardo; Viera, Marisa [Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Calle 47 y 115 (1900) La Plata (Argentina)

    2012-02-15

    Two brown algae, Macrocystis pyrifera and Undaria pinnatifida, were employed to remove Cr(III) from aqueous solutions. Both seaweeds were characterized in terms of alginate yields. The alginate contents were 20 and 30% of the dry weight for M. pyrifera and U. pinnatifida, respectively. Kinetics experiments were carried out at different initial pH values. Cr(III) biosorption was affected by the solution pH. The highest metal uptake was found at pH 4 for both biosorbents. Different models were applied to elucidate the rate-controlling mechanism: pseudo-first-order, pseudo-second-order, external mass transfer and intra-particle diffusion. The application of Langmuir, Freundlich and Dubinin-Radushkevich models to the equilibrium data showed a better fitting to the first model. The maximum Cr(III) sorption capacity (q{sub m}) and the affinity coefficient (b) were very similar for both biosorbents: 0.77 mmol/g and 1.20 L/mmol for M. pyrifera and 0.74 mmol/g and 1.06 L/mmol for U. pinnatifida. The free energy of the sorption process was estimated using the Dubinin-Radushkevich isotherm. The values indicate that the processes are chemical sorptions. To evaluate the significance of the ion-exchange mechanism, the light metals (Ca{sup 2+}, Na{sup +}, Mg{sup 2+} and K{sup +}) and pH were measured during the experiments. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  5. The Antioxidant and Tyrosinase-inhibiting Activities of 8-O-4′ N eolignans from Crataegus pinnatifida Seeds

    Directory of Open Access Journals (Sweden)

    Xiao-Xiao Huang

    2015-04-01

    Full Text Available Many tyrosinase inhibitors have been alleged to have serious side effects. To search for relatively mild and safe tyrosinase inhibitors, two new 8-O-4′ neolignans, named huangnin A (1 and B (2, and four known analogs (3-6 were isolated from the seeds of Crataegus pinnatifida. Their structures were elucidated by spectroscopic analyses (1D, 2D NMR, HRESIMS, CD and Rh 2(OCOCF 3 4-induced CD. In addition, the in vitro antioxidant and anti-tyrosinase activities of all isolates were evaluated. The results showed that compound 5 has good antioxidant and promising tyrosinase-inhibiting activities.

  6. In vitro assessment of the effect of Undaria pinnatifida extracts on erythrocytes membrane integrity and blood coagulation parameters of Equus caballus

    Institute of Scientific and Technical Information of China (English)

    Caterina Faggio; Maria Pagano; Marina Morabito; Simona Armeli Minicante; Francesca Arfuso; Giuseppa Genovese

    2014-01-01

    Objective: To study the activity of polysaccharides extracted from Undaria pinnatifida (U. pinnatifida) in vitro on red blood cell of Equus caballus, and compare it with heparin. Methods:Algal extracts was tested at two different concentrations 10 mg/mL and 20 mg/mL. In all studies, using horse red blood cells, control experiments were carried out without extract. We evaluated the toxicity of algal extracts through trypan blue test and haemolysis test and anticoagulant action measured by activated partial thromboplastin time, prothrombin time and fibrinogen test. Results:The polysaccharide extract of U. pinnatifida appeared to have no cytotoxic effect on the horse red blood cells. The values of prothrombin time, activated partial thromboplastin time and fibrinogen were significantly changed in the presence of the extract. Conclusions:This study suggests a possible exploitation of U. pinnatifida, thriving in the lagoon of Venice, as a source of anticoagulant drug, with the aim of transforming waste into a valuable biomass.

  7. In vitro assessment of the effect of Undaria pinnatifida extracts on erythrocytes membrane integrity and blood coagulation parameters of Equus caballus

    Directory of Open Access Journals (Sweden)

    Caterina Faggio

    2014-08-01

    Full Text Available Objective: To study the activity of polysaccharides extracted from Undaria pinnatifida (U. pinnatifida in vitro on red blood cell of Equus caballus, and compare it with heparin. Methods: Algal extracts was tested at two different concentrations 10 mg/mL and 20 mg/mL. In all studies, using horse red blood cells, control experiments were carried out without extract. We evaluated the toxicity of algal extracts through trypan blue test and haemolysis test and anticoagulant action measured by activated partial thromboplastin time, prothrombin time and fibrinogen test. Results: The polysaccharide extract of U. pinnatifida appeared to have no cytotoxic effect on the horse red blood cells. The values of prothrombin time, activated partial thromboplastin time and fibrinogen were significantly changed in the presence of the extract. Conclusions: This study suggests a possible exploitation of U. pinnatifida, thriving in the lagoon of Venice, as a source of anticoagulant drug, with the aim of transforming waste into a valuable biomass.

  8. Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin.

    Science.gov (United States)

    Hwang, Eunson; Park, Sang-Yong; Yin, Chang Shik; Kim, Hee-Taek; Kim, Yong Min; Yi, Tae Hoo

    2017-01-01

    Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of P. ginseng Meyer and C. pinnatifida (GC) would have protective effects against skin aging. Anti-aging activity was examined both in human dermal fibroblasts under UVB irradiation by using Western blot analysis and in healthy human skin by examining noninvasive measurements. In vitro studies showed that GC improved procollagen type I expression and diminished matrix metalloproteinase-1 secretion. Based on noninvasive measurements, skin roughness values, including total roughness (R1), maximum roughness (R2), smoothness depth and average roughness (R3), and global photodamage scores were improved by GC application. Moreover, GC ameliorated the high values of smoothness depth (R4), which means that GC reduced loss of skin moisture. These results suggest that GC can prevent aging by inhibiting wrinkle formation and increasing moisture in the human skin.

  9. Anti-inflammatory potential of flavonoid contents from dried fruit of Crataegus pinnatifida in vitro and in vivo.

    Science.gov (United States)

    Kao, Erl-Shyh; Wang, Chau-Jong; Lin, Wea-Lung; Yin, Yu-Fang; Wang, Chi-Pin; Tseng, Tsui-Hwa

    2005-01-26

    The dried fruits of Crataegus pinnatifida, a local soft drink material and medical herb, demonstrated antioxidant effect in a previous study. The present study investigates the anti-inflammatory potential of flavonoid contents from dried fruit of C. pinnatifida (CF-Fs). The preliminary investigation showed that CF-Fs (0.25-0.75 mg/mL) decreased the release of PGE2 and nitric oxide as induced by lipopolysaccharide (LPS, an endotoxin) in macrophage RAW 264.7 cells. The in vivo assay showed that pretreatment of rats with CF-Fs (50-200 mg/kg dosed by gavage) for 5 days significantly decreased the serum levels of the hepatic enzyme markers alanine aminotransferase and aspartate aminotransferase induced by the 6-h treatment with LPS (i.p.; 5 mg/kg). Histopathological evaluation of the rat livers revealed that CF-Fs reduced the incidence of liver lesions such as neutrophil infiltration and necrosis induced by LPS. Furthermore, it was found that pretreatment with CF-Fs decreased the hepatic expression of iNOS and COX-2 induced by LPS in rats. These results demonstrate that CF-Fs present anti-inflammatory potential in vitro and in vivo and that they may play a role in hepatoprotection.

  10. Zoospores of Undaria pinnatifida: their efficiency to attach under different water velocities and conjugation behavior during attachment

    Institute of Scientific and Technical Information of China (English)

    PANG Shaojun; SHAN Tifeng

    2008-01-01

    In the invading course of Undaria pinnatifida,zoospore attachment in a dynamically changed subtidal water environment is crucial for the establishment of a potential population in alien waters.Among many abiotic factors that may interfere with the attachment process,water velocity is the most important one.In this investigation,the effect of water velocity on zoospore attachment of U.pinnatifida was investigated in an artificially designed system.It was found that freshly released zoospores that were transported by water flowing at 0 ~ 16 cm/s showed no difficulty in attaching the smooth surface.Zoospore attachment decreased at elevated water flowing rates.At 70 cm/s no spore attachment occurred.Spores that have settled on glass slide for up to 1 h could not be stripped away by flowing water at a rate of 129 cm/s,the same was true of the 20 d old filamentous gametophytes.It was found that more than 70% of free-swimming zoospores tended to settle down adjacent to the settled spores and formed conjugated clusters from two up to a few hundred cells in still culture.

  11. "With much nausea, loathing, and foetor": William Harvey, dissection, and dispassion in early modern medicine.

    Science.gov (United States)

    Payne, Lynda

    2002-12-01

    In early modern England accumulating knowledge of normal and morbid anatomy through dissecting the human body not only led to a better understanding of nature, but also defined the identity of the people who engaged in this activity. This essay analyses the relationship between systemically dismembering the dead and how this pursuit shaped the attitudes and emotions of early modern medical men toward the living. I focus on the most famous anatomist in early modern Britain - the discoverer of the circulation of the blood, William Harvey (1578-1657).

  12. William Harvey Research Conference on PDE inhibitors: drugs with an expanding range of therapeutic uses.

    Science.gov (United States)

    O'Donnell

    2000-03-01

    Presentations at the William Harvey Research Conference on PDE Inhibitors described the molecular biology, biochemical regulation. pharmacology, and therapeutic utility of inhibitors of cyclic nucleotide phosphodiesterases (PDEs). Most of the talks focused on PDE4 and PDE5. two members of the 11-member PDE family that have attracted much interest over the last several years. These enzymes have been shown to be targets for drugs with wide-ranging clinical utility, including treatment of inflammation, depression, and male erectile dysfunction. The continued investigation of PDEs and the development of potent and selective inhibitors should provide even more therapeutic agents in years to come.

  13. William S. Halsted and Harvey W. Cushing: reflections on their complex association.

    Science.gov (United States)

    Voorhees, Jennifer R; Tubbs, R Shane; Nahed, Brian; Cohen-Gadol, Aaron A

    2009-02-01

    William Stewart Halsted, the father of modern surgery, and Harvey Williams Cushing, the father of neurosurgery, are remembered for their countless innovations and contributions to the discipline of surgery. Between 1896 and 1912, they worked together at Johns Hopkins Hospital making many of their respective achievements possible. In the later years, their complex relationship, somewhat strained during Cushing's residency, grew into a mutual respect and deep appreciation for one another. In this offering, the authors attempt to elucidate the evolution of this complex relationship.

  14. Harvey Cushing’s Ghosts: Death and Hauntings in Modern Medicine

    OpenAIRE

    Shin, Paul

    2011-01-01

    The passing of Yale School of Medicine’s 2010 Bicentennial occasions a moment of reflecting on the past, present, and future of medical education and research at Yale and beyond. Last June, a ribbon-cutting ceremony inaugurated the opening of the Cushing Center in the Cushing-Whitney Medical Library. Named after Harvey Cushing, an early 20th-century neurosurgeon and former Yale College alum, the dual education/exhibition space now houses hundreds of gross brain specimens constituting the Cush...

  15. Numerical validation of the generalized Harvey-Shack surface scatter theory

    Science.gov (United States)

    Choi, Narak; Harvey, James E.

    2013-11-01

    The generalized Harvey-Shack (GHS) surface scatter theory is numerically compared to the classical small perturbation method, the Kirchhoff approximation method, and the rigorous method of moments for one-dimensional ideally conducting surfaces whose surface power spectral density function is Gaussian or exhibits an inverse power law (fractal) behavior. In spite of its simple analytic form, our numerical comparison shows that the new GHS theory is valid (with reasonable accuracy) over a broader range of surface parameter space than either of the two classical surface scatter theories.

  16. 别了,哈维·皮特%Farewell, Harvey Pitt

    Institute of Scientific and Technical Information of China (English)

    张文

    2003-01-01

    2002年11月5日,白宫宣布美国证券交易委员会(SEC)主席哈维·皮特(Harvey Pitt)已于当日正式辞职。上任仅15个月之后,在美国中期大选时皮特向布什总统提交了辞呈。据说正在收看中期选举电视转播的美国总统布什没有多加考虑,当即批准了这份辞职申请。

  17. [Reseña del libro de] David Harvey. Diecisiete contradicciones y el fin del capitalismo.

    OpenAIRE

    Labajos, Vidal

    2014-01-01

    [ES]La realidad problemática y en tensión constituye la materia prima de la crítica social; esto es, las contradicciones. David Harvey, autor de libros como La condición de la posmodernidad. Investigación sobre los orígenes del cambio cultural ([1989]1998) o Breve historia del neoliberalismo ([2005] 2007), hace de las contradicciones capitalistas su objeto de estudio principal en este último libro. Esquivando un estilo excesivamente farragoso, dedica gran parte de su interés a concretar un...

  18. Robert Willis (1799-1878): the works of William Harvey, M. D., London 1847. A bibliographical note.

    Science.gov (United States)

    Hildebrand, Reinhard

    2007-01-01

    Robert Willis was one of the early historians of medicine in Great Britain. He is recalled as a biographer and editor of the works of William Harvey. His translation of Harvey's 'Exercitatio de motu cordis et sanguinis in animalibus' of 1628 is appreciated as the standard rendering among all the English versions of this most influential dissertation. Willis' author's copy of 'The Works of William Harvey' with corrections and notes which, however, are not indicative of attempts at a revision of the text is to be found in the Library of the University of Münster at Westphalia in Germany. The book was donated along with 17,000 other books, in the years 1911/12 to the University Library by the German physician Dr Albert Voss who practised in the United States of America.

  19. 75 FR 71543 - Safety Zone; Gulf Intracoastal Waterway, Mile Marker 49.0 to 50.0, west of Harvey Locks, Bank to...

    Science.gov (United States)

    2010-11-24

    ....0 to 50.0, west of Harvey Locks, Bank to Bank, Bayou Blue Pontoon Bridge, Lafourche Parish, LA..., bank to bank, West of Harvey Locks, Lafourche Parish, LA. This Safety Zone is needed to protect the... repairs of the Bayou Blue Pontoon Bridge, Mile Marker 49.8, Gulf Intracoastal Waterway, West of...

  20. The absence of Harvey ras mutations during development and progression of squamous cell carcinomas of the head and neck.

    Science.gov (United States)

    Clark, L J; Edington, K; Swan, I R; McLay, K A; Newlands, W J; Wills, L C; Young, H A; Johnston, P W; Mitchell, R; Robertson, G

    1993-09-01

    We have examined the incidence of Harvey ras mutations in human squamous cell carcinomas (SCC) of the upper aerodigestive tract using the polymerase chain reaction (PCR) followed by direct sequencing. No mutations were detected at codons 12, 13, 59 or 61 of this gene in any of six papillomas, five erythroplakias, 56 squamous cell carcinomas, and 16 SCC cell lines. Some of the SCC were lymph node metastases (three) or tumours which had recurred following radiotherapy (seven). We conclude that Harvey ras mutations are not a common event in the pathogenesis or recurrence of SCCs from Caucasian subjects, in contrast to the situation with Indian populations (Saranath et al., 1991).

  1. Further genetic localization of the transforming sequences of the p21 v-ras gene of Harvey murine sarcoma virus

    DEFF Research Database (Denmark)

    Willumsen, B M; Ellis, R W; Scolnick, E M

    1984-01-01

    The sequences encoding the 21-kilodalton transforming protein (p21 ras) of Harvey murine sarcoma virus have previously been localized genetically to a 1.3-kilobase segment of the viral DNA (E. H. Chang, R. W. Ellis, E. M. Scolnick, and D. R. Lowy, Science 210:1249-1251, 1980). Within this segment...... of this open reading frame. By constructing a mutant of Harvey murine sarcoma virus DNA from which the first two ATG codons of this open reading frame have been deleted, we now show by transfection of the mutant viral DNA into NIH 3T3 cells that only the third ATG codon is necessary and sufficient...

  2. Challenges in early operative approaches to intramedullary spinal cord tumors: Harvey Cushing's perspective.

    Science.gov (United States)

    Pendleton, Courtney; Rincon-Torroella, Jordina; Gokaslan, Ziya L; Jallo, George I; Quinones-Hinojosa, Alfredo

    2015-10-01

    Although Harvey Cushing was mostly known for his contributions to brain tumor surgery, he was also a pioneer in the development of spinal cord surgery. This lesser known facet of Cushing's career can provide a fresh and unique perspective into how the founders of neurosurgery surmounted early challenges in the field. The authors bring to light and examine for the first time Cushing's unpublished writing "Technique of Laminectomy" along with his first 3 documented intramedullary spinal cord tumor (IMSCT) cases at the Johns Hopkins Hospital. The authors draw lessons from the challenges in pathological classification, preoperative diagnosis, tumor localization, and surgical technique of that time. Although Cushing's attempts at exploration and resection of IMSCT as described here were of limited success, his ability to adapt his clinical and surgical technique to the challenges of the time, as well as develop skills to successfully manipulate the spinal cord during these exploratory procedures without the patients incurring neurological damage, postoperative infection, or complications, is a testament to his determination to advance the field and his meticulous operative technique. In spite of the limitations imposed on the pioneer neurosurgeons, Harvey Cushing and his contemporaries persevered through many of the challenges and built an essential part of neurosurgery's common story.

  3. Reflections on the contributions of Harvey Cushing to the surgery of peripheral nerves.

    Science.gov (United States)

    Tubbs, R Shane; Patel, Neal; Nahed, Brian Vala; Cohen-Gadol, Aaron A; Spinner, Robert J

    2011-05-01

    By the time Harvey Cushing entered medical school, nerve reconstruction techniques had been developed, but peripheral nerve surgery was still in its infancy. As an assistant surgical resident influenced by Dr. William Halsted, Cushing wrote a series of reports on the use of cocaine for nerve blocks. Following his residency training and a hiatus to further his clinical interests and intellectual curiosity, he traveled to Europe and met with a variety of surgeons, physiologists, and scientists, who likely laid the groundwork for Cushing's increased interest in peripheral nerve surgery. Returning to The Johns Hopkins Hospital in 1901, he began documenting these surgeries. Patient records preserved at Yale's Cushing Brain Tumor Registry describe Cushing's repair of ulnar and radial nerves, as well as his exploration of the brachial plexus for nerve repair or reconstruction. The authors reviewed Harvey Cushing's cases and provide 3 case illustrations not previously reported by Cushing involving neurolysis, nerve repair, and neurotization. Additionally, Cushing's experience with facial nerve neurotization is reviewed. The history, physical examination, and operative notes shed light on Cushing's diagnosis, strategy, technique, and hence, his surgery on peripheral nerve injury. These contributions complement others he made to surgery of the peripheral nervous system dealing with nerve pain, entrapment, and tumor.

  4. Learning from Harvey Milk: The Limits and Opportunities of One Hero to Teach about LGBTQ People and Issues

    Science.gov (United States)

    Donahue, David M.

    2014-01-01

    Highlighting a hero is a common response to including the history of marginalized people in the curriculum. Harvey Milk is becoming that hero as social studies curriculum responds to calls for including LGBTQ people. By studying Milk, what might young people learn about LGBTQ people, issues, and movements? What opportunities and limitations exist…

  5. Theorising "Geo-Identity" and David Harvey's Space: School Choices of the Geographically Bound Middle-Class

    Science.gov (United States)

    Rowe, Emma

    2015-01-01

    This paper draws on David Harvey's theories of absolute and relational space in order to critique geographically bound school choices of the gentrified middle-class in the City of Melbourne, Australia. The paper relies on interviews with inner-city school choosers as generated by a longitudinal ethnographic school choice study. I argue that the…

  6. Theorising "Geo-Identity" and David Harvey's Space: School Choices of the Geographically Bound Middle-Class

    Science.gov (United States)

    Rowe, Emma

    2015-01-01

    This paper draws on David Harvey's theories of absolute and relational space in order to critique geographically bound school choices of the gentrified middle-class in the City of Melbourne, Australia. The paper relies on interviews with inner-city school choosers as generated by a longitudinal ethnographic school choice study. I argue that the…

  7. Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus

    DEFF Research Database (Denmark)

    Willumsen, B M; Norris, K; Papageorge, A G

    1984-01-01

    Previous studies of premature chain termination mutants and in frame deletion mutants of the p21 ras transforming protein encoded by the transforming gene of Harvey murine sarcoma virus (Ha-MuSV) have suggested that the C terminus is required for cellular transformation, lipid binding, and membrane...

  8. An extract of Crataegus pinnatifida fruit attenuates airway inflammation by modulation of matrix metalloproteinase-9 in ovalbumin induced asthma.

    Directory of Open Access Journals (Sweden)

    In Sik Shin

    Full Text Available BACKGROUND: Crataegus pinnatifida (Chinese hawthorn has long been used as a herbal medicine in Asia and Europe. It has been used for the treatment of various cardiovascular diseases such as myocardial weakness, tachycardia, hypertension and arteriosclerosis. In this study, we investigated the anti-inflammatory effects of Crataegus pinnatifida ethanolic extracts (CPEE on Th2-type cytokines, eosinophil infiltration, expression of matrix metalloproteinase (MMP-9, and other factors, using an ovalbumin (OVA-induced murine asthma model. METHODS/PRINCIPAL FINDING: Airways of OVA-sensitized mice exposed to OVA challenge developed eosinophilia, mucus hypersecretion and increased cytokine levels. CPEE was applied 1 h prior to OVA challenge. Mice were administered CPEE orally at doses of 100 and 200 mg/kg once daily on days 18-23. Bronchoalveolar lavage fluid (BALF was collected 48 h after the final OVA challenge. Levels of interleukin (IL-4 and IL-5 in BALF were measured using enzyme-linked immunosorbent (ELISA assays. Lung tissue sections 4 µm in thickness were stained with Mayer's hematoxylin and eosin for assessment of cell infiltration and mucus production with PAS staining, in conjunction with ELISA, and Western blot analyses for the expression of MMP-9, intercellular adhesion molecule (ICAM-1 and vascular cell adhesion molecule (VCAM-1 protein expression. CPEE significantly decreased the Th2 cytokines including IL-4 and IL-5 levels, reduced the number of inflammatory cells in BALF and airway hyperresponsiveness, suppressed the infiltration of eosinophil-rich inflammatory cells and mucus hypersecretion and reduced the expression of ICAM-1, VCAM-1 and MMP-9 and the activity of MMP-9 in lung tissue of OVA-challenged mice. CONCLUSIONS: These results showed that CPEE can protect against allergic airway inflammation and can act as an MMP-9 modulator to induce a reduction in ICAM-1 and VCAM-1 expression. In conclusion, we strongly suggest the feasibility

  9. Petrogenetic evolution of Late Paleozoic rhyolites of the Harvey Group, southwestern New Brunswick (Canada) hosting uranium mineralization

    Science.gov (United States)

    Dostal, J.; van Hengstum, T. R.; Shellnutt, J. G.; Hanley, J. J.

    2016-06-01

    The 360 Ma subaerial felsic volcanic and volcaniclastic rocks of the Harvey Group form a belt about 15 km long and 3 km wide in southwestern New Brunswick (Canada) that has been correlated with parts of the Mount Pleasant caldera complex, the site of a significant polymetallic (tin, tungsten, molybdenum, indium and bismuth) deposit. The Harvey volcanic rocks are highly fractionated peraluminous within-plate F-rich rhyolites, which host uranium mineralization. The rocks were modified by late-magmatic and post-magmatic processes. A comparison of the composition of whole rocks and melt inclusions in the quartz phenocrysts shows that some trace elements, including U, were affected by the post-magmatic processes. Their flat REE patterns accompanied by distinct negative Eu anomalies are typical of highly evolved F-rich leucogranites and rhyolites. Nd isotopic ratios (ɛNd(360) = +0.6 to -1.0) are similar to those of the felsic rocks of the Mount Pleasant complex. The Harvey rhyolites were generated by extensive fractional crystallization of andesites of the Mount Pleasant caldera. The melt evolved at the apex of the magma chamber where volatile elements become concentrated. The Harvey rhyolite (with melt inclusions containing ~20 ppm U) had the potential to develop a significant U mineralization. The erupted glassy rhyolite is a favorable U source rock amendable to leaching by post-magmatic hydrothermal and meteoric water. The high Th/U ratios in the Harvey volcanic rocks compared to the low ratios in the U-rich melt inclusions is indicative of such a process.

  10. The correspondence and collaboration of Harvey Cushing and Irvine Page: Lessons from the Cleveland Clinic Archives.

    Science.gov (United States)

    Abdullah, Kalil G; Lubelski, Daniel; Lautzenheiser, Frederick; Mroz, Thomas E

    2015-01-01

    Harvey Cushing is well-known as a pioneer of brain surgery and is considered the father of modern neurosurgery. However, Cushing's interests and contributions extend beyond neurosurgery. Through his determined interdisciplinary collaboration in medicine and biomedical research, Cushing was able to contribute to numerous fields including bacteriology, anesthesiology, and endocrinology. With regards to the latter, Cushing corresponds with Irvine Page, well-known for isolating serotonin, discovering the renin-angiotensin system, and postulating of the mosaic theory of hypertension. In a correspondence spanning 3 years, from January 1933 to April 1936, Cushing and Page collaborated to discover a substance responsible for hypertension. In this historical article, the authors review the letters to highlight the collaborative efforts between leaders in disparate fields driven by the scientific curiosity. As national research agencies are focusing their funds toward collaborative and interdisciplinary research, it is interesting to note the historical communication among the scientific leaders that led to discoveries in the respective fields.

  11. Harvey Cushing and some Australian connections: part 1 - early life and work.

    Science.gov (United States)

    Roxanas, M G

    2010-02-01

    Before World War 1 both the United States of America and Australia had rather rudimentary medical systems. Enterprising practitioners in both countries tended to look to continental Europe (especially Germany) and the United Kingdom as places of medical renown. The outbreak of World War 1 changed this but also enabled doctors from both the United States and Australia to work in military hospitals in Europe. The interactions that occurred were important for their professional development and led to some close associations between American and antipodean doctors. Examples of these were the experiences of Harvey Cushing, a burgeoning American neurosurgeon, which he recounted in his diary. His commentary merits close inspection and analysis. An account of some of Cushing's Australian connections post World War 1 is given in Part 2 (in press).

  12. Harvey Cushing and some Australian connections: Part 2--post World War 1.

    Science.gov (United States)

    Roxanas, M G

    2010-03-01

    Part 1 of this article (see Vol 17, pp. 168-172) described the early life of Harvey Cushing and his encounters with Australian doctors, mostly in various military hospitals, in France, in World War 1. As none of the doctors he met at that time became neurosurgeons, and hence did not shape their professional development. When World War 1 ended, HC returned to a heavy schedule of operating at the Peter Bent Brigham Hospital and to his university obligations. He received the Companion of the Bath from the British Government for his war services and wrote the history of US Base Hospital No. 5, which he directed during the War. Cushing's reputation as a neurosurgeon was now secure and he was ready to play an even greater part as an academic neurosurgeon, teaching students from all parts of the world and continuing his researches into cerebral tumours and the pituitary gland.

  13. Finite Geometry Behind the Harvey-Chryssanthacopoulos Four-Qubit Magic Rectangle

    CERN Document Server

    Saniga, Metod

    2012-01-01

    A "magic rectangle" of eleven observables of four qubits, employed by Harvey and Chryssanthacopoulos (2008) to prove the Bell-Kochen-Specker theorem in a 16-dimensional Hilbert space, is given a neat finite-geometrical reinterpretation in terms of the structure of the symplectic polar space $W(7, 2)$ of the real four-qubit Pauli group. Each of the four sets of observables of cardinality five represents an elliptic quadric in the three-dimensional projective space of order two (PG$(3, 2)$) it spans, whereas the remaining set of cardinality four corresponds to an affine plane of order two. The four ambient PG$(3, 2)$s of the quadrics intersect pairwise in a line, the resulting six lines meeting in a point. Projecting the whole configuration from this distinguished point (observable) one gets another, complementary "magic rectangle" of the same qualitative structure.

  14. David Harvey, The Enigma of Capital and the Crises of Capitalism

    Directory of Open Access Journals (Sweden)

    Hugo Dias

    2012-11-01

    Full Text Available David Harvey é, actualmente, uma das figuras incontornáveis quando nos debruçamos sobre as dinâmicas espacio‑temporais de desenvolvimento do capitalismo contemporâneo. O geógrafo ambicionou sempre defender uma certa noção de conhecimento, que admite a diversidade e a fragmentação, mas que daí não retira a conclusão da absoluta impotência para a construção de uma grelha de compreensão da realidade. Se o seu percurso inicial é marcado por um cunho positivista forte (que cedo abandona, é no ref...

  15. 哈维·华盛顿·威利%Harvey W.Wiley

    Institute of Scientific and Technical Information of China (English)

    焦玉洁

    2011-01-01

    哈维·华盛顿·威利( Harvey W.Wiley) 1844生于美国印第安纳州南部的一个农场,获哈佛大学医学博士学位,但却从未当过医生.他被称为“纯食品药品法之父”,创立的机构后来演变成为美国食品药品管理局(FDA).威利一手创办了美国官方分析化学师协会(AOAC),并以他的名字来颁布大奖.

  16. Grafting and cultivation management of Crataegus pinnatifida Bunge%大果山楂的嫁接技术与栽培管理

    Institute of Scientific and Technical Information of China (English)

    李丹

    2015-01-01

    This paper described the grafting techniques of Crataegus pinnatifida Bunge,and introduced the cultivation and management techniques from the garden,water and fertilizer management,soil management,shaping and pruning,plant diseases and insect pest control,and harvest etc. This cultivation techniques will provide technical support for the produc-tion of C. pinnatifida Bunge.%介绍了大果山楂的嫁接技术,从建园、水肥管理、土壤管理、整形修剪、病虫害防治和果实采收等方面较详细介绍了其栽培管理技术,旨为大果山楂的种植栽培提供技术支持。

  17. Undaria pinnatifida and Fucoxanthin Ameliorate Lipogenesis and Markers of Both Inflammation and Cardiovascular Dysfunction in an Animal Model of Diet-Induced Obesity

    Directory of Open Access Journals (Sweden)

    Ameyalli Grasa-López

    2016-08-01

    Full Text Available Brown algae and its carotenoids have been shown to have a positive influence on obesity and its comorbidities. This study evaluated the effect of Undaria pinnatifida and fucoxanthin on biochemical, physiological and inflammation markers related to obesity and on the expression of genes engaged on white adipose tissue lipid metabolism in a murine model of diet-induced obesity. The treatments improved energy expenditure, β-oxidation and adipogenesis by upregulating PPARα, PGC1α, PPARγ and UCP-1. Adipogenesis was also confirmed by image analysis of the retroperitoneal adipose tissue, by measuring cell area, perimeter and cellular density. Additionally, the treatments, ameliorated adipose tissue accumulation, insulin resistance, blood pressure, cholesterol and triglycerides concentration in serum, and reduced lipogenesis and inflammation by downregulating acetyl-CoA carboxylase (ACC gene expression, increasing serum concentration and expression of adiponectin as well as downregulating IL-6 expression. Both fucoxanthin and Undaria pinnatifida may be considered for treating obesity and other diseases related.

  18. Undaria pinnatifida and Fucoxanthin Ameliorate Lipogenesis and Markers of Both Inflammation and Cardiovascular Dysfunction in an Animal Model of Diet-Induced Obesity

    Science.gov (United States)

    Grasa-López, Ameyalli; Miliar-García, Ángel; Quevedo-Corona, Lucía; Paniagua-Castro, Norma; Escalona-Cardoso, Gerardo; Reyes-Maldonado, Elba; Jaramillo-Flores, María-Eugenia

    2016-01-01

    Brown algae and its carotenoids have been shown to have a positive influence on obesity and its comorbidities. This study evaluated the effect of Undaria pinnatifida and fucoxanthin on biochemical, physiological and inflammation markers related to obesity and on the expression of genes engaged on white adipose tissue lipid metabolism in a murine model of diet-induced obesity. The treatments improved energy expenditure, β-oxidation and adipogenesis by upregulating PPARα, PGC1α, PPARγ and UCP-1. Adipogenesis was also confirmed by image analysis of the retroperitoneal adipose tissue, by measuring cell area, perimeter and cellular density. Additionally, the treatments, ameliorated adipose tissue accumulation, insulin resistance, blood pressure, cholesterol and triglycerides concentration in serum, and reduced lipogenesis and inflammation by downregulating acetyl-CoA carboxylase (ACC) gene expression, increasing serum concentration and expression of adiponectin as well as downregulating IL-6 expression. Both fucoxanthin and Undaria pinnatifida may be considered for treating obesity and other diseases related. PMID:27527189

  19. Rhodiolae Kirliowii Radix et Rhizoma and Crataegus pinnatifida Fructus Extracts Effectively Inhibit BK Virus and JC Virus Infection of Host Cells

    Directory of Open Access Journals (Sweden)

    San-Yuan Chen

    2017-01-01

    Full Text Available The human polyomaviruses BK (BKPyV and JC (JCPyV are ubiquitous pathogens long associated with severe disease in immunocompromised individuals. BKPyV causes polyomavirus-associated nephropathy and hemorrhagic cystitis, whereas JCPyV is the causative agent of the fatal demyelinating disease progressive multifocal leukoencephalopathy. No effective therapies targeting these viruses are currently available. The goal of this study was to identify Chinese medicinal herbs with antiviral activity against BKPyV and JCPyV. We screened extracts of Chinese medicinal herbs for the ability to inhibit hemagglutination by BKPyV and JCPyV virus-like particles (VLPs and the ability to inhibit BKPyV and JCPyV binding and infection of host cells. Two of the 40 herbal extracts screened, Rhodiolae Kirliowii Radix et Rhizoma and Crataegus pinnatifida Fructus, had hemagglutination inhibition activity on BKPyV and JCPyV VLPs and further inhibited infection of the cells by BKPyV and JCPyV, as evidenced by reduced expression of viral proteins in BKPyV-infected and JCPyV-infected cells after treatment with Rhodiolae Kirliowii Radix et Rhizoma or Crataegus pinnatifida Fructus extract. The results in this work show that both Rhodiolae Kirliowii Radix et Rhizoma and Crataegus pinnatifida Fructus may be sources of potential antiviral compounds for treating BKPyV and JCPyV infections.

  20. Rhodiolae Kirliowii Radix et Rhizoma and Crataegus pinnatifida Fructus Extracts Effectively Inhibit BK Virus and JC Virus Infection of Host Cells.

    Science.gov (United States)

    Chen, San-Yuan; Teng, Ru-Hsiou; Wang, Meilin; Chen, Pei-Lain; Lin, Mien-Chun; Shen, Cheng-Huang; Chao, Chun-Nun; Chiang, Ming-Ko; Fang, Chiung-Yao; Chang, Deching

    2017-01-01

    The human polyomaviruses BK (BKPyV) and JC (JCPyV) are ubiquitous pathogens long associated with severe disease in immunocompromised individuals. BKPyV causes polyomavirus-associated nephropathy and hemorrhagic cystitis, whereas JCPyV is the causative agent of the fatal demyelinating disease progressive multifocal leukoencephalopathy. No effective therapies targeting these viruses are currently available. The goal of this study was to identify Chinese medicinal herbs with antiviral activity against BKPyV and JCPyV. We screened extracts of Chinese medicinal herbs for the ability to inhibit hemagglutination by BKPyV and JCPyV virus-like particles (VLPs) and the ability to inhibit BKPyV and JCPyV binding and infection of host cells. Two of the 40 herbal extracts screened, Rhodiolae Kirliowii Radix et Rhizoma and Crataegus pinnatifida Fructus, had hemagglutination inhibition activity on BKPyV and JCPyV VLPs and further inhibited infection of the cells by BKPyV and JCPyV, as evidenced by reduced expression of viral proteins in BKPyV-infected and JCPyV-infected cells after treatment with Rhodiolae Kirliowii Radix et Rhizoma or Crataegus pinnatifida Fructus extract. The results in this work show that both Rhodiolae Kirliowii Radix et Rhizoma and Crataegus pinnatifida Fructus may be sources of potential antiviral compounds for treating BKPyV and JCPyV infections.

  1. William Harvey and blood circulation: his epistemological obstacles William Harvey: la circulación sanguínea y algunos de sus obstáculos epistemológicos

    Directory of Open Access Journals (Sweden)

    Carlos Enrique Escobar Gónima

    2006-01-01

    Full Text Available This paper emphasizes on the importance of William Harvey as a precursor of the experimental method in medicine. It describes some of the epistemological obstacles he had to face in the elaboration of his theory of blood circulation, contradicting the galenical theory on the subject that was accepted as a doctrine at his time. Este artículo señala la importancia de William Harvey como precursor del método experimental en medicina. Se mencionan algunos obstáculos teóricos que tuvo que afrontar para elaborar su teoría de la circulación sanguínea, contradiciendo la teoría galénica aceptada como doctrina en su tiempo.

  2. Origins of systems biology in William Harvey's masterpiece on the movement of the heart and the blood in animals.

    Science.gov (United States)

    Auffray, Charles; Noble, Denis

    2009-04-17

    In this article we continue our exploration of the historical roots of systems biology by considering the work of William Harvey. Central arguments in his work on the movement of the heart and the circulation of the blood can be shown to presage the concepts and methods of integrative systems biology. These include: (a) the analysis of the level of biological organization at which a function (e.g. cardiac rhythm) can be said to occur; (b) the use of quantitative mathematical modelling to generate testable hypotheses and deduce a fundamental physiological principle (the circulation of the blood) and (c) the iterative submission of his predictions to an experimental test. This article is the result of a tri-lingual study: as Harvey's masterpiece was published in Latin in 1628, we have checked the original edition and compared it with and between the English and French translations, some of which are given as notes to inform the reader of differences in interpretation.

  3. Assessing cognitive processes related to insomnia: A review and measurement guide for Harvey's cognitive model for the maintenance of insomnia.

    Science.gov (United States)

    Hiller, Rachel M; Johnston, Anna; Dohnt, Hayley; Lovato, Nicole; Gradisar, Michael

    2015-10-01

    Cognitive processes play an important role in the maintenance, and treatment of sleep difficulties, including insomnia. In 2002, a comprehensive model was proposed by Harvey. Since its inception the model has received >300 citations, and provided researchers and clinicians with a framework for understanding and treating insomnia. The aim of this review is two-fold. First, we review the current literature investigating each factor proposed in Harvey's cognitive model of insomnia. Second, we summarise the psychometric properties of key measures used to assess the model's factors and mechanisms. From these aims, we demonstrate both strengths and limitations of the current knowledge of appropriate measurements associated with the model. This review aims to stimulate and guide future research in this area; and provide an understanding of the resources available to measure, target, and resolve cognitive factors that may maintain chronic insomnia. Copyright © 2014 Elsevier Ltd. All rights reserved.

  4. An irresponsible biography of the actor Laurence Harvey: motion pictures, white wine, older women & long thin cigarettes

    OpenAIRE

    Brannon, Matthew

    2015-01-01

    Tiré du site Internet de Onestar Press: "Pocket edition of Laurence Harvey's "irresponsible" biography by Matthew Brannon. From the back cover of the book : Call yourself an actor ? You're not even a bad actor. You can't act at all, you fucking stupid hopeless sniveling little cunt-faced cunty fucking shit-faced arse-hole ... LAURENCE OLIVIER to Laurence Havery from Robert Stephen's "Knight errant : memoirs of a vagabond actor", Hodder and Stoughton, 1995.".

  5. Development of Anatomophysiologic Knowledge Regarding the Cardiovascular System: From Egyptians to Harvey

    Directory of Open Access Journals (Sweden)

    Reinaldo Bulgarelli Bestetti

    2014-12-01

    Full Text Available Our knowledge regarding the anatomophysiology of the cardiovascular system (CVS has progressed since the fourth millennium BC. In Egypt (3500 BC, it was believed that a set of channels are interconnected to the heart, transporting air, urine, air, blood, and the soul. One thousand years later, the heart was established as the center of the CVS by the Hippocratic Corpus in the medical school of Kos, and some of the CVS anatomical characteristics were defined. The CVS was known to transport blood via the right ventricle through veins and the pneuma via the left ventricle through arteries. Two hundred years later, in Alexandria, following the development of human anatomical dissection, Herophilus discovered that arteries were 6 times thicker than veins, and Erasistratus described the semilunar valves, emphasizing that arteries were filled with blood when ventricles were empty. Further, 200 years later, Galen demonstrated that arteries contained blood and not air. With the decline of the Roman Empire, Greco-Roman medical knowledge about the CVS was preserved in Persia, and later in Islam where, Ibn Nafis inaccurately described pulmonary circulation. The resurgence of dissection of the human body in Europe in the 14th century was associated with the revival of the knowledge pertaining to the CVS. The main findings were the description of pulmonary circulation by Servetus, the anatomical discoveries of Vesalius, the demonstration of pulmonary circulation by Colombo, and the discovery of valves in veins by Fabricius. Following these developments, Harvey described blood circulation.

  6. The correspondence and collaboration of Harvey Cushing and Irvine Page: Lessons from the Cleveland Clinic Archives

    Directory of Open Access Journals (Sweden)

    Kalil G Abdullah

    2015-01-01

    Full Text Available Harvey Cushing is well-known as a pioneer of brain surgery and is considered the father of modern neurosurgery. However, Cushing′s interests and contributions extend beyond neurosurgery. Through his determined interdisciplinary collaboration in medicine and biomedical research, Cushing was able to contribute to numerous fields including bacteriology, anesthesiology, and endocrinology. With regards to the latter, Cushing corresponds with Irvine Page, well-known for isolating serotonin, discovering the renin-angiotensin system, and postulating of the mosaic theory of hypertension. In a correspondence spanning 3 years, from January 1933 to April 1936, Cushing and Page collaborated to discover a substance responsible for hypertension. In this historical article, the authors review the letters to highlight the collaborative efforts between leaders in disparate fields driven by the scientific curiosity. As national research agencies are focusing their funds toward collaborative and interdisciplinary research, it is interesting to note the historical communication among the scientific leaders that led to discoveries in the respective fields.

  7. Harvey Cushing, Gordon Holmes, and the neurological lessons of World War I.

    Science.gov (United States)

    Lepore, F E

    1994-07-01

    As the gunshots that fatally wounded Archduke Franz Ferdinand and Countess Sophie of Austria resounded from Sarajevo across Europe to become the deafening roar of artillery on the Western Front in August 1914, Harvey Williams Cushing was the world's preeminent neurosurgeon and Gordon Morgan Holmes was arguably the foremost neurologist in the world. The 45-year-old Cushing, and Holmes just 38 years old, would strive to respond to the neurological challenges of World War I. They distinguished themselves amidst the redoubtable efforts of workers such as Walter Cannon, George Riddoch, Charles Sherrington, Henry Head, Victor Horsley, Walther Poppelreuter, and Robert Barany. Even the intense martial spirit of the time would be held in abeyance by the contributions of such men of science, as when the intercession of Prince Carl of Sweden secured the release of Barany from a Russian prisoner-of-war camp and allowed him to accept the 1916 Nobel Prize for his exposition of vestibular physiology. Such respite from the brutality of war was all too brief, and if we are to grasp the significance of the different approaches of Holmes and Cushing to the terrible problems of World War I, we must examine some of the harsh medical realities that they confronted in the "war to end all wars."

  8. Development of Anatomophysiologic Knowledge Regarding the Cardiovascular System: From Egyptians to Harvey

    Energy Technology Data Exchange (ETDEWEB)

    Bestetti, Reinaldo Bulgarelli, E-mail: rbestetti44@gmail.com; Restini, Carolina Baraldi A.; Couto, Lucélio B. [Universidade de Ribeirão Preto - UNAERP, Ribeirão Preto, SP (Brazil)

    2014-12-15

    Our knowledge regarding the anatomophysiology of the cardiovascular system (CVS) has progressed since the fourth millennium BC. In Egypt (3500 BC), it was believed that a set of channels are interconnected to the heart, transporting air, urine, air, blood, and the soul. One thousand years later, the heart was established as the center of the CVS by the Hippocratic Corpus in the medical school of Kos, and some of the CVS anatomical characteristics were defined. The CVS was known to transport blood via the right ventricle through veins and the pneuma via the left ventricle through arteries. Two hundred years later, in Alexandria, following the development of human anatomical dissection, Herophilus discovered that arteries were 6 times thicker than veins, and Erasistratus described the semilunar valves, emphasizing that arteries were filled with blood when ventricles were empty. Further, 200 years later, Galen demonstrated that arteries contained blood and not air. With the decline of the Roman Empire, Greco-Roman medical knowledge about the CVS was preserved in Persia, and later in Islam where, Ibn Nafis inaccurately described pulmonary circulation. The resurgence of dissection of the human body in Europe in the 14th century was associated with the revival of the knowledge pertaining to the CVS. The main findings were the description of pulmonary circulation by Servetus, the anatomical discoveries of Vesalius, the demonstration of pulmonary circulation by Colombo, and the discovery of valves in veins by Fabricius. Following these developments, Harvey described blood circulation.

  9. Callan-Giddings-Harvey-Strominger vacuum in loop quantum gravity and singularity resolution

    Science.gov (United States)

    Corichi, Alejandro; Olmedo, Javier; Rastgoo, Saeed

    2016-10-01

    We study here a complete quantization of a Callan-Giddings-Harvey-Strominger vacuum model following loop quantum gravity techniques. Concretely, we adopt a formulation of the model in terms of a set of new variables that resemble the ones commonly employed in spherically symmetric loop quantum gravity. The classical theory consists of two pairs of canonical variables plus a scalar and diffeomorphism (first class) constraints. We consider a suitable redefinition of the Hamiltonian constraint such that the new constraint algebra (with structure constants) is well adapted to the Dirac quantization approach. For it, we adopt a polymeric representation for both the geometry and the dilaton field. On the one hand, we find a suitable invariant domain of the scalar constraint operator, and we construct explicitly its solution space. There, the eigenvalues of the dilaton and the metric operators cannot vanish locally, allowing us to conclude that singular geometries are ruled out in the quantum theory. On the other hand, the physical Hilbert space is constructed out of them, after group averaging the previous states with the diffeomorphism constraint. In turn, we identify the standard observable corresponding to the mass of the black hole at the boundary, in agreement with the classical theory. We also construct an additional observable on the bulk associated with the square of the dilaton field, with no direct classical analog.

  10. In-situ stresses in the Southern Perth Basin at the GSWA Harvey-1 well site

    Science.gov (United States)

    Rasouli, Vamegh 14Pervukhina, Marina 2Müller, Tobias M. 2Pevzner, Roman

    2013-11-01

    Knowledge of orientations and magnitudes of present-day stresses is important for different applications including fault reactivation, borehole stability and CO2 injection studies. As part of the West Hub Carbon Capture and Storage project, the GSWA Harvey-1 well was drilled in early 2012. It is located ~115km south of Perth and is used to assess the suitability for CO2 underground storage. The aim of this study is to estimate the mechanical properties and state of stress fields in the Southern Perth Basin. The analysis is based on the newly acquired log and VSP data and results of a rock mechanical model including vertical profiles of elastic and strength properties as well as identified breakout zones. The results indicate that the stress regime in the region is dominantly strike-slip. It changes to a reverse faulting system at shallow depths of below ~900m. Stress field orientation is obtained from borehole breakout analysis. The average azimuth of the maximum horizontal stress is 106° and the standard deviation is 10°. This direction of the maximum horizontal stress is broadly consistent with the east-west direction earlier reported for the Perth Basin.

  11. Harvey Cushing’s Ghosts: Death and Hauntings in Modern Medicine

    Science.gov (United States)

    Shin, Paul

    2011-01-01

    The passing of Yale School of Medicine’s 2010 Bicentennial occasions a moment of reflecting on the past, present, and future of medical education and research at Yale and beyond. Last June, a ribbon-cutting ceremony inaugurated the opening of the Cushing Center in the Cushing-Whitney Medical Library. Named after Harvey Cushing, an early 20th-century neurosurgeon and former Yale College alum, the dual education/exhibition space now houses hundreds of gross brain specimens constituting the Cushing Tumor Registry. Originally a personal collection, Cushing donated his numerous medical specimens, photographs, and other medical relics from his deathbed, relinquishing the brains to Yale only under the condition that a suitable space be erected to preserve the many specimens. Some 70 years later and after nearly being destroyed, Cushing’s wish is fully realized: The once desiccated, hidden brains have been painstakingly restored and are now on view in the Cushing Center. The brains express Cushing’s singular and spectral worldview as a surgeon, artist, athlete, soldier, book collector, and historian. PMID:21698039

  12. Spermatozoid life-span of two brown seaweeds, Saccharina japonica and Undaria pinnatifida, as measured by fertilization efficiency

    Institute of Scientific and Technical Information of China (English)

    LI Jing; PANG Shaojun; LIU Feng; SHAN Tifeng; GAO Suqin

    2013-01-01

    During sexual reproduction of seaweeds,spermatozoid (sperm) discharge is triggered by chemical messengers (pheromones) released by the female gametes.The chemotactic ability of the sperm ensures fertilization success.Using unialgal male and female gametophyte material under designated standard gametogenesis testing (SGT) conditions,the potential life-span of the sperm of two seaweeds,Saccharinajaponica and Undaria pinnatifida,was assessed by their ability to fertilize eggs.Results show that within 20-30 min after being discharged,sperm of both species could complete fertilization without an apparent decline in fertilization rate.Although fertilization rate 60-120 min after sperm discharge dropped significantly in both species,some sperm were viable enough to fertilize the eggs.In S.japonica,at 12℃,some sperm were able to fertilize eggs up to 12 h after discharge.In both species,egg discharge rates (EDR) in the male and female mixed positive controls were significantly higher than those of all the sperm-testing groups.Doubling the seeded male gametophytes of S.japonica in the SGT tests significantly increased the EDR,further confirming the effect of the presence of the male on the female in terms of facilitating egg discharge from oogonia.

  13. Antioxidant activity and components of a traditional Chinese medicine formula consisting of Crataegus pinnatifida and Salvia miltiorrhiza.

    Science.gov (United States)

    Chen, Cheng-Yu; Li, Hua; Yuan, Ya-Nan; Dai, Hui-Qing; Yang, Bin

    2013-05-10

    The aims of this study were to evaluate the antioxidant activity and to identify the antioxidant components of a traditional Chinese medicine formula consisting of a combination of Shanzha (the fruit of Crataegus pinnatifida Bge. var. major N.E.Br., SZ) and Danshen (the root of Salvia miltiorrhiza Bge., DS). This medicine is extensively used to treat cardiovascular disease. Twelve samples extracted and fractionated from SZ, DS and the formula (SZ+DS) were analyzed. The concentrations of eight phenolic compounds were determined by high performance liquid chromatography. Oxygen radical absorbance capacity (ORAC) assay and 1,1-diphenyl-2-picrylhydrazyl assay were conducted to explore the antioxidant activities of the samples and of the 15 phenolic compounds detected. Correlation analysis of the antioxidant activity of herb samples and their phenolic components was performed. The main phenolic component in all SZ+DS samples was salvianolic acid B, which exhibited strong antioxidant activity (ORAC value: 16.73 ± 2.53, IC50 value: 8.80 ± 0.06 μM) compared with the other phenolic compounds. For all samples, there was a positive relationship between their total phenolic components and their antioxidant activities. Phenolic compounds were the bioactive components of the herb samples, and salvianolic acid B was identified as the main bioactive compound in the SZ+DS formula.

  14. The natural compound fucoidan from New Zealand Undaria pinnatifida synergizes with the ERBB inhibitor lapatinib enhancing melanoma growth inhibition.

    Science.gov (United States)

    Thakur, Varsha; Lu, Jun; Roscilli, Giuseppe; Aurisicchio, Luigi; Cappelletti, Manuela; Pavoni, Emiliano; White, William Lindsey; Bedogni, Barbara

    2017-03-14

    Melanoma remains one of the most aggressive and therapy-resistant cancers. Finding new treatments to improve patient outcomes is an ongoing effort. We previously demonstrated that melanoma relies on the activation of ERBB signaling, specifically of the ERBB3/ERBB2 cascade. Here we show that melanoma tumor growth is inhibited by 60% over controls when treated with lapatinib, a clinically approved inhibitor of ERBB2/EGFR. Importantly, tumor growth is further inhibited to 85% when the natural compound fucoidan from New Zealand U. pinnatifida is integrated into the treatment regimen. Fucoidan not only enhances tumor growth inhibition, it counteracts the morbidity associated with prolonged lapatinib treatment. Fucoidan doubles the cell killing capacity of lapatinib. These effects are associated with a further decrease in AKT and NFκB signaling, two key pathways involved in melanoma cell survival. Importantly, the enhancing cell killing effects of fucoidan can be recapitulated by inhibiting ERBB3 by either a specific shRNA or a novel, selective ERBB3 neutralizing antibody, reiterating the key roles played by this receptor in melanoma. We therefore propose the use of lapatinib or specific ERBB inhibitors, in combination with fucoidan as a new treatment of melanoma that potentiates the effects of the inhibitors while protecting from their potential side effects.

  15. Circadian rhythms in the growth and reproduction of the brown alga Undaria pinnatifida and gametogenesis under different photoperiods

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zhihuai; PANG Shaojun

    2007-01-01

    Circadian growth rhythm of the juvenile sporophyte of the brown alga Undaria pinnatifida was measured with the computer-aided image analysis system in constant florescent white light under constant temperature ( 10 ℃ ). The growth rhythm persisted for 4 d in constant light with a free-running period of 25.6 h. Egg release from filamentous gametophytes pre-cultured in the light - dark regime was evaluated for six consecutive days at fixed time intervals in constant white light and 12 h light per day. Egg release rhythm persisted for 3 d in both regimes, indicating the endogenous nature. Temporal scale of egg release and gametogenesis in 18, 16, 12 and 8 h light per day were evaluated respectively using vegetatively propagated filamentous gametophytes. Egg release occurred 2 h after the onset of dark phase and peaked at midnight. Evaluation of the rates of oogonium formation, egg release or fertilization revealed no significant differences in four light-dark regimes, indicating the great plasticity of sexual reproduction. No photoperiodic effect in gametogenesis in terms of oogonium formation and egg release was found, but fertilization in short days was significantly higher than in long days. Results of this investigation further confirmed the general occurrence of circadian rhythms in intertidal seaweed species.

  16. Effects of Undaria pinnatifida, Himanthalia elongata and Porphyra umbilicalis extracts on in vitro α-glucosidase activity and glucose diffusion

    Directory of Open Access Journals (Sweden)

    Adriana R. Schultz Moreira

    2014-06-01

    Full Text Available Background: Seaweeds are good sources of dietary fibre, which can influence glucose uptake and glycemic control. Objective: To investigate and compare the in vitro inhibitory activity of different extracts from Undaria pinnatifida (Wakame, Himanthalia elongata (Sea spaghetti and Porphyra umbilicalis (Nori on α-glucosidase activity and glucose diffusion. Methods: The in vitro effects chloroform-, ethanol- and water-soluble extracts of the three algae were assayed on α-glucosidase activity and glucose diffusion through membrane. Principal Components Analysis (PCA was applied to identify patterns in the data and to discriminate which extract will show the most proper effect. Results: Only water extracts of Sea spaghetti possessed significant in vitro inhibitory effects on α-glucosidase activity (26.2% less mmol/L glucose production than control, p < 0.05 at 75 min. PCA distinguished Sea spaghetti effects, supporting that soluble fibre and polyphenols were involved. After 6 h, Ethanol-Sea spaghetti and water-Wakame extracts exerted the highest inhibitory effects on glucose diffusion (65.0% and 60.2% vs control, respectively. This extracts displayed the lowest slopes for glucose diffusion-time lineal adjustments (68.2% and 62.8% vs control, respectively. Conclusions: The seaweed hypoglycemic effects appear multi-faceted and not necessarily concatenated. According to present results, ethanol and water extracts of Sea spaghetti, and water extracts of Wakame could be useful for the development of functional foods with specific hypoglycemic properties.

  17. Observations on fish grazing of the cultured kelps Undaria pinnatifida and Saccharina latissima (Phaeophyceae, Lam inariales in Spanish Atlantic waters

    Directory of Open Access Journals (Sweden)

    César Peteiro

    2012-09-01

    Full Text Available Despite the great importance of grazing by herbivorous fishes in the marine environment, the knowledge of this phenomenon on seaweeds cultivationis very limited.Indeed, there is not available information on the effects of fish grazing in the farming of economically valuable kelps.During an investigation of the cultivation of commercial kelps Undaria pinnatifida and Saccharina latissima in North Western Atlantic coast of Spain (Galicia,it was found that grazing by fishes was sometimes responsible for removing of algal’s material from culture ropes.Fish grazing were generally rare and with a minor influence, usually its adverse effects are limited to a small decrease in the yield in some culture ropes,however,in some cases,it can also involve the lost of virtually the entire crop of culture rope.Most of herbivore grazing was associated to sparid fishes such as bogue(Boops boops,and salema(Sarpasalpa. Preferably, herbivorous fishes consumed blade of both cultured kelps when they were still young fronds(juvenile stage of algae. Indeed, blade of adult fronds was clearly less affected, and in S.latissima adults there was even not observed any fish grazing effects.Herein, different biotic and abiotic factors are discussed as possible causes of the influence of fish grazing on cultured kelps.

  18. Kinetics and molecular docking studies of fucosterol and fucoxanthin, BACE1 inhibitors from brown algae Undaria pinnatifida and Ecklonia stolonifera.

    Science.gov (United States)

    Jung, Hyun Ah; Ali, Md Yousof; Choi, Ran Joo; Jeong, Hyong Oh; Chung, Hae Young; Choi, Jae Sue

    2016-03-01

    Since the action of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is strongly correlated with the onset of Alzheimer's disease (AD), the development of BACE1 inhibitors as therapeutic agents is being vigorously pursued. In our ongoing research aimed at identifying anti-AD remedies derived from maritime plants, we evaluated the BACE1 inhibitory activities of fucosterol and fucoxanthin from Ecklonia stolonifera and Undaria pinnatifida. In vitro anti-AD activities were performed via BACE1 inhibition assays, as well as enzyme kinetic and molecular docking predictions. Based on enzyme-based assays, fucosterol and fucoxanthin showed noncompetitive and mixed-type inhibition, respectively, against BACE1. In addition, docking simulation results demonstrated that the Lys224 residue of BACE1 interacted with one hydroxyl group of fucosterol, while two additional BACE1 residues (Gly11 and Ala127) interacted with two hydroxyl groups of fucoxanthin. Moreover, the binding energy of fucosterol and fucoxanthin was negative (-10.1 and -7.0 kcal/mol), indicating that hydrogen bonding may stabilize the open form of the enzyme and potentiate tight binding of the active site of BACE1, resulting in more effective BACE1 inhibition. The results suggest that fucosterol and fucoxanthin may be used beneficially in the treatment of AD and provide potential guidelines for the design of new BACE1 inhibitors.

  19. Anti-metastasis effect of fucoidan from Undaria pinnatifida sporophylls in mouse hepatocarcinoma Hca-F cells.

    Directory of Open Access Journals (Sweden)

    Peisheng Wang

    Full Text Available Metastasis is one of the major causes of cancer-related death. It is a complex biological process involving multiple genes, steps, and phases. It is also closely connected to many biological activities of cancer cells, such as growth, invasion, adhesion, hematogenous metastasis, and lymphatic metastasis. Fucoidan derived from Undaria pinnatifida sporophylls (Ups-fucoidan is a sulfated polysaccharide with more biological activities than other fucoidans. However, there is no information on the effects of Ups-fucoidan on tumor invasion and metastasis. We used the mouse hepatocarcinoma Hca-F cell line, which has high invasive and lymphatic metastasis potential in vitro and in vivo, to examine the effect of Ups-fucoidan on cancer cell invasion and metastasis. Ups-fucoidan exerted a concentration- and time-dependent inhibitory effect on tumor metastasis in vivo and inhibited Hca-F cell growth, migration, invasion, and adhesion capabilities in vitro. Ups-fucoidan inhibited growth and metastasis by downregulating vascular endothelial growth factor (VEGF C/VEGF receptor 3, hepatocyte growth factor/c-MET, cyclin D1, cyclin-dependent kinase 4, phosphorylated (p phosphoinositide 3-kinase, p-Akt, p-extracellular signal regulated kinase (ERK 1/2, and nuclear transcription factor-κB (NF-κB, and suppressed adhesion and invasion by downregulating L-Selectin, and upregulating protein levels of tissue inhibitor of metalloproteinases (TIMPs. The results suggest that Ups-fucoidan suppresses Hca-F cell growth, adhesion, invasion, and metastasis capabilities and that these functions are mediated through the mechanism involving inactivation of the NF-κB pathway mediated by PI3K/Akt and ERK signaling pathways.

  20. Anti-metastasis effect of fucoidan from Undaria pinnatifida sporophylls in mouse hepatocarcinoma Hca-F cells.

    Science.gov (United States)

    Wang, Peisheng; Liu, Zhichao; Liu, Xianli; Teng, Hongming; Zhang, Cuili; Hou, Lin; Zou, Xiangyang

    2014-01-01

    Metastasis is one of the major causes of cancer-related death. It is a complex biological process involving multiple genes, steps, and phases. It is also closely connected to many biological activities of cancer cells, such as growth, invasion, adhesion, hematogenous metastasis, and lymphatic metastasis. Fucoidan derived from Undaria pinnatifida sporophylls (Ups-fucoidan) is a sulfated polysaccharide with more biological activities than other fucoidans. However, there is no information on the effects of Ups-fucoidan on tumor invasion and metastasis. We used the mouse hepatocarcinoma Hca-F cell line, which has high invasive and lymphatic metastasis potential in vitro and in vivo, to examine the effect of Ups-fucoidan on cancer cell invasion and metastasis. Ups-fucoidan exerted a concentration- and time-dependent inhibitory effect on tumor metastasis in vivo and inhibited Hca-F cell growth, migration, invasion, and adhesion capabilities in vitro. Ups-fucoidan inhibited growth and metastasis by downregulating vascular endothelial growth factor (VEGF) C/VEGF receptor 3, hepatocyte growth factor/c-MET, cyclin D1, cyclin-dependent kinase 4, phosphorylated (p) phosphoinositide 3-kinase, p-Akt, p-extracellular signal regulated kinase (ERK) 1/2, and nuclear transcription factor-κB (NF-κB), and suppressed adhesion and invasion by downregulating L-Selectin, and upregulating protein levels of tissue inhibitor of metalloproteinases (TIMPs). The results suggest that Ups-fucoidan suppresses Hca-F cell growth, adhesion, invasion, and metastasis capabilities and that these functions are mediated through the mechanism involving inactivation of the NF-κB pathway mediated by PI3K/Akt and ERK signaling pathways.

  1. Effects of Undaria pinnatifida, Himanthalia elongata and Porphyra umbilicalis extracts on in vitro α-glucosidase activity and glucose diffusion.

    Science.gov (United States)

    Schultz Moreira, Adriana R; Garcimartín, Alba; Bastida, Sara; Jiménez-Escrig, Antonio; Rupérez, Pilar; Green, Brian D; Rafferty, Eamon; Sánchez-Muniz, Francisco J; Benedí, Juana

    2014-06-01

    Antecedentes: Las algas son importante fuente alimentaria de fibra dietética y puede influir sobre la absorción de glucosa y el control glucémico. Objetivo: Evaluar y comparar in vitro los efectos de diferentes extractos de las algas Undaria pinnatifida (Wakame), Himanthalia elongata (Espagueti de mar) y Porphyra umbilicalis (Nori) sobre la actividad enzimática -glucosidasa y la difusión de glucosa. Métodos: Se estudiaron los efectos de los extractos clorofórmicos, etánólicos y acuosos de las tres algas sobre la actividad -glucosidasa y la difusión de glucosa a través de una membrana de diálisis. Se aplicó a los resultados un análisis de los componentes principales (PCA) para identificar posibles patrones de composición y seleccionar el extracto que mejores propiedades posea. Resultados: El extracto acuoso de Espagueti de mar inhibió de forma significativa la actividad -glucosidasa (26,2% menos liberación de glucosa, p glucosa, el extracto etanólico de Espagueti de mar y el acuoso de Wakame mostraron un mayor efecto inhibidor después de 6 horas (65% y 60,2% vs control, respectivamente) y las menores pendientes en los ajustes lineales difusión de glucosa- tiempo (68,2% y 62,8% vs control respectivamente). Conclusiones: Los resultados de los diferentes extractos sugieren que los efectos hipogluceminates de las algas son variados y no están necesariamente concatenados. Los extractos acuosos y etanólicos de Espagueti de mar y los acuosos de Wakame parecen los más adecuados para el desarrollo de alimentos funcionales con propiedades hipoglucemiantes.

  2. The portraiture of William Harvey (1578-1657) unveiled by the detective work of Geoffrey Keynes (1887-1983) and Alex Sakula (1917-2003).

    Science.gov (United States)

    James, D Geraint

    2005-05-01

    In November 1948, Sir Geoffrey Keynes exhibited the only known portrait of William Harvey in mid-life. The recovery of this rare portrait was due to Keynes's detective work at visits to Rolls Park in Essex. Dr Alex Sakula discovered the Betchworth portraits of the Harvey family by accident when he was invited to visit a patient, Major General Goulburn, at Betchworth in Surrey. After much research work Sakula was able to mount an informative exhibition at the Royal College of Physicians. Sakula also reminded us of Eliab Harvey (1758-1830), William's descendant, captain of the Téméraire at the Battle of Trafalgar; the year 2005 marks the bicentenary.

  3. Food Byproducts as a New and Cheap Source of Bioactive Compounds: Lignans with Antioxidant and Anti-inflammatory Properties from Crataegus pinnatifida Seeds.

    Science.gov (United States)

    Huang, Xiao-Xiao; Bai, Ming; Zhou, Le; Lou, Li-Li; Liu, Qing-Bo; Zhang, Yan; Li, Ling-Zhi; Song, Shao-Jiang

    2015-08-19

    During the process of manufacturing hawthorn (Crataegus pinnatifida) juice and jam, a significant quantity of byproducts (leaves, seeds) is generated. The antioxidant and anti-inflammatory bioassay-guided fractionation of the extract of hawthorn seeds has led to the isolation of eight new lignans, hawthornnins A-H (1-8), and seven known analogues (9-15). Their structures were elucidated by spectroscopic techniques, including 1D and 2D NMR and CD spectra. The radical-scavenging effects of all isolated compounds were investigated. 1-6 and 8 showed moderate activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH), whereas 1-6 and 14 displayed good 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) free radical-scavenging activities that were even more potent than that of trolox. In addition, all isolates were evaluated for their anti-inflammatory activities by detecting the nitric oxide (NO) and tumor necrosis factor α (TNF-α) production by the LPS-induced murine macrophage cell line RAW264.7, and compounds 1-7, 13, and 14 exhibited potent inhibition of NO and TNF-α production. The structure-activity relationships of isolated lignans were also examined, and the results obtained show that C. pinnatifida seeds can be regarded as a potential new and cheap source of antioxidants and inflammation inhibitors.

  4. Major triterpenoids in Chinese hawthorn "Crataegus pinnatifida" and their effects on cell proliferation and apoptosis induction in MDA-MB-231 cancer cells.

    Science.gov (United States)

    Wen, Lingrong; Guo, Ruixue; You, Lijun; Abbasi, Arshad Mehmood; Li, Tong; Fu, Xiong; Liu, Rui Hai

    2017-02-01

    The cytotoxicity and antiproliferative effect of phytochemicals presenting in the fruits of Chinese hawthorn (Crataegus pinnatifida) were evaluated. Shanlihong (Crataegus pinnatifida Bge. var. major N.E.Br.) variety possessed significant levels of flavonoids and triterpenoids, and showed potent antiproliferative effect against HepG2, MCF-7 and MDA-MB- 231 human cancer cells lines. Triterpenoids-enriched fraction (S9) prepared by Semi-preparative HPLC, and its predominant ingredient ursolic acid (UA) demonstrated remarkably antiproliferative activities for all the tested cancer cell lines. DNA flow cytometric analysis showed that S9 fraction and UA significantly induced G1 arrest in MDA-MB-231 cells in a dose-dependent manner. Western blotting analysis revealed that S9 fraction and UA significantly induced PCNA, CDK4, and Cyclin D1 downregulation in MDA-MB-231 cells, followed by p21(Waf1/Cip1) up-regulation. Additionally, flow cytometer and DNA ladder assays indicated that S9 fraction and UA significantly induced MDA-MB-231 cells apoptosis. Mitochondrial death pathway was involved in this apoptosis as significantly induced caspase-9 and caspase-3 activation. These results suggested that triterpenoids-enriched fraction and UA exhibited antiproliferative activity through the cell cycle arrest and apoptosis induction, and was majorly responsible for the potent anticancer activity of Chinese hawthorn. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. Fucoidan Derived from Undaria pinnatifida Induces Apoptosis in Human Hepatocellular Carcinoma SMMC-7721 Cells via the ROS-Mediated Mitochondrial Pathway

    Directory of Open Access Journals (Sweden)

    Lin Hou

    2013-06-01

    Full Text Available Fucoidans, fucose-enriched sulfated polysaccharides isolated from brown algae and marine invertebrates, have been shown to exert anticancer activity in several types of human cancer, including leukemia and breast cancer and in lung adenocarcinoma cells. In the present study, the anticancer activity of the fucoidan extracted from the brown seaweed Undaria pinnatifida was investigated in human hepatocellular carcinoma SMMC-7721 cells, and the underlying mechanisms of action were investigated. SMMC-7721 cells exposed to fucoidan displayed growth inhibition and several typical features of apoptotic cells, such as chromatin condensation and marginalization, a decrease in the number of mitochondria, and in mitochondrial swelling and vacuolation. Fucoidan-induced cell death was associated with depletion of reduced glutathione (GSH, accumulation of high intracellular levels of reactive oxygen species (ROS, and accompanied by damage to the mitochondrial ultrastructure, depolarization of the mitochondrial membrane potential (MMP, Δψm and caspase activation. Moreover, fucoidan led to altered expression of factors related to apoptosis, including downregulating Livin and XIAP mRNA, which are members of the inhibitor of apoptotic protein (IAP family, and increased the Bax-to-Bcl-2 ratio. These findings suggest that fucoidan isolated from U. pinnatifida induced apoptosis in SMMC-7721 cells via the ROS-mediated mitochondrial pathway.

  6. Major Harvey Cushing's difficulties with the British and American armies during World War I.

    Science.gov (United States)

    Carey, Michael E

    2014-08-01

    This historical review explores Harvey Cushing's difficulties with both the British and American armies during his World War I service to definitively examine the rumor of his possible court martial. It also provides a further understanding of Cushing the man. While in France during World War I, Cushing was initially assigned to British hospital units. This service began in May 1917 and ended abruptly in May 1918 when the British cashiered him for repeated censorship violations. Returning to American command, he feared court martial. The army file on this matter (retrieved from the United States National Archives) indicates that US Army authorities recommended that Cushing be reprimanded and returned to the US for his violations. The army carried out neither recommendation, and no evidence exists that a court martial was considered. Cushing's army career and possible future academic life were protected by the actions of his surgical peers and Merritte Ireland, Chief Surgeon of the US Army in France. After this censorship episode, Cushing was made a neurosurgical consultant but was also sternly warned that further rule violations would not be tolerated by the US Army. Thereafter, despite the onset of a severe peripheral neuropathy, probably Guillian Barré's syndrome, Cushing was indefatigable in ministering to neurosurgical needs in the US sector in France. Cushing's repeated defying of censorship regulations reveals poor judgment plus an initial inability to be a "team player." The explanations he offered for his censorship violations showed an ability to bend the truth. Cushing's war journal is unclear as to exactly what transpired between him and the British and US armies. It also shows no recognition of the help he received from others who were instrumental in preventing his ignominious removal from service in France. Had that happened, his academic future and ability to train future neurosurgical leaders may have been seriously threatened. Cushing's foibles

  7. Reconstrucción estructuralista de la teoría del movimiento circular de la sangre, de William Harvey

    Directory of Open Access Journals (Sweden)

    Joaquín Barutta

    2012-01-01

    Full Text Available En las investigaciones sobre fisiología cardiovascular desarrolladas por William Harvey es posible distinguir entre dos teorías que responden a preguntas diferentes. La primera de ellas, que denominamos teoría del movimiento circular de la sangre, intenta dar una respuesta al problema sobre la cantidad de sangre que se mueve dentro del sistema. La segunda pretende dar cuenta de las causas de que la sangre se mueva y la denominamos teoría de las causas del movimiento de la sangre. En este trabajo, presentamos una reconstrucción estructuralista de la primera de éstas, y mostramos que posee todos los componentes considerados esenciales para cualquier teoría, de acuerdo con la concepción estructuralista de la ciencia.In the researches on cardiovascular physiology conducted by William Harvey it is possible to distinguish between two theories answering to different questions. The first, which we call the theory of the circular motion of the blood, tries to give a solution to the problem of the quantity of blood that moves within the system. The second attempts to give an account of the causes that makes the blood move, and we call it the theory of the causes of blood movement. In this article, we present a structuralist reconstruction of the first theory, and show that it possesses all the components that are considered essential for any theory, according to the structuralist view of science.

  8. 裙带菜和海带提取液体外抑瘤实验研究%The Inhibiting Effect on Tumor Cells in vitro by Two Common Seaweed Extracts

    Institute of Scientific and Technical Information of China (English)

    高淑清; 单保恩; 张兵; 赵泽贞

    2004-01-01

    裙带菜(Undaria pinnatifida(Harv.)Suringar)和海带(Laminaria)均为褐藻门昆布属,生活在海洋里,可用于防治缺碘性甲状腺肿、动脉硬化、高脂血症、高血压等,本实验研究其对肿瘤细胞增殖的体外抑制作用。

  9. Harvey Cushing's case series of trigeminal neuralgia at the Johns Hopkins Hospital: a surgeon's quest to advance the treatment of the 'suicide disease'.

    NARCIS (Netherlands)

    Adams, H.; Pendleton, C.; Latimer, K.; Cohen-Gadol, A.A.; Carson, B.S.; Quinones-Hinojosa, A.

    2011-01-01

    BACKGROUND: A review of Dr. Harvey Cushing's surgical cases at the Johns Hopkins Hospital provided insight into his early work on trigeminal neuralgia (TN). There was perhaps no other affliction that captured his attention in the way that TN did, and he built a remarkable legacy of successful treatm

  10. The role of Harvey Cushing and Walter Dandy in the evolution of modern neurosurgery in the Netherlands, illustrated by their correspondence Historical vignette

    NARCIS (Netherlands)

    Groen, Rob J. M.; Koehler, Peter J.; Kloet, Alfred

    The development of modern neurosurgery in the Netherlands, which took place in the 1920s, was highly influenced by the personal involvement of both Harvey Cushing and Walter Dandy, each in his own way. For the present article, the authors consulted the correspondence (kept at the Cushing/Whitney

  11. 75 FR 22864 - In the Matter of CAN USA, Inc., Harvey, Louisiana; General License Pursuant to 10 CFR 150.20...

    Science.gov (United States)

    2010-04-30

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION In the Matter of CAN USA, Inc., Harvey, Louisiana; General License Pursuant to 10 CFR 150.20; Confirmatory Order (Effective Immediately) I CAN USA, Inc. (CAN USA or Licensee) is the holder of State...

  12. The role of Harvey Cushing and Walter Dandy in the evolution of modern neurosurgery in the Netherlands, illustrated by their correspondence Historical vignette

    NARCIS (Netherlands)

    Groen, Rob J. M.; Koehler, Peter J.; Kloet, Alfred

    2013-01-01

    The development of modern neurosurgery in the Netherlands, which took place in the 1920s, was highly influenced by the personal involvement of both Harvey Cushing and Walter Dandy, each in his own way. For the present article, the authors consulted the correspondence (kept at the Cushing/Whitney Med

  13. Correlation between MSCTEEvaluation of Crohn's Disease Activity Index and the Harvey-Bradshaw Index%MSCTE评价Crohn病活动度指数与Harvey-Bradshaw指数的相关性研究

    Institute of Scientific and Technical Information of China (English)

    叶文卫; 张燕红; 李忠荣; 郭天畅; 程伟光; 陈毅斌; 刘琴

    2016-01-01

    目的:探讨MSCTE评价克罗恩病(Crohn)活动指数(CDII)与Harvey-Bradshaw指数(HBI)的相关性。方法:选取2014年7月至2016年3月两家医院病理证实的30例CD患者为研究对象,HBI评分后行MSCTE检查并根据CD影像指数评分表评价Crohn病活动指数,比较CDII与HBI在CD活动度分级差异及相关性。结果:CDII与HBI在CD各分级中比较差异无统计学意义(P>0.05)。Spearman相关分析得出CDII和HBI在CD活动度各级中均有显著相关性。结论:CDII与HBI呈显著相关性,具有较高临床价值。%Objective: To investigateMulti-slice Computer Tomography Enterography(MSCTE)evaluate Crohn's disease activity index (CDII) and the Harvey-Bradshaw Index (HBI) correlation. Method: Select fromJuly 2014 to March 2016two hospitals confirmed by pathology CD 30 patients for the study,after HBI score, MSCTE scan, score table to evaluate Crohn's disease activity index based on CD image index, comparison CDII and HBI difference CDactivity classification and correlation. Conclusion: CDII and HBI difference in the classification of each CD was not statistically significant (P>0.05).Spearman correlation analysis CDII and HBI in CD activity at all levels were significantly correlated.Result: CDII and HBI was significantly correlated with a higher clinical value.

  14. Effects of an aqueous extract of Crataegus pinnatifida Bge. var. major N.E.Br. fruit on experimental atherosclerosis in rats.

    Science.gov (United States)

    Zhang, Jianyong; Liang, Rixin; Wang, Lan; Yan, Renyi; Hou, Rui; Gao, Shuangrong; Yang, Bin

    2013-07-09

    Atherosclerosis (AS) can result in severe cardiovascular diseases. Early indications of AS include disorders in lipid metabolism, inflammatory responses, and endothelial dysfunction. Statins are the preferred drugs for stabilizing atherosclerotic plaques because of their lipid-lowering, anti-inflammation and endothelial-protection activities. However, they can exhibit side effects and are effective in only one-third of patients. Many natural products (especially traditional Chinese medicines (TCMs)) possessing similar lipid-lowering, anti-inflammation and antioxidant activities are of interest in many studies exploring new AS drug therapy. The widely distributed hawthorn is used to prevent and cure heart disease not only in China but also in the United States and several European countries. For example, the fruit of Crataegus pinnatifida Bge. and Crataegus pinnatifida Bge. var. major N.E.Br. (a commonly used hawthorn fruit in China) is used in combination with other TCMs to treat AS. Studies have also shown that the water extracts of these two hawthorn fruits are effective against hyperlipidemia by lowering lipid levels, reducing endothelial dysfunction, and inhibiting inflammation. The aim of the study is to investigate the effect and possible mechanisms of the aqueous extract of Crataegus pinnatifida var. major on AS rats. The fruit of Crataegus pinnatifida var. major was extracted with 70% ethanol; the ethanol extract was chromatographed on a D101 macroporous resin to obtain a sugar-free aqueous extract (AECP). Atherosclerotic rats were fed a high-fat diet and injected with vitamin D3 and ovalbumin. Rats were divided into five groups: normal, model, model plus simvastatin, model plus low-dose AECP, and model plus high-dose AECP. AECP and simvastatin were administered (via the intragastric route) to AECP groups and the simvastatin group. For normal and model groups, water was given for 4 weeks. After 12 weeks, levels of total cholesterol (TC), triglyceride (TG

  15. Influence of pyrolysis temperature on characteristics and phosphate adsorption capability of biochar derived from waste-marine macroalgae (Undaria pinnatifida roots).

    Science.gov (United States)

    Jung, Kyung-Won; Kim, Kipal; Jeong, Tae-Un; Ahn, Kyu-Hong

    2016-01-01

    The collected roots of Undaria pinnatifida, the main waste in farming sites, accounting for 40-60% of annual production, was pyrolyzed under temperature ranging from 200 to 800°C to evaluate the influence of pyrolysis temperature on biochar properties and phosphate adsorption capacity. It was confirmed that an increase in the pyrolysis temperature led to a decrease of the yield of biochar, while ash content remained almost due to carbonization followed by mineralization. Elemental analysis results indicated an increase in aromaticity and decreased polarity at a high pyrolysis temperature. When the pyrolysis temperature was increased up to 400°C, the phosphate adsorption capacity was enhanced, while a further increase in the pyrolysis temperature lowered the adsorption capacity due to blocked pores in the biochar during pyrolysis. Finally, a pot experiment revealed that biochar derived from waste-marine macroalgae is a potent and eco-friendly alternative material for fertilizer after phosphate adsorption.

  16. Blade-order-dependent radiocarbon variability in brown seaweed (Undaria pinnatifida) reflected a cold Oyashio water intrusion event in an embayment of the Sanriku coast, northeastern Japan

    Science.gov (United States)

    Satoh, N.; Fukuda, H.; Miyairi, Y.; Yokoyama, Y.; Nagata, T.

    2015-12-01

    Radiocarbon in dissolved inorganic carbon (DIC) in seawater varies greatly, both geographically and with depth. This "reservoir effect" is thought to be reflected in the radiocarbon content (∆14C) of marine organisms, via DIC fixation by primary producers and subsequent trophic transfer. The ∆14C of marine organismal soft tissues might thus provide unique information about their habitats, diets, migration and other environmental histories. However, the effectiveness of this approach has yet to be extensively explored, with data on ∆14C variability in soft tissues of marine organisms being markedly limited. Here we examined whether ∆14C values of individual pinnate blades (leaf-like structures) of brown seaweed (Undaria pinnatifida) reflect the ∆14C of DIC in the water current prevailing at the time of blade formation. The study was conducted in Otsuchi Bay located in the Sanriku coastal region, northeastern Japan, where 14C-depleted cold Oyashio current and warm Tsugaru current (high ∆14C) converge, affecting the physiology and growth of marine organisms growing there. U. pinnatifida individuals cultured in the bay (length of saprophytes, 140-215 cm) were harvested in April 2014 and ∆14C of blades were determined by accelerator mass spectrometry. Younger blades formed after the Oyashio water intrusion had significantly lower ∆14C values compared to older blades formed before the event. The ∆14C values of younger and older blades were generally consistent with the ∆14C of DIC in Oyashio (-60.5 ‰) and Tsugaru (24.9 ‰) waters, respectively. Thus, despite possible turnover of organic carbon in seaweed soft tissues, blade-order-dependent ∆14C variability appeared to strongly reflect the Oyashio intrusion event (radiocarbon shift) in the bay.

  17. Biosynthesis of gold and silver chloride nanoparticles mediated by Crataegus pinnatifida fruit extract: in vitro study of anti-inflammatory activities.

    Science.gov (United States)

    Kang, Jong Pyo; Kim, Yeon Ju; Singh, Priyanka; Huo, Yue; Soshnikova, Veronika; Markus, Josua; Ahn, Sungeun; Chokkalingam, Mohan; Lee, Hyun A; Yang, Deok Chun

    2017-09-18

    This research article investigates the one-pot synthesis of gold and silver chloride nanoparticles functionalized by fruit extract of Crataegus pinnatifida as reducing and stabilizing agents and their possible roles as novel anti-inflammatory agents. Hawthorn (C. pinnatifida) fruits are increasingly popular as raw materials for functional foods and anti-inflammatory potential agents because of abundant flavonoids. The reduction of auric chloride and silver nitrate by the aqueous fruit extract led to the formation of gold and silver chloride nanoparticles. The nanoparticles were further characterized by field emission transmission electron microscopy indicated that CP-AuNps and CP-AgClNps were hexagonal and cubic shape, respectively. According to X-ray diffraction results, the average crystallite sizes of CP-AuNps and CP-AgClNps were 14.20 nm and 24.80 nm. The biosynthesized CP-AgClNps served as efficient antimicrobial agents against Escherichia coli and Staphylococcus aureus. Furthermore, CP-AuNps and CP-AgClNps enhanced the DPPH radical scavenging activity of the fruit extract. Lastly, MTT assay of nanoparticles demonstrated low toxicity in murine macrophage (RAW264.7). Biosynthesized nanoparticles also reduced the production of the inflammatory cytokines including nitric oxide and prostaglandin E2 in lipopolysaccharide-induced RAW264.7 cells. Altogether, these findings suggest that CP-AuNps and CP-AgClNps can be used as novel drug carriers or biosensors with intrinsic anti-inflammatory activity.

  18. Screening of the components with blood-anticoagulant activity from marine algae Sargassum fusiforme and Undaria pinnatifida%羊栖菜和裙带菜中抗凝血活性物质的初步筛选

    Institute of Scientific and Technical Information of China (English)

    刘承初; 周颖; 邬英睿; 甘建红; 周培根

    2004-01-01

    Components with blood-anticoagulant activity were fractionated from marine algae Sargassumfusiforrne and Undaria pinnatifida and the activity of the components was investigated by using the method of bioassay. It was found that the 80% ethanol soluble fraction of Sargassumfusiforme exhibited no blood-anticoagulant activity, while the components obtained from the 80 % ethanol insoluble fraction (hot water extract) gave obvious bloodanticoagulant activity. A further study suggests that the principal component in the hot water extract from Sargassumfusiforrne with high blood-anticoagulant activity should be sulfated polysaccharides, in which the activity was positively correlated with the content of total sugar and fucose in sulfated polysaccharides. As for Undaria pinnatifida, the n-butanol extract fractionated from the 80% ethanol soluble fraction had blood anticoagulant activity, while the petroleum ether, ether, ethyl acetate, or water extract showed no bloodanticoagulant activity.

  19. Hawthorn (Crataegus pinnatifida Bunge) leave flavonoids attenuate atherosclerosis development in apoE knock-out mice.

    Science.gov (United States)

    Dong, Pengzhi; Pan, Lanlan; Zhang, Xiting; Zhang, Wenwen; Wang, Xue; Jiang, Meixiu; Chen, Yuanli; Duan, Yajun; Wu, Honghua; Xu, Yantong; Zhang, Peng; Zhu, Yan

    2017-02-23

    Hawthorn (Crataegus pinnatifida Bunge) leave have been used to treat cardiovascular diseases in China and Europe. Hawthorn leave flavonoids (HLF) are the main part of extraction. Whether hawthorn leave flavonoids could attenuate the development of atherosclerosis and the possible mechanism remain unknown. High-fat diet (HFD) mixed with HLF at concentrations of 5mg/kg and 20mg/kg were administered to apolipoprotein E (apoE) knock out mice. 16 weeks later, mouse serum was collected to determine the lipid profile while the mouse aorta dissected was prepared to measure the lesion area. Hepatic mRNA of genes involved in lipid metabolism were determined. Peritoneal macrophages were collected to study the impact of HLF on cholesterol efflux, formation of foam cell and the expression of ATP binding cassette transporter A1 (ABCA1). Besides, in vivo reverse cholesterol transport (RCT) was conducted. HLF attenuated the development of atherosclerosis that the mean atherosclerotic lesion area in en face aortas was reduced by 23.1% (P<0.05). In mice fed with 20mg/kg HLF, Total cholesterol (TC) level was decreased by 18.6% and very low density lipoprotein cholesterol plus low density lipoprotein cholesterol (VLDLc+LDLc) level were decreased by 23.1% whereas high density lipoprotein cholesterol (HDLc) and triglyceride (TG) levels were similar compared to that of the control group. Peroxisome proliferator activated receptor alpha (PPARα) mRNA was increased by 31.2% (P<0.05) and 60.9% (P<0.05) in mice fed with 5mg/kg and 20mg/kg HLF respectively. Sterol regulatory element binding protein-1c (SREBP-1c) was decreased by 59.3% in the group of 20mg/kg. Carnitine palmitoyl transferase 1 (CPT-1) mRNA level of 20mg/kg group was induced 66.7% (P<0.05). Superoxide dismutase 1 and 2 (SOD1 and SOD2) mRNA were induced 25.4% (P<0.05) and 71.4% (P<0.05) while induced by 36.3% (P<0.05) and 73.2% (P<0.05) in group of 20mg/kg. Glutathione peroxidase 3 (Gpx3) mRNA in the group of 20mg/kg was induced

  20. Radioactive cesium accumulation in seaweeds by the Fukushima 1 Nuclear Power Plant accident-two years' monitoring at Iwaki and its vicinity.

    Science.gov (United States)

    Kawai, Hiroshi; Kitamura, Akira; Mimura, Mari; Mimura, Tetsuro; Tahara, Tomoya; Aida, Daiki; Sato, Kenji; Sasaki, Hideaki

    2014-01-01

    Accumulations of radionuclides in marine macroalgae (seaweeds) resulting from the Fukushima 1 Nuclear Power Plant (F1NPP) accident in March 2011 have been monitored for two years using high-purity germanium detectors. Algal specimens were collected seasonally by snorkeling at Nagasaki, Iwaki, Fukushima Prefecture (Pref.), Japan, ca. 50 km perimeter from the F1NPP. Additional collections were done at Soma, Hironocho, Hisanohama and Shioyazaki in Fukushima Pref. as well as at Chiba Pref. and Hyogo Pref. as controls. In May 2011, specimens of most macroalgal species showed ¹³⁷Cs levels greater than 3,000 Bq kg⁻¹ at Shioyazaki and Nagasaki. The highest ¹³⁷Cs level recorded 7371.20 ± 173.95 Bq kg⁻¹ in Undaria pinnatifida (Harvey) Suringar on 2 May 2011, whereas seawater collected at the same time at Shioyazaki and Nagasaki measured 8.41 ± 3.21 and 9.74 ± 3.43 Bq L⁻¹, respectively. The concentration factor of marine macroalgae was estimated to be ca. 8-50, depending on taxa and considering a weight ratio of wet/dry samples of ca. 10. ¹³⁷Cs level declined remarkably during the following 5-6 months. In contrast, the ¹³⁷Cs level remained rather stable during the following 12-16 months, and maintained the range of 10-110 Bq kg⁻¹. Contamination was still detectable in many samples in March 2013, 24 months after the most significant pollution.

  1. [Scientific revolution and embryology: rejection or transformation of antiquity? A comparison between the procreation teachings of Cesare Cremonini, William Harvey und René Descartes].

    Science.gov (United States)

    Lo Presti, Roberto

    2014-01-01

    In this paper I address the issue of the theoretical and epistemological status of embryology at the rise of the so-called "Scientific Revolution" (also in the first half of the seventeenth-century) and raise the question, in what sense and to what extent the historiographical concept of "Scientific Revolution" is applicable to the domain of embryology. To achieve this aim I compare the theories of three protagonists of the medical, scientific and philosophical debate of that age, namely Cesare Cremonini, William Harvey and René Descartes, who had very different views on the world structure and human nature and a very different concept of science, but who shared, as concerns embryological issues, an epigenetic conception of the development of the embryo. Their theories are discussed and compared in light of following questions: 1) What do Cremonini's, Harvey's and Descartes's embryological theories exactly aim to?; 2) In developing their theories, do these thinkers deal explicitly or implicitly with the Aristotelian and the Galenic embryological paradigm?; 3)Do they refer polemically to the Aristotelian and the Galenic tradition and what theoretical and/or rhetorical function have these polemical references?; 4) Do the embryological theories of Cremonini, Harvey and Descartes reflect the century-long dispute between "(Aristotelian) philosophers" and "(Galenic) doctors"?; 5) How is represented embryology as a 'scientific' and/or 'theoretical' domain? And what relationship between concepts of 'truth', 'research', 'tradition' and 'scientific progress' is implied or proposed in the embryological works of these three thinkers? What kind of use do Cremonini, Harvey and Descartes make of the argumenta ex ratione and of those ex experientia?

  2. Chronic fatigue syndrome: Harvey and Wessely's (biopsychosocial model versus a bio(psychosocial model based on inflammatory and oxidative and nitrosative stress pathways

    Directory of Open Access Journals (Sweden)

    Twisk Frank NM

    2010-06-01

    Full Text Available Abstract Background In a recently published paper, Harvey and Wessely put forward a 'biopsychosocial' explanatory model for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS, which is proposed to be applicable to (chronic fatigue even when apparent medical causes are present. Methods Here, we review the model proposed by Harvey and Wessely, which is the rationale for behaviourally oriented interventions, such as cognitive behaviour therapy (CBT and graded exercise therapy (GET, and compare this model with a biological model, in which inflammatory, immune, oxidative and nitrosative (IO&NS pathways are key elements. Discussion Although human and animal studies have established that the pathophysiology of ME/CFS includes IO&NS pathways, these abnormalities are not included in the model proposed by Harvey and Wessely. Activation of IO&NS pathways is known to induce fatigue and somatic (F&S symptoms and can be induced or maintained by viral and bacterial infections, physical and psychosocial stressors, or organic disorders such as (autoimmune disorders. Studies have shown that ME/CFS and major depression are both clinical manifestations of shared IO&NS pathways, and that both disorders can be discriminated by specific symptoms and unshared or differentiating pathways. Interventions with CBT/GET are potentially harmful for many patients with ME/CFS, since the underlying pathophysiological abnormalities may be intensified by physical stressors. Conclusions In contrast to Harvey and Wessely's (biopsychosocial model for ME/CFS a bio(psychosocial model based upon IO&NS abnormalities is likely more appropriate to this complex disorder. In clinical practice, we suggest physicians should also explore the IO&NS pathophysiology by applying laboratory tests that examine the pathways involved.

  3. WIKI应用案例评述——来自Harvey Mudd College和东京慈惠会医科大学的研究

    Institute of Scientific and Technical Information of China (English)

    郭桂英; 毛春华; 杨美清

    2008-01-01

    本文介绍了WIKI这种社会软件的概念、功能和作用,详细评述了Harvey Mudd College和东京慈惠会医科大学应用WIKI的实例,希望能够对我国研究者提供借鉴参考,来拓展WIKI的研究视野和应用领域.

  4. Practical burns management Practical burns management Harvey J Kemble B Lamb Hodder & Stoughton 262pp £9.95 0-340-36997-3.

    Science.gov (United States)

    1989-06-24

    J Harvey Kemble and Brenda Lamb aim to equip staff without a specialist knowledge in the care of burns patients with practical information so that they can give the correct care. The authors cover burns patients ranging from those requiring first aid in an A&E department to those needing admission to an intensive care unit. This seemed to be a very ambitious aim for any book, so I decided to test its claims.

  5. OS LIMITES DO ‘DESENVOLVIMENTO LOCAL’ E AS POSSIBILIDADES ABERTAS PELA ABORDAGEM DIALÉTICA PROPOSTA POR DAVID HARVEY PARA COMPREENDER UMA REGIÃO

    Directory of Open Access Journals (Sweden)

    Rogério Faé

    2012-12-01

    Full Text Available O objetivo deste artigo é fundamentar a escolha pela perspectiva teórica do materialismo histórico-geográfico, desenvolvida pelo geógrafo David Harvey para compreender uma região. Para tanto, apresentamos e discutimos também os referenciais predominantes nas análises sobre regiões, com o intuito de demonstrar os limites desses referenciais e as possibilidades abertas pela perspectiva de Harvey. Assim, apresentamos alguns dos principais conceitos que têm orientado as ações de governos dos mais diversos matizes; a abordagem de David Harvey bem como seus pressupostos teóricos e históricos; e uma análise comparativa em que demonstramos as limitações dos referenciais predominantes e as possibilidades da perspectiva do último autor. Ao final, conclui-se que o materialismo histórico-geográfico permite compreender que as dinâmicas sociais e econômicas de uma região se caracterizam em processos conflituosos e contraditórios e resultam em uma configuração regional específica e transitória.

  6. Multistep process of neoplastic transformation of normal human fibroblasts by 60Co gamma rays and Harvey sarcoma viruses

    Energy Technology Data Exchange (ETDEWEB)

    Namba, M.; Nishitani, K.; Fukushima, F.; Kimoto, T.; Nose, K.

    1986-03-15

    As reported previously (Namba et al., 1985), normal human fibroblasts were transformed by 60Co gamma-ray irradiation into immortal cells with abnormal karyotypes. These transformed cells (KMST-6), however, showed a low cloning efficiency in soft agar and no transplantability. However, upon treatment with Harvey murine sarcoma virus (Ha-MSV), the cells acquired elevated clonability in soft agar and transplantability in nude mice. Ha-MSV alone, however, did not convert normal human fibroblasts into either immortal or tumorigenic cells. The Ha-MSV-transformed KMST-6 cells showed an enhanced expression of the ras oncogene, but normal and 60Co gamma-ray-transformed cells did not. Our current data suggest that gamma rays worked against normal human cells as an initiator, giving rise to chromosome aberrations and immortality, and that Ha-MSV, probably through its ras oncogene, played a role in the progression of the malignant cell population to a more malignant one showing enhanced colony formation in soft agar and tumorigenicity in nude mice.

  7. Urban common space, heterotopia and the right to the city: Reflections on the ideas of Henri Lefebvre and David Harvey

    Directory of Open Access Journals (Sweden)

    Orlando Alves dos Santos Junior

    2014-05-01

    Full Text Available A city’s common spaces are appropriated by capital that aims to guarantee the conditions necessary for the production-reproduction of capitalist relations. In this context, the challenge is to imagine and construct a very different type of city capable of breaking away from the dynamic of capital, founded on new forms of appropriation of the city, which implies articulating both theory and praxis. For this to occur, however, it is necessary to create new knowledge about the city and a strong anti-capitalist social movement focused on the transformation of daily urban life and involving new forms of appropriation of urban common spaces. It is in this context, and from a dialectic perspective, that this article articulates the ideas of Henri Lefebvre and David Harvey, seeking to contribute to an understanding of the production processes of space in contemporary capitalism, the discussion of the future of cities and perspectives on transition. To do so, the article addresses four central ideas: (i the dialectic conception of space to problematize the production and appropriation of urban common spaces; (ii the recognition of urban common spaces as spaces traversed by contradictions, disputes and material and symbolic conflicts among different agents; (iii the right to the city as a need and as a utopian project; and (iv the challenge of articulating heterotopic practices from the perspective of creative rebellion for the right to the city and the transition to a new urban future.

  8. An Efficient Method for the Preparative Isolation and Purification of Flavonoids from Leaves of Crataegus pinnatifida by HSCCC and Pre-HPLC

    Directory of Open Access Journals (Sweden)

    Lei Wen

    2017-05-01

    Full Text Available In this work, flavonoid fraction from the leaves of Crataegus pinnatifida was separated into its seven main constituents using a combination of HSCCC coupled with pre-HPLC. In the first step, the total flavonoid extract was subjected to HSCCC with a two-solvent system of chloroform/methanol/water/n-butanol (4:3:2:1.5, v/v, yielding four pure compounds, namely (–-epicatechin (1, quercetin-3-O-(2,6-di-α-l-rhamnopyranosyl-β-d-galactopyranoside (2, 4′′-O-glucosylvitexin (3 and 2′′-O-rhamnosylvitexin (4 as well as a mixture of three further flavonoids. An extrusion mode was used to rapidly separate quercetin-3-O-(2,6-di-α-l-rhamnopyranosyl-β-d-galactopyranoside with a big KD-value. In the second step, the mixture that resulted from HSCCC was separated by pre-HPLC, resulting in three pure compounds including: vitexin (5, hyperoside (6 and isoquercitrin (7. The purities of the isolated compounds were established to be over 98%, as determined by HPLC. The structures of these seven flavonoids were elucidated by ESI-MS and NMR spectroscopic analyses.

  9. An Efficient Method for the Preparative Isolation and Purification of Flavonoids from Leaves of Crataegus pinnatifida by HSCCC and Pre-HPLC.

    Science.gov (United States)

    Wen, Lei; Lin, Yunliang; Lv, Ruimin; Yan, Huijiao; Yu, Jinqian; Zhao, Hengqiang; Wang, Xiao; Wang, Daijie

    2017-05-09

    In this work, flavonoid fraction from the leaves of Crataegus pinnatifida was separated into its seven main constituents using a combination of HSCCC coupled with pre-HPLC. In the first step, the total flavonoid extract was subjected to HSCCC with a two-solvent system of chloroform/methanol/water/n-butanol (4:3:2:1.5, v/v), yielding four pure compounds, namely (-)-epicatechin (1), quercetin-3-O-(2,6-di-α-l-rhamnopyranosyl)-β-d-galactopyranoside (2), 4''-O-glucosylvitexin (3) and 2''-O-rhamnosylvitexin (4) as well as a mixture of three further flavonoids. An extrusion mode was used to rapidly separate quercetin-3-O-(2,6-di-α-l-rhamnopyranosyl)-β-d-galactopyranoside with a big KD-value. In the second step, the mixture that resulted from HSCCC was separated by pre-HPLC, resulting in three pure compounds including: vitexin (5), hyperoside (6) and isoquercitrin (7). The purities of the isolated compounds were established to be over 98%, as determined by HPLC. The structures of these seven flavonoids were elucidated by ESI-MS and NMR spectroscopic analyses.

  10. 马克思和哈维的时空观比较研究%Comparative Study on View of Time-space between Marx and Harvey

    Institute of Scientific and Technical Information of China (English)

    庄穆; 周丹

    2015-01-01

    Marx extended the natural view of time-space to social field.On the basis of Marx’ s time space view, Harvey put forward the dialectical view of space-time with more emphasis on space perspective.The views of time-space on Marx and Harvey generated from different backgrounds and had different value orientations:Marx’ s view is based on the free all-round development of human beings, whereas Harvey’ s view on dialectical utopia.The view of time-space is closely linked to the development.It is hoped that through the comparative study of the concept of space-time in Marx and Harvey,a new perspective for the current development of Chinese society can be obtained.%马克思将自然时空延伸到社会领域,哈维在继承马克思时空观的基础上,提出了辩证的时空观,并且更加强调空间的维度。马克思和哈维的时空观产生在不同的时代背景下,具有不同的价值旨归,马克思的时空观是以人的自由而全面发展为价值指向的,而哈维则是以辩证的乌托邦为价值指向。时空观与社会发展紧密联系,对马克思和哈维的时空观比较,可为中国当前的社会发展提供一个新的发展视角。

  11. Harvey Cushing as a book collector, bibliophile, and archivist: the precedence for the genesis of the Brain Tumor Registry. Historical vignette.

    Science.gov (United States)

    Wahl, Christopher J; Tubbs, R Shane; Spencer, Dennis D; Cohen-Gadol, Aaron A

    2009-11-01

    Influenced by individuals such as his parents, Osler, and Halsted, and by his early medical student experience, Harvey Cushing developed a strong interest in collecting, especially antiquarian medical books. Even today, his collection housed at Yale University is one of the most prestigious in the world. Cushing's interest in archives is further manifested and reinforced by his establishment of the Cushing Brain Tumor Registry. The following is a review of Cushing's background not as an eminent clinician and surgeon but as an individual best described as a bibliophile, archivist, and ardent collector of medical paraphernalia.

  12. François Harvey, Alain Robbe-Grillet: le nouveau roman composite. Intergénéricité et intermédialité

    OpenAIRE

    2016-01-01

    Secondo Robbe-Grillet, cinema e letteratura sarebbero due attività indipendenti l’una dall’altra. F. Harvey, in questo volume, intende dimostrare esattamente il contrario: cioè come le opere robbe-grillettiane rispondano di un’ibridità dei generi, di una mescolanza, una combinazione tra diverse forme d’arte, dando vita a creazioni eterogenee e meticcie. Questo décloisonnement – termine che ritorna più volte nel ragionamento dell’A., a indicare una contaminazione dei registri e dei materiali u...

  13. Harvey Cushing and pituitary Case Number 3 (Mary D.): the origin of this most baffling problem in neurosurgery.

    Science.gov (United States)

    Pascual, José María; Prieto, Ruth

    2016-07-01

    From the very beginning of his career, Harvey Williams Cushing (1869-1939) harbored a deep interest in a complex group of neoplasms that usually developed at the infundibulum. These were initially known as "interpeduncular" or "suprasellar" cysts. Cushing introduced the term "craniopharyngioma" for these lesions, which he believed represented one of the most baffling problems faced by neurosurgeons. The patient who most influenced Cushing's thinking was a 16-year-old seamstress named "Mary D.," whom he attended in December 1901, exactly the same month that Alfred Fröhlich published his seminal article describing an adiposogenital syndrome in a young boy with a pituitary cyst. Both Cushing's and Fröhlich's patients showed similar symptoms caused by the same type of tumor. Notably, Cushing and Fröhlich had met one another and became good friends in Liverpool the summer before these events took place. Their fortunate relationship led Cushing to realize that Fröhlich's syndrome represented a state of hypopituitarism and provided a useful method of diagnosing interpeduncular cysts. It is noteworthy that Cushing's very first neurosurgical procedure on a pituitary tumor was performed in the case of Mary D.'s "interpeduncular cyst," on February 21, 1902. Cushing failed to remove this lesion, which was later found during the patient's autopsy. This case was documented as Pituitary Case Number 3 in Cushing's masterpiece, The Pituitary Body and Its Disorders, published in 1912. This tumor was considered "a teratoma"; however, multiple sources of evidence suggest that this lesion actually corresponded to an adamantinomatous craniopharyngioma. Unfortunately, the pathological specimens of this lesion were misplaced, and this prompted Cushing's decision to retain all specimens and documents of the cases he would operate on throughout his career. Accordingly, Mary D.'s case crystallized the genesis of the Cushing Brain Tumor Registry, one of Cushing's major legacies to

  14. 1,25-Dihydroxyvitamin D inhibits glutamine metabolism in Harvey-ras transformed MCF10A human breast epithelial cell.

    Science.gov (United States)

    Zhou, Xuanzhu; Zheng, Wei; Nagana Gowda, G A; Raftery, Daniel; Donkin, Shawn S; Bequette, Brian; Teegarden, Dorothy

    2016-10-01

    Breast cancer is the second most common cancer among women in the US. The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), is proposed to inhibit cellular processes and to prevent breast cancer. The current studies investigated the effect of 1,25(OH)2D on glutamine metabolism during cancer progression employing Harvey-ras oncogene transformed MCF10A human breast epithelial cells (MCF10A-ras). Treatment with 1,25(OH)2D significantly reduced intracellular glutamine and glutamate levels measured by nuclear magnetic resonance (NMR) by 23±2% each. Further, 1,25(OH)2D treatment reduced glutamine and glutamate flux, determined by [U-(13)C5] glutamine tracer kinetics, into the TCA cycle by 31±0.2% and 17±0.4%, respectively. The relative levels of mRNA and protein abundance of the major glutamine transporter, solute linked carrier family 1 member A5 (SLC1A5), was significantly decreased by 1,25(OH)2D treatment in both MCF10A-ras cells and MCF10A which overexpress ErbB2 (HER-2/neu). Consistent with these results, glutamine uptake was reduced by 1,25(OH)2D treatment and the impact was eliminated with the SLC1A5 inhibitor L-γ-Glutamyl-p-nitroanilide (GPNA). A consensus sequence to the vitamin D responsive element (VDRE) was identified in silico in the SLC1A5 gene promoter, and site-directed mutagenesis analyses with reporter gene studies demonstrate a functional negative VDRE in the promoter of the SLC1A5 gene. siRNA-SLC1A5 transfection in MCF10A-ras cells significantly reduced SLC1A5 mRNA expression as well as decreased viable cell number similar to 1,25(OH)2D treatment. SLC1A5 knockdown also induced an increase in apoptotic cells in MCF10A-ras cells. These results suggest 1,25(OH)2D alters glutamine metabolism in MCF10A-ras cells by inhibiting glutamine uptake and utilization, in part through down-regulation of SLC1A5 transcript abundance. Thus, 1,25(OH)2D down-regulation of the glutamine transporter, SLC1A5, may facilitate vitamin D prevention of breast

  15. Comparation of Hypolipidemic and Antioxidant Effects of Aqueous and Ethanol Extracts of Crataegus pinnatifida Fruit in High-Fat Emulsion-Induced Hyperlipidemia Rats.

    Science.gov (United States)

    Shao, Feng; Gu, Lifei; Chen, Huijuan; Liu, Ronghua; Huang, Huilian; Ren, Gang

    2016-01-01

    Hawthorn (Crataegus pinnatifida) is a Chinese medicinal plant traditionally used in the treatment of hyperlipidemia. Recently, studies indicated free radical scavenging was one of the major pathways to alleviate hyperlipidemia. Moreover, hawthorn fruit is a rich source of phenols, which quench free radical and attenuate hyperlipidemia. However, the phenols vary with processing methods, especially solvent type. Our aim was to compare hypolipidemic and antioxidant effects of aqueous and ethanol extracts of hawthorn fruit in hyperlipidemia rats. After a 4-week treatment of high-fat emulsion, lipid profile levels and antioxidant levels of two extracts were determined using commercial analysis. Total phenols content in the extract of hawthorn fruit was determined colorimetrically by the Folin-Ciocalteu method. Both ethanol and aqueous extracts of hawthorn fruit possessed hypolipidemic and antioxidant activities. Simultaneously, stronger activities were observed in ethanol extract. Besides, total phenols content in ethanol extract from the same quality of hawthorn fruit was 3.9 times more than that in aqueous extract. The obvious difference of hypolipidemic and antioxidant effects between ethanol extract and aqueous extract of hawthorn fruit was probably due to the presence of total phenols content, under the influence of extraction solvent. Ethanol extract of hawthorn fruit exhibited more favorable hypolipidemic and antioxidant effects than aqueous extract. The higher effects could be due to the higher content of total phenols that varies with extraction solvent. Abbreviations used: TC: Total cholesterol, TG: Triglyceride, LDL-C: Low-density lipoprotein cholesterol, HDL-C: High-density lipoprotein cholesterol, GSH-Px: Glutathione peroxidase, SOD: Superoxide dismutase, MDA: Malondialdehyde, CAT: Catalase, NO: Nitric oxide, NOS: Nitric oxide synthase, SR-BI: Scavenger receptor Class B Type I.

  16. An antithrombotic fucoidan, unlike heparin, does not prolong bleeding time in a murine arterial thrombosis model: a comparative study of Undaria pinnatifida sporophylls and Fucus vesiculosus.

    Science.gov (United States)

    Min, Soon-Ki; Kwon, Oh-Choon; Lee, Sub; Park, Ki-Hyuk; Kim, Jong-Ki

    2012-05-01

    The antithrombotic activities and bleeding effects of selected fucoidans (source from either Undaria pinnatifida sporophylls or from Fucus vesiculosus) have been compared with heparin in the ferric chloride-induced arterial thrombus mouse model. Thrombosis was induced by applying 5% ferric chloride for 3 min on the carotid artery region of Balb/c mouse. Five minutes prior to thrombus induction, mice were infused through the tail vein with either saline (control) or polysaccharides. Either fucoidan or heparin was dosed at 0.1, 1.25, 2.5, 5.0, 10, 25, or 50 mg/kg intravenously (i.v.) The carotid blood flow was monitored until more than 60 min post-thrombus induction. Mouse tail transection bleeding time was measured up to 60 min after making a cut in the mouse tail. Both antithrombotic and bleeding effects were observed in a dose-dependent manner for both fucoidans and heparin. Thrombus formation was totally (reflected by Doppler flow meter) inhibited at either 5 or 50 mg/kg of unfractionated Undaria fucoidan or a low-molecular-weight Undaria fucoidan fraction, respectively, without prolonging the time-to-stop bleeding compared with the control (p Fucus fucoidan at 25 mg/kg where the time-to-stop bleeding was still significantly prolonged, by as much as 8 ± 1.7 min (p < 0.02). In contrast the heparin-treated group showed total inhibition of thrombus formation even at a small dose of 0.8 mg/kg (400 IU) at which bleeding continued until 60 min. In conclusion algal fucoidans are highly antithrombotic without potential haemorrhagic effects compared with heparin in the arterial thrombus model, but this property differs from algal species to species, and from the molecular structure of fucoidans.

  17. La justicia social y la Utopía dialética: Discutiendo con Harvey sobre espacio público

    Directory of Open Access Journals (Sweden)

    Márcio Valença

    2013-06-01

    Full Text Available Este ensayo explora la idea de justicia social y, teniendo en cuenta el papel del espacio público, el pensamiento utópico de David Harvey sobre el futuro de las ciudades. Este conocido geógrafo Inglés, que vive en EE.UU., dedica su vida a construir una teoría del desarrollo geográfico desigual que objetiva elaborar propuestas alternativas que empiecen un proceso continuo de cambios progresistas en la búsqueda de una sociedad más justa. El artículo analiza varios de sus escritos y construcciones teóricas, incluyendo a las que se refieren a la “justicia distributiva territorial” y el “utopianismo dialéctico”, como también las versiones modificadas del “derecho a la ciudad”, de Henri Lefebvre, y de “cosmopolitismo subalterno”, de Boaventura de Souza Santos. Harvey piensa que es fundamental que toda la infraestructura física y el aparato institucional producidos por la sociedad burguesa en los últimos 500 años sean sustituidos por otros sistemas que den origen a un espacio y lugar relacional alternativo, construido a partir de una “reflexión filosófica”, una “evaluación de requerimientos prácticos y de necesidades humanas básicas” y del “fermento de los movimientos sociales”.

  18. Study on William Harvey's Scientific Research Ethical Thought%威廉·哈维的科研伦理思想研究

    Institute of Scientific and Technical Information of China (English)

    刘月树; 陆于宏; 唐健

    2012-01-01

    WiHiam Harvey's scientific research ethical thought was his motivation and guideline on his research. The key contents of his thoughts are concluding; pursuing the truth, the critical thinking, objective and impartial, seeking truth from facts, ami respecting the peers and so forth. Harvey's thinking on research ethics not only had the theoretical significance, but also established a moral model for the following scientists. Although his thought and practice had a certain limitations, it contains high quality which still is the moral guide for contemporary scientists.%威廉·哈维的科研伦理思想是他进行科学研究的动力和指南.他的科研伦理思想主要表现在追求真理、勇于怀疑、客观公正、实事求是、友爱同道等几个方面.哈维的科研伦理思想对于后世的意义不仅仅是理论上的,更主要的是哈维通过自身的努力和实践,为后世树立了道德典范.虽然他的思想和实践具有一定的时代局限性,但其所包含的优良品质依然可以成为当代科学家的道德指南.

  19. Book Review: Maxwell's Demon 2: Entropy, classical and quantum information, computing. Harvey Leff and Andrew Rex (Eds.); Institute of Physics, Bristol, 2003, 500pp., US 55, ISBN 0750307595

    Science.gov (United States)

    Shenker, Orly R.

    2004-09-01

    In 1867, James Clerk Maxwell proposed a perpetuum mobile of the second kind, that is, a counter example for the Second Law of thermodynamics, which came to be known as "Maxwell's Demon." Unlike any other perpetual motion machine, this one escaped attempts by the best scientists and philosophers to show that the Second Law or its statistical mechanical counterparts are universal after all. "Maxwell's demon lives on. After more than 130 years of uncertain life and at least two pronouncements of death, this fanciful character seems more vibrant than ever." These words of Harvey Leff and Andrew Rex (1990), which open their introduction to Maxwell's Demon 2: Entropy, Classical and Quantum Information, Computing (hereafter MD2) are very true: the Demon is as challenging and as intriguing as ever, and forces us to think and rethink about the foundations of thermodynamics and of statistical mechanics.

  20. Vascular access: an historical perspective from Sir William Harvey to the 1956 Nobel prize to André F. Cournand, Werner Forssmann, and Dickinson W. Richards.

    Science.gov (United States)

    Sette, Piersandro; Dorizzi, Romolo M; Azzini, Anna M

    2012-01-01

    Sir William Harvey (1578-1657), who had many precursors, discovered blood circulation in 1628 after a significant number of anatomic dissection of cadavers; his studies were continued by Sir Christopher Wren and Daniel Johann Major. The first central vein catheterization was performed on a horse by Stephen Hales, an English Vicar. In 1844, a century later, the French biologist Claude Bernard attempted the first carotid artery cannulation and repeated the procedure in the jugular vein, again on a horse. He was first to report the complications now well known to be associated with this maneuver. In 1929 Werner Forssmann tried cardiac catheterization on himself, but could not investigate the procedure further since his findings were rejected and ridiculed by colleagues. His work was continued by André Frédéric Cournand and Dickinson Woodruff Richards Jr in the United States. In 1956 the three physicians shared the Nobel Prize for Medicine for their studies on vascular and cardiac systems. The genius and the perseverance of the three physicians paved the way towards peripheral and central catheter vein placement, one of the most frequently performed maneuvers in hospitals. Its history still remains unknown to most and deserves a short description.

  1. 粗江蓠多糖的提取及光谱分析%Extraction and Analysis of Gracilaria Gigas Harvey Polysaccharides

    Institute of Scientific and Technical Information of China (English)

    孟庆勇; 王亚飞; 揭新明; 东野广智; 张立坚

    2006-01-01

    采用热水浸提和乙醇沉淀的方法提取粗江蓠多糖(gracilaria gigas harvey polysacchrides,GHPS),用苯酚-硫酸法测定糖含量,等离子体原子发射光谱(ICP)测多糖中矿物元素的含量,傅里叶红外光谱仪(FTIR)分析糖类官能团.结果表明:采用热水浸提和乙醇沉淀的方法提取粗江蓠多糖提取率达14.98%,苯酚-硫酸法测得提取物多糖含量为78.2%;ICP测得粗江蓠多糖含Ca,Fe,Mg和S等矿物元素;FTIR分析GHPS有一般糖类物质的特征吸收峰,是一种酸性多糖,同时存在呋喃环和吡喃环.

  2. Três pontos de vista sobre o capitalismo atual: um estudo a partir de Harvey, Jameson, Zizek, Deleuze e Negri

    Directory of Open Access Journals (Sweden)

    Pedro Sobrino Laureano

    2014-04-01

    Full Text Available Procuramos apresentar e relacionar três visões distintas sobre o capitalismo. A primeira, compartilhada por Deleuze, Guattari, Negri e Hardt, aposta na radicalização da diferença contra os mecanismos modulatórios do mercado mundial. A segunda, presente nas teorias de Jameson e Harvey, critica o repudio pós-moderno às categorias universalistas, caracterizando o culto contemporâneo ao hibridismo e à pluralidade como reforço ideológico do novo capitalismo flexível surgido nos anos 70. Finalmente, no pensamento de Zizek, a crítica à ideologia da subjetividade múltipla é articulada à denegação capitalista da dimensão negativa, ou traumática, do sujeito. Buscamos sustentar por que as análises de Deleuze, Guattari, Negri e Hardt nos parecem mais pertinentes, ao procurarem positivar os elementos de constituição e resistência já presentes na atual conjuntura.

  3. "Fulfilling the chief of his duties as a physician": Harvey Cushing, selective dorsal rhizotomy and elective spine surgery for quality of life.

    Science.gov (United States)

    Dasenbrock, Hormuzdiyar H; Pendleton, Courtney; McGirt, Matthew J; Sciubba, Daniel M; Gokaslan, Ziya L; Quiñones-Hinojosa, Alfredo; Bydon, Ali

    2011-03-01

    At the beginning of the 20th century, the development of safer anesthesia, antiseptic techniques, and meticulous surgical dissection led to a substantial decrease in operative risk. In turn, the scope of surgery expanded to include elective procedures performed with the intention of improving the quality of life of patients. Between 1908 and 1912, Harvey Cushing performed 3 dorsal rhizotomies to improve the quality of life of 3 patients with debilitating neuralgia: a 54-year-old man with "lightning" radicular pain from tabes dorsalis, a 12-year-old boy cutaneous hyperesthesia and spasticity in his hemiplegic arm, and a 61-year-old man with postamputation neuropathic pain. Symptomatic improvement was seen postoperatively in the first 2 cases, although the third patient continued to have severe pain. Cushing also removed a prominent spinous process from each of 2 patients with debilitating headaches; both patients, however, experienced only minimal postoperative improvement. These cases, which have not been previously published, highlight Cushing's views on the role of surgery and illustrate the broader movement that occurred in surgery at the time, whereby elective procedures for quality of life became performed and accepted.

  4. “Fulfilling the chief of his duties as a physician”: Harvey Cushing, selective dorsal rhizotomy and elective spine surgery for quality of life

    Science.gov (United States)

    Dasenbrock, Hormuzdiyar H.; Pendleton, Courtney; McGirt, Matthew J.; Sciubba, Daniel M.; Gokaslan, Ziya L.; Quiñones-Hinojosa, Alfredo; Bydon, Ali

    2015-01-01

    At the beginning of the 20th century, the development of safer anesthesia, antiseptic techniques, and meticulous surgical dissection led to a substantial decrease in operative risk. In turn, the scope of surgery expanded to include elective procedures performed with the intention of improving the quality of life of patients. Between 1908 and 1912, Harvey Cushing performed 3 dorsal rhizotomies to improve the quality of life of 3 patients with debilitating neuralgia: a 54-year-old man with “lightning” radicular pain from tabes dorsalis, a 12-year-old boy cutaneous hyperesthesia and spasticity in his hemiplegic arm, and a 61-year-old man with postamputation neuropathic pain. Symptomatic improvement was seen postoperatively in the first 2 cases, although the third patient continued to have severe pain. Cushing also removed a prominent spinous process from each of 2 patients with debilitating headaches; both patients, however, experienced only minimal postoperative improvement. These cases, which have not been previously published, highlight Cushing's views on the role of surgery and illustrate the broader movement that occurred in surgery at the time, whereby elective procedures for quality of life became performed and accepted. PMID:21250816

  5. The autopsy was conducted "Under most inauspicious circumstances:" John Turner, Harvey Cushing's case XXXII, and his unwitting contributions to the early understanding of acromegaly.

    Science.gov (United States)

    Pendleton, Courtney; Wand, Gary; Quinones-Hinojosa, Alfredo

    2010-12-01

    Harvey Cushing's monograph The Pituitary Body and Its Disorders describes Case XXXII, a 36-year-old man who presented with gigantism in 1910. The detailed post-mortem exam findings are prefaced with a cryptic statement, describing "inauspicious circumstances" surrounding the autopsy. Although contemporary biographies of Cushing have offered insight into these circumstances, the original surgical file for Case XXXII has not been previously reviewed. The original Johns Hopkins Hospital surgical records were reviewed, and the case of John Turner, who Cushing identified by name in his monograph The Pituitary Body and Its Disorders, was selected for further review. A review of the original surgical file revealed a typewritten note by Dr. Crowe, one of the surgeons who performed the post-mortem exam, with a handwritten addendum by Dr. Cushing. This document provides detail regarding the "inauspicious circumstances" surrounding the autopsy. Namely, the autopsy was conducted without permission of the family, during the funeral service, following a payment to the undertaker. The new information regarding the autopsy of John Turner offers insight into the previously incompletely described circumstances surrounding the autopsy. Additionally, the case illuminates the obligations and ethical quandaries that physician-scientists face.

  6. Analyzing the Turns of David Harvey's Scholarship:A Case Study on the Innovation of Geographical Thought%地理学思想变革的案例剖析:哈维的学术转型

    Institute of Scientific and Technical Information of China (English)

    叶超; 蔡运龙

    2012-01-01

    David Harvey transformed from a positivist to a radicalist, and to a Marxist in the end. The turns of his scholarship are an important phenomenon in the western geography, and a typical case of innovation in geographical thought and epistemology. According to analyzing some representative works of Harvey, this paper focuses on epistemological problems, particularly the transformation of Harvey's view on space because of 'space as a keyword' in geography in accordance with Harvey himself. It is argued that his scholarship career mainly at least experienced three stages:the view of the relative but multidimensional space, the view of uniting'social- process-spatial-form' and the view of historical-geographical materialism spatial system. The three stages are corresponding with Harvey's scholarship career as a positivist, a radicalist, and finally a Marxist. On the basis of the statements of Harvey himself, this article sums up that there are some reasons why he fulfilled the shifts, I.e. The drastically changing social and political conditions, his individual interests and gifts, his working circumstances, the need for geography at that time, the other occasional factors. Harvey's academic transformation implies significance and inspiring for Chinese geographers. The geographers of China should treat correctly logical positivism geography, be confronted with key social practical problems and inquire into the deep reasons and build theories. Based on the principles of 'independent spirit, free thinking', Chinese geographers can contribute more to academy and society.%大卫·哈维的学术转型是当代西方地理学发展的一个重要现象,也是地理学思想创新的一个典型案例.本文聚焦于哈维空间观的转型,通过解析哈维学术转型的代表论著,认为哈维关于空间的认识论立场主要经历了以实证主义相对空间观为主的“多维”空间观、“社会过程一空间形式”统一体、历史一地理唯物主

  7. 正交试验法优选山楂袋泡茶的水提取工艺%Optimization of Water Extraction Technology for Total Flavonoids from Crataegus pinnatifida

    Institute of Scientific and Technical Information of China (English)

    殷钢; 吴健

    2013-01-01

    Objective: To optimize water extraction technology of total flavones from Crataegus pinnatifida. Method: Taking yield of total flavonoids as index, the content of total flavonoids was determined by UV, orthogonal test method was used to optimize ultrasonic extraction technology of total flavonoids with extraction time, ratio of solid-liquid, extraction temperature and powder size as factors. Result: Influence sequence of 4 factors on soaking technology was: extraction temperature > powder size > extraction time > ratio of solid-liquid, optimum extraction technology was as following: extraction temperature 95 ℃ , ratio of solid-liquid 1 : 300, extraction time 10 min, gringing degree 60 mesh, average yield of total flavonoids could be up to 9. 36 g · L-1 Conclusion: Optimized water extraction condition was stable and feasible, it could be used for taking of C. pinnatifida teabag.%目的:优选山楂袋泡茶的浸泡工艺.方法:以山楂总黄酮质量浓度为指标,采用紫外分光光度法测定山楂总黄酮含量,通过正交试验考察液料比、浸提时间、浸提温度和粉碎度对山楂袋泡茶浸泡工艺的影响.结果:各因素对浸泡工艺的影响顺序为浸提温度>山楂粉碎度>浸提时间>液料比.最佳浸泡工艺为液料比300 mL·g-l,浸提温度95℃,浸提时间10min,粉碎度60目,总黄酮得率达9.36 g·L-1.结论:优选的浸泡工艺稳定可行,可用于山楂袋泡茶的服用.

  8. Pensar la formación para la ciudadanía en clave espacial. Una lectura comprensiva de David Harvey y Doreen Massey

    Directory of Open Access Journals (Sweden)

    David Andrés Vidal López

    2015-10-01

    Full Text Available El presente artículo tiene como propósito inicial realizar una reflexión acerca de las potencialidades analíticas y conceptuales de la teoría espacial de Doreen Massey y David Harvey, en el análisis de la formación para la ciudadanía y la construcción de subjetividades desde la escuela. Para ello, se revisan los conceptos de espacio y espacialidad que los autores han propuesto en dos de sus trabajos más representativos: La condición de la posmodernidad (Harvey, 2003 y Ciudad mundial (Massey, 2008. Se comentan, a modo de introducción y antecedentes, algunas de las propuestas conceptuales del filósofo francés Henri Lefebvre, quien ha realizado un interesante acercamiento fenomenológico al concepto de espacio, sus representaciones y las experiencias vividas por los sujetos. Esta propuesta, de una u otra forma, se puede rastrear en autores como Milton Santos o Edward Soja. De este modo, se toma como punto de partida una premisa que sirve a la vez de eje articulador y de idea central del presente artículo: es relevante para el análisis socioespacial el uso social del territorio, y no el territorio per se. Esta idea está presente tanto en Milton Santos, como en Henri Lefebvre, Edward Soja y en los autores de los que nos ocupamos.En seguida, se exponen de manera muy sucinta algunas observaciones y registros tomados de la práctica pedagógica del autor del artículo con estudiantes de diversos grados del Centro Educativo Rural Olarte de la localidad de Usme en Bogotá. Estos registros hacen parte de las representaciones y concepciones sobre el espacio vivido por parte de los estudiantes. La información que se presenta no pretende seguir un método particular de análisis, sino que se vincula en la reflexión para ilustrar la aplicación de los conceptos de los dos autores estudiados en escenarios escolares. De este modo, se podrán abordar los dos contextos conceptuales, escuela-espacio, y así comprender las

  9. 1α, 25-Dihydroxyvitamin D regulates hypoxia-inducible factor-1α in untransformed and Harvey-ras transfected breast epithelial cells.

    Science.gov (United States)

    Jiang, Yan; Zheng, Wei; Teegarden, Dorothy

    2010-12-01

    The purpose of this study was to determine the mechanism by which 1α, 25-dihydroxyvitamin D (1,25(OH)(2)D) alters hypoxia-inducible factor-1α (HIF-1α) protein in untransformed and Harvey-ras (H-ras) oncogene transfected MCF10A breast epithelial cells. Treatment with 1,25(OH)(2)D (10nM) increased both mRNA (2.55±0.6-fold vs. vehicle, p=0.03) and protein levels (2.37±0.3-fold vs. vehicle, pMCF10A cells in 12h, which remained elevated at 24h. However, in H-ras transfected MCF10A cells, 1,25(OH)(2)D treatment increased HIF-1α protein level (2.08±0.38-fold vs. vehicle, p=0.05) at 12h, with no change in mRNA level and HIF-1α protein level returned to baseline after 24h. A transcription inhibitor prevented the 1,25(OH)(2)D induction of HIF-1α protein and mRNA levels in MCF10A cells, but failed to alter the induction of HIF-1α protein level in H-ras transfected MCF10A cells. On the other hand, inhibition of proteasomal degradation prevented the 1,25(OH)(2)D-induced HIF-1α protein level in H-ras transfected MCF10A but not in MCF10A cells. These results support that 1,25(OH)(2)D regulates HIF-1α protein level via transcriptional regulation in MCF10A cells in contrast to through proteosomal degradation with the presence of H-ras oncogene in MCF10A cells.

  10. The role of Harvey Cushing and Walter Dandy in the evolution of modern neurosurgery in the Netherlands, illustrated by their correspondence.

    Science.gov (United States)

    Groen, Rob J M; Koehler, Peter J; Kloet, Alfred

    2013-03-01

    The development of modern neurosurgery in the Netherlands, which took place in the 1920s, was highly influenced by the personal involvement of both Harvey Cushing and Walter Dandy, each in his own way. For the present article, the authors consulted the correspondence (kept at the Cushing/Whitney Medical Library in New Haven and the Alan Mason Chesney Medical Archives in Baltimore) of Cushing and Dandy with their Dutch disciples. The correspondence provides a unique inside view into the minds of both neurosurgical giants. After the neurologist Bernard Brouwer had paved the way for sending the Dutch surgeon Ignaz Oljenick overseas, Cushing personally took the responsibility to train him (1927-1929). On his return to Amsterdam, Oljenick and Brouwer established the first neurosurgical department in the country. Encouraged by Oljenick's favorable results, a number of Dutch general surgeons started asking Cushing for support. Cushing strategically managed and deflected these requests, probably aiming to increase the advantage of Oljenick and Brouwer. However, the University Hospital in Groningen persisted in the plans to establish its own neurosurgical unit and sent Ferdinand Verbeek to the US in 1932. Although staying at Cushing's department initially, Verbeek ultimately applied to Walter Dandy for a position of visiting voluntary assistant, staying until the end of 1934. Verbeek and Dandy became lifelong friends. On his return to Groningen, Verbeek started practicing neurosurgery, isolated in the northern part of the country. He relied on the support of Dandy, with whom he kept up a regular correspondence, discussing cases and seeking advice. Dandy, on his part, used Verbeek as the ambassador in Europe for his operative innovations. At the beginning of World War II, Oljenick had to flee the country, which concluded the direct line with the Cushing school in the Netherlands. After Dandy's death (1946), Verbeek continued practicing neurosurgery following his style and

  11. Application of alkyl polyglycoside surfactant in ultrasonic-assisted extraction followed by macroporous resin enrichment for the separation of vitexin-2″-O-rhamnoside and vitexin from Crataegus pinnatifida leaves.

    Science.gov (United States)

    Han, Feng; Guo, Yupin; Gu, Huiyan; Li, Fenglan; Hu, Baozhong; Yang, Lei

    2016-02-15

    An alkyl polyglycoside (APG) surfactant was used in ultrasonic-assisted extraction to effectively extract vitexin-2″-O-rhamnoside (VOR) and vitexin (VIT) from Crataegus pinnatifida leaves. APG0810 was selected as the surfactant. The extraction process was optimized for ultrasonic power, the APG concentration, ultrasonic time, soaking time, and liquid-solid ratio. The proposed approach showed good recovery (99.80-102.50% for VOR and 98.83-103.19% for VIT) and reproducibility (relative standard deviation, n=5; 3.7% for VOR and 4.2% for VIT) for both components. The proposed sample preparation method is both simple and effective. The use of APG for extraction of key herbal ingredients shows great potential. Ten widely used commercial macroporous resins were evaluated in a screening study to identify a suitable resin for the separation and purification of VOR and VIT. After comparing static and dynamic adsorption and desorption processes, HPD100B was selected as the most suitable resin. After column adsorption and desorption on this resin, the target compounds VOR and VIT can be effectively separated from the APG0810 extraction solution. Recoveries of VOR and VIT were 89.27%±0.42% and 85.29%±0.36%, respectively. The purity of VOR increased from 35.0% to 58.3% and the purity of VIT increased from 12.5% to 19.9%. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. A Herbal Formula HT048, Citrus unshiu and Crataegus pinnatifida, Prevents Obesity by Inhibiting Adipogenesis and Lipogenesis in 3T3-L1 Preadipocytes and HFD-Induced Obese Rats.

    Science.gov (United States)

    Lee, Yoon Hee; Kim, Young-Sik; Song, Mikyung; Lee, Minsu; Park, Juyeon; Kim, Hocheol

    2015-05-26

    HT048 is a combination composed of Crataegus pinnatifida leaf and Citrus unshiu peel extracts. This study aimed to investigate potential anti-obesity effect of the combination. The 3T3-L1 adipocytes were treated with different doses of HT048 and triglyceride accumulation, glycerol release and adipogenesis-related genes were analyzed. For in vivo study, male Sprague Dawley rats were divided according to experimental diets: the chow diet group, the high-fat diet (HFD) group, the HFD supplemented with orlistat group, the HFD supplemented with HT048 group (0.2% or 0.4%) for 12 weeks. We measured the body weight, serum lipid levels and the expression of genes involved lipid metabolism. HT048 treatment dose-dependently suppressed adipocyte differentiation and stimulated glycerol release. The expressions of PPARγ and C/EBPα mRNA were decreased by HT048 treatment in adipocytes. HT048 supplementation significantly reduced the body and fat weights in vivo. Serum lipid levels were significantly lower in the HT048 supplemented groups than those of the HFD group. Expression of the hepatic lipogenesis-related genes were decreased and expression of the β-oxidation-related genes were increased in rats fed HT048 compared to that of animals fed HFD. These results suggest that HT048 has a potential benefit in preventing obesity through the inhibition of lipogenesis and adipogenesis.

  13. A diet formula of Puerariae radix, Lycium barbarum, Crataegus pinnatifida, and Polygonati rhizoma alleviates insulin resistance and hepatic steatosis in CD-1 mice and HepG2 cells.

    Science.gov (United States)

    Liu, Jia; Zhang, HongJuan; Ji, BaoPing; Cai, ShengBao; Wang, RuoJun; Zhou, Feng; Yang, JunSi; Liu, HuiJun

    2014-05-01

    According to the principles of traditional Chinese medicine, medicinal and edible herbs exhibit holistic effects through their actions on multiple target organs. Four herbs, Puerariae radix, Lycium barbarum, Crataegus pinnatifida, and Polygonati rhizoma, were selected and combined to create a new herbal formula (PLCP). The protective effects of both the aqueous extract (AE) and ethanol extract (EE) of PLCP against insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD) were evaluated in both high fat and high fructose diet-fed mice. Active fractions and constituents were screened in HepG2 cells with IR or an over-accumulation of triglycerides, and were further identified by high-performance liquid chromatography/electrospray ionization/mass spectrometry. The results indicate that the AE did not improve (p > 0.05) glucose tolerance after three weeks, whereas EE showed a promising effect throughout the experiment. Medium and high doses of EE were found to reduce fasting blood glucose at week 9 by 21.1% and 24.4%, respectively. In addition, their efficacies for alleviating IR were comparable with that of metformin. Compared with AE, EE effectively improved hyperlipidemia, antioxidant status, and NAFLD. In contrast, metformin did not alleviate hyperlipidemia (p > 0.05) or NAFLD in the mice model. Results from the cell-based study indicate that the protective effects of EE were possibly due to the actions from puerarin, 3'-methoxypuerarin, daidzin, daidzein, and ononin.

  14. 超声波法提取裙带菜中褐藻多糖硫酸酯的工艺研究%Extraction of Fucose-containing Sulfated Polysaccharides (FSP) from Undaria pinnatifida by Supersonic Method

    Institute of Scientific and Technical Information of China (English)

    谭洁怡; 王一飞; 钱垂文

    2006-01-01

    利用超声波法从裙带菜(Undaria pinnatifida)中提取褐藻多糖硫酸酯(FSP),以多糖提取率为指标,通过单因素和正交优化实验确立了提取FSP的最佳工艺条件,并与传统热水提取法进行了比较.结果表明,100倍加水量、在1 000 W功率下超声处理20 min能得到最大的多糖提取率.采用优化工艺,FSP得率(16.87%)、纯度(74.19%)和硫酸基含量(10.22%)比传统水提法分别提高了23.59%、30.92%和13.94%,色素和蛋白等杂质的析出减少,是一种良好的提取多糖方法.

  15. 降解裙带菜多糖对纳米硒的形成与稳定作用%Formation and Stabilization of Selenium Nano-particles in Aqueous Solution of Undaria Pinnatifida Charv. Suringer Polysaccharide

    Institute of Scientific and Technical Information of China (English)

    郑文杰; 黄亮; 杨芳; 白燕

    2007-01-01

    在常温下的降解裙带菜多糖(Degraded Undaria Pinnatifida Charv. Suringer polysaccharide, DUP)水溶液中, 由适当过量的抗坏血酸(Vc)与二氧化硒(SeO2)反应制备纳米单质硒(Se0). 通过共振瑞利散射、激光散射和透射电镜(TEM)研究了DUP对Se0粒径的调控和在液相中的稳定作用. 结果表明, DUP通过控制还原速度和表面修饰而把Se0粒子调节在较窄的粒径分布范围内当Se0浓度为0.0507~3.245 mmol/L时, DUP表面修饰的球状纳米硒的平均粒径稳定地保持在24~65 nm范围内, 4 ℃时可在水溶液中稳定保存1个月.

  16. A Herbal Formula HT048, Citrus unshiu and Crataegus pinnatifida, Prevents Obesity by Inhibiting Adipogenesis and Lipogenesis in 3T3-L1 Preadipocytes and HFD-Induced Obese Rats

    Directory of Open Access Journals (Sweden)

    Yoon Hee Lee

    2015-05-01

    Full Text Available HT048 is a combination composed of Crataegus pinnatifida leaf and Citrus unshiu peel extracts. This study aimed to investigate potential anti-obesity effect of the combination. The 3T3-L1 adipocytes were treated with different doses of HT048 and triglyceride accumulation, glycerol release and adipogenesis-related genes were analyzed. For in vivo study, male Sprague Dawley rats were divided according to experimental diets: the chow diet group, the high-fat diet (HFD group, the HFD supplemented with orlistat group, the HFD supplemented with HT048 group (0.2% or 0.4% for 12 weeks. We measured the body weight, serum lipid levels and the expression of genes involved lipid metabolism. HT048 treatment dose-dependently suppressed adipocyte differentiation and stimulated glycerol release. The expressions of PPARγ and C/EBPα mRNA were decreased by HT048 treatment in adipocytes. HT048 supplementation significantly reduced the body and fat weights in vivo. Serum lipid levels were significantly lower in the HT048 supplemented groups than those of the HFD group. Expression of the hepatic lipogenesis-related genes were decreased and expression of the β-oxidation-related genes were increased in rats fed HT048 compared to that of animals fed HFD. These results suggest that HT048 has a potential benefit in preventing obesity through the inhibition of lipogenesis and adipogenesis.

  17. Una lectura comprensiva de la teoría espacial de David Harvey y Doreen Massey para el análisis de la formación ciudadana.

    OpenAIRE

    David Andrés Vidal López

    2015-01-01

     Resumen El presente artículo tiene como propósito inicial realizar una reflexión acerca de las potencialidades analíticas y conceptuales de la teoría espacial de Doreen Massey y David Harvey, en el análisis de la formación ciudadana y la construcción de subjetividades desde la escuela[1]. Para ello, se revisan los conceptos de Espacio y espacialidad que los autores han propuesto en dos de sus trabajos más representativos. Seguidamente, se analizan de manera muy sucinta algunos registros y ob...

  18. The Theoretical Characteristics of Historical-Geographical Materialism and Harvey's Theoretical Contribution%哈维对历史一地理唯物主义的理论建构

    Institute of Scientific and Technical Information of China (English)

    王雨辰; 张佳

    2012-01-01

    David Harvey is a theoretician of Later-Marxism. This article is intended to clarify his basic idea to construct the theory of historical-geographical materialism, and to compare his theory of historical-geographical materialism with Later-Marxism and Post-Marxism, so as to highlight its theoretical characteristics and Harvey' s theoretical contribution. Through a comparative study, we believe that, Harvey always adhered to historical materialism and Marx' s class theory, and from the spatial perspective, we reveal that late capitalist society is still dominated by the capital logic, so its class relations failed to change essentially. Therefore, as an important representative of Later-Marxism, Harvey not only adhered to the basic stance of historical materialism, but also opened up the new theoretical space for historical materialism, thus enriching and developing Marxism in the new historical conditions.%本文拟在厘清哈维建构历史一地理唯物主义理论思路的基础上,认为哈维属于晚期马克思主义理论家,并通过对比研究他与后马克思主义思潮的异同,凸显其理论特质和彰显其理论贡献。哈维始终坚持以生产方式为核心的历史唯物主义分析框架,从空间的视角揭示出晚期资本主义社会仍然是受资本逻辑支配,其阶级关系并没有发生本质改变。因此,作为晚期马克思主义重要代表的哈维没有像后马克思主义那样走向后现代主义政治,同时他开拓了历史唯物主义的理论空间。

  19. Biología, distribución e integración del alga alóctona Undaria pinnatifida (Laminariales, Phaeophyta en las comunidades bentónicas de las costas de Galicia (NW de la Península Ibérica

    Directory of Open Access Journals (Sweden)

    Cremades Ugarte, Javier

    2006-12-01

    Full Text Available Undaria pinnatifida is an Asian seaweed that is valuable as an edible species. This kelp was first reported for Spain in the 1980s on Galician coasts, where it is now widely distributed and incorporated into the native community. In Galicia, intertidal populations of the sporophytic phase typically inhabit sites under moderate wave-exposure in the early spring, albeit they can be found throughout the year as the species displays at least two recruitment periods per year. The morphology varies between individuals and depends strongly on the spatiotemporal pattern of environmental conditions. The chronology of the introduction of this species and the types of habitat where it is currently integrated on Galician coasts clearly reveal that the presence and local expansion of this kelp is influenced largely by human activities, mainly shellfish aquaculture and maritime traffic. U. pinnatifida has a slow natural expansion, limited aggressiveness and it temporarily fills empty niches; this kelp displays luxuriant growth only on artificial substrates or in otherwise disturbed communities.Undaria pinnatifida es una especie asiática de gran interés económico como alga alimentaria que en la década de los ochenta apareció por primera vez en España en las costas de Galicia, donde actualmente se encuentra ampliamente distribuida y naturalizada. Las poblaciones intermareales de los esporófitos de esta especie en la costa gallega son propias de localidades moderadamente expuestas a la acción del oleaje, siendo muy notorias a principios de primavera; aunque pueden encontrarse casi todoel año, al existir al menos dos períodos anuales de reclutamiento. La morfología de los ejemplares que las forman es muy variable y está fuertemente relacionada con las variaciones espaciotemporales de las condiciones ambientales. Analizando la cronología de su introducción en Galicia y los hábitats y tipos de comunidades en las que se integra, se observa claramente

  20. HYDRAULICS, HARVEY COUNTY, KS PMR

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Recent developments in digital terrain and geospatial database management technology make it possible to protect this investment for existing and future projects to...

  1. FLOODPLAIN, HARVEY COUNTY, KANSAS PMR

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Digital Flood Insurance Rate Map (DFIRM) Database depicts flood risk information and supporting data used to develop the risk data. The primary risk...

  2. Simultaneous determination of vitexin-2"-O-glucoside, vitexin-2"-O-rhamnoside, rutin, and hyperoside in the extract of hawthorn (Crataegus pinnatifida Bge.) leaves by RP-HPLC with ultraviolet photodiode array detection.

    Science.gov (United States)

    Cheng, Shan; Qiu, Feng; Huang, Jia; He, Junqi

    2007-03-01

    RP-HPLC with UV photodiode array detection (UV-DAD) was developed and validated for the simultaneous determination of vitexin-2"-O-glucoside, vitexin-2"-O-rhamnoside, rutin, and hyperoside in the extract of hawthorn (Crataegus pinnatifida Bge.) leaves. The analytes of interest were separated on a Diamonsil C18 column (250 x 4.6 mm id, 5 microm) with the mobile phase consisting of THF/ACN/methanol/ 0.05% phosphoric acid solution (pH 5.0) (18:1:1:80 v/vl/v). The flow rate was set at 1.0 mL/min and the eluent was detected at 340 nm for the four flavonoids. The method was linear over the studied range of 1.00-100 microg/mL for the four analytes of interest with the correlation coefficient for each analyte greater than 0.999. The LOD and LOQwere 0.03 and 0.10 microg/mL, 0.03 and 0.10 microg/mL, 0.05 and 0.15 pg/mL, 0.10 and 0.30 microg/mL for vitexin-2"-O-glucoside, vitexin-2"-0-rhamnoside, rutin, and hyperoside, respectively. The optimized method was successfully applied to the analysis of four important flavonoids in the extract of hawthorn leaves. The total amounts of the four flavonoids were 22.2, 62.3, 4.27, and 8.24 mg/g dry weight for vitexin-2"-O-glucoside, vitexin-2"-O-rhamnoside, rutin, and hyperoside in the extract of hawthorn leaves, respectively.

  3. Losing the Quality Battle in Australian Education for Librarianship: A Decade on. (An Update on the Original Article by Ross Harvey, "Losing the Quality Battle in Australian Education for Librarianship". "The Australian Library Journal", 50 No. 1, 2001: 15-22.)

    Science.gov (United States)

    Harvey, Ross

    2011-01-01

    The Editor of "ALJ" has invited me to comment on my 2001 article "Losing the quality battle in Australian education for librarianship" (Harvey 2001). The article was prompted by a period I spent as a visiting professor in the Department of Information Studies at UCLA (the University of California Los Angeles) and was written while I was there.…

  4. 大卫·哈维的后现代观--以其空间生产理论为视角%The Post-modern Idea of David Harvey--in the perspective of his spatial production

    Institute of Scientific and Technical Information of China (English)

    吴玲

    2013-01-01

      David Harvey, as an important representative of the neo-Marxist, developed post-modernism into“cultural - geographical postmodernism”based on the theory of spatial production perspective. That is to say, post-modernism is not only a kind of culture transfer, but also a kind of geographic phenomenon. By means of“time-space compression”experience, “Cultural - geographical postmodernism”explored the deeper cause of postmodernism, which is the transformation from the Ford socialist accumulation system to the Flexible accumulation system. From these information, David Harvey draw a conclusion that postmodern condition is a transfer of capitalist mode of production and culture, rather than the emergence of a new society.%  作为新马克思主义者重要代表的大卫·哈维以空间生产理论为视角,将后现代主义发展为一种“文化—地理后现代主义”,即后现代主义既是一种文化转移,又是一种地理现象;以“时空压缩”体验为中介,在探究后现代主义的深层根源:福特-凯恩斯主义向灵活积累体制的转变,得出结论,即后现代状况是资本主义生产方式与文化的一种转移,而非全新社会的出现。

  5. 裙带菜和萱藻凝集素对刺参组织主要免疫酶活性的影响%Effects of two lectins from Undaria pinnatifida and Scytosiphon lomentarius on the activities of immunoenzymes in Apostichopus japonicus

    Institute of Scientific and Technical Information of China (English)

    李丹彤; 谢广成; 李洪福; 邢殿楼; 王斌; 刘远; 姜峰; 胡昕江

    2011-01-01

    The effects of two lectins from Undaria pinnatifida and Scytosiphon lomentarius on the activities of acid phosphatase ( ACP ), alkaline phosphatase ( AKP ), lysozyme ( LSZ ) and catalase ( CAT ) of A.japonicus were studied by supplying various Undaria pinnatifida lectin or S. lomentarius lectin levels in diets. The experimental dietary levels of U. pinnatifida lectin were 0.58% (m/m) ,1.16% and 2.32% ,and those of S. lomentarius lectin were 0.32% ,0.64% and 1.28% ,respectively. Group fed with basic feed was set as control. On the 4th,8th,13th and 17th day after feeding,the activities of ACP,AKP,LSZ and CAT in A. japonicus were determined. The results indicated that the activity of ACP sustainably increased and was higher than the control among 17 days. The activities of LSZ increased firstly after lectins feeding except S.lomentarius lectin on 17th day, which decreased on this day, and the activities of LSZ were proportionally related to the additional dosage of two kinds of lectins. The CAT activity of U. pinnatifida lectin groups increased as the time went on, however CAT activity, firstly increased and then decreased in S. lomentarius lectin groups.%研究刺参基础饲料中添加不同剂量裙带菜凝集素和萱藻凝集素对刺参酸性磷酸酶(ACP)、碱性磷酸酶(AKP)、溶菌酶(LSZ)、过氧化氢酶(CAT)活性的影响.在基础饲料中分别添加0.58%、1.16%、2.32%裙带菜凝集素(质量分数);0.32%、0.64%、1.28%萱藻凝集素,以基础饲料饲组为对照,于投喂后第4、8、13、17天检测ACP、AKP、LSZ、CAT活性.结果显示,投喂17 d内,各实验组ACP活性随时间和剂量增加持续升高,ACP活性均高于对照组;LSZ活性则随时间延长持续升高,但萱藻凝集素各组活性在第17天有所下降,且LSZ活性与凝集素添加量成正比关系;裙带菜凝集素组CAT活性呈升高趋势,萱藻凝集素组呈先高后低规律变化.

  6. 环境·正义·阶级——略论戴维·哈维的空间正义思想%Environment · Justice· Class-- On David Harvey's Thought of Spatial Justice

    Institute of Scientific and Technical Information of China (English)

    李晓乐; 王英; 王志刚

    2012-01-01

    基于“过程辩证法”和“历史地理唯物主义”视角,哈维把差异性、身份和他性等后现代诉求植入到当前环境问题的分析中,试图在时空生产格局下复兴社会正义的解放性诉求。他将列斐伏尔的“空间的生产”推进到“自然的生产”,将正义维度嵌入环境和空间变迁过程中。哈维认为,资本主义生产方式下的“自然的生产”必然带来环境正义问题,因而任何替代资本主义的社会一政治规划都必须是生态的规划;全部对自然观点的批判性考察同时也是对社会的批判性考察。哈维有关环境正义的思想构成其空间正义理论的重要组成部分,他主张环境正义运动必须设法跨越社会关系间的界线,成为一种更加普遍的阶级行动和规划,即正义必须实现从特殊到普遍的转向,这至关重要;但他鼓吹的生态社会主义政治规划说到底仍然是一种理论姿态,环境正义运动要想在实际的政治斗争中产生直接的结果,还有一段漫长而艰难的道路。%Based on the process dialectic and historical--geographical materialism, Harvey put such postmodern appeal as respect for diversity, identity embedded into the current environment problem analysis, attempt to renaissance social justice liberation appeal in the production process of spatiotemporal pattern. He put the Lefebvre's "the production of space" to advance to "the production of natural " , put the justice dimension embedded in spatial and environmental changes. Harvey thinks, "the production of nature" in the capitalist mode will inevitably bring about the environmental justice issues, and thus any alternative to capitalism's social--political planning must be ecological planning; all the critical re- search on natural view is but also for the social critical investigation. Harvey's thought about environmental justice constitute an important part of the theory of justice, he

  7. 巴黎的神话:作为当代中国城市镜像——读大卫·哈维的《巴黎:现代性之都》%The Myth of Paris as Mirror of Contemporary Chinese Cities: Book Review on “Paris: Capital of Modernity”by David Harvey

    Institute of Scientific and Technical Information of China (English)

    杨宇振

    2011-01-01

    The paper reviews Paris: Capital of Modernity by David Harvey from three main aspects; research methodology, capitalism's historic context and the historic role of Haussmann,Paris's social process from 1830-1871 reconstructed by Harvey, and combines the text reading with the urban reality of contemporary China.%本文从方法论,资本主义发展的历史情境及奥斯曼个人在历史中的作用,哈维所重构的1830-1871年间巴黎城市社会过程三方面解读大卫·哈维的,并将文本解读与中国城市现实结合起来.

  8. 粗江蓠多糖对辐射损伤小鼠NK细胞的影响%Effect of Gracilaria Gigas Harvey Polysaccharides (GHPS) on Natural Killer Cells Activity in Mice with Radiation Injury

    Institute of Scientific and Technical Information of China (English)

    王亚飞; 孟庆勇

    2009-01-01

    目的:研究粗江蓠多糖(Gracilaria Gigas Harvey Polysaccharides, GHPS)对辐射损伤小鼠NK细胞的影响.方法:采用60Co γ射线5Gy全身照射小鼠制造辐射损伤模型,通过乳酸脱氢酶释放法检测不同剂量(10mg/kg,20mg/kg,40mg/kg)的GHPS对辐射损伤小鼠NK细胞杀伤靶细胞能力的影响.结果:辐射对照组小鼠接受60Co γ射线5Gy照射后,NK细胞的活性显著低于正常对照组(P<0.01).经腹腔注射(10、20、40 )mg/kg GHPS,再接受γ射线5Gy照射后,小鼠NK细胞活性明显高于辐射对照组(P<0.01),并有剂量依赖性.结论:5Gy γ射线可以抑制小鼠NK细胞杀伤靶细胞的活性,而GHPS对辐射损伤小鼠的NK细胞有保护作用.

  9. 阶级力量的重建:大卫·哈维新自由主义观述评%Restoration of Class Power: Neoliberalism from Neo -Marxist Perspective: A Review on David Harvey's View of Neoliberalism

    Institute of Scientific and Technical Information of China (English)

    易申波

    2012-01-01

    大卫·哈维是当代世界最主要的批判性知识分子和当代西方新马克思主义的重要代表人物之一。他对新自由主义的实质、产生与发展历程及其未来前景进行了深入的批判性考察。运用马克思主义的阶级分析方法,他发现新自由主义的实质不过是统治精英建立或重建阶级力量,这一结论对我们理解新自由主义无疑具有深刻的启发意义。%David Harvey is one of the leading critical intellectuals in the world and one of the most important representatives of con- temporary western Neomarxism. He has deeply probed into the essence, the development process and the future of neoliberalism. U- sing the Marxist class analysis method, he finds that the essence of neoliberalism is just the restoration of elite class power. This con- clusion enlightens us a lot in understanding neoliberalism.

  10. The Ethical Critique of Urban Space and Its Significance: A Case Study of David Harvey%城市空间的伦理学批判及其意义——以大卫·哈维为例

    Institute of Scientific and Technical Information of China (English)

    高春花; 孙希磊

    2011-01-01

    大卫·哈维从城市的居住分异、空间剥夺和空间异化三个方面展开了对西方社会城市空间的伦理学批判,揭示了资本主义城市空间不平等、不正义与土地资本及金融资本的内在关联性。大卫·哈维的城市空间伦理学批判理论给我们的启发是:在我国城市化进程中,应该用源自集体理性的公共选择规范资本运营,用健全的保障制度抑制空间分配不公,用价值理性引导城市空间消费。%David Harvey developed the ethical critique of Western urban space from three aspects:residential differentiation, space deprivation and space alienation. He revealed the inequality, injustice and intrinsic association between land capital and financial c

  11. 现代建筑的去人性化--兼论大卫·哈维的建筑伦理批判思想%De-humanized Modern Architecture:David Harvey's Ethical Criticism on Architecture

    Institute of Scientific and Technical Information of China (English)

    吴红涛

    2014-01-01

    David Harvey made a unique and profound thinking of the ethical criticism on the significance of architectural space. He analyzed the de-humanized representations of architecture ethic through criticizing the classification, performance and mediocrity of the modern architecture, and found the transition of moral criteria. In his opinion, de-humanized architecture wil corrupt ethical awareness, create the depravation of architecture and humanity.%对建筑空间价值意义的考察,不能脱离其伦理维度的评判。在这一点上,大卫·哈维做出了属于其独有而深刻的思考。通过对现代建筑等级化、表演化和平庸化的批判,哈维分析了建筑伦理的“去人性化”表征。在这些“去人性化”的现代建筑中,哈维敏感地发现了现代人类道德的时代渐变。在他看来,建筑的“去人性”,也能够腐化人类的伦理道德意识;建筑的堕落,同样也意味着人性的堕落。

  12. El álbum visual como nueva forma promocional de la industria de la música: el caso de Let England Shake de PJ Harvey y Seamus Murphy

    Directory of Open Access Journals (Sweden)

    Ana María Sedeño-Valdellós

    2016-01-01

    Full Text Available El nuevo modelo de negocio para la industria fonográfica comienza a basar se en los contenidos digitales. Varios autores han estudiado y afirman que la industria musical experimenta un giro hacia el contenido audiovisual. Esto se enmarca en una nueva etapa de estética audiovisual caracterizada por la transmedialidad y la convergencia de medios en torno a formatos audiovi suales complejos. El álbum visual, como concepto formado por videoclips de todas las canciones de un disco, se consolida como un nuevo formato de promocional musical, híbrido entre cine y video musical. En el traba jo se realizará un análisis del álbum visual Let England Shake (PJ Harvey & Seamus Murphy, 2011, con unos criterios que tratan de buscar moti vos visuales que generen continuidad, unidad temática y narrativa para de mostrar su intensa coherencia con el álbum musical precedente. Se trata de definir el álbum visual y comenzar a delimitarlo frente a otros tipos de productos audiovisuales, así como examinar sus posibilidades de creación de sentido en la generación de una narrativa personal diferenciada para un artista/grupo musical.

  13. Una lectura comprensiva de la teoría espacial de David Harvey y Doreen Massey para el análisis de la formación ciudadana.

    Directory of Open Access Journals (Sweden)

    David Andrés Vidal López

    2015-09-01

    Full Text Available  Resumen El presente artículo tiene como propósito inicial realizar una reflexión acerca de las potencialidades analíticas y conceptuales de la teoría espacial de Doreen Massey y David Harvey, en el análisis de la formación ciudadana y la construcción de subjetividades desde la escuela[1]. Para ello, se revisan los conceptos de Espacio y espacialidad que los autores han propuesto en dos de sus trabajos más representativos. Seguidamente, se analizan de manera muy sucinta algunos registros y observaciones, tomados de la práctica pedagógica del autor en el Centro Educativo Rural Olarte de la localidad de Usme en Bogotá, con estudiantes de diversos grados.  Estos registros hacen parte de las representaciones y concepciones que sobre la ruralidad, como espacio vivido expresan los estudiantes. De este modo se podrán abordar los dos contextos conceptuales (escuela-espacio, y de este modo comprender las posibilidades de un ejercicio político escolar dinámico, constructor de subjetividades y de respeto por la diferencia y la diversidad.[1] El presente texto hace parte de una reflexión paralela al proyecto de investigación “Representaciones sociales y cultura política en el CED Rural Olarte: una aproximación etnográfica para pensar la formación ciudadana”, actualmente en curso dentro del programa de Maestría en educación de la Universidad Nacional de Colombia.

  14. Review on "Urbanization of Capital " Written by David Harvey%马克思主义与城市问题结合研究的典范——大卫·哈维的《资本的城市化》述评

    Institute of Scientific and Technical Information of China (English)

    叶超

    2011-01-01

    新马克思主义城市学派是影响二战后西方社会科学界的一个重要流派,大卫·哈维是其代表人物.在《资本的城市化》中,他将马克思主义理论和方法应用于城市(化)问题,演绎出城市空间组织和结构是资本生产的需要和产物的总结论,揭示了资本主义城市化是资本集聚和阶级斗争矛盾作用的过程的实质,并将其延伸到对整个资本主义政治经济的批判和分析,从而发展了马克思主义的城市理论.该学派理论对忽视马克思主义理论与城市问题之间联系的我国学界尤具借鉴价值.%The new Marxism urban school is one of the important western theories after World War II. David Harvey is the representative figure of this school. In his work "urbanization of capital" , Harvey applies Marxism theories and methods to the urban problem, deduces that the urban spatial organization and structure are the production of capital, and reveales the capitalist urbanization are a contradictory process of capital accumulation and class struggle. Harvey extends this kind of theories to the whole criticism and analysis for capitalist political and economic system, and develops Marxist theories on city. These theories are especially important for Chinese scholars, because they often ignore the connections between the urban problems and Marxism theories.

  15. “过程辩证法”与“总体性的辩证法”——大卫·哈维与卢卡奇的辩证法思想比较%"Dialectics of Process" and "Dialectics of Totality" --The Compare of Dialectic Idea between David Harvey and LukOcs

    Institute of Scientific and Technical Information of China (English)

    郝胤舟

    2012-01-01

    Being Marxists, David Harvey and Lukacs have many things in common in their dialectical thoughts. However, due to different social backgrounds, they differ much in many aspects. Fundamentally, the dialectical thought of David Harvey is "the dialectics of process", while that of Lukacs is "the dialectics of totality", so the difference between their dialectical thoughts is that of "the dialectics of process" and "the dialectics of totality".%大卫·哈维与卢卡奇的辩证法思想有着许多相同之处。同时,由于他们所处的社会背景不同,他们的辩证法思想也必然有着很大的区别。从根本上讲,大卫·哈维的辩证法思想是“过程的辩证法”,而卢卡奇的辩证法思想是“总体性的辩证法”。

  16. Basemap Framework Submission for Harvey County, KS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — FEMA Framework Basemap datasets comprise six of the seven FGDC themes of geospatial data that are used by most GIS applications (Note: the seventh framework theme,...

  17. DCS Survey Submission for Harvey County, KS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — Survey data includes spatial datasets and data tables necessary to digitally represent data collected in the survey phase of the study. (Source: FEMA Guidelines and...

  18. 大卫·哈维空间理论的政治诉求--一种“时空辩证乌托邦”的建构%David Harvey's Political Appeal of Space Theory---A Construction of “Spatiotemporal Dialectical Utopianism”

    Institute of Scientific and Technical Information of China (English)

    李逢铃

    2015-01-01

    随着社会理论之空间转向成为学术热点,大卫·哈维及其思想也早已渐入中国学者视野之中,特别是其“历史-地理唯物主义”已成为对历史唯物主义挑战的经典改造。然而,在整个后现代话语氛围中,哈维不仅停留于理论的质疑和批判,更为可贵之处在于其试图以“时空辩证乌托邦”为理想实现某种建构。这也是哈维思想往往被学者所忽视的一面。当然,这种建构是依附于马克思主义理论,从地理学的视角对《共产党宣言》的重新解读,并提出重振“全世界无产者,联合起来”的口号。同时,通过解构“全球化”神话,以不平衡地理发展理论为基点实现全球宏观空间和身体微观空间的有机结合。这种解构和回归,有力的抨击了新自由主义“退步乌托邦”的建构。最终,以反叛建筑师的设想,在批判空间形式和社会过程两种乌托邦形式的基础上,提出了建构时空辩证乌托邦理想。虽然这种建构最终也导向了另一种形式的空想,然而哈维强烈的主体性反思、反教条式的独特视角以及斗争的乐观心态、勇气等等都是值得我们批判性学习的。%As social theory of space turn becomes academic focus,David Harvey and his thoughts are getting into the vision of Chinese scholars.In particular,his “historical-geography materialism”has become a classical renovation for historical materialism.However,in the whole atmosphere of the post-modern discourse,Harvey not only questioned and criticized the theory,but also tried to achieve some kind of construction through dialectical utopianism,which tended to be overlooked by other scholars. Certainly,based on the Marxist theory,this construction re-interpreted Communist Manifesto from the perspective of geography and proposed to revive the slogan of “proletarians of the world,unite”.At the same time,by deconstructing the myth of

  19. Change of Capital Accumulation and Space-time Compression:David Harvey's Diagnosis of Post Modernism%资本变式与时空压缩:大卫·哈维对后现代主义的诊断

    Institute of Scientific and Technical Information of China (English)

    朱晓庆

    2015-01-01

    〔Abstract〕As one of the most influential Marxist in the west, David Harvey's research on post modernism is no longer limited to ideological criticism or cultural criticism, but also explains the inner mechanism prospered in the culture of post modernism from the position of Marx's political and economic critique. It shows that the post modernist is not a sign of the emergence of a new post capitalist society, but a continuation of modernism. It is of significance for us to deepen the study of Marxism in the post modernist issues.%作为当代西方最有影响力的马克思主义者之一,大卫·哈维对后现代主义的研究思路不再拘泥于思想批判或文化批判,而是秉承了马克思主义政治经济学批判立场,深入阐释了后现代主义文化兴起的内在机制:资本积累的变式与人们时空体验的变化。由此表明,后现代主义并不是全新的后资本主义社会出现的一种标志,而是现代主义的某种延续。这对我们在后现代主义议题上深化马克思主义的研究具有启示意义。

  20. Cultivation of Undaria pinnatifida in Liaodong peninsula: irradiance control, ambient temperature changes vs.gametogenesis in seedling production process%辽东半岛裙带菜室内常温全人工育苗:双高光控制、温度变化和配子体发育

    Institute of Scientific and Technical Information of China (English)

    逄少军; 单体锋; 刘明泰; 张艳; 许淑芬

    2011-01-01

    Undaria pinnatifida is a commercially important seaweed in China with a more than 30 years of farming history. However, artificial seedling production of this seaweed has not yet been stable. How to control the light intensity according to seasonal changes of temperature is the key to the success of artificial seedling production in practice. In this investigation, we report our large-scale indoor artificial production of seedlings by use of spores at room temperature in Liaodong peninsula, the major farming area of U. Pinnatifica in China, mainly on how to control irradiance levels during the 3-month period. According to the requirements of the gametogenesis resulted from our previous studies, we adopted two high irradiance phases (≥50 μmol photons /m2 · S) at the beginning and the ending stage. The first high light phase started from seeding of zoospores and ended at the beginning of over-summering phase. This period allowed a full growth of male and female gametophytes. The second high light phase, starting from the end of the over-summering period to the end of the seedling production, allowed a rapid gametogenesis and formation of sporophytes. Under suitable irradiance the gametophytes were able to complete gametogenesis and produce normal young sporophytes even at temperature as high as 24 ℃. The optimal temperature for the growth of young sporophytes was 20 ~ 22 ℃. 2~5 mm sporophytes could temporarily tolerate 24 - 26 ℃ , however, the smaller they were, the higher the capacity they demonstrated in tolerating higher temperature. Real-time manipulation of irradiance according to the temperature changes and the development of gametophytes over a period of 3 months generated very good results of seedlings on strings in 2010. This investigation will shed light on improvement of techniques in terms of seedling production in this region.%2010年,作者在辽东半岛成功进行了裙带菜室内常温全人工育苗大规模生产试验,并全程进行

  1. 社会化媒体与空间的社会化生产--戴维·哈维“空间压缩思想”的当代阐释%Social Media and Social Production of Space:A Contemporary Interpretation of David Harvey's Thoughts of Space Compression

    Institute of Scientific and Technical Information of China (English)

    刘涛

    2014-01-01

    David Harvey generalized the spatial experience as space compression under the circumstance of capitalistic global expansion . The process of space compression , which is presenting the unprecedented and productive experience of compression , was based on the social production of space within the context of social media . By bringing space into social relational structure , the essence of space compression is to redefine the concept and practice of space through exploring , utilize and reconstruct all kinds of spatial forms of fragmentized space , as well as through design and produce the visibility of space and the hyperspace . Based on the process of de-ritualization and re-ritualization of everyday life , the cultural result of space compression appears as the declining trend of traditional ethical emotion .%戴维·哈维将资本主义全球扩张下的空间体验概括为“空间压缩”。社会化媒体语境下,“空间压缩”建立在空间的社会化生产基础上,并且呈现出前所未有的“压缩”体验和生产趋势。“空间压缩”的实质是将空间纳入到社交关系结构中,通过对各种碎片化的缝隙空间形态的发掘、利用和重组来打破甚至消灭各种空间障碍,并在“可见性”与“超空间”的精心设计中重构人们的空间观念和空间实践。这一过程是通过对现实生活的“去仪式化”和“再仪式化”双重改造完成的,其直接的文化后果是传统伦理情感的渐趋消失。

  2. Surgical triumvirate of Theodor Kocher, Harvey Cushing, and William Halsted.

    Science.gov (United States)

    Modlin, I M

    1998-01-01

    It is difficult to evaluate precisely the effects of one individual on an entire discipline such as surgery. Indeed, it is impossible to do so when such a discipline spans so vast a country as the United States of America. Nevertheless, as a mountain peak can be seen from afar, so may one perceive the influence of man of Kocher's stature. His connection with Halsted and especially Cushing provided a direct link between the grandeur of Kocher's achievements and their lineal translation to a generation of evolving American surgeons. Both individuals, by personal example and professional endeavor, transmitted the precepts of Kocher to the nascent surgical fellowship of America. Thus the icon of Swiss surgery, recognized by a Nobel laureate and esteemed by his European colleagues, became a profound influence on American surgery. The triumvirate of Kocher, Cushing, and Halsted may thus be acknowledged as of vital consequence to the establishment of American surgery during the twentieth century.

  3. The Fontan circulation: a challenge to William Harvey?

    Science.gov (United States)

    de Leval, Marc R

    2005-04-01

    The Fontan operation, which places the systemic and pulmonary circulations in series and is driven by a single ventricular chamber, is the treatment of choice for patients born with one ventricle. Its introduction 35 years ago was the result of a flurry of experimental and clinical research that had started in the 1940s. A large number of children have benefited and continue to benefit from the Fontan operation, but there is a genuine concern that, despite the refinement of the surgical procedures in the past 20 years, continuing attrition might be inevitable. This adverse effect can lead to a decline in functional capacity, and premature late death.

  4. The discovery of pulmonary circulation: From Imhotep to William Harvey.

    Science.gov (United States)

    ElMaghawry, Mohamed; Zanatta, Alberto; Zampieri, Fabio

    2014-01-01

    In his quest to comprehend his existence, Man has long been exploring his outer world (macro-cosmos), as well as his inner world (micro-cosmos). In modern times, monmental advances in the fields of physics, chemistry, and other natural sciences have reflected on how we understand the anatomy and physiology of the human body and circulation. Yet, humanity took a long and winding road to reach what we acknowledge today as solid facts of cardiovascular physiology. In this article, we will review some of the milestones along this road.

  5. Harvey W. Cushing and cerebrovascular surgery: Part I, Aneurysms.

    Science.gov (United States)

    Cohen-Gadol, Aaron A; Spencer, Dennis D

    2004-09-01

    The development of surgical techniques for the treatment of intracranial aneurysms has paralleled the evolution of the specialty of neurological surgery. During the Cushing era, intracranial aneurysms were considered inoperable and only ligation of the carotid artery was performed. Cushing understood the limitations of this approach and advised the need for a more thorough understanding of aneurysm pathology before further consideration could be given to the surgical treatment of cerebral aneurysms. Despite his focus on brain tumors, Cushing's contributions to the discipline of neurovascular surgery are of great importance. With the assistance of Sir Charles Symonds, Cushing described the syndrome of subarachnoid hemorrhage. He considered inserting muscle strips into cerebral aneurysms to promote aneurysm sac thrombosis and designed the "silver clip," which was modified by McKenzie and later used by Dandy to clip the first intracranial aneurysm. Cushing was the first surgeon to wrap aneurysms in muscle fragments to prevent recurrent hemorrhage. He established the foundation on which pioneers such as Norman Dott and Walter Dandy launched the modern era of neurovascular surgery.

  6. DIGITAL FLOOD INSURANCE RATE MAP DATABASE, HARVEY COUNTY, KANSAS

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Digital Flood Insurance Rate Map (DFIRM) Database depicts flood risk information and supporting data used to develop the risk data. The primary risk...

  7. DIGITAL FLOOD INSURANCE RATE MAP DATABASE, HARVEY COUNTY, KANSAS, USA

    Data.gov (United States)

    Federal Emergency Management Agency, Department of Homeland Security — The Digital Flood Insurance Rate Map (DFIRM) Database depicts flood risk information and supporting data used to develop the risk data. The primary risk...

  8. Primary Study on Raft Culture Technique of Gracilaria gigas Harvey%粗江蓠(Gracilaria gigas Harvey)浮筏式养殖技术初探

    Institute of Scientific and Technical Information of China (English)

    林位琅

    2002-01-01

    由台湾引进粗江蓠种,在罗源湾海区采用浮筏式开展养殖试验,对养殖海区的水温、盐度、pH值、光照等环境因子适宜条件,进行初步的探索,并取得阶段性成果。

  9. Changes in physicochemical characteristics and free amino acids of hawthorn (Crataegus pinnatifida) fruits during maturation.

    Science.gov (United States)

    Li, Wei-Qin; Hu, Qing-Ping; Xu, Jian-Guo

    2015-05-15

    In this study, changes in physicochemical characteristics associated with fruit quality and free amino acids were investigated during maturation of hawthorn fruits. Significant differences in these parameters were found during maturation. The color turned progressively from mature green to semi-red, to reach bright red; the shape changed gradually from oval to round or approached round; the size, weight, and edible part (flesh/core ratio) of hawthorns increased while the density of intact fruits did not change. The content of moisture, total soluble sugars, soluble pectin, reduced ascorbic acid, total ascorbic acid, fructose, and sucrose increased while crude protein content decreased significantly. The levels of starch, sucrose, titratable acidity, protopectin, pectin, total free amino acids, and total essential amino acids initially increased and then decreased gradually during maturation. The outcomes of this study provide additional and useful information for fresh consumption and processing as well as utilization of dropped unripe hawthorn fruits. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. [Determination of Mg and Zn contents of Naruto "wakame" (Undaria pinnatifida)].

    Science.gov (United States)

    Ito, S; Miyoshi, T

    1990-08-01

    The contents of Mg and Zn in the sea-weed "wakame" were determined and compared at different growth stages, in different parts, for different root cultivation intervals, and in processed foods. The results obtained were as follows: 1. Mg (2.09-2.60 g/100 g) and Zn (8.00-10.76 mg/100 g) contents were independent of growth stage with the exception of Zn (29.00-35.78 mg/100 g) in the natural young "wakame". 2. The mineral contents of leaves, stipes, fruiting bodies and rhizoids of "wakame" at different growth stages were determined. The contents of Mg (1.00-2.36 g/100 g) and Zn (3.93-12.01 mg/100 g) were richer in leaves and stipes than in fruiting bodies and rhizoids. 3. Densely cultured "wakame" showed higher contents of Zn (6.73 mg/100 g) than thinly cultured plants (5.99 mg/100 g), and Mg content was not affected by changes in environmental conditions. 4. The Mg/Ca ratios reached a maximum in the stipe (3.3) and at fruiting bodies (2.9) in the middle stage, and in the base of the stipe of the mature plant (3.5). 5. Contents of the minerals in processed foods were determined. "Suboshi" was rich in Mg (1.07 +/- 0.42 g/100 g), and "Haiboshi" was rich in Zn (10.90 +/- 1.20 mg/100 g). The mineral contents in "Enzo" were small.

  11. Extraction and Identification of Phlorotannins from the Brown Alga, Sargassum fusiforme (Harvey) Setchell

    Science.gov (United States)

    Li, Yajing; Fu, Xiaoting; Duan, Delin; Liu, Xiaoyong; Xu, Jiachao; Gao, Xin

    2017-01-01

    Phlorotannins are a group of complex polymers of phloroglucinol (1,3,5-trihydroxybenzene), which are unique compounds from marine brown algae. In our present study, a procedure for extraction and enrichment of phlorotannins from S. fusiforme with highly antioxidant potentials was established. After comparison of different extraction methods, the optimal extraction conditions were established as follows. The freeze-dried seaweed powder was extracted with 30% ethanol-water solvent with a solid/liquid ratio of 1:5 at temperature of 25 °C for 30 min. After extraction, the phlorotannins were fractioned by different solvents, among which the ethyl acetate fraction exhibited both the highest total phlorotannin content (88.48 ± 0.30 mg PGE/100 mg extract) and the highest antioxidant activities. The extracts obtained from these locations were further purified and characterized using a modified UHPLC-QQQ-MS method. Compounds with 42 different molecular weights were detected and tentatively identified, among which the fuhalol-type phlorotannins were the dominant compounds, followed by phlorethols and fucophlorethols with diverse degree of polymerization. Eckol-type phlorotannins including some newly discovered carmalol derivatives were detected in Sargassum species for the first time. Our study not only described the complex phlorotannins composition in S. fusiforme, but also highlighted the challenges involved in structural elucidation of these compounds. PMID:28230766

  12. Harvey Nursing Home Terenure, 122-124 Terenure Road West, Terenure Road, Dublin 6w.

    LENUS (Irish Health Repository)

    Shi, Weifeng

    2010-12-01

    More and more nucleotide sequences of type A influenza virus are available in public databases. Although these sequences have been the focus of many molecular epidemiological and phylogenetic analyses, most studies only deal with a few representative sequences. In this paper, we present a complete analysis of all Haemagglutinin (HA) and Neuraminidase (NA) gene sequences available to allow large scale analyses of the evolution and epidemiology of type A influenza.

  13. 2014 Williams Harvey Lecture: importance of coronary vasomotion abnormalities-from bench to bedside.

    Science.gov (United States)

    Shimokawa, Hiroaki

    2014-12-01

    Coronary vasomotion abnormalities play important roles in the pathogenesis of ischaemic heart disease, in which endothelial dysfunction and coronary artery spasm are substantially involved. Endothelial vasodilator functions are heterogeneous depending on the vessel size, with relatively greater role of nitric oxide (NO) in conduit arteries and predominant role of endothelium-derived hyperpolarizing factor (EDHF) in resistance arteries, where endothelium-derived hydrogen peroxide serves as an important EDHF. The functions of NO synthases in the endothelium are also heterogeneous with multiple mechanisms involved, accounting for the diverse functions of the endothelium in vasomotor as well as metabolic modulations. Cardiovascular abnormalities and metabolic phenotypes become evident when all three NO synthases are deleted, suggesting the importance of both NO and EDHF. Coronary artery spasm plays important roles in the pathogenesis of a wide range of ischaemic heart disease. The central mechanism of the spasm is hypercontraction of vascular smooth muscle cells (VSMCs), but not endothelial dysfunction, where activation of Rho-kinase, a molecular switch of VSMC contraction, plays a major role through inhibition of myosin light-chain phosphatase. The Rho-kinase pathway is also involved in the pathogenesis of a wide range of cardiovascular diseases and new Rho-kinase inhibitors are under development for various indications. The registry study by the Japanese Coronary Spasm Association has demonstrated many important aspects of vasospastic angina. The ongoing international registry study of vasospastic angina in six nations should elucidate the unknown aspects of the disorder. Coronary vasomotion abnormalities appear to be an important therapeutic target in cardiovascular medicine.

  14. Harvey Nursing Home Terenure, 122-124 Terenure Road West, Terenure Road, Dublin 6w.

    LENUS (Irish Health Repository)

    Thomas, Warren

    2012-02-01

    The steroid hormone aldosterone is a key regulator of electrolyte transport in the kidney and contributes to both homeostatic whole-body electrolyte balance and the development of renal and cardiovascular pathologies. Aldosterone exerts its action principally through the mineralocorticoid receptor (MR), which acts as a ligand-dependent transcription factor in target tissues. Aldosterone also stimulates the activation of protein kinases and secondary messenger signaling cascades that act independently on specific molecular targets in the cell membrane and also modulate the transcriptional action of aldosterone through MR. This review describes current knowledge regarding the mechanisms and targets of rapid aldosterone action in the nephron and how aldosterone integrates these responses into the regulation of renal physiology.

  15. Designing a Utopia: An Architectural Studio Experience on David Harvey's "Edilia"

    Science.gov (United States)

    Yesilkaya, Nese Gurallar

    2008-01-01

    The design of a utopia was devised as a studio project in order to bring critical thinking into the design studio and to stimulate creativity. By suggesting a utopia, the pedagogical aim was to improve progressive thinking and critical thought in the design education of architectural students -- and also future architects. From this perspective,…

  16. Harvey Prize Lecture: The calm before the storm: the link between quiescent cavities and CMEs

    Science.gov (United States)

    Gibson, S. E.

    2005-05-01

    Coronal mass ejections (CMEs) are thought to be driven by magnetic energy, stored in twisted or sheared magnetic fields. Magnetic clouds, which are interplanetary manifestations of CMEs, are commonly modeled as flux ropes of twisted magnetic field. It has also become quite standard to model the erupting CME as a flux rope. However, the question of whether the flux rope is formed during the eruption, or whether the flux rope existed prior to the eruption, remains controversial. CMEs often possess a three-part morphology in white light observations of a bright front, followed by a relatively dark cavity, and lastly a bright core associated with an erupting prominence. The three-part structure of CMEs has been shown in a variety of models to be a consequence of a magnetic flux rope topology. The same physical reasons for the presence of the cavity system in eruption hold true in quiescence, and so it is significant that the three-part structure, in the form of helmet-streamer/cavity/prominence-core often exists quiescently in the corona. I will present an analysis of a few case studies of white light quiescent cavities as observed by the HAO Mauna Loa Solar Observatory Mk4 coronagraph. In particular I will consider the 3D structure and evolution of these cavities, and how these are related to CMEs. Finally, I will discuss the implications that these observations may have for the state of the corona just prior to a CME, and more generally for the nature of coronal MHD equilibria.

  17. High-Density Genetic Linkage Map Construction and Quantitative Trait Locus Mapping for Hawthorn (Crataegus pinnatifida Bunge).

    Science.gov (United States)

    Zhao, Yuhui; Su, Kai; Wang, Gang; Zhang, Liping; Zhang, Jijun; Li, Junpeng; Guo, Yinshan

    2017-07-14

    Genetic linkage maps are an important tool in genetic and genomic research. In this study, two hawthorn cultivars, Qiujinxing and Damianqiu, and 107 progenies from a cross between them were used for constructing a high-density genetic linkage map using the 2b-restriction site-associated DNA (2b-RAD) sequencing method, as well as for mapping quantitative trait loci (QTL) for flavonoid content. In total, 206,411,693 single-end reads were obtained, with an average sequencing depth of 57× in the parents and 23× in the progeny. After quality trimming, 117,896 high-quality 2b-RAD tags were retained, of which 42,279 were polymorphic; of these, 12,951 markers were used for constructing the genetic linkage map. The map contained 17 linkage groups and 3,894 markers, with a total map length of 1,551.97 cM and an average marker interval of 0.40 cM. QTL mapping identified 21 QTLs associated with flavonoid content in 10 linkage groups, which explained 16.30-59.00% of the variance. This is the first high-density linkage map for hawthorn, which will serve as a basis for fine-scale QTL mapping and marker-assisted selection of important traits in hawthorn germplasm and will facilitate chromosome assignment for hawthorn whole-genome assemblies in the future.

  18. Effects of pretreatments on anthocyanin composition, phenolics contents and antioxidant capacities during fermentation of hawthorn (Crataegus pinnatifida) drink.

    Science.gov (United States)

    Liu, Suwen; Chang, Xuedong; Liu, Xiufeng; Shen, Zhanwei

    2016-12-01

    The effect of microwave and heat pretreatment on the content and composition of anthocyanins, phenolics, and the antioxidant capacity of hawthorn drink were studied. Nine anthocyanins were isolated by chromatographic separation from the Zirou hawthorn source and their structure identified using HPLC-DAD-ESI/MS analysis. Heat and microwave pretreatments had a significant impact on the relative contents of hawthorn anthocyanins, such as cyanidin-3-galactoside (82.9% and 76.9%, respectively) and cyanidin-3-glucoside (9.2% and 11.5%, respectively). Pretreatment had no significant effect on pH, total soluble solid or total acid. More anthocyanins remained after heat treatment than after microwaving (0.745mg/100mL), and were 52.4% higher than the control group after storage for 7days. The colour density of the heat treated group was higher than the control group (24.5%) after 12days of fermentation. The main antioxidant capacities of the hawthorn drinks came from total polyphenolics rather than total anthocyanins or total flavonoids. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. De Reclus a Harvey, la resignificación del territorio en la construcción de la sustentabilidad

    Directory of Open Access Journals (Sweden)

    Arturo V. Arreola Muñoz

    2017-01-01

    Full Text Available El objetivo de este artículo es reflexionar teórica y conceptualmente sobre el territorio y su resignificación en la construcción de la sustentabilidad. Se hace referencia a la teoría de sistemas complejos, desde un enfoque constructivista, y de la geografía y la ecología política, como aproximación a las nociones de apropiación territorial, territorialización, desterritorialización y reterritorialización. La discusión deductiva de cinco tesis concluye con un postulado que retoma la propuesta de Gunderson y Holling (2002, para explicar los procesos adaptativos de los sistemas socioterritoriales, los cuales están mediados a partir de cadenas dialógicas. Actualmente, desde los movimientos sociales emergentes, se tejen innovaciones que recrean de manera híbrida conceptos como diversidad, autonomía, equidad y sustentabilidad. Ello permite resignificar el diálogo político del paradigma por el territorio entre los espacios de esperanza –redes antisistémicas–, los exclusivos –redes globalizadas– y los de desesperanza –espacios fragmentados–.

  20. Milk (2008 and The Times of Harvey Milk (1984: The Double Filmic Resurrection of the Mayor of Castro Street

    Directory of Open Access Journals (Sweden)

    Sara Villa

    2010-11-01

    This paper aims at analyzing the ways in which this double filmic reappearance of Milk's political figure reactivates his piercing political activism in two different, but similarly crucial historical moments for the GLBT community, and contributes to the affirmation of an illuminated gay icon within the overall fight for human rights.

  1. On the shoulders of giants: Harvey Cushing's experience with acromegaly and gigantism at the Johns Hopkins Hospital, 1896-1912.

    Science.gov (United States)

    Pendleton, Courtney; Adams, Hadie; Salvatori, Roberto; Wand, Gary; Quiñones-Hinojosa, Alfredo

    2011-03-01

    A review of Dr. Cushing's surgical cases at Johns Hopkins Hospital revealed new information about his early operative experience with acromegaly. Although in 1912 Cushing published selective case studies regarding this work, a review of all his operations for acromegaly during his early years has never been reported. We uncovered 37 patients who Cushing treated with surgical intervention directed at the pituitary gland. Of these, nine patients who presented with symptoms of acromegaly, and one with symptoms of gigantism were selected for further review. Two patients underwent transfrontal 'omega incision' approaches, and the remaining eight underwent transsphenoidal approaches. Of the 10 patients, 6 were male. The mean age was 38.0 years. The mean hospital stay was 39.4 days. There was one inpatient death during primary interventions (10%) and three patients were deceased at the time of last follow-up (33%). The mean time to death, calculated from the date of the primary surgical intervention, and including inpatient and outpatient deaths, was 11.3 months. The mean time to last follow-up, calculated from the day of discharge, was 59.3 months. At the time of last follow-up, two patients reported resolution of headache; four patients reported continued visual deficits, and two patients reported ongoing changes in mental status. This review analyzes the outcomes for 10 patients who underwent surgical intervention for acromegaly or gigantism, and offers an explanation for Cushing's transition from the transfrontal "omega incision" to the transsphenoidal approach while practicing at the Johns Hopkins Hospital.

  2. On the shoulders of giants: Harvey Cushing's experience with acromegaly and gigantism at the Johns Hopkins Hospital, 1896-1912.

    NARCIS (Netherlands)

    Pendleton, C.; Adams, H.; Salvatori, R.; Wand, G.; Quinones-Hinojosa, A.

    2011-01-01

    A review of Dr. Cushing's surgical cases at Johns Hopkins Hospital revealed new information about his early operative experience with acromegaly. Although in 1912 Cushing published selective case studies regarding this work, a review of all his operations for acromegaly during his early years has ne

  3. Maailm võitleb sooja kliima tekitatud kahjuga / Scheherazade Daneshkhu, Fiona Harvey ; tõlk. Erik Aru

    Index Scriptorium Estoniae

    Daneshkhu, Scheherazade

    2006-01-01

    Kliimamuutuse majanduslik käsitlus on maha jäänud, kulu-tulu analüüsi kasutamine keskkonnakahju hindamisel on tekitanud probleeme, ÜRO on hakanud propageerima "looduslikku kapitali" keskkonnahüviste hindamiseks. Maailmapanga endise peaökonomisti Sir Gordon Browni juhtimisel valmib kliimamuutuse majandusmõjude ülevaade. Lisa: Emissioonikaubanduse raamistik; Korporatsioone sunnitakse tegudele

  4. Sharing a life with Harvey: Exploring the acceptance of and relationship-building with a social robot

    NARCIS (Netherlands)

    de Graaf, M.M.A.; Ben Allouch, Soumaya; Klamer, T.

    2015-01-01

    Social robots will become ubiquitous in our everyday environments. These robots could potentially extend life expectancy, and improve the health and quality of life of an aging population. A long-term explorative study has been conducted by installing a social robot for health promotion in elderly

  5. Cellular Phone Towers, Cell Towers, Published in 2007, 1:4800 (1in=400ft) scale, Harvey County.

    Data.gov (United States)

    NSGIC GIS Inventory (aka Ramona) — This Cellular Phone Towers dataset, published at 1:4800 (1in=400ft) scale, was produced all or in part from Orthoimagery information as of 2007. It is described as...

  6. Maailm võitleb sooja kliima tekitatud kahjuga / Scheherazade Daneshkhu, Fiona Harvey ; tõlk. Erik Aru

    Index Scriptorium Estoniae

    Daneshkhu, Scheherazade

    2006-01-01

    Kliimamuutuse majanduslik käsitlus on maha jäänud, kulu-tulu analüüsi kasutamine keskkonnakahju hindamisel on tekitanud probleeme, ÜRO on hakanud propageerima "looduslikku kapitali" keskkonnahüviste hindamiseks. Maailmapanga endise peaökonomisti Sir Gordon Browni juhtimisel valmib kliimamuutuse majandusmõjude ülevaade. Lisa: Emissioonikaubanduse raamistik; Korporatsioone sunnitakse tegudele

  7. On the shoulders of giants: Harvey Cushing's experience with acromegaly and gigantism at the Johns Hopkins Hospital, 1896-1912.

    NARCIS (Netherlands)

    Pendleton, C.; Adams, H.; Salvatori, R.; Wand, G.; Quinones-Hinojosa, A.

    2011-01-01

    A review of Dr. Cushing's surgical cases at Johns Hopkins Hospital revealed new information about his early operative experience with acromegaly. Although in 1912 Cushing published selective case studies regarding this work, a review of all his operations for acromegaly during his early years has ne

  8. 维莱(Wiley,Harvey Washington,1844-1930)美国化学家(Chemist,America)

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    维莱1871年在印弟安纳医学院学习,1873年在哈弗大学获学士学位,1878年在柏林大学进修。1874-1883任普尔都大学化学教授。他的主要贡献是食品分析和制定改进的食品法规。主要著作有:《美国的制糖工业》(1885)、《农业分析的原理和实践》(1894-1897)、《食品及食品掺假》(1907-1912)、《反食品法规的犯罪史》(1929)、《自传》(1930)等。

  9. "Adventures of Harvey" - Use, Acceptance of and Relationship Building with a Social Robot in a Domestic Environment

    Science.gov (United States)

    Klamer, Tineke; Ben Allouch, Somaya; Heylen, Dirk

    The goal of this study was to improve our understanding about how older people use social robots in domestic environments and in particular whether and how they build relationships with these robots. Three participants interacted with the Nabaztag, a social robot, for a 10-day period in their own home environment. Some of our findings are (1) utilitarian-, hedonic-, and social factors are important when accepting social robots, (2) utilitarian-, hedonic- and social factors are important for building a relationship with the Nabaztag, (3) there is a relationship between name-calling and relationship building and (4) there is a relationship between using non-verbal- and verbal communication and relationship building.

  10. Comparative effects of hawthorn (Crataegus pinnatifida Bunge) pectin and pectin hydrolyzates on the cholesterol homeostasis of hamsters fed high-cholesterol diets.

    Science.gov (United States)

    Zhu, Ru-Gang; Sun, Yan-Di; Li, Tuo-Ping; Chen, Gang; Peng, Xue; Duan, Wen-Bin; Zheng, Zheng-Zheng; Shi, Shu-Lei; Xu, Jing-Guo; Liu, Yan-Hua; Jin, Xiao-Yi

    2015-08-05

    This study aims to compare the effects of feeding haw pectin (HP), haw pectin hydrolyzates (HPH), and haw pectin pentasaccharide (HPPS) on the cholesterol metabolism of hypercholesterolemic hamsters induced by high-cholesterol diets. The animals were fed a standard diet (SD), high-cholesterol diet (HCD), or HCD plus HP, HPH, or HPPS at a dose of 300mg/kg body weight for 4weeks. Results showed that HPPS was more effective than HP and HPH in decreasing the body weight gain (by 38.2%), liver weight (by 16.4%), and plasma and hepatic total cholesterol (TC; by 23.6% and 27.3%, respectively) of hamsters. In addition, the bile acid levels in the feces were significantly higher by 39.8% and 132.8% in the HPH and HPPS groups than in the HCD group. Such changes were not noted in the HP group. However, the HP group had higher cholesterol excretion capacities than the HPH and HPPS groups by inhibiting cholesterol absorption in the diet, with a 21.7% increase in TC excretion and a 31.1% decrease in TC absorption. Thus, HPPS could be a promising anti-atherogenic dietary ingredient for the development of functional food to improve cholesterol metabolism. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  11. 大孔吸附树脂纯化山楂叶总黄酮%Purification of Flavoniods of Leaves of Crataegus Pinnatifida Bge. By Macroporous Adsorption Resin

    Institute of Scientific and Technical Information of China (English)

    吴华; 奚玉石; 张守勤; 梁清

    2008-01-01

    研究D101大孔吸附树脂分离纯化山楂叶总黄酮的工艺条件以及参数, 为山楂叶总黄酮的工业化生产提供参考.通过静态和动态试验相结合,对D101大孔树脂吸附纯化山楂叶总黄酮性能考察, 以吸附和洗脱性能参数为考察指标综合评价,证明D101大孔吸附树脂对山楂叶总黄酮有良好的吸附分离效果,适于山楂叶总黄酮的纯化.结果表明:树脂对山楂叶总黄酮的饱和吸附量为78mg/g ,山楂叶总黄酮主要集中在10%~70%乙醇洗脱液中;山楂叶提取物上D101树脂柱床,以水、10%乙醇洗脱后以70%乙醇洗脱,最终产品中山楂叶总黄酮纯度达82%,总黄酮收率达98%,说明采用D101大孔树脂分离纯山楂叶黄酮可行.

  12. Studies on anti-tumor activities of Undaria Pinnatifida polysaccharides(UPPS)%裙带菜多糖抗肿瘤作用的研究

    Institute of Scientific and Technical Information of China (English)

    王雪; 邹向阳; 郭莲英; 邢嵘; 毕向东; 侯林

    2006-01-01

    [目的]观察裙带菜多糖的体内、外抗肿瘤作用,并对其机制进行讨论.[方法]采用MTT法观察裙带菜多糖体外对人肝癌细胞 HepG-2的抑制作用;通过对615荷瘤小鼠瘤重及免疫器官脾脏的研究,观察了裙带菜多糖的体内抗肿瘤作用.[结果]与阴性对照组相比裙带菜多糖各浓度组体外对人肝癌细胞 HepG-2均有很强的抑制作用(P<0.01),其中15、10 mg/mL组的抑制率分别为57.20%、51.79%,略低于5-FU组;在荷瘤小鼠实验中,与空白对照组相比裙带菜多糖各浓度组均有很强的肿瘤抑制作用,其中400、200 mg/kg组抑瘤率分别为69.13%、42.11%,与5-FU组相近.[结论]裙带菜多糖对人肝癌细胞 HepG-2抑制效果显著,小鼠体内实验也证实了裙带菜多糖较强的抗肿瘤作用.

  13. Scale insects from the Netherlands Antilles

    NARCIS (Netherlands)

    Reyne, A.

    1964-01-01

    The following species have been reported from the Netherlands’ Antilles: Margarodes formicarum Guilding, collected in 1884 or 1885 by Prof. W. F. R. Suringar in Curaçao; specimens in the State Museum of Natural History at Leiden. Protortonia cacti (Linn.), collected in 1756 by Daniel Rolander in St.

  14. Scale insects from the Netherlands Antilles

    NARCIS (Netherlands)

    Reyne, A.

    1964-01-01

    The following species have been reported from the Netherlands’ Antilles: Margarodes formicarum Guilding, collected in 1884 or 1885 by Prof. W. F. R. Suringar in Curaçao; specimens in the State Museum of Natural History at Leiden. Protortonia cacti (Linn.), collected in 1756 by Daniel Rolander in St.

  15. PDE inhibitors--Second William Harvey Research Conference. Drugs with an expanding range of therapeutic uses. 1-3 December 1999, Nice, France.

    Science.gov (United States)

    Torphy, T J

    2000-02-01

    This meeting underscored advances in the exploitation of cyclic nucleotide phosphodiesterases (PDEs) as drug targets. One highlight of the meeting was the disclosure of a new PDE isozyme, bringing to 11 the total number of genetically distinct isozyme families thus far identified. Also reported was the phenotypic characterization of a PDE4D murine genetic knockout. With respect to drug discovery and development, the most encouraging information presented centered on advances in targeting PDE4 with therapeutically useful inhibitors. Historically, the therapeutic utility of isozyme-selective PDE4 inhibitors has been limited by class-associated side effects, namely nausea and dyspepsia. New PDE4 inhibitors are being designed with the specific intent of improving upon the therapeutic ratio of first-generation agents. The profiles of two second-generation PDE4 inhibitors, SB-207499 (Ariflo; Smithkline Beecham plc) and PD-189659, were presented. SB-207499 demonstrated marked efficacy in phase II clinical trials in patients with moderate-to-severe chronic obstructive pulmonary disease (COPD), a disease of very high unmet medical need. PD-189659 has yet to enter clinical trials, but its preclinical profile indicates that this agent can produce substantial anti-inflammatory effects without producing class-associated side effects in animal models. A number of presentations were also given on the utility of PDE5 inhibitors in the treatment of male erectile dysfunction (MED). The widespread use of Viagra (sildenafil; Pfizer Inc) over the last year has reinforced the perception that PDE5 inhibitors are safe and effective agents for the treatment of MED. The overall tenor of the meeting was distinctly upbeat, with most participants believing that PDE isozymes are becoming ever more accessible as targets for drug discovery in a variety of therapeutic areas.

  16. West Bank of the Mississippi River in the Vicinity of New Orleans, Louisiana (East of the Harvey Canal) Hurricane Protection Study. Technical Appendixes. Volume 2

    Science.gov (United States)

    1994-08-01

    Richard Baker Honorable Robert L Livingston Honorable William Jefferson FEDERAL AGENCIES Federal Emergency Mgmt Administration Mr John Seyffert, National...construction of the Project, together with the right to trim, cut, fell and remove therefrcm all trees, nmzertush, obstr =ions, and any other vegetation...District and the Corps of the Corps of Engineers for getting the project to this point. Ms. Stephpnie Edwards, Congressman William Jefferson’s Office Ms

  17. On David Harvey's Theory of "Time-Spatial Fix"%大卫·哈维的"时间-空间修复"理论

    Institute of Scientific and Technical Information of China (English)

    唐旭昌

    2010-01-01

    当代国外马克思主义的代表人物大卫·哈维从"时间-空间修复"的视角对"资本主义为什么能长久地生存下来"这一问题进行了解答.哈维认为,"时间的加速和空间的缩减"是资本主义运动的一项基本法则;"时间-空间修复"是资本主义维持其统治的重要工具;而全球化策略则是资本主义世界性扩张的一种空间策略.这些都深刻地表明,资本主义是通过"时间-空间修复"的策略而维持至今的.

  18. 戴维·哈维的新帝国主义理论探析%On David Harvey's Theory of New Imperialism

    Institute of Scientific and Technical Information of China (English)

    田世锭

    2010-01-01

    戴维·哈维是当代英美辩证法马克思主义的重要代表,他是运用辩证法马克思主义所主张和坚持的"内在关系的辩证法"来论证新帝国主义的.所以,按照哈维的新帝国主义理论,新帝国主义之"新"就在于它是由处于内在关系之中的领土逻辑与资本逻辑共同作用的产物,其核心和主要特征是剥夺性积累.应当说代替这种新帝国主义的仍然是社会主义,但反对新帝国主义、实现社会主义的斗争必须将扩大再生产领域无产阶级的斗争与反抗剥夺性积累的斗争辩证地结合起来.

  19. On David Harvey's Critique of Capital from Space Vision%大卫·哈维空间视域的资本批判理论

    Institute of Scientific and Technical Information of China (English)

    李春火

    2010-01-01

    大卫·哈维在转向马克思主义以后开启了空间视域的资本批判并将这一批判思想不断推进着.列斐伏尔空间哲学思想传统和马克思资本批判思想传统是其思想渊源.哈维通过空间视域的资本批判,论述了后现代发展状况的时空背景与资本主义的时空经验的新形式、资本的"过度积累"与新自由主义欲求通过"剥夺性积累"实现"空间修复"、新自由主义的资本主义"空间修复"的失败及"希望的空间"的可能性的未来愿景等问题.哈维空间视域的资本批判理论对我们来说具有重要的理论和现实意义,但它也具有一定的理论局限.

  20. 论大卫·哈维的辩证乌托邦思想%Discussion over David Harvey's Dialectical Utopia

    Institute of Scientific and Technical Information of China (English)

    唐旭昌

    2010-01-01

    在乌托邦思想和乌托邦运动越来越受到人们的冷遇、忽视甚至嘲笑的当今,著名的马克思主义城市地理学家大卫·哈维却对乌托邦进行了执着的追求.他主张一种时空统一的辩证乌托邦,并将其作为新的社会替代方案的理论基础.哈维的辨证乌托邦思想超越了社会过程乌托邦和空间形式乌托邦的局限,具有一定的历史进步性;但是,他用"社区实践"作为社会替代方案的核心时却抛弃了阶级斗争理论,因此他的社会替代方案不具有现实性.

  1. A Probe into David Harvey's New Marxist Spatial Theory%大卫·哈维的新马克思主义空间理论探析

    Institute of Scientific and Technical Information of China (English)

    章仁彪; 李春敏

    2010-01-01

    "空间及其生产"始终是大卫·哈维关注的核心问题,作为当代西方有影响力的马克思主义学者,哈维秉承了马克思主义空间探索传统.将空间问题作为理解当今资本主义社会的重要方面,并尝试将空间作为一个积极的因素纳入到历史唯物主义的分析和阐述框架之中,这个逻辑主线贯穿于哈唯关于"空间与资本积累"、"不平衡地理发展"、"时空压缩与弹性积累"的理论分析中.哈维的分析视角是多维的,其研究领域涉及当代社会的各种空间形态,从"全球化"到"日常生活"、从"资本积累的全球经济空间"到"后现代的文化空间",而马克思主义始终是哈维空间分析的方法论基础.在各种后现代主义、后结构主义的话语强势中,哈维开辟了一条新的空间批评话语,提供了一条推进马克思主义理论当代化有益思路和启示.

  2. 大卫·哈维的不平衡地理发展理论述评%Comments on the Theory of David Harvey's Uneven Geographical Development

    Institute of Scientific and Technical Information of China (English)

    董慧

    2008-01-01

    不平衡地理发展是涉及诸多领域,如社会学、地理学、历史学、人类学、政治学、经济学等理论和实践中的核心问题之一。正是作为新自由主义政治规划和资本积累地理过程的全球化与多样性之间的冲突,越来越使我们认识到不平衡地理发展的重要性及其在当代政治实践的基础性地位。

  3. 大卫·哈维的空间正义思想探析%David Harvey's Thought of Space Justice

    Institute of Scientific and Technical Information of China (English)

    张佳

    2015-01-01

    在对空间正义问题的探讨上,传统研究大都关注于如何在分配领域实现城市空间资源的公平配置.大卫·哈维的空间正义思想超越了传统空间正义理论.他一方面深刻揭示了由资本主导的空间生产是造成空间分配不公的根源,主张只有改变资本主义生产关系,实现生产正义,才可能真正实现分配正义.另一方面,他将空间正义的研究主题从城市空间正义进一步拓展到了全球空间正义和环境正义.哈维的空间正义思想具有积极的当代意义.

  4. The understanding and operative treatment of cerebral palsy at the turn of the twentieth century: Harvey Cushing's early forays into pediatric neurosurgery.

    Science.gov (United States)

    Dmetrichuk, Jennifer M; Pendleton, Courtney; Ahn, Edward S; Quiñones-Hinojosa, Alfredo

    2011-09-01

    At the turn of the twentieth century, cerebral palsy and its treatment were not well understood, and a variety of treatment modalities were tested with only limited success. Following IRB approval and through the courtesy of the Alan Mason Chesney Archives, we reviewed the Johns Hopkins Hospital surgical files from 1896-1912. Eight patients who received a diagnosis consistent with cerebral palsy and were treated surgically by Dr. Cushing were selected for further analysis and are described here. A total of eight patients underwent operative intervention for treatment of symptoms consistent with cerebral palsy. Of these, seven were male; the mean age was 4.9 years (range, 1.5 to 12). Five patients underwent decompressive craniotomies, one underwent tenotomies, one underwent transection of the spinal nerve roots, and one underwent primary transection of the spinal nerve roots with secondary tenotomies. Four representative cases are reported here. Cushing's contributions to pediatric neuro-oncology have been previously described, but his endeavors in non-oncologic realms remain largely unknown. Although Cushing employed previously described operative approaches for the treatment of cerebral palsy, parents brought their children to him from across the nation, in an era when long distance travel was tedious, and a financial burden. These cases serve to emphasize Cushing's interest in improving patient quality of life, and his broad contributions to pediatric neurosurgery.

  5. 77 FR 46287 - Safety Zone; Gulf Intracoastal Waterway, Mile Marker 35.2 to Mile Marker 35.5, West of Harvey...

    Science.gov (United States)

    2012-08-03

    ... implications for federalism. 6. Protest Activities The Coast Guard respects the First Amendment rights of... Order 12630, Governmental Actions and ] Interference with Constitutionally Protected Property Rights. 9... passage through the Safety Zone must request permission from the Captain of the Port Morgan City, or a...

  6. 33 CFR 117.451 - Gulf Intracoastal Waterway.

    Science.gov (United States)

    2010-07-01

    ... Waterway. (a) The draw of the Lapalco Boulevard Bridge, Harvey Canal Route, mile 2.8 at Harvey, shall open... 59.9 west of Harvey Lock, at Houma, shall open on signal; except that, the draw need not open for the... 319 (Louisa) bridge across the Gulf Intracoastal Waterway, mile 134.0 west of Harvey Lock,...

  7. Macroalage as a source of alpha-glucosidase inhibitors

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Alpha-glucosidase inhibitors were screened from organic solvent extracts of macroalgae by a spectrophotometrical method with p-nitrophenyl-D-glucopyranosidase as the substrate. The result indicates that organic crude extracts from some macroalgae such as Rhodomela confervoides (Huds.) Silva, Gracilaria textorii (Suringar) DeToni, Plocamium telfairiae Harv., Dictyopteris divaricata (Okam.) Okam, Ulval pertusa and Enteromorpha intestinalis (L.) Link et al. show strong inhibitory activity of alpha-glucosidase at concentration of 79.6 μg/ml.

  8. Effects of pectin pentaoligosaccharide from Hawthorn ( Crataegus pinnatifida Bunge. var. Major) on the activity and mRNA levels of enzymes involved in fatty acid oxidation in the liver of mice fed a high-fat diet.

    Science.gov (United States)

    Li, Tuo-Ping; Zhu, Ru-Gang; Dong, Yin-Ping; Liu, Yong-Hui; Li, Su-Hong; Chen, Gang

    2013-08-07

    The regulatory effects of haw pectin pentaoligosaccharide (HPPS) on fatty acid oxidation-related enzyme activities and mRNA levels were investigated in the liver of high fat diet induced hyperlipidemic mice. Results showed that HPPS (150 mg/kg for 10 weeks) significantly suppresses weight gain (32.3 ± 0.26 and 21.1 ± 0.14 g for high-fat diet and HPPS groups, respectively), decreases serum triacylglycerol levels (1.64 ± 0.09 and 0.91 ± 0.02 mmol/L, respectively), and increases lipid excretion in feces (55.7 ± 0.38 and 106.4 ± 0.57 mg/g for total lipid, respectively), compared to high-fat diet as control. HPPS significantly increased the hepatic fatty acid oxidation-related enzyme activities of acyl-CoA oxidase, carnitine palmitoyltransferase I, 3-ketoacyl-CoA thiolase, and 2,4-dienoyl-CoA reductase by 53.8, 74.2, 47.1, and 24.2%, respectively. Meanwhile, the corresponding mRNAs were up-regulated by 89.6, 85.8, 82.9, and 30.9%, respectively. Moreover, HPPS was able to up-regulate the gene and protein expressions of peroxisome proliferator-activated receptor α. Results suggest that continuous HPPS ingestion may be used as dietary therapy to prevent obesity and cardiovascular diseases.

  9. 裙带菜多糖UPPS-C2初级结构分析及活性初探%Primary Structure Analysis and Activity Study of Undaria pinnatifida Polysaccharide UPPS-C2

    Institute of Scientific and Technical Information of China (English)

    王福玲; 杨波; 季宇彬

    2011-01-01

    目的 分析裙带菜多糖UPPS-C2结构,并研究其体外抗肿瘤活性.方法 用Sephadex G-200凝胶柱色谱法和高效液相凝胶色谱法鉴定UPPS-C2纯度,用UV、IR、H-NMR、GC-MS等方法研究其初级结构,并采用MTT法测定裙带菜粗多糖和UPPS-C2对SGC-7901及HepG-2的抑制作用.结果 UPPS-C2多糖、硫酸基、葡糖醛酸含量分别为75.60%、9.23%和9.63%,不含蛋白质和核酸.为以α-吡喃糖为骨架的多糖,分子内存在羧基(-COOH)和硫酸基(-O-SO).单糖组成及质量分数比为岩藻糖:木糖:甘露糖:葡萄糖:半乳糖:塔罗糖=2.608:5.802:6.440:29.020:36.970:19.160.当其浓度为1000 μg/mL时,对SGC-7901和HepG-2的抑制率分别为33.85%、74.28%.结论 UPPS-C2为单一纯净的酸性杂多糖,对肿瘤细胞具有体外细胞毒作用,且活性较粗多糖好.%Objective To analyze the structure of UPPS-C2 and study its antitumor activity in vitro.Methods The purity of UPPS-C2 was identified by Sephadex G-200 gel column chromatography and HPGPC.The primary structure was studied by UV, IR, 1H-NMR, GC-MS methods and the inhibitory effects of UPPS and UPPS-C2 on SGC-7901 and HepG-2 were determined by MTT method.Results The contents of UPPS-C2, sulfate, glycuronic acid were 75.60 %,9.23 % and 9.63 %, respectively, and there were no protein and nucleic acid in UPPS-C2.The framework of UPPS-C2 was α-pyranose that contained carboxyl radical and sulfate radical in the molecule.UPPS-C2 was composed of fucose,xylose, mannose, glucose, galactose and talose, and the mass fraction ratio was 2.608∶ 5.802∶ 6.440∶ 29.020∶ 36.970∶19.160.The inhibitory rates on SGC-7901 and HepG-2 were 33.85 % and 74.28 % when the concentration of UPPS-C2 was 1 000 μg/mL.Conclusion As a homogeneous acidic heterosaccharide, UPPS-C2 has the activity of antitumor in vitro and the activity is better than that of UPPS.

  10. Determination of the Sulfated Group ofSulfated Polysaccharides in Polysaccharides from the Undaria Pinnatifida(UPPS)%裙带菜多糖中硫酸基含量的测定

    Institute of Scientific and Technical Information of China (English)

    张大雷; 葛炳艳; 李建; 张斌; 吴亚; 杨波

    2012-01-01

    目的:采用硫酸钡比浊法测定裙带菜多糖中硫酸基的含量,并对测定方法进行了研究.结果:用紫外可见分光光度法检测最大吸收波长为360nm,在0-24μg/mL范围内线性关系良好(r=0.9997).此方法的精密度良好(RSD为2.9%),具有较好的重复性(RSD为2.58%),同一样品在10-40min内的检测值比较稳定,回收率为(95.75±2.56)%.经测定,裙带菜多糖的硫酸基含量为10.58%.结论:该方法应用于裙带菜多糖硫酸基含量时结果比较准确,处理速度快,并且灵敏度较高.

  11. Study on Blood Pressure-lowering Effect of Undaria pinnatifida Dietary Fiber and Its Mechanism%裙带菜膳食纤维降血压及机制研究

    Institute of Scientific and Technical Information of China (English)

    肖红波; 卢向阳; 孙志良; 罗志峰; 易金娥

    2009-01-01

    40只大鼠分为4组(n=10):正常对照组、自发性高血压大鼠组、膳食纤维低剂量组(5%)、膳食纤维高剂量组(10%).经裙带菜膳食纤维处理8w后,检测离体血管的内皮依赖性舒张效应、尾动脉收缩压、血浆一氧化氮(NO)水平,并用Western印迹检测内皮型一氧化氮合酶(eNOS)蛋白表达水平,发现裙带菜可溶性膳食纤维显著降低尾动脉收缩压,显著改善内皮功能及血浆NO的水平并伴随着eNOS蛋白表达水平的上调.这些结果表明,裙带菜膳食纤维能降低自发性高血压大鼠的尾动脉收缩压,这可能与增加NO的产生来改善其内皮功能有关.

  12. Both Sides Now

    DEFF Research Database (Denmark)

    Pagh, Jesper

    2013-01-01

    Commentary on David Harvey: Spaces of Hope, Graham & Marvin: Splintering Urbanism and Hans Ibelings: Shifts......Commentary on David Harvey: Spaces of Hope, Graham & Marvin: Splintering Urbanism and Hans Ibelings: Shifts...

  13. 76 FR 40600 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2011-07-11

    ..., Amdt 1 Harvey, ND, Harvey Muni, RNAV (GPS) RWY 29, Orig-A Eastland, TX, Eastland Muni, RNAV (GPS) RWY..., David Wayne Hooks Memorial, LOC RWY 17R, Amdt 2 Lockhart, TX, Lockhart Muni, GPS RWY 18, Orig,...

  14. ALS Association

    Science.gov (United States)

    ... ALS and their families in areas affected by Hurricane Harvey. Learn More The ALS Association Disaster Relief Fund ... ALS and their families in areas affected by Hurricane Harvey. Learn More Our Mission To discover treatments and ...

  15. American Heart Association

    Science.gov (United States)

    ... can teach us about disrupted cardiac care after Hurricane Harvey. Hearty Humor by Jonny Hawkins After decades on ... 1 right away. Resources for those affected by Hurricane Harvey News View All Oklahoma smoking rate at all- ...

  16. Accreditation Association for Ambulatory Health Care

    Science.gov (United States)

    ... Healthcare Consultants International AAAHC Surveys paused due to Hurricane Harvey AAAHC September Achieving Accreditation AAAHC Apply for the ... AAAHC pauses survey activity in areas affected by Hurricane Harvey learn more » New AAAHC Tool Addresses Flexible Endoscope ...

  17. Porphyrins and Porphyria Diagnosis

    Science.gov (United States)

    ... open Tuesday, September 6, 2017 Aug 30, 2017 Hurricane Harvey and Office Closure Update Aug 28, 2017 Office Closed due to Hurricane Harvey Aug 24, 2017 Research Volunteers Needed » More recent ...

  18. American Association for the Study of Liver Diseases

    Science.gov (United States)

    ... Calendar to iCal What's New AASLD Statement on Hurricane Harvey Aug 29 The leadership and staff of AASLD ... who continue to face the devastating effects of Hurricane Harvey. Choledocholithiasis: Causes, symptoms, and diagnosis Aug 14 Choledocholithiasis ...

  19. Hormone Health Network

    Science.gov (United States)

    ... Resource Menopause Map™ View Today’s Spotlight Assistance for Hurricane Harvey If you or your loved ones have been impacted by the devastation of Hurricane Harvey, view our list of resources that are available ...

  20. American College of Obstetricians and Gynecologists

    Science.gov (United States)

    ... Statement from ACOG President-Elect Lisa Hollier on Hurricane Harvey Apply Now for Obesity Medicine Certification: Early Application ... Statement from ACOG President-Elect Lisa Hollier on Hurricane Harvey Discussions and Counseling About Obesity Should Begin in ...

  1. TRICARE, Military Health System

    Science.gov (United States)

    ... Emergency Declared in Louisiana and Texas due to Hurricane Harvey The governors of Louisiana and Texas have declared a State of Emergency due to Hurricane Harvey. Special procedures are in place for emergency refills ...

  2. American Lung Association

    Science.gov (United States)

    ... Washington DC West Virginia Wisconsin Wyoming Impacted by Hurricane Harvey? We're here to help. Call our Lung ... more events Latest News Protecting Your Health After Hurricane Harvey August 31, 2017 For Download: Keeping Your Lungs ...

  3. Porphyria Treatment Options

    Science.gov (United States)

    ... open Tuesday, September 6, 2017 Aug 30, 2017 Hurricane Harvey and Office Closure Update Aug 28, 2017 Office Closed due to Hurricane Harvey Aug 24, 2017 Research Volunteers Needed » More recent ...

  4. MotherToBaby

    Science.gov (United States)

    ... experts behind the most up-to-date research! Hurricane Harvey & Baby Are you Pregnant (or Breastfeeding) and Affected by Hurricane Harvey? MotherToBaby experts have answers to your questions. Get ...

  5. Erythropoietic Protoporphyria (EPP) or Protoporphyria

    Science.gov (United States)

    ... open Tuesday, September 6, 2017 Aug 30, 2017 Hurricane Harvey and Office Closure Update Aug 28, 2017 Office Closed due to Hurricane Harvey Aug 24, 2017 Research Volunteers Needed » More recent ...

  6. Research on Construction Technology of Harvey Tile Roof for Wood Frame in Madoura,Mozambique%莫桑比克马多拉市木屋架块瓦屋面施工技术研究

    Institute of Scientific and Technical Information of China (English)

    杨永现

    2016-01-01

    介绍了非洲国家莫桑比克的马多拉市国基理想城项目通过就地取材,采用当地沼泽土烧制的块瓦完成木屋架瓦屋面的施工工艺,并对所用块瓦坡屋面设计作了详细阐述;该项目主体结构安全可靠、屋面防水效果良好、建筑外观整洁典雅;探讨了中国防水市场进驻非洲国家的可行性,提出了相关对策.

  7. 空间的去人性化——从大卫·哈维看空间理性的缘起%Dehumanization of Space——Origin of Space Rationality via David Harvey

    Institute of Scientific and Technical Information of China (English)

    吴红涛

    2013-01-01

    对空间理性缘起的价值考察是大卫·哈维空间思想的重要组成部分.通过重审文艺复兴时期的透视法,哈维发现传统空间的“观看之道”在此转变,空间被各种理性印象所内化,其被视为个体解放与技术文明所利用的对象.在启蒙运动与现代性规划的双重推进下,空间理性在建筑、自然等多个领域得以体现.而空间由此所蕴含的客观性、实用性与技术性也吸引了“权力”的渗透,空间与权力的结盟使空间理性的行为实践逐步“异化”,进而导致了空间的去人性化表征.

  8. On David Harvey's Critique of Neo-liberalism and Enlightenment%大卫·哈维对新自由主义的批判及其启示

    Institute of Scientific and Technical Information of China (English)

    吴宁; 冯琼; 冯旺舟

    2013-01-01

    大卫·哈维揭示了新自由主义在地理上的不平衡发展的现实,指出新自由主义的实质是以资本的积累和扩张为核心的经济理论与意识形态,其目的就是维护资本主义私有制和实现资本主义国家的霸权,是垄断资产阶级维护自身权力的工具.哈维对新自由主义的批判,加深了对资本主义及其发展形态的认识,具有重要的启示意义.

  9. 论大卫·哈维空间视域下的阶级理论%On the Class Theory of David Harvey from the Perspective of Space

    Institute of Scientific and Technical Information of China (English)

    高海艳; 祝黄河

    2013-01-01

    哈维以马克思的资本积累理论为基础,创立“时空修复理论”,以空间透视当代资本主义社会的资本积累进程,分析当代资本主义国家如何通过空间生产、空间分配和空间消费,不仅使工人阶级依旧处在资本主义的剥削链条上,而且使资本主义剥削的范围扩张到了全球.哈维用阶级的空间斗争取代阶级的经济斗争,论证了当代资本主义剥削本质未变,马克思主义的阶级理论依然有效,反驳了新自由主义者对马克思主义阶级理论的挑战.

  10. 论大卫·哈维的城市空间思想及其现实意义%On the Urban Space Theory of David Harvey and ItsPractical Significance

    Institute of Scientific and Technical Information of China (English)

    张继龙

    2016-01-01

    近年来,西方马克思主义领域掀起一股关注城市问题的思潮.与传统马克思主义将城市看成附属性的考察对象相比,新马克思主义城市学派从空间维度重新彰显城市的主体性地位.作为该学派代表之一,大卫·哈维将马克思主义资本理论与空间思想有机结合起来,探索出研究城市问题的方法论——过程辩证法和“历史—地理唯物主义”,并根据该方法研究资本对城市空间的重塑问题,最后从城市空间的资本化、城市与阶级运动的关系和城市空间想象等三个方面对未来城市建设作出富有创见的预测.一定程度上来说,哈维的城市思想与当前中国特色城市发展道路具有一致性,这种一致性表现在:城市空间的资本化、异质化、区域化.因此,中国城市发展道路需要特别重视城市空间规划的科学性和系统性,城市人文精神的传承性和凝聚性,城市治理能力的现代性和开放性.

  11. ON DAVID HARVEY'S ACADEMIC CONSTRUCTION OF MARTIN HEIDEGGER'S THOUGHTS ON "PLACE"%论哈维对海德格尔“地方”思想的一次学术建构

    Institute of Scientific and Technical Information of China (English)

    张骁鸣

    2013-01-01

    大卫·哈维在收录于其《正义、自然与差异地理学》文集中的《从空间到地方,再回看》这篇文章中,对他所谓的马丁·海德格尔“地方建构”思想进行了批判.通过忠实地引用哈维和海德格尔的著作、分析其各自观点形成的背景并提供依据,本文详尽揭示了哈维在勾勒海德格尔思想这一学术工作中的操作细节,即他实际上大量使用了重排引文、重组素材、偷换主题、“视而不见”、模糊处理等做法,“制造”出一个需要批判的所谓海德格尔的“地方建构”思想,从而对自己所要提出的“地方建构”思想加以支持.仅就目前所掌握的文献看,海德格尔有他自己的“地方”和“空间”思想,但并未明确讨论过甚至从没有提到过哈维所关心的“地方建构”问题.

  12. 大卫·哈维空间视域中的资本批判及其启示%On David Harvey's Critique of Capital from Space Vision and Its Modern Significance

    Institute of Scientific and Technical Information of China (English)

    王明哲

    2013-01-01

    在资本主义城市问题突显的现实背景以及城市地理学和马克思主义双重理论背景下,大卫·哈维试图将马克思主义理论引入空间分析,形成了空间视域的资本批判理论.尽管哈维对马克思主义缺乏空间维度这一说法颇有欠缺,但他从资本积累的维度阐述了城市物质景观变迁和阶级关系再生产的新特征.哈维将资本批判引入空间理论的成果继承了马克思主义分析方法,丰富了马克思主义的内容,并为城市空间理论提供了新思路,同时也为中国解决城市问题提供了一种启示.

  13. 时空之间——哈维关于现代主义与后现代主义的思索%Between Space and Time: David Harvey's Thinking about Modemism and Postmodemism

    Institute of Scientific and Technical Information of China (English)

    崔丽华

    2011-01-01

    20世纪中叶,时空体验的不同构成了现代主义和后现代主义的严格的界限."现代性=时间,后现代=空间",几乎成为后现代思想家的共识.对于这一问题,马克思主义地理学家哈维并不像后现代主义者那样片面重视空间而忽视时间的意义,而是运用马克思主义政治经济学,在历史唯物主义的框架内,提出了时空压缩,充分揭示了时间和空间在现代主义与后现代主义变迁中的辩证互动关系.

  14. On David Harvey's Inquiry into the Spatial Issues%批评理论的空间转向--论戴维·哈维对空间问题的探寻

    Institute of Scientific and Technical Information of China (English)

    程世波

    2005-01-01

    自勒菲弗与福柯以来,空间成了审视现代性与后现代性的重要视域.哈维对空间问题的探寻,其最独特的贡献是将空间与空间性构造的生产综合为马克思主义理论的积极因素,并因此把历史唯物主义推进到历史-地理唯物主义的高度.以此为基础,哈维对城市空间、后现代性状况、全球化与身体等现象进行了十分精彩的解读.

  15. 哈维空间区域经济理论对皖江城市带建设的启示%David Harvey's Theory of Uneven Geographical Development and Its Enlightenment to the Construction on Wanjiang City Belt

    Institute of Scientific and Technical Information of China (English)

    张继龙

    2014-01-01

    哈维的空间区域经济理论基于空间视角和地理学理论,研究在区域经济全球化背景下的资本积累和资本主义权力政治逻辑以及二者之间的复杂关系,并认为资本主义发展具有不平衡性和永久破坏性,区域经济体是这种不平衡地理环境下的相对稳定的状态,国家制度安排,文化价值的统一等方面有助于区域的稳定.哈维的理论对皖江城市带建设有重要的启示:优先发展金融服务业,促进资本的自由流动;优化投资结构,调整产业结构;加快交通和通讯建设,缩短时空差距;加强文化建设,实现区域经济结构的一致性;做好国家顶层规划,加强区域之间的协调.

  16. Time-space Characteristics from the Point of Time-space Compression of David Harvey%从哈维时空压缩理论探讨时空的现状及其特性

    Institute of Scientific and Technical Information of China (English)

    郝亚楠

    2014-01-01

    哈维的“时空压缩理论”从社会时间的角度出发,将时间和空间的全新体验结合起来,阐释全球化进程下的时代文化变迁.通过哈维的时空压缩理论,人们能进一步的感受社会变化所带来的利与弊,在日常生产生活中体味到时空压缩的现实表征,感受时空全新的特性.

  17. 75 FR 79393 - Notice of Lodging of Settlement Agreement Under the Comprehensive Environmental Response...

    Science.gov (United States)

    2010-12-20

    ... Liability Act Notice is hereby given that on December 14, 2010, a proposed Harvey & Knott Consent Decree and Settlement Agreement (``Harvey & Knott Settlement Agreement'') in the bankruptcy matter, Motors Liquidation... Harvey & Knott Settlement Agreement are debtors Motors Liquidation Corporation, formerly known as...

  18. 78 FR 26679 - Kansas Disaster #KS-00073

    Science.gov (United States)

    2013-05-07

    ..., Dickinson, Ellis, Franklin, Harper, Harvey, Hodgeman, Kingman, Marion, Mcpherson, Ness, Osage, Osborne, Pawnee, Phillips, Pratt, Rice, Rooks, Rush, Russell, Smith, Stafford. The Interest Rates are: Percent For...

  19. 76 FR 12981 - Lower Mississippi River Waterway Safety Advisory Committee; Meeting

    Science.gov (United States)

    2011-03-09

    ... Warrant Officer David Chapman, Assistant to the DFO of Lower Mississippi River Waterway Safety Advisory... (RNA); Gulf Intracoastal Waterway, Inner Harbor Navigation Canal, Harvey Canal, Algiers Canal,...

  20. 77 FR 38630 - Open Internet Advisory Committee

    Science.gov (United States)

    2012-06-28

    ... and Society, Harvard University, is appointed chairperson of the Committee. Dr. David Clark, Senior... Laboratory, is appointed vice-chairperson. Members include: Harvey Anderson, Vice President of...

  1. 75 FR 68669 - Senior Executive Service; Departmental Performance Review Board

    Science.gov (United States)

    2010-11-08

    ... Network. David A. Lebryk, Commissioner, Financial Management Service. Wanda J. Rogers, Deputy Commissioner.... Harvey, Acting Deputy Assistant Secretary for Human Resources and Chief Human Capital Officer....

  2. Impact of enzyme- and ultrasound-assisted extraction methods on biological properties of red, brown, and green seaweeds from the central west coast of Portugal.

    Science.gov (United States)

    Rodrigues, Dina; Sousa, Sérgio; Silva, Aline; Amorim, Manuela; Pereira, Leonel; Rocha-Santos, Teresa A P; Gomes, Ana M P; Duarte, Armando C; Freitas, Ana Cristina

    2015-04-01

    Seaweeds are an excellent source of bioactive compounds, and therefore the use of sustainable and food compatible extraction methods such as enzyme-assisted (EAE) and ultrasound-assisted extraction were applied on Sargassum muticum, Osmundea pinnatifida, and Codium tomentosum. Extracts were evaluated for proximate characterization and biological properties. Higher extraction yields were observed for C. tomentosum EAE (48-62%; p polysaccharide (44 ± 8 mgNa2SO4 acid/glyoph extract) contents characterized O. pinnatifida extracts. A higher effect on hydroxyl-radical scavenging activity (35-50%) was observed for all extracts, whereas S. muticum Alcalase and C. tomentosum Cellulase extracts exhibited higher prebiotic activity than fructooligosaccharides. O. pinnatifida and C. tomentosum EAE showed inhibitory potential against α-glucosidase (38-49%).

  3. Laser Focus

    Science.gov (United States)

    Stuart, Reginald

    2011-01-01

    Hampton University President William Harvey's initial readings of proton therapy for cancer sparked his interest. Within a few months, Dr. Harvey was assigning widely respected Hampton nuclear physicist Dr. Cynthia Keppel to do more exploration. Today, the new $225 million Hampton University Proton Therapy Institute, one of eight therapy sites in…

  4. Making Hollow Men

    Science.gov (United States)

    Harvey, Charles W.

    2010-01-01

    In this essay Charles Harvey offers a worried reflection on the range, extent, depth, affects, and effects of the perpetual assessment of the person in (post)industrial nations in the contemporary world. Harvey begins his analysis by appealing to the work of Martin Heidegger, Michel Foucault, and Jean Baudrillard to provide an interpretive…

  5. The Wonderlic Personnel Test and Elementary Cognitive Tasks as Predictors of Religious Sectarianism, Scriptural Acceptance and Religious Questioning

    Science.gov (United States)

    Bertsch, Sharon; Pesta, Bryan J.

    2009-01-01

    Lynn, Harvey and Nyborg [Lynn, R., Harvey, J., & Nyborg, H. (in press). Average intelligence predicts atheism rates across 137 nations. "Doi:10.1016/j.intell.2008.03.004".] discovered that average intelligence (IQ) co-varies with national atheism rates. Extending this work, we investigated relationships among individual IQ scores,…

  6. Dynamics of Electronically Excited Species in Gaseous and Condensed Phase

    Science.gov (United States)

    1989-12-01

    Ph.D. Thesis, University of Minnesota, Minneapolis, MN, 1979 (unpublished). 41. D. G. Truhlar, N. M. Harvey, K. Onda , M. A. Brandt, in Algorithms and...Lawrence Berkeley Laboratory, Berkeley , CA, 1979), p. 220. 42. N. M. Harvey and D. G. Truhlar, Chem. Phys. Lett. 74, 252 (1980). 43. J. B. Delos and W. R

  7. The Wonderlic Personnel Test and Elementary Cognitive Tasks as Predictors of Religious Sectarianism, Scriptural Acceptance and Religious Questioning

    Science.gov (United States)

    Bertsch, Sharon; Pesta, Bryan J.

    2009-01-01

    Lynn, Harvey and Nyborg [Lynn, R., Harvey, J., & Nyborg, H. (in press). Average intelligence predicts atheism rates across 137 nations. "Doi:10.1016/j.intell.2008.03.004".] discovered that average intelligence (IQ) co-varies with national atheism rates. Extending this work, we investigated relationships among individual IQ scores,…

  8. Laser Focus

    Science.gov (United States)

    Stuart, Reginald

    2011-01-01

    Hampton University President William Harvey's initial readings of proton therapy for cancer sparked his interest. Within a few months, Dr. Harvey was assigning widely respected Hampton nuclear physicist Dr. Cynthia Keppel to do more exploration. Today, the new $225 million Hampton University Proton Therapy Institute, one of eight therapy sites in…

  9. Environmental Protection Agency

    Science.gov (United States)

    ... Harvey and Irma. Hurricane Response Hurricane Harvey update Hurricane Irma update Información en español Wildfires and Air Quality ... Data Hurricane Maria Update for 9/28/2017 Hurricane Irma Update for 9/27/2017 Hurricane Maria Update ...

  10. Disease: H00769 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available neurological disorder caused by defects in glycinergic neurotransmission. Hyperekplexia is characterized by neonatal hype...H00769 Hyperekplexia Hyperekplexia, also known as startle disease, is a paroxysmal ... PMID:18707791 (description, gene) Harvey RJ, Topf M, Harvey K, Rees MI The genetics of hyperekplexia: more

  11. 75 FR 55683 - Suspension of Community Eligibility

    Science.gov (United States)

    2010-09-14

    ..., contact David Stearrett, Mitigation Directorate, Federal Emergency Management Agency, 500 C Street SW..., ......do Do. County. Emerg; May 3, 1993, Reg; October 6, 2010, Susp. Kansas: Harvey County, 200585 October.... Newton, City of, Harvey 200133 September 13, ......do Do. County. 1974, Emerg; October 2, 1979,...

  12. 76 FR 40617 - Drawbridge Operation Regulation; Gulf Intracoastal Waterway, Near Hackberry, LA

    Science.gov (United States)

    2011-07-11

    ....8 west of Harvey Lock, near Hackberry, Calcasieu Parish, Louisiana. This deviation is necessary to... bridge on the SR 27 (Ellender Ferry) across the Gulf Intracoastal Waterway, mile 243.8, west of Harvey... CFR 117.35. Dated: June 20, 2011. David M. Frank, Bridge Administrator. BILLING CODE 9110-04-P...

  13. 77 FR 1405 - Drawbridge Operation Regulation; Gulf Intracoastal Waterway, LA

    Science.gov (United States)

    2012-01-10

    ... Harvey Locks, at Grand Lake, Cameron Parish, Louisiana. The deviation is necessary to allow for the safe..., call or email David Frank, Bridge Administration Branch; telephone (504) 671-2128, email David.m.frank... Lake Pontoon Bridge across the Gulf Intracoastal Waterway, mile 231.5 west of Harvey Lock (WHL),...

  14. 77 FR 75556 - Drawbridge Operation Regulation; Gulf Intracoastal Waterway, Louisiana

    Science.gov (United States)

    2012-12-21

    ... Boulevard bascule span drawbridge across the Harvey Canal Route, Gulf Intracoastal Waterway (GIWW), mile 2.8... temporary deviation from the operating schedule for the Bascule Span Bridge across the Harvey Canal Route....35. Dated: December 5, 2012. David M. Frank, Bridge Administrator. BILLING CODE 9110-04-P...

  15. 78 FR 14185 - Drawbridge Operation Regulation; Gulf Intracoastal Waterway, LA

    Science.gov (United States)

    2013-03-05

    ... drawbridge across the Harvey Canal Route, Gulf Intracoastal Waterway (GIWW), mile 2.8 at New Orleans... the operating schedule for the Bascule Span Bridge across the Harvey Canal Route, Intracoastal..., 2013. David M. Frank, Bridge Administrator. BILLING CODE 9110-04-P...

  16. 76 FR 70345 - Drawbridge Operation Regulation; Gulf Intracoastal Waterway, LA

    Science.gov (United States)

    2011-11-14

    ... of the Lapalco Boulevard bascule span drawbridge across the Harvey Canal Route, Gulf Intracoastal Waterway (GIWW), mile 2.8 at Harvey, Jefferson Parish, Louisiana. The deviation is necessary to allow for... INFORMATION CONTACT: If you have questions on this rule, call or email David Frank, Bridge...

  17. Thematic Repetition as Rhetorical Technique.

    Science.gov (United States)

    Allen, Jo

    1991-01-01

    Explores William Harvey's work, "On the Motion of the Heart and Blood in Animals." Highlights Harvey's fear of publication and his strategies for reducing resistance to his ideas. Underscores his use of circular references, metaphors, and organizational techniques that enhance and demonstrate his underlying thesis. (SG)

  18. Making Hollow Men

    Science.gov (United States)

    Harvey, Charles W.

    2010-01-01

    In this essay Charles Harvey offers a worried reflection on the range, extent, depth, affects, and effects of the perpetual assessment of the person in (post)industrial nations in the contemporary world. Harvey begins his analysis by appealing to the work of Martin Heidegger, Michel Foucault, and Jean Baudrillard to provide an interpretive…

  19. Reserve Component Personnel Issues: Questions and Answers

    Science.gov (United States)

    2013-07-12

    align reserve capabilities with active component requirements. See prepared statement of Vice Admiral John C. Harvey , Chief of Naval Personnel...before the Senate Armed Services Personnel Subcommittee, February 27, 2008, p. 5, http://armed-services.senate.gov/ statemnt/2008/February/ Harvey %2002-27...security and disaster relief missions in the aftermath of Hurricanes Katrina and Rita

  20. 78 FR 34293 - Regulated Navigation Area; Gulf Intracoastal Waterway, Inner Harbor Navigation Canal, New Orleans...

    Science.gov (United States)

    2013-06-07

    ... Navigation Canal (IHNC), the Harvey Canal, and the Algiers Canal. This action is necessary for the flood... Supplemental Notice of Proposed Rulemaking CPRA Coastal Protection Restoration Authority HSDRRS Hurricane Storm... Intracoastal Waterway, Inner Harbor Navigation Canal, Harvey Canal, Algiers Canal, New Orleans, LA'' in the...

  1. Turbidity, SOLAR RADIATION - ATMOSPHERIC and other data from MEIRING NAUDE, FRAAY R/K and FRANK HARVEY R/K in the Indian Ocean and South Atlantic Ocean from 1966-01-19 to 1979-03-23 (NCEI Accession 8200037)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set consists of Bathythermograph data extracted from a tape of physical oceanographic data submitted by the National Research Institute of Oceanography...

  2. Geography、Space Justice and Historic Materialism——Harvey David's Reform of the Geography of Marx%地理学、空间正义与历史地理唯物主义——论戴维·哈维对马克思主义的地理学改造

    Institute of Scientific and Technical Information of China (English)

    杨有庆

    2015-01-01

    对社会正义的追求,使哈维发现了传统实证地理学局限于学科内部的科学性追求而忽视了社会历史层面的不公正对地理的影响这一弊病,进而将地理学引人马克思主义,创造了坚持政治经济学批判的历史地理唯物主义.他从城市化与全球化两个层面展开对资本主义的空间批判.城市化的实质是资本城市化,也是资本主义资本积累与再生产的主要形式以及阶级斗争和资本积累之间内在矛盾的结果.全球化则是资本主义通过不断地空间征服和地理重组转嫁了自身的危机,掌握了越来越多的空间控制与支配.他对马克思主义的地理学改造使政治经济学批判在当代的社会政治、经济现实中获得了真实的地位,关于空间与资本主义关系的历史唯物主义解读对当下的文化研究影响巨大.

  3. 寻求政治解放的新可能性——论大卫·哈维空间正义理论%Search for New Possibilities of Political Emancipation On David Harvey's Theory of Space Justice

    Institute of Scientific and Technical Information of China (English)

    崔丽华

    2016-01-01

    在大卫·哈维看来,空间本身包含着政治属性.在此基础上,他强调社会差异,提出了不均衡地理发展所带来的人员、资金、信息等在全球规模上的高度流动,生产、技术、资本在全球空间的重新布局等等,这也深深地改变着今天世界政治的走向,从而产生了“新帝国主义”.他的终极目的是要建立一种没有掠夺、剥削的正义的资本主义.

  4. How to Develop Ecological Dialectics——By Analysing the Debating Between David Harvey and John Bellamy Foster%论发展生态辩证法何以可能——从戴维·哈维与约翰·贝拉米·福斯特的争论谈起

    Institute of Scientific and Technical Information of China (English)

    程倩春

    2016-01-01

    为彻底克服全球性生态危机,以哈维、福斯特为代表的生态马克思主义者对发展生态辩证法做出了极富启发意义的理论探索.本文试图通过厘清哈维与福斯特争论的焦点所在,探讨发展生态辩证法的主要矛盾,从而切实推进生态辩证法的发展,真正构建以生态文明为核心的社会价值观.

  5. 大卫·哈维新帝国主义资本批判思想探析——基于空间地理方法%The Analysis of David Harvey's Capital Critique to New Imperialism——On Space-Geographical Approach

    Institute of Scientific and Technical Information of China (English)

    戴卫华; 刘胜湘

    2015-01-01

    哈维追随马克思的资本批判路径,以空间地理方法为工具,基于资本逻辑与领土逻辑、资本危机与时空修复以及剥夺性积累与反抗的三个视角分析和批判新帝国主义的运行机制.哈维的新帝国主义批判理论沿袭了马克思主义政治经济学的批判范式,是对马克思资本批判之方法论资源和价值目标的继承;开启了帝国主义批判理论研究的新维度并创新了研究方法;与偏离马克思政治经济批判的各种资本主义后现代批判理论相比更具现实意义和理论说服力.

  6. Which Postmodernism?——David Harvey's History-Geography Materialist Explanation and Construction on Postmodernism%何种后现代——大卫·哈维对后现代的历史地理唯物主义解读与建构

    Institute of Scientific and Technical Information of China (English)

    董慧

    2010-01-01

    大卫·哈维的后现代主义理论是立足于马克思主义立场上展开,在空间化的历史唯物主义框架内,从政治经济批判入手,对后现代主义作为一种文化体验--新一轮"时空压缩"的逻辑前提、深层根源、独特表达及具体形成机制和过程详尽阐述.在他看来,后现代是一种文化的转移,其中贯穿着时空压缩的新一轮体验,最终造就了资本主义独特的历史地理学.

  7. 现代性的文学体验与大都市的空间改造——读戴维·哈维《巴黎,现代性之都》%Literary Experience of Modernity and Spatial Reconstruction of Metropolis——Reading David Harvey's Paris, Capital of Modernity

    Institute of Scientific and Technical Information of China (English)

    阎嘉

    2007-01-01

    现代性的文学体验与资本主义从19世纪中期以来对大都市的空间改造密切相关,这种都市空间的改造首先从巴黎开始,在巴尔扎克、福楼拜、左拉、波德莱尔等人的作品中被折射出来.大都市的空间改造体现了现代性的进程中以"创造性的破坏"和"时空压缩"为特征的物质化过程及其在情感体验上的结果.在文学上反映出来的陌生感、异化感、孤独感等,则可以被理解为"时空压缩"所带来的人们对时间和空间的体验中的迷惘、紧张乃至惊恐的内心体验.就此,哈维的《巴黎,现代性之都》为我们提供了有说服力的具体例证.

  8. 乌托邦与“希望的空间”——大卫·哈维的空间批判理论研究%Utopia and "Spaces of Hope"——Study on David Harvey's Spatial Critical Theory

    Institute of Scientific and Technical Information of China (English)

    李春敏

    2014-01-01

    乌托邦是哈维空间批判理论的重要维度,这一维度从对空间的现实审视导向了一种对于未来理想空间的探索.乌托邦与“空间的生产”之间有着辩证的多维联系,空间的生产中潜藏着乌托邦诉求,乌托邦的实践也要着眼于现实的空间构型.“空间形态的乌托邦”和“社会过程的乌托邦”代表了人类乌托邦探寻的两种不同向度,彰显了人类在乌托邦建构中对空间条件和历史过程的不同关注,“辩证的时空乌托邦”着眼于将时空维度融入乌托邦构想,是两种话语的批判性重构.立足于当代的历史地理条件,一种可能的乌托邦探寻应着眼于重建乌托邦批判、乌托邦想象和乌托邦理想的当代性.

  9. 21世纪社会民主和社会主义模式的政治经济学分析:继续探讨大卫·哈维提出的问题%Political Economy for 21st Century Models of Social Democracy and Socialism:Following up the Issues Raised by David Harvey

    Institute of Scientific and Technical Information of China (English)

    伊藤诚; 童珊

    2014-01-01

    大卫·哈维在其著作《资本之谜》中使用多因果方法综合马克思的各种危机理论来解释资本是如何必然导致资本主义经济的崩溃.本文在哈维的研究基础上首先使用基于劳动力短缺型危机理论分析了全球性通胀危机产生的原因、带来的后果及其对未来的影响;进而指出资本主义次贷危机、主权债务危机及全球性通胀危机,使我们不得不重新考虑共产主义、社会主义、无政府主义、社会民主主义等替代模式.在区分了21世纪社会民主和社会主义模式的异同之后,详细列举了21世纪社会民主和社会主义的四种有前景的战略部署:凯恩斯主义、绿色复苏、基本收入及本地货币.本文认为马克思主义政治经济学者可以从以上四个方面来重新思考21世纪激进社会主义战略模型的基础及其新发展的理论意义.

  10. The Pain of Otherness and Spacial Justice——The Care of ‘People' in David Harvey's Space Theory%他者之痛与空间正义——大卫·哈维空间理论的“人”之关照

    Institute of Scientific and Technical Information of China (English)

    吴红涛

    2014-01-01

    哈维从“不平衡地理”的议题出发,通过对空间区隔所导致的人之问题和资本主义生产空间中的“身体之困”的反思,分析了空间中广泛存在的他者之痛.进而,在哀悼传统乌托邦意义行将消失的基础上,哈维提出了“空间正义”的构想,倡导以一种辩证乌托邦的勇气,来正视空间中的“他者之痛”,以积极政治学来建构充满正义的地缘空间.

  11. 身体的困境及其解放可能——大卫·哈维的政治经济学批判与生态人类学阐释%Dilemma of Body and its Liberation——David Harvey's Critique of Political Economy and Ecological Anthropology

    Institute of Scientific and Technical Information of China (English)

    钱厚诚

    2014-01-01

    大卫·哈维把政治经济学批判置入身体研究当中,指明了身体的两面性:其一,作为“资本积累的策略”之身体,在全球化进程中陷入异化困境;其二,作为“阶级斗争的原初起点”之身体,在潜在的全球联合斗争过程中具有解放可能.并且,哈维从生态人类学层面阐释了人的身体当中所蕴藏着的解放潜力,从而为解放政治,以及为身体的解放寻找到一个源自于人本身的内在支撑.

  12. Reveal the Mysteries of Post-modemity: Review on David Harvey' s the Condition of Post-modernity%揭开后现代的神秘面纱——读大卫·哈维的《后现代的状况》

    Institute of Scientific and Technical Information of China (English)

    杨宇环

    2010-01-01

    本文跟随大卫·哈维的政治一经济批判思路对神秘而模糊的"后现代"时期进行了一次深入浅出的全面梳理和剖析,对一书的主要内容进行了粗线条的勾勒,重点阐述了"灵活积累"与"时空压缩"对资本主义社会由现代主义时期向后现代主义时期转型的重要影响,以及后现代主义在城市与建筑中的体现.

  13. Capital Accumulation and Logics of Power: A comparison on David Harvey's and Ellen Meiksins Wood's the New Imperialism%资本积累与权力逻辑——大卫·哈维与艾伦·伍德的新帝国主义观之比较

    Institute of Scientific and Technical Information of China (English)

    刘亚品

    2014-01-01

    20世纪90年代以来,国际左翼学者围绕“帝国”和“帝国主义”的争论一直很激烈,其中具代表性的有大卫·哈维的《新帝国主义》与艾伦·伍德的《资本的帝国》,他们都试图解释一种不同于旧帝国主义的“新帝国主义”的出现,都不同程度预示了资本在“新帝国主义”形成中不可替代的重要作用,并称其为“资本帝国主义”.但他们在分析资本积累无限扩张的逻辑起点上,以及在全球资本无限扩张的内在矛盾的解决路径上,却存在很大的不同,甚至是相反的.哈维认为,资本积累的无限扩张需要政治权力的无限扩张,资本积累产生的逻辑起点是权力的政治逻辑.伍德认为,资本可以独立于政治权力之外而存在,资本积累依赖资本自身的经济权力逻辑,并受到市场法则的制约和维护.二者的不同启示我们,重新审视政治和经济的关系,合理划分市场和政府的角色分工,在全球化时代,把握全球资本的注入和走向,实现国家经济的稳定发展.

  14. From Utopia to Dialectical Utopia in the Process of Rebuilding of Urban Spaces:The Meaning of 'Spaces of Hope' of David Harvey for China%城市空间重构:从"乌托邦"到"辩证乌托邦"——大卫·哈维《希望的空间》的中国化解读

    Institute of Scientific and Technical Information of China (English)

    王金岩; 吴殿廷

    2007-01-01

    通过对大卫·哈维《希望的空间》所包含的全球化背景下的地理空间不平衡思想的解读,认为中国城市空间存在着"辩证乌托邦"的机遇.中国城市在空间建构过程中,应该避免单一价值取向的"乌托邦",而应在多元要素组成的"生命之网"的基础上建构空间的"辩证乌托邦".进而探讨了这种"替代方案"的实现所需要政府角色和公共政策的转变,以及空间协调机制的整合,这是该书带给中国城市空间演进的最大意义.

  15. 瓦解“资本逻辑”视域中的国家概念——哈维对马克思国家理论的阐释%The Disintegration of the Concept of State in the View of Capital: David Harvey's Illumination of Marx's Theory of State

    Institute of Scientific and Technical Information of China (English)

    洪燕妮

    2015-01-01

    哈维立足于“生产方式”定位国家的本质,紧扣为资本增殖的逻辑来阐发国家观念,进而分析与批判“理性”、“权力”、“公共善”与现代国家的关系,从而达成对现代国家证成原则的真正“拆解”.在他看来,应该从作为“关系”或“过程”的视角理解国家,这一方法论原则对解构现代国家观念以及建构适合当下时代的马克思国家理论都极具价值.

  16. 山楂树全株的药用性能与应用

    Institute of Scientific and Technical Information of China (English)

    华盛; 李丽英; 华树芳

    2005-01-01

    人们通常称为山楂的原植物有3种,即蔷薇科植物山楂(Crataegus pinnatifida Bunge)、蔷薇科植物野山楂(Crataegus cuneata Sieb.et Zucc.)和蔷薇科植物山里红(Crataegus pinnatifuda Bunge).

  17. Environ: E00195 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available E00195 Crataegus fruit (JP16) Crataegi fructus Sanzashi Crude drug Quercetin [CPD:C...-Tartaric acid [CPD:C00898] Crataegus cuneata, Crataegus pinnatifida [TAX:510735], Crataegus... [TAX:23159] Same as: D06904 Rosaceae (rose family) Crataegus accessory fruit; Standards for non-pharmacopoeial crude drugs ...

  18. Extraction of Fucoxanthin from Raw Macroalgae excluding Drying and Cell Wall Disruption by Liquefied Dimethyl Ether

    Directory of Open Access Journals (Sweden)

    Hideki Kanda

    2014-04-01

    Full Text Available Macroalgae are one of potential sources for carotenoids, such as fucoxanthin, which are consumed by humans and animals. This carotenoid has been applied in both the pharmaceutical and food industries. In this study, extraction of fucoxanthin from wet brown seaweed Undaria pinnatifida (water content was 93.2% was carried out with a simple method using liquefied dimethyl ether (DME as an extractant in semi-continuous flow-type system. The extraction temperature and absolute pressure were 25 °C and 0.59 MPa, respectively. The liquefied DME was passed through the extractor that filled by U. pinnatifida at different time intervals. The time of experiment was only 43 min. The amount of fucoxanthin could approach to 390 μg/g dry of wet U. pinnatifida when the amount of DME used was 286 g. Compared with ethanol Soxhlet and supercritical CO2 extraction, which includes drying and cell disruption, the result was quite high. Thus, DME extraction process appears to be a good method for fucoxanthin recovery from U. pinnatifida with improved yields.

  19. Chemical composition of red, brown and green macroalgae from Buarcos bay in Central West Coast of Portugal.

    Science.gov (United States)

    Rodrigues, Dina; Freitas, Ana C; Pereira, Leonel; Rocha-Santos, Teresa A P; Vasconcelos, Marta W; Roriz, Mariana; Rodríguez-Alcalá, Luís M; Gomes, Ana M P; Duarte, Armando C

    2015-09-15

    Six representative edible seaweeds from the Central West Portuguese Coast, including the less studied Osmundea pinnatifida, were harvested from Buarcos bay, Portugal and their chemical characterization determined. Protein content, total sugar and fat contents ranged between 14.4% and 23.8%, 32.4% and 49.3% and 0.6-3.6%. Highest total phenolic content was observed in Codium tomentosum followed by Sargassum muticum and O. pinnatifida. Fatty acid (FA) composition covered the branched chain C13ai to C22:5 n3 with variable content in n6 and n3 FA; low n6:n3 ratios were observed in O. pinnatifida, Grateloupia turuturu and C. tomentosum. Some seaweed species may be seen as good sources of Ca, K, Mg and Fe, corroborating their good nutritional value. According to FTIR-ATR spectra, G. turuturu was associated with carrageenan seaweed producers whereas Gracilaria gracilis and O. pinnatifida were mostly agar producers. In the brown algae, S. muticum and Saccorhiza polyschides, alginates and fucoidans were the main polysaccharides found.

  20. Draft Genome Sequence of Lactobacillus plantarum MPL16, a Wakame-Utilizing Immunobiotic Strain Isolated from Swine Feces

    Science.gov (United States)

    Villena, Julio; Saavedra, Lucila; Suda, Yoshihito; Masumizu, Yuki; Albarracin, Leonardo; Clua, Patricia; Ikeda-Ohtsubo, Wakako

    2017-01-01

    ABSTRACT The genome of the immunomodulatory Lactobacillus plantarum MPL16, a strain able to ferment wakame (Undaria pinnatifida), is described here. The reads were assembled into contigs with a total size 3,278,495 bp. The genome information will be useful for further specific genetic studies of this strain that evaluate its immunomodulatory and biotechnological properties. PMID:28280008

  1. Pop / Lauri Tikerpe

    Index Scriptorium Estoniae

    Tikerpe, Lauri

    2006-01-01

    Heliplaatidest: TM Juke "Forward", Miljoonasade "Kasvukipuja 20 vuotta", JJ Cale & Eric Clapton "The Road to Escondido", Xiu Xiu "The Air Force", Leo Abrahams "Scene Memory", Michael Brook "RockPaperScissors", PJ Harvey "The Peel Sessions 1991-2004"

  2. At R209

    CERN Multimedia

    1977-01-01

    Large concrete wall, shielding the ouside muon chambers from background particles coming from the ISR tunnel. One sees at work Lars Leistam, a crane driver, Harvey Newman, Min Chen, Ingrid ?, ??. Gunter Feilhauer is on top of the magnet.

  3. Forty Years of Salmonella enterica Dublin in People

    Centers for Disease Control (CDC) Podcasts

    2017-10-05

    Dr. Reid Harvey, a CDC epidemiologist, discusses Salmonella enterica Dublin in People.  Created: 10/5/2017 by National Center for Emerging and Zoonotic Infectious Diseases (NCEZID).   Date Released: 10/5/2017.

  4. Reproducible in vitro regeneration system for purifying sugarcane ...

    African Journals Online (AJOL)

    Tansgenic Lab

    2012-05-24

    May 24, 2012 ... Full Length Research Paper. Reproducible in ... regeneration was varied from basal to top sections. Nevertheless ... 2005). The application of biotechnology to sugarcane is comparatively ..... Damon RA, Harvey WR (1987).

  5. the mauritius stock exchange: sectoral analysis, risk and return

    African Journals Online (AJOL)

    cistvr

    Companies listed on the Mauritius Stock Exchange are classified into seven sectors of .... was also opened to foreign investors, following the suspension of the Foreign ...... HARVEY, C. (1995), The Risk Exposure of Emerging Equity Markets.

  6. American Society of Human Genetics

    Science.gov (United States)

    ... Public Policy Fellow Nikki Meadows September 15, 2017 Hurricane Irma and ASHG 2017 in Orlando September 13, 2017 AJHG Virtual Special Issue 2017: Genomics in the Clinic September 12, ... Affected by Hurricane Harvey August 28, 2017 New CME Program: Prenatal ...

  7. Plaat

    Index Scriptorium Estoniae

    2007-01-01

    Heliplaadid kauplustest Lasering: Diskreetse Mango Trio "Prigadi-pragadi", P J Harvey "The Peel Sessions 1991-2004", Tom Waits "Orphans" (3 CD-d), Zahir "Green means go", Yusuf "An Another Cup", Norah Jones "Not Too Late"

  8. Plaat

    Index Scriptorium Estoniae

    2007-01-01

    Heliplaadid kauplustest Lasering: Diskreetse Mango Trio "Prigadi-pragadi", P J Harvey "The Peel Sessions 1991-2004", Tom Waits "Orphans" (3 CD-d), Zahir "Green means go", Yusuf "An Another Cup", Norah Jones "Not Too Late"

  9. McLean's second variation formula revisited

    Science.gov (United States)

    Lê, Hông Vân; Vanžura, Jiří

    2017-03-01

    We revisit McLean's second variation formulas for calibrated submanifolds in exceptional geometries, and correct his formulas concerning associative submanifolds and Cayley submanifolds, using a unified treatment based on the (relative) calibration method and Harvey-Lawson's identities.

  10. 78 FR 28875 - Changes in Flood Hazard Determinations

    Science.gov (United States)

    2013-05-16

    ... No.: B- City of Prescott The Honorable Harvey C. Engineering March 11, 2013 040121 1286). Valley (12...- Unincorporated areas The Honorable David Rice, Monroe County March 25, 2013 125129 1294). of Monroe County...

  11. 75 FR 29208 - Changes in Flood Elevation Determinations

    Science.gov (United States)

    2010-05-25

    ... Unincorporated areas December 3, 2009, The Honorable David April 9, 2010 080124 of Montrose County December 10.... Mississippi: Hinds City of Jackson (09- January 15, 2010, The Honorable Harvey December 31, 2009 280072...

  12. Ultrasound

    Science.gov (United States)

    ... Saunders; 2014:chap 66. Cosgrove DO, Eckersley RJ, Harvey CJ, Lim A. Ultrasound. In: Adam A, Dixon AK, Gillard ... Northside Radiology Associates, Atlanta, GA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the ...

  13. Breast ultrasound

    Science.gov (United States)

    ... 6th ed. Philadelphia, PA: Elsevier; 2016:chap 30. Harvey JA, Mahoney MC, Newell MS, et al. ACR ... Mason Medical Center, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the ...

  14. 75 FR 52006 - Granting of Request for Early Termination of the Waiting Period Under the Premerger Notification...

    Science.gov (United States)

    2010-08-24

    ..., Inc. G Cougar Biotechnology, Inc. 20090515 G OCM/GFI Power Opportunities Fund II, L.P. G Robert David.... 20090528 G Alternative Asset Management Acquisition Corp. G Harvey M. Yellen. G Great American Group,...

  15. Kui Thatcher kiidab ja Pinochet teeb pai / Erik Terk

    Index Scriptorium Estoniae

    Terk, Erik

    2006-01-01

    Thatcheri ja Reagani nimedega seostatav neoliberaalne revolutsioon on saanud piisavalt vanaks, et kujundada pilt, mis toimus ja kuhu see meid viib. See ongi uue neoliberalismiraamatu David Harvey. A Brief History of Neoliberalism aineks

  16. 76 FR 44276 - Changes in Flood Elevation Determinations

    Science.gov (United States)

    2011-07-25

    ... Honorable Kathy August 5, 2011 100066 0744P). April 7, 2011; The Harvey, Mayor, Town of Middletown Odessa, P... Santa Fe (10- March 3, 2011; March The Honorable David Coss, February 24, 2011 350070 06-2026P)....

  17. Epilepsy - children

    Science.gov (United States)

    ... Philadelphia, PA: Elsevier; 2012:chap 50. Freeman J, Harvey S. Seizures and epilepsies. In: South M, Ashwal S, Isaacs ... School of Medicine, Seattle, WA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the ...

  18. 75 FR 59327 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2010-09-27

    .... Albrecht Elijah A. Allen, Jr. David W. Brown Monty G. Calderon Awilda S. Colon David M. Hagadorn Zane G. Harvey, Jr. Jeffrey M. Keyser Donnie A. Kildow Daniel A. McNabb David G. Meyers Thomas L. Oglesby...

  19. Pop / Lauri Tikerpe

    Index Scriptorium Estoniae

    Tikerpe, Lauri

    2006-01-01

    Heliplaatidest: TM Juke "Forward", Miljoonasade "Kasvukipuja 20 vuotta", JJ Cale & Eric Clapton "The Road to Escondido", Xiu Xiu "The Air Force", Leo Abrahams "Scene Memory", Michael Brook "RockPaperScissors", PJ Harvey "The Peel Sessions 1991-2004"

  20. 76 FR 30099 - Foreign-Trade Zone 161-Sedgwick County, KS; Application for Reorganization/Expansion Under...

    Science.gov (United States)

    2011-05-24

    ... Street North, Wichita. The grantee's proposed service area under the ASF would be Butler, Harvey, Mc... Assembly Facility, 1000 Commerce Street, Hutchinson (Reno County). Because the ASF only pertains...

  1. Genetics Home Reference: hereditary hyperekplexia

    Science.gov (United States)

    ... Owen MJ, Tijssen MA, van den Maagdenberg AM, Smart TG, Supplisson S, Harvey RJ. Mutations in the gene ... of the glycine receptor alpha1 subunit affect cell surface integration and stability. J Neurochem. 2009 Nov;111( ...

  2. Kui Thatcher kiidab ja Pinochet teeb pai / Erik Terk

    Index Scriptorium Estoniae

    Terk, Erik

    2006-01-01

    Thatcheri ja Reagani nimedega seostatav neoliberaalne revolutsioon on saanud piisavalt vanaks, et kujundada pilt, mis toimus ja kuhu see meid viib. See ongi uue neoliberalismiraamatu David Harvey. A Brief History of Neoliberalism aineks

  3. Hemingway oli KGB, filmistaar Errol Flynn natside agent? / Tõnis Erilaid

    Index Scriptorium Estoniae

    Erilaid, Tõnis, 1943-

    2009-01-01

    John Earl Haynes, Harvey Klehr ja Alexander Vassiliev väidavad oma raamatus "Spies : The Rise and Fall of the KGB in America", et Ernest Hemingway oli 1940ndail aastail KGB ning Errol Flynn 1930ndatel aastatel natside agent

  4. Hemingway oli KGB, filmistaar Errol Flynn natside agent? / Tõnis Erilaid

    Index Scriptorium Estoniae

    Erilaid, Tõnis, 1943-

    2009-01-01

    John Earl Haynes, Harvey Klehr ja Alexander Vassiliev väidavad oma raamatus "Spies : The Rise and Fall of the KGB in America", et Ernest Hemingway oli 1940ndail aastail KGB ning Errol Flynn 1930ndatel aastatel natside agent

  5. Comparison of the acute effects of Tulbaghia violacea William Henry ...

    African Journals Online (AJOL)

    Harvey (Alliaceae) on blood pressure (BP) and heart rate in ageing normotensive Wistar Kyoto rats ... measured via a pressure transducer connecting the femoral artery and Powerlab equipment. ..... ambulatory blood pressure monitoring.

  6. Consumer Product Safety Commission

    Science.gov (United States)

    ... Businesses Home Home Safe Steps at Home After Hurricane Harvey Statement from CPSC Acting Chairman Ann Marie Buerkle Surviving the Aftermath of a Hurricane - Portable Generator Safety (pdf) 4 Deadly Hazards to ...

  7. Foundations in the Law: Classic Cases in Medical Ethics

    Science.gov (United States)

    2007-01-01

    WILLIAM PEDRO ) Jane P. Gordon, Clerk GRIGGS, EMMITT GRIMES, PERCY GRIMES, ) WALTER HARVEY, ERNEST HENDON, LOUIE ) By M.T. B. HENDON, ISIAH JACKSON ...Archie Foster, Lee Foster, Charlie Griggs, William Pedro Griggs, Emmitt Grimes, Percy Grimes, Walter Harvey, Ernest Hendon, Louie C. Hendon, Isiah Jackson ...135 Mr. Justice Jackson delivered the opinion of the Court. A common issue arising under the Federal Tort Claims Act, as to which Courts of Appeal are

  8. United States Zone Constabulary: An Analysis of Manning Issues and Their Impact on Operations

    Science.gov (United States)

    2006-06-16

    Theodore W. Bauer, Elizabeth S. Lytle, Constance Gavares, Harvey L. Horwich, Joanne M. Lucas, G. D. Hecht , Margaret L. Geis, and George J. Gray. The Fourth...Bloomington, IN: Indiana University Press, 1975, 214. Davidson, Eugene . The Death and Life of Germany. New York: Knopf, 1959. Davis, Franklin M., Jr. Come...Gavares, Harvey L. Horwich, Joanne M. Lucas, G. D. Hecht , Margaret L. Geis, and George J. Gray. The Fourth Year of the Occupation, Vol. 5 The Major

  9. Building a Better Model: A Comprehensive Breast Cancer Risk Model Incorporating Breast Density to Stratify Risk and Improve Application of Resources

    Science.gov (United States)

    2013-10-01

    ANTIPERSPIRANT USE 5 BIRTH CONTROL PILL USE 6 BREAST BIOPSY WITH OR WITHOUT ATYPIA/HIGH RISK LESION 7 BREAST SIZE 8 BREAST TISSUE DENSITY 9...comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS...match them to controls (Harvey/Knaus). Validate and refine automated breast density software (Yaffe/Harvey). Build and validate the initial

  10. Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo

    OpenAIRE

    Ramaswamy, Lalitha; Velraja, Supriya; Harvey, Phil; Escalante, Guillermo; Alencar, Michelle; Haddock, Bryan; Zawieja, Bogna; Trussardi Fayh, Ana Paula; Okano, Alexandre Hideki; de Jesus Ferreira, Amanda Maria; Jäger, Ralf; Purpura, Martin; Harris, Roger C.; Lavanger, Kiley A.; Krause, Molly M.

    2016-01-01

    Table of contents P1 Impact of antioxidant-enriched nutrient bar supplementation on the serum antioxidant markers and physical fitness components of track and field athletes Lalitha Ramaswamy, Supriya Velraja P2 The effects of phosphatidic acid supplementation on fitness levels in resistance trained women Guillermo Escalante, Phil Harvey, Michelle Alencar, Bryan Haddock P3 The effects of phosphatidic acid supplementation on cardiovascular risk factors in resistance trained men Phil Harvey, Gu...

  11. Pharmacological and Behavioral Enhancement of Neuroplasticity in the MPTP Lesioned Mouse and Nonhuman Primate

    Science.gov (United States)

    2007-05-01

    baboons. Neurosci 53, 169-178. Harvey, D. C., Lacan , G., Melega, W. P. (2000a). Regional heterogeneity of dopaminerigc deficits in vervet monkey...striatum and substantia nigra after methamphetamine exposure. Experimental Brain Research 133, 349-358. Harvey, D. C., Lacan , G., Tanious, S. P., Melega... Lacan , G., Huang, S.-C., Phelps, M. E. (1997). Recovery of striatal dopamine function after acute amphetamine- and methamphetamine-induced

  12. 33 CFR 89.27 - Waters upon which Inland Rule 24(i) applies.

    Science.gov (United States)

    2010-07-01

    ... West of Harvey Locks (WHL) to the Michoud Canal at Mile 18 EHL. (6) The Calcasieu River from the Calcasieu Lock at Mile 238.6 WHL to the Ellender Lift Bridge at Mile 243.6 WHL. (7) The Sabine Neches Canal... 284.6 East of Harvey Locks (EHL) to the DuPont Fixed Bridge at Mile 295.4 EHL. (2) Pensacola...

  13. Sharing Power? Prospects for a U.S. Concert-Balance Strategy

    Science.gov (United States)

    2013-04-01

    Benjamin Schwarz recently, and Eugene Gholz, Daryl G. Press, and Harvey M. Sapolsky earlier, have suggested an outline of the “hemispheric pull- back...intention to project its interests region- ally through military or paramilitary forces has made Iran its own worst enemy. Iran’s neighbours are choos ... Eugene Gholz, Daryl G. Press, and Harvey M. Sapolsky, “Come Home America: The Strategy of Restraint in the Face of Temptation,” International

  14. LHCb velo detector

    CERN Multimedia

    Patrice Loïez

    2001-01-01

    Photo 01 : L. to r.: D. Malinon, Summer Student, J. Libby, Fellow, J. Harvey, Head of CERN LHCb group, D. Schlatter, Head of the EP Division in front of the LHCb velo detector test beam (on the right). Photo 02 : L. to r.: J. Harvey, D. Schlatter, W. Riegler (staff), H.J. Hilke, LHCb Technical Coordinator in front of the muon chamber test beam

  15. A Cost Benefit Analysis of Security at the Naval Postgraduate School

    Science.gov (United States)

    2003-12-01

    analysis. A particularly clear statement of the principles can be found in Dr. Harvey S. Rosen’s textbook, Public Finance . Dr. Rosen earned his...Department of Economics since 1974. Dr. Rosen’s main field of research is public finance and he is currently on hiatus from Princeton at the Council of...bio.html> [30 November 2003]. 16 Harvey S. Rosen, Public Finance , 6th edition, (McGraw-Hill/Irwin, 2001), 220. 11 jobs, the environment, public

  16. Behavioral and Physiological Response of Baleen Whales to Ships and Ship Noise

    Science.gov (United States)

    2014-09-30

    943-7026 email: calambokidis@cascadiaresearch.org Collaborators: SW Fisheries Science Center (Kellar), Moss Landing Marine Labs ( Harvey and...occurred in FY2014. Work completed to date includes: 1. Continued collaboration with Moss Landing Marine Laboratories (Dr. Jim Harvey and graduate...could conduct a recovery of the tag (made more complicated by the location and the passage of a hurricane hitting Baja when it was released. The

  17. 山楂的化学成分及药理研究进展

    Institute of Scientific and Technical Information of China (English)

    罗玉梅; 王贺振

    2004-01-01

    山楂为蔷薇科(Rosaceae)落叶灌木或小乔木山楂Crataegus pinnatifida Bunge、山里红Grataegus pinnatifida Bunge var.major N.E.Br.及野山楂Crataegus cuneata Sieb et Zucc.的干燥成熟果实。前两种习称“北山楂”,后一种习称“南山楂”。全国各地均有栽培·为药食同源植物。山楂性酸、甘、味温.归脾、胃、肝经.具有消食化积、活血化瘀的功效,临床用于食滞不化及产后瘀阻

  18. RP-HPLC法测定山楂叶中牡荆素鼠李糖苷及牡荆素葡萄糖苷的含量

    Institute of Scientific and Technical Information of China (English)

    龚青; 张叶萍; 祝明

    2005-01-01

    山楂叶为蔷薇科植物山里红Crataegus pinnatifida Bunge var.major N.E.Br.或山楂C.pinnatifida Bunge的干燥叶,具有调血脂、降血压的功效。山楂叶主要含有黄酮类化合物(槲皮素、金丝桃苷、牡荆素、牡荆素葡萄糖苷、牡荆素鼠李糖苷)、有机酸类化合物及一些微量元素。其中黄酮类化合物具有调血脂、防止动脉硬化、增加冠脉流量、抗心肌缺氧及心律失常等活性。

  19. Preliminary Investigations of Biofouling of Ships’ Hulls: Non-Indigenous Species Investigations in the Columbia River

    Science.gov (United States)

    2006-04-01

    hulls of two vessels.................................37 Figure 17. MDS plots of benthic (A) and planktonic (B) fauna in the LCR based on presence...to eradicate the threat posed by the invasive seaweed Undaria pinnatifida (Wotton, O’Brien, Stuart & Fergus, 2004). 11 1.5 The Lower Columbia... plankton and salmonid distributions (Morgan, DeRobertis & Zabel, 2005; De Robertis, Morgan, Schabetsberger, Zabel, Brodeur, Emmett, Knight

  20. Možnosti pěstování některých méně pěstovaných ovocných druhů v ČR

    OpenAIRE

    Rózsová, Ivana

    2015-01-01

    This bachelor thesis is dedicated to lesser cultivated fruit species (Crataegus laevigata (Poir. in Lam.) DC, Crataegus pinnatifida Bunge, Cydonia oblonga Mill., Mespilus germanica L. a Sorbus domestica L.), their specification from a taxonomic and morphological point of view, and deals with options of growing these species on area of Czech Republic. It also describes some possibilities of processing the fruit (processing of medlar was only described theoretically) and compares the success of...

  1. Complete Plastid Genome of the Brown Alga Costaria costata (Laminariales, Phaeophyceae.

    Directory of Open Access Journals (Sweden)

    Lei Zhang

    Full Text Available Costaria costata is a commercially and industrially important brown alga. In this study, we used next-generation sequencing to determine the complete plastid genome of C. costata. The genome consists of a 129,947 bp circular DNA molecule with an A+T content of 69.13% encoding a standard set of six ribosomal RNA genes, 27 transfer RNA genes, and 137 protein-coding genes with two conserved open reading frames (ORFs. The overall genome structure of C. costata is nearly the same as those of Saccharina japonica and Undaria pinnatifida. The plastid genomes of these three algal species retain a strong conservation of the GTG start codon while infrequently using TGA as a stop codon. In this regard, they differ substantially from the plastid genomes of Ectocarpus siliculosus and Fucus vesiculosus. Analysis of the nucleic acid substitution rates of the Laminariales plastid genes revealed that the petF gene has the highest substitution rate and the petN gene contains no substitution over its complete length. The variation in plastid genes between C. costata and S. japonica is lower than that between C. costata and U. pinnatifida as well as that between U. pinnatifida and S. japonica. Phylogenetic analyses demonstrated that C. costata and U. pinnatifida have a closer genetic relationship. We also identified two gene length mutations caused by the insertion or deletion of repeated sequences, which suggest a mechanism of gene length mutation that may be one of the key explanations for the genetic variation in plastid genomes.

  2. Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters

    OpenAIRE

    Yuguang Lin; Vermeer, Mario A.; Trautwein, Elke A.

    2011-01-01

    Hawthorn (Crataegus pinnatifida) is an edible fruit used in traditional Chinese medicine to lower plasma lipids. This study explored lipid-lowering compounds and underlying mechanisms of action of hawthorn. Hawthorn powder extracts inhibited acylCoA:cholesterol acyltransferase (ACAT) activity in Caco-2 cells. The inhibitory activity was positively associated with triterpenic acid (i.e., oleanolic acid (OA) and ursolic acid (UA)) contents in the extracts. Cholesterol lowering effects of hawtho...

  3. Essential oil of one of the Iranian skullcaps.

    Science.gov (United States)

    Ghannadi, Alireza; Mehregan, Iraj

    2003-01-01

    The hydro-distilled essential oil from dried aerial parts of one of widespread Iranian skullcaps, Scutellaria pinnatifida A. Hamilt. sap. alpina (Bornm.) Rech. grown in Khorassan province was analyzed by GC and GC/MS. Thirty components were characterized ing 93.8% of the total components detected. The major components of the oil were germacrene-D (39.7%) and beta-caryophyllene (15.0%).

  4. Fucoidan from Macrocystis pyrifera Has Powerful Immune-Modulatory Effects Compared to Three Other Fucoidans

    Directory of Open Access Journals (Sweden)

    Wei Zhang

    2015-02-01

    Full Text Available Fucoidan, a sulfated polysaccharide purified from brown algae, has a variety of immune-modulation effects, such as promoting activation of dendritic cells (DCs, natural killer (NK cells and T cells, and enhancing anti-viral and anti-tumor responses. However, the immune-modulatory effect of fucoidan from different seaweed extracts has not been thoroughly analyzed and compared. We analyzed fucoidans obtained from Ascophyllum nodosum (A. nodosum, Macrocystis pyrifera (M. pyrifera, Undaria pinnatifida (U. pinnatifida and Fucus vesiculosus (F. vesiculosus for their effect on the apoptosis of human neutrophils, activation of mouse NK cells, maturation of spleen DCs, proliferation and activation of T cells, and the adjuvant effect in vivo. Fucoidans from M. pyrifera and U. pinnatifida strongly delayed human neutrophil apoptosis at low concentration, whereas fucoidans from A. nodosum and F. vesiculosus delayed human neutrophil apoptosis at higher concentration. Moreover, fucoidan from M. pyrifera promoted NK cell activation and cytotoxic activity against YAC-1 cells. In addition, M. pyrifera fucoidan induced the strongest activation of spleen DCs and T cells and ovalbumin (OVA specific immune responses compared to other fucoidans. These data suggest that fucoidan from M. pyrifera can be potentially useful as a therapeutic agent for infectious diseases, cancer and an effective adjuvant for vaccine.

  5. Acids, sugars, and sugar alcohols in Chinese hawthorn (Crataegus spp.) fruits.

    Science.gov (United States)

    Liu, Pengzhan; Kallio, Heikki; Lü, Deguo; Zhou, Chuansheng; Ou, Shiyi; Yang, Baoru

    2010-01-27

    Acids, sugars, and sugar alcohols in the fruits of 22 cultivars/origins of three species of hawthorn (Crataegus spp.) were analyzed by gas chromatography and mass spectrometry. Citric acid (2.0-8.4 g/100 g dry mass [DM]), quinic acid (0.5-5.6 g/100 g DM), malic acid (0.3-1.1 g/100 g DM), fructose (5.5-18.4 g/100 g DM), glucose (5.3-16.6 g/100 g DM), sorbitol (3.0-15.7 g/100 g DM), and myo-inositol (0.1-0.3 g/100 g DM) were found in all the samples. Sucrose was present only in C. scabrifolia and three cultivars of C. pinnatifida var. major. C. scabrifolia differed from other species by its high content of quinic acid. The cultivars of C. pinnatifida var. major and C. brettschneideri had a higher content of total sugars and a higher sugar/acid ratio than the natural origins of C. pinnatifida and C. scabrifolia (P hawthorn samples analyzed fell into two groups rich in sugars and acids respectively. This is the first report of the profiles of sugars and sugar alcohols and the occurrence of quinic acid in hawthorn fruits.

  6. Arsenic Species in Edible Seaweeds Using In Vitro Biomimetic Digestion Determined by High-Performance Liquid Chromatography Inductively Coupled Plasma Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Yan-Fang Zhao

    2014-01-01

    Full Text Available Arsenite [As (III], arsenate [As (V], methylarsonate (MMA, and dimethylarsinate (DMA in five edible seaweeds (the brown algae Laminaria japonica, red algae Porphyra yezoensis, brown algae Undaria pinnatifida, brown algae Hizikia fusiformis, and green algae Enteromorpha prolifera were analyzed using in vitro digestion method determined by high-performance liquid chromatography inductively coupled plasma mass spectrometry. The results showed that DMA was found in the water extracts of all samples; As (III were detected in L. japonica and U. pinnatifida and about 23.0 and 0.15 mg/kg of As (V were found in H. fusiformis and E. prolifera respectively. However, after the gastrointestinal digestion, As (V was not detected in any of the five seaweeds. About 0.19 and 1.47 mg/kg of As (III was detected in the gastric extracts of L. japonica and H. fusiformis, respectively, and about 0.31 and 0.10 mg/kg of As (III were extracted from the intestinal extracts of Porphyra yezoensis and U. pinnatifida, respectively. The present results successfully reveal the differences of As species and levels in the water and biomimetic extracts of five edible seaweeds. The risk assessment of the inorganic arsenic in the five edible seaweeds based on present data showed almost no hazards to human health.

  7. Chemically-mediated interactions between macroalgae Dictyota spp. and multiple life-history stages of the coral Porites astreoides

    Science.gov (United States)

    Paul, Valerie J.; Kuffner, Ilsa B.; Walters, Linda J.; Ritson-Williams, Raphael; Beach, Kevin S.; Becerro, Mikel A.

    2011-01-01

    Competition between corals and macroalgae is often assumed to occur on reefs, especially those that have undergone shifts from coral to algal dominance; however, data examining these competitive interactions, especially during the early life-history stages of corals, are scarce. We conducted a series of field and outdoor seawater-table experiments to test the hypothesis that allelopathy (chemical inhibition) mediates interactions between 2 common brown macroalgae, Dictyota pulchella and D. pinnatifida, and the coral Porites astreoides at different life-history stages of the coral. D. pinnatifida significantly reduced larval survival and larval recruitment. The extracts of both D. pinnatifida and D. pulchella significantly reduced larval survival, and the extract of D. pulchella also negatively influenced larval recruitment. There was no measurable effect of the crude extracts from Dictyota spp. on the photophysiology of adult corals. Our results provide evidence that these Dictyota species chemically compete with P. astreoides by negatively affecting larval settlement and recruitment as well as the survival of larvae and new recruits. Macroalgae may perpetuate their dominance on degraded reefs by chemically inhibiting the process of coral recruitment.

  8. Chemically mediated interactions between macroalgae Dictyota spp. and multiple life-history stages of the coral Porites astreoides

    Science.gov (United States)

    Paul, V.J.; Kuffner, I.B.; Walters, L.J.; Ritson-Williams, R.; Beach, K.S.; Becerro, M.A.

    2011-01-01

    Competition between corals and macroalgae is often assumed to occur on reefs, especially those that have undergone shifts from coral to algal dominance; however, data examining these competitive interactions, especially during the early life-history stages of corals, are scarce. We conducted a series of field and outdoor seawater-table experiments to test the hypothesis that allelopathy (chemical inhibition) mediates interactions between 2 common brown macroalgae, Dictyota pulchella and D. pinnatifida, and the coral Porites astreoides at different life-history stages of the coral. D. pinnatifida significantly reduced larval survival and larval recruitment. The extracts of both D. pinnatifida and D. pulchella significantly reduced larval survival, and the extract of D. pulchella also negatively influenced larval recruitment. There was no measurable effect of the crude extracts from Dictyota spp. on the photophysiology of adult corals. Our results provide evidence that these Dictyota species chemically compete with P. astreoides by negatively affecting larval settlement and recruitment as well as the survival of larvae and new recruits. Macroalgae may perpetuate their dominance on degraded reefs by chemically inhibiting the process of coral recruitment. ?? 2011 Inter-Research.

  9. Sperm whale clicks: Directionality and source level revisited

    DEFF Research Database (Denmark)

    Møhl, Bertel; Wahlberg, Magnus; Madsen, Peter T.;

    2000-01-01

    In sperm whales ~Physeter catodon L. 1758! the nose is vastly hypertrophied, accounting for about one-third of the length or weight of an adult male. Norris and Harvey @in Animal Orientation and Navigation, NASA SP-262 ~1972!, pp. 397–417# ascribed a sound-generating function to this organ complex....... A sound generator weighing upward of 10 tons and with a cross-section of 1 m is expected to generate high-intensity, directional sounds. This prediction from the Norris and Harvey theory is not supported by published data for sperm whale clicks ~source levels of 180 dB re 1 mPa and little, if any....... This implicates sonar as a possible function of the clicks. Thus, previously published properties of sperm whale clicks underestimate the capabilities of the sound generator and therefore cannot falsify the Norris and Harvey theory....

  10. Linear systems formulation of scattering theory for rough surfaces with arbitrary incident and scattering angles.

    Science.gov (United States)

    Krywonos, Andrey; Harvey, James E; Choi, Narak

    2011-06-01

    Scattering effects from microtopographic surface roughness are merely nonparaxial diffraction phenomena resulting from random phase variations in the reflected or transmitted wavefront. Rayleigh-Rice, Beckmann-Kirchhoff. or Harvey-Shack surface scatter theories are commonly used to predict surface scatter effects. Smooth-surface and/or paraxial approximations have severely limited the range of applicability of each of the above theoretical treatments. A recent linear systems formulation of nonparaxial scalar diffraction theory applied to surface scatter phenomena resulted first in an empirically modified Beckmann-Kirchhoff surface scatter model, then a generalized Harvey-Shack theory that produces accurate results for rougher surfaces than the Rayleigh-Rice theory and for larger incident and scattered angles than the classical Beckmann-Kirchhoff and the original Harvey-Shack theories. These new developments simplify the analysis and understanding of nonintuitive scattering behavior from rough surfaces illuminated at arbitrary incident angles.

  11. 合宝(Hubbell)综合布线在中国

    Institute of Scientific and Technical Information of China (English)

    洪剑青

    2000-01-01

    十九世纪末,合宝集团创始人Harvey Hubbell发明了世界上首个电灯开关、电源插头及插座,对改善人类的生活素质做出了重要贡献。即此,1888年Harvey Hubbell在美国康州始创了合宝。经过一个多世纪的发展,合宝已发展成为一家全球知名的跨国企业一美国合宝集团。

  12. 亲爱的忧郁PJ Harvey之《White Chalk》

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ 听到"Dear Darkness"时,如往常一样拉扯并且战栗的女声却分明地陌生起来.许多期待着她的人都能顿时明白,这是一个新的PJ Harvey.她冷得像冰凉潮湿的雨季,而她的音乐给人的药效,开始倾向于一种致命和快速.中庸点讲,这样镇静冷漠的PJ Harvey,可以持续更久.

  13. Presencia simultánea de las fases tetraspororangial y carposporangial sobre el mismo talo en Polysiphonia scopulorum var. villum (Rhodomelaceae, Rhodophyta Mixed phases tetrasporangial and carposporangial on the same thallus in Polysiphonia scopulorum var. villum (Rhodomelaceae, Rhodophyta

    Directory of Open Access Journals (Sweden)

    Raúl Aguilar-Rosas

    2010-04-01

    Full Text Available Se describe por primera vez la presencia simultánea de las fases tetrasporangial (tetrasporangios y carposporangial (cistocarpos sobre el mismo talo en Polysiphonia scopulorum W.H. Harvey var. villum (J. Agardh Hollenberg. El material fue recolectado en la zona intermareal rocosa de Playa Saldamando, Baja California, México, durante octubre de 2004.Mixed tetrasporangial (tetrasporangia and carposporangial (cistocarps phases on the same thallus in Polysiphonia scopulorum W.H. Harvey var. villum (J. Agardh Hollenberg (Rhodomelaceae, Rhodophyta are described for the first time. The material was collected on Octuber, 2004 in the intertidal zone in Playa Saldamando, Baja California, Mexico.

  14. Isobaric Inert Gas Counterdiffusion,

    Science.gov (United States)

    1982-11-01

    19104 Cdr. Claude A. Harvey, MC,USN Dr. John A. Quinn Pearl Harbor, Hawaii School of Chemical Engineering FPO San Francisco, California 96601...supersaturation: A possible explanation for inert gas "urticaria𔃽 and "vertigo." Phys. Med. Biol. 18:356-364. Groom, A.C., R. Morin , and L.E. Farhi. 1967...done at New London with humans, was itching.noticed in that case? A. Yes, Claude Harvey noticed itching. I think it was at the 100 fsw. They did not

  15. Scalability in Production System Programs

    Science.gov (United States)

    1994-01-01

    Engineering Review , 8(2):121-43, June 1993. (47] W. Harvey. Personal communication, 1993. [48] W. Harvey, D. Kalp , M. Tambe,, D. McKeown, and A. Newell...taski>) ((done-task "name chicken) <task2>) (remove <context> <taski> <task2>)j ( post leaving-customer (parp 1-check-out ADA289345 E.8. PARALLEL VERSION...ADA289345 Bibliography [] A. Acharya and D. Kalp . Release notes for CParaOPS5 5.3 and ParaOPS5 4.4. This is distributed with the CParaOPS5 release on dravido

  16. Kapitalismens ud- eller afvikling?

    DEFF Research Database (Denmark)

    Czeskleba-Dupont, Rolf

    2015-01-01

    Ingen af David Harveys mange værker er hidtil blevet udgivet på dansk. Det har forlaget Solidaritet nu rådet bod på med udgivelsen af "17 modsætninger og enden på kapitalisme"......Ingen af David Harveys mange værker er hidtil blevet udgivet på dansk. Det har forlaget Solidaritet nu rådet bod på med udgivelsen af "17 modsætninger og enden på kapitalisme"...

  17. Endocrine Surgery: A Hopkins Legacy.

    Science.gov (United States)

    Udelsman, Robert

    2017-09-06

    : The field of Endocrine Surgery is linked to extraordinary contributions made by Hopkins leaders in surgery including William Stewart Halsted, Harvey Cushing, and John L Cameron. Halsted's contributions to the anatomic basis of thyroid and parathyroid surgery were based on his experimental and clinical work performed at Johns Hopkins Hospital. Halsted's disciple, Harvey Cushing, created the field of modern neurosurgery and recognized the disease and syndrome that are immortalized with his name. The Halstedian principles promulgated and transmitted by John L Cameron to subsequent generations of endocrine surgeons at Hopkins have transformed the field of Endocrine Surgery with the stamp of Johns Hopkins Hospital.

  18. Cultural Resources Survey, Harry S. Truman Dam and Reservoir Project, Missouri. Volume 2. Historical Resources: Historical Gazetteer and Mitigation Recommendations.

    Science.gov (United States)

    1983-02-01

    Brauersville (Benton) P.O. 1886-97 and small village in Union T. named for Frederick Brauer (born about 1826) who served as postmaster for 8 years. PG Brickley...1894 for Fred Harvey, owner of the 0 Harvey restaurants. Town called Garland. Harviell (Henry) 10 m. NW of Clinton, 4 m. SE of Church. S WW, 399...Writsburg (Bates) Filling station on Highway 71 established about 1930 by Fred Wright. RJ Wright School (Cedar) 4 Family name. SSR Wright’s Creek (St

  19. Terrorism Information Management Within the New York City Fire Department: Past, Present and Future

    Science.gov (United States)

    2007-03-01

    and Bill Manning, “One Meridian Plaza,” Fire Engineering Magazine, August 1991, 51-70. 70 Harvey Eisner, “Towering Inferno ,” Firehouse Magazine...California, 496 U.S. 128, 136-137 (1990); Texas v. Brown , 460 U.S. 730, 739 (1983). 101 officials are lawfully in a position from which they view an...Towering Inferno .” Firehouse Magazine. October 1988, 51-58. Eisner, Harvey and Bill Manning. “One Meridian Plaza.” Fire Engineering Magazine. August

  20. 围头湾5种海藻提取物 AChE 抑制活性与 DPPH.清除能力的比较%Acetyl Choline Enzyme Inhibitory Activity and DPPH. Radical Scavenging Capacity of the Extracts from Five Seaweeds in Fujian Weitou Bay

    Institute of Scientific and Technical Information of China (English)

    黄晓冬; 李裕红; 黄晓昆; 戴聪杰

    2015-01-01

    对福建省围头海域5种海藻提取物及萃取部位的乙酰胆碱酶抑制活性与 DPPH.清除能力进行比较研究,并分别测定其总酚与总黄酮含量.结果表明:裙带菜与羊栖菜提取物具有较高含量的总酚与总黄酮;裙带菜的乙酸乙酯部位、二氯甲烷部位和羊栖菜石油醚部位、二氯甲烷部位在10 mg/mL 质量浓度时表现出较强的乙酰胆碱酶抑制活性,并且裙带菜乙酸乙酯部位、二氯甲烷部位以及羊栖菜二氯甲烷部位的DPPH.清除能力均明显高于其他提取物或萃取部位.%The acetyl choline enzyme inhibitory activity and DPPH. radical scavenging capacity of the extracts and its solvent fraction from five kinds of seaweed in Fujian Weitou bay were studied.Results showed that the exracts from Undaria pinnatifida and Sargassum fusiforme had higher concentra-tion of polyphenols and flavonoids.Ethyl acetate fraction and methylene chloride fraction from Un-daria pinnatifida,petroleum ether fraction and dichloromethane fraction from Sargassum fusiforme had strong acetylcholine enzyme inhibitory activity at 10 mg/mL.At the concentration of 1 mg/mL, the DPPH . scavenging abilities of ethyl acetate fraction and methylene chloride fraction from Un-daria pinnatifida ,dichloromethane fraction from Sargassum fusiforme were higher than other ex-tracts or fractions.

  1. Bioactivity of Phycocolloids against the Mediterranean Protozoan Leishmania infantum: An Inceptive Study

    Directory of Open Access Journals (Sweden)

    Simona Armeli Minicante

    2016-11-01

    Full Text Available Sulfated polysaccharides from marine macroalgae have been shown to possess a variety of biological activities against fungi, bacteria, viruses, and protozoa. In this study, the in vitro activity of algal polysaccharides against Leishmania infantum (Kinetoplastida: Trypanosomatidae was investigated. The polysaccharides were extracted from different macroalgae of the Mediterranean Sea: Chaetomorpha linum, Agardhiella subulata, Gracilaria viridis, Gracilaria bursa-pastoris, Hypnea cornuta, Sargassum muticum, and Undaria pinnatifida. Preliminary results showed a good anti-leishmanial activity of the investigated species, encouraging the focus on their use as natural resources in order to match integrated management strategies for the employment of local macroalgae.

  2. Consumo de algas marinas: su influencia en el valor nutritivo de la dieta y en diversos parámetros fisiológicos

    OpenAIRE

    Millán Lence, Rosendo

    2016-01-01

    En general, las algas marinas son una buena fuente de fibra al mismo tiempo que proporcionan vitaminas, minerales y nutracéuticos de interés para la alimentación humana. Por ello, en este estudio se analiza cómo influye la ingesta de las algas marinas Porphyra purpurea, Undaria pinnatifida, Himanthalia elongata, Ulva rigida y Codium tomentosum en la calidad nutritiva del alimento y en diversos parámetros hemáticos. Debido a que las enzimas implicadas en los procesos digestivos se adaptan a la...

  3. Analysis by Vibrational Spectroscopy of Seaweed Polysaccharides with Potential Use in Food, Pharmaceutical, and Cosmetic Industries

    Directory of Open Access Journals (Sweden)

    Leonel Pereira

    2013-01-01

    Full Text Available Polysaccharides present in several seaweeds (Kappaphycus alvarezii, Calliblepharis jubata, and Chondrus crispus—Gigartinales, Rhodophyta; Gelidium corneum and Pterocladiella capillacea—Gelidiales, Rhodophyta; Laurencia obtusa—Ceramiales, Rhodophyta; Himanthalia elongata, Undaria pinnatifida, Saccorhiza polyschides, Sargassum vulgare, and Padina pavonica—Phaeophyceae, Ochrophyta are analyzed by spectroscopic techniques. The nature of the polysaccharides (with extraction and without any type of extraction present in these seaweeds was determined with FTIR-ATR and FT-Raman analysis of extracted phycocolloids and ground dry seaweed.

  4. Natural Abundance 14C Content of Dibutyl Phthalate (DBP from Three Marine Algae

    Directory of Open Access Journals (Sweden)

    Kazuyo Ukai

    2006-11-01

    Full Text Available Abstract: Analysis of the natural abundance 14C content of dibutyl phthalate (DBP from two edible brown algae, Undaria pinnatifida and Laminaria japonica, and a green alga, Ulva sp., revealed that the DBP was naturally produced. The natural abundance 14C content of di-(2-ethylhexyl phthalate (DEHP obtained from the same algae was about 50-80% of the standard sample and the 14C content of the petrochemical (industrial products of DBP and DEHP were below the detection limit.

  5. NCBI nr-aa BLAST: CBRC-DNOV-01-3183 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-3183 ref|ZP_01986272.1| two component sensor histidine kinase [Vibrio harvey...i HY01] gb|EDL69079.1| two component sensor histidine kinase [Vibrio harveyi HY01] ZP_01986272.1 8.9 40% ...

  6. NCBI nr-aa BLAST: CBRC-TTRU-01-1109 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-1109 ref|ZP_06176703.1| gamma-glutamyl phosphate reductase [Vibrio harvey...i 1DA3] gb|EEZ86958.1| gamma-glutamyl phosphate reductase [Vibrio harveyi 1DA3] ZP_06176703.1 1.6 29% ...

  7. NCBI nr-aa BLAST: CBRC-GACU-08-0001 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GACU-08-0001 ref|YP_001444789.1| hypothetical protein VIBHAR_01592 [Vibrio harvey...i ATCC BAA-1116] gb|ABU70562.1| hypothetical protein VIBHAR_01592 [Vibrio harveyi ATCC BAA-1116] YP_001444789.1 2.5 24% ...

  8. NCBI nr-aa BLAST: CBRC-TTRU-01-1109 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-1109 ref|YP_001444380.1| gamma-glutamyl phosphate reductase [Vibrio harvey...i ATCC BAA-1116] gb|ABU70153.1| hypothetical protein VIBHAR_01163 [Vibrio harveyi ATCC BAA-1116] YP_001444380.1 1.6 29% ...

  9. NCBI nr-aa BLAST: CBRC-EEUR-01-1262 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-1262 ref|YP_001445076.1| choline/carnitine/betaine transporter [Vibrio harvey...i ATCC BAA-1116] gb|ABU70849.1| hypothetical protein VIBHAR_01883 [Vibrio harveyi ATCC BAA-1116] YP_001445076.1 1.6 30% ...

  10. An example of special Lagrangian fibration

    Institute of Scientific and Technical Information of China (English)

    FU Jixiang

    2005-01-01

    On the total space of the line bundle π: π*1T*P1(◎)π2*T*P1 → P1× P1, acomplete Ricci-flat Kaehler metric and a smooth special Lagrangian fibration are given.This special Lagrangian fibration is smoothly built up of 4 Harvey-Lawson's models in 4directions.

  11. 76 FR 53707 - Qualification of Drivers; Exemption Applications; Diabetes Mellitus

    Science.gov (United States)

    2011-08-29

    ... Federal Motor Carrier Safety Administration Qualification of Drivers; Exemption Applications; Diabetes Mellitus AGENCY: Federal Motor Carrier Safety Administration (FMCSA), DOT. ACTION: Notice of final... D. Stevenson, Oleg Tarasov, Richard H. Willis, and Harvey N. Woody from the ITDM standard in 49 CFR...

  12. American Red Cross

    Science.gov (United States)

    ... Know You’re Safe – Use Red Cross App and Website » Returning Home – Use Red Cross Flood Safety Steps » Red Cross Relief Efforts in the Caribbean & Mexico » At-a-Glance: Red Cross Response to Harvey, ...

  13. Teaching Biology in a Wider Context: The History of the Discipline as a Method 2: Worked Examples.

    Science.gov (United States)

    Russell, Nicholas

    1988-01-01

    Reviewed are three controversial incidents from the history of biomedical science for the lessons they may teach about the nature and context of scientific discoveries. Considered are William Harvey and blood circulation, Louis Pasteur and spontaneous generation, and Frederick Banting's discovery of insulin. (Author/CW)

  14. Instructional Media.

    Science.gov (United States)

    Journal of College Science Teaching, 1984

    1984-01-01

    Reviews a six-part series (available as 16mm film or videocassettes) in which actors portray scientists lecturing on various topics/issues. Scientists portrayed include Louis Pasteur, Charles Darwin, William Harvey, Gregor Mendel, William Beaumont, and Hans Spemann. Also reviews a film detailing construction of the Multiple Mirror Telescope on…

  15. The life and legacy of William T. Bovie.

    Science.gov (United States)

    Carter, Preston L

    2013-05-01

    This Historian's Address, presented at the North Pacific Surgical Association 2012 meeting, held in Spokane, Washington, on November 9, 2012, briefly reviews the life and surgical contributions of the inventor William T. Bovie and his collaboration with Dr Harvey Cushing, which led to the widespread acceptance of surgical electrocautery for dissection and hemostasis.

  16. Blood flow in the human fetal descending aorta : a pulsed Doppler study

    NARCIS (Netherlands)

    L. Pijpers (Leendert)

    1985-01-01

    textabstractIn 1628 William Harvey introduced his concept ofthe human circulation. Although a lot of studies concerning the fetal circulation were done before it was not until the 1930s that Barcroft (1934, 1939) and associates performed radiograpbic studies on the feta! goal and lamb to establish t

  17. Somatostatin and dopamine receptors as molecular targets for the medical treatment of Cushing’s disease

    NARCIS (Netherlands)

    C. de Bruin (Christiaan)

    2009-01-01

    textabstractHarvey Williams Cushing (1869-1939) was born as the 10th child of a well-educated, puritanical medical family in Cleveland (figure 1). He attended Yale University, graduated cum laude from Harvard Medical School and was trained as a general surgeon at Johns Hopkins under the famous but d

  18. The scientific renaissance 1450-1630

    CERN Document Server

    Hall, Marie Boas

    1994-01-01

    Stimulating, illuminating, and thoughtfully presented, this study explores the early stages of the scientific revolution. A noted historian of science examines the Copernican revolution, the anatomical work of Vesalius, the work of Paracelsus, Harvey's discovery of the circulatory system, the effects of Galileo's telescopic discoveries, and much more.

  19. Modernization Through Education: The Answer for Combating Terrorism?

    Science.gov (United States)

    2011-06-01

    17 Paul Zarembka, The Hidden History of 9-11-2001, 1st ed. (Amsterdam; Oxford: Elsevier JAI, 2006). 18 La Voz de Aztlan, ―Palestinian Women Martyrs...RQT=309&VName=PQD. Kushner, Harvey W. Encyclopedia of Terrorism. Thousand Oaks, CA: Sage Publications, 2003. La Voz de Aztlan. ―Palestinian Women

  20. How Does a Cowboy Make Money? Using Student Curiosities to Further Elementary School Inquiries

    Science.gov (United States)

    Whitlock, Annie McMahon; Brugar, Kristy A.

    2017-01-01

    This article explores examples of student-initiated inquiries (in Grades 1 and 5) and the opportunities and challenges with engaging in them. To explore these student-initiated inquiries, we use the "C3 Framework" Inquiry Arc (National Council for the Social Studies, 2013) and Harvey and Daniels's (2009) Small-Group Inquiry Model to…

  1. Learning from the Past, Building for the Future

    Science.gov (United States)

    Brand, Noreen B.

    2013-01-01

    The Illinois Holocaust Museum and Education Center (IHMEC) strives to engage youth as citizens through "Make a Difference! The Harvey L. Miller Family Youth Exhibition." Teaching about the Holocaust is complex and challenging work. Holocaust education is mandated in Illinois elementary and high schools, yet the Museum finds that many…

  2. Looking Forward to the Year 2000: Public Policy and Philanthropy. Working Papers, Spring Research Forum (San Francisco, California, March 17-18, 1988).

    Science.gov (United States)

    Independent Sector, Washington, DC.

    Forty-six working papers for presentation at a research forum on public policy and philanthropy are presented. Thirteen sections include the following topics: (1) looking forward to the year 2000: public policy and philanthropy (e.g. "Rationales for Tax Exemption," by Harvey P. Dale); (2) shifting boundaries among the sectors (e.g. "The Shifting…

  3. Further Food for Thought on the "ABS Guide"

    Science.gov (United States)

    Hussain, Simon

    2012-01-01

    This paper replies to points raised by the editors of the "ABS Guide", Huw Morris, Charles Harvey, Aidan Kelly and Michael Rowlinson (2011) "Accounting Education: an international journal", 20(6), pp. 561-573) in response to a paper published in a previous issue of "Accounting Education" (Hussain, S. (2011)…

  4. USA folkloristid tutvustavad Eestis afroameerika rahvamuusikat / Andres Roost

    Index Scriptorium Estoniae

    Roost, Andres

    2008-01-01

    9. veebruaril tutvustavad USA folkloristid Anna Lomax Wood ja Todd Dunham Harvey Eesti Kirjandusmuuseumi saalis Tartus John A. Lomaxi (1867-1948) ja Alan Lomaxi (1915-2002) kogutud afroameerika folkloori, näidatakse dokumentaalfilmi "Land Where the Blues Began"

  5. In Excess of Epistemology: Siegel, Taylor, Heidegger and the Conditions of Thought

    Science.gov (United States)

    Williams, Emma

    2015-01-01

    Harvey Siegel's epistemologically-informed conception of critical thinking is one of the most influential accounts of critical thinking around today. In this article, I seek to open up an account of critical thinking that goes beyond the one defended by Siegel. I do this by re-reading an opposing view, which Siegel himself rejects as leaving…

  6. Suur müüdikonverents Tartus / Evelin Banhard

    Index Scriptorium Estoniae

    Banhard, Evelin

    2008-01-01

    Tartus toimunud rahvusvahelisest konverentsist "Suurte kultuuriliste ja kirjanduslike müütide saatus tänapäeval". Pikemalt Liisa Saariluoma, Jüri Talveti, Angelika Stefanova, Tanel Lepsoo, Caroline De Wagteri, Sonia Bravo Utrera, Ana Martinoska, Marin Laagi, Rutt Hinrikuse, Jeanne Elisabeth Gleseneri, Sabine Coelsch-Foisneri, Harvey L. Hixi ja Hannu K. Riikoneni ettekannetest

  7. A More Perfect Commodity: Bottled Water, Global Accumulation, and Local Contestation

    Science.gov (United States)

    Jaffee, Daniel; Newman, Soren

    2013-01-01

    Bottled water sits at the intersection of debates regarding the social and environmental effects of the commodification of nature and the ways neoliberal globalization alters the provision of public services. Utilizing Polanyi's concept of fictitious commodities and Harvey's work on accumulation by dispossession, this article traces bottled…

  8. 78 FR 25273 - Change in Bank Control Notices; Acquisitions of Shares of a Bank or Bank Holding Company

    Science.gov (United States)

    2013-04-30

    ... 30309: 1. Harvey Alan Sorkin, Palm Beach Gardens, Florida; to acquire at least 10 percent of the voting shares of Floridian Community Holdings, Inc., and thereby indirectly acquire voting shares of Floridian Community Bank, Inc., both of Davie, Florida. B. Federal Reserve Bank of Minneapolis (Jacqueline G....

  9. The Corpus Status of Literature in Teaching Sociology: Novels as "Sociological Reconstruction"

    Science.gov (United States)

    Carlin, Andrew P.

    2010-01-01

    Using fiction in teaching sociology involves what Harvey Sacks calls "sociological reconstruction". Numerous comments on teaching sociology provide advice and suggestions on the use of literature and "what counts" as "sociological" literature, including specific titles. This paper goes further: while the use of literature is a routine feature of…

  10. Suur müüdikonverents Tartus / Evelin Banhard

    Index Scriptorium Estoniae

    Banhard, Evelin

    2008-01-01

    Tartus toimunud rahvusvahelisest konverentsist "Suurte kultuuriliste ja kirjanduslike müütide saatus tänapäeval". Pikemalt Liisa Saariluoma, Jüri Talveti, Angelika Stefanova, Tanel Lepsoo, Caroline De Wagteri, Sonia Bravo Utrera, Ana Martinoska, Marin Laagi, Rutt Hinrikuse, Jeanne Elisabeth Gleseneri, Sabine Coelsch-Foisneri, Harvey L. Hixi ja Hannu K. Riikoneni ettekannetest

  11. An Examination of the Decision-Making Processes Used by Superintendents in Reducing School District Budgets

    Science.gov (United States)

    Slaven, Lori A.

    2014-01-01

    Purpose: The purpose of this study was to determine the degree of importance of Harvey et al.'s (1997) 13 problem-solving strategies for making retrenchment decisions on school district budgets as perceived by California superintendents of medium-sized school districts. Methodology: The subjects in the present study were 86 superintendents of…

  12. Folkloor bluusi sünnimaalt

    Index Scriptorium Estoniae

    2008-01-01

    9. veebruaril tutvustavad USA folkloristid Anna Lomax Wood ja Todd Dunham Harvey Eesti Kirjandusmuuseumi saalis Tartus John A. Lomaxi (1867-1948) ja Alan Lomaxi (1915-2002) kogutud afroameerika folkloori, näidatakse dokumentaalfilmi "Land Where the Blues Began" ja esineb Emajõe deltabluesi ansambel Bullfrog Brown

  13. Prevention of Breast Cancer Cell Transformation by Blockade of the AP-1 Transcription Factor

    Science.gov (United States)

    2001-10-01

    46. Roffier- Tarlov S, Jeremy J, Brown G, Tarlov E, Stolarov J, Chapman DL, Alexiou M, Papaioannou VE. Programmed cell death in the absence of c-Fos...Steeg (46) Gagliardi AR, Hennig B, Collins DC. Anties- gens on hepatic phase-I and phase-II enzyme PS, Hilsenbeck SG, Harvey JM, et al. The trogens

  14. Working Papers on Literacy No. 1.

    Science.gov (United States)

    Graff, Harvey J.; Jones, Stan; Street, Brian V.

    This document contains two extended papers and one shorter commentary that reflect a continuing debate between two schools of thought on literacy that have been called the "autonomous" and the "sociocultural.""The Persisting Power and Costs of the Literacy Myth" (Harvey J. Graff) argues that current discourse on literacy decline ignores more than…

  15. Mitigating against Epistemic Injustice in Educational Research

    Science.gov (United States)

    Frank, Jeff

    2013-01-01

    In this article, I argue that Harvey Siegel correctly points out the limitations of epistemic diversity in educational research. Building from Siegel's analysis, I argue that we need to move away from the language of epistemic diversity and to the language of epistemic injustice. Epistemic injustice allows us to do the work that epistemic…

  16. Health Information in Urdu (اردو)

    Science.gov (United States)

    ... Disabilities - اردو (Urdu) PDF Federal Emergency Management Agency Disaster Preparation and Recovery Emergency Supply List - English Emergency Supply List - اردو (Urdu) PDF Federal Emergency Management Agency Keeping Children Safe after Hurricane Harvey - English Keeping Children Safe ...

  17. The First 25 Years in Space. A Symposium.

    Science.gov (United States)

    Needell, Allan A., Ed.

    These proceedings, based on a symposium which examined the motivations, implications, accomplishments, and social impacts of the first 25 years in space, are presented in four sections. Section 1 includes an introduction by John Logsdon, a paper titled "Motivations for the Space Program: Past and Future" by Harvey Brooks, and comments by Bernard…

  18. Relationship of Academic Variables to National Council for Licensure Examination for Registered Nurse Performance of Graduates in a Selected Associate Degree Nursing Program.

    Science.gov (United States)

    Naron, Rosarica G.; Widlak, Frederic

    This report addresses the unstable and unsatisfactory performance of Chicago, Illinois' Olive-Harvey College's (OHC) associate degree nursing (ADN) graduates on the National Council Licensure Examination for Registered Nurses (NCLEX-RN). An ex post facto correlation study was designed to determine the worthiness of pre-nursing admission course…

  19. When the Exception Is the Rule: School Shootings, Bare Life, and the Sovereign Self

    Science.gov (United States)

    Shapiro, Harvey

    2015-01-01

    Much discourse on school shootings tends to imply a binary separation between what is considered normal and exceptional, between an expected course of human events and sociohistorical aberrations. In this article Harvey Shapiro suggests the need for new directions in our responses: First, he shows how responses to school shootings tend to…

  20. GenBank blastx search result: AK104346 [KOME

    Lifescience Database Archive (English)

    Full Text Available e p21 proteins encoded by the human c-has/bas proto-oncogenes and transforming p21 proteins of the Harvey (v...-rasH) and Kirsten (v-rasK) murine sarcoma viral oncogenes.|PLN PLN 8e-47 +3 ...

  1. GenBank blastx search result: AK243597 [KOME

    Lifescience Database Archive (English)

    Full Text Available ith the p21 proteins encoded by the human c-has/bas proto-oncogenes and transforming p21 proteins of the Har...vey (v-rasH) and Kirsten (v-rasK) murine sarcoma viral oncogenes. PLN 1e-72 1 ...

  2. GenBank blastx search result: AK243329 [KOME

    Lifescience Database Archive (English)

    Full Text Available ith the p21 proteins encoded by the human c-has/bas proto-oncogenes and transforming p21 proteins of the Har...vey (v-rasH) and Kirsten (v-rasK) murine sarcoma viral oncogenes. PLN 2e-69 1 ...

  3. GenBank blastx search result: AK060246 [KOME

    Lifescience Database Archive (English)

    Full Text Available e p21 proteins encoded by the human c-has/bas proto-oncogenes and transforming p21 proteins of the Harvey (v...-rasH) and Kirsten (v-rasK) murine sarcoma viral oncogenes.|PLN PLN 3e-44 +2 ...

  4. GenBank blastx search result: AK112029 [KOME

    Lifescience Database Archive (English)

    Full Text Available e p21 proteins encoded by the human c-has/bas proto-oncogenes and transforming p21 proteins of the Harvey (v...-rasH) and Kirsten (v-rasK) murine sarcoma viral oncogenes.|PLN PLN 3e-44 +3 ...

  5. GenBank blastx search result: AK111986 [KOME

    Lifescience Database Archive (English)

    Full Text Available e p21 proteins encoded by the human c-has/bas proto-oncogenes and transforming p21 proteins of the Harvey (v...-rasH) and Kirsten (v-rasK) murine sarcoma viral oncogenes.|PLN PLN 1e-17 +3 ...

  6. GenBank blastx search result: AK111946 [KOME

    Lifescience Database Archive (English)

    Full Text Available e p21 proteins encoded by the human c-has/bas proto-oncogenes and transforming p21 proteins of the Harvey (v...-rasH) and Kirsten (v-rasK) murine sarcoma viral oncogenes.|PLN PLN 2e-54 +2 ...

  7. GenBank blastx search result: AK061969 [KOME

    Lifescience Database Archive (English)

    Full Text Available e p21 proteins encoded by the human c-has/bas proto-oncogenes and transforming p21 proteins of the Harvey (v...-rasH) and Kirsten (v-rasK) murine sarcoma viral oncogenes.|PLN PLN 8e-45 +2 ...

  8. Disinfection Alternatives for Small Communities in Puerto Rico

    Science.gov (United States)

    Disinfection Alternatives for Small Communities in Puerto Rico Craig Patterson1, Graciela Ramirez Toro2, Harvey Minnigh2, Cristina Maldonado3, and Rajib Sinha4 1U.S. EPA Office of Research and Development, 2Centro de Educación, Conservación e Interpretación Ambiental (CECIA),...

  9. Vietnamese Diasporic Placemaking: An Ethnographic Moment in Uneven Geographic Development

    Science.gov (United States)

    Nguyen, Thu Su'o'ng Thi

    2010-01-01

    The article explores the ways "uneven geographical development" conditions and is conditioned by local placemaking practices. Guided by David Harvey's work along with Henri Lefebvre's three dimensions of spatial production--spatial practices, representations of space, and spaces of representation or the "spatial imaginary"--I look at the ways a…

  10. The Creation of Experience Spaces

    DEFF Research Database (Denmark)

    Pedersen, Michael Thyrrestrup

    2013-01-01

    for the theoretical discussions, mainly inspired by Harvey (2009), Brenner (2004) and Mackinnon (2010), to put in to context the relations between national – regional – municipal, in the light of relational space (Massey, 2005) and the quality of place (Healey, 2010). The third space of Soja (1996) will be addressed...

  11. Mehed ruumis / Rosalyn Deutsche

    Index Scriptorium Estoniae

    Deutsche, Rosalyn

    2004-01-01

    1985. a. ilmunud T. J. Clarki raamatust "Modernse elu maalikunst: Pariis Manet' ja tema järgijate kunstis". 1989. a. ilmunud Edward W. Soja raamatust "Postmodernistlikud geograafiad" ja David Harvey raamatust "Postmodernne olukord". 1984. a. avaldatud Fredric Jamesoni artiklist "Postmodernism ehk hiliskapitalismi kultuuriline loogika". Bibliograafia lk. 81

  12. Disinfection Alternatives for Small Communities in Puerto Rico

    Science.gov (United States)

    Disinfection Alternatives for Small Communities in Puerto Rico Craig Patterson1, Graciela Ramirez Toro2, Harvey Minnigh2, Cristina Maldonado3, and Rajib Sinha4 1U.S. EPA Office of Research and Development, 2Centro de Educación, Conservación e Interpretación Ambiental (CECIA),...

  13. Geographic variation in thermal traits in Digenea simplex and Champia parvula (Rhodophyta) in relation to present and glacial temperature regimes

    NARCIS (Netherlands)

    Orfanidis, S; Breeman, AM

    1999-01-01

    Geographic variation in temperature responses (survival and growth) was investigated in two red algae: Digenea simplex (Wulfen) C. Agardh and Champia parvula (C. Agardh) Harvey. D. simplex has a tropical to warm temperate distribution; C. parvula extends from the tropics into the cold temperate zone

  14. The extraordinary amount of substructure in the Hubble Frontier Fields cluster Abell 2744

    Science.gov (United States)

    Jauzac, M.; Eckert, D.; Schwinn, J.; Harvey, D.; Baugh, C. M.; Robertson, A.; Bose, S.; Massey, R.; Owers, M.; Ebeling, H.; Shan, H. Y.; Jullo, E.; Kneib, J.-P.; Richard, J.; Atek, H.; Clément, B.; Egami, E.; Israel, H.; Knowles, K.; Limousin, M.; Natarajan, P.; Rexroth, M.; Taylor, P.; Tchernin, C.

    2016-12-01

    We present a joint optical/X-ray analysis of the massive galaxy cluster Abell 2744 (z = 0.308). Our strong- and weak-lensing analysis within the central region of the cluster, i.e. at R cross-section of dark matter of σDM CL), in good agreement with previous results from Harvey et al.

  15. Testing for a Common Volatility Process and Information Spillovers in Bivariate Financial Time Series Models

    NARCIS (Netherlands)

    J. Chen (Jinghui); M. Kobayashi (Masahito); M.J. McAleer (Michael)

    2016-01-01

    textabstractThe paper considers the problem as to whether financial returns have a common volatility process in the framework of stochastic volatility models that were suggested by Harvey et al. (1994). We propose a stochastic volatility version of the ARCH test proposed by Engle and Susmel (1993),

  16. Methods in algorithmic analysis

    CERN Document Server

    Dobrushkin, Vladimir A

    2009-01-01

    …helpful to any mathematics student who wishes to acquire a background in classical probability and analysis … This is a remarkably beautiful book that would be a pleasure for a student to read, or for a teacher to make into a year's course.-Harvey Cohn, Computing Reviews, May 2010

  17. 75 FR 78601 - Drawbridge Operation Regulation; Gulf Intracoastal Waterway, New Orleans Harbor, Inner Harbor...

    Science.gov (United States)

    2010-12-16

    ... Orleans Harbor, Inner Harbor Navigation Canal, New Orleans, Orleans Parish, LA AGENCY: Coast Guard, DHS... Seeber/Claiborne Avenue) ] vertical lift bridge across the Inner Harbor Navigational Canal, mile 0.9, (Gulf Intracoastal Waterway mile 6.7 East of Harvey Lock), at New Orleans, Orleans Parish,...

  18. 76 FR 8653 - Drawbridge Operation Regulation; Gulf Intracoastal Waterway, New Orleans Harbor, Inner Harbor...

    Science.gov (United States)

    2011-02-15

    ... Orleans Harbor, Inner Harbor Navigation Canal, New Orleans, Orleans Parish, LA AGENCY: Coast Guard, DHS... Seeber/Claiborne Avenue) vertical lift bridge across the Inner Harbor Navigational Canal, mile 0.9, (Gulf Intracoastal Waterway mile 6.7 East of Harvey Lock), at New Orleans, Orleans Parish, Louisiana. This...

  19. 6 Schools that Make a Difference: With the Support of Focus on Results, These Six Schools Beat the Odds by Using Common Sense Strategies in a Focused Effort to Improve Student Achievement

    Science.gov (United States)

    Cudeiro, Amalia; Palumbo, Joe; Leight, Jan; Nelsen, Jeff

    2005-01-01

    More and more schools in California and across the nation are showing that when school communities accept the possibility and responsibility of bringing all of their students to proficiency levels, they can do amazing things. Six schools located in southern California--Martin Luther King and Harvey of Santa Ana Unified, Morrison Elementary of…

  20. Concept study and validation of Antartic telescope tower

    NARCIS (Netherlands)

    Lanford, E.; Swain, M.; Meyers, C.; Muramatsu, T.; Nielson, G.; Olson, V.; Ronsse, S.; Vinding Nyden, E.; Hammerschlag, R.H.; Little, P.

    2006-01-01

    Studies by Mark Swain and a colleague at the Max Planck Institut für Astronomie, coupled with results from past and ongoing projects at Harvey Mudd College, strongly suggest that it may be possible to achieve imaging performance comparable to the Hubble Space Telescope at relatively low cost using a

  1. Moodne materjal / Liina Jänes

    Index Scriptorium Estoniae

    Jänes, Liina, 1977-

    2005-01-01

    Uusim betoonarhitektuur maailmas: Chichu Kunstimuuseum Naoshima saarel ja eramu "4x4" (arhitekt Tadao Ando), Wolfsburgi teaduskeskus Saksamaal (arhitekt Zaha Hadid), krematoorium Berliinis (arhitekt Axel Schultes), Utrechti ülikooli raamatukogu (arhitekt Wiel Arets), tuleviku betoonmaja The Concrete House (arhitektid Peter Poulet, Michael Harvey). 10 värv. ill

  2. Philosophy, Philosophy of Education, and Economic Realities

    Science.gov (United States)

    White, John

    2013-01-01

    In 2009 Harvey Siegel edited "The Oxford Handbook of Philosophy of Education." This article develops a theme, prompted by reflection on several essays in that volume, about the nature of philosophy of education and its relation to philosophy. Siegel's view that philosophy of education is a "branch" of philosophy is put to…

  3. The White Majority: Between Poverty and Affluence.

    Science.gov (United States)

    Howe, Louise Kapp, Ed.

    Contents of this book include: "Introduction," Louise Kapp Howe; "The revolt of the white lower-middle class," Pete Hamill; "Life with Cappelli on $101 a week," Harvey Aronson; "Blue-collar marriages and families," Mirra Komarovsky; "Working-class youth: alienation without an image," William Simon and John H. Gagnon; "Greasers, Dupers and Hippies:…

  4. Neo-Liberalism, Irish Society and Adult Education

    Science.gov (United States)

    Finnegan, Fergal

    2008-01-01

    This article offers an overview of recent international scholarship on neo-liberalism in particular the work of the geographer and historian David Harvey and the recent books of the educationalist Henry Giroux. It begins with a brief historical account of neo-liberalism and outlines the main characteristics of the free market era. Irish society…

  5. Mehed ruumis / Rosalyn Deutsche

    Index Scriptorium Estoniae

    Deutsche, Rosalyn

    2004-01-01

    1985. a. ilmunud T. J. Clarki raamatust "Modernse elu maalikunst: Pariis Manet' ja tema järgijate kunstis". 1989. a. ilmunud Edward W. Soja raamatust "Postmodernistlikud geograafiad" ja David Harvey raamatust "Postmodernne olukord". 1984. a. avaldatud Fredric Jamesoni artiklist "Postmodernism ehk hiliskapitalismi kultuuriline loogika". Bibliograafia lk. 81

  6. Pop / Tõnis Kahu

    Index Scriptorium Estoniae

    Kahu, Tõnis, 1962-

    2004-01-01

    Heliplaatidest: Patti Smith "Trampin", PJ Harvey "Uh Huh Her", Erinevad esitajad "Julm kauamängiv No.1", Method Man "Tical O: The Prequel", The Carpenters "Gold", ZZ Top "Rancho Texicano: The Very Best of ZZ Top", Rüki "Davenport"

  7. Saving Our Sons: The Impact of a Single Gender Public School on the Social, Emotional and Academic Progress of Young African American Males from Low Socioeconomic Urban Neighborhoods

    Science.gov (United States)

    Murphy, Robert L.

    2013-01-01

    African American males consistently perform at significantly lower academic levels, than their peers, at every age level and on almost every national assessment (Lewis, Simon, Uzzell, Horwitz, & Casserly, 2010; Harvey, 2010; Tsoi-A-Fatt, 2010; Fergus & Noguera, 2010), and of all racial/ethnic and gender groups, African American males…

  8. Instructional Media.

    Science.gov (United States)

    Journal of College Science Teaching, 1984

    1984-01-01

    Reviews a six-part series (available as 16mm film or videocassettes) in which actors portray scientists lecturing on various topics/issues. Scientists portrayed include Louis Pasteur, Charles Darwin, William Harvey, Gregor Mendel, William Beaumont, and Hans Spemann. Also reviews a film detailing construction of the Multiple Mirror Telescope on…

  9. The Corpus Status of Literature in Teaching Sociology: Novels as "Sociological Reconstruction"

    Science.gov (United States)

    Carlin, Andrew P.

    2010-01-01

    Using fiction in teaching sociology involves what Harvey Sacks calls "sociological reconstruction". Numerous comments on teaching sociology provide advice and suggestions on the use of literature and "what counts" as "sociological" literature, including specific titles. This paper goes further: while the use of literature is a routine feature of…

  10. Exophthalmos: A Forgotten Clinical Sign of Cushing's Syndrome.

    Science.gov (United States)

    Giugni, Aldo Schenone; Mani, Shylaja; Kannan, Subramanian; Hatipoglu, Betul

    2013-01-01

    Exophthalmos is typically associated with Graves' ophthalmopathy. Although originally described by Harvey Cushing, exophthalmos is an underappreciated sign of Cushing's syndrome. We present a case of a 38-year-old female who presented with severe bilateral proptosis and was subsequently diagnosed with Cushings disease. We discuss the possible mechanisms causing exophthalmos in patients with either endogenous or exogenous hypercortisolemia.

  11. Exophthalmos: A Forgotten Clinical Sign of Cushing's Syndrome

    Directory of Open Access Journals (Sweden)

    Aldo Schenone Giugni

    2013-01-01

    Full Text Available Exophthalmos is typically associated with Graves' ophthalmopathy. Although originally described by Harvey Cushing, exophthalmos is an underappreciated sign of Cushing's syndrome. We present a case of a 38-year-old female who presented with severe bilateral proptosis and was subsequently diagnosed with Cushings disease. We discuss the possible mechanisms causing exophthalmos in patients with either endogenous or exogenous hypercortisolemia.

  12. Folkloor bluusi sünnimaalt

    Index Scriptorium Estoniae

    2008-01-01

    9. veebruaril tutvustavad USA folkloristid Anna Lomax Wood ja Todd Dunham Harvey Eesti Kirjandusmuuseumi saalis Tartus John A. Lomaxi (1867-1948) ja Alan Lomaxi (1915-2002) kogutud afroameerika folkloori, näidatakse dokumentaalfilmi "Land Where the Blues Began" ja esineb Emajõe deltabluesi ansambel Bullfrog Brown

  13. The influence of dietary energy concentration and feed intake level ...

    African Journals Online (AJOL)

    DM digestibility was not influenced (P = 0.28) by feeding level, but was linearly reduced (P EO 0.05) as C: R ratio decreased ... and in C: R ratio increased rumen OM retention linearly (P EO 0.1>1).Volatile fatty .... program of Harvey (1977).

  14. New Cadets and other College Freshmen Class of 1986

    Science.gov (United States)

    1983-04-01

    academic reputation (87%), special education programs (46%), and financial assistance (45%). 4. Cadet political identification remained largely...Very High Selectivity (1,175 or more on SAT-V 4 SAT-M) 1. Anharst College 14. Harvey Mudd College 2. Barnard College IS. Mount Holyoke College 3

  15. Examining Technology's Impact on Society: Using Case Studies to Introduce Environmental and Economic Considerations

    Science.gov (United States)

    Karukstis, Kerry K.

    2003-01-01

    The general chemistry course at Harvey Mudd College presents chemical principles and addresses technology's impact on society. Students consider environmental and economic implications of chemical scenarios in real-world case studies created for team-based analysis and discussion. Case study design, implementation, and assessment are presented.…

  16. USA folkloristid tutvustavad Eestis afroameerika rahvamuusikat / Andres Roost

    Index Scriptorium Estoniae

    Roost, Andres

    2008-01-01

    9. veebruaril tutvustavad USA folkloristid Anna Lomax Wood ja Todd Dunham Harvey Eesti Kirjandusmuuseumi saalis Tartus John A. Lomaxi (1867-1948) ja Alan Lomaxi (1915-2002) kogutud afroameerika folkloori, näidatakse dokumentaalfilmi "Land Where the Blues Began"

  17. NCBI nr-aa BLAST: CBRC-OLAT-26-0094 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OLAT-26-0094 ref|YP_001446918.1| hypothetical protein VIBHAR_04782 [Vibrio harvey...i ATCC BAA-1116] gb|ABU72691.1| hypothetical protein VIBHAR_04782 [Vibrio harveyi ATCC BAA-1116] YP_001446918.1 4e-26 26% ...

  18. NCBI nr-aa BLAST: CBRC-GACU-08-0001 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GACU-08-0001 ref|ZP_01985206.1| gonadoliberin III-related protein [Vibrio harvey...i HY01] gb|EDL70206.1| gonadoliberin III-related protein [Vibrio harveyi HY01] ZP_01985206.1 2.5 24% ...

  19. Consensus report on the future of animal-free systemic toxicity testing

    Science.gov (United States)

    This is a multi-authored consensus report from conferences held in 2011-2012. Complete author listing is as follows: Marcel Leist1,2, Nina Hasiwa1, Costanza Rovida1, Mardas Daneshian1, David Basketter3, Ian Kimber4, Harvey Clewell5, Tilman Gocht6, Alan Goldberg7, Derek Knight8, G...

  20. 75 FR 3263 - Self-Regulatory Organizations; The NASDAQ Stock Market LLC; Notice of Filing of Amendment Nos. 2...

    Science.gov (United States)

    2010-01-20

    ... (January 22, 2009), 74 FR 5193. \\4\\ Letters to Elizabeth M. Murphy, Secretary, Commission, from Harvey... Executive Officer, Lek Securities Corporation, dated June 15, 2009 (``Lek Letter''); letter to David S..., 2009 (``FTEN II Letter''); letter to James Brigagliano, Co-Acting Director, David Shillman,...

  1. 76 FR 3516 - Drawbridge Operation Regulation; Gulf Intracoastal Waterway, Belle Chasse, LA

    Science.gov (United States)

    2011-01-20

    ...: If you have questions on this rule, call or e-mail David Frank, Bridge Administration Branch; telephone 504-671-2128, e-mail David.m.frank@uscg.mil . If you have questions on viewing the docket, call... the Gulf Intracoastal Waterway (Harvey Canal) to avoid unnecessary delays. The Coast Guard...

  2. 77 FR 64583 - Qualification of Drivers; Exemption Applications; Vision

    Science.gov (United States)

    2012-10-22

    ... decided to extend each exemption for a renewable two-year period. They are: Paul G. Albrecht (WI) David W. Brown (TN) Monty G. Calderon (OH) Awilda S. Colon (TN) Zane G. Harvey, Jr. (VA) Jeffrey M. Keyser (OH) Donnie A. Kildow (ID) Daniel A. McNabb (KS) David G. Meyers (NY) Rodney M. Pegg (PA) Raymond E....

  3. 75 FR 75542 - Qualification of Drivers; Exemption Renewals; Vision

    Science.gov (United States)

    2010-12-03

    ... Federal vision exemptions for Paul G. Albrecht, Elijah A. Allen, Jr., David W. Brown, Monty G. Calderon, Awilda S. Colon, David M. Hagadorn, Zane G. Harvey, Jr., Jeffrey M. Keyser, Donnie A. Kildow, Daniel A. McNabb, David G. Meyers, Thomas L. Oglesby, Michael J. Paul, Russell A. Payne, Rodney M....

  4. 77 FR 45363 - Government-Owned Inventions; Availability for Licensing

    Science.gov (United States)

    2012-07-31

    ... available. Inventors: Qing-Rong Liu, Mikko Airavaara, Barry Hoffer, Brandon K Harvey (all of NIDA...-262-2005/0-US-06). Multiple additional patent families. Licensing Contact: David A. Lambertson, Ph.D... HNO. Development Stage Early-stage. Pre-clinical. Inventors: David A. Wink and Larry K. Keefer...

  5. 77 FR 32393 - Drawbridge Operation Regulation; Gulf Intracoastal Waterway, LA

    Science.gov (United States)

    2012-06-01

    ... the Lapalco Boulevard bascule span drawbridge across the Harvey Canal Route, Gulf Intracoastal... Federal holidays. FOR FURTHER INFORMATION CONTACT: If you have questions on this rule, call or email David Frank, Bridge Branch Office, Coast Guard; telephone 504-671-2128, email David.M.Frank@uscg.mil . If...

  6. 78 FR 6208 - Drawbridge Operating Regulations; Gulf Intracoastal Waterway, Belle Chasse, LA

    Science.gov (United States)

    2013-01-30

    ... have questions on this temporary deviation, call or email David Frank, Bridge Administration Branch, Coast Guard, telephone (504) 671-2128, email David.m.frank@uscg.mil . If you have questions on viewing... Gulf Intracoastal Waterway (Harvey Canal) to avoid unnecessary delays. The Coast Guard has...

  7. 77 FR 75554 - Drawbridge Operation Regulation; Apalachicola River, FL

    Science.gov (United States)

    2012-12-21

    ...) requested to maintain the swing bridge at mile 4.5 (GIWW mile 347.0 East of Harvey Lock (EHL)), at.... FOR FURTHER INFORMATION CONTACT: If you have questions on this final rule, call or email David Frank, Bridge Administration Branch; telephone 504-671-2128, email David.M.Frank@uscg.mil . If you...

  8. Writing Resistance: Sleeplessness, Poetry, and the Right to the City under Financial Capitalism

    NARCIS (Netherlands)

    Pape, T.

    2014-01-01

    A review of Berardi, Franco "Bifo." 2012. The Uprising: On Poetry and Finance. Los Angeles/ Cambridge: Semiotext(e)/MIT Press. Crary, Jonathan. 2013. 24/7: Late Capitalism and the Ends of Sleep. London/New York: Verso. Harvey, David. 2013. Rebel Cities: From the Right to the City to the Urban Revolu

  9. A neurologist in the origin of European and International neurosurgery: Clovis-Julien-Désiré Vincent (1879-1947).

    Science.gov (United States)

    Androutsos, G; Karamanou, M; Lymberi, M; Zambelis, T; Stamboulis, E

    2011-01-01

    Vincent Clovis began his carrier as a neurologist and finally became neurosurgeon at an advanced age. He is considered the founder of French neurosurgery, and after Harvey Williams Cushing, Europe's first neurosurgeon. He was mainly interested in pituitary tumors, in cerebral abscesses and in cerebral oedema.

  10. PATTERNS OF SEVEN AND COMPLICATED MALARIA IN CHILDREN

    African Journals Online (AJOL)

    GB

    diagnosis or lack of it are all adding fuel to the already fired train of resistant microbes. CONCLUSION: ... success of antimicrobials against disease-causing microbes is .... wound management in hospitals, resulting in the .... Harvey Cushing/John Hay Whitney Medical. Library ... Initiative-an update: Proceedings of an expert.

  11. Studies on Typhus and Spotted Fever.

    Science.gov (United States)

    1981-02-01

    Heterogeneity among Rickettsia tsutsugamushi isolates: A protein analysis. 8. David J. Silverman, Charles L. Wisseman, Jr. and Anna Waddell. Envelopment and...the Conference and are also in press. 10. Paul Fiset, Charles L. Wisseman, Jr., A. Farhang-Azad, Harvey Fischman . Rocky Mountain Spotted Fever in

  12. A More Perfect Commodity: Bottled Water, Global Accumulation, and Local Contestation

    Science.gov (United States)

    Jaffee, Daniel; Newman, Soren

    2013-01-01

    Bottled water sits at the intersection of debates regarding the social and environmental effects of the commodification of nature and the ways neoliberal globalization alters the provision of public services. Utilizing Polanyi's concept of fictitious commodities and Harvey's work on accumulation by dispossession, this article traces bottled…

  13. Minimizing the Pervasiveness of Women's Personal Experiences of Gender Discrimination

    Science.gov (United States)

    Foster, Mindi D.; Jackson, Lydia C.; Hartmann, Ryan; Woulfe, Shannon

    2004-01-01

    Given the Rejection-Identification Model (Branscombe, Schmitt, & Harvey, 1999), which shows that perceiving discrimination to be pervasive is a negative experience, it was suggested that there would be conditions under which women would instead minimize the pervasiveness of discrimination. Study 1 (N= 91) showed that when women envisioned…

  14. Wallace Stevens: A Collection of Critical Essays. Twentieth Century Views Series.

    Science.gov (United States)

    Borroff, Marie, Ed.

    One of a series of works aimed at presenting contemporary critical opinion on major authors, this collection includes essays by Marie Borroff, Wallace Stevens, Joseph N. Riddle, Hi Simons, Sister M. Bernetta Quinn, C. Roland Wagner, Harold Bloom, Ralph J. Mills, Jr., Roy Harvey Pearce, Louis L. Martz, Morton Dauwen Zabel, and Northrop Frye--all…

  15. Line of Light Aid to Navigation,

    Science.gov (United States)

    1984-02-01

    1980. 5. Sharf , Bertram, et. al., Experimental Sensory Psychology, Scott, Foresman and Company, Glenview, Illinois, 1975, pp. 240-244. 6. Davy, E., "The...Schiffman, Harvey Richard , Sensation and Perception, John Wile3 Thns, Inc., New York, 1976, p. 190-192. 8. Arecchi, LCDR A. V. and LTJG D. J. Pietraszewski

  16. Student Perspectives on Quality in Higher Education

    Science.gov (United States)

    Jungblut, Jens; Vukasovic, Martina; Stensaker, Bjørn

    2015-01-01

    The study provides an insight into student perspectives on quality in higher education, using Harvey and Green conceptualizations as the point of departure, and exploring the linkages between the views on quality, the developments of the Bologna Process and related national reforms, as well as students' motivation for and expectations from higher…

  17. Instruction beyond the Facilitative Conditions: A Response to Biggs.

    Science.gov (United States)

    Holloway, Elizabeth L.

    1988-01-01

    Responds to Biggs' article on the case presentation approach in clinical supervision by discussing implications for instruction of two relevant research programs: conceptual level (Harvey, Hunt, and Schroder, 1961) and Hunt's related matching model for education, and Strohmer and associates' cognitive models for clinical judgment. (NB)

  18. Projective Hulls and Characterizations of Meromorphic Functions

    CERN Document Server

    Anderson, J T; Levenberg, N; Ransford, T J

    2011-01-01

    We give conditions characterizing holomorphic and meromorphic functions in the unit disk of the complex plane in terms of certain weak forms of the maximum principle. Our work is directly inspired by recent results of John Wermer, and by the theory of the projective hull of a compact subset of complex projective space developed by Reese Harvey and Blaine Lawson.

  19. More Value to Defining Quality

    Science.gov (United States)

    Van Kemenade, Everard; Pupius, Mike; Hardjono, Teun W.

    2008-01-01

    There are lots of definitions of quality, and also of quality in education. Garvin (1984) discerns five approaches: the transcendental approach, the product-oriented approach, the customer-oriented approach, the manufacturing-oriented approach and the value-for-money approach. Harvey and Green (1993) give five interrelated concepts of quality as:…

  20. The Budget and Economic Outlook: Fiscal Years 2012 to 2022

    Science.gov (United States)

    2012-01-01

    substantially as a percentage of GDP, decrease spending significantly from projected levels, or adopt some combi - nation of those two approaches...prepared by the Budget Analysis Division, supervised by Peter Fontaine, Theresa Gullo, Holly Harvey, Janet Airis, Tom Bradley, Kim Cawley, Jean Hearne