WorldWideScience

Sample records for periphery coordination event

  1. On the Relationality of Centers, Peripheries and Interactional Regimes: Translanguaging in a Community Interpreting Event

    Science.gov (United States)

    Baynham, Mike; Hanušová, Jolana

    2017-01-01

    In this paper we discuss a multilingual interactional event that involves both interpreting and literacy work, part of a large scale study on translanguaging in superdiverse urban settings. In the first part of the interaction, the center/periphery dynamic is played out in what might be called "contested translanguaging" between Standard…

  2. Coordinating the Atlantis Grand Opening Event

    Science.gov (United States)

    Smith, Abigail Allaine

    2013-01-01

    While working as the marketing intern for Kennedy Space Center's (KSC) Center Planning and Development Directorate (CPD), I was given the opportunity not only to learn new skills and expand my work experience under the powerful influence of NASA, but I also was given the opportunity to prove that I am an individual capable of contributing to the KSC team. My main responsibility while working in CPD was to organize and run a booth that represented the entire directorate at the Grand Opening of the Shuttle Atlantis exhibit during the weekend of June 28-30. This event was important for CPD because as a Directorate that markets KSC's facilities, technical capabilities and technologies to potential partners, it is important to attend all events and use them to gain an understanding of our audience. Although we catered mostly to the general public during this event, it was still important to reach out to the larger space enthusiast community and let them know about KSC's future plans to become a multi-user spaceport and that teclmology is still being developed.

  3. Managing nonroutine events in anesthesia: the role of adaptive coordination.

    Science.gov (United States)

    Burtscher, Michael J; Wacker, Johannes; Grote, Gudela; Manser, Tanja

    2010-04-01

    This field study aimed at examining the role of anesthesia teams' adaptive coordination in managing changing situational demands, such as in nonroutine events (NREs). Medical teams' ability to adapt their teamwork (e.g., their coordination activities) to changing situational demands is crucial to team performance and, thus, to patient safety. Whereas the majority of previous studies on the matter have focused on critical but rare events, it has recently been pointed out that the effective management of NREs is a key challenge to medical teams. Hence this study investigated the relationship between coordination activities, NRE occurrence, and team performance. We videotaped 22 anesthesia teams during standard anesthesia induction and recorded data from the vital signs monitor and the ventilator. Coordination was coded by a trained observer using a structured observation system. NREs were recorded by an experienced staff anesthesiologist using all three video streams. Checklist-based team performance assessment was also performed by an experienced staff anesthesiologist. We found that anesthesia teams adapt their coordination activities to changing situational demands. In particular, the increased occurrence of NREs caused an increase in the time the teams spent on task management. A stronger increase in the teams' task management (i.e., more adaptive coordination) was related to their performance. Our results emphasize the importance of adaptive coordination in managing NREs effectively. This study provides valuable information for developing novel team training programs in health care that focus on adaptation to changing task requirements, for example, when faced with NREs.

  4. Integrating Behaviour in Software Models: An Event Coordination Notation

    DEFF Research Database (Denmark)

    Kindler, Ekkart

    2011-01-01

    One of the main problems in model-based software engineering is modelling behaviour in such a way that the behaviour models can be easily integrated with each other, with the structural software models and with pre-existing software. In this paper, we propose an event coordination notation (ECNO)...

  5. From Periphery To Center

    DEFF Research Database (Denmark)

    Carré, David

    2014-01-01

    the notions of Center/Periphery. As Hermans (2001) proposed, center and periphery are not fixed ‘I-positions’ of the self; in this vein, these notions are explored as relevant theoretical tools for addressing the developmental trajectories involved in the construction of scientific identities. In sum...

  6. The Event Coordination Notation: Execution Engine and Programming Framework

    DEFF Research Database (Denmark)

    Kindler, Ekkart

    2012-01-01

    that was written manually. In this paper, we rephrase the main concepts of ECNO. The focus of this paper, however, is on the architecture of the ECNO execution engine and its programming framework. We will show how this framework allows us to integrate ECNO with object-oriented models, how it works without any......ECNO (Event Coordination Notation) is a notation for modelling the behaviour of a software system on top of some object-oriented data model. ECNO has two main objectives: On the one hand, ECNO should allow modelling the behaviour of a system on the domain level; on the other hand, it should...... be possible to completely generate code from ECNO and the underlying object-oriented domain models. Today, there are several approaches that would allow to do this. But, most of them would require that the data models and the behaviour models are using the same technology and the code is generated together...

  7. The Event Coordination Notation: Behaviour Modelling Beyond Mickey Mouse

    DEFF Research Database (Denmark)

    Jepsen, Jesper; Kindler, Ekkart

    2015-01-01

    The Event Coordination Notation (ECNO) allows modelling the desired behaviour of a software system on top of any object-oriented software. Together with existing technologies from Model-based Software Engineering (MBSE) for automatically generating the software for the structural parts, ECNO allows...... special aspect of ECNO or another; and it would be fair to call them “Mickey Mouse examples”. In this paper, we give a concise overview of the motivation, ideas, and concepts of ECNO. More importantly, we discuss a larger system, which was completely generated from the underlying models: a workflow...... management system. This way, we demonstrate that ECNO can be used for modelling software beyond the typical Mickey Mouse examples. This example demonstrates that the essence of workflow management – including its behaviour – can be captured in ECNO: in a sense, it is a domain model of workflow management...

  8. Periphery and archaic forms

    NARCIS (Netherlands)

    Hillenius, D.

    1964-01-01

    In many groups the more primitive, more ancestor-like species are living in the periphery of the range of the group. Many authors have regarded this phenomenon as a rule, e.g. MATTHEW, 1915: ”Whatever agencies may be assigned as the cause of evolution of a race, it should be at first most

  9. Views from the "Periphery"

    DEFF Research Database (Denmark)

    Jansson, Johanna

    2012-01-01

    China’s rise has produced a variety of impulses on the African continent. The understanding of these dynamics is essential for this book’s endeavour to explore how China’s rise impacts on semi-periphery and periphery countries. This chapter makes a contribution in this regard by means of a case...... study of one African country, the Democratic Republic of Congo (DRC), a country which indeed could be labelled ‘periphery’. While the current changes in China have been underway since 1978, as discussed in this book’s introduction, Sino-African relations only started to gain importance from 2000 onwards......, but the picture is more complex. The Chinese presence in Africa is equally driven by market seeking and diplomatic dynamics unrelated to the need for natural resources. This argument has indeed been made by a number of scholars (e.g. Brautigam 2009, Mohan and Power 2008, Snow 2008) but has to date not been...

  10. Coordination control of discrete-event systems revisited

    Czech Academy of Sciences Publication Activity Database

    Komenda, Jan; Masopust, Tomáš; van Schuppen, J. H.

    2015-01-01

    Roč. 25, 1-2 (2015), s. 65-94 ISSN 0924-6703 R&D Projects: GA ČR(CZ) GPP202/11/P028; GA ČR(CZ) GAP103/11/0517 Institutional support: RVO:67985840 Keywords : coordination control * supervisory control Subject RIV: BA - General Mathematics Impact factor: 1.268, year: 2015 http://link.springer.com/article/10.1007%2Fs10626-013-0179-x

  11. Scanning the periphery.

    Science.gov (United States)

    Day, George S; Schoemaker, Paul J H

    2005-11-01

    Companies often face new rivals, technologies, regulations, and other environmental changes that seem to come out of left field. How can they see these changes sooner and capitalize on them? Such changes often begin as weak signals on what the authors call the periphery, or the blurry zone at the edge of an organization's vision. As with human peripheral vision, these signals are difficult to see and interpret but can be vital to success or survival. Unfortunately, most companies lack a systematic method for determining where on the periphery they should be looking, how to interpret the weak signals they see, and how to allocate limited scanning resources. This article provides such a method-a question-based framework for helping companies scan the periphery more efficiently and effectively. The framework divides questions into three categories: learning from the past (What have been our past blind spots? What instructive analogies do other industries offer? Who in the industry is skilled at picking up weak signals and acting on them?); evaluating the present (What important signals are we rationalizing away? What are our mavericks, outliers, complainers, and defectors telling us? What are our peripheral customers and competitors really thinking?); and envisioning the future (What future surprises could really hurt or help us? What emerging technologies could change the game? Is there an unthinkable scenario that might disrupt our business?). Answering these questions is a good first step toward anticipating problems or opportunities that may appear on the business horizon. The article concludes with a self-test that companies can use to assess their need and capability for peripheral vision.

  12. Coordination activities of human planners during rescheduling: Case analysis and event handling procedure

    OpenAIRE

    2010-01-01

    Abstract This paper addresses the process of event handling and rescheduling in manufacturing practice. Firms are confronted with many diverse events, like new or changed orders, machine breakdowns, and material shortages. These events influence the feasibility and optimality of schedules, and thus induce rescheduling. In many manufacturing firms, schedules are created by several human planners. Coordination between them is needed to respond to events adequately. In this paper,...

  13. Translating and coordinating face in triadic speech events

    DEFF Research Database (Denmark)

    Jacobsen, Bente

    participants, their specified role of either questioners or respondents, and the purpose of the event, i.e. the extraction of evidence. Thus, the results of a recent investigation by this author of the interpreter-mediated questioning of a defendant in a criminal trial in a Danish district court suggest......This paper reports on an on-going investigation of face in interpreter-mediated questionings in criminal proceedings in Danish district courts. The languages involved are Danish and English, and the mode of interpreting is the consecutive mode. The court interpreters are all state-authorized court...... interpreters and thus fully competent professionals. The concept of face employed in the present investigation is the one proposed by Brown & Levinson (1987) in their politeness theory. Various studies of triadic speech events have pointed to the significance of face within the framework of this theory...

  14. Mosaic evolution of the mammalian auditory periphery.

    Science.gov (United States)

    Manley, Geoffrey A

    2013-01-01

    The classical mammalian auditory periphery, i.e., the type of middle ear and coiled cochlea seen in modern therian mammals, did not arise as one unit and did not arise in all mammals. It is also not the only kind of auditory periphery seen in modern mammals. This short review discusses the fact that the constituents of modern mammalian auditory peripheries arose at different times over an extremely long period of evolution (230 million years; Ma). It also attempts to answer questions as to the selective pressures that led to three-ossicle middle ears and the coiled cochlea. Mammalian middle ears arose de novo, without an intermediate, single-ossicle stage. This event was the result of changes in eating habits of ancestral animals, habits that were unrelated to hearing. The coiled cochlea arose only after 60 Ma of mammalian evolution, driven at least partly by a change in cochlear bone structure that improved impedance matching with the middle ear of that time. This change only occurred in the ancestors of therian mammals and not in other mammalian lineages. There is no single constellation of structural features of the auditory periphery that characterizes all mammals and not even all modern mammals.

  15. Event heap: a coordination infrastructure for dynamic heterogeneous application interactions in ubiquitous computing environments

    Science.gov (United States)

    Johanson, Bradley E.; Fox, Armando; Winograd, Terry A.; Hanrahan, Patrick M.

    2010-04-20

    An efficient and adaptive middleware infrastructure called the Event Heap system dynamically coordinates application interactions and communications in a ubiquitous computing environment, e.g., an interactive workspace, having heterogeneous software applications running on various machines and devices across different platforms. Applications exchange events via the Event Heap. Each event is characterized by a set of unordered, named fields. Events are routed by matching certain attributes in the fields. The source and target versions of each field are automatically set when an event is posted or used as a template. The Event Heap system implements a unique combination of features, both intrinsic to tuplespaces and specific to the Event Heap, including content based addressing, support for routing patterns, standard routing fields, limited data persistence, query persistence/registration, transparent communication, self-description, flexible typing, logical/physical centralization, portable client API, at most once per source first-in-first-out ordering, and modular restartability.

  16. Synthesis of controllable and normal sublanguages for discrete-event systems using a coordinator

    Czech Academy of Sciences Publication Activity Database

    Komenda, Jan; Masopust, Tomáš; van Schuppen, J. H.

    2011-01-01

    Roč. 60, č. 7 (2011), s. 492-502 ISSN 0167-6911 R&D Projects: GA ČR(CZ) GAP103/11/0517; GA ČR(CZ) GPP202/11/P028 Grant - others:European Commission(XE) EU.ICT.DISC 224498 Institutional research plan: CEZ:AV0Z10190503 Keywords : discrete-event system * coordination control * coordinator Subject RIV: BA - General Mathematics Impact factor: 1.222, year: 2011 http://www.sciencedirect.com/science/article/pii/S0167691111000739

  17. Synthesis of controllable and normal sublanguages for discrete-event systems using a coordinator

    Czech Academy of Sciences Publication Activity Database

    Komenda, Jan; Masopust, Tomáš; van Schuppen, J. H.

    2011-01-01

    Roč. 60, č. 7 (2011), s. 492-502 ISSN 0167-6911 R&D Projects: GA ČR(CZ) GAP103/11/0517; GA ČR(CZ) GPP202/11/P028 Grant - others:European Commission(XE) EU. ICT .DISC 224498 Institutional research plan: CEZ:AV0Z10190503 Keywords : discrete-event system * coordination control * coordinator Subject RIV: BA - General Mathematics Impact factor: 1.222, year: 2011 http://www.sciencedirect.com/science/article/pii/S0167691111000739

  18. Behavior coordination of mobile robotics using supervisory control of fuzzy discrete event systems.

    Science.gov (United States)

    Jayasiri, Awantha; Mann, George K I; Gosine, Raymond G

    2011-10-01

    In order to incorporate the uncertainty and impreciseness present in real-world event-driven asynchronous systems, fuzzy discrete event systems (DESs) (FDESs) have been proposed as an extension to crisp DESs. In this paper, first, we propose an extension to the supervisory control theory of FDES by redefining fuzzy controllable and uncontrollable events. The proposed supervisor is capable of enabling feasible uncontrollable and controllable events with different possibilities. Then, the extended supervisory control framework of FDES is employed to model and control several navigational tasks of a mobile robot using the behavior-based approach. The robot has limited sensory capabilities, and the navigations have been performed in several unmodeled environments. The reactive and deliberative behaviors of the mobile robotic system are weighted through fuzzy uncontrollable and controllable events, respectively. By employing the proposed supervisory controller, a command-fusion-type behavior coordination is achieved. The observability of fuzzy events is incorporated to represent the sensory imprecision. As a systematic analysis of the system, a fuzzy-state-based controllability measure is introduced. The approach is implemented in both simulation and real time. A performance evaluation is performed to quantitatively estimate the validity of the proposed approach over its counterparts.

  19. Non-Cooperative Regulation Coordination Based on Game Theory for Wind Farm Clusters during Ramping Events

    DEFF Research Database (Denmark)

    Qi, Yongzhi; Liu, Yutian; Wu, Qiuwei

    2017-01-01

    With increasing penetration of wind power in power systems, it is important to track scheduled wind power output as much as possible during ramping events to ensure security of the system. In this paper, a non‐cooperative coordination strategy based on the game theory is proposed for the regulation...... of the regulation revenue function according to the derived Nash equilibrium condition, the ER strategy is the Nash equilibrium of the regulation competition. Case studies were conducted with the power output data of wind farms from State Grid Jibei Electric Power Company Limited of China to demonstrate...

  20. Methods of reconstruction of multi-particle events in the new coordinate-tracking setup

    Science.gov (United States)

    Vorobyev, V. S.; Shutenko, V. V.; Zadeba, E. A.

    2018-01-01

    At the Unique Scientific Facility NEVOD (MEPhI), a large coordinate-tracking detector based on drift chambers for investigations of muon bundles generated by ultrahigh energy primary cosmic rays is being developed. One of the main characteristics of the bundle is muon multiplicity. Three methods of reconstruction of multiple events were investigated: the sequential search method, method of finding the straight line and method of histograms. The last method determines the number of tracks with the same zenith angle in the event. It is most suitable for the determination of muon multiplicity: because of a large distance to the point of generation of muons, their trajectories are quasiparallel. The paper presents results of application of three reconstruction methods to data from the experiment, and also first results of the detector operation.

  1. A coordinated two-satellite study of energetic electron precipitation events

    International Nuclear Information System (INIS)

    Imhof, W.L.; Nakano, G.H.; Gaines, E.E.; Reagan, J.B.

    1975-01-01

    A new technique for studying the spatial/temporal variations of energetic electron precipitation events is investigated. Data are presented in which precipitating electrons were measured simultaneously on two coordinated polar-orbiting satellites and the bremsstrahlung produced by the electrons precipitating into the atmosphere was observed from one of the satellites. Two electron spectrometers measuring the intensities and energy spectra of electrons of >130 keV were located on the oriented satellite 1971-089A (altitude, approx. =800 km), whereas a single similar spectrometer measuring electrons of >160 keV was located on the spinning low-altitude (approx.750 km) satellite 1972-076B. The X rays of >50 keV were measured with a 50-cm 3 germanium spectrometer placed on the 1972-076B satellite. With the coordinated data a study is made of events in which large fluctuations were observed in the precipitating energetic electron intensities. In the examples presented the satellite X ray data alone demonstrate that the spatially integrated electron influx was constant in time, and when the X ray data are combined with the direct electron measurements from the two satellites, the resulting data suggest that the major features in the flux profiles were primarily spatial in nature. The combination of X ray and electron measurements from two satellites is shown to provide an important method for studying and attempting to resolve spatial and temporal effects

  2. Network brokers in the periphery

    DEFF Research Database (Denmark)

    Leick, Birgit; Gretzinger, Susanne; Ingstrup, Mads Bruun

    in a way that both enterprise development and regional competitiveness in rural-peripheral regions are supported. Based on a case study of four network brokers from peripheral regions in Germany, we shed light on the activities of brokers with regard to networking among local businesses and the effects...... on knowledge sharing. The paper will also critically discuss governance implications of network brokers in the periphery, which are associated with the (lack of) integration of such actors with established local and regional governance infrastructures.......Research on rural-peripheral regions stresses that such environments face multiple challenges in a globalised world, which, from a policy perspective, should be addressed to enhance regional competitiveness. These challenges are typically associated with a prevalence of small and medium...

  3. Gender in science: a periphery?

    Energy Technology Data Exchange (ETDEWEB)

    Van der Weijden, I.; Reale, E.; Meijer, I.

    2016-07-01

    The academic world has been dominated by men for a long time. However, in recent decades, there have been strides towards gender balance within the pool of higher education graduates. Whilst women were once under-represented at doctoral level, they now made up 47 % of PhD graduates in the EU (European Commission 2015). Although female researchers are improving their position, the process especially in higher positions is rather slow. Is the weak position due to women having in average fewer ambitions in pursuing an academic career? Are career decisions characterized by gendered social closure, structurally disadvantaging women? Or are women weakly represented in high ranks because their male colleagues outperform them? Providing robust answers to the mentioned questions is not simple and even framing sound indicators useful to approximate the phenomenon is still a challenge for scholars dealing with science and technology policy. Therefore, in the context of the conference theme, the question is whether we still could consider gender as a periphery in science. And in particular, what aspects of gender differences in science are in particular affected? Career paths, mobility, performance, leadership and / or funding? These are the topics we want to discuss in a special session of 90 minutes at the STI2016 conference. (Author)

  4. Identification of Pathways Required for the Coordination of Late Mitotic Events in Animal Cells

    National Research Council Canada - National Science Library

    Baumgartner, Bridget L; Harper, J. W

    2005-01-01

    ... in genomic instability, a hallmark of cancer. In yeast, a signaling pathway has been identified, called the Mitotic Exit Network, which coordinates mitotic exit and cytokinesis with the end of anaphase...

  5. Identification of Pathways Required for the Coordination of Late Mitotic Events in Animal Cells

    National Research Council Canada - National Science Library

    Baumgartner, Bridget

    2004-01-01

    ... in genomic instability, a hallmark of cancer. In yeast, a signaling pathway has been identified, called the Mitotic Exit Network, which coordinates mitotic exit and cytokinesis with the end of anaphase...

  6. Provincializing and Localizing Core-Periphery Relations

    Directory of Open Access Journals (Sweden)

    Cilja Harders

    2015-11-01

    Full Text Available The paper engages engages with core-periphery conceptions because they are a useful "Denkfigur" in a time of increasing global interconnectedness. I argue that the core-periphery metaphor is a useful one because it provides us (1 with a relational tool of analysis and (2 with a focus on asymmetric power-relations. But it also has some serious limitations such as a tendency to be over-deterministic and to be too global in scale. In order to meet these limitations, I suggest to re-scale Prebisch, Amin and Wallersteins global conception of core and periphery to the local scale. I hold that we need to “provincialise” the core-periphery metaphor to borrow Chakrabarty’s (2000 famous term and to make the agency of local actors more relevant to our understanding of political dynamics in the Maghreb, Mashreq and Gulf region. I sketch how “provincialized” and “localized” ways of using the core-periphery metaphor could look like. This part builds on the main ideas Malika Bouziane, Anja Hoffmann and I developed in the introduction to our volume on “Local Politics and Contemporary Transformations in the Arab World” as well as my approach of a “state analysis from below”.

  7. Discrete-event simulation of coordinated multi-point joint transmission in LTE-Advanced with constrained backhaul

    DEFF Research Database (Denmark)

    Artuso, Matteo; Christiansen, Henrik Lehrmann

    2014-01-01

    Inter-cell interference in LTE-Advanced can be mitigated using coordinated multi-point (CoMP) techniques with joint transmission of user data . However, this requires tight coordination of the eNodeBs, usin g the X2 interface. In this paper we use discrete-event simulation to evaluate the latency...... requirements for the X2 interface and investigate the consequences of a constrained ba ckhaul. Our simulation results show a gain of the system throug hput of up to 120% compared to the case without CoMP for low-latency backhaul. With X2 latencies above 5 ms CoMP is no longer a benefit to the network....

  8. Vertical Wave Coupling associated with Stratospheric Sudden Warming Events analyzed in an Isentropic-Coordinate NWP Model.

    Science.gov (United States)

    Bleck, R.; Sun, S.; Benjamin, S.; Brown, J. M.

    2017-12-01

    Two- to four-week predictions of stratospheric sudden warming events during the winter seasons of 1999-2014, carried out with a high-resolution icosahedral NWP model using potential temperature as vertical coordinate, are inspected for commonalities in the evolution of both minor and major warmings. Emphasis is on the evolution of the potential vorticity field at different levels in the stratosphere, as well as on the sign and magnitude of the vertical component of the Eliassen-Palm flux vector suggestive of wave forcing in either direction. Material is presented shedding light on the skill of the model (FIM, developed at NOAA/ESRL) in predicting stratospheric warmings generally 2 weeks in advance. With an icosahedral grid ideally suited for studying polar processes, and a vertical coordinate faithfully reproducing details in the evolution of the potential vorticity and EP flux vector fields, FIM is found to be a good tool for investigating the SSW mechanism.

  9. Exploring the impact of socio-technical core-periphery structures in open source software development

    NARCIS (Netherlands)

    Amrit, Chintan Amrit; van Hillegersberg, Jos

    2010-01-01

    In this paper we apply the social network concept of core-periphery structure to the socio-technical structure of a software development team. We propose a socio-technical pattern that can be used to locate emerging coordination problems in Open Source projects. With the help of our tool and method

  10. R. S. Peters and the Periphery

    Science.gov (United States)

    Haynes, Bruce

    2013-01-01

    Paul Hirst claimed that Richard Peters "revolutionised philosophy of education". This does not accord with my experience in the Antipodean periphery. My experience of the work of Wittgenstein, Austin and Kovesi before reading Peters and Dewey, Kuhn and Toulmin subsequently meant that Peters was a major but not revolutionary figure in my…

  11. Side event of the coordination office during the EWEA 2011 conference

    International Nuclear Information System (INIS)

    Lapierre, Anne; Toxe, Laurence; Cassin, Fabrice; Doisne, Fabien

    2011-01-01

    At the occasion of the 2011 edition of the Europe Wind energy event (EWEA), the French-German office for Renewable energies (OFAEnR) organised a conference entitled 'Fresh wind in the French regulatory framework'. In the framework of this French-German exchange of experience, participants exchanged views on the new fiscal and legal framework for the wind industry in France and its immediate and future impacts on the development of this industry. This document brings together the available presentations (slides) made during this event: 1 - Wind energy sector: the regulatory framework after 'Grenelle II' Law - Focus on the reform of business tax (Anne Lapierre, Laurence Toxe); 2 - The French planning exercise - Regional Wind Plan (SRe): Perspectives and Reality (Fabrice Cassin); 3 - Regional wind plan approach - Picardie: case study of the drawing up of a Regional Wind Plan (Fabien Doisne)

  12. Supervisory control synthesis of discrete-event systems using a coordination scheme

    Czech Academy of Sciences Publication Activity Database

    Komenda, Jan; Masopust, Tomáš; van Schuppen, J. H.

    2012-01-01

    Roč. 48, č. 2 (2012), s. 247-254 ISSN 0005-1098 R&D Projects: GA ČR(CZ) GAP103/11/0517; GA ČR GPP202/11/P028 Grant - others:European Commission(XE) EU.ICT.DISC 224498 Institutional research plan: CEZ:AV0Z10190503 Keywords : discrete-event systems * supervisory control * distributed control * closed-loop systems * controllability Subject RIV: BA - General Mathematics Impact factor: 2.919, year: 2012 http://www.sciencedirect.com/science/article/pii/S0005109811005395

  13. Supervisory control synthesis of discrete-event systems using a coordination scheme

    Czech Academy of Sciences Publication Activity Database

    Komenda, Jan; Masopust, Tomáš; van Schuppen, J. H.

    2012-01-01

    Roč. 48, č. 2 (2012), s. 247-254 ISSN 0005-1098 R&D Projects: GA ČR(CZ) GAP103/11/0517; GA ČR GPP202/11/P028 Grant - others:European Commission(XE) EU. ICT .DISC 224498 Institutional research plan: CEZ:AV0Z10190503 Keywords : discrete-event systems * supervisory control * distributed control * closed-loop systems * controllability Subject RIV: BA - General Mathematics Impact factor: 2.919, year: 2012 http://www.sciencedirect.com/science/article/pii/S0005109811005395

  14. Behavioral impact of unisensory and multisensory audio-tactile events: pros and cons for interlimb coordination in juggling.

    Directory of Open Access Journals (Sweden)

    Gregory Zelic

    Full Text Available Recent behavioral neuroscience research revealed that elementary reactive behavior can be improved in the case of cross-modal sensory interactions thanks to underlying multisensory integration mechanisms. Can this benefit be generalized to an ongoing coordination of movements under severe physical constraints? We choose a juggling task to examine this question. A central issue well-known in juggling lies in establishing and maintaining a specific temporal coordination among balls, hands, eyes and posture. Here, we tested whether providing additional timing information about the balls and hands motions by using external sound and tactile periodic stimulations, the later presented at the wrists, improved the behavior of jugglers. One specific combination of auditory and tactile metronome led to a decrease of the spatiotemporal variability of the juggler's performance: a simple sound associated to left and right tactile cues presented antiphase to each other, which corresponded to the temporal pattern of hands movement in the juggling task. A contrario, no improvements were obtained in the case of other auditory and tactile combinations. We even found a degraded performance when tactile events were presented alone. The nervous system thus appears able to integrate in efficient way environmental information brought by different sensory modalities, but only if the information specified matches specific features of the coordination pattern. We discuss the possible implications of these results for the understanding of the neuronal integration process implied in audio-tactile interaction in the context of complex voluntary movement, and considering the well-known gating effect of movement on vibrotactile perception.

  15. Behavioral Impact of Unisensory and Multisensory Audio-Tactile Events: Pros and Cons for Interlimb Coordination in Juggling

    Science.gov (United States)

    Zelic, Gregory; Mottet, Denis; Lagarde, Julien

    2012-01-01

    Recent behavioral neuroscience research revealed that elementary reactive behavior can be improved in the case of cross-modal sensory interactions thanks to underlying multisensory integration mechanisms. Can this benefit be generalized to an ongoing coordination of movements under severe physical constraints? We choose a juggling task to examine this question. A central issue well-known in juggling lies in establishing and maintaining a specific temporal coordination among balls, hands, eyes and posture. Here, we tested whether providing additional timing information about the balls and hands motions by using external sound and tactile periodic stimulations, the later presented at the wrists, improved the behavior of jugglers. One specific combination of auditory and tactile metronome led to a decrease of the spatiotemporal variability of the juggler's performance: a simple sound associated to left and right tactile cues presented antiphase to each other, which corresponded to the temporal pattern of hands movement in the juggling task. A contrario, no improvements were obtained in the case of other auditory and tactile combinations. We even found a degraded performance when tactile events were presented alone. The nervous system thus appears able to integrate in efficient way environmental information brought by different sensory modalities, but only if the information specified matches specific features of the coordination pattern. We discuss the possible implications of these results for the understanding of the neuronal integration process implied in audio-tactile interaction in the context of complex voluntary movement, and considering the well-known gating effect of movement on vibrotactile perception. PMID:22384211

  16. Bridge-builder in the periphery

    DEFF Research Database (Denmark)

    Leick, Birgit; Gretzinger, Susanne

    (Virkkala 2007) and a prevalence of SMEs in niche-focused or traditional sectors (De Noronha Vaz et al. 2006; Copus et al. 2008), and, as a result, low rates of innovation and entrepreneurial activities (Labrianidis 2006; Stathoupoulou et al. 2004; Ritsäla 1999; Tödtling and Trippl 2005; Danson and De Souza...... in the periphery through enhancing inter-firm networking and networked innovativeness (Burdack et al. 2013; Tregear and Cooper 2016). We call such actors “bridge-builder”, alluding to their capacity to connect local communities of business-owners and entrepreneurs, public-policy representatives and civic actors...

  17. Industrial Catching Up in the Poor Periphery 1870-1975

    OpenAIRE

    Jeffrey G. Williamson

    2011-01-01

    This paper documents industrial output and labor productivity growth around the poor periphery 1870-1975 (Latin America, the European periphery, the Middle East, South Asia, Southeast Asia and East Asia). Intensive and extensive industrial growth accelerated there over this critical century. The precocious poor periphery leaders underwent a surge and more poor countries joined their club. Furthermore, by the interwar the majority were catching up on Germany, the US and the UK, a process that ...

  18. The Critical Periphery in the Growth of Social Protests.

    Science.gov (United States)

    Barberá, Pablo; Wang, Ning; Bonneau, Richard; Jost, John T; Nagler, Jonathan; Tucker, Joshua; González-Bailón, Sandra

    2015-01-01

    Social media have provided instrumental means of communication in many recent political protests. The efficiency of online networks in disseminating timely information has been praised by many commentators; at the same time, users are often derided as "slacktivists" because of the shallow commitment involved in clicking a forwarding button. Here we consider the role of these peripheral online participants, the immense majority of users who surround the small epicenter of protests, representing layers of diminishing online activity around the committed minority. We analyze three datasets tracking protest communication in different languages and political contexts through the social media platform Twitter and employ a network decomposition technique to examine their hierarchical structure. We provide consistent evidence that peripheral participants are critical in increasing the reach of protest messages and generating online content at levels that are comparable to core participants. Although committed minorities may constitute the heart of protest movements, our results suggest that their success in maximizing the number of online citizens exposed to protest messages depends, at least in part, on activating the critical periphery. Peripheral users are less active on a per capita basis, but their power lies in their numbers: their aggregate contribution to the spread of protest messages is comparable in magnitude to that of core participants. An analysis of two other datasets unrelated to mass protests strengthens our interpretation that core-periphery dynamics are characteristically important in the context of collective action events. Theoretical models of diffusion in social networks would benefit from increased attention to the role of peripheral nodes in the propagation of information and behavior.

  19. Cores and peripheries in a northern periphery: a case study in Finland

    Directory of Open Access Journals (Sweden)

    Pekka Kauppila

    2011-01-01

    Full Text Available During the last decades, peripheral rural areas have been faced with social and economic challenges, such as economic restructuring, unemployment, out-migration and ageing population. Due to declining traditional industries, tourism has often been highlighted as a vehicle to revitalize the economy in rural areas. The aim of the review is to conceptualize the regional development process of resorts in relation to their location municipalities at the local level in Finland. GIS (Geographical Information Systems technology and georeferenced data, so called grid data, are utilized in the statistical socio-economic analysis of the four largest resorts – Levi, Ruka, Saariselkä and Ylläs – in the Finnish periphery. The study results show that the development process of the resorts has been very positive in terms of the indicators of regional development. Along with the absolute progressing, the relative importance of the resorts within their location municipalities has strengthened. The outcome of the study is presented in the classic core–periphery framework: the resorts are considered as cores and the surrounding area of those cores as a periphery. In consequence, there emerges a polarization process within the municipalities under study because of tourism development. It is obvious that the role of the resorts within the location municipalities in regional development will strengthen in the future. Generally speaking, from the viewpoint of the regional development of peripheral rural areas, the main challenge is to extend the positive socio-economic impacts of resorts, cores, to a wider geographical area, a periphery.

  20. Learning English in the Periphery: A View from Myanmar (Burma)

    Science.gov (United States)

    Tin, Tan Bee

    2014-01-01

    Although researchers have called for the investigation of local vernacular learning and teaching practices in various ELT (English language teaching) contexts, studies conducted in the Periphery are fewer in number. This study attempts to understand English learning experiences of a group of students from the Periphery, who were studying English…

  1. Strategic sourcing: from periphery to the core.

    Science.gov (United States)

    Gottfredson, Mark; Puryear, Rudy; Phillips, Stephen

    2005-02-01

    As globalization changes the basis of competition, sourcing is moving from the periphery of corporate functions to the core. Always important in terms of costs, sourcing is becoming a strategic opportunity. But few companies are ready for this shift. Outsourcing has grown so sophisticated that even critical functions like engineering, R&D, manufacturing, and marketing can-and often should-be moved outside. And that, in turn, is changing the way companies think about their organizations, their value chains, and their competitive positions. Already, a handful of vanguard companies are transforming what used to be purely internal corporate functions into entirely new industries. Companies like UPS, Solectron, and Hewitt have created new business models by concentrating scale and skill within a single function. As these and other function-based companies grow, so does the potential value of outsourcing to all companies. Migrating from a vertically integrated company to a specialized provider of a single function is not a winning strategy for everyone. But all companies need to rigorously reassess each of their functions as possible outsourcing candidates. Presented in this article is a simple three-step process to identify which functions your company needs to own and protect, which can be best performed by what kinds of partners, and which could be turned into new business opportunities. The result of such an analysis will be a comprehensive capabilities-sourcing strategy. As a detailed examination of 7-Eleven's experience shows, the success of the strategy often hinges on the creativity with which partnerships are organized and managed. But only by first taking a broad, strategic view of capabilities sourcing can your company gain the greatest benefit from all of its sourcing choices.

  2. An event-related potential investigation of the acute effects of aerobic and coordinative exercise on inhibitory control in children with ADHD

    Directory of Open Access Journals (Sweden)

    Sebastian Ludyga

    2017-12-01

    Full Text Available The current body of evidence suggests that an aerobic exercise session has a beneficial effect on inhibitory control, whereas the impact of coordinative exercise on this executive function has not yet been examined in children with ADHD. Therefore, the present study aims to investigate the acute effects of aerobic and coordinative exercise on behavioral performance and the allocation of attentional resources in an inhibitory control task.Using a cross-over design, children with ADHD-combined type and healthy comparisons completed a Flanker task before and after 20 min moderately-intense cycling exercise, coordinative exercise and an inactive control condition. During the task, stimulus-locked event-related potentials were recorded with electroencephalography.Both groups showed an increase of P300 amplitude and decrease of reaction time after exercise compared to the control condition. Investigating the effect of exercise modality, aerobic exercise led to greater increases of P300 amplitude and reductions in reaction time than coordinative exercise in children with ADHD.The findings suggest that a single exercise bout improves inhibitory control and the allocation of attentional resources. There were some indications that an aerobic exercise session seems to be more efficient than coordinative exercise in reducing the inhibitory control deficits that persist in children with ADHD. Keywords: P300, Executive function, Cognitive performance, Flanker task, Development, Healthy children

  3. Effective components of nurse-coordinated care to prevent recurrent coronary events: a systematic review and meta-analysis

    NARCIS (Netherlands)

    Snaterse, Marjolein; Dobber, Jos; Jepma, Patricia; Peters, Ron J. G.; ter Riet, Gerben; Boekholdt, S. Matthijs; Buurman, Bianca M.; Scholte op Reimer, Wilma J. M.

    2016-01-01

    Current guidelines on secondary prevention of cardiovascular disease recommend nurse-coordinated care (NCC) as an effective intervention. However, NCC programmes differ widely and the efficacy of NCC components has not been studied. To investigate the efficacy of NCC and its components in secondary

  4. Centre and Periphery in the Linear B Archives

    DEFF Research Database (Denmark)

    Nosch, Marie-Louise Bech

    2003-01-01

    Investigation of the perception of space and geographi in the Bronze Age administration. Three concepts are occuring: palace versus territory; province A versus province B; Centrum versus periphery....

  5. Coordinated research programme on safety of RBMK type NPPs in relation to external events. V. 1. Working material

    International Nuclear Information System (INIS)

    1999-01-01

    The present volume is a collection of progress reports which have been submitted within the scope of the CRP on safety of RBMK type NPPs in relation to external events including seismic related papers and man-induced events (explosions and airplane crash). It includes papers concerned with experience related to RBMK equipment testing and calculations of seismic resistance, soil-structure interactions analysis, safety assurance, aircraft impact qualification and other external events for RBMK type NPP, seismic stability of NPPs in Eastern Europe, probabilistic assessment of NPP safety under aircraft impact, dynamic analysis of NPPs, screening of external hazards for NPP

  6. Side event from the Coordination office at Warsaw: Latest developments on the French Wind Power Market: New rules, new challenges

    International Nuclear Information System (INIS)

    Cassin, Fabrice; Elfassi, Paul; Froeding, Veronique; Petit, Jean-Francois

    2010-01-01

    At the occasion of the 2010 edition of the European Wind energy Conference (EWEC 2010), the French-German office for Renewable energies (OFAEnR) organised a Side event on the latest developments of the French Wind Power Market. This document brings together the available presentations (slides) made during this event: 1 - The new regulatory framework under the 'Grenelle' laws: Wind energy planning. French National Action Plan: the wind energy challenge (Fabrice Cassin); 2 - The upcoming enforcement of the dangerous installations rules (ICPe) to wind power plants (Veronique Froeding); 3 - New tax system for wind energy projects and local acceptance (Jean-Francois Petit)

  7. Events

    Directory of Open Access Journals (Sweden)

    Igor V. Karyakin

    2016-02-01

    Full Text Available The 9th ARRCN Symposium 2015 was held during 21st–25th October 2015 at the Novotel Hotel, Chumphon, Thailand, one of the most favored travel destinations in Asia. The 10th ARRCN Symposium 2017 will be held during October 2017 in the Davao, Philippines. International Symposium on the Montagu's Harrier (Circus pygargus «The Montagu's Harrier in Europe. Status. Threats. Protection», organized by the environmental organization «Landesbund für Vogelschutz in Bayern e.V.» (LBV was held on November 20-22, 2015 in Germany. The location of this event was the city of Wurzburg in Bavaria.

  8. Coordinating Interactions: The Event Coordination Notation

    DEFF Research Database (Denmark)

    Kindler, Ekkart

    models fully automatically with today’s technologies. The focus of today’s code generation technologies, however, is mostly on the structural aspects of the domain; the domain’s behaviour is often not modelled at all, or implemented manually based on some informal models, or the behaviour is modelled...... for the local and the global behaviour define the overall behaviour of the domain. In this technical report, we discuss the main idea and philosophy of ECNO and its notation as well as all the subtle details and concepts - and we motivate the decisions made for its design. Moreover, we discuss the prototypical...... implementation of ECNO, which consists of a modelling environment based on Eclipse and the Eclipse Modeling Framework (EMF) and an execution engine, which fully supports all the concepts and features of ECNO discussed in this technical report. All the examples are based on EMF, but the ECNO Engine can be used...

  9. Center-Periphery Bargaining in the Age of Democracy

    DEFF Research Database (Denmark)

    Siroky, David; Mueller, Sean; Hechter, Michael Norman

    2016-01-01

    This paper introduces the key concepts used in this special issue – center, periphery, and vertical bargaining – and inquires why some national groups within democratic states demand outright independence, while others mobilize for regional autonomy and still others settle for even less. It then ......This paper introduces the key concepts used in this special issue – center, periphery, and vertical bargaining – and inquires why some national groups within democratic states demand outright independence, while others mobilize for regional autonomy and still others settle for even less...

  10. Loss of co-ordinate expression of progesterone receptors A and B is an early event in breast carcinogenesis.

    Science.gov (United States)

    Mote, P A; Bartow, S; Tran, N; Clarke, C L

    2002-03-01

    Progesterone receptor (PR) mediates the effects of progesterone in mammary tissues and plays a crucial role in normal breast development and in breast cancer. PR proteins are expressed as two isoforms, PRA and PRB, that have different capacities to activate target genes, yet it is unknown whether progesterone action in normal and malignant breast is mediated by PRA and/or PRB. This study determines the relative expression of PRA and PRB in normal breast and in benign, premalignant and malignant archival breast lesions by dual immunofluorescent histochemistry. In normal breast and in proliferative disease without atypia (PDWA) PRA and PRB were co-expressed within the same cells in comparable amounts, implicating both isoforms in progesterone action. In atypical lesions, however, there was a significant increase in predominant expression of PRA or PRB, with lesion progression from the normal state to malignancy. PR isoform predominance, especially PRA predominance, was evident in a high proportion of ductal carcinomas in situ (DCIS) and invasive breast lesions. In the normal breast and in PDWA, the relative expression of PRA and PRB in adjacent cells was homogenous. There was a significant increase in cell-to-cell heterogeneity of PR isoform expression in ADH and DCIS lesions and in the majority of breast cancers. Heterogeneous cell-to-cell expression of PR isoforms occurred prior to overall predominant expression of one isoform in premalignant breast lesions, demonstrating that loss of control of relative PRA:PRB expression is an early event in the development of breast cancer. PRA:PRB ratios within a breast lesion are likely to be important as both markers and effectors of tumor growth and development, and progressively aberrant PR isoform expression may play a role in the etiology of breast cancer.

  11. Multijunction grill response to ponderomotive effects at plasma periphery

    International Nuclear Information System (INIS)

    Hurtak, O.; Klima, R.; Petrzilka, V.A.

    1990-10-01

    A nonlinear coupling code taking account of ponderomotive force effects at the plasma periphery, was developed for a multijunction grill. With increasing RF power density the power reflection coefficient remains rather low at the frequency of 4.6 GHz this at the expense of deterioration of the power distribution among subsidiary waveguides. The ensuing danger of overloading the individual waveguides is expected to be still greater for lower frequencies. (author)

  12. Recovery of Corneal Endothelial Cells from Periphery after Injury.

    Directory of Open Access Journals (Sweden)

    Sang Ouk Choi

    Full Text Available Wound healing of the endothelium occurs through cell enlargement and migration. However, the peripheral corneal endothelium may act as a cell resource for the recovery of corneal endothelium in endothelial injury.To investigate the recovery process of corneal endothelial cells (CECs from corneal endothelial injury.Three patients with unilateral chemical eye injuries, and 15 rabbit eyes with corneal endothelial chemical injuries were studied. Slit lamp examination, specular microscopy, and ultrasound pachymetry were performed immediately after chemical injury and 1, 3, 6, and 9 months later. The anterior chambers of eyes from New Zealand white rabbits were injected with 0.1 mL of 0.05 N NaOH for 10 min (NaOH group. Corneal edema was evaluated at day 1, 7, and 14. Vital staining was performed using alizarin red and trypan blue.Specular microscopy did not reveal any corneal endothelial cells immediately after injury. Corneal edema subsided from the periphery to the center, CEC density increased, and central corneal thickness decreased over time. In the animal study, corneal edema was greater in the NaOH group compared to the control at both day 1 and day 7. At day 1, no CECs were detected at the center and periphery of the corneas in the NaOH group. Two weeks after injury, small, hexagonal CECs were detected in peripheral cornea, while CECs in mid-periphery were large and non-hexagonal.CECs migrated from the periphery to the center of the cornea after endothelial injury. The peripheral corneal endothelium may act as a cell resource for the recovery of corneal endothelium.

  13. Centrality metrics and localization in core-periphery networks

    International Nuclear Information System (INIS)

    Barucca, Paolo; Lillo, Fabrizio; Tantari, Daniele

    2016-01-01

    Two concepts of centrality have been defined in complex networks. The first considers the centrality of a node and many different metrics for it have been defined (e.g. eigenvector centrality, PageRank, non-backtracking centrality, etc). The second is related to large scale organization of the network, the core-periphery structure, composed by a dense core plus an outlying and loosely-connected periphery. In this paper we investigate the relation between these two concepts. We consider networks generated via the stochastic block model, or its degree corrected version, with a core-periphery structure and we investigate the centrality properties of the core nodes and the ability of several centrality metrics to identify them. We find that the three measures with the best performance are marginals obtained with belief propagation, PageRank, and degree centrality, while non-backtracking and eigenvector centrality (or MINRES [10], showed to be equivalent to the latter in the large network limit) perform worse in the investigated networks. (paper: interdisciplinary statistical mechanics )

  14. Disentangling bipartite and core-periphery structure in financial networks

    International Nuclear Information System (INIS)

    Barucca, Paolo; Lillo, Fabrizio

    2016-01-01

    A growing number of systems are represented as networks whose architecture conveys significant information and determines many of their properties. Examples of network architecture include modular, bipartite, and core-periphery structures. However inferring the network structure is a non trivial task and can depend sometimes on the chosen null model. Here we propose a method for classifying network structures and ranking its nodes in a statistically well-grounded fashion. The method is based on the use of Belief Propagation for learning through Entropy Maximization on both the Stochastic Block Model (SBM) and the degree-corrected Stochastic Block Model (dcSBM). As a specific application we show how the combined use of the two ensembles—SBM and dcSBM—allows to disentangle the bipartite and the core-periphery structure in the case of the e-MID interbank network. Specifically we find that, taking into account the degree, this interbank network is better described by a bipartite structure, while using the SBM the core-periphery structure emerges only when data are aggregated for more than a week.

  15. [Pain information pathways from the periphery to the cerebral cortex].

    Science.gov (United States)

    Kuroda, Ryotaro; Kawabata, Atsufumi

    2003-07-01

    A recent PET study revealed that the first and second somatosensory cortices (SI, SII), and the anterior cingulate cortex are activated by painful peripheral stimulation in humans. It has become clear that painful signals (nociceptive information) evoked at the periphery are transmitted via various circuits to the multiple cerebral cortices where pain signals are processed and perceived. Human or clinical pain is not merely a modality of somatic sensation, but associated with the affect that accompanies sensation. Consequently, pain has a somatosensory-discriminative aspect and an affective-cognitive aspect that are processed in different but correlated brain structures in the ascending circuits. Considering the physiologic characteristics and fiber connections, the SI and SII cortices appear to be involved in somatosensory-discriminative pain, and the anterior cingulate cortex (area 24) in the affective-cognitive aspect of pain. This paper deals with the ascending pain pathways from the periphery to these cortices and their interconnections. Our recent findings on the protease-activated receptors 1 and 2 (PAR-1, and -2), which are confirmed to exist in the dorsal root ganglion cells, are also described. Activation of PAR-2 during inflammation or tissue injury at the periphery is pronociceptive, while PAR-1 appears to be antinociceptive. Based on the these findings, PAR-1 and PAR-2 are attracting interest as target molecules for new drug development.

  16. Multiarm spirals on the periphery of disc galaxies

    Science.gov (United States)

    Lubov, Spiegel; Evgeny, Polyachenko

    2018-04-01

    Spiral patterns in some disc galaxies have two arms in the centre, and three or more arms on the periphery. The same result is also obtained in numerical simulations of stellar and gaseous discs.We argue that such patterns may occur due to fast cooling of the gas, resulting in formation of giant molecular clouds. The timescale of this process is 50 Myr, the factor of 10 shorter than of ordinary secular instability. The giant molecular clouds give rise to multiarm spirals through the mechanism of swing amplification.

  17. Eruptive history of Mammoth Mountain and its mafic periphery, California

    Science.gov (United States)

    Hildreth, Wes; Fierstein, Judy

    2016-07-13

    This report and accompanying geologic map portray the eruptive history of Mammoth Mountain and a surrounding array of contemporaneous volcanic units that erupted in its near periphery. The moderately alkaline Mammoth eruptive suite, basaltic to rhyodacitic, represents a discrete new magmatic system, less than 250,000 years old, that followed decline of the subalkaline rhyolitic system active beneath adjacent Long Valley Caldera since 2.2 Ma (Hildreth, 2004). The scattered vent array of the Mammoth system, 10 by 20 km wide, is unrelated to the rangefront fault zone, and its broad nonlinear footprint ignores both Long Valley Caldera and the younger Mono-Inyo rangefront vent alignment.

  18. Odor memories regulate olfactory receptor expression in the sensory periphery.

    Science.gov (United States)

    Claudianos, Charles; Lim, Julianne; Young, Melanie; Yan, Shanzhi; Cristino, Alexandre S; Newcomb, Richard D; Gunasekaran, Nivetha; Reinhard, Judith

    2014-05-01

    Odor learning induces structural and functional modifications throughout the olfactory system, but it is currently unknown whether this plasticity extends to the olfactory receptors (Or) in the sensory periphery. Here, we demonstrate that odor learning induces plasticity in olfactory receptor expression in the honeybee, Apis mellifera. Using quantitative RT-PCR analysis, we show that six putative floral scent receptors were differentially expressed in the bee antennae depending on the scent environment that the bees experienced. Or151, which we characterized using an in vitro cell expression system as a broadly tuned receptor binding floral odorants such as linalool, and Or11, the specific receptor for the queen pheromone 9-oxo-decenoic acid, were significantly down-regulated after honeybees were conditioned with the respective odorants in an olfactory learning paradigm. Electroantennogram recordings showed that the neural response of the antenna was similarly reduced after odor learning. Long-term odor memory was essential for inducing these changes, suggesting that the molecular mechanisms involved in olfactory memory also regulate olfactory receptor expression. Our study demonstrates for the first time that olfactory receptor expression is experience-dependent and modulated by scent conditioning, providing novel insight into how molecular regulation at the periphery contributes to plasticity in the olfactory system. © 2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  19. Kadavu Island: adaptation and stagnation in the Fijian periphery

    Directory of Open Access Journals (Sweden)

    Sofer Michael

    2015-06-01

    Full Text Available The outer island of Kadavu is representative of the Fijian periphery. This paper deals with its physical characteristics, infrastructural conditions, and village economic activities with the aim of understanding the changes it has gone through in recent years. A combination of micro-geographic studies in two villages and a meso-geographical analysis show that the pattern of development found in Kadavu in the early 1980s has not changed much. The current pattern of cash crop production and trade is almost entirely dependent on the kava beverage crop, infrastructure is underdeveloped, the island suffers from the peripheral penalty phenomenon, and government initiatives aimed at changing the trend are very limited. However, the current form of non-capitalist production and its derived benefit has forced villagers into a strategy of adaptation which might actually be preferable for them under the current conditions of peripheralization.

  20. Financial Transmission Mechanism between Financial Centers and Peripheries

    Directory of Open Access Journals (Sweden)

    Yuki Masujima

    2014-08-01

    Full Text Available The  causes  of  contagion  effects  during  periods  of  crisis  are  still  unable  to  be  fully explained  by  fundamental  factors.  This  paper  focuses  on  non-fundamental  explanatory factors  such  as  inancial  centers'  shock  ampliication  effects  induced  by  global  portfolio investors  and  extends  Kaminsky  and  Reinhart  (2003's  center-periphery  framework  by introducing three time zones for the analysis of conditional distribution of 37 countries' daily stock returns from 1994 to 2003, and accessibility of stock markets to investigate if inancial centers stabilize or amplify shocks. Centers such as U.S. and Germany played a vital role in propagating turmoil in G7 countries and spreading shocks to countries in other regions during periods of crisis, whereas Japan ampliied turmoil in Asian peripheries only within the same region. In contrast, an emerging center, Hong Kong, appears to have much stronger shock-ampliication effects on developing countries than the three centers.  ";} // -->activate javascript

  1. PERIPHERY/CORE RELATIONS IN THE INCA EMPIRE CARROTS AND STICKS IN AN ANDEAN WORLD SYSTEM

    OpenAIRE

    Lawrence A. Kuznar

    2015-01-01

    The Inca Empire exhibited labor exploitation and the rational extraction of resources from peripheral polities by a core polity. These characteristics fit the general definition of a world empire, although core/periphery relations were diverse. The nature of core/periphery relations depended on several attributes of the conquered polity including population size, political power, natural resources, and distance from the Inca core at Cuzco. A dynamic picture of core/periphery relations emerges...

  2. Memory and Forgetting on the National Periphery: Marseilles and the Regicide of 1934

    Directory of Open Access Journals (Sweden)

    Matthew Graves

    2010-05-01

    Full Text Available The assassination of the King of Yugoslavia, Alexander Ist by Croatian terrorists during a state visit to Marseilles on 9 October 1934 is commemorated by a modest plaque on the Canebière and a little known monument outside the Préfecture. Although the histories of the period cite the event in passing, it is treated as a footnote in the political history of France and has been all but erased from the memory of the city. While there are good reasons for forgetting the episode – regicide does no favours for the reputation of a host nation or city and the French Foreign Minister Louis Barthou was accidentally shot by the French police – the double killing had multiple ramifications for France's interior and foreign affairs during the rise of fascism in Europe. It advanced the career of future Vichy Prime Minister Pierre Laval, who replaced Barthou as Foreign Minister, while French efforts to contain the threat of German expansionism by forging alliances with the Central European powers died with Barthou; King Alexander Ist's successor moved Yugoslavia into the camp of the Axis powers. Geopolitically, the system of collective security forged at Versailles collapsed in the wake the assassination. The incident in Marseilles highlights political tensions in France in the troubled inter-war years leading up to the emergence of the Front Populaire. It reveals the memorial agencies of core and periphery engaged in a struggle over the rights to remembrance. Above all, it poses the problem of the preservation of peripheral and traumatic episodes in collective memory and suggests that political violence constitutes a social periphery of its own, contributing to Marseille's "mauvaise réputation" as the French capital's negative, meridional 'other'.

  3. Precise localization of metal nanoparticles in dendrimer nanosnakes or inner periphery and consequences in catalysis

    Science.gov (United States)

    Liu, Xiang; Gregurec, Danijela; Irigoyen, Joseba; Martinez, Angel; Moya, Sergio; Ciganda, Roberto; Hermange, Philippe; Ruiz, Jaime; Astruc, Didier

    2016-10-01

    Understanding the relationship between the location of nanoparticles (NPs) in an organic matrix and their catalytic performances is essential for catalyst design. Here we show that catalytic activities of Au, Ag and CuNPs stabilized by dendrimers using coordination to intradendritic triazoles, galvanic replacement or stabilization outside dendrimers strongly depends on their location. AgNPs are found at the inner click dendrimer periphery, whereas CuNPs and AuNPs are encapsulated in click dendrimer nanosnakes. AuNPs and AgNPs formed by galvanic replacement are larger than precursors and only partly encapsulated. AuNPs are all the better 4-nitrophenol reduction catalysts as they are less sterically inhibited by the dendrimer interior, whereas on the contrary CuNPs are all the better alkyne azide cycloaddition catalysts as they are better protected from aerobic oxidation inside dendrimers. This work highlights the role of the location in macromolecules on the catalytic efficiency of metal nanoparticles and rationalizes optimization in catalyst engineering.

  4. Center-periphery management in the internationalization of executive masters

    Directory of Open Access Journals (Sweden)

    Ana Christina Celano Teixeira

    2018-03-01

    Full Text Available This article analyzes the process of internationalization of the International Masters Program for Managers (IMPM started in 2012 from a partnership established with a Brazilian institution. Created in 1995 by Henry Mintzberg – also the current director – the IMPM adopted a heterodox model challenging the US traditional MBA model, Mintzberg’s moto “Managers, Not MBA” suggests a new focus on managers instead of overemphasizing analysis and technique. From a critical perspective, this study identifies that, although proposing an appreciation of the culture of the different places where the international modules are hosted, the IMPM still adopts the Anglo-Saxon logic of knowledge imposition. The study reflects the expectation that, when considering the internationalization of management educational programs, from a critical point of view, the voices of peripheral countries are heard, promoting a better balance between the production and consumption of knowledge on management in the contemporary global context. It is necessary, therefore, to work in order to create a more dialogical movement between center and periphery, establishing a dynamic that considers not only cultural aspects, but also that recognizes the production of knowledge in both contexts.

  5. Unveiling the Low Surface Brightness Stellar Peripheries of Galaxies

    Science.gov (United States)

    Ferguson, Annette M. N.

    2018-01-01

    The low surface brightness peripheral regions of galaxies contain a gold mine of information about how minor mergers and accretions have influenced their evolution over cosmic time. Enormous stellar envelopes and copious amounts of faint tidal debris are natural outcomes of the hierarchical assembly process and the search for and study of these features, albeit highly challenging, offers the potential for unrivalled insight into the mechanisms of galaxy growth. Over the last two decades, there has been burgeoning interest in probing galaxy outskirts using resolved stellar populations. Wide-field surveys have uncovered vast tidal debris features and new populations of very remote globular clusters, while deep Hubble Space Telescope photometry has provided exquisite star formation histories back to the earliest epochs. I will highlight some recent results from studies within and beyond the Local Group and conclude by briefly discussing the great potential of future facilities, such as JWST, Euclid, LSST and WFIRST, for major breakthroughs in low surface brightness galaxy periphery science.

  6. Botulinum toxin's axonal transport from periphery to the spinal cord.

    Science.gov (United States)

    Matak, Ivica; Riederer, Peter; Lacković, Zdravko

    2012-07-01

    Axonal transport of enzymatically active botulinum toxin A (BTX-A) from periphery to the CNS has been described in facial and trigeminal nerve, leading to cleavage of synaptosomal-associated protein 25 (SNAP-25) in central nuclei. Aim of present study was to examine the existence of axonal transport of peripherally applied BTX-A to spinal cord via sciatic nerve. We employed BTX-A-cleaved SNAP-25 immunohistochemistry of lumbar spinal cord after intramuscular and subcutaneous hind limb injections, and intraneural BTX-A sciatic nerve injections. Truncated SNAP-25 in ipsilateral spinal cord ventral horns and dorsal horns appeared after single peripheral BTX-A administrations, even at low intramuscular dose applied (5 U/kg). Cleaved SNAP-25 appearance in the spinal cord after BTX-A injection into the sciatic nerve was prevented by proximal intrasciatic injection of colchicine (5 mM, 2 μl). Cleaved SNAP-25 in ventral horn, using choline-acetyltransferase (ChAT) double labeling, was localized within cholinergic neurons. These results extend the recent findings on BTX-A retrograde axonal transport in facial and trigeminal nerve. Appearance of truncated SNAP-25 in spinal cord following low-dose peripheral BTX-A suggest that the axonal transport of BTX-A occurs commonly following peripheral application. Copyright © 2012 Elsevier Ltd. All rights reserved.

  7. Interdisciplinary and transdisciplinary institutions: do they constitute peripheries among cultures?

    Energy Technology Data Exchange (ETDEWEB)

    Vienni, B.; Vilsmaier, U.

    2016-07-01

    The paper presents the progress done in the project entitled “Challenges in interdisciplinary and transdisciplinary knowledge production: institutions, cultures and communities”. This research investigates challenges of interdisciplinary (ID) and transdisciplinary (TD) knowledge production, focusing on processes of institutionalization, cultural transformations and the characteristics of communities. The starting points for this research are two universities that have tackled the challenge of incorporating ID and TD in their institutional structure and study programs: the Center of Methods (Leuphana University Lüneburg, Germany) and the Espacio Interdisciplinario (Universidad de la República, Uruguay) (UdelaR). The conclusions are not closed only to Germany and Uruguay – but compared to other examples to draw a general model to describe answer the question addressed in this paper as well as to assess ID and TD institutions and to systematize learning in terms of fostering and hindering factors for ID institutionalization. This seeks to epistemic cultures that allow a defined identity based on those features of ID and TD evaluated as general enough to be valid in the German and Uruguayan academic contexts and not only in peripheries. In this sense, we want to contribute to the methodological and theoretical construction of what it can be named “Studies on Interdisciplinarity” in Uruguay and Latin America. (Author)

  8. Effects of Exercise Intervention on Event-Related Potential and Task Performance Indices of Attention Networks in Children with Developmental Coordination Disorder

    Science.gov (United States)

    Tsai, Chia-Liang; Wang, Chun-Hao; Tseng, Yu-Ting

    2012-01-01

    The study investigated whether 10-week soccer training can benefit the inhibitory control and neuroelectric indices in children with developmental coordination disorder (DCD). Fifty-one children were divided into groups of typically developing (TD, n = 21), DCD-training (n = 16), and DCD non-training (n=14) individuals using the for Children test,…

  9. The functional role of the periphery in emotional language comprehension

    Directory of Open Access Journals (Sweden)

    David A. Havas

    2013-05-01

    Full Text Available Language can impact emotion, even when it makes no reference to emotion states. For example, reading sentences with positive meanings (The water park is refreshing on the hot summer day induces patterns of facial feedback congruent with the sentence emotionality (smiling, whereas sentences with negative meanings induce a frown. Moreover, blocking facial afference with botox selectively slows comprehension of emotional sentences. Therefore, theories of cognition should account for emotion-language interactions above the level of explicit emotion words, and the role of peripheral feedback in comprehension. For this special issue exploring frontiers in the role of the body and environment in cognition, we propose a theory in which facial feedback provides a context-sensitive constraint on the simulation of actions described in language. Paralleling the role of emotions in real-world behavior, our account proposes that 1 facial expressions accompany sudden shifts in well-being as described in language; 2 facial expressions modulate emotion states during reading; and 3 emotion states prepare the reader for an effective simulation of the ensuing language content. To inform the theory and guide future research, we outline a framework based on internal models for motor control. To support the theory, we assemble evidence from diverse areas of research. Taking a functional view of emotion, we tie the theory to behavioral and neural evidence for a role of facial feedback in cognition. Our theoretical framework provides a detailed account that can guide future research on the role of emotional feedback in language processing, and on interactions of language and emotion. It also highlights the bodily periphery as relevant to theories of embodied cognition.

  10. PERIPHERY/CORE RELATIONS IN THE INCA EMPIRE CARROTS AND STICKS IN AN ANDEAN WORLD SYSTEM

    Directory of Open Access Journals (Sweden)

    Lawrence A. Kuznar

    2015-08-01

    Full Text Available The Inca Empire exhibited labor exploitation and the rational extraction of resources from peripheral polities by a core polity. These characteristics fit the general definition of a world empire, although core/periphery relations were diverse. The nature of core/periphery relations depended on several attributes of the conquered polity including population size, political power, natural resources, and distance from the Inca core at Cuzco. A dynamic picture of core/periphery relations emerges as the outcome of Inca demands for labor and raw materials, and peripheral peoples' desire for control over their autonomy while seeking benefits from the Inca state.

  11. Coordinated Cluster, ground-based instrumentation and low-altitude satellite observations of transient poleward-moving events in the ionosphere and in the tail lobe

    Directory of Open Access Journals (Sweden)

    M. Lockwood

    Full Text Available During the interval between 8:00–9:30 on 14 January 2001, the four Cluster spacecraft were moving from the central magnetospheric lobe, through the dusk sector mantle, on their way towards intersecting the magnetopause near 15:00 MLT and 15:00 UT. Throughout this interval, the EISCAT Svalbard Radar (ESR at Longyearbyen observed a series of poleward-moving transient events of enhanced F-region plasma concentration ("polar cap patches", with a repetition period of the order of 10 min. Allowing for the estimated solar wind propagation delay of 75 ( ± 5 min, the interplanetary magnetic field (IMF had a southward component during most of the interval. The magnetic footprint of the Cluster spacecraft, mapped to the ionosphere using the Tsyganenko T96 model (with input conditions prevailing during this event, was to the east of the ESR beams. Around 09:05 UT, the DMSP-F12 satellite flew over the ESR and showed a sawtooth cusp ion dispersion signature that also extended into the electrons on the equatorward edge of the cusp, revealing a pulsed magnetopause reconnection. The consequent enhanced ionospheric flow events were imaged by the SuperDARN HF backscatter radars. The average convection patterns (derived using the AMIE technique on data from the magnetometers, the EISCAT and SuperDARN radars, and the DMSP satellites show that the associated poleward-moving events also convected over the predicted footprint of the Cluster spacecraft. Cluster observed enhancements in the fluxes of both electrons and ions. These events were found to be essentially identical at all four spacecraft, indicating that they had a much larger spatial scale than the satellite separation of the order of 600 km. Some of the events show a correspondence between the lowest energy magnetosheath electrons detected by the PEACE instrument on Cluster (10–20 eV and the topside ionospheric enhancements seen by the ESR (at 400–700 km. We suggest that a potential barrier at the

  12. Coordinated Cluster, ground-based instrumentation and low-altitude satellite observations of transient poleward-moving events in the ionosphere and in the tail lobe

    Directory of Open Access Journals (Sweden)

    M. Lockwood

    2001-09-01

    Full Text Available During the interval between 8:00–9:30 on 14 January 2001, the four Cluster spacecraft were moving from the central magnetospheric lobe, through the dusk sector mantle, on their way towards intersecting the magnetopause near 15:00 MLT and 15:00 UT. Throughout this interval, the EISCAT Svalbard Radar (ESR at Longyearbyen observed a series of poleward-moving transient events of enhanced F-region plasma concentration ("polar cap patches", with a repetition period of the order of 10 min. Allowing for the estimated solar wind propagation delay of 75 ( ± 5 min, the interplanetary magnetic field (IMF had a southward component during most of the interval. The magnetic footprint of the Cluster spacecraft, mapped to the ionosphere using the Tsyganenko T96 model (with input conditions prevailing during this event, was to the east of the ESR beams. Around 09:05 UT, the DMSP-F12 satellite flew over the ESR and showed a sawtooth cusp ion dispersion signature that also extended into the electrons on the equatorward edge of the cusp, revealing a pulsed magnetopause reconnection. The consequent enhanced ionospheric flow events were imaged by the SuperDARN HF backscatter radars. The average convection patterns (derived using the AMIE technique on data from the magnetometers, the EISCAT and SuperDARN radars, and the DMSP satellites show that the associated poleward-moving events also convected over the predicted footprint of the Cluster spacecraft. Cluster observed enhancements in the fluxes of both electrons and ions. These events were found to be essentially identical at all four spacecraft, indicating that they had a much larger spatial scale than the satellite separation of the order of 600 km. Some of the events show a correspondence between the lowest energy magnetosheath electrons detected by the PEACE instrument on Cluster (10–20 eV and the topside ionospheric enhancements seen by the ESR (at 400–700 km. We suggest that a potential barrier at the

  13. Poisson Coordinates.

    Science.gov (United States)

    Li, Xian-Ying; Hu, Shi-Min

    2013-02-01

    Harmonic functions are the critical points of a Dirichlet energy functional, the linear projections of conformal maps. They play an important role in computer graphics, particularly for gradient-domain image processing and shape-preserving geometric computation. We propose Poisson coordinates, a novel transfinite interpolation scheme based on the Poisson integral formula, as a rapid way to estimate a harmonic function on a certain domain with desired boundary values. Poisson coordinates are an extension of the Mean Value coordinates (MVCs) which inherit their linear precision, smoothness, and kernel positivity. We give explicit formulas for Poisson coordinates in both continuous and 2D discrete forms. Superior to MVCs, Poisson coordinates are proved to be pseudoharmonic (i.e., they reproduce harmonic functions on n-dimensional balls). Our experimental results show that Poisson coordinates have lower Dirichlet energies than MVCs on a number of typical 2D domains (particularly convex domains). As well as presenting a formula, our approach provides useful insights for further studies on coordinates-based interpolation and fast estimation of harmonic functions.

  14. Toxoplasma gondii chromodomain protein 1 binds to heterochromatin and colocalises with centromeres and telomeres at the nuclear periphery.

    Directory of Open Access Journals (Sweden)

    Mathieu Gissot

    Full Text Available BACKGROUND: Apicomplexan parasites are responsible for some of the most deadly parasitic diseases afflicting humans, including malaria and toxoplasmosis. These obligate intracellular parasites exhibit a complex life cycle and a coordinated cell cycle-dependant expression program. Their cell division is a coordinated multistep process. How this complex mechanism is organised remains poorly understood. METHODS AND FINDINGS: In this study, we provide evidence for a link between heterochromatin, cell division and the compartmentalisation of the nucleus in Toxoplasma gondii. We characterised a T. gondii chromodomain containing protein (named TgChromo1 that specifically binds to heterochromatin. Using ChIP-on-chip on a genome-wide scale, we report TgChromo1 enrichment at the peri-centromeric chromatin. In addition, we demonstrate that TgChromo1 is cell-cycle regulated and co-localised with markers of the centrocone. Through the loci-specific FISH technique for T. gondii, we confirmed that TgChromo1 occupies the same nuclear localisation as the peri-centromeric sequences. CONCLUSION: We propose that TgChromo1 may play a role in the sequestration of chromosomes at the nuclear periphery and in the process of T. gondii cell division.

  15. Emission and null coordinates: geometrical properties and physical construction

    International Nuclear Information System (INIS)

    Coll, Bartolome; Ferrando, Joan J; Morales-Lladosa, Juan A

    2011-01-01

    A Relativistic Positioning System is defined by four clocks (emitters) broadcasting their proper time. Then, every event reached by the signals is naturally labeled by these four times which are the emission coordinates of this event. The coordinate hypersurfaces of the emission coordinates are the future light cones based on the emitter trajectories. For this reason the emission coordinates have been also named null coordinates or light coordinates. Nevertheless, other coordinate systems used in different relativistic contexts have the own right to be named null or light coordinates. Here we analyze when one can say that a coordinate is a null coordinate and when one can say that a coordinate system is null. Moreover, we examine the physical construction and the geometrical properties of several n ull coordinate systems : the emission and the reception coordinates, the radar coordinates, and the Bondi-Sachs coordinates, among others.

  16. Spatial coordinate systems for tactile spatial attention depend on developmental vision: evidence from event-related potentials in sighted and congenitally blind adult humans.

    Science.gov (United States)

    Röder, Brigitte; Föcker, Julia; Hötting, Kirsten; Spence, Charles

    2008-08-01

    Changes in limb posture (such as crossing the hands) can impair people's performance in tasks such as those involving temporal order judgements, when one tactile stimulus is presented to either hand. This crossed hands deficit has been attributed to a conflict between externally and anatomically anchored reference systems when people localize tactile stimuli. Interestingly, however, the performance of congenitally blind adults does not seem to be affected by crossing the hands, suggesting a default use of an anatomically rather than an externally anchored reference system for tactile localization. In the present study, 12 congenitally blind and 12 sighted adults were instructed to attend to either the left or the right hand on a trial-by-trial basis in order to detect rare deviants (consisting of a double touch) at that hand, while ignoring both deviants at the other hand and frequent standard stimuli (consisting of a single touch) presented to either hand. Only the sighted participants performed less accurately when they crossed their hands. Concurrent electroencephalogram recordings revealed an early contralateral attention positivity, followed by an attention negativity in the sighted group when they adopted the uncrossed hands posture. For the crossed hand posture, only the attention negativity was observed with reduced amplitude in the sighted group. By contrast, the congenitally blind group displayed an event-related potential attention negativity that did not vary when the posture of their hands was changed. These results demonstrate that the default use of an external frame of reference for tactile localization seems to depend on developmental vision.

  17. Resilience of Core-Periphery Networks in the Case of Rich-Club

    Directory of Open Access Journals (Sweden)

    Matteo Cinelli

    2017-01-01

    Full Text Available Core-periphery networks are structures that present a set of central and densely connected nodes, namely, the core, and a set of noncentral and sparsely connected nodes, namely, the periphery. The rich-club refers to a set in which the highest degree nodes show a high density of connections. Thus, a network that displays a rich-club can be interpreted as a core-periphery network in which the core is made up of a number of hubs. In this paper, we test the resilience of networks showing a progressively denser rich-club and we observe how this structure is able to affect the network measures in terms of both cohesion and efficiency in information flow. Additionally, we consider the case in which, instead of making the core denser, we add links to the periphery. These two procedures of core and periphery thickening delineate a decision process in the placement of new links and allow us to conduct a scenario analysis that can be helpful in the comprehension and supervision of complex networks under the resilience perspective. The advantages of the two procedures, as well as their implications, are discussed in relation to both network efficiency and node heterogeneity.

  18. Coordination cycles

    Czech Academy of Sciences Publication Activity Database

    Steiner, Jakub

    -, č. 274 (2005), s. 1-26 ISSN 1211-3298 Institutional research plan: CEZ:AV0Z70850503 Keywords : coordination * crises * cycles and fluctuations Subject RIV: AH - Economics http://www.cerge-ei.cz/pdf/wp/Wp274.pdf

  19. Coordination cycles

    Czech Academy of Sciences Publication Activity Database

    Steiner, Jakub

    2008-01-01

    Roč. 63, č. 1 (2008), s. 308-327 ISSN 0899-8256 Institutional research plan: CEZ:AV0Z70850503 Keywords : global games * coordination * crises * cycles and fluctuations Subject RIV: AH - Economics Impact factor: 1.333, year: 2008

  20. Coordination of glioblastoma cell motility by PKCι

    Directory of Open Access Journals (Sweden)

    Baldwin R Mitchell

    2010-09-01

    Full Text Available Abstract Background Glioblastoma is one of the deadliest forms of cancer, in part because of its highly invasive nature. The tumor suppressor PTEN is frequently mutated in glioblastoma and is known to contribute to the invasive phenotype. However the downstream events that promote invasion are not fully understood. PTEN loss leads to activation of the atypical protein kinase C, PKCι. We have previously shown that PKCι is required for glioblastoma cell invasion, primarily by enhancing cell motility. Here we have used time-lapse videomicroscopy to more precisely define the role of PKCι in glioblastoma. Results Glioblastoma cells in which PKCι was either depleted by shRNA or inhibited pharmacologically were unable to coordinate the formation of a single leading edge lamellipod. Instead, some cells generated multiple small, short-lived protrusions while others generated a diffuse leading edge that formed around the entire circumference of the cell. Confocal microscopy showed that this behavior was associated with altered behavior of the cytoskeletal protein Lgl, which is known to be inactivated by PKCι phosphorylation. Lgl in control cells localized to the lamellipod leading edge and did not associate with its binding partner non-muscle myosin II, consistent with it being in an inactive state. In PKCι-depleted cells, Lgl was concentrated at multiple sites at the periphery of the cell and remained in association with non-muscle myosin II. Videomicroscopy also identified a novel role for PKCι in the cell cycle. Cells in which PKCι was either depleted by shRNA or inhibited pharmacologically entered mitosis normally, but showed marked delays in completing mitosis. Conclusions PKCι promotes glioblastoma motility by coordinating the formation of a single leading edge lamellipod and has a role in remodeling the cytoskeleton at the lamellipod leading edge, promoting the dissociation of Lgl from non-muscle myosin II. In addition PKCι is required

  1. TECHNICAL COORDINATION

    CERN Multimedia

    A. Ball

    Overview From a technical perspective, CMS has been in “beam operation” state since 6th November. The detector is fully closed with all components operational and the magnetic field is normally at the nominal 3.8T. The UXC cavern is normally closed with the radiation veto set. Access to UXC is now only possible during downtimes of LHC. Such accesses must be carefully planned, documented and carried out in agreement with CMS Technical Coordination, Experimental Area Management, LHC programme coordination and the CCC. Material flow in and out of UXC is now strictly controlled. Access to USC remains possible at any time, although, for safety reasons, it is necessary to register with the shift crew in the control room before going down.It is obligatory for all material leaving UXC to pass through the underground buffer zone for RP scanning, database entry and appropriate labeling for traceability. Technical coordination (notably Stephane Bally and Christoph Schaefer), the shift crew and run ...

  2. Capitalism Reborn, Chaos and the Post-Socialist Freefall: A View from Europe's "New Periphery"

    Science.gov (United States)

    Templer, Bill

    2014-01-01

    The present paper--from a vantage in Bulgaria, and focusing in significant part on this country as an iconic example of the "post-socialist freefall' and its dystopia on European capitalism's neocolonial "new periphery"--is a revised version of an earlier chapter in "Immiseration Capitalism and Education: Austerity, Resistance…

  3. The formation of a core-periphery structure in heterogeneous financial networks

    NARCIS (Netherlands)

    van der Leij, M.; in 't Veld, D.; Hommes, C.

    2016-01-01

    Recent empirical evidence suggests that financial networks exhibit a core-periphery network structure. This paper aims at giving an explanation for the emergence of such a structure using network formation theory. We propose a simple model of the overnight interbank lending market, in which banks

  4. Bit by Bit: Innovating at the Periphery to Extend Harvard's Core

    Science.gov (United States)

    Laserna, Catalina; Leitner, Henry

    2008-01-01

    Faculty instructional time is a critical resource at all universities, but particularly in a major research institution like Harvard. Operating on the periphery of the Faculty of Arts and Sciences, Harvard's division of Continuing Education is often at a disadvantage when attempting to recruit senior faculty. However, through its distance…

  5. What's the Place of Queer Theory in Studies of Gender, Sexuality, and Education on the Periphery?

    Science.gov (United States)

    Rasmussen, Mary Lou

    2016-01-01

    This article is an exploration of the problem of theorizing gender and sexuality of people who Raewyn Connell might describe as coming from the global periphery, but whose lives and futures are also enmeshed in the politics, policies, and pedagogies of the metropole. Elizabeth Povinelli has done extensive research on Indigenous people in the…

  6. Visualizing the molecular sociology at the HeLa cell nuclear periphery

    NARCIS (Netherlands)

    Mahamid, Julia; Pfeffer, Stefan; Schaffer, Miroslava; Villa, Elizabeth; Danev, Radostin; Cuellar, Luis Kuhn; Förster, Friedrich|info:eu-repo/dai/nl/412516438; Hyman, Anthony A; Plitzko, Jürgen M; Baumeister, Wolfgang

    2016-01-01

    The molecular organization of eukaryotic nuclear volumes remains largely unexplored. Here we combined recent developments in cryo-electron tomography (cryo-ET) to produce three-dimensional snapshots of the HeLa cell nuclear periphery. Subtomogram averaging and classification of ribosomes revealed

  7. Rethinking centres and peripheries in the Enlightenment: toward a global history of science

    NARCIS (Netherlands)

    Roberts, Lissa L.

    2012-01-01

    This essay begins with a focus on how centre-periphery relations have been construed by historians of science since the middle of the twentieth century. It then suggests an alternative view of the historically embedded networks within which knowledge has circulated. Instead of adopting an a priori

  8. Task-based core-periphery organization of human brain dynamics.

    Directory of Open Access Journals (Sweden)

    Danielle S Bassett

    Full Text Available As a person learns a new skill, distinct synapses, brain regions, and circuits are engaged and change over time. In this paper, we develop methods to examine patterns of correlated activity across a large set of brain regions. Our goal is to identify properties that enable robust learning of a motor skill. We measure brain activity during motor sequencing and characterize network properties based on coherent activity between brain regions. Using recently developed algorithms to detect time-evolving communities, we find that the complex reconfiguration patterns of the brain's putative functional modules that control learning can be described parsimoniously by the combined presence of a relatively stiff temporal core that is composed primarily of sensorimotor and visual regions whose connectivity changes little in time and a flexible temporal periphery that is composed primarily of multimodal association regions whose connectivity changes frequently. The separation between temporal core and periphery changes over the course of training and, importantly, is a good predictor of individual differences in learning success. The core of dynamically stiff regions exhibits dense connectivity, which is consistent with notions of core-periphery organization established previously in social networks. Our results demonstrate that core-periphery organization provides an insightful way to understand how putative functional modules are linked. This, in turn, enables the prediction of fundamental human capacities, including the production of complex goal-directed behavior.

  9. Coordinating controls

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1986-07-15

    While physics Laboratories are having to absorb cuts in resources, the machines they rely on are becoming more and more complex, requiring increasingly sophisticated systems. Rather than being a resourceful engineer or physicist able to timber together solutions in his 'backyard', the modern controls specialist has become a professional in his own right. Because of possible conflicts between increasing sophistication on one hand and scarcer resources on the other, there was felt a need for more contacts among controls specialists to exchange experiences, coordinate development and discuss 'family problems', away from meetings where the main interest is on experimental physics.

  10. Coordinated unbundling

    DEFF Research Database (Denmark)

    Timmermans, Bram; Zabala-Iturriagagoitia, Jon Mikel

    2013-01-01

    Public procurement for innovation is a matter of using public demand to trigger innovation. Empirical studies have demonstrated that demand-based policy instruments can be considered to be a powerful tool in stimulating innovative processes among existing firms; however, the existing literature has...... not focused on the role this policy instrument can play in the promotion of (knowledge-intensive) entrepreneurship. This paper investigates this link in more detail and introduces the concept of coordinated unbundling as a strategy that can facilitate this purpose. We also present a framework on how...

  11. Coordinating controls

    International Nuclear Information System (INIS)

    Anon.

    1986-01-01

    While physics Laboratories are having to absorb cuts in resources, the machines they rely on are becoming more and more complex, requiring increasingly sophisticated systems. Rather than being a resourceful engineer or physicist able to timber together solutions in his 'backyard', the modern controls specialist has become a professional in his own right. Because of possible conflicts between increasing sophistication on one hand and scarcer resources on the other, there was felt a need for more contacts among controls specialists to exchange experiences, coordinate development and discuss 'family problems', away from meetings where the main interest is on experimental physics

  12. ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity.

    Science.gov (United States)

    Daley, William P; Gervais, Elise M; Centanni, Samuel W; Gulfo, Kathryn M; Nelson, Deirdre A; Larsen, Melinda

    2012-01-01

    The basement membrane is crucial for epithelial tissue organization and function. However, the mechanisms by which basement membrane is restricted to the basal periphery of epithelial tissues and the basement membrane-mediated signals that regulate coordinated tissue organization are not well defined. Here, we report that Rho kinase (ROCK) controls coordinated tissue organization by restricting basement membrane to the epithelial basal periphery in developing mouse submandibular salivary glands, and that ROCK inhibition results in accumulation of ectopic basement membrane throughout the epithelial compartment. ROCK-regulated restriction of PAR-1b (MARK2) localization in the outer basal epithelial cell layer is required for basement membrane positioning at the tissue periphery. PAR-1b is specifically required for basement membrane deposition, as inhibition of PAR-1b kinase activity prevents basement membrane deposition and disrupts overall tissue organization, and suppression of PAR-1b together with ROCK inhibition prevents interior accumulations of basement membrane. Conversely, ectopic overexpression of wild-type PAR-1b results in ectopic interior basement membrane deposition. Significantly, culture of salivary epithelial cells on exogenous basement membrane rescues epithelial organization in the presence of ROCK1 or PAR-1b inhibition, and this basement membrane-mediated rescue requires functional integrin β1 to maintain epithelial cell-cell adhesions. Taken together, these studies indicate that ROCK1/PAR-1b-dependent regulation of basement membrane placement is required for the coordination of tissue polarity and the elaboration of tissue structure in the developing submandibular salivary gland.

  13. TECHNICAL COORDINATION

    CERN Multimedia

    A. Ball

    2010-01-01

    Operational Experience At the end of the first full-year running period of LHC, CMS is established as a reliable, robust and mature experiment. In particular common systems and infrastructure faults accounted for <0.6 % CMS downtime during LHC pp physics. Technical operation throughout the entire year was rather smooth, the main faults requiring UXC access being sub-detector power systems and rack-cooling turbines. All such problems were corrected during scheduled technical stops, in the shadow of tunnel access needed by the LHC, or in negotiated accesses or access extensions. Nevertheless, the number of necessary accesses to the UXC averaged more than one per week and the technical stops were inevitably packed with work packages, typically 30 being executed within a few days, placing a high load on the coordination and area management teams. It is an appropriate moment for CMS Technical Coordination to thank all those in many CERN departments and in the Collaboration, who were involved in CMS techni...

  14. Challenges to the Israeli healthcare system: attracting medical students to primary care and to the periphery.

    Science.gov (United States)

    Weissman, Charles; Zisk-Rony, Rachel Yaffa; Avidan, Alexander; Elchalal, Uriel; Tandeter, Howard

    2018-05-29

    The greatest challenges facing healthcare systems include ensuring a sufficient supply of primary care physicians and physicians willing to work in rural or peripheral areas. Especially challenging is enticing young physicians to practice primary care in rural/peripheral areas. Identifying medical students interested in primary care and in residencies in Israel's periphery should aid the healthcare leadership. It may be particularly important to do so during the clinical years, as this is the stage at which many future physicians begin to crystallize their specialty and location preferences. Questionnaires, distributed to 6 consecutive 5th-year classes of the Hebrew University - Hadassah School of Medicine, from 2010 to 2016, elicited information on criteria for choosing a career specialty, criteria for choosing a residency program and whether one-time monetary grants authorized in the 2011 physicians' union contract would attract students to residencies in the periphery. Completed questionnaires were returned by 511 of 740 (69%) students. Ninety-eight (19%) were interested in a primary care residency, 184 (36%) were unsure and 229 (45%) were not interested. Students interested in primary care were significantly less interested in specialties that perform procedures/surgeries and in joining a medical school faculty, while being more inclined towards specialties dealing with social problems, controllable lifestyles and working limited hours. The percentage of students interested in primary care was stable during the study period. Forty-eight of the students indicated interest in residencies in the country's periphery, and 42% of them were also interested in primary care residencies. Overall, only 3.7% of students were interested in both a primary care residency and a residency in the periphery. Thirty percent of the students indicated that the monetary incentives tempted them to consider a residency in the periphery. Fifty-three percent of these students reported

  15. Solution of the 'MIDICORE' WWER-1000 core periphery power distribution benchmark by KARATE and MCNP

    International Nuclear Information System (INIS)

    Temesvari, E.; Hegyi, G.; Hordosy, G.; Maraczy, C.

    2011-01-01

    The 'MIDICORE' WWER-1000 core periphery power distribution benchmark was proposed by Mr. Mikolas on the twentieth Symposium of AER in Finland in 2010. This MIDICORE benchmark is a two-dimensional calculation benchmark based on the WWER-1000 reactor core cold state geometry with taking into account the geometry of explicit radial reflector. The main task of the benchmark is to test the pin by pin power distribution in selected fuel assemblies at the periphery of the WWER-1000 core. In this paper we present our results (k eff , integral fission power) calculated by MCNP and the KARATE code system in KFKI-AEKI and the comparison to the preliminary reference Monte Carlo calculation results made by NRI, Rez. (Authors)

  16. “Getting By” at the Urban Periphery: Everyday Struggles of Informal Merchants in Tunisia

    Directory of Open Access Journals (Sweden)

    Johannes Frische

    2015-11-01

    Full Text Available The article examines the significance of informal economic practices, e.g. street vending and informal commerce, for young merchants from Ettadhamen, a neighborhood situated in the northwestern periphery of the Greater Tunis area. It further addresses cross-border trade in the Tunisian-Libyan and Tunisian-Algerian border regions in which some of these merchants are indirectly involved. Peripheralization therefore does not imply complete socio-spatial exclusion. Peripheries rather offer important, albeit limited possibilities, to acquire resources through practices that are situated in the interstices between legality and illegality. As these possibilities often avoid state regulation and control, the article also addresses the ambivalent nature of the state-society relations that shapes everyday encounters between inhabitants and state agents, especially the police.

  17. Glioma Cells in the Tumor Periphery Have a Stem Cell Phenotype

    DEFF Research Database (Denmark)

    Munthe, Sune; Petterson, Stine Asferg; Dahlrot, Rikke Hedegaard

    2016-01-01

    and a panel of markers was used. The panel comprised of six stem cell-related markers (CD133, Musashi-1, Bmi-1, Sox-2, Nestin and Glut-3), a proliferation marker (Ki-67) as well as a chemo-resistance marker (MGMT). Computer-based automated classifiers were designed to measure the mIDH1 positive nucleus area......-fraction of the chosen markers. Moreover, orthotopic glioblastoma xenografts from five different patient-derived spheroid cultures were obtained and the tumor cells identified by human specific immunohistochemical markers. The results showed that tumor cells in the periphery of patient gliomas expressed stem cell...... in the periphery of patient gliomas have a stem cell phenotype, although it is less pronounced than in the tumor core. Novel therapies aiming at preventing recurrence should therefore take tumor stemness into account. Migrating cells in orthotopic glioblastoma xenografts preserve expression and stem cell markers...

  18. Environmentalism in the Periphery: Institutional Embeddedness and Deforestation among Fifteen Palm Oil Producers, 1990 – 2012

    Directory of Open Access Journals (Sweden)

    Kent Henderson

    2017-08-01

    Full Text Available Environmental sociologists highlight the exploitative nature of the global capitalist economy where resource extraction from nations in the periphery tends to disproportionately benefit those of the core. From the Brazilian Amazon to mineral-rich Sub-Saharan Africa, the practice of “unequal ecological exchange” persists. Simultaneously, a “global environmental regime” has coalesced as a prominent feature of the contemporary world system. In the post-World War II era, legitimate nation-states must take steps to protect the natural environment and prevent its degradation even at their own economic expense. Stronger national ties to global institutions, particularly international nongovernmental organizations (INGOs consistently yield more positive environmental outcomes. However, previous work suggests that normative expectations for improved environmental practice will be weak or nonexistent in the periphery. We use the case of palm oil production and its relationship to deforestation to provide a more nuanced analysis of the relationship between material and institutional forces in the periphery. Using unbalanced panels of fifteen palm oil producing countries from 1990 to 2012, we find that stronger national ties to world society via citizen memberships in INGOs result in greater primary forest area among palm oil producers. However, this effect is strongest where production is lowest and weakens as production increases. Even in the cases of Indonesia and Malaysia, where palm oil production is substantially higher than any other producer, ties to global institutions are significantly related to reduced forest loss. These results indicate the variable importance of national embeddedness into global institutions within the periphery of the world system.

  19. Economic development in the European super-periphery: Evidence from the Western Balkans

    OpenAIRE

    Bartlett Will

    2009-01-01

    This paper argues that the conflicts that afflicted the Western Balkan region in the 1990s pushed the countries into the European 'super-periphery', characterized by deindustrialization and high unemployment, ethnic and regional fragmentation, political turmoil, and instability. Integration into international trade has been disrupted, leading to chronic balance of payments deficits. Low inflows of international capital, due to high country risk, have hindered technological catch-up and weaken...

  20. CORPORATE SOCIAL RESPONSIBILITY, A RECOVERY SCHEME IN PERIPHERIES: THE PETRONAS AND CNPC ENTERPRISES IN SUDAN

    OpenAIRE

    ELNAZEER ELTOM SHAAELDIN; MOHD RIZAL MOHD YAKKOP; KAMARUZAMAN YUSOFF; ALI ALWI; AZRAI ABDULLAH

    2013-01-01

    This paper assesses the accuracy and mainly the impact of multinational corporations on performing construction, as well as the basic services supply in fragile social economic conditions in Sudan. It reveals that within Sudan state weakness and poor conditions in peripheries, war zone areas in particular, reflect invasive challenges facing the country, and thus, applying corporations’ helps to meet and increase the supply of public needs and recovery in instable Sudan. Through a qualitative ...

  1. Underestimated Benefits from Periphery: Internal Migration and Subjective Well-being

    OpenAIRE

    Kopmann, Angela; Rehdanz, Katrin

    2014-01-01

    This paper is among the first to link internal migration and subjective well-being in developed countries. Economic theory predicts that individuals migrate towards urban agglomerations, if the potential gain in income is sufficient to cover costs. However, this narrow view cannot explain why migration exists also to the rural periphery. In our analysis, we investigate non-monetary benefits beyond economics from internal migration. Using highly disaggregated spatial information on people s mi...

  2. The terminal region of the E. coli chromosome localises at the periphery of the nucleoid

    Directory of Open Access Journals (Sweden)

    Stouf Mathieu

    2011-02-01

    Full Text Available Abstract Background Bacterial chromosomes are organised into a compact and dynamic structures termed nucleoids. Cytological studies in model rod-shaped bacteria show that the different regions of the chromosome display distinct and specific sub-cellular positioning and choreographies during the course of the cell cycle. The localisation of chromosome loci along the length of the cell has been described. However, positioning of loci across the width of the cell has not been determined. Results Here, we show that it is possible to assess the mean positioning of chromosomal loci across the width of the cell using two-dimension images from wide-field fluorescence microscopy. Observed apparent distributions of fluorescent-tagged loci of the E. coli chromosome along the cell diameter were compared with simulated distributions calculated using a range of cell width positioning models. Using this method, we detected the migration of chromosome loci towards the cell periphery induced by production of the bacteriophage T4 Ndd protein. In the absence of Ndd production, loci outside the replication terminus were located either randomly along the nucleoid width or towards the cell centre whereas loci inside the replication terminus were located at the periphery of the nucleoid in contrast to other loci. Conclusions Our approach allows to reliably observing the positioning of chromosome loci along the width of E. coli cells. The terminal region of the chromosome is preferentially located at the periphery of the nucleoid consistent with its specific roles in chromosome organisation and dynamics.

  3. Revealing a comet-like shape of the faint periphery of the nearby galaxy M 32

    Science.gov (United States)

    Georgiev, Ts. B.

    2016-02-01

    We performed BVRI photometry of the galaxy M 32 building images and isophote maps in magnitudes and in color indexes. While searching for the faint thick disk of M 32 we apply median filtering with aperture of 7.3 arcmin to detach the residual image of M 32 and its periphery above the surrounding magnitude or color background. The residual images in all photometric systems show that the periphery of M 32 possesses a comet-like shape with a tail oriented to SSE, in a direction opposite to the direction of M 110. The images calibrated in color indexes (b - v) and (b - v)+(r - i) show that the tail is redder than the local median background. The residual images in color indexes show that the red tail broadens and curves in direction towards S and SW. Simultaneously, the brightest part of M 32 occurs bounded from NW-NE-SE sides by a sickle-like formation with a significantly lower red color index. Generally, we do not find a faint thick disk of M 32. However, the comet-like shape on the periphery of M 32, especially as a formation with an increased red color index, provokes involuntarily the impression that the satellite M 32 overtakes the Andromeda galaxy. The redshifts show that the intimacy velocity of M 32 and Andromeda galaxy is about 100 km/s.

  4. Culture, innovation and periphery: a theoretical sketch and some evidence from different portuguese contexts

    Directory of Open Access Journals (Sweden)

    Eduardo Brito Henriques

    1997-11-01

    Full Text Available The present paper tries to look at the culture-innovation nexus in periphery. Starting with a theoretical discussion on this issue, in which the role of culture in current capitalism is analysed, we raise the question whether the increasing imporance of culture in the present economic context has been creating new opportunities for peripheral regions to innovate, namely by the valorization of tradition.The paper will highlight the results of four case studies from the handicraft pottery sector. These achievements will then be confronted with an exemple of cultural political promotion in an urban area - Lisbon'94, European Cultural Capital, in order to unravel the political logic of cultural and innovation in the periphery. The final section provides a brief conclusion, placing emphasis on the ambivalences which characterise peripherical modernisation processes and their cultural dimension. We argue that the ability of periphery to sustain development strategies based on the valorization of tradition depends primarily upon a successful management of these ambivalences.

  5. RUN COORDINATION

    CERN Multimedia

    Christophe Delaere

    2013-01-01

    The focus of Run Coordination during LS1 is to monitor closely the advance of maintenance and upgrade activities, to smooth interactions between subsystems and to ensure that all are ready in time to resume operations in 2015 with a fully calibrated and understood detector. After electricity and cooling were restored to all equipment, at about the time of the last CMS week, recommissioning activities were resumed for all subsystems. On 7 October, DCS shifts began 24/7 to allow subsystems to remain on to facilitate operations. That culminated with the Global Run in November (GriN), which   took place as scheduled during the week of 4 November. The GriN has been the first centrally managed operation since the beginning of LS1, and involved all subdetectors but the Pixel Tracker presently in a lab upstairs. All nights were therefore dedicated to long stable runs with as many subdetectors as possible. Among the many achievements in that week, three items may be highlighted. First, the Strip...

  6. RUN COORDINATION

    CERN Multimedia

    C. Delaere

    2013-01-01

    Since the LHC ceased operations in February, a lot has been going on at Point 5, and Run Coordination continues to monitor closely the advance of maintenance and upgrade activities. In the last months, the Pixel detector was extracted and is now stored in the pixel lab in SX5; the beam pipe has been removed and ME1/1 removal has started. We regained access to the vactank and some work on the RBX of HB has started. Since mid-June, electricity and cooling are back in S1 and S2, allowing us to turn equipment back on, at least during the day. 24/7 shifts are not foreseen in the next weeks, and safety tours are mandatory to keep equipment on overnight, but re-commissioning activities are slowly being resumed. Given the (slight) delays accumulated in LS1, it was decided to merge the two global runs initially foreseen into a single exercise during the week of 4 November 2013. The aim of the global run is to check that we can run (parts of) CMS after several months switched off, with the new VME PCs installed, th...

  7. Rehabitar la Montaña: strategies and processes for sustainable communities in the mountainous periphery of Medellín

    Directory of Open Access Journals (Sweden)

    Joseph Claghorn

    2016-01-01

    Full Text Available Thousands of poor, marginal communities’ residents die due to landslide events every year. The quick urbanization of mountainous areas, combined with an increased frequency of landslide events induced by heavy rains due to climate change, is leading to increased deaths year after year, and the problem will only get worse. Landscape Architects, trained to analyze and intervene in situations with complex natural and social territorial dynamics, are in position to make positive contributions to mitigating risks in such situations. A collaborative effort between a team of landscape architects from Germany and Urbanists in Medellín Colombia is carrying out a four-phased research and implementation proposal to anticipate and mitigate risk in low-income settlements on Medellín’s urban periphery. They propose five pilot projects to test risk mitigation strategies through monitoring and early warning systems, drainage improvements, urban agriculture, slope forestation, and developing sites with the supplied services.

  8. Paradoxes of Democracy and Depoliticisation in the Social Peripheries of Modernity

    Directory of Open Access Journals (Sweden)

    Gianpasquale Preite

    2018-01-01

    Full Text Available At the end of the 20th Century, the global diffusion of economic neoliberalism represents, seen from diverse perspectives, the outcome of a communicative overlapping between the economic system and the political system. This overlapping is equivalent to a functional intrasparency, which generates paradoxes of democracy as the depoliticisation and exclusion phenomena when facing inclusion expectations, as occurs in the peripheries of the world. Depoliticisation, in fact, appears as a paradox of democratic systems closely related to the development of the technocratic practices and the enhancement of the bureaucratic apparatus. One of the characteristics of technocracy is that it lies on the assumption that great decisions are of technical nature, not political. If great decisions may be taken by means of technical instruments, it means that there is no longer need for 'professional politicians', and even less need for people's participation. Technocracy and burocracy converge above the traditional sphere reserved to politics. The consequence of this convergence is, in fact, depoliticisation. In other words, there is a relation between technocracy, burocracy and ideological crises. Hence, the more technical the decision-making process, the more burocratized will the process of power be, and the more deideologized will the process of fundamental choices be. Populist movements thus describe the effect of the attempt of providing responses to the issues of modern society, to the extent in which the economic value becomes the only discriminating variable between what is correct and what is wrong (what is economically pointless must be discarded and it actually move the decisional process away from the political sphere, enhancing the differences between the center and the periphery, between inclusion and exclusion. In the light of such trends, which have become extensively resilient in the systems, how can the process of functional specification of

  9. The crossover from collective motion to periphery diffusion for two-dimensional adatom-islands on Cu(111)

    International Nuclear Information System (INIS)

    Karim, Altaf; Kara, Abdelkader; Rahman, Talat S; Trushin, Oleg

    2011-01-01

    The diffusion of two-dimensional adatom-islands (up to 100 atoms) on Cu(111) has been studied, using the self-learning kinetic Monte Carlo method (Trushin et al 2005 Phys. Rev. B 72 115401). A variety of multiple- and single-atom processes are revealed in the simulations, and the size dependences of the diffusion coefficients and effective diffusion barriers are calculated for each. From the tabulated frequencies of events found in the simulation, we show a crossover from diffusion due to the collective motion of the island to a regime in which the island diffuses through periphery-dominated mass transport. This crossover occurs for island sizes between 13 and 19 atoms. For islands containing 19-100 atoms the scaling exponent is 1.5, which is in good agreement with previous work. The diffusion of islands containing 2-13 atoms can be explained primarily on the basis of a linear increase of the barrier for the collective motion with the size of the island. (fast track communication)

  10. Keep Meaning in Conversational Coordination

    Directory of Open Access Journals (Sweden)

    Elena Clare Cuffari

    2014-12-01

    Full Text Available Coordination is a widely employed term across recent quantitative and qualitative approaches to intersubjectivity, particularly approaches that give embodiment and enaction central explanatory roles. With a focus on linguistic and bodily coordination in conversational contexts, I review the operational meaning of coordination in recent empirical research and related theorizing of embodied intersubjectivity. This discussion articulates what must be involved in treating linguistic meaning as dynamic processes of coordination. The coordination approach presents languaging as a set of dynamic self-organizing processes and actions on multiple timescales and across multiple modalities that come about and work in certain domains (those jointly constructed in social, interactive, high-order sense-making. These processes go beyond meaning at the level that is available to first-person experience. I take one crucial consequence of this to be the ubiquitously moral nature of languaging with others. Languaging coordinates experience, among other levels of behavior and event. Ethical effort is called for by the automatic autonomy-influencing forces of languaging as coordination.

  11. Epstein-Barr virus thymidine kinase is a centrosomal resident precisely localized to the periphery of centrioles.

    Science.gov (United States)

    Gill, Michael B; Kutok, Jeffery L; Fingeroth, Joyce D

    2007-06-01

    The thymidine kinase (TK) encoded by Epstein-Barr virus (EBV) differs not only from that of the alphaherpesviruses but also from that of the gamma-2 herpesvirus subfamily. Because cellular location is frequently a determinant of regulatory function, to gain insight into additional role(s) of EBV TK and to uncover how the lymphocryptovirus and rhadinovirus enzymes differ, the subcellular localizations of EBV TK and the related cercopithecine herpesvirus-15 TK were investigated. We show that in contrast to those of the other family members, the gamma-1 herpesvirus TKs localize to the centrosome and even more precisely to the periphery of the centriole, tightly encircling the tubulin-rich centrioles in a microtubule-independent fashion. Centrosomal localization is observed in diverse cell types and occurs whether the protein is expressed independently or in the context of lytic EBV infection. Surprisingly, analysis of mutants revealed that the unique N-terminal domain was not critical for targeting to the centrosome, but rather, peptide sequences located C terminal to this domain were key. This is the first herpesvirus protein documented to reside in the centrosome, or microtubule-organizing center, an amembranous organelle that regulates the structural biology of the cell cycle through control of chromosome separation and cytokinesis. More recently, proteasome-mediated degradation of cell cycle regulatory proteins, production and loading of antigenic peptides onto HLA molecules, and transient homing of diverse virion proteins required for entry and/or egress have been shown to be coordinated at the centrosome. Potential implications of centrosomal localization for EBV TK function are discussed.

  12. RUN COORDINATION

    CERN Multimedia

    Christophe Delaere

    2012-01-01

      On Wednesday 14 March, the machine group successfully injected beams into LHC for the first time this year. Within 48 hours they managed to ramp the beams to 4 TeV and proceeded to squeeze to β*=0.6m, settings that are used routinely since then. This brought to an end the CMS Cosmic Run at ~Four Tesla (CRAFT), during which we collected 800k cosmic ray events with a track crossing the central Tracker. That sample has been since then topped up to two million, allowing further refinements of the Tracker Alignment. The LHC started delivering the first collisions on 5 April with two bunches colliding in CMS, giving a pile-up of ~27 interactions per crossing at the beginning of the fill. Since then the machine has increased the number of colliding bunches to reach 1380 bunches and peak instantaneous luminosities around 6.5E33 at the beginning of fills. The average bunch charges reached ~1.5E11 protons per bunch which results in an initial pile-up of ~30 interactions per crossing. During the ...

  13. Treat the brain and treat the periphery: toward a holistic approach to major depressive disorder.

    Science.gov (United States)

    Zheng, Xiao; Zhang, Xueli; Wang, Guangji; Hao, Haiping

    2015-05-01

    The limited medication for major depressive disorder (MDD) against an ever-rising disease burden presents an urgent need for therapeutic innovations. During recent years, studies looking at the systems regulation of mental health and disease have shown a remarkably powerful control of MDD by systemic signals. Meanwhile, the identification of a host of targets outside the brain opens the way to treat MDD by targeting systemic signals. We examine these emerging findings and consider the implications for current thinking regarding MDD pathogenesis and treatment. We highlight the opportunities and challenges of a periphery-targeting strategy and propose its incorporation into a holistic approach. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Transverse current at the periphery of the start plasma of the AMBAL-M open device

    International Nuclear Information System (INIS)

    Taskaev, S.Yu.

    1999-01-01

    Essential longitudinal electron current was experimentally detected earlier in a start plasma of AMBAL-M open trap and system. This paper studies the current at a plasma periphery and the process resulting in occurrence of transverse current, and determines the value of a transverse current in a transporting range. This study enables to determine that filling of a trap with a thin circular flow and formation of nonequilibrium distribution of a radial electrical field in a plasma by potentials of an electrode front gun are the indium peculiarities of the experiment ensuring essential transverse current [ru

  15. Canada's neglected tropical disease research network: who's in the core-who's on the periphery?

    Directory of Open Access Journals (Sweden)

    Kaye Phillips

    Full Text Available This study designed and applied accessible yet systematic methods to generate baseline information about the patterns and structure of Canada's neglected tropical disease (NTD research network; a network that, until recently, was formed and functioned on the periphery of strategic Canadian research funding.MULTIPLE METHODS WERE USED TO CONDUCT THIS STUDY, INCLUDING: (1 a systematic bibliometric procedure to capture archival NTD publications and co-authorship data; (2 a country-level "core-periphery" network analysis to measure and map the structure of Canada's NTD co-authorship network including its size, density, cliques, and centralization; and (3 a statistical analysis to test the correlation between the position of countries in Canada's NTD network ("k-core measure" and the quantity and quality of research produced.Over the past sixty years (1950-2010, Canadian researchers have contributed to 1,079 NTD publications, specializing in Leishmania, African sleeping sickness, and leprosy. Of this work, 70% of all first authors and co-authors (n = 4,145 have been Canadian. Since the 1990s, however, a network of international co-authorship activity has been emerging, with representation of researchers from 62 different countries; largely researchers from OECD countries (e.g. United States and United Kingdom and some non-OECD countries (e.g. Brazil and Iran. Canada has a core-periphery NTD international research structure, with a densely connected group of OECD countries and some African nations, such as Uganda and Kenya. Sitting predominantly on the periphery of this research network is a cluster of 16 non-OECD nations that fall within the lowest GDP percentile of the network.The publication specialties, composition, and position of NTD researchers within Canada's NTD country network provide evidence that while Canadian researchers currently remain the overall gatekeepers of the NTD research they generate; there is opportunity to leverage

  16. Density-based and transport-based core-periphery structures in networks.

    Science.gov (United States)

    Lee, Sang Hoon; Cucuringu, Mihai; Porter, Mason A

    2014-03-01

    Networks often possess mesoscale structures, and studying them can yield insights into both structure and function. It is most common to study community structure, but numerous other types of mesoscale structures also exist. In this paper, we examine core-periphery structures based on both density and transport. In such structures, core network components are well-connected both among themselves and to peripheral components, which are not well-connected to anything. We examine core-periphery structures in a wide range of examples of transportation, social, and financial networks-including road networks in large urban areas, a rabbit warren, a dolphin social network, a European interbank network, and a migration network between counties in the United States. We illustrate that a recently developed transport-based notion of node coreness is very useful for characterizing transportation networks. We also generalize this notion to examine core versus peripheral edges, and we show that the resulting diagnostic is also useful for transportation networks. To examine the properties of transportation networks further, we develop a family of generative models of roadlike networks. We illustrate the effect of the dimensionality of the embedding space on transportation networks, and we demonstrate that the correlations between different measures of coreness can be very different for different types of networks.

  17. A hardware model of the auditory periphery to transduce acoustic signals into neural activity

    Directory of Open Access Journals (Sweden)

    Takashi eTateno

    2013-11-01

    Full Text Available To improve the performance of cochlear implants, we have integrated a microdevice into a model of the auditory periphery with the goal of creating a microprocessor. We constructed an artificial peripheral auditory system using a hybrid model in which polyvinylidene difluoride was used as a piezoelectric sensor to convert mechanical stimuli into electric signals. To produce frequency selectivity, the slit on a stainless steel base plate was designed such that the local resonance frequency of the membrane over the slit reflected the transfer function. In the acoustic sensor, electric signals were generated based on the piezoelectric effect from local stress in the membrane. The electrodes on the resonating plate produced relatively large electric output signals. The signals were fed into a computer model that mimicked some functions of inner hair cells, inner hair cell–auditory nerve synapses, and auditory nerve fibers. In general, the responses of the model to pure-tone burst and complex stimuli accurately represented the discharge rates of high-spontaneous-rate auditory nerve fibers across a range of frequencies greater than 1 kHz and middle to high sound pressure levels. Thus, the model provides a tool to understand information processing in the peripheral auditory system and a basic design for connecting artificial acoustic sensors to the peripheral auditory nervous system. Finally, we discuss the need for stimulus control with an appropriate model of the auditory periphery based on auditory brainstem responses that were electrically evoked by different temporal pulse patterns with the same pulse number.

  18. Economic development in the European super-periphery: Evidence from the Western Balkans

    Directory of Open Access Journals (Sweden)

    Bartlett Will

    2009-01-01

    Full Text Available This paper argues that the conflicts that afflicted the Western Balkan region in the 1990s pushed the countries into the European 'super-periphery', characterized by deindustrialization and high unemployment, ethnic and regional fragmentation, political turmoil, and instability. Integration into international trade has been disrupted, leading to chronic balance of payments deficits. Low inflows of international capital, due to high country risk, have hindered technological catch-up and weakened international competitiveness. An unattractive environment for productive entrepreneurship has created barriers to the entry of SMEs, and at the same time large informal economies. Several countries have become labour-export economies, with significant outflows of skilled labour. Economic development follows a low-skill growth path. The current global economic crisis is having a further deleterious effect as export revenues, foreign direct investment, and labour remittances all diminish. Furthermore, as transition has proceeded, disparities between capital cities and rural areas have increased, while weak administrative capacities have hindered the implementation of effective local development policies to counteract these effects. Endogenous local development cannot provide an alternative to greater engagement with the global economy. The conclusion is that the countries of the region have been left out of the most beneficial elements of the globalisation process, while simultaneously suffering from its main defects. Without a faster process of accession to the EU, local disparities are likely to widen, and the region may remain within the European super-periphery for the foreseeable future.

  19. Spike rate and spike timing contributions to coding taste quality information in rat periphery

    Directory of Open Access Journals (Sweden)

    Vernon eLawhern

    2011-05-01

    Full Text Available There is emerging evidence that individual sensory neurons in the rodent brain rely on temporal features of the discharge pattern to code differences in taste quality information. In contrast, in-vestigations of individual sensory neurons in the periphery have focused on analysis of spike rate and mostly disregarded spike timing as a taste quality coding mechanism. The purpose of this work was to determine the contribution of spike timing to taste quality coding by rat geniculate ganglion neurons using computational methods that have been applied successfully in other sys-tems. We recorded the discharge patterns of narrowly-tuned and broadly-tuned neurons in the rat geniculate ganglion to representatives of the five basic taste qualities. We used mutual in-formation to determine significant responses and the van Rossum metric to characterize their temporal features. While our findings show that spike timing contributes a significant part of the message, spike rate contributes the largest portion of the message relayed by afferent neurons from rat fungiform taste buds to the brain. Thus, spike rate and spike timing together are more effective than spike rate alone in coding stimulus quality information to a single basic taste in the periphery for both narrowly-tuned specialist and broadly-tuned generalist neurons.

  20. Elites and peripheries: educational innovation and cultural transferences in the Iberian Peninsula during Twentieth Century

    Directory of Open Access Journals (Sweden)

    Karmele Artetxe Sánchez

    2018-06-01

    Full Text Available What is the relationship between the configuration of educational institutions in theoretical and historical perspective and the phenomenon of the formation of elites? In this paper we consider that the answer to this question demands expanding our vision in the study of the elites. A vision that has to link studies on education with social processes and actors. This emphasis entails a more dynamic analysis where society presents itself without a theoretical corset, without reductionisms, composed of connected realities such as «the cultural», «the material» or «the social». The present monograph that we present in this editorial must be situated in this line of research insofar as it addresses the double dimension of fragmentation between center and periphery, proposing to address both the historical relations within the Iberian Peninsula and its historical relations towards Europe.

  1. Interpretation of the molecular fluxes measured at the periphery of a magnetically confined plasma

    International Nuclear Information System (INIS)

    Liu-Hinz, C.; Terreault, B.; Martin, F.

    1995-01-01

    A new instrument (''Variable Geometry Sniffer Probe'' or VGSP), allowing one to sample and mass analyse atoms, ions or molecules moving in different directions and at different locations at the periphery of a plasma, has been built and used in plasma edge studies in the TdeV tokamak. Three different regimes of particle sampling have been identified. First, the VGSP can measure the fluxes of hydrogen and impurity molecules issuing from the walls. Second, it has the capability of detecting low energy charge-exchange and Franck-Condon neutrals. Finally, there is a parallel ion flux sampling regime, for which it is shown that both the connection lengths to the divertor plates and the ExB plasma flows induced by edge electric fields play major roles. ((orig.))

  2. Foreign trade elasticities in centre-periphery models of growth and development

    Directory of Open Access Journals (Sweden)

    Anthony Philip Thirlwall

    1983-09-01

    Full Text Available The Author looks at the difference in growth rates among countries and argues that they can be traced to the strength of the balance of payments position, determined largely by the propensity to export relative to the propensity to import. Relative growth performance, thus, can be understood by looking to income elasticities of demand for exports and imports. This insight into the process of income determination in open economies, found in Harrod as well as in the literature on economic development, is developed through so-called centre-periphery models of growth and development. However, their essential conclusions were already contained in the early classic papers. The author concentrates on three of them (prebisch, seers, kaldor to argue that a country’s growth rate relative to another’s can be approximated by the ratio of its income elasticity of demand for exports to its income elasticity of demand for imports.

  3. Visualizing the molecular sociology at the HeLa cell nuclear periphery.

    Science.gov (United States)

    Mahamid, Julia; Pfeffer, Stefan; Schaffer, Miroslava; Villa, Elizabeth; Danev, Radostin; Cuellar, Luis Kuhn; Förster, Friedrich; Hyman, Anthony A; Plitzko, Jürgen M; Baumeister, Wolfgang

    2016-02-26

    The molecular organization of eukaryotic nuclear volumes remains largely unexplored. Here we combined recent developments in cryo-electron tomography (cryo-ET) to produce three-dimensional snapshots of the HeLa cell nuclear periphery. Subtomogram averaging and classification of ribosomes revealed the native structure and organization of the cytoplasmic translation machinery. Analysis of a large dynamic structure-the nuclear pore complex-revealed variations detectable at the level of individual complexes. Cryo-ET was used to visualize previously elusive structures, such as nucleosome chains and the filaments of the nuclear lamina, in situ. Elucidation of the lamina structure provides insight into its contribution to metazoan nuclear stiffness. Copyright © 2016, American Association for the Advancement of Science.

  4. Article-level metrics and the periphery: an exploration of articles by Brazilian authors

    Energy Technology Data Exchange (ETDEWEB)

    Souza, I.V.P.; Gouveia, F.C.

    2016-07-01

    This work-in-progress paper describes an ongoing PhD study that aims to explore article-level metrics from a set of articles published by Brazilian researchers. It is argued that article-level metrics can offer a more nuanced and accurate picture of the influence of a particular work in comparison to journal-level metrics. However, if these new metrics rely on sources that exclude a large part of research from the periphery, they are at risk of simply preserving the present inequalities in the scholarly communication system. In order to understand how article-level metrics are or could be useful to the scientific community in the peripheries, we need to see what metrics are currently available, identify possible biases, and understand their meaning. We aim to contribute to this discussion with a case study focused on exploring a set of both traditional and alternative article-level metrics related to publications authored by Brazilian researchers. So far, few studies analyse article-level metrics for Brazilian publications, and most focus on Brazilian journals instead of researcher's affiliation. Our study will collect articles with DOIs registered by Brazilian researchers at the Lattes Platform, an information system maintained by the national Science, Technologies and Communications ministry. This exploration aims to address the following questions: (a) Which are the main article-level metrics available for journal articles authored by Brazilian researchers? What are the main sources of ALM data for Brazilian publications?; (b) Are there any disciplines, institutions, locations etc. that attract more mentions in the case of Brazilian articles? How do these metrics compare among themselves?; and (c) Do articlelevel metrics of publications by Brazilian researchers reflect patterns and trends observed in studies with researchers from other countries? (Author)

  5. The Axum-Adwa basalt-trachyte complex: a late magmatic activity at the periphery of the Afar plume

    Science.gov (United States)

    Natali, C.; Beccaluva, L.; Bianchini, G.; Siena, F.

    2013-08-01

    The Axum-Adwa igneous complex consists of a basalt-trachyte (syenite) suite emplaced at the northern periphery of the Ethiopian plateau, after the paroxysmal eruption of the Oligocene (ca 30 Ma) continental flood basalts (CFB), which is related to the Afar plume activity. 40Ar/39Ar and K-Ar ages, carried out for the first time on felsic and basaltic rocks, constrain the magmatic age of the greater part of the complex around Axum to 19-15 Ma, whereas trachytic lavas from volcanic centres NE of Adwa are dated ca 27 Ma. The felsic compositions straddle the critical SiO2-saturation boundary, ranging from normative quartz trachyte lavas east of Adwa to normative (and modal) nepheline syenite subvolcanic domes (the obelisks stones of ancient axumites) around Axum. Petrogenetic modelling based on rock chemical data and phase equilibria calculations by PELE (Boudreau 1999) shows that low-pressure fractional crystallization processes, starting from mildly alkaline- and alkaline basalts comparable to those present in the complex, could generate SiO2-saturated trachytes and SiO2-undersaturated syenites, respectively, which correspond to residual liquid fractions of 17 and 10 %. The observed differentiation processes are consistent with the development of rifting events and formation of shallow magma chambers plausibly located between displaced (tilted) crustal blocks that favoured trapping of basaltic parental magmas and their fractionation to felsic differentiates. In syenitic domes, late- to post-magmatic processes are sometimes evidenced by secondary mineral associations (e.g. Bete Giorgis dome) which overprint the magmatic parageneses, and mainly induce additional nepheline and sodic pyroxene neo-crystallization. These metasomatic reactions were promoted by the circulation of Na-Cl-rich deuteric fluids (600-400 °C), as indicated by mineral and bulk rock chemical budgets as well as by δ18O analyses on mineral separates. The occurrence of this magmatism post-dating the

  6. Analysing the Demography and Migration Related Challenges within the Internal Periphery of South-Heves

    Directory of Open Access Journals (Sweden)

    Tunde Bogardi

    2015-04-01

    Full Text Available The purpose of my study is to perform an analysis with the application of regional statistical data, in order to understand the changes within the number of the population at South-Heves in the past period, and to the reveal its special characteristics compared to regional, national trends. The examined area is a classic internal periphery, a region “hit severely by social, economic and environmental crisis” (according to the draft proposal of Heves county’s regional development concept (2014-2020. Considering such regions, besides the examination of the intention to migrate, it is also important to see who will remain in the region. Experiences show that in case of regions with a more disadvantageous situation than average, generally classes of lower social statuses will become dominant, while as it is described by Győri-Nagy (2003, “the escape of competent classes of the population” can be observed. It results in a contra-selected local society which is unable to retain the young and ambitious. The future of the affected regions, settlements is largely determined by the perspectives perceived by young people who live there, and who shall start their families and careers there in the near future. I have conducted an empirical research amongst high-school students living and studying at South-Heves, focusing on issues such as whether the high-school age-group of this classic periphery is considering migration; if so, then what are the reasons, destinations, and as an important question from the aspect of the national strategy as well, how could these young people who are longing to go elsewhere manage their lives here, and how could we make them stay in their homeland (in a narrow sense. By investigating the intention to migrate, we also receive indirect answers for questions such as how could significant regional differences be reduced, and how could we close the gap in case of the most disadvantageous regions.

  7. Ultra-Widefield Steering-Based SD-OCT Imaging of the Retinal Periphery

    Science.gov (United States)

    Choudhry, Netan; Golding, John; Manry, Matthew W.; Rao, Rajesh C.

    2016-01-01

    Objective To describe the spectral-domain optical coherence tomography (SD-OCT) features of peripheral retinal findings using an ultra-widefield (UWF) steering technique to image the retinal periphery. Design Observational study. Participants 68 patients (68 eyes) with 19 peripheral retinal features. Main Outcome Measures SD-OCT-based structural features. Methods Nineteen peripheral retinal features including: vortex vein, congenital hypertrophy of the retinal pigment epithelium (CHRPE), pars plana, ora serrata pearl, typical cystoid degeneration (TCD), cystic retinal tuft, meridional fold, lattice and cobblestone degeneration, retinal hole, retinal tear, rhegmatogenous retinal detachment (RRD), typical degenerative senile retinoschisis, peripheral laser coagulation scars, ora tooth, cryopexy scars (retinal tear and treated retinoblastoma scar), bone spicules, white without pressure, and peripheral drusen were identified by peripheral clinical examination. Near infrared (NIR) scanning laser ophthalmoscopy (SLO) images and SD-OCT of these entities were registered to UWF color photographs. Results SD-OCT resolved structural features of all peripheral findings. Dilated hyporeflective tubular structures within the choroid were observed in the vortex vein. Loss of retinal lamination, neural retinal attenuation, RPE loss or hypertrophy were seen in several entities including CHRPE, ora serrata pearl, TCD, cystic retinal tuft, meridional fold, lattice and cobblestone degenerations. Hyporeflective intraretinal spaces, indicating cystoid or schitic fluid, were seen in ora serrata pearl, ora tooth, TCD, cystic retinal tuft, meridional fold, retinal hole, and typical degenerative senile retinoschisis. The vitreoretinal interface, which often consisted of lamellae-like structures of the condensed cortical vitreous near or adherent to the neural retina, appeared clearly in most peripheral findings, confirming its association with many low-risk and vision-threatening pathologies

  8. Chemical dampening of Ly6C(hi) monocytes in the periphery produces anti-depressant effects in mice.

    Science.gov (United States)

    Zheng, Xiao; Ma, Sijing; Kang, An; Wu, Mengqiu; Wang, Lin; Wang, Qiong; Wang, Guangji; Hao, Haiping

    2016-01-19

    The involvement of systemic immunity in depression pathogenesis promises a periphery-targeting paradigm in novel anti-depressant discovery. However, relatively little is known about druggable targets in the periphery for mental and behavioral control. Here we report that targeting Ly6C(hi) monocytes in blood can serve as a strategy for anti-depressant purpose. A natural compound, ginsenoside Rg1 (Rg1), was firstly validated as a periphery-restricted chemical probe. Rg1 selectively suppressed Ly6C(hi) monocytes recruitment to the inflamed mice brain. The proinflammatory potential of Ly6C(hi) monocytes to activate astrocytes was abrogated by Rg1, which led to a blunted feedback release of CCL2 to recruit the peripheral monocytes. In vitro study demonstrated that Rg1 pretreatment on activated THP-1 monocytes retarded their ability to trigger CCL2 secretion from co-cultured U251 MG astrocytes. CCL2-triggered p38/MAPK and PI3K/Akt activation were involved in the action of Rg1. Importantly, in mice models, we found that dampening Ly6C(hi) monocytes at the periphery ameliorated depression-like behavior induced by neuroinflammation or chronic social defeat stress. Together, our work unravels that blood Ly6C(hi) monocytes may serve as the target to enable remote intervention on the depressed brain, and identifies Rg1 as a lead compound for designing drugs targeting peripheral CCL2 signals.

  9. News Quantum physics: German Physical Society spring meeting Journal access: American Physical Society's online journals will be available for free in all US high schools Award: High-school physics teacher receives American award for excellence Teacher training: Fobinet offers coordination of teacher-training activities Astronomy: Astronomy fans see stars at Astrofest Conference: Delegates enjoy the workshops and activities at CPD conference Forthcoming events

    Science.gov (United States)

    2011-05-01

    Quantum physics: German Physical Society spring meeting Journal access: American Physical Society's online journals will be available for free in all US high schools Award: High-school physics teacher receives American award for excellence Teacher training: Fobinet offers coordination of teacher-training activities Astronomy: Astronomy fans see stars at Astrofest Conference: Delegates enjoy the workshops and activities at CPD conference Forthcoming events

  10. On the Peripheries of Scholarly Infrastructure: A look at the Journals Using Open Journal Systems

    Energy Technology Data Exchange (ETDEWEB)

    Alperin, J.P.; Stranack, K.; Garnett, A.

    2016-07-01

    Although there have been calls for scholarly infrastructure to be inclusive, new layers of infrastructure are built without a clear understanding of the breadth of scholarly journals that lie on the peripheries of the existing infrastructure. In the hopes that future infrastructure can take a wider range of journals into account, this paper presents the results of an effort to track the number, location, and rate of publication of journals using Open Journal Systems, an open source manuscript management and publication system built by the Public Knowledge Project. The method employed, which involves a combination of scanning weblogs, scraping webpages, and harvesting metadata, has yielded an estimated 9,828 journals that have collectively published 2,565,300 articles since 1990. These journals are distributed across 136 countries on 6 continents, and, in 2015, around a fifth of the OJS journals were published in low or low-middle income countries, and over a third in upper-middle income countries, suggesting that the majority of OJS journals are on the on the “periphery” of today's global scholarly infrastructure. As infrastructure and services continue to be developed, this paper argues, it is necessary to look to such journal so that the infrastructure that is built can be developed in a way that is truly inclusive of the global nature of scholarship. (Author)

  11. Conservation′s Ambiguities: Rangers on the Periphery of the W Park, Burkina Faso

    Directory of Open Access Journals (Sweden)

    Julie Poppe

    2012-01-01

    Full Text Available This article demonstrates the central role of ambiguity in the (reproduction process of conservation practice. It argues that some current political economy as well as environmentality approaches to research conservation practice fail to capture the complexity of the lived experience of local conservationists. The article focuses on the multiple identities of rangers in interaction with other residents at the periphery of the W Park in Burkina Faso, as rangers are local conservationists who simultaneously submit to and produce conservation practices. Park rangers are village men who are recruited under the banner of community participation in conservation projects and state forestry. On a day-to-day basis, these rangers help the foresters with the management of the natural resources on the one hand, and guide tourists, especially in the hunting concessions, on the other. They occupy ambiguous positions at the crossroads of conservationist, state, political, economic, spiritual, social, and cultural practices, inherent to their conservation occupations at the lowest echelon, where residents have to transform conservation policies into practices. It is precisely this ambiguity that turns out to ensure the conservation implementation.

  12. The competitiveness of Eurozone periphery countries’ economies and their debt problems

    Directory of Open Access Journals (Sweden)

    Dementiev N. P.

    2016-03-01

    Full Text Available The article describes that after the periphery PIGS countries (Portugal, Ireland, Greece and Spain joined the Eurozone, several factors previously improving PIGS' export competitiveness (undervalued national currency, protective customs duty, low compensation of employees no longer work. It is revealed that in the pre-crisis years the rapid GDP growth in PIGS took place considerably by means of foreign loans. Moreover, external debt bubbles grew: high rates of economic growth facilitated the inflow of new foreign money used for both reinvestment and current external debt service. Besides, the share of «tradable» goods (that can be moved between countries and internationally traded decreased in the GDP structures of PIGS. During the crisis, the PIGS' economic situation got worse (growth of external and public debts, decline in the GDP and in the investments, high unemployment. Conclusion: the Eurozone should either strengthen the integration (to increase the unification of laws in the economic and social spheres, to tighten control by the Eurozone central authorities, or get rid of the troubled countries. Otherwise, the current crisis, repeatedly flaring and fading, will persist for a long time.

  13. THE COMPETITIVENESS OF EUROZONE PERIPHERY COUNTRIES’ ECONOMIES AND THEIR DEBT PROBLEMS

    Directory of Open Access Journals (Sweden)

    Dementiev N. P.

    2016-03-01

    Full Text Available The article describes that after the periphery PIGS countries (Portugal, Ireland, Greece and Spain joined the Eurozone, several factors previously improving PIGS' export competitiveness (undervalued national currency, protective customs duty, low compensation of employees no longer work. It is revealed that in the pre-crisis years the rapid GDP growth in PIGS took place considerably by means of foreign loans. Moreover, external debt bubbles grew: high rates of economic growth facilitated the inflow of new foreign money used for both reinvestment and current external debt service. Besides, the share of «tradable» goods (that can be moved between countries and internationally traded decreased in the GDP structures of PIGS. During the crisis, the PIGS' economic situation got worse (growth of external and public debts, decline in the GDP and in the investments, high unemployment. Conclusion: the Eurozone should either strengthen the integration (to increase the unification of laws in the economic and social spheres, to tighten control by the Eurozone central authorities, or get rid of the troubled countries. Otherwise, the current crisis, repeatedly flaring and fading, will persist for a long time.

  14. Attention effects at auditory periphery derived from human scalp potentials: displacement measure of potentials.

    Science.gov (United States)

    Ikeda, Kazunari; Hayashi, Akiko; Sekiguchi, Takahiro; Era, Shukichi

    2006-10-01

    It is known in humans that electrophysiological measures such as the auditory brainstem response (ABR) are difficult to identify the attention effect at the auditory periphery, whereas the centrifugal effect has been detected by measuring otoacoustic emissions. This research developed a measure responsive to the shift of human scalp potentials within a brief post-stimulus period (13 ms), that is, displacement percentage, and applied it to an experiment to retrieve the peripheral attention effect. In the present experimental paradigm, tone pips were exposed to the left ear whereas the other ear was masked by white noise. Twelve participants each conducted two conditions of either ignoring or attending to the tone pips. Relative to averaged scalp potentials in the ignoring condition, the shift of the potentials was found within early component range during the attentive condition, and displacement percentage then revealed a significant magnitude difference between the two conditions. These results suggest that, using a measure representing the potential shift itself, the peripheral effect of attention can be detected from human scalp potentials.

  15. Numerical study of whisker field lines in the periphery of the Large Helical Device

    International Nuclear Information System (INIS)

    Akao, Hideki

    1990-01-01

    The behavior of periphery magnetic field lines in the standard Large-Helical Device (l=2 heliotron/torsatron type) configuration is studied numerically. Three different types of behavior are found, corresponding to three different regions: the stochastic region near the outermost magnetic surface, the whisker region, and the inter-whisker region outside the stochastic region. The behavior of whisker and inter-whisker field lines is specifically analyzed. It is found that whisker field lines exhibit both regular and irregular types of behavior, whereas inter-whisker field lines exhibit only regular behavior. The connection lengths for the whisker field lines are usually as long as several tens of toroidal pitches, whereas those for the inter-whisker field lines are usually less than ten toroidal pitch lengths. Whisker field lines are characterized by three fundamental processes; stretching, folding, and nesting associated with the motion of a residual X-point of the separatrix. Simple modeling is performed to reproduce these three fundamental processes. (author)

  16. Strategies to regulate transcription factor-mediated gene positioning and interchromosomal clustering at the nuclear periphery.

    Science.gov (United States)

    Randise-Hinchliff, Carlo; Coukos, Robert; Sood, Varun; Sumner, Michael Chas; Zdraljevic, Stefan; Meldi Sholl, Lauren; Garvey Brickner, Donna; Ahmed, Sara; Watchmaker, Lauren; Brickner, Jason H

    2016-03-14

    In budding yeast, targeting of active genes to the nuclear pore complex (NPC) and interchromosomal clustering is mediated by transcription factor (TF) binding sites in the gene promoters. For example, the binding sites for the TFs Put3, Ste12, and Gcn4 are necessary and sufficient to promote positioning at the nuclear periphery and interchromosomal clustering. However, in all three cases, gene positioning and interchromosomal clustering are regulated. Under uninducing conditions, local recruitment of the Rpd3(L) histone deacetylase by transcriptional repressors blocks Put3 DNA binding. This is a general function of yeast repressors: 16 of 21 repressors blocked Put3-mediated subnuclear positioning; 11 of these required Rpd3. In contrast, Ste12-mediated gene positioning is regulated independently of DNA binding by mitogen-activated protein kinase phosphorylation of the Dig2 inhibitor, and Gcn4-dependent targeting is up-regulated by increasing Gcn4 protein levels. These different regulatory strategies provide either qualitative switch-like control or quantitative control of gene positioning over different time scales. © 2016 Randise-Hinchliff et al.

  17. Immune System Activation and Depression: Roles of Serotonin in the Central Nervous System and Periphery.

    Science.gov (United States)

    Robson, Matthew J; Quinlan, Meagan A; Blakely, Randy D

    2017-05-17

    Serotonin (5-hydroxytryptamine, 5-HT) has long been recognized as a key contributor to the regulation of mood and anxiety and is strongly associated with the etiology of major depressive disorder (MDD). Although more known for its roles within the central nervous system (CNS), 5-HT is recognized to modulate several key aspects of immune system function that may contribute to the development of MDD. Copious amounts of research have outlined a connection between alterations in immune system function, inflammation status, and MDD. Supporting this connection, peripheral immune activation results in changes in the function and/or expression of many components of 5-HT signaling that are associated with depressive-like phenotypes. How 5-HT is utilized by the immune system to effect CNS function and ultimately behaviors related to depression is still not well understood. This Review summarizes the evidence that immune system alterations related to depression affect CNS 5-HT signaling that can alter MDD-relevant behaviors and that 5-HT regulates immune system signaling within the CNS and periphery. We suggest that targeting the interrelationships between immune and 5-HT signaling may provide more effective treatments for subsets of those suffering from inflammation-associated MDD.

  18. A Periphery Becomes a Center? Shopping Malls as Symbols of Modernity in Iraqi Kurdistan

    Directory of Open Access Journals (Sweden)

    Schluwa Sama

    2015-11-01

    Full Text Available Being labelled and framed as a remote periphery of Iraq, the Kurdistan Region of Iraq is transforming since 2003 into a center attracting investments worth billions of dollars. Investigating this transformation, I scrutinize one of the visible outcomes of the investments, namely shop- ping malls, as examples and symbols of “modernity” and “progress.” The recently built shopping malls are thereby analyzed as the built materialization and symbols of neoliberal transformation and socio-economic change. Engaging with representatives of shopping malls as well as with the experiences of young female shopping-mall-goers, it will be illustrated how modernity and progress is framed within the Kurdish nationalist narrative and how this is taken up by young Kurdish female mall-goers. Thus, it will be contended that a historical narrative of past sufferings comes to legitimize the new liberal “freedoms” that are available through the full connection to and participation of Iraqi Kurdistan in the capitalist economic world system.

  19. Coordination Logic for Repulsive Resolution Maneuvers

    Science.gov (United States)

    Narkawicz, Anthony J.; Munoz, Cesar A.; Dutle, Aaron M.

    2016-01-01

    This paper presents an algorithm for determining the direction an aircraft should maneuver in the event of a potential conflict with another aircraft. The algorithm is implicitly coordinated, meaning that with perfectly reliable computations and information, it will in- dependently provide directional information that is guaranteed to be coordinated without any additional information exchange or direct communication. The logic is inspired by the logic of TCAS II, the airborne system designed to reduce the risk of mid-air collisions between aircraft. TCAS II provides pilots with only vertical resolution advice, while the proposed algorithm, using a similar logic, provides implicitly coordinated vertical and horizontal directional advice.

  20. A Novel Temperature Compensation Method for a MEMS Gyroscope Oriented on a Periphery Circuit

    Directory of Open Access Journals (Sweden)

    Huiliang Cao

    2013-09-01

    Full Text Available This paper investigates temperature compensation methods used for the scale factor and bias of the MEMS gyroscope within the temperature range from − 40°C to 60°C. The structure and periphery monitor circuit are introduced. Then the determinant elements of the MEMS gyroscope's scale factor are analysed and the results indicate that scale factor is directly proportional to drive amplitude and sense loop gain and is inversely proportional to the frequency gap between two modes. After that, the compensation methods are proposed, the thermal resistor's positive temperature coefficient (tempco is utilized to calibrate the scale factor's tempco through regulating the drive mode amplitude and the sense loop gain, and each method is applied respectively and the results are contrasted. The test results of the two specimens express that the most effective compensation method could decrease the scale factor's tempco from 693ppm/°C (640ppm/°C to 250ppm/°C (257ppm/°C, improving it by 63.9% (59.8%. Finally, a method of declining bias's tempco is investigated and implemented after scale factor compensation. A summator with a thermal resistor is utilized at the output level and decreases the bias's tempco from 103.89°/h/°C (100.78°/h/°C to 9.70°/h/°C (12°/h/°C improving it by 90.7% (88%. Repeat tests are performed based on two specimens to prove the repeatability and reproducibility of the methods.

  1. Effects of Unaugmented Periphery and Vibrotactile Feedback on Proxemics with Virtual Humans in AR.

    Science.gov (United States)

    Lee, Myungho; Bruder, Gerd; Hollerer, Tobias; Welch, Greg

    2018-04-01

    In this paper, we investigate factors and issues related to human locomotion behavior and proxemics in the presence of a real or virtual human in augmented reality (AR). First, we discuss a unique issue with current-state optical see-through head-mounted displays, namely the mismatch between a small augmented visual field and a large unaugmented periphery, and its potential impact on locomotion behavior in close proximity of virtual content. We discuss a potential simple solution based on restricting the field of view to the central region, and we present the results of a controlled human-subject study. The study results show objective benefits for this approach in producing behaviors that more closely match those that occur when seeing a real human, but also some drawbacks in overall acceptance of the restricted field of view. Second, we discuss the limited multimodal feedback provided by virtual humans in AR, present a potential improvement based on vibrotactile feedback induced via the floor to compensate for the limited augmented visual field, and report results showing that benefits of such vibrations are less visible in objective locomotion behavior than in subjective estimates of co-presence. Third, we investigate and document significant differences in the effects that real and virtual humans have on locomotion behavior in AR with respect to clearance distances, walking speed, and head motions. We discuss potential explanations for these effects related to social expectations, and analyze effects of different types of behaviors including idle standing, jumping, and walking that such real or virtual humans may exhibit in the presence of an observer.

  2. The importance of an alternative for sustainability of agriculture around the periphery of the Amazon rainforest.

    Science.gov (United States)

    Moura, Emanoel G; Sena, Virley G L; Corrêa, Mariana S; Aguiar, Alana das C F

    2013-04-01

    The unsustainable use of the soil of the deforested area at the Amazonian border is one of the greatest threats to the rainforest, because it is the predominant cause of shifting cultivation in the region. The sustainable management of soils with low natural fertility is a major challenge for smallholder agriculture in the humid tropics. In the periphery of Brazilian Amazonia, agricultural practices that are recommended for the Brazilian savannah, such as saturating soils with soluble nutrients do not ensure the sustainability of agroecosystems. Improvements in the tilled topsoil cannot be maintained if deterioration of the porous soil structure is not prevented and nutrient losses in the root zone are not curtailed. The information gleaned from experiments affirms that in the management of humid tropical agrosystems, the processes resulting from the interaction between climatic factors and indicators of soil quality must be taken into consideration. It must be remembered that these interactions manifest themselves in ways that cannot be predicted from the paradigm established in the other region like the southeast of Brazil, which is based only on improving the chemical indicators of soil quality. The physical indicators play important role in the sustainable management of the agrosystems of the region and for these reasons must be considered. Therefore, alley cropping is a potential substitute for slash and burn agriculture in the humid tropics with both environmental and agronomic advantages, due to its ability to produce a large amount of residues on the soil surface and its effect on the increase of economic crop productivity in the long term. The article presents some promising patents on the importance of an alternative for sustainability of agriculture.

  3. Explicitly computing geodetic coordinates from Cartesian coordinates

    Science.gov (United States)

    Zeng, Huaien

    2013-04-01

    This paper presents a new form of quartic equation based on Lagrange's extremum law and a Groebner basis under the constraint that the geodetic height is the shortest distance between a given point and the reference ellipsoid. A very explicit and concise formulae of the quartic equation by Ferrari's line is found, which avoids the need of a good starting guess for iterative methods. A new explicit algorithm is then proposed to compute geodetic coordinates from Cartesian coordinates. The convergence region of the algorithm is investigated and the corresponding correct solution is given. Lastly, the algorithm is validated with numerical experiments.

  4. Event generators for address event representation transmitters

    Science.gov (United States)

    Serrano-Gotarredona, Rafael; Serrano-Gotarredona, Teresa; Linares Barranco, Bernabe

    2005-06-01

    Address Event Representation (AER) is an emergent neuromorphic interchip communication protocol that allows for real-time virtual massive connectivity between huge number neurons located on different chips. By exploiting high speed digital communication circuits (with nano-seconds timings), synaptic neural connections can be time multiplexed, while neural activity signals (with mili-seconds timings) are sampled at low frequencies. Also, neurons generate 'events' according to their activity levels. More active neurons generate more events per unit time, and access the interchip communication channel more frequently, while neurons with low activity consume less communication bandwidth. In a typical AER transmitter chip, there is an array of neurons that generate events. They send events to a peripheral circuitry (let's call it "AER Generator") that transforms those events to neurons coordinates (addresses) which are put sequentially on an interchip high speed digital bus. This bus includes a parallel multi-bit address word plus a Rqst (request) and Ack (acknowledge) handshaking signals for asynchronous data exchange. There have been two main approaches published in the literature for implementing such "AER Generator" circuits. They differ on the way of handling event collisions coming from the array of neurons. One approach is based on detecting and discarding collisions, while the other incorporates arbitration for sequencing colliding events . The first approach is supposed to be simpler and faster, while the second is able to handle much higher event traffic. In this article we will concentrate on the second arbiter-based approach. Boahen has been publishing several techniques for implementing and improving the arbiter based approach. Originally, he proposed an arbitration squeme by rows, followed by a column arbitration. In this scheme, while one neuron was selected by the arbiters to transmit his event out of the chip, the rest of neurons in the array were

  5. The Urban Enclave, a Spatio–Temporal Logic of the Urbanized Periphery: Effects on Residential Segregation and Urban Fragmentation

    Directory of Open Access Journals (Sweden)

    Guénola Capron

    2016-07-01

    Full Text Available The production of the metropolitan peripheries in Latin America has been characterized by the development of urban, residential and commercial enclaves. These enclaves encompass both large urban housing projects of social interest and subdivisions and gated communities for high–income populations. Both peripheries respond to very different social reasons but have a common spatial logic: the enclave, which deepens the isolation and social distance with its surroundings, generating segregation and fragmentation. We seek to rescue the social and spatial processes of ‘enclosing’ or ‘insularity’ in two cases: a gated community in the northeast — Zona Esmeralda— and a social housing urban complex in the east —San Buenaventura—, both bordering the metropolitan area of the Mexico Valley.

  6. Centre and/or periphery? On the cognitive and social construal of identity in a local community

    DEFF Research Database (Denmark)

    Hovmark, Henrik

    2010-01-01

    -cultural setting, mass media, and politics (the island as periphery). Interestingly, the latter discourse could also be connected to local practices in which the new role of the island was being enacted and entrenched by the informants in their local environment. The data show that cognitive models can be subject......Centre and/or periphery? On the cognitive and social construal of identity in a local community Danish Directional Adverbs (DDA) (for instance op ‘up', ned ‘down', ud ‘out', ind ‘in') are very frequently used deictically to profile a specific conceptualisation of and relation to places, persons...... communicative and social spheres or deictic centres within the wider language community: individual, local, and supra-local (Hovmark 2007). Local communities can develop and conventionalise specific conceptualisations ("world views"), thus supporting recent findings that (dia)lectal variation is important...

  7. IAEA coordinated research program on `harmonization and validation of fast reactor thermomechanical and thermohydraulic codes using experimental data`. 1. Thermohydraulic benchmark analysis on high-cycle thermal fatigue events occurred at French fast breeder reactor Phenix

    Energy Technology Data Exchange (ETDEWEB)

    Muramatsu, Toshiharu [Power Reactor and Nuclear Fuel Development Corp., Oarai, Ibaraki (Japan). Oarai Engineering Center

    1997-06-01

    A benchmark exercise on `Tee junction of Liquid Metal Fast Reactor (LMFR) secondary circuit` was proposed by France in the scope of the said Coordinated Research Program (CRP) via International Atomic Energy Agency (IAEA). The physical phenomenon chosen here deals with the mixture of two flows of different temperature. In a LMFR, several areas of the reactor are submitted to this problem. They are often difficult to design, because of the complexity of the phenomena involved. This is one of the major problems of the LMFRs. This problem has been encountered in the Phenix reactor on the secondary loop, where defects in a tee junction zone were detected during a campaign of inspections after an operation of 90,000 hours of the reactor. The present benchmark is based on an industrial problem and deal with thermal striping phenomena. Problems on pipes induced by thermal striping phenomena have been observed in some reactors and experimental facilities coolant circuits. This report presents numerical results on thermohydraulic characteristics of the benchmark problem, carried out using a direct numerical simulation code DINUS-3 and a boundary element code BEMSET. From the analysis with both the codes, it was confirmed that the hot sodium from the small pipe rise into the cold sodium of the main pipe with thermally instabilities. Furthermore, it was indicated that the coolant mixing region including the instabilities agrees approximately with the result by eye inspections. (author)

  8. Analysis of core-periphery organization in protein contact networks reveals groups of structurally and functionally critical residues.

    Science.gov (United States)

    Isaac, Arnold Emerson; Sinha, Sitabhra

    2015-10-01

    The representation of proteins as networks of interacting amino acids, referred to as protein contact networks (PCN), and their subsequent analyses using graph theoretic tools, can provide novel insights into the key functional roles of specific groups of residues. We have characterized the networks corresponding to the native states of 66 proteins (belonging to different families) in terms of their core-periphery organization. The resulting hierarchical classification of the amino acid constituents of a protein arranges the residues into successive layers - having higher core order - with increasing connection density, ranging from a sparsely linked periphery to a densely intra-connected core (distinct from the earlier concept of protein core defined in terms of the three-dimensional geometry of the native state, which has least solvent accessibility). Our results show that residues in the inner cores are more conserved than those at the periphery. Underlining the functional importance of the network core, we see that the receptor sites for known ligand molecules of most proteins occur in the innermost core. Furthermore, the association of residues with structural pockets and cavities in binding or active sites increases with the core order. From mutation sensitivity analysis, we show that the probability of deleterious or intolerant mutations also increases with the core order. We also show that stabilization centre residues are in the innermost cores, suggesting that the network core is critically important in maintaining the structural stability of the protein. A publicly available Web resource for performing core-periphery analysis of any protein whose native state is known has been made available by us at http://www.imsc.res.in/ ~sitabhra/proteinKcore/index.html.

  9. Revisited microanatomy of the corneal endothelial periphery: new evidence for continuous centripetal migration of endothelial cells in humans.

    Science.gov (United States)

    He, Zhiguo; Campolmi, Nelly; Gain, Philippe; Ha Thi, Binh Minh; Dumollard, Jean-Marc; Duband, Sébastien; Peoc'h, Michel; Piselli, Simone; Garraud, Olivier; Thuret, Gilles

    2012-11-01

    The control of corneal transparency depends on the integrity of its endothelial monolayer, which is considered nonregenerative in adult humans. In pathological situations, endothelial cell (EC) loss, not offset by mitosis, can lead to irreversible corneal edema and blindness. However, the hypothesis of a slow, clinically insufficient regeneration starting from the corneal periphery remains debatable. The authors have re-evaluated the microanatomy of the endothelium in order to identify structures likely to support this homeostasis model. Whole endothelia of 88 human corneas (not stored, and stored in organ culture) with mean donor age of 80 ± 12 years were analyzed using an original flat-mounting technique. In 61% of corneas, cells located at the extreme periphery (last 200 μm of the endothelium) were organized in small clusters with two to three cell layers around Hassall-Henle bodies. In 68% of corneas, peripheral ECs formed centripetal rows 830 ± 295 μm long, with Descemet membrane furrows visible by scanning electron microscopy. EC density was significantly higher in zones with cell rows. When immunostained, ECs in the extreme periphery exhibited lesser differentiation (ZO-1, Actin, Na/K ATPase, CoxIV) than ECs in the center of the cornea but preferentially expressed stem cell markers (Nestin, Telomerase, and occasionally breast cancer resistance protein) and, in rare cases, the proliferation marker Ki67. Stored corneas had fewer cell clusters but more Ki67-positive ECs. We identified a novel anatomic organization in the periphery of the human corneal endothelium, suggesting a continuous slow centripetal migration, throughout life, of ECs from specific niches. Copyright © 2012 AlphaMed Press.

  10. Consequences of ponderomotive effects at the plasma periphery on the electrical behaviour of a multijunction grill lower hybrid launcher

    International Nuclear Information System (INIS)

    Hurtak, O.; Klima, R.; Petrzilka, V.A.

    1991-01-01

    A radiofrequency power-plasma coupling code which takes into account ponderomotive effects at the plasma periphery is developed for a multijunction grill. At a frequency of 4.6 GHz, if the RF power density increases, the power reflection coefficient remains fairly low, while the distribution of power among subsidiary waveguides deteriorates. At lower frequencies, the danger of overloading individual waveguides is expected to be still greater. (author). Letter-to-the-editor. 14 refs, 4 figs

  11. The curvature coordinate system

    DEFF Research Database (Denmark)

    Almegaard, Henrik

    2007-01-01

    The paper describes a concept for a curvature coordinate system on regular curved surfaces from which faceted surfaces with plane quadrangular facets can be designed. The lines of curvature are used as parametric lines for the curvature coordinate system on the surface. A new conjugate set of lin...

  12. Coordinate measuring machines

    DEFF Research Database (Denmark)

    De Chiffre, Leonardo

    This document is used in connection with three exercises of 2 hours duration as a part of the course GEOMETRICAL METROLOGY AND MACHINE TESTING. The exercises concern three aspects of coordinate measuring: 1) Measuring and verification of tolerances on coordinate measuring machines, 2) Traceabilit...... and uncertainty during coordinate measurements, 3) Digitalisation and Reverse Engineering. This document contains a short description of each step in the exercise and schemes with room for taking notes of the results.......This document is used in connection with three exercises of 2 hours duration as a part of the course GEOMETRICAL METROLOGY AND MACHINE TESTING. The exercises concern three aspects of coordinate measuring: 1) Measuring and verification of tolerances on coordinate measuring machines, 2) Traceability...

  13. Regular coordinate systems for Schwarzschild and other spherical spacetimes

    OpenAIRE

    Martel, Karl; Poisson, Eric

    2000-01-01

    The continuation of the Schwarzschild metric across the event horizon is almost always (in textbooks) carried out using the Kruskal-Szekeres coordinates, in terms of which the areal radius r is defined only implicitly. We argue that from a pedagogical point of view, using these coordinates comes with several drawbacks, and we advocate the use of simpler, but equally effective, coordinate systems. One such system, introduced by Painleve and Gullstrand in the 1920's, is especially simple and pe...

  14. Des périphéries « utiles » Usefull Peripheries

    Directory of Open Access Journals (Sweden)

    Jacques Ivanoff

    2012-10-01

    social groups as much as they are ethnic ones, each of them re-negotiating its place within the nation-state, recalling notions of choice, nomadic ideology and studies on the relationship between nomadic and settled peoples. The anthropology of borders is thus a field of research that must utilize classic anthropological tools while including the ethnic issues of these peripheries that no longer exist. Borders have always been a space where negotiations take place. They are organically linked to various centres and the ethnicities that live there use these new social, economic and political opportunities of “globalization” to build, assert or transcend their ethnicity, which must go hand-in-hand with the new world market. The disappearance of ethnicities is not on the agenda. On the contrary, it reveals the resilience of these peoples, which enables the researcher to observe a revival in the latent dynamics that belong to them. Their ways of appropriating resources, territories and crossing points are means of negotiations for these populations who, despite entering the general movement of today’s new international mobility, reveal no less than their “cultural heart”, their ethnic background that they must preserve.

  15. Ice-dammed lakes reconstruction in the southeastern Scandinavian ice sheet periphery

    Science.gov (United States)

    Anisimov, Nikolai

    2017-04-01

    The study of glacier erosion processes, paleolake dynamics and topographical changes, together give us insight into both localized and broader landscape evolution patterns while also assisting human exploration. After carrying number of paleographic discoveries of North-West of Russia, we've gathered the data requiring generalizing, systemizing, visualizing. Objective: reconstruction of proglacial lakes based on lithostratigraphic and geomorphic analysis using GIS technology. GIS modeling of ice-dammed lakes was done via the ArcGIS Desktop 10 software package. The GIS was used as a means to categorize published, time mapped data and thereby fuse and unify the changes into a single, integrated prototype. Publications on limnologo-glaciological and geomorphological reconstructions of paleotopography and paleolakes north of the Russian plain, along with additional copyrighted and grant-funded GIS studies, together served as resources to authenticate the paleolake contour modeling. A quaternary sediments map and an updated topography map that was designed via semiautomatic vectorization of a topographical map, served as foundations for the electronic shape modeling paleoreconstructions. Based upon preliminary results from publication summaries, and initial data collected when analyzing the maps (quaternary sediments, geomorphological, topographical), the contours and maximum glacial lake rise levels in the southeastern Scandinavian ice sheet periphery, including the levels and contours of their coastline, have been duly identified. Boundary reconstruction of Late Pleistocene lake boundaries have been completed for five sections of the Scandinavian ice sheet: the Molovo-Sheksninskoy, the Belozersko-Kubensky, the Vozhe-Lachsko-Kubensky, the Vazhskoy, and the Severodvinskoy. The territories studied revealed 13 major paleobasins covering an area of more than 1,000 km2, which based upon their position most closely resemble periglacial, intraglacial and postglacial lakes. Of

  16. From Periphery to Core (and Back? Political, Journalistic, and Academic Perceptions of Celtic Tiger- and post-Celtic Tiger-Ireland

    Directory of Open Access Journals (Sweden)

    Susan Nitzsche

    2014-01-01

    Full Text Available Since the Celtic Tiger, the concept of periphery has been an integral part of the debates on Ireland’s role in the world economy, on its position in the European Union, on its relationship with Great Britain and on internal regional disparities. Whereas Ireland has universally been perceived as being at the core of the European integration project, there is no consensus whether Celtic Tiger-Ireland eventually managed to leave the economic periphery or semi-periphery as defined in the World-Systems Analysis. Additionally, the Celtic Tiger did not manage to reduce regional disparity within Ireland – a fact that resulted in an increased focus on the internal periphery and core. The current recession negatively influences the perceptions of Ireland’s economic development and of its role in the European Union. 

  17. Zgaga, P., Teichler, U., & Brennan, J. (Eds.) (2012). The globalisation challenge for European higher education / Convergence and Diversity, Centres and Peripheries. Frankfurt/M.: Peter Lang. [Book review

    OpenAIRE

    Strajn, Darko

    2013-01-01

    Book review of: Zgaga, P., Teichler, U., & Brennan, J. (Eds.) (2012). The globalisation challenge for European higher education / Convergence and Diversity, Centres and Peripheries. Frankfurt/M.: Peter Lang. 389 pp., ISBN 978-3-631- 6398-5.

  18. Regional transit coordination guidebook.

    Science.gov (United States)

    2009-01-01

    Constant growth in rural areas and extensive suburban development have contributed to increasingly more people needing seamless and adequate public transportation into and from nearby cities. Coordinating existing services or determining the need for...

  19. Supercritical Airfoil Coordinates

    Data.gov (United States)

    National Aeronautics and Space Administration — Rectangular Supercritical Wing (Ricketts) - design and measured locations are provided in an Excel file RSW_airfoil_coordinates_ricketts.xls . One sheet is with Non...

  20. Developmental coordination disorder

    Science.gov (United States)

    Developmental coordination disorder can lead to: Learning problems Low self-esteem resulting from poor ability at sports and teasing by other children Repeated injuries Weight gain as a result of not wanting to participate ...

  1. Environmental Compliance Issue Coordination

    Science.gov (United States)

    An order to establish the Department of Energy (DOE) requirements for coordination of significant environmental compliance issues to ensure timely development and consistent application of Departmental environmental policy and guidance

  2. Data Management Coordinators (DMC)

    Science.gov (United States)

    The Regional Data Management Coordinators (DMCs) were identified to serve as the primary contact for each region for all Water Quality Framework activities. They will facilitate and communicate information to the necessary individuals at the region and tra

  3. Communicating Processes with Data for Supervisory Coordination

    Directory of Open Access Journals (Sweden)

    Jasen Markovski

    2012-08-01

    Full Text Available We employ supervisory controllers to safely coordinate high-level discrete(-event behavior of distributed components of complex systems. Supervisory controllers observe discrete-event system behavior, make a decision on allowed activities, and communicate the control signals to the involved parties. Models of the supervisory controllers can be automatically synthesized based on formal models of the system components and a formalization of the safe coordination (control requirements. Based on the obtained models, code generation can be used to implement the supervisory controllers in software, on a PLC, or an embedded (microprocessor. In this article, we develop a process theory with data that supports a model-based systems engineering framework for supervisory coordination. We employ communication to distinguish between the different flows of information, i.e., observation and supervision, whereas we employ data to specify the coordination requirements more compactly, and to increase the expressivity of the framework. To illustrate the framework, we remodel an industrial case study involving coordination of maintenance procedures of a printing process of a high-tech Oce printer.

  4. Coordinating Work with Groupware

    DEFF Research Database (Denmark)

    Pors, Jens Kaaber; Simonsen, Jesper

    2003-01-01

    One important goal of employing groupware is to make possible complex collaboration between geographically distributed groups. This requires a dual transformation of both technology and work practice. The challenge is to re­duce the complexity of the coordination work by successfully inte....... Using the CSCW frame­work of coordination mechanisms, we have elicited six general factors influencing the integration of the groupware application in two situations....

  5. Luminescent lanthanide coordination polymers

    Energy Technology Data Exchange (ETDEWEB)

    Ma, L.; Evans, O.R.; Foxman, B.M.; Lin, W.

    1999-12-13

    One-dimensional lanthanide coordination polymers with the formula Ln(isonicotinate){sub 3}(H{sub 2}O){sub 2} (Ln = Ce, Pr, Nd, Sm, Eu, Tb; 1a-f) were synthesized by treating nitrate or perchlorate salts of Ln(III) with 4-pyridinecarboxaldehyde under hydro(solvo)thermal conditions. Single-crystal and powder X-ray diffraction studies indicate that these lanthanide coordination polymers adopt two different structures. While Ce(III), Pr(III), and Nd(III) complexes adopt a chain structure with alternating Ln-(carboxylate){sub 2}-Ln and Ln-(carboxylate){sub 4}-Ln linkages, Sm(III), Eu(III), and Tb(III) complexes have a doubly carboxylate-bridged infinite-chain structure with one chelating carboxylate group on each metal center. In both structures, the lanthanide centers also bind to two water molecules to yield an eight-coordinate, square antiprismatic geometry. The pyridine nitrogen atoms of the isonicotinate groups do not coordinate to the metal centers in these lanthanide(III) complexes; instead, they direct the formation of Ln(III) coordination polymers via hydrogen bonding with coordinated water molecules. Photoluminescence measurements show that Tb(isonicotinate){sub 3}(H{sub 2}O){sub 2} is highly emissive at room temperature with a quantum yield of {approximately}90%. These results indicate that highly luminescent lanthanide coordination polymers can be assembled using a combination of coordination and hydrogen bonds. Crystal data for 1a: monoclinic space group P2{sub 1}/c, a = 9.712(2) {angstrom}, b = 19.833(4) {angstrom}, c = 11.616(2) {angstrom}, {beta} = 111.89(3){degree}, Z = 4. Crystal data for 1f: monoclinic space group C2/c, a = 20.253(4) {angstrom}, b = 11.584(2) {angstrom}, c = 9.839(2) {angstrom}, {beta} = 115.64(3){degree}, Z = 8.

  6. Coordinate-invariant regularization

    International Nuclear Information System (INIS)

    Halpern, M.B.

    1987-01-01

    A general phase-space framework for coordinate-invariant regularization is given. The development is geometric, with all regularization contained in regularized DeWitt Superstructures on field deformations. Parallel development of invariant coordinate-space regularization is obtained by regularized functional integration of the momenta. As representative examples of the general formulation, the regularized general non-linear sigma model and regularized quantum gravity are discussed. copyright 1987 Academic Press, Inc

  7. Magnetic Coordinate Systems

    Science.gov (United States)

    Laundal, K. M.; Richmond, A. D.

    2017-03-01

    Geospace phenomena such as the aurora, plasma motion, ionospheric currents and associated magnetic field disturbances are highly organized by Earth's main magnetic field. This is due to the fact that the charged particles that comprise space plasma can move almost freely along magnetic field lines, but not across them. For this reason it is sensible to present such phenomena relative to Earth's magnetic field. A large variety of magnetic coordinate systems exist, designed for different purposes and regions, ranging from the magnetopause to the ionosphere. In this paper we review the most common magnetic coordinate systems and describe how they are defined, where they are used, and how to convert between them. The definitions are presented based on the spherical harmonic expansion coefficients of the International Geomagnetic Reference Field (IGRF) and, in some of the coordinate systems, the position of the Sun which we show how to calculate from the time and date. The most detailed coordinate systems take the full IGRF into account and define magnetic latitude and longitude such that they are constant along field lines. These coordinate systems, which are useful at ionospheric altitudes, are non-orthogonal. We show how to handle vectors and vector calculus in such coordinates, and discuss how systematic errors may appear if this is not done correctly.

  8. Event Investigation

    International Nuclear Information System (INIS)

    Korosec, D.

    2000-01-01

    The events in the nuclear industry are investigated from the license point of view and from the regulatory side too. It is well known the importance of the event investigation. One of the main goals of such investigation is to prevent the circumstances leading to the event and the consequences of the event. The protection of the nuclear workers against nuclear hazard, and the protection of general public against dangerous effects of an event could be achieved by systematic approach to the event investigation. Both, the nuclear safety regulatory body and the licensee shall ensure that operational significant events are investigated in a systematic and technically sound manner to gather information pertaining to the probable causes of the event. One of the results should be appropriate feedback regarding the lessons of the experience to the regulatory body, nuclear industry and general public. In the present paper a general description of systematic approach to the event investigation is presented. The systematic approach to the event investigation works best where cooperation is present among the different divisions of the nuclear facility or regulatory body. By involving management and supervisors the safety office can usually improve their efforts in the whole process. The end result shall be a program which serves to prevent events and reduce the time and efforts solving the root cause which initiated each event. Selection of the proper method for the investigation and an adequate review of the findings and conclusions lead to the higher level of the overall nuclear safety. (author)

  9. Spatial divergence of living standards during the economic growth phase in the periphery: A case study of North Karelia

    Directory of Open Access Journals (Sweden)

    Olli Lehtonen

    2011-01-01

    Full Text Available The advisability of an urban-centred growth strategy in sparsely populated parts of Europe has not been much analysed at micro-levels such as that of the postcode area. This paper investigates how regional disparities in living standards continued to increase during the technology-driven growth phase of 1993−2003, as exemplified by the case of North Karelia in Finland. Urban sprawl conveyed the spread effects of the rise in incomes, and the upsurge of living standards was concentrated in the neighbourhood of the provincial centre, Joensuu. Living standards faced a process of double divergence: between the central district of Joensuu and its commuter belt, and between the provincial core area and its hinterland, the latter consisting of rural areas and small towns dependent largely on natural resources. The spatial outcome of this socio-economic reorganization is a three-zone core-periphery pattern. As the economy grew, geographical shifts in wealth were consequences of the growth and mobility of certain social groups and strata. A wave of high living standards towards the outskirts of the provincial centre was generated by an expansion in commuting. The relative decline in living standards in the periphery was due to long-term rural decline and involved spatial restructuring.

  10. Piracy in a Contested Periphery: Incorporation and the Emergence of the Modern World-System in the Colonial Atlantic Frontier

    Directory of Open Access Journals (Sweden)

    P. Nick Kardulias

    2016-08-01

    Full Text Available This article uses world-systems analysis to examine the role that pirates and privateers played in the competition between European core states in the Atlantic and Caribbean frontier during the seventeenth and eighteenth centuries. Piracy was an integral part of core-periphery interaction, as a force that nations could use against one another in the form of privateers, and as a reaction against increasing constraints on freedom of action by those same states, thus forming a semiperiphery. Although modern portrayals of pirates and privateers paint a distinct line between the two groups, historical records indicate that their actual status was rather fluid, with particular people moving back and forth between the two. As a result, the individuals were on a margin between legality and treason, often crossing from one to the other. In this study we discuss how pirates and privateers fit into the margins of society in the seventeenth and eighteenth centuries, also known as the Golden Age of Piracy, specifically using the example of Edward Teach, aka Blackbeard. The present analysis can contribute to our understanding not only of piracy, but also of the structure of peripheries and semiperipheries that in some ways reflect resistance to incorporation.

  11. Prosthetic avian vocal organ controlled by a freely behaving bird based on a low dimensional model of the biomechanical periphery.

    Directory of Open Access Journals (Sweden)

    Ezequiel M Arneodo

    Full Text Available Because of the parallels found with human language production and acquisition, birdsong is an ideal animal model to study general mechanisms underlying complex, learned motor behavior. The rich and diverse vocalizations of songbirds emerge as a result of the interaction between a pattern generator in the brain and a highly nontrivial nonlinear periphery. Much of the complexity of this vocal behavior has been understood by studying the physics of the avian vocal organ, particularly the syrinx. A mathematical model describing the complex periphery as a nonlinear dynamical system leads to the conclusion that nontrivial behavior emerges even when the organ is commanded by simple motor instructions: smooth paths in a low dimensional parameter space. An analysis of the model provides insight into which parameters are responsible for generating a rich variety of diverse vocalizations, and what the physiological meaning of these parameters is. By recording the physiological motor instructions elicited by a spontaneously singing muted bird and computing the model on a Digital Signal Processor in real-time, we produce realistic synthetic vocalizations that replace the bird's own auditory feedback. In this way, we build a bio-prosthetic avian vocal organ driven by a freely behaving bird via its physiologically coded motor commands. Since it is based on a low-dimensional nonlinear mathematical model of the peripheral effector, the emulation of the motor behavior requires light computation, in such a way that our bio-prosthetic device can be implemented on a portable platform.

  12. Decline, Adaptation or Transformation:New Perspectives on Demographic Change in Resource Peripheries in Australia and Sweden

    Directory of Open Access Journals (Sweden)

    Dean B. Carson

    2016-01-01

    Full Text Available Many sparsely populated resource peripheries in developed countries are perceived to suffer from periods of demographic decline due to loss of employment opportunities and services, youth out-migration and population ageing. While these trends tend to apply at broad regional scales and for particular time periods, diverse patterns of demographic change may be apparent if different spatial, temporal and social scales of analysis are taken into consideration. Comparing the experiences of two case study regions in northern Sweden and inland South Australia, this paper proposes an alternative conceptual framework to the “discourse of decline”, which could be used to examine the nuances of demographic change within resource peripheries. The framework includes spatial scale considerations that contrast broader regional demographic patterns with the experiences of sub-regions and individual settlements. It also includes temporal scale aspects, examining demographic change over different time periods to understand the pace, duration and frequency of population growth and decline. The framework finally includes social unit considerations, emphasising that demographic change affects different social groups in different ways. The results of the case studies suggest that considering demographic change as adaptation or transformation rather than decline may be more useful for identifying new – and qualitatively different – demographic pathways that emerge over time.

  13. Conceptualising 'knowledge management' in the context of library and information science using the core/periphery model

    Directory of Open Access Journals (Sweden)

    O.B. Onyancha

    2009-04-01

    Full Text Available This study took cognisance of the fact that the term 'knowledge management' lacks a universally accepted definition, and consequently sought to describe the term using the most common co-occurring terms in knowledge management (KM literature as indexed in the Library, Information Science and Technology Abstracts (LISTA database. Using a variety of approaches and analytic techniques (e.g. core/periphery analysis and co-occurrence of words as subject terms, data were analysed using the core/periphery model and social networks through UCINET for Windows, TI, textSTAT and Bibexcel computer-aided software. The study identified the following as the compound terms with which KM co-occurs most frequently: information resources management, information science, information technology, information services, information retrieval, library science, management information systems and libraries. The core single subject terms with which KM can be defined include resources, technology, libraries, systems, services, retrieval, storage, data and computers. The article concludes by offering the library and information science (LIS professionals' general perception of KM based on their use of terms, through which KM can be defined within the context of LIS.

  14. [Binocular coordination during reading].

    Science.gov (United States)

    Bassou, L; Granié, M; Pugh, A K; Morucci, J P

    1992-01-01

    Is there an effect on binocular coordination during reading of oculomotor imbalance (heterophoria, strabismus and inadequate convergence) and of functional lateral characteristics (eye preference and perceptually privileged visual laterality)? Recordings of the binocular eye-movements of ten-year-old children show that oculomotor imbalances occur most often among children whose left visual perceptual channel is privileged, and that these subjects can present optomotor dissociation and manifest lack of motor coordination. Close binocular motor coordination is far from being the norm in reading. The faster reader displays saccades of differing spatial amplitude and the slower reader an oculomotor hyperactivity, especially during fixations. The recording of binocular movements in reading appears to be an excellent means of diagnosing difficulties related to visual laterality and to problems associated with oculomotor imbalance.

  15. A Process Algebra for Supervisory Coordination

    Directory of Open Access Journals (Sweden)

    Jos Baeten

    2011-08-01

    Full Text Available A supervisory controller controls and coordinates the behavior of different components of a complex machine by observing their discrete behaviour. Supervisory control theory studies automated synthesis of controller models, known as supervisors, based on formal models of the machine components and a formalization of the requirements. Subsequently, code generation can be used to implement this supervisor in software, on a PLC, or embedded microprocessor. In this article, we take a closer look at the control loop that couples the supervisory controller and the machine. We model both event-based and state-based observations using process algebra and bisimulation-based semantics. The main application area of supervisory control that we consider is coordination, referred to as supervisory coordination, and we give an academic and an industrial example, discussing the process-theoretic concepts employed.

  16. Quantifying linguistic coordination

    DEFF Research Database (Denmark)

    Fusaroli, Riccardo; Tylén, Kristian

    task (Bahrami et al 2010, Fusaroli et al. 2012) we extend to linguistic coordination dynamical measures of recurrence employed in the analysis of sensorimotor coordination (such as heart-rate (Konvalinka et al 2011), postural sway (Shockley 2005) and eye-movements (Dale, Richardson and Kirkham 2012......). We employ nominal recurrence analysis (Orsucci et al 2005, Dale et al 2011) on the decision-making conversations between the participants. We report strong correlations between various indexes of recurrence and collective performance. We argue this method allows us to quantify the qualities...

  17. SENTINEL EVENTS

    Directory of Open Access Journals (Sweden)

    Andrej Robida

    2004-09-01

    Full Text Available Background. The Objective of the article is a two year statistics on sentinel events in hospitals. Results of a survey on sentinel events and the attitude of hospital leaders and staff are also included. Some recommendations regarding patient safety and the handling of sentinel events are given.Methods. In March 2002 the Ministry of Health introduce a voluntary reporting system on sentinel events in Slovenian hospitals. Sentinel events were analyzed according to the place the event, its content, and root causes. To show results of the first year, a conference for hospital directors and medical directors was organized. A survey was conducted among the participants with the purpose of gathering information about their view on sentinel events. One hundred questionnaires were distributed.Results. Sentinel events. There were 14 reports of sentinel events in the first year and 7 in the second. In 4 cases reports were received only after written reminders were sent to the responsible persons, in one case no reports were obtained. There were 14 deaths, 5 of these were in-hospital suicides, 6 were due to an adverse event, 3 were unexplained. Events not leading to death were a suicide attempt, a wrong side surgery, a paraplegia after spinal anaesthesia, a fall with a femoral neck fracture, a damage of the spleen in the event of pleural space drainage, inadvertent embolization with absolute alcohol into a femoral artery and a physical attack on a physician by a patient. Analysis of root causes of sentinel events showed that in most cases processes were inadequate.Survey. One quarter of those surveyed did not know about the sentinel events reporting system. 16% were having actual problems when reporting events and 47% beleived that there was an attempt to blame individuals. Obstacles in reporting events openly were fear of consequences, moral shame, fear of public disclosure of names of participants in the event and exposure in mass media. The majority of

  18. Event Modeling

    DEFF Research Database (Denmark)

    Bækgaard, Lars

    2001-01-01

    The purpose of this chapter is to discuss conceptual event modeling within a context of information modeling. Traditionally, information modeling has been concerned with the modeling of a universe of discourse in terms of information structures. However, most interesting universes of discourse...... are dynamic and we present a modeling approach that can be used to model such dynamics.We characterize events as both information objects and change agents (Bækgaard 1997). When viewed as information objects events are phenomena that can be observed and described. For example, borrow events in a library can...

  19. Study of seismic events in the Central Part of East European Platform

    Science.gov (United States)

    Gorbunova, Ella; Sanina, Irina; Ivanchenko, Galina; Nesterkina, Margarita; Konstantinovskaya, Natalya

    2015-04-01

    A measurement system for location seismic events in the Central Part of East European Platform is situated within the Mikhnevo Geophysical Observatory of the RAS Institute of Geospheres Dynamics and consists of 12 seismic stations. One vertical station is located in the center of the group in a shaft tunnel. The other stations are located on the periphery in three concentric circles and are almost equally spaced with regard to the terrain to ensure full azimuth coverage to the maximum extent possible. The unique array identifies events with a magnitude up to 3 at the distances until 1000 km within the Central Part of East European platform. Most of the events recorded by the Mikhnevo array at a distance of 60-500 km are man-made events represented by explosions in quarries during the development of mineral deposits. Long-term seismic records of explosions in quarries have been processed for the period from 2004 to 2014 to generate a database containing standard waveforms for each quarry. Some events of unknown origin appear in the records for this period; these do not correspond to the identified seismic forms for explosions in known quarries. Epicenter coordinates for these events do not match the coordinates of the known quarries. A cosmotectonic map of the Central Part of East European Platform was compiled during the studies using the LESSA software package (Lineament Extraction and Stripe Statistical Analysis) and data on the deep crustal structure, which made it possible to define the morphostructural plan and evaluate the geodynamic conditions in the area. The deep basement structure through the sedimentary cover is expressed in the surface texture of the area under study. The region's neotectonics is closely related to the history of deep structures, in particular, aulacogens extending in different directions, which may show in the contemporary morphostructural plan, mainly as inversion and partially inherited forms. Out of events of unknown nature

  20. Dimensions of Organizational Coordination

    DEFF Research Database (Denmark)

    Jensen, Andreas Schmidt; Aldewereld, Huib; Dignum, Virginia

    2013-01-01

    be supported to include organizational objectives and constraints into their reasoning processes by considering two alternatives: agent reasoning and middleware regulation. We show how agents can use an organizational specification to achieve organizational objectives by delegating and coordinating...... their activities with other agents in the society, using the GOAL agent programming language and the OperA organizational model....

  1. Reusability of coordination programs

    NARCIS (Netherlands)

    F. Arbab (Farhad); C.L. Blom (Kees); F.J. Burger (Freek); C.T.H. Everaars (Kees)

    1996-01-01

    textabstractIsolating computation and communication concerns into separate pure computation and pure coordination modules enhances modularity, understandability, and reusability of parallel and/or distributed software. This can be achieved by moving communication primitives (such as SendMessage and

  2. [Civilian-military coordination].

    Science.gov (United States)

    de Montravel, G

    2002-01-01

    Current humanitarian emergencies create complex, mutidimensional situations that stimulate simultaneous responses from a wide variety of sources including governments, non-governmental organizations (NGO), United Nations agencies, and private individuals. As a result, it has become essential to establish a coherent framework in which each actor can contribute promptly and effectively to the overall effort. This is the role of the United Nations Office for the Coordination of Humanitarian Affairs. Regardless of the circumstances and level of coordination, cooperation and collaboration between humanitarian and military personnel, it is necessary to bear in mind their objectives. The purpose of humanitarian action is to reduce human suffering. The purpose of military intervention is to stop warfare. The author of this article will discuss the three major obstacles to civilian-military coordination (strategic, tactical, and operational). Operations cannot be conducted smoothly and differences cannot be ironed out without mutual respect between the two parties, an explicit definition of their respective duties and responsibilities, a clear understanding of their cultural differences, and the presence of an organization and facilities for coordination and arbitrage by a neutral referee.

  3. Coordination of hand shape.

    Science.gov (United States)

    Pesyna, Colin; Pundi, Krishna; Flanders, Martha

    2011-03-09

    The neural control of hand movement involves coordination of the sensory, motor, and memory systems. Recent studies have documented the motor coordinates for hand shape, but less is known about the corresponding patterns of somatosensory activity. To initiate this line of investigation, the present study characterized the sense of hand shape by evaluating the influence of differences in the amount of grasping or twisting force, and differences in forearm orientation. Human subjects were asked to use the left hand to report the perceived shape of the right hand. In the first experiment, six commonly grasped items were arranged on the table in front of the subject: bottle, doorknob, egg, notebook, carton, and pan. With eyes closed, subjects used the right hand to lightly touch, forcefully support, or imagine holding each object, while 15 joint angles were measured in each hand with a pair of wired gloves. The forces introduced by supporting or twisting did not influence the perceptual report of hand shape, but for most objects, the report was distorted in a consistent manner by differences in forearm orientation. Subjects appeared to adjust the intrinsic joint angles of the left hand, as well as the left wrist posture, so as to maintain the imagined object in its proper spatial orientation. In a second experiment, this result was largely replicated with unfamiliar objects. Thus, somatosensory and motor information appear to be coordinated in an object-based, spatial-coordinate system, sensitive to orientation relative to gravitational forces, but invariant to grasp forcefulness.

  4. Block coordination copolymers

    Science.gov (United States)

    Koh, Kyoung Moo; Wong-Foy, Antek G; Matzger, Adam J; Benin, Annabelle I; Willis, Richard R

    2012-11-13

    The present invention provides compositions of crystalline coordination copolymers wherein multiple organic molecules are assembled to produce porous framework materials with layered or core-shell structures. These materials are synthesized by sequential growth techniques such as the seed growth technique. In addition, the invention provides a simple procedure for controlling functionality.

  5. Coordination failure caused by sunspots

    DEFF Research Database (Denmark)

    Beugnot, Julie; Gürgüç, Zeynep; Øvlisen, Frederik Roose

    2012-01-01

    on the efficient equilibrium, we consider sunspots as a potential reason for coordination failure. We conduct an experiment with a three player 2x2x2 game in which coordination on the efficient equilibrium is easy and should normally occur. In the control session, we find almost perfect coordination on the payoff......-dominant equilibrium, but in the sunspot treatment, dis-coordination is frequent. Sunspots lead to significant inefficiency, and we conclude that sunspots can indeed cause coordination failure....

  6. Quantum field theory in stationary coordinate systems

    International Nuclear Information System (INIS)

    Pfautsch, J.D.

    1981-01-01

    Quantum field theory is examined in stationary coordinate systems in Minkowski space. Preliminary to quantization of the scalar field, all of the possible stationary coordinate systems in flat spacetime are classified and explicitly constructed. Six distinct classes of such systems are found. Of these six, three have (identical) event horizons associated with them and five have Killing horizons. Two classes have distinct Killing and event horizons, with an intervening region analogous to the ergosphere in rotating black holes. Particular representatives of each class are selected for subsequent use in the quantum field theory. The scalar field is canonically quantized and a vacuum defined in each of the particular coordinate systems chosen. The vacuum states can be regarded as adapted to the six classes of stationary motions. There are only two vacuum states found, the Minkowski vacuum in those coordinate systems without event horizons and the Fulling vacuum in those with event horizons. The responses of monopole detectors traveling along stationary world lines are calculated in both the Minkowski and Fulling vacuums. The responses for each class of motions are distinct from those for every other class. A vacuum defined by the response of a detector must therefore not be equivalent in general to a vacuum defined by canonical quantization. Quantization of the scalar field within a rotating wedge is examined. It has not been possible to construct mode functions satisfying appropriate boundary conditions on the surface of the wedge. The asymptotic form of the renormalized stress tensor near the surfaces had been calculated and is found to include momentum terms which represent a circulation of energy within the wedge

  7. LIU 2011 event

    CERN Multimedia

    BE Department

    2011-01-01

    The LHC injectors upgrade (LIU) project was launched at the end of 2010 to coordinate the preparation of the CERN accelerator complex to meet the needs of the High Luminosity LHC (HL-LHC) until at least 2030. It should be completed by the end of the second long LHC shutdown, presently scheduled for 2018.   The goal of the LIU-2011 event is to present the status and plans of the LIU project, describing the needs and the actions foreseen in the different accelerators, from Linac4 to the PSB, PS and SPS.  

  8. [Adverse events prevention ability].

    Science.gov (United States)

    Aparo, Ugo Luigi; Aparo, Andrea

    2007-03-01

    The issue of how to address medical errors is the key to improve the health care system performances. Operational evidence collected in the last five years shows that the solution is only partially linked to future technological developments. Cultural and organisational changes are mandatory to help to manage and drastically reduce the adverse events in health care organisations. Classical management, merely based on coordination and control, is inadequate. Proactive, self-organising network based structures must be put in place and managed using adaptive, fast evolving management tools.

  9. Coordinating International Response to Emergencies

    International Nuclear Information System (INIS)

    Bice, S. D.

    2007-01-01

    count on them to bring to the field what they pledged to bring. Today's responses are too large in scope for any one entity to 'go it alone' and so on. It is just not possible to be successful if you stand alone in a disaster; we must share in the burden of response. Sometimes that means overcoming natural inclinations: governments must reach to the business community for help, non-governmental organizations must give up some of their autonomy to be successful on the ground, and governments must set aside differences in the face of overwhelming human need. Use of Incident Command: In all disasters there must be someone in charge and others must follow that command. Implementing a modified humanitarian incident command model is possible and would allow for the coordination and execution necessary to overcome obstacles in the field and disaster area of operation. Communication and IT Coordination: It is impossible to be successful in responding to a disaster if international radio frequencies and cell and line communications are not agreed to beforehand. Electronic data transfer and IT communication are equally important and must be agreed to before responders hit the ground. Modeling: understanding the maximum credible event scenario: Planning, characterizing the event in your country, determine the consequences based on the numbers of people potentially affected, loss of critical functionality, duration of this loss, replacement, economic impact, environmental impact and psychological (loss of confidence) impact. Exercises/Table Tops: And finally, of the utmost importance to success, cities, states, nations, NGOs, private businesses and so on. All who wish to help, must participate in exercises of their capabilities, of their plans to respond. Field exercises are best, but sitting around a table discussing roles and responsibilities is a first step which must be taken and taken today.(author)

  10. Irradiation of four pencils fuel element clusters in the periphery of OSIRIS. Qualification of the calculation method by dosimetry

    International Nuclear Information System (INIS)

    Alberman, A.; Morin, C.

    1983-09-01

    The programs of qualification of PWR fuels required many irradiations in research reactors. In the periphery of the OSIRIS reactor (70 MW), two devices (IRENE and ISABELLE loops) recreating the environment of the fuel rods in power reactors have been put into service. In each device a fuel element cluster including four pencils was irradiated. The problem set by dosimetry was to calculate the enrichments of the pencils to obtain the required power level and to compensate the neutron flux gradient (in front of/behind) to obtain the same power on each one of the four pencils. The required accuracy is about 5%. Fuels dosimetry achieved on loops mockups in the ISIS reactor allowed to test the validity of the calculations and to calibrate the probes according to the nuclear power [fr

  11. Material consumption and social well-being within the periphery of the world economy: an ecological analysis of maternal mortality.

    Science.gov (United States)

    Rice, James

    2008-12-01

    The degree to which social well-being is predicated upon levels of material consumption remains under-examined from a large-N, quantitative perspective. The present study analyzes the factors influencing levels of maternal mortality in 2005 among 92 peripheral countries. We incorporate into regression analysis the ecological footprint, a comprehensive measure of natural resource consumption, and alternative explanatory variables drawn from previous research. Results illustrate ecological footprint consumption has a moderately strong direct influence shaping lower levels of maternal mortality. Path analysis reveals export commodity concentration has a negative effect on level of ecological footprint demand net the strong positive influence of income per capita. This illustrates cross-national trade dependency relations directly influence natural resource consumption opportunities and thereby indirectly contribute to higher maternal mortality levels within the periphery of the world economy. The results confirm material consumption is an important dimension of improvement in maternal mortality.

  12. Nationality and Migration Status Generating Conflicts and Interpersonal Violence in a Neighborhood of the Urban Periphery of Cordoba

    Directory of Open Access Journals (Sweden)

    María José Magliano

    2015-12-01

    Full Text Available This paper analyses the implications of national origin and migration status in conflicts that reproduce forms of violence in a neighborhood of urban relegation (Wacquant, 2007, located in the Eastern periphery of Córdoba and mainly inhabited by Peruvian migrants. In addition, it looks into the forms and meanings of insecurity representations in these conflicts —in contexts of social exclusion— through considering the complex and contradictory practices and experiences of the people who live in those spaces. Methodologically, the paper is based on ethnographic research grounded in field observation, which attempts to understand how and why people in particular socio-historical scenarios act, think and feel as they do. It explores a topic scarcely developed yet in migration studies, that is the articulation between interpersonal violence, national origin and urban marginality.

  13. SU-G-206-03: CTDI Per KV at Phantom Center and Periphery: Comparison Between Major CT Manufacturers

    Energy Technology Data Exchange (ETDEWEB)

    Al-Senan, R [Columbia University Medical Center, New York, NY (United States); Demirkaya, O [King Faisal Specialist Hospital & Research Centre, Riyadh (Saudi Arabia)

    2016-06-15

    Purpose: The purpose of this study was to: 1) compare scanners output by measuring normalized CTDIw (mGy/100mAs) in different CT makes and models and at different kV’s, and 2) quantify the relationship between kV and CTDI and compare this relationship between the different manufacturers. Methods: Study included forty scanners of major CT manufacturers and of various models. Exposure was measured at center and 12 o’clock holes of head and body CTDI phantoms, at all available kV’s, and with the largest or second largest available collimation in each scanner. Average measured CTDI’s from each CT manufacturer were also plotted against kV and the fitting equation: CTDIw (normalized) = a.kVb was calculated. The power (b) value may be considered as an indicator of spectral filtration, which affects the degree of beam hardening. Also, HVLs were measured at several scanners. Results: Results showed GE scanners, on average, had higher normalized CTDIw than those of Siemens and Philips, in both phantom sizes and at all kV’s. ANOVA statistic indicated the difference was statistically significant (p < 0.05). Comparison between Philips and Siemens, however, was not statistically significant. Curve fitting showed b values ranged from 2.4 to 2.9 (for Head periphery and center, respectively); and was about 2.8 for Body phantom periphery, and 3.2 at the center of Body phantom. Fitting equations (kV vs. CTDI) will be presented and discussed. GE’s CTDIw vs. HVL showed very strong correlation (r > 0.99). Conclusion: Partial characterization of scanners output was performed which may be helpful in dose estimation to internal organs. The relatively higher output from GE scanners may be attributed to lower filtration. Work is still in progress to obtain CTDI values from other scanners as well as to measure their HVLs.

  14. Effect of the periphery of metal-semiconductor contacts with Schottky barriers on their static current-voltage characteristic

    International Nuclear Information System (INIS)

    Torkhov, N. A.

    2010-01-01

    Kelvin probe atomic-force microscopy of the electrostatic surface potential of gold Schottky contacts on n-GaAs showed that there is an extended transition area (halo) (tens of micrometers) around contacts in which the surface potential varies from the n-GaAs free surface potential to the gold contact surface potential. The contact potential and its distribution in the surrounding halo are controlled by the contact structure. The study of spreading currents showed that there is a high-conductance area (periphery) around the contact perimeter due to strong electric fields of the halo, which causes leakage currents. The conductivity of the main contact area is caused by 100- to 200-nm local areas with higher and lower conducting abilities. Mesa formation around contacts causes a decrease in the work function, a decrease in the halo extent and electric field strength, which is accompanied by spreading and decreasing of the peripheral area conductance. This results in disappearance of leakage currents and a decrease in the ideality index. In contrast, protection of the peripheral area by a SiO 2 insulating film 0.5 μm thick increases the work function, which is accompanied by the formation of potential lobes around the contact in two mutually perpendicular crystallographic directions. A stronger penetration of halo electric fields into the contact area results in an increase in the ideality index and disappearance of high-conductance peripheral area and leakage currents. The difference between the electrical properties of the periphery, gold grains, and their boundaries controls the contact switching mechanism when applying forward or reverse biases.

  15. Activation of somatostatin 2 receptors in the brain and the periphery induces opposite changes in circulating ghrelin levels: functional implications

    Directory of Open Access Journals (Sweden)

    Andreas eStengel

    2013-01-01

    Full Text Available Somatostatin is an important modulator of neurotransmission in the central nervous system and acts as a potent inhibitor of hormone and exocrine secretion and regulator of cell proliferation in the periphery. These pleiotropic actions occur through interaction with five G-protein coupled somatostatin receptor subtypes (sst1-5 that are widely expressed in the brain and peripheral organs. The characterization of somatostatin’s effects can be investigated by pharmacological or genetic approaches using newly developed selective sst agonists and antagonists and mice lacking specific sst subtypes. Recent evidence points towards a divergent action of somatostatin in the brain and in the periphery to regulate circulating levels of ghrelin, an orexigenic hormone produced by the endocrine X/A-like cells in the gastric mucosa. Somatostatin interacts with the sst2 in the brain to induce an increase in basal ghrelin plasma levels and counteracts the visceral stress-related decrease in circulating ghrelin in rats. By contrast, stimulation of peripheral somatostatin-sst2 signaling results in the inhibition of basal ghrelin release and mediates the postoperative decrease in circulating ghrelin in rats. The peripheral sst2-mediated reduction of plasma ghrelin is likely to involve a paracrine action of D-cell derived somatostatin acting on sst2 bearing X/A-like ghrelin cells in the gastric mucosa. The other member of the somatostatin family, named cortistatin, in addition to binding to sst1-5 also directly interacts with the ghrelin receptor and therefore may simultaneously modulate ghrelin release and actions at target sites bearing ghrelin receptors representing a link between the ghrelin and somatostatin systems.

  16. Nova Event Logging System

    International Nuclear Information System (INIS)

    Calliger, R.J.; Suski, G.J.

    1981-01-01

    Nova is a 200 terawatt, 10-beam High Energy Glass Laser currently under construction at LLNL. This facility, designed to demonstrate the feasibility of laser driven inertial confinement fusion, contains over 5000 elements requiring coordinated control, data acquisition, and analysis functions. The large amounts of data that will be generated must be maintained over the life of the facility. Often the most useful but inaccessible data is that related to time dependent events associated with, for example, operator actions or experiment activity. We have developed an Event Logging System to synchronously record, maintain, and analyze, in part, this data. We see the system as being particularly useful to the physics and engineering staffs of medium and large facilities in that it is entirely separate from experimental apparatus and control devices. The design criteria, implementation, use, and benefits of such a system will be discussed

  17. Improving Project Manufacturing Coordination

    Directory of Open Access Journals (Sweden)

    Korpivaara Ville

    2014-09-01

    Full Text Available The objective of this research is to develop firms’ project manufacturing coordination. The development will be made by centralizing the manufacturing information flows in one system. To be able to centralize information, a deep user need assessment is required. After user needs have been identified, the existing system will be developed to match these needs. The theoretical background is achieved through exploring the literature of project manufacturing, development project success factors and different frameworks and tools for development project execution. The focus of this research is rather in customer need assessment than in system’s technical expertise. To ensure the deep understanding of customer needs this study is executed by action research method. As a result of this research the information system for project manufacturing coordination was developed to respond revealed needs of the stakeholders. The new system improves the quality of the manufacturing information, eliminates waste in manufacturing coordination processes and offers a better visibility to the project manufacturing. Hence it provides a solid base for the further development of project manufacturing.

  18. Universal mechatronics coordinator

    Science.gov (United States)

    Muir, Patrick F.

    1999-11-01

    Mechatronic systems incorporate multiple actuators and sensor which must be properly coordinated to achieve the desired system functionality. Many mechatronic systems are designed as one-of-a-kind custom projects without consideration for facilitating future system or alterations and extensions to the current syste. Thus, subsequent changes to the system are slow, different, and costly. It has become apparent that manufacturing processes, and thus the mechatronics which embody them, need to be agile in order to more quickly and easily respond to changing customer demands or market pressures. To achieve agility, both the hardware and software of the system need to be designed such that the creation of new system and the alteration and extension of current system is fast and easy. This paper describes the design of a Universal Mechatronics Coordinator (UMC) which facilitates agile setup and changeover of coordination software for mechatronic systems. The UMC is capable of sequencing continuous and discrete actions that are programmed as stimulus-response pairs, as state machines, or a combination of the two. It facilitates the modular, reusable programing of continuous actions such as servo control algorithms, data collection code, and safety checking routines; and discrete actions such as reporting achieved states, and turning on/off binary devices. The UMC has been applied to the control of a z- theta assembly robot for the Minifactory project and is applicable to a spectrum of widely differing mechatronic systems.

  19. Coordinator, Translation Services | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Coordinator, Translation Services coordinates the overall operations of the ... services in IDRC by acting as the main resource person for internal clients ... all operational issues in order to ensure good quality products delivered on time.

  20. Recursive Advice for Coordination

    DEFF Research Database (Denmark)

    Terepeta, Michal Tomasz; Nielson, Hanne Riis; Nielson, Flemming

    2012-01-01

    Aspect-oriented programming is a programming paradigm that is often praised for the ability to create modular software and separate cross-cutting concerns. Recently aspects have been also considered in the context of coordination languages, offering similar advantages. However, introducing aspects...... challenging. This is important since ensuring that a system does not contain errors is often equivalent to proving that some states are not reachable. In this paper we show how to solve these challenges by applying a successful technique from the area of software model checking, namely communicating pushdown...

  1. Improving operating room coordination: communication pattern assessment.

    Science.gov (United States)

    Moss, Jacqueline; Xiao, Yan

    2004-02-01

    To capture communication patterns in operating room (OR) management to characterize the information needs of OR coordination. Technological applications can be used to change system processes to improve communication and information access, thereby decreasing errors and adverse events. The successful design of such applications relies on an understanding of communication patterns among healthcare professionals. Charge nurse communication was observed and documented at four OR suites at three tertiary hospitals. The data collection tool allowed rapid coding of communication patterns in terms of duration, mode, target person, and the purpose of each communication episode. Most (69.24%) of the 2074 communication episodes observed occurred face to face. Coordinating equipment was the most frequently occurring purpose of communication (38.7%) in all suites. The frequency of other purposes in decreasing order were coordinating patient preparedness (25.7%), staffing (18.8%), room assignment (10.7%), and scheduling and rescheduling surgery (6.2%). The results of this study suggest that automating aspects of preparing patients for surgery and surgical equipment management has the potential to reduce information exchange, decreasing interruptions to clinicians and diminishing the possibility of adverse events in the clinical setting.

  2. Fusion events

    International Nuclear Information System (INIS)

    Aboufirassi, M; Angelique, J.C.; Bizard, G.; Bougault, R.; Brou, R.; Buta, A.; Colin, J.; Cussol, D.; Durand, D.; Genoux-Lubain, A.; Horn, D.; Kerambrun, A.; Laville, J.L.; Le Brun, C.; Lecolley, J.F.; Lefebvres, F.; Lopez, O.; Louvel, M.; Meslin, C.; Metivier, V.; Nakagawa, T.; Peter, J.; Popescu, R.; Regimbart, R.; Steckmeyer, J.C.; Tamain, B.; Vient, E.; Wieloch, A.; Yuasa-Nakagawa, K.

    1998-01-01

    The fusion reactions between low energy heavy ions have a very high cross section. First measurements at energies around 30-40 MeV/nucleon indicated no residue of either complete or incomplete fusion, thus demonstrating the disappearance of this process. This is explained as being due to the high amount o energies transferred to the nucleus, what leads to its total dislocation in light fragments and particles. Exclusive analyses have permitted to mark clearly the presence of fusion processes in heavy systems at energies above 30-40 MeV/nucleon. Among the complete events of the Kr + Au reaction at 60 MeV/nucleon the majority correspond to binary collisions. Nevertheless, for the most considerable energy losses, a class of events do occur for which the detected fragments appears to be emitted from a unique source. These events correspond to an incomplete projectile-target fusion followed by a multifragmentation. Such events were singled out also in the reaction Xe + Sn at 50 MeV/nucleon. For the events in which the energy dissipation was maximal it was possible to isolate an isotropic group of events showing all the characteristics of fusion nuclei. The fusion is said to be incomplete as pre-equilibrium Z = 1 and Z = 2 particles are emitted. The cross section is of the order of 25 mb. Similar conclusions were drown for the systems 36 Ar + 27 Al and 64 Zn + nat Ti. A cross section value of ∼ 20 mb was determined at 55 MeV/nucleon in the first case, while the measurement of evaporation light residues in the last system gave an upper limit of 20-30 mb for the cross section at 50 MeV/nucleon

  3. Dynamic and nucleolin-dependent localization of human cytomegalovirus UL84 to the periphery of viral replication compartments and nucleoli.

    Science.gov (United States)

    Bender, Brian J; Coen, Donald M; Strang, Blair L

    2014-10-01

    Protein-protein and protein-nucleic acid interactions within subcellular compartments are required for viral genome replication. To understand the localization of the human cytomegalovirus viral replication factor UL84 relative to other proteins involved in viral DNA synthesis and to replicating viral DNA in infected cells, we created a recombinant virus expressing a FLAG-tagged version of UL84 (UL84FLAG) and used this virus in immunofluorescence assays. UL84FLAG localization differed at early and late times of infection, transitioning from diffuse distribution throughout the nucleus to exclusion from the interior of replication compartments, with some concentration at the periphery of replication compartments with newly labeled DNA and the viral DNA polymerase subunit UL44. Early in infection, UL84FLAG colocalized with the viral single-stranded DNA binding protein UL57, but colocalization became less prominent as infection progressed. A portion of UL84FLAG also colocalized with the host nucleolar protein nucleolin at the peripheries of both replication compartments and nucleoli. Small interfering RNA (siRNA)-mediated knockdown of nucleolin resulted in a dramatic elimination of UL84FLAG from replication compartments and other parts of the nucleus and its accumulation in the cytoplasm. Reciprocal coimmunoprecipitation of viral proteins from infected cell lysates revealed association of UL84, UL44, and nucleolin. These results indicate that UL84 localization during infection is dynamic, which is likely relevant to its functions, and suggest that its nuclear and subnuclear localization is highly dependent on direct or indirect interactions with nucleolin. Importance: The protein-protein interactions among viral and cellular proteins required for replication of the human cytomegalovirus (HCMV) DNA genome are poorly understood. We sought to understand how an enigmatic HCMV protein critical for virus replication, UL84, localizes relative to other viral and cellular

  4. Ultra-Widefield Steering-Based Spectral-Domain Optical Coherence Tomography Imaging of the Retinal Periphery.

    Science.gov (United States)

    Choudhry, Netan; Golding, John; Manry, Matthew W; Rao, Rajesh C

    2016-06-01

    To describe the spectral-domain optical coherence tomography (SD OCT) features of peripheral retinal findings using an ultra-widefield (UWF) steering technique to image the retinal periphery. Observational study. A total of 68 patients (68 eyes) with 19 peripheral retinal features. Spectral-domain OCT-based structural features. Nineteen peripheral retinal features, including vortex vein, congenital hypertrophy of the retinal pigment epithelium, pars plana, ora serrata pearl, typical cystoid degeneration (TCD), cystic retinal tuft, meridional fold, lattice and cobblestone degeneration, retinal hole, retinal tear, rhegmatogenous retinal detachment, typical degenerative senile retinoschisis, peripheral laser coagulation scars, ora tooth, cryopexy scars (retinal tear and treated retinoblastoma scar), bone spicules, white without pressure, and peripheral drusen, were identified by peripheral clinical examination. Near-infrared scanning laser ophthalmoscopy images and SD OCT of these entities were registered to UWF color photographs. Spectral-domain OCT resolved structural features of all peripheral findings. Dilated hyporeflective tubular structures within the choroid were observed in the vortex vein. Loss of retinal lamination, neural retinal attenuation, retinal pigment epithelium loss, or hypertrophy was seen in several entities, including congenital hypertrophy of the retinal pigment epithelium, ora serrata pearl, TCD, cystic retinal tuft, meridional fold, lattice, and cobblestone degenerations. Hyporeflective intraretinal spaces, indicating cystoid or schitic fluid, were seen in ora serrata pearl, ora tooth, TCD, cystic retinal tuft, meridional fold, retinal hole, and typical degenerative senile retinoschisis. The vitreoretinal interface, which often consisted of lamellae-like structures of the condensed cortical vitreous near or adherent to the neural retina, appeared clearly in most peripheral findings, confirming its association with many low-risk and vision

  5. Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 signaling is required for migration of naive human T cells from the thymus to the periphery

    NARCIS (Netherlands)

    Resop, Rachel S.; Douaisi, Marc; Craft, Joshua; Jachimowski, Loes C. M.; Blom, Bianca; Uittenbogaart, Christel H.

    2016-01-01

    The mechanisms that govern the egress of mature thymocytes from the human thymus to the periphery remain understudied yet are of utmost importance to the field of basic immunology, as well as T-cell reconstitution in various immunodeficiencies. We examined the expression and function of

  6. Vehicle coordinated transportation dispatching model base on multiple crisis locations

    Science.gov (United States)

    Tian, Ran; Li, Shanwei; Yang, Guoying

    2018-05-01

    Many disastrous events are often caused after unconventional emergencies occur, and the requirements of disasters are often different. It is difficult for a single emergency resource center to satisfy such requirements at the same time. Therefore, how to coordinate the emergency resources stored by multiple emergency resource centers to various disaster sites requires the coordinated transportation of emergency vehicles. In this paper, according to the problem of emergency logistics coordination scheduling, based on the related constraints of emergency logistics transportation, an emergency resource scheduling model based on multiple disasters is established.

  7. Accessory nuclei revisited: the translocation of snRNPs from the germinal vesicle to the periphery of the future embryo.

    Science.gov (United States)

    Biliński, Szczepan M; Kloc, Małgorzata

    2002-03-01

    Oocytes of certain insects contain peculiar organelles termed accessory nuclei (AN). These organelles originate by budding off from the envelope of the oocyte nucleus and contain 1-2 dense inclusions immersed in a translucent ground substance. We have demonstrated that in the wasp Vespula germanica each inclusion consists of two elements: a spherical body, and a hemispherical structure composed of numerous 20-30 nm particles. Immunoelectron microscopy and whole-mount in situ hybridization have shown that the inclusions contain AgNOR-staining proteins, p80-coilin, Sm proteins, and small nuclear RNAs (snRNAs). These results indicate that the inclusions and hemispherical structures are homologous to Cajal bodies and B-snurposomes of Xenopus germinal vesicles, respectively. During previtellogenesis, AN (together with their Cajal bodies) migrate to the cortical ooplasm of the oocyte where they reside at least until the onset of embryogenesis. We suggest that AN are vehicles for the transport and localization of snRNPs to the periphery of the oocyte, i.e., to the region where the blastoderm of the embryo develops and where there is a requirement for a high concentration of RNA-processing factors.

  8. The Social Democrats of Scholarship: Austrian Imperial Peripheries and the Making of a Progressive Science of Nationality, 1885–1903

    Directory of Open Access Journals (Sweden)

    Thomas R. Prendergast

    2015-10-01

    Full Text Available To what extent and in what ways did the intellectual climate of Austria’s often ethnolinguistically heterogeneous borderlands contribute to the formation, institutionalization and diffusion of emerging social scientific discourses during the final decades of the 19th century? Investigating the intellectual exchange between two early proponents of folklore studies (Volkskunde—the Slavonian-German-Jewish Friedrich Salomon Krauss (1859–1938 and Bukovinian-German Raimund Friedrich Kaindl (1866–1930—this paper argues that imperial peripheries, while traditionally overlooked as sites of knowledge production, in fact played a pivotal role in the development of an important brand of “progressive” social scientific research, one defined by a critical stance toward the prevailing historicist paradigms of the time. These self-described “social democrats of scholarship” collaborated, both formally and informally, on a number of related theoretical projects aimed at disrupting the exclusionary narratives of the academic establishment and re-focusing scholarly attention on the sociological, rather than historical, character of ethnonational difference. In this way, the nationalities question spurred, both in the center and at the margins of the monarchy, the development of new sciences of nationality intended to sustain Austria’s imperial structure.

  9. Geoeconomic Uses of Global Warming: The “Green” Technological Revolution and the Role of the Semi-Periphery

    Directory of Open Access Journals (Sweden)

    Diego Hurtado

    2018-03-01

    Full Text Available While some semi-peripheral countries have seen renewable energies as an opportunity to build their industrial and technological capacities, core countries and global governance organizations have been promoting “green growth.” Since the 2008 global financial crisis, global warming has been used as a catalyst for big business. As the global economy may be entering the first stage of a “green” technology revolution, neo-Schumpeterian economists have regained visibility. We intend to show how, as a consequence of the lack of a world-systemic perspective, crucial inconsistencies arise in neo-Schumpeterian contributions that weaken their conceptualization of the role of non-core economies in technological change. We examine the case of the tortuous trajectory of wind energy in Argentina to show the specific organizational, institutional, and macroeconomic constraints faced by a semi-peripheral economy as it attempts to develop its own technological and industrial capacities. The neo-Schumpeterian view of the “green industrial revolution” must be understood as valid only for the core-economy subsystem, which seems to require as well polarization of the world-system through what we call “semi-peripheral neoliberalism,” a peripheralizing force upon the semi-periphery necessary in order to rejuvenate core economies.

  10. Bathymetric and velocimetric surveys at highway bridges crossing the Missouri and Mississippi Rivers on the periphery of Missouri, June 2014

    Science.gov (United States)

    Huizinga, Richard J.

    2015-01-01

    Bathymetric and velocimetric data were collected by the U.S. Geological Survey, in cooperation with the Missouri Department of Transportation, in the vicinity of 8 bridges at 7 highway crossings of the Missouri and Mississippi Rivers on the periphery of Missouri from June 3 to 11, 2014. A multibeam echosounder mapping system was used to obtain channel-bed elevations for river reaches ranging from 1,525 to 1,640 feet longitudinally, and extending laterally across the active channel from bank to bank during low- to moderate-flow conditions. These bathymetric surveys indicate the channel conditions at the time of the surveys and provide characteristics of scour holes that may be useful in the development of predictive guidelines or equations for scour holes. These data also may be useful to the Missouri Department of Transportation as a low- to moderate-flow comparison to help assess the bridges for stability and integrity issues with respect to bridge scour during floods.

  11. From posttrauma intervention to immunization of the social body: pragmatics and politics of a resilience program in Israel's periphery.

    Science.gov (United States)

    Friedman-Peleg, Keren; Goodman, Yehuda C

    2010-09-01

    This article traces a critical change in the professional therapy of posttraumatic stress disorder (PTSD): from treatment of a disorder borne by individuals to treatment of an anticipated disorder to be prevented by fortifying the entire population. A community resilience program in the city of Sderot in southern Israel, which has been subjected to Qassam rockets by its Palestinian neighbors across the border, serves as our case study. Drawing on an ethnographic study of this new therapeutic program, we analyze how the social body that the professionals attempt to immunize against trauma was treated. In particular, we follow the various practices used to expand the clinical. We found that the population was split into several groups on a continuum between the clinical and the preclinical, each receiving different treatment. Moreover, the social body managed according to this new form of PTSD was articulated through ethnic and geopolitical power relations between professionals from the country's center and professionals from its periphery, and between the professionals and the city's residents. Finally, we discuss how this Israeli case compares with other national sites of the growing globalization of PTSD, like Bali, Haiti and Ethiopia, which anthropologists have been exploring in recent years.

  12. Network Coordinator Report

    Science.gov (United States)

    Himwich, Ed; Strand, Richard

    2013-01-01

    This report includes an assessment of the network performance in terms of lost observing time for the 2012 calendar year. Overall, the observing time loss was about 12.3%, which is in-line with previous years. A table of relative incidence of problems with various subsystems is presented. The most significant identified causes of loss were electronics rack problems (accounting for about 21.8% of losses), antenna reliability (18.1%), RFI (11.8%), and receiver problems (11.7%). About 14.2% of the losses occurred for unknown reasons. New antennas are under development in the USA, Germany, and Spain. There are plans for new telescopes in Norway and Sweden. Other activities of the Network Coordinator are summarized.

  13. Coordinating Group report

    International Nuclear Information System (INIS)

    1994-01-01

    In December 1992, western governors and four federal agencies established a Federal Advisory Committee to Develop On-site Innovative Technologies for Environmental Restoration and Waste Management (the DOIT Committee). The purpose of the Committee is to advise the federal government on ways to improve waste cleanup technology development and the cleanup of federal sites in the West. The Committee directed in January 1993 that information be collected from a wide range of potential stakeholders and that innovative technology candidate projects be identified, organized, set in motion, and evaluated to test new partnerships, regulatory approaches, and technologies which will lead to improve site cleanup. Five working groups were organized, one to develop broad project selection and evaluation criteria and four to focus on specific contaminant problems. A Coordinating Group comprised of working group spokesmen and federal and state representatives, was set up to plan and organize the routine functioning of these working groups. The working groups were charged with defining particular contaminant problems; identifying shortcomings in technology development, stakeholder involvement, regulatory review, and commercialization which impede the resolution of these problems; and identifying candidate sites or technologies which could serve as regional innovative demonstration projects to test new approaches to overcome the shortcomings. This report from the Coordinating Group to the DOIT Committee highlights the key findings and opportunities uncovered by these fact-finding working groups. It provides a basis from which recommendations from the DOIT Committee to the federal government can be made. It also includes observations from two public roundtables, one on commercialization and another on regulatory and institutional barriers impeding technology development and cleanup

  14. Punishing the periphery

    DEFF Research Database (Denmark)

    Hagmann, Tobias

    2015-01-01

    campaigns employed strikingly similar military tactics against local communities. Combining historical accounts with oral testimonies collected among victims of state violence in the Ogaadeen Somali diaspora in the USA, this article draws attention to the distinct temporality and spatiality that emerges......This article scrutinizes dynamics and legacies of state violence by the imperial and current government against civilians in the Ethiopian Ogaden, between 1960 and 2010. While conflict dynamics in eastern Ethiopia underwent significant changes in the past half-century, successive counterinsurgency...... from repeat cycles of state violence....

  15. Punishing the periphery:

    DEFF Research Database (Denmark)

    Hagmann, Tobias

    2014-01-01

    This article scrutinizes dynamics and legacies of state violence by the imperial and current government against civilians in the Ethiopian Ogaden, between 1960 and 2010. While conflict dynamics in eastern Ethiopia underwent significant changes in the past half-century, successive counterinsurgency...... campaigns employed strikingly similar military tactics against local communities. Combining historical accounts with oral testimonies collected among victims of state violence in the Ogaadeen Somali diaspora in the USA, this article draws attention to the distinct temporality and spatiality that emerges...

  16. Coordinates in relativistic Hamiltonian mechanics

    International Nuclear Information System (INIS)

    Sokolov, S.N.

    1984-01-01

    The physical (covariant and measurable) coordinates of free particles and covariant coordinates of the center of inertia are found for three main forms of relativistic dynamics. In the point form of dynamics, the covariant coordinates of two directly interacting particles are found, and the equations of motion are brought to the explicitly covariant form. These equations are generalized to the case of interaction with an external electromagnetic field

  17. Impacts of traffic emissions on atmospheric particulate nitrate and organics at a downwind site on the periphery of Guangzhou, China

    Science.gov (United States)

    Qin, Yi Ming; Tan, Hao Bo; Jie Li, Yong; Schurman, Misha I.; Li, Fei; Canonaco, Francesco; Prévôt, André S. H.; Chan, Chak K.

    2017-09-01

    Particulate matter (PM) pollution on the peripheries of Chinese megacities can be as serious as in cities themselves. Given the substantial vehicular emissions in inner-city areas, the direct transport of primary PM (e.g., black carbon and primary organics) and effective formation of secondary PM from precursors (e.g., NOx and volatile organic compounds) can contribute to PM pollution in buffer zones between cities. To investigate how traffic emissions in inner-city areas impact these adjacent buffer zones, a suite of real-time instruments were deployed in Panyu, downwind from central Guangzhou, from November to December 2014. Nitrate mass fraction was higher on high-PM days, with the average nitrate-to-sulfate ratio increasing from around 0.35 to 1.5 as the PM mass concentration increased from 10 to 160 µg m-3. Particulate nitrate was strongly correlated with excess ammonium (([NH4+] / [SO42-] - 1.5) × [SO42-]), with higher concentrations in December than in November due to lower temperatures. The organic mass fraction was the highest across all PM1 levels throughout the campaign. While organic aerosols (OA) were dominated by secondary organic aerosols (SOA = semi-volatile oxygenated organic aerosols + low-volatility oxygenated organic aerosols) as a campaign average, freshly emitted hydrocarbon-like organic aerosols (HOA) contributed up to 40 % of OA during high-OA periods, which typically occurred at nighttime and contributed 23.8 to 28.4 % on average. This was due to daytime traffic restrictions on heavy-duty vehicles in Guangzhou, and HOA almost increased linearly with total OA concentration. SOA increased as odd oxygen (Ox = O3 + NO2) increased during the day due to photochemistry. A combination of nighttime traffic emissions and daytime photochemistry contributed to the buildup of PM in Panyu. The mitigation of PM pollution in inner-city areas by reducing vehicular traffic can potentially improve air quality in peripheral areas.

  18. Event Index - a LHCb Event Search System

    CERN Document Server

    INSPIRE-00392208; Kazeev, Nikita; Redkin, Artem

    2015-12-23

    LHC experiments generate up to $10^{12}$ events per year. This paper describes Event Index - an event search system. Event Index's primary function is quickly selecting subsets of events from a combination of conditions, such as the estimated decay channel or stripping lines output. Event Index is essentially Apache Lucene optimized for read-only indexes distributed over independent shards on independent nodes.

  19. Distributed sensor coordination for advanced energy systems

    Energy Technology Data Exchange (ETDEWEB)

    Tumer, Kagan [Oregon State Univ., Corvallis, OR (United States). School of Mechanical, Industrial and Manufacturing Engineering

    2015-03-12

    Motivation: The ability to collect key system level information is critical to the safe, efficient and reliable operation of advanced power systems. Recent advances in sensor technology have enabled some level of decision making directly at the sensor level. However, coordinating large numbers of sensors, particularly heterogeneous sensors, to achieve system level objectives such as predicting plant efficiency, reducing downtime or predicting outages requires sophisticated coordination algorithms. Indeed, a critical issue in such systems is how to ensure the interaction of a large number of heterogenous system components do not interfere with one another and lead to undesirable behavior. Objectives and Contributions: The long-term objective of this work is to provide sensor deployment, coordination and networking algorithms for large numbers of sensors to ensure the safe, reliable, and robust operation of advanced energy systems. Our two specific objectives are to: 1. Derive sensor performance metrics for heterogeneous sensor networks. 2. Demonstrate effectiveness, scalability and reconfigurability of heterogeneous sensor network in advanced power systems. The key technical contribution of this work is to push the coordination step to the design of the objective functions of the sensors, allowing networks of heterogeneous sensors to be controlled. By ensuring that the control and coordination is not specific to particular sensor hardware, this approach enables the design and operation of large heterogeneous sensor networks. In addition to the coordination coordination mechanism, this approach allows the system to be reconfigured in response to changing needs (e.g., sudden external events requiring new responses) or changing sensor network characteristics (e.g., sudden changes to plant condition). Impact: The impact of this work extends to a large class of problems relevant to the National Energy Technology Laboratory including sensor placement, heterogeneous sensor

  20. Coordination of Conditional Poisson Samples

    Directory of Open Access Journals (Sweden)

    Grafström Anton

    2015-12-01

    Full Text Available Sample coordination seeks to maximize or to minimize the overlap of two or more samples. The former is known as positive coordination, and the latter as negative coordination. Positive coordination is mainly used for estimation purposes and to reduce data collection costs. Negative coordination is mainly performed to diminish the response burden of the sampled units. Poisson sampling design with permanent random numbers provides an optimum coordination degree of two or more samples. The size of a Poisson sample is, however, random. Conditional Poisson (CP sampling is a modification of the classical Poisson sampling that produces a fixed-size πps sample. We introduce two methods to coordinate Conditional Poisson samples over time or simultaneously. The first one uses permanent random numbers and the list-sequential implementation of CP sampling. The second method uses a CP sample in the first selection and provides an approximate one in the second selection because the prescribed inclusion probabilities are not respected exactly. The methods are evaluated using the size of the expected sample overlap, and are compared with their competitors using Monte Carlo simulation. The new methods provide a good coordination degree of two samples, close to the performance of Poisson sampling with permanent random numbers.

  1. Coordination in continuously repeated games

    NARCIS (Netherlands)

    Weeren, A.J.T.M.; Schumacher, J.M.; Engwerda, J.C.

    1995-01-01

    In this paper we propose a model to describe the effectiveness of coordination in a continuously repeated two-player game. We study how the choice of a decision rule by a coordinator affects the strategic behavior of the players, resulting in more or less cooperation. Our model requires the analysis

  2. Coordinated Transportation: Problems and Promise?

    Science.gov (United States)

    Fickes, Michael

    1998-01-01

    Examines the legal, administrative, and logistical barriers that have prevented the wide acceptance of coordinating community and school transportation services and why these barriers may be breaking down. Two examples of successful implementation of coordinated transportation are examined: employing a single system to serve all transportation…

  3. Bare coordination: the semantic shift

    NARCIS (Netherlands)

    de Swart, Henriette; Le Bruyn, Bert

    2014-01-01

    This paper develops an analysis of the syntax-semantics interface of two types of split coordination structures. In the first type, two bare singular count nouns appear as arguments in a coordinated structure, as in bride and groom were happy. We call this the N&N construction. In the second type,

  4. Multipole structure and coordinate systems

    International Nuclear Information System (INIS)

    Burko, Lior M

    2007-01-01

    Multipole expansions depend on the coordinate system, so that coefficients of multipole moments can be set equal to zero by an appropriate choice of coordinates. Therefore, it is meaningless to say that a physical system has a nonvanishing quadrupole moment, say, without specifying which coordinate system is used. (Except if this moment is the lowest non-vanishing one.) This result is demonstrated for the case of two equal like electric charges. Specifically, an adapted coordinate system in which the potential is given by a monopole term only is explicitly found, the coefficients of all higher multipoles vanish identically. It is suggested that this result can be generalized to other potential problems, by making equal coordinate surfaces adapt to the potential problem's equipotential surfaces

  5. Simulating events

    Energy Technology Data Exchange (ETDEWEB)

    Ferretti, C; Bruzzone, L [Techint Italimpianti, Milan (Italy)

    2000-06-01

    The Petacalco Marine terminal on the Pacific coast in the harbour of Lazaro Carclenas (Michoacan) in Mexico, provides coal to the thermoelectric power plant at Pdte Plutarco Elias Calles in the port area. The plant is being converted from oil to burn coal to generate 2100 MW of power. The article describes the layout of the terminal and equipment employed in the unloading, coal stacking, coal handling areas and the receiving area at the power plant. The contractor Techint Italimpianti has developed a software system, MHATIS, for marine terminal management which is nearly complete. The discrete event simulator with its graphic interface provides a real-type decision support system for simulating changes to the terminal operations and evaluating impacts. The article describes how MHATIS is used. 7 figs.

  6. The iris signal: blue periphery, tan collaret and freckles pattern - strong indicators for epidermal skin cancer in South-Eastern Europe.

    Science.gov (United States)

    Grigore, M; Furtunescu, F; Minca, D; Costache, M; Garbe, C; Simionescu, O

    2018-03-10

    Eye and skin share the embryological origin. Both are established risk factors in epidermal skin cancer. There are few reports using iris colour classification scales, most of them analyse colour in general or are too complex to use in daily practice. To investigate which iris colour pattern is associated with epidermal skin cancer in a S-E European Caucasian population. A case-control study was conducted on 480 patients: 229 skin cancers patients and 251 controls (dermatological patients free of skin cancers) admitted in two medical clinics of Dermatology in Bucharest, between October 2011 and May 2014. High-resolution iris photographs were taken for each patient. Three parameters of the iris were analysed individually and in association patterns for each patient: periphery, collaret and freckles. The most frequent iris colour pattern associated with epidermal skin cancer was blue periphery with light brown collaret and freckles present. In terms of individual parameters, the strongest indicators for skin cancer patients were blue periphery and blue collaret. The results of this study sustain the hypothesis that blue periphery with light brown collaret and freckles iris pattern is a reliable phenotypic marker for epidermal skin cancer. The results of this study differ from previous reports in which skin cancer risk was associated with a homogeneous blue iris. We account these differences in the characteristics of the recruited patients (S-E European, skin type II and III). The assessment of iris colour patterns is an easy and inexpensive detection tool in skin cancer risk assessment. © 2018 European Academy of Dermatology and Venereology.

  7. Dark and Photoinduced Cytotoxic Activity of the New Chlorophyll-a Derivatives with Oligoethylene Glycol Substituents on the Periphery of Their Macrocycles

    OpenAIRE

    Yana I. Pylina; Dmitry M. Shadrin; Oksana G. Shevchenko; Olga M. Startseva; Igor O. Velegzhaninov; Dmitry V. Belykh; Ilya O. Velegzhaninov

    2017-01-01

    In the present work, we investigated the dark and photoinduced cytotoxic activity of the new chlorophyll-a derivatives which contain the substituents of oligoethylene glycol on the periphery of their macrocycles. These compounds were tested using human cell lines to estimate their potential as photosensitizers for photodynamic therapy of cancer. It was shown that all the tested compounds have expressed photoinduced cytotoxic activity in vitro. Detailed study of the biological activity of one ...

  8. Event generators

    International Nuclear Information System (INIS)

    Durand, D.; Gulminelli, F.; Lopez, O.; Vient, E.

    1998-01-01

    The results concerning the heavy ion collision simulations at Fermi energies by means of phenomenological models obtained in the last two years ar presented. The event generators are essentially following the phase of elaboration of analysis methods of data obtained by INDRA or NAUTILUS 4 π multidetectors. To identify and correctly quantify a phenomenon or a physical quantity it is necessary to verify by simulation the feasibility and validity of the analysis and also to estimate the bias introduced by the experimental filter. Many studies have shown this, for instance: the determination of the collision reaction plan for flow studies, determination of kinematical characteristics of the quasi-projectiles, and the excitation energy measurement stored in the hot nuclei. To Eugene, the currently utilised generator, several improvements were added: introduction of space-time correlations between the different products emitted in the decay of excited nuclei by calculating the trajectories of the particles in the final phase of the reaction; taking into account in the decay cascade of the discrete levels of the lighter fragments; the possibility of the schematically description of the explosion of the nucleus by simultaneous emission of multi-fragments. Thus, by comparing the calculations with the data relative to heavy systems studied with the NAUTILUS assembly it was possible to extract the time scales in the nuclear fragmentation. The utilisation of these event generators was extended to the analysis of INDRA data concerning the determination of the vaporization threshold in the collisions Ar + Ni and also the research of the expansion effects in the collisions Xe + Sn at 50 MeV/u

  9. Adaptive coordination in surgical teams: an interview study.

    Science.gov (United States)

    Bogdanovic, Jasmina; Perry, Juliana; Guggenheim, Merlin; Manser, Tanja

    2015-04-01

    Effective teamwork has been recognised as a major contributor to safe patient care in surgery. Previous research has highlighted the importance of adaptive coordination for effective performance in acute care settings. Expanding this line of research this study explores the coordination behaviours and adaptive coordination strategies employed by surgical teams and identifies relevant situational characteristics influencing those coordination processes. We conducted a qualitative content analysis of semi-structured interviews with 33 surgical team members (nurses and physicians) from different specialties and hospitals. We identified coordination behaviours (i.e. task management, information management, teaching and leadership) and adaptive coordination strategies triggered by varying requirements due to non-routine events, intraoperative complications and differing level of experience among operating room staff. Interviewees highlighted the importance of effectively managing challenging moments and the supporting effect of positive climate on teamwork. This study complements previous research on the non-technical skills underpinning safe performance in surgical teams. It highlights the central role of coordination and points out the ways in which situational variability requires the team to behave adaptively.

  10. The crisis of the core seen through the eyes of the periphery: A Schelling model of the global-south megacity and the European crisis

    Directory of Open Access Journals (Sweden)

    Dymski Gary A.

    2013-01-01

    Full Text Available Adapting Schelling’s checker-board discrimination framework, we develop a disequilibrium model to examine growth in two core-periphery settings: global-South megacities and the Eurozone. Regarding megacities, informal sector growth undercuts the government’s capacity to fund fully adequate public services. Regarding the Eurozone, an increase in the relative size of the periphery will - under the government’s balanced-budget constraint - undercut the provision of public safety-net and infrastructure services. And if low-wage production is initiated in the European periphery, the core is likely to collapse. “Urbanization is decisive because it is so expensive. The difference between the costs of urban development and rural development does not turn on comparing the capital required for factories and that required for farms. Each of these is a small part of total investment, and the difference per head is not always in favor of industry. The difference turns on infrastructure.” W. Arthur Lewis (1977, pp. 39-40.

  11. Events diary

    Science.gov (United States)

    2000-01-01

    as Imperial College, the Royal Albert Hall, the Royal College of Art, the Natural History and Science Museums and the Royal Geographical Society. Under the heading `Shaping the future together' BA2000 will explore science, engineering and technology in their wider cultural context. Further information about this event on 6 - 12 September may be obtained from Sandra Koura, BA2000 Festival Manager, British Association for the Advancement of Science, 23 Savile Row, London W1X 2NB (tel: 0171 973 3075, e-mail: sandra.koura@britassoc.org.uk ). Details of the creating SPARKS events may be obtained from creating.sparks@britassoc.org.uk or from the website www.britassoc.org.uk . Other events 3 - 7 July, Porto Alegre, Brazil VII Interamerican conference on physics education: The preparation of physicists and physics teachers in contemporary society. Info: IACPE7@if.ufrgs.br or cabbat1.cnea.gov.ar/iacpe/iacpei.htm 27 August - 1 September, Barcelona, Spain GIREP conference: Physics teacher education beyond 2000. Info: www.blues.uab.es/phyteb/index.html

  12. Coordinating distributed work : Exploring situated coordination with gaming-simulation

    NARCIS (Netherlands)

    van Laere, J.

    2003-01-01

    Organizational work has become more and more distributed nowadays. Information and communication technologies (ICT) provide opportunities to improve coordination of distributed work, but in practice many organizations struggle with integrating new organizational structures, new work practices and

  13. Geophysical events

    Science.gov (United States)

    This is a summary of SEAN Bulletin, 13(3), March 31, 1988, a publication of the Smithsonian Institution's Scientific Event Alert Network. The complete bulletin is available in the microfiche edition of Eos as a microfiche supplement or as a paper reprint. For the microfiche, order document E88-002 at $2.50 (U.S.) by writing to AGU Orders, 2000 Florida Avenue, N.W., Washington, DC 20009 or by calling toll free on 800-424-2488. For the paper reprint, order SEAN Bulletin (giving volume and issue numbers and issue date) through the same address; the price is $3.50 for one copy of each issue number for those who do not have a deposit account, $2 for those who do; additional copies of each issue number are $1. Subscriptions to SEAN Bulletin are also available from AGU-Orders; the price is $18 for 12 monthly issues mailed to a U.S. address, $28 if mailed elsewhere, and must be prepaid.

  14. The coordinate transforming in geography information system

    International Nuclear Information System (INIS)

    Zhao Xiang; Chen Gang

    2003-01-01

    The coordinate transforming of geography information system includes two kinds of transforming, map projection and coordinate-transforming. This paper proposed a arithmetic of coordinate-transforming, it implement the transforming between the longitude-latitude coordinate and the screen coordinate and apply it in the GIS. The preferable effect was made. (authors)

  15. Who matters in coordination problems?

    Czech Academy of Sciences Publication Activity Database

    Sákovics, J.; Steiner, Jakub

    2012-01-01

    Roč. 102, č. 7 (2012), s. 3439-3461 ISSN 0002-8282 Institutional support: RVO:67985998 Keywords : coordination problem s * heterogeneous agents Subject RIV: AH - Economics Impact factor: 2.792, year: 2012

  16. Coordination Processes in International Organisations

    DEFF Research Database (Denmark)

    Nedergaard, Peter

    2008-01-01

    The EU is not a member of the International Labour Organisation (ILO), but relatively elaborate EU coordination takes place anyway. This paper addresses two research questions: 1) How is it possible to evaluate the coordination of the EU in its specific observable configuration in the ILO?, and 2......-à-vis their principals, the Member States. The Commission is the leading agent in the phase leading up to the Conference; the Presidency then takes over. On the one hand, due to the Treaty obligations and their interpretations by the Court of Justice, both the Presidency and the Commission are kept within tight limits...... by the principals. On the other hand, both before and during the Conference, the Member States accept the so-called discursive coordination of the Commission, which seems to be of great (but often neglected) importance. Owing to the organisational set-up in which coordination takes place, the EU is able...

  17. Hall effect in noncommutative coordinates

    International Nuclear Information System (INIS)

    Dayi, Oemer F.; Jellal, Ahmed

    2002-01-01

    We consider electrons in uniform external magnetic and electric fields which move on a plane whose coordinates are noncommuting. Spectrum and eigenfunctions of the related Hamiltonian are obtained. We derive the electric current whose expectation value gives the Hall effect in terms of an effective magnetic field. We present a receipt to find the action which can be utilized in path integrals for noncommuting coordinates. In terms of this action we calculate the related Aharonov-Bohm phase and show that it also yields the same effective magnetic field. When magnetic field is strong enough this phase becomes independent of magnetic field. Measurement of it may give some hints on spatial noncommutativity. The noncommutativity parameter θ can be tuned such that electrons moving in noncommutative coordinates are interpreted as either leading to the fractional quantum Hall effect or composite fermions in the usual coordinates

  18. Future in actinoids coordination chemistry

    International Nuclear Information System (INIS)

    Kitazawa, Takafumi

    2006-01-01

    Actinoids coordination chemistry is concerned with spent nuclear fuel reprocessing, specifically with solid-state chemistry of nuclear fuels, separation process with radioactive substances, and geological disposal of high-level radioactive substances. In the 21st century, accumulation of minor actinides, Np, Am, Cm, and others will be realized according with the present program of nuclear energy development. The present article briefly introduces general properties of actinide elements, followed by their coordination chemistry compared with rare earths coordination chemistry. Special facility needed to treat actinoids as well as their chemistry is briefly explained, together with the specific experimental apparatus such as X-ray Absorption Fine Structure (XAFS) and time-resolved laser-induced fluorescence spectrometry (TRLFS) with synchrotron radiation facilities. The effect of coordination with actinoids in the environment chemistry is important in underground disposal of high-level radioactive wastes. For theoretical analysis of the results with actinoids chemistry, relativistic calculation is needed. (S. Ohno)

  19. Coordination theory and collaboration technology

    CERN Document Server

    Olson, Gary M; Smith, John B

    2001-01-01

    The National Science Foundation funded the first Coordination Theory and Collaboration Technology initiative to look at systems that support collaborations in business and elsewhere. This book explores the global revolution in human interconnectedness. It will discuss the various collaborative workgroups and their use in technology. The initiative focuses on processes of coordination and cooperation among autonomous units in human systems, in computer and communication systems, and in hybrid organizations of both systems. This initiative is motivated by three scientific issues which have been

  20. Path integrals in curvilinear coordinates

    International Nuclear Information System (INIS)

    Prokhorov, L.V.

    1984-01-01

    Integration limits are studied for presenting the path integral curvilinear coordinates. For spherical (and topoloqically equivalent) coordinates it is shown that in formulas involving classical action in the exponent integration over all variables should be carried out within infinite limits. Another peculiarity is associated with appearance of the operator q which provides a complete definition of the wave functions out of the physical region. arguments are given upporting the validity of the cited statament in the general case

  1. Three coordination compounds based on benzene tetracarboxylate ...

    Indian Academy of Sciences (India)

    YUNLONG WU

    nescence, considerable attention has been focused on the construction of coordination .... measurements were performed on ground powder samples at .... Figure 2. (a) Coordination environment of Co1 ion in compound 2. (b) Coordination.

  2. Managing interteam coordination within and between organizations

    NARCIS (Netherlands)

    de Vries, Thomas Arend

    2015-01-01

    To accomplish complex tasks and effectively respond to environmental contingencies, teams must coordinate task-related issues with other teams (i.e., interteam coordination). Regrettably, interteam coordination is often complicated by misunderstandings that can arise from differences in teams’

  3. Intelligent uranium fission converter for neutron production on the periphery of the nuclear reactor core (MARIA reactor in Swierk - Poland)

    Energy Technology Data Exchange (ETDEWEB)

    Gryzinski, M.A.; Wielgosz, M. [National Centre for Nuclear Research, Andrzeja Soltana 7, 05-400 Otwock-Swierk (Poland)

    2015-07-01

    The multipurpose, high flux research reactor MARIA in Otwock - Swierk is an open-pool type, water and beryllium moderated and graphite reflected. There are two not occupied experimental H1 and H2 horizontal channels with complex of empty rooms beside them. Making use of these two channels is not in conflict with other research or commercial employing channels. They can work simultaneously, moreover commercial channels covers the cost of reactor working. Such conditions give beneficial possibility of creating epithermal neutron stand for researches in various field at the horizontal channel H2 of MARIA reactor (co-organization of research at H1 channel is additionally planned). At the front of experimental channels the neutron flux is strongly thermalized - neutrons with energies above 0.625 eV constitute only ∼2% of the total flux. This thermalized neutron flux will be used to achieve high flux of epithermal neutrons at the level of 2x10{sup 9} n cm{sup -2}s{sup -1} by uranium neutron converter (fast neutron production - conversion of reactor core thermal neutrons to fast neutrons - and then filtering, moderating and finally cutting of unwanted gamma radiation). The intelligent converter will be placed in the reactor pool, near the front of the H2 channel. It will replace one graphite block at the periphery of MARIA graphite reflector. The converter will consist of 20 fuel elements - low enriched uranium plates. A fuel plate will be a part which will measure 110 mm wide by 380 mm long and will consist of a thin layer of uranium sealed between two aluminium plates. These plates, once assembled, form the fuel element used in converter. The plates will be positioned vertically. There are several important requirements which should be taken into account at the converter design stage: -maximum efficiency of the converter for neutrons conversion, -cooling of the converter need to be integrated with the cooling circuit of the reactor pool and if needed equipped with

  4. Motor coordination uses external spatial coordinates independent of developmental vision.

    Science.gov (United States)

    Heed, Tobias; Röder, Brigitte

    2014-07-01

    The constraints that guide bimanual movement coordination are informative about the processing principles underlying movement planning in humans. For example, symmetry relative to the body midline benefits finger and hand movements independent of hand posture. This symmetry constraint has been interpreted to indicate that movement coordination is guided by a perceptual code. Although it has been assumed implicitly that the perceptual system at the heart of this constraint is vision, this relationship has not been tested. Here, congenitally blind and sighted participants made symmetrical and non-symmetrical (that is, parallel) bimanual tapping and finger oscillation movements. For both groups, symmetrical movements were executed more correctly than parallel movements, independent of anatomical constraints like finger homology and hand posture. For the blind, the reliance on external spatial factors in movement coordination stands in stark contrast to their use of an anatomical reference frame in perceptual processing. Thus, the externally coded symmetry constraint evident in bimanual coordination can develop in the absence of the visual system, suggesting that the visual system is not critical for the establishment of an external-spatial reference frame in movement coordination. Copyright © 2014 Elsevier B.V. All rights reserved.

  5. Differential Impact of Interferon Regulatory Factor 7 in Initiation of the Type I Interferon Response in the Lymphocytic Choriomeningitis Virus-Infected Central Nervous System versus the Periphery

    DEFF Research Database (Denmark)

    Christensen, Jeanette Erbo; Fenger, Christina; Issazadeh-Navikas, Shohreh

    2012-01-01

    in the LCMV-infected CNS, whereas concurrent elimination of both factors markedly reduces the virus-induced host response. This is unlike the situation in the periphery, where deficiency of IRF7 almost eliminates the LCMV-induced production of the type I IFNs. This difference is seemingly related to the local...... environment, as peripheral production of type I IFNs is severely reduced in intracerebrally (i.c.) infected IRF7-deficient mice, which undergo a combined infection of the CNS and peripheral organs, such as spleen and lymph nodes. Interestingly, despite the redundancy of IRF7 in initiating the type I IFN...

  6. Power reactor events, May-June 1986

    International Nuclear Information System (INIS)

    Massaro, S.A.

    1986-12-01

    Power Reactor Events is a bi-monthly newsletter that compiles operating experience information about commercial nuclear power plants. This includes summaries of noteworthy events and listings and/or abstracts of USNRC and other documents that discuss safety-related or possible generic issues. It is intended to feed back some of the lessons learned from operational experience to the various plant personnel, i.e., managers, licensed reactor operators, training coordinators, and support personnel. Events at the following plants are reported: McGuire Unit 1; Susquehanna Units 1 and 2; Browns Ferry Units 1, 2, and 3; and River Bend Unit 1

  7. Demand Response Integration Through Agent-Based Coordination of Consumers in Virtual Power Plants

    DEFF Research Database (Denmark)

    Clausen, Anders; Umair, Aisha; Ma, Zheng

    2016-01-01

    of industrial loads. Coordination happens in response to Demand Response events, while considering local objectives in the industrial domain. We illustrate the applicability of our approach on a Virtual Power Plant scenario with three simulated greenhouses. The results suggest that the proposed design is able...... Power Plant design that is able to balance the demand of energy-intensive, industrial loads with the supply situation in the electricity grid. The proposed Virtual Power Plant design uses a novel inter-agent, multi-objective, multi-issue negotiation mechanism, to coordinate the electricity demands...... to coordinate the electricity demands of industrial loads, in compliance with external Demand Response events....

  8. Vaccine Adverse Events

    Science.gov (United States)

    ... for Biologics Evaluation & Research Vaccine Adverse Events Vaccine Adverse Events Share Tweet Linkedin Pin it More sharing ... in the primary immunization series in infants Report Adverse Event Report a Vaccine Adverse Event Contact FDA ( ...

  9. Federal interagency radiation policy coordination

    International Nuclear Information System (INIS)

    Young, A.L.

    1984-01-01

    The author discusses Federal interagency radiation policy coordination. The Committee on Interagency Radiation Research and Policy Coordination (CIRRPC) is explained as being dedicated to the success and forward motion of enhanced radiation research and policy coordination. Both CIRRPC and the Science Panel are staffed with Federal employees. Their expertise includes many and various radiation disciplines including cytogenetics, dosimetry, epidemiology, genetics, health physics, nuclear medicine, radiology, radiation carcinogenesis, and risk assessment. Ten scientific and technical issues in their preliminary order are presented: radioepidemiological tables; de minimis radiation levels; radon progeny health effects; occupational exposure registry; measurement, recording, and control of radiation; food irradiation; use of radiation in science, industry, and medicine; nonionizing radiation; and remedial actions

  10. An argument for VP coordination: scene-setting coordination and ...

    African Journals Online (AJOL)

    This article demonstrates the properties of this curious construction type and proposes the first analysis to date. It is argued that this is an instance of VP coordination and that this configuration allows the possibility of high merger of direct objects in a constrained fashion. Southern African Linguistics and Applied Language ...

  11. Evaluating the Relational Coordination instrument

    DEFF Research Database (Denmark)

    Edwards, Kasper; Lundstrøm, Sanne Lykke

    2014-01-01

    consistency, interrater agreement and reliability, structural validity, content validity. However as relational coordination is being used as a diagnostics tool it is important to examine further if the instrument can measure changes. Indeed we need to know how precise and sensitive the instrument is when....... We distinguish between statistical and clinical significance. Statistical significance is calculated using T-test. Clinical significance is the minimal amount of change in relational coordination score that is not considered noise. Sensitivity of the instrument i.e. the ability of the instrument...

  12. Cation coordination in oxychloride glasses

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, J A [Energy Technology Division, Argonne National Laboratory, Argonne, IL (United States); Holland, D [Physics Department, Warwick University, Coventry (United Kingdom); Bland, J [Physics Department, University of Liverpool, PO Box 147, Liverpool (United Kingdom); Johnson, C E [Physics Department, Northern Illinois University, DeKalb, IL (United States); Thomas, M F [Physics Department, University of Liverpool, PO Box 147, Liverpool (United Kingdom)

    2003-02-19

    Glasses containing mixtures of cations and anions of nominal compositions [Sb{sub 2}O{sub 3}]{sub x} - [ZnCl{sub 2}]{sub 1-x} where x = 0.25, 0.50, 0.75, and 1.00, have been studied by means of neutron diffraction and Raman and Moessbauer spectroscopy. There is preferential bonding within the system with the absence of Sb-Cl bonds. Antimony is found to be threefold coordinated to oxygen, and zinc fourfold coordinated. The main contributing species are of the form [Sb(OSb){sub 2}(OZn)] and [Zn(ClZn){sub 2}(OSb){sub 2}].

  13. Cation coordination in oxychloride glasses

    International Nuclear Information System (INIS)

    Johnson, J A; Holland, D; Bland, J; Johnson, C E; Thomas, M F

    2003-01-01

    Glasses containing mixtures of cations and anions of nominal compositions [Sb 2 O 3 ] x - [ZnCl 2 ] 1-x where x = 0.25, 0.50, 0.75, and 1.00, have been studied by means of neutron diffraction and Raman and Moessbauer spectroscopy. There is preferential bonding within the system with the absence of Sb-Cl bonds. Antimony is found to be threefold coordinated to oxygen, and zinc fourfold coordinated. The main contributing species are of the form [Sb(OSb) 2 (OZn)] and [Zn(ClZn) 2 (OSb) 2

  14. Bare coordination: the semantic shift

    OpenAIRE

    de Swart, Henriette; Le Bruyn, Bert

    2014-01-01

    This paper develops an analysis of the syntax-semantics interface of two types of split coordination structures. In the first type, two bare singular count nouns appear as arguments in a coordinated structure, as in bride and groom were happy. We call this the N&N construction. In the second type, the determiner shows agreement with the first conjunct, while the second conjunct is bare, as in the Spanish example el hornero y hornera cobraban en panes (‘thesg.m bakersg.m and bakersg.f werepl p...

  15. Multifractal fluctuations in joint angles during infant spontaneous kicking reveal multiplicativity-driven coordination

    International Nuclear Information System (INIS)

    Stephen, Damian G.; Hsu, Wen-Hao; Young, Diana; Saltzman, Elliot L.; Holt, Kenneth G.; Newman, Dava J.; Weinberg, Marc; Wood, Robert J.; Nagpal, Radhika; Goldfield, Eugene C.

    2012-01-01

    Previous research has considered infant spontaneous kicking as a form of exploration. According to this view, spontaneous kicking provides information about motor degrees of freedom and may shape multijoint coordinations for more complex movement patterns such as gait. Recent work has demonstrated that multifractal, multiplicative fluctuations in exploratory movements index energy flows underlying perceptual-motor information. If infant spontaneous kicking is exploratory and occasions an upstream flow of information from the motor periphery, we expected not only that multiplicativity of fluctuations at the hip should promote multiplicativity of fluctuations at more distal joints (i.e., reflecting downstream effects of neural control) but also that multiplicativity at more distal joints should promote multiplicativity at the hip. Multifractal analysis demonstrated that infant spontaneous kicking in four typically developing infants for evidence of multiplicative fluctuations in multiple joint angles along the leg (i.e., hip, knee, and ankle) exhibited multiplicativity. Vector autoregressive modeling demonstrated that only one leg exhibited downstream effects but that both legs exhibited upstream effects. These results confirm the exploratory aspect of infant spontaneous kicking and suggest chaotic dynamics in motor coordination. They also resonate with existing models of chaos-controlled robotics and noise-based interventions for rehabilitating motor coordination in atypically developing patients.

  16. 47 CFR 95.1113 - Frequency coordinator.

    Science.gov (United States)

    2010-10-01

    ... SERVICES Wireless Medical Telemetry Service (WMTS) General Provisions § 95.1113 Frequency coordinator. (a) The Commission will designate a frequency coordinator(s) to manage the usage of the frequency bands for the operation of medical telemetry devices. (b) The frequency coordinator shall (1) Review and...

  17. 29 CFR 42.8 - Coordination plan.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Coordination plan. 42.8 Section 42.8 Labor Office of the Secretary of Labor COORDINATED ENFORCEMENT § 42.8 Coordination plan. (a) Based upon, among other things, the... coordination plan concerning farm labor-related responsibilities of the Department, including migrant housing...

  18. Service Coordination Policies and Models: National Status.

    Science.gov (United States)

    Harbin, Gloria L.; Bruder, M.; Mazzarella, C.; Gabbard, G.; Reynolds, C.

    This report discusses the findings of a study that investigated state coordination of early intervention services for infants, toddlers, and young children with disabilities. State Part C coordinators participated in a survey that sought their perceptions of values under girding service coordination, approach to service coordination, policies,…

  19. Diethylstilbestrol alters positive and negative selection of T cells in the thymus and modulates T-cell repertoire in the periphery

    International Nuclear Information System (INIS)

    Brown, Nicole; Nagarkatti, Mitzi; Nagarkatti, Prakash S.

    2006-01-01

    Prenatal exposure to diethylstilbestrol (DES) is known to cause altered immune functions and increased susceptibility to autoimmune disease in humans. In the current study, we investigated the effects of DES on T-cell differentiation in the thymus using the HY-TCR transgenic (Tg) mouse model in which the female mice exhibit positive selection of T cells bearing the Tg TCR, while the male mice show negative selection of such T cells. In female HY-TCR-Tg mice, exposure to DES showed more pronounced decrease in thymic cellularity when compared to male mice. Additionally, female mice also showed a significant decrease in the proportion of double-positive (DP) T cells in the thymus and HY-TCR-specific CD8 + T cells in the periphery. Male mice exhibiting negative selection also showed decreased thymic cellularity following DES exposure. Moreover, the male mice showed increased proportion of double-negative (DN) T cells in the thymus and decreased proportion of CD8 + T cells. The density of expression of HY-TCR on CD8 + cells was increased following DES exposure in both females and males. Finally, the proliferative response of thymocytes to mitogens and peripheral lymph node T cells to male H-Y antigen was significantly altered in female and male mice following DES treatment. Taken together, these data suggest that DES alters T-cell differentiation in the thymus by interfering with positive and negative selection processes, which in turn modulates the T-cell repertoire in the periphery

  20. [The expression of periphery blood leucocyte CCR3 and CCR5 in the children with Epstein-Barr virus associated infectious mononucleosis].

    Science.gov (United States)

    Qi, Tie-xiong; Gao, Guo-hua; Liu, Shi-hua

    2010-10-01

    To explore the expression of periphery blood leucocyte CCR3 and CCR5 and to comprehend T helper cell in the Children with Epstein-Barr virus associated infectious mononucleosis. We defined the children according to the diagnosis criterion through Paul-Bunnell test inspecting the children's periphery blood unusual lymphocyte and detecting their anti-EBV-CA-IgM, anti-EBV-CA-IgG and anti-EBV-NA-IgG by ELISA and counted the ratio of CCR3 + and CCR5 + cells in lymphocytes with flow cytometry. The ratio of unusual lymphocyte in IM was higher than that of the healthy control group (P < 0.05). The ratio of CCR3 + cells in IM group was higher than that of the healthy control group (P < 0.05). The ratio of CCR5 + cells in IM group was significantly lower than that of the healthy control group. CCR3 + had direct interrelation with fever continued time and the ratio of unusual lymphocyte. There was a negative interrelation between CCR5 and fever continued time (P < 0.05). Children infectious of IM expressed higher level of CCR3 + and lower level of CCR5 + and there was a tendency of Th2 polarization with over production of T helper cell divide imbalance. CCR3 + and CCR5 + may be important targets to judge the degree of seriousness of IM.

  1. A novel kinesin-like protein, KIF1Bbeta3 is involved in the movement of lysosomes to the cell periphery in non-neuronal cells.

    Science.gov (United States)

    Matsushita, Masafumi; Tanaka, Shingo; Nakamura, Norihiro; Inoue, Hiroki; Kanazawa, Hiroshi

    2004-03-01

    The kinesin superfamily protein, KIF1Bbeta, a splice variant of KIF1B, is involved in the transport of synaptic vesicles in neuronal cells, and is also expressed in various non-neuronal tissues. To elucidate the functions of KIF1Bbeta in non-neuronal cells, we analyzed the intracellular localization of KIF1Bbeta and characterized its isoform expression profile. In COS-7 cells, KIF1B colocalized with lysosomal markers and expression of a mutant form of KIF1Bbeta, lacking the motor domain, impaired the intracellular distribution of lysosomes. A novel isoform of the kinesin-like protein, KIF1Bbeta3, was identified in rat and simian kidney. It lacks the 5th exon of the KIF1Bbeta-specific tail region. Overexpression of KIF1Bbeta3 induced the translocation of lysosomes to the cell periphery. However, overexpression of KIF1Bbeta3-Q98L, which harbors a pathogenic mutation associated with a familial neuropathy, Charcot-Marie-Tooth disease type 2 A, resulted in the abnormal perinuclear clustering of lysosomes. These results indicate that KIF1Bbeta3 is involved in the translocation of lysosomes from perinuclear regions to the cell periphery.

  2. U.S. CWMD Coordination

    Science.gov (United States)

    2012-12-11

    coordination. For example, it conducted joint vehicle inspection training for Pakistani Customs and Border Guard personnel at a US- Mexico border...biological material, including such hazards as: anthrax, botulism, cholera , Ebola virus hemorrhagic fever, E. coli, Plague, and smallpox 79

  3. Collective coordinates on symplectic manifolds

    International Nuclear Information System (INIS)

    Razumov, A.V.; Taranov, A.Yu.

    1981-01-01

    For an arbitrary Lie group of canonical transformations on a symplectic manifold collective coordinates are introduced. They describe a motion of the dynamical system as a whole under the group transformations. Some properties of Lie group of canonical transformations are considered [ru

  4. Motivic amplitudes and cluster coordinates

    International Nuclear Information System (INIS)

    Golden, J.K.; Goncharov, A.B.; Spradlin, M.; Vergu, C.; Volovich, A.

    2014-01-01

    In this paper we study motivic amplitudes — objects which contain all of the essential mathematical content of scattering amplitudes in planar SYM theory in a completely canonical way, free from the ambiguities inherent in any attempt to choose particular functional representatives. We find that the cluster structure on the kinematic configuration space Conf n (ℙ 3 ) underlies the structure of motivic amplitudes. Specifically, we compute explicitly the coproduct of the two-loop seven-particle MHV motivic amplitude A 7,2 M and find that like the previously known six-particle amplitude, it depends only on certain preferred coordinates known in the mathematics literature as cluster X-coordinates on Conf n (ℙ 3 ). We also find intriguing relations between motivic amplitudes and the geometry of generalized associahedrons, to which cluster coordinates have a natural combinatoric connection. For example, the obstruction to A 7,2 M being expressible in terms of classical polylogarithms is most naturally represented by certain quadrilateral faces of the appropriate associahedron. We also find and prove the first known functional equation for the trilogarithm in which all 40 arguments are cluster X-coordinates of a single algebra. In this respect it is similar to Abel’s 5-term dilogarithm identity

  5. Co-ordinated Classroom Lectures.

    Science.gov (United States)

    Harmon, Darell Boyd

    From a series of lectures, a selection of eight are oriented principally toward the biologically developing child, and the physiological operations in visual process. The numbered lectures are--(1) The Coordinated Classroom, its Philosophy and Principles, (2) An Outline of a Biological Point of View, (3) The Evolution of Structure--despite man's…

  6. Henry Taube and Coordination Chemistry

    Science.gov (United States)

    dropdown arrow Site Map A-Z Index Menu Synopsis Henry Taube and Coordination Chemistry Resources with Professor of Chemistry, Emeritus, at Stanford University, received the 1983 Nobel Prize in Chemistry " there from 1940-41. "I became deeply interested in chemistry soon after I came to Berkeley,"

  7. Possibility of extending space-time coordinates

    International Nuclear Information System (INIS)

    Wang Yongcheng.

    1993-11-01

    It has been shown that one coordinate system can describe a whole space-time region except some supersurfaces on which there are coordinate singularities. The conditions of extending a coordinate from real field to complex field are studied. It has been shown that many-valued coordinate transformations may help us to extend space-time regions and many-valued metric functions may make one coordinate region to describe more than one space-time regions. (author). 11 refs

  8. Topology of Event Horizon

    OpenAIRE

    Siino, Masaru

    1997-01-01

    The topologies of event horizons are investigated. Considering the existence of the endpoint of the event horizon, it cannot be differentiable. Then there are the new possibilities of the topology of the event horizon though they are excluded in smooth event horizons. The relation between the topology of the event horizon and the endpoint of it is revealed. A torus event horizon is caused by two-dimensional endpoints. One-dimensional endpoints provide the coalescence of spherical event horizo...

  9. On coordinates and coordinate transformation in Einstein's theory of gravitation

    International Nuclear Information System (INIS)

    Chou Peiyuan

    1983-01-01

    This investigation is a further exposition of the significance of coordinates and their transformation in Einstein's theory of gravitation. The author considers the static axisymmetric field as an example, starts with its metric in the cylindrical coordinates, transforms this metric and the field equations into the Weyl-Levi-Civita system of coordinates, and supplements them with the harmonic condition. Both of the field equations and the harmonic condition are then transformed back to the original Cartesian system. Solutions for the static fields of an infinite plane with uniform surface density and an infinite rod with uniform linear density of matter, and of a body with spherical symmetry, are obtained again to show the necessity of the harmonic condition in their solutions. The fact that under the harmonic condition the solutions of the field equations for these problems contain their corresponding Newtonian potentials as approximations, is a strong support to the argument that the harmonic condition should be a physical supplement to Einstein's theory of gravitation. (Auth.)

  10. Event segmentation ability uniquely predicts event memory.

    Science.gov (United States)

    Sargent, Jesse Q; Zacks, Jeffrey M; Hambrick, David Z; Zacks, Rose T; Kurby, Christopher A; Bailey, Heather R; Eisenberg, Michelle L; Beck, Taylor M

    2013-11-01

    Memory for everyday events plays a central role in tasks of daily living, autobiographical memory, and planning. Event memory depends in part on segmenting ongoing activity into meaningful units. This study examined the relationship between event segmentation and memory in a lifespan sample to answer the following question: Is the ability to segment activity into meaningful events a unique predictor of subsequent memory, or is the relationship between event perception and memory accounted for by general cognitive abilities? Two hundred and eight adults ranging from 20 to 79years old segmented movies of everyday events and attempted to remember the events afterwards. They also completed psychometric ability tests and tests measuring script knowledge for everyday events. Event segmentation and script knowledge both explained unique variance in event memory above and beyond the psychometric measures, and did so as strongly in older as in younger adults. These results suggest that event segmentation is a basic cognitive mechanism, important for memory across the lifespan. Copyright © 2013 Elsevier B.V. All rights reserved.

  11. Main Directions for Accelerating Modernization in the Agricultural Sector in the Rural Periphery of the North (Case Study of the Komi Republic

    Directory of Open Access Journals (Sweden)

    Valentin Aleksandrovich Ivanov

    2015-07-01

    Full Text Available Agricultural production in the rural periphery of the North requires modernization because it is necessary to overcome the backwardness of its technical and technological level, to improve the provision of the population with local food products, to create competitive advantages in the local and regional markets, to use natural and human capital rationally, to raise the standard of living and quality of life of agricultural workers, to retain young people in rural areas, to reduce significant differentiation in socioeconomic development of remote and suburban areas. The period of market reforms was marked by the destruction of the material-technical base of agriculture, the sharp reduction in cultivated agricultural land, number of animals, number of workers, the deterioration of their professional level and quality of life, the decline in production of all kinds of agricultural products. In the period of market reforms the facilities and infrastructure basis of agriculture was destroyed, the volume of cultivated land reduced greatly, as well as the population of livestock, and the number of employees; their professional level and quality of life deteriorated, the production of all kinds of agricultural products reduced. Agriculture was deprived of possible technological re-equipment because of prices liberalization, the drastic reduction in state support and in the amount of investments. The article proves that current views on the lack of prospects for development of agricultural production in the rural periphery and the reorientation of rural residents on other activities are not acceptable. The authors point out the need to accelerate modernization in agriculture, and they conclude that sustainable agricultural and rural development is a long-term priority for the state and municipal authorities. The article considers the possibilities and necessity of intensifying modernization processes in the agricultural production of the rural periphery

  12. Enhancing response coordination through the assessment of response network structural dynamics.

    Directory of Open Access Journals (Sweden)

    Alireza Abbasi

    Full Text Available Preparing for intensifying threats of emergencies in unexpected, dangerous, and serious natural or man-made events, and consequent management of the situation, is highly demanding in terms of coordinating the personnel and resources to support human lives and the environment. This necessitates prompt action to manage the uncertainties and risks imposed by such extreme events, which requires collaborative operation among different stakeholders (i.e., the personnel from both the state and local communities. This research aims to find a way to enhance the coordination of multi-organizational response operations. To do so, this manuscript investigates the role of participants in the formed coordination response network and also the emergence and temporal dynamics of the network. By analyzing an inter-personal response coordination operation to an extreme bushfire event, the networks' and participants' structural change is evaluated during the evolution of the operation network over four time durations. The results reveal that the coordination response network becomes more decentralized over time due to the high volume of communication required to exchange information. New emerging communication structures often do not fit the developed plans, which stress the need for coordination by feedback in addition to by plan. In addition, we find that the participant's brokering role in the response operation network identifies a formal and informal coordination role. This is useful for comparison of network structures to examine whether what really happens during response operations complies with the initial policy.

  13. TURNAROUND COORDINATOR. YES OR NOT?

    Directory of Open Access Journals (Sweden)

    Martin HROMÁDKA

    2013-12-01

    Full Text Available Both low cost carriers ‘fresh wind’ and liberalisation of ground handling market makes airlines to be cost-wise in every single field. Thus, ground handling contract are cutting down in terms of their costs. Handling companies struggle with pressure being put from the market environment, they rush 25 minutes turnaround with couple of people. This can be potentially dangerous from the safety point of view. One of possible solutions seems to be introducing turnaround coordinator, person who would supervise the ramp handling procedures. This paper discusses the role of turnaround coordinator within the aircraft turnaround process. Duties and responsibilities of this person are described. However, not every airport is staffing this position. The survey shows that smaller airports pay much more attention to this issue than the big ones.

  14. A coordination language for databases

    DEFF Research Database (Denmark)

    Li, Ximeng; Wu, Xi; Lluch Lafuente, Alberto

    2017-01-01

    We present a coordination language for the modeling of distributed database applications. The language, baptized Klaim-DB, borrows the concepts of localities and nets of the coordination language Klaim but re-incarnates the tuple spaces of Klaim as databases. It provides high-level abstractions...... and primitives for the access and manipulation of structured data, with integrity and atomicity considerations. We present the formal semantics of Klaim-DB and develop a type system that avoids potential runtime errors such as certain evaluation errors and mismatches of data format in tables, which are monitored...... in the semantics. The use of the language is illustrated in a scenario where the sales from different branches of a chain of department stores are aggregated from their local databases. Raising the abstraction level and encapsulating integrity checks in the language primitives have benefited the modeling task...

  15. Coordinating talk and practical action

    DEFF Research Database (Denmark)

    Oshima, Sae; Streeck, Jürgen

    2015-01-01

    This paper investigates how talk and practical action are coordinated during one type of activity involving professional communication: the service-assessment sequence in hair salons. During this activity, a practical inspection of the haircut must be coupled with sequentially produced verbal acts....... Our analysis of four examples reveals that there is no fixed relationship between the organization of talk and practical action. Instead, people manipulate this relationship on a moment-by-moment basis, often coordinating the two into a single, integral package, or relying on one stream of action...... to achieve progress in the other. These findings imply that some multimodal activities that are brought into alignment may have their own, separate and independent procedural logic and sequencing patterns and that these can be brought into play to create or deal with constraints in each other....

  16. Improving Channel Coordination Through Franchising

    OpenAIRE

    Rajiv Lal

    1990-01-01

    In this paper, we explore the role of franchising arrangements in improving coordination between channel members. In particular we focus on two elements of the franchising contract, namely, the royalty structure and the monitoring technology. We begin with a simple analysis where a manufacturer distributes its product through a retailer and the retail demand is affected by the retail price and the service provided by the retailer. In this context we show that neither royalty payments nor moni...

  17. Coordination in the European Union

    OpenAIRE

    Martin Feldstein

    2013-01-01

    This paper examines the sources of current conflict within the EU and the EMU. The topics discussed include the recent ECB policy of bond buying (the OMT policy), the attempts to advance the "European Project" of stronger political union (the fiscal compact, the banking union, and the proposals for budget supervision). Contrary to the claims of the European leadership, the progress that has been made has been by individual countries and not by coordinated action. The special problems of Franc...

  18. Coordination strategies of crew management

    Science.gov (United States)

    Conley, Sharon; Cano, Yvonne; Bryant, Don

    1991-01-01

    An exploratory study that describes and contrasts two three-person flight crews performing in a B-727 simulator is presented. This study specifically attempts to delineate crew communication patterns accounting for measured differences in performance across routine and nonroutine flight patterns. The communication patterns in the two crews evaluated indicated different modes of coordination, i.e., standardization in the less effective crew and planning/mutual adjustment in the more effective crew.

  19. Monetary and Fiscal Policy Coordination

    OpenAIRE

    Hanif, Muhammad N.; Arby, Muhammad Farooq

    2003-01-01

    Macroeconomic policies are meant to achieve non-inflationary, stable growth. There are two major groups of policy instruments to achieve the purpose; one is related to monetary conditions and the other to fiscal conditions. Monetary instruments are employed by the central bank and fiscal instruments are employed by ministry of finance. The objectives and implications of policy measures taken by the two institutions often conflict with each other and thus call for policy coordination for effec...

  20. Inorganic, coordination and organometallic compounds

    International Nuclear Information System (INIS)

    Jursik, F.

    1978-01-01

    Separation of cations and anions of inorganic, coordination and metalloorganic compounds by the method of liquid column chromatography is considered. Common scheme of multicomponent cation mixture is suggesteed. Separation conditions, adsrbents, eluents, pH value solution concenstration, elution rate are also suggested. Separation of rare earth elements Cs, Be, Cd, Te, Th, U, Mo, Re, V, Ru, Zr, In compounds is considered as an example of liquid column chromatography application. Data on column chromatography application are summarized in a table

  1. Porphyrin coordination polymer nanospheres and nanorods

    Science.gov (United States)

    Wang, Zhongchun; Shelnutt, John A.; Medforth, Craig J.

    2012-12-04

    A porphyrin coordination polymer nanostructure comprising a network of pyridyl porphyrin molecules and coordinating metal ions coordinatively bound through the pyridyl groups. In some embodiments, the porphyrins are metalloporphyrins. A variety of nanostructures are formed by the network polymer, including nanospheres, polygonal nanostructures, nanorods, and nanofibers, depending on a variety of factors including coordination metal ion, porphyrin type, metal of the metalloporphyrin, and degree of agitation during nanostructure formation. Reduction of coordinating metal ions may be used to form metal nanoparticles on the coordination polymer nanostructure.

  2. Rare earth niobate coordination polymers

    Science.gov (United States)

    Muniz, Collin N.; Patel, Hiral; Fast, Dylan B.; Rohwer, Lauren E. S.; Reinheimer, Eric W.; Dolgos, Michelle; Graham, Matt W.; Nyman, May

    2018-03-01

    Rare-earth (RE) coordination polymers are infinitely tailorable to yield luminescent materials for various applications. Here we described the synthesis of a heterometallic rare-earth coordination compound ((CH3)2SO)3(RE)NbO(C2O4)3((CH3)2SO) = dimethylsulfoxide, DMSO, (C2O2= oxalate), (RE=La, Ce, Pr, Nd, Sm, Eu, Gd, Tb). The structure was obtained from single crystal X-ray diffraction of the La analogue. The Nb˭O and DMSO terminal-bonding character guides assembly of an open framework structure with noncentrosymmetric RE-coordination geometry, and large spacing between the RE centers. A second structure was observed by PXRD for the smaller rare earths (Dy, Ho, Er, Yb); this structure has not yet been determined. The materials were further characterized using FTIR, and photoluminescence measurements. Characteristic excitation and emission transitions were observed for RE = Nd, Sm, Eu, and Tb. Quantum yield (QY) measurements were performed by exciting Eu and Tb analoges at 394 nm (QY 66%) and 464 nm (QY 71%) for Eu; and 370 nm (QY=40%) for Tb. We attribute the high QY and bright luminescence to two main structure-function properties of the system; namely the absence of water in the structure, and absence of concentration quenching.

  3. Laser fluorescence spectroscopy by two-photon excitation for detection of hydrogen atoms in a periphery region of high temperature plasmas

    International Nuclear Information System (INIS)

    Kim, Hee-Je; Kajiwara, Toshinori; Motoyama, Sumio; Muraoka, Katsunori; Akazaki, Masanori; Okada, Tatsuo; Maeda, Mitsuo

    1989-01-01

    For measurements of atomic hydrogen density in the periphery region of high temperature plasmas, laser fluorescence spectroscopy (LFS) by two-photon excitation (1s-3s, 3d) was developed. Based upon the theoretical estimates for laser source requirements, which indicated the laser energy and spectral width to be more than 10 mJ (assuming the pulse duration of 10 ns) and several tens of picometers around the wavelength of 205.1 nm, respectively, the first Stokes generation in deuterium gas of ArF laser output was adopted and shown to have the necessary performance. Through the LFS experiment employing the laser source, the minimum detectable limit of atomic hydrogen, normalized by a laser power and an observing solid angle, was demonstrated to be 1 x 10 14 [m -3 · MW · sr], which is usually sufficient for the above purpose, and the accuracy of the density determination was shown to be within a factor 2. (author)

  4. The Transfer of Core-Based Hazardous Production Processes to the Export Processing Zones of the Periphery: The Maquiladora Centers of Northern Mexico

    Directory of Open Access Journals (Sweden)

    R. Scott Frey

    2015-08-01

    Full Text Available Transnational corporations appropriate 'carrying capacity" for the core by transferring the core's hazardous products, production processes, and wastes to the peripheral countries of the world-system. An increasingly important form of this reproduction process is the transfer of core-based hazardous industries to export processing zones (EPZs locatedin a number of peripheral countries in Africa, Asia, and Latin America and the Caribbean. A specific case is examined in this paper: the transfer of hazardous industries to the maquiladora centers located on the Mexican side of the Mexico-U.S. border. Maquiladoras provide an excellent case for examining what is known about the causes, adverse consequences, and political responses associated with the transfer of core-based hazardous production processes to the EPZs of the periphery.

  5. Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain.

    Science.gov (United States)

    Giorgini, Flaviano; Huang, Shao-Yi; Sathyasaikumar, Korrapati V; Notarangelo, Francesca M; Thomas, Marian A R; Tararina, Margarita; Wu, Hui-Qiu; Schwarcz, Robert; Muchowski, Paul J

    2013-12-20

    Kynurenine 3-monooxygenase (KMO), a pivotal enzyme in the kynurenine pathway (KP) of tryptophan degradation, has been suggested to play a major role in physiological and pathological events involving bioactive KP metabolites. To explore this role in greater detail, we generated mice with a targeted genetic disruption of Kmo and present here the first biochemical and neurochemical characterization of these mutant animals. Kmo(-/-) mice lacked KMO activity but showed no obvious abnormalities in the activity of four additional KP enzymes tested. As expected, Kmo(-/-) mice showed substantial reductions in the levels of its enzymatic product, 3-hydroxykynurenine, in liver, brain, and plasma. Compared with wild-type animals, the levels of the downstream metabolite quinolinic acid were also greatly decreased in liver and plasma of the mutant mice but surprisingly were only slightly reduced (by ∼20%) in the brain. The levels of three other KP metabolites: kynurenine, kynurenic acid, and anthranilic acid, were substantially, but differentially, elevated in the liver, brain, and plasma of Kmo(-/-) mice, whereas the liver and brain content of the major end product of the enzymatic cascade, NAD(+), did not differ between Kmo(-/-) and wild-type animals. When assessed by in vivo microdialysis, extracellular kynurenic acid levels were found to be significantly elevated in the brains of Kmo(-/-) mice. Taken together, these results provide further evidence that KMO plays a key regulatory role in the KP and indicate that Kmo(-/-) mice will be useful for studying tissue-specific functions of individual KP metabolites in health and disease.

  6. Ties between Center and Periphery in the Scientific World-System: Accumulation of Rewards, Dominance and Self-Reliance in the Center

    Directory of Open Access Journals (Sweden)

    Thomas Schott

    2015-08-01

    Full Text Available This study accounts for the organization of scientific research in networks of socio-intellectual tices that bind scientists into a community cultivating the scientific tradition. During the twentieth century the scientific community has become incrcasingly global both in the sense that its membership has spread world-widely and in the sense that its long-distance ties have intensified. The globalization of the community and its ties has been promoted by widely institutionalized arrangements, especially through the world's adoption of and belief in several scientific tenets: the universal validity of scientific knowledge, the ownership principle that knowledge should be the common property of humankind, and the political principle of granting autonomy to scientists for forming ties. The community and its network of ties form a hierarchy with centers attracting ties from peripheries. During the twentieth century the main center has shifted from Western Europe to North America while Eastern Europe has become less central, East Asia has become a bit central, and other regions have remained peripheral. A center attracts students from around the world for education, attracts scientists for conferences and visits, attracts deference from scientists throughout the world, exerts pervasive influence, is widely emulated, and is a desired source of recognition . In the global networks of ties, specifically of deference, influence, emulation and desire for recognition, there is an accumulation in the center of ties, both from within the center as an enhanced self-reliance and from the periphery as an enhanced centrality, exceeding the research performance at the center.

  7. Diethylstilbestrol alters positive and negative selection of T cells in the thymus and modulates T-cell repertoire in the periphery

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Nicole [Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 (United States); Nagarkatti, Mitzi [Department of Microbiology and Immunology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA 23298 (United States); Nagarkatti, Prakash S [Department of Pharmacology and Toxicology, PO Box 980613, Virginia Commonwealth University Medical Center, Richmond, VA 23298-0613 (United States)

    2006-04-15

    Prenatal exposure to diethylstilbestrol (DES) is known to cause altered immune functions and increased susceptibility to autoimmune disease in humans. In the current study, we investigated the effects of DES on T-cell differentiation in the thymus using the HY-TCR transgenic (Tg) mouse model in which the female mice exhibit positive selection of T cells bearing the Tg TCR, while the male mice show negative selection of such T cells. In female HY-TCR-Tg mice, exposure to DES showed more pronounced decrease in thymic cellularity when compared to male mice. Additionally, female mice also showed a significant decrease in the proportion of double-positive (DP) T cells in the thymus and HY-TCR-specific CD8{sup +} T cells in the periphery. Male mice exhibiting negative selection also showed decreased thymic cellularity following DES exposure. Moreover, the male mice showed increased proportion of double-negative (DN) T cells in the thymus and decreased proportion of CD8{sup +} T cells. The density of expression of HY-TCR on CD8{sup +} cells was increased following DES exposure in both females and males. Finally, the proliferative response of thymocytes to mitogens and peripheral lymph node T cells to male H-Y antigen was significantly altered in female and male mice following DES treatment. Taken together, these data suggest that DES alters T-cell differentiation in the thymus by interfering with positive and negative selection processes, which in turn modulates the T-cell repertoire in the periphery.

  8. Population size, center-periphery, and seed dispersers' effects on the genetic diversity and population structure of the Mediterranean relict shrub Cneorum tricoccon.

    Science.gov (United States)

    Lázaro-Nogal, Ana; Matesanz, Silvia; García-Fernández, Alfredo; Traveset, Anna; Valladares, Fernando

    2017-09-01

    The effect of population size on population genetic diversity and structure has rarely been studied jointly with other factors such as the position of a population within the species' distribution range or the presence of mutualistic partners influencing dispersal. Understanding these determining factors for genetic variation is critical for conservation of relict plants that are generally suffering from genetic deterioration. Working with 16 populations of the vulnerable relict shrub Cneorum tricoccon throughout the majority of its western Mediterranean distribution range, and using nine polymorphic microsatellite markers, we examined the effects of periphery (peripheral vs. central), population size (large vs. small), and seed disperser (introduced carnivores vs. endemic lizards) on the genetic diversity and population structure of the species. Contrasting genetic variation ( H E : 0.04-0.476) was found across populations. Peripheral populations showed lower genetic diversity, but this was dependent on population size. Large peripheral populations showed high levels of genetic diversity, whereas small central populations were less diverse. Significant isolation by distance was detected, indicating that the effect of long-distance gene flow is limited relative to that of genetic drift, probably due to high selfing rates ( F IS  = 0.155-0.887), restricted pollen flow, and ineffective seed dispersal. Bayesian clustering also supported the strong population differentiation and highly fragmented structure. Contrary to expectations, the type of disperser showed no significant effect on either population genetic diversity or structure. Our results challenge the idea of an effect of periphery per se that can be mainly explained by population size, drawing attention to the need of integrative approaches considering different determinants of genetic variation. Furthermore, the very low genetic diversity observed in several small populations and the strong among

  9. An event-related potential study on the interaction between lighting level and stimulus spatial location

    Directory of Open Access Journals (Sweden)

    Luis eCarretié

    2015-11-01

    Full Text Available Due to heterogeneous photoreceptor distribution, spatial location of stimulation is crucial to study visual brain activity in different light environments. This unexplored issue was studied through occipital event-related potentials (ERPs recorded from 40 participants in response to discrete visual stimuli presented at different locations and in two environmental light conditions, low mesopic (L, 0.03 lux and high mesopic (H, 6.5 lux, characterized by a differential photoreceptor activity balance: rod>cone and rodperiphery (above or below fixation or at the horizontal periphery (left or right. Analyses showed that occipital ERPs presented important L vs. H differences in the 100 to 450 millisecond window, which were significantly modulated by spatial location of stimulation: differences were greater in response to peripheral stimuli than to stimuli presented at fixation. Moreover, in the former case, significance of L vs. H differences was even stronger in response to stimuli presented at the horizontal than at the vertical periphery. These low vs. high mesopic differences may be explained by photoreceptor activation and their retinal distribution, and confirm that ERPs discriminate between rod- and cone-originated visual processing.

  10. Event dependent sampling of recurrent events

    DEFF Research Database (Denmark)

    Kvist, Tine Kajsa; Andersen, Per Kragh; Angst, Jules

    2010-01-01

    The effect of event-dependent sampling of processes consisting of recurrent events is investigated when analyzing whether the risk of recurrence increases with event count. We study the situation where processes are selected for study if an event occurs in a certain selection interval. Motivation...... retrospective and prospective disease course histories are used. We examine two methods to correct for the selection depending on which data are used in the analysis. In the first case, the conditional distribution of the process given the pre-selection history is determined. In the second case, an inverse...

  11. Multisites Coordination in Shared Multicast Trees

    National Research Council Canada - National Science Library

    Dommel, H-P; Garcia-Luna-Aceves, J. J

    1999-01-01

    .... The protocol supports Internet-wide coordination for large and highly interactive groupwork, relying on transmission of coordination directives between group members across a shared end-to-end multicast tree...

  12. International Coordination of Lunar Polar Volatiles Exploration

    Science.gov (United States)

    Gruener, J. E.; Suzuki, N. H.; Carpenter, J. D.

    2015-10-01

    The International Space Exploration Coordination Group (ISECG) has established a study team to coordinate the worldwide interest in lunar polar volatiles, and in particular water ice, in an effort to stimulate cooperation and collaboration.

  13. The Imperative for Improved Global Economic Coordination

    OpenAIRE

    Stiglitz, Joseph E.

    2009-01-01

    While global coordination is absolutely essential, success in achieving it may prove difficult because economic globalization has outpaced political globalization. If we are to succeed, we will have to manage coordination better than we have in the past.

  14. Dreams: a framework for distributed synchronous coordination

    NARCIS (Netherlands)

    Proença, J.; Clarke, D.; Vink, de E.P.; Arbab, F.

    2012-01-01

    Synchronous coordination systems, such as Reo, exchange data via indivisible actions, while distributed systems are typically asynchronous and assume that messages can be delayed or get lost. To combine these seemingly contradictory notions, we introduce the Dreams framework. Coordination patterns

  15. Reusable coordinator modules for massively concurrent applications

    NARCIS (Netherlands)

    F. Arbab (Farhad); C.L. Blom (Kees); F.J. Burger (Freek); C.T.H. Everaars (Kees)

    1998-01-01

    htmlabstractIsolating computation and communication concerns into separate pure computation and pure coordination modules enhances modularity, understandability and reusability of parallel and/or distributed software. MANIFOLD is a pure coordination language that encourages this separation. We use

  16. Coordinator, Evaluation Unit | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Job Summary The Evaluation Unit Coordinator is expected to: ... with Centre policies and procedures and disseminates information to Unit staff on changes ... Coordinates the planning and organization of technical and administrative meetings ...

  17. Process Coordination & Policy Officer | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Such liaison aims to ensure that the operational aspects and requirements are taken into account. ... Business Process Coordination and Change Management ... plan and coordinating the update of the Division's work plan by all managers; ...

  18. 78 FR 68995 - Special Local Regulation; Southern California Annual Marine Events for the San Diego Captain of...

    Science.gov (United States)

    2013-11-18

    ... notification of this enforcement period via the Local Notice to Mariners and local advertising by the event... Broadcast Notice to Mariners or other communications coordinated by the event sponsor to grant general...

  19. 78 FR 66844 - Special Local Regulation; Southern California Annual Marine Events for the San Diego Captain of...

    Science.gov (United States)

    2013-11-07

    ... notification of this enforcement period via the Local Notice to Mariners and local advertising by the event... Broadcast Notice to Mariners or other communications coordinated by the event sponsor to grant general...

  20. Modeling Coordination Problems in a Music Ensemble

    DEFF Research Database (Denmark)

    Frimodt-Møller, Søren R.

    2008-01-01

    This paper considers in general terms, how musicians are able to coordinate through rational choices in a situation of (temporary) doubt in an ensemble performance. A fictitious example involving a 5-bar development in an unknown piece of music is analyzed in terms of epistemic logic, more...... to coordinate. Such coordination can be described in terms of Michael Bacharach's theory of variable frames as an aid to solve game theoretic coordination problems....

  1. Parenting Coordinators' Practices Recommendations: A Qualitative Study

    OpenAIRE

    Hirsch, Barbara Phyllis

    2016-01-01

    This qualitative study used a phenomenological approach to understand the experiences of seven parenting coordinators in using parenting coordination practices that they have found to be effective and would recommend to other parenting coordinators to achieve the following goals: educating parents, increasing the quality of parenting and co-parenting, managing conflict, and involving children and other family members in the process of parenting coordination. Data were collected with semi-str...

  2. A Dynamic Coordination Mechanism Using Adjustable Autonomy

    NARCIS (Netherlands)

    Neef, R.M.; Vecht, B. van der; Dignum, F.; Meyer, J.J.C.

    2008-01-01

    Agents in an organization need to coordinate their actions in order to reach the organizational goals. This research describes the relation between types of coordination and the autonomy of actors. In an experimental setting we show that there is not one best way to coordinate in all situations. The

  3. A Dynamic Coordination Mechanism Using Adjustable Autonomy

    NARCIS (Netherlands)

    Vecht, B. van der; Dignum, F.; Meyer, J.J.C.; Neef, R.M.

    2007-01-01

    Agents in an organization need to coordinate their actions in order to reach the organizational goals. This research describes the relation between types of coordination and the autonomy of actors. In an experimental setting we show that there is not one best way to coordinate in all situations. The

  4. 45 CFR 1310.23 - Coordinated transportation.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Coordinated transportation. 1310.23 Section 1310... START PROGRAM HEAD START TRANSPORTATION Special Requirements § 1310.23 Coordinated transportation. (a) Each agency providing transportation services must make reasonable efforts to coordinate transportation...

  5. The unified coordination language UnCL.

    NARCIS (Netherlands)

    F.S. de Boer (Frank); J.V. Guillen Scholten (Juan); J.F. Jacob (Joost)

    2005-01-01

    textabstractIn this paper we show how to use a (subset) of UML as an Unified Coordination Language (UnCL) that is based on a separation of concerns between coordination and computation. As such UnCL provides a general language for the coordination of, in particular, object-oriented applications. The

  6. A Note on the Dipole Coordinates

    OpenAIRE

    Kageyama, Akira; Sugiyama, Tooru; Watanabe, Kunihiko; Sato, Tetsuya

    2004-01-01

    A couple of orthogonal coordinates for dipole geometry are proposed for numerical simulations of plasma geophysics in the Earth's dipole magnetic field. These coordinates have proper metric profiles along field lines in contrast to the standard dipole coordinate system that is commonly used in analytical studies for dipole geometry.

  7. Optimization of strong and weak coordinates

    NARCIS (Netherlands)

    Swart, M.; Bickelhaupt, F.M.

    2006-01-01

    We present a new scheme for the geometry optimization of equilibrium and transition state structures that can be used for both strong and weak coordinates. We use a screening function that depends on atom-pair distances to differentiate strong coordinates from weak coordinates. This differentiation

  8. 47 CFR 27.57 - International coordination.

    Science.gov (United States)

    2010-10-01

    ... COMMUNICATIONS SERVICES Technical Standards § 27.57 International coordination. (a) WCS operations in the border areas shall be subject to coordination with those countries and provide protection to non-U.S... 47 Telecommunication 2 2010-10-01 2010-10-01 false International coordination. 27.57 Section 27.57...

  9. 40 CFR 109.6 - Coordination.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Coordination. 109.6 Section 109.6 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS CRITERIA FOR STATE, LOCAL AND REGIONAL OIL REMOVAL CONTINGENCY PLANS § 109.6 Coordination. For the purposes of coordination...

  10. 49 CFR 214.325 - Train coordination.

    Science.gov (United States)

    2010-10-01

    ..., DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.325 Train coordination. Working limits established by a roadway worker through the use of train coordination shall comply with the... 49 Transportation 4 2010-10-01 2010-10-01 false Train coordination. 214.325 Section 214.325...

  11. Computation at a coordinate singularity

    Science.gov (United States)

    Prusa, Joseph M.

    2018-05-01

    Coordinate singularities are sometimes encountered in computational problems. An important example involves global atmospheric models used for climate and weather prediction. Classical spherical coordinates can be used to parameterize the manifold - that is, generate a grid for the computational spherical shell domain. This particular parameterization offers significant benefits such as orthogonality and exact representation of curvature and connection (Christoffel) coefficients. But it also exhibits two polar singularities and at or near these points typical continuity/integral constraints on dependent fields and their derivatives are generally inadequate and lead to poor model performance and erroneous results. Other parameterizations have been developed that eliminate polar singularities, but problems of weaker singularities and enhanced grid noise compared to spherical coordinates (away from the poles) persist. In this study reparameterization invariance of geometric objects (scalars, vectors and the forms generated by their covariant derivatives) is utilized to generate asymptotic forms for dependent fields of interest valid in the neighborhood of a pole. The central concept is that such objects cannot be altered by the metric structure of a parameterization. The new boundary conditions enforce symmetries that are required for transformations of geometric objects. They are implemented in an implicit polar filter of a structured grid, nonhydrostatic global atmospheric model that is simulating idealized Held-Suarez flows. A series of test simulations using different configurations of the asymptotic boundary conditions are made, along with control simulations that use the default model numerics with no absorber, at three different grid sizes. Typically the test simulations are ∼ 20% faster in wall clock time than the control-resulting from a decrease in noise at the poles in all cases. In the control simulations adverse numerical effects from the polar

  12. Application coordination in pervasive systems

    CERN Document Server

    Majuntke, Verena Elisabeth

    2013-01-01

    Pervasive applications are designed to support users in their daily life. For this purpose, applications interact with their environment, i.e. their context. They are able to adapt themselves to context changes or to explicitly change the context via actuators. If multiple applications are executed in the same context, interferences are likely to occur. To manage interferences, a coordination framework is presented in this thesis. Interferences are detected using a context model and information about applications' interaction with the context. The resolution of interference is achieved through

  13. Coordination compounds in nuclear medicine

    International Nuclear Information System (INIS)

    Jurisson, S.; Berning, D.; Wei Jia; Dangshe Ma

    1993-01-01

    Radiopharmaceuticals, drugs containing a radionuclide, are used routinely in nuclear medicine departments for the diagnosis of disease and are under investigation for use in the treatment of disease. Nuclear medicine takes advantage of both the nuclear properties of the radionuclide and the pharmacological properties of the radiopharmaceutical. Herein lies the real strength of nuclear medicine, the ability to monitor biochemical and physiological functions in vivo. This review discusses the coordination chemistry that forms the basis for nuclear medicine applications of the FDA-approved radiopharmaceuticals that are in clinical use, and of the most promising diagnostic and therapeutic radiopharmaceuticals that are in various stages of development. 232 refs

  14. Coordinated hybrid automatic repeat request

    KAUST Repository

    Makki, Behrooz

    2014-11-01

    We develop a coordinated hybrid automatic repeat request (HARQ) approach. With the proposed scheme, if a user message is correctly decoded in the first HARQ rounds, its spectrum is allocated to other users, to improve the network outage probability and the users\\' fairness. The results, which are obtained for single- and multiple-antenna setups, demonstrate the efficiency of the proposed approach in different conditions. For instance, with a maximum of M retransmissions and single transmit/receive antennas, the diversity gain of a user increases from M to (J+1)(M-1)+1 where J is the number of users helping that user.

  15. Event-by-event jet quenching

    Energy Technology Data Exchange (ETDEWEB)

    Fries, R.J.; Rodriguez, R.; Ramirez, E.

    2010-08-14

    High momentum jets and hadrons can be used as probes for the quark gluon plasma (QGP) formed in nuclear collisions at high energies. We investigate the influence of fluctuations in the fireball on jet quenching observables by comparing propagation of light quarks and gluons through averaged, smooth QGP fireballs with event-by-event jet quenching using realistic inhomogeneous fireballs. We find that the transverse momentum and impact parameter dependence of the nuclear modification factor R{sub AA} can be fit well in an event-by-event quenching scenario within experimental errors. However the transport coefficient {cflx q} extracted from fits to the measured nuclear modification factor R{sub AA} in averaged fireballs underestimates the value from event-by-event calculations by up to 50%. On the other hand, after adjusting {cflx q} to fit R{sub AA} in the event-by-event analysis we find residual deviations in the azimuthal asymmetry v{sub 2} and in two-particle correlations, that provide a possible faint signature for a spatial tomography of the fireball. We discuss a correlation function that is a measure for spatial inhomogeneities in a collision and can be constrained from data.

  16. Event-by-event jet quenching

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez, R. [Cyclotron Institute and Physics Department, Texas A and M University, College Station, TX 77843 (United States); Fries, R.J., E-mail: rjfries@comp.tamu.ed [Cyclotron Institute and Physics Department, Texas A and M University, College Station, TX 77843 (United States); RIKEN/BNL Research Center, Brookhaven National Laboratory, Upton, NY 11973 (United States); Ramirez, E. [Physics Department, University of Texas El Paso, El Paso, TX 79968 (United States)

    2010-09-27

    High momentum jets and hadrons can be used as probes for the quark gluon plasma (QGP) formed in nuclear collisions at high energies. We investigate the influence of fluctuations in the fireball on jet quenching observables by comparing propagation of light quarks and gluons through averaged, smooth QGP fireballs with event-by-event jet quenching using realistic inhomogeneous fireballs. We find that the transverse momentum and impact parameter dependence of the nuclear modification factor R{sub AA} can be fit well in an event-by-event quenching scenario within experimental errors. However the transport coefficient q extracted from fits to the measured nuclear modification factor R{sub AA} in averaged fireballs underestimates the value from event-by-event calculations by up to 50%. On the other hand, after adjusting q to fit R{sub AA} in the event-by-event analysis we find residual deviations in the azimuthal asymmetry v{sub 2} and in two-particle correlations, that provide a possible faint signature for a spatial tomography of the fireball. We discuss a correlation function that is a measure for spatial inhomogeneities in a collision and can be constrained from data.

  17. Event-by-event fluctuations at SPS

    CERN Document Server

    Appelshauser, Harald; Adamova, D.; Agakichiev, G.; Belaga, V.; Braun-Munzinger, P.; Castillo, A.; Cherlin, A.; Damjanovic, S.; Dietel, T.; Dietrich, L.; Drees, A.; Esumi, S.I.; Filimonov, K.; Fomenko, K.; Fraenkel, Z.; Garabatos, C.; Glassel, P.; Hering, G.; Holeczek, J.; Kushpil, V.; Lenkeit, B.; Ludolphs, W.; Maas, A.; Marn, A.; Milosevic, J.; Milov, A.; Miskowiec, D.; Panebrattsev, Yu.; Petchenova, O.; Petracek, V.; Pfeiffer, A.; Rak, J.; Ravinovich, I.; Rehak, P.; Schmitz, W.; Schukraft, J.; Sedykh, S.; Shimansky, S.; Slvova, J.; Stachel, J.; Sumbera, M.; Tilsner, H.; Tserruya, Itzhak; Wessels, J.P.; Wienold, T.; Windelband, B.; Wurm, J.P.; Xie, W.; Yurevich, S.; Yurevich, V.; Appelshauser, Harald; Sako, Hiro

    2005-01-01

    Results on event-by-event fluctuations of the mean transverse momentum and net charge in Pb-Au collisions, measured by the CERES Collaboration at CERN-SPS, are presented. We discuss the centrality and beam energy dependence and compare our data to cascade calculations.

  18. BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks.

    Science.gov (United States)

    Guardia, Carlos M; Farías, Ginny G; Jia, Rui; Pu, Jing; Bonifacino, Juan S

    2016-11-15

    The multiple functions of lysosomes are critically dependent on their ability to undergo bidirectional movement along microtubules between the center and the periphery of the cell. Centrifugal and centripetal movement of lysosomes is mediated by kinesin and dynein motors, respectively. We recently described a multi-subunit complex named BORC that recruits the small GTPase Arl8 to lysosomes to promote their kinesin-dependent movement toward the cell periphery. Here, we show that BORC and Arl8 function upstream of two structurally distinct kinesin types: kinesin-1 (KIF5B) and kinesin-3 (KIF1Bβ and KIF1A). Remarkably, KIF5B preferentially moves lysosomes on perinuclear tracks enriched in acetylated α-tubulin, whereas KIF1Bβ and KIF1A drive lysosome movement on more rectilinear, peripheral tracks enriched in tyrosinated α-tubulin. These findings establish BORC as a master regulator of lysosome positioning through coupling to different kinesins and microtubule tracks. Common regulation by BORC enables coordinate control of lysosome movement in different regions of the cell. Published by Elsevier Inc.

  19. The coordination of boundary tones and its interaction with prominence.

    Science.gov (United States)

    Katsika, Argyro; Krivokapić, Jelena; Mooshammer, Christine; Tiede, Mark; Goldstein, Louis

    2014-05-01

    This study investigates the coordination of boundary tones as a function of stress and pitch accent. Boundary tone coordination has not been experimentally investigated previously, and the effect of prominence on this coordination, and whether it is lexical (stress-driven) or phrasal (pitch accent-driven) in nature is unclear. We assess these issues using a variety of syntactic constructions to elicit different boundary tones in an Electromagnetic Articulography (EMA) study of Greek. The results indicate that the onset of boundary tones co-occurs with the articulatory target of the final vowel. This timing is further modified by stress, but not by pitch accent: boundary tones are initiated earlier in words with non-final stress than in words with final stress regardless of accentual status. Visual data inspection reveals that phrase-final words are followed by acoustic pauses during which specific articulatory postures occur. Additional analyses show that these postures reach their achievement point at a stable temporal distance from boundary tone onsets regardless of stress position. Based on these results and parallel findings on boundary lengthening reported elsewhere, a novel approach to prosody is proposed within the context of Articulatory Phonology: rather than seeing prosodic (lexical and phrasal) events as independent entities, a set of coordination relations between them is suggested. The implications of this account for prosodic architecture are discussed.

  20. Unpacking Coordination Benefits in Supply Networks

    DEFF Research Database (Denmark)

    Petrick, Irene J.; Maitland, Carleen; Pogrebnyakov, Nicolai

    2016-01-01

    This paper examines how coordination among firms in supply networks generates benefits in the short and long terms for firms. It focuses on information technology (IT) and process improvement coordination. Analysis was performed on quantitative and qualitative data from a sample of SMEs in plastics...... manufacturing in Pennsylvania. Results indicate that coordination on both IT and process improvement leads to short- and long-term benefits. These relationships were mediated by the adoption of innovations (when coordinating on IT) and access to new capabilities (in process improvement coordination......). These results extend the understanding of how participation in supply networks benefits individual firms....

  1. Internationally coordinated glacier monitoring: strategy and datasets

    Science.gov (United States)

    Hoelzle, Martin; Armstrong, Richard; Fetterer, Florence; Gärtner-Roer, Isabelle; Haeberli, Wilfried; Kääb, Andreas; Kargel, Jeff; Nussbaumer, Samuel; Paul, Frank; Raup, Bruce; Zemp, Michael

    2014-05-01

    Internationally coordinated monitoring of long-term glacier changes provide key indicator data about global climate change and began in the year 1894 as an internationally coordinated effort to establish standardized observations. Today, world-wide monitoring of glaciers and ice caps is embedded within the Global Climate Observing System (GCOS) in support of the United Nations Framework Convention on Climate Change (UNFCCC) as an important Essential Climate Variable (ECV). The Global Terrestrial Network for Glaciers (GTN-G) was established in 1999 with the task of coordinating measurements and to ensure the continuous development and adaptation of the international strategies to the long-term needs of users in science and policy. The basic monitoring principles must be relevant, feasible, comprehensive and understandable to a wider scientific community as well as to policy makers and the general public. Data access has to be free and unrestricted, the quality of the standardized and calibrated data must be high and a combination of detailed process studies at selected field sites with global coverage by satellite remote sensing is envisaged. Recently a GTN-G Steering Committee was established to guide and advise the operational bodies responsible for the international glacier monitoring, which are the World Glacier Monitoring Service (WGMS), the US National Snow and Ice Data Center (NSIDC), and the Global Land Ice Measurements from Space (GLIMS) initiative. Several online databases containing a wealth of diverse data types having different levels of detail and global coverage provide fast access to continuously updated information on glacier fluctuation and inventory data. For world-wide inventories, data are now available through (a) the World Glacier Inventory containing tabular information of about 130,000 glaciers covering an area of around 240,000 km2, (b) the GLIMS-database containing digital outlines of around 118,000 glaciers with different time stamps and

  2. Situational awareness of a coordinated cyber attack

    Science.gov (United States)

    Sudit, Moises; Stotz, Adam; Holender, Michael

    2005-03-01

    As technology continues to advance, services and capabilities become computerized, and an ever increasing amount of business is conducted electronically the threat of cyber attacks gets compounded by the complexity of such attacks and the criticality of the information which must be secured. A new age of virtual warfare has dawned in which seconds can differentiate between the protection of vital information and/or services and a malicious attacker attaining their goal. In this paper we present a novel approach in the real-time detection of multistage coordinated cyber attacks and the promising initial testing results we have obtained. We introduce INFERD (INformation Fusion Engine for Real-time Decision-making), an adaptable information fusion engine which performs fusion at levels zero, one, and two to provide real-time situational assessment and its application to the cyber domain in the ECCARS (Event Correlation for Cyber Attack Recognition System) system. The advantages to our approach are fourfold: (1) The complexity of the attacks which we consider, (2) the level of abstraction in which the analyst interacts with the attack scenarios, (3) the speed at which the information fusion is presented and performed, and (4) our disregard for ad-hoc rules or a priori parameters.

  3. Distributed Sensor Coordination for Advanced Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Tumer, Kagan [Oregon State Univ., Corvallis, OR (United States)

    2013-07-31

    towards “what to observe” rather than “how to observe” in large sensor networks, allowing the agents to actively determine both the structure of the network and the relevance of the information they are seeking to collect. In addition to providing an implicit coordination mechanism, this approach allows the system to be reconfigured in response to changing needs (e.g., sudden external events requiring new responses) or changing sensor network characteristics (e.g., sudden changes to plant condition). Outcome Summary: All milestones associated with this project have been completed. In particular, private sensor objective functions were developed which are aligned with the global objective function, sensor effectiveness has been improved by using “sensor teams,” system efficiency has been improved by 30% using difference evaluation functions, we have demonstrated system reconfigurability for 20% changes in system conditions, we have demonstrated extreme scalability of our proposed algorithm, we have demonstrated that sensor networks can overcome disruptions of up to 20% in network conditions, and have demonstrated system reconfigurability to 20% changes in system conditions in hardware-based simulations. This final report summarizes how each of these milestones was achieved, and gives insight into future research possibilities past the work which has been completed. The following publications support these milestones [6, 8, 9, 10, 16, 18, 19].

  4. Coordinated research projects (CRP). Coordinated research project (CRP)

    International Nuclear Information System (INIS)

    Takagi, Hidekazu; Koike, Fumihiro; Nakamura, Nobuyuki

    2013-01-01

    In the present paper, the contribution of Japanese scientists in coordinated research projects on thermonuclear fusion. Representative subjects taken in seven projects are the precise computation of theoretical data on electron-molecule collisions in the peripheral plasma, the computation of spectroscopic data of multi-charged tungsten ions, the spectroscopic measurement of multi-charged tungsten ions using an ion trap device, the development of collisional-radiative model for plasmas including hydrogen and helium, the computational and theoretical studies on the behavior of tungsten and beryllium in the plasma-wall interaction, the study on the property of dusts generated in fusion devices. These subjects are those of most important issues in ITER. (author)

  5. Episodes, events, and models

    Directory of Open Access Journals (Sweden)

    Sangeet eKhemlani

    2015-10-01

    Full Text Available We describe a novel computational theory of how individuals segment perceptual information into representations of events. The theory is inspired by recent findings in the cognitive science and cognitive neuroscience of event segmentation. In line with recent theories, it holds that online event segmentation is automatic, and that event segmentation yields mental simulations of events. But it posits two novel principles as well: first, discrete episodic markers track perceptual and conceptual changes, and can be retrieved to construct event models. Second, the process of retrieving and reconstructing those episodic markers is constrained and prioritized. We describe a computational implementation of the theory, as well as a robotic extension of the theory that demonstrates the processes of online event segmentation and event model construction. The theory is the first unified computational account of event segmentation and temporal inference. We conclude by demonstrating now neuroimaging data can constrain and inspire the construction of process-level theories of human reasoning.

  6. FY 1974 report on the results of the Sunshine Project. Comprehensive study of hydrogen use subsystem and study on the periphery technology (Study on the periphery technology of hydrogen); 1974 nendo suiso riyo subsystem no sogoteki kento to shuhen gijutsu ni kansuru kenkyu seika hokokusho. Suiso no shuhen gijutsu ni kansuru kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1975-05-01

    This is aimed at making an investigational study on the periphery technology and sprouting technology of the hydrogen energy system. In Volume 1, 'Technology of hydrogen production,' as to the hydrogen production, the paper summed up the expected technical subjects on the electrolysis method and thermochemical method. The paper further included the survey of the direct pyrolysis method and the hydrogen production method using solar energy. Concerning the latter, in Volume 2, the light electrode reaction was theoretically developed, and samples of various hybrid methods were concretely studied. In relation to subjects on hydrogen and materials, in Volume 3, the results were described of the investigation into the hydrogen behavior in metal which is the most basic field of the subjects. About the storage method which is important as periphery technology, the study was made of the methods which can be expected but liquefied hydrogen and metal hydride which are now under research and development. In the last volume, as a part of the work to review the hydrogen energy system from a wider viewpoint, the basic study was additionally made in comparison with the system using coal. (NEDO)

  7. FY 1974 report on the results of the Sunshine Project. Comprehensive study of hydrogen use subsystem and study on the periphery technology (Study on the periphery technology of hydrogen); 1974 nendo suiso riyo subsystem no sogoteki kento to shuhen gijutsu ni kansuru kenkyu seika hokokusho. Suiso no shuhen gijutsu ni kansuru kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1975-05-01

    This is aimed at making an investigational study on the periphery technology and sprouting technology of the hydrogen energy system. In Volume 1, 'Technology of hydrogen production,' as to the hydrogen production, the paper summed up the expected technical subjects on the electrolysis method and thermochemical method. The paper further included the survey of the direct pyrolysis method and the hydrogen production method using solar energy. Concerning the latter, in Volume 2, the light electrode reaction was theoretically developed, and samples of various hybrid methods were concretely studied. In relation to subjects on hydrogen and materials, in Volume 3, the results were described of the investigation into the hydrogen behavior in metal which is the most basic field of the subjects. About the storage method which is important as periphery technology, the study was made of the methods which can be expected but liquefied hydrogen and metal hydride which are now under research and development. In the last volume, as a part of the work to review the hydrogen energy system from a wider viewpoint, the basic study was additionally made in comparison with the system using coal. (NEDO)

  8. Voice loops as coordination aids in space shuttle mission control.

    Science.gov (United States)

    Patterson, E S; Watts-Perotti, J; Woods, D D

    1999-01-01

    Voice loops, an auditory groupware technology, are essential coordination support tools for experienced practitioners in domains such as air traffic management, aircraft carrier operations and space shuttle mission control. They support synchronous communication on multiple channels among groups of people who are spatially distributed. In this paper, we suggest reasons for why the voice loop system is a successful medium for supporting coordination in space shuttle mission control based on over 130 hours of direct observation. Voice loops allow practitioners to listen in on relevant communications without disrupting their own activities or the activities of others. In addition, the voice loop system is structured around the mission control organization, and therefore directly supports the demands of the domain. By understanding how voice loops meet the particular demands of the mission control environment, insight can be gained for the design of groupware tools to support cooperative activity in other event-driven domains.

  9. Dynamics of Charged Events

    International Nuclear Information System (INIS)

    Bachas, Constantin; Bunster, Claudio; Henneaux, Marc

    2009-01-01

    In three spacetime dimensions the world volume of a magnetic source is a single point, an event. We make the event dynamical by regarding it as the imprint of a flux-carrying particle impinging from an extra dimension. This can be generalized to higher spacetime dimensions and to extended events. We exhibit universal observable consequences of the existence of events and argue that events are as important as particles or branes. We explain how events arise on the world volume of membranes in M theory, and in a Josephson junction in superconductivity.

  10. The global event system

    International Nuclear Information System (INIS)

    Winans, J.

    1994-01-01

    The support for the global event system has been designed to allow an application developer to control the APS event generator and receiver boards. This is done by the use of four new record types. These records are customized and are only supported by the device support modules for the APS event generator and receiver boards. The use of the global event system and its associated records should not be confused with the vanilla EPICS events and the associated event records. They are very different

  11. Extreme weather events and infectious disease outbreaks.

    Science.gov (United States)

    McMichael, Anthony J

    2015-01-01

    Human-driven climatic changes will fundamentally influence patterns of human health, including infectious disease clusters and epidemics following extreme weather events. Extreme weather events are projected to increase further with the advance of human-driven climate change. Both recent and historical experiences indicate that infectious disease outbreaks very often follow extreme weather events, as microbes, vectors and reservoir animal hosts exploit the disrupted social and environmental conditions of extreme weather events. This review article examines infectious disease risks associated with extreme weather events; it draws on recent experiences including Hurricane Katrina in 2005 and the 2010 Pakistan mega-floods, and historical examples from previous centuries of epidemics and 'pestilence' associated with extreme weather disasters and climatic changes. A fuller understanding of climatic change, the precursors and triggers of extreme weather events and health consequences is needed in order to anticipate and respond to the infectious disease risks associated with human-driven climate change. Post-event risks to human health can be constrained, nonetheless, by reducing background rates of persistent infection, preparatory action such as coordinated disease surveillance and vaccination coverage, and strengthened disaster response. In the face of changing climate and weather conditions, it is critically important to think in ecological terms about the determinants of health, disease and death in human populations.

  12. RoboCup European Championship: Report of the Amsterdam 2000 event

    NARCIS (Netherlands)

    Groen, F.; van der Hoek, W.; Jonker, P.; Krose, B.; Spoelder, H.J.W.; Stramigioli, S.

    2001-01-01

    The local organizers of the RoboCup European Championship presents a brief, informal overview of this event with the aim to support organizers of future RoboCup events in the organization and coordination of such a rather complex tournament. The objective was to organize a low cost scientific event

  13. Marketing Career Speed Networking: A Classroom Event to Foster Career Awareness

    Science.gov (United States)

    Buff, Cheryl L.; O'Connor, Suzanne

    2012-01-01

    This paper describes the design, implementation, and evaluation of a marketing career speed networking event held during class time in two sections of the consumer behavior class. The event was coordinated through a partnering effort with marketing faculty and the college's Career Center. A total of 57 students participated in the event, providing…

  14. Accumulation and foreign trade from a center-periphery perspective Acumulación y comercio exterior desde una perspectiva centro-periferia

    Directory of Open Access Journals (Sweden)

    García José Guillermo

    1998-06-01

    Full Text Available The theories which have attempted to explain the insertion of the countries of the periphery in the international division of labor haven't been able to explain in a satisfactory way the economic foundations and mechanisms of foreign trade in that contexto To understand the logic of the mechanism of peripheral insertion, the function served by foreign
    trade in the capital accumulation process must be analyzed. By going back to this problem in the classical analysis, some pieces of a new puzzle can be found. Smith's theory of the extension of the market, the structural heterogeneity of capitalism expressed in the differentiation of national price systems and profit rates according to Ricardo, and the foundations of the forms of mercantile and industrial accumulation in Marx are the new elements. The profit rate improves the conditions of accumulation when it exploits the differences in the national price systems. In the process of accumulation, the mechanisms of industrial accumulation operate in the interior, and they are strengthened by the
    mechanisms of mercantile accumulation which operate in external trade. As a consequence, the extension of the market outward to the periphery is only viable to the extent that this zone offers compensations which improve the condi tions determining the rates of profi t and accumulation
    in the center.Las teorías que han intentado explicar en forma satisfactoria los fundamentos y los mecanismos económicos del comercio exterior en ese contexto. Para entender la lógica del mecanismos de inserción periférica, es necesario analizar la funci´pon que cumple el comercio exterior en el proceso de acumulación de capital. Retomando está problemática en el análisis clásico, se pueden sacara las piezas del nuevo romprecabezas. La teroría de la extensión de mercados de Smith, la heterogenidad estructural del capitalismo expresada en la diferenciación de sistemas de precios nacionales y de tasas

  15. Event by event physics in ALICE

    CERN Document Server

    Christakoglou, Panos

    2009-01-01

    Fluctuations of thermodynamic quantities are fundamental for the study of the QGP phase transition. The ALICE experiment is well suited for precise event-by-event measurements of various quantities. In this article, we review the capabilities of ALICE to study the fluctuations of several key observables such as the net charge, the temperature, and the particle ratios. Among the observables related to correlations, we review the balance functions and the long range correlations.

  16. Coordinated control of electrical drives

    International Nuclear Information System (INIS)

    Keresztely, S.

    1983-01-01

    The control system developed for the fuel handling machine of nuclear power plants contains seven microcomputers. Redundant hardware and software structure ensures high reliability and availability. The sensors are doubled and each set is connected to its own microcomputer for evaluation of measurements. The control program, coordinating seven electrical drives, is run on two identical microcomputers, and has access to both sets of measurement results. Two control desks are provided. The seventh microcomputer generates the digital picture of the working site around the actual position and the picture is sent to color TV monitors at the control desks. System reliability: failure of any part of the system causes an error message and no action. System availability: for emergency purposes, one of every pair of the identical subsystems must be operational. In this emergency mode unconditional reliability is lost. (author)

  17. Coordination control of distributed systems

    CERN Document Server

    Villa, Tiziano

    2015-01-01

    This book describes how control of distributed systems can be advanced by an integration of control, communication, and computation. The global control objectives are met by judicious combinations of local and nonlocal observations taking advantage of various forms of communication exchanges between distributed controllers. Control architectures are considered according to  increasing degrees of cooperation of local controllers:  fully distributed or decentralized control,  control with communication between controllers,  coordination control, and multilevel control.  The book covers also topics bridging computer science, communication, and control, like communication for control of networks, average consensus for distributed systems, and modeling and verification of discrete and of hybrid systems. Examples and case studies are introduced in the first part of the text and developed throughout the book. They include: control of underwater vehicles, automated-guided vehicles on a container terminal, contro...

  18. Coordinating towards a Common Good

    Science.gov (United States)

    Santos, Francisco C.; Pacheco, Jorge M.

    2010-09-01

    Throughout their life, humans often engage in collective endeavors ranging from family related issues to global warming. In all cases, the tragedy of the commons threatens the possibility of reaching the optimal solution associated with global cooperation, a scenario predicted by theory and demonstrated by many experiments. Using the toolbox of evolutionary game theory, I will address two important aspects of evolutionary dynamics that have been neglected so far in the context of public goods games and evolution of cooperation. On one hand, the fact that often there is a threshold above which a public good is reached [1, 2]. On the other hand, the fact that individuals often participate in several games, related to the their social context and pattern of social ties, defined by a social network [3, 4, 5]. In the first case, the existence of a threshold above which collective action is materialized dictates a rich pattern of evolutionary dynamics where the direction of natural selection can be inverted compared to standard expectations. Scenarios of defector dominance, pure coordination or coexistence may arise simultaneously. Both finite and infinite population models are analyzed. In networked games, cooperation blooms whenever the act of contributing is more important than the effort contributed. In particular, the heterogeneous nature of social networks naturally induces a symmetry breaking of the dilemmas of cooperation, as contributions made by cooperators may become contingent on the social context in which the individual is embedded. This diversity in context provides an advantage to cooperators, which is particularly strong when both wealth and social ties follow a power-law distribution, providing clues on the self-organization of social communities. Finally, in both situations, it can be shown that individuals no longer play a defection dominance dilemma, but effectively engage in a general N-person coordination game. Even if locally defection may seem

  19. Conferences and Events

    International Development Research Centre (IDRC) Digital Library (Canada)

    André Lavoie

    2016-06-14

    Jun 14, 2016 ... Approved by the Management Executive Committee. - 1 - ... Event ‒ represents activities related to IDRC operations and may include both ... Events include business meetings; corporate, branch or divisional management.

  20. Initiating events frequency determination

    International Nuclear Information System (INIS)

    Simic, Z.; Mikulicic, V.; Vukovic, I.

    2004-01-01

    The paper describes work performed for the Nuclear Power Station (NPS). Work is related to the periodic initiating events frequency update for the Probabilistic Safety Assessment (PSA). Data for all relevant NPS initiating events (IE) were reviewed. The main focus was on events occurring during most recent operating history (i.e., last four years). The final IE frequencies were estimated by incorporating both NPS experience and nuclear industry experience. Each event was categorized according to NPS individual plant examination (IPE) initiating events grouping approach. For the majority of the IE groups, few, or no events have occurred at the NPS. For those IE groups with few or no NPS events, the final estimate was made by means of a Bayesian update with general nuclear industry values. Exceptions are rare loss-of-coolant-accidents (LOCA) events, where evaluation of engineering aspects is used in order to determine frequency.(author)

  1. Advertising Effectiveness In Events

    OpenAIRE

    Jain, Sushilkumar

    2012-01-01

    Confronted with decreasing effectiveness of the classic marketing communications, events have become an increasingly popular alternative for marketers. Events constitute one of the most exciting and fastest growing forms of leisure and business. With time, the decreasing effectiveness of classical marketing communications boosted the use of events for marketing and making brand awareness. Event marketing is seen as the unique opportunity to integrate the firm’s communication activities like p...

  2. Localization of Daucus carota NMCP1 to the nuclear periphery: the role of the N-terminal region and an NLS-linked sequence motif, RYNLRR, in the tail domain

    Directory of Open Access Journals (Sweden)

    Yuta eKimura

    2014-02-01

    Full Text Available Recent ultrastructural studies revealed that a structure similar to the vertebrate nuclear lamina exists in the nuclei of higher plants. However, plant genomes lack genes for lamins and intermediate-type filament proteins, and this suggests that plant-specific nuclear coiled-coil proteins make up the lamina-like structure in plants. NMCP1 is a protein, first identified in Daucus carota cells, that localizes exclusively to the nuclear periphery in interphase cells. It has a tripartite structure comprised of head, rod, and tail domains, and includes putative nuclear localization signal (NLS motifs. We identified the functional NLS of DcNMCP1 (carrot NMCP1 and determined the protein regions required for localizing to the nuclear periphery using EGFP-fused constructs transiently expressed in Apium graveolens epidermal cells. Transcription was driven under a CaMV35S promoter, and the genes were introduced into the epidermal cells by a DNA-coated microprojectile delivery system. Of the NLS motifs, KRRRK and RRHK in the tail domain were highly functional for nuclear localization. Addition of the N-terminal 141 amino acids from DcNMCP1 shifted the localization of a region including these NLSs from the entire nucleus to the nuclear periphery. Using this same construct, the replacement of amino acids in RRHK or its preceding sequence, YNL, with alanine residues abolished localization to the nuclear periphery, while replacement of KRRRK did not affect localization. The sequence R/Q/HYNLRR/H, including YNL and the first part of the sequence of RRHK, is evolutionarily conserved in a subclass of NMCP1 sequences from many plant species. These results show that NMCP1 localizes to the nuclear periphery by a combined action of a sequence composed of R/Q/HYNLRR/H, NLS, and the N-terminal region including the head and a portion of the rod domain, suggesting that more than one binding site is implicated in localization of NMCP1.

  3. A Mosque event

    DEFF Research Database (Denmark)

    Simonsen, Kirsten; Neergaard, Maja de; Koefoed, Lasse Martin

    2017-01-01

    and public imaginations attached to it. And they are connected to a specific event – the opening of the mosque. In the first part, a conceptual framework is presented bringing together literature on three notions: encounters, visibility and the event. Following this, the paper explores the opening event...

  4. On semirecurrent events

    International Nuclear Information System (INIS)

    Dvurechenskij, A.

    1984-01-01

    In some problems of the mathematical theory of particle counters, film or filmless measurements of track ionization in high energy physics,queueing theory, random walks, etc., the classes of emirecurrent and m-semirecurrent events, which generalize the recurrent events and the recurrent events with delay, appeared. In the paper their basic properties, and some relationships between them are shown

  5. Oil extraction in extreme remoteness. The organization of work and long-distance commuting in Russia's northern resource peripheries

    Energy Technology Data Exchange (ETDEWEB)

    Spies, M.

    2009-07-01

    The post-Soviet Russian North is characterised by very heterogeneous developments. In some northern peripheries, while the prominent resource industries create a substantial share of their revenues and generate local growth stimuli, other areas face post-Soviet decay. This thesis examines employee mobility in the form of long-distance commuting as an option for dealing with this challenge for regional and local development and analyses its offerings to stakeholders in the region under consideration of its historical legacies and present contingencies. The chosen approach to the research issue places individual employees at the centre of analysis and deals with stances and perceptions of labour. The applied relational understanding of social structures sees any economic processes as necessarily embedded in context and evolving due to past developments. Therefore, a concept of organisations and the management of work is developed that is sensitive to the particularities of long-distance commuting as used in northern Russia and the perceptions and preferences of the individuals involved. The data used in the analyses was acquired from a case study of a Russian oil company and a questionnaire survey. The respondents' views do not reveal any general rejection of long-distance commuting as an alternative employment pattern. Furthermore, its acceptance can be enhanced by listening to the voices of those directly involved. Long-distance commuting is therefore available as a tool for dealing with the limiting geographical characteristics of the Russian North, its Soviet legacies and for efficiently capitalising on its economic potentials. (orig.)

  6. Book Review. Finding a New Prism of Understanding the “Papua Conflict” Through Papua’s Insecurity: State Failure in the Indonesian Periphery

    Directory of Open Access Journals (Sweden)

    Maretta Kartika Sari

    2017-02-01

    Full Text Available Another international published research voicing yet the Papua quandary was written by author Bobby Anderson, a non-Indonesian research worker who has been conducting much work in the area. Published in 2015, Papua’s Insecurity: State Failure in the Indonesian Periphery is part of the Policy Studies series, an ongoing publication project by the U.S.-based education and research institution of the East-West Center. Issues of the series are based on fieldwork and academic study, that aim primarily to provide new perspectives and insights on stakeholders’ policies—and in the context of this particular publication, those in the Papua region. It is also noteworthy that the series, tallying to the platform of the above-stated organization, cover the areas of Asia and have target readers comprised particularly of policy and business communities, academics, journalists, and the informed public who probably also hold a special interest in the relations between the U.S. and the region.

  7. Social norms and cultural services - community belief system and use of wildlife products in the Northern periphery of the Korup National Park, South-West Cameroon

    Directory of Open Access Journals (Sweden)

    Ngoufo R

    2014-06-01

    Full Text Available In many traditional societies, beliefs and taboos influence human behaviour towards the natural environment. Such beliefs and taboos are informal institutions where norms rather than official laws determine land use and nature protection in general and wildlife in particular. The present study on beliefs and taboos of the people of the northern periphery of the Korup National Park is an attempt to reveal how norms influence their relation to the environment. A total of 195 households were sampled through a household survey conducted in four villages. The results revealed that before the application of “modern” approaches for wildlife protection and management, the people relied on norms to establish a relationship with wildlife and nature. The enactment of the 1994 legislation on forest, wildlife and fisheries resulted in stiff resistance as it contradicts traditional norms. It was found that 57.4 % of the respondents still perceive wildlife as a resource that can never get extinct. Traditional norms had a differentiated impact especially on game protection. The study recommends that a wildlife benefiting code of beliefs and taboos is developed to provide a basis for establishing a synergy between park management laws and traditional belief/taboo systems that drive the management of wildlife.

  8. Use of a tool-set by Pan troglodytes troglodytes to obtain termites (Macrotermes) in the periphery of the Dja Biosphere Reserve, southeast Cameroon.

    Science.gov (United States)

    Deblauwe, Isra; Guislain, Patrick; Dupain, Jef; Van Elsacker, Linda

    2006-12-01

    At the northern periphery of the Dja Biosphere Reserve (southeastern Cameroon) we recorded a new use of a tool-set by Pan troglodytes troglodytes to prey on Macrotermes muelleri, M. renouxi, M. lilljeborgi, and M. nobilis. We recovered 79 puncturing sticks and 47 fishing probes at 17 termite nests between 2002 and 2005. The mean length of the puncturing sticks (n = 77) and fishing probes (n = 45) was 52 cm and 56 cm, respectively, and the mean diameter was 9 mm and 4.5 mm, respectively. Sixty-eight percent of 138 chimpanzee fecal samples contained major soldiers of four Macrotermes species. The chimpanzees in southeastern Cameroon appeared to be selective in their choice of plant material to make their tools. The tools found at our study site resemble those from other sites in this region. However, in southeastern Cameroon only one tool-set type was found, whereas two tool-set types have been reported in Congo. Our study suggests that, along with the different vegetation types and the availability of plant material around termite nests, the nest and gallery structure and foraging behavior of the different Macrotermes spp. at all Central African sites must be investigated before we can attribute differences in tool-use behavior to culture. (c) 2006 Wiley-Liss, Inc.

  9. The dimethylarginine (ADMA)/nitric oxide pathway in the brain and periphery of rats with thioacetamide-induced acute liver failure: Modulation by histidine.

    Science.gov (United States)

    Milewski, Krzysztof; Hilgier, Wojciech; Albrecht, Jan; Zielińska, Magdalena

    2015-09-01

    Hepatic encephalopathy (HE) is related to variations in the nitric oxide (NO) synthesis and oxidative/nitrosative stress (ONS), and asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthases (NOSs). In the present study we compared the effects of acute liver failure (ALF) in the rat TAA model on ADMA concentration in plasma and cerebral cortex, and on the activity and expression of the ADMA degrading enzyme, dimethylarginine dimethylaminohydrolase (DDAH), in brain and liver. ALF increased blood and brain ADMA, and the increase was correlated with decreased DDAH activity in both brain and liver. An i.p. administration of histidine (His), an amino acid reported to alleviate oxidative stress associated with HE (100 mg/kg b.w.), reversed the increase of brain ADMA, which was accompanied by the recovery of brain DDAH activity (determined ex vivo), and with an increase of the total NOS activity. His also activated DDAH ex vivo in brain homogenates derived from control and TAA rats. ALF in this model was also accompanied by increases of blood cyclooxygenase activity and blood and brain TNF-α content, markers of the inflammatory response in the periphery, but these changes were not affected by His, except for the reduction of TNF-α mRNA transcript in the brain. His increased the total antioxidant capacity of the brain cortex, but not of the blood, further documenting its direct neuroprotective power. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Idiopathic pulmonary fibrosis may be a disease of recurrent, tractional injury to the periphery of the aging lung: a unifying hypothesis regarding etiology and pathogenesis.

    Science.gov (United States)

    Leslie, Kevin O

    2012-06-01

    Idiopathic pulmonary fibrosis is a progressive, fatal lung disease occurring in older individuals. Despite 50 years of accrued data about the disease, little progress has been made in slowing functional loss or in decreasing patient mortality. To present a novel hypothesis on the etiology and pathogenesis of idiopathic pulmonary fibrosis. Published data are reviewed regarding the epidemiology, clinical presentation, natural history, radiologic findings, and pathologic findings in patients with idiopathic pulmonary fibrosis. Patients with idiopathic pulmonary fibrosis may be predisposed genetically to tractional injury to the peripheral lung. The result is recurrent damage to the epithelial-mesenchymal interface, preferentially at the outer edges of the basilar lung lobules where tractional stress is high during inspiration, compliance is relatively low, and there is a greater tendency for alveolar collapse at end-expiration. A distinctive "reticular network of injury" (the fibroblast focus) forms, attended by a prolonged phase of wound repair (tear and slow repair). Discrete areas of alveolar collapse are observed in scar at the periphery of the lung lobules. The cycle repeats over many years resulting in progressive fibrous remodeling and replacement of the alveoli in a lobule by bronchiolar cysts surrounded by scar (honeycomb lung). Abnormalities in surfactant function are proposed as a potential mechanism of initial lung damage. Age of onset may be a function of a required threshold of environmental exposures (eg, cigarette smoking) or other comorbid injury to the aging lung. Evidence supporting this hypothesis is presented and potential mechanisms are discussed. A potential role for contributing cofactors is presented.

  11. Control coordination abilities in shock combat sports

    Directory of Open Access Journals (Sweden)

    Natalya Boychenko

    2014-12-01

    Full Text Available Purpose: optimize the process control level of coordination abilities in martial arts. Material and Methods: analysis and compilation of scientific and methodological literature, interviews with coaches of drum martial arts, video analysis techniques, teacher observations. Results: identified specific types of coordination abilities in shock combat sports. Pod branny and offered specific and nonspecific tests to monitor the level of species athletes coordination abilities. Conclusion: it is determined that in order to achieve victory in the fight martial artists to navigate the space to be able to assess and manage dynamic and spatio-temporal parameters of movements, maintain balance, have a high coordination of movements. The proposed tests to monitor species coordination abilities athletes allow an objective assessment of not only the overall level of coordination, and the level of specific types of manifestations of this ability.

  12. Photoactive devices including porphyrinoids with coordinating additives

    Science.gov (United States)

    Forrest, Stephen R; Zimmerman, Jeramy; Yu, Eric K; Thompson, Mark E; Trinh, Cong; Whited, Matthew; Diev, Vlacheslav

    2015-05-12

    Coordinating additives are included in porphyrinoid-based materials to promote intermolecular organization and improve one or more photoelectric characteristics of the materials. The coordinating additives are selected from fullerene compounds and organic compounds having free electron pairs. Combinations of different coordinating additives can be used to tailor the characteristic properties of such porphyrinoid-based materials, including porphyrin oligomers. Bidentate ligands are one type of coordinating additive that can form coordination bonds with a central metal ion of two different porphyrinoid compounds to promote porphyrinoid alignment and/or pi-stacking. The coordinating additives can shift the absorption spectrum of a photoactive material toward higher wavelengths, increase the external quantum efficiency of the material, or both.

  13. Hamiltonization of theories with degenerate coordinates

    International Nuclear Information System (INIS)

    Gitman, D.M.; Tyutin, I.V.

    2002-01-01

    We consider a class of Lagrangian theories where part of the coordinates does not have any time derivatives in the Lagrange function (we call such coordinates degenerate). We advocate that it is reasonable to reconsider the conventional definition of singularity based on the usual Hessian and, moreover, to simplify the conventional hamiltonization procedure. In particular, in such a procedure, it is not necessary to complete the degenerate coordinates with the corresponding conjugate momenta

  14. Hamiltonization of theories with degenerate coordinates

    Energy Technology Data Exchange (ETDEWEB)

    Gitman, D.M. E-mail: gitman@fma.if.usp.br; Tyutin, I.V. E-mail: tyutin@lpi.ru

    2002-05-27

    We consider a class of Lagrangian theories where part of the coordinates does not have any time derivatives in the Lagrange function (we call such coordinates degenerate). We advocate that it is reasonable to reconsider the conventional definition of singularity based on the usual Hessian and, moreover, to simplify the conventional hamiltonization procedure. In particular, in such a procedure, it is not necessary to complete the degenerate coordinates with the corresponding conjugate momenta.

  15. Convergence of barycentric coordinates to barycentric kernels

    KAUST Repository

    Kosinka, Jiří

    2016-02-12

    We investigate the close correspondence between barycentric coordinates and barycentric kernels from the point of view of the limit process when finer and finer polygons converge to a smooth convex domain. We show that any barycentric kernel is the limit of a set of barycentric coordinates and prove that the convergence rate is quadratic. Our convergence analysis extends naturally to barycentric interpolants and mappings induced by barycentric coordinates and kernels. We verify our theoretical convergence results numerically on several examples.

  16. Convergence of barycentric coordinates to barycentric kernels

    KAUST Repository

    Kosinka, Jiří ; Barton, Michael

    2016-01-01

    We investigate the close correspondence between barycentric coordinates and barycentric kernels from the point of view of the limit process when finer and finer polygons converge to a smooth convex domain. We show that any barycentric kernel is the limit of a set of barycentric coordinates and prove that the convergence rate is quadratic. Our convergence analysis extends naturally to barycentric interpolants and mappings induced by barycentric coordinates and kernels. We verify our theoretical convergence results numerically on several examples.

  17. Knowledge coordination in distributed software management

    DEFF Research Database (Denmark)

    Persson, John Stouby; Mathiassen, Lars

    2012-01-01

    Software organizations are increasingly relying on cross-organizational and cross-border collaboration, requiring effective coordination of distributed knowledge. However, such coordination is challenging due to spatial separation, diverging communities-of-practice, and unevenly distributed...... communication breakdowns on recordings of their combined teleconferencing and real-time collaborative modeling. As a result, we offer theoretical propositions that explain how distributed software managers can deal with communication breakdowns and effectively coordinate knowledge through multimodal virtual...

  18. Group Coordination Support in Networked Multimedia Systems

    National Research Council Canada - National Science Library

    Dommel, Hans-Peter

    1999-01-01

    .... In this dissertation, we address network control and coordination functions to orchestrate synchronous multimedia groupwork, establishing a sharing discipline on multimedia resources and guaranteeing...

  19. EPOS for Coordination of Asynchronous Sensor Webs

    Data.gov (United States)

    National Aeronautics and Space Administration — Develop, integrate, and deploy software-based tools to coordinate asynchronous, distributed missions and optimize observation planning spanning simultaneous...

  20. Quantization in rotating co-ordinates revisited

    International Nuclear Information System (INIS)

    Hussain, F.; Qadir, A.

    1982-07-01

    Recent work on quantization in rotating co-ordinates showed that no radiation would be seen by an observer rotating with a constant angular speed. This work used a Galilean-type co-ordinate transformation. We show that the same result holds for a Lorentz-type co-ordinate system, in spite of the fact that the metric has a co-ordinate singularity at rΩ = 1. Further, we are able to define positive and negative energy modes for a particular case of a non-static, non-stationary metric. (author)

  1. Event-by-Event Observables and Fluctuations

    International Nuclear Information System (INIS)

    Petersen, Hannah

    2013-01-01

    In this talk the status and open questions of the phenomenological description of all the stages of a heavy ion reaction are highlighted. Special emphasis is put on event-by-event fluctuations and associated observables. The first part is concentrated on high RHIC and LHC energies and the second part reviews the challenges for modeling heavy ion reactions at lower beam energies in a more realistic fashion. Overall, the main conclusion is that sophisticated theoretical dynamical approaches that describe many observables in the same framework are essential for the quantitative understanding of the properties of hot and dense nuclear matter

  2. Coordinating with the "Inner GPS".

    Science.gov (United States)

    Fenton, André A

    2015-06-01

    The 2014 Nobel Prize for Physiology or Medicine was awarded for the discoveries that have elucidated the components of the internal positioning system that is centered on the hippocampus and entorhinal cortex. Here I provide a less than objective discussion of the importance of these accomplishments to systems neuroscience. By identifying positioning components like place, direction, distance, borders and the like, the field is given the opportunity to have a shot at piecing together how these components are integrated into the synthetic positioning sense. We are also given what is in my view, the most experimentally accessible and therefore potentially understandable, cognitive representation. Lest we feel too confident in the completeness of our understanding, and to inspire redoubled curiosity, I briefly describe a preliminary observation from our work with the psychosis-inducing drug phencyclidine (PCP). While PCP does not disturb where individual place cells fire, it dramatically discoordinates how these cells discharge together in time. Trying to understand how the positioning component cells are coordinated to provide useful knowledge is an exciting and tenable problem to be working on. © 2015 Wiley Periodicals, Inc.

  3. Urban peripheries and rural centres

    DEFF Research Database (Denmark)

    Quist, Pia; Monka, Malene

    suburb. We find that in both communities the deployment of dialect serves a range of purposes among adolescents. In Vollsmose, an ethnically mixed suburb of the town of Odense, speakers use a distinct multiethnic youth style parallel to what has been described for young people in Copenhagen (e.g. Quist...

  4. The Left Periphery and Agrammatism

    DEFF Research Database (Denmark)

    Nyvad, Anne Mette; Christensen, Ken Ramshøj; Vikner, Sten

    2014-01-01

    are required, namely, A-movement (impaired) vs. A-bar-movement (not impaired), main clause CP vs. embedded clause CP (impaired), and subject vs. object. In simple clauses, object extraction is most impaired, whereas in embedded clauses, the pattern is reversed. Together these distinctions provide an account......Data from a study on the comprehension of short and long extractions by four Danish agrammatic patients reveal an interesting asymmetry between subject and object extraction that cannot be explained with canonicity or with trace deletion. It is argued that three crucial linguistic distinctions...

  5. Are Visual Peripheries Forever Young?

    Directory of Open Access Journals (Sweden)

    Kalina Burnat

    2015-01-01

    Full Text Available The paper presents a concept of lifelong plasticity of peripheral vision. Central vision processing is accepted as critical and irreplaceable for normal perception in humans. While peripheral processing chiefly carries information about motion stimuli features and redirects foveal attention to new objects, it can also take over functions typical for central vision. Here I review the data showing the plasticity of peripheral vision found in functional, developmental, and comparative studies. Even though it is well established that afferent projections from central and peripheral retinal regions are not established simultaneously during early postnatal life, central vision is commonly used as a general model of development of the visual system. Based on clinical studies and visually deprived animal models, I describe how central and peripheral visual field representations separately rely on early visual experience. Peripheral visual processing (motion is more affected by binocular visual deprivation than central visual processing (spatial resolution. In addition, our own experimental findings show the possible recruitment of coarse peripheral vision for fine spatial analysis. Accordingly, I hypothesize that the balance between central and peripheral visual processing, established in the course of development, is susceptible to plastic adaptations during the entire life span, with peripheral vision capable of taking over central processing.

  6. Are visual peripheries forever young?

    Science.gov (United States)

    Burnat, Kalina

    2015-01-01

    The paper presents a concept of lifelong plasticity of peripheral vision. Central vision processing is accepted as critical and irreplaceable for normal perception in humans. While peripheral processing chiefly carries information about motion stimuli features and redirects foveal attention to new objects, it can also take over functions typical for central vision. Here I review the data showing the plasticity of peripheral vision found in functional, developmental, and comparative studies. Even though it is well established that afferent projections from central and peripheral retinal regions are not established simultaneously during early postnatal life, central vision is commonly used as a general model of development of the visual system. Based on clinical studies and visually deprived animal models, I describe how central and peripheral visual field representations separately rely on early visual experience. Peripheral visual processing (motion) is more affected by binocular visual deprivation than central visual processing (spatial resolution). In addition, our own experimental findings show the possible recruitment of coarse peripheral vision for fine spatial analysis. Accordingly, I hypothesize that the balance between central and peripheral visual processing, established in the course of development, is susceptible to plastic adaptations during the entire life span, with peripheral vision capable of taking over central processing.

  7. Muslims at the Australian periphery

    Directory of Open Access Journals (Sweden)

    Linda Briskman

    2017-01-01

    Full Text Available The overt expression of anti-Muslim sentiment is a relatively new phenomenon in Australia. It builds upon racism embedded in history, “clash of civilisations” ideologies and constructs of border-terrorism. Denigration of Muslims, commonly termed Islamophobia, is overtly evident in the official sphere, media reporting and increasing popular rejection of Islamic amenities such as schools and mosques. Connected but more insidious is the Islamophobia of the ‘white savior rescue’ movement, in which Muslim men and Islam are positioned as perpetrators of oppression and harm toward Muslim women, requiring non-Muslim intervention. Varied forms of Islamophobia and their impacts are discussed.

  8. Multi Agent System Based Wide Area Protection against Cascading Events

    DEFF Research Database (Denmark)

    Liu, Zhou; Chen, Zhe; Liu, Leo

    2012-01-01

    In this paper, a multi-agent system based wide area protection scheme is proposed in order to prevent long term voltage instability induced cascading events. The distributed relays and controllers work as a device agent which not only executes the normal function automatically but also can...... the effectiveness of proposed protection strategy. The simulation results indicate that the proposed multi agent control system can effectively coordinate the distributed relays and controllers to prevent the long term voltage instability induced cascading events....

  9. Organotypic three-dimensional culture model of mesenchymal and epithelial cells to examine tissue fusion events.

    Science.gov (United States)

    Tissue fusion during early mammalian development requires coordination of multiple cell types, the extracellular matrix, and complex signaling pathways. Fusion events during processes including heart development, neural tube closure, and palatal fusion are dependent on signaling ...

  10. Vaidya spacetime in the diagonal coordinates

    Energy Technology Data Exchange (ETDEWEB)

    Berezin, V. A., E-mail: berezin@inr.ac.ru; Dokuchaev, V. I., E-mail: dokuchaev@inr.ac.ru; Eroshenko, Yu. N., E-mail: eroshenko@inr.ac.ru [Russian Academy of Sciences, Institute for Nuclear Research (Russian Federation)

    2017-03-15

    We have analyzed the transformation from initial coordinates (v, r) of the Vaidya metric with light coordinate v to the most physical diagonal coordinates (t, r). An exact solution has been obtained for the corresponding metric tensor in the case of a linear dependence of the mass function of the Vaidya metric on light coordinate v. In the diagonal coordinates, a narrow region (with a width proportional to the mass growth rate of a black hole) has been detected near the visibility horizon of the Vaidya accreting black hole, in which the metric differs qualitatively from the Schwarzschild metric and cannot be represented as a small perturbation. It has been shown that, in this case, a single set of diagonal coordinates (t, r) is insufficient to cover the entire range of initial coordinates (v, r) outside the visibility horizon; at least three sets of diagonal coordinates are required, the domains of which are separated by singular surfaces on which the metric components have singularities (either g{sub 00} = 0 or g{sub 00} = ∞). The energy–momentum tensor diverges on these surfaces; however, the tidal forces turn out to be finite, which follows from an analysis of the deviation equations for geodesics. Therefore, these singular surfaces are exclusively coordinate singularities that can be referred to as false fire-walls because there are no physical singularities on them. We have also considered the transformation from the initial coordinates to other diagonal coordinates (η, y), in which the solution is obtained in explicit form, and there is no energy–momentum tensor divergence.

  11. Identifying jet quantum numbers event by event

    International Nuclear Information System (INIS)

    Teper, M.J.

    1979-12-01

    A method is proposed to identify the parton that gives rise to any particular jet. The method improves with the number of particles in the jet, and should indicate which of the jets in a three jet event at PETRA is the gluon jet. (author)

  12. On superfield covariant quantization in general coordinates

    International Nuclear Information System (INIS)

    Gitman, D.M.; Moshin, P. Yu.; Tomazelli, J.L.

    2005-01-01

    We propose a natural extension of the BRST-antiBRST superfield covariant scheme in general coordinates. Thus, the coordinate dependence of the basic tensor fields and scalar density of the formalism is extended from the base supermanifold to the complete set of superfield variables. (orig.)

  13. On superfield covariant quantization in general coordinates

    Energy Technology Data Exchange (ETDEWEB)

    Gitman, D.M. [Universidade de Sao Paulo, Instituto de Fisica, Sao Paulo, S.P (Brazil); Moshin, P. Yu. [Universidade de Sao Paulo, Instituto de Fisica, Sao Paulo, S.P (Brazil); Tomsk State Pedagogical University, Tomsk (Russian Federation); Tomazelli, J.L. [UNESP, Departamento de Fisica e Quimica, Campus de Guaratingueta (Brazil)

    2005-12-01

    We propose a natural extension of the BRST-antiBRST superfield covariant scheme in general coordinates. Thus, the coordinate dependence of the basic tensor fields and scalar density of the formalism is extended from the base supermanifold to the complete set of superfield variables. (orig.)

  14. Self-triggered coordination with ternary controllers

    NARCIS (Netherlands)

    De Persis, Claudio; Frasca, Paolo

    2012-01-01

    This paper regards coordination of networked systems with ternary controllers. We develop a hybrid coordination system which implements a self-triggered communication policy, based on polling the neighbors upon need. We prove that the proposed scheme ensures finite-time convergence to a neighborhood

  15. Politics of coordination in environmental health

    DEFF Research Database (Denmark)

    Holm, Jesper; Kjærgård, Bente; Jelsøe, Erling

    2015-01-01

    on environmental policy integration, for studying the efforts and paradoxes in sector co-ordination, in order to reflect on the pro et cons of integrative approaches to environment and public health. We will give an overview of the various approaches to coordinative efforts from an international to a national...

  16. Project Coordinator - Karianet | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Primary Duties or Responsibilities. The specific responsibilities of the Project Coordinator are grouped into three categories: Knowledge Management, Research Management and Project Management. As Knowledge Manager, the program coordinator will play a lead role in: Introducing and using knowledge management ...

  17. Energy Materials Coordinating Committee (EMaCC)

    Energy Technology Data Exchange (ETDEWEB)

    1991-05-31

    This report summarizes EMaCC activities for fiscal year 1990 and describes the materials research programs of various offices and divisions within the department. The DOE Energy Materials Coordinating Committee (EMaCC) serves primarily to enhance coordination among the Department's materials programs and to further the effective use of materials expertise within the department. (JL)

  18. Conventions and institutions in coordination problems

    NARCIS (Netherlands)

    van der Lecq, S.G.

    1996-01-01

    This survey article starts with a game-theory interpretation of coordination problems that occur in an economy. Three types of games are discussed in which the degree of coordination versus conflict varies. It is shown that game-theoretic techniques for equilibrium selection or securing the highest

  19. 78 FR 73819 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2013-12-09

    ... DEPARTMENT OF AGRICULTURE Forest Service Forest Resource Coordinating Committee AGENCY: Forest Service, USDA. ACTION: Notice of Cancellation. SUMMARY: The U.S. Department of Agriculture, Forest Service was required to cancel the October 17-18, 2013 meeting of the Forest Resource Coordinating Committee...

  20. 78 FR 57128 - Forest Resource Coordinating Committee

    Science.gov (United States)

    2013-09-17

    ... agencies and the private sector, to effectively address the national priorities for non-industrial private... Coordinating Committee Web site at http://www.fs.fed.us/spf/coop/frcc/ . Visitors are encouraged to call ahead... Resource Coordinating Committee can be found by visiting the Committee's Web site at: http://www.fs.fed.us...

  1. You're a "What"? Recycling Coordinator

    Science.gov (United States)

    Torpey, Elka Maria

    2011-01-01

    Recycling coordinators supervise curbside and dropoff recycling programs for municipal governments or private firms. Today, recycling is mandatory in many communities. And advancements in collection and processing methods have helped to increase the quantity of materials for which the recycling coordinator is responsible. In some communities,…

  2. 40 CFR 35.272 - Funding coordination.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Funding coordination. 35.272 Section 35.272 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE....272 Funding coordination. Recipients must use the lead-based paint program funding in a way that...

  3. 40 CFR 35.691 - Funding coordination.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Funding coordination. 35.691 Section 35.691 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE...(g)) § 35.691 Funding coordination. Recipients must use the Lead-Based Paint program funding in a way...

  4. 40 CFR 233.31 - Coordination requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Coordination requirements. 233.31 Section 233.31 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) OCEAN DUMPING 404 STATE PROGRAM REGULATIONS Program Operation § 233.31 Coordination requirements. (a) If a proposed...

  5. 7 CFR 624.5 - Coordination.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Coordination. 624.5 Section 624.5 Agriculture Regulations of the Department of Agriculture (Continued) NATURAL RESOURCES CONSERVATION SERVICE, DEPARTMENT OF AGRICULTURE WATER RESOURCES EMERGENCY WATERSHED PROTECTION § 624.5 Coordination. (a) If the President declares...

  6. Vendor-Buyer Coordination in Supply Chains

    NARCIS (Netherlands)

    H.J.J. Verheijen (Bas)

    2010-01-01

    textabstractCollaboration between firms in order to coordinate supply chain operations can lead to both strategic and operational benefits. Many advanced forms of collaboration arrangements between firms exist with the aim to coordinate supply chain decisions and to reap these benefits. This

  7. Soundscapes, events, resistance

    Directory of Open Access Journals (Sweden)

    Andrea Mubi Brighenti

    2008-12-01

    Full Text Available Put it bluntly, a soundscape is the sonic counterpart, or component, of landscape. From such minimal assumption, some interesting consequences follow: just as landscape is far from being a simple stage-set upon which events take place, soundscape, too, is itself evental, i.e., it consists of events. Not only because its nature, far from being acoustics is always ‘psychoacoustics’, as Murray Schafer (1977/1994 first argued. Processes of environmental perception are of course there.

  8. Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY-cleaving peptidases and potential drug interactions in CNS and Periphery.

    Science.gov (United States)

    Wagner, Leona; Wolf, Raik; Zeitschel, Ulrike; Rossner, Steffen; Petersén, Åsa; Leavitt, Blair R; Kästner, Florian; Rothermundt, Matthias; Gärtner, Ulf-Torsten; Gündel, Daniel; Schlenzig, Dagmar; Frerker, Nadine; Schade, Jutta; Manhart, Susanne; Rahfeld, Jens-Ulrich; Demuth, Hans-Ulrich; von Hörsten, Stephan

    2015-12-01

    The bioactivity of neuropeptide Y (NPY) is either N-terminally modulated with respect to receptor selectivity by dipeptidyl peptidase 4 (DP4)-like enzymes or proteolytic degraded by neprilysin or meprins, thereby abrogating signal transduction. However, neither the subcellular nor the compartmental differentiation of these regulatory mechanisms is fully understood. Using mass spectrometry, selective inhibitors and histochemistry, studies across various cell types, body fluids, and tissues revealed that most frequently DP4-like enzymes, aminopeptidases P, secreted meprin-A (Mep-A), and cathepsin D (CTSD) rapidly hydrolyze NPY, depending on the cell type and tissue under study. Novel degradation of NPY by cathepsins B, D, L, G, S, and tissue kallikrein could also be identified. The expression of DP4, CTSD, and Mep-A at the median eminence indicates that the bioactivity of NPY is regulated by peptidases at the interphase between the periphery and the CNS. Detailed ex vivo studies on human sera and CSF samples recognized CTSD as the major NPY-cleaving enzyme in the CSF, whereas an additional C-terminal truncation by angiotensin-converting enzyme could be detected in serum. The latter finding hints to potential drug interaction between antidiabetic DP4 inhibitors and anti-hypertensive angiotensin-converting enzyme inhibitors, while it ablates suspected hypertensive side effects of only antidiabetic DP4-inhibitors application. The bioactivity of neuropeptide Y (NPY) is either N-terminally modulated with respect to receptor selectivity by dipeptidyl peptidase 4 (DP4)-like enzymes or proteolytic degraded by neprilysin or meprins, thereby abrogating signal transduction. However, neither the subcellular nor the compartmental differentiation of these regulatory mechanisms is fully understood. Using mass spectrometry, selective inhibitors and histochemistry, studies across various cell types, body fluids, and tissues revealed that most frequently DP4-like enzymes

  9. Evaluation of vertical coordinate and vertical mixing algorithms in the HYbrid-Coordinate Ocean Model (HYCOM)

    Science.gov (United States)

    Halliwell, George R.

    Vertical coordinate and vertical mixing algorithms included in the HYbrid Coordinate Ocean Model (HYCOM) are evaluated in low-resolution climatological simulations of the Atlantic Ocean. The hybrid vertical coordinates are isopycnic in the deep ocean interior, but smoothly transition to level (pressure) coordinates near the ocean surface, to sigma coordinates in shallow water regions, and back again to level coordinates in very shallow water. By comparing simulations to climatology, the best model performance is realized using hybrid coordinates in conjunction with one of the three available differential vertical mixing models: the nonlocal K-Profile Parameterization, the NASA GISS level 2 turbulence closure, and the Mellor-Yamada level 2.5 turbulence closure. Good performance is also achieved using the quasi-slab Price-Weller-Pinkel dynamical instability model. Differences among these simulations are too small relative to other errors and biases to identify the "best" vertical mixing model for low-resolution climate simulations. Model performance deteriorates slightly when the Kraus-Turner slab mixed layer model is used with hybrid coordinates. This deterioration is smallest when solar radiation penetrates beneath the mixed layer and when shear instability mixing is included. A simulation performed using isopycnic coordinates to emulate the Miami Isopycnic Coordinate Ocean Model (MICOM), which uses Kraus-Turner mixing without penetrating shortwave radiation and shear instability mixing, demonstrates that the advantages of switching from isopycnic to hybrid coordinates and including more sophisticated turbulence closures outweigh the negative numerical effects of maintaining hybrid vertical coordinates.

  10. Coordinated School Health and the Contribution of a District Wellness Coordinator

    Science.gov (United States)

    Westrich, Lisa; Sanchez, Monika; Strobel, Karen

    2015-01-01

    Background: A San Francisco Bay Area school health initiative was established in fall 2010 to improve wellness programs in 4 local school districts using the Coordinated School Health (CSH) model. This study examines the role of district-wide wellness coordinators and the ways in which they contribute to intentional coordination of health and…

  11. Relational Coordination in Danish General Practice

    DEFF Research Database (Denmark)

    Lundstrøm, Sanne Lykke

    . The dissertation present the research study and a collection of three research papers prepared during the period from May 2010 to June 2014. Relational coordination and organisational social capital are measures of novel aspects of an organisation's performance. Relational coordination analyse the communication...... and relationship networks through which work is coordinated across functional and organisational boundaries. Previous studies have shown that relational coordination is positively associated with delivery of care for patients with chronic illness. Organisational social capital is used when analysing...... the psychosocial work environment in organisations, and is seen as a powerful resources for improving organisational performance. Relational coordination and organisational social capital may oer new insight and opportunities for general practice to learn. General practice provides cost-efficient, first...

  12. Coordinate metrology accuracy of systems and measurements

    CERN Document Server

    Sładek, Jerzy A

    2016-01-01

    This book focuses on effective methods for assessing the accuracy of both coordinate measuring systems and coordinate measurements. It mainly reports on original research work conducted by Sladek’s team at Cracow University of Technology’s Laboratory of Coordinate Metrology. The book describes the implementation of different methods, including artificial neural networks, the Matrix Method, the Monte Carlo method and the virtual CMM (Coordinate Measuring Machine), and demonstrates how these methods can be effectively used in practice to gauge the accuracy of coordinate measurements. Moreover, the book includes an introduction to the theory of measurement uncertainty and to key techniques for assessing measurement accuracy. All methods and tools are presented in detail, using suitable mathematical formulations and illustrated with numerous examples. The book fills an important gap in the literature, providing readers with an advanced text on a topic that has been rapidly developing in recent years. The book...

  13. Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation†

    Science.gov (United States)

    Selvam, Shanmugam P.; De Palma, Ryan M.; Oaks, Joshua J.; Oleinik, Natalia; Peterson, Yuri K.; Stahelin, Robert V.; Skordalakes, Emmanuel; Ponnusamy, Suriyan; Garrett-Mayer, Elizabeth; Smith, Charles D.; Ogretmen, Besim

    2015-01-01

    During DNA replication, the enzyme telomerase maintains the ends of chromosomes, called telomeres. Shortened telomeres trigger cell senescence, and cancer cells often have increased telomerase activity to promote their ability to proliferate indefinitely. The catalytic subunit, human telomerase reverse transcriptase (hTERT), is stabilized by phosphorylation. Here, we found that the lysophospholipid sphingosine 1-phosphate (S1P), generated by sphingosine kinase 2 (SK2), bound hTERT at the nuclear periphery in human and mouse fibroblasts. Docking predictions and mutational analyses revealed that binding occurred between a hydroxyl group (C′3-OH) in S1P and Asp684 in hTERT. Inhibiting or depleting SK2 or mutating the S1P binding site decreased the stability of hTERT in cultured cells and promoted senescence and loss of telomere integrity. S1P binding inhibited the interaction of hTERT with MKRN1, an E3 ubiquitin ligase that tags hTERT for degradation. Murine Lewis lung carcinoma (LLC) cells formed smaller tumors in mice lacking SK2 than in wild-type mice, and knocking down SK2 in LLC cells before implantation into mice suppressed their growth. Pharmacologically inhibiting SK2 decreased the growth of subcutaneous A549 lung cancer cell-derived xenografts in mice, and expression of wild-type hTERT, but not an S1P-binding mutant, restored tumor growth. Thus, our data suggest that S1P binding to hTERT allosterically mimicks phosphorylation, promoting telomerase stability and hence telomere maintenance, cell proliferation, and tumor growth PMID:26082434

  14. Dark and Photoinduced Cytotoxic Activity of the New Chlorophyll-a Derivatives with Oligoethylene Glycol Substituents on the Periphery of Their Macrocycles.

    Science.gov (United States)

    Pylina, Yana I; Shadrin, Dmitry M; Shevchenko, Oksana G; Startseva, Olga M; Velegzhaninov, Igor O; Belykh, Dmitry V; Velegzhaninov, Ilya O

    2017-01-05

    In the present work, we investigated the dark and photoinduced cytotoxic activity of the new chlorophyll-a derivatives which contain the substituents of oligoethylene glycol on the periphery of their macrocycles. These compounds were tested using human cell lines to estimate their potential as photosensitizers for photodynamic therapy of cancer. It was shown that all the tested compounds have expressed photoinduced cytotoxic activity in vitro. Detailed study of the biological activity of one of the most perspective compound in this series-pyropheophorbide-a 17-diethylene glycol ester (Compound 21 ) was performed. This new compound is characterized by lower dark cytotoxicity and higher photoinduced cytotoxicity than previously described in a similar compound (DH-I-180-3) and clinically used Photolon TM . Using fluorescent microscopy, it was shown that Compound 21 quickly penetrates the cells. Analysis of caspase-3 activity indicated an apoptosis induction 40 min after exposure to red light (λ = 660 nm). The induction of DNA damages and apoptosis was shown using Comet assay. The results of expression analysis of the stress-response genes indicate an activation of the genes which control the cell cycle and detoxification of the free radicals after an exposure of HeLa cells to Compound 21 and to red light. High photodynamic activity of this compound and the ability to oxidize biomolecules was demonstrated on nuclear-free mice erythrocytes. In addition, it was shown that Compound 21 is effectively activated with low energy 700 nm light, which can penetrate deep into the tissue. Thus, Compound 21 is a prospective substance for development of the new drugs for photodynamic therapy of cancer.

  15. Dark and Photoinduced Cytotoxic Activity of the New Chlorophyll-a Derivatives with Oligoethylene Glycol Substituents on the Periphery of Their Macrocycles

    Directory of Open Access Journals (Sweden)

    Yana I. Pylina

    2017-01-01

    Full Text Available In the present work, we investigated the dark and photoinduced cytotoxic activity of the new chlorophyll-a derivatives which contain the substituents of oligoethylene glycol on the periphery of their macrocycles. These compounds were tested using human cell lines to estimate their potential as photosensitizers for photodynamic therapy of cancer. It was shown that all the tested compounds have expressed photoinduced cytotoxic activity in vitro. Detailed study of the biological activity of one of the most perspective compound in this series—pyropheophorbide-a 17-diethylene glycol ester (Compound 21 was performed. This new compound is characterized by lower dark cytotoxicity and higher photoinduced cytotoxicity than previously described in a similar compound (DH-I-180-3 and clinically used PhotolonTM. Using fluorescent microscopy, it was shown that Compound 21 quickly penetrates the cells. Analysis of caspase-3 activity indicated an apoptosis induction 40 min after exposure to red light (λ = 660 nm. The induction of DNA damages and apoptosis was shown using Comet assay. The results of expression analysis of the stress-response genes indicate an activation of the genes which control the cell cycle and detoxification of the free radicals after an exposure of HeLa cells to Compound 21 and to red light. High photodynamic activity of this compound and the ability to oxidize biomolecules was demonstrated on nuclear-free mice erythrocytes. In addition, it was shown that Compound 21 is effectively activated with low energy 700 nm light, which can penetrate deep into the tissue. Thus, Compound 21 is a prospective substance for development of the new drugs for photodynamic therapy of cancer.

  16. The shallow water equations in Lagrangian coordinates

    International Nuclear Information System (INIS)

    Mead, J.L.

    2004-01-01

    Recent advances in the collection of Lagrangian data from the ocean and results about the well-posedness of the primitive equations have led to a renewed interest in solving flow equations in Lagrangian coordinates. We do not take the view that solving in Lagrangian coordinates equates to solving on a moving grid that can become twisted or distorted. Rather, the grid in Lagrangian coordinates represents the initial position of particles, and it does not change with time. We apply numerical methods traditionally used to solve differential equations in Eulerian coordinates, to solve the shallow water equations in Lagrangian coordinates. The difficulty with solving in Lagrangian coordinates is that the transformation from Eulerian coordinates results in solving a highly nonlinear partial differential equation. The non-linearity is mainly due to the Jacobian of the coordinate transformation, which is a precise record of how the particles are rotated and stretched. The inverse Jacobian must be calculated, thus Lagrangian coordinates cannot be used in instances where the Jacobian vanishes. For linear (spatial) flows we give an explicit formula for the Jacobian and describe the two situations where the Lagrangian shallow water equations cannot be used because either the Jacobian vanishes or the shallow water assumption is violated. We also prove that linear (in space) steady state solutions of the Lagrangian shallow water equations have Jacobian equal to one. In the situations where the shallow water equations can be solved in Lagrangian coordinates, accurate numerical solutions are found with finite differences, the Chebyshev pseudospectral method, and the fourth order Runge-Kutta method. The numerical results shown here emphasize the need for high order temporal approximations for long time integrations

  17. Features, Events, and Processes: Disruptive Events

    International Nuclear Information System (INIS)

    J. King

    2004-01-01

    The primary purpose of this analysis is to evaluate seismic- and igneous-related features, events, and processes (FEPs). These FEPs represent areas of natural system processes that have the potential to produce disruptive events (DE) that could impact repository performance and are related to the geologic processes of tectonism, structural deformation, seismicity, and igneous activity. Collectively, they are referred to as the DE FEPs. This evaluation determines which of the DE FEPs are excluded from modeling used to support the total system performance assessment for license application (TSPA-LA). The evaluation is based on the data and results presented in supporting analysis reports, model reports, technical information, or corroborative documents that are cited in the individual FEP discussions in Section 6.2 of this analysis report

  18. Features, Events, and Processes: Disruptive Events

    Energy Technology Data Exchange (ETDEWEB)

    J. King

    2004-03-31

    The primary purpose of this analysis is to evaluate seismic- and igneous-related features, events, and processes (FEPs). These FEPs represent areas of natural system processes that have the potential to produce disruptive events (DE) that could impact repository performance and are related to the geologic processes of tectonism, structural deformation, seismicity, and igneous activity. Collectively, they are referred to as the DE FEPs. This evaluation determines which of the DE FEPs are excluded from modeling used to support the total system performance assessment for license application (TSPA-LA). The evaluation is based on the data and results presented in supporting analysis reports, model reports, technical information, or corroborative documents that are cited in the individual FEP discussions in Section 6.2 of this analysis report.

  19. Safeguards summary event list (SSEL)

    International Nuclear Information System (INIS)

    Davidson, J.J.; MacMurdy, P.H.

    1980-12-01

    The List contains nine categories of events involving NRC licensed material or licensees. It is deliberately broad in scope for two main reasons. First, the list is designed to serve as a reference document. It is as complete and accurate as possible. Second, the list is intended to provide as broad a perspective of the nature of licensee-related events as possible. The nine categories of events are as follows: bomb-related events; intrusion events; missing and/or allegedly stolen events; transportation-related events; vandalism events; arson events; firearms-related events; sabotage events; and miscellaneous events

  20. Features, Events, and Processes: Disruptive Events

    Energy Technology Data Exchange (ETDEWEB)

    P. Sanchez

    2004-11-08

    The purpose of this analysis report is to evaluate and document the inclusion or exclusion of the disruptive events features, events, and processes (FEPs) with respect to modeling used to support the total system performance assessment for license application (TSPA-LA). A screening decision, either ''Included'' or ''Excluded,'' is given for each FEP, along with the technical basis for screening decisions. This information is required by the U.S. Nuclear Regulatory Commission (NRC) at 10 CFR 63.114 (d), (e), and (f) [DIRS 156605]. The FEPs addressed in this report deal with both seismic and igneous disruptive events, such as fault displacements through the repository and an igneous intrusion into the repository. For included FEPs, this analysis summarizes the implementation of the FEP in TSPA-LA (i.e., how the FEP is included). For excluded FEPs, this analysis provides the technical basis for exclusion from TSPA-LA (i.e., why the FEP is excluded). Previous versions of this report were developed to support the total system performance assessments (TSPA) for various prior repository designs. This revision addresses the repository design for the license application (LA).

  1. Features, Events, and Processes: Disruptive Events

    International Nuclear Information System (INIS)

    P. Sanchez

    2004-01-01

    The purpose of this analysis report is to evaluate and document the inclusion or exclusion of the disruptive events features, events, and processes (FEPs) with respect to modeling used to support the total system performance assessment for license application (TSPA-LA). A screening decision, either ''Included'' or ''Excluded,'' is given for each FEP, along with the technical basis for screening decisions. This information is required by the U.S. Nuclear Regulatory Commission (NRC) at 10 CFR 63.114 (d), (e), and (f) [DIRS 156605]. The FEPs addressed in this report deal with both seismic and igneous disruptive events, such as fault displacements through the repository and an igneous intrusion into the repository. For included FEPs, this analysis summarizes the implementation of the FEP in TSPA-LA (i.e., how the FEP is included). For excluded FEPs, this analysis provides the technical basis for exclusion from TSPA-LA (i.e., why the FEP is excluded). Previous versions of this report were developed to support the total system performance assessments (TSPA) for various prior repository designs. This revision addresses the repository design for the license application (LA)

  2. Drivers of flood damage on event level

    DEFF Research Database (Denmark)

    Kreibich, H.; Aerts, J. C. J. H.; Apel, H.

    2016-01-01

    example are the 2002 and 2013 floods in the Elbe and Danube catchments in Germany. The 2002 flood caused the highest economic damage (EUR 11600 million) due to a natural hazard event in Germany. Damage was so high due to extreme flood hazard triggered by extreme precipitation and a high number......-level mitigation measures, 3) more effective early warning and improved coordination of disaster response and 4) a more targeted maintenance of flood defence systems and their deliberate relocation. Thus, despite higher hydrological severity damage due to the 2013 flood was significantly lower than in 2002. In our...

  3. Human Performance Event Database

    International Nuclear Information System (INIS)

    Trager, E. A.

    1998-01-01

    The purpose of this paper is to describe several aspects of a Human Performance Event Database (HPED) that is being developed by the Nuclear Regulatory Commission. These include the background, the database structure and basis for the structure, the process for coding and entering event records, the results of preliminary analyses of information in the database, and plans for the future. In 1992, the Office for Analysis and Evaluation of Operational Data (AEOD) within the NRC decided to develop a database for information on human performance during operating events. The database was needed to help classify and categorize the information to help feedback operating experience information to licensees and others. An NRC interoffice working group prepared a list of human performance information that should be reported for events and the list was based on the Human Performance Investigation Process (HPIP) that had been developed by the NRC as an aid in investigating events. The structure of the HPED was based on that list. The HPED currently includes data on events described in augmented inspection team (AIT) and incident investigation team (IIT) reports from 1990 through 1996, AEOD human performance studies from 1990 through 1993, recent NRR special team inspections, and licensee event reports (LERs) that were prepared for the events. (author)

  4. The Agency of Event

    DEFF Research Database (Denmark)

    Nicholas, Paul; Tamke, Martin; Riiber, Jacob

    2014-01-01

    This paper explores the notion of agency within event-based models. We present an event-based modeling approach that links interdependent generative, analytic and decision making sub-models within a system of exchange. Two case study projects demonstrate the underlying modeling concepts and metho...

  5. Intermediate mass dimuon events

    International Nuclear Information System (INIS)

    Moser, H.-G.

    1985-01-01

    We report the observation of 67 dimuon events at the CERN p anti p collider with the UA1 detector. The events will be interpreted in terms of the Drell-Yan mechanism, J/PSI and UPSILON decays and heavy flavour production. (author)

  6. The Blayais event

    International Nuclear Information System (INIS)

    2000-01-01

    This document provides the main events occurred to the Blayais installation during the year 2000. For each events, the detailed chronology, the situation analysis, the crisis management and the public information are provided. Some recommendations are also provided by the nuclear safety authorities. (A.L.B.)

  7. Movement constraints on interpersonal coordination and communication.

    Science.gov (United States)

    Tolston, Michael T; Shockley, Kevin; Riley, Michael A; Richardson, Michael J

    2014-10-01

    The present study investigated how constraining movement affects interpersonal coordination and joint cognitive performance. Pairs of participants worked cooperatively to solve picture-puzzle tasks in which they conversed to identify differences between pictures in 3 degree-of-constraint conditions: both participants were free to move their hands (free-free; FF); both participants' hands were restrained (restrained-restrained; RR); and the hands of 1 participant were free while the hands of the other participant were restrained (free-restrained; FR). Eye tracking data were collected, and movement was measured at the waist, hand, and head. Data were analyzed using Cross-Recurrence Quantification Analysis (CRQ). Postural sway coordination, gaze coordination, and task performance were predicted to be highest in FF, followed by RR, and then by FR. Results showed the asymmetric FR condition generally exhibited lesser degrees of coordination than the symmetric Conditions FF and RR, and that the patterning of coordination in the symmetric conditions varied across the measured body segments. These results demonstrate that movement restraints affect not only interpersonal postural coordination, but also joint attention. Additionally, significant positive relationships were found between task performance and total amount of anterior-posterior movement measured at the head, hand and waist; number of utterances; and number of differences pairs found in the puzzles. These findings indicate a relationship between movement and task performance consistent with the hypotheses that both interpersonal coordination and cognitive performance are sensitive to local action constraints.

  8. Near-Horizon Geodesics for Astrophysical and Idealised Black Holes: Coordinate Velocity and Coordinate Acceleration

    Directory of Open Access Journals (Sweden)

    Petarpa Boonserm

    2018-05-01

    Full Text Available Geodesics (by definition have an intrinsic 4-acceleration zero. However, when expressed in terms of coordinates, the coordinate acceleration d 2 x i / d t 2 can very easily be non-zero, and the coordinate velocity d x i / d t can behave unexpectedly. The situation becomes extremely delicate in the near-horizon limit—for both astrophysical and idealised black holes—where an inappropriate choice of coordinates can quite easily lead to significant confusion. We shall carefully explore the relative merits of horizon-penetrating versus horizon-non-penetrating coordinates, arguing that in the near-horizon limit the coordinate acceleration d 2 x i / d t 2 is best interpreted in terms of horizon-penetrating coordinates.

  9. Short-Term Impact of a Comprehensive Smoke-Free Law Following a Partial Smoke-Free Law on PM2.5 Concentration Levels at Hospitality Venues on the Peripheries of College Campuses

    Directory of Open Access Journals (Sweden)

    Sol Yu

    2015-11-01

    Full Text Available Tobacco-free policies on college campuses are spreading in Korea. However, the impact of the smoking ban legislation at venues on the boundary of a college campus is still limited. This study aimed to assess short-term changes in PM2.5 concentrations before and after the enactment of the smoking ban legislation to evaluate the impact. In this cross-sectional study, PM2.5 measurements (pre-ban: n = 99, post-ban: n = 64 were conducted in randomly selected billiards, pubs, and computer game rooms on the peripheries of college campuses in October 2013, prior to implementation of the smoking ban, and in May 2014, after the ban. The median (interquartile range, IQR of the PM2.5 concentration for all venues was 31 μg/m3 (0–80 μg/m3 in the pre-ban period and 11 μg/m3 (0–36 μg/m3 in the post-ban period implying indoor PM2.5 concentration levels of the peripheries of college campuses likely decreased one year after implementation of the ban. However, the differences were not significant yet. The results support the introduction of more rigorous monitoring of SHS exposure levels toward the ultimate goal of encouraging a complete smoking ban in hospitality venues, including billiards, pubs, and computer game rooms located on the peripheries of college campuses.

  10. Short-Term Impact of a Comprehensive Smoke-Free Law Following a Partial Smoke-Free Law on PM2.5 Concentration Levels at Hospitality Venues on the Peripheries of College Campuses

    Science.gov (United States)

    Yu, Sol; Yang, Wonho; Lee, Kiyoung; Kim, Sungcheon; Ha, Kwonchul; Kim, Sungroul

    2015-01-01

    Tobacco-free policies on college campuses are spreading in Korea. However, the impact of the smoking ban legislation at venues on the boundary of a college campus is still limited. This study aimed to assess short-term changes in PM2.5 concentrations before and after the enactment of the smoking ban legislation to evaluate the impact. In this cross-sectional study, PM2.5 measurements (pre-ban: n = 99, post-ban: n = 64) were conducted in randomly selected billiards, pubs, and computer game rooms on the peripheries of college campuses in October 2013, prior to implementation of the smoking ban, and in May 2014, after the ban. The median (interquartile range, IQR) of the PM2.5 concentration for all venues was 31 μg/m3 (0–80 μg/m3) in the pre-ban period and 11 μg/m3 (0–36 μg/m3) in the post-ban period implying indoor PM2.5 concentration levels of the peripheries of college campuses likely decreased one year after implementation of the ban. However, the differences were not significant yet. The results support the introduction of more rigorous monitoring of SHS exposure levels toward the ultimate goal of encouraging a complete smoking ban in hospitality venues, including billiards, pubs, and computer game rooms located on the peripheries of college campuses. PMID:26540063

  11. Short-Term Impact of a Comprehensive Smoke-Free Law Following a Partial Smoke-Free Law on PM₂.₅ Concentration Levels at Hospitality Venues on the Peripheries of College Campuses.

    Science.gov (United States)

    Yu, Sol; Yang, Wonho; Lee, Kiyoung; Kim, Sungcheon; Ha, Kwonchul; Kim, Sungroul

    2015-11-02

    Tobacco-free policies on college campuses are spreading in Korea. However, the impact of the smoking ban legislation at venues on the boundary of a college campus is still limited. This study aimed to assess short-term changes in PM2.5 concentrations before and after the enactment of the smoking ban legislation to evaluate the impact. In this cross-sectional study, PM2.5 measurements (pre-ban: n = 99, post-ban: n = 64) were conducted in randomly selected billiards, pubs, and computer game rooms on the peripheries of college campuses in October 2013, prior to implementation of the smoking ban, and in May 2014, after the ban. The median (interquartile range, IQR) of the PM2.5 concentration for all venues was 31 μg/m³ (0-80 μg/m³) in the pre-ban period and 11 μg/m³ (0-36 μg/m³) in the post-ban period implying indoor PM2.5 concentration levels of the peripheries of college campuses likely decreased one year after implementation of the ban. However, the differences were not significant yet. The results support the introduction of more rigorous monitoring of SHS exposure levels toward the ultimate goal of encouraging a complete smoking ban in hospitality venues, including billiards, pubs, and computer game rooms located on the peripheries of college campuses.

  12. 9th Conference on Coordinate Measuring Machines

    DEFF Research Database (Denmark)

    De Chiffre, Leonardo; Dorph, Pernille

    2001-01-01

    This one-day conference on coordinate measuring machines is the 9th in a row of conferences organised in connection with the Danish CMM Club, a users’ group regarding CMMs that has existed in Denmark since 1994. The Danish CMM Club was founded by the Department of Manufacturing Engineering...... termination of the second lifetime cycle of the club. This conference treates the traceability of geometrical measurements with particular reference to those obtained using coordinate measuring machines. A number of on-going activities and new achievements in coordinate metrology are presented by European...

  13. Distributed Coordination of Household Electricity Consumption

    DEFF Research Database (Denmark)

    Juelsgaard, Morten; Teixeira, Andre; Johansson, Mikael

    2014-01-01

    This work presents a distributed framework for coordination of flexible electricity consumption for a number of households in the distribution grid. We conduct coordination with the purpose of minimizing a trade-off between individual concerns about discomfort and electricity cost, on the one hand......, and joint concerns about grid losses and voltage variations on the other. Our contribution is mainly to illustrate how to conduct distributed coordination when consumers are jointly coupled by grid losses and voltage variations. In addition we illustrate the benefit of including consumption management...... in the grid operation, and how different types of consumption may present various benefits....

  14. Coordination and Convening of the 2016 Arctic Science Summit Week

    Energy Technology Data Exchange (ETDEWEB)

    Hinzman, Larry D. [Univ. of Alaska, Fairbanks, AK (United States)

    2016-11-13

    The Arctic Science Summit Week, Arctic Observing Summit, Arctic Council Senior Arctic Officials, Model Arctic Council, and International Arctic Assembly were convened on the campus of the University of Alaska Fairbanks with great productivity and satisfaction of the participants. We were pleased to welcome over 1000 participants from 30 different nations and over 130 different institutions. The organization and execution of these meetings was extensive and complex involving more than 250 coordinators, volunteers and contributors from across Alaska. The participants were enthusiastic in their praise of the content and accomplishments of the meeting, but they were equally happy about the genuine welcome offered to our guests by the people of Alaska. Hosting a complex event such as this summit required an army of supporting services and we were blessed to have volunteers from Fairbanks, North Pole, Anchorage and other communities throughout Alaska helping us meet these needs. This truly was an event hosted by the people of Alaska. The significance of these events cannot be overstated. The US and global communities are finally coming to the realization of the important role that the Arctic plays in international politics, economics, and science. The Arctic has experienced tremendous changes in recent years, offering new opportunities that may be addressed through international collaborations, and serious challenges that must be addressed through active investment, adaptation and national and international coordination. Over 10% of the meeting participants were indigenous peoples, from indigenous organizations or hailed from small remote communities. This is still lower than we had hoped, but it is greater participation than similar meetings have experienced in the past. It is through such engagement that we can attack problems related to the changing environment, stagnant economies, and social ills.

  15. Auditory perception and the control of spatially coordinated action of deaf and hearing children.

    Science.gov (United States)

    Savelsbergh, G J; Netelenbos, J B; Whiting, H T

    1991-03-01

    From birth onwards, auditory stimulation directs and intensifies visual orientation behaviour. In deaf children, by definition, auditory perception cannot take place and cannot, therefore, make a contribution to visual orientation to objects approaching from outside the initial field of view. In experiment 1, a difference in catching ability is demonstrated between deaf and hearing children (10-13 years of age) when the ball approached from the periphery or from outside the field of view. No differences in catching ability between the two groups occurred when the ball approached from within the field of view. A second experiment was conducted in order to determine if differences in catching ability between deaf and hearing children could be attributed to execution of slow orientating movements and/or slow reaction time as a result of the auditory loss. The deaf children showed slower reaction times. No differences were found in movement times between deaf and hearing children. Overall, the findings suggest that a lack of auditory stimulation during development can lead to deficiencies in the coordination of actions such as catching which are both spatially and temporally constrained.

  16. Coordinated Control of Three-Dimensional Components of Smooth Pursuit to Rotating and Translating Textures.

    Science.gov (United States)

    Edinger, Janick; Pai, Dinesh K; Spering, Miriam

    2017-01-01

    The neural control of pursuit eye movements to visual textures that simultaneously translate and rotate has largely been neglected. Here we propose that pursuit of such targets-texture pursuit-is a fully three-dimensional task that utilizes all three degrees of freedom of the eye, including torsion. Head-fixed healthy human adults (n = 8) tracked a translating and rotating random dot pattern, shown on a computer monitor, with their eyes. Horizontal, vertical, and torsional eye positions were recorded with a head-mounted eye tracker. The torsional component of pursuit is a function of the rotation of the texture, aligned with its visual properties. We observed distinct behaviors between those trials in which stimulus rotation was in the same direction as that of a rolling ball ("natural") in comparison to those with the opposite rotation ("unnatural"): Natural rotation enhanced and unnatural rotation reversed torsional velocity during pursuit, as compared to torsion triggered by a nonrotating random dot pattern. Natural rotation also triggered pursuit with a higher horizontal velocity gain and fewer and smaller corrective saccades. Furthermore, we show that horizontal corrective saccades are synchronized with torsional corrective saccades, indicating temporal coupling of horizontal and torsional saccade control. Pursuit eye movements have a torsional component that depends on the visual stimulus. Horizontal and torsional eye movements are separated in the motor periphery. Our findings suggest that translational and rotational motion signals might be coordinated in descending pursuit pathways.

  17. Co-ordinated action between youth-care and sports: facilitators and barriers.

    Science.gov (United States)

    Hermens, Niels; de Langen, Lisanne; Verkooijen, Kirsten T; Koelen, Maria A

    2017-07-01

    In the Netherlands, youth-care organisations and community sports clubs are collaborating to increase socially vulnerable youths' participation in sport. This is rooted in the idea that sports clubs are settings for youth development. As not much is known about co-ordinated action involving professional care organisations and community sports clubs, this study aims to generate insight into facilitators of and barriers to successful co-ordinated action between these two organisations. A cross-sectional study was conducted using in-depth semi-structured qualitative interview data. In total, 23 interviews were held at five locations where co-ordinated action between youth-care and sports takes place. Interviewees were youth-care workers, representatives from community sports clubs, and Care Sport Connectors who were assigned to encourage and manage the co-ordinated action. Using inductive coding procedures, this study shows that existing and good relationships, a boundary spanner, care workers' attitudes, knowledge and competences of the participants, organisational policies and ambitions, and some elements external to the co-ordinated action were reported to be facilitators or barriers. In addition, the participants reported that the different facilitators and barriers influenced the success of the co-ordinated action at different stages of the co-ordinated action. Future research is recommended to further explore the role of boundary spanners in co-ordinated action involving social care organisations and community sports clubs, and to identify what external elements (e.g. events, processes, national policies) are turning points in the formation, implementation and continuation of such co-ordinated action. © 2017 John Wiley & Sons Ltd.

  18. Le elasticità del commercio internazionale nei modelli " centro-periferia" di crescita e sviluppo. (Foreign trade elasticities in centre-periphery models of growth and development

    Directory of Open Access Journals (Sweden)

    A.P. THIRLWALL

    2013-12-01

    Full Text Available L'autore esamina la differenza nei tassi di crescita tra i paesi e sostiene che essi possono essere ricondotti alla forza della bilancia dei pagamenti , determinata in gran parte dalla propensione all'export rispetto alla propensione a importare. Performance di crescita relativa , quindi , puossono essere compresi , cercando elasticità al reddito della domanda per le esportazioni e le importazioni . Questa intuizione nel processo di determinazione del reddito in economie aperte , disponibili a Harrod così come nella letteratura sullo sviluppo economico , si sviluppa attraverso i cosiddetti modelli centro-periferia di crescita e sviluppo . Tuttavia , le loro conclusioni essenziali sono state già contenute nei primi articoli classici . L'autore si concentra su tre di essi ( Prebisch , Veggenti , Kaldor per sostenere che di un paese a tasso di crescita relativo  quella di un altro può essere approssimata dal rapporto tra la sua elasticità al reddito della domanda per le esportazioni verso la sua elasticità al reddito della domanda di importazioni.The Author looks at the difference in growth rates among countries and argues that they can be traced to the strength of the balance of payments position, determined largely by the propensity to export relative to the propensity to import. Relative growth performance, thus, can be understood by looking to income elasticities of demand for exports and imports. This insight into the process of income determination in open economies, found in Harrod as well as in the literature on economic development, is developed through so-called centre-periphery models of growth and development. However, their essential conclusions were already contained in the early classic papers. The author concentrates on three of them (Prebisch, Seers, Kaldor to argue that a country’s growth rate relative to another’s can be approximated by the ratio of its income elasticity of demand for exports to its income elasticity

  19. Superfield extended BRST quantization in general coordinates

    OpenAIRE

    Geyer, B.; Gitman, D. M.; Lavrov, P. M.; Moshin, P. Yu.

    2003-01-01

    We propose a superfield formalism of Lagrangian BRST-antiBRST quantization of arbitrary gauge theories in general coordinates with the base manifold of fields and antifields desribed in terms of both bosonic and fermionic variables.

  20. Modeling, Control and Coordination of Helicopter Systems

    CERN Document Server

    Ren, Beibei; Chen, Chang; Fua, Cheng-Heng; Lee, Tong Heng

    2012-01-01

    Modeling, Control and Coordination of Helicopter Systems provides a comprehensive treatment of helicopter systems, ranging from related nonlinear flight dynamic modeling and stability analysis to advanced control design for single helicopter systems, and also covers issues related to the coordination and formation control of multiple helicopter systems to achieve high performance tasks. Ensuring stability in helicopter flight is a challenging problem for nonlinear control design and development. This book is a valuable reference on modeling, control and coordination of helicopter systems,providing readers with practical solutions for the problems that still plague helicopter system design and implementation. Readers will gain a complete picture of helicopters at the systems level, as well as a better understanding of the technical intricacies involved. This book also: Presents a complete picture of modeling, control and coordination for helicopter systems Provides a modeling platform for a general class of ro...

  1. Axisymmetric magnetohydrodynamic equilibria in local polar coordinates

    International Nuclear Information System (INIS)

    Clemente, R.A.

    1982-01-01

    The Grad--Shafranov equation for an ideal magnetohydrodynamic axisymmetric toroidal configuration is solved analytically in a local polar coordinate system using a novel method which produces solutions valid up to the second order in the inverse aspect ratio expansion

  2. Selective Placement Program Coordinator (SPPC) Directory

    Data.gov (United States)

    Office of Personnel Management — List of the Selective Placement Program Coordinators (SPPC) in Federal agencies, updated as needed. Users can filter the list by choosing a state and/or agency name.

  3. Unraveling interlimb interactions underlying bimanual coordination

    NARCIS (Netherlands)

    Ridderikhoff, A.; Daffertshofer, A.; Peper, C.E.; Beek, P.J.

    2005-01-01

    Three sources of interlimb interactions have been postulated to underlie the stability characteristics of bimanual coordination but have never been evaluated in conjunction: integrated timing of feedforward control signals, phase entrainment by contralateral afference, and timing corrections based

  4. The Schwarzschild metric: It's the coordinates, stupid!

    Science.gov (United States)

    Fromholz, Pierre; Poisson, Eric; Will, Clifford M.

    2014-04-01

    Every general relativity textbook emphasizes that coordinates have no physical meaning. Nevertheless, a coordinate choice must be made in order to carry out real calculations, and that choice can make the difference between a calculation that is simple and one that is a mess. We give a concrete illustration of the maxim that "coordinates matter" using the exact Schwarzschild solution for a vacuum, static spherical spacetime. We review the standard textbook derivation, Schwarzschild's original 1916 derivation, and a derivation using the Landau-Lifshitz formulation of the Einstein field equations. The last derivation is much more complicated, has one aspect for which we have been unable to find a solution, and gives an explicit illustration of the fact that the Schwarzschild geometry can be described in infinitely many coordinate systems.

  5. HYbrid Coordinate Ocean Model (HYCOM): Global

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Global HYbrid Coordinate Ocean Model (HYCOM) and U.S. Navy Coupled Ocean Data Assimilation (NCODA) 3-day, daily forecast at approximately 9-km (1/12-degree)...

  6. Human Resources Coordinator | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Human Resources Coordinator supports the HR Business Partner in the delivery of ... of various reports for HR Business Partners and HR management. ... services and information to candidates applying on job openings in IDRC, ...

  7. Coordination in Categorical Compositional Distributional Semantics

    Directory of Open Access Journals (Sweden)

    Dimitri Kartsaklis

    2016-08-01

    Full Text Available An open problem with categorical compositional distributional semantics is the representation of words that are considered semantically vacuous from a distributional perspective, such as determiners, prepositions, relative pronouns or coordinators. This paper deals with the topic of coordination between identical syntactic types, which accounts for the majority of coordination cases in language. By exploiting the compact closed structure of the underlying category and Frobenius operators canonically induced over the fixed basis of finite-dimensional vector spaces, we provide a morphism as representation of a coordinator tensor, and we show how it lifts from atomic types to compound types. Linguistic intuitions are provided, and the importance of the Frobenius operators as an addition to the compact closed setting with regard to language is discussed.

  8. Coordination Approaches for Complex Software Systems

    NARCIS (Netherlands)

    Bosse, T.; Hoogendoorn, M.; Treur, J.

    2006-01-01

    This document presents the results of a collaboration between the Vrije Universiteit Amsterdam, Department of Artificial Intelligence and Force Vision to investigate coordination approaches for complex software systems. The project was funded by Force Vision.

  9. Coordination Polymer Gels by Electron Beam

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ji Ha; Cho, Young Je; Jung, Jong Hwa [Gyeongsang National Univ., Jinju (Korea, Republic of)

    2011-07-01

    Hydrogenation of a pyridine derivative possessing tetrazole moieties as end groups, without long alkyl chain groups, results in the formation of a Mg(NO{sub 3}){sub 2} coordination polymer gel. The polymer exhibits a strong fluorescence enhancement upon gel formation. 1 can also be gloated with a variety of magnesium anions such as SO{sub 4}{sup 2-}, NO{sub 3}{sup -}, Cl{sup -}, Br{sup -} and I{sup -}, indicating that the coordination polymer gel formation of 1 does not strongly depends on anions. The Seam and ABM images of Mg{sup 2+} coordination polymer gel 1 display a flabbier network with several micrometers long, widths in the range 60-70 nm and thicknesses of about 3 nm. In addition, photophysical studies show that the hydrogel exhibits a typical {pi}-{pi} transition and gives rise to high fluorescence behavior. The coordination polymer hydrogel exhibits viscoelastic behavior as evidenced from the rheological studies.

  10. Coordinating Transit Transfers in Real Time

    Science.gov (United States)

    2016-05-06

    Transfers are a major source of travel time variability for transit passengers. Coordinating transfers between transit routes in real time can reduce passenger waiting times and travel time variability, but these benefits need to be contrasted with t...

  11. Junior Information and Records Coordinator | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Information and Records Operations (IRO) Program Support ... Coordinator to support him/her performing day to day business assigned to this position. ... Digitization and digital assets management are main tasks to guarantee that digital ...

  12. Process Coordination and Policy Officer | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Such liaison aims to ensure that the operational aspects and requirements are taken into account. ... Business Process Coordination and Change Management ... Liaises with the Resources Planning and Development Officer of the Office of ...

  13. Desynchronizing electrical and sensory coordinated reset neuromodulation

    OpenAIRE

    Popovych, Oleksandr V.; Tass, Peter A.

    2012-01-01

    Coordinated reset (CR) stimulation is a desynchronizing stimulation technique based on timely coordinated phase resets of sub-populations of a synchronized neuronal ensemble. It has initially been computationally developed for electrical deep brain stimulation (DBS), to enable an effective desynchronization and unlearning of pathological synchrony and connectivity (anti-kindling). Here we computationally show for ensembles of spiking and bursting model neurons interacting via excitatory and i...

  14. Desynchronizing Electrical and Sensory Coordinated Reset Neuromodulation

    OpenAIRE

    Oleksandr V. Popovych; Peter A. Tass; Peter A. Tass

    2012-01-01

    Coordinated reset (CR) stimulation is a desynchronizing stimulation technique based on timely coordinated phase resets of sub-populations of a synchronized neuronal ensemble. It has initially been computationally developed for electrical deep brain stimulation (DBS),to enable an effective desynchronization and unlearning of pathological synchrony and connectivity (anti-kindling). Here we computationally show for ensembles of spiking and bursting model neurons interacting via excitatory and in...

  15. Collaborative Supply Chain Planning and Coordination

    DEFF Research Database (Denmark)

    Wong, Chee Yew

    products, differentiating retailers, accurate response (with forecast adjustment and premature replenishment), quick response (order-penetration-point relocation and lead-time reduction). These analyses extend the Fisher Model of responsiveness and refine six propositions or principles of responsiveness...... processes, particularly the behaviour of risk-taking/avoidance, conflict resolutions, and self-interest. All these lead to conclusion of five propositions or principles of supply chain coordination, and the theory of coordination process and behaviour. Combining the propositions of responsiveness...

  16. Trends in coordination and transmission service

    International Nuclear Information System (INIS)

    Anon.

    1991-01-01

    Investor-owned utilities increasingly are taking significant advantage of the benefits available from coordination transactions and transmission service. This chapter describes Edison Electric Institute (EEI's) estimate as to the growth in sales-for-resale (including coordination service) over the past two decades. With respect to transmission service, this chapter describes the significant growth in both the level of transmission service and the number of transmission agreements

  17. Co-ordinating Product Developing Activities

    DEFF Research Database (Denmark)

    Terkelsen, Søren Bendix

    1996-01-01

    The paper contains a presentation of research methods to be used in case studies in product development and a presentation on how to deal with Design Co-ordination according to litterature......The paper contains a presentation of research methods to be used in case studies in product development and a presentation on how to deal with Design Co-ordination according to litterature...

  18. Traceability and uncertainty estimation in coordinate metrology

    DEFF Research Database (Denmark)

    Hansen, Hans Nørgaard; Savio, Enrico; De Chiffre, Leonardo

    2001-01-01

    National and international standards have defined performance verification procedures for coordinate measuring machines (CMMs) that typically involve their ability to measure calibrated lengths and to a certain extent form. It is recognised that, without further analysis or testing, these results...... are required. Depending on the requirements for uncertainty level, different approaches may be adopted to achieve traceability. Especially in the case of complex measurement situations and workpieces the procedures are not trivial. This paper discusses the establishment of traceability in coordinate metrology...

  19. Control Coordination of Large Scale Hereditary Systems.

    Science.gov (United States)

    1985-07-01

    Theory - A Hilbert Space Approach, (Academic Press, New York, 1982). [4] W. Findeisen , F. N. Bailey, M. Brdys, K Malinowski, P. Tatjewski and A. Wozniak... Findeisen et al. (1980), in the sense that local models are used in the design of component control laws and a higher level coordination problem is...Vol. 1, pp. 590-591, 1985. 3. W. Findeisen , F.N. Bailley, M. Brdys, K. Malinowski, P. Tatjewski and A. Wozniak, Control Coordination in Hierarchical

  20. Event shape sorting

    International Nuclear Information System (INIS)

    Kopecna, Renata; Tomasik, Boris

    2016-01-01

    We propose a novel method for sorting events of multiparticle production according to the azimuthal anisotropy of their momentum distribution. Although the method is quite general, we advocate its use in analysis of ultra-relativistic heavy-ion collisions where a large number of hadrons is produced. The advantage of our method is that it can automatically sort out samples of events with histograms that indicate similar distributions of hadrons. It takes into account the whole measured histograms with all orders of anisotropy instead of a specific observable (e.g., v 2 , v 3 , q 2 ). It can be used for more exclusive experimental studies of flow anisotropies which are then more easily compared to theoretical calculations. It may also be useful in the construction of mixed-events background for correlation studies as it allows to select events with similar momentum distribution. (orig.)

  1. "Universe" event at AIMS

    Science.gov (United States)

    2008-06-01

    Report of event of 11 May 2008 held at the African Institute of Mathematical Sciences (Muizenberg, Cape), with speakers Michael Griffin (Administrator of NASA), Stephen Hawking (Cambridge), David Gross (Kavli Institute, Santa Barbara) and George Smoot (Berkeley).

  2. Event visualization in ATLAS

    CERN Document Server

    AUTHOR|(INSPIRE)INSPIRE-00211497; The ATLAS collaboration; Boudreau, Joseph; Konstantinidis, Nikolaos; Martyniuk, Alex; Moyse, Edward; Thomas, Juergen; Waugh, Ben; Yallup, David

    2017-01-01

    At the beginning, HEP experiments made use of photographical images both to record and store experimental data and to illustrate their findings. Then the experiments evolved and needed to find ways to visualize their data. With the availability of computer graphics, software packages to display event data and the detector geometry started to be developed. Here, an overview of the usage of event display tools in HEP is presented. Then the case of the ATLAS experiment is considered in more detail and two widely used event display packages are presented, Atlantis and VP1, focusing on the software technologies they employ, as well as their strengths, differences and their usage in the experiment: from physics analysis to detector development, and from online monitoring to outreach and communication. Towards the end, the other ATLAS visualization tools will be briefly presented as well. Future development plans and improvements in the ATLAS event display packages will also be discussed.

  3. Analysis of extreme events

    CSIR Research Space (South Africa)

    Khuluse, S

    2009-04-01

    Full Text Available ) determination of the distribution of the damage and (iii) preparation of products that enable prediction of future risk events. The methodology provided by extreme value theory can also be a powerful tool in risk analysis...

  4. RAS Initiative - Events

    Science.gov (United States)

    The NCI RAS Initiative has organized multiple events with outside experts to discuss how the latest scientific and technological breakthroughs can be applied to discover vulnerabilities in RAS-driven cancers.

  5. Coordinated supply chain dynamic production planning model

    Science.gov (United States)

    Chandra, Charu; Grabis, Janis

    2001-10-01

    Coordination of different and often contradicting interests of individual supply chain members is one of the important issues in supply chain management because the individual members can not succeed without success of the supply chain and vice versa. This paper investigates a supply chain dynamic production planning problem with emphasis on coordination. A planning problem is formally described using a supply chain kernel, which defines supply chain configuration, management policies, available resources and objectives both at supply chain or macro and supply chain member or micro levels. The coordinated model is solved in order to balance decisions made at the macro and micro levels and members' profitability is used as the coordination criterion. The coordinated model is used to determine inventory levels and production capacity across the supply chain. Application of the coordinated model distributes costs burden uniformly among supply chain members and preserves overall efficiency of the supply chain. Influence of the demand series uncertainty is investigated. The production planning model is a part of the integrated supply chain decision modeling system, which is shared among the supply chain members across the Internet.

  6. Gargamelle: neutral current event

    CERN Multimedia

    1973-01-01

    This event shows real tracks of particles from the 1200 litre Gargamelle bubble chamber that ran on the PS from 1970 to 1976 and on the SPS from 1976 to 1979. In this image a neutrino passes close to a nucleon and reemerges as a neutrino. Such events are called neutral curent, as they are mediated by the Z0 boson which has no electric charge.

  7. Small Business Procurement Event

    Science.gov (United States)

    2014-08-13

    Small Business Procurement Event 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK...NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Department of the Navy,Office of Small Business Programs,720 Kennon...distribution unlimited 13. SUPPLEMENTARY NOTES NDIA 27th Navy Gold Coast Small Business Procurement Event, 12-13 Aug 2014, San Diego, CA. 14. ABSTRACT

  8. The ALEPH event builder

    International Nuclear Information System (INIS)

    Benetta, R.; Marchioro, A.; McPherson, G.; Rueden, W. von

    1986-01-01

    The data acquisition system for the ALEPH experiment at CERN is organised in a hierarchical fashion within FASTBUS. The detector consists of a number of sub-detectors whose data must be individually assembled and formatted in real time. This task of 'event building' will be performed by a FASTBUS module in which a powerful microprocessor running high level software is embedded. Such a module, called an Event Builder, has been constructed by the ALEPH Online Group at CERN. (Auth.)

  9. Hawking effect and quantum nonthermal radiation of an arbitrarily accelerating charged black hole using a new tortoise coordinate transformation

    International Nuclear Information System (INIS)

    Pan Wei-Zhen; Yang Xue-Jun; Xie Zhi-Kun

    2011-01-01

    Using a new tortoise coordinate transformation, this paper investigates the Hawking effect from an arbitrarily accelerating charged black hole by the improved Damour—Ruffini method. After the tortoise coordinate transformation, the Klein—Gordon equation can be written as the standard form at the event horizon. Then extending the outgoing wave from outside to inside of the horizon analytically, the surface gravity and Hawking temperature can be obtained automatically. It is found that the Hawking temperatures of different points on the surface are different. The quantum nonthermal radiation characteristics of a black hole near the event horizon is also discussed by studying the Hamilton—Jacobi equation in curved spacetime and the maximum overlap of the positive and negative energy levels near the event horizon is given. There is a dimensional problem in the standard tortoise coordinate and the present results may be more reasonable. (geophysics, astronomy, and astrophysics)

  10. An adaptive control strategy of converter based DG to maintain protection coordination in distribution system

    DEFF Research Database (Denmark)

    Su, Chi; Liu, Zhou; Chen, Zhe

    2014-01-01

    of network protection devices. As a protection measure commonly used in distribution network, recloser-fuse coordination could suffer from this impact. Research work has been conducted to deal with this problem by modifying the control strategy of the DG converters during faults. These solutions generally...... reduce the current output from the converters during faults so as to mitigate the influence on protection coordination. However, converter current reduction may not be necessary for all types of faults. This paper proposes a converter control strategy with adaptivity to different fault types and also non......-fault voltage drop events. This control strategy is validated by simulations in DIgSILENT PowerFactory....

  11. Predicting the 4th caustic crossing in Gaia16aye binary microlensing event

    Science.gov (United States)

    Mroz, P.; Wyrzykowski, L.; Rybicki, K.; Altavilla, G.; Bakis, V.; Bendjoya, P.; Birenbaum, G.; Blagorodnova, N.; Blanco-Cuaresma, S.; Bonanos, A.; Bozza, V.; Britavskiy, N.; Burgaz, U.; Butterley, T.; Capuozzo, P.; Carrasco, J. M.; Chruslinska, M.; Damljanovic, G.; Dennefeld, M.; Dhillon, V. S.; Dominik, M.; Esenoglu, H.; Fossey, S.; Gomboc, A.; Hallokoun, N.; Hamanowicz, A.; Hardy, L. K.; Hudec, R.; Khamitov, I.; Klencki, J.; Kolaczkowski, Z.; Kolb, U.; Leonini, S.; Leto, G.; Lewis, F.; Liakos, A.; Littlefair, S. P.; Maoz, D.; Maund, J. R.; Mikolajczyk, P.; Palaversa, L.; Pawlak, M.; Penny, M.; Piascik, A.; Reig, P.; Rhodes, L.; Russell, D.; Sanchez, R. Z.; Shappee, B.; Shvartzvald, Y.; Sitek, M.; Sniegowska, M.; Sokolovsky, K.; Steele, I.; Street, R.; Tomasella, L.; Trascinelli, L.; Wiersema, K.; Wilson, R. W.; Zharkov, I.; Zola, S.; Zubareva, A.

    2016-11-01

    Gaia16aye, nicknamed Ayers Rock (19:40:01.13 +30:07:53.4, J2000) is a spectacular binary microlensing event in the Northern Galactic Plane. The event has been observed by Gaia, ASAS-SN survey and a network of follow-up telescopes, coordinated by the Time Domain WP of the EC's OPTICON grant.

  12. Improving the Teaching of Discrete-Event Control Systems Using a LEGO Manufacturing Prototype

    Science.gov (United States)

    Sanchez, A.; Bucio, J.

    2012-01-01

    This paper discusses the usefulness of employing LEGO as a teaching-learning aid in a post-graduate-level first course on the control of discrete-event systems (DESs). The final assignment of the course is presented, which asks students to design and implement a modular hierarchical discrete-event supervisor for the coordination layer of a…

  13. Information Systems Coordinate Emergency Management

    Science.gov (United States)

    2012-01-01

    -changing planet. This information can be captured, analyzed, and visualized by geographic information systems (GIS) to produce maps, charts, and other tools that can reveal information essential to a wide variety of applications including emergency management. Knowing precise, real-time information about the size, location, environmental conditions, and resulting damage of an event like a flood or wildfire as well as the location and numbers of emergency responders and other resources contributes directly to the effectiveness of disaster mitigation. The need for such information is also evident when responding to homeland security threats, such as a terrorist attack. Recognizing the value of its geospatial information resources for this and other purposes, in 1998 Stennis and the state of Mississippi partnered to form what became the Enterprise for Innovative Geospatial Solutions (EIGS) industry cluster, supporting the growth of remote sensing and GIS-based research and business. As part of EIGS, several companies partnered with NASA through dual use and Small Business Innovation Research (SBIR) contracts. Among those was NVision.

  14. Unified patterns to transform business rules into an event coordination mechanism

    OpenAIRE

    De Roover, Willem; Vanthienen, Jan

    2011-01-01

    Business rules define and constrain various aspects of the business, such as vocabulary, behavior and organizational issues. Enforcing the rules of the business in information systems is however not straightforward, because different mechanisms exist for the (semi-)automatic transformation of various business constraints and rules. In this paper, we examine if and how business rules, not only data rules, but also process rules, timing rules, authorization rules, etc., can be expressed i...

  15. Coordinated Cluster/Double Star observations of dayside flux transfer events on 6 April 2004

    Science.gov (United States)

    Wang, Jue; Pu, ZuYin; Zhou, XuZhi; Zhang, XianGuo; Dunlop, Malcolm; Fu, SuiYan; Xie, Lun; Zong, QiuGang; Xiao, ChiJie; Wang, XiaoGang; Liu, ZhenXing

    2008-10-01

    With the Double Star Program TC1 in the equatorial orbit and Cluster tetrahedron in the high latitude polar orbit, a conjunct observation of FTEs on the dayside magnetopause (MP) on April 6, 2004 is presented in this study. The FTEs observed by TC1 at low latitudes are characterized to be generated in the subsolar region and the obtained flux tube axes orientate along the predicted low latitude component magnetic reconnection X-line, indicating that these FTEs were more likely to be generated through multiple X-line reconnection or single X-line bursty reconnection. During the same period, Cluster also encountered a series of magnetosheath FTEs with their axes pointing roughly along the interplanetary magnetic field. At last, the global FTE configuration is obtained from observations in different locations, which is in good agreement with the "elbow shape" model.

  16. Postural Coordination during Socio-motor Improvisation.

    Science.gov (United States)

    Gueugnon, Mathieu; Salesse, Robin N; Coste, Alexandre; Zhao, Zhong; Bardy, Benoît G; Marin, Ludovic

    2016-01-01

    Human interaction often relies on socio-motor improvisation. Creating unprepared movements during social interaction is not a random process but relies on rules of synchronization. These situations do not only involve people to be coordinated, but also require the adjustment of their posture in order to maintain balance and support movements. The present study investigated posture in such a context. More precisely, we first evaluated the impact of amplitude and complexity of arm movements on posture in solo situation. Then, we assessed the impact of interpersonal coordination on posture using the mirror game in which dyads performed improvised and synchronized movements (i.e., duo situation). Posture was measured through ankle-hip coordination in medio-lateral and antero-posterior directions (ML and AP respectively). Our results revealed the spontaneous emergence of in-phase pattern in ML direction and antiphase pattern in AP direction for solo and duo situations. These two patterns respectively refer to the simultaneous flexion/extension of the ankles and the hips in the same or opposite direction. It suggests different functional roles of postural coordination patterns in each direction, with in-phase supporting task performance in ML (dynamical stability) and antiphase supporting postural control in AP (mechanical stability). Although amplitude of movement did not influence posture, movement complexity disturbed postural stability in both directions. Conversely, interpersonal coordination promoted postural stability in ML but not in AP direction. These results are discussed in terms of the difference in coupling strength between ankle-hip coordination and interpersonal coordination.

  17. Postural coordination during socio-motor improvisation

    Directory of Open Access Journals (Sweden)

    Mathieu Gueugnon

    2016-08-01

    Full Text Available Human interaction often relies on socio-motor improvisation. Creating unprepared movements during social interaction is not a random process but relies on rules of synchronization. These situations do not only involve people to be coordinated, but also require the adjustment of their posture in order to maintain balance and support movements. The present study investigated posture in such a context. More precisely, we first evaluated the impact of amplitude and complexity of arm movements on posture in solo situation. Then, we assessed the impact of interpersonal coordination on posture using the mirror game in which dyads performed improvised and synchronized movements (i.e., duo situation. Posture was measured through ankle-hip coordination in medio-lateral and antero-posterior directions (ML and AP respectively. Our results revealed the spontaneous emergence of in-phase pattern in ML direction and anti-phase pattern in AP direction for solo and duo situations. These two patterns respectively refer to the simultaneous flexion/extension of the ankles and the hips in the same or opposite direction. It suggests different functional roles of postural coordination patterns in each direction, with in-phase supporting task performance in ML (dynamical stability and antiphase supporting postural control in AP (mechanical stability. Although amplitude of movement did not influence posture, movement complexity disturbed postural stability in both directions. Conversely, interpersonal coordination promoted postural stability in ML but not in AP direction. These results are discussed in terms of the difference in coupling strength between ankle-hip coordination and interpersonal coordination.

  18. RETRIEVAL EVENTS EVALUATION

    International Nuclear Information System (INIS)

    Wilson, T.

    1999-01-01

    The purpose of this analysis is to evaluate impacts to the retrieval concept presented in the Design Analysis ''Retrieval Equipment and Strategy'' (Reference 6), from abnormal events based on Design Basis Events (DBE) and Beyond Design Basis Events (BDBE) as defined in two recent analyses: (1) DBE/Scenario Analysis for Preclosure Repository Subsurface Facilities (Reference 4); and (2) Preliminary Preclosure Design Basis Event Calculations for the Monitored Geologic Repository (Reference 5) The objective of this task is to determine what impacts the DBEs and BDBEs have on the equipment developed for retrieval. The analysis lists potential impacts and recommends changes to be analyzed in subsequent design analyses for developed equipment, or recommend where additional equipment may be needed, to allow retrieval to be performed in all DBE or BDBE situations. This analysis supports License Application design and therefore complies with the requirements of Systems Description Document input criteria comparison as presented in Section 7, Conclusions. In addition, the analysis discusses the impacts associated with not using concrete inverts in the emplacement drifts. The ''Retrieval Equipment and Strategy'' analysis was based on a concrete invert configuration in the emplacement drift. The scope of the analysis, as presented in ''Development Plan for Retrieval Events Evaluation'' (Reference 3) includes evaluation and criteria of the following: Impacts to retrieval from the emplacement drift based on DBE/BDBEs, and changes to the invert configuration for the preclosure period. Impacts to retrieval from the main drifts based on DBE/BDBEs for the preclosure period

  19. Revisiting event horizon finders

    International Nuclear Information System (INIS)

    Cohen, Michael I; Pfeiffer, Harald P; Scheel, Mark A

    2009-01-01

    Event horizons are the defining physical features of black hole spacetimes, and are of considerable interest in studying black hole dynamics. Here, we reconsider three techniques to find event horizons in numerical spacetimes: integrating geodesics, integrating a surface, and integrating a level-set of surfaces over a volume. We implement the first two techniques and find that straightforward integration of geodesics backward in time is most robust. We find that the exponential rate of approach of a null surface towards the event horizon of a spinning black hole equals the surface gravity of the black hole. In head-on mergers we are able to track quasi-normal ringing of the merged black hole through seven oscillations, covering a dynamic range of about 10 5 . Both at late times (when the final black hole has settled down) and at early times (before the merger), the apparent horizon is found to be an excellent approximation of the event horizon. In the head-on binary black hole merger, only some of the future null generators of the horizon are found to start from past null infinity; the others approach the event horizons of the individual black holes at times far before merger.

  20. Adaptation of coordination mechanisms to network structures

    Directory of Open Access Journals (Sweden)

    Herwig Mittermayer

    2008-12-01

    Full Text Available The coordination efficiency of Supply Chain Management is determined by two opposite poles: benefit from improved planning results and associated coordination cost. The centralization grade, applied coordination mechanisms and IT support have influence on both categories. Therefore three reference types are developed and subsequently detailed in business process models for different network structures. In a simulation study the performance of these organization forms are compared in a process plant network. Coordination benefit is observed if the planning mode is altered by means of a demand planning IT tool. Coordination cost is divided into structural and activity-dependent cost. The activity level rises when reactive planning iterations become necessary as a consequence of inconsistencies among planning levels. Some characteristic influence factors are considered to be a reason for uninfeasible planning. In this study the effect of capacity availability and stochastic machine downtimes is investigated in an uncertain demand situation. Results that if the network runs with high overcapacity, central planning is less likely to increase benefit enough to outweigh associated cost. Otherwise, if capacity constraints are crucial, a central planning mode is recommendable. When also unforeseen machine downtimes are low, the use of sophisticated IT tools is most profitable.

  1. Coordination and standardization of federal sedimentation activities

    Science.gov (United States)

    Glysson, G. Douglas; Gray, John R.

    1997-01-01

    In August 1964, the Bureau of the Budget issued Circular A-67 to set forth guidelines for the coordination of water-data acquisition activities throughout the Federal government. The U.S. Department of the Interior was assigned the task of implementing Circular A-67, which in turn redelegated this responsibility to the U.S. Geological Survey (USGS). Delegation of the lead responsibility for water-data coordination to the USGS occurred because of its historical role as the primary agency for water-data acquisition in the United States. To provide overall leadership for implementing the provisions of Circular A-67, the USGS established the Office of Water Data Coordination in the Water Resources Division (WRD). In addition, regional and district offices of the WRD were delegated responsibility for coordinating water data within their geographic areas of responsibility. On December 10, 1991, the Office of Management and Budget issued OMB Number Memorandum M-92-01, which expands the USGS's coordination role to encompass all water information. This includes data critical to water resources in the following categories: - surface- and ground-water quality and quantity,

  2. Reporting of safeguards events

    International Nuclear Information System (INIS)

    Dwyer, P.A.; Ervin, N.E.

    1988-02-01

    On June 9, 1987, the Commission published in the Federal Register a final rule revising the reporting requirements for safeguards events. Safeguards events include actual or attempted theft of special nuclear material (SNM); actual or attempted acts or events which interrupt normal operations at power reactors due to unauthorized use of or tampering with machinery, components, or controls; certain threats made against facilities possessing SNM; and safeguards system failures impacting the effectiveness of the system. The revised rule was effective October 8, 1987. On September 14, 1987, the NRC held a workshop in Bethesda, MD, to answer affected licensees' questions on the final rule. This report documents questions discussed at the September 14 meeting, reflects a completed staff review of the answers, and supersedes previous oral comment on the topics covered

  3. Discrete-Event Simulation

    Directory of Open Access Journals (Sweden)

    Prateek Sharma

    2015-04-01

    Full Text Available Abstract Simulation can be regarded as the emulation of the behavior of a real-world system over an interval of time. The process of simulation relies upon the generation of the history of a system and then analyzing that history to predict the outcome and improve the working of real systems. Simulations can be of various kinds but the topic of interest here is one of the most important kind of simulation which is Discrete-Event Simulation which models the system as a discrete sequence of events in time. So this paper aims at introducing about Discrete-Event Simulation and analyzing how it is beneficial to the real world systems.

  4. First Indico Virtual Event

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    The first Indico virtual event will take place on February 4th 15:00 and will focus on two main topics The release of Indico v1.2 The migration of the OO Indico backend database (ZODB) to a more standard DBMS It will be fully virtual using the CERN Vidyo service and will foster discussions between developers and administrators of Indico servers worldwide. Connections to the virtual room will be open, but attendees are encouraged to register to the event, in order to be informed of any changes in the organisation if any. If you would like to add a topic of discussion or propose yourself a contribution, please let us know at indico-team@cern.ch. Connection to Vidyo Vidyo connection details are available here CERN Vidyo service documentation can be found here First-time users are encouraged to try the service before connecting to the real event

  5. Detection of anomalous events

    Science.gov (United States)

    Ferragut, Erik M.; Laska, Jason A.; Bridges, Robert A.

    2016-06-07

    A system is described for receiving a stream of events and scoring the events based on anomalousness and maliciousness (or other classification). The system can include a plurality of anomaly detectors that together implement an algorithm to identify low-probability events and detect atypical traffic patterns. The anomaly detector provides for comparability of disparate sources of data (e.g., network flow data and firewall logs.) Additionally, the anomaly detector allows for regulatability, meaning that the algorithm can be user configurable to adjust a number of false alerts. The anomaly detector can be used for a variety of probability density functions, including normal Gaussian distributions, irregular distributions, as well as functions associated with continuous or discrete variables.

  6. Coordinated Field Campaigns in Chesapeake Bay and Gulf of Mexico

    Science.gov (United States)

    Mannino, Antonio; Novak, Michael; Tzortziou, Maria A.

    2015-01-01

    NASA's GEOstationary Coastal and Air Pollution Events (GEO-CAPE) mission concept recommended by the U.S. National Research Council (2007) focuses on measurements of atmospheric trace gases and aerosols and aquatic coastal ecology and biogeochemistry from geostationary orbit (35,786 km altitude). Two GEO-CAPE-sponsored multi-investigator ship-based field campaigns were conducted to coincide with the NASA Earth Venture Suborbital project DISCOVER-AQ (Deriving Information on Surface conditions from Column and Vertically Resolved Observations Relevant to Air Quality) field campaigns: (1) Chesapeake Bay in July 2011 and (2) northwestern Gulf of Mexico in September 2013. Goal: to evaluate whether GEO-CAPE coastal mission measurement and instrument requirements are optimized to address science objectives while minimizing ocean color satellite sensor complexity, size and cost - critical mission risk reduction activities. NASA continues to support science studies related to the analysis of data collected as part of these coordinated field campaigns and smaller efforts.

  7. Hybrid Architecture for Coordination of AGVs in FMS

    Directory of Open Access Journals (Sweden)

    Eduardo G. Hernandez-Martinez

    2014-03-01

    Full Text Available This paper presents a hybrid control architecture that coordinates the motion of groups of automated guided vehicles in flexible manufacturing systems. The high-level control is based on a Petri net model, using the industrial standard ISA-95, obtaining a task-based coordination of equipment and storage considering process restrictions, logical precedences, shared resources and the assignment of robots to move workpieces individually or in subgroups. On the other hand, in the low-level control, three basic control laws are designed for unicycle-type robots in order to achieve desired formation patterns and marching behaviours, avoiding inter-robot collisions. The control scheme combines the task assignment for the robots obtained from the discrete-event model and the implementation of formation and marching continuous control laws applied to the motion of the mobile robots. The hybrid architecture is implemented and validated for the case of a flexible manufacturing system and four mobile robots using a virtual reality platform.

  8. A framework of manufacturer-retailer coordination process

    DEFF Research Database (Denmark)

    Wong, Chee Yew; Johansen, John

    2008-01-01

    Purpose - Triggered by perceived inefficiency and inequality, buyers and suppliers coordinate with each other. The purpose of this paper is to develop a framework of coordination process based on theoretical review and verifications from three case studies. Design/methodology/approach - The appro......Purpose - Triggered by perceived inefficiency and inequality, buyers and suppliers coordinate with each other. The purpose of this paper is to develop a framework of coordination process based on theoretical review and verifications from three case studies. Design...... there was disagreement. Third, closer mode of coordination, which involved joint evaluation and derivation of coordination solutions, reduced the numbers of iterative coordination cycles. These empirical findings verified the presupposed framework of coordination process. Research limitations/implications - Three...... qualitative case studies may not be highly generalisable and multiple dyadic coordination processes may occur. However, the findings form a foundation for further understanding of the coordination process. Originality/value - The proposed framework of the coordination process further expands the theories...

  9. DER 83: outstanding events

    International Nuclear Information System (INIS)

    1984-01-01

    The DER's activity is presented through 82 ''outstanding events''. Each one is a stage in the effort of research and development of the DER. These events concern the following fields: new applications of electric power for customers; environment protection and new energy sources; improvements of electric power production units; electrical materials; electric network planning and control; computer codes. In the production field, one deals more particularly with nuclear reactor safety studies: analysis of the behaviour of different components; reactor safety experiments; reliability of different systems (safety, communications...) [fr

  10. Forecasting Turbine Icing Events

    DEFF Research Database (Denmark)

    Davis, Neil; Hahmann, Andrea N.; Clausen, Niels-Erik

    2012-01-01

    In this study, we present a method for forecasting icing events. The method is validated at two European wind farms in with known icing events. The icing model used was developed using current ice accretion methods, and newly developed ablation algorithms. The model is driven by inputs from the WRF...... mesoscale model, allowing for both climatological estimates of icing and short term icing forecasts. The current model was able to detect periods of icing reasonably well at the warmer site. However at the cold climate site, the model was not able to remove ice quickly enough leading to large ice...

  11. Events and Effects

    DEFF Research Database (Denmark)

    Rytter, Mikkel

    2010-01-01

    Analyzing the period of ‘intensive transnationalism’ among Pakistani migrants in Denmark precipitated by the 2005 earthquake in Kashmir, this article explores the relationship between events and effects on a global scale. One significant initiative after the disaster was the founding of an ad hoc......, and national identity politics in Denmark. Despite the medical doctors’ efforts and intentions, the out- come was framed by 9/11, which has become the major critical event of the decade—one that has supported a developing cleavage between the Danish majority and Denmark’s Muslim immigrant minority....

  12. Recurring events - Volume 2

    International Nuclear Information System (INIS)

    2003-04-01

    The feedback of operating experience from nuclear power plants (NPP) is intended to help avoid occurrence or recurrence of safety significant events. Regulatory bodies, and utilities operating nuclear power plants, have established operating experience feedback systems since the beginning of commercial nuclear power production. Well-established operating experience feedback systems exist on national and international level. An example of an international system is the Incident Reporting System (IRS) jointly operated by the International Atomic Energy Agency (IAEA) and the Nuclear Energy Agency (NEA). There also are systems maintained by the operating organizations, including the World Association of Nuclear Operators (WANO), and owner groups of different NPP vendors. Committee on the Safety of Nuclear Installations (CSNI) Working Group on Operating Experience (WGOE; formerly Principal Working Group No. 1, PWG1) carried out a study on recurring events some years ago. This report, published in 1999, highlighted some areas of safety significance involving recurrent events in different NPPs around the world. Based on the important findings of this report, CSNI requested two additional studies: 1. first an international workshop should be organized and second, 2. a task group should be established to develop a second report on the topic and to evaluate the findings of the workshop. The workshop, hosted by the Swiss Regulatory Authority, HSK, was held in Switzerland in March 2002. It was attended by 32 experts representing the regulatory, nuclear power plant, vendor, and international agency communities. Several insights and recommendations were presented and are integrated in this report with respect to causes of recurring events: - Operating experience feedback processes had not always been effective, that is, the existing operating experiences had not been effectively applied, - Actions to be taken were not implemented in a timely manner, - The root cause was not

  13. Polysulfide coordination clusters of the lanthanides

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Ying-Zhao; Bestgen, Sebastian; Gamer, Michael T.; Roesky, Peter W. [Institute of Inorganic Chemistry, Karlsruhe Institute of Technology, Karlsruhe (Germany); Konchenko, Sergey N. [Institute of Inorganic Chemistry, Karlsruhe Institute of Technology, Karlsruhe (Germany); Nikolaev Institute of Inorganic Chemistry, SB RAS, Novosibirsk (Russian Federation); Novosibirsk State University (Russian Federation)

    2017-10-16

    The reaction of [(DippForm){sub 2}Ln(thf){sub 2}] with an excess of elemental sulfur in toluene resulted in the formation of the trinuclear polysulfide coordination clusters [(DippForm){sub 3}Ln{sub 3}S{sub 12}] (Ln=Sm, Yb; DippForm=N,N'-bis(2,6-diisopropylphenyl)formamidinate). These are the first f element coordination clusters (Ln{sub n}S{sub x}) with a larger polysulfide unit (n and x>2). The formation of the coordination clusters can be rationalized by the reductive cleavage of S{sub 8} with divalent lanthanides. (copyright 2017 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

  14. Nonparametric variational optimization of reaction coordinates

    Energy Technology Data Exchange (ETDEWEB)

    Banushkina, Polina V.; Krivov, Sergei V., E-mail: s.krivov@leeds.ac.uk [Astbury Center for Structural Molecular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT (United Kingdom)

    2015-11-14

    State of the art realistic simulations of complex atomic processes commonly produce trajectories of large size, making the development of automated analysis tools very important. A popular approach aimed at extracting dynamical information consists of projecting these trajectories into optimally selected reaction coordinates or collective variables. For equilibrium dynamics between any two boundary states, the committor function also known as the folding probability in protein folding studies is often considered as the optimal coordinate. To determine it, one selects a functional form with many parameters and trains it on the trajectories using various criteria. A major problem with such an approach is that a poor initial choice of the functional form may lead to sub-optimal results. Here, we describe an approach which allows one to optimize the reaction coordinate without selecting its functional form and thus avoiding this source of error.

  15. Non-commutativity in polar coordinates

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, James P. [Universidad Michoacana de San Nicolas de Hidalgo, Ciudad Universitaria, Instituto de Fisica y Matematicas, Morelia, Michoacan (Mexico)

    2017-05-15

    We reconsider the fundamental commutation relations for non-commutative R{sup 2} described in polar coordinates with non-commutativity parameter θ. Previous analysis found that the natural transition from Cartesian coordinates to the traditional polar system led to a representation of [r, φ] as an everywhere diverging series. In this article we compute the Borel resummation of this series, showing that it can subsequently be extended throughout parameter space and hence provide an interpretation of this commutator. Our analysis provides a complete solution for arbitrary r and θ that reproduces the earlier calculations at lowest order and benefits from being generally applicable to problems in a two-dimensional non-commutative space. We compare our results to previous literature in the (pseudo-)commuting limit, finding a surprising spatial dependence for the coordinate commutator when θ >> r{sup 2}. Finally, we raise some questions for future study in light of this progress. (orig.)

  16. Culture-dependent strategies in coordination games.

    Science.gov (United States)

    Jackson, Matthew O; Xing, Yiqing

    2014-07-22

    We examine different populations' play in coordination games in online experiments with over 1,000 study participants. Study participants played a two-player coordination game that had multiple equilibria: two equilibria with highly asymmetric payoffs and another equilibrium with symmetric payoffs but a slightly lower total payoff. Study participants were predominantly from India and the United States. Study participants residing in India played the strategies leading to asymmetric payoffs significantly more frequently than study participants residing in the United States who showed a greater play of the strategy leading to the symmetric payoffs. In addition, when prompted to play asymmetrically, the population from India responded even more significantly than those from the United States. Overall, study participants' predictions of how others would play were more accurate when the other player was from their own populations, and they coordinated significantly more frequently and earned significantly higher payoffs when matched with other study participants from their own population than when matched across populations.

  17. Coordination: Neural, Behavioral and Social Dynamics

    CERN Document Server

    Fuchs, Armin

    2008-01-01

    One of the most striking features of Coordination Dynamics is its interdisciplinary character. The problems we are trying to solve in this field range from behavioral phenomena of interlimb coordination and coordination between stimuli and movements (perception-action tasks) through neural activation patterns that can be observed during these tasks to clinical applications and social behavior. It is not surprising that close collaboration among scientists from different fields as psychology, kinesiology, neurology and even physics are imperative to deal with the enormous difficulties we are facing when we try to understand a system as complex as the human brain. The chapters in this volume are not simply write-ups of the lectures given by the experts at the meeting but are written in a way that they give sufficient introductory information to be comprehensible and useful for all interested scientists and students.

  18. TIARA: Toward accelerator R&D coordination

    CERN Multimedia

    Anaïs Schaeffer

    2011-01-01

    The preparatory phase of the TIARA (Test Infrastructure and Accelerator Research Area) project has begun. In January, members from 11 research institutes in 8 European countries began a three-year collaboration intended to enhance, improve and structure R&D efforts in the area of accelerator science and technology in Europe.   Partly funded by the European Commission under its Seventh Framework Programme (FP7), the TIARA project is being coordinated by the CEA (Commissariat à l’Énergie Atomique et aux Energies Alternatives). “The aim of the project is to arrive at an organisational structure that will provide coordination for R&D efforts and associated infrastructures in the field of particle accelerators in Europe,” explains the CEA’s Céline Tanguy, project coordinator assistant. “The new structure, which we hope will be a durable one, will be set up at the end of the project’s preparatory phase....

  19. Conflict as driver of pluricentric coordination

    DEFF Research Database (Denmark)

    Sørensen, Eva

    2014-01-01

    and reconstructing the institutional conditions that make coordination possible. The productive role of conflicts is particularly visible in times of radical change that calls for a recasting of the sedimented world views and practices of the involved actors, as well as the relationship between them. A case study......Governance theory and planning theory share a tendency to either overlook the role of conflicts in coordination processes or view them as a disruptive force that must be modified or neutralized. In effect, there is little research into the productive role of conflicts in constructing...... of the formation of new pluricentric regional governance arenas in Denmark provides important insights into how conflicts contribute to a gradual recasting of the institutional conditions that make coordination possible....

  20. Anatomic breast coordinate system for mammogram analysis

    DEFF Research Database (Denmark)

    Karemore, Gopal; Brandt, S.; Karssemeijer, N.

    2011-01-01

    was represented by geodesic distance (s) from nipple and parametric angle (¿) as shown in figure 1. The scoring technique called MTR (mammographic texture resemblance marker) used this breast coordinate system to extract Gaussian derivative features. The features extracted using the (x,y) and the curve......Purpose Many researchers have investigated measures also other than density in the mammogram such as measures based on texture to improve breast cancer risk assessment. However, parenchymal texture characteristics are highly dependent on the orientation of vasculature structure and fibrous tissue...... methodologies as seen from table 2 in given temporal study. Conclusion The curve-linear anatomical breast coordinate system facilitated computerized analysis of mammograms. The proposed coordinate system slightly improved the risk segregation by Mammographic Texture Resemblance and minimized the geometrical...

  1. Impaired Visual Motor Coordination in Obese Adults.

    LENUS (Irish Health Repository)

    Gaul, David

    2016-09-01

    Objective. To investigate whether obesity alters the sensory motor integration process and movement outcome during a visual rhythmic coordination task. Methods. 88 participants (44 obese and 44 matched control) sat on a chair equipped with a wrist pendulum oscillating in the sagittal plane. The task was to swing the pendulum in synchrony with a moving visual stimulus displayed on a screen. Results. Obese participants demonstrated significantly (p < 0.01) higher values for continuous relative phase (CRP) indicating poorer level of coordination, increased movement variability (p < 0.05), and a larger amplitude (p < 0.05) than their healthy weight counterparts. Conclusion. These results highlight the existence of visual sensory integration deficiencies for obese participants. The obese group have greater difficulty in synchronizing their movement with a visual stimulus. Considering that visual motor coordination is an essential component of many activities of daily living, any impairment could significantly affect quality of life.

  2. Strained coordinate methods in rotating stars. II

    International Nuclear Information System (INIS)

    Smith, B.L.

    1977-01-01

    It was shown in a previous paper (Smith, 1976) that the method of strained coordinates may be usefully employed in the determination of the structure of rotating polytropes. In the present work this idea is extended to Main-Sequence stars with conservative centrifugal fields. The structure variables, pressure, density and temperature are considered pure functions of an auxiliary coordinate s (the strained coordinate) and the governing equations written in a form that closely resembles the structure equations for spherical stars but with the correction factors that are functions of s. A systematic, order-by-order derivation of these factors is outlined and applied in detail to a Cowling-model star in uniform rotation. The techniques can be extended beyond first order and external boundary conditions are applied, as they should be, at the true surface of the star. Roche approximations are not needed. (Auth.)

  3. Improving care coordination using organisational routines

    DEFF Research Database (Denmark)

    Prætorius, Thim

    2016-01-01

    Purpose – The purpose of this paper is to systematically apply theory of organisational routines to standardised care pathways. The explanatory power of routines is used to address open questions in the care pathway literature about their coordinating and organising role, the way they change......: care pathways and coordination, change, replication, the organisation and health care professionals. Research limitations/implications – The paper is conceptual and uses care pathways as illustrative instances of hospital routines. The propositions provide a starting point for empirical research....... Practical implications – The analysis highlights implications that health care professionals and managers have to consider in relation to coordination, change, replication, the way the organisation influences care pathways and the way care pathways influence health care professionals. Originality...

  4. Coordinate sensitive detectors based on microchannel plates

    International Nuclear Information System (INIS)

    Gruntman, M.A.

    1984-01-01

    Coordinate-sensitive detectors (CSD) on the basis of microchannel plates permit to determine in a digital form the coordinates of every recorded particle and they are used in different fields of physical experiment. The sensitive surface diameter of such detectors can reach 10 cm, and spatial resolution - 10 μm. In the review provided CSD with microchannel plates are classified according to the ways of coordinate determination, different types of the detectors, pecUliarities of their design and electron flowsheet are described. It is pointed out that there are reasons for introduction of CSD into practice of laboratory physical investigations in various fields, where the particle recorded is electron or is able to form a secondary electron. It is attributed to nuclear physics, physics of electron and atom collisions, optics, mass-spectrometry, electron microscopy, X-ray analysis, investigation of surfaces

  5. Coordinated Voltage Control of Active Distribution Network

    Directory of Open Access Journals (Sweden)

    Xie Jiang

    2016-01-01

    Full Text Available This paper presents a centralized coordinated voltage control method for active distribution network to solve off-limit problem of voltage after incorporation of distributed generation (DG. The proposed method consists of two parts, it coordinated primal-dual interior point method-based voltage regulation schemes of DG reactive powers and capacitors with centralized on-load tap changer (OLTC controlling method which utilizes system’s maximum and minimum voltages, to improve the qualified rate of voltage and reduce the operation numbers of OLTC. The proposed coordination has considered the cost of capacitors. The method is tested using a radial edited IEEE-33 nodes distribution network which is modelled using MATLAB.

  6. Obesity and Motor Coordination Ability in Taiwanese Children with and without Developmental Coordination Disorder

    Science.gov (United States)

    Zhu, Yi-Ching; Wu, Sheng K.; Cairney, John

    2011-01-01

    The purpose of this study was to investigate the associations between obesity and motor coordination ability in Taiwanese children with and without developmental coordination disorder (DCD). 2029 children (1078 boys, 951 girls) aged nine to ten years were chosen randomly from 14 elementary schools across Taiwan. We used bioelectrical impedance…

  7. Variationally optimal selection of slow coordinates and reaction coordinates in macromolecular systems

    Science.gov (United States)

    Noe, Frank

    To efficiently simulate and generate understanding from simulations of complex macromolecular systems, the concept of slow collective coordinates or reaction coordinates is of fundamental importance. Here we will introduce variational approaches to approximate the slow coordinates and the reaction coordinates between selected end-states given MD simulations of the macromolecular system and a (possibly large) basis set of candidate coordinates. We will then discuss how to select physically intuitive order paremeters that are good surrogates of this variationally optimal result. These result can be used in order to construct Markov state models or other models of the stationary and kinetics properties, in order to parametrize low-dimensional / coarse-grained model of the dynamics. Deutsche Forschungsgemeinschaft, European Research Council.

  8. Business Event Notification Service (BENS)

    Data.gov (United States)

    Department of Veterans Affairs — BENS provides a notification of pre-defined business events to applications, portals, and automated business processes. Such events are defined in the Event Catalog,...

  9. Wroclaw neutrino event generator

    International Nuclear Information System (INIS)

    Nowak, J A

    2006-01-01

    A neutrino event generator developed by the Wroclaw Neutrino Group is described. The physical models included in the generator are discussed and illustrated with the results of simulations. The considered processes are quasi-elastic scattering and pion production modelled by combining the Δ resonance excitation and deep inelastic scattering

  10. The CMS Event Builder

    CERN Document Server

    Brigljevic, V; Cano, E; Cittolin, Sergio; Csilling, Akos; Gigi, D; Glege, F; Gómez-Reino, Robert; Gulmini, M; Gutleber, J; Jacobs, C; Kozlovszky, Miklos; Larsen, H; Magrans de Abril, Ildefons; Meijers, F; Meschi, E; Murray, S; Oh, A; Orsini, L; Pollet, L; Rácz, A; Samyn, D; Scharff-Hansen, P; Schwick, C; Sphicas, Paris; ODell, V; Suzuki, I; Berti, L; Maron, G; Toniolo, N; Zangrando, L; Ninane, A; Erhan, S; Bhattacharya, S; Branson, J G

    2003-01-01

    The data acquisition system of the CMS experiment at the Large Hadron Collider will employ an event builder which will combine data from about 500 data sources into full events at an aggregate throughput of 100 GByte/s. Several architectures and switch technologies have been evaluated for the DAQ Technical Design Report by measurements with test benches and by simulation. This paper describes studies of an EVB test-bench based on 64 PCs acting as data sources and data consumers and employing both Gigabit Ethernet and Myrinet technologies as the interconnect. In the case of Ethernet, protocols based on Layer-2 frames and on TCP/IP are evaluated. Results from ongoing studies, including measurements on throughput and scaling are presented. The architecture of the baseline CMS event builder will be outlined. The event builder is organised into two stages with intelligent buffers in between. The first stage contains 64 switches performing a first level of data concentration by building super-fragments from fragmen...

  11. The ATLAS event filter

    CERN Document Server

    Beck, H P; Boissat, C; Davis, R; Duval, P Y; Etienne, F; Fede, E; Francis, D; Green, P; Hemmer, F; Jones, R; MacKinnon, J; Mapelli, Livio P; Meessen, C; Mommsen, R K; Mornacchi, Giuseppe; Nacasch, R; Negri, A; Pinfold, James L; Polesello, G; Qian, Z; Rafflin, C; Scannicchio, D A; Stanescu, C; Touchard, F; Vercesi, V

    1999-01-01

    An overview of the studies for the ATLAS Event Filter is given. The architecture and the high level design of the DAQ-1 prototype is presented. The current status if the prototypes is briefly given. Finally, future plans and milestones are given. (11 refs).

  12. Negligence and Athletic Events.

    Science.gov (United States)

    Mawdsley, Ralph D.

    2001-01-01

    Although athletic events generate their share of negligence lawsuits, the relatively small number, compared with other education areas, suggests that defenses (like assumption or risk and contributory negligence) have a better fit in athletics. Implications of newer litigation trends involving coaches' misconduct and interpretation of state…

  13. On Objects and Events

    DEFF Research Database (Denmark)

    Eugster, Patrick Thomas; Guerraoui, Rachid; Damm, Christian Heide

    2001-01-01

    This paper presents linguistic primitives for publish/subscribe programming using events and objects. We integrate our primitives into a strongly typed object-oriented language through four mechanisms: (1) serialization, (2) multiple sub typing, (3) closures, and (4) deferred code evaluation. We...

  14. Load event: Aircraft crash

    International Nuclear Information System (INIS)

    Fritsch, H.

    1985-01-01

    The bibliography includes 48 quotations, up to the year 1983, on the following issues: Experiments and computational methods. Design load for the dimensioning of reinforced concrete buildings and components with respect to the dynamic load in the event of an aircraft crash. (orig./HP) [de

  15. Preparedness events in 2008

    International Nuclear Information System (INIS)

    2009-01-01

    NRPA have as Secretariat for the Crisis Committee and the nuclear preparedness organization in 2008 published several reports of incidents of radioactivity and radioactive pollution to the nuclear preparedness organization, media and the public. In addition to these events, there have been some incidents with radiation and small radioactive sources in Norway during this year. (AG)

  16. Event Classification using Concepts

    NARCIS (Netherlands)

    Boer, M.H.T. de; Schutte, K.; Kraaij, W.

    2013-01-01

    The semantic gap is one of the challenges in the GOOSE project. In this paper a Semantic Event Classification (SEC) system is proposed as an initial step in tackling the semantic gap challenge in the GOOSE project. This system uses semantic text analysis, multiple feature detectors using the BoW

  17. Traumatic events and children

    Science.gov (United States)

    ... over and over again Know the Signs of Post-traumatic Stress Disorder (PTSD) Half of the children who survive traumatic events ... team. Related MedlinePlus Health Topics Child Mental Health Post-Traumatic Stress Disorder Browse the Encyclopedia A.D.A.M., Inc. ...

  18. Torque Coordination Control during Braking Mode Switch for a Plug-in Hybrid Electric Vehicle

    Directory of Open Access Journals (Sweden)

    Yang Yang

    2017-10-01

    Full Text Available Hybrid vehicles usually have several braking systems, and braking mode switches are significant events during braking. It is difficult to coordinate torque fluctuations caused by mode switches because the dynamic characteristics of braking systems are different. In this study, a new type of plug-in hybrid vehicle is taken as the research object, and braking mode switches are divided into two types. The control strategy of type one is achieved by controlling the change rates of clutch hold-down and motor braking forces. The control strategy of type two is achieved by simultaneously changing the target braking torque during different mode switch stages and controlling the motor to participate in active coordination control. Finally, the torque coordination control strategy is modeled in MATLAB/Simulink, and the results show that the proposed control strategy has a good effect in reducing the braking torque fluctuation and vehicle shocks during braking mode switches.

  19. Coordination under the Shadow of Career Concerns

    DEFF Research Database (Denmark)

    Koch, Alexander; Morgenstern, Albrecht

    2010-01-01

    concerns arise. The effects of career concerns can both be 'good' (enhancing incentives for effort in developing ideas) and 'bad' (preventing voluntary coordination). Our model shows how a firm can take these conflicting forces into account through the design of its explicit incentive system and the way......A firm's innovation process requires employees to develop novel ideas and to coordinate with each other to turn the tacit knowledge embodying these ideas into better products and services. Such work outcomes provide signals about employees' abilities to the labor market, and therefore career...

  20. Collective motion and the generator coordinate method

    International Nuclear Information System (INIS)

    Passos, E.J.V. de

    1981-01-01

    The generator coordinate method is used to construct a collective subspace of the many-body Hylbert space. The construction is based on the analysis of the properties of the overlaps of the generator states. Some well-known misbehaviours of the generator coordinate weight functions are clearly identified as of kinematical origin. A standard orthonormal representation in the collective subspace is introduced which eliminates them. It is also indicated how appropriate collective dynamical variables can be defined a posteriori. To illustrate the properties of the collective subspaces applications are made to a) translational invariant overlap kernels b) to one and two-conjugate parameter families of generator states. (Author) [pt