15 CFR 752.14 - System reviews.

Science.gov (United States)

2010-01-01

...) Other reviews. BIS may require an SCL holder or consignee to submit to its office a list of all sales... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false System reviews. 752.14 Section 752.14... LICENSE § 752.14 System reviews. (a) Post-license system reviews. BIS may conduct system reviews of the...

14 CFR 35.15 - Safety analysis.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Safety analysis. 35.15 Section 35.15... STANDARDS: PROPELLERS Design and Construction § 35.15 Safety analysis. (a)(1) The applicant must analyze the.... This analysis will take into account, if applicable: (i) The propeller system in a typical installation...

14 CFR 1300.15 - Loan terms.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Loan terms. 1300.15 Section 1300.15... DISASTER RELIEF-AIR CARRIER GUARANTEE LOAN PROGRAM Minimum Requirements and Application Procedures § 1300.15 Loan terms. (a) A loan guaranteed under the program shall be due and payable in full no later than...

15 CFR 325.14 - Submitting reports.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Submitting reports. 325.14 Section 325.14 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE MISCELLANEOUS REGULATIONS EXPORT TRADE CERTIFICATES...

Behavioral/Emotional Problems of Preschoolers: Caregiver/Teacher Reports from 15 Societies

Science.gov (United States)

Rescorla, Leslie A.; Achenbach, Thomas M.; Ivanova, Masha Y.; Bilenberg, Niels; Bjarnadottir, Gudrun; Denner, Silvia; Dias, Pedro; Dobrean, Anca; Dopfner, Manfred; Frigerio, Alessandra; Goncalves, Miguel; Guomundsson, Halldor; Jusiene, Roma; Kristensen, Solvejg; Lecannelier, Felipe; Leung, Patrick W. L.; Liu, Jianghong; Lobel, Sofia P.; Machado, Barbara Cesar; Markovic, Jasminka; Mas, Paola A.; Esmaeili, Elaheh Mohammad; Montirosso, Rosario; Pluck, Julia; Pronaj, Adelina Ahmeti; Rodriguez, Jorge T.; Rojas, Pamela O.; Schmeck, Klaus; Shahini, Mimoza; Silva, Jaime R.; van der Ende, Jan; Verhulst, Frank C.

2012-01-01

This study tested societal effects on caregiver/teacher ratings of behavioral/emotional problems for 10,521 preschoolers from 15 societies. Many societies had problem scale scores within a relatively narrow range, despite differences in language, culture, and other characteristics. The small age and gender effects were quite similar across…

15 CFR 785.14 - Extension of time.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Extension of time. 785.14 Section 785.14 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS ENFORCEMENT § 785.14...

Asymptotic normalization coefficients for 14N+p→15O and the astrophysical S factor for 14N(p,γ)15O

International Nuclear Information System (INIS)

Mukhamedzhanov, A.M.; Gagliardi, C.A.; Pirlepesov, F.; Tribble, R.E.; Bem, P.; Burjan, V.; Kroha, V.; Novak, J.; Piskor, S.; Simeckova, E.; Vincour, J.; Brown, B.A.; Nunes, F.M.

2003-01-01

The 14 N(p,γ) 15 O reaction, which controls energy production in the CNO cycle, has contributions from both resonance and direct captures to the ground and excited states. The overall normalization of the direct captures is defined by the corresponding asymptotic normalization coefficients (ANCs). Especially important is the ANC for the subthreshold state in 15 O at -0.504 keV since direct capture through this state dominates the reaction rate at stellar energies. In order to determine the ANCs for 14 N+p→ 15 O, the 14 N( 3 He,d) 15 O proton transfer reaction has been measured at an incident energy of 26.3 MeV. Angular distributions for proton transfer to the ground and five excited states were obtained. ANCs were then extracted from comparison to both distorted-wave Born approximation and coupled-channels Born approximation calculations. Using these ANCs, we calculated the astrophysical factor and reaction rates for 14 N(p,γ) 15 O. Our analysis favors a low value for the astrophysical factor

Space Physiology within an Exercise Physiology Curriculum

Science.gov (United States)

Carter, Jason R.; West, John B.

2013-01-01

Compare and contrast strategies remain common pedagogical practices within physiological education. With the support of an American Physiological Society Teaching Career Enhancement Award, we have developed a junior- or senior-level undergraduate curriculum for exercise physiology that compares and contrasts the physiological adaptations of…

Physiology knowledge plays a role when novices learn technical echocardiography skills

DEFF Research Database (Denmark)

Nielsen, Dorte Guldbrand; Gøtzsche, Ole; Eika, Berit

2010-01-01

Purpose: Little is known about factors of relevance for achieving technical skills of echocardiography (TTE); one of the essential skills defined by the European Society of Cardiology Core Curriculum. In an earlier study we have shown that there is a strong correlation between physiology knowledge...... and interpretation skills of intermediately trained echocardiographers. This study investigates the role of physiology knowledge in the development of echocardiographic technical expertise. Methods: Forty-five physicians (15 novices, 15 intermediates and 15 experts) were evaluated on technical skills. Participants...... of echocardiography relevant physiology knowledge. Results: A strong and significant correlation between expertise level and technical checklist scores was found (r = .76, p

15 CFR 14.13 - Debarment and suspension.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Debarment and suspension. 14.13 Section 14.13 Commerce and Foreign Trade Office of the Secretary of Commerce UNIFORM ADMINISTRATIVE... shall comply with the nonprocurement debarment and suspension common rule implementing E.O.s 12549 and...

15 CFR 14.11 - Pre-award policies.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Pre-award policies. 14.11 Section 14.11 Commerce and Foreign Trade Office of the Secretary of Commerce UNIFORM ADMINISTRATIVE REQUIREMENTS... used when the principal purpose is acquisition of property or services for the direct benefit or use of...

Proceedings of the Canadian Nuclear Society 15. annual conference

Energy Technology Data Exchange (ETDEWEB)

Huynh, H M [Hydro-Quebec, Montreal, PQ (Canada)

1994-12-31

The proceedings of the 15. annual conference of the Canadian Nuclear Society cover a wide range of nuclear topics, but the emphasis is on CANDU reactors and Canadian experience. The 89 papers are arranged in 17 sessions dealing with the following subjects: thermalhydraulics, fuel channels, operations, reactor physics, fuel, new technology, safety, training, waste management. The individual papers have been abstracted separately.

Proceedings of the Canadian Nuclear Society 15. annual conference

International Nuclear Information System (INIS)

Huynh, H.M.

1994-01-01

The proceedings of the 15. annual conference of the Canadian Nuclear Society cover a wide range of nuclear topics, but the emphasis is on CANDU reactors and Canadian experience. The 89 papers are arranged in 17 sessions dealing with the following subjects: thermalhydraulics, fuel channels, operations, reactor physics, fuel, new technology, safety, training, waste management. The individual papers have been abstracted separately

Synteny of human chromosomes 14 and 15 in the platyrrhines (Primates, Platyrrhini)

Science.gov (United States)

2009-01-01

In order to study the intra- and interspecific variability of the 14/15 association in Platyrrhini, we analyzed 15 species from 13 genera, including species that had not been described yet. The DNA libraries of human chromosomes 14 and 15 were hybridized to metaphases of Alouatta guariba clamitans, A. caraya, A. sara, Ateles paniscus chamek, Lagothrix lagothricha, Brachyteles arachnoides, Saguinus midas midas, Leontopithecus chrysomelas, Callimico goeldii, Callithrix sp., Cebus apella, Aotus nigriceps, Cacajao melanocephalus,Chiropotes satanas and Callicebus caligatus. The 14/15 hybridization pattern was present in 13 species, but not in Alouatta sara that showed a 14/15/14 pattern and Aotus nigriceps that showed a 15/14/15/14 pattern. In the majority of the species, the HSA 14 homologue retained synteny for the entire chromosome, whereas the HSA 15 homologue displayed fragmented segments. Within primates, the New World monkeys represent the taxon with the highest variability in chromosome number (2n = 16 to 62). The presence of the HSA 14/15 association in all species and subspecies studied herein confirms that this association is the ancestral condition for platyrrhines and that this association has been retained in most platyrrhines, despite the occurrence of extensive inter- and intrachromosomal rearrangements in this infraorder of Primates. PMID:21637455

Synteny of human chromosomes 14 and 15 in the platyrrhines (Primates, Platyrrhini

Directory of Open Access Journals (Sweden)

Cristiani Gifalli-Iughetti

2009-01-01

Full Text Available In order to study the intra- and interspecific variability of the 14/15 association in Platyrrhini, we analyzed 15 species from 13 genera, including species that had not been described yet. The DNA libraries of human chromosomes 14 and 15 were hybridized to metaphases of Alouatta guariba clamitans, A. caraya, A. sara, Ateles paniscus chamek, Lagothrix lagothricha, Brachyteles arachnoides, Saguinus midas midas, Leontopithecus chrysomelas, Callimico goeldii, Callithrix sp., Cebus apella, Aotus nigriceps, Cacajao melanocephalus, Chiropotes satanas and Callicebus caligatus. The 14/15 hybridization pattern was present in 13 species, but not in Alouatta sara that showed a 14/15/14 pattern and Aotus nigriceps that showed a 15/14/15/14 pattern. In the majority of the species, the HSA 14 homologue retained synteny for the entire chromosome, whereas the HSA 15 homologue displayed fragmented segments. Within primates, the New World monkeys represent the taxon with the highest variability in chromosome number (2n = 16 to 62. The presence of the HSA 14/15 association in all species and subspecies studied herein confirms that this association is the ancestral condition for platyrrhines and that this association has been retained in most platyrrhines, despite the occurrence of extensive inter- and intrachromosomal rearrangements in this infraorder of Primates.

Synteny of human chromosomes 14 and 15 in the platyrrhines (Primates, Platyrrhini).

Science.gov (United States)

Gifalli-Iughetti, Cristiani; Koiffmann, Célia P

2009-10-01

In order to study the intra- and interspecific variability of the 14/15 association in Platyrrhini, we analyzed 15 species from 13 genera, including species that had not been described yet. The DNA libraries of human chromosomes 14 and 15 were hybridized to metaphases of Alouatta guariba clamitans, A. caraya, A. sara, Ateles paniscus chamek, Lagothrix lagothricha, Brachyteles arachnoides, Saguinus midas midas, Leontopithecus chrysomelas, Callimico goeldii, Callithrix sp., Cebus apella, Aotus nigriceps, Cacajao melanocephalus,Chiropotes satanas and Callicebus caligatus. The 14/15 hybridization pattern was present in 13 species, but not in Alouatta sara that showed a 14/15/14 pattern and Aotus nigriceps that showed a 15/14/15/14 pattern. In the majority of the species, the HSA 14 homologue retained synteny for the entire chromosome, whereas the HSA 15 homologue displayed fragmented segments. Within primates, the New World monkeys represent the taxon with the highest variability in chromosome number (2n = 16 to 62). The presence of the HSA 14/15 association in all species and subspecies studied herein confirms that this association is the ancestral condition for platyrrhines and that this association has been retained in most platyrrhines, despite the occurrence of extensive inter- and intrachromosomal rearrangements in this infraorder of Primates.

Comparison between 30-15 Intermittent Fitness Test and Multistage Field Test on physiological responses in wheelchair basketball players

Directory of Open Access Journals (Sweden)

Thierry eWeissland

2015-12-01

Full Text Available The intermittent nature of wheelchair court sports suggests using a similar protocol to assess repeated shuttles and recovery abilities. This study aimed to compare performances, physiological responses and perceived rating exertion obtained from the continuous multistage field test (MFT and the 30-15 intermittent field test (30-15IFT. Eighteen trained wheelchair basketball players (WBP (WBP: 32.0±5.7y, IWBF classification: 2.9±1.1points performed both incremental field tests in randomized order. Time to exhaustion, maximal rolling velocity (MRV, VO2peak and the peak values of minute ventilation (VEpeak, respiratory frequency (RF and heart rate (HRpeak were measured throughout both tests; peak and net blood lactate (Δ [Lact-] = peak–rest values and perceived rating exertion (RPE values at the end of each exercise. No significant difference in VO2peak, VEpeak and RF was found between both tests. 30-15IFT was shorter (12.4±2.4 vs. 14.9±5.1min, P<0.05 but induced higher values of MRV and Δ [Lact-] compared to MFT (14.2±1.8 vs. 11.1±1.9km•h-1 and 8.3±4.2 vs. 6.9±3.3mmol•L-1, P<0.05. However, HRpeak and RPE values were higher during MFT than 30-15IFT (172.8±14.0 vs. 166.8±13.8bpm and 15.3±3.8 vs.13.8±3.5, respectively, P<0.05. The intermittent shuttles intercepted with rest period occurred during the 30-15IFT could explain a greater anaerobic solicitation. The higher HR and overall RPE values measured at the end of MFT could be explained by its longer duration and a continuous load stress compared to 30-15IFT. In conclusion, 30-15IFT has some advantages over MFT for assess in addition physical fitness and technical performance in WBP.

Physiology and Endocrinology Symposium. Factors controlling puberty in beef heifers

Science.gov (United States)

The Physiology and Endocrinology Symposium on “Factors controlling puberty in beef heifers” was held at the joint annual meeting of the American Dairy Science Association and the American Society of Animal Science in New Orleans, Louisiana, USA, July 10 to 14, 2011. The objective of the symposium w...

Application of 14C to physiological studies of insects

International Nuclear Information System (INIS)

Yamashita, Okitsugu

1977-01-01

The specificity of insects which has been resolved as a result of using tracers such as 14 C etc. and the metabolic ground of vital condition which is not observed in other biotic groups were discussed. As for carbohydrate metabolism, trehalose metabolism, the relation between formation of polyhydric alcohol and quiescence, and energy production system were mentioned. As for lipid metabolism, mobilization of diglyceride among tissues, purification and properties of diglyceride-carrying lipoprotein, and the physiological action of lipoprotein were cited. The specific metabolisms of insects were summarized from the viewpoints of energy production and its distribution mechanism in vivo. (Ichikawa, K.)

15 CFR 14.45 - Cost and price analysis.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Cost and price analysis. 14.45 Section... COMMERCIAL ORGANIZATIONS Post-Award Requirements Procurement Standards § 14.45 Cost and price analysis. Some form of cost or price analysis shall be made and documented in the procurement files in connection with...

Unimodular lattices in dimensions 14 and 15 over the Eisenstein integers

Science.gov (United States)

Abdukhalikov, Kanat; Scharlau, Rudolf

2009-03-01

All indecomposable unimodular hermitian lattices in dimensions 14 and 15 over the ring of integers in mathbb{Q}(sqrt{-3}) are determined. Precisely one lattice in dimension 14 and two lattices in dimension 15 have minimal norm 3.

14 CFR 243.15 - Conflict with foreign laws.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Conflict with foreign laws. 243.15 Section... PROCEEDINGS) ECONOMIC REGULATIONS PASSENGER MANIFEST INFORMATION § 243.15 Conflict with foreign laws. (a) If a... portion of this part is not required because of a conflict with applicable foreign law. [Doc. No. OST-95...

Synthesis of puric bases labelled with carbon 14 and nitrogen 15

International Nuclear Information System (INIS)

Lamorre, Yves

1975-01-01

In this report for graduation in organic chemistry engineering, the author reports the synthesis of adenine 14 C-2 et 14 C-6 by two different chemical ways from two derivatives of imidazole. He has used adenine 14 C-6 to obtain hypoxanthine 14 C-6, and then, by enzymatic processing, uric acid 14 C-6. He reports the study of the production of guanine 14 C-2 by cyclization of silylated derivative of imidazole with the carbon 14 C sulphur. However, a method of complete synthesis of this same compound revealed to be more practical. This complete synthesis way allowed the labelling of guanine in positions 1, 2 and 3 by the 96 per cent isotopic nitrogen. Nitrogen in positions 7 and 9 could have been labelled by the same way from the ethyl cyanoacetate 15 N and from the sodium nitrite 15 N. The study of the mass spectrum of these compounds labelled with nitrogen 15 N allowed most of fragments obtained during this analysis to be identified [fr

The emerging physiological roles of the SLC14A family of urea transporters

Science.gov (United States)

Stewart, Gavin

2011-01-01

In mammals, urea is the main nitrogenous breakdown product of protein catabolism and is produced in the liver. In certain tissues, the movement of urea across cell membranes is specifically mediated by a group of proteins known as the SLC14A family of facilitative urea transporters. These proteins are derived from two distinct genes, UT-A (SLC14A2) and UT-B (SLC14A1). Facilitative urea transporters play an important role in two major physiological processes – urinary concentration and urea nitrogen salvaging. Although UT-A and UT-B transporters both have a similar basic structure and mediate the transport of urea in a facilitative manner, there are a number of significant differences between them. UT-A transporters are mainly found in the kidney, are highly specific for urea, have relatively lower transport rates and are highly regulated at both gene expression and cellular localization levels. In contrast, UT-B transporters are more widespread in their tissue location, transport both urea and water, have a relatively high transport rate, are inhibited by mercurial compounds and currently appear to be less acutely regulated. This review details the fundamental research that has so far been performed to investigate the function and physiological significance of these two types of urea transporters. PMID:21449978

Mechanism of the reactions 14N(d,p)15N and 14N(d,n)15O by Doppler shift line shape method

International Nuclear Information System (INIS)

Abdel-Moneim, A.M.

1976-06-01

In this investigation the total and the differential absolute cross sections of the 14 N(d,p) 15 N reaction leading to excited states at 7.3, 8.3 and 9.05 MeV levels in 15 N and the 14 N(d,n) 15 O reaction leading to the 6.79 MeV level in 15 O, have been studied over the energy range from 0.5 MeV to 3 MeV. Doppler shift line shape method as well as γ-ray yield measurements have been used. The absolute cross sections are determined relative to the known 14 N(p,p) elastic differential cross sections. A comparison with previously determined values for the same reactions at selected energies shows good agreement in angular distribution as well as in absolute values. The total cross section for the d,p reaction shows a general energy dependence which is typical for direct reactions, but with minor contribution from compound nucleus formation at certain energy ranges. For the 14 N(d,n) 15 N reaction, the method applied is unique, since it allows the differential cross section to be studied all the way down to the threshold energy of deuterons at 2 MeV, with a detectorsystem efficiency which is constant over the entire range of neutron energies. The larger part of the energy range that has been investigated is dominated by a resonance at 2.55 π+ 0.05 MeV deuteron energy and a halfwidth depending on the amount of contribution from the direct reaction of the order of 200-400 keV. (JIW)

15 CFR 14.50 - Purpose of reports and records.

Science.gov (United States)

2010-01-01

... financial and program performance and the necessary standard reporting forms. They also set forth record... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Purpose of reports and records. 14.50... COMMERCIAL ORGANIZATIONS Post-Award Requirements Reports and Records § 14.50 Purpose of reports and records...

21 CFR 14.15 - Committees working under a contract with FDA.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Committees working under a contract with FDA. 14.15 Section 14.15 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... committee: (1) The committee shall give public notice of its meetings and agenda, and provide interested...

14,15-EET promotes mitochondrial biogenesis and protects cortical neurons against oxygen/glucose deprivation-induced apoptosis

International Nuclear Information System (INIS)

Wang, Lai; Chen, Man; Yuan, Lin; Xiang, Yuting; Zheng, Ruimao; Zhu, Shigong

2014-01-01

Highlights: • 14,15-EET inhibits OGD-induced apoptosis in cortical neurons. • Mitochondrial biogenesis of cortical neurons is promoted by 14,15-EET. • 14,15-EET preserves mitochondrial function of cortical neurons under OGD. • CREB mediates effect of 14,15-EET on mitochondrial biogenesis and function. - Abstract: 14,15-Epoxyeicosatrienoic acid (14,15-EET), a metabolite of arachidonic acid, is enriched in the brain cortex and exerts protective effect against neuronal apoptosis induced by ischemia/reperfusion. Although apoptosis has been well recognized to be closely associated with mitochondrial biogenesis and function, it is still unclear whether the neuroprotective effect of 14,15-EET is mediated by promotion of mitochondrial biogenesis and function in cortical neurons under the condition of oxygen–glucose deprivation (OGD). In this study, we found that 14,15-EET improved cell viability and inhibited apoptosis of cortical neurons. 14,15-EET significantly increased the mitochondrial mass and the ratio of mitochondrial DNA to nuclear DNA. Key makers of mitochondrial biogenesis, peroxisome proliferator activator receptor gamma-coactivator 1 alpha (PGC-1α), nuclear respiratory factor 1 (NRF-1) and mitochondrial transcription factor A (TFAM), were elevated at both mRNA and protein levels in the cortical neurons treated with 14,15-EET. Moreover, 14,15-EET markedly attenuated the decline of mitochondrial membrane potential, reduced ROS, while increased ATP synthesis. Knockdown of cAMP-response element binding protein (CREB) by siRNA blunted the up-regulation of PGC-1α and NRF-1 stimulated by 14,15-EET, and consequently abolished the neuroprotective effect of 14,15-EET. Our results indicate that 14,15-EET protects neurons from OGD-induced apoptosis by promoting mitochondrial biogenesis and function through CREB mediated activation of PGC-1α and NRF-1

14,15-EET promotes mitochondrial biogenesis and protects cortical neurons against oxygen/glucose deprivation-induced apoptosis

Energy Technology Data Exchange (ETDEWEB)

Wang, Lai; Chen, Man; Yuan, Lin; Xiang, Yuting [Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing (China); Zheng, Ruimao, E-mail: rmzheng@pku.edu.cn [Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing (China); Zhu, Shigong, E-mail: sgzhu@bjmu.edu.cn [Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing (China)

2014-07-18

Highlights: • 14,15-EET inhibits OGD-induced apoptosis in cortical neurons. • Mitochondrial biogenesis of cortical neurons is promoted by 14,15-EET. • 14,15-EET preserves mitochondrial function of cortical neurons under OGD. • CREB mediates effect of 14,15-EET on mitochondrial biogenesis and function. - Abstract: 14,15-Epoxyeicosatrienoic acid (14,15-EET), a metabolite of arachidonic acid, is enriched in the brain cortex and exerts protective effect against neuronal apoptosis induced by ischemia/reperfusion. Although apoptosis has been well recognized to be closely associated with mitochondrial biogenesis and function, it is still unclear whether the neuroprotective effect of 14,15-EET is mediated by promotion of mitochondrial biogenesis and function in cortical neurons under the condition of oxygen–glucose deprivation (OGD). In this study, we found that 14,15-EET improved cell viability and inhibited apoptosis of cortical neurons. 14,15-EET significantly increased the mitochondrial mass and the ratio of mitochondrial DNA to nuclear DNA. Key makers of mitochondrial biogenesis, peroxisome proliferator activator receptor gamma-coactivator 1 alpha (PGC-1α), nuclear respiratory factor 1 (NRF-1) and mitochondrial transcription factor A (TFAM), were elevated at both mRNA and protein levels in the cortical neurons treated with 14,15-EET. Moreover, 14,15-EET markedly attenuated the decline of mitochondrial membrane potential, reduced ROS, while increased ATP synthesis. Knockdown of cAMP-response element binding protein (CREB) by siRNA blunted the up-regulation of PGC-1α and NRF-1 stimulated by 14,15-EET, and consequently abolished the neuroprotective effect of 14,15-EET. Our results indicate that 14,15-EET protects neurons from OGD-induced apoptosis by promoting mitochondrial biogenesis and function through CREB mediated activation of PGC-1α and NRF-1.

Nigerian Journal of Physiological Sciences

African Journals Online (AJOL)

Nigerian Journal of Physiological Sciences (Niger. J. Physiol. Sci.) is a biannual publication of the Physiological Society of Nigeria. It covers diverse areas of research in physiological sciences, publishing reviews in current research areas and original laboratory and clinical research in physiological sciences. Other websites ...

Two structure types based on Si6O15 rings: synthesis and structural and spectroscopic characterisation of Cs1.86K1.14DySi6O15 and Cs1.6K1.4SmSi6O15

International Nuclear Information System (INIS)

Wierzbicka-Wieczorek, Maria; Goeckeritz, Martin; Kolitsch, Uwe; Lenz, Christoph; Giester, Gerald

2015-01-01

The silicate Cs 1.86 K 1.14 DySi 6 O 15 represents a mixed tetrahedral-octahedral framework structure type based on roughly circular Si 6 O 15 rings and isolated DyO 6 octahedra. The silicate Cs 1.6 K 1.4 SmSi 6 O 15 has a layered atomic arrangement built from corrugated Si 6 O 15 layers containing four-, six- and eight-membered rings. The layers are connected by isolated SmO 6 octahedra to form a mixed tetrahedral-octahedral framework. This structure shows a close structural relationship to β-K 3 NdSi 6 O 15 and a less close one to dehydrated elpidite (Na 2 ZrSi 6 O 15 ). In both structures, Cs/K atoms occupy large voids. The silicates were obtained through high-temperature flux syntheses. Their crystal structures have been determined from single-crystal X-ray diffraction data. Cs 1.86 K 1.14 DySi 6 O 15 crystallises in R32 (no. 155) with a = 13.896(2), c = 35.623(7) Aa and V = 5957.2(17) Aa 3 , whereas Cs 1.6 K 1.4 SmSi 6 O 15 crystallises in Cmca (no. 64) with a = 14.474(3), b = 14.718(3), c = 15.231(3) Aa and V = 3244.7(11) Aa 3 . The Dy 3+ and Sm 3+ cations present in the silicates cause PL emission bands in the visible yellow-to-orange spectral range. (Copyright copyright 2015 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

A history of the Federation of European Societies of Plant Physiology FESPP since its foundation in 1978--including notes on events preceding the foundation and following re-naming as the Federation of European Societies of Plant Biology (FESPB) in 2002.

Science.gov (United States)

Lichtenthaler, Hartmut

2004-06-01

After several years of close contacts and extensive discussion between various plant physiologists of different European countries, the Federation of European Societies of Plant Physiology (FESPP) was established in 1978 in Edinburgh. The aim of the FESPP was and remains to promote up-to-date plant physiology research in all European countries and to stimulate scientific cooperation and the exchange of scientists between the different member societies by organizing congresses and workshops as well as editing four (recently five) Federation-affiliated journals. The short History of FESPP presented here covers the preparatory years of the 1970s that led to its actual foundation in 1978, and then its further development up to and following the Federation's reconstitution in 2002 as the Federation of European Societies of Plant Biology (FESPB).

Buffer standards for the physiological pH of N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine (TRICINE) from T = (278.15 to 328.15) K

International Nuclear Information System (INIS)

Roy, Rabindra N.; Roy, Lakshmi N.; Henson, Isaac B.; Stegner, Jessica M.; Dinga, John J.; Summers, Clark E.; Suhrheinrich, Gregory L.; Veliz, Jaime A.; Dieterman, Lauren A.

2012-01-01

Highlights: ► This work reports pH values of TRICINE buffer. ► Liquid junction potential correct is applied. ► These values will be used by clinical and biomedical scientists. ► The pH values lie within 6.8 to 7.5. - Abstract: The pH values of two buffer solutions without NaCl and seven buffer solutions with added NaCl, having ionic strengths (I = 0.16 mol · kg −1 ) similar to those of physiological fluids, have been evaluated at 12 temperatures from T = (278.15 to 328.15) K by way of the extended form of the Debye–Hückel equation of the Bates–Guggenheim convention. The residual liquid junction potentials (δE j ) between the buffer solutions of TRICINE and saturated KCl solution of the calomel electrode at T = (298.15 and 310.15) K have been estimated by measurement with a flowing junction cell. For the buffer solutions with the molality of TRICINE(m 1 ) = 0.06 mol · kg −1 , NaTRICINE(m 2 ) = 0.02 mol · kg −1 , and NaCl(m 3 ) = 0.14 mol · kg −1 , the pH values at T = 310.15 K obtained from the extended Debye–Hückel equation and the inclusion of the liquid junction correction are 7.342 and 7.342, respectively. These are in excellent agreement. The zwitterionic buffer TRICINE is recommended as a secondary pH standard in the region for clinical application.

Synthesis of [14α, 15α-3H]-norgestrel

International Nuclear Information System (INIS)

Wagner, H.

1988-01-01

The preparation of the well-known gestogen norgestrel in a tritium labelled form is described. Starting material was 18-methyl-3-methoxy-estra-1,3,5(10),8,14-pentaen-17β-o1 acetate. In a four step synthesis 17α-ethinyl-17β-hydroxy-18-methyl-[14α,15α- 3 H]-estr-4-en-3-one was obtained with a specific activity of 52 Ci/mmol and a radiochemical purity > 99%. (author)

The emergence of Applied Physiology within the discipline of Physiology.

Science.gov (United States)

Tipton, Charles M

2016-08-01

Despite the availability and utilization of the physiology textbooks authored by Albrecht von Haller during the 18th century that heralded the modern age of physiology, not all physicians or physiologists were satisfied with its presentation, contents, or application to medicine. Initial reasons were fundamental disagreements between the "mechanists," represented by Boerhaave, Robinson, and von Haller, and the "vitalists," represented by the faculty and graduates of the Montpellier School of Medicine in France, notably, Bordeu and Barthez. Subsequently, objections originated from Europe, United Kingdom, and the United States in publications that focused not only on the teaching of physiology to medical and secondary students, but on the specific applications of the content of physiology to medicine, health, hygiene, pathology, and chronic diseases. At the turn of the 20th century, texts began to appear with applied physiology in their titles and in 1926, physician Samson Wright published a textbook entitled Applied Physiology that was intended for both medical students and the medical profession. Eleven years later, physicians Best and Taylor published The Physiological Basis of Medical Practice: A University of Toronto Texbook in Applied Physiology Although both sets of authors defined the connection between applied physiology and physiology, they failed to define the areas of physiology that were included within applied physiology. This was accomplished by the American Physiological Society (APS) Publications Committee in 1948 with the publication of the Journal of Appplied Physiology, that stated the word "applied" would broadly denote human physiology whereas the terms stress and environment would broadly include work, exercise, plus industrial, climatic and social factors. NIH established a study section (SS) devoted to applied physiology in 1964 which remained active until 2001 when it became amalgamated into other SSs. Before the end of the 20th century when

14 CFR 385.15 - Authority of the Deputy General Counsel.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Authority of the Deputy General Counsel. 385.15 Section 385.15 Aeronautics and Space OFFICE OF THE SECRETARY, DEPARTMENT OF TRANSPORTATION... affiliated with, any person subject to regulation under Titles IV or X of the Act, through issuance of an...

14,15-EET promotes mitochondrial biogenesis and protects cortical neurons against oxygen/glucose deprivation-induced apoptosis.

Science.gov (United States)

Wang, Lai; Chen, Man; Yuan, Lin; Xiang, Yuting; Zheng, Ruimao; Zhu, Shigong

2014-07-18

14,15-Epoxyeicosatrienoic acid (14,15-EET), a metabolite of arachidonic acid, is enriched in the brain cortex and exerts protective effect against neuronal apoptosis induced by ischemia/reperfusion. Although apoptosis has been well recognized to be closely associated with mitochondrial biogenesis and function, it is still unclear whether the neuroprotective effect of 14,15-EET is mediated by promotion of mitochondrial biogenesis and function in cortical neurons under the condition of oxygen-glucose deprivation (OGD). In this study, we found that 14,15-EET improved cell viability and inhibited apoptosis of cortical neurons. 14,15-EET significantly increased the mitochondrial mass and the ratio of mitochondrial DNA to nuclear DNA. Key makers of mitochondrial biogenesis, peroxisome proliferator activator receptor gamma-coactivator 1 alpha (PGC-1α), nuclear respiratory factor 1 (NRF-1) and mitochondrial transcription factor A (TFAM), were elevated at both mRNA and protein levels in the cortical neurons treated with 14,15-EET. Moreover, 14,15-EET markedly attenuated the decline of mitochondrial membrane potential, reduced ROS, while increased ATP synthesis. Knockdown of cAMP-response element binding protein (CREB) by siRNA blunted the up-regulation of PGC-1α and NRF-1 stimulated by 14,15-EET, and consequently abolished the neuroprotective effect of 14,15-EET. Our results indicate that 14,15-EET protects neurons from OGD-induced apoptosis by promoting mitochondrial biogenesis and function through CREB mediated activation of PGC-1α and NRF-1. Copyright © 2014 Elsevier Inc. All rights reserved.

Antibody Engineering & Therapeutics 2016: The Antibody Society's annual meeting, December 11-15, 2016, San Diego, CA.

Science.gov (United States)

Larrick, James W; Alfenito, Mark R; Scott, Jamie K; Parren, Paul W H I; Burton, Dennis R; Bradbury, Andrew R M; Lemere, Cynthia A; Messer, Anne; Huston, James S; Carter, Paul J; Veldman, Trudi; Chester, Kerry A; Schuurman, Janine; Adams, Gregory P; Reichert, Janice M

Antibody Engineering & Therapeutics, the largest meeting devoted to antibody science and technology and the annual meeting of The Antibody Society, will be held in San Diego, CA on December 11-15, 2016. Each of 14 sessions will include six presentations by leading industry and academic experts. In this meeting preview, the session chairs discuss the relevance of their topics to current and future antibody therapeutics development. Session topics include bispecifics and designer polyclonal antibodies; antibodies for neurodegenerative diseases; the interface between passive and active immunotherapy; antibodies for non-cancer indications; novel antibody display, selection and screening technologies; novel checkpoint modulators / immuno-oncology; engineering antibodies for T-cell therapy; novel engineering strategies to enhance antibody functions; and the biological Impact of Fc receptor engagement. The meeting will open with keynote speakers Dennis R. Burton (The Scripps Research Institute), who will review progress toward a neutralizing antibody-based HIV vaccine; Olivera J. Finn, (University of Pittsburgh School of Medicine), who will discuss prophylactic cancer vaccines as a source of therapeutic antibodies; and Paul Richardson (Dana-Farber Cancer Institute), who will provide a clinical update on daratumumab for multiple myeloma. In a featured presentation, a representative of the World Health Organization's INN expert group will provide a perspective on antibody naming. "Antibodies to watch in 2017" and progress on The Antibody Society's 2016 initiatives will be presented during the Society's special session. In addition, two pre-conference workshops covering ways to accelerate antibody drugs to the clinic and the applications of next-generation sequencing in antibody discovery and engineering will be held on Sunday December 11, 2016.

Neutronic evaluation of annular fuel rods to assemblies 13 x 13, 14 x 14 and 15 x 15

International Nuclear Information System (INIS)

Silva, Raphael H.M.; Ramos, Mario C.; Velasquez, Carlos E.; Silva, Clarysson A.M. da; Pereira, Cláubia; Costa, Antonella L.

2017-01-01

Research and development in nuclear reactor field has been proposed a new concept of fuel rod such as annular shape. The design of the annular fuel rods allows the coolant flow through the inner and outer side of it. Such project was proposed as an alternative to the traditional fuel rods used in LWR reactors. This new geometry allows an increase in power density in the reactor core with greater heat transfer from the fuel to the coolant which reduces the temperature in central region of the rod, in which a better configuration and dimension of fuel elements are aimed due to improvement of cooling in possible replacement of PWR traditional rods for annular rods. The aim of this work is to evaluate the neutronic parameters of fuel element with annular fuel rods where three configurations were studied: 13 x 13, 14 x 14 and 15 x 15. The goal is compare the neutronic between the advanced and the standard fuel assembly 16 x 16. In these studies, the external dimension and the moderator to fuel volume ratio (V M /V F ) of standard 16 x 16 is the same in all annular fuels assemblies. The MCNPX 2.6.0 (Monte Carlo N-Particle eXtended – version 2.6.0) code was used in all simulations. After all procedures, the annular fuel assemblies 13 have obtained greater neutronics parameters and were selected to more neutronics simulations. (author)

Neutronic evaluation of annular fuel rods to assemblies 13 x 13, 14 x 14 and 15 x 15

Energy Technology Data Exchange (ETDEWEB)

Silva, Raphael H.M.; Ramos, Mario C.; Velasquez, Carlos E.; Silva, Clarysson A.M. da; Pereira, Cláubia; Costa, Antonella L., E-mail: rapha.galo@hotmail.com, E-mail: marc5663@gmail.com, E-mail: carlosvelcab@hotmail.com, E-mail: clarysson@nuclear.ufmg.br, E-mail: claubia@nuclear.ufmg.br, E-mail: antonella@nuclear.ufmg.br [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil). Departamento de Engenharia Nuclear

2017-07-01

Research and development in nuclear reactor field has been proposed a new concept of fuel rod such as annular shape. The design of the annular fuel rods allows the coolant flow through the inner and outer side of it. Such project was proposed as an alternative to the traditional fuel rods used in LWR reactors. This new geometry allows an increase in power density in the reactor core with greater heat transfer from the fuel to the coolant which reduces the temperature in central region of the rod, in which a better configuration and dimension of fuel elements are aimed due to improvement of cooling in possible replacement of PWR traditional rods for annular rods. The aim of this work is to evaluate the neutronic parameters of fuel element with annular fuel rods where three configurations were studied: 13 x 13, 14 x 14 and 15 x 15. The goal is compare the neutronic between the advanced and the standard fuel assembly 16 x 16. In these studies, the external dimension and the moderator to fuel volume ratio (V{sub M}/V{sub F}) of standard 16 x 16 is the same in all annular fuels assemblies. The MCNPX 2.6.0 (Monte Carlo N-Particle eXtended – version 2.6.0) code was used in all simulations. After all procedures, the annular fuel assemblies 13 have obtained greater neutronics parameters and were selected to more neutronics simulations. (author)

15 CFR 14.21 - Standards for financial management systems.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Standards for financial management...-PROFIT, AND COMMERCIAL ORGANIZATIONS Post-Award Requirements Financial and Program Management § 14.21 Standards for financial management systems. (a) The Grants Officer shall require recipients to relate...

A prospective observational study comparing a physiological scoring system with time-based discharge criteria in pediatric ambulatory surgical patients.

Science.gov (United States)

Armstrong, James; Forrest, Helen; Crawford, Mark W

2015-10-01

Discharge criteria based on physiological scoring systems can be used in the postanesthesia care unit (PACU) to fast-track patients after ambulatory surgery; however, studies comparing physiological scoring systems with traditional time-based discharge criteria are lacking. The purpose of this study was to compare PACU discharge readiness times using physiological vs time-based discharge criteria in pediatric ambulatory surgical patients. We recorded physiological observations from consecutive American Society of Anesthesiologists physical status I-III patients aged 1-18 yr who were admitted to the PACU after undergoing ambulatory surgery in a tertiary academic pediatric hospital. The physiological score was a combination of the Aldrete and Chung systems. Scores were recorded every 15 min starting upon arrival in the PACU. Patients were considered fit for discharge once they attained a score ≥12 (maximum score, 14), provided no score was zero, with the time to achieve a score ≥12 defining the criteria-based discharge (CBD) time. Patients were discharged from the PACU when both the CBD and the existing time-based discharge (TBD) criteria were met. The CBD and TBD data were compared using Kaplan-Meier and log-rank analysis. Observations from 506 children are presented. Median (interquartile range [IQR]) age was 5.5 [2.8-9.9] yr. Median [IQR] CBD and TBD PACU discharge readiness times were 30 [15-45] min and 60 [45-60] min, respectively. Analysis of Kaplan-Meier curves indicated a significant difference in discharge times using the different criteria (hazard ratio, 5.43; 95% confidence interval, 4.51 to 6.53; P < 0.001). All patients were discharged home without incident. This prospective study suggests that discharge decisions based on physiological criteria have the potential for significantly speeding the transit of children through the PACU, thereby enhancing PACU efficiency and resource utilization.

46 CFR 105.10-15 - Flammable liquid.

Science.gov (United States)

2010-10-01

... FISHING VESSELS DISPENSING PETROLEUM PRODUCTS Definition of Terms Used in This Part § 105.10-15 Flammable... vapor pressure of 14 pounds or more. 1 American Society of Testing Materials Standard D 323...

Research and Development Program in Reactor Diagnostics and Monitoring with Neutron Noise Methods. Stages 14 and 15

International Nuclear Information System (INIS)

Pazsit, Imre; Wihlstrand, Gustav; Tambouratzis, Tatiana; Jonsson, Anders; Dahl, Berit

2009-12-01

This report constitutes Stages 14 and 15 of a long-term research and development program concerning the development of diagnostics and monitoring methods for nuclear reactors. Stage 14 was a full one-year project, whereas Stage 15 consisted of a half-year project. The program executed in Stages 14 and 15 consists of the following three parts: - Study of criticality, neutron kinetics and neutron noise in molten salt reactors (MSR) (Stages 14 and 15); - An overview and introduction to fuzzy logics (Stage 14), and an application to two-phase flow identification (Stage 15) - Preparations for and execution of an IAEA-ICTP workshop on Neutron fluctuations, reactor noise and their applications in nuclear reactors (Stage 14)

Research and Development Program in Reactor Diagnostics and Monitoring with Neutron Noise Methods. Stages 14 and 15

Energy Technology Data Exchange (ETDEWEB)

Pazsit, Imre; Wihlstrand, Gustav; Tambouratzis, Tatiana; Jonsson, Anders; Dahl, Berit (Chalmers Univ. of Technology, Dept. of Nuclear Engineering, SE-412 96 Goeteborg (Sweden))

2009-12-15

This report constitutes Stages 14 and 15 of a long-term research and development program concerning the development of diagnostics and monitoring methods for nuclear reactors. Stage 14 was a full one-year project, whereas Stage 15 consisted of a half-year project. The program executed in Stages 14 and 15 consists of the following three parts: - Study of criticality, neutron kinetics and neutron noise in molten salt reactors (MSR) (Stages 14 and 15); - An overview and introduction to fuzzy logics (Stage 14), and an application to two-phase flow identification (Stage 15) - Preparations for and execution of an IAEA-ICTP workshop on Neutron fluctuations, reactor noise and their applications in nuclear reactors (Stage 14)

ISVEE 14 Yucatan 2015 14th Symposium of the International Society for Veterinary Epidemiology and Economics.

Science.gov (United States)

de Anda, Jorge Hernández

2017-02-01

The 14th Symposium of the International Society for Veterinary Epidemiology and Economics (ISVEE 14) was held in Merida, Yucatan, Mexico during 3-7 November. 2015. The purpose of ISVEE 14 Yucatan 2015 was to provide a global forum for graduate students, postdoctoral fellows, junior and senior investigators, as well as health policymakers to exchange information that can advance the fields of veterinary epidemiology and economics, and other disciplines in the health and social sciences. The main theme of ISVEE 14 was Planning Our Future. Human population growth is predicted to increase nearly 50% to 11 billion by 2050, and climate change and changing land use can have an impact on local and global food systems, interactions among humans, wildlife and domestic animals, as well as local, regional, and global public health alerts. How can we help our systems of education, research, and public policy adapt? Are new veterinary graduates and epidemiology practitioners prepared to become active protagonists in the solution of health issues that affect humans and animal populations in a changing environment? What innovative research is needed to understand and enhance the food systems of the future? What are the expected roles or contributions of veterinarians or epidemiology practitioners on future climate change, food systems, and health? Is our profession or discipline leading One Health initiatives? Are there current or new models that make national veterinary services more efficacious and efficient for disease control and eradication? To help us answer these questions, the organizing committee of ISVEE 14 invited five distinguished keynote speakers to share their vision and innovative ideas on education, technological developments, research, and public policy of our future with a concentration in the following five areas: (i) One Health (Jonna Mazet), (ii) climate change (Bernard Bett), (iii) animal health economics (Jonathan Rushton), (iv) national veterinary services

15 CFR 14.35 - Supplies and other expendable property.

Science.gov (United States)

2010-01-01

... recipient upon acquisition. If there is a residual inventory of supplies exceeding $5000 in total aggregate... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Supplies and other expendable property...-PROFIT, AND COMMERCIAL ORGANIZATIONS Post-Award Requirements Property Standards § 14.35 Supplies and...

Nigerian Journal of Physiological Sciences: Editorial Policies

African Journals Online (AJOL)

Focus and Scope. Nigerian Journal of Physiological Sciences (Niger. J. Physiol. Sci.) is a biannual publication of the Physiological Society of Nigeria. It covers diverse areas of research in physiological sciences, publishing reviews in current research areas and original laboratory and clinical research in physiological ...

Fate of 15N and 14C from labelled plant material

DEFF Research Database (Denmark)

Rasmussen, Jim; Gjettermann, Birgitte; Eriksen, Jørgen

2008-01-01

strength of labelled plant residues in dissolved inorganic N (DIN) and dissolved organic N (DON) in pore water from the plough layer, and (ii) the plant uptake of organically bound N. Litterbags containing 14C- and 15N-labelled ryegrass or clover roots or leaves were inserted into the sward of a ryegrass......–clover mixture in early spring. The fate of the released 14C and 15N was monitored in harvested biomass, roots, soil, and pore water percolating from the plough layer. No evidence of plant uptake of dual-labelled organic compounds from the dual-labelled residues could be observed. N in pore water from the plough...

15 CFR 908.14 - Business to be transacted in writing.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Business to be transacted in writing... MAINTAINING RECORDS AND SUBMITTING REPORTS ON WEATHER MODIFICATION ACTIVITIES § 908.14 Business to be transacted in writing. All business transacted with the National Oceanic and Atmospheric Administration with...

Synthesis of 1,5-Diaryl-1,4-pentadien-3-one Amidinohydrazone Hydrochloride Under Ultrasound Irradiation

Directory of Open Access Journals (Sweden)

Chao Du

2012-01-01

Full Text Available Synthesis of 1,5-diaryl-1,4-pentadien-3-one amidinohydrazone hydrochloride via the condensation of 1,5-diaryl-1,4-pentadien-3-one and aminoguanidine hydrochloride catalyzed by hydrochloric acid was carried out in 80-94% yield at 35-37°C within 1.5 h under ultrasound irradiation. Compared to the classical method, the advantages of this method are milder conditions, shorter reaction time and higher yield.

Lyfstraf en martelaarskap in Augustinus se Confessiones 1.9.14-15

African Journals Online (AJOL)

p1243322

14-15. The article examines a passage from the Confessions in which two instances of violence are introduced. In the course of his autobiographical narration Augustine describes how, as a school boy, he feared corporal ...

Comparison Between 30-15 Intermittent Fitness Test and Multistage Field Test on Physiological Responses in Wheelchair Basketball Players

OpenAIRE

Weissland, Thierry; Faupin, Arnaud; Borel, Benoit; Leprêtre, Pierre-Marie

2015-01-01

The intermittent nature of wheelchair court sports suggests using a similar protocol to assess repeated shuttles and recovery abilities. This study aimed to compare performances, physiological responses and perceived rating exertion obtained from the continuous multistage field test (MFT) and the 30-15 intermittent field test (30-15IFT). Eighteen trained wheelchair basketball players (WBP) (WBP: 32.0 ? 5.7 y, IWBF classification: 2.9 ? 1.1 points) performed both incremental field tests in ran...

15 CFR 19.14 - How will Commerce entities report Commerce debts to credit bureaus?

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false How will Commerce entities report Commerce debts to credit bureaus? 19.14 Section 19.14 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect Commerce Debts § 19.14 How will Commerce entities...

Effectiveness of 14-15 years old tennis players’ competition functioning considering correction of their psychological fitness

Directory of Open Access Journals (Sweden)

T.B. Makuts

2015-10-01

Full Text Available Purpose: to determination influence of individualized psychological training on effectiveness of 14-15 years old tennis players’ competition functioning. Material: in the research 24 tennis players of 14-15 years’ age participated. Individualized psychological training consisted of 15 sessions of total duration of 1.5 months. Results: We substantiated necessity of individualized approach to tennis players’ psychological training. Individual psychological profiles for tennis players, which determined content of psychological training and their selection, were worked out. Informative indicators for assessment of 14-15 years old tennis players’ competition functioning were determined: 1 percentage of won and lost scores at the account of own actions; 2 integral criteria of tennis players’ competition functioning assessment (coefficient of stability and effectiveness; complex indicator of efficiency. Conclusions: it is recommended to consider individual potentials and bents of sportsmen in the course of psychological training.

Espectro infrarrojo de [zn(mh34](re042 com substituicion isotópica 14n/15n

Directory of Open Access Journals (Sweden)

Claudio Téllez

1983-11-01

Full Text Available The infrared spectra of [Zn(15NH34] (Re042 and the isotopoc shift 14N/15N (Zn-n for the metal-ligand band, is reportedInforma-se o espectro infravermelho do complexo de Zn(II, [Zn(15NH341(Re04 e o deslocamento isotópico 14N/15N, para a banda metal - ligante v(Zn-N.

Physiology of man and animals in the Tenth Five-Year Plan: Proceedings of the Thirteenth Congress of the I. P. Pavlov All-Union Physiological Society

Science.gov (United States)

Lange, K. A.

1980-01-01

Research in the field of animal and human physiology is reviewed. The following topics on problems of physiological science and related fields of knowledge are discussed: neurophysiology and higher nervous activity, physiology of sensory systems, physiology of visceral systems, evolutionary and ecological physiology, physiological cybernetics, computer application in physiology, information support of physiological research, history and theory of development of physiology. Also discussed were: artificial intelligence, physiological problems of reflex therapy, correlation of structure and function of the brain, adaptation and activity, microcirculation, and physiological studies in nerve and mental diseases.

Using stimulation of the diving reflex in humans to teach integrative physiology.

Science.gov (United States)

Choate, Julia K; Denton, Kate M; Evans, Roger G; Hodgson, Yvonne

2014-12-01

During underwater submersion, the body responds by conserving O2 and prioritizing blood flow to the brain and heart. These physiological adjustments, which involve the nervous, cardiovascular, and respiratory systems, are known as the diving response and provide an ideal example of integrative physiology. The diving reflex can be stimulated in the practical laboratory setting using breath holding and facial immersion in water. Our undergraduate physiology students complete a laboratory class in which they investigate the effects of stimulating the diving reflex on cardiovascular variables, which are recorded and calculated with a Finapres finger cuff. These variables include heart rate, cardiac output, stroke volume, total peripheral resistance, and arterial pressures (mean, diastolic, and systolic). Components of the diving reflex are stimulated by 1) facial immersion in cold water (15°C), 2) breathing with a snorkel in cold water (15°C), 3) facial immersion in warm water (30°C), and 4) breath holding in air. Statistical analysis of the data generated for each of these four maneuvers allows the students to consider the factors that contribute to the diving response, such as the temperature of the water and the location of the sensory receptors that initiate the response. In addition to providing specific details about the equipment, protocols, and learning outcomes, this report describes how we assess this practical exercise and summarizes some common student misunderstandings of the essential physiological concepts underlying the diving response. Copyright © 2014 The American Physiological Society.

Synthesis of the new boron hydride nido-undecaborane(15), B11H15, and the x-ray structure of its conjugate base tetradecahydroundecaborate(1-), [B11H14]-

International Nuclear Information System (INIS)

Getman, T.D.; Krause, J.A.; Shore, S.G.

1988-01-01

The preparation of nido-undecaborane, B 11 H 15 , from the protonation of K[B 11 H 14 ] and the subsequent deprotonation of B 11 H 15 by P(CH 3 ) 3 to give [P(CH 3 ) 3 H][B 11 H 14 ] is described. The structure of [P(CH 3 ) 3 H][B 11 H 14 ] has been determined from single-crystal x-ray data. The spectral data indicate that the boron framework of B 11 H 15 is similar to that of [B 11 H 14 ] - . 11 references, 1 figure

Preschool Psychopathology Reported by Parents in 23 Societies: Testing the Seven-Syndrome Model of the Child Behavior Checklist for Ages 1.5–5

Science.gov (United States)

Ivanova, Masha Y.; Achenbach, Thomas M.; Rescorla, Leslie A.; Harder, Valerie S.; Ang, Rebecca P.; Bilenberg, Niels; Bjarnadottir, Gudrun; Capron, Christiane; De Pauw, Sarah S.W.; Dias, Pedro; Dobrean, Anca; Doepfner, Manfred; Duyme, Michele; Eapen, Valsamma; Erol, Nese; Esmaeili, Elaheh Mohammad; Ezpeleta, Lourdes; Frigerio, Alessandra; Gonçalves, Miguel M.; Gudmundsson, Halldor S.; Jeng, Suh-Fang; Jetishi, Pranvera; Jusiene, Roma; Kim, Young-Ah; Kristensen, Solvejg; Lecannelier, Felipe; Leung, Patrick W.L.; Liu, Jianghong; Montirosso, Rosario; Oh, Kyung Ja; Plueck, Julia; Pomalima, Rolando; Shahini, Mimoza; Silva, Jaime R.; Simsek, Zynep; Sourander, Andre; Valverde, Jose; Van Leeuwen, Karla G.; Woo, Bernardine S.C.; Wu, Yen-Tzu; Zubrick, Stephen R.; Verhulst, Frank C.

2014-01-01

Objective To test the fit of a seven-syndrome model to ratings of preschoolers' problems by parents in very diverse societies. Method Parents of 19,106 children 18 to 71 months of age from 23 societies in Asia, Australasia, Europe, the Middle East, and South America completed the Child Behavior Checklist for Ages 1.5–5 (CBCL/1.5–5). Confirmatory factor analyses were used to test the seven-syndrome model separately for each society. Results The primary model fit index, the root mean square error of approximation (RMSEA), indicated acceptable to good fit for each society. Although a six-syndrome model combining the Emotionally Reactive and Anxious/Depressed syndromes also fit the data for nine societies, it fit less well than the seven-syndrome model for seven of the nine societies. Other fit indices yielded less consistent results than the RMSEA. Conclusions The seven-syndrome model provides one way to capture patterns of children's problems that are manifested in ratings by parents from many societies. Clinicians working with preschoolers from these societies can thus assess and describe parents' ratings of behavioral, emotional, and social problems in terms of the seven syndromes. The results illustrate possibilities for culture–general taxonomic constructs of preschool psychopathology. Problems not captured by the CBCL/1.5–5 may form additional syndromes, and other syndrome models may also fit the data. PMID:21093771

Lyfstraf en martelaarskap in Augustinus se Confessiones 1.9.14-15 ...

African Journals Online (AJOL)

Corporal punishment and martyrdom in Augustine's Confessiones 1.9.14-15. The article examines a passage from the Confessions in which two instances of violence are introduced. In the course of his autobiographical narration Augustine describes how, as a school boy, he feared corporal punishment and compares it to ...

Homer Wheelon, M.D., physiologist, artist, and poet: origins of the tailpieces in journals of the American Physiological Society.

Science.gov (United States)

Schramm, Lawrence P; Schramm, Diana C; Jackson, F Wilson

2006-12-01

Since 1953, illustrations have been inserted as "tailpieces" at the ends of articles in The American Journal of Physiology and The Journal of Applied Physiology. The drawings were made by Homer Wheelon, a member of the American Physiological Society from 1919 until his death in 1960. Forty-five years after his death, Wheelon is unknown, but he contributed 32 publications to the medical literature and trained J. Earl Thomas, an important 20th century gastrointestinal physiologist. Wheelon was born into poverty in 1883 to itinerant Methodist preachers, circumstances that guided his education and career choices. Throughout his life, Wheelon exhibited a fondness and talent for art and photography and an unusual breadth of intellectual interests and knowledge. Wheelon received a bachelor's degree from the University of Washington, then studied at the University of Oregon, Northwestern University, and St. Louis University. Earning his M.D. from St. Louis University and assuming a faculty position there, Wheelon and his graduate student, Thomas, conducted widely recognized gastrointestinal research. Returning to Seattle in 1921, Wheelon became a highly respected physician and hospital administrator, but he also found time to indulge his interest in visual art and poetry. In 1933, inspired by observing a rabbit being used in a pregnancy test, Wheelon began to write and illustrate an epic, 322-page poem, Rabbit No. 202, illustrations from which became the journals' tailpieces. The present study traces Wheelon's personal life and scientific career in an attempt to understand this complex man and the origins of his unusual poem and its drawings.

Synthesis of substituted 1,4-diazepines and 1,5-benzodiazepines using an efficient heteropolyacid-catalyzed procedure.

Science.gov (United States)

Kaoua, Rachedine; Bennamane, Norah; Bakhta, Saliha; Benadji, Sihame; Rabia, Cherifa; Nedjar-Kolli, Bellara

2010-12-28

An efficient and improved procedure for the synthesis of 1,4-diazepine and 1,5-benzodiazepine derivatives via the reaction of ketimine intermediates with aldehydes in the presence of Keggin-type heteropolyacids (HPAs) was developed. High yields and short reaction times were obtained for both electron-releasing and electron-withdrawing substituted 1,4-diazepine  and 1,5-benzodiazepines derivatives.

Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure

Directory of Open Access Journals (Sweden)

Sihame Benadji

2010-12-01

Full Text Available An efficient and improved procedure for the synthesis of 1,4-diazepine and 1,5-benzodiazepine derivatives via the reaction of ketimine intermediates with aldehydes in the presence of Keggin-type heteropolyacids (HPAs was developed. High yields and short reaction times were obtained for both electron-releasing and electron-withdrawing substituted 1,4-diazepine  and 1,5-benzodiazepines derivatives.

Simultaneous determination of 14N and 15N isotopes in opium by proton induced γ-ray emission technique

International Nuclear Information System (INIS)

Pritty Rao; Reddy, G.L.N.; Vikram Kumar, S.; Ramana, J.V.; Raju, V.S.; Sanjiv Kumar

2012-01-01

The paper describes the simultaneous determination of 14 N and 15 N isotopes in opium by proton induced γ-ray emission (PIGE) technique. The isotopic ratio of 14 N and 15 N is a useful parameter for assigning provenance of (seized) illicit drugs. The measurement, non-destructive in nature, is performed on pellets made up of opium powders and is based on the prompt detection of 2.313 and 4.4 MeV γ-rays emanating from 14 N(p,p'γ) 14 N and 15 N(p,αγ) 12 C nuclear reactions respectively, induced simultaneously by 3.6-3.8 MeV proton beam. Positive as well as negative deviations from the natural isotopic abundance (99.63:0.37) were observed in the samples. The precision of the measurements is about 4%. The methodology provides an easy and rapid approach to determine the isotopic ratio of 14 N and 15 N and has been used for the first time in the analysis of opium. (author)

Cardiorespiratory physiological phenotypic plasticity in developing air-breathing anabantid fishes (Betta splendens and Trichopodus trichopterus).

Science.gov (United States)

Mendez-Sanchez, Jose F; Burggren, Warren W

2017-08-01

Developmental plasticity of cardiorespiratory physiology in response to chronic hypoxia is poorly understood in larval fishes, especially larval air-breathing fishes, which eventually in their development can at least partially "escape" hypoxia through air breathing. Whether the development air breathing makes these larval fishes less or more developmentally plastic than strictly water breathing larval fishes remains unknown. Consequently, developmental plasticity of cardiorespiratory physiology was determined in two air-breathing anabantid fishes ( Betta splendens and Trichopodus trichopterus ). Larvae of both species experienced an hypoxic exposure that mimicked their natural environmental conditions, namely chronic nocturnal hypoxia (12 h at 17 kPa or 14 kPa), with a daily return to diurnal normoxia. Chronic hypoxic exposures were made from hatching through 35 days postfertilization, and opercular and heart rates measured as development progressed. Opercular and heart rates in normoxia were not affected by chronic nocturnal hypoxic. However, routine oxygen consumption M˙O2 (~4  μ mol·O 2 /g per hour in normoxia in larval Betta ) was significantly elevated by chronic nocturnal hypoxia at 17 kPa but not by more severe (14 kPa) nocturnal hypoxia. Routine M˙O2 in Trichopodus (6-7  μ mol·O 2 /g per hour), significantly higher than in Betta , was unaffected by either level of chronic hypoxia. P Crit , the PO 2 at which M˙O2 decreases as ambient PO 2 falls, was measured at 35 dpf, and decreased with increasing chronic hypoxia in Betta , indicating a large, relatively plastic hypoxic tolerance. However, in contrast, P Crit in Trichopodus increased as rearing conditions grew more hypoxic, suggesting that hypoxic acclimation led to lowered hypoxic resistance. Species-specific differences in larval physiological developmental plasticity thus emerge between the relatively closely related Betta and Trichopodus Hypoxic rearing increased hypoxic tolerance in

Forty years of European Society for Muscle Research

Directory of Open Access Journals (Sweden)

Marcus C. Schaub

2010-09-01

Full Text Available The European Muscle Club was founded 1971 and since 1972 yearly muscle conferences were held in turn in different European countries. Regular scientific meetings in the field of muscle research did not exist before. The name of the Muscle Club was 1988 changed to European Society for Muscle Research (ESMR. The yearly meetings usually attract 200-300 participants. The 39th meeting will be held 11-15 Sept. 2010 in Abano Terme near Padova, and the 40th meeting 14-18 Sept. 2011 in Berlin. Since 1980 the meeting reports and abstracts are regularly published in the Journal of Muscle Research and Cell Motility (JMRCM. The history of the society and the muscle scientists involved with it will be outlined.

Academic Training Lectures | Representing Scientific Communities by Data Visualization | 14-15 March

CERN Multimedia

2016-01-01

Please note that the next series of Academic Training Lectures will take place from 14 to 15 March 2016 and will be given by Dario Rodighiero (EPFL, Lausanne, Switzerland).   Representing Scientific Communities by Data Visualisation (1/2)​ Monday, 14 March 2016 from 11 a.m. to 12 p.m. https://indico.cern.ch/event/465533/ Representing Scientific Communities by Data Visualisation (2/2)​ Tuesday, 15 March 2016 from 11 a.m. to 12 p.m. https://indico.cern.ch/event/465534/ at CERN, IT Amphitheatre (31-3-004)  Description: These lectures present research that investigates the representation of communities, and the way to foster their understanding by different audiences. Communities are complex multidimensional entities intrinsically difficult to represent synthetically. The way to represent them is likely to differ depending on the audience considered: governi...

DBMS for index book for the Journal of the Korean Radiological Society

International Nuclear Information System (INIS)

Choi, Hyung Sik; Suh, Jung Ho

1990-01-01

Medical research and writing for publication are based on a collection and arrangement of related literatures. The authors developed DBMS (Database Management System) for index book of the Journal of the Korean Radiological Society. The computer program was generated in R base system V language (Microrim) using the IBM compatible AT. Two tables had fundamental data with about 1.4 megabytes. Four tables were derived from them to produce seven printing files, the sum memory of which was about 1.5 megabytes. Many radiologists may utilize the database to pursue the information of these published in the Journal of the Korean Radiological Society. This DBMS is useful publishing the index book and can be applied by other medical societies

14 CFR 121.15 - Carriage of narcotic drugs, marihuana, and depressant or stimulant drugs or substances.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Carriage of narcotic drugs, marihuana, and depressant or stimulant drugs or substances. 121.15 Section 121.15 Aeronautics and Space FEDERAL AVIATION....15 Carriage of narcotic drugs, marihuana, and depressant or stimulant drugs or substances. If a...

1,5-Bis (2-Hydroxyphenyl)Pent-1,4-Diene-3-One: A Lead ...

African Journals Online (AJOL)

NJD

occurring chalcone nucleus to design effective antibacterial agents. The present investigation established 1,5-bis(2-hydroxyphenyl)pent-1,4-diene-3-one (1c) as a lead compound with potential against a panel of pathogenic bacterial strains, ...

14 CFR 193.15 - What FAA officials exercise the authority of the Administrator under this part?

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false What FAA officials exercise the authority of the Administrator under this part? 193.15 Section 193.15 Aeronautics and Space FEDERAL AVIATION... SUBMITTED INFORMATION § 193.15 What FAA officials exercise the authority of the Administrator under this...

ORTHO-TO-PARA ABUNDANCE RATIO (OPR) OF AMMONIA IN 15 COMETS: OPRs OF AMMONIA VERSUS 14N/15N RATIOS IN CN

International Nuclear Information System (INIS)

Shinnaka, Yoshiharu; Kawakita, Hideyo; Kobayashi, Hitomi; Jehin, Emmanuel; Manfroid, Jean; Hutsemekers, Damien; Arpigny, Claude

2011-01-01

The ortho-to-para abundance ratio (OPR) of cometary molecules is considered to be one of the primordial characteristics of cometary ices. We present OPRs of ammonia (NH 3 ) in 15 comets based on optical high-dispersion spectroscopic observations of NH 2 , which is a photodissociation product of ammonia in the gaseous coma. The observations were mainly carried out with the VLT/UVES. The OPR of ammonia is estimated from the OPR of NH 2 based on the observations of the NH 2 (0, 9, 0) vibronic band. The absorption lines by the telluric atmosphere are corrected and the cometary C 2 emission lines blended with NH 2 lines are removed in our analysis. The ammonia OPRs show a cluster between 1.1 and 1.2 (this corresponds to a nuclear spin temperature of ∼30 K) for all comets in our sample except for 73P/Schwassmann-Wachmann 3 (73P/SW3). Comet 73P/SW3 (both B- and C-fragments) shows the OPR of ammonia consistent with nuclear spin statistical weight ratio (1.0) that indicates a high-temperature limit as nuclear spin temperature. We compared the ammonia OPRs with other properties ( 14 N/ 15 N ratios in CN, D/H ratios of water, and mixing ratios of volatiles). Comet 73P/SW3 is clearly different from the other comets in the plot of ammonia OPRs versus 14 N/ 15 N ratios in CN. The ammonia OPRs of 1.0 and lower 15 N-fractionation of CN in comet 73P/SW3 imply that icy materials in this comet formed under warmer conditions than other comets. Comets may be classified into two groups in the plot of ammonia OPRs against 14 N/ 15 N ratios in CN.

Prevalence of eating disorders in female and male adolescents (14-15 years).

Science.gov (United States)

Kjelsås, Einar; Bjørnstrøm, Christian; Götestam, K Gunnar

2004-01-01

The main aim of the present study is to establish the prevalence of eating disorders (ED) in adolescents of both genders. To our knowledge, such data have not previously been published using both DSM-IV and DSM-III-R criteria. The study sample consisted of 1960 adolescents (1026 girls and 934 boys), 14-15 years of age. The participants completed the Survey for Eating Disorders (SEDs), including DSM-III-R and DSM-IV diagnoses for all subcategories of ED. Lifetime prevalence of any ED among girls was 17.9% anorexia nervosa (AN) 0.7%, bulimia nervosa (BN) 1.2%, binge eating disorder (BED) 1.5%, and EDs not otherwise specified (EDNOS) 14.6%. Corresponding numbers for boys for any ED is 6.5%, AN 0.2%, BN 0.4%, BED 0.9%, and EDNOS 5.0%. Our prevalence rates on AN, BN, and BED largely support previous school/community-based studies, while our figures on EDNOS were rather high. Generally, we found high numbers for boys with ED.

Capture cross-section and rate of the 14 C (n, γ) 15 C reaction from ...

Indian Academy of Sciences (India)

We calculate the Coulomb dissociation of 15C on a Pb target at 68 MeV/u incident beam energy within the fully quantum mechanical distorted wave Born approximation formalism of breakup reactions. The capture cross-section and the subsequent rate of the 14C(, )15C reaction are calculated from the ...

The first joint congress of the South African Biochemical Society, South African Genetics Society and the South African Society for Microbiology at the University of the Witwatersrand, 29 June-4 July 1986

International Nuclear Information System (INIS)

1986-01-01

The South African Biochemical Society, South African Genetics Society and the South African Society for Microbiology held a joint congress at the University of the Witwatersrand from 29 June - 4 July 1986. The papers delivered cover subjects such as Molecular biology, Genetics, Biochemistry, Medical biochemistry, Physiology, Zoology and Isotope and radiation sciences. Different isotopes are used in labelling studies of enzymes, nutrition, metabolism, viruses, bacteria and other biological assays done in the fields of Biochenmistry, Genetics and Microbiology. This work contains only the abstracts of these papers

Drilling and testing specifications for RRL-6, RRL-14, RRL-15 and DC-3

International Nuclear Information System (INIS)

Moak, D.J.

1982-07-01

RRL-6, RRL-14, RRL-15, and DC-3 will provide data for characterization of the stratigraphy and intraflow structures in the Reference Repository Location. This test specification includes details for the drilling and testing of the boreholes. It includes the predicted stratigraphy, the drilling requirements, description of tests to be conducted, intervals selected for hydrologic testing and a schedule of the drilling and testing activities. 14 refs., 8 figs., 12 tabs

Applications of GIS for highway safety : peer exchange summary report, Cambridge, MA, September 14-15, 2011

Science.gov (United States)

2011-09-30

On September 14-15, 2011, the FHWA's Office of Planning and its Office of Safety sponsored a 1.5-day peer exchange to promote the use of GIS and mapping for highway safety applications. This report offers overviews of the presentations given at the p...

Leaf d15N as a physiological indicator of the responsiveness of N2-fixing alfalfa plants to elevated [CO2], temperature and low water availability

Directory of Open Access Journals (Sweden)

Idoia eAriz

2015-08-01

Full Text Available The natural 15N/14N isotope composition (δ15N of a tissue is a consequence of its N source and N physiological mechanisms in response to the environment. It could potentially be used as a tracer of N metabolism in plants under changing environmental conditions, where primary N metabolism may be complex, and losses and gains of N fluctuate over time. In order to test the utility of δ15N as an indicator of plant N status in N2-fixing plants grown under various environmental conditions, alfalfa (Medicago sativa L. plants were subjected to distinct conditions of [CO2] (400 versus 700 mol mol-1, temperature (ambient versus ambient + 4ºC and water availability (fully watered versus water deficiency - WD. As expected, increased [CO2] and temperature stimulated photosynthetic rates and plant growth, whereas these parameters were negatively affected by WD. The determination of δ15N in leaves, stems, roots and nodules showed that leaves were the most representative organs of the plant response to increased [CO2] and WD. Depletion of heavier N isotopes in plants grown under higher [CO2] and WD conditions reflected decreased transpiration rates, but could also be related to a higher N demand in leaves, as suggested by the decreased leaf N and total soluble protein (TSP contents detected at 700 mol mol-1 [CO2] and WD conditions. In summary, leaf δ15N provides relevant information integrating parameters which condition plant responsiveness (e.g. photosynthesis, TSP, N demand and water transpiration to environmental conditions.

Structure of a 14-3-3σ–YAP phosphopeptide complex at 1.15 Å resolution

International Nuclear Information System (INIS)

Schumacher, Benjamin; Skwarczynska, Malgorzata; Rose, Rolf; Ottmann, Christian

2010-01-01

The first structure of a 14-3-3 protein–phosphopeptide complex is reported at 1.15 Å resolution. The YAP 14-3-3-binding motif is revealed for the first time using crystallographic tools. The 14-3-3 proteins are a class of eukaryotic acidic adapter proteins, with seven isoforms in humans. 14-3-3 proteins mediate their biological function by binding to target proteins and influencing their activity. They are involved in pivotal pathways in the cell such as signal transduction, gene expression, enzyme activation, cell division and apoptosis. The Yes-associated protein (YAP) is a WW-domain protein that exists in two transcript variants of 48 and 54 kDa in humans. By transducing signals from the cytoplasm to the nucleus, YAP is important for transcriptional regulation. In both variants, interaction with 14-3-3 proteins after phosphorylation of Ser127 is important for nucleocytoplasmic trafficking, via which the localization of YAP is controlled. In this study, 14-3-3σ has been cloned, purified and crystallized in complex with a phosphopeptide from the YAP 14-3-3-binding domain, which led to a crystal that diffracted to 1.15 Å resolution. The crystals belonged to space group C222 1 , with unit-cell parameters a = 82.3, b = 112.1, c = 62.9 Å

The microdose rapid 14C urea breath test compares well with the original rapid 14 breath test

International Nuclear Information System (INIS)

Bellon, M.S.; Bartholomeusz, F.D.L.; Chatterton, B.E.

2000-01-01

Full text: The 14 C urea breath test (CUBT) is a sensitive test used in the detection of H. pylori infection. The rapid 14 CUBT using 185 KBq of 14 C urea showed a sensitivity of 100% when tested in 36 patients. The aim of this study was to compare the results of the 14 CUBT performed following the ingestion of 37KBq microdose 14 C urea capsule (Bicapsule, Trimed) with the earlier method which uses 185 KBq 14 C urea. 19 patients (nine female age 21-52 yrs) were studied. All subjects first underwent a 14 CUBT with the microdose capsule and a single 15 minute post ingestion sample. An hour later the test was repeated but with a dose of 185 KBq 14 C urea in liquid form. A normal result was taken as 2 = 0.92). This is shown above. The Rapid 14 CUBT performed following the microdose capsule whilst reducing patient radiation exposure is an accurate test for the detection of H. pylori. Copyright (2000) The Australian and New Zealand Society of Nuclear Medicine Inc

Stellar reaction of 14N(p,γ)15O and hydrogen burning in massive stars

International Nuclear Information System (INIS)

Schroeder, U.; Becker, H.W.; Bogaert, G.; Goerres, J.; Rolfs, C.; Trautvetter, H.P.; Azuma, R.E.; Campbell, C.; King, J.D.; Vise, J.

1987-01-01

The capture reaction 14 N(p,γ) 15 O has been investigated in the energy range E p =0.2 to 3.6 MeV with the use of windowless gas targets as well as implanted 14 N solid targets of high isotopic purity. The measurement of absolute cross sections, γ-ray angular distributions and excitation functions is reported. The data provide information on the capture amplitudes involved in the transitions to all bound states of 15 O. The astrophysical S-factor at stellar energies has been determined by means of theoretical fits. The result of S(0)=3.20 keV . b is in good agreement with the value incorporated in the compilations. Also discussed are the nuclear physics aspects of the data. (orig.)

11 CFR 100.14 - State committee, subordinate committee, district, or local committee (2 U.S.C. 431(15)).

Science.gov (United States)

2010-01-01

... 11 Federal Elections 1 2010-01-01 2010-01-01 false State committee, subordinate committee, district, or local committee (2 U.S.C. 431(15)). 100.14 Section 100.14 Federal Elections FEDERAL ELECTION COMMISSION GENERAL SCOPE AND DEFINITIONS (2 U.S.C. 431) General Definitions § 100.14 State committee...

Civil Society Participation at CONFINTEA VI

Science.gov (United States)

Haddad, Sergio

2012-01-01

This article analyzes the participation of civil society in the Sixth International Conference on Adult Education held in Belem do Para, Brazil, 1-4 December 2009. As a foundation, the discussion first illuminates the important role that civil society in general plays in democratic issues and the relation between the state and society followed by…

American Fisheries Society 136th Annual Meeting Lake Placid, NY 10-14 September, 2006

Science.gov (United States)

Einhouse, D.; Walsh, M.G.; Keeler, S.; Long, J.M.

2005-01-01

The New York Chapter of the American Fisheries Society and the New York State Department of Environmental Conservation invite you to experience the beauty of New York's famous Adirondack Park as the American Fisheries Society (AFS) convenes its 136th Annual Meeting in the legendary Olympic Village of Lake Placid, NY, 10-14 September 2006. Our meeting theme "Fish in the Balance" will explore the interrelation between fish, aquatic habitats, and man, highlighting the challenges facing aquatic resource professionals and the methods that have been employed to resolve conflicts between those that use or have an interest in our aquatic resources. As fragile as it is beautiful, the Adirondack Region is the perfect location to explore this theme. Bordered by Mirror Lake and its namesake, Lake Placid, the Village of Lake Placid has small town charm, but all of the conveniences that a big city would provide. Whether its reliving the magic of the 1980 hockey team's "Miracle on Ice" at the Lake Placid Olympic Center, getting a panoramic view of the Adirondack high peaks from the top of the 90 meter ski jumps, fishing or kayaking in adjacent Mirror Lake, hiking a mountain trail, or enjoying a quiet dinner or shopping excursion in the various shops and restaurants that line Main Street, Lake Placid has something for everyone.

Occupational physiology

CERN Document Server

Toomingas, Allan; Tornqvist, Ewa Wigaeus

2011-01-01

In a clear and accessible presentation, Occupational Physiology focuses on important issues in the modern working world. Exploring major public health problems-such as musculoskeletal disorders and stress-this book explains connections between work, well-being, and health based on up-to-date research in the field. It provides useful methods for risk assessment and guidelines on arranging a good working life from the perspective of the working individual, the company, and society as a whole.The book focuses on common, stressful situations in different professions. Reviewing bodily demands and r

Physical and Physiological Demands of Recreational Team Handball for Adult Untrained Men

DEFF Research Database (Denmark)

Póvoas, Susana C A; Castagna, Carlo; Resende, Carlos

2017-01-01

Lack of motivation to exercise was reported as a major cause of sedentary behavior in adulthood. This descriptive study examines the acute physical and physiological demands of recreational team handball and evaluates whether it could be suggested as an exercise mode for fitness and health......%  HRmax for 24% (14 ± 15 min) of total match time. Match average and peak blood lactate values were 3.6 ± 1.3 and 4.2 ± 1.2 mM, respectively. Recreational team handball is an intermittent high-intensity exercise mode with physical and physiological demands in the range of those found to have a positive...... effect on aerobic, anaerobic, and musculoskeletal fitness in adult individuals. Training studies considering recreational team handball as a health enhancing intervention are warranted....

Blended learning within an undergraduate exercise physiology laboratory.

Science.gov (United States)

Elmer, Steven J; Carter, Kathryn R; Armga, Austin J; Carter, Jason R

2016-03-01

In physiological education, blended course formats (integration of face-to-face and online instruction) can facilitate increased student learning, performance, and satisfaction in classroom settings. There is limited evidence on the effectiveness of using blending course formats in laboratory settings. We evaluated the impact of blended learning on student performance and perceptions in an undergraduate exercise physiology laboratory. Using a randomized, crossover design, four laboratory topics were delivered in either a blended or traditional format. For blended laboratories, content was offloaded to self-paced video demonstrations (∼15 min). Laboratory section 1 (n = 16) completed blended laboratories for 1) neuromuscular power and 2) blood lactate, whereas section 2 (n = 17) completed blended laboratories for 1) maximal O2 consumption and 2) muscle electromyography. Both sections completed the same assignments (scored in a blinded manner using a standardized rubric) and practicum exams (evaluated by two independent investigators). Pre- and postcourse surveys were used to assess student perceptions. Most students (∼79%) watched videos for both blended laboratories. Assignment scores did not differ between blended and traditional laboratories (P = 0.62) or between sections (P = 0.91). Practicum scores did not differ between sections (both P > 0.05). At the end of the course, students' perceived value of the blended format increased (P learning key foundational content through video demonstrations before class greatly enhanced their learning of course material compared with a preassigned reading (94% vs. 78%, P Blended exercise physiology laboratories provided an alternative method for delivering content that was favorably perceived by students and did not compromise student performance. Copyright © 2016 The American Physiological Society.

Thermodynamic and transport properties of (1-Butanol + 1,4-Butanediol) at temperatures from (298.15 to 318.15) K

International Nuclear Information System (INIS)

Zorebski, Edward; Geppert-Rybczynska, Monika

2010-01-01

Densities and kinematic viscosities have been measured for (1-butanol + 1,4-butanediol) over the temperature range from (298.15 to 318.15) K. The speeds of sound within the temperature range from (293.15 to 318.15) K have been measured as well. Using these results and literature values of isobaric heat capacities, the molar volumes, isentropic and isothermal compressibility coefficients, molar isentropic and isothermal compressibilities, isochoric heat capacities as well as internal pressures were calculated. Also the corresponding excess and deviation values (excess molar volumes, excess isentropic and isothermal compressibility coefficients, excess molar isentropic and isothermal compressibilities, different defined deviation speed of sound and dynamic viscosity deviations) were calculated. The excess values are negative over the whole concentration and temperature range. The excess and deviation values are expressed by Redlich-Kister polynomials and discussed in terms of the variations of the structure of the system caused by the participation of the two different alcohol molecules in the dynamic intermolecular association process through hydrogen bonding at various temperatures. The predictive abilities of Grunberg-Nissan and McAllister equations for viscosities of mixtures have also been examined.

Physiological integration enhanced the tolerance of Cynodon dactylon to flooding.

Science.gov (United States)

Li, Z J; Fan, D Y; Chen, F Q; Yuan, Q Y; Chow, W S; Xie, Z Q

2015-03-01

Many flooding-tolerant species are clonal plants; however, the effects of physiological integration on plant responses to flooding have received limited attention. We hypothesise that flooding can trigger changes in metabolism of carbohydrates and ROS (reactive oxygen species) in clonal plants, and that physiological integration can ameliorate the adverse effects of stress, subsequently restoring the growth of flooded ramets. In the present study, we conducted a factorial experiment combining flooding to apical ramets and stolon severing (preventing physiological integration) between apical and basal ramets of Cynodon dactylon, which is a stoloniferous perennial grass with considerable flooding tolerance. Flooding-induced responses including decreased root biomass, accumulation of soluble sugar and starch, as well as increased activity of superoxide dismutase (SOD) and ascorbate peroxidase (APX) in apical ramets. Physiological integration relieved growth inhibition, carbohydrate accumulation and induction of antioxidant enzyme activity in stressed ramets, as expected, without any observable cost in unstressed ramets. We speculate that relief of flooding stress in clonal plants may rely on oxidising power and electron acceptors transferred between ramets through physiological integration. © 2014 German Botanical Society and The Royal Botanical Society of the Netherlands.

Using measures of single-cell physiology and physiological state to understand organismic aging.

Science.gov (United States)

Mendenhall, Alexander; Driscoll, Monica; Brent, Roger

2016-02-01

Genetically identical organisms in homogeneous environments have different lifespans and healthspans. These differences are often attributed to stochastic events, such as mutations and 'epimutations', changes in DNA methylation and chromatin that change gene function and expression. But work in the last 10 years has revealed differences in lifespan- and health-related phenotypes that are not caused by lasting changes in DNA or identified by modifications to DNA or chromatin. This work has demonstrated persistent differences in single-cell and whole-organism physiological states operationally defined by values of reporter gene signals in living cells. While some single-cell states, for example, responses to oxygen deprivation, were defined previously, others, such as a generally heightened ability to make proteins, were, revealed by direct experiment only recently, and are not well understood. Here, we review technical progress that promises to greatly increase the number of these measurable single-cell physiological variables and measureable states. We discuss concepts that facilitate use of single-cell measurements to provide insight into physiological states and state transitions. We assert that researchers will use this information to relate cell level physiological readouts to whole-organism outcomes, to stratify aging populations into groups based on different physiologies, to define biomarkers predictive of outcomes, and to shed light on the molecular processes that bring about different individual physiologies. For these reasons, quantitative study of single-cell physiological variables and state transitions should provide a valuable complement to genetic and molecular explanations of how organisms age. © 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Nitrogen dynamics in stream wood samples incubated with [14C]lignocellulose and potassium[15N]nitrate

International Nuclear Information System (INIS)

Aumen, N.G.; Bottomley, P.J.; Gregory, S.V.

1985-01-01

Surface wood samples obtained from a Douglas fir log incubated in vitro with [ 14 C]lignocellulose in a defined mineral salts medium supplemented with 10 mg of N liter -1 of 15 N-labeled NO 3 - (50 atom % 15 N). Evolution of 14 CO 2 , distribution and isotopic dilution of 15 N, filtrate N concentrations, and the rates of denitrification, N 2 fixation, and respiration were measured at 6, 12, and 18 days of incubation. The organic N content of the lignocellulose-wood sample mixture had increased from 132 μg of N to a maximum of 231 μg of N per treatment after 6 days of incubation. Rates of [ 14 C]lignocellulose decomposition were greatest during the first 6 days and then began to decline over the remaining 12 days. Total CO 2 evolution was also highest at day 6 and declined steadily over the remaining duration of the incubation. Filtrate NH 4 + -N increased from background levels to a final value of 57 μg of N per treatment. Filtrate NO 3 - N completely disappeared by day 6, and organic N showed a slight decline between days 12 and 18. The majority of the 15 N that could be recovered appeared in the particulate organic fraction by day 6 (41 μg of N), and the filtrate NH 4 + N fraction contained 11 μg of 15 N by day 18. The 15 N enrichment values of the filtrate NH 4 + and the inorganic N associated with the particulate fraction had increased to approximately 20 atom % 15 N by 18 days of incubation, whereas the particulate organic fraction reached its highest enrichment by day 6. Measurements of N 2 fixation and denitrification indicated an insignificant gain or loss of N from the experimental system by these processes. The data show that woody debris in stream ecosystems might function as a rapid and efficient sink for exogenous N, resulting in stimulation of wood decomposition and subsequent activation of other N cycling processes

15 CFR 14.22 - Payment.

Science.gov (United States)

2010-01-01

... AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, OTHER NON-PROFIT, AND COMMERCIAL ORGANIZATIONS Post-Award Requirements Financial and Program Management § 14.22 Payment. (a) Payment methods... transfer of funds and disbursement by the recipient, and financial management systems that meet the...

Electroexcitation of 15N levels from 9.7 to 14.7 MeV

International Nuclear Information System (INIS)

Ansaldo, E.J.; Bergstrom, J.C.; Caplan, H.S.; Yen, R.

1977-01-01

The electromagnetic form factors of five transitions in 15 N have been measured for momentum transfers between 0.48 and 1.27 fm -1 . The transitions observed were identified with levels at 9.76, 10.80, 11.88, 12.50, and 14.7 MeV excitation energy. Ground state radiative widths have been extracted by a Helm model analysis. (author)

Pore-expanded SBA-15 sulfonic acid silicas for biodiesel synthesis.

Science.gov (United States)

Dacquin, J P; Lee, A F; Pirez, C; Wilson, K

2012-01-07

Here we present the first application of pore-expanded SBA-15 in heterogeneous catalysis. Pore expansion over the range 6-14 nm confers a striking activity enhancement towards fatty acid methyl ester (FAME) synthesis from triglycerides (TAG), and free fatty acid (FFA), attributed to improved mass transport and acid site accessibility. This journal is © The Royal Society of Chemistry 2012

Home geriatric physiological measurements.

Science.gov (United States)

Tamura, Toshiyo

2012-10-01

In an ageing society, the elderly can be monitored with numerous physiological, physical and passive devices. Sensors can be installed in the home for continuous mobility assistance and unobtrusive disease prevention. This review presents several modern sensors, which improve the quality of life and assist the elderly, disabled people and their caregivers. The main concept of geriatric sensors is that they are capable of providing assistance without limiting or disturbing the subject's daily routine, giving him or her greater comfort, pleasure and well-being. Furthermore, this review includes associated technologies of wearable/implantable monitoring systems and the 'smart-house' project. This review concludes by discussing future challenges of the future aged society.

Home geriatric physiological measurements

International Nuclear Information System (INIS)

Tamura, Toshiyo

2012-01-01

In an ageing society, the elderly can be monitored with numerous physiological, physical and passive devices. Sensors can be installed in the home for continuous mobility assistance and unobtrusive disease prevention. This review presents several modern sensors, which improve the quality of life and assist the elderly, disabled people and their caregivers. The main concept of geriatric sensors is that they are capable of providing assistance without limiting or disturbing the subject's daily routine, giving him or her greater comfort, pleasure and well-being. Furthermore, this review includes associated technologies of wearable/implantable monitoring systems and the ‘smart-house’ project. This review concludes by discussing future challenges of the future aged society. (topical review)

Determination of the asymptotic normalization coefficients for ¹⁴C + n <--> ¹⁵C, the ¹⁴C(n, gamma)¹⁵C reaction rate, and evaluation of a new method to determine spectroscopic factors

Energy Technology Data Exchange (ETDEWEB)

McCleskey, M; Mukhamedzhanov, A M; Trache, L; Tribble, R E; Banu, A; Eremenko, V; Goldberg, V Z; Lui, Y W; McCleskey, E; Roeder, B T; Spiridon, A; Carstoiu, F; Burjan, V; Hons, Z; Thompson, I J

2014-04-17

The ¹⁴C + n <--> ¹⁵C system has been used as a test case in the evaluation of a new method to determine spectroscopic factors that uses the asymptotic normalization coefficient (ANC). The method proved to be unsuccessful for this case. As part of this experimental program, the ANCs for the ¹⁵C ground state and first excited state were determined using a heavy-ion neutron transfer reaction as well as the inverse kinematics (d,p) reaction, measured at the Texas A&M Cyclotron Institute. The ANCs were used to evaluate the astrophysical direct neutron capture rate on ¹⁴C, which was then compared with the most recent direct measurement and found to be in good agreement. A study of the ¹⁵C SF via its mirror nucleus ¹⁵F and a new insight into deuteron stripping theory are also presented.

Transformation of /sup 14/C labelled plant components in soil in relation to immobilization and remineralization of /sup 15/N fertilizer

Energy Technology Data Exchange (ETDEWEB)

Azam, F.; Haider, K.; Malik, K.A.

1985-01-01

Uniformly /sup 14/C labeled glucose, cellulose and wheat straw and specifically /sup 14/C labeled lignin component in corn stalks were aerobically incubated for 12 weeks in a chernozem soil along with /sup 15/N labeled ammonium sulfate. Glucose was most readily decomposed, followed in order by cellulose, wheat straw and corn stalk lignins labeled at methoxyl-, side chain 2- and ring-C. More than 50% of /sup 14/C applied as glucose, cellulose and wheat straw evolved as CO/sub 2/ during the first week. Lignin however, decomposed relatively slowly. A higher proportion of /sup 14/C was transformed into microbial biomass whereas lignins contributed a little to this fraction. After 12 weeks of incubation nearly 60% of the lignin /sup 14/C was found in humic compounds of which more than 70% was resistant to hydrolysis with 6N HCl. Maximum incorporation of /sup 15/N in humic compounds was observed in cellulose amended soil. However, in this case more than 80% of the /sup 15/N was in hydrolysable forms. Immobilization-remineralization of applied /sup 15/N was most rapid in glucose treated soil and a complete immobilization followed by remineralization was observed after 3 days. The process was much slow in soil treated with cellulose, wheat straw or corn stalks. More than 70% of the newly immobilized N was in hydrolysable forms mainly representing the microbial component. Serial hydrolysis of soil at different incubation intervals showed a greater proportion of 6N HCl hydrolysable /sup 14/C and /sup 15/N in fractions representing microbial material. /sup 14/C from lignin carbons was relatively more uniformly distributed in different fractions as compared to glucose, cellulose and wheat straw where a major portion of /sup 14/C was in easily hydrolysable fractions. 25 refs., 3 figs., 4 tabs.

Basic results and prospects for development of physiology of work of miners of Donbass coal mines

Energy Technology Data Exchange (ETDEWEB)

Grebnyak, V.P. (Institut Gigieny Truda i Profzabolevanii, Donetsk (USSR))

1988-11-01

In the Donbass, tunnelers and stopers work under unfavorable factors of the underground environment: heavy physical work in limited space, increased possibility of accidents and personal risk, a warming microclimate, noise and dust. In view of this, role of physiology of work consists in guaranteeing normalization of work load, in development of rational regiments of work and rest, and a basis of psychophysical criteria of professional choice, development of physiologically based methods of rehabilitation, preparation of miners for factors of underground medium. Physiologic normalization of work of miners can be achieved by establishing norms of work and rest. With mechanization of mining, level of tension of work has increased, requiring longer rest periods after work. Increased temperatures of deep mines necessitate corresponding increase in rest periods, reducing exhaustion of workers and physiologically increasing productivity of work 12-15%. Investigations in physiology of work of miners have established norms of loads, national regimens of work and rest, ways to prevent disease and reduce physiologic tension of organism to prevent functional breakdowns and illnesses. For the future, further study of mechanisms causing strain and exhaustion affecting work capacity of miners is recommended. 14 refs.

Incorporation of 14CO2 and 15NH4 into amino acids of the two subunits of fraction 1 protein in spinach leaves

International Nuclear Information System (INIS)

Sano, Chiaki; Ito, Osamu; Yoneyama, Tadakatsu; Kumazawa, Kikuo

1978-01-01

14 Co 2 and 15 NH 4 were applied to spinach leaf discs, and the incorporation of 14 C and 15 N into the constituent amino acids of subunits in Fraction 1 protein was traced. The solution containing NaH 14 CO 3 and ( 15 NH 4 ) 2 SO 4 was vacuum-infiltrated into leaf discs, which were then incubated under light condition for 8 hr. The leaf discs were immediately frozen with liquid nitrogen after the incubation. The Fraction 1 protein was isolated and purified according to Kawashima's method, and separated into two subunits by his method. These subunits were hydrolyzed, and the hydrolyzates were analyzed by amino acid analyzer. The determination of 14 C activity and 15 N content in each amino acid was performed as previously described. Glycine and aspartic acid showed the highest 14 C specific activity among free amino acids. The distribution pattern of 14 C in bound amino acids almost reflected the distribution in free amino acids, though the 14 C specific activity in the former was lower than that in the latter. There was some difference in the 14 C specific activity of large and small subunits. The 15 N content of glutamine was the highest among free amino acids. This result coincides with the previous conclusion that when ammonium was applied to the free cells separated from spinach leaves, it was initially incorporated into glutamine in the sequence of its assimilation. Glutamic acid and serine showed the highest 15 N content among bound amino acids. (Kobatake, H.)

Effects of carbon dioxide exposure on intensively cultured rainbow trout Oncorhynchus mykiss: Physiological responses and fillet attributes

Science.gov (United States)

Danley, M.L.; Kenney, P.B.; Mazik, P.M.; Kiser, R.; Hankins, J.A.

2005-01-01

Rainbow trout Oncorhynchus mykiss (261.6 ?? 24.7 g initial weight, mean ?? SEM) at 13.1 ?? 0.2 C were exposed for 94 d to one of three CO2 treatments: control (22.1 ?? 2.8 mg/L), medium (34.5 ?? 3.8 mg/L), or high (48.7 ?? 4.4 mg/L). Trout were checked daily for survival, and fish were sampled at 0, 28, 56, and 84 d for physiological responses, growth, and fillet quality assessments. Trout were also challenged to a 15-min crowding stress at 93 d to assess their ability to initiate a stress response during hypercapnia. Chronically exposed trout showed nearly 100% survival through 84 d exposure (1 of 1,500 fish died). Growth and physiological results showed that increasing elevated CO2 concentrations result in corresponding decreased growth rates and CO2-specific physiological parameters: The medium and high CO2 treatments had significantly slower growth and subsequently smaller fish by 84 d. Exposed trout also showed significantly (P smoked fillet weights. Chronic CO2 exposure did not result in notable changes in ultimate muscle pH. Exposure to 15-min crowding stress at 93 d resulted in significant changes in hematocrit, plasma cortisol, glucose, and chloride for all treatment groups. CO2-specific changes were detected in hematocrit, plasma cortisol, and plasma chloride responses following the 15-min crowding stress. ?? Copyright by the World Aquaculture Society 2005.

Features of high-speed and strength qualities development in young biathlonists aged 14–15 in the preparatory period

Directory of Open Access Journals (Sweden)

Artem Burla

2015-04-01

Full Text Available Purpose: to substantiate a methodology of high-speed and strength qualities development of young biathlonists aged 14–15 during the preparatory period. Material and Methods: young biathlonists aged 14–15 from control and experimental groups took part in the research. There were 12 athletes in each group. Pedagogical methods and methods of mathematical statistics were used in the work. Pedagogical methods of researches were used for level definition of high-speed and strength qualities development of young biathlonists. Results: reliable increase of motive qualities and polydynamometry results testing of young biathlonists from the experimental group due to implementation of the experimental methodology in the preparatory period is established. Conclusions: application of the developed complexes in the preparatory period in the experimental group of young biathlonists aged 14–15 allows to raise indices of motive qualities and polydynamometry testing statistically significantly.

15 theses on power

Directory of Open Access Journals (Sweden)

Susen Simon

2014-01-01

Full Text Available This article seeks to contribute to a critical understanding of the multifaceted nature of power, emphasizing its capacity to shape the development of society by permeating constitutive aspects of human reality. To this end, the article proposes an outline of a multidimensional approach to power. It does so by identifying and examining several - arguably universal - features and functions of power. On the basis of 15 theses, it is argued that, within the social world, the power of power derives from the fact that it is (1 ubiquitous, (2 productive, (3 relational, (4 intangible, (5 habitual, (6 discursive, (7 corporeal, (8 polycentric, (9 performative, (10 normative, (11 spatial, (12 temporal, (13 disciplinary, (14 circular, and (15 transcendental. By way of conclusion, the article provides a comprehensive summary of the main insights gained and challenges arising from such a multidimensional approach to power.

Use of urinary 13,14, dihydro-15-keto-prostaglandin F2α (PGFM) concentrations to diagnose pregnancy and predict parturition in the giant panda (Ailuropoda melanolecua).

Science.gov (United States)

Roberts, Beth M; Brown, Janine L; Kersey, David C; Snyder, Rebecca J; Durrant, Barbara S; Kouba, Andrew J

2018-01-01

Pregnancy determination is difficult in the giant panda (Ailuropoda melanolecua), representing a challenge for ex situ conservation efforts. Research in other species experiencing pseudopregnancy indicates that urinary/fecal concentrations of 13,14, dihydro-15-keto-prostaglandin F2α (PGFM) can accurately determine pregnancy status. Our objective was to determine if urinary PGFM concentrations are associated with pregnancy status in the giant panda. Urinary PGFM concentrations were measured in female giant pandas (n = 4) throughout gestation (n = 6) and pseudopregnancy (n = 4) using a commercial enzyme immunoassay. Regardless of pregnancy status, PGFM excretion followed a predictable pattern: 1) baseline concentrations for 11-19 weeks following ovulation; 2) a modest, initial peak 14-36 days after the start of the secondary urinary progestagen rise; 3) a subsequent period of relatively low concentrations; and 4) a large, terminal peak at the end of the luteal phase. Pregnant profiles were distinguished by an earlier initial peak (P = 0.024), higher inter-peak concentrations (P panda. Furthermore, this is the only species known to exhibit a significant PGFM increase during pseudopregnancy, suggesting a unique physiological mechanism for regulating the end of the luteal phase in the giant panda.

First Measurement of the 14N/15N Ratio in the Analog of the Sun Progenitor OMC-2 FIR4

Science.gov (United States)

Kahane, Claudine; Jaber Al-Edhari, Ali; Ceccarelli, Cecilia; López-Sepulcre, Ana; Fontani, Francesco; Kama, Mihkel

2018-01-01

We present a complete census of the 14N/15N isotopic ratio in the most abundant N-bearing molecules toward the cold envelope of the protocluster OMC-2 FIR4, the best known Sun progenitor. To this scope, we analyzed the unbiased spectral survey obtained with the IRAM 30 m telescope at 3, 2, and 1 mm. We detected several lines of CN, HCN, HNC, HC3N, N2H+, and their respective 13C and 15N isotopologues. The lines’ relative fluxes are compatible with LTE conditions, and moderate line opacities have been corrected via a population diagram method or theoretical relative intensity ratios of the hyperfine structures. The five species lead to very similar 14N/15N isotopic ratios, without any systematic difference between amine- and nitrile-bearing species as previously found in other protostellar sources. The weighted average of the 14N/15N isotopic ratio is 270 ± 30. This 14N/15N value is remarkably consistent with the [250–350] range measured for the local galactic ratio but significantly differs from the ratio measured in comets (around 140). High-angular resolution observations are needed to examine whether this discrepancy is maintained at smaller scales. In addition, using the CN, HCN, and HC3N lines, we derived a 12C/13C isotopic ratio of 50 ± 5.

Perinatal characteristics among early (10–14 years old and late (15–19 years old pregnant adolescents

Directory of Open Access Journals (Sweden)

Alves João

2012-09-01

Full Text Available Abstract Background Pregnancy in adolescents is a worldwide health problem and has been mostly common in poor populations. It is not clear if socioeconomic or biological factors are the main determinants of perinatal adverse outcomes in pregnant adolescents. Adolescents under 15 years old may present a high growth rate which may contribute to impair fetal growth. Our aim is to compare perinatal characteristics among early (aged 10 to 14 years and late (aged 15 to 19 years pregnant adolescents. Methods A cross-sectional study was performed using data from Pernambuco State 2009, obtained from DATASUS/SISNAC, a Brazilian Government, open-access public health database. Maternal and neonatal outcomes were compared between early (aged 10–14 years and late (aged 15–19 years pregnant adolescents. Family income was compared between early and late pregnant adolescents using a sample of 412 subjects evaluated at Instituto de Medicina Integral Prof. Fernando Figueira (IMIP during 2011. Statistical comparisons were made using the chi-square test was used with a significant level of 0.05; bivariate and multivariate analysis were performed. This project was approved by the Institutional Ethics Review Board. Results Data from 31,209 pregnant adolescents were analyzed. 29,733 (95.2% were aged 15 to 19 years and 1,476 (4.7% were aged 10 to 14 years. There were significant differences with respect to marital status, education level and number of prenatal visits of mothers aged 10 to 14 years compared to 15 to 19 years. Of importance, early adolescents had a greater rate of neonates born premature and with low birth weight. Prematurity and low birth weight remained statistically significant after multivariate analysis. Conclusions Early aged adolescents may have an increased risk of prematurity and low birth weight. These findings highlight the potential role of biological factors in newborn outcomes in pregnant adolescents.

Complex chromosome rearrangements related 15q14 microdeletion plays a relevant role in phenotype expression and delineates a novel recurrent syndrome

Directory of Open Access Journals (Sweden)

Tomaiuolo Anna

2011-04-01

Full Text Available Abstract Complex chromosome rearrangements are constitutional structural rearrangements involving three or more chromosomes or having more than two breakpoints. These are rarely seen in the general population but their frequency should be much higher due to balanced states with no phenotypic presentation. These abnormalities preferentially occur de novo during spermatogenesis and are transmitted in families through oogenesis. Here, we report a de novo complex chromosome rearrangement that interests eight chromosomes in eighteen-year-old boy with an abnormal phenotype consisting in moderate developmental delay, cleft palate, and facial dysmorphisms. Standard G-banding revealed four apparently balanced traslocations involving the chromosomes 1;13, 3;19, 9;15 and 14;18 that appeared to be reciprocal. Array-based comparative genomic hybridization analysis showed no imbalances at all the breakpoints observed except for an interstitial microdeletion on chromosome 15. This deletion is 1.6 Mb in size and is located at chromosome band 15q14, distal to the Prader-Willi/Angelman region. Comparing the features of our patient with published reports of patients with 15q14 deletion this finding corresponds to the smallest genomic region of overlap. The deleted segment at 15q14 was investigated for gene content.

Fluoxetine: clinical pharmacology and physiologic disposition

International Nuclear Information System (INIS)

Lemberger, L.; Bergstrom, R.F.; Wolen, R.L.; Farid, N.A.; Enas, G.G.; Aronoff, G.R.

1985-01-01

Fluoxetine (30 mg), administered for 7 days to normal volunteers, produced a 66% inhibition of tritiated serotonin uptake into platelets. Plasma concentrations of fluoxetine correlated positively with inhibition of serotonin uptake. Fluoxetine is well absorbed after oral administration in both the fed and fasted states and demonstrates dose proportionality. Fluoxetine disappears from plasma with a half-life of 1-3 days; its metabolite norfluoxetine has a plasma half-life of 7-15 days. After administration of 14 C-fluoxetine, approximately 65% of the administered dose of radioactivity is recovered in urine and about 15% in feces. Fluoxetine, given as a single dose or in multiple doses over 8 days, did not produce significant effects on the plasma disappearance of warfarin, diazepam, tolbutamide, or chlorothiazide. Coadministration of fluoxetine and ethanol did not result in an increase from control values in the blood ethanol levels, nor did it produce significant changes in physiologic, psychometric, or psychomotor activity. Pharmacokinetics of fluoxetine in the elderly and normal volunteers appear to be similar. In addition, pharmacokinetic analyses in patients with varying degrees of renal impairment did not show significant differences from healthy subjects

15 CFR 700.14 - Preferential scheduling.

Science.gov (United States)

2010-01-01

...) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE NATIONAL SECURITY INDUSTRIAL BASE REGULATIONS DEFENSE PRIORITIES AND ALLOCATIONS SYSTEM Industrial Priorities § 700.14 Preferential scheduling. (a) A...

Myths and Truths from Exercise Physiology

Science.gov (United States)

Kieffer, H. Scott

2008-01-01

This article addresses some of the common myths in the field of exercise physiology. Some of the myths are misconstrued facts that have developed over time, such as the myth of localized fat reduction. Other myths are unproved or collective beliefs used to justify a social institution; we see this occur in the form of "fitness fads." Society is…

The XIIIth International Physiological Congress in Boston in 1929: American physiology comes of age.

Science.gov (United States)

Rall, Jack A

2016-03-01

In the 19th century, the concept of experimental physiology originated in France with Claude Bernard, evolved in Germany stimulated by the teaching of Carl Ludwig, and later spread to Britain and then to the United States. The goal was to develop a physicochemical understanding of physiological phenomena. The first International Physiological Congress occurred in 1889 in Switzerland with an emphasis on experimental demonstrations. The XIIIth Congress, the first to be held outside of Europe, took place in Boston, MA, in 1929. It was a watershed meeting and indicated that American physiology had come of age. Meticulously organized, it was the largest congress to date, with over 1,200 participants from more than 40 countries. Getting to the congress was a cultural adventure, especially for the 400 scientists and their families from over 20 European countries, who sailed for 10 days on the S.S. Minnekahda. Many of the great physiologists of the world were in attendance, including 22 scientists who were either or would become Nobel Laureates. There were hundreds of platform presentations and many experimental demonstrations. The meeting was not without controversy as a conflict, still not completely settled, arose over the discovery of ATP. After the meeting, hundreds of participants made a memorable trip to the Marine Biological Laboratory at Woods Hole, MA, which culminated in a "good old fashioned Cape Cod Clambake." Although not as spectacular as the 1929 congress, the physiological congresses have continued with goals similar to those established more than a century ago. Copyright © 2016 The American Physiological Society.

9-Hydroxyprostaglandin dehydrogenase in rat kidney cortex converts prostaglandin I2 into 15-keto-13,14-dihydro 6-ketoprostaglandin E1.

Science.gov (United States)

Pace-Asciak, C R; Domazet, Z

1984-11-14

15-Keto-13,14-dihydro 6-ketoprostaglandin E1 was positively identified by gas chromatography-mass spectrometry with negative-ion chemical ionisation detection from samples of rat kidney high-speed supernatant incubated with prostaglandin I2 in the presence of NAD+. A decreased formation of this product was observed when NAD+ was substituted with NADP+ and none was observed in the absence of nucleotide or substrate prostaglandin I2. Experiments with [9 beta-3H]prostaglandin I2 showed a time- and concentration-dependent loss of tritium which appeared as tritiated water, typical of reaction of [9 beta-3H]prostaglandin substrates with the enzyme, 9-hydroxyprostaglandin dehydrogenase. Time-course measurements of the appearance of tritiated water showed similar rates with 6-keto[9 beta-3H]prostaglandin F1 alpha and 15-keto-13,14-dihydro 6-keto[9 beta-3H]prostaglandin F1 alpha as substrates. These experiments suggest that the transformation of prostaglandin I2 and 6-ketoprostaglandin F1 alpha into the 15-keto-13,14-dihydro 6-ketoprostaglandin E1 catabolite occurs in this in vitro preparation via the corresponding 15-keto-13,14-dihydro catabolite of 6-ketoprostaglandin F1 alpha.

Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Mobile Learning (Lisbon, Portugal, March 14-16, 2013)

Science.gov (United States)

Sánchez, Inmaculada Arnedillo, Ed.; Isaías, Pedro, Ed.

2013-01-01

These proceedings contain the papers of the International Conference on Mobile Learning 2013, which was organised by the International Association for Development of the Information Society, in Lisbon, Portugal, March 14-16, 2013. The Mobile Learning 2013 International Conference seeks to provide a forum for the presentation and discussion of…

5α-cholest-8(14)-en-3β-ol-15-one. Studies on its metabolism in cultured cells and male baboons. Volume 1 and 2

International Nuclear Information System (INIS)

Pajewski, T.N.

1989-01-01

5α-Cholest-8(14)-en-3β-ol-15-one is a potent is a potent inhibitor of cholesterol biosynthesis which has been found to have significant hypocholesterolemic action upon oral administration to rodents and nonhuman primates. The metabolism of [2,4- 3 H]5α-cholest-8(14)-3n-3β-ol-15-one was studied in Chinese hamster ovary (CHO-K1) cells. The incorporation of the labeled 15-ketosterol into the cells was linear with respect to sterol concentration in the medium over the range of concentrations studied and was higher than the uptake of cholesterol. The results of detailed analyses of the lipids recovered from the cells after 6 hours of incubation with the [2,4- 3 H]-15-ketosterol indicated that most of the 3 H was associated with the free 15-ketosterol. Considerably smaller amounts of 3 H were associated with esters of the 15-ketosterol. No conversion of the 15-ketosterol to cholesterol or other C 27 monohydroxysterols was observed. The labeled material with the chromatographic behavior of esters of the 15-ketosterol gave, after mild saponification, the free 15-ketosterol which was characterized by cocrystallization and chromatographic studies. The metabolism of the 15-ketosterol was also studied in male baboons (Papio cynocephalus) treated with the 15-ketosterol. After oral administration of a mixture of [2,4- 3 H]5α-cholest-8(14)-en-3β-ol-15-one and [4- 14 C]cholesterol, blood samples were obtained at various times. Marked differences in the time courses of the levels of 3 H and 14 C in plasma were observed. 3 H showed maximum levels at 4 to 8 h, while maximum values for the levels of 14 C were observed much later. Total lipid extraction of plasma showed that essentially all of the 14 C of plasma was recovered in the lipid extract

Study of the dissolution of uranium nitrides in nitric acid by measuring the isotope ratios, 15N/14N, of the formed products

International Nuclear Information System (INIS)

Hadibi-Olschewski, Nathalie

1991-01-01

The aim of this study was to investigate the dissolution behavior of nitride fuels in nitric acid. The use of nitride fuels in nuclear reactor has many advantages compared with the oxide fuels. One problem in employing nitrides as fuels is the formation of radio-toxic 14 C upon irradiation of natural nitrogen ( 14 N:99.64 pc, 15 N:0.36 pc) in a nuclear reactor ( 14 N (n,p) 14 C reaction). The use of 15 N-enriched fuels avoids these drawbacks. This study was undertaken so as to better understand the mechanisms of the dissolution process and also to follow the distribution of the expensive nitrogen isotope 15 N from the point of view of its behaviour during the recycling process. This study is based on previous work, where the evolution of the nitrogen compounds formed during the dissolution was measured as a function of time for different dissolution parameters. Using 15 N-enriched uranium nitrides or 15 N-enriched nitric acid, two methods were developed to study the influence of the dissolution parameters, nitric acid temperature and concentration, on the 15 N/ 14 N ratios of the nitrogen, nitrogen oxides and ammonium ions utilising a coupled gas-chromatograph/mass spectrometer. The main results are: - similar isotopic composition for NH 4 + and UN; - mixed 14 N/ 15 N composition for N 2 and N 2 O; - similar isotopic composition for NO, NO 2 and HNO 3 ; - no influence of the dissolution parameters on the isotopic composition of the products; an exception maybe made for the N 2 case, which contains more 15 N with increasing acidity and temperature. This work confirms that the first dissolution step is the oxidation of UN with HNO 3 to form NH 4 + and HNO 2 and that HNO 2 has a catalytic role in the dissolution to form other products. And we can conclude that to recycle 15 N, the ammonium ions must be recycled, at least for the case where nitrides are dissolved directly in HNO 3 . (author) [fr

Isotopic ratios D/H and 15N/14N in giant planets

Science.gov (United States)

Marboeuf, Ulysse; Thiabaud, Amaury; Alibert, Yann; Benz, Willy

2018-04-01

The determination of isotopic ratios in planets is important since it allows us to investigate the origins and initial composition of materials. The present work aims to determine the possible range of values for isotopic ratios D/H and 15N/14N in giant planets. The main objective is to provide valuable theoretical assumptions on the isotopic composition of giant planets, their internal structure, and the main reservoirs of species. We use models of ice formation and planet formation that compute the composition of ices and gas accreted in the core and the envelope of planets. Assuming a single initial value for isotopic ratios in volatile species, and disruption of planetesimals in the envelope of gaseous planets, we obtain a wide variety of D/H and 15N/14N ratios in low-mass planets (≤100 Mearth) due to the migration pathway of planets, the accretion time of gas species whose relative abundance evolves with time, and isotope exchanges among species. If giant planets with mass greater than 100 Mearth have solar isotopic ratios such as Jupiter and Saturn due to their higher envelope mass, Neptune-type planets present values ranging between one and three times the solar value. It seems therefore difficult to use isotopic ratios in the envelope of these planets to get information about their formation in the disc. For giant planets, the ratios allow us to constrain the mass fraction of volatile species in the envelope needed to reproduce the observational data by assuming initial values for isotopic ratios in volatile species.

Advanced Physiological Estimation of Cognitive Status. Part 2

Science.gov (United States)

2011-05-24

fatigue, overload) Technology Transfer Opportunity Technology from PDT – Methods to acquire various physiological signals (EEG, EOG , EMG, ECG, etc...Integrated Hardware for Experiments EEG Sensor Array EOG Sensor Array Eye Tracker Amplifiers and Signal Conditioners Laptop Computer...REPORT Advanced Physiological Estimation of Cognitive Status - Part II 14. ABSTRACT 16. SECURITY CLASSIFICATION OF: This report describes ongoing work

A Case of Acute Myeloid Leukemia with a Previously Unreported Translocation (14; 15 (q32; q13

Directory of Open Access Journals (Sweden)

Mohamad Khawandanah

2014-01-01

Full Text Available Background. We hereby describe what we believe to be the first reported case of t (14; 15 (q32; q13 associated with acute myeloid leukemia (AML. Methods. PubMed, Embase, and OVID search engines were used to review the related literature and similar published cases. Case. A47-year-old female presented in December 2011 with AML (acute myelomonocytic leukemia with normal cytogenetics; molecular testing revealed FLT-3 internal tandem duplication (ITD mutation, while no mutations involving FLT3 D385/I836, NPM1 exon 12, or KIT exons 8 and 17 were detected. She was induced with 7 + 3 (cytarabine + idarubicin and achieved complete remission after a second induction with high-dose cytarabine (HiDAC followed by uneventful consolidation. She presented 19 months after diagnosis with relapsed disease. Of note, at relapse cytogenetic analysis revealed t (14; 15 (q32; q13, while FLT-3 analysis showed a codon D835 mutation (no ITD mutation was detected. She proved refractory to the initial clofarabine-based regimen, so FLAG-idarubicin then was used. She continued to have persistent disease, and she was discharged on best supportive care. Conclusion. Based on this single case of AML with t (14; 15 (q32; q13, this newly reported translocation may be associated with refractory disease.

Methodological investigation on the use of 14C-leucine and 15N-leucine for studying the absorption of amino acids in the experimental rat

International Nuclear Information System (INIS)

Bergner, H.; Bergner, U.; Adam, K.

1980-01-01

After nine days of adaptation to a whole-egg diet, albino rats were given 14 C-U-L-leucine and 15 N-L-leucine in addition by the oral route. Each rat received the labelled leucine via a pellet made from the whole-egg diet after food deprivation for 15 h. Thereafter, the experimental animals consumed the unlabelled experimental diet ad libitum. Four times, 30 min, and 1, 2, 4 and 8 h after ingestion of the labelled food, four experimental rats were sacrificed. The contents of the digestive tract and tissue samples were examined for 14 C and 15 N. The halftime of disappearance of the 14 C activity and of the 15 N excess from the TCA-soluble fraction of the gastric contents lay between 1.9 and 2.2 h. Up to the fourth hour of experiment, the 15 N level of the TCA-soluble fraction of the gastric contents was high. The free leucine is obviously absorbed in the stomach and is used for the synthesis of enzyme protein and mucoproteides. In the TCA-soluble fraction of the total contents of the small intestine, the following values (expressed as percentages of the total amounts ingested at the times of measurement) were found: 14 C = 2.0; 6.5; 9.6; 7.4 and 1.5; 15 N excess = 0.8; 1.2; 1.6; 1.6 and 1.2 Were these values regarded as non-absorbed leucine, the 14 C values obtained during the one-to-four hour period of experiment would unequivocally be too high. Presumably, they are simulated by other 14 C-metabolites which originate from the leucine catabolism and reach the intestinal lumen through the intestinal wall. Amino acids labelled with 15 N should be preferred in studies on the absorption of amino acids because, in case of catabolization, the 15 N-amino group is excreted mainly in the form of urea. 14 C-amino acids can be recommended for such studies only if the specific 14 C activity of the amino acid used is also measured. (author)

Single event effects induced by 15.14 MeV/u 136Xe ions

International Nuclear Information System (INIS)

Hou Mingdong; Zhang Qingxiang; Liu Jie; Wang Zhiguang; Jin Yunfan; Zhu Zhiyong; Zhen Honglou; Liu Changlong; Chen Xiaoxi; Wei Xinguo; Zhang Lin; Fan Youcheng; Zhu Zhourong; Zhang Yiting

2002-01-01

Single event effects induced by 15.14 MeV/u 136 Xe ions in different batches of 32k x 8 bits static random access memory are studied. The incident angle dependences of the cross sections for single event upset and single event latch up are presented. The SEE cross sections are plotted versus energy loss instead of linear energy transfer value in sensitive region. The depth of sensitive volume and thickness of 'dead' layer above the sensitive volume are estimated

Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on e-Learning (Madeira, Portugal, July 1-4, 2016)

Science.gov (United States)

Nunes, Miguel Baptista, Ed.; McPherson, Maggie, Ed.

2016-01-01

These proceedings contain the papers of the International Conference e-Learning 2016, which was organised by the International Association for Development of the Information Society, 1-3 July, 2016. This conference is part of the Multi Conference on Computer Science and Information Systems 2016, 1-4 July. The e-Learning (EL) 2016 conference aims…

Densities and viscosities of binary and ternary mixtures of cyclohexanone, 1,4-dioxane and isooctane from T = (288.15 to 313.15) K

International Nuclear Information System (INIS)

Rafiee, Hamid Reza; Ranjbar, Shahram; Poursalman, Fariborz

2012-01-01

Graphical abstract: For binary and ternary mixtures of the following liquids the densities and viscosities have been determined at several temperatures and over the entire range of composition. Also the Δη and excess molar volumes for binary mixtures determined and have been fitted to the Redlich–Kister equation. The interaction parameters, G 12 in the Grunberg–Nissan equation have been found to be negative for all binary mixtures which indicates decreasing the interaction between unlike molecules. Highlights: ► Experimental data for viscosity and density of binary and ternary mixtures reported. ► The considered solvents are Cyclohexanone, 1,4-Dioxane and Isooctane. ► Temperature ranges from 288.15 to 313.15 K and entire range of composition is considered. ► G 12 , in Grunberg–Nissan equation was negative in all binary mixtures at all temperatures. ► V E and Δη for binary mixtures have been fitted to Redlich–Kister equation. - Abstract: Densities and viscosities of binary and ternary mixtures of cyclohexanone, 1,4-dioxane and isooctane have been measured at temperatures from 288.15 K to 313.15 K and over the entire composition range, under atmospheric pressure. From these binary data, the excess molar volumes have been determined and then fitted to Redlich–Kister equation to determine the appropriate coefficients. This work also provides a test of the Grunberg and Nissan equation for correlation the dynamic viscosities of binary mixtures with mole fractions. The interaction parameters for this equation, G 12 were negative for all binary mixtures at different temperatures over entire range of composition which attributed to decreasing the strength of interaction between unlike molecules in mixture.

15-Deoxy-delta12,14-prostaglandin J2, a neuroprotectant or a neurotoxicant?

International Nuclear Information System (INIS)

Koh, Seong-Ho; Jung, Boo; Song, Chi Won; Kim, Youngchul; Kim, Yong Soon; Kim, Seung Hyun

2005-01-01

15-Deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) is a potent ligand for peroxisome proliferators-activated receptor γ (PPARγ). However, its various effects independent of PPARγ have recently been observed. The effect of 15d-PGJ2 on neuronal cells is still controversial. We investigated its effect on neuronal cells (N18D3 cells). When N18D3 cells were treated with 15d-PGJ2, the viability was not changed up to 8 μM, but decreased at higher than 8 μM. The expressions of survival signals, such as p85a phosphatidylinositol 3-kinase, phospho-Akt, and phospho-glycogen synthase kinase-3 beta (Ser-9), slightly increased up to 8 μM, however, decreased at higher than 8 μM. The levels of free radicals and membrane lipid peroxidation and the expression of c-Jun N-terminal Kinase increased in a dose-dependent manner, especially at higher than 8 μM. However, the expressions of death signals, such as cytosolic cytochrome c, activated caspase-3, and cleaved poly(ADP-ribose) polymerase, decreased up to 8 μM, however, increased at higher than 8 μM. In the study to evaluate whether low dose of 15d-PGJ2, up to 8 μM, had protective effect on oxidative stress-injured N18D3 cells, compared to the cells treated with only 100 μM H 2 O 2 , the pretreatment with 8 μM 15d-PGJ2 increased the viability and the expressions of the survival signals, but decreased them of the death signals. These results indicate that 15d-PGJ2 could be a neuroprotectant or a neurotoxicant, depending on its concentration. Therefore, some specific optimum dose of 15d-PGJ2 may be a new potential therapeutic candidate for oxidative stress-injury model of neurodegenerative diseases

Status of physiology education in US Doctor of Pharmacy programs.

Science.gov (United States)

Islam, Mohammed A; Khan, Seher A; Talukder, Rahmat M

2016-12-01

The purpose of the present study was to assess the current status of physiology education in US Doctor of Pharmacy (PharmD) programs. A survey instrument was developed and distributed through SurveyMonkey to American Association of Colleges of Pharmacy (AACP) Biological Sciences section members of 132 PharmD programs. Survey items focused on soliciting qualitative and quantitative information on the delivery of physiology curricular contents and faculty perceptions of physiology education. A total of 114 programs responded to the survey, resulting in a response rate of 86%. Out of 114 schools/colleges, 61 programs (54%) offered standalone physiology courses, and 53 programs (46%) offered physiology integrated with other courses. When integrated, the average contact hours for physiology contents were significantly reduced compared with standalone courses (30 vs. 84 h, P US PharmD programs remains. The reduction of physiology contents is evident when physiology is taught as a component of integrated courses. Given current trends that favor integrated curricula, these data suggest that additional collaboration among basic and clinical science faculty is required to ensure that physiology contents are balanced and not underemphasized in a PharmD curriculum. Copyright © 2016 the American Physiological Society.

Treatment guidelines for Circadian Rhythm Sleep-Wake Disorders of the Polish Sleep Research Society and the Section of Biological Psychiatry of the Polish Psychiatric Association. Part I. Physiology, assessment and therapeutic methods.

Science.gov (United States)

Wichniak, Adam; Jankowski, Konrad S; Skalski, Michal; Skwarło-Sońta, Krystyna; Zawilska, Jolanta B; Żarowski, Marcin; Poradowska, Ewa; Jernajczyk, Wojciech

2017-10-29

Majority of the physiological processes in the human organism are rhythmic. The most common are the diurnal changes that repeat roughly every 24 hours, called circadian rhythms. Circadian rhythms disorders have negative influence on human functioning. The aim of this article is to present the current understanding of the circadian rhythms physiological role, with particular emphasis on the circadian rhythm sleep-wake disorders (CRSWD), principles of their diagnosis and chronobiological therapy. The guidelines are based on the review of recommendations from the scientific societies involved in sleep medicine and the clinical experiences of the authors. Researchers participating in the preparation of guidelines were invited by the Polish Sleep Research Society and the Section of Biological Psychiatry of the Polish Psychiatric Association, based on their significant contributions in circadian rhythm research and/or clinical experience in the treatment of such disorders. Finally, the guidelines were adjusted to the questions and comments given by the members of both Societies. CRSWD have a significant negative impact on human health and functioning. Standard methods used to assess CRSWD are sleep diaries and sleep logs, while the actigraphy, when available, should be also used. The most effective methods of CRSWD treatment are melatonin administration and light therapy. Behavioral interventions are also recommended. Afourteen-day period of sleep-wake rhythm assessment in CRSWD enables accurate diagnosis, adequate selection of chronobiological interventions, and planning adequate diurnal timing of their application. This type of assessment is quite easy, low-cost, and provides valuable indications how to adjust the therapeutic approach to the circadian phase of the particular patient.

Morpho-physiological characterization of Indian wheat genotypes ...

African Journals Online (AJOL)

SAM

2014-05-14

May 14, 2014 ... Key words: Wheat, morphological parameters, physiological growth attributes, proline. INTRODUCTION ... few years, climatic conditions have been drastically changed and ..... Poster presented in the XXVIIIth Meeting of the.

Lyfstraf en martelaarskap in Augustinus se Confessiones 1.9.14-15

Directory of Open Access Journals (Sweden)

Annemare Kotze

2008-01-01

Full Text Available Corporal punishment and martyrdom in Augustine’s Confessiones 1.9.14-15 The article examines a passage from the Confessions in which two instances of violence are introduced. In the course of his autobiographical narration Augustine describes how, as a school boy, he feared corporal punishment and compares it to martyrs’ fear of martyrdom. The first part of the article examines some issues concerning martyrdom and the rivalry that characterized religious life in the 4th century CE and how this may have influenced the world of Augustine and his audience. The second section analyzes the references to corporal punishment in order to illuminate the function of this passage within the context of the autobiographical narration and the overall communicative purpose of the work.

PREFACE: 15th International Conference on Thin Films (ICTF-15)

Science.gov (United States)

Takai, Osamu; Saito, Nagahiro; Zettsu, Nobuyuki; Cho, Sung-Pyo; Terashima, Chiaki; Ueno, Tomonaga; Sakai, Osamu; Miyazaki, Seiichi; Yoshimura, Kazuki; Akamatsu, Kensuke; Ito, Takahiro; Yogo, Toshinobu; Inoue, Yasushi; Ohtake, Naoto; Yoshida, Tsukasa; Tosa, Masahiro; Takai, Madoka; Fujiwara, Yasufumi; Matsuda, Naoki; Teshima, Katsuya; Seki, Takahiro; Matsunaga, Katsuyuki; Fujita, Daisuke

2013-03-01

The International Conference on Thin Films is the most established conference for all researchers and persons interested in thin films and coatings. It is one of the tri-annual conference series endorsed and co-organized by the Thin Film Division of the International Union for Vacuum Science, Technique and Applications (IUVSTA), a union of national member societies whose role is to stimulate international collaboration in the fields of vacuum science, techniques and applications and related multi-disciplinary topics including solid-vacuum and other interfaces. The 15th International Conference on Thin Films (ICTF-15) is organized by The Vacuum Society of Japan (VSJ) and held at Kyoto TERRSA in Kyoto, Japan on 8-11 November 2011, following the 14th International Conference on Thin Films (ICTF-14), which was held in Ghent, Belgium in 2008. Thin films and coatings are daily becoming increasingly important in the fields of various industries. This International Conference provides a multi-disciplinary forum for recent advances in basic research, development and applications of thin films and coatings. This conference will present a unique opportunity for researchers, engineers and managers to acquire new knowledge of thin films and coatings. We hope that our understanding on thin films and coatings will be deepened through this conference. The conference site, 'Kyoto TERRSA' is located in the historical heart of the old capital Kyoto. Kyoto is an ancient city with a 1200-year history. It was established as Japan's capital under the name 'Heian-kyo' in the year 794. Although many transformations have taken place over the years, Kyoto has always embraced the most advanced standards of the times. It has greatly contributed to the nation's industrial, economic and cultural development. The dauntless spirit of leadership of Kyoto's past as a capital city is still felt here today. Kyoto also preserves the beloved examples of its culture as testimonials of time. This is shown

Cyclopentenone prostaglandins as potential inducers of phase II detoxification enzymes. 15-deoxy-delta(12,14)-prostaglandin j2-induced expression of glutathione S-transferases.

Science.gov (United States)

Kawamoto, Y; Nakamura, Y; Naito, Y; Torii, Y; Kumagai, T; Osawa, T; Ohigashi, H; Satoh, K; Imagawa, M; Uchida, K

2000-04-14

Exposure of cells to a wide variety of chemoprotective compounds confers resistance to a broad set of carcinogens. For a subset of the chemoprotective compounds, protection is generated by an increase in the abundance of protective enzymes, such as glutathione S-transferases (GSTs). In the present study, we developed a cell culture system that potently responds to phenolic antioxidants and found that antitumor prostaglandins (PGs) are potential inducers of GSTs. We screened primary hepatocytes and multiple cell lines for inducing GST activity upon incubation with the phenolic antioxidant (tert-butylhydroquinone) and found that rat liver epithelial RL34 cells most potently responded. Based on an extensive screening of diverse chemical agents on the induction of GST activity in RL34 cells, the J2 series of PGs, 15-deoxy-Delta(12,14)-prostaglandin J2 (15-deoxy-Delta(12,14)-PGJ2) in particular, were found to be potential inducers of GST. Enhanced gene expression of Class pi GST isozyme (GSTP1) by 15-deoxy-Delta(12,14)-PGJ2 was evident as a drastic elevation of the mRNA level. Hence, we examined the molecular mechanism underlying the 15-deoxy-Delta(12, 14)-PGJ2-induced GSTP1 gene expression. From functional analysis of various deletion mutant genes, we found that the 15-deoxy-Delta(12, 14)-PGJ2 reponse element was localized in a region containing a GSTP1 enhancer I (GPEI) that consists of two imperfect phorbol 12-O-tetradecanoylphorbol-13-acetate response elements. When the GPEI was combined with the minimum GSTP1 promoter, the element indeed showed an enhancer activity in response to 15-deoxy-Delta(12, 14)-PGJ2. Point mutations of either of the two imperfect 12-O-tetradecanoylphorbol-13-acetate response elements in GPEI completely abolished the enhancer activity. Gel mobility shift assays demonstrated that 15-deoxy-Delta(12,14)-PGJ2 specifically stimulated the binding of nuclear proteins including the transcription factor c-Jun, but not Nrf2, to GPEI. These results

31. Congress and 15. Advanced course of the European Society of Neuroradiology. Abstracts

International Nuclear Information System (INIS)

Anon.

2006-01-01

The European Society of Neuroradiology (ESNR) was founded on September 5, 1969 during a meeting which took place in Colmar, France, upon the initiative of Drs Jean-Paul Braun (Colmar) and Auguste Wackenheim (Strasbourg) and under the guidance and support of Professor George B. Ziedses des Plantes (Amsterdam). The following purposes of the Society were unanimously adopted by the 68 Founding Members: 1. To promote Neuroradiology by appropriate means. 2. To co-ordinate work and documents in Neuroradiology and to assure their diffusion throughout the countries of Europe. 3. To co-ordinate the relationships between General Radiology and the Clinical Neurosciences. 4. To contribute toward unified methods of teaching Neuroradiology and unified standards for training and certification in Neuroradiology. 5. To promote and co-ordinate relationships among the European National Neuroradiological Societies and to promote the foundation of National Neuroradiological Societies. 6. To form European research teams to deal with specific neuroradiological questions. (orig.)

November 2017 Arizona thoracic society notes

Directory of Open Access Journals (Sweden)

Robbins RA

2017-11-01

Full Text Available No abstract available. Article truncated after 150 words. The November 2017 Arizona Thoracic Society meeting was held on Wednesday, November 15, 2017 at the HonorHealth Rehabilitation Hospital beginning at 6:30 PM. This was a dinner meeting with a lecture followed by case presentations. There were 15 in attendance representing the pulmonary, critical care, sleep, allergy, infectious disease and radiology communities. At the beginning of the meeting several issues were discussed: 1. CME offered by the Southwest Journal of Pulmonary and Critical Care Medicine (SWJPCC is currently offered to only the Southwest state thoracic societies and the Mayo Clinic. After discussion it was felt that this restriction of access was no longer appropriate and CME credits should be available to all. 2. Efforts continue to obtain CME for the Arizona Thoracic Society meetings. Our Chapter Representative, Dr. Gerry Schwartzberg, is approaching this with the American Thoracic Society. Locally, HonorHealth sent out a survey on CME needs. Members were encouraged …

15 CFR 14.41 - Recipient responsibilities.

Science.gov (United States)

2010-01-01

... violation of statute are to be referred to such Federal, State or local authority as may have proper... COMMERCIAL ORGANIZATIONS Post-Award Requirements Procurement Standards § 14.41 Recipient responsibilities... responsibilities arising under its contract(s). The recipient is the responsible authority, without recourse to the...

15 CFR 14.27 - Allowable costs.

Science.gov (United States)

2010-01-01

... GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, OTHER NON-PROFIT, AND COMMERCIAL ORGANIZATIONS Post-Award Requirements Financial and Program Management § 14.27 Allowable costs. For each kind of... Organizations.” The allowability of costs incurred by institutions of higher education is determined in...

Primary Prevention of Cervical Cancer: American Society of Clinical Oncology Resource-Stratified Guideline

Directory of Open Access Journals (Sweden)

Silvina Arrossi

2017-10-01

Full Text Available Purpose: To provide resource-stratified (four tiers, evidence-based recommendations on the primary prevention of cervical cancer globally. Methods: The American Society of Clinical Oncology convened a multidisciplinary, multinational panel of oncology, obstetrics/gynecology, public health, cancer control, epidemiology/biostatistics, health economics, behavioral/implementation science, and patient advocacy experts. The Expert Panel reviewed existing guidelines and conducted a modified ADAPTE process and a formal consensus-based process with additional experts (consensus ratings group for one round of formal ratings. Results: Existing sets of guidelines from five guideline developers were identified and reviewed; adapted recommendations formed the evidence base. Five systematic reviews, along with cost-effectiveness analyses, provided evidence to inform the formal consensus process, which resulted in agreement of ≥ 75%. Recommendations: In all resource settings, two doses of human papillomavirus vaccine are recommended for girls age 9 to 14 years, with an interval of at least 6 months and possibly up to 12 to 15 months. Individuals with HIV positivity should receive three doses. Maximal and enhanced settings: if girls are age ≥ 15 years and received their first dose before age 15 years, they may complete the series; if no doses were received before age 15 years, three doses should be administered; in both scenarios, vaccination may be through age 26 years. Limited and basic settings: if sufficient resources remain after vaccinating girls age 9 to 14 years, girls who received one dose may receive additional doses between age 15 and 26 years. Maximal, enhanced, and limited settings: if ≥ 50% coverage in the priority female target population, sufficient resources, and cost effectiveness, boys may be vaccinated to prevent other noncervical human papillomavirus–related cancers and diseases. Basic settings: vaccinating boys is not recommended

Primary Prevention of Cervical Cancer: American Society of Clinical Oncology Resource-Stratified Guideline.

Science.gov (United States)

Arrossi, Silvina; Temin, Sarah; Garland, Suzanne; Eckert, Linda O'Neal; Bhatla, Neerja; Castellsagué, Xavier; Alkaff, Sharifa Ezat; Felder, Tamika; Hammouda, Doudja; Konno, Ryo; Lopes, Gilberto; Mugisha, Emmanuel; Murillo, Rául; Scarinci, Isabel C; Stanley, Margaret; Tsu, Vivien; Wheeler, Cosette M; Adewole, Isaac Folorunso; de Sanjosé, Silvia

2017-10-01

To provide resource-stratified (four tiers), evidence-based recommendations on the primary prevention of cervical cancer globally. The American Society of Clinical Oncology convened a multidisciplinary, multinational panel of oncology, obstetrics/gynecology, public health, cancer control, epidemiology/biostatistics, health economics, behavioral/implementation science, and patient advocacy experts. The Expert Panel reviewed existing guidelines and conducted a modified ADAPTE process and a formal consensus-based process with additional experts (consensus ratings group) for one round of formal ratings. Existing sets of guidelines from five guideline developers were identified and reviewed; adapted recommendations formed the evidence base. Five systematic reviews, along with cost-effectiveness analyses, provided evidence to inform the formal consensus process, which resulted in agreement of ≥ 75%. In all resource settings, two doses of human papillomavirus vaccine are recommended for girls age 9 to 14 years, with an interval of at least 6 months and possibly up to 12 to 15 months. Individuals with HIV positivity should receive three doses. Maximal and enhanced settings: if girls are age ≥ 15 years and received their first dose before age 15 years, they may complete the series; if no doses were received before age 15 years, three doses should be administered; in both scenarios, vaccination may be through age 26 years. Limited and basic settings: if sufficient resources remain after vaccinating girls age 9 to 14 years, girls who received one dose may receive additional doses between age 15 and 26 years. Maximal, enhanced, and limited settings: if ≥ 50% coverage in the priority female target population, sufficient resources, and cost effectiveness, boys may be vaccinated to prevent other noncervical human papillomavirus-related cancers and diseases. Basic settings: vaccinating boys is not recommended. It is the view of the American Society of Clinical Oncology that

FISH PHYSIOLOGY, TOXICOLOGY, AND WATER QUALITY:

Science.gov (United States)

Twenty-one participants from Europe, North America and China convened in Chongqing, China, October 12-14, 2005, for the Eighth International Symposium in Fish Physiology, Toxicology and Water Quality. The subject of the meeting was "Hypoxia in vertebrates: Comparisons of terrestr...

The analysis of 15N/14N ratios in natural samples, with emphasis on nitrate and ammonium in precipitation

International Nuclear Information System (INIS)

Heaton, T.H.E.; Collett, G.M.

1985-01-01

The nitrogen cycle is one of the most important of the earth's elemental cycles. The report describes the procedures used for the analysis of 15 N/ 14 N ratios in ammonium and nitrate (and organic nitrogen), and summaries without discussion the data obtained for precipitation (by rain and dust) collected at the Council for Scientific and Industrial Research site. The 15 N/ 14 N ratios of nitrogen compounds were determined on N2 gas. This was measured by means of a mass spectrometer. The isotopic analysis of organic nitrogen were conducted in two ways: Kjeldahl digestion to form ammonium, and Dumas combustion directly to N2

Sterol synthesis. A novel reductive rearrangement of an alpha,beta-unsaturated steroidal epoxide; a new chemical synthesis of 5alpha-cholest-8(14)-en-3beta, 15alpha-diol.

Science.gov (United States)

Parish, E J; Schroepfer, G J

1977-04-01

Reduction of 3beta-benzoyloxy-14alpha,15alpha-epoxy-5alpha-cholest-7-ene with either lithium triethylboro-hydride or lithium aluminum hydride (4 molar excess) gave 5-alpha-cholest-8(14)-en-3beta,15alpha-diol in high yield. Reduction of the epoxy ester with lithium triethylborodeuteride or lithium aluminum deuteride (4 molar excess) gave [7alpha-2-H]-5alpha-cholest-8(14)-en-3beta,15alpha-diol. Reduction of 2beta-benzoyloxy-14alpha,15alpha-epoxy-5alpha-cholest-7-ene with a large excess (24 molar excess) of lithium aluminum hydride gave, in addition to the expected 5alpha-cholest-8(14)-en-3beta,15alpha-diol, a significant yield (33%) of 5alpha-cholest-8(14)-en-3beta-o1. Reduction of the epoxy ester with a large excess (24 molar excess) of lithium aluminum deuteride gave [7alpha-2H]-5alpha-cholest-8(14)-en-3beta,15alpha-diol and 5alpha-cholest-8(14)-en-3beta-o1 which contained two atoms of stably bound deuterium.

Assessment of off-stoichiometric Zr33-xFe52+xSi15 C14 Laves phase compounds as permanent magnet materials

Science.gov (United States)

Gabay, A. M.; Hadjipanayis, G. C.

2018-05-01

Recently, Fe-based rare-earth-free compounds with non-cubic crystal structures were proposed as a base for permanent magnets which would not rely on critical elements. In this work, two series of alloys, Zr27Fe73-wSiw (0 ≤ w ≤ 15) and Zr33-xFe52+xSi15 (0 ≤ x ≤ 11), were prepared and characterized after annealing at 1538 K in order to determine the fundamental magnetic properties of the C36 and C14 hexagonal Laves phase compounds. A mixture of the cubic C15 and Zr6Fe23 structures was observed instead of the expected C36 structure. The hexagonal C14 was found in all Zr33-xFe52+xSi15 alloys with its lattice parameters linearly decreasing as the Fe(Si) atoms occupy the Zr sites in the Laves phase crystal structure. The solubility limit of Fe in the C14 structure at 1538 K corresponds to x = 9.5. The Curie temperature of the C14 compounds increases with deviation from the Laves phase stoichiometry from 290 K to 530 K. The room-temperature spontaneous magnetization also increases reaching, after correcting for the non-magnetic impurities, a value of 6.7 kG. The magnetocrystalline anisotropy of the off-stoichiometric C14 Laves phase was found to be uniaxial with the easy magnetization direction parallel to the hexagonal axis. Unfortunately, the anisotropy field, which does not exceed 10 kOe, is not sufficiently high to make the compounds interesting as permanent magnet materials.

XXII annual meeting of the Spanish Nuclear Society, Santander 22-26 October 1996: program and synopsis of lectures

International Nuclear Information System (INIS)

1996-01-01

The technical sessions of XXII annual meeting of the Spanish Nuclear Society were: 1) Fusion 2) Engineering: calculation and simulation. 3) Economical, legal and social aspect 4) Plant life extension 5) Operating experiences, refueling and operation support 9)Probabilistic safety 7) radiological protection 8) Waste management 9) Maintenance 10) Advanced plants 11) Steam generators 12) Nuclear Safety. R and D 13) Environmental aspects 14) Fuel 15) Quality

Artifact suppression in electron paramagnetic resonance imaging of 14N- and 15N-labeled nitroxyl radicals with asymmetric absorption spectra

Science.gov (United States)

Takahashi, Wataru; Miyake, Yusuke; Hirata, Hiroshi

2014-10-01

This article describes an improved method for suppressing image artifacts in the visualization of 14N- and 15N-labeled nitroxyl radicals in a single image scan using electron paramagnetic resonance (EPR). The purpose of this work was to solve the problem of asymmetric EPR absorption spectra in spectral processing. A hybrid function of Gaussian and Lorentzian lineshapes was used to perform spectral line-fitting to successfully separate the two kinds of nitroxyl radicals. This approach can process the asymmetric EPR absorption spectra of the nitroxyl radicals being measured, and can suppress image artifacts due to spectral asymmetry. With this improved visualization method and a 750-MHz continuous-wave EPR imager, a temporal change in the distributions of a two-phase paraffin oil and water/glycerin solution system was visualized using lipophilic and hydrophilic nitroxyl radicals, i.e., 2-(14-carboxytetradecyl)-2-ethyl-4,4-dimethyl-3-oxazolidinyloxy (16-DOXYL stearic acid) and 4-hydroxyl-2,2,6,6-tetramethylpiperidine-d17-1-15N-1-oxyl (TEMPOL-d17-15N). The results of the two-phase separation experiment verified that reasonable artifact suppression could be achieved by the present method that deals with asymmetric absorption spectra in the EPR imaging of 14N- and 15N-labeled nitroxyl radicals.

HBK-14 and HBK-15 Do Not Influence Blood Pressure, Lipid Profile, Glucose Level, or Liver Enzymes Activity after Chronic Treatment in Rats.

Science.gov (United States)

Pytka, Karolina; Głuch-Lutwin, Monika; Knutelska, Joanna; Jakubczyk, Magdalena; Waszkielewicz, Anna; Kotańska, Magdalena

2016-01-01

Older and even new antidepressants cause adverse effects, such as orthostatic hypotension, hyper- or hypoglycemia, liver injury or lipid disorders. In our previous experiments we showed significant antidepressant- and anxiolytic-like activities of dual 5-HT1A and 5-HT7 antagonists with α1-adrenolitic properties i.e. 1-[(2,6-dimethylphenoxy)ethoxyethyl]-4-(2-methoxyphenyl)piperazine hydrochloride (HBK-14) and 1-[(2-chloro-6-methylphenoxy)ethoxyethyl]-4-(2-methoxyphenyl)piperazine hydrochloride (HBK-15). Here, we evaluated the influence of chronic administration of HBK-14 and HBK-15 on blood pressure (non-invasive blood pressure measurement system for rodents), lipid profile (total cholesterol, low density lipoproteins-LDL, high density lipoproteins-HDL, triglycerides), glucose level, and liver enzymes activity (aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transferase). We determined potential antihistaminic (isolated guinea pig ileum) and antioxidant properties (ferric reducing ability of plasma-FRAP, non-protein thiols-NPSH, stable free radical diphenylpicrylhydrazyl-DPPH) cytotoxicity. Our experiments revealed that HBK-14 and HBK-15 did not influence blood pressure, lipid profile, glucose level or liver enzymes activity in rats after 2-week treatment. We also showed that none of the compounds possessed antioxidant or cytotoxic properties at antidepressant- and anxiolytic-like doses. HBK-14 and HBK-15 very weakly blocked H1 receptors in guinea pig ileum. Positive results of our preliminary experiments on the safety of HBK-14 and HBK-15 encourage further studies concerning their effectiveness in the treatment of depression and/or anxiety disorders.

HBK-14 and HBK-15 Do Not Influence Blood Pressure, Lipid Profile, Glucose Level, or Liver Enzymes Activity after Chronic Treatment in Rats.

Directory of Open Access Journals (Sweden)

Karolina Pytka

Full Text Available Older and even new antidepressants cause adverse effects, such as orthostatic hypotension, hyper- or hypoglycemia, liver injury or lipid disorders. In our previous experiments we showed significant antidepressant- and anxiolytic-like activities of dual 5-HT1A and 5-HT7 antagonists with α1-adrenolitic properties i.e. 1-[(2,6-dimethylphenoxyethoxyethyl]-4-(2-methoxyphenylpiperazine hydrochloride (HBK-14 and 1-[(2-chloro-6-methylphenoxyethoxyethyl]-4-(2-methoxyphenylpiperazine hydrochloride (HBK-15. Here, we evaluated the influence of chronic administration of HBK-14 and HBK-15 on blood pressure (non-invasive blood pressure measurement system for rodents, lipid profile (total cholesterol, low density lipoproteins-LDL, high density lipoproteins-HDL, triglycerides, glucose level, and liver enzymes activity (aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transferase. We determined potential antihistaminic (isolated guinea pig ileum and antioxidant properties (ferric reducing ability of plasma-FRAP, non-protein thiols-NPSH, stable free radical diphenylpicrylhydrazyl-DPPH cytotoxicity. Our experiments revealed that HBK-14 and HBK-15 did not influence blood pressure, lipid profile, glucose level or liver enzymes activity in rats after 2-week treatment. We also showed that none of the compounds possessed antioxidant or cytotoxic properties at antidepressant- and anxiolytic-like doses. HBK-14 and HBK-15 very weakly blocked H1 receptors in guinea pig ileum. Positive results of our preliminary experiments on the safety of HBK-14 and HBK-15 encourage further studies concerning their effectiveness in the treatment of depression and/or anxiety disorders.

The focus of women in The American Fertility Society.

Science.gov (United States)

Haseltine, F P; Wentz, A C

1984-09-01

This article reports survey responses from 71 female members of the American Fertility Society during the Society's 1984 annual meeting. Survey questions concern 1) demographic factors such as rank, degree, title, address, and number of children, 2) field of specialization and research interests, and 3) what the Society can do for its meeting participants. The typical respondent is a physician living in the Eastern United States and employed as an assistant professor in an academic setting. In vitro fertilization is the greatest area of interest, followed by general practice, endocrine and male infertility, contraception, and fertility surgery. Survey responses show that women are interested in 1) networking, 2) increased visibility at professional meetings, 3) information about research possibilities and grants, 4) child care provision at Society meetings, and 5) more basic science and physiology oriented presentions in the program. In response to networking interests, the Society will make available information from the surveyed members. Since 16% of respondents have a PH.D., and 77% are employed in academics, the Society should consider more basic presentations. The need for day care indicates changes in Society membership. The Society plans to conduct similar surveys on a regular basis.

Global Pc 5 event of November 14--15, 1979

International Nuclear Information System (INIS)

Higbie, P.R.; Baker, D.N.; Zwickl, R.D.; Belian, R.D.; Asbridge, J.R.; Fennell, J.F.; Wilken, B.; Arthur, C.W.

1982-01-01

Large-amplitude Pc 5 waves with 7--8 min quasi-periodic variations were observed almost continuously for the 48 hours of November 14--15, 1979, by several spacecraft in or near geostationary orbit on the dayside portions of their orbits. The waves were observed as large modulations in both the electron and ion fluxes over a wide range of energies (approx.1 to 500 keV) by the spacecraft 1976--059, 1977-007, 1979-053, P78-2, and GEOS 2 and as magnetic field peak-to-peak modulations of 15--25 γ by the P78-2 and GOES 2 and 3 magnetometers. The remarkably long persistence of these waves contrasts substantially with observations of typical flux modulation events which usually last less than 1 hour and which typically show little modulation of the > or =150 keV proton fluxes. Data taken concurrently by the ISEE spacecraft in the solar wind and outer magnetosphere indicate that the solar wind also had unusually properties. ISEE 3 measurements indicate that the solar wind velocity (approx.350 km/s) and density (approx.2 cm -3 ) were simultaneously very low for this period. The alpha-to-proton ratio for the solar wind plasma attained an extremely low value (<1%) early in the event. These solar wind properties imply such a much reduced dynamic pressure on the magnetosphere during this period. Consequently, the ISEE 1 and 2 spacecraft passed through the magnetopause at the uncommonly large radial distance of 18 R/sub E/ at approx.0830 local time where the typical magnetopause geocentric distance is 12 R/sub E/. The exceptional solar wind and outer magnetospheric conditions may have determined the unusual properties of the ULF event observed near geostationary orbit. Some candidate mechanisms for producing these oscillations are presented, but no definitive explanation for this event can be given at present

Society and Environment Interaction. The Environment of the Laguna de los Tollos (Western Andalusia, 13th-15th Centuries

Directory of Open Access Journals (Sweden)

Emilio MARTÍN GUTIÉRREZ

2014-12-01

Full Text Available Environment of the Laguna de los Tollos is studied between 13th and 15th Centuries. The research, which aims to analyse the interaction environment-society, is part of a project that will deepen the knowledge of wetlands in this geographical area. In these ecosystems rural communities took advantage with their farmland for hunting, herding, fishing and gathering resources in riparian areas. The chosen chronological period includes a wide range of changes that had a direct impact on the management and organization of rural landscapes.

Elastic electron scattering from 14N, 15N, 16O and 18O at small momentum transfer

International Nuclear Information System (INIS)

Schuetz, W.

1973-01-01

At the Darmstadt linear accelerator, cross-sections for the elastic scattering of electrons on 14 N and 16 O relative to the proton and on 15 N and 18 O relative to 14 N and 16 O were measured at energies 30 MeV 0 0 (q 2 -2 ). The experiments were done with gas targets, the target containers being thin-walled aluminium cylinders. The data were evaluated by means of the partial-wave method assuming a charge distribution according to the shell model. (orig./WL) [de

Clinical and molecular characterization of two patients with overlapping de novo microdeletions in 2p14-p15 and mild mental retardation

DEFF Research Database (Denmark)

Wohlleber, Eva; Kirchhoff, Eva Maria; Zink, Alexander M

2011-01-01

Here, we present two patients with overlapping de novo microdeletions in chromosome 2p14-p15, mild mental retardation concerning especially language development, as well as mild dysmorphic features. Patient 1 also presented with generalized seizures, sensorineural hearing loss, and relative...... microcephaly. In patient 1, molecular karyotyping detected a 2.23-Mb deletion in chromosome 2p14-p15 including 11 known genes. The second patient, with a 2.84-Mb microdeletion containing 15 genes, was identified in the DECIPHER database. The two deleted regions overlap by a stretch of 1.6 Mb that contains 10...

A history of the American Society for Clinical Investigation

Science.gov (United States)

Howell, Joel D.

2009-01-01

One hundred years ago, in 1909, the American Society for Clinical Investigation (ASCI) held its first annual meeting. The founding members based this new society on a revolutionary approach to research that emphasized newer physiological methods. In 1924 the ASCI started a new journal, the Journal of Clinical Investigation. The ASCI has also held an annual meeting almost every year. The society has long debated who could be a member, with discussions about whether members must be physicians, what sorts of research they could do, and the role of women within the society. The ASCI has also grappled with what else the society should do, especially whether it ought to take a stand on policy issues. ASCI history has reflected changing social, political, and economic contexts, including several wars, concerns about the ethics of biomedical research, massive increases in federal research funding, and an increasingly large and specialized medical environment. PMID:19348041

Insomnia with physiological hyperarousal is associated with hypertension.

Science.gov (United States)

Li, Yun; Vgontzas, Alexandros N; Fernandez-Mendoza, Julio; Bixler, Edward O; Sun, Yuanfeng; Zhou, Junying; Ren, Rong; Li, Tao; Tang, Xiangdong

2015-03-01

Previous studies have suggested that insomnia with objective short sleep duration is associated with a higher risk of hypertension, and it has been speculated that the underlying mechanism is physiological hyperarousal. In this study, we tested whether insomnia with physiological hyperarousal measured by Multiple Sleep Latency Test (MSLT), a standard test of sleepiness/alertness, is associated with increased risk of hypertension. Two hundred nineteen chronic insomniacs and 96 normal sleepers were included in this study. Chronic insomnia was defined based on standard diagnostic criteria with symptoms lasting ≥6 months. All subjects underwent 1 night in laboratory polysomnography followed by a standard MSLT. We used the median mean MSLT value (ie, >14 minutes) and the 75th percentile of mean MSLT value (ie, >17 minutes) to define hyperarousal. Hypertension was defined based either on blood pressure measures or on diagnosis treatment by a physician. After controlling for age, sex, body mass index, apnea-hypopnea index, diabetes mellitus, smoking, alcohol, and caffeine use, insomnia combined with MSLT >14 minutes increased the odds of hypertension by 300% (odds ratio=3.27; 95% confidence interval=1.20-8.96), whereas insomnia combined with MSLT >17 minutes increased even further the odds of hypertension by 400% (odds ratio=4.33; 95% confidence interval=1.48-12.68) compared with normal sleepers with MSLT ≤14 minutes. Insomnia associated with physiological hyperarousal is associated with a significant risk of hypertension. Long MSLT values may be a reliable index of the physiological hyperarousal and biological severity of chronic insomnia. © 2015 American Heart Association, Inc.

A molecular concept of caste in insect societies.

Science.gov (United States)

Sumner, Seirian; Bell, Emily; Taylor, Daisy

2018-02-01

The term 'caste' is used to describe the division of reproductive labour that defines eusocial insect societies. The definition of 'caste' has been debated over the last 50 years, specifically with respect to the simplest insect societies; this raises the question of whether a simple categorisation of social behaviour by reproductive state alone is helpful. Gene-level analyses of behaviours of individuals in hymenopteran social insect societies now provide a new empirical base-line for defining caste and understanding the evolution and maintenance of a reproductive division of labour. We review this literature to identify a set of potential molecular signatures that, combined with behavioural, morphological and physiological data, help define caste more precisely; these signatures vary with the type of society, and are likely to be influenced by ecology, life-history, and stage in the colony cycle. We conclude that genomic approaches provide us with additional ways to help quantify and categorise caste, and behaviour in general. Copyright © 2017 Elsevier Inc. All rights reserved.

THE 3rd SCHIZOPHRENIA INTERNATIONAL RESEARCH SOCIETY CONFERENCE, 14-18 APRIL 2012, FLORENCE, ITALY: SUMMARIES OF ORAL SESSIONS

Science.gov (United States)

Abbs, Brandon; Achalia, Rashmin M; Adelufosi, Adegoke O; Aktener, Ahmet Yiğit; Beveridge, Natalie J; Bhakta, Savita G; Blackman, Rachael K; Bora, Emre; Byun, MS; Cabanis, Maurice; Carrion, Ricardo; Castellani, Christina A; Chow, Tze Jen; Dmitrzak-Weglarz, M; Gayer-Anderson, Charlotte; Gomes, Felipe V; Haut, Kristen; Hori, Hiroaki; Kantrowitz, Joshua T; Kishimoto, Taishiro; Lee, Frankie HF; Lin, Ashleigh; Palaniyappan, Lena; Quan, Meina; Rubio, Maria D; Ruiz de Azúa, Sonia; Sahoo, Saddichha; Strauss, Gregory P; Szczepankiewicz, Aleksandra; Thompson, Andrew D; Trotta, Antonella; Tully, Laura M; Uchida, Hiroyuki; Velthorst, Eva; Young, Jared W; O’Shea, Anne; DeLisi, Lynn E.

2013-01-01

The 3rd Schizophrenia International Research Society Conference was held in Florence, Italy, April 14-18, 2012.and this year had as its emphasis, “The Globalization of Research”. Student travel awardees served as rapporteurs for each oral session and focused their summaries on the most significant findings that emerged and the discussions that followed. The following report is a composite of these summaries. We hope that it will provide an overview for those who were present, but could not participate in all sessions, and those who did not have the opportunity to attend, but who would be interested in an update on current investigations ongoing in the field of schizophrenia research. PMID:22910407

Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Cognition and Exploratory Learning in Digital Age (14th, Vilamoura, Algarve, Portugal, October 18-20, 2017)

Science.gov (United States)

Sampson, Demetrios G., Ed.; Spector, J. Michael, Ed.; Ifenthaler, Dirk, Ed.; Isaías, Pedro, Ed.

2017-01-01

These proceedings contain the papers of the 14th International Conference on Cognition and Exploratory Learning in the Digital Age (CELDA 2017), 18-20 October 2017, which has been organized by the International Association for Development of the Information Society (IADIS) and endorsed by the Japanese Society for Information and Systems in…

Conformational properties of 1,4- and 1,5-substituted 1,2,3-triazole amino acids – building units for peptidic foldamers

KAUST Repository

Kann, Nina; Johansson, Johan R.; Beke-Somfai, Tamá s

2015-01-01

© The Royal Society of Chemistry 2015. Peptidic foldamers have recently emerged as a novel class of artificial oligomers with properties and structural diversity similar to that of natural peptides, but possessing additional interesting features granting them great potential for applications in fields from nanotechnology to pharmaceuticals. Among these, foldamers containing 1,4- and 1,5-substitued triazole amino acids are easily prepared via the Cu- and Ru-catalyzed click reactions and may offer increased side chain variation, but their structural capabilities have not yet been widely explored. We here describe a systematic analysis of the conformational space of the two most important basic units, the 1,4-substitued (4Tzl) and the 1,5-substitued (5Tzl) 1,2,3-triazole amino acids, using quantum chemical calculations and NMR spectroscopy. Possible conformations of the two triazoles were scanned and their potential minima were located using several theoretical approaches (B3LYP/6-311++G(2d,2p), ωB97X-D/6-311++G(2d,2p), M06-2X/6-311++G(2d,2p) and MP2/6-311++G(2d,2p)) in different solvents. BOC-protected versions of 4Tzl and 5Tzl were also prepared via one step transformations and analyzed by 2D NOESY NMR. Theoretical results show 9 conformers for 5Tzl derivatives with relative energies lying close to each other, which may lead to a great structural diversity. NMR analysis also indicates that conformers preferring turn, helix and zig-zag secondary structures may coexist in solution. In contrast, 4Tzl has a much lower number of conformers, only 4, and these lack strong intraresidual interactions. This is again supported by NMR suggesting the presence of both extended and bent conformers. The structural information provided on these building units could be employed in future design of triazole foldamers. This journal is

Effects of preoperative administration of butorphanol or meloxicam on physiologic responses to surgery in ball pythons.

Science.gov (United States)

Olesen, Mette G; Bertelsen, Mads F; Perry, Steve F; Wang, Tobias

2008-12-15

To characterize physiologic responses of ball pythons (Python regius) following a minor surgical procedure and investigate the effects of 2 commonly used analgesics on this response. 15 healthy ball pythons. Snakes were randomly assigned to receive 1 of 3 treatments: meloxicam (0.3 mg/kg [0.14 mg/lb]; n = 5), butorphanol (5 mg/kg [2.3 mg/lb]; 5), or saline (0.9% NaCl) solution (5) before catheterization of the vertebral artery. Plasma concentrations of catecholamines and cortisol, blood pressure, heart rate, and blood gas values were measured at various times for 72.5 hours after catheterization. The 72.5-hour point was defined as baseline. Heart rate of ball pythons increased significantly during the first hour following surgery. Mean plasma epinephrine concentration increased slightly at 2.5 hours after surgery, whereas mean plasma cortisol concentration increased beginning at 1.5 hours, reaching a maximum at 6.5 hours. Mean blood pressure increased within the first hour but returned to the baseline value at 2.5 hours after surgery. After 24.5 hours, blood pressure, heart rate, and plasma hormone concentrations remained stable at baseline values. There were no significant differences in values for physiologic variables between snakes that received saline solution and those that received meloxicam or butorphanol. Measurement of physiologic variables provides a means of assessing postoperative pain in snakes. Meloxicam and butorphanol at the dosages used did not decrease the physiologic stress response and did not appear to provide analgesic effects in ball pythons.

Measurements of the interaction cross-sections for 14Be and 14,15B as projectiles with a new scheme at RIBLL

International Nuclear Information System (INIS)

Ozawa, A.; Cai, Y.Z.; Chen, Z.Q.; Chiba, M.; Fang, D.Q.; Guo, Z.G.; Izumikawa, T.; Li, J.X.; Mao, R.S.; Ohnishi, T.; Shen, W.Q.; Suda, T.; Sun, Z.Y.; Suzuki, T.; Tanihata, I.; Tian, W.D.; Wang, J.S.; Wang, M.; Wei, Y.B.; Xiao, G.Q.; Xiao, Z.G.; Yamaguchi, T.; Yamaguchi, Y.; Yoshida, A.; Zhan, W.L.; Zhang, H.Y.; Zheng, T.; Zhong, C.

2006-01-01

We have measured the interaction cross-sections (σ I ) for light neutron-rich nuclei ( 14 Be, 14,15 B) at ∼50A MeV at the Radioactive Ion Beam Line in Lanzhou (RIBLL) in IMP with a new scheme. In this scheme, a carbon reaction target was installed at the intermediate focusing point at RIBLL. This scheme allowed us to identify particles before and after the reaction target unambiguously. However, this scheme might suffer a large loss of transmission efficiency in the second half of RIBLL. We checked this effect by changing the emittance of the RI beams. The results showed that a correction of the transmission efficiency is needed to deduce σ I . We performed a Monte Carlo type simulation and tried to deduce σ I for the above nuclei. Finally, we obtained reasonable σ I although their error bars were fairly large. The results were compared with calculations by an energy-dependent semi-empirical formula

Character strengths, social anxiety, and physiological stress reactivity

Directory of Open Access Journals (Sweden)

Tingting Li

2017-05-01

Full Text Available In this paper, the effects of character strengths on the physiological reactivity to social anxiety induced by the Trier Social Stress Task were reported. On the basis of their scores in the Chinese Virtues Questionnaire, 30 college students were assigned to either high- (n = 15 or low-character-strength (n = 15 groups. Their psychological stress and physiological data across three laboratory stages (namely, baseline, stress exposure, and post-stress were collected. Results indicated that individuals with high character strengths exhibited rapid cardiovascular recovery from baseline to post-stress even if high- and low-character-strength groups showed similar patterns of cardiovascular arousal in response to the stress at baseline and stress exposure. These results prove that character strengths are stress-defense factors that allow for psychological and physiological adaptation to stress.

Synthesis of carbon-14 analogue of 1,5 diaryl-5-[14C]-1,2,3-triazoles

International Nuclear Information System (INIS)

Matloubi, Hojatollah; Shafiee, Abbas; Saemian, Nader; Shirvani, Gholamhossein; Daha, Fariba Johari

2004-01-01

Two 1,2,3-triazole anticonvulsants, 1-(4-methylsulfone-phenyl)-5-(4-methyl-phenyl)-1,2,3-triazole and 1-(4-methylsulfone-phenyl)-5-phenyl-1,2,3-triazole, both labeled with carbon-14 in the 5-position were prepared from para-tolunitrile-[cyano- 14 C] and benzonitrile-[cyano- 14 C], respectively

Proceedings of the International Association for Development of the Information Society (IADIS) International Conference on Mobile Learning (11th, Madeira, Portugal, March 14-16, 2015)

Science.gov (United States)

Sánchez, Inmaculada Arnedillo, Ed.; Isaías, Pedro, Ed.

2015-01-01

These proceedings contain the papers and posters of the 11th International Conference on Mobile Learning 2015, which was organised by the International Association for Development of the Information Society, in Madeira, Portugal, March 14-16, 2015. The Mobile Learning 2015 Conference seeks to provide a forum for the presentation and discussion of…

Exploitation of physiological and genetic variability to enhance crop productivity

International Nuclear Information System (INIS)

Harper, J.E.; Schrader, L.E.; Howell, R.W.

1985-01-01

The American Society of Plant Physiologists recognizes the need to identify primary physiological limitations to crop productivity. This basic information is essential to facilitate and accelerate progress towards the goal of enhanced productivity on a global scale. Plant breeders currently select for desirable physiological traits intuitively by selecting for enhanced yield capability. Identification of specific physiological limitations by plant physiologists could potentially foster interdisciplinary research and accelerate progress in breeding for improved cultivars. The recent upsurge in research interest and funding in the area of biotechnology further exemplifies the importance of identification of specific physiological traits which may be amenable to manipulation at the molecular as well as the whole plant level. The theme of this symposium was to focus attention on current progress in identification of possible physiological limitations. The purpose of this publication is to document that progress and hopefully to extend the stimulating ideas to those who were unable to attend the symposium

Molecular Breeding of Rice Restorer Lines and Hybrids for Brown Planthopper (BPH) Resistance Using the Bph14 and Bph15 Genes.

Science.gov (United States)

Wang, Hongbo; Ye, Shengtuo; Mou, Tongmin

2016-12-01

The development of hybrid rice is a practical approach for increasing rice production. However, the brown planthopper (BPH), Nilaparvata lugens Stål, causes severe yield loss of rice (Oryza sativa L.) and can threaten food security. Therefore, breeding hybrid rice resistant to BPH is the most effective and economical strategy to maintain high and stable production. Fortunately, numerous BPH resistance genes have been identified, and abundant linkage markers are available for molecular marker-assisted selection (MAS) in breeding programs. Hence, we pyramided two BPH resistance genes, Bph14 and Bph15, into a susceptive CMS restorer line Huahui938 and its derived hybrids using MAS to improve the BPH resistance of hybrid rice. Three near-isogenic lines (NILs) with pyramided Bph14 and Bph15 were obtained by molecular marker-assisted backcross (MAB) and phenotypic selection. The genomic components of these NILs were detected using the whole-genome SNP (Single nucleotide polymorphism) array, RICE6K, suggesting that the recurrent parent genome (RPG) recovery of the NILs was 87.88, 87.70 and 86.62 %, respectively. BPH bioassays showed that the improved NILs and their derived hybrids carrying homozygous Bph14 and Bph15 were resistant to BPH. However, the hybrids with heterozygous Bph14 and Bph15 remained susceptible to BPH. The developed NILs showed no significant differences in major agronomic traits and rice qualities compared with the recurrent parent. Moreover, the improved hybrids derived from the NILs exhibited better agronomic performance and rice quality compared with the controls under natural field conditions. This study demonstrates that it is essential to stack Bph14 and Bph15 into both the maternal and paternal parents for developing BPH-resistant hybrid rice varieties. The SNP array with abundant DNA markers is an efficient tool for analyzing the RPG recovery of progenies and can be used to monitor the donor segments in NILs, thus being extremely important

Performance in physiology evaluation: possible improvement by active learning strategies.

Science.gov (United States)

Montrezor, Luís H

2016-12-01

The evaluation process is complex and extremely important in the teaching/learning process. Evaluations are constantly employed in the classroom to assist students in the learning process and to help teachers improve the teaching process. The use of active methodologies encourages students to participate in the learning process, encourages interaction with their peers, and stimulates thinking about physiological mechanisms. This study examined the performance of medical students on physiology over four semesters with and without active engagement methodologies. Four activities were used: a puzzle, a board game, a debate, and a video. The results show that engaging in activities with active methodologies before a physiology cognitive monitoring test significantly improved student performance compared with not performing the activities. We integrate the use of these methodologies with classic lectures, and this integration appears to improve the teaching/learning process in the discipline of physiology and improves the integration of physiology with cardiology and neurology. In addition, students enjoy the activities and perform better on their evaluations when they use them. Copyright © 2016 The American Physiological Society.

Aging obviates sex-specific physiological responses to exercise.

Science.gov (United States)

Deschenes, Michael R; Taylor, Jessica L; Mangis, Katherine A

2013-01-01

Both sex and aging have been shown to affect physiological responses to exercise. The aim of the present investigation was to determine whether aging impacted the sex-specific nature of physiological responses to exercise commonly noted among young adults. Ten aged men (69.0 ± 1.7 years; mean ± SE) and 10 aged women (71.6 ± 1.3 years) reporting similar levels of habitual physical activity performed a 30-min exercise session at 60-65% of their predetermined peak oxygen uptake. Cardiovascular, thermoregulatory, and metabolic variables were assessed before exercise, at the 15th and 30th min of exercise, and at 5 and 15 min into a passive postexercise recovery period. Variables of interest were statistically analyzed via two-way analysis of variance with repeated measures; significance was set at P physiological variable of interest were identified, but not once was a significant effect of group (i.e., sex) detected. Exercise-induced physiological responses to prolonged, moderate intensity exercise were similar among aged men and aged women. This evidence that the sexually dimorphic nature of physiological responses to exercise is obviated with age should be taken into account when prescribing health-related exercise training programs for older individuals. Copyright © 2013 Wiley Periodicals, Inc.

Fostering improved anatomy and physiology instructor pedagogy.

Science.gov (United States)

Mattheis, Allison; Jensen, Murray

2014-12-01

Despite widespread calls for reform in undergraduate science, technology, engineering, and mathematics education, effecting lasting change in instructor practice is challenging to achieve. This article describes the results of a 2-yr research study that involved efforts to develop the pedagogical expertise of a group of anatomy and physiology instructors at the college level. Data were collected through a series of individual interviews that included the use of the Teacher Beliefs Inventory questionnaire (23) along with observations onsite in participants' college classrooms and at process-oriented guided inquiry learning (POGIL) curriculum writing workshops. Findings indicated attitudinal shifts on the part of participants from teacher-centered to more student-centered pedagogy and supported the benefits of long-term professional development for instructors. Here, we documented the successful progress of these professors as they participated in a curriculum development process that emphasized student-centered teaching with the goal of promoting broader change efforts in introductory anatomy and physiology. Copyright © 2014 The American Physiological Society.

Primary assimilation process of triply (/sup 15/N, /sup 14/C and /sup 3/H) labeled arginine in the roots of arginine-fed barley

Energy Technology Data Exchange (ETDEWEB)

Mori, Satoshi [Tokyo Univ. (Japan). Faculty of Agriculture

1981-03-01

To clarify the mechanism of arginine utilization in barley roots, triply labeled (ureido-/sup 15/N, ureido-/sup 14/C and 5-/sup 3/H) arginine was applied to plants precultured with arginine (Arg-plants). (5-/sup 3/H) Arginine was incorporated mainly into ornithine, suggesting that arginase contributes in the first step of arginine metabolism. The arginase activity in the tissues was greatly enhanced by continuous supply of arginine, whereas urease activity was not by the same treatment. The amount of /sup 14/CO/sub 2/ evolved from (ureido-/sup 14/C) arginine in the Arg-plants was several times higher than that in plants treated with NO/sub 3//sup -/(NO/sub 3/-plants), and most /sup 14/C-urea exogenously supplied to detached roots of Arg-plants was immediately decomposed to /sup 14/CO/sub 2/. The urea released from arginine by arginase was cleaved to /sup 15/NH/sub 4//sup +/ + /sup 14/CO/sub 2/ by urease. Most of the /sup 14/CO/sub 2/ was then lost from the root system. On the other hand, the released /sup 15/NH/sub 4//sup +/ was reassimilated into amino acids probably through the pathway of ammonia assimilation. Released (5-/sup 3/H) ornithine was metabolized dominantly to proline.

Longitudinal trajectories of mental health in Australian children aged 4-5 to 14-15 years.

Directory of Open Access Journals (Sweden)

Daniel Christensen

Full Text Available Mental health can affect young people's sense of wellbeing and life satisfaction, their ability to participate in employment and education, and their onward opportunities in life. This paper offers a rare opportunity to longitudinally examine mental health in a population-representative study of children aged 4-5 years to 14-15 years. Using data from the Longitudinal Study of Australian Children (LSAC, this study examined maternally-reported child mental health over a 10 year period, in order to understand their initial mental health status early in life and its change over time, as measured by the Strengths and Difficulties Questionnaire. Longitudinal models were fitted from ages 4-5 to 14-15 years. Results showed that child sex, maternal mental health, socio-economic status (family income, maternal education, neighbourhood disadvantage, maternal hostility, and child temperament (persistence, sociability, reactivity are all independent contributors to child mental health at age 4. These effects largely persist over time, with the effects of maternal mental health increasing slightly over time. Persistence of these effects suggests the need for early intervention and supports. The independent contribution of these factors to child mental health suggests that multi-faceted approaches to child and maternal mental health are needed.

First-Time Analysis of Completely Restored DTREM Instrument Data from Apollo 14 and 15

Science.gov (United States)

McBride, Marie J.; Williams, David R.; Hills, H. Kent; Turner, Niescja

2013-01-01

The Dust, Thermal and Radiation Engineering Measurement (DTREM) packages (figure 1) mounted on the central stations of the Apollo 11, 12, 14, and 15 ALSEPs (Apollo Lunar Surface Experiments Packages) measured the outputs of exposed solar cells and thermistors over time. The goal of the experiment, also commonly known as the dust detector, was to study the long-term effects of dust, radiation, and temperature at the lunar surface on solar cells. The monitors returned data for up to almost 8 years from the lunar surface.

Dehydration: physiology, assessment, and performance effects.

Science.gov (United States)

Cheuvront, Samuel N; Kenefick, Robert W

2014-01-01

This article provides a comprehensive review of dehydration assessment and presents a unique evaluation of the dehydration and performance literature. The importance of osmolality and volume are emphasized when discussing the physiology, assessment, and performance effects of dehydration. The underappreciated physiologic distinction between a loss of hypo-osmotic body water (intracellular dehydration) and an iso-osmotic loss of body water (extracellular dehydration) is presented and argued as the single most essential aspect of dehydration assessment. The importance of diagnostic and biological variation analyses to dehydration assessment methods is reviewed and their use in gauging the true potential of any dehydration assessment method highlighted. The necessity for establishing proper baselines is discussed, as is the magnitude of dehydration required to elicit reliable and detectable osmotic or volume-mediated compensatory physiologic responses. The discussion of physiologic responses further helps inform and explain our analysis of the literature suggesting a ≥ 2% dehydration threshold for impaired endurance exercise performance mediated by volume loss. In contrast, no clear threshold or plausible mechanism(s) support the marginal, but potentially important, impairment in strength, and power observed with dehydration. Similarly, the potential for dehydration to impair cognition appears small and related primarily to distraction or discomfort. The impact of dehydration on any particular sport skill or task is therefore likely dependent upon the makeup of the task itself (e.g., endurance, strength, cognitive, and motor skill). © 2014 American Physiological Society.

15 CFR 14.42 - Codes of conduct.

Science.gov (United States)

2010-01-01

... ORGANIZATIONS Post-Award Requirements Procurement Standards § 14.42 Codes of conduct. The recipient shall... standards for situations in which the financial interest is not substantial or the gift is an unsolicited...

Love-hate for man-machine metaphors in Soviet physiology: from Pavlov to "physiological cybernetics".

Science.gov (United States)

Gerovitch, Slava

2002-06-01

This article reinterprets the debate between orthodox followers of the Pavlovian reflex theory and Soviet "cybernetic physiologists" in the 1950s and 60s as a clash of opposing man-machine metaphors. While both sides accused each other of "mechanistic," reductionist methodology, they did not see anything "mechanistic" about their own central metaphors: the telephone switchboard metaphor for nervous activity (the Pavlovians), and the analogies between the human brain and a computer (the cyberneticians). I argue that the scientific utility of machine analogies was closely intertwined with their philosophical and political meanings and that new interpretations of these metaphors emerged as a result of political conflicts and a realignment of forces within the scientific community and in society at large. I suggest that the constant travel of man-machine analogies, back and forth between physiology and technology has blurred the traditional categories of the "mechanistic" and the "organic" in Soviet neurophysiology, as perhaps in the history of physiology in general.

Strongly interacting fermion systems. Progress report, November 15, 1994--November 14, 1995

International Nuclear Information System (INIS)

1994-01-01

This paper is the progress report for the period November 15, 1993 to November 14, 1994 for a program which relates to studies of strongly interacting fermion systems. The author has made significant progress in three areas, which are discussed in the report. These are: (1) optical properties in the open-quotes electronic structure program,close quotes calculating optical properties of quartz and urea; (2) quasi-one-dimensional systems, discussing the tuning of the large-density-wave or Peierls distortion in transition-metal linear chain compounds and the universal subgap optical absorptance of classes of quasi-one-dimensional compounds; and (3) other strongly interaction fermion systems, emphasizing the study of the effect of many-body interactions on the low-temperature properties of metals and superconductors

Colonic Fermentation: A Neglected Topic in Human Physiology Education

Science.gov (United States)

Valeur, Jorgen; Berstad, Arnold

2010-01-01

Human physiology textbooks tend to limit their discussion of colonic functions to those of absorbing water and electrolytes and storing waste material. However, the colon is a highly active metabolic organ, containing an exceedingly complex society of microbes. By means of fermentation, gastrointestinal microbes break down nutrients that cannot be…

A bio-inspired glucose controller based on pancreatic β-cell physiology.

Science.gov (United States)

Herrero, Pau; Georgiou, Pantelis; Oliver, Nick; Johnston, Desmond G; Toumazou, Christofer

2012-05-01

Control algorithms for closed-loop insulin delivery in type 1 diabetes have been mainly based on control engineering or artificial intelligence techniques. These, however, are not based on the physiology of the pancreas but seek to implement engineering solutions to biology. Developments in mathematical models of the β-cell physiology of the pancreas have described the glucose-induced insulin release from pancreatic β cells at a molecular level. This has facilitated development of a new class of bio-inspired glucose control algorithms that replicate the functionality of the biological pancreas. However, technologies for sensing glucose levels and delivering insulin use the subcutaneous route, which is nonphysiological and introduces some challenges. In this article, a novel glucose controller is presented as part of a bio-inspired artificial pancreas. A mathematical model of β-cell physiology was used as the core of the proposed controller. In order to deal with delays and lack of accuracy introduced by the subcutaneous route, insulin feedback and a gain scheduling strategy were employed. A United States Food and Drug Administration-accepted type 1 diabetes mellitus virtual population was used to validate the presented controller. Premeal and postmeal mean ± standard deviation blood glucose levels for the adult and adolescent populations were well within the target range set for the controller [(70, 180) mg/dl], with a percent time in range of 92.8 ± 7.3% for the adults and 83.5 ± 14% for the adolescents. This article shows for the first time very good glucose control in a virtual population with type 1 diabetes mellitus using a controller based on a subcellular β-cell model. © 2012 Diabetes Technology Society.

Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium

NARCIS (Netherlands)

V.J.M. Verhoeven (Virginie); P.G. Hysi (Pirro); S-M. Saw (Seang-Mei); V. Vitart (Veronique); A. Mirshahi (Alireza); J. Guggenheim (Jean); M.F. Cotch (Mary Frances); K. Yamashiro (Kenji); P.N. Baird (Paul); D.A. Mackey (David); R. Wojciechowski (Robert); M.K. Ikram (Kamran); A.W. Hewit (Alex); P. Duggal (Priya); S. Janmahasatian (Sarayut); C.C. Khor; Q. Fan (Qiao); X. Zhou (Xinying); T.L. Young (Terri); E.S. Tai (Shyong); L.-K. Goh; Y.J. Li (Yi); T. Aung (Tin); E.N. Vithana (Eranga); Y.Y. Teo (Yik Ying); W.-T. Tay; X. Sim (Xueling); I. Rudan (Igor); C. Hayward (Caroline); A.F. Wright (Alan); O. Polasek (Ozren); H. Campbell (Harry); J.F. Wilson (James); B. Fleck (Brian); I. Nakata (Isao); N. Yoshimura; R. Yamada (Ryo); F. Matsuda (Fumihiko); K. Ohno-Matsui (Kyoko); A. Nag (Abhishek); G. Mcmahon (George); B. St Pourcain (Beate); Y. Lu (Yi); J.S. Rahi (Jugnoo); P. Cumberland (Phillippa); S. Bhattacharya (Shoumo); C.L. Simpson (Claire); L.D. Atwood (Larry); X. Li (Xiaohui); L.J. Raffel (Leslie); D. Murgia (Daniela); L. Portas (Laura); D.D.G. Despriet (Dominique); L.M.E. van Koolwijk (Leonieke); C. Wolfram (Christian); K.J. Lackner (Karl); A. Tönjes (Anke); R. Mägi (Reedik); T. Lehtimäki (Terho); M. Kähönen (Mika); T. Esko (Tõnu); A. Metspalu (Andres); T. Rantanen (Taina); O. Pärssinen (Olavi); B.E.K. Klein (Barbara); T. Meitinger (Thomas); T.D. Spector (Timothy); B.A. Oostra (Ben); G.D. Smith; P.T.V.M. de Jong (Paulus); A. Hofman (Albert); N. Amin (Najaf); L.C. Karssen (Lennart); F. Rivadeneira Ramirez (Fernando); J.R. Vingerling (Hans); G. Eiriksdottir (Gudny); V. Gudnason (Vilmundur); A. Döring (Angela); T. Bettecken (Thomas); A.G. Uitterlinden (André); C. Williams (Cathy); T. Zeller (Tanja); R. Castagne (Raphaële); K. Oexle (Konrad); C.M. van Duijn (Cornelia); S.K. Iyengar (Sudha); P. Mitchell (Paul); J.J. Wang (Jie Jin); R. Höhn (René); A.F.H. Pfeiffer (Andreas); J.E. Bailey-Wilson (Joan); D.E. Stambolian (Dwight); T.Y. Wong (Tien Yin); C.J. Hammond (Christopher); C.C.W. Klaver (Caroline)

2012-01-01

textabstractMyopia is a complex genetic disorder and a common cause of visual impairment among working age adults. Genome-wide association studies have identified susceptibility loci on chromosomes 15q14 and 15q25 in Caucasian populations of European ancestry. Here, we present a confirmation and

Physiology in Medicine: Understanding dynamic alveolar physiology to minimize ventilator-induced lung injury.

Science.gov (United States)

Nieman, Gary F; Satalin, Josh; Kollisch-Singule, Michaela; Andrews, Penny; Aiash, Hani; Habashi, Nader M; Gatto, Louis A

2017-06-01

Acute respiratory distress syndrome (ARDS) remains a serious clinical problem with the main treatment being supportive in the form of mechanical ventilation. However, mechanical ventilation can be a double-edged sword: if set improperly, it can exacerbate the tissue damage caused by ARDS; this is known as ventilator-induced lung injury (VILI). To minimize VILI, we must understand the pathophysiologic mechanisms of tissue damage at the alveolar level. In this Physiology in Medicine paper, the dynamic physiology of alveolar inflation and deflation during mechanical ventilation will be reviewed. In addition, the pathophysiologic mechanisms of VILI will be reviewed, and this knowledge will be used to suggest an optimal mechanical breath profile (MB P : all airway pressures, volumes, flows, rates, and the duration that they are applied at both inspiration and expiration) necessary to minimize VILI. Our review suggests that the current protective ventilation strategy, known as the "open lung strategy," would be the optimal lung-protective approach. However, the viscoelastic behavior of dynamic alveolar inflation and deflation has not yet been incorporated into protective mechanical ventilation strategies. Using our knowledge of dynamic alveolar mechanics (i.e., the dynamic change in alveolar and alveolar duct size and shape during tidal ventilation) to modify the MB P so as to minimize VILI will reduce the morbidity and mortality associated with ARDS. Copyright © 2017 the American Physiological Society.

15N/14N isotopic ratio and statistical analysis: an efficient way of linking seized Ecstasy tablets

International Nuclear Information System (INIS)

Palhol, Fabien; Lamoureux, Catherine; Chabrillat, Martine; Naulet, Norbert

2004-01-01

In this study, the 15 N/ 14 N isotopic ratios of 106 samples of 3,4-methylenedioxymethamphetamine (MDMA) extracted from Ecstasy tablets are presented. These ratios, measured using gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS), show a large discrimination between samples with a range of δ 15 N values between -17 and +19%o, depending on the precursors and the method used in clandestine laboratories. Thus, δ 15 N values can be used in a statistical analysis carried out in order to link Ecstasy tablets prepared with the same precursors and synthetic pathway. The similarity index obtained after principal component analysis and hierarchical cluster analysis appears to be an efficient way to group tablets seized in different places

Intra-articular sodium hyaluronate 2 mL versus physiological saline 20 mL versus physiological saline 2 mL for painful knee osteoarthritis: a randomized clinical trial

DEFF Research Database (Denmark)

Lundsgaard, C.; Dufour, N.; Fallentin, E.

2008-01-01

, Knee Injury and Osteoarthritis Outcome Score (KOOS), Osteoarthritis Research Society International (OARSI) criteria, and global assessment of the patient's condition. Results: The mean age of the patients was 69.4 years; 55% were women. The effects of hyaluronate 2 mL, physiological saline 20 m......Objective: Methodological constraints weaken previous evidence on intra-articular viscosupplementation and physiological saline distention for osteoarthritis. We conducted a randomized, patient- and observer-blind trial to evaluate these interventions in patients with painful knee osteoarthritis....... Methods: We centrally randomized 251 patients with knee ostcoarthritis to four weekly intra-articular injections of sodium hyaluronate 2 mL (Hyalgan(R) 10.3 mg/mL) versus physiological saline 20 mL (distention) versus physiological saline 2 mL (placebo) and followed patients for 26 weeks. Inclusion...

ANTI-ALLERGIC EFFECTS OF 1,5-BIS(4’-HYDROXY-3’-METHOXYPHENYL-1,4-PENTADIENE-3-ONE ON MAST CELL-MEDIATED ALLERGY MODEL

Directory of Open Access Journals (Sweden)

AGUNG ENDRO NUGROHO

2009-01-01

Full Text Available 1,5-bis(4’-hydroxy-3’-methoxyphenyl-1,4-pentadiene-3-one is a 1,5-diphenyl-1,4-pentadiene-3-one analogue of curcumin that is produced by modifying the middle site of curcumin leading to 1,4-pentadiene-3-ones to maintain the hydroxy moiety at the aromatic rings that are responsible for its biological activities. Curcumin has been reported to have anti-allergic effects and can inhibit the release of histamine from mast cells. In the present study, we evaluated the anti-allergic effects of 1,5-bis(4’-hydroxy-3’-methoxyphenyl-1,4-pentadiene-3-one in a mast cell-mediated allergy mode in order to provide information about a newly synthesised-compound for an alternative allergy drug. The study was performed using (1 a rat basophilic leukaemia (RBL-2H3 cell line, which is a tumour analogue of mast cells, with DNP24-BSA, thapsigargin and ionomycin as inducers for secretory markers from mast cells, and (2 an active cutaneous anaphylaxis (ACA reaction, with ovalbumin as an inductor of mast cell degranulation. Treatment with 1,5-bis(4’-hydroxy-3’-methoxyphenyl-1,4-pentadiene-3-one strongly inhibited the DNP24-BSA, thapsigargin and ionomycin-mediated release of histamine and β-hexosaminidase from the RBL-2H3 cell line. The results indicated that this compound influenced the activation processes of FcεRI by antigen and intracellular Ca2+ signalling events in mast cells. In type 1 allergy model, this compound also inhibited the active cutaneous anaphylactic reaction on rat dorsal skins generated by ovalbumin. We conclude that the compound 1,5-bis(4’-hydroxy-3’-methoxyphenyl-1,4-pentadiene-3-one showed anti-allergic activities mediated by mechanisms related to intracellular signalling events in mast cells.

Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium

NARCIS (Netherlands)

Verhoeven, Virginie J. M.; Hysi, Pirro G.; Saw, Seang-Mei; Vitart, Veronique; Mirshahi, Alireza; Guggenheim, Jeremy A.; Cotch, Mary Frances; Yamashiro, Kenji; Baird, Paul N.; Mackey, David A.; Wojciechowski, Robert; Ikram, M. Kamran; Hewitt, Alex W.; Duggal, Priya; Janmahasatian, Sarayut; Khor, Chiea-Chuen; Fan, Qiao; Zhou, Xin; Young, Terri L.; Tai, E.-Shyong; Goh, Liang-Kee; Li, Yi-Ju; Aung, Tin; Vithana, Eranga; teo, Yik-Ying; Tay, Wanting; Sim, Xueling; Rudan, Igor; Hayward, Caroline; Wright, Alan F.; Polasek, Ozren; Campbell, Harry; Wilson, James F.; Fleck, Brian W.; Nakata, Isao; Yoshimura, Nagahisa; Yamada, Ryo; Matsuda, Fumihiko; Ohno-Matsui, Kyoko; Nag, Abhishek; McMahon, George; St Pourcain, Beate; Lu, Yi; Rahi, Jugnoo S.; Cumberland, Phillippa M.; Bhattacharya, Shomi; Simpson, Claire L.; Atwood, Larry D.; Li, Xiaohui; Raffel, Leslie J.; Murgia, Federico; Portas, Laura; Despriet, Dominiek D. G.; van Koolwijk, Leonieke M. E.; Wolfram, Christian; Lackner, Karl J.; Tönjes, Anke; Mägi, Reedik; Lehtimäki, Terho; Kähönen, Mika; Esko, Tõnu; Metspalu, Andres; Rantanen, Taina; Pärssinen, Olavi; Klein, Barbara E.; Meitinger, Thomas; Spector, Timothy D.; Oostra, Ben A.; Smith, Albert V.; de Jong, Paulus T. V. M.; Hofman, Albert; Amin, Najaf; Karssen, Lennart C.; Rivadeneira, Fernando; Vingerling, Johannes R.; Eiríksdóttir, Guðný; Gudnason, Vilmundur; Döring, Angela; Bettecken, Thomas; Uitterlinden, André G.; Williams, Cathy; Zeller, Tanja; Castagné, Raphaële; Oexle, Konrad; van Duijn, Cornelia M.; Iyengar, Sudha K.; Mitchell, Paul; Wang, Jie Jin; Höhn, René; Pfeiffer, Norbert; Bailey-Wilson, Joan E.; Stambolian, Dwight; Wong, Tien-Yin; Hammond, Christopher J.; Klaver, Caroline C. W.

2012-01-01

Myopia is a complex genetic disorder and a common cause of visual impairment among working age adults. Genome-wide association studies have identified susceptibility loci on chromosomes 15q14 and 15q25 in Caucasian populations of European ancestry. Here, we present a confirmation and meta-analysis

Comparative gut physiology symposium: The microbe-gut-brain axis

Science.gov (United States)

The Comparative Gut Physiology Symposium titled “The Microbe-Gut-Brain Axis” was held at the Joint Annual Meeting of the American Society of Animal Science and the American Dairy Science Association on Thursday, July 21, 2016, in Salt Lake City Utah. The goal of the symposium was to present basic r...

The evolution of the Society for the Study of Ingestive Behavior (SSIB).

Science.gov (United States)

Kissileff, Harry R; Ladenheim, Ellen

2013-09-10

This review summarizes the formation of the Society for the Study of Ingestive Behavior (SSIB), highlighting the many people whose commitment and perseverance brought together a wide range of disciplines for the common goal of investigating ingestive behavior and providing communication via scientific meetings. The goals and philosophy of the Society today are described along with the challenges it will face in the future. It concludes with the important message that excellence in science, combined with commitment to, and participation from, younger investigators, will ensure its continued success. The SSIB was officially incorporated on March 30, 1987 to serve a unique niche within the biological and behavioral sciences. Its initial vision was to serve as the "leading scientific organization for the study of ingestive behavior". This mission continues to drive the philosophy of the Society which currently boasts over 350 members representing 30 different countries. The SSIB melded scientific disciplines that included physiological and psychological aspects of food and fluid intake, as well as taste and olfaction. Prior to its creation, scientists from each of these disciplines met at several key conferences, most notably The International Conference on the Physiology of Food and Fluid Intake, a now defunct satellite of the International Union of Physiological Sciences, and The Eastern Psychological Association. From these and other smaller conferences came the idea of forming a society that integrated research from the biological, psychological and social aspects of food and fluid intake in both animals and humans. While this emphasis of the Society remains today, changing scientific priorities and interests continue to shape and influence the direction of the Society. Since its first meeting held at Princeton University in NJ in 1992, the annual meeting has become a major means of disseminating cutting-edge information on current research in the field of

Bicarbonate as tracer for plant assimilated C and homogeneity of 14C and 15N distribution in ryegrass and white clover tissue by alternative labeling approaches

DEFF Research Database (Denmark)

Rasmussen, Jim; Kusliene, Gedrime; Jacobsen, Ole Stig

2013-01-01

that 15N also had a heterogeneous distribution (up to two orders of magnitude). Conclusion Bicarbonate can efficiently be used to introduce 14C or 13C into plant via the leaf-labeling method. Both 14C and 15N showed heterogeneous distribution in the plant, although the distribution of 15N was more even......Aims: Application of carbon (C) and nitrogen (N) isotopes is an essential tool to study C and N flows in plant-soil-microorganisms systems. When targeting single plants in a community the tracers need to be added via e.g., leaf-labeling or stem-feeding approaches. In this study we: (i) investigated...... if bicarbonate can be used to introduce 14C (or 13C) into white clover and ryegrass, and (ii) compared the patterns of 14C and 15N allocation in white clover and ryegrass to evaluate the homogeneity of tracer distribution after two alternative labeling approaches. Methods Perennial ryegrass and white clover were...

Back to the future! Revisiting the physiological cost of negative work as a team-based activity for exercise physiology students.

Science.gov (United States)

Kilgas, Matthew A; Elmer, Steven J

2017-03-01

We implemented a team-based activity in our exercise physiology teaching laboratory that was inspired from Abbott et al.'s classic 1952 Journal of Physiology paper titled "The physiological cost of negative work." Abbott et al. connected two bicycles via one chain. One person cycled forward (muscle shortening contractions, positive work) while the other resisted the reverse moving pedals (muscle lengthening contractions, negative work), and the cost of work was compared. This study was the first to link human whole body energetics with isolated muscle force-velocity characteristics. The laboratory activity for our students ( n = 35) was designed to reenact Abbott et al.'s experiment, integrate previously learned techniques, and illustrate differences in physiological responses to muscle shortening and lengthening contractions. Students (11-12 students/laboratory section) were split into two teams (positive work vs. negative work). One student from each team volunteered to cycle against the other for ~10 min. The remaining students in each team were tasked with measuring: 1 ) O 2 consumption, 2 ) heart rate, 3 ) blood lactate, and 4 ) perceived exertion. Students discovered that O 2 consumption during negative work was about one-half that of positive work and all other physiological parameters were also substantially lower. Muscle lengthening contractions were discussed and applied to rehabilitation and sport training. The majority of students (>90%) agreed or strongly agreed that they stayed engaged during the activity and it improved their understanding of exercise physiology. All students recommended the activity be performed again. This activity was engaging, emphasized teamwork, yielded clear results, was well received, and preserved the history of classic physiological experiments. Copyright © 2017 the American Physiological Society.

Anatomy and Physiology. Revised Teacher Edition.

Science.gov (United States)

Hartman, Danene; And Others

This curriculum guide contains 14 units of instruction for a course in anatomy and physiology for surgical technology students. The units cover the following topics: (1) organization of the body; (2) cells, tissues, and membranes; (3) integumentary system; (4) skeletal system; (5) muscular system; (6) nervous system; (7) special sense organs; (8)…

15th Conference of the International Federation of Classification Societies

CERN Document Server

Montanari, Angela; Vichi, Maurizio

2017-01-01

This edited volume on the latest advances in data science covers a wide range of topics in the context of data analysis and classification. In particular, it includes contributions on classification methods for high-dimensional data, clustering methods, multivariate statistical methods, and various applications. The book gathers a selection of peer-reviewed contributions presented at the Fifteenth Conference of the International Federation of Classification Societies (IFCS2015), which was hosted by the Alma Mater Studiorum, University of Bologna, from July 5 to 8, 2015.

Physiological conditions and uptake of inorganic carbon-14 by plant roots

International Nuclear Information System (INIS)

Amiro, B.D.; Ewing, L.L.

1992-01-01

The uptake of inorganic 14 C by bean plant roots was measured. The plants were grown in a nutrient solution culture at pH 6 and a NaH 14 CO 3 tracer was added to the growth medium. Photosynthesis and transpiration were varied by exposing the aerial portions of the plants to different atmospheric CO 2 concentrations, humidities and light levels in a cuvette system. Leaf concentrations of 14 C were measured at the end of the experiments using liquid scintillation counting. Plant uptake of 14 C via the roots was independent of the photosynthetic rate and, in most cases, could be predicted by knowing the transpiration rate and the nutrient solution concentration. However, when a less efficient root-medium aeration system was used, 14 C uptake was greater than that predicted using transpiration, a phenomenon observed by other researchers. This contrasted to results of another experiment where the measured uptake of iodine was much slower than that predicted using transpiration. Knowledge of transpiration rates is useful in predicting inorganic carbon uptake via the roots and in estimating 14 C transport from contaminated soils to biota. Also, the independence of the uptake from photosynthesis and ambient CO 2 concentrations suggests that future increases in atmospheric CO 2 concentrations may not have a direct effect on root uptake of soil carbon. (author)

15 CFR 14.26 - Non-Federal audits.

Science.gov (United States)

2010-01-01

... FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, OTHER NON-PROFIT, AND COMMERCIAL ORGANIZATIONS Post-Award Requirements Financial and Program Management § 14.26 Non-Federal audits. (a) Recipients and subrecipients that are institutions of higher education or other non-profit...

Importance of amylases for physiological quality in maize seeds

Directory of Open Access Journals (Sweden)

Camila Aparecida Lopes

2017-09-01

Full Text Available Seed quality is the result of the sum of genetic, physical, physiological and sanitary attributes that affect seed ability to perform vital functions related to germination, vigor, and longevity. The expression of genes associated with physiological quality can be assessed by means of germination and vigor analyses, as well as by transcript and protein analyses. The objective in this work was to review the relevance of amylase group enzymes to the physiological quality of maize seeds. Within this group, α-amylase (1,4-α-D-glucan glucanohydrolase E.C 3.2.1.1 plays an important role in starch hydrolysis, and is responsible for 90% of the amylolytic activity in maize seeds. It is responsible for starch conversion into sugars (e.g., destrin, which is used for embryo growth. β-amylase (1,4-α-D-glucan maltohydrolase E.C 3.2.1.2 catalyzes the release of maltose and dextrins from the non-reducing ends of starch. Research has shown that amylase enzymes are directly linked to physiological quality of maize seeds. Alpha- and beta-amylases are mainly involved in the germination process and seed heterosis, and can also be used as molecular markers associated with seed tolerance for drying.

Bullying at work, health outcomes, and physiological stress response

DEFF Research Database (Denmark)

Hansen, Ase Marie; Hogh, Annie; Persson, Roger

2006-01-01

The relationships among bullying or witnessing bullying at work, self-reported health symptoms, and physiological stress reactivity were analysed in a sample of 437 employees (294 women and 143 men). Physiological stress reactivity was measured as cortisol in the saliva. Of the respondents, 5......% of the women (n=15) and 5% of the men (n=7) reported bullying, whereas 9% of the women (n=25) and 11% of the men (n=15) had witnessed bullying at work. The results indicated that the bullied respondents had lower social support from coworkers and supervisors, and they reported more symptoms of somatisation...... with nonbullied respondents. Previous studies have reported lower diurnal concentration of cortisol for people with posttraumatic stress disorder (PTSD) and chronic fatigue. To our knowledge, this is the first full study on the associations among being subjected to bullying, health outcomes, and physiological...

APS: 125 Years of Progress of Physiology as a Scientific Discipline and a Profession

Science.gov (United States)

Carroll, Robert G.; Frank, Martin; Ra'anan, Alice; Matyas, Marsha L.

2013-01-01

The Experimental Biology 2012 meeting in San Diego, CA, included events to celebrate the 125th anniversary of the founding of the American Physiological Society (APS) and reflect on the recent accomplishments of the society. Most of the APS activities in the past quarter century were guided by a series of strategic plans. Membership in the APS…

The Physiology Undergraduate Major in the University of Arizona College of Medicine: Past, Present, and Future

Science.gov (United States)

Henriksen, Erik J.; Atwater, Anne E.; Delamere, Nicholas A.; Dantzler, William H.

2011-01-01

The American Physiological Society (APS) and APS Council encourage the teaching of physiology at the undergraduate, graduate, and medical school levels to support the continued prominence of this area of science. One area identified by the APS Council that is of particular importance for the development of future physiologists (the…

Physiological Indices of Pilots' Abilities Under Varying Task Demands.

Science.gov (United States)

Wang, Zhen; Zheng, Lingxiao; Lu, Yanyu; Fu, Shan

2016-04-01

This study investigated pilots' ability by examining the effects of flight experience and task demand on physiological reactions, and analyzing the diagnostic meanings underlying correlated parameters. A total of 12 experienced pilots and 12 less experienced pilots performed 4 simulated flight tasks, including normal and emergency situations. Fixation duration (FD), saccade rate (SR), blink rate (BR), heart rate (HR), respiration rate (RR), and respiration amplitude (RA) were measured during the tasks. More experienced pilots adapted their SR flexibly to changing task demands and had significantly lower SR than less experienced pilots during emergency tasks (29.6 ± 20.0 vs. 70.1 ± 67.1 saccades/min). BR, HR, and RR were affected by pilot experience but not by task demand. More experienced pilots had lower BR, HR, and RR than less experienced pilots during both normal tasks (BR: 14.3 ± 13.0 vs. 32.9 ± 25.8 blinks/min; HR: 72.7 ± 7.9 vs. 83.2 ± 7.2 bpm; RR: 15.4 ± 2.1 vs. 19.5 ± 5.2 breaths/min) and emergency tasks (BR: 10.2 ± 5.0 vs. 32.3 ± 20.8 blinks/min; HR: 73.3 ± 7.3 vs. 82.2 ± 11.6 bpm; RR: 15.6 ± 1.9 vs. 18.0 ± 3.2 breaths/min). FD and RA were not sensitive to either flight experience or task demand. Physiological reactions have the potential to reflect pilots' ability from different aspects. SR and BR could indicate pilots' differences in information access strategy. HR and RR could reflect a pilot's physical fitness. These findings are useful for understanding a pilot's ability.

Multimodal integration of anatomy and physiology classes: How instructors utilize multimodal teaching in their classrooms

Science.gov (United States)

McGraw, Gerald M., Jr.

Multimodality is the theory of communication as it applies to social and educational semiotics (making meaning through the use of multiple signs and symbols). The term multimodality describes a communication methodology that includes multiple textual, aural, and visual applications (modes) that are woven together to create what is referred to as an artifact. Multimodal teaching methodology attempts to create a deeper meaning to course content by activating the higher cognitive areas of the student's brain, creating a more sustained retention of the information (Murray, 2009). The introduction of multimodality educational methodologies as a means to more optimally engage students has been documented within educational literature. However, studies analyzing the distribution and penetration into basic sciences, more specifically anatomy and physiology, have not been forthcoming. This study used a quantitative survey design to determine the degree to which instructors integrated multimodality teaching practices into their course curricula. The instrument used for the study was designed by the researcher based on evidence found in the literature and sent to members of three associations/societies for anatomy and physiology instructors: the Human Anatomy and Physiology Society; the iTeach Anatomy & Physiology Collaborate; and the American Physiology Society. Respondents totaled 182 instructor members of two- and four-year, private and public higher learning colleges collected from the three organizations collectively with over 13,500 members in over 925 higher learning institutions nationwide. The study concluded that the expansion of multimodal methodologies into anatomy and physiology classrooms is at the beginning of the process and that there is ample opportunity for expansion. Instructors continue to use lecture as their primary means of interaction with students. Email is still the major form of out-of-class communication for full-time instructors. Instructors with

Carbon 14

International Nuclear Information System (INIS)

2002-03-01

Carbon 14 is one of the most abundant radionuclides of natural and artificial origin in the environment. The aim of this conference day organized by the French society of radioprotection (SFRP) was to take stock of our knowledge about this radionuclide (origins, production, measurement, management, effects on health..): state-of-the-art of 14 C metrology; dating use of 14 C; 14 C management and monitoring of the Hague site environment; Electricite de France (EdF) and 14 C; radiological and sanitary impact of 14 C contamination at the Ganagobie site (Haute-Provence, France); metabolism and biological effects of 14 C; 14 C behaviour in the marine environment near Cogema-La Hague plant; distribution of 14 C activities in waters, mud and sediments of the Loire river estuary; dynamical modeling of transfers in the aquatic and terrestrial environment of 14 C released by nuclear power plants in normal operation: human dose calculation using the Calvados model and application to the Loire river; 14 C distribution in continents; modeling of 14 C transfers in the terrestrial environment from atmospheric sources. (J.S.)

Synthesis of carbon-14 analogue of 1,5 diaryl-5-[{sup 14}C]-1,2,3-triazoles

Energy Technology Data Exchange (ETDEWEB)

Matloubi, Hojatollah E-mail: hmatloubi@aeoi.org.ir; Shafiee, Abbas; Saemian, Nader; Shirvani, Gholamhossein; Daha, Fariba Johari

2004-05-01

Two 1,2,3-triazole anticonvulsants, 1-(4-methylsulfone-phenyl)-5-(4-methyl-phenyl)-1,2,3-triazole and 1-(4-methylsulfone-phenyl)-5-phenyl-1,2,3-triazole, both labeled with carbon-14 in the 5-position were prepared from para-tolunitrile-[cyano-{sup 14}C] and benzonitrile-[cyano-{sup 14}C], respectively.

Zinc: physiology, deficiency, and parenteral nutrition.

Science.gov (United States)

Livingstone, Callum

2015-06-01

The essential trace element zinc (Zn) has a large number of physiologic roles, in particular being required for growth and functioning of the immune system. Adaptive mechanisms enable the body to maintain normal total body Zn status over a wide range of intakes, but deficiency can occur because of reduced absorption or increased gastrointestinal losses. Deficiency impairs physiologic processes, leading to clinical consequences that include failure to thrive, skin rash, and impaired wound healing. Mild deficiency that is not clinically overt may still cause nonspecific consequences, such as susceptibility to infection and poor growth. The plasma Zn concentration has poor sensitivity and specificity as a test of deficiency. Consequently, diagnosis of deficiency requires a combination of clinical assessment and biochemical tests. Patients receiving parenteral nutrition (PN) are susceptible to Zn deficiency and its consequences. Nutrition support teams should have a strategy for assessing Zn status and optimizing this by appropriate supplementation. Nutrition guidelines recommend generous Zn provision from the start of PN. This review covers the physiology of Zn, the consequences of its deficiency, and the assessment of its status, before discussing its role in PN. © 2015 American Society for Parenteral and Enteral Nutrition.

Investigation on the absorption of 14C-leucine and 15N-leucine in rats after feeding a fish meal diet in comparison with a gelatine diet

International Nuclear Information System (INIS)

Bergner, U.; Adam, K.; Bergner, H.

1981-01-01

Albino rats received after nine days of adaptation to a fish meal diet in comparison with a gelatine diet 14 C-U-L-leucine and 15 N-L-leucine via a pellet made from the specific diet after food deprivation for 15 h. Thereafter, the animals consumed the non-labelled experimental diet ad libitum. 30 min, and 1, 2, 4 and 8 h, resp., after intake of the labelled food, four rats at a time were sacrificed. The contents of the digestive tract and tissue samples were examined for 14 C and 15 N and their percentages in the TCA-soluble fraction determined. If these values are regarded as non-absorbed leucine, the 14 C values obtained up to the four hour period of the experiment would be too high. Presumably, they are in the case of both diets simulated by other 14 C metabolites which originate from the leucine catabolism and reach the intestinal lumen. Amino acids labelled with 15 N should be preferred in studies on the absorption of amino acids because, in case of catabolization, the 15 N aminogroup is excreted mainly as urea via urine. (author)

T15

Directory of Open Access Journals (Sweden)

E. Kaigorodova

2015-11-01

The study was conducted with financial support from the Council for Grants of the President of the Russian Federation (Russia for the state support of young philosophy doctors, agreements of SC 114.120.14.168-MD Russian Scientific Foundation (Russia, Grant No. 14-15-00318 (sample collection and Russian Foundation for Basic Research (Russia, Grant No. 15-34-20864. We acknowledge support of this work by the Tomsk State University Competitiveness Improvement Program (Russia.

Changing undergraduate human anatomy and physiology laboratories: perspectives from a large-enrollment course.

Science.gov (United States)

Griff, Edwin R

2016-09-01

In the present article, a veteran lecturer of human anatomy and physiology taught several sections of the laboratory component for the first time and shares his observations and analysis from this unique perspective. The article discusses a large-enrollment, content-heavy anatomy and physiology course in relationship to published studies on learning and student self-efficacy. Changes in the laboratory component that could increase student learning are proposed. The author also points out the need for research to assess whether selective curricular changes could increase the depth of understanding and retention of learned material. Copyright © 2016 The American Physiological Society.

Measurements of nitrogen depth distribution in the surface of steel with the 14N(d,p0)15N reaction

International Nuclear Information System (INIS)

Didriksson, R.; Goenczi, L.; Sundqvist, B.

1980-01-01

The 14 N(d,p 0 ) 15 N nuclear reaction has been used to measure the nitrogen depth distribution in the surface of steel samples. With a beam energy of 2.5 MeV a depth of 15μm could be analyzed. The depth resolution was 0.7 μm (FWHM) and nitrogen contents down to 0.02 percent could be determined. (author)

(Helianthus annuus L.) on physiology of wheat

African Journals Online (AJOL)

STORAGESEVER

2009-08-04

Aug 4, 2009 ... African Journal of Biotechnology Vol. 8 (15), pp. 3555-3559, 4 ... physiology of wheat seedlings including protein, proline, sugars, DNA, peroxidase, superoxide dismutase and .... (1956) as modified by Johnson et al. (1966).

Study of the reaction 14 C (p,p) 14 C

International Nuclear Information System (INIS)

Murillo, G.; Ramirez, J.; Avila, O.; Fernandez, M.; Darden, S.E.; Prior, R.P.; Sen, S.

1991-04-01

The study of the elastic scattering of polarized protons in 14 C, it has been very limited. Some angular distributions exists to low energy, as well as measures of excitation functions to several angles for the differential section and the vectorial analyzer power. A detailed study of the elastic scattering of protons by 14 C, it give us experimental information of the excited states in 15 N. The study of these states, is since of considerable interest it is not very easy to obtain a target of 14 C also in a reaction 14 C (p,p) 14 C is possible to obtain information of levels in 15 N to an excitation energy E X >14.95 MeV. (Author)

Core drilling of drillholes ONK-KR13, ONK-KR14 and ONK-KR15 in ONKALO at Olkiluoto 2010 - 2011

International Nuclear Information System (INIS)

Toropainen, V.

2011-08-01

As a part of the confirming site investigations at Olkiluoto, Suomen Malmi Oy (Smoy) core drilled three drillholes ONK-KR13 (120.45 m), ONK-KR14 (75.27 m) and ONK-KR15 (79.96 m) in ONKALO, at Olkiluoto in June 2010 - March 2011. The diameter of the drillholes is 75.7 mm. Sodium fluorescein was used as a label agent in the drilling water, and the drillholes were washed and flushed after the drilling. The deviations of the drillholes were measured with the deviation measuring instruments EMS and Gyro. The core samples were logged according to Posiva's normal procedure for drillholes. The main rock types are veined and diatexitic gneisses and pegmatitic granite. The average natural fracture frequencies and RQDs of the core samples are 1.6 pcs/m and 97.0 % (ONK-KR13), 0.5 pcs/m and 99.3 % (ONK-KR14) and 1.6 pcs/m and 97.3 % (ONK-KR15). In drillhole ONK-KR13 one, and in drillhole ONK-KR15 three fractured zones were intersected. There was no fractured zones in drillhole ONK-KR14. Rock mechanical tests were performed to core samples. The average uniaxial compressive strength was 143.2 MPa, the average Young's Modulus was 57.3 GPa and the average Poisson's ratio was 0.25. (orig.)

Atomic resolution studies of haloalkane dehalogenases DhaA04, DhaA14 and DhaA15 with engineered access tunnels.

Science.gov (United States)

Stsiapanava, A; Dohnalek, J; Gavira, J A; Kuty, M; Koudelakova, T; Damborsky, J; Kuta Smatanova, I

2010-09-01

The haloalkane dehalogenase DhaA from Rhodococcus rhodochrous NCIMB 13064 is a bacterial enzyme that shows catalytic activity for the hydrolytic degradation of the highly toxic industrial pollutant 1,2,3-trichloropropane (TCP). Mutagenesis focused on the access tunnels of DhaA produced protein variants with significantly improved activity towards TCP. Three mutants of DhaA named DhaA04 (C176Y), DhaA14 (I135F) and DhaA15 (C176Y + I135F) were constructed in order to study the functional relevance of the tunnels connecting the buried active site of the protein with the surrounding solvent. All three protein variants were crystallized using the sitting-drop vapour-diffusion technique. The crystals of DhaA04 belonged to the orthorhombic space group P2(1)2(1)2(1), while the crystals of DhaA14 and DhaA15 had triclinic symmetry in space group P1. The crystal structures of DhaA04, DhaA14 and DhaA15 with ligands present in the active site were solved and refined using diffraction data to 1.23, 0.95 and 1.22 A, resolution, respectively. Structural comparisons of the wild type and the three mutants suggest that the tunnels play a key role in the processes of ligand exchange between the buried active site and the surrounding solvent.

A study of the reactions 14C( vector d, dprime)14C and 14C ( vector d, p)15C at 16.0 MeV

International Nuclear Information System (INIS)

Murillo, G.; Sen, S.; Darden, S.E.

1994-01-01

Cross-section and vector-analyzing-power measurements for 14 C(d, d prime) and 14 C(d, p) reactions have been carried out for E d =16 MeV. The inelastic-scattering data have been analyzed using the DWBA with a collective and a microscopic model form-factor and also by using the coupled-channels formalism with a vibrational model form-factor. It is observed that while the cross-section angular-distribution data for the two 2 + states at E x =7.012 and 8.318 MeV are very similar, the corresponding vector analyzing powers are quite different. The results of the analyses indicate that the distinctive characteristics probably arise from the difference in the relative importance of the proton and neutron components in the transition amplitude. The 3 - state at E x =6.728 MeV is identified as predominantly a 1p-3h state. Although the deformation parameters are relatively large, the single-particle structure aspects play a more dominant role than channel-coupling effects in populating the inelastic states. The transfer reaction data have been analyzed using the DWBA for bound and unbound states. The importance of two-step processes has been investigated via coupled-reaction-channels calculations. The g.s. and the states with excitation energies 0.770, 3.103 and 4.78 MeV in 15 C are populated primarily by a one-step process with a small two-step contribution in the case of the 3.103 MeV state. The 4.22 MeV state is populated predominantly by two-step processes. The 4.78 and the 5.83 MeV states have been identified as 1p-2h and 3p-4h, [3]/[2] + state, respectively, in an earlier report. There is close similarity in the level structures and reaction mechanisms between the states of 15 C and 17 O populated via the (d, p) reaction. ((orig.))

Physiology, production and action of progesterone.

Science.gov (United States)

Taraborrelli, Stefania

2015-11-01

The aim of this article is to review the physiology of progesterone and focus on its physiological actions on tissues such as endometrium, uterus, mammary gland, cardiovascular system, central nervous system and bones. In the last decades, the interest of researchers has focused on the role of progesterone in genomic and non-genomic receptor mechanisms. We searched PubMed up to December 2014 for publications on progesterone/steroidogenesis. A better understanding of the biological genomic and non-genomic receptor mechanisms could enable us in the near future to obtain a more comprehensive knowledge of the safety and efficacy of this agent during hormone replacement therapy (natural progesterone), in vitro fertilization (water-soluble subcutaneous progesterone), in traumatic brain injury, Alzheimer's disease and diabetic neuropathy, even though further clinical studies are needed to prove its usefulness. © 2015 Nordic Federation of Societies of Obstetrics and Gynecology.

33 CFR 89.25 - Waters upon which Inland Rules 9(a)(ii), 14(d), and 15(b) apply.

Science.gov (United States)

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Waters upon which Inland Rules 9(a)(ii), 14(d), and 15(b) apply. 89.25 Section 89.25 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INLAND NAVIGATION RULES INLAND NAVIGATION RULES: IMPLEMENTING RULES Waters...

Solid-Liquid Equilibria for the Binary Mixtures 1,4-Xylene + Ethylbenzene and 1,4-Xylene + Toluene

DEFF Research Database (Denmark)

Huyghe, Raphaël; Rasmussen, Peter; Thomsen, Kaj

2004-01-01

Solid-liquid equilibrium (SLE) data for the binary mixtures 1,4-xylene + ethylbenzene, and 1,4-xylene + toluene have been measured using differential scanning calorimetry (DSC) in the temperature range from 133.15 K to 293.15 K.......Solid-liquid equilibrium (SLE) data for the binary mixtures 1,4-xylene + ethylbenzene, and 1,4-xylene + toluene have been measured using differential scanning calorimetry (DSC) in the temperature range from 133.15 K to 293.15 K....

Linking Insects with Crustacea: Physiology of the Pancrustacea: An Introduction to the Symposium.

Science.gov (United States)

Tamone, Sherry L; Harrison, Jon F

2015-11-01

Insects and crustaceans represent critical, dominant animal groups (by biomass and species number) in terrestrial and aquatic systems, respectively. Insects (hexapods) and crustaceans are historically grouped under separate taxonomic classes within the Phylum Arthropoda, and the research communities studying hexapods and crustaceans are quite distinct. More recently, the hexapods have been shown to be evolutionarily derived from basal crustaceans, and the clade Pancrustacea recognizes this relationship. This recent evolutionary perspective, and the fact that the Society for Integrative and Comparative Biology has strong communities in both invertebrate biology and insect physiology, provides the motivation for this symposium. Speakers in this symposium were selected because of their expertise in a particular field of insect or crustacean physiology, and paired in such a way as to provide a comparative view of the state of the current research in their respective fields. Presenters discussed what aspects of the physiological system are clearly conserved across insects and crustaceans and how cross-talk between researchers utilizing insects and crustaceans can fertilize understanding of such conserved systems. Speakers were also asked to identify strategies that would enable improved understanding of the evolution of physiological systems of the terrestrial insects from the aquatic crustaceans. The following collection of articles describes multiple recent advances in our understanding of Pancrustacean physiology. © The Author 2015. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

Martin Gibbs (1922-2006): Pioneer of (14)C research, sugar metabolism & photosynthesis; vigilant Editor-in-Chief of Plant Physiology; sage Educator; and humanistic Mentor.

Science.gov (United States)

Black, Clanton C

2008-01-01

The very personal touch of Professor Martin Gibbs as a worldwide advocate for photosynthesis and plant physiology was lost with his death in July 2006. Widely known for his engaging humorous personality and his humanitarian lifestyle, Martin Gibbs excelled as a strong international science diplomat; like a personal science family patriarch encouraging science and plant scientists around the world. Immediately after World War II he was a pioneer at the Brookhaven National Laboratory in the use of (14)C to elucidate carbon flow in metabolism and particularly carbon pathways in photosynthesis. His leadership on carbon metabolism and photosynthesis extended for four decades of working in collaboration with a host of students and colleagues. In 1962, he was selected as the Editor-in-Chief of Plant Physiology. That appointment initiated 3 decades of strong directional influences by Gibbs on plant research and photosynthesis. Plant Physiology became and remains a premier source of new knowledge about the vital and primary roles of plants in earth's environmental history and the energetics of our green-blue planet. His leadership and charismatic humanitarian character became the quintessence of excellence worldwide. Martin Gibbs was in every sense the personification of a model mentor not only for scientists but also shown in devotion to family. Here we pay tribute and honor to an exemplary humanistic mentor, Martin Gibbs.

The vaginal microbiota, host defence and reproductive physiology.

Science.gov (United States)

Smith, Steven B; Ravel, Jacques

2017-01-15

The interaction between the human host and the vaginal microbiota is highly dynamic. Major changes in the vaginal physiology and microbiota over a woman's lifetime are largely shaped by transitional periods such as puberty, menopause and pregnancy, while daily fluctuations in microbial composition observed through culture-independent studies are more likely to be the results of daily life activities and behaviours. The vaginal microbiota of reproductive-aged women is largely made up of at least five different community state types. Four of these community state types are dominated by lactic-acid producing Lactobacillus spp. while the fifth is commonly composed of anaerobes and strict anaerobes and is sometimes associated with vaginal symptoms. The production of lactic acid has been associated with contributing to the overall health of the vagina due to its direct and indirect effects on pathogens and host defence. Some species associated with non-Lactobacillus vaginal microbiota may trigger immune responses as well as degrade the host mucosa, processes that ultimately increase susceptibility to infections and contribute to negative reproductive outcomes such as infertility and preterm birth. Further studies are needed to better understand the functional underpinnings of how the vaginal microbiota affect host physiology but also how host physiology affects the vaginal microbiota. Understanding this fine-tuned interaction is key to maintaining women's reproductive health. © 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.

Impact of UV-B radiation on photosynthetic assimilation of 14C-bicarbonate and inorganic 15N-compounds by cyanobacteria

International Nuclear Information System (INIS)

Doehler, G.; Biermann, I.; Zink, J.

1986-01-01

The cyanobacteria Anabaena cylindrica and Synechococcus leopoliensis (=Anacystis nidulans) were grown at different levels of UV-B radiation (439, 717, 1230 and 1405 J m -2 d -1 , weighted according Caldwell, 1971) for 2 days. Dry weight was hardly affected but phycocyanin content of both species decreased linearly to the level of UV-B radiation. Contents of protein, carotenoids and chlorophyll a were reduced only after exposure to high doses (1230 J m -2 d -1 ) of UV-B radiation. Photosynthetic 14 CO 2 fixation of Anabaena cells was reduced linearly with increasing UV-B dose whereas no effect could be observed in Synechococcus. A depression of photosynthetic 15 N-nitrate uptake was found after UV-B stress in both species. UV-B irradiance caused an increase of 15 N-incorporation into glutamine, but no effect was noted for incorporation into alanine or aspartic acid. An increase of 15 N-excess in glutamic acid linear with the UV-B dose was observed in Synechococcus, only. Patterns of 14 C-labelled photosynthetic products were either less affected by UV-B radiation (Anabaena) or an enhancement of 14 C-label in total amino acids was detected (Synechococcus). The amount of total free amino acids increased parallel to the level of UV-B radiation. Only, the high dose of UV-B (1405 J m -2 d -1 , weighted) results in a decrease of the glutamine pool. Our results indicate an inhibition of glutamate synthase by UV-B irradiation in Anabaena, only. Results were discussed with reference to the damage of the photosynthetic apparatus. (orig.)

Rac1 modification by an electrophilic 15-deoxy Δ12,14-prostaglandin J2 analog

Directory of Open Access Journals (Sweden)

S.B. Wall

2015-04-01

Full Text Available Vascular endothelial cells (ECs are important for maintaining vascular homeostasis. Dysfunction of ECs contributes to cardiovascular diseases, including atherosclerosis, and can impair the healing process during vascular injury. An important mediator of EC response to stress is the GTPase Rac1. Rac1 responds to extracellular signals and is involved in cytoskeletal rearrangement, reactive oxygen species generation and cell cycle progression. Rac1 interacts with effector proteins to elicit EC spreading and formation of cell-to-cell junctions. Rac1 activity has recently been shown to be modulated by glutathiolation or S-nitrosation via an active site cysteine residue. However, it is not known whether other redox signaling compounds can modulate Rac1 activity. An important redox signaling mediator is the electrophilic lipid, 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2. This compound is a downstream product of cyclooxygenase and forms covalent adducts with specific cysteine residues, and induces cellular signaling in a pleiotropic manner. In this study, we demonstrate that a biotin-tagged analog of 15d-PGJ2 (bt-15d-PGJ2 forms an adduct with Rac1 in vitro at the C157 residue, and an additional adduct was detected on the tryptic peptide associated with C178. Rac1 modification in addition to modulation of Rac1 activity by bt-15d-PGJ2 was observed in cultured ECs. In addition, decreased EC migration and cell spreading were observed in response to the electrophile. These results demonstrate for the first time that Rac1 is a target for 15d-PGJ2 in ECs, and suggest that Rac1 modification by electrophiles such as 15d-PGJ2 may alter redox signaling and EC function.

Using physiologically based models for clinical translation: predictive modelling, data interpretation or something in-between?

Science.gov (United States)

Niederer, Steven A; Smith, Nic P

2016-12-01

Heart disease continues to be a significant clinical problem in Western society. Predictive models and simulations that integrate physiological understanding with patient information derived from clinical data have huge potential to contribute to improving our understanding of both the progression and treatment of heart disease. In particular they provide the potential to improve patient selection and optimisation of cardiovascular interventions across a range of pathologies. Currently a significant proportion of this potential is still to be realised. In this paper we discuss the opportunities and challenges associated with this realisation. Reviewing the successful elements of model translation for biophysically based models and the emerging supporting technologies, we propose three distinct modes of clinical translation. Finally we outline the challenges ahead that will be fundamental to overcome if the ultimate goal of fully personalised clinical cardiac care is to be achieved. © 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.

The effects of a single whole body cryotherapy exposure on physiological, performance and perceptual responses of professional academy soccer players following repeated sprint exercise

OpenAIRE

Russell, Mark; Birch, Jack; Love, Thomas; Cook, Christian; Bracken, Richard M.; Taylor, Tom; Swift, Eamon; Cockburn, Emma; Finn, Charlie; Cunningham, Daniel; Wilson, Laura; Kilduff, Liam P.

2017-01-01

In professional youth soccer players, the physiological, performance and perceptual effects of a single whole body cryotherapy (WBC) session performed shortly after repeated sprint exercise were investigated. In a randomized, counter-balanced and crossover design, 14 habituated English Premier League academy soccer players performed 15 x 30 m sprints (each followed by a 10 m forced deceleration) on two occasions. Within 20 min of exercise cessation, players entered a WBC chamber (Cryo: 30 s a...

Smoke produced from plants waste material elicits growth of wheat (Triticum aestivum L. by improving morphological, physiological and biochemical activity

Directory of Open Access Journals (Sweden)

Muhammad Iqbal

2018-03-01

Full Text Available The experimental work presented in this study was carried out with the hypothesis that plant derived smoke enhanced the morphological, physiological and biochemical attributes of a cereal crop, wheat (Triticum aestivum L.. Furthermore, this study supported the hypothesis that plant derived smoke acts as vegetative growth promoter, inexpensive, rapid and most appropriate eco-friendly bio-fertilizer for sustainable agriculture. Plant derived smoke was generated by burning of plant material (leaf, straws etc in a specially designed furnace, and seeds were treated with this smoke for different time duration. Four level of plant derived smoke (1 h, 2 h, 3 h and 4 h along with control were tested on four wheat cultivars in CRD repeated pot experiment. The smoke-related treatments modified number of morphological, physiological and biochemical features of wheat. Compared with the control, aerosol smoke treatment of the seeds significantly improved root length (2.6%, shoot length (7.7%, RFW (0.04%, SFW (0.7%, SDW (0.1% and leaf area (63.9%. All the smoke-related treatments significantly promoted RWC (17.3%, water potential (1.5%, osmotic potential (1.4% and MSI (14.6% whereas a pronounced increase in chlorophyll a (24.9%, chlorophyll b (21.7% and total chlorophyll contents (15.5% were recorded in response to aerosol-smoke treatments. Plant derived smoke exposure applied for short time i.e. 1 h & 2 h induced significant results as compared to prolonged PDS exposure (3 h and 4 h. The best results were observed in Pak-13 and Glaxy-13 wheat cultivars. These findings indicated that the plant-derived smoke treatment has a great potential to improve morphological, physiological and biochemical features of wheat crop.

15. international conference on plant growth substances: Program -- Abstracts

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-12-31

Since the 14th Conference in Amsterdam in 1991, progress in plant hormone research and developmental plant biology has been truly astonishing. The five ``classical`` plant hormones, auxin, gibberellin, cytokinin, ethylene, and abscisic acid, have been joined by a number of new signal molecules, e.g., systemin, jasmonic acid, salicylic acid, whose biosynthesis and functions are being understood in ever greater detail. Molecular genetics has opened new vistas in an understanding of transduction pathways that regulate developmental processes in response to hormonal and environmental signals. The program of the 15th Conference includes accounts of this progress and brings together scientists whose work focuses on physiological, biochemical, and chemical aspects of plant growth regulation. This volume contains the abstracts of papers presented at this conference.

Variable setpoint as a relaxing component in physiological control.

Science.gov (United States)

Risvoll, Geir B; Thorsen, Kristian; Ruoff, Peter; Drengstig, Tormod

2017-09-01

Setpoints in physiology have been a puzzle for decades, and especially the notion of fixed or variable setpoints have received much attention. In this paper, we show how previously presented homeostatic controller motifs, extended with saturable signaling kinetics, can be described as variable setpoint controllers. The benefit of a variable setpoint controller is that an observed change in the concentration of the regulated biochemical species (the controlled variable) is fully characterized, and is not considered a deviation from a fixed setpoint. The variation in this biochemical species originate from variation in the disturbances (the perturbation), and thereby in the biochemical species representing the controller (the manipulated variable). Thus, we define an operational space which is spanned out by the combined high and low levels of the variations in (1) the controlled variable, (2) the manipulated variable, and (3) the perturbation. From this operational space, we investigate whether and how it imposes constraints on the different motif parameters, in order for the motif to represent a mathematical model of the regulatory system. Further analysis of the controller's ability to compensate for disturbances reveals that a variable setpoint represents a relaxing component for the controller, in that the necessary control action is reduced compared to that of a fixed setpoint controller. Such a relaxing component might serve as an important property from an evolutionary point of view. Finally, we illustrate the principles using the renal sodium and aldosterone regulatory system, where we model the variation in plasma sodium as a function of salt intake. We show that the experimentally observed variations in plasma sodium can be interpreted as a variable setpoint regulatory system. © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

Activity coefficients at infinite dilution of organic solutes in the ionic liquid trihexyl(tetradecyl)phosphonium tetrafluoroborate using gas-liquid chromatography at T = (313.15, 333.15, 353.15, and 373.15) K

International Nuclear Information System (INIS)

Tumba, Kaniki; Reddy, Prashant; Naidoo, Paramespri; Ramjugernath, Deresh

2011-01-01

Research highlights: → Activity coefficients at infinite dilution in the ionic liquid [3C 6 C 14 P][BF 4 ]. → Twenty-seven solutes investigated at T = (313.15, 333.15, 353.15, and 373.15) K. → [3C 6 C 14 P][BF 4 ] shows promise for the separation of aromatic and alcohol mixtures. - Abstract: Activity coefficients at infinite dilution have been measured by gas-liquid chromatography for 27 organic solutes (n-alkanes, 1-alkenes, 1-alkynes, cycloalkanes, aromatics, alcohols, and ketones) in the ionic liquid trihexyl(tetradecyl)phosphonium tetrafluoroborate [3C 6 C 14 P][BF 4 ]. The measurements were carried out at four different temperatures viz.T = (313.15, 333.15, 353.15, and 373.15) K. From the experimental data, partial molar excess enthalpy values at infinite dilution were calculated for the experimental temperature range. The selectivity values for the separation of n-hexane/benzene, cyclohexane/benzene, and methanol/benzene mixtures were determined from the experimental infinite dilution activity coefficient values. These values were compared to those available in the literature for other ionic liquids and commercial solvents, so as to assess the feasibility of employing [3C 6 C 14 P][BF 4 ] in solvent-enhanced industrial separations.

Significant Influences on Nature Experiences: A Comparative Study of Southern German and Northern Spanish Pupils Aged 14-15

Science.gov (United States)

Zecha, Stefanie

2015-01-01

An understanding of the current situation of nature experiences among adolescents is of critical importance for the protection of nature. The participants of this study are 14-15 year-old pupils from Bavaria (Southern Germany) and Asturias (Northern Spain). In particular, the author was interested in a) the level of outdoor experiences of each…

Structure-function relations in physiology education: Where's the mechanism?

Science.gov (United States)

Lira, Matthew E; Gardner, Stephanie M

2017-06-01

Physiology demands systems thinking: reasoning within and between levels of biological organization and across different organ systems. Many physiological mechanisms explain how structures and their properties interact at one level of organization to produce emergent functions at a higher level of organization. Current physiology principles, such as structure-function relations, selectively neglect mechanisms by not mentioning this term explicitly. We explored how students characterized mechanisms and functions to shed light on how students make sense of these terms. Students characterized mechanisms as 1 ) processes that occur at levels of organization lower than that of functions; and 2 ) as detailed events with many steps involved. We also found that students produced more variability in how they characterized functions compared with mechanisms: students characterized functions in relation to multiple levels of organization and multiple definitions. We interpret these results as evidence that students see mechanisms as holding a more narrow definition than used in the biological sciences, and that students struggle to coordinate and distinguish mechanisms from functions due to cognitive processes germane to learning in many domains. We offer the instructional suggestion that we scaffold student learning by affording students opportunities to relate and also distinguish between these terms so central to understanding physiology. Copyright © 2017 the American Physiological Society.

Nuclear energy: a world of service to humanity. 27th annual conference of the Canadian Nuclear Society and 30th Canadian Nuclear Society/Canadian Nuclear Association student conference

International Nuclear Information System (INIS)

2006-01-01

The 27th Annual conference of the Canadian Nuclear Society was held on June 11-14, 2006 in Toronto, Ontario, Canada. The conference gathered close to 400 scientists, engineers, technologists and students interested in all aspects and applications of energy from the atom. The central objective of this conference was to provide a forum for exchange of views on how this technical enterprise can best serve the needs of humanity, now and in the future. The plenary sessions addressed broad industrial and commercial developments in the field. Over eighty papers were presented in 15 technical sessions on the following topics: safety analysis; plant refurbishment; control room operation; nuclear chemistry and materials; advanced reactor design; plant operation; reactor physics; safety analysis; nuclear instrumentation; and, nuclear general topics. Embedded in the conference was the 30th student conference, sponsored by the Canadian Nuclear Society and the Canadian Nuclear Association. Over thirty-five papers were presented in five sessions on the following topics: corrosion processes; control systems / physics / modelling; and, chemistry / chemical engineering

The Graphical Representation of the Digital Astronaut Physiology Backbone

Science.gov (United States)

Briers, Demarcus

2010-01-01

This report summarizes my internship project with the NASA Digital Astronaut Project to analyze the Digital Astronaut (DA) physiology backbone model. The Digital Astronaut Project (DAP) applies integrated physiology models to support space biomedical operations, and to assist NASA researchers in closing knowledge gaps related to human physiologic responses to space flight. The DA physiology backbone is a set of integrated physiological equations and functions that model the interacting systems of the human body. The current release of the model is HumMod (Human Model) version 1.5 and was developed over forty years at the University of Mississippi Medical Center (UMMC). The physiology equations and functions are scripted in an XML schema specifically designed for physiology modeling by Dr. Thomas G. Coleman at UMMC. Currently it is difficult to examine the physiology backbone without being knowledgeable of the XML schema. While investigating and documenting the tags and algorithms used in the XML schema, I proposed a standard methodology for a graphical representation. This standard methodology may be used to transcribe graphical representations from the DA physiology backbone. In turn, the graphical representations can allow examination of the physiological functions and equations without the need to be familiar with the computer programming languages or markup languages used by DA modeling software.

Complete fusion of the 12C+12O, 14N+12C and 15N+12C systems

International Nuclear Information System (INIS)

Conjeaud, M.; Gary, S.; Harar, S.; Wieleczko, J.P.

1978-01-01

Cross sections for evaporation residues following the complete fusion of the 12 C+ 12 C, 14 N+ 12 C and 15 N+ 12 C systems have been measured with a E-ΔE counter telescope in a wide range of incident energies. They are fairly well reproduced by evaporation calculations based on the statistical theory. The total fusion excitation function of the 12 C+ 12 C system shows strong structure, which is compared to the predictions of the reaction cross sections derived from coupled channel calculations and to the integrated inelastic cross sections. Critical angular momenta have been obtained from the fusion cross-section data and these values are discussed in the framework of compound nucleus and entrance channel effects. A striking difference is observed between the fusion cross sections of the 14 N+ 12 C and 15 N+ 12 C systems and shows the importance of the valence nucleons of colliding ions in the fusion process. A possible interpretation might be the influence of the yrast line of the compound nuclei. (Auth.)

VizieR Online Data Catalog: Discovery of 2 hot Jupiters KELT-14b & KELT-15b (Rodriguez+, 2016)

Science.gov (United States)

Rodriguez, J. E.; Colon, K. D.; Stassun, K. G.; Wright, D.; Cargile, P. A.; Bayliss, D.; Pepper, J.; Collins, K. A.; Kuhn, R. B.; Lund, M. B.; Siverd, R. J.; Zhou, G.; Gaudi, B. S.; Tinney, C. G.; Penev, K.; Tan, T. G.; Stockdale, C.; Curtis, I. A.; James, D.; Udry, S.; Segransan, D.; Bieryla, A.; Latham, D. W.; Beatty, T. G.; Eastman, J. D.; Myers, G.; Bartz, J.; Bento, J.; Jensen, E. L. N.; Oberst, T. E.; Stevens, D. J.

2018-04-01

Spectroscopic observations of KELT-14 and KELT-15 were carried out using the CYCLOPS2 fiber feed with the UCLES spectrograph instrument on the Anglo-Australian Telescope (AAT) over two observing runs: UT 2015 February 02-UT 2015 March 01 and UT 2015 May 6-UT 2015 May 13. The instrumental set-up and observing strategy for these observations closely follow that described in earlier CYCLOPS RV papers (Addison et al. 2013ApJ...774L...9A, 2014ApJ...792..112A). CORALIE is a fiber-fed echelle spectrograph (Queloz et al. 2001Msngr.105....1Q) attached to the Swiss 1.2 m Leonard Euler telescope at the ESO La Silla Observatory in Chile. It has a spectral resolution of R~60000, a wavelength range of 3900-6800 Å, and is able to measure radial velocities of bright stars to a precision of 3 m/s or better (Pepe et al. 2002, J/A+A/388/632). We obtained spectra at five epochs of KELT-15 from UT 2015 September 02 to UT 2015 September 14. (3 data files).

Anthropometric and physiological characteristics of Melanesian futsal players: a first approach to talent identification in Oceania

Directory of Open Access Journals (Sweden)

Olivier Galy

2015-02-01

Full Text Available This study assessed the anthropometric and physiological characteristics of elite Melanesian futsal players in order to determine the best performance predictors. Physiological parameters of performance were measured in 14 Melanesian (MEL-G, 24.4±4.4 yrs and 8 Caucasian (NMEL-G, 22.9±4.9 elite futsal players, using tests of jump-and-reach (CMJ, agility (T-Test, repeated sprint ability (RSA, RSA with change-of-direction (RSA-COD, sprints with 5 m, 10 m, 15 m, and 30 m lap times, and aerobic fitness with the 30-15 intermittent fitness test (30-15 IFT. The anthropometric data revealed significantly lower height for MEL-G compared with NMEL-G: 1.73±0.05 and 1.80±0.08 m, respectively; P=0.05. The CMJ was significantly higher for MEL-G than NMEL-G: 50.4±5.9 and 45.2±4.3 cm, respectively; P=0.05. T-Test times were significantly lower for MEL-G than NMEL-G: 10.47±0.58 and 11.01±0.64 seconds, respectively; P=0.05. MEL-G height was significantly related to CMJ (r=0.706, P=0.01, CMJ peakP (r=0.709, P=0.01 and T-Test (r=0.589, P=0.02. No significant between-group differences were observed for sprint tests or 30-15 IFT, including heart rate and estimated VO 2max . Between groups, the percentage decrement (%Dec in RSA-COD was significantly lower in MEL-G than NMEL-G (P=0.05, although no significant difference was noted between RSA and RSA-COD. Within groups, no significant difference was observed between %Dec in RSA or RSA-COD; P=0.697. This study presents specific anthropometric (significantly lower height and physiological (significantly greater agility reference values in Melanesians, which, taken together, might help coaches and physical fitness trainers to optimize elite futsal training and talent identification in Oceania.

The Trojan Horse Method as a tool to investigate low-energy resonances: the 18O(p, α)15N and 17O(p, α)14N cases

International Nuclear Information System (INIS)

La Cognata, M.; Sergi, M. L.; Spitaleri, C.; Cherubini, S.; Gulino, M.; Kiss, G.; Lamia, L.; Pizzone, R. G.; Romano, S.; Mukhamedzhanov, A.; Goldberg, V.; Tribble, R.; Coc, A.; Hammache, F.; Sereville, N. de; Irgaziev, B.; Tumino, A.

2010-01-01

The 18 O(p, α) 15 N and 17 O(p, α) 14 N reactions are of primary importance in several as-trophysical scenarios, including nucleosynthesis inside Asymptotic Giant Branch stars and oxygen and nitrogen isotopic ratios in meteorite grains. They are also key reactions to understand exotic systems such as R-Coronae Borealis stars and novae. Thus, the measurement of their cross sections in the low energy region can be crucial to reduce the nuclear uncertainty on theoretical predictions, because the resonance parameters are poorly determined. The Trojan Horse Method, in its newly developed form particularly suited to investigate low-energy resonances, has been applied to the 2 H( 18 O, α 15 N)n and 2 H( 17 O, α 14 N)n reactions to deduce the 18 O(p, α) 15 N and 17 O(p, α) 14 N cross sections at low energies. Resonances in the 18 O(p, α) 15 N and 17 O(p, α) 14 N excitation functions have been studied and the resonance parameters deduced.

Physical and Physiological Demands of Recreational Team Handball for Adult Untrained Men.

Science.gov (United States)

Póvoas, Susana C A; Castagna, Carlo; Resende, Carlos; Coelho, Eduardo Filipe; Silva, Pedro; Santos, Rute; Seabra, André; Tamames, Juan; Lopes, Mariana; Randers, Morten Bredsgaard; Krustrup, Peter

2017-01-01

Lack of motivation to exercise was reported as a major cause of sedentary behavior in adulthood. This descriptive study examines the acute physical and physiological demands of recreational team handball and evaluates whether it could be suggested as an exercise mode for fitness and health enhancement in 33-55-year-old untrained men. Time-motion, heart rate (HR), and blood lactate analyses were obtained from 4 recreational matches. Mean distance covered during the 60 min matches was 6012 ± 428 m. The players changed match activity 386 ± 70 times, of which high-intensity runs and unorthodox movements amounted to 59 ± 18 and 26 ± 26 per match, respectively. The most frequent highly demanding playing actions were jumps and throws. Match average and peak HR were 82 ± 6% and 93 ± 5%  HR max , respectively. Players exercised at intensities between 81 and 90%  HR max for 47% (28 ± 14 min) and >90%  HR max for 24% (14 ± 15 min) of total match time. Match average and peak blood lactate values were 3.6 ± 1.3 and 4.2 ± 1.2 mM, respectively. Recreational team handball is an intermittent high-intensity exercise mode with physical and physiological demands in the range of those found to have a positive effect on aerobic, anaerobic, and musculoskeletal fitness in adult individuals. Training studies considering recreational team handball as a health enhancing intervention are warranted.

Physical and Physiological Demands of Recreational Team Handball for Adult Untrained Men

Directory of Open Access Journals (Sweden)

Susana C. A. Póvoas

2017-01-01

Full Text Available Lack of motivation to exercise was reported as a major cause of sedentary behavior in adulthood. This descriptive study examines the acute physical and physiological demands of recreational team handball and evaluates whether it could be suggested as an exercise mode for fitness and health enhancement in 33–55-year-old untrained men. Time-motion, heart rate (HR, and blood lactate analyses were obtained from 4 recreational matches. Mean distance covered during the 60 min matches was 6012±428 m. The players changed match activity 386±70 times, of which high-intensity runs and unorthodox movements amounted to 59±18 and 26±26 per match, respectively. The most frequent highly demanding playing actions were jumps and throws. Match average and peak HR were 82±6% and 93±5%  HRmax, respectively. Players exercised at intensities between 81 and 90%  HRmax for 47% (28±14 min and >90%  HRmax for 24% (14±15 min of total match time. Match average and peak blood lactate values were 3.6±1.3 and 4.2±1.2 mM, respectively. Recreational team handball is an intermittent high-intensity exercise mode with physical and physiological demands in the range of those found to have a positive effect on aerobic, anaerobic, and musculoskeletal fitness in adult individuals. Training studies considering recreational team handball as a health enhancing intervention are warranted.

15-Deoxy-Δ12,14-prostaglandin J2 inhibits macrophage colonization by Salmonella enterica serovar Typhimurium.

Directory of Open Access Journals (Sweden)

Michelle M C Buckner

Full Text Available 15-deoxy-Δ(12,14-prostaglandin J2 (15d-PGJ2 is an anti-inflammatory downstream product of the cyclooxygenase enzymes. It has been implicated to play a protective role in a variety of inflammatory mediated diseases, including rheumatoid arthritis, neural damage, and myocardial infarctions. Here we show that 15d-PGJ2 also plays a role in Salmonella infection. Salmonella enterica Typhimurium is a Gram-negative facultative intracellular pathogen that is able to survive and replicate inside phagocytic immune cells, allowing for bacterial dissemination to systemic sites. Salmonella species cause a wide range of morbidity and mortality due to gastroenteritis and typhoid fever. Previously we have shown that in mouse models of typhoid fever, Salmonella infection causes a major perturbation in the prostaglandin pathway. Specifically, we saw that 15d-PGJ2 production was significantly increased in both liver and feces. In this work we show that 15d-PGJ2 production is also significantly increased in macrophages infected with Salmonella. Furthermore, we show that the addition of 15d-PGJ2 to Salmonella infected RAW264.7, J774, and bone marrow derived macrophages is sufficient to significantly reduce bacterial colonization. We also show evidence that 15d-PGJ2 is reducing bacterial uptake by macrophages. 15d-PGJ2 reduces the inflammatory response of these infected macrophages, as evidenced by a reduction in the production of cytokines and reactive nitrogen species. The inflammatory response of the macrophage is important for full Salmonella virulence, as it can give the bacteria cues for virulence. The reduction in bacterial colonization is independent of the expression of Salmonella virulence genes SPI1 and SPI2, and is independent of the 15d-PGJ2 ligand PPAR-γ. 15d-PGJ2 also causes an increase in ERK1/2 phosphorylation in infected macrophages. In conclusion, we show here that 15d-PGJ2 mediates the outcome of bacterial infection, a previously unidentified

A day of immersive physiology experiments increases knowledge and excitement towards physiology and scientific careers in Native American students.

Science.gov (United States)

Becker, Bryan K; Schiller, Alicia M; Zucker, Irving H; Eager, Eric A; Bronner, Liliana P; Godfrey, Maurice

2017-03-01

Underserved minority groups are disproportionately absent from the pursuit of careers in science, technology, engineering, and mathematics (STEM) fields. One such underserved population, Native Americans, are particularly underrepresented in STEM fields. Although recent advocacy and outreach designed toward increasing minority involvement in health care-related occupations have been mostly successful, little is known about the efficacy of outreach programs in increasing minority enthusiasm toward careers in traditional scientific professions. Furthermore, very little is known about outreach among Native American schools toward increasing involvement in STEM. We collaborated with tribal middle and high schools in South Dakota and Nebraska through a National Institutes of Health Science Education Partnership Award to hold a day-long physiology, activity-based event to increase both understanding of physiology and enthusiasm to scientific careers. We recruited volunteer biomedical scientists and trainees from the University of Nebraska Medical Center, Nebraska Wesleyan University, and University of South Dakota. To evaluate the effectiveness of the day of activities, 224 of the ~275-300 participating students completed both a pre- and postevent evaluation assessment. We observed increases in both students self-perceived knowledge of physiology and enthusiasm toward scientific career opportunities after the day of outreach activities. We conclude that activity-based learning opportunities in underserved populations are effective in increasing both knowledge of science and interest in scientific careers. Copyright © 2017 the American Physiological Society.

1,5-Diphenyl-1,4-pentadiene-3-ones and cyclic analogues as antioxidative agents. Synthesis and structure-activity relationship.

NARCIS (Netherlands)

Sardjiman, S.S.; Reksohadiprodjo, M.S.; Hakim, L.; van der Goot, H.; Timmerman, H.

1997-01-01

A series of 1,5-diphenyl-1,4-pentadiene-3-ones and cyclic analogues with OH-groups in the para position of the phenyl rings and various meta substituents were prepared and their antioxidant activity compared with that of curcumin. Most of them exhibited potent antioxidative activity, especially when

Acoustical Studies of Some Schiff Bases in 1,4-Dioxane and Dimethylformamide at 318.15 K

Institute of Scientific and Technical Information of China (English)

BALUJA Shipra

2006-01-01

From experimental data of density, viscosity and ultrasonic velocity, the various acoustical properties, such as specific impedance (Z), isentropic compressibility (κs), Rao's molar sound function (Rm), the van der Waals constant (b), molar compressibility (W), intermolecular free length (Lf), relaxation strength (r), internal pressure (π),free volume (Vf), solvation number (Sn) etc., were calculated for three Schiff bases in 1,4-dioxane and dimethylformamide (DMF) at 318.15 K. The results are interpreted in terms of molecular interactions occurring in the solutions.

High-resolution Fourier-transform extreme ultraviolet photoabsorption spectroscopy of 14N15N

Science.gov (United States)

Heays, A. N.; Dickenson, G. D.; Salumbides, E. J.; de Oliveira, N.; Joyeux, D.; Nahon, L.; Lewis, B. R.; Ubachs, W.

2011-12-01

The first comprehensive high-resolution photoabsorption spectrum of 14N15N has been recorded using the Fourier-transform spectrometer attached to the Desirs beamline at the Soleil synchrotron. Observations are made in the extreme ultraviolet and span 100 000-109 000 cm-1 (100-91.7 nm). The observed absorption lines have been assigned to 25 bands and reduced to a set of transition energies, f values, and linewidths. This analysis has verified the predictions of a theoretical model of N2 that simulates its photoabsorption and photodissociation cross section by solution of an isotopomer independent formulation of the coupled-channel Schrödinger equation. The mass dependence of predissociation linewidths and oscillator strengths is clearly evident and many local perturbations of transition energies, strengths, and widths within individual rotational series have been observed.

New concepts in white adipose tissue physiology

International Nuclear Information System (INIS)

Proença, A.R.G.; Sertié, R.A.L.; Oliveira, A.C.; Campaãa, A.B.; Caminhotto, R.O.; Chimin, P.; Lima, F.B.

2014-01-01

Numerous studies address the physiology of adipose tissue (AT). The interest surrounding the physiology of AT is primarily the result of the epidemic outburst of obesity in various contemporary societies. Briefly, the two primary metabolic activities of white AT include lipogenesis and lipolysis. Throughout the last two decades, a new model of AT physiology has emerged. Although AT was considered to be primarily an abundant energy source, it is currently considered to be a prolific producer of biologically active substances, and, consequently, is now recognized as an endocrine organ. In addition to leptin, other biologically active substances secreted by AT, generally classified as cytokines, include adiponectin, interleukin-6, tumor necrosis factor-alpha, resistin, vaspin, visfatin, and many others now collectively referred to as adipokines. The secretion of such biologically active substances by AT indicates its importance as a metabolic regulator. Cell turnover of AT has also recently been investigated in terms of its biological role in adipogenesis. Consequently, the objective of this review is to provide a comprehensive critical review of the current literature concerning the metabolic (lipolysis, lipogenesis) and endocrine actions of AT

New concepts in white adipose tissue physiology

Energy Technology Data Exchange (ETDEWEB)

Proença, A.R.G. [Universidade Estadual de Campinas, Laboratório de Biotecnologia, Faculdade de Ciências Aplicadas, Limeira, SP, Brasil, Laboratório de Biotecnologia, Faculdade de Ciências Aplicadas, Universidade Estadual de Campinas, Limeira, SP (Brazil); Sertié, R.A.L. [Universidade de São Paulo, Instituto de Ciências Biomédicas, Departamento de Fisiologia e Biofísica, São Paulo, SP, Brasil, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP (Brazil); Oliveira, A.C. [Universidade Estadual do Ceará, Instituto Superior de Ciências Biomédicas, Fortaleza, CE, Brasil, Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Fortaleza, CE (Brazil); Campaãa, A.B.; Caminhotto, R.O.; Chimin, P.; Lima, F.B. [Universidade de São Paulo, Instituto de Ciências Biomédicas, Departamento de Fisiologia e Biofísica, São Paulo, SP, Brasil, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP (Brazil)

2014-03-03

Numerous studies address the physiology of adipose tissue (AT). The interest surrounding the physiology of AT is primarily the result of the epidemic outburst of obesity in various contemporary societies. Briefly, the two primary metabolic activities of white AT include lipogenesis and lipolysis. Throughout the last two decades, a new model of AT physiology has emerged. Although AT was considered to be primarily an abundant energy source, it is currently considered to be a prolific producer of biologically active substances, and, consequently, is now recognized as an endocrine organ. In addition to leptin, other biologically active substances secreted by AT, generally classified as cytokines, include adiponectin, interleukin-6, tumor necrosis factor-alpha, resistin, vaspin, visfatin, and many others now collectively referred to as adipokines. The secretion of such biologically active substances by AT indicates its importance as a metabolic regulator. Cell turnover of AT has also recently been investigated in terms of its biological role in adipogenesis. Consequently, the objective of this review is to provide a comprehensive critical review of the current literature concerning the metabolic (lipolysis, lipogenesis) and endocrine actions of AT.

Use of urinary 13,14, dihydro-15-keto-prostaglandin F2α (PGFM concentrations to diagnose pregnancy and predict parturition in the giant panda (Ailuropoda melanolecua.

Directory of Open Access Journals (Sweden)

Beth M Roberts

Full Text Available Pregnancy determination is difficult in the giant panda (Ailuropoda melanolecua, representing a challenge for ex situ conservation efforts. Research in other species experiencing pseudopregnancy indicates that urinary/fecal concentrations of 13,14, dihydro-15-keto-prostaglandin F2α (PGFM can accurately determine pregnancy status. Our objective was to determine if urinary PGFM concentrations are associated with pregnancy status in the giant panda. Urinary PGFM concentrations were measured in female giant pandas (n = 4 throughout gestation (n = 6 and pseudopregnancy (n = 4 using a commercial enzyme immunoassay. Regardless of pregnancy status, PGFM excretion followed a predictable pattern: 1 baseline concentrations for 11-19 weeks following ovulation; 2 a modest, initial peak 14-36 days after the start of the secondary urinary progestagen rise; 3 a subsequent period of relatively low concentrations; and 4 a large, terminal peak at the end of the luteal phase. Pregnant profiles were distinguished by an earlier initial peak (P = 0.024, higher inter-peak concentrations (P < 0.001, and a larger terminal peak (P = 0.003 compared to pseudopregnancy profiles. Parturition occurred 23 to 25 days from the initial PGFM surge and within 24 hours of the start of the terminal increase. These pattern differences indicate that urinary PGFM monitoring can be used to predict pregnancy status and time parturition in the giant panda. Furthermore, this is the only species known to exhibit a significant PGFM increase during pseudopregnancy, suggesting a unique physiological mechanism for regulating the end of the luteal phase in the giant panda.

Study on the metabolism of 15 p-131iodine phenyl pentadecanoic acid [p-iodine phenyl pentadecanoic acid] as a tracer of free fatty acids in comparison to 1-14C-palmitic acid (C-palmitic acid)

International Nuclear Information System (INIS)

Sauer, J.W.

1986-01-01

In an animal experiment under identical metabolic influences the metabolism of a new radiopharmaceutical, 15 p- 131 iodine phenyl pentadecanoic acid (IPPA), was compared to the marked physiological fatty acid, 1- 14 C-palmitic acid (PA). The pharmacological kinetics of both tracers in tissues with widely varied turnover rates of fatty acids (heart, lung, liver, kidney, spleen, small intestine, skeletal muscle) was studied. By alkali extraction of the tissue lipids and then a chromatographic separation of the lipid fractions quantitatively comparable statements about the metabolism of PA and IPPA were made possible. The analyses of autoradiographs of the chromatographically separated lipids show a qualitatively congruous assimilation of both markers in the major lipid fractions. The quantitative evaluation shows minor differences as a result of a preferred assimilation of IPPA in triglycerides and of PA in phospholipids. The fractionated separation of tissue lipids which had been marked with PA and IPPA in vivo agrees very well with values which have been determined by other authors using 14 C- or 3 H-marked fatty acids. The close correlation of the tissue-specific metabolism kinetics of both markers makes it clear that both fatty acids are metabolized by similar, respectively, primarily identical metabolic pathyways. In conclusion, this study makes clear the extensive congruence of the metabolism kinetics of IPPA and the kinetics of the physiological palmitic acid. As a result of the presented results of the γ-radiating radiopharmaceutical IPPA as a free fatty acid analog new possibilities for the non-invasive external comprehension of lipid metabolism are opened up, whose use especially in the diagnostic of heart diseases promises success. (orig./MG) [de

Investigation on the absorption of /sup 14/C-leucine and /sup 15/N-leucine in rats after feeding a fish meal diet in comparison with a gelatine diet

Energy Technology Data Exchange (ETDEWEB)

Bergner, U; Adam, K; Bergner, H [Humboldt-Universitaet, Berlin (German Democratic Republic). Sektion Tierproduktion und Veterinaermedizin

1981-01-01

Albino rats received after nine days of adaptation to a fish meal diet in comparison with a gelatine diet /sup 14/C-U-L-leucine and /sup 15/N-L-leucine via a pellet made from the specific diet after food deprivation for 15 h. Thereafter, the animals consumed the non-labelled experimental diet ad libitum. 30 min, and 1, 2, 4 and 8 h, resp., after intake of the labelled food, four rats at a time were sacrificed. The contents of the digestive tract and tissue samples were examined for /sup 14/C and /sup 15/N and their percentages in the TCA-soluble fraction determined. If these values are regarded as non-absorbed leucine, the /sup 14/C values obtained up to the four hour period of the experiment would be too high. Presumably, they are in the case of both diets simulated by other /sup 14/C metabolites which originate from the leucine catabolism and reach the intestinal lumen. Amino acids labelled with /sup 15/N should be preferred in studies on the absorption of amino acids because, in case of catabolization, the /sup 15/N aminogroup is excreted mainly as urea via urine.

Physical and Physiological Profile of Elite Iranian Karate Athletes

Directory of Open Access Journals (Sweden)

Hassan Faraji

2017-01-01

Full Text Available No study to date, has investigated the physiologic and anthropometric of Iranian elite Karatekas profile. Forty men internationally ranked karatekas in kumite field took part in this study. They were selected for national camp for participation in world karate championships in Germany 2014. The anthropometric and physiological profiles were measured. The major results were as follows: body height (177.9±6.20 kg, weight (72.8±9.98 cm, BMI (23.2±2.36 kg/m2, fat mass (9.5±2.47 kg, lean body mass (64.1±8.89 kg, percentage of body fat (12.9±2.36, sitting height (95.1±4.21 cm, arm span (180.5±7.87 cm, sit and reach (38.7±5.71 cm, pull up (15.7±8.37 rep, shuttle run 4×9 m (8.4±0.28 sec, 40-yd sprint (5.0±0.16 sec, vertical jump Sargent (56.6±8.14 cm, standing broad jump (151.1±13.90 cm, peak power (957.5±164.11 W, anaerobic threshold (165.5±8.05 HR pm and visual reaction time (378.8±63.82 ms. Significant correlations occurred between peak power with weight, BMI, height, lean body mass, arm span and sitting height (r = 0.75, 0.70, 0.53, 0.77, 0.44, and 0.63, respectively. Also, both arm span and height was negatively correlated to standing broad jump results (r= -0.41 and -0.34, respectively (p< 0.05. These anthropometric and physiological profiles from elite Iranian Karatekas can be used in evaluating for talent identification and are important for the optimal construction of training programs the sport scientific, coaches and these athletes.

Nitrogen ligation to manganese in the photosynthetic oxygen-evolving complex: Continuous-wave and pulsed EPR studies of Photosystem II particles containing 14N or 15N

International Nuclear Information System (INIS)

DeRose, V.J.; Yachandra, V.K.; McDermott, A.E.; Britt, R.D.; Sauer, K.; Klein, M.P.

1991-01-01

The possibility of nitrogen ligation to the Mn in the oxygen-evolving complex from photosystem II was investigated with electron paramagnetic resonance (EPR) and electron spin echo envelope modulation (ESEEM) spectroscopies using 14 N- and 15 N-labeled preparations. Oxygen-evolving preparations were isolated from a thermophilic cyanobacterium, Synechococcus sp., grown on a medium containing either 14 NO 3 - or 15 NO - 3 as the sole source of nitrogen. The substructure on the multiline EPR signal, which arises from Mn in the S 2 state of the enzyme, was measured with continuous-wave EPR. No changes were detected in the substructure peak positions upon substitution of 15 N for 14 N, indicating that this substructure is not due to superhyperfine coupling from nitrogen ligands. To detect potential nitrogen ligands with superhyperfine couplings of lesser magnitude than could be observed with conventional EPR methods, electron spin-echo envelope modulation experiments were also performed on the multiline EPR signal. The Fourier transform of the light-minus-dark time domain ESEEM data shows a peak at 4.8 MHz in 14 N samples which is absent upon substitution with 15 N. This gives unambiguous evidence for weak hyperfine coupling of nitrogen to the Mn of the oxygen-evolving complex. Possible origins of this nitrogen interaction are discussed

{sup 15}N/{sup 14}N isotopic ratio and statistical analysis: an efficient way of linking seized Ecstasy tablets

Energy Technology Data Exchange (ETDEWEB)

Palhol, Fabien; Lamoureux, Catherine; Chabrillat, Martine; Naulet, Norbert

2004-05-10

In this study, the {sup 15}N/{sup 14}N isotopic ratios of 106 samples of 3,4-methylenedioxymethamphetamine (MDMA) extracted from Ecstasy tablets are presented. These ratios, measured using gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS), show a large discrimination between samples with a range of {delta}{sup 15}N values between -17 and +19%o, depending on the precursors and the method used in clandestine laboratories. Thus, {delta}{sup 15}N values can be used in a statistical analysis carried out in order to link Ecstasy tablets prepared with the same precursors and synthetic pathway. The similarity index obtained after principal component analysis and hierarchical cluster analysis appears to be an efficient way to group tablets seized in different places.

Radiological Protection in Transition. Proceedings of the 14. Regular Meeting of the Nordic Society for Radiation Protection, NSFS

Energy Technology Data Exchange (ETDEWEB)

Valentin, J; Cederlund, T; Drake, P; Finne, I E; Glansholm, A; Jaworska, A; Paile, W; Rahola, T [eds.

2005-09-01

These proceedings comprise the papers and posters presented at the 14th Regular Meeting of the Nordic Society for Radiation Protection, the theme of which was 'Radiological protection in transformation'. There were sessions on international developments and stakeholder involvement, on education, training, and measurements, on emergencies, on nuclear installations, on non-ionising radiation, on medical radiation, on industrial uses of radiation, on radiobiology, on natural sources of radiation, on non-nuclear waste, on NKS (Nordic Nuclear Safety Research), on radioecology and artificial radionuclides in the environment, and on regulatory and international activities. In addition to invited lectures and proffered papers, there were educational primer lessons in the mornings and several roundtable discussions. In all, there were almost 100 contributions from participants representing at least 10 different countries. The range of different topics covered, the scientific quality of the contributions, and the interest shown in this meeting reflect the high standing of radiological protection in the Nordic countries.

Radiological Protection in Transition. Proceedings of the 14. Regular Meeting of the Nordic Society for Radiation Protection, NSFS

International Nuclear Information System (INIS)

Valentin, J.; Cederlund, T.; Drake, P.; Finne, I.E.; Glansholm, A.; Jaworska, A.; Paile, W.; Rahola, T.

2005-09-01

These proceedings comprise the papers and posters presented at the 14th Regular Meeting of the Nordic Society for Radiation Protection, the theme of which was 'Radiological protection in transformation'. There were sessions on international developments and stakeholder involvement, on education, training, and measurements, on emergencies, on nuclear installations, on non-ionising radiation, on medical radiation, on industrial uses of radiation, on radiobiology, on natural sources of radiation, on non-nuclear waste, on NKS (Nordic Nuclear Safety Research), on radioecology and artificial radionuclides in the environment, and on regulatory and international activities. In addition to invited lectures and proffered papers, there were educational primer lessons in the mornings and several roundtable discussions. In all, there were almost 100 contributions from participants representing at least 10 different countries. The range of different topics covered, the scientific quality of the contributions, and the interest shown in this meeting reflect the high standing of radiological protection in the Nordic countries

Radiological Protection in Transition. Proceedings of the 14. Regular Meeting of the Nordic Society for Radiation Protection, NSFS

Energy Technology Data Exchange (ETDEWEB)

Valentin, J.; Cederlund, T.; Drake, P.; Finne, I.E.; Glansholm, A.; Jaworska, A.; Paile, W.; Rahola, T. (eds.)

2005-09-01

These proceedings comprise the papers and posters presented at the 14th Regular Meeting of the Nordic Society for Radiation Protection, the theme of which was 'Radiological protection in transformation'. There were sessions on international developments and stakeholder involvement, on education, training, and measurements, on emergencies, on nuclear installations, on non-ionising radiation, on medical radiation, on industrial uses of radiation, on radiobiology, on natural sources of radiation, on non-nuclear waste, on NKS (Nordic Nuclear Safety Research), on radioecology and artificial radionuclides in the environment, and on regulatory and international activities. In addition to invited lectures and proffered papers, there were educational primer lessons in the mornings and several roundtable discussions. In all, there were almost 100 contributions from participants representing at least 10 different countries. The range of different topics covered, the scientific quality of the contributions, and the interest shown in this meeting reflect the high standing of radiological protection in the Nordic countries.

A novel antipyretic action of 15-deoxy-Delta12,14-prostaglandin J2 in the rat brain.

Science.gov (United States)

Mouihate, Abdeslam; Boissé, Lysa; Pittman, Quentin J

2004-02-11

Fever is an important part of the host defense response, yet fever can be detrimental if it is uncontrolled. We provide the first evidence that 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2), an endogenous ligand for peroxisome proliferator-activated receptor gamma (PPARgamma), can attenuate the febrile response to lipopolysaccharide (LPS) in rats via an action on the brain. Furthermore, we show that PPARgamma is expressed in the hypothalamus, an important locus in the brain for fever generation. In addition, 15d-PGJ2 and its synthesizing enzyme (PGD2 synthase) were present in rat cerebrospinal fluid, and their levels were enhanced in response to systemic injection of LPS. The antipyretic effect of 15d-PGJ2 was associated with reduction in LPS-stimulated cyclooxygenase-2 expression in the hypothalamus but not in p44/p42 mitogen-activated protein kinase phosphorylation or in the expression of the PPARgamma. Thus it is likely that there is a parallel induction of an endogenous prostanoid pathway in the brain capable of limiting deleterious actions of the proinflammatory prostaglandin E2-dependent pathway.

Students' motivation toward laboratory work in physiology teaching.

Science.gov (United States)

Dohn, Niels Bonderup; Fago, Angela; Overgaard, Johannes; Madsen, Peter Teglberg; Malte, Hans

2016-09-01

The laboratory has been given a central role in physiology education, and teachers report that it is motivating for students to undertake experimental work on live animals or measuring physiological responses on the students themselves. Since motivation is a critical variable for academic learning and achievement, then we must concern ourselves with questions that examine how students engage in laboratory work and persist at such activities. The purpose of the present study was to investigate how laboratory work influences student motivation in physiology. We administered the Lab Motivation Scale to assess our students' levels of interest, willingness to engage (effort), and confidence in understanding (self-efficacy). We also asked students about the role of laboratory work for their own learning and their experience in the physiology laboratory. Our results documented high levels of interest, effort, and self-efficacy among the students. Correlation analyses were performed on the three motivation scales and exam results, yet a significant correlation was only found between self-efficacy in laboratory work and academic performance at the final exam. However, almost all students reported that laboratory work was very important for learning difficult concepts and physiological processes (e.g., action potential), as the hands-on experiences gave a more concrete idea of the learning content and made the content easier to remember. These results have implications for classroom practice as biology students find laboratory exercises highly motivating, despite their different personal interests and subject preferences. This highlights the importance of not replacing laboratory work by other nonpractical approaches, for example, video demonstrations or computer simulations. Copyright © 2016 The American Physiological Society.

Physiological characteristics of bacteria isolated from water brines within permafrost

Science.gov (United States)

Shcherbakova, V.; Rivkina, E.; Laurinavichuis, K.; Pecheritsina, S.; Gilichinsky, D.

2004-01-01

In the Arctic there are lenses of overcooled water brines (cryopegs) sandwiched within permafrost marine sediments 100 120 thousand years old. We have investigated the physiological properties of the pure cultures of anaerobic Clostridium sp. strain 14D1 and two strains of aerobic bacteria Psychrobacter sp. isolated from these cryopegs. The structural and physiological characteristics of new bacteria from water brines have shown their ability to survive and develop under harsh conditions, such as subzero temperatures and high salinity.

Physical and physiological characteristics in male team handball players by playing position - Does age matter?

Science.gov (United States)

Nikolaidis, P T; Ingebrigtsen, J; Póvoas, S C; Moss, S; Torres-Luque, G

2015-04-01

The purpose of this study was to examine the variation in physical and physiological characteristics according to playing position in adolescent and adult male team handball (TH) players. Adolescent (N.=57, aged 14.9±1.4 yr) and adult (N.=39, 26.6±5.7 yr) players were examined for anthropometric characteristics, somatotype and body composition, and performed the physical working capacity test, a force-velocity test, the Wingate anaerobic test (WAnT), sit-and-reach test, handgrip strength test, squat jump (SJ), countermovement vertical jump without (CMJ) and with arm-swing, and a 30-s Bosco test. Eccentric utilization ratio (EUR) was calculated as the ratio CMJ to SJ. In adult players, there were significant differences between wings and the other positions with regard to anthropometric and body composition parameters (body mass, -17.9% to -13.2%; height, -5.3% to -4.3%; and fat-free mass, -13.7% to -9.9%) and anaerobic power assessed by WAnT (peak power, -20.5% to -15.2%; and mean power, -20% to -14.8%); however, these characteristics did not differ significantly in adolescents, in which the only statistically significant difference was found between goalkeepers and the other positions in EUR (+8.1%). Therefore, the differences in physical and physiological characteristics between playing positions are age-dependent. As adult players in this study were taken from players competing in the top Greek league, findings could serve as a base for talent identification and development for future studies. Moreover, knowledge about positional differences might enhance the ability to make tailored position-specific training programs among adult and adolescent players in the future.

Synthesis of [14α, 15α-3H]-17α-cyanomethyl-17β-hydroxyestra-4.9-diene-3-one - a specifically tritium labelled gestagen

International Nuclear Information System (INIS)

Roemer, J.; Wagner, H.

1978-05-01

Synthesis of [14α, 15α- 3 H 2 ]-17α-cyanomethyl-17β-hydroxyestra-4.9-diene-3-one from quantitativly tritiated [14α, 15α- 3 H 2 ]-3-methoxyestra-1,3,5(10),8-tetraene-17β-ol is described. The determination of the radiochemical purity and chemical yield was carried out by thin-layer chromatography. Preparative thin-layer chromatography was used for purifying the final product. By-products formed in the course of synthesis could be detected by determining and comparing specific activities of the intermediate products. Radiolytic investigations revealed the instability of the tritium labelled dienone system. (author)

An Individualized, Perception-Based Protocol to Investigate Human Physiological Responses to Cooling

Science.gov (United States)

Coolbaugh, Crystal L.; Bush, Emily C.; Galenti, Elizabeth S.; Welch, E. Brian; Towse, Theodore F.

2018-01-01

Cold exposure, a known stimulant of the thermogenic effects of brown adipose tissue (BAT), is the most widely used method to study BAT physiology in adult humans. Recently, individualized cooling has been recommended to standardize the physiological cold stress applied across participants, but critical experimental details remain unclear. The purpose of this work was to develop a detailed methodology for an individualized, perception-based protocol to investigate human physiological responses to cooling. Participants were wrapped in two water-circulating blankets and fitted with skin temperature probes to estimate BAT activity and peripheral vasoconstriction. We created a thermoesthesia graphical user interface (tGUI) to continuously record the subject's perception of cooling and shivering status during the cooling protocol. The protocol began with a 15 min thermoneutral phase followed by a series of 10 min cooling phases and concluded when sustained shivering (>1 min duration) occurred. Researchers used perception of cooling feedback (tGUI ratings) to manually adjust and personalize the water temperature at each cooling phase. Blanket water temperatures were recorded continuously during the protocol. Twelve volunteers (ages: 26.2 ± 1.4 years; 25% female) completed a feasibility study to evaluate the proposed protocol. Water temperature, perception of cooling, and shivering varied considerably across participants in response to cooling. Mean clavicle skin temperature, a surrogate measure of BAT activity, decreased (−0.99°C, 95% CI: −1.7 to −0.25°C, P = 0.16) after the cooling protocol, but an increase in supraclavicular skin temperature was observed in 4 participants. A strong positive correlation was also found between thermoesthesia and peripheral vasoconstriction (ρ = 0.84, P < 0.001). The proposed individualized, perception-based protocol therefore has potential to investigate the physiological responses to cold stress applied across populations with

Physiological Assessment of Water Stress in Potato Using Spectral Information.

Science.gov (United States)

Romero, Angela P; Alarcón, Andrés; Valbuena, Raúl I; Galeano, Carlos H

2017-01-01

Water stress in potato ( Solanum tuberosum L.) causes considerable losses in yield, and therefore, potato is often considered to be a drought sensitive crop. Identification of water deficit tolerant potato genotypes is an adaptation strategy to mitigate the climatic changes that are occurring in the Cundiboyacense region in Colombia. Previous studies have evaluated potato plants under water stress conditions using physiological analyses. However, these methodologies require considerable amounts of time and plant material to perform these measurements. This study evaluated and compared the physiological and spectral traits between two genotypes, Diacol Capiro and Perla Negra under two drought levels (10 and 15 days without irrigation from flowering). Reflectance information was used to calculate indexes which were associated with the physiological behavior in plants. The results showed that spectral information was correlated (ρ < 0.0001) with physiological variables such as foliar area (FA), total water content (H 2 Ot), relative growth rate of potato tubers (RGTtub), leaf area ratio (LAR), and foliar area index (AFI). In general, there was a higher concentration of chlorophyll under drought treatments. In addition, Perla Negra under water deficit treatments did not show significant differences in its physiological variables. Therefore, it could be considered a drought tolerant genotype because its physiological performance was not affected under water stress conditions. However, yield was affected in both genotypes after being subject to 15 days of drought. The results suggested that reflectance indexes are a useful and affordable approach for potato phenotyping to select parent and segregant populations in breeding programs.

The trilayer approach of teaching physiology, pathophysiology, and pharmacology concepts in a first-year pharmacy course: the TLAT model.

Science.gov (United States)

Islam, Mohammed A; Sabnis, Gauri; Farris, Fred

2017-09-01

This paper describes the development, implementation, and students' perceptions of a new trilayer approach of teaching (TLAT). The TLAT model involved blending lecture, in-class group activities, and out-of-class assignments on selected content areas and was implemented initially in a first-year integrated pharmacy course. Course contents were either delivered by traditional lectures or by the TLAT. A survey instrument was distributed by SurveyMonkey to determine students' perceptions of the TLAT model. Descriptive statistics were used for data analysis. Students' performance in a total of 225 examination and quiz questions was analyzed to evaluate whether the TLAT model improved students' learning. Students' ( n = 98) performance scores for TLAT-based and lecture-based questions were 83.3 ± 10.2 and 79.5 ± 14.0, respectively ( P Physiological Society.

Annual congress of the South African Society of Pathologists

International Nuclear Information System (INIS)

1981-01-01

The joint annual congress of the South African Society of Pathologists, International Academy of Pathology, South African Association of Clinical Biochemists and the Southern African Microbiology Society, was held from 13 to 15 July 1981 in Bloemfontein. This congress covered facets of clinical biochemistry, anatomical pathology, virology, microbiology, immunology and molecular biology

Role of glia in volume transmission in the CNS

Czech Academy of Sciences Publication Activity Database

Syková, Eva

2007-01-01

Roč. 191, č. 658 (2007), s. 16-16 ISSN 1748-1708. [The Physiological Society and The Federation of European Physiological Societies. 11.09.07-14.09.07, Bratislava] R&D Projects: GA MŠk(CZ) LC554 Institutional research plan: CEZ:AV0Z50390512 Keywords : extracellular space Subject RIV: FH - Neurology

14 CFR 120.15 - Refusal to submit to a drug or alcohol test by a Part 65 certificate holder.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Refusal to submit to a drug or alcohol test...: CERTIFICATION AND OPERATIONS DRUG AND ALCOHOL TESTING PROGRAM Individuals Certificated Under Parts 61, 63, and 65 § 120.15 Refusal to submit to a drug or alcohol test by a Part 65 certificate holder. (a) This...

Physiological indicators of pathologic video game use in adolescence.

Science.gov (United States)

Coyne, Sarah M; Dyer, W Justin; Densley, Rebecca; Money, Nathan M; Day, Randal D; Harper, James M

2015-03-01

Pathologic video game use (PVGU) has been associated with a host of negative psychological, physical, and social outcomes during adolescence; however, little research has examined physiological predictors of such use. The purpose of the study was to examine physiological predictors of the development of PVGU across adolescence. The article involves a 1-year longitudinal study across midadolescence. Participants were 374 adolescents and their parents from a large metropolitan area in the Northwest United States. PVGU was assessed via questionnaire, as were a number of control variables. A number of physiological indicators including respiratory sinus arrhythmia (RSA) and galvanic skin conductance (indices of parasympathetic and sympathetic nervous system activity, respectively) were measured during baseline, a cognitively stimulating task (Rubik's cube), and a family problem-solving task. Less RSA withdrawal to a cognitively simulating task was related to greater pathologic video game symptoms, but less RSA withdrawal to a family problem-solving task was associated with the presence of pathologic video game symptoms (p video game symptoms (p < .01). These findings suggest that adolescents who do not find cognitive tasks stimulating physiologically have a greater severity of PVGU. Additionally, adolescents who show physiological signs of stress in a family task were more likely to have PVGU symptoms and only girls have more severe PVGU levels. This study is the first to show that physiological indicators predict PVGU over time in adolescence and has important implications regarding the prevention and treatment of PVGU in adolescence. Copyright © 2015 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved.

April 2014 Arizona thoracic society notes

Directory of Open Access Journals (Sweden)

Robbins RA

2014-04-01

Full Text Available No abstract available. Article truncated at 150 words. The April 2014 Arizona Thoracic Society meeting was held on Wednesday, 4/23/2014 at Scottsdale Shea Hospital beginning at 6:30 PM. There were 15 in attendance representing the pulmonary, critical care, sleep, pathology and radiology communities. It was announced that there will be a wine tasting with the California, New Mexico and Colorado Thoracic Societies at the American Thoracic Society International Meeting. The tasting will be led by Peter Wagner and is scheduled for the Cobalt Room in the Hilton San Diego Bayfront on Tuesday, May 20, from 4-8 PM. Guideline development was again discussed. The consensus was to await publication of the IDSA Cocci Guidelines and respond appropriately. George Parides, Arizona Chapter Representative, gave a presentation on Hill Day. Representatives of the Arizona, New Mexico and Washington Thoracic Societies met with their Congressional delegations, including Rep. David Schweikert, to discuss the Cigar Bill, NIH funding, and the Medicare Sustainable Growth ...

Physiological arousal deficits in addicted gamers differ based on preferred game genre.

Science.gov (United States)

Metcalf, Olivia; Pammer, Kristen

2014-01-01

There has been significant discussion surrounding the psychopathology of excessive gaming and whether it constitutes an addiction. The current study investigated physiological and subjective levels of arousal in gamers of two genres and the relationship between sensation seeking and gaming addiction. Heart rate (HR), blood pressure (BP) and skin conductance were recorded at baseline, during gaming for 15 min and after gaming in 30 massively multiplayer online role-playing game (MMORPG) and 30 first-person shooter (FPS) male gamers. Gamers were identified as addicted using the Addiction-Engagement Questionnaire. Sensation seeking was measured using the Arnett Inventory of Sensation Seeking. Addicted MMORPG gamers (n=16) displayed significant decreases in cardiovascular activity during gaming compared to baseline and showed significant increases after gaming. Addicted FPS gamers (n=13) had significant increases in BP during gaming which decreased significantly after gaming. In comparison, non-addicted MMORPG gamers (n=14) had significant decreases in HR during gaming, whereas BP in non-addicted MMORPG and FPS gamers (n=17) increased during gaming and after gaming. There were no significant relationships between sensation seeking and addiction. There are physiological arousal deficits in addicted gamers, and these patterns differ according to the genre of game played. Copyright © 2013 S. Karger AG, Basel.

Physiological adaptation to recurrent social stress of extraversion.

Science.gov (United States)

Lu, Wei; Wang, Zhenhong

2017-02-01

The present studies examined the influence of extraversion on physiological reactivity, recovery, and physiological habituation-sensitization to repeated social stressors. In Study 1, subjective and physiological data were collected from 97 college students who were categorized as high (n = 51) and low (n = 46) on extraversion (NEO-FFI) across five laboratory stages: baseline, stress 1, poststress 1, stress 2, and poststress 2. Results indicated high extraversion (HE) participants exhibited relative lesser heart rate (HR) reactivity and respiratory sinus arrhythmia (RSA) withdrawals to, and more complete HR and RSA recovery after the first social stress, and also exhibited relative lesser HR reactivity to the second social stress. When repeatedly exposed to a social stressor, HE participants showed pronounced systolic blood pressure (SBP) adaptation, low extraversion (LE) participants displayed diastolic blood pressure (DBP) sensitization. In Study 2, data were collected from another 78 participants (HE: n = 40, LE: n = 38) across the same laboratory stages with speech performance videotaped. After controlling for the speech styles, Study 2 found the same HR response and SBP/DBP adaptation pattern across extraversion groups to social stress as Study 1 but not RSA reactivity. These findings suggest extraverts exhibit more adaptive physiological reactivity to recurrent social stressors, which thus might benefit their health. © 2016 Society for Psychophysiological Research.

Perspectives of Physiology as a Discipline from Senior-Level Millennial-Generation Students

Science.gov (United States)

Steury, Michael D.; Poteracki, James M.; Kelly, Kevin L.; Wehrwein, Erica A.

2015-01-01

In the last several decades, there has been a shift in the mindset of research structure from classical "systems or integrative biology" to more molecular focused "-omics" study. A recent topic of debate in physiological societies has been whether or not the "-omic" revolution has delivered in its promises in both…

Quality of Graphite Target for Biological/Biomedical/Environmental Applications of 14C-Accelerator Mass Spectrometry

Science.gov (United States)

2010-01-01

Catalytic graphitization for 14C-accelerator mass spectrometry (14C-AMS) produced various forms of elemental carbon. Our high-throughput Zn reduction method (C/Fe = 1:5, 500 °C, 3 h) produced the AMS target of graphite-coated iron powder (GCIP), a mix of nongraphitic carbon and Fe3C. Crystallinity of the AMS targets of GCIP (nongraphitic carbon) was increased to turbostratic carbon by raising the C/Fe ratio from 1:5 to 1:1 and the graphitization temperature from 500 to 585 °C. The AMS target of GCIP containing turbostratic carbon had a large isotopic fractionation and a low AMS ion current. The AMS target of GCIP containing turbostratic carbon also yielded less accurate/precise 14C-AMS measurements because of the lower graphitization yield and lower thermal conductivity that were caused by the higher C/Fe ratio of 1:1. On the other hand, the AMS target of GCIP containing nongraphitic carbon had higher graphitization yield and better thermal conductivity over the AMS target of GCIP containing turbostratic carbon due to optimal surface area provided by the iron powder. Finally, graphitization yield and thermal conductivity were stronger determinants (over graphite crystallinity) for accurate/precise/high-throughput biological, biomedical, and environmental14C-AMS applications such as absorption, distribution, metabolism, elimination (ADME), and physiologically based pharmacokinetics (PBPK) of nutrients, drugs, phytochemicals, and environmental chemicals. PMID:20163100

α/β-hydrolase domain containing protein 15 (ABHD15--an adipogenic protein protecting from apoptosis.

Directory of Open Access Journals (Sweden)

Evelyn Walenta

Full Text Available Our knowledge about adipocyte metabolism and development is steadily growing, yet many players are still undefined. Here, we show that α/β-hydrolase domain containing protein 15 (Abhd15 is a direct and functional target gene of peroxisome proliferator-activated receptor gamma (PPARγ, the master regulator of adipogenesis. In line, Abhd15 is mainly expressed in brown and white adipose tissue and strongly upregulated during adipogenesis in various murine and human cell lines. Stable knockdown of Abhd15 in 3T3-L1 cells evokes a striking differentiation defect, as evidenced by low lipid accumulation and decreased expression of adipocyte marker genes. In preconfluent cells, knockdown of Abhd15 leads to impaired proliferation, which is caused by apoptosis, as we see an increased SubG1 peak, caspase 3/7 activity, and BAX protein expression as well as a reduction in anti-apoptotic BCL-2 protein. Furthermore, apoptosis-inducing amounts of palmitic acid evoke a massive increase of Abhd15 expression, proposing an apoptosis-protecting role for ABHD15. On the other hand, in mature adipocytes physiological (i.e. non-apoptotic concentrations of palmitic acid down-regulate Abhd15 expression. Accordingly, we found that the expression of Abhd15 in adipose tissue is reduced in physiological situations with high free fatty acid levels, like high-fat diet, fasting, and aging as well as in genetically obese mice. Collectively, our results position ABHD15 as an essential component in the development of adipocytes as well as in apoptosis, thereby connecting two substantial factors in the regulation of adipocyte number and size. Together with its intricate regulation by free fatty acids, ABHD15 might be an intriguing new target in obesity and diabetes research.

Physiological evaluation of free-ranging moose (Alces alces immobilized with etorphine-xylazine-acepromazine in Northern Sweden

Directory of Open Access Journals (Sweden)

Evans Alina L

2012-12-01

Full Text Available Abstract Background Evaluation of physiology during capture and anesthesia of free-ranging wildlife is useful for determining the effect that capture methods have on both ecological research results and animal welfare. This study evaluates capture and anesthesia of moose (Alces alces with etorphine-xylazine-acepromazine in Northern Sweden. Methods Fifteen adult moose aged 3–15 years were darted from a helicopter with a combination of 3.37 mg etorphine, 75 mg xylazine, and 15 mg acepromazine. Paired arterial blood samples were collected 15 minutes apart with the first sample at 15–23 minutes after darting and were analyzed immediately with an i-STAT®1 Portable Clinical Analyzer. Results All animals developed hypoxemia (PaO2 2 5.5-8 kPa. All moose were acidemic (ph2, 14 moose had mild hypercapnia (PaCO2 6-8 kPa and two had marked hypercapnia (PaCO2>8 kPa. Pulse, respiratory rate, pH and HCO3 increased significantly over time from darting whereas lactate decreased. Conclusions The hypoxemia found in this study is a strong indication for investigating alternative drug doses or combinations or treatment with supplemental oxygen.

Starting physiology: bioelectrogenesis.

Science.gov (United States)

Baptista, Vander

2015-12-01

From a Cartesian perspective of rational analysis, the electric potential difference across the cell membrane is one of the fundamental concepts for the study of physiology. Unfortunately, undergraduate students often struggle to understand the genesis of this energy gradient, which makes the teaching activity a hard task for the instructor. The topic of bioelectrogenesis encompasses multidisciplinary concepts, involves several mechanisms, and is a dynamic process, i.e., it never turns off during the lifetime of the cell. Therefore, to improve the transmission and acquisition of knowledge in this field, I present an alternative didactic model. The design of the model assumes that it is possible to build, in a series of sequential steps, an assembly of proteins within the membrane of an isolated cell in a simulated electrophysiology experiment. Initially, no proteins are inserted in the membrane and the cell is at a baseline energy state; the extracellular and intracellular fluids are at thermodynamic equilibrium. Students are guided through a sequence of four steps that add key membrane transport proteins to the model cell. The model is simple at the start and becomes progressively more complex, finally producing transmembrane chemical and electrical gradients. I believe that this didactic approach helps instructors with a more efficient tool for the teaching of the mechanisms of resting membrane potential while helping students avoid common difficulties that may be encountered when learning this topic. Copyright © 2015 The American Physiological Society.

Approaches to modeling the development of physiological stress responsivity.

Science.gov (United States)

Hinnant, J Benjamin; Philbrook, Lauren E; Erath, Stephen A; El-Sheikh, Mona

2018-05-01

Influential biopsychosocial theories have proposed that some developmental periods in the lifespan are potential pivot points or opportunities for recalibration of stress response systems. To date, however, there have been few longitudinal studies of physiological stress responsivity and no studies comparing change in physiological stress responsivity across developmental periods. Our goals were to (a) address conceptual and methodological issues in studying the development of physiological stress responsivity within and between individuals, and (b) provide an exemplar for evaluating development of responsivity to stress in the parasympathetic nervous system, comparing respiratory sinus arrhythmia (RSA) responsivity from middle to late childhood with middle to late adolescence. We propose the use of latent growth modeling of stress responsivity that includes time-varying covariates to account for conceptual and methodological issues in the measurement of physiological stress responsivity. Such models allow researchers to address key aspects of developmental sensitivity including within-individual variability, mean level change over time, and between-individual variability over time. In an empirical example, we found significant between-individual variability over time in RSA responsivity to stress during middle to late childhood but not during middle to late adolescence, suggesting that childhood may be a period of greater developmental sensitivity at the between-individual level. © 2017 Society for Psychophysiological Research.

Adding Value to a Graduate Physiology Seminar by Focusing on Public Communication Skills

Science.gov (United States)

LaRocca, Thomas J.; Justice, Jamie N.; Seals, Douglas R.; Martens, Christopher R.

2016-01-01

A major goal of graduate education is the development of students as "stewards of the discipline," scholars who can create and preserve knowledge and responsibly translate it through writing, teaching, and practical applications. These qualities are consistent with the American Physiological Society's list of professional skills for…

Relations between Anthropometric Characteristics and Motor Abilities of 14 – 15U Female Swimmers on 50m Result for each Technique

Directory of Open Access Journals (Sweden)

Goran Dimitrić

2016-10-01

Full Text Available In aim of correlation between antropometric characteristics, motor abilities and results of swimming 50m in all swimming techniques, a group of 22 swimmers (girls of Serbian national team, aged 14-15, underwent some anthropometric measurements as well as some motor abilities. Observed longitudinal dimensions were: body height, body mass, arm span and torax circumference and observed motor abilities were: body strength (arms, legs, stomach and flexibility (trunk and arms. Regression analisys showed that arm span corellated with 50m butterfly and free style score as well as strenght of body and legs corellated with 50m backstroke and free style score. Other measures didn΄t corelatted significantly on this sample. Study results confirms importance of arm span and some segments of body strenhgt of swimmers (girls for successful swimm on 50m in butterfly, backstroke and freestyle techniques in the age 14-15 years.

Use of an iPad App to simulate pressure-volume loops and cardiovascular physiology.

Science.gov (United States)

Leisman, Staci; Burkhoff, Daniel

2017-09-01

The purpose of this laboratory exercise is to model the changes in preload, afterload, and contractility on a simulated pressure-volume loop and to correlate those findings with common measurements of clinical cardiovascular physiology. Once students have modeled these changes on a healthy heart, the students are asked to look at a simulated case of cardiogenic shock. Effects on preload, contractility, and afterload are explored, as well as the hemodynamic effects of a number of student-suggested treatment strategies. Copyright © 2017 the American Physiological Society.

The 14N(p, γ)15O reaction studied at low and high beam energy

International Nuclear Information System (INIS)

Marta, Michele

2012-01-01

The Bethe-Weizsaecker cycle consists of a set of nuclear reactions that convert hydrogen into helium and release energy in the stars. It determines the luminosity of low-metal stars at their turn-off from the main-sequence in the Hertzsprung-Russel diagram, so its rate enters the calculation of the globular clusters' age, an independent lower limit on the age of the universe. The cycle contributes less than 1% to our Sun's luminosity, but it produces neutrinos that can in principle be measured on Earth in underground experiments and bring direct information of the physical conditions in the solar core, provided that the nuclear reaction rate is known with sufficient precision. The 14 N(p,γ) 15 O reaction is the slowest reaction of the Bethe-Weizsaecker cycle and establishes its rate. Its cross section is the sum of the contributions by capture to different excited levels and to the ground state in 15 O. Recent experiments studied the region of the resonance at E p = 278 keV. Only one modern data set from an experiment performed in 1987 is available for the high-energy domain. Both energy ranges are needed to constrain the fit of the excitation function in the R-matrix framework and to obtain a reliable extrapolated S-factor at the very low astrophysical energies. The present research work studied the 14 N(p,γ) 15 O reaction in the LUNA (Laboratory for Underground Nuclear Astrophysics) underground facility at three proton energies 0.36, 0.38, 0.40MeV, and in Dresden in the energy range E p = 0.6 - 2MeV. In both cases, an intense proton beam was sent on solid titanium nitride sputtered targets, and the prompt photons emitted from the reaction were detected with germanium detectors. At LUNA, a composite germanium detector was used. This enabled a measurement with dramatically reduced summing corrections with respect to previous studies. The cross sections for capture to the ground state and to the excited states at 5181, 6172, and 6792 keV in 15 O have been

14 CFR 187.15 - Payment of fees.

Science.gov (United States)

2010-01-01

... REGULATIONS FEES § 187.15 Payment of fees. (a) The fees of this part are payable to the Federal Aviation Administration by check, money order, wire transfers, draft, payable in U.S. currency and drawn on a U.S. bank, or by credit card payable in U.S. currency, prior to the provision of any service under this part. (b...

Proceedings, sixth international symposium : moisture and creep effects on paper, board and containers: Madison, Wisconsin, USA, 14-15 July 2009

Science.gov (United States)

John M. Considine; Sally A. Ralph

2011-01-01

The USDA Forest Products Laboratory sponsored the 6th International Symposium: Moisture and Creep Effects on Paper, Board and Containers at the Monona Terrace Convention Center, Madison, WI, USA on 14-15 July 2009. Attendees heard 20 technical presentations; presenters were from seven different countries and three continents. Session topics included Corrugated...

Membership in cooperative societies

Directory of Open Access Journals (Sweden)

Eba Gaminde Egia

2017-12-01

Full Text Available In this work we will analyze the practical application of one of the cooperative principles, «voluntary and free membership», referring to the entering of members in cooperative societies. We will first explain the meaning of this principle, and then bring up its normative regulation, with special emphasis on those aspects in which our autonomic laws differ, and ending with a brief reference to the economic aspect and the different ways to make contributions and their consequences.Received: 31 May 2017Accepted: 14 October 2017Published online: 22 December 2017

Using whiteboards to support college students' learning of complex physiological concepts.

Science.gov (United States)

Inouye, Caron Y; Bae, Christine L; Hayes, Kathryn N

2017-09-01

Research underscores the importance of retrieval-based practice and application of knowledge for meaningful learning. However, the didactic lecture format continues to persist in traditional university physiology courses. A strategy called whiteboarding, where students use handheld dry erase boards and work in small groups to actively retrieve, discuss, and apply concepts presented in the lecture, has the potential to address challenges associated with actively engaging students in science courses for greater learning. The purpose of this study was to empirically examine the potential benefits of whiteboarding for increasing students' understanding of animal physiology concepts. Student performance on physiology questions assessing concepts taught using lecture only vs. concepts taught using lecture and whiteboarding were compared within the term that whiteboarding was used, as well as across whiteboard and lecture-only terms taught by the same instructor. Results showed that when whiteboarding was incorporated in the course, student performance on items that assessed concepts corresponding to the whiteboarding activities were significantly higher compared with performance on items that assessed concepts taught through lecture only. These patterns in student performance were found within and across terms. Taken together, findings point to whiteboarding as an effective tool that can be integrated in traditional lecture courses to promote students' understanding of physiology. Copyright © 2017 the American Physiological Society.

Pain: metaphor, body, and culture in Anglo-American societies between the eighteenth and twentieth centuries.

Science.gov (United States)

Bourke, Joanna

2014-10-02

This article explores the relationship between metaphorical languages, body, and culture, and suggests that such an analysis can reveal a great deal about the meaning and experience of pain in Anglo-American societies between the eighteenth and twentieth centuries. It uses concepts within embodied cognition to speculate on how historians can write a history of sensation. Bodies are actively engaged in the linguistic processes and social interactions that constitute painful sensations. Language is engaged in a dialogue with physiological bodies and social environments. And culture collaborates in the creation of physiological bodies and metaphorical systems.

Metabolism-oriented amino acid requirement determination by means of the catabolic rates of 14C- and 15N-labelled lysine under maintenance

International Nuclear Information System (INIS)

Simon, O.; Bergner, H.; Adam, K.

1977-01-01

Male Wistar rats (of 60 g live weight) allotted in 10 groups were fed diets with gradually increasing lysine levels ranging from 1.4 to 7.4 g lysine/16 g N. Feed intake was restricted so much that the experimental animals did not change their live weights during the last 3 days of the 8-day experimental period. On the 7the experimental day, 4 animals of each group were injected, i. p. 14 C-L-lysine, the 14 CO 2 -excretion being subsequently measured over a period of 2 hours. On the next day, 6 animals of each group were applied an i. p. injection of 15 N-L-lysine, the urine being collected over the following 24-hour period to measure the 15 N-frequency. Applying both labelling methods, an increased catabolisation of the amino acid was observed after the metabolically necessary lysine requirement had been covered. The methods are very sensitive and revealed, under the experimental conditions chosen, a lysine requirement coverage of about 3 g lysine/16 g N. The possibility of using also 15 N-labelled compounds in the metabolism-oriented amino acid requirement determination is likely to facilitate the transfer of the methodology to farm animals would thus allow to study the amino acid requirement of man. The metabolism-oriented amino acid requirement determination will likewise allow to estimate exact amino acid requirement data under conditions that cannot be rated on the basis of productive yields. (author)

PHYSIOLOGIC PATTERNS OF SLEEP ON EEG, MASKING OF EPILEPTIFORM ACTIVITY

Directory of Open Access Journals (Sweden)

L. Yu. Glukhova

2013-01-01

Full Text Available Physiologic patterns of sleep on EEG can sometimes be similar to epileptiform activity and even to the EEG pattern of epileptic seizures, but they have no connection to epilepsy and their incorrect interpretation may lead to overdiagnosis of epilepsy. These sleep patterns include vertex transients, K-complexes, hypnagogic hypersynchrony, 14 and 6 Hz positive bursts, wicket-potentials, etc. The main distinctive features of acute physiological phenomena of sleep unlike epileptiform activity are stereotyped, monomorphic morphology of waves, which frequently has rhythmic, arcuate pattern, often with change of lateralization, mainly dominated in the first stages of sleep (N1-N2, with their reduction in the deeper stages and transition to delta sleep (N3. The correct interpretation of physiological sharp-wave phenomena of sleep on EEG requires considerable training and experience of the physician. Our review includes a variety of physiological sleep patterns, which can mimic epileptiform activity on EEG, their criteria of diagnostic with demonstration of own illustrations of EEG.

55th Annual Canadian Society for Molecular Biosciences Conference on Epigenetics and Genomic Stability. Whistler, British Columbia, Canada, 14–18 March 2012.

Science.gov (United States)

Nelson, Christopher J; Ausió, Juan

2012-06-01

The 55th Annual Canadian Society for Molecular Biosciences Conference on Epigenetics and Genomic Stability in Whistler, Canada, 14-18 March 2012, brought together 31 speakers from different nationalities. The organizing committee, led by Jim Davie (Chair) at the University of Manitoba (Manitoba, Canada), consisted of several established researchers in the fields of chromatin and epigenetics from across Canada. The meeting was centered on the contribution of epigenetics to gene expression, DNA damage and repair, and the role of environmental factors. A few interesting talks on replication added some insightful information on the controversial issue of histone post-translational modifications as genuine epigenetic marks that are inherited through cell division.

Plasma concentrations, behavioural and physiological effects following intravenous and intramuscular detomidine in horses.

Science.gov (United States)

Mama, K R; Grimsrud, K; Snell, T; Stanley, S

2009-11-01

Detomidine hydrochloride is used to provide sedation, muscle relaxation and analgesia in horses, but a lack of information pertaining to plasma concentration has limited the ability to correlate drug concentration with effect. To build on previous information and assess detomidine for i.v. and i.m. use in horses by simultaneously assessing plasma drug concentrations, physiological parameters and behavioural characteristics. Systemic effects would be seen following i.m. and i.v. detomidine administration and these effects would be positively correlated with plasma drug concentrations. Behavioural (e.g. head position) and physiological (e.g. heart rate) responses were recorded at fixed time points from 4 min to 24 h after i.m. or i.v. detomidine (30 microg/kg bwt) administration to 8 horses. Route of administration was assigned using a balanced crossover design. Blood was sampled at predetermined time points from 0.5 min to 48 h post administration for subsequent detomidine concentration measurements using liquid chromatography-mass spectrometry. Data were summarised as mean +/- s.d. for subsequent analysis of variance for repeated measures. Plasma detomidine concentration peaked earlier (1.5 min vs. 1.5 h) and was significantly higher (105.4 +/- 71.6 ng/ml vs. 6.9 +/- 1.4 ng/ml) after i.v. vs. i.m. administration. Physiological and behavioural changes were of a greater magnitude and observed at earlier time points for i.v. vs. i.m. groups. For example, head position decreased from an average of 116 cm in both groups to a low value 35 +/- 23 cm from the ground 10 min following i.v. detomidine and to 64 +/- 24 cm 60 min after i.m. detomidine. Changes in heart rate followed a similar pattern; low value of 17 beats/min 10 min after i.v. administration and 29 beats/min 30 min after i.m. administration. Plasma drug concentration and measured effects were correlated positively and varied with route of administration following a single dose of detomidine. Results support a

15 CFR 14.28 - Period of availability of funds.

Science.gov (United States)

2010-01-01

... REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, OTHER NON-PROFIT, AND COMMERCIAL ORGANIZATIONS Post-Award Requirements Financial and Program Management § 14.28 Period of...

The ins and outs of breath holding: simple demonstrations of complex respiratory physiology.

Science.gov (United States)

Skow, Rachel J; Day, Trevor A; Fuller, Jonathan E; Bruce, Christina D; Steinback, Craig D

2015-09-01

The physiology of breath holding is complex, and voluntary breath-hold duration is affected by many factors, including practice, psychology, respiratory chemoreflexes, and lung stretch. In this activity, we outline a number of simple laboratory activities or classroom demonstrations that illustrate the complexity of the integrative physiology behind breath-hold duration. These activities require minimal equipment and are easily adapted to small-group demonstrations or a larger-group inquiry format where students can design a protocol and collect and analyze data from their classmates. Specifically, breath-hold duration is measured during a number of maneuvers, including after end expiration, end inspiration, voluntary prior hyperventilation, and inspired hyperoxia. Further activities illustrate the potential contribution of chemoreflexes through rebreathing and repeated rebreathing after a maximum breath hold. The outcome measures resulting from each intervention are easily visualized and plotted and can comprise a comprehensive data set to illustrate and discuss complex and integrated cardiorespiratory physiology. Copyright © 2015 The American Physiological Society.

Validation of the Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition Recommendations for Caloric Provision to Critically Ill Obese Patients: A Pilot Study.

Science.gov (United States)

Mogensen, Kris M; Andrew, Benjamin Y; Corona, Jasmine C; Robinson, Malcolm K

2016-07-01

The Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (ASPEN) recommend that obese, critically ill patients receive 11-14 kcal/kg/d using actual body weight (ABW) or 22-25 kcal/kg/d using ideal body weight (IBW), because feeding these patients 50%-70% maintenance needs while administering high protein may improve outcomes. It is unknown whether these equations achieve this target when validated against indirect calorimetry, perform equally across all degrees of obesity, or compare well with other equations. Measured resting energy expenditure (MREE) was determined in obese (body mass index [BMI] ≥30 kg/m(2)), critically ill patients. Resting energy expenditure was predicted (PREE) using several equations: 12.5 kcal/kg ABW (ASPEN-Actual BW), 23.5 kcal/kg IBW (ASPEN-Ideal BW), Harris-Benedict (adjusted-weight and 1.5 stress-factor), and Ireton-Jones for obesity. Correlation of PREE to 65% MREE, predictive accuracy, precision, bias, and large error incidence were calculated. All equations were significantly correlated with 65% MREE but had poor predictive accuracy, had excessive large error incidence, were imprecise, and were biased in the entire cohort (N = 31). In the obesity cohort (n = 20, BMI 30-50 kg/m(2)), ASPEN-Actual BW had acceptable predictive accuracy and large error incidence, was unbiased, and was nearly precise. In super obesity (n = 11, BMI >50 kg/m(2)), ASPEN-Ideal BW had acceptable predictive accuracy and large error incidence and was precise and unbiased. SCCM/ASPEN-recommended body weight equations are reasonable predictors of 65% MREE depending on the equation and degree of obesity. Assuming that feeding 65% MREE is appropriate, this study suggests that patients with a BMI 30-50 kg/m(2) should receive 11-14 kcal/kg/d using ABW and those with a BMI >50 kg/m(2) should receive 22-25 kcal/kg/d using IBW. © 2015 American Society for Parenteral and Enteral Nutrition.

Report and Abstracts of the 14th Meeting of IIM, the Interuniversity Institute of Myology, - Assisi (Italy, October 12-15, 2017

Directory of Open Access Journals (Sweden)

Diego Gabellini

2017-12-01

Full Text Available The 14th Meeting of the Interuniversity Institute of Myology (IIM, October 12-15, 2017 - Assisi, Italy gathered together researchers from Italy, European and North-American countries to discuss recent results on muscle research. The program showcased keynote lectures from world-renowned international speakers presenting advances in muscle physiology, bioengineering, metabolism and therapeutics. Based on selection from submitted abstracts, participants presented their novel, unpublished results in seven oral communication and two poster sessions. Particular emphasis was devoted to young trainees. For example, trainees where directly involved in organizing a scientific session and three round tables tailored to the interests of their peers. The meeting attracted a broad audience from Italy, various European countries and from North America. It offered a unique opportunity to all researchers involved in the field of muscle biology to exchange ideas and foster scientific collaborations to better understand the causative mechanisms of muscular diseases and to improve the design of more efficient therapeutic strategies. The friendly and inclusive atmosphere promoted the active participation of junior scientists to exciting discussions, which allowed to identify emerging areas of myology research and encouraged scientific cross-fertilization to facilitate exchanges between different laboratories in different countries. The meeting was a success and this community will continue to deliver major contributions to our understanding of muscle development and function, the pathogenesis of muscle diseases and the development of novel therapeutic approaches. Here, we report abstracts of the meeting discussing recent results of basic, translational and early clinical studies confirming that the field of Myology is strong and articulated, maturing toward clinical development for the treatment of muscle diseases.

How do the Institutes on Teaching and Learning (ITLs) nurture the members of the Physiology Educators Community of Practice (PECOP)?

Science.gov (United States)

Goodman, Barbara E

2017-09-01

Do you teach physiology? Do you use best practices when you teach physiology? Have you ever thought about conducting educational research? Do you need collaborators to help with ideas for educational research or to expand your research populations? The American Physiological Society (APS) Teaching Section has developed a biennial Institute on Teaching and Learning (ITL) through the APS Conference Program to address these issues. The first institute was held in June 2014, and the second institute was held in June 2016. A Physiology Education Community of Practice (PECOP) was created to help connect the institute participants and other physiology educators and to share evidence-based teaching in physiology at all education levels. The 2018 APS ITL will be the next meeting to learn best practices, to share ideas with colleagues, and to find collaborators in improving the teaching of physiology for students. The meeting will include workshops modeling best practices, plenary talks about hot new issues in physiology and science education, and poster sessions and informal meals to discuss interests with colleagues. Even if one's primary responsibility is bench research or administration, the training from the institute will improve efficiency and effectiveness when teaching. The two prior ITLs (2014 and 2016) were highly evaluated by educators of both undergraduate and professional students who spent a week together emphasizing improvement in their teaching. This paper reports the outcomes of the 2016 ITL and encourages participation in the upcoming ITL in Madison, WI, June 18-22, 2018. Watch the APS Conference site for more information about the 2018 ITL (http://www.the-aps.org/mm/Conferences/APS-Conferences). Copyright © 2017 the American Physiological Society.

15N/14N variations in Cretaceous Atlantic sedimentary sequences: implication for past changes in marine nitrogen biogeochemistry

Science.gov (United States)

Rau, G.H.; Arthur, M.A.; Dean, W.E.

1987-01-01

At two locations in the Atlantic Ocean (DSDP Sites 367 and 530) early to middle Cretaceous organic-carbon-rich beds ("black shales") were found to have significantly lower ??15N values (lower 15N/14N ratios) than adjacent organic-carbon-poor beds (white limestones or green claystones). While these lithologies are of marine origin, the black strata in particular have ??15N values that are significantly lower than those previously found in the marine sediment record and most contemporary marine nitrogen pools. In contrast, black, organic-carbon-rich beds at a third site (DSDP Site 603) contain predominantly terrestrial organic matter and have C- and N-isotopic compositions similar to organic matter of modern terrestrial origin. The recurring 15N depletion in the marine-derived Cretaceous sequences prove that the nitrogen they contain is the end result of an episodic and atypical biogeochemistry. Existing isotopic and other data indicate that the low 15N relative abundance is the consequence of pelagic rather than post-depositional processes. Reduced ocean circulation, increased denitrification, and, hence, reduced euphotic zone nitrate availability may have led to Cretaceous phytoplankton assemblages that were periodically dominated by N2-fixing blue-green algae, a possible source of this sediment 15N-depletion. Lack of parallel isotopic shifts in Cretaceous terrestrially-derived nitrogen (Site 603) argues that the above change in nitrogen cycling during this period did not extend beyond the marine environment. ?? 1987.

Past and present of adolescence in society: the 'teen brain' debate in perspective.

Science.gov (United States)

Feixa, Carles

2011-08-01

Understood as the stage in individual life comprised between physiological puberty (a "natural" condition) and the recognition of the adult status (a "cultural" construction), adolescence has been envisaged as a universal condition, a stage in human development to be found in all societies and historical moments. Nevertheless, anthropological founding's across space and times depict a more complex panorama. The large variety of situations can be grouped into five big models of adolescence, which correspond to different types of society: "puber" from the primitive stateless societies; "ephebe" from ancient states; "boy and girl" from pre-industrial rural societies; "teenager" from the first industrialisation process and "youngsters" from modern post-industrial societies. In order to describe the features of these five models of youth, this article presents a series of ethnographical examples to illustrate the enormous plasticity of adolescence in past and present. This perspective is to be considered as the psycho-social and cultural environment for adolescent brain development, that will be discussed in depth along in this special issue. Copyright © 2011 Elsevier Ltd. All rights reserved.

Abortion in a just society.

Science.gov (United States)

Hunt, M E

1993-01-01

A female Catholic theologian imagines a just society that does not judge women who decide to undergo an abortion. The Church, practitioners, and the courts must trust that women do make person-enhancing choices about the quality of life. In the last 15 years most progress in securing a woman's right to abortion has been limited to white, well-educated, and middle or upper middle class women. A just society would consider reproductive options a human right. Abortion providers are examples of a move to a just society; they are committed to women's well-being. There are some facts that make one pessimistic about achieving abortion in a just society. The US Supreme Court plans to review important decisions establishing abortion as a civil right. Further, some men insist on suing women who want to make their own reproductive decisions--an anti-choice tactic to wear away women's right to reproductive choice. Bombings of abortion clinics and harassment campaigns by anti-choice groups are common. These behaviors strain pro-choice proponents emotionally, psychically, and spiritually. Their tactics often lead to theologians practicing self-censorship because they fear backlash. Abortion providers also do this. Further, the reaction to AIDS is that sex is bad. Anti-abortion groups use AIDS to further their campaigns, claiming that AIDS is a punishment for sex. Strategies working towards abortion in a just society should be education and persuasion of policymakers and citizens about women's right to choose, since they are the ones most affected by abortion. Moreover, only women can secure their rights to abortion. In a just society, every health maintenance organization, insurance company, and group practice would consider abortion a normal service. A just society provides for the survival needs of the most marginalized.

Non-destructive testing of proteins in single seeds using the 14N(d,p)15N and 14N(d,∝)12C reactions

International Nuclear Information System (INIS)

Moreno B, E.

1986-01-01

A non-destructive nuclear technique aimed for the analysis of proteins in single seeds using the 14 N(d,p) 15 N and 14 N(d,∝) 12 C reactions is implemented. This work was performed at the ININ's Tandem Van der Graaff facility, using a 6 MeV deuteron beam and a surface barrier solid state detector with its associated electronics for the pulse height analysis of the charged particles backscattered from the samples. Well defined populations of five varieties of wheat, and four of corn were used as samples in order to optimize the experimental conditions for the analysis, these results were compared with those obtained using an analytical chemical method (Kjeldahl). The linear regression coefficient (''r'') obtained from the results of these two methods was: r = 0.9 in the case of wheat, and r = 0.7 in the case of corn, which we consider adequate figures for using the non-destructive nuclear technique as an aid or support in agricultural seed protein improvement programs. In adequate geometrical conditions the analysis per seed can take a few seconds, and the exposure to the germ can be as low as ≅1 Rad. (author)

Synthesis of a polycyclic aromatic hydrocarbon marked with carbon-14: (b, d e f) dibenzo-chrysene {sup 14}C-7,14; Synthese d'un hydrocarbure aromatique polycyclique marque au carbone 14: le dibenzo (b, d e f) chrysene {sup 14}C-7,14

Energy Technology Data Exchange (ETDEWEB)

Chatelain, G [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1965-07-01

(b, d e f) dibenzo-chrysene C-7,14 has been synthesized from radioactive carbon dioxide and the organic magnesium compound derived from 1,5 dibromo naphthalene. The product has been purified by a very precise series of fractionated chromatographs on alumina having a chromatographic activity. This has necessitated the development of a special technique. (author) [French] Le dibenzo (b, d e f) chrysene 14C-7,14 a ete synthetise au depart de gaz carbonique radioactif et de bis-organomagnesien derive du dibromo-1,5 naphtalene. Le produit a ete purifie par une serie de chromatographies fractionnees sur alumine d'activite chromatographique tres precise. Ceci a fait l'objet d'une mise au point de technique. (auteur)

Official Program and Abstracts of the 15. Meeting of the Latin-American Association of Biology and Nuclear Medicine Societies (ALASBIMN 97); Iberoamerican Congress of Nuclear Medicine

International Nuclear Information System (INIS)

1997-01-01

This issue contains 117 abstracts of lectures and poster sessions of the 15th Meeting of the Latin-American Association of Biology and Nuclear Medicine Societies (ALASBIMN 97) and Iberoamerican Congress of Nuclear Medicine, held in Lima, Peru, from 26 to 30 October 1997. The key subjects addressed are nuclear medicine and diagnostic techniques on brain, liver, lungs, heart, osteo-articular, cardiology, oncology, endocrinology, radiopharmaceuticals, medical physics, SPECT and their applications in diagnostic medicine. (APC)

A new empirical formula for 14-15 MeV neutron-induced (n, p) reaction cross sections

International Nuclear Information System (INIS)

Tel, E; Sarer, B; Okuducu, S; Aydin, A; Tanir, G

2003-01-01

In this study, we have suggested a new empirical formula to reproduce the cross sections of the (n, p) reactions at 14-15 MeV for the neutron incident energy. This formula obtained using the asymmetry parameters represents a modification to the original formula of Levkovskii. The resulting modified formulae yielded cross sections, representing smaller χ 2 deviations from experimental values, and values much closer to unity as compared with those calculated using Levkovskii's original formula. The results obtained have been discussed and compared with the existing formulae, and found to be well in agreement, when used to correlate the available experimental σ(n, p) data of different nuclei

Nasal Physiology

Science.gov (United States)

... Caregivers Contact ARS HOME ANATOMY Nasal Anatomy Sinus Anatomy Nasal Physiology Nasal Endoscopy Skull Base Anatomy Virtual Anatomy Disclosure ... Patient Education About this Website Font Size + - Home > ANATOMY > Nasal Physiology Nasal Anatomy Sinus Anatomy Nasal Physiology Nasal Endoscopy ...

Clinical and molecular characterization of two patients with overlapping de novo microdeletions in 2p14-p15 and mild mental retardation

DEFF Research Database (Denmark)

Wohlleber, Eva; Kirchhoff, Eva Maria; Zink, Alexander M

2011-01-01

Here, we present two patients with overlapping de novo microdeletions in chromosome 2p14-p15, mild mental retardation concerning especially language development, as well as mild dysmorphic features. Patient 1 also presented with generalized seizures, sensorineural hearing loss, and relative...

Deep water ventilation in the northwestern North Pacific during the last deglaciation and the early Holocene (15-5 cal. kyr B.P.) based on AMS 14C dating

International Nuclear Information System (INIS)

Minoshima, Kayo; Kawahata, Hodaka; Irino, Tomohisa; Ikehara, Ken; Aoki, Kaori; Uchida, Masao; Yoneda, Minoru; Shibata, Yasuyuki

2007-01-01

The difference between benthic and planktonic foraminifera radiocarbon (B-P 14 C) age differences in core PC6 (40 o 23.89' N, 143 o 29.87' E) retrieved from the northwestern North Pacific provide a clue to the reconstruction of deep water circulation during the last deglaciation and the early Holocene (15-5 cal. kyr B.P.). The observed B-P 14 C age differences ranged from 1030 to 1630 years, which are comparable to the present-day apparent ventilation age. It suggested that the ventilation generally remained similar during 15-5 cal. kyr B.P. However, B-P 14 C age difference slightly reduced at 14.6 cal. kyr B.P., indicating that the higher ventilation temporality could have occurred in the northwestern North Pacific (∼2200 m water depth)

Using paper presentation breaks during didactic lectures improves learning of physiology in undergraduate students.

Science.gov (United States)

Ghorbani, Ahmad; Ghazvini, Kiarash

2016-03-01

Many studies have emphasized the incorporation of active learning into classrooms to reinforce didactic lectures for physiology courses. This work aimed to determine if presenting classic papers during didactic lectures improves the learning of physiology among undergraduate students. Twenty-two students of health information technology were randomly divided into the following two groups: 1) didactic lecture only (control group) and 2) didactic lecture plus paper presentation breaks (DLPP group). In the control group, main topics of gastrointestinal and endocrine physiology were taught using only the didactic lecture technique. In the DLPP group, some topics were presented by the didactic lecture method (similar to the control group) and some topics were taught by the DLPP technique (first, concepts were covered briefly in a didactic format and then reinforced with presentation of a related classic paper). The combination of didactic lecture and paper breaks significantly improved learning so that students in the DLPP group showed higher scores on related topics compared with those in the control group (P physiology. Copyright © 2016 The American Physiological Society.

Brazilian actions to promote physiology learning and teaching in secondary and high schools.

Science.gov (United States)

Mello-Carpes, Pâmela B; Granjeiro, Érica Maria; Montrezor, Luís Henrique; Rocha, Maria José Alves

2016-06-01

Members of the Education Committee of the Brazilian Society of Physiology have developed multiple outreach models to improve the appreciation of science and physiology at the precollege level. The members of this committee act in concert with important Brazilian governmental strategies to promote training of undergraduate students in the teaching environment of secondary and high schools. One of these governmental strategies, the Programa Institucional de Bolsas de Iniciação à Docência, a Brazilian public policy of teaching enhancement implemented by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) since 2007, represents a well-articulated public policy that can promote the partnership between University and Schools (7). Furthermore, the Program "Novos Talentos" (New Talents)/CAPES/Ministry of Education is another government initiative to bring together university and high-level technical training with the reality of Brazilian schools. Linked to the New Talents Program, in partnership with the British Council/Newton Fund, CAPES recently promoted the visit of some university professors that coordinate New Talents projects to formal and informal educational science spaces in the United Kingdom (Science, Technology, Engineering, and Mathematics, Brazil-United Kingdom International Cooperation Program) to qualify the actions developed in this area in Brazil, and one of us had the opportunity to participate with this. Copyright © 2016 The American Physiological Society.

Hearing and loud music exposure in 14-15 years old adolescents

Directory of Open Access Journals (Sweden)

Mario R Serra

2014-01-01

The participants consisted in 172 14-15 years old adolescents from a technical high school. Conventional and extended high frequency audiometry, transient evoked otoacoustic emissions and questionnaire on recreational habits were administered. Hearing threshold levels (HTLs were classified as: normal (Group 1, slightly shifted (Group 2, and significantly shifted (Group 3. The musical general exposure (MGE, from participation in recreational musical activities, was categorized in low, moderate, and high exposure. The results revealed an increase of HTL in Group 2 compared with Group 1 (P < 0.01, in Group 3 compared with Group 2 (P < 0.05 only in extended high frequency range, in Group 3 compared with Group 1 (P < 0.01. Besides, a decrease in mean global amplitude, reproducibility and in frequencies amplitude in Group 2 compared with Group 1 (P < 0.05 and in Group 3 compared with Group 1 (P < 0.05. A significant difference (P < 0.05 was found in Group 1′s HTL between low and high exposure, showing higher HTL in high exposure. The sound immission measured in nightclubs (107.8-112.2 dBA and PMPs (82.9-104.6 dBA revealed sound levels risky for hearing health according to exposure times. It demonstrates the need to implement preventive and hearing health promoting actions in adolescents.

The Physiological Foundations of the Wealth of Nations

DEFF Research Database (Denmark)

Dalgaard, Carl-Johan Lars; Strulik, Holger

Evidence from economics, anthropology and biology testifies to a fundamental trade-off between the number of offspring (quantity) and amount of nutrition per child (quality). This leads to a theory of pre-industrial growth where body size as well as population size is endogenous. But when...... productive quality investments are undertaken the historical constancy of income per capita seems puzzling. Why didn't episodes of rising income instigate a virtuous circle of rising body size and productivity? To address this question we propose that societies are subject to a "physiological check...

proceedings of the 11. Annual meeting of the Federation of Societies on Experimental Biology

International Nuclear Information System (INIS)

1996-01-01

The proceedings of the 11. Annual meeting of the Federation of Societies on Experimental Biology contains 1850 abstracts, which include the following topics: neuroscience and behaviour; biophysics; pharmacology; comparative physiology; nervous regulation; endocrinology; nefrology; vascular biology; toxicity; molecular biophysics; radiobiology and others. Among these, 169 abstracts have been indexed separately for the INIS database

System Theory and Physiological Processes.

Science.gov (United States)

Jones, R W

1963-05-03

Engineers and physiologists working together in experimental and theoretical studies predict that the application of system analysis to biological processes will increase understanding of these processes and broaden the base of system theory. Richard W. Jones, professor of electrical engineering at Northwestern University, Evanston, Illinois, and John S. Gray, professor of physiology at Northwestern's Medical School, discuss these developments. Their articles are adapted from addresses delivered in Chicago in November 1962 at the 15th Annual Conference on Engineering in Medicine and Biology.

Excellent Survival and Good Outcomes at 15 Years Using the Press-Fit Condylar Sigma Total Knee Arthroplasty.

Science.gov (United States)

Oliver, William M; Arthur, Calum H C; Wood, Alexander M; Clayton, Robert A E; Brenkel, Ivan J; Walmsley, Philip

2018-03-27

We report 15-year survival, clinical, and radiographic follow-up data for the Press-Fit Condylar Sigma total knee arthroplasty. Between October 1998 and October 1999, 235 consecutive TKAs were performed in 203 patients. Patients were reviewed at a specialist nurse-led clinic before surgery and at 5, 8-10, and 15 years postoperatively. Clinical outcomes, including Knee Society Score, were recorded prospectively at each clinic visit, and radiographs were obtained. Of our initial cohort, 99 patients (118 knees) were alive at 15 years, and 31 patients (34 knees) were lost to follow-up. Thirteen knees (5.5%) were revised; 5 (2.1%) for infection, 7 (3%) for instability, and 1 (0.4%) for aseptic loosening. Cumulative survival with the end point of revision for any reason was 92.3% at 15 years and with revision for aseptic failure as the end point was 94.4%. The mean Knee Society Score knee score was 77.4 (33-99) at 15 years, compared with 31.7 (2-62) preoperatively. Of 71 surviving knees for which X-rays were available, 12 (16.9%) had radiolucent lines and 1 (1.4%) demonstrated clear radiographic evidence of loosening. The Press-Fit Condylar Sigma total knee arthroplasty represents a durable, effective option for patients undergoing knee arthroplasty, with excellent survival and good clinical and radiographic outcomes at 15 years. Copyright © 2018 Elsevier Inc. All rights reserved.

Materials of yearly scientific assembly of Polish Chemical Society, Lublin 1995

International Nuclear Information System (INIS)

1995-01-01

Scientific conference accompanied the yearly assembly of Polish Chemical Society has bee held in 1995 in Lublin. The general review on scientific progress of the most important field of chemistry in Poland have been presented. The conference has been divided into 16 plenary sessions and 3 microsymposia. The sessions topics as follows: S-1 - physical chemistry; S-2 - physicochemistry of the surface; S-3 - catalysis; S-4 - chemical technology; S-5 - inorganic chemistry; S-6 - coordination chemistry; S-7 -crystallochemistry; S-8 - electrochemistry; S-9 - organic chemistry; S-10 -chemistry of polymers; S-11 - chemistry in medicine; S-12 - chemistry and technology of solid state materials; S-13 - young scientists forum; S-14 -didactics in chemistry; S-15 - theoretical chemistry; S-16 - environmental protection. Also the 3 microsymposia have been organized. It was: M-1 -chemistry of heteroorganic compounds; M-2 chromatography; M-3 - plasma chemistry

Integrating multimedia instructional design principles with complex physiological concepts in reproductive science

Science.gov (United States)

Oki, Angela Christine

2011-12-01

This dissertation examines the effect of digital multimedia presentations as a method to teach complex concepts in reproductive physiology. The digital presentations developed for this research consisted of two-dimensional (2-D) and three-dimensional (3-D) animations, scriptmessaging and narration. The topics were "Mammalian Ovarian Follicular Dynamics", "The Physiology of the Menstrual Cycle", and "The Physiology of Parturition". In all four experiments, participants were randomly assigned to treatment groups and learning was measured with multiple-choice tests. Experiment 1 determined if type of animation impacted learning about the physiology of the menstrual cycle. The treatments were: 3-D and 2-D animation (n = 110), 2-D animation only (n = 109) and no animation (n = 108). All three presentations were 14 minutes. No treatment effects were found (p > 0.05), indicating that student performance was not influenced by animation type. In experiment 2, the influence of added narrative explanations about the physiology of parturition was determined. The delivery time for the two treatments was 14 minutes (n = 164) and 24 minutes (n = 157), respectively. There were no differences between treatment groups (p > 0.05), indicating that concise explanations were as effective as elaborate explanations. Experiment 3 determined the influence of a digital presentation on knowledge retention of follicular dynamics over the course of a semester. Treatments were: a digital presentation (n = 23) or a classroom lecture captured on video (n = 23). Students completed three tests during the semester. Students in the multimedia group outperformed students in the video lecture group on all three tests (p read a booklet (n = 57) or viewed a multimedia presentation (n = 65) about parturition. Content was identical in each group. Patients in the multimedia group outperformed patients in the booklet group (p < 0.05). This set of four experiments indicates that digital multimedia

Observing and understanding arterial and venous circulation differences in a physiology laboratory activity.

Science.gov (United States)

Altermann, Caroline; Gonçalves, Rithiele; Lara, Marcus Vinícius S; Neves, Ben-Hur S; Mello-Carpes, Pâmela B

2015-12-01

The purpose of the present article is to describe three simple practical experiments that aim to observe and discuss the anatomic and physiological functions and differences between arteries and veins as well as the alterations observed in skin blood flow in different situations. For this activity, students were divided in small groups. In each group, a volunteer is recruited for each experiment. The experiments only require a sphygmomanometer, rubber bands, and a clock and allow students to develop a hypothesis to explain the different responses to the interruption of arterial and venous blood flow. At the end, students prepare a short report, and the results are discussed. This activity allows students to perceive the presence of physiology in their daily lives and helps them to understand the concepts related to the cardiovascular system and hemodynamics. Copyright © 2015 The American Physiological Society.

A constructivist approach to e-text design for use in undergraduate physiology courses.

Science.gov (United States)

Rhodes, Ashley E; Rozell, Timothy G

2015-09-01

Electronic textbooks, or e-texts, will have an increasingly important role in college science courses within the next few years due to the rising costs of traditional texts and the increasing availability of software allowing instructors to create their own e-text. However, few guidelines exist in the literature to aid instructors in the development and design specifically of e-texts using sound learning theories; this is especially true for undergraduate physiology e-texts. In this article, we describe why constructivism is a very important educational theory for e-text design and how it may be applied in e-text development by instructors. We also provide examples of two undergraduate physiology e-texts that were designed in accordance with this educational theory but for learners of quite different backgrounds and prior knowledge levels. Copyright © 2015 The American Physiological Society.

Using ecology to inform physiology studies: implications of high population density in the laboratory.

Science.gov (United States)

Newman, Amy E M; Edmunds, Nicholas B; Ferraro, Shannon; Heffell, Quentin; Merritt, Gillian M; Pakkala, Jesse J; Schilling, Cory R; Schorno, Sarah

2015-03-15

Conspecific density is widely recognized as an important ecological factor across the animal kingdom; however, the physiological impacts are less thoroughly described. In fact, population density is rarely mentioned as a factor in physiological studies on captive animals and, when it is infrequently addressed, the animals used are reared and housed at densities far above those in nature, making the translation of results from the laboratory to natural systems difficult. We survey the literature to highlight this important ecophysiological gap and bring attention to the possibility that conspecific density prior to experimentation may be a critical factor influencing results. Across three taxa: mammals, birds, and fish, we present evidence from ecology that density influences glucocorticoid levels, immune function, and body condition with the intention of stimulating discussion and increasing consideration of population density in physiology studies. We conclude with several directives to improve the applicability of insights gained in the laboratory to organisms in the natural environment. Copyright © 2015 the American Physiological Society.

Proceedings of the 14. Congress of the Maria Sklodowska-Curie Polish Radiation Society

International Nuclear Information System (INIS)

Lankoff, A.; Wojcik, A.

2007-01-01

Held every three years Congress of the Polish Radiation Research Society presents the latest achievements in the radiation research. In 2007 participants presented 9 plenary lectures, 38 section lectures and 61 posters. Communications and posters covered four disciplines: (a) radiobiology and radiotherapy, (b) radiation chemistry and photochemistry, (c) non-ionizing radiation, (d) radioprotection and the environmental radiation

Physiology for engineers applying engineering methods to physiological systems

CERN Document Server

Chappell, Michael

2016-01-01

This book provides an introduction to qualitative and quantitative aspects of human physiology. It looks at biological and physiological processes and phenomena, including a selection of mathematical models, showing how physiological problems can be mathematically formulated and studied. It also illustrates how a wide range of engineering and physics topics, including electronics, fluid dynamics, solid mechanics and control theory can be used to describe and understand physiological processes and systems. Throughout the text there are introductions to measuring and quantifying physiological processes using both signal and imaging technologies. Physiology for Engineers describes the basic structure and models of cellular systems, the structure and function of the cardiovascular system, the electrical and mechanical activity of the heart and provides an overview of the structure and function of the respiratory and nervous systems. It also includes an introduction to the basic concepts and applications of reacti...

Lower Urinary Tract Urological Abnormalities and Urodynamic Findings of Physiological Urinary Incontinence Versus Non-mono Symptomatic Nocturnal Enuresis in Children.

Science.gov (United States)

Naseri, Mitra

2014-03-01

Although 98% of children attain daytime bladder control by three years of age, urinary incontinence is regarded physiological up to the fifth year of life. This study aimed to assess whether lower urinary tract urological abnormalities and abnormal urodynamic findings are infrequent in children with physiological urinary incontinence in contrast to those with non-monosymptomatic nocturnal enuresis (NMNE). During a three-year period (2007-2009), 66 neurologically normal children including 51 children (34 girls, 17 boys) older than five years of age with NMNE and intermittent daytime incontinence, and 15 children with physiological urinary incontinence (eight girls and seven boys) aged four to five years of age without any known urological abnormalities were enrolled in the study. Patients with neurologic deficits or known urological anomalies were excluded from the study. Kidney-bladder ultrasonography, voiding cystourethrography (VCUG), and urodynamic studies were performed to evaluate the anatomy of urinary tract and bladder function. Urinary tract infection was found in 23 (34.8%) children, 17 (33.3%) and 6 (40%) patients with NMNE and physiological urinary incontinence, respectively. Out of 48 patients who underwent VCUG, vesicoureteral reflux (VUR) was found in seven and eight children younger and older than five years of age, respectively. Abnormal urodynamic findings were reported in 5 (62.5%) of eight children younger than five-year-old, and 14 (63.6%) of 22 patients older than 5-year-old. VUR might be more frequent in children with physiological urinary incontinence than the normal population, and might be as common as NMNE with intermittent daytime incontinence.

Acute Physiologic Stress and Subsequent Anxiety Among Family Members of ICU Patients.

Science.gov (United States)

Beesley, Sarah J; Hopkins, Ramona O; Holt-Lunstad, Julianne; Wilson, Emily L; Butler, Jorie; Kuttler, Kathryn G; Orme, James; Brown, Samuel M; Hirshberg, Eliotte L

2018-02-01

The ICU is a complex and stressful environment and is associated with significant psychologic morbidity for patients and their families. We sought to determine whether salivary cortisol, a physiologic measure of acute stress, was associated with subsequent psychologic distress among family members of ICU patients. This is a prospective, observational study of family members of adult ICU patients. Adult medical and surgical ICU in a tertiary care center. Family members of ICU patients. Participants provided five salivary cortisol samples over 24 hours at the time of the patient ICU admission. The primary measure of cortisol was the area under the curve from ground; the secondary measure was the cortisol awakening response. Outcomes were obtained during a 3-month follow-up telephone call. The primary outcome was anxiety, measured by the Hospital Anxiety and Depression Scale-Anxiety. Secondary outcomes included depression and posttraumatic stress disorder. Among 100 participants, 92 completed follow-up. Twenty-nine participants (32%) reported symptoms of anxiety at 3 months, 15 participants (16%) reported depression symptoms, and 14 participants (15%) reported posttraumatic stress symptoms. In our primary analysis, cortisol level as measured by area under the curve from ground was not significantly associated with anxiety (odds ratio, 0.94; p = 0.70). In our secondary analysis, however, cortisol awakening response was significantly associated with anxiety (odds ratio, 1.08; p = 0.02). Roughly one third of family members experience anxiety after an ICU admission for their loved one, and many family members also experience depression and posttraumatic stress. Cortisol awakening response is associated with anxiety in family members of ICU patients 3 months following the ICU admission. Physiologic measurements of stress among ICU family members may help identify individuals at particular risk of adverse psychologic outcomes.

Single event effects induced by 15.14 MeV/u sup 1 sup 3 sup 6 Xe ions

CERN Document Server

Hou Ming Dong; LiuJie; Wang Zhi Guang; Jin Yun Fan; Zhu Zhi Yong; Zhen Hong Lou; Liu Chang Long; Chen Xiao Xi; Wei Xin Guo; Zhang Li; Fan You Cheng; Zhu Zhou Rong; Zhang Yiting

2002-01-01

Single event effects induced by 15.14 MeV/u sup 1 sup 3 sup 6 Xe ions in different batches of 32k x 8 bits static random access memory are studied. The incident angle dependences of the cross sections for single event upset and single event latch up are presented. The SEE cross sections are plotted versus energy loss instead of linear energy transfer value in sensitive region. The depth of sensitive volume and thickness of 'dead' layer above the sensitive volume are estimated

Cerebral cross-perfusion and the Circle of Willis: does physiology trump anatomy?

Directory of Open Access Journals (Sweden)

Musicki K

2017-07-01

Full Text Available Korana Musicki,1 Katherine Victoria Hurst,1,2 Zoltán Molnár,3 Elizabeth Hardy,4 Ashok Handa,1,2 1Department of Vascular Surgery, John Radcliffe Hospital, 2Nuffield Department of Surgical Sciences, 3Department of Physiology, Anatomy and Genetics, University of Oxford, 4Vascular Studies Unit, John Radcliffe Hospital, Oxford, UK Introduction: Cerebral cross-perfusion is essential for ipsilateral brain viability during unilateral insult. Aortic arch and great vessel procedures depend on its function for safe practice, unless adjuncts like shunts are used. This paper assesses the contribution of cerebrovascular anatomy against physiology in determining requisite hemispheric perfusion during carotid endarterectomy (CEA.Materials and methods: A review of shunting requirements for CEAs under locoregional anesthesia (LA at the John Radcliffe Hospital during 1999–2013 was performed. A PubMed search for “Circle of Willis” was screened for all original articles defining cerebrovascular anatomy by postmortem or angiography.Results: Over 14 years, 1137 CEAs were performed under cervical plexus block; during this period, the departmental standard of practice evolved from exclusively general anesthesia to predominantly LA. CEAs performed under LA during the early phase (1999–2003 had a shunt rate of 15.1%, compared to 20% as predicted by stump pressures alone. However, shunting decreased as higher perioperative systolic pressures were routinely practiced; shunt rates were 8.0% during the intermediate (2004–2007 and 6.4% during the later (2008–2013 phase. By comparison, 25 articles characterizing 6414 brains report an intact circle of Willis in 33–35% of people, with a complete hemi-circle anteriorly (77% seen more commonly than posteriorly (42%, and 11–16% deficient in both hemi-circles with no cross-flow.Conclusion: Cerebral cross-perfusion is fundamental for safe CEA. Anatomy of the circle of Willis alone does not itself determine adequacy

Reminiscing about Jan Evangelista Purkinje: a pioneer of modern experimental physiology.

Science.gov (United States)

Cavero, Icilio; Guillon, Jean-Michel; Holzgrefe, Henry H

2017-12-01

This article reminisces about the life and key scientific achievements of Jan Evangelista Purkinje (1787-1869), a versatile 19th century Czech pioneer of modern experimental physiology. In 1804, after completing senior high school, Purkinje joined the Piarist monk order, but, after a 3-yr novitiate, he gave up the religious calling "to deal more freely with science." In 1818, he earned a Medical Doctor degree from Prague University by defending a dissertation on intraocular phenomena observed in oneself. In 1823, Purkinje became a Physiology and Pathology professor at the Prussian Medical University in Breslau, where he innovated the traditional teaching methods of physiology. Purkinje's contributions to physiology were manifold: accurate descriptions of various visual phenomena (e.g., Purkinje-Sanson images, Purkinje phenomenon), discovery of the terminal network of the cardiac conduction system (Purkinje fibers), identification of cerebellar neuronal bodies (Purkinje cells), formulation of the vertigo law (Purkinje's law), discovery of criteria to classify human fingerprints, etc. In 1850, Purkinje accepted and held until his death the Physiology chair at Prague Medical Faculty. During this period, he succeeded in introducing the Czech idiom (in addition to long-established German and Latin) as a Medical Faculty teaching language. Additionally, as a zealous Czech patriot, he actively contributed to the naissance and consolidation of a national Czech identity conscience. Purkinje was a trend-setting scientist who, throughout his career, worked to pave the way for the renovation of physiology from a speculative discipline, ancilla of anatomy, into a factual, autonomous science committed to the discovery of mechanisms governing in-life functions. Copyright © 2017 the American Physiological Society.

Incorporation of 15N and 14C into amino acids of bacterial and protozoal protein in the rumen of the cow on urea-rich feed

Directory of Open Access Journals (Sweden)

Eeva-Liisa Syväoja

1979-01-01

Full Text Available The utilization of the non-protein nitrogen and carbon of feed by rumen microorganisms for the synthesis of protein was studied by administering [U-14C] sucrose and 15NH4Cl to a cow on urea-rich, low-protein feed. By studying the labelling of the protozoa and bacteria and the amino acids isolated from them at intervals up to 48 hours afterwards, it was found that the bacteria synthesized amino acids from nonprotein nitrogen much more rapidly and effectively than the protozoa. Also the labelling of the carbon in the amino acids of the bacteria was more rapid than in the protozoa. In both protozoa and bacteria there was intracellular storage of [14C] sucrose. Of the bacterial amino acids the most vigorous 14C labelling was found in Glu, Arg, Lys, Val and Ala and the weakest labelling in Gly, His and Ser. Of the protozoal amino acids Ala, Asp, Glu, Leu and Lys had the highest labelling and Pro, Gly, His and Phe the lowest. In the bacterial protein the labelling of Pro and Arg was ten times that of the corresponding protozoal amino acids, and Asp, Ser and Ala four times. After the 15NH4Cl dose the half-life of 15N in the rumen fluid was estimated to be 3.3 h. Labelled ammonium nitrogen was about 11 —15 % of the bacterial nitrogen and 2—3 % of the protozoal nitrogen after 1 h. Of the protozoal amino acids Ala, Glu, Val, Asp and Met had the most vigorous labelling, and of the bacterial amino acids Glu, Asp, Ser, He and Tyr. The slowest incorporation of ammonium nitrogen was into His, Pro, Arg and Gly in both bacteria and protozoa. The labelling of the bacterial amino acids was approximately 7—8 times more vigorous than that of the protozoal amino acids. The labelling of Ala was only 4 times, and that of Val, Met and Glu 5 times more vigorous than with protozoal protein. The pathway of histidine synthesis seemed to be restricted in both bacteria and protozoa and therefore may be a limiting factor in protein synthesis, particularly in cows fed

The Physiology undergraduate major in the University of Arizona College of Medicine: past, present, and future.

Science.gov (United States)

Henriksen, Erik J; Atwater, Anne E; Delamere, Nicholas A; Dantzler, William H

2011-06-01

The American Physiological Society (APS) and APS Council encourage the teaching of physiology at the undergraduate, graduate, and medical school levels to support the continued prominence of this area of science. One area identified by the APS Council that is of particular importance for the development of future physiologists (the "physiology pipeline") is the teaching of physiology and physiology-related topics at the undergraduate level. In this article, we describe the historical development and implementation of an undergraduate program offered through the Department of Physiology, a basic science department in the College of Medicine at the University of Arizona, culminating in a Bachelor of Science in Health Sciences degree with a major in Physiology. Moreover, we discuss the current Physiology curriculum offered at our institution and explain how this program prepares our students for successful entry into a variety of postbaccalaureate professional programs, including medical school and numerous other programs in health professions, and in graduate study in the Masters and Doctoral programs in biomedical sciences. Finally, we cover the considerable challenges that we have faced, and continue to face, in developing and sustaining a successful physiology undergraduate major in a college of medicine. We hope that the information provided on the Physiology major offered by the Department of Physiology in the College of Medicine at the University of Arizona will be helpful for individuals at other institutions who may be contemplating the development and implementation of an undergraduate program in Physiology.

Physiological response and productivity of safflower lines under water deficit and rehydration.

Science.gov (United States)

Bortolheiro, Fernanda P A P; Silva, Marcelo A

2017-01-01

Water deficit is one of the major stresses affecting plant growth and productivity worldwide. Plants induce various morphological, physiological, biochemical and molecular changes to adapt to the changing environment. Safflower (Carthamus tinctorius L.), a potential oil producer, is highly adaptable to various environmental conditions, such as lack of rainfall and temperatures. The objective of this work was to study the physiological and production characteristics of six safflower lines in response to water deficit followed by rehydration. The experiment was conducted in a protected environment and consisted of 30 days of water deficit followed by 18 days of rehydration. A differential response in terms of photosynthetic pigments, electrolyte leakage, water potential, relative water content, grain yield, oil content, oil yield and water use efficiency was observed in the six lines under water stress. Lines IMA 04, IMA 10, IMA 14 showed physiological characteristics of drought tolerance, with IMA 14 and IMA 16 being the most productive after water deficit. IMA 02 and IMA 21 lines displayed intermediate characteristics of drought tolerance. It was concluded that the lines responded differently to water deficit stress, showing considerable genetic variation and influence to the environment.

Physiological response and productivity of safflower lines under water deficit and rehydration

Directory of Open Access Journals (Sweden)

FERNANDA P.A.P. BORTOLHEIRO

2017-12-01

Full Text Available ABSTRACT Water deficit is one of the major stresses affecting plant growth and productivity worldwide. Plants induce various morphological, physiological, biochemical and molecular changes to adapt to the changing environment. Safflower (Carthamus tinctorius L., a potential oil producer, is highly adaptable to various environmental conditions, such as lack of rainfall and temperatures. The objective of this work was to study the physiological and production characteristics of six safflower lines in response to water deficit followed by rehydration. The experiment was conducted in a protected environment and consisted of 30 days of water deficit followed by 18 days of rehydration. A differential response in terms of photosynthetic pigments, electrolyte leakage, water potential, relative water content, grain yield, oil content, oil yield and water use efficiency was observed in the six lines under water stress. Lines IMA 04, IMA 10, IMA 14 showed physiological characteristics of drought tolerance, with IMA 14 and IMA 16 being the most productive after water deficit. IMA 02 and IMA 21 lines displayed intermediate characteristics of drought tolerance. It was concluded that the lines responded differently to water deficit stress, showing considerable genetic variation and influence to the environment.

Rice Physiology

Science.gov (United States)

P.A. Counce; Davidi R. Gealy; Shi-Jean Susana Sung

2002-01-01

Physiology occurs tn physical space through chemical reactions constrained by anatomy and morphology, yet guided by genetics. Physiology has been called the logic of life. Genes encode structural and fimcdonal proteins. These proteins are subsequently processed to produce enzymes that direct and govern the biomechanical processes involved in the physiology of the...

Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Δ12,14-prostaglandin J2

International Nuclear Information System (INIS)

Mishra, Nandita; Kar, Rekha; Singha, Prajjal K.; Venkatachalam, Manjeri A.; McEwen, Donald G.; Saikumar, Pothana

2010-01-01

Arachidonic acid derived endogenous electrophile 15d-PGJ2 has gained much attention in recent years due to its potent anti-proliferative and anti-inflammatory actions mediated through thiol modification of cysteine residues in its target proteins. Here, we show that 15d-PGJ2 at 1 μM concentration converts normal mitochondria into large elongated and interconnected mitochondria through direct binding to mitochondrial fission protein Drp1 and partial inhibition of its GTPase activity. Mitochondrial elongation induced by 15d-PGJ2 is accompanied by increased assembly of Drp1 into large oligomeric complexes through plausible intermolecular interactions. The role of decreased GTPase activity of Drp1 in the formation of large oligomeric complexes is evident when Drp1 is incubated with a non-cleavable GTP analog, GTPγS or by a mutation that inactivated GTPase activity of Drp1 (K38A). The mutation of cysteine residue (Cys644) in the GTPase effector domain, a reported target for modification by reactive electrophiles, to alanine mimicked K38A mutation induced Drp1 oligomerization and mitochondrial elongation, suggesting the importance of cysteine in GED to regulate the GTPase activity and mitochondrial morphology. Interestingly, treatment of K38A and C644A mutants with 15d-PGJ2 resulted in super oligomerization of both mutant Drp1s indicating that 15d-PGJ2 may further stabilize Drp1 oligomers formed by loss of GTPase activity through covalent modification of middle domain cysteine residues. The present study documents for the first time the regulation of a mitochondrial fission activity by a prostaglandin, which will provide clues for understanding the pathological and physiological consequences of accumulation of reactive electrophiles during oxidative stress, inflammation and degeneration.

Lansoprazole 15 mg once daily for 14 days is effective for treatment of frequent heartburn: results of 2 randomized, placebo-controlled, double-blind studies.

Science.gov (United States)

Kushner, Pamela R; Snoddy, Andrew M; Gilderman, Larry; Peura, David A

2009-07-01

To investigate the efficacy and safety of a 14-day treatment period with lansoprazole 15 mg for frequent heartburn in patients who are likely to select a nonprescription medication before consulting a prescriber. Adults with untreated frequent heartburn > or = 2 days a week over the past month were recruited for 2 identical multicenter, double-blind studies conducted with a 1-week screening and heartburn medication washout, a 1-week placebo run-in, a 2-week placebo-controlled treatment, and a 1-week placebo follow-up. After the washout and placebo run-in, subjects were randomly assigned to receive lansoprazole 15 mg or placebo once daily for 14 days in a double-blind fashion. Antacid tablets were permitted as rescue medication. Endpoints included percentage of 24-hour days without heartburn (primary), percentage of night-times without heartburn, and percentage of subjects without heartburn during day 1 of treatment (secondary endpoints). Data were collected daily via an interactive voice response system. In studies 1 and 2, 282 and 288 subjects, respectively, were randomly assigned to lansoprazole, and 282 in each study received placebo. The mean percentage of days without heartburn was greater among lansoprazole recipients compared with placebo recipients (P heartburn and no heartburn during day 1 of the 14-day treatment. Adverse events were infrequent and were similar for lansoprazole and placebo groups. During the 14-day treatment period in a population with frequent heartburn who were likely to select a medication without consulting a prescriber, lansoprazole 15 mg once daily showed rapid and sustained effectiveness throughout a 24-hour period and was well tolerated.

24 Annual meeting of the Spanish Nuclear Society, Valladolid 14-16 October 1998

International Nuclear Information System (INIS)

1998-01-01

The technical sessions of XXIV annual meeting of the Spanish Nuclear Society were: 1) Fusion 2) Engineering: calculation and simulation. 3) Economical, legal and social aspect. 4) Plant life extension 5) Operating experiences, refueling and operation support 6) Probabilistic safety 7) Radiological protection 8) Waste management 9)Maintenance 10) Nuclear Safety R and D. 11)Environmental aspects 12) Fuel 13) Quality

Repetitive Supra-Physiological Shear Stress Impairs Red Blood Cell Deformability and Induces Hemolysis.

Science.gov (United States)

Horobin, Jarod T; Sabapathy, Surendran; Simmonds, Michael J

2017-11-01

The supra-physiological shear stress that blood is exposed to while traversing mechanical circulatory assist devices affects the physical properties of red blood cells (RBCs), impairs RBC deformability, and may induce hemolysis. Previous studies exploring RBC damage following exposure to supra-physiological shear stress have employed durations exceeding clinical instrumentation, thus we explored changes in RBC deformability following exposure to shear stress below the reported "hemolytic threshold" using shear exposure durations per minute (i.e., duty-cycles) reflective of that employed by circulatory assist devices. Blood collected from 20 male donors, aged 18-38 years, was suspended in a viscous medium and exposed to an intermittent shear stress protocol of 1 s at 100 Pa, every 60 s for 60 duty-cycles. During the remaining 59 s/min, the cells were left at stasis until the subsequent duty-cycle commenced. At discrete time points (15/30/45/60 duty-cycles), an ektacytometer measured RBC deformability immediately after shear exposure at 100 Pa. Plasma-free hemoglobin, a measurement of hemolysis, was quantified via spectrophotometry. Supra-physiological shear stress impaired RBC properties, as indicated by: (1) decreased maximal elongation of RBCs at infinite shear stress following 15 duty-cycles (P supra-physiological shear stress protocol (100 Pa) following exposure to 1 duty-cycle (F (1.891, 32.15) = 12.21, P = 0.0001); and (3) increased plasma-free hemoglobin following 60 duty-cycles (P supra-physiological shear stress, impairs RBC deformability, with the extent of impairment exacerbated with each duty-cycle, and ultimately precipitates hemolysis. © 2017 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.

The evolution of honest communication: integrating social and physiological costs of ornamentation.

Science.gov (United States)

Tibbetts, Elizabeth A

2014-10-01

Much research on animal communication has addressed how costs such as social costs or physiological costs favor the accuracy of signals. Previous work has largely considered these costs separately, but we may be missing essential connections by studying costs in isolation. After all, social interactions produce rapid changes in hormone titers which can then affect individual behavior and physiology. As a result, social costs are likely to have widespread physiological consequences. Here, I present a new perspective on the factors that maintain honest signals by describing how the interplay between social costs and physiological costs may maintain an accurate link between an animal's abilities and ornament elaboration. I outline three specific mechanisms by which the interaction between social behavior and hormones could favor honest signals and present specific predictions for each of the three models. Then, I review how ornaments alter agonistic behavior, agonistic behavior influences hormones, and how these hormonal effects influence fitness. I also describe the few previous studies that have directly tested how ornaments influence hormones. Finally, opportunities for future work are discussed. Considering the interaction between social behavior and physiology may address some challenges associated with both social and physiological models of costs. Understanding the dynamic feedbacks between physiology and social costs has potential to transform our understanding of the stability of animals' communication systems. © The Author 2014. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

Physiological parameters

International Nuclear Information System (INIS)

Natera, E.S.

1998-01-01

The physiological characteristics of man depend on the intake, metabolism and excretion of stable elements from food, water, and air. The physiological behavior of natural radionuclides and radionuclides from nuclear weapons testing and from the utilization of nuclear energy is believed to follow the pattern of stable elements. Hence information on the normal physiological processes occurring in the human body plays an important role in the assessment of the radiation dose received by man. Two important physiological parameters needed for internal dose determination are the pulmonary function and the water balance. In the Coordinated Research Programme on the characterization of Asian population, five participants submitted data on these physiological characteristics - China, India, Japan, Philippines and Viet Nam. During the CRP, data on other pertinent characteristics such as physical and dietary were simultaneously being collected. Hence, the information on the physiological characteristics alone, coming from the five participants were not complete and are probably not sufficient to establish standard values for the Reference Asian Man. Nonetheless, the data collected is a valuable contribution to this research programme

ICPC 14: what is missing?

OpenAIRE

Santos, Ariovaldo dos; Londero, Paola R.

2017-01-01

ABSTRACT The purpose of this study is to raise questions about Technical Interpretation 14 (ICPC 14) from the Accounting Standards Committee with regards to the statutory characteristics of Brazilian cooperative societies. We do not aim to provide definitive solutions by exhausting all conceptual analyses and accounting alternatives involving the reclassification of member shares, or “quotas”, from net equity to liabilities, but rather to present some considerations with regards to points tha...

Densities and speeds of sound for binary mixtures of (1,3-dioxolane or 1,4-dioxane) with (2-methyl-1-propanol or 2-methyl-2-propanol) at the temperatures (298.15 and 313.15) K

International Nuclear Information System (INIS)

Villares, A.; Martin, S.; Haro, M.; Giner, B.; Artigas, H.

2004-01-01

This paper reports densities and speeds of sound for the binary mixtures of (1,3-dioxolane or 1,4-dioxane) with (2-methyl-1-propanol or 2-methyl-2-propanol) at the temperatures (298.15 and 313.15) K. Excess volumes and excess isentropic compressibility coefficients have been calculated from experimental data and fitted by means of a Redlich-Kister type equation. The ERAS model has been used to calculate the excess volumes of the four systems at both temperatures

Elite futsal refereeing: Activity profile and physiological demands

DEFF Research Database (Denmark)

Rebelo, António N.; Ascensão, António A.; Magalhães, José F.

2011-01-01

Rebelo, AN, Ascensão, AA, Magalhães, JF, Bischoff, R, Bendiksen, M, and Krustrup, P. Elite futsal refereeing: activity profile and physiological demands. J Strength Cond Res 24(X): 000-000, 2010-The purpose of this study was to determine the physiological demands and to establish the relationship...... between activity profile and endurance capacity of futsal referees. Eighteen elite futsal referees (33.0 ± 5.1 years, 173 ± 5 cm, and 73.2 ± 8.4 kg) were studied. Video filming (n = 18) and heart rate (HR) recordings were performed throughout games. Blood lactate (n = 14) was determined at rest and after....... Considering the data obtained in the present study, the use of match-specific intermittent fitness tests to evaluate futsal referees seems to be required....

Activity-Based Profiling of a Physiologic Aglycone Library Reveals Sugar Acceptor Promiscuity of Family 1 UDP-Glucosyltransferases from Grape1[W

Science.gov (United States)

Bönisch, Friedericke; Frotscher, Johanna; Stanitzek, Sarah; Rühl, Ernst; Wüst, Matthias; Bitz, Oliver; Schwab, Wilfried

2014-01-01

Monoterpenols serve various biological functions and accumulate in grape (Vitis vinifera), where a major fraction occurs as nonvolatile glycosides. We have screened the grape genome for sequences with similarity to terpene URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASES (UGTs) from Arabidopsis (Arabidopsis thaliana). A ripening-related expression pattern was shown for three candidates by spatial and temporal expression analyses in five grape cultivars. Transcript accumulation correlated with the production of monoterpenyl β-d-glucosides in grape exocarp during ripening and was low in vegetative tissue. Targeted functional screening of the recombinant UGTs for their biological substrates was performed by activity-based metabolite profiling (ABMP) employing a physiologic library of aglycones built from glycosides isolated from grape. This approach led to the identification of two UDP-glucose:monoterpenol β-d-glucosyltransferases. Whereas VvGT14a glucosylated geraniol, R,S-citronellol, and nerol with similar efficiency, the three allelic forms VvGT15a, VvGT15b, and VvGT15c preferred geraniol over nerol. Kinetic resolution of R,S-citronellol and R,S-linalool was shown for VvGT15a and VvGT14a, respectively. ABMP revealed geraniol as the major biological substrate but also disclosed that these UGTs may add to the production of further glycoconjugates in planta. ABMP of aglycone libraries provides a versatile tool to uncover novel biologically relevant substrates of small-molecule glycosyltransferases that often show broad sugar acceptor promiscuity. PMID:25073706

15-Deoxy-Delta-12,14-Prostaglandin J2 Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma

Directory of Open Access Journals (Sweden)

Diego S. Coutinho

2017-06-01

Full Text Available 15-deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2 has been described as an anti-inflammatory lipid mediator in several in vitro and in vivo studies, but its effect on allergic pulmonary inflammation remains elusive. The aim of this study was to investigate the therapeutic potential of 15d-PGJ2 based on distinct murine models of allergic asthma triggered by either ovalbumin (OVA or house dust mite extract (HDM. Characteristics of lung inflammation, airway hyper-reactivity (AHR, mucus exacerbation, and lung remodeling in sensitized A/J mice treated or not with 15d-PGJ2 were assessed. 15d-PGJ2 treatments were carried out systemically or topically given via subcutaneous injection or intranasal instillation, respectively. Analyses were carried out 24 h after the last allergen provocation. Irrespective of the route of administration, 15d-PGJ2 significantly inhibited the peribronchial accumulation of eosinophils and neutrophils, subepithelial fibrosis and also mucus exacerbation caused by either OVA or HDM challenge. The protective effect of 15d-PGJ2 occurred in parallel with inhibition of allergen-induced AHR and lung tissue production of pro-inflammatory cytokines, such as interleukin (IL-5, IL-13, IL-17, and TNF-α. Finally, 15d-PGJ2 was found effective in inhibiting NF-κB phosphorylation upon HDM challenge as measured by Western blotting. In conclusion, our findings suggest that 15d-PGJ2 can reduce crucial features of asthma, including AHR, lung inflammation, and remodeling in distinct murine models of the disease. These effects are associated with a decrease in lung tissue generation of pro-inflammatory cytokines by a mechanism related to downregulation of NF-κB phosphorylation.

Ingestive behavior and physiological parameters of goats fed diets containing peanut cake from biodiesel.

Science.gov (United States)

Silva, Thadeu Mariniello; Oliveira, Ronaldo Lopes; do Nascimento Júnior, Nilton Guedes; de Pellegrini, Caius Barcellos; Trajano, Jaqueline da Silva; Rocha, Tiago Cunha; Bezerra, Leilson Rocha; Borja, Máikal Souza

2016-01-01

The experiment was conducted to evaluate the ingestive behavior and physiological parameters of confined goats fed peanut cake instead of soybean meal in their feed. We used 40 goats that were ¾ Boer, uncastrated, and 5 months of age on average, with an average initial weight of 15.6 ± 2.7 kg. The treatments consisted of diets with different levels of peanut cake replacing soybean meal in the concentrate (0.0, 33.33, 66.67, and 100%). The experimental design was completely randomized, with four treatments and ten repetitions. For the evaluation of feeding behavior, single animals were observed every 5 min for 24 h on 3 days. The physiological responses (respiratory rate; heart rate; rectal temperature, obtained with a rectal thermometer; and surface temperature) of the animals were evaluated at 09:00 and 15:00 h. The replacement of soybean meal with peanut cake did not change (P > 0.05) feeding behavior. The physiological parameters of the animals (P behavior or physiological parameters of confined ¾ Boer goats.

Synthesis of leukotrienes labelled with deuterium: [11,12,14,15-2H4]-LTA4, -LTC4, -LTD4 and -LTE4

International Nuclear Information System (INIS)

Lellouche, J.P.; Aubert, F.; Noel, J.P.; Boullais, C.; Beaucourt, J.P.

1989-01-01

Semi-hydrogenation by D 2 gas on Lindlar catalyst of an acetylenic precursor led to [11,12,14,15- 2 H 4 ]-LTA 4 methyl ester. Nucleophilic opening of the epoxide ring by amino thioacids accorded, after saponification, the corresponding deuterated peptidoleukotrienes LTC 4 , LTD 4 and LTE 4 . (author)

Commensurately modulated 1/4 and 1/5 phases of deuterated betaine calcium chloride dihydrate: a neutron structural study

International Nuclear Information System (INIS)

Hernandez, O.; Cousson, A.; Kiat, J.M.; Ecole Centrale des Arts et Manufactures, 92 - Chatenay-Malabry; Paulus, W.; Technische Hochschule Aachen; Ezpeleta, J.M.; Zuniga, F.J.

1999-01-01

The structures of the commensurate 1/4 and 1/5 phases of the displacively modulated compound D-BCCD [deuterated betaine (trimethylammonioacetate) calcium chloride dihydrate, i.e. (CD 3 ) 3 NCD 2 COOCaCl 2 (D 2 O) 2 or CaCl 2 x C 5 D 11 NO 2 x 2D 2 O] have been determined by single-crystal neutron diffraction at 100 and 68 K, respectively. The structural model of the 1/4 phase is found to be quite different from that obtained previously from X-ray diffraction data of the hydrogenated compound. This discrepancy comes from the fact that X-ray irradiation induces in this compound an unusual time-dependent decrease of the intensity of high-order satellite diffraction peaks. As a consequence and due to the commensurate nature of the phases investigated, X-ray diffraction failed to detect the large anharmonicity of the structural modulation which is clearly present in the two structures determined by neutron diffraction. (orig.)

Physiological demands of downhill mountain biking.

Science.gov (United States)

Burr, Jamie F; Drury, C Taylor; Ivey, Adam C; Warburton, Darren E R

2012-12-01

Mountain biking is a popular recreational pursuit and the physiological demands of cross-country style riding have been well documented. However, little is known regarding the growing discipline of gravity-assisted downhill cycling. We characterised the physiological demands of downhill mountain biking under typical riding conditions. Riding oxygen consumption (VO(2)) and heart rate (HR) were measured on 11 male and eight female experienced downhill cyclists and compared with data during a standardised incremental to maximum (VO(2max)) exercise test. The mean VO(2) while riding was 23.1 ± 6.9 ml · kg(-1) · min(-1) or 52 ± 14% of VO(2max) with corresponding heart rates of 146 ± 11 bpm (80 ± 6% HRmax). Over 65% of the ride was in a zone at or above an intensity level associated with improvements in health-related fitness. However, the participants' heart rates and ratings of perceived exertion were artificially inflated in comparison with the actual metabolic demands of the downhill ride. Substantial muscular fatigue was evident in grip strength, which decreased 5.4 ± 9.4 kg (5.5 ± 11.2%, P = 0.03) post-ride. Participation in downhill mountain biking is associated with significant physiological demands, which are in a range associated with beneficial effects on health-related fitness.

Materials of yearly scientific assembly of Polish Chemical Society, Poznan 23-26 September 1996

International Nuclear Information System (INIS)

1996-01-01

The Scientific Assembly of Polish Chemical Society has been held in 1996 in Poznan. The general view on scientific progress of chemistry in Poland has been presented. The conference has been divided into 18 sessions covering the most important research fields in chemistry. The sessions topics were as follows: S-1 physical chemistry; S-2 photochemistry, radiation chemistry and chemical kinetics; S-3 catalysis; S-4 inorganic chemistry and coordination chemistry; S-5 organic chemistry; S-6 chemistry of hetero organic compounds; S-7 medical chemistry; S-8 crystallochemistry; S-9 environment protection; S-10 didactics in chemistry; S-11 analytical chemistry; S-12 chemical technology; S-13 chemical engineering; S-14 chemistry of polymers; S-15 young chemists forum; S-16 professor forum; S-17 membranes and membrane processes; S-18 supermolecular chemistry

Psychological and physiological responses following repeated peer death.

Directory of Open Access Journals (Sweden)

Judith Pizarro Andersen

Full Text Available Undergraduates at a university in the United States were exposed - directly and indirectly - to 14 peer deaths during one academic year. We examined how individual and social factors were associated with psychological (e.g., anxiety, depression, somatization and physiological (i.e., cortisol distress responses following this unexpected and repeated experience with loss.Two to three months after the final peer death, respondents (N = 122, 61% female, 18-23 years, M = 20.13, SD = 1.14 reported prior adverse experiences, degree of closeness with the deceased, acute responses to the peer deaths, ongoing distress responses, social support, support seeking, and media viewing. A subset (n = 24 returned hair samples for evaluation of cortisol responses during the previous 3 months.Ongoing psychological distress was associated with a prior interpersonal trauma, b fewer social supports, and c media exposure to news of the deaths (p's25 p/mg compared to individuals with one or two prior bereavement experiences (who were, on average, within the normal range, 10 to 25 p/mg (p<.05. Only 8% of the sample utilized available university psychological or physical health resources and support groups.Limited research has examined the psychological and physiological impact of exposure to chronic, repeated peer loss, despite the fact that there are groups of individuals (e.g., police, military soldiers that routinely face such exposures. Prior adversity appears to play a role in shaping psychological and physiological responses to repeated loss. This topic warrants further research given the health implications of repeated loss for individuals in high-risk occupations and university settings.

The physiological and biomechanical effects of forwards and reverse sports wheelchair propulsion.

Science.gov (United States)

Mason, Barry S; Lenton, John P; Goosey-Tolfrey, Victoria L

2015-07-01

To explore the physiological and biomechanical differences between forwards (FOR) and reverse (REV) sports wheelchair propulsion. Fourteen able-bodied males with previous wheelchair propulsion experience pushed a sports wheelchair on a single-roller ergometer in a FOR and REV direction at three sub-maximal speeds (4, 6, and 8 km/hour). Each trial lasted 3 minutes, and during the final minute physiological and biomechanical measures was collected. The physiological results revealed that oxygen uptake (1.51 ± 0.29 vs. 1.38 ± 0.26 L/minute, P = 0.005) and heart rate (121 ± 19 vs. 109 ± 14 beats/minute, P 0.05). However, greater mean resultant forces were applied during FOR (P kinematic adaptations in order to maintain constant speeds in REV.

Alteration of plant physiology by glyphosate and its by-product aminomethylphosphonic acid: an overview.

Science.gov (United States)

Gomes, Marcelo P; Smedbol, Elise; Chalifour, Annie; Hénault-Ethier, Louise; Labrecque, Michel; Lepage, Laurent; Lucotte, Marc; Juneau, Philippe

2014-09-01

It is generally claimed that glyphosate kills undesired plants by affecting the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) enzyme, disturbing the shikimate pathway. However, the mechanisms leading to plant death may also be related to secondary or indirect effects of glyphosate on plant physiology. Moreover, some plants can metabolize glyphosate to aminomethylphosphonic acid (AMPA) or be exposed to AMPA from different environmental matrices. AMPA is a recognized phytotoxin, and its co-occurrence with glyphosate could modify the effects of glyphosate on plant physiology. The present review provides an overall picture of alterations of plant physiology caused by environmental exposure to glyphosate and its metabolite AMPA, and summarizes their effects on several physiological processes. It particularly focuses on photosynthesis, from photochemical events to C assimilation and translocation, as well as oxidative stress. The effects of glyphosate and AMPA on several plant physiological processes have been linked, with the aim of better understanding their phytotoxicity and glyphosate herbicidal effects. © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Molecular and physiological manifestations and measurement of aging in humans.

Science.gov (United States)

Khan, Sadiya S; Singer, Benjamin D; Vaughan, Douglas E

2017-08-01

Biological aging is associated with a reduction in the reparative and regenerative potential in tissues and organs. This reduction manifests as a decreased physiological reserve in response to stress (termed homeostenosis) and a time-dependent failure of complex molecular mechanisms that cumulatively create disorder. Aging inevitably occurs with time in all organisms and emerges on a molecular, cellular, organ, and organismal level with genetic, epigenetic, and environmental modulators. Individuals with the same chronological age exhibit differential trajectories of age-related decline, and it follows that we should assess biological age distinctly from chronological age. In this review, we outline mechanisms of aging with attention to well-described molecular and cellular hallmarks and discuss physiological changes of aging at the organ-system level. We suggest methods to measure aging with attention to both molecular biology (e.g., telomere length and epigenetic marks) and physiological function (e.g., lung function and echocardiographic measurements). Finally, we propose a framework to integrate these molecular and physiological data into a composite score that measures biological aging in humans. Understanding the molecular and physiological phenomena that drive the complex and multifactorial processes underlying the variable pace of biological aging in humans will inform how researchers assess and investigate health and disease over the life course. This composite biological age score could be of use to researchers seeking to characterize normal, accelerated, and exceptionally successful aging as well as to assess the effect of interventions aimed at modulating human aging. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Sleep and Physiological Dysregulation: A Closer Look at Sleep Intraindividual Variability.

Science.gov (United States)

Bei, Bei; Seeman, Teresa E; Carroll, Judith E; Wiley, Joshua F

2017-09-01

Variable daily sleep (ie, higher intraindividual variability; IIV) is associated with negative health consequences, but potential physiological mechanisms are poorly understood. This study examined how the IIV of sleep timing, duration, and quality is associated with physiological dysregulation, with diurnal cortisol trajectories as a proximal outcome and allostatic load (AL) as a multisystem distal outcome. Participants are 436 adults (Mage ± standard deviation = 54.1 ± 11.7, 60.3% women) from the Midlife in the United States study. Sleep was objectively assessed using 7-day actigraphy. Diurnal cortisol was measured via saliva samples (four/day for 4 consecutive days). AL was measured using 23 biomarkers from seven systems (inflammatory, hypothalamic-pituitary-adrenal axis, metabolic glucose and lipid, cardiovascular, parasympathetic, sympathetic) using a validated bifactor model. Linear and quadratic effects of sleep IIV were estimated using a validated Bayesian model. Controlling for covariates, more variable sleep timing (p = .04 for risetime, p = .097 for bedtime) and total sleep time (TST; p = .02), but not mean sleep variables, were associated with flatter cortisol diurnal slope. More variable sleep onset latency and wake after sleep onset, later average bedtime, and shorter TST were associated with higher AL adjusting for age and sex (p-values sleep patterns were associated with blunted diurnal cortisol trajectories but not with higher multisystem physiological dysregulation. The associations between sleep IIV and overall health are likely complex, including multiple biopsychosocial determinants and require further investigation. © Sleep Research Society 2017. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.

Multi-sector thermo-physiological head simulator for headgear research

Science.gov (United States)

Martinez, Natividad; Psikuta, Agnes; Corberán, José Miguel; Rossi, René M.; Annaheim, Simon

2017-02-01

A novel thermo-physiological human head simulator for headgear testing was developed by coupling a thermal head manikin with a thermo-physiological model. As the heat flux at head-site is directly measured by the head manikin, this method provides a realistic quantification of the heat transfer phenomena occurring in the headgear, such as moisture absorption-desorption cycles, condensation, or moisture migration across clothing layers. Before coupling, the opportunities of the head manikin for representing the human physiology were evaluated separately. The evaluation revealed reduced precision in forehead and face temperature predictions under extreme heterogeneous temperature distributions and no initial limitation for simulating temperature changes observed in the human physiology. The thermo-physiological model predicted higher sweat rates when applied for coupled than for pure virtual simulations. After coupling, the thermo-physiological human head simulator was validated using eight human experiments. It precisely predicted core, mean skin, and forehead temperatures with average rmsd values within the average experimental standard deviation (rmsd of 0.20 ± 0.15, 0.83 ± 0.34, and 1.04 ± 0.54 °C, respectively). However, in case of forehead, precision was lower for the exposures including activity than for the sedentary exposures. The representation of the human sweat evaporation could be affected by a reduced evaporation efficiency and the manikin sweat dynamics. The industry will benefit from this thermo-physiological human head simulator leading to the development of helmet designs with enhanced thermal comfort and, therefore, with higher acceptance by users.

Multi-sector thermo-physiological head simulator for headgear research.

Science.gov (United States)

Martinez, Natividad; Psikuta, Agnes; Corberán, José Miguel; Rossi, René M; Annaheim, Simon

2017-02-01

A novel thermo-physiological human head simulator for headgear testing was developed by coupling a thermal head manikin with a thermo-physiological model. As the heat flux at head-site is directly measured by the head manikin, this method provides a realistic quantification of the heat transfer phenomena occurring in the headgear, such as moisture absorption-desorption cycles, condensation, or moisture migration across clothing layers. Before coupling, the opportunities of the head manikin for representing the human physiology were evaluated separately. The evaluation revealed reduced precision in forehead and face temperature predictions under extreme heterogeneous temperature distributions and no initial limitation for simulating temperature changes observed in the human physiology. The thermo-physiological model predicted higher sweat rates when applied for coupled than for pure virtual simulations. After coupling, the thermo-physiological human head simulator was validated using eight human experiments. It precisely predicted core, mean skin, and forehead temperatures with average rmsd values within the average experimental standard deviation (rmsd of 0.20 ± 0.15, 0.83 ± 0.34, and 1.04 ± 0.54 °C, respectively). However, in case of forehead, precision was lower for the exposures including activity than for the sedentary exposures. The representation of the human sweat evaporation could be affected by a reduced evaporation efficiency and the manikin sweat dynamics. The industry will benefit from this thermo-physiological human head simulator leading to the development of helmet designs with enhanced thermal comfort and, therefore, with higher acceptance by users.

Physiological stress response patterns during a blood donation.

Science.gov (United States)

Hoogerwerf, M D; Veldhuizen, I J T; Tarvainen, M P; Merz, E-M; Huis In 't Veld, E M J; de Kort, W L A M; Sluiter, J K; Frings-Dresen, M H W

2018-03-24

Donating blood is associated with increased psychological stress. This study investigates whether a blood donation induces physiological stress and if response patterns differ by gender, donation experience and non-acute stress. In 372 donors, physiological stress [blood pressure, pulse rate, pulse rate variability (PRV)] was measured at seven moments during routine donation. PRV was assessed using time domain [root mean square of successive differences (RMSSD)] and frequency domain [high frequency (HF) and low frequency (LF) power] parameters. Non-acute stress was assessed by questionnaire. Shape and significance of time course patterns were assessed by fitting multilevel models for each stress measure and comparing men and women, first-time and experienced donors, and donors with high and low levels of non-acute stress. Significant response patterns were found for all stress measures, where levels of systolic blood pressure (F(1,1315) = 24·2, P blood pressure (F(1,1326) = 50·9, P blood pressure/pulse rate in women; higher pulse rate in first-time donors; higher RMSSD at arrival and from screening until leaving in first-time donors; and higher LF and HF in first-time donors. This study shows an increase in physiological stress related to needle insertion, followed by a decrease when leaving the donation centre. Some group effects were also found. © 2018 International Society of Blood Transfusion.

Geophysical logging and imaging of characterisation drillholes ONK-KR13, ONK-KR14 and ONK-KR15

International Nuclear Information System (INIS)

Tarvainen, A.-M.

2011-08-01

Suomen Malmi Oy conducted geophysical drillhole logging as well as optical and acoustic imaging of drillholes ONK-KR13, ONK-KR14 and ONK-KR15 at ONKALO in June-July 2010 and in March 2011. The survey is a part of Posiva Oy's detailed investigation program for the final disposal of spent nuclear fuel. The assignment included the field work and data processing. The report describes field operation, equipment as well as processing procedures and shows the obtained results and an analysis of their quality in the appendices. The raw and processed data are delivered digitally in WellCAD, PDF and Excel format. (orig.)

Physiological and psychological effects of gardening activity in older adults.

Science.gov (United States)

Hassan, Ahmad; Qibing, Chen; Tao, Jiang

2018-04-06

Gardening has long been one of most enjoyable pastimes among older adults. Whether gardening activities contribute to the well-being of older adults is a major question. Therefore, the aim of the present study was to clarify the psychophysiological relaxing effects of gardening activities on older adults living in modern institutional care. The study participants were 40 older women aged 79.5 ± 8.09 years (mean ± SD). A cross-over study design was used to investigate the physiological and psychological responses to environments with and without plants. Physiological evaluation was carried out using blood pressure and electroencephalography, and psychological evaluation was carried out using the State-Trait Anxiety Inventory and Semantic Differential method. Blood pressure was significantly lower, and changes in brainwaves were observed. Psychological responses showed that participants were more "comfortable and relaxed" after the plant task than after the control task. In addition, total anxiety levels were significantly lower after carrying out the plant task than after the control task. Our research suggests that gardening activities might enhance physiological and psychological relaxation in older adults. Geriatr Gerontol Int 2018; ••: ••-••. © 2018 Japan Geriatrics Society.

Effective mass of the four-flux composite fermion at ν=1/4

International Nuclear Information System (INIS)

Pan, W.; Stormer, H. L.; Tsui, D. C.; Pfeiffer, L. N.; Baldwin, K. W.; West, K. W.

2000-01-01

We have measured the effective mass (m * ) of the four flux composite fermion at Landau-level filling factor ν=1/4 ( 4 CF), using the activation energy gaps at the fractional quantum Hall effect states ν=2/7, 3/11, and 4/15 and the temperature dependence of the Shubnikov-de Haas (SdH) oscillations around ν=1/4. We find that the energy gaps show a linear dependence on the effective magnetic field B eff (≡B-B ν=1/4 ), and from this linear dependence we obtain m * =1.0m e and a disorder broadening Γ∼1 K for a sample of density n=0.87x10 11 cm -2 . The m * deduced from the temperature dependence of the SdH effect shows large differences for ν>1/4 and ν 1/4, m * ∼1.0m e . It scales as √(B ν ) with the mass derived from the data around ν=1/2 and shows an increase in m * as ν→1/4, resembling the findings around ν=1/2. For ν * increases rapidly with increasing B eff and can be described by m * /m e =-3.3+5.7B eff . This anomalous dependence on B eff is precursory to the formation of the insulating phase at still lower filling. (c) 2000 The American Physical Society

Use of a physiological profile to document motor impairment in ageing and in clinical groups.

Science.gov (United States)

Lord, S R; Delbaere, K; Gandevia, S C

2016-08-15

Ageing decreases exercise performance and is frequently accompanied by reductions in cognitive performance. Deterioration in the physiological capacity to stand, locomote and exercise can manifest itself as falling over and represents a significant deterioration in sensorimotor control. In the elderly, falling leads to serious morbidity and mortality with major societal costs. Measurement of a suite of physiological capacities that are required for successful motor performance (including vision, muscle strength, proprioception and balance) has been used to produce a physiological profile assessment (PPA) which has been tracked over the age spectrum and in different diseases (e.g. multiple sclerosis, Parkinson's disease). As well as measures of specific physiological capacities, the PPA generates an overall 'score' which quantitatively measures an individual's cumulative risk of falling. The present review collates data from the PPA (and the physiological capacities it measures) as well as its use in strategies to reduce falls in the elderly and those with different diseases. We emphasise that (i) motor impairment arises via reductions in a wide range of sensorimotor abilities; (ii) the PPA approach not only gives a snapshot of the physiological capacity of an individual, but it also gives insight into the deficits among groups of individuals with particular diseases; and (iii) deficits in seemingly restricted and disparate physiological domains (e.g. vision, strength, cognition) are funnelled into impairments in tasks requiring upright balance. Motor impairments become more prevalent with ageing but careful physiological measurement and appropriate interventions offer a way to maximise health across the lifespan. © 2015 The Authors. The Journal of Physiology © 2015 The Physiological Society.

Conservation Physiology and Conservation Pathogens: White-Nose Syndrome and Integrative Biology for Host-Pathogen Systems.

Science.gov (United States)

Willis, Craig K R

2015-10-01

Conservation physiology aims to apply an understanding of physiological mechanisms to management of imperiled species, populations, or ecosystems. One challenge for physiologists hoping to apply their expertise to conservation is connecting the mechanisms we study, often in the laboratory, with the vital rates of populations in the wild. There is growing appreciation that infectious pathogens can threaten populations and species, and represent an important issue for conservation. Conservation physiology has much to offer in terms of addressing the threat posed to some host species by infectious pathogens. At the same time, the well-developed theoretical framework of disease ecology could provide a model to help advance the application of physiology to a range of other conservation issues. Here, I use white-nose syndrome (WNS) in hibernating North American bats as an example of a conservation problem for which integrative physiological research has been a critical part of research and management. The response to WNS highlights the importance of a well-developed theoretical framework for the application of conservation physiology to a particular threat. I review what is known about physiological mechanisms associated with mortality from WNS and emphasize the value of combining a strong theoretical background with integrative physiological studies in order to connect physiological mechanisms with population processes and thereby maximize the potential benefits of conservation physiology. © The Author 2015. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

Total protein synthesis in elderly people; a comparison of results with (/sup 15/N)glycine and (/sup 14/C)leucine

Energy Technology Data Exchange (ETDEWEB)

Golden, M H.N.; Waterlow, J C [London School of Hygiene and Tropical Medicine (UK)

1977-09-01

Total body protein turnover was studied in six elderly patients. During the study they were fed by continuous infusion of a liquid formula through a nasogastric tube. L-(1-/sup 14/C)leucine and (/sup 15/N)-glycine were infused at a constant rate for 30 h. The labelled glycine was infused into the intragastric line; the labelled leucine was given either by this route or intravenously. The specific radioactivity of free leucine in plasma and the rate of output of /sup 14/CO/sub 2/ in expired air both reached a plateau at 10 h, and remained constant until the end of the infusion at 30 h. The /sup 15/N abundance in urinary urea and total N was very similar. In neither was a plateau reached by 30 h but in four out of the six patients the abundance in urinary NH/sub 4//sup +/ had attained a plateau by the end of the infusion. Flux rates and rates of protein synthesis were calculated in four ways and a comparison of methods was used to examine the validity of the assumptions on which the different methods depended. The results suggest that the rate of protein turnover is reduced in the elderly, compared with younger subjects.

A recurrent human papillomavirus integration site at chromosome region 12q14-q15 in SW756 and SK-v cell lines derived from genital tumors

International Nuclear Information System (INIS)

Sastre-Garau, X.; Couturier, J.; Favre, M.; Orth, G.

1995-01-01

The SW756 cell line, derived from an invasive cancer of the uterine cervix, harbours integrated human papillomavirus (HPV) 18 DNA sequences which have been located in chromosome band 12q13. By in situ hybridization experiments with tritiated and digoxigenin-labelled HPV18 probes on R-banded chromosomes, we now localize the integrated viral sequences in 12q14-q15. Interestingly, we have previously localized integrated HPV16 sequences in the same chromosomal region in SK-v cells, derived from a pre-invasive vulvar neoplasia. The chromosomal region 12q14-q15 could thus correspond to a preferential site for the integration of HPV DNA in genital tumors. (authors). 29 refs., 2 figs

RTN Winter School on Strings, Supergravity and Gauge Theories (1/5)

CERN Multimedia

CERN. Geneva

2006-01-01

9.30-10.30 A. Dabholkar Black Holes Entropy and Microstate Counting (1/4) 10.30-11.30 M. Grana Flux Compactifications and Generalized Geometry (1/4) 12.15-13.15 B. Craps Big Bang Models in String Theory (1/4) 14.30-15.30 A. Dabholkar Black Holes Entropy and Microstate Counting (2/4) 15.30-16.30 S. Minwalla Large N Thermal Phase Transitions (1/4) 17.00 Discussion Organiser(s): CERN and Neuchâtel UniversityMore information: http://www.unine.ch/phys/string/rtn-school/index.php

15-Deoxy-{Delta}{sup 12,14}-prostaglandin J{sub 2} impairs the functions of histone acetyltransferases through their insolubilization in cells

Energy Technology Data Exchange (ETDEWEB)

Hironaka, Asako [Department of Biochemistry, Nara Medical University, Shijo-Cho 840, Kashihara, Nara 634-8521 (Japan); Morisugi, Toshiaki; Kawakami, Tetsuji [Department of Oral and Maxillofacial Surgery, Nara Medical University, Shijo-Cho 840, Kashihara, Nara 634-8521 (Japan); Miyagi, Ikuko [Laboratory of Biometabolic Chemistry, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara-Cho, Okinawa 903-0215 (Japan); Tanaka, Yasuharu, E-mail: yatanaka@med.u-ryukyu.ac.jp [Laboratory of Biometabolic Chemistry, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara-Cho, Okinawa 903-0215 (Japan)

2009-12-11

The cyclopentenonic prostaglandin 15-deoxy-{Delta}{sup 12,14}-PG J{sub 2} (15d-PGJ{sub 2}) is a metabolite derived from PGD{sub 2}. Although 15d-PGJ{sub 2} has been demonstrated to be a potent ligand for peroxisome proliferator activated receptor {gamma} (PPAR{gamma}), the functions are not fully understood. In order to examine the effect of 15d-PGJ{sub 2} on histone acetyltransferases (HATs), several lines of cell including mouse embryonic fibroblast (MEF) cells were exposed to 15d-PGJ{sub 2}. Three types of HAT, p300, CREB-binding protein (CBP), and p300/CBP-associated factor (PCAF), selectively disappeared from the soluble fraction in time- and dose-dependent manners. Inversely, HATs in the insoluble fraction increased, suggesting their conformational changes. The decrease in the soluble form of HATs resulted in the attenuation of NF-{kappa}B-, p53-, and heat shock factor-dependent reporter gene expressions, implying that the insoluble HATs are inactive. The resultant insoluble PCAF and p300 seemed to be digested by proteasome, because proteasome inhibitors caused the accumulation of insoluble HATs. Taken together, these results indicate that 15d-PGJ{sub 2} attenuates some gene expressions that require HATs. This inhibitory action of 15d-PGJ{sub 2} on the function of HATs was independent of PPAR{gamma}, because PPAR{gamma} agonists could not mimick 15d-PGJ{sub 2} and PPAR{gamma} antagonists did not inhibit 15d-PGJ{sub 2}.

Evaluation of Various Morpho-Physiological and Growth Traits of Dual Purpose Wheat under Early Sowing Dates

International Nuclear Information System (INIS)

Munsif, F.; Arif, M.; Rasul, F.

2016-01-01

The use of wheat as dual purpose crop (for fodder and grain) is considered as promising agronomic management practice fulfilling human and animal need at same time. These expectations are largely found on positive experiences by growing wheat as dual purpose crop throughout the world. However, the validity of these results in Pakistan needs confirmation from field experiments under various sowing date and potential cultivars. The impact of cutting and sowing date on morphological and physiological traits of already existing wheat cultivars was evaluated at Agricultural Research Farm of The University of Agriculture, Peshawar Pakistan in winter 2010-2011 and 2011-2012. Three sowing dates i.e. 15th October, 30th October and 14th November and six wheat cultivars (Ghaznavi-98, Fakhre-Sarhad (FS)-99, Ghaznavi-98, Saleem-2000, Uqab-2000 and Siran-2008) were compared for dual purpose wheat production during the course of experiment. Findings showed that significant reduction were recorded in nodes tiller/sup -1/, plant height, spike weight and grains weight spike/sup -1/ when sowing of wheat delayed from 15th and 30th October to 15th November. Considerable variations were also noted in nodes tiller/sup -1/, internodes length and leaf area index, plant height and lodging score among wheat cultivars but it was mainly due to their genetic characteristic not because of cutting treatment. It was observed that cutting caused 5.5, 12.1, 6.2, 4.1, 25.9, 7.1,6.6% reduction in wheat leaf area, leaf area index, internode length, plant height, lodging score, spike weight and grains weight spike/sup -1/, respectively over non cut plots in both year of the experiment. Interestingly, no-significant change was noted in spike length and number of nodes tiller/sup -1/ under cut and no cut plots. The conclusive findings suggested that optimum sowing date (15th and 30th October) for all wheat cultivars could be utilized as potential source of dual purpose wheat for substantial reduction of

Physiological Indicators of Workload in a Remotely Piloted Aircraft Simulation

Science.gov (United States)

2015-10-01

cognitive workload. That is, both cognitive underload and overload can negatively impact performance (Young & Stanton, 2002). One solution to...Report contains color. 14. ABSTRACT Toward preventing performance decrements associated with mental overload in remotely piloted aircraft (RPA...operations, the current research investigated the feasibility of using physiological measures to assess cognitive workload. Two RPA operators were

Cross-population validation of statistical distance as a measure of physiological dysregulation during aging.

Science.gov (United States)

Cohen, Alan A; Milot, Emmanuel; Li, Qing; Legault, Véronique; Fried, Linda P; Ferrucci, Luigi

2014-09-01

Measuring physiological dysregulation during aging could be a key tool both to understand underlying aging mechanisms and to predict clinical outcomes in patients. However, most existing indices are either circular or hard to interpret biologically. Recently, we showed that statistical distance of 14 common blood biomarkers (a measure of how strange an individual's biomarker profile is) was associated with age and mortality in the WHAS II data set, validating its use as a measure of physiological dysregulation. Here, we extend the analyses to other data sets (WHAS I and InCHIANTI) to assess the stability of the measure across populations. We found that the statistical criteria used to determine the original 14 biomarkers produced diverging results across populations; in other words, had we started with a different data set, we would have chosen a different set of markers. Nonetheless, the same 14 markers (or the subset of 12 available for InCHIANTI) produced highly similar predictions of age and mortality. We include analyses of all combinatorial subsets of the markers and show that results do not depend much on biomarker choice or data set, but that more markers produce a stronger signal. We conclude that statistical distance as a measure of physiological dysregulation is stable across populations in Europe and North America. Copyright © 2014 Elsevier Inc. All rights reserved.

History, achievements, and future challenges of Japanse Society of Soil Science and Plant Nutrition

Science.gov (United States)

Kosaki, Takashi

2013-04-01

Modern soil science was introduced just after the reformation of Japan in 1867 by Max Fesca, Oskar Kellner and other German teachers together with their Japanese students, who were traced back to Justus von Liebig and thus started studying and teaching soils based on agrogeology and agricultural chemistry. After the German teachers left, the graduates from agricultural colleges formed the Foundation of Agricultural Sciences in 1887, based on which the Society of the Science of Soil and Manure, Japan, was established in 1927. The research, education and extension activities then expanded to Korea, Manchuria and Inner Mongolia as well as Taiwan and Sakhalin in accordance with a military invasion to China and Southeast Asian countries until the end of WWII. After WWII together with the reformation guided by the General Headquarters (GHQ) of the Allied Forces, soils research and educational units increased in number in the universities and governmental institutions. The society started publication of the journal in English, "Soils and Plant Food" in 1955, which was renamed to "Soil Science and Plant Nutrition (SSPN)" in 1961. There formed a variety of discussion groups in the society such as soil microbiology, pedology, clay science, soil physics, plant physiology, and forest environment, which became independent in the 1960s. Economic growth of Japan in the 1970s accomplished self-sufficiency in rice production and extended the range of crop to grow, however, a variety of environmental issues came out. A new division was established in the society for solving soil-related environmental problems. The society became more involved in international activities and hosted a number of international conferences, workshops, etc., the most significant of which was the 14th International Congress of Soil Science at Kyoto in 1990. The society proposed there a regional organization to cope with the unique issues, e.g. improvement of paddy rice cultivation, for Asian countries and

Neurosurgery certification in member societies of the World Federation of Neurosurgical Societies: Asia.

Science.gov (United States)

Gasco, Jaime; Braun, Jonathan D; McCutcheon, Ian E; Black, Peter M

2011-01-01

To objectively compare the complexity and diversity of the certification process in neurological surgery in member societies of the World Federation of Neurosurgical Societies. This study centers in continental Asia. We provide here an analysis based on the responses provided to a 13-item survey. The data received were analyzed, and three Regional Complexity Scores (RCS) were designed. To compare national board experience, eligibility requirements for access to the certification process, and the obligatory nature of the examinations, an RCS-Organizational score was created (20 points maximum). To analyze the complexity of the examination, an RCS-Components score was designed (20 points maximum). The sum of both is presented in a Global RCS score. Only those countries that responded to the survey and presented nationwide homogeneity in the conduction of neurosurgery examinations could be included within the scoring system. In addition, a descriptive summary of the certification process per responding society is also provided. On the basis of the data provided by our RCS system, the highest global RCS was achieved by South Korea and Malaysia (21/40 points) followed by the joint examination of Singapore and Hong-Kong (FRCS-Ed) (20/40 points), Japan (17/40 points), the Philippines (15/40 points), and Taiwan (13 points). The experience from these leading countries should be of value to all countries within Asia. Copyright © 2011 Elsevier Inc. All rights reserved.

The complex transfer reaction (14C, 15O) on Ni, Zn and Ge targets: existence and mass of 69Ni

International Nuclear Information System (INIS)

Dessagne, P.; Bernas, M.; Langevin, M.; Pougheon, F.; Roussel, P.; Morrison, G.C.

1984-01-01

The ( 14 C, 15 O) complex transfer reaction has been studied at 72 MeV incident energy on 58 Ni, 60 Ni, 62 Ni, 64 Ni, 68 Zn, 70 Zn and 74 Ge, 76 Ge targets. Spectra and differential cross sections have been measured in a 5 0 angular range centred around a laboratory angle of 6 0 . The nucleus 69 Ni has been observed and its mass determined for the first time

Theory of ultra dense matter and the dynamics of high energy interactions involving nuclei. Progress report, December 15, 1993--December 14, 1994

Energy Technology Data Exchange (ETDEWEB)

Gyulassy, M.

1994-09-12

This report summarizes the progress made during the second year of the three year DOE agreement DE-FG02-93ER40764 on theoretical nuclear physics research performed at the Columbia University and presents a detailed budget adjustment for the third year period December 15, 1994 to December 14, 1995. Sections 1.1 to 1.8 highlight the technical progress made on the following general areas: Multiple scattering and radiative processes in QCD; the quark-gluon plasma transition in nuclear matter; QCD transport theory and dissipative mechanism in dense matter; phenomenological models of high energy interactions involving nuclei; signatures of quark-gluon plasma formation in A+A; neurocomputation theory. Section 2 contains a bibliography of published papers and invited conference papers. Section 3 lists the Columbia nuclear theory members for the December 15, 1994 to December 14, 1995 period. Finally, the budget adjustment requesting $319,830 for the third year relative to the original $320,000 is presented in section 6. Copies of the research papers accompany this report.

Theory of ultra dense matter and the dynamics of high energy interactions involving nuclei. Progress report, December 15, 1993--December 14, 1994

International Nuclear Information System (INIS)

Gyulassy, M.

1994-01-01

This report summarizes the progress made during the second year of the three year DOE agreement DE-FG02-93ER40764 on theoretical nuclear physics research performed at the Columbia University and presents a detailed budget adjustment for the third year period December 15, 1994 to December 14, 1995. Sections 1.1 to 1.8 highlight the technical progress made on the following general areas: Multiple scattering and radiative processes in QCD; the quark-gluon plasma transition in nuclear matter; QCD transport theory and dissipative mechanism in dense matter; phenomenological models of high energy interactions involving nuclei; signatures of quark-gluon plasma formation in A+A; neurocomputation theory. Section 2 contains a bibliography of published papers and invited conference papers. Section 3 lists the Columbia nuclear theory members for the December 15, 1994 to December 14, 1995 period. Finally, the budget adjustment requesting $319,830 for the third year relative to the original $320,000 is presented in section 6. Copies of the research papers accompany this report

Aerospace and energetics research program: Annual report, 15 August 1987--14 August 1988

International Nuclear Information System (INIS)

Vlases, G.C.; Pietrzyk, Z.A.

1989-01-01

This document reports on work accomplished under grant DE-FG06-87ER53243 for the period August 15, 1987 - August 14, 1988, on the Coaxial Slow Source device (CSS). The CSS project was initiated within the UW CT program following a favorable peer review in March 1984, and began operating in February 1985. The CSS was conceived to provide an alternative generation scheme for ERC's which is more amenable to scaling to reactor size devices by virtue of its low voltage, slow rise time characteristics. Prior to the present reporting period it had already been found possible to generate the desired ''annular FRC's'' over a wide range of fill pressures, using applied loop voltages of 2 kV with a rise time of about 30 μs. Considerable progress has been made during the last 12 months. A substantially upgraded device, which we call CSS-U, was built and put into operation in an expanded 1500 ft 2 laboratory. The diagnostics were also considerably upgraded. Initial operation of the CSS-U has provided new information into the nature of CSS discharged. 8 refs., 35 figs., 3 tabs

Analysis of Experts’ Quantitative Assessment of Adolescent Basketball Players and the Role of Anthropometric and Physiological Attributes

Directory of Open Access Journals (Sweden)

Štrumbelj Erik

2014-10-01

Full Text Available In this paper, we investigated two questions: (1 can measurements of anthropometric and physiological attributes substitute for expert assessment of adolescent basketball players, and (2 how much does the quantitative assessment of a player vary among experts? The first question is relevant to the potential simplification of the player selection process. The second question pertains directly to the validity of expert quantitative assessment. Our research was based on data from 148 U14 female and male basketball players. For each player, an array of anthropometric and physiological attributes was recorded, including body height, body mass, BMI, and several motor skill tests. Furthermore, each player's current ability and potential ability were quantitatively evaluated by two different experts from a group of seven experts. Analysis of the recorded data showed that the anthropometric and physiological attributes explained between 15% and 40% of the variance in experts’ scores. The primary predictive attributes were speed and agility (for predicting current ability and body height and growth potential (for predicting potential ability. We concluded that these attributes were not sufficiently informative to act as a substitute for expert assessment of the players’ current or potential ability. There is substantial variability in different experts' scores of the same player’s ability. However, the differences between experts are mostly in scale, and the relationships between experts’ scores are monotonic. That is, different experts rank players on ability very similarly, but their scores are not well calibrated.

Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 2017; Session "Neonatal Gastrointestinal Physiology and NEC"

Directory of Open Access Journals (Sweden)

--- Various Authors

2017-10-01

Full Text Available Selected Abstracts of the 2nd Congress of joint European Neonatal Societies (jENS 2017; Venice (Italy; October 31-November 4, 201758th ESPR Annual Meeting, 7th International Congress of UENPS, 3rd International Congress of EFCNIORGANIZING INSTITUTIONSEuropean Society for Paediatric Research (ESPR, European Society for Neonatology (ESN, Union of European Neonatal & Perinatal Societies (UENPS, European Foundation for the Care of Newborn Infants (EFCNIORGANIZING COMMITTEELuc Zimmermann (President of ESPR, Morten Breindahl (President of ESN, Manuel Sánchez Luna (President of UENPS, Silke Mader (Chairwoman of the Executive Board and Co-Founder of EFCNISCIENTIFIC COMMITTEEVirgilio P. Carnielli (Congress President Chair, Pierre Gressens (Past Scientific President, Umberto Simeoni, Manon Benders, Neil Marlow, Ola D. Saugstad, Petra Hüppi, Agnes van den HoogenSession "Neonatal Gastrointestinal Physiology and NEC"ABS 1. DETRIMENTAL MUCOSAL EFFECT OF IBUPROFEN IN THE IMMATURE HUMAN INTESTINE • E. Tremblay, E. Ferretti, M.-P. Thibault, D. Grynspan, K.M. Burghardt, M. Bettolli, C. Babakissa, E. Levy, J.-F. Beaulieu; Research Consortium on Child Intestinal InflammationABS 2. CORRELATION BETWEEN CALPROTECTIN LEVELS IN MECONIUM AND VITAMIN D STATUS IN CORD BLOOD: ASSOCIATION WITH INTESTINAL DISTRESS DURING NEONATAL PERIOD • S.H. Park, W.H. Kim, Y.M. LeeABS 3. COMPARISON OF FECAL CALPROTECTIN LEVELS ACCORDING TO FEEDING KINDS IN VERY PRETERM INFANTS • J.H. Park, N.H. Lee, S.Y. Shin, C.S. Kim, S.L. Lee, W.M. LeeABS 4. NEONATAL MORBIDITY OF EXTREME PRETERM INFANTS BEFORE AND AFTER THE INTRODUCTION OF A DONOR HUMAN MILK BANK AT THE PERINATAL CENTER GROßHADERN • V. Lieftüchter, M. Kujawa, A. Schuze, A.W. Flemmer, S. Herber-JonatABS 5. IS NEAR INFRARED SPECTROSCOPY A RELIABLE TECHNIQUE TO MEASURE GUT PERFUSION IN PRETERM INFANTS? • J. Banerjee, T.S. Leung, N. AladangadyABS 6. EARLY BIOCHEMICAL MARKERS ASSOCIATED WITH DEVELOPMENT OF NECROTIZING

Effect of a puzzle on the process of students' learning about cardiac physiology.

Science.gov (United States)

Cardozo, Lais Tono; Miranda, Aline Soares; Moura, Maria José Costa Sampaio; Marcondes, Fernanda Klein

2016-09-01

The aim of the present study was to evaluate the effects of using a puzzle to learn about cardiac physiology. Students were divided into control and game groups. In class 1, the control group had a 2-h theoretical class about cardiac physiology, including a detailed description of the phases of the cardiac cycle, whereas the game group had a 50-min theoretical class without the description of the cardiac cycle. In class 2, the control group did an assessment exercise before an activity with the cardiac puzzle and the game group answered questions after the above-mentioned activity. While solving the puzzle, the students had to describe the cardiac cycle by relating the concepts of heart morphology and physiology. To evaluate short-term learning, the number of wrong answers and grades in the assessment exercise were compared between the control and game groups. To evaluate medium-term learning, we compared the grades obtained by students of the control and game groups in questions about cardiac physiology that formed part of the academic exam. In the assessment exercise, the game group presented a lower number of errors and higher score compared with the control group. In the academic exam, applied after both groups had used the puzzle, there was no difference in the scores obtained by the control and game groups in questions about cardiac physiology. These results showed a positive effect of the puzzle on students' learning about cardiac physiology compared with those not using the puzzle. Copyright © 2016 The American Physiological Society.

Search for a resonance in the 14N(p,γ)15O reaction at Ep=127 keV

International Nuclear Information System (INIS)

Runkle, R.C.; Champagne, A.E.; Fox, C.; Iliadis, C.; Pollanen, J.; Stephan, A.; Westerfeldt, C.

2002-01-01

The 14 N(p,γ) 15 O reaction regulates the energy produced by the CN cycle in main-sequence stars and in red giants. Recently, preliminary evidence was presented for a new resonance in this reaction, which would significantly increase the reaction rate for temperatures near 10 8 K. We have attempted to confirm this result and find no indication of a resonance near E p lab =127 keV. Our upper limit on its strength is ωγ≤32 neV (95% C.L.), which is more than 2 orders of magnitude below the previously reported value

An emerging paradigm for teaching human anatomy and physiology

African Journals Online (AJOL)

Rabab El-Sayed Hassan El-Sayed

2013-03-15

Mar 15, 2013 ... information about the anatomy and physiology of human ... tional curriculum in a range of teaching fields that are based ..... et al.,47 who were studying the acceptance and benefits of vi- .... Foreign language teaching methods: Culture lesson 3: the case for .... vations in integrating ICT in education, vol. 3.

Exercise increases circulating GDF15 in humans

DEFF Research Database (Denmark)

Kleinert, Maximilian; Clemmensen, Christoffer; Sjøberg, Kim Anker

2018-01-01

OBJECTIVE: The growth differentiation factor 15 (GDF15) is a stress-sensitive circulating factor that regulates systemic energy balance. Since exercise is a transient physiological stress that has pleiotropic effects on whole-body energy metabolism, we herein explored the effect of exercise on a......) circulating GDF15 levels and b) GDF15 release from skeletal muscle in humans. METHODS: Seven healthy males either rested or exercised at 67% of their VO2max for 1 h and blood was sampled from the femoral artery and femoral vein before, during, and after exercise. Plasma GDF15 concentrations were determined...... in these samples. RESULTS: Plasma GDF15 levels increased 34% with exercise (p exercise. There was no difference between the arterial and venous GDF15 concentration before, during, and after exercise. During...

Earliest porotic hyperostosis on a 1.5-million-year-old hominin, olduvai gorge, Tanzania.

Directory of Open Access Journals (Sweden)

Manuel Domínguez-Rodrigo

Full Text Available Meat-eating was an important factor affecting early hominin brain expansion, social organization and geographic movement. Stone tool butchery marks on ungulate fossils in several African archaeological assemblages demonstrate a significant level of carnivory by Pleistocene hominins, but the discovery at Olduvai Gorge of a child's pathological cranial fragments indicates that some hominins probably experienced scarcity of animal foods during various stages of their life histories. The child's parietal fragments, excavated from 1.5-million-year-old sediments, show porotic hyperostosis, a pathology associated with anemia. Nutritional deficiencies, including anemia, are most common at weaning, when children lose passive immunity received through their mothers' milk. Our results suggest, alternatively, that (1 the developmentally disruptive potential of weaning reached far beyond sedentary Holocene food-producing societies and into the early Pleistocene, or that (2 a hominin mother's meat-deficient diet negatively altered the nutritional content of her breast milk to the extent that her nursing child ultimately died from malnourishment. Either way, this discovery highlights that by at least 1.5 million years ago early human physiology was already adapted to a diet that included the regular consumption of meat.

15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) mediates repression of TNF-α by decreasing levels of acetylated histone H3 and H4 at its promoter

International Nuclear Information System (INIS)

Engdahl, Ryan; Monroy, M. Alexandra; Daly, John M.

2007-01-01

Prostaglandin metabolite 15-Deoxy-Δ 12,14 -prostaglandin J2 (15d-PGJ2) is known to inhibit a number of pro-inflammatory cytokines as well as being a ligand for nuclear receptor PPARγ. We investigated the ability of 15d-PGJ2 to inhibit TNF-α gene expression through mechanisms that involve histone modification. Pretreatment with 15d-PGJ2 (10 μM) inhibited LPS-stimulated TNF-α mRNA in THP-1 monocytes or PMA-differentiated cells to nearly basal levels. A specific PPARγ ligand, GW1929, failed to inhibit LPS-induced TNF-α mRNA expression nor did a PPARγ antagonist, GW9662, alter the repression of TNF-α mRNA in LPS-stimulated cells pretreated with 15d-PGJ2 suggesting a PPARγ-independent inhibition of TNF-α mRNA in THP-1 cells. Transfection studies with a reporter construct and subsequent treatment with 15d-PGJ2 demonstrated a dose-dependent inhibition of the TNF-α promoter. Additional studies demonstrated that inhibition of histone deacetylases with trichostatin A (TSA) or overexpression of histone acetyltransferase CBP could overcome 15d-PGJ2-mediated repression of the TNF-α promoter, suggesting that an important mechanism whereby 15d-PGJ2 suppresses a cytokine is through factors that regulate histone modifications. To examine the endogenous TNF-α promoter, chromatin immunoprecipitations (ChIP) were performed. ChIP assays demonstrated that LPS stimulation induced an increase in histone H3 and H4 acetylation at the TNF-α promoter, which was reduced in cells pretreated with 15d-PGJ2. These results highlight the ability of acetylation and deacetylation factors to affect the TNF-α promoter and demonstrate that an additional important mechanism whereby 15d-PGJ2 mediates TNF-α transcriptional repression by altering levels of acetylated histone H3 and H4 at its promoter

The {sup 14}N(p, {gamma}){sup 15}O reaction studied at low and high beam energy

Energy Technology Data Exchange (ETDEWEB)

Marta, Michele

2012-07-01

The Bethe-Weizsaecker cycle consists of a set of nuclear reactions that convert hydrogen into helium and release energy in the stars. It determines the luminosity of low-metal stars at their turn-off from the main-sequence in the Hertzsprung-Russel diagram, so its rate enters the calculation of the globular clusters' age, an independent lower limit on the age of the universe. The cycle contributes less than 1% to our Sun's luminosity, but it produces neutrinos that can in principle be measured on Earth in underground experiments and bring direct information of the physical conditions in the solar core, provided that the nuclear reaction rate is known with sufficient precision. The {sup 14}N(p,{gamma}){sup 15}O reaction is the slowest reaction of the Bethe-Weizsaecker cycle and establishes its rate. Its cross section is the sum of the contributions by capture to different excited levels and to the ground state in {sup 15}O. Recent experiments studied the region of the resonance at E{sub p} = 278 keV. Only one modern data set from an experiment performed in 1987 is available for the high-energy domain. Both energy ranges are needed to constrain the fit of the excitation function in the R-matrix framework and to obtain a reliable extrapolated S-factor at the very low astrophysical energies. The present research work studied the {sup 14}N(p,{gamma}){sup 15}O reaction in the LUNA (Laboratory for Underground Nuclear Astrophysics) underground facility at three proton energies 0.36, 0.38, 0.40MeV, and in Dresden in the energy range E{sub p} = 0.6 - 2MeV. In both cases, an intense proton beam was sent on solid titanium nitride sputtered targets, and the prompt photons emitted from the reaction were detected with germanium detectors. At LUNA, a composite germanium detector was used. This enabled a measurement with dramatically reduced summing corrections with respect to previous studies. The cross sections for capture to the ground state and to the excited states

15N Hyperpolarization of Imidazole-15N2 for Magnetic Resonance pH Sensing via SABRE-SHEATH.

Science.gov (United States)

Shchepin, Roman V; Barskiy, Danila A; Coffey, Aaron M; Theis, Thomas; Shi, Fan; Warren, Warren S; Goodson, Boyd M; Chekmenev, Eduard Y

2016-06-24

15 N nuclear spins of imidazole- 15 N 2 were hyperpolarized using NMR signal amplification by reversible exchange in shield enables alignment transfer to heteronuclei (SABRE-SHEATH). A 15 N NMR signal enhancement of ∼2000-fold at 9.4 T is reported using parahydrogen gas (∼50% para-) and ∼0.1 M imidazole- 15 N 2 in methanol:aqueous buffer (∼1:1). Proton binding to a 15 N site of imidazole occurs at physiological pH (p K a ∼ 7.0), and the binding event changes the 15 N isotropic chemical shift by ∼30 ppm. These properties are ideal for in vivo pH sensing. Additionally, imidazoles have low toxicity and are readily incorporated into a wide range of biomolecules. 15 N-Imidazole SABRE-SHEATH hyperpolarization potentially enables pH sensing on scales ranging from peptide and protein molecules to living organisms.

Decomposition of 14C-15N straw incorporated at three depths in a red-yellow latosol at Pernambuco State, Brazil

International Nuclear Information System (INIS)

Sampaio, E.V.S.; Salcedo, I.H.; Bettany, J.

1990-01-01

The decomposition of 14 C- 15 N labelled straw, incorporated at three depths in a Red-yellow Latosol from the humid, coastal zone of Pernambuco State, Brazil, was measured during two years. The straw was ground, mixed with soil portions and placed in 400-mesh bags and replaced into the original field sites at 10, 30 and 60cm depth. The decomposition was also followed in the laboratory using soil from the superficial layer. Straw carbon losses in the field reached 52% during the first month and about 80% after two years. In the first 4 months mineralization was faster in the superficial layer, with no differences thereafter. In the laboratory, mineralization was slower than in the field, reaching 34 and 50% after one month and two years, respectively. During the first month, most of the soil microbial biomass was apparently formed from straw derived material but the contribution from the straw decrease to 15-30% after two months and to less than 1% after two years. Straw N losses reached 25% in the first month and 40-50% after two years, with significant differences among soil depths in the first six months when losses were higher in the deeper layers. There were no plants to absorb the mineral N which accumulated in the soil to a concentration of up to 32μg/g soil. The contribution of straw N to this mineral N decreased with incubation period but was always less than 12%. The C:N ratio of straw derived material ( 14 C- 15 N) decreased from 22:1 to 8-10:1, at all depths. (author)

Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity.

Science.gov (United States)

Seals, Douglas R; Justice, Jamie N; LaRocca, Thomas J

2016-04-15

Most nations of the world are undergoing rapid and dramatic population ageing, which presents great socio-economic challenges, as well as opportunities, for individuals, families, governments and societies. The prevailing biomedical strategy for reducing the healthcare impact of population ageing has been 'compression of morbidity' and, more recently, to increase healthspan, both of which seek to extend the healthy period of life and delay the development of chronic diseases and disability until a brief period at the end of life. Indeed, a recently established field within biological ageing research, 'geroscience', is focused on healthspan extension. Superimposed on this background are new attitudes and demand for 'optimal longevity' - living long, but with good health and quality of life. A key obstacle to achieving optimal longevity is the progressive decline in physiological function that occurs with ageing, which causes functional limitations (e.g. reduced mobility) and increases the risk of chronic diseases, disability and mortality. Current efforts to increase healthspan centre on slowing the fundamental biological processes of ageing such as inflammation/oxidative stress, increased senescence, mitochondrial dysfunction, impaired proteostasis and reduced stress resistance. We propose that optimization of physiological function throughout the lifespan should be a major emphasis of any contemporary biomedical policy addressing global ageing. Effective strategies should delay, reduce in magnitude or abolish reductions in function with ageing (primary prevention) and/or improve function or slow further declines in older adults with already impaired function (secondary prevention). Healthy lifestyle practices featuring regular physical activity and ideal energy intake/diet composition represent first-line function-preserving strategies, with pharmacological agents, including existing and new pharmaceuticals and novel 'nutraceutical' compounds, serving as potential

Synthesis of [methyl-14C]crotonobetaine from DL-[methyl-14C]carnitine

International Nuclear Information System (INIS)

Loester, H.; Seim, H.

1996-01-01

The causes of carnitine deficiency syndromes are not completely understood, but decomposition of L-carnitine in vivo is likely to be involved. Carnitine is metabolized to γ-butyrobetaine, and crotonobetaine is probably an intermediate in this pathway. To validate experimentally the precursor-product relationship between the three physiologically occuring γ-betaines - L-carnitine, crotonobetaine, γ-butyrobetaine - labelling with stable or radioactive isotopes became necessary. Methyl-labelled carnitine isomers (L(-)-, D(+)- or DL-) or γ-butyrobetaine can be easily synthesized by methylation of 4-amino-3-hydroxybutyric acid isomers or 4-aminobutyric acid, respectively. Because of problems with the 4-aminocrotonic acid, we synthesized labelled crotonbetaine from labelled carnitine. Thus, DL-[methyl- 14 C]carnitine was dehydrated by reaction with concentrated sulfuric acid. After removal of the latter the products were separated and purified by ion exchange chromatography on DOWEX 50 WX8 (200 - 400 mesh) and gradient elution with hydrochloric acid. In addition to the labelled main product [methyl- 14 C]crotonobetaine (yield about 50 %), [methyl- 14 C]glycine betaine and [methyl- 14 C]acetonyl-trimethylammonium (ATMA) were formed. The end products were identified by combined thin layer chromatography/autoradiography and quantified by liquid scintillation counting. (Author)

Galen and the beginnings of Western physiology.

Science.gov (United States)

West, John B

2014-07-15

Galen (129-c. 216 AD) was a key figure in the early development of Western physiology. His teachings incorporated much of the ancient Greek traditions including the work of Hippocrates and Aristotle. Galen himself was a well-educated Greco-Roman physician and physiologist who at one time was a physician to the gladiators in Pergamon. Later he moved to Rome, where he was associated with the Roman emperors Marcus Aurelius and Lucius Verus. The Galenical school was responsible for voluminous writings, many of which are still extant. One emphasis was on the humors of the body, which were believed to be important in disease. Another was the cardiopulmonary system, including the belief that part of the blood from the right ventricle could enter the left through the interventricular septum. An extraordinary feature of these teachings is that they dominated thinking for some 1,300 years and became accepted as dogma by both the State and Church. One of the first anatomists to challenge the Galenical teachings was Andreas Vesalius, who produced a magnificent atlas of human anatomy in 1543. At about the same time Michael Servetus described the pulmonary transit of blood, but he was burned at the stake for heresy. Finally, with William Harvey and others in the first part of the 17th century, the beginnings of modern physiology emerged with an emphasis on hypotheses and experimental data. Nevertheless, vestiges of Galen's teaching survived into the 19th century. Copyright © 2014 the American Physiological Society.

Stable isotope tracers and exercise physiology: past, present and future.

Science.gov (United States)

Wilkinson, Daniel J; Brook, Matthew S; Smith, Kenneth; Atherton, Philip J

2017-05-01

Stable isotope tracers have been invaluable assets in physiological research for over 80 years. The application of substrate-specific stable isotope tracers has permitted exquisite insight into amino acid, fatty-acid and carbohydrate metabolic regulation (i.e. incorporation, flux, and oxidation, in a tissue-specific and whole-body fashion) in health, disease and response to acute and chronic exercise. Yet, despite many breakthroughs, there are limitations to 'substrate-specific' stable isotope tracers, which limit physiological insight, e.g. the need for intravenous infusions and restriction to short-term studies (hours) in controlled laboratory settings. In recent years significant interest has developed in alternative stable isotope tracer techniques that overcome these limitations, in particular deuterium oxide (D 2 O or heavy water). The unique properties of this tracer mean that through oral administration, the turnover and flux through a number of different substrates (muscle proteins, lipids, glucose, DNA (satellite cells)) can be monitored simultaneously and flexibly (hours/weeks/months) without the need for restrictive experimental control. This makes it uniquely suited for the study of 'real world' human exercise physiology (amongst many other applications). Moreover, using D 2 O permits evaluation of turnover of plasma and muscle proteins (e.g. dynamic proteomics) in addition to metabolomics (e.g. fluxomics) to seek molecular underpinnings, e.g. of exercise adaptation. Here, we provide insight into the role of stable isotope tracers, from substrate-specific to novel D 2 O approaches, in facilitating our understanding of metabolism. Further novel potential applications of stable isotope tracers are also discussed in the context of integration with the snowballing field of 'omic' technologies. © 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society.

Sistemas de Alimentação Pós-Desmama de Bezerras de Corte para Acasalamento com 14/15 Meses de Idade Post Weaning Feeding Systems for Beef Heifers to be Bred at 14/15 Months of Age

Directory of Open Access Journals (Sweden)

Marta Gomes da Rocha

2002-07-01

Full Text Available Este trabalho foi conduzido com o objetivo de avaliar o desempenho de bezerras de corte submetidas a sistemas alternativos de alimentação, no primeiro período outono/inverno pós-desmama, por 88 dias, e, após este período, mantidas sobre pastagem melhorada, até o final do seu primeiro acasalamento, com 14-15 meses de idade. Os sistemas utilizados foram: pastagem- pastejo contínuo em pastagem cultivada de azevém (Lolium multiflorum Lam; suplementação- pastejo contínuo em pastagem natural e suplementação energético-protéica; confinamento- confinamento, a céu aberto, com silagem de sorgo + nitrogênio não-protéico (NNP. Após esse período, as bezerras pastejaram em conjunto pastagens naturais melhoradas compostas por azevém, trevo branco (Trifolium repens e cornichão (Lotus corniculatus. Os dados foram coletados em uma Empresa Agropecuária, localizada em Dom Pedrito, RS, em 395 bezerras de corte pertencentes a três grupos genéticos: Hereford; 3/4 Hereford-1/4 Nelore; 5/8 Hereford-3/8 Nelore. Foram tomados registros de peso vivo (PV, ganho de peso médio diário (GMD e condição corporal (CC. As bezerras mostraram comportamento semelhante quanto ao PV e GMD. A CC foi maior nos animais do grupo confinamento. No início e final da estação de acasalamento, novilhas alimentadas exclusivamente em pastagens tiveram maior PV e CC do que novilhas dos grupos suplementação e confinamento, que não diferiram entre si.The experiment evaluated the performance of beef heifers submitted to three alternatives of autumn-winter feeding systems, during 88 days, and after this period on improved pastures all together until the end of theirs first mating season, with 14-15 months of age. The systems were: Pasture- continuous grazing on cultivated annual ryegrass (L. multiflorum Lam; supplementation- continuous grazing on natural pasture plus energy and protein supplementation; feedlot - feedlot, with sorghum silage plus non- proteic nitrogen

Physiological responses of the seagrass Posidonia oceanica as indicators of fish farm impact

International Nuclear Information System (INIS)

Perez, Marta; Garcia, Tania; Invers, Olga; Ruiz, Juan Manuel

2008-01-01

The development of aquaculture along the Mediterranean coastline degrades the marine environment, in particular Posidonia oceanica meadows, which, in extreme cases, show high mortality. Here we studied the effects of organic matter and nutrient input from the effluents of three fish farms, located along the Mediterranean coast, on P. oceanica physiology. For this purpose, we measured physiological variables such as total nitrogen (N) content, free amino acid (FAA) concentration and composition, N stable isotope ratio (δ 15 N), total phosphorus (P) content and total non-structural carbohydrate (TNC) content in plant tissues and epiphytes affected by organic discharges (highly impacted stations: HI, and less impacted stations: LI) and compared these results with those obtained in references sites (control stations: C). For all the descriptors analyzed in P. oceanica epiphytes, the values recorded in the vicinity of cages were, in general, much higher than those in C. Leaves did not respond consistently in any case. Total N content and δ 15 N in epiphytes together with the total P content in rhizomes and epiphytes were the physiological descriptors that showed the most consistent responses to fish farm effluents. On the basis of these observations, we conclude that fish farm activities strongly affect the physiological parameters of nearby P. oceanica meadows. We propose that changes in these physiological parameters may be useful indicators of marine environmental degradation in studies that monitor the effects of fish farming

Physiological responses of the seagrass Posidonia oceanica as indicators of fish farm impact

Energy Technology Data Exchange (ETDEWEB)

Perez, Marta [Departament d' Ecologia, Universitat de Barcelona Avda. Diagonal 645, 08028 Barcelona (Spain); Garcia, Tania [Departament d' Ecologia, Universitat de Barcelona Avda. Diagonal 645, 08028 Barcelona (Spain)], E-mail: irulagun@hotmail.com; Invers, Olga [Departament d' Ecologia, Universitat de Barcelona Avda. Diagonal 645, 08028 Barcelona (Spain); Ruiz, Juan Manuel [Instituto Espanol de Oceanografia C/Varadero 1, 30740 San Pedro del Pinatar, Murcia (Spain)

2008-05-15

The development of aquaculture along the Mediterranean coastline degrades the marine environment, in particular Posidonia oceanica meadows, which, in extreme cases, show high mortality. Here we studied the effects of organic matter and nutrient input from the effluents of three fish farms, located along the Mediterranean coast, on P. oceanica physiology. For this purpose, we measured physiological variables such as total nitrogen (N) content, free amino acid (FAA) concentration and composition, N stable isotope ratio ({delta}{sup 15}N), total phosphorus (P) content and total non-structural carbohydrate (TNC) content in plant tissues and epiphytes affected by organic discharges (highly impacted stations: HI, and less impacted stations: LI) and compared these results with those obtained in references sites (control stations: C). For all the descriptors analyzed in P. oceanica epiphytes, the values recorded in the vicinity of cages were, in general, much higher than those in C. Leaves did not respond consistently in any case. Total N content and {delta}{sup 15}N in epiphytes together with the total P content in rhizomes and epiphytes were the physiological descriptors that showed the most consistent responses to fish farm effluents. On the basis of these observations, we conclude that fish farm activities strongly affect the physiological parameters of nearby P. oceanica meadows. We propose that changes in these physiological parameters may be useful indicators of marine environmental degradation in studies that monitor the effects of fish farming.

Physiological adjustment to salt stress in Jatropha curcas is associated with accumulation of salt ions, transport and selectivity of K+, osmotic adjustment and K+/Na+ homeostasis.

Science.gov (United States)

Silva, E N; Silveira, J A G; Rodrigues, C R F; Viégas, R A

2015-09-01

This study assessed the capacity of Jatropha curcas to physiologically adjust to salinity. Seedlings were exposed to increasing NaCl concentrations (25, 50, 75 and 100 mm) for 15 days. Treatment without NaCl was adopted as control. Shoot dry weight was strongly reduced by NaCl, reaching values of 35% to 65% with 25 to 100 mm NaCl. The shoot/root ratio was only affected with 100 mm NaCl. Relative water content (RWC) increased only with 100 mm NaCl, while electrolyte leakage (EL) was much enhanced with 50 mm NaCl. The Na(+) transport rate to the shoot was more affected with 50 and 100 mm NaCl. In parallel, Cl(-) transport rate increased with 75 and 100 mm NaCl, while K(+) transport rate fell from 50 mm to 100 mm NaCl. In roots, Na(+) and Cl(-) transport rates fell slightly only in 50 mm (to Na(+)) and 50 and 100 mm (to Cl(-)) NaCl, while K(+) transport rate fell significantly with increasing NaCl. In general, our data demonstrate that J. curcas seedlings present changes in key physiological processes that allow this species to adjust to salinity. These responses are related to accumulation of Na(+) and Cl(-) in leaves and roots, K(+)/Na(+) homeostasis, transport of K(+) and selectivity (K-Na) in roots, and accumulation of organic solutes contributing to osmotic adjustment of the species. © 2015 German Botanical Society and The Royal Botanical Society of the Netherlands.

Presbypropria: the effects of physiological ageing on proprioceptive control.

Science.gov (United States)

Boisgontier, Matthieu P; Olivier, Isabelle; Chenu, Olivier; Nougier, Vincent

2012-10-01

Several changes in the human sensory systems, like presbycusis or presbyopia, are well-known to occur with physiological ageing. A similar change is likely to occur in proprioception, too, but there are strong and unexplained discrepancies in the literature. It was proposed that assessment of the attentional cost of proprioceptive control could provide information able to unify these previous studies. To this aim, 15 young adults and 15 older adults performed a position matching task in single and dual-task paradigms with different difficulty levels of the secondary task (congruent and incongruent Stroop-type tasks) to assess presumed age-related deficits in proprioceptive control. Results showed that proprioceptive control was as accurate and as consistent in older as in young adults for a single proprioceptive task. However, performing a secondary cognitive task and increasing the difficulty of this secondary task evidenced both a decreased matching performance and/or an increased attentional cost of proprioceptive control in older adults as compared to young ones. These results advocated for an impaired proprioception in physiological ageing.

Transcriptional effects of 1,25 dihydroxyvitamin D3 physiological and supra-physiological concentrations in breast cancer organotypic culture

International Nuclear Information System (INIS)

Milani, Cintia; Góes, João Carlos Guedes Sampaio; Nonogaki, Suely; Tamura, Rodrigo Esaki; Folgueira, Maria Aparecida Azevedo Koike; Katayama, Maria Lucia Hirata; Lyra, Eduardo Carneiro de; Welsh, JoEllen; Campos, Laura Tojeiro; Brentani, M Mitzi; Maciel, Maria do Socorro; Roela, Rosimeire Aparecida; Valle, Paulo Roberto del

2013-01-01

Vitamin D transcriptional effects were linked to tumor growth control, however, the hormone targets were determined in cell cultures exposed to supra physiological concentrations of 1,25(OH) 2 D 3 (50-100nM). Our aim was to evaluate the transcriptional effects of 1,25(OH) 2 D 3 in a more physiological model of breast cancer, consisting of fresh tumor slices exposed to 1,25(OH) 2 D 3 at concentrations that can be attained in vivo. Tumor samples from post-menopausal breast cancer patients were sliced and cultured for 24 hours with or without 1,25(OH) 2 D 3 0.5nM or 100nM. Gene expression was analyzed by microarray (SAM paired analysis, FDR≤0.1) or RT-qPCR (p≤0.05, Friedman/Wilcoxon test). Expression of candidate genes was then evaluated in mammary epithelial/breast cancer lineages and cancer associated fibroblasts (CAFs), exposed or not to 1,25(OH) 2 D 3 0.5nM, using RT-qPCR, western blot or immunocytochemistry. 1,25(OH) 2 D 3 0.5nM or 100nM effects were evaluated in five tumor samples by microarray and seven and 136 genes, respectively, were up-regulated. There was an enrichment of genes containing transcription factor binding sites for the vitamin D receptor (VDR) in samples exposed to 1,25(OH) 2 D 3 near physiological concentration. Genes up-modulated by both 1,25(OH) 2 D 3 concentrations were CYP24A1, DPP4, CA2, EFTUD1, TKTL1, KCNK3. Expression of candidate genes was subsequently evaluated in another 16 samples by RT-qPCR and up-regulation of CYP24A1, DPP4 and CA2 by 1,25(OH) 2 D 3 was confirmed. To evaluate whether the transcripitonal targets of 1,25(OH) 2 D 3 0.5nM were restricted to the epithelial or stromal compartments, gene expression was examined in HB4A, C5.4, SKBR3, MDA-MB231, MCF-7 lineages and CAFs, using RT-qPCR. In epithelial cells, there was a clear induction of CYP24A1, CA2, CD14 and IL1RL1. In fibroblasts, in addition to CYP24A1 induction, there was a trend towards up-regulation of CA2, IL1RL1, and DPP4. A higher protein expression of CD14 in

Quantitative Circulatory Physiology: an integrative mathematical model of human physiology for medical education.

Science.gov (United States)

Abram, Sean R; Hodnett, Benjamin L; Summers, Richard L; Coleman, Thomas G; Hester, Robert L

2007-06-01

We have developed Quantitative Circulatory Physiology (QCP), a mathematical model of integrative human physiology containing over 4,000 variables of biological interactions. This model provides a teaching environment that mimics clinical problems encountered in the practice of medicine. The model structure is based on documented physiological responses within peer-reviewed literature and serves as a dynamic compendium of physiological knowledge. The model is solved using a desktop, Windows-based program, allowing students to calculate time-dependent solutions and interactively alter over 750 parameters that modify physiological function. The model can be used to understand proposed mechanisms of physiological function and the interactions among physiological variables that may not be otherwise intuitively evident. In addition to open-ended or unstructured simulations, we have developed 30 physiological simulations, including heart failure, anemia, diabetes, and hemorrhage. Additional stimulations include 29 patients in which students are challenged to diagnose the pathophysiology based on their understanding of integrative physiology. In summary, QCP allows students to examine, integrate, and understand a host of physiological factors without causing harm to patients. This model is available as a free download for Windows computers at http://physiology.umc.edu/themodelingworkshop.

Effectiveness of inquiry-based learning in an undergraduate exercise physiology course.

Science.gov (United States)

Nybo, Lars; May, Michael

2015-06-01

The present study was conducted to investigate the effects of changing a laboratory physiology course for undergraduate students from a traditional step-by-step guided structure to an inquiry-based approach. With this aim in mind, quantitative and qualitative evaluations of learning outcomes (individual subject-specific tests and group interviews) were performed for a laboratory course in cardiorespiratory exercise physiology that was conducted in one year with a traditional step-by-step guided manual (traditional course) and the next year completed with an inquiry-based structure (I-based course). The I-based course was a guided inquiry course where students had to design the experimental protocol and conduct their own study on the basis of certain predefined criteria (i.e., they should evaluate respiratory responses to submaximal and maximal exercise and provide indirect and direct measures of aerobic exercise capacity). The results indicated that the overall time spent on the experimental course as well as self-evaluated learning outcomes were similar across groups. However, students in the I-based course used more time in preparation (102 ± 5 min) than students in the traditional course (42 ± 3 min, P traditional course. Furthermore, students in the I-based course achieved a higher (P traditional course (31 ± 4%). Although students were unfamiliar with cardiorespiratory exercise physiology and the experimental methods before the course, it appears that an inquiry-based approach rather than one that provides students with step-by-step instructions may benefit learning outcomes in a laboratory physiology course. Copyright © 2015 The American Physiological Society.

Effective mass of the four-flux composite fermion at {nu}=1/4

Energy Technology Data Exchange (ETDEWEB)

Pan, W. [Princeton University, Princeton, New Jersey 08544 (United States); National High Magnetic Field Laboratory, Tallahassee, Florida 32310 (United States); Stormer, H. L. [Lucent Technologies, Bell Laboratories, Murray Hill, New Jersey 07974 (United States); Department of Physics and Department of Applied Physics, Columbia University, New York, New York 10027 (United States); Tsui, D. C. [Princeton University, Princeton, New Jersey 08544 (United States); Pfeiffer, L. N. [Lucent Technologies, Bell Laboratories, Murray Hill, New Jersey 07974 (United States); Baldwin, K. W. [Lucent Technologies, Bell Laboratories, Murray Hill, New Jersey 07974 (United States); West, K. W. [Lucent Technologies, Bell Laboratories, Murray Hill, New Jersey 07974 (United States)

2000-02-15

We have measured the effective mass (m{sup *}) of the four flux composite fermion at Landau-level filling factor {nu}=1/4 ({sup 4}CF), using the activation energy gaps at the fractional quantum Hall effect states {nu}=2/7, 3/11, and 4/15 and the temperature dependence of the Shubnikov-de Haas (SdH) oscillations around {nu}=1/4. We find that the energy gaps show a linear dependence on the effective magnetic field B{sub eff} ({identical_to}B-B{sub {nu}}{sub =1/4}), and from this linear dependence we obtain m{sup *}=1.0m{sub e} and a disorder broadening {gamma}{approx}1 K for a sample of density n=0.87x10{sup 11} cm{sup -2}. The m{sup *} deduced from the temperature dependence of the SdH effect shows large differences for {nu}>1/4 and {nu}<1/4. For {nu}>1/4, m{sup *}{approx}1.0m{sub e}. It scales as {radical}(B{sub {nu}}) with the mass derived from the data around {nu}=1/2 and shows an increase in m{sup *} as {nu}{yields}1/4, resembling the findings around {nu}=1/2. For {nu}<1/4, m{sup *} increases rapidly with increasing B{sub eff} and can be described by m{sup *}/m{sub e}=-3.3+5.7B{sub eff}. This anomalous dependence on B{sub eff} is precursory to the formation of the insulating phase at still lower filling. (c) 2000 The American Physical Society.

Mass Society

DEFF Research Database (Denmark)

Borch, Christian

2017-01-01

the negative features usually ascribed by late nineteenth-century crowd psychology to spontaneous crowds, and attributes these to the entire social fabric. However, in contrast to crowd psychology, theorists of mass society often place greater emphasis on how capitalism, technological advances, or demographic......Mass society is a societal diagnosis that emphasizes – usually in a pejorative, modernity critical manner – a series of traits allegedly associated with modern society, such as the leveling of individuality, moral decay, alienation, and isolation. As such, the notion of mass society generalizes...... developments condition such negative features, and some theorists argue that mass society produces a propensity to totalitarianism. Discussions of mass society culminated in the early and mid-twentieth century....

Patients receiving anti-TNF therapies experience clinically important improvements in RA-related fatigue: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis.

Science.gov (United States)

Druce, Katie L; Jones, Gareth T; Macfarlane, Gary J; Basu, Neil

2015-06-01

Pro-inflammatory cytokines such as TNF-α are important in the pathogenesis of fatigue in conditions such as RA. This study aimed to determine whether fatigue improved in a cohort of RA patients with clinically relevant fatigue commencing anti-TNF-α therapy and, if so, to identify predictors of improvement. Participants recruited to a long-term observational cohort study (the British Society for Rheumatology Biologics Register for RA) provided information on fatigue using the 36-item Short Form Health Survey (SF-36) vitality subscale. The prevalence of severe baseline fatigue (SF-36 vitality ≤12.5) was calculated and improvements, considered as (i) absolute values and (ii) improvement from severe to non-severe fatigue (SF-36 vitality >12.5), were examined 6 months subsequently. A comprehensive set of putative predictors of fatigue improvement were evaluated using multivariable logistic regression. In 6835 participants the prevalence of severe baseline fatigue was 38.8%. Of those with severe fatigue, 70% reported clinically relevant improvement and 66% moved to the non-severe fatigue category (i.e. improvers). The mean change for improvers was three times the minimum clinically important difference for improvement (33.0 U). Independent baseline predictors of improvement were female sex [odds ratio (OR) 1.3 (95% CI 1.1, 1.7)], not being unemployed due to ill health [OR 1.5 (95% CI 1.2, 1.7)], low disability [OR 1.2 (95% CI 1.001, 1.5)], seropositivity [OR 1.2 (95% CI 0.98, 1.4)], not using steroids [OR 1.2 (95% CI 1.03, 1.5)], no history of hypertension [OR 1.4 (95% CI 1.1, 1.6)] or depression [OR 1.3 (95% CI 1.1, 1.5)] and good mental health [SF-36 mental health subscale >35; OR 1.4 (95% CI 1.2, 1.7)]. Fatigued RA patients reported substantial improvement in their fatigue after commencing anti-TNF-α therapy. Further, a number of clinical and psychosocial baseline factors identified those most likely to improve, supporting future stratified approaches to RA

PHYSIOLOGICAL PROFILE OF SENIOR AND JUNIOR ENGLAND INTERNATIONAL AMATEUR BOXERS

Directory of Open Access Journals (Sweden)

Marcus S. Smith

2006-07-01

Full Text Available Despite worldwide popularity of amateur boxing, research focussed on the physiological demands of the sport is limited. The physiological profile of Senior and Junior England international amateur boxers is presented. A gradual (8 to 21-days and rapid (0 to 7-days phase of body weight reduction was evident with 2.2 ± 0.3 % of the 7.0 ± 0. 8 % weight loss occurring over the final 24-hours. An increase in body weight >4% was observed following a recovery period. High urine osmolality values (> 1000 mOsm·kg-1 were recorded during training and competition. High post-competition blood lactate values (>13.5 mmol·l-1 highlighted the need for a well-developed anaerobic capacity and the importance of not entering the ring in a glycogen depleted state. The aerobic challenge of competition was demonstrated by maximum heart rate values being recorded during 'Open' sparring. Mean body fat values of 9-10% were similar to those reported for other weight classified athletes. Normal resting values were reported for hematocrit (Senior 48 ± 2 % and Junior 45 ± 2 %, haemoglobin (Senior 14.7 ± 1.0 g·dl-1 and Junior 14.5 ± 0.8 g·dl-1, bilirubin (Senior 15.3 ± 6.2 µmol·l-1-1 and ferritin (Senior 63.3 ± 45.7 ng·ml-1. No symptoms associated with asthma or exercise-induced asthma was evident. A well- developed aerobic capacity was reflected in the Senior VO2max value of 63.8 ± 4.8 ml·kg-1·min-1. Senior lead hand straight punching force (head 1722 ± 700 N and body 1682 ± 636 N was lower than the straight rear hand (head 2643 ± 1273 N and body 2646 ± 1083 N, lead hook (head 2412 ± 813 N and body 2414 ± 718 N and rear hook (head 2588 ± 1040 N and body 2555 ± 926 N. It was concluded that amateur boxing performance is dependent on the interplay between anaerobic and aerobic energy systems. Current weight making methods may lead to impaired substrate availability, leading to reduced competitive performance and an increased risk to a boxers health

Proceedings of the Korean Radioactive Waste Society Spring 2010

International Nuclear Information System (INIS)

2010-01-01

This proceedings contains articles of the Korean Radioactive Waste Society Spring 2010. It was held on May 13-14, 2010 in Yesan, Korea. The main topics are as follows: Radioactive wastes policy and decontamination and decommissioning, Radioactive waste treatment, Radioactive waste disposal and site selection, Spent fuel and fuel cycle and Radiation safety and environment. (Yi, J. H.)

Maternal physiological dysregulation while parenting poses risk for infant attachment disorganization and behavior problems.

Science.gov (United States)

Leerkes, Esther M; Su, Jinni; Calkins, Susan D; O'Brien, Marion; Supple, Andrew J

2017-02-01

The extent to which indices of maternal physiological arousal (skin conductance augmentation) and regulation (vagal withdrawal) while parenting predict infant attachment disorganization and behavior problems directly or indirectly via maternal sensitivity was examined in a sample of 259 mothers and their infants. Two covariates, maternal self-reported emotional risk and Adult Attachment Interview attachment coherence were assessed prenatally. Mothers' physiological arousal and regulation were measured during parenting tasks when infants were 6 months old. Maternal sensitivity was observed during distress-eliciting tasks when infants were 6 and 14 months old, and an average sensitivity score was calculated. Attachment disorganization was observed during the Strange Situation when infants were 14 months old, and mothers reported on infants' behavior problems when infants were 27 months old. Over and above covariates, mothers' arousal and regulation while parenting interacted to predict infant attachment disorganization and behavior problems such that maternal arousal was associated with higher attachment disorganization and behavior problems when maternal regulation was low but not when maternal regulation was high. This effect was direct and not explained by maternal sensitivity. The results suggest that maternal physiological dysregulation while parenting places infants at risk for psychopathology.

Physiological and psychological assessment of sound

Science.gov (United States)

Yanagihashi, R.; Ohira, Masayoshi; Kimura, Teiji; Fujiwara, Takayuki

The psycho-physiological effects of several sound stimulations were investigated to evaluate the relationship between a psychological parameter, such as subjective perception, and a physiological parameter, such as the heart rate variability (HRV). Eight female students aged 21-22 years old were tested. Electrocardiogram (ECG) and the movement of the chest-wall for estimating respiratory rate were recorded during three different sound stimulations; (1) music provided by a synthesizer (condition A); (2) birds twitters (condition B); and (3) mechanical sounds (condition C). The percentage power of the low-frequency (LF; 0.05<=0.15 Hz) and high-frequency (HF; 0.15<=0.40 Hz) components in the HRV (LF%, HF%) were assessed by a frequency analysis of time-series data for 5 min obtained from R-R intervals in the ECG. Quantitative assessment of subjective perception was also described by a visual analog scale (VAS). The HF% and VAS value for comfort in C were significantly lower than in either A and/or B. The respiratory rate and VAS value for awakening in C were significantly higher than in A and/or B. There was a significant correlation between the HF% and the value of the VAS, and between the respiratory rate and the value of the VAS. These results indicate that mechanical sounds similar to C inhibit the para-sympathetic nervous system and promote a feeling that is unpleasant but alert, also suggesting that the HRV reflects subjective perception.

Validation of the AVITA BPM15S wrist blood pressure monitor for home blood pressure monitoring according to the European Society of Hypertension International Protocol revision 2010.

Science.gov (United States)

Kang, Yuan-Yuan; Zeng, Wei-Fang; Zhang, Lu; Li, Yan; Wang, Ji-Guang

2014-06-01

The present study aimed to evaluate the accuracy of the automated oscillometric wrist blood pressure monitor AVITA BPM15S for home blood pressure monitoring according to the International Protocol revision 2010 of the European Society of Hypertension. Systolic and diastolic blood pressures were sequentially measured in 33 Chinese adults (15 women, mean age 51 years) using a mercury sphygmomanometer (two observers) and the AVITA BPM15S device (one supervisor). Ninety-nine pairs of comparisons were obtained from 33 participants for judgments in two parts with three grading phases. The AVITA BPM15S device achieved the targets in part 1 of the validation study. The number of absolute differences between the device and observers within 5, 10, and 15 mmHg were 85/99, 94/99, and 98/99, respectively, for systolic blood pressure, and 82/99, 96/99, and 98/99, respectively, for diastolic blood pressure. The device also achieved the criteria in part 2 of the validation study. Thirty-two and 28 participants for systolic and diastolic blood pressure, respectively, had at least two of the three device-observer differences within 5 mmHg (required ≥ 24). No participant had all of the three device-observer comparisons greater than 5 mmHg for systolic or diastolic blood pressure. The AVITA wrist blood pressure monitor BPM15S fulfilled the requirements of the International Protocol revision 2010 and hence can be recommended for home use in an adult population.

Size, physiological quality, and green seed occurrence influenced by seeding rate in soybeans

Directory of Open Access Journals (Sweden)

André Sampaio Ferreira

2017-05-01

Full Text Available The seeding rate influences the intraspecific competition, which might affect the development and quality of seeds in soybean. However, the impact of seeding rate on the physical and physiological qualities of soybean seeds needs to be better elucidated. This study aimed to evaluate the effects of soybean plant density on the seed size as well as the effects of the interaction between the plant density and seed size on the seed mass, green seed occurence, and physiological seed quality. The experiments were carried out in the growing seasons of the years 2013/14 and 2014/15 in a Latossolo Vermelho distroférrico, under a randomized complete block design, using the NK 7059 RR cultivar with six replications. Four plant densities (150, 300, 440, and 560 thousand viable seeds ha–1 were evaluated. After the classification of seeds into four sizes, using a set of sieves, a 4 ×4 factorial scheme was used for the statistical analysis of the four plant densities and four seed sizes. The seed samples were evaluated for the seed mass, green seed percentage, germination, and vigor. Under thermal and water stress during seed development, an increase in the seeding rate led to a reduction in the green seed occurrence and an increase in the seed size and mass. However, in the absence of thermal and water stress, the seed size and mass were not altered by the seeding rate and, there was no occurrence of green seeds.

Behavioral and emotional problems reported by parents of children ages 6 to 16 in 31 societies

DEFF Research Database (Denmark)

Rescorla, L.; Achenbach, T.; Ivanova, M.Y.

2007-01-01

This study compared parents' ratings of behavioral and emotional problems on the Child Behavior Checklist (Achenbach, 1991; Achenbach & Rescorla, 2001) for general population samples of children ages 6 to 16 from 31 societies (N = 55,508). Effect sizes for society ranged from .03 to .14. Effect s...

Physiological, Nutritional and Performance Profiles of Brazilian Jiu-Jitsu Athletes

Directory of Open Access Journals (Sweden)

Andreato Leonardo V

2016-12-01

Full Text Available This study analysed the physiological, nutritional and performance profiles of athletes practicing Brazilian jiu-jitsu. To this end, 15 athletes that practiced Brazilian jiu-jitsu (aged: 28 ± 5 years; 8 brown belts and 7 black belts; training experience: 11 ± 4 years underwent anthropometric measurements (body composition and somatotype, dietary evaluation (24 h recall and physical fitness tests (movement time, dynamometer handgrip, kimono grip strength, vertical jump and sit-and-reach tests. The athletes had 12.7 ± 4.8% of body fat, 59.2 ± 5.0% of muscle mass and their somatotype was dominated by the mesomorphic component (5.3 ± 2.0, followed by endomorphic (3.7 ± 1.5 and ectomorphic (1.4 ± 0.9 components. Nutritional assessment suggested a diet consisting of 54 ± 7% of carbohydrates, 19 ± 4% of protein and 27 ± 6% of lipids. Movement time on the handgrip tests was 0.42 ± 0.05 s, for handgrip strength, 53 ± 7 kgf was found for the dominant hand and 50 ± 9 kgf for the non-dominant hand. For the countermovement jump, the jiu-jitsu athletes reached 41 ± 5 cm. Athletes remained 30 ± 14 s in the maximum static suspension test gripping a kimono, and reached 27 ± 8 cm in the sit-and-reach test. Overall the sample presented average levels of body fat, elevated muscle mass and a predominantly mesomorphic somatotype. Diet was generally poor, with low carbohydrate intake, high protein intake and adequate lipid intake. Maximum isometric handgrip strength was consistent with observations of other athletes in this sport discipline. However, the performance in the maximum static suspension test gripping a kimono was lower than in other Brazilian jiu-jitsu athletes. Movement time was comparable and lower body muscle power was worse compared to athletes in similar sports. Additionally, flexibility was rated as poor.

Physiological, Nutritional and Performance Profiles of Brazilian Jiu-Jitsu Athletes.

Science.gov (United States)

Andreato, Leonardo V; Santos, Jonatas Fs; Esteves, João Vdc; Panissa, Valeria Lg; Julio, Ursula F; Franchini, Emerson

2016-12-01

This study analysed the physiological, nutritional and performance profiles of athletes practicing Brazilian jiu-jitsu. To this end, 15 athletes that practiced Brazilian jiu-jitsu (aged: 28 ± 5 years; 8 brown belts and 7 black belts; training experience: 11 ± 4 years) underwent anthropometric measurements (body composition and somatotype), dietary evaluation (24 h recall) and physical fitness tests (movement time, dynamometer handgrip, kimono grip strength, vertical jump and sit-and-reach tests). The athletes had 12.7 ± 4.8% of body fat, 59.2 ± 5.0% of muscle mass and their somatotype was dominated by the mesomorphic component (5.3 ± 2.0), followed by endomorphic (3.7 ± 1.5) and ectomorphic (1.4 ± 0.9) components. Nutritional assessment suggested a diet consisting of 54 ± 7% of carbohydrates, 19 ± 4% of protein and 27 ± 6% of lipids. Movement time on the handgrip tests was 0.42 ± 0.05 s, for handgrip strength, 53 ± 7 kgf was found for the dominant hand and 50 ± 9 kgf for the non-dominant hand. For the countermovement jump, the jiu-jitsu athletes reached 41 ± 5 cm. Athletes remained 30 ± 14 s in the maximum static suspension test gripping a kimono, and reached 27 ± 8 cm in the sit-and-reach test. Overall the sample presented average levels of body fat, elevated muscle mass and a predominantly mesomorphic somatotype. Diet was generally poor, with low carbohydrate intake, high protein intake and adequate lipid intake. Maximum isometric handgrip strength was consistent with observations of other athletes in this sport discipline. However, the performance in the maximum static suspension test gripping a kimono was lower than in other Brazilian jiu-jitsu athletes. Movement time was comparable and lower body muscle power was worse compared to athletes in similar sports. Additionally, flexibility was rated as poor.

Effect of gamma irradiation on lifespan and offspring physiology of male drosophila melanogaster

International Nuclear Information System (INIS)

Hou Jiangyu; Gu Wei; Jiang Fangping; Han Hetong

2010-01-01

This study aimed to investigate the effects of γ-rays irradiation on adult longevity and physiological changes in F 1 generation.Male Drosophila melanogaster at 1 ∼ 2 days old were irradiated by γ-rays with doses of 5, 10, 15 and 30 Gy. In all experimental groups, mean lifespan, maximum lifespan and 90% of lethaldeath irradiated flies were reduced(at P 1 generation of irradiated group, body weight increased, but the capacity of physiological stress declined. (authors)

Use of reversed-phase gel partition chromatography for the purification of chemically synthesized (5,6,8,9,11,12,14,15(n)) octadeuterium- and octatritium-labelled arachidonic acid

Energy Technology Data Exchange (ETDEWEB)

Wollard, P M; Lascelles, P T [Department of Chemical Pathology, Institute of Neurology, London, Great Britain; Hensby, C N [Hammersmith Hospital, London (UK). Postgraduate Medical School

1978-12-11

The development of a method is described for the preparation and purification of (5,6,8,9,11,12,14,15(n)-/sup 2/H)arachidonic acid (/sup 2/H/sub 8/-AA). The /sup 2/H/sub 8/-AA was chemically synthesised by the selective reduction of 5,8,11,14-eiconsatetraynoic acid (ETYA) with deuterium gas. Using reversed-phase partition chromatography on a Lipidex 5000 column support, it was shown that: (1) The reaction products could readily be separated from each other to yield /sup 2/H/sub 8/-AA of greater than 98% mass purity by gas chromatography. (2) Closely related C20 cis-ethylenic fatty acids differing only in the degree of unsaturation are efficiently separated. The resolution increases exponentially on saturation of double bonds. (3) Commercially available (5,6,8,9,11,12,14,15(n))octatritium-labelled arachidonic acid (/sup 3/H/sub 8/-AA) was readily purified. Both (/sup 3/H/sub 8/)- and (1-/sup 14/C)arachidonic acid (/sup 14/C-AA) co-chromatographed with /sup 2/H/sub 8/-AA. (4) The mass spectra of the methyl ester and trimethylsilyl ester of the purified /sup 2/H/sub 8/-AA showed molecular ions at m/e 326 and 384, respectively.

The physiology of the normal human breast: an exploratory study.

Science.gov (United States)

Mills, Dixie; Gordon, Eva J; Casano, Ashley; Lahti, Sarah Michelle; Nguyen, Tinh; Preston, Alex; Tondre, Julie; Wu, Kuan; Yanase, Tiffany; Chan, Henry; Chia, David; Esfandiari, Mahtash; Himmel, Tiffany; Love, Susan M

2011-12-01

The physiology of the nonlactating human breast likely plays a key role in factors that contribute to the etiology of breast cancer and other breast conditions. Although there has been extensive research into the physiology of lactation, few reports explore the physiology of the resting mammary gland, including mechanisms by which compounds such as hormones, drugs, and potential carcinogens enter the breast ducts. The purpose of this study was to explore transport of exogenous drugs into ductal fluid in nonlactating women and determine if their concentrations in the fluid are similar to those observed in the breast milk of lactating women. We selected two compounds that have been well characterized during lactation, caffeine and cimetidine. Caffeine passively diffuses into breast milk, but cimetidine is actively transported and concentrated in breast milk. After ingestion of caffeine and cimetidine, 14 nonlactating subjects had blood drawn and underwent ductal lavage at five time points over 12 h to measure drug levels in the fluid and blood. The concentrations of both caffeine and cimetidine in lavage fluid were substantially less than those observed in breast milk. Our results support recent evidence that the cimetidine transporter is not expressed in the nonlactating mammary gland, and highlight intriguing differences in the physiology and molecular transport of the lactating and nonlactating breast. The findings of this exploratory study warrant further exploration into the physiology of the nonlactating mammary gland to elucidate factors involved in disease initiation and progression.

15 CFR 14.25 - Revision of budget and program plans.

Science.gov (United States)

2010-01-01

... ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER EDUCATION, HOSPITALS, OTHER NON-PROFIT, AND COMMERCIAL ORGANIZATIONS Post-Award Requirements Financial and Program Management § 14.25 Revision of budget and program plans. (a) The budget plan is the financial expression of the project or...

Foundations of Intonational Meaning: Anatomical and Physiological Factors.

Science.gov (United States)

Gussenhoven, Carlos

2016-04-01

Like non-verbal communication, paralinguistic communication is rooted in anatomical and physiological factors. Paralinguistic form-meaning relations arise from the way these affect speech production, with some fine-tuning by the cultural and linguistic context. The effects have been classified as "biological codes," following the terminological lead of John Ohala's Frequency Code. Intonational morphemes, though arguably non-arbitrary in principle, are in fact heavily biased toward these paralinguistic meanings. Paralinguistic and linguistic meanings for four biological codes are illustrated. In addition to the Frequency Code, the Effort Code, and the Respiratory Code, the Sirenic Code is introduced here, which is based on the use of whispery phonation, widely seen as being responsible for the signaling and perception of feminine attractiveness and sometimes used to express interrogativity in language. In the context of the evolution of language, the relations between physiological conditions and the resulting paralinguistic and linguistic meanings will need to be clarified. Copyright © 2016 The Authors. Topics in Cognitive Science published by Wiley Periodicals, Inc. on behalf of Cognitive Science Society.

Exploring student preferences with a Q-sort: the development of an individualized renal physiology curriculum.

Science.gov (United States)

Roberts, John K; Hargett, Charles W; Nagler, Alisa; Jakoi, Emma; Lehrich, Ruediger W

2015-09-01

Medical education reform is underway, but the optimal course for change has yet to be seen. While planning for the redesign of a renal physiology course at the Duke School of Medicine, the authors used a Q-sort survey to assess students' attitudes and learning preferences to inform curricular change. The authors invited first-year medical students at the Duke School of Medicine to take a Q-sort survey on the first day of renal physiology. Students prioritized statements related to their understanding of renal physiology, learning preferences, preferred course characteristics, perceived clinical relevance of renal physiology, and interest in nephrology as a career. By-person factor analysis was performed using the centroid method. Three dominant factors were strongly defined by learning preferences: "readers" prefer using notes, a textbook, and avoid lectures; "social-auditory learners" prefer attending lectures, interactivity, and working with peers; and "visual learners" prefer studying images, diagrams, and viewing materials online. A smaller, fourth factor represented a small group of students with a strong predisposition against renal physiology and nephrology. In conclusion, the Q-sort survey identified and then described in detail the dominant viewpoints of our students. Learning style preferences better classified first-year students rather than any of the other domains. A more individualized curriculum would simultaneously cater to the different types of learners in the classroom. Copyright © 2015 The American Physiological Society.

15-deoxy-δ12,14-prostaglandin j2 inhibits osteolytic breast cancer bone metastasis and estrogen deficiency-induced bone loss.

Directory of Open Access Journals (Sweden)

Ki Rim Kim

Full Text Available Breast cancer is the major cause of cancer death in women worldwide. The most common site of metastasis is bone. Bone metastases obstruct the normal bone remodeling process and aberrantly enhance osteoclast-mediated bone resorption, which results in osteolytic lesions. 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2 is an endogenous ligand of peroxisome proliferator-activated receptor gamma (PPARγ that has anti-inflammatory and antitumor activity at micromolar concentrations through PPARγ-dependent and/or PPARγ-independent pathways. We investigated the inhibitory activity of 15d-PGJ2 on the bone loss that is associated with breast cancer bone metastasis and estrogen deficiency caused by cancer treatment. 15d-PGJ2 dose-dependently inhibited viability, migration, invasion, and parathyroid hormone-related protein (PTHrP production in MDA-MB-231 breast cancer cells. 15d-PGJ2 suppressed receptor activator of nuclear factor kappa-B ligand (RANKL mRNA levels and normalized osteoprotegerin (OPG mRNA levels in hFOB1.19 osteoblastic cells treated with culture medium from MDA-MB-231 cells or PTHrP, which decreased the RANKL/OPG ratio. 15d-PGJ2 blocked RANKL-induced osteoclastogenesis and inhibited the formation of resorption pits by decreasing the activities of cathepsin K and matrix metalloproteinases, which are secreted by mature osteoclasts. 15d-PGJ2 exerted its effects on breast cancer and bone cells via PPARγ-independent pathways. In Balb/c nu/nu mice that received an intracardiac injection of MDA-MB-231 cells, subcutaneously injected 15d-PGJ2 substantially decreased metastatic progression, cancer cell-mediated bone destruction in femora, tibiae, and mandibles, and serum PTHrP levels. 15d-PGJ2 prevented the destruction of femoral trabecular structures in estrogen-deprived ICR mice as measured by bone morphometric parameters and serum biochemical data. Therefore, 15d-PGJ2 may be beneficial for the prevention and treatment of breast cancer

Integer programming and combinatorial optimization : 15th international conference, IPCO 2011, New York NY, USA, June 15-17, 2011 : proceedings

NARCIS (Netherlands)

Günlük, O.; Woeginger, G.J.

2011-01-01

This volume contains the 33 papers presented at IPCO 2011, the 15th Conference on Integer Programming and Combinatorial Optimization, held during June 15–17, 2011 at the IBM T.J. Watson Research Center in New York, USA. IPCO conferences are sponsored by the Mathematical Optimization Society. The

AoRim15 is involved in conidial stress tolerance, conidiation and sclerotia formation in the filamentous fungus Aspergillus oryzae.

Science.gov (United States)

Nakamura, Hidetoshi; Kikuma, Takashi; Jin, Feng Jie; Maruyama, Jun-ichi; Kitamoto, Katsuhiko

2016-04-01

The serine-threonine kinase Rim15p is a master regulator of stress signaling and is required for stress tolerance and sexual sporulation in the yeast Saccharomyces cerevisiae. However, in filamentous fungi that reproduce asexually via conidiation, the physiological function of Rim15p homologs has not been extensively analyzed. Here, we functionally characterized the protein homolog of Rim15p in the filamentous fungus Aspergillus oryzae, by deleting and overexpressing the corresponding Aorim15 gene and examining the role of this protein in stress tolerance and development. Deletion of Aorim15 resulted in an increase in the sensitivity of conidia to oxidative and heat stresses, whereas conidia of the Aorim15 overexpressing strain were more resistant to these stresses. These results indicated that AoRim15 functions in stress tolerance, similar to S. cerevisiae Rim15p. Phenotypic analysis revealed that conidiation was markedly reduced by overexpression of Aorim15 in A. oryzae, and was completely abolished in the deletion strain. In addition, the formation of sclerotia, which is another type of developmental structure in filamentous fungi, was decreased by the deletion of Aorim15, whereas Aorim15 overexpression increased the number of sclerotia. These results indicated that AoRim15 is a positive regulator of sclerotia formation and that overexpression of AoRim15 shifts the developmental balance from conidiation towards sclerotia formation. Collectively, we demonstrated that AoRim15 is involved in the stress tolerance of conidia and differentially regulates between the two developmental fates of conidiation and sclerotia formation. Copyright © 2015 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Digital Denmark: From Information Society to Network Society

DEFF Research Database (Denmark)

Henten, Anders; Falch, Morten

2000-01-01

for a welfare society. However, globalisation and the spreading use of new information and communication technologies and services challenge this position. This article examines Denmark's performance in implementing its IS 2000 plans, the background to the Digital Denmark report, and its implications......The Danish Government recently issued a new policy report, Digital Denmark, on the "conversion to a network society", as a successor to its Information Society 2000 report (1994). This is part of a new round of information society policy vision statements that are, or will be forthcoming from...... national governments everywhere. Denmark provides an interesting case study because it ranks high in the benchmark indicators of information network society developments. This position has been obtained largely by public sector initiatives and without erosion of the highly reputed Scandinavian model...

Physiologic characterization of inflammatory arthritis in a rabbit model with BOLD and DCE MRI at 1.5 Tesla

Energy Technology Data Exchange (ETDEWEB)

Nasui, Otilia C.; Chan, Michael W.; Nathanael, George; Rayner, Tammy; Weiss, Ruth; Detzler, Garry; Zhong, Anguo [The Hospital for Sick Children, Department of Diagnostic Imaging, Toronto, ON (Canada); Crawley, Adrian [University of Toronto, Department of Medical Imaging, Toronto, ON (Canada); Toronto Western Hospital, Department of Medical Imaging, Toronto, ON (Canada); Miller, Elka [Children' s Hospital of Eastern Ontario (CHEO), Department of Diagnostic Imaging, Ottawa, ON (Canada); Belik, Jaques [The Hospital for Sick Children, Department of Neonatology, Toronto, ON (Canada); Cheng, Hai-Ling; Kassner, Andrea; Doria, Andrea S. [The Hospital for Sick Children, Department of Diagnostic Imaging, Toronto, ON (Canada); University of Toronto, Department of Medical Imaging, Toronto, ON (Canada); Moineddin, Rahim [Department of Public Health, Family and Community Medicine, Toronto, ON (Canada); Jong, Roland; Rogers, Marianne [Mount Sinai Hospital, Department of Pathology, Toronto, ON (Canada)

2014-11-15

Our aim was to test the feasibility of blood oxygen level dependent magnetic resonance imaging (BOLD MRI) and dynamic contrast-enhanced (DCE) MRI to monitor periarticular hypoxic/inflammatory changes over time in a juvenile rabbit model of arthritis. We examined arthritic and contralateral nonarthritic knees of 21 juvenile rabbits at baseline and days 1,14, and 28 after induction of arthritis by unilateral intra-articular injection of carrageenin with BOLD and DCE MRI at 1.5 Tesla (T). Nine noninjected rabbits served as controls. Associations between BOLD and DCE-MRI and corresponding intra-articular oxygen pressure (PO{sub 2}) and blood flow [blood perfusion units (BPU)] (polarographic probes, reference standards) or clinical-histological data were measured by correlation coefficients. Percentage BOLD MRI change obtained in contralateral knees correlated moderately with BPU on day 0 (r = -0.51, p = 0.02) and excellently on day 28 (r = -0.84, p = 0.03). A moderate correlation was observed between peak enhancement DCE MRI (day 1) and BPU measurements in arthritic knees (r = 0.49, p = 0.04). In acute arthritis, BOLD and DCE MRI highly correlated (r = 0.89, p = 0.04; r = 1.0, p < 0.0001) with histological scores in arthritic knees. The proposed techniques are feasible to perform at 1.5 T, and they hold potential as surrogate measures to monitor hypoxic and inflammatory changes over time in arthritis at higher-strength MRI fields. (orig.)

Effects of Reinforcement Method of Dissection Physiology Education on the Achievement in Pharmacology.

Science.gov (United States)

Kitayama, Tomoya; Kagota, Satomi; Yoshikawa, Noriko; Kawai, Nobuyuki; Nishimura, Kanae; Miura, Takeshi; Yasui, Naomi; Shinozuka, Kazumasa; Nakabayashi, Toshikatsu

2016-01-01

The Pharmaceutical Education Support Center was established in the Department of Pharmacy at the School of Pharmacy and Pharmaceutical Science of Mukogawa Women's University in 2014. We started teaching first and second years students according to proficiency from the 2014 academic year. Students were divided into two classes: the regular class (high proficiency class) and the basic class (low proficiency class), based on achievement in several basic subjects related to the study of pharmacy. The staffs in the Pharmaceutical Education Support Center reinforce what is taught to students in the basic class. In this reinforcement method of education, the class size is small, consisting of about 15 students, a quiz to review the previous lesson is given at the beginning of each lecture, and an additional five lectures are conducted, compared to the high proficiency class, which receives 15 lectures. In this study, we evaluated the effects of the reinforcement method of physiology education on achievement in pharmacology that was not conducted in the proficiency-dependent teaching method. The students in the basic class in physiology education were chosen based on achievement levels in anatomy. Achievement levels of pharmacology students in the basic class of physiology improved compared with those of students who had the same achievement levels in physiology but were not taught according to proficiency-dependent teaching in the 2013 academic year. These results suggest that the reinforcement method for education in basic subjects in pharmacy, such as physiology, can improve achievement in more advanced subjects, such as pharmacology.

Lack of association of genetic variation in chromosome region 15q14-22.1 with type 2 diabetes in a Japanese population

Directory of Open Access Journals (Sweden)

Ichiishi Eiichiro

2008-03-01

Full Text Available Abstract Background Chromosome 15q14-22.1 has been linked to type 2 diabetes (T2D and its related traits in Japanese and other populations. The presence of T2D disease susceptibility variant(s was assessed in the 21.8 Mb region between D15S118 and D15S117 in a Japanese population using a region-wide case-control association test. Methods A two-stage association test was performed using Japanese subjects: The discovery panel (Stage 1 used 372 cases and 360 controls, while an independent replication panel (Stage 2 used 532 cases and 530 controls. A total of 1,317 evenly-spaced, common SNP markers with minor allele frequencies > 0.10 were typed for each stage. Captured genetic variation was examined in HapMap JPT SNPs, and a haplotype-based association test was performed. Results SNP2140 (rs2412747 (C/T in intron 33 of the ubiquitin protein ligase E3 component n-recognin 1 (UBR1 gene was selected as a landmark SNP based on repeated significant associations in Stage 1 and Stage 2. However, the marginal p value (p = 0.0043 in the allelic test, OR = 1.26, 95% CI = 1.07–1.48 for combined samples was weak in a single locus or haplotype-based association test. We failed to find any significant SNPs after correcting for multiple testing. Conclusion The two-stage association test did not reveal a strong association between T2D and any common variants on chromosome 15q14-22.1 in 1,794 Japanese subjects. A further association test with a larger sample size and denser SNP markers is required to confirm these observations.

A simple fish physiological model for radioecologists exemplified for 54Mn direct transfer and rainbow trout (Oncorhynchus mykiss W.)

International Nuclear Information System (INIS)

Garnier-Laplace, Jacqueline; Adam, Christelle; Lathuilliere, Thierry; Baudin, Jean-pierre; Clabaut, Mathieu

2000-01-01

A simple kinetic model for the transfer of radionuclide to freshwater fish was formulated based on physiological (blood and flow rates), anatomical (volume of tissue compartments) and thermodynamic (tissue-to-blood partition coefficients) parameters. The present study describes 54 Mn direct transfer to young rainbow trout and exemplifies this new approach for radioecology. The model was calibrated on uptake and depuration kinetics datasets obtained for 14 organs/tissues during a 12-week experiment. Organs were classified into three compartments: an input compartment (gills), a distribution/reservoir compartment (muscles, skeleton and skin) and an excretional function compartment (digestive system and liver). For the three compartments, the partition coefficients and the residence time of the pollutant were, respectively: 161 and 4 h, 87 and 1.5 days, and 1465 and 14 days. As an indirect validation technique, a steady-state concentration factor was calculated for the whole organism from the partition coefficient values and fractional volumes of the compartment. The value of 8 l kg -1 w.w. is similar to those reported in the literature

Behavioral and emotional problems reported by parents of children ages 6 to 16 in 31 societies

NARCIS (Netherlands)

Rescorla, Leslie; Achenbach, Thomas; Ivanova, Masha Y.; Dumenci, Levent; Almqvist, Fredrik; Bilenberg, Niels; Bird, Hector; Chen, Wei; Dobrean, Anca; Doepfner, Manfred; Erol, Nese; Fombonne, Eric; Fonseca, Antonio; Frigerio, Alessandra; Grietens, Hans; Hannesdottir, Helga; Kanbayashi, Yasuko; Lambert, Michael; Larsson, Bo; Leung, Patrick; Liu, Xianchen; Minaei, Asghar; Mulatu, Mesfin S.; Novik, Torunn S.; Oh, Kyung-Ja; Roussos, Alexandra; Sawyer, Michael; Simsek, Zeynep; Steinhausen, Hans-Christoph; Weintraub, Sheila; Weisz, John; Metzke, Christa Winkler; Wolanczyk, Tomasz; Yang, Hao-Jan; Zilber, Nelly; Zukauskiene, Rita; Verhulst, Frank

2007-01-01

This study compared parents' ratings of behavioral and emotional problems on the Child Behavior Checklist (Achenbach, 199 1; Achenbach & Rescorla, 2001) for general population samples of children ages 6 to 16 from 31 societies (N = 55,508). Effect sizes for society ranged from.03 to.14. Effect sizes

Physiological Event Prediction in Evaluations of Underwater Breathing Apparatus

Science.gov (United States)

2016-10-25

Navy Experimental Diving Unit TA 15-02 321 Bullfinch Rd. NEDU TR 16-04 Panama City, FL 32407-7015 October 2016 Physiological...Diving unit 321 Bullfinch Road Panama City, Florida 32407-7015 NEDU TR 16-04 9. SPONSORING / MONITORING AGENCY...varying dive conditions. The so-called maximum respiratory impedance model was calibrated on Navy manned dive results, and this paper describes the use

Identifying N fertilizer regime and vegetable production system in tropical Brazil using (15) N natural abundance.

Science.gov (United States)

Inácio, Caio T; Urquiaga, Segundo; Chalk, Phillip M; Mata, Maria Gabriela F; Souza, Paulo O

2015-12-01

This study was conducted in areas of vegetable production in tropical Brazil, with the objectives of (i) measuring the variation in δ(15)  N in soils, organic N fertilizer sources and lettuce (Lactuca sativa L.) from different farming systems, (ii) measuring whether plant δ(15)  N can differentiate organic versus conventional lettuce and (iii) identifying the factors affecting lettuce δ(15)  N. Samples of soil, lettuce and organic inputs were taken from two organic, one conventional and one hydroponic farm. The two organic farms had different N-sources with δ(15)  N values ranging from 0.0 to +14.9‰ (e.g. leguminous green manure and animal manure compost, respectively), and differed significantly (P hydroponic lettuce δ(15)  N (+4.5 ± 0.2‰) due to manure inputs. The N from leguminous green manure made a small contribution to the N nutrition of lettuce in the multi-N-source organic farm. To differentiate organic versus conventional farms using δ(15)  N the several subsets of mode of fertilization should be considered. Comparisons of δ(15)  N of soil, organic inputs and lettuce allowed a qualitative analysis of the relative importance of different N inputs. © 2015 Society of Chemical Industry.

Effects of shoe cleat position on physiology and performance of competitive cyclists.

Science.gov (United States)

Paton, Carl D

2009-12-01

Aerobic economy is an important factor that affects the performance of competitive cyclists. It has been suggested that placing the foot more anteriorly on the bicycle pedals may improve economy over the traditional foot position by improving pedaling efficiency. The current study examines the effects of changing the anterior-posterior pedal foot position on the physiology and performance of well-trained cyclists. In a crossover study, 10 competitive cyclists completed two maximal incremental and two submaximal tests in either their preferred (control) or a forward (arch) foot position. Maximum oxygen consumption and peak power output were determined from the incremental tests for both foot positions. On two further occasions, cyclists also completed a two-part 60-min submaximal test that required them to maintain a constant power output (equivalent to 60% of their incremental peak power) for 30 min, during which respiratory and blood lactate samples were taken at predetermined intervals. Thereafter, subjects completed a 30-min self-paced maximal effort time trial. Relative to the control, the mean changes (+/-90% confidence limits) in the arch condition were as follows: maximum oxygen consumption, -0.5% (+/-2.0%); incremental peak power output, -0.8% (+/-1.3%); steady-state oxygen consumption at 60%, -2.4% (+/-1.1%); steady-state heart rate 60%, 0.4% (+/-1.7%); lactate concentration 60%, 8.7% (+/-14.4%); and mean time trial power, -1.5% (+/-2.9%). We conclude that there was no substantial physiological or performance advantage in this group using an arch-cleat shoe position in comparison with a cyclist's normal preferred condition.

Best practices for learning physiology: combining classroom and online methods.

Science.gov (United States)

Anderson, Lisa C; Krichbaum, Kathleen E

2017-09-01

Physiology is a requisite course for many professional allied health programs and is a foundational science for learning pathophysiology, health assessment, and pharmacology. Given the demand for online learning in the health sciences, it is important to evaluate the efficacy of online and in-class teaching methods, especially as they are combined to form hybrid courses. The purpose of this study was to compare two hybrid physiology sections in which one section was offered mostly in-class (85% in-class), and the other section was offered mostly online (85% online). The two sections in 2 yr ( year 1 and year 2 ) were compared in terms of knowledge of physiology measured in exam scores and pretest-posttest improvement, and in measures of student satisfaction with teaching. In year 1 , there were some differences on individual exam scores between the two sections, but no significant differences in mean exam scores or in pretest-posttest improvements. However, in terms of student satisfaction, the mostly in-class students in year 1 rated the instructor significantly higher than did the mostly online students. Comparisons between in-class and online students in the year 2 cohort yielded data that showed that mean exam scores were not statistically different, but pre-post changes were significantly greater in the mostly online section; student satisfaction among mostly online students also improved significantly. Education researchers must investigate effective combinations of in-class and online methods for student learning outcomes, while maintaining the flexibility and convenience that online methods provide. Copyright © 2017 the American Physiological Society.

Spiritual Needs among Patients with Chronic Pain Diseases and Cancer Living in a Secular Society

DEFF Research Database (Denmark)

Büssing, Arndt; Janko, Annina; Baumann, Klaus

2013-01-01

. Methods In an anonymous cross-sectional study, standardized questionnaires were provided to German patients with chronic pain diseases (and cancer), i.e., Spiritual Needs Questionnaire (SpNQ), Spirituality/Religiosity and Coping (SpREUK-15), Spiritual Well-being (FACIT-Sp), Brief Multidimensional Life......Objective Research has shown that several patients report unmet psychosocial and spiritual needs. While most studies focus on patients with advanced stages of disease, we intended to identify unmet spiritual needs in patients with chronic pain diseases and cancer living in a secular society...... Satisfaction Scale, Interpretation of Illness Questionnaire, and Escape from Illness (Escape). Results We enrolled 392 patients (67% women, mean age 56.3 ± 13.6 years; 61% Christian denomination) with chronic pain diseases (86%) and cancer (14%). Religious Needs (mean score 0.5 ± 0.8 on the scale...

Brief overview of American Nuclear Society's research reactor standards

International Nuclear Information System (INIS)

Richards, Wade J.

1984-01-01

The American Nuclear Society (ANS) established the research reactor standards group in 1968. The standards group, known as ANS-15, was established for the purpose of developing, preparing, and maintaining standards for the design, construction, operation, maintenance, and decommissioning of nuclear reactors intended for research and training

Physiological coherence in healthy volunteers during laboratory-induced stress and controlled breathing.

Science.gov (United States)

Mejía-Mejía, Elisa; Torres, Robinson; Restrepo, Diana

2018-06-01

Physiological coherence has been related with a general sense of well-being and improvements in health and physical, social, and cognitive performance. The aim of this study was to evaluate the relationship between acute stress, controlled breathing, and physiological coherence, and the degree of body systems synchronization during a coherence-generation exercise. Thirty-four university employees were evaluated during a 20-min test consisting of four stages of 5-min duration each, during which basal measurements were obtained (Stage 1), acute stress was induced using validated mental stressors (Stroop test and mental arithmetic task, during Stage 2 and 3, respectively), and coherence states were generated using a controlled breathing technique (Stage 4). Physiological coherence and cardiorespiratory synchronization were assessed during each stage from heart rate variability, pulse transit time, and respiration. Coherence measurements derived from the three analyzed variables increased during controlled respiration. Moreover, signals synchronized during the controlled breathing stage, implying a cardiorespiratory synchronization was achieved by most participants. Hence, physiological coherence and cardiopulmonary synchronization, which could lead to improvements in health and better life quality, can be achieved using slow, controlled breathing exercises. Meanwhile, coherence measured during basal state and stressful situations did not show relevant differences using heart rate variability and pulse transit time. More studies are needed to evaluate the ability of coherence ratio to reflect acute stress. © 2017 Society for Psychophysiological Research.

Overview of the Anatomy, Physiology, and Pharmacology of the Autonomic Nervous System.

Science.gov (United States)

Wehrwein, Erica A; Orer, Hakan S; Barman, Susan M

2016-06-13

Comprised of the sympathetic nervous system, parasympathetic nervous system, and enteric nervous system, the autonomic nervous system (ANS) provides the neural control of all parts of the body except for skeletal muscles. The ANS has the major responsibility to ensure that the physiological integrity of cells, tissues, and organs throughout the entire body is maintained (homeostasis) in the face of perturbations exerted by both the external and internal environments. Many commonly prescribed drugs, over-the-counter drugs, toxins, and toxicants function by altering transmission within the ANS. Autonomic dysfunction is a signature of many neurological diseases or disorders. Despite the physiological relevance of the ANS, most neuroscience textbooks offer very limited coverage of this portion of the nervous system. This review article provides both historical and current information about the anatomy, physiology, and pharmacology of the sympathetic and parasympathetic divisions of the ANS. The ultimate aim is for this article to be a valuable resource for those interested in learning the basics of these two components of the ANS and to appreciate its importance in both health and disease. Other resources should be consulted for a thorough understanding of the third division of the ANS, the enteric nervous system. © 2016 American Physiological Society. Compr Physiol 6:1239-1278, 2016. Copyright © 2016 John Wiley & Sons, Inc.

Assessment of acute physiological demand for soccer

OpenAIRE

Daniel Barbosa Coelho; Eduardo Mendonça Pimenta; Christiano Eduardo Veneroso; Rodrigo Figueiredo Morandi; Diogo Antônio Soares Pacheco; Emerson Rodrigues Pereira; Leonardo Gomes Martins Coelho; Emerson Silami Garcia

2013-01-01

DOI: http://dx.doi.org/10.5007/1980-0037.2013v15n6p667 Soccer is a sport practiced worldwide, on all continents. It is considered an intermittent activity of high intensity and long duration, in which movements that require great strength and speed, such as jumps and sprints, result in high levels of muscle microtrauma, hampering athletes’ training and recovery. The present study aimed to evaluate the magnitude of changes in different markers of physiological demand resulting from a socce...

Effects of competitive pressure on expert performance: underlying psychological, physiological, and kinematic mechanisms.

Science.gov (United States)

Cooke, Andrew; Kavussanu, Maria; McIntyre, David; Boardley, Ian D; Ring, Christopher

2011-08-01

Although it is well established that performance is influenced by competitive pressure, our understanding of the mechanisms which underlie the pressure-performance relationship is limited. The current experiment examined mediators of the relationship between competitive pressure and motor skill performance of experts. Psychological, physiological, and kinematic responses to three levels of competitive pressure were measured in 50 expert golfers, during a golf putting task. Elevated competitive pressure increased putting accuracy, anxiety, effort, and heart rate, but decreased grip force. Quadratic effects of pressure were noted for self-reported conscious processing and impact velocity. Mediation analyses revealed that effort and heart rate partially mediated improved performance. The findings indicate that competitive pressure elicits effects on expert performance through both psychological and physiological pathways. Copyright © 2011 Society for Psychophysiological Research.

MODERN TEENAGER (HIGHLANDER AND SEX

Directory of Open Access Journals (Sweden)

Oksana Fedyk

2015-04-01

Full Text Available The age at which you can start or be sexually active - a very interesting question, which concerned not only parents, but also psychologists. Usually, you can not answer the question of when and to whom to start having sex. However, there are certain statistics that the average age of sexual debut in adolescents - is 15 years for girls and 14 for boys. Now we are talking about European society, about what is happening in Ukraine, particularly in mountainous areas. The fact that the willingness in principle to sexual intercourse is associated with physiological aspects. There is a notion in sexology - sexual constitution. There are several factors play a role, of course, one of which is constitutional, but not always, psychological maturity and sexual constitution, rather, because of the need for sexual constitution in holding intercourse can match. That is, some teens may be physiologically ready for sexual intercourse at 12-13 years, but the question arises: Are they psychologically? And probably we can not give a definite answer to this question, because curiosity taboo in society, which in the majority rejects teen sex, pushing them into early sexual relations. Nevertheless, probably still age readiness and psychological and physiological - is 18-19 years if we are talking about teen sex.

Craniomaxillofacial Trauma: Synopsis of 14,654 Cases with 35,129 Injuries in 15 Years

Science.gov (United States)

Kraft, Anna; Abermann, Elisabeth; Stigler, Robert; Zsifkovits, Clemens; Pedross, Florian; Kloss, Frank; Gassner, Robert

2011-01-01

Craniomaxillofacial (CMF) trauma occurs in isolation or in combination with other serious injuries, including intracranial, spinal, and upper- and lower-body injuries. It is a major cause of expensive treatment and rehabilitation requirements, temporary or lifelong morbidity, and loss of human productivity. The aim of this study was to evaluate patterns of CMF trauma in a large patient sample within a 15-year time frame. Between 1991 and 2005, CMF trauma data were collected from 14,654 patients with 35,129 injuries at the Department of Cranio-Maxillofacial and Oral Surgery in Innsbruck, assessing a plethora of parameters such as injury type and mechanism as well as age and gender distribution over time. Three main groups of CMF trauma were evaluated: facial bone fractures, dentoalveolar trauma, and soft tissue injuries. Statistical comparisons were carried out using a chi-square test. This was followed by a logistic regression analysis to determine the impact of the five main causes for CMF injury. Older people were more prone to soft tissue lesions with a rising risk of 2.1% per year older, showing no significant difference between male and female patients. Younger patients were at higher risk of suffering from dentoalveolar trauma with an increase of 4.4% per year younger. This number was even higher (by 19.6%) for female patients. The risk of sustaining facial bone fractures increased each year by 4.6%. Male patients had a 66.4% times higher risk of suffering from this type of injury. In addition, 2550 patients (17.4%) suffered from 3834 concomitant injuries of other body parts. In summary, we observed changing patterns of CMF trauma over the last 15 years, paralleled by advances in refined treatment and management options for rehabilitation and reconstruction of patients suffering from CMF trauma. PMID:23449961

15N fractionation in infrared-dark cloud cores

Science.gov (United States)

Zeng, S.; Jiménez-Serra, I.; Cosentino, G.; Viti, S.; Barnes, A. T.; Henshaw, J. D.; Caselli, P.; Fontani, F.; Hily-Blant, P.

2017-07-01

Context. Nitrogen is one of the most abundant elements in the Universe and its 14N/15N isotopic ratio has the potential to provide information about the initial environment in which our Sun formed. Recent findings suggest that the solar system may have formed in a massive cluster since the presence of short-lived radioisotopes in meteorites can only be explained by the influence of a supernova. Aims: We seek to determine the 14N/15N ratio towards a sample of cold and dense cores at the initial stages in their evolution. Methods: We observed the J = 1 → 0 transitions of HCN, H13CN, HC15N, HN13C, and H15NC towards a sample of 22 cores in four infrared-dark clouds (IRDCs) which are believed to be the precursors of high-mass stars and star clusters. Assuming LTE and a temperature of 15 K, the column densities of HCN, H13CN, HC15N, HN13C, and H15NC are calculated and their 14N/15N ratio is determined for each core. Results: The 14N/15N ratios measured in our sample of IRDC cores range between 70 and ≥763 in HCN and between 161 and 541 in HNC. These ratios are consistent with the terrestrial atmosphere (TA) and protosolar nebula (PSN) values, and with the ratios measured in low-mass prestellar cores. However, the 14N/15N ratios measured in cores C1, C3, F1, F2, and G2 do not agree with the results from similar studies towards the same cores using nitrogen bearing molecules with nitrile functional group (-CN) and nitrogen hydrides (-NH) although the ratio spread covers a similar range. Conclusions: Relatively low 14N/15N ratios amongst the four-IRDCs were measured in IRDC G which are comparable to those measured in small cosmomaterials and protoplanetary disks. The low average gas density of this cloud suggests that the gas density, rather than the gas temperature, may be the dominant parameter influencing the initial nitrogen isotopic composition in young PSN. The reduced spectra (FITS files) are only available at the CDS via anonymous ftp to http

New Marxian Times! Reflections on the 4th ICTs and Society Conference “Critique, Democracy and Philosophy in 21st Century Information Society. Towards Critical Theories of Social Media”.

Directory of Open Access Journals (Sweden)

Christian Fuchs

2012-05-01

Full Text Available This paper presents reflections on the conference “Critique, Democracy and Philosophy in 21st Century Information Society. Towards Critical Theories of the Information Society” that took place at Uppsala University from May 2nd-4th, 2012. About 160 participants attended the conference. It featured 15 plenary talks in seven sessions, 15 paper presentation sessions organised in 5 slots that each had 3 parallel sessions. The conference was financially supported by the Swedish Research Council and organised by Uppsala University’s Department of Informatics and Media, the ICTs and Society Network (http://www.icts-and-society.net, the European Sociological Association’s Research Network 18: Sociology of Communications and Media Research (http://www.europeansociology.org/research-networks/rn18-sociology-of-communications-and-media-research.html, tripleC – Open Access Journal for a Global Sustainable Information Society (http://www.triple-c.at, the Unified Theory of Information Research Group (UTI, Aarhus University’s Department of Information and Media Studies, the Vienna University of Technology’s Institute for Design & Assessment of Technology, and Jönköping University’s  School of Education and Communication.