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Sample records for partial response conclusion

  1. Conclusion

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Conclusion. Problems of an Under-developed Economy. Geographical Location. Terrain. Change in attitude of mainstream India required. Using Technology to overcome problems.

  2. Conclusions

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Conclusions. Be it 2G or 4G, networks are vulnerable to unwanted access and thus should be protected. 4G networks would be more sensitive as its core network will be TCP/IP based. Accordingly, resource and security management schemes with seamless ...

  3. Conclusions:

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Conclusions: Extended objects – “D-branes” – appear naturally in theories of strings. They manifest themselves as new types of physical particles in string models. They provide a powerful handle on the symmetries and dynamics of strings. Branes will play a key role ...

  4. Conclusions :

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Conclusions : No dramatic difference in the dynamics of anion-water and water-water hydrogen bonds are found for Cl- and Br- ions. Solvation shells of these ions are not rigid. For OH- in water, HB dynamics in the hydration shell determines the rate of proton transfer.

  5. Conclusion

    DEFF Research Database (Denmark)

    Sandøy, Helge; Kristiansen, Tore

    2010-01-01

    1. Comparing empirical findings with the “mountain peak model” In the introduction to this volume, we presented a “mountain peak model” of Nordic purism based on evidence showing that language scholars and lay people are very much in agreement as to where we find the more purist languages......-speaking Finland to Finnish-speaking Finland. In this conclusion to the volume, we will summarize the empirical findings presented in the volume, findings for use and attitudes alike, and compare them with the mountain peak model. That way, we may be able to estimate the nature of the cross-national ideological...

  6. Conclusion

    International Nuclear Information System (INIS)

    Ainul Hayati Daud; Hazmimi Kasim

    2010-01-01

    In Asia, Japan and the Republic of Korea have conducted similar studies but relying on statistical data and used inputs and outputs (I-O) methodology, utilizing on general macro-level data. In contrast, this study captures data directly through surveys using questionnaires, face-to-face interviews, case studies and focus group discussions. The impact of nuclear technology applications in Malaysia were evaluated both quantitatively and qualitatively. These impacts are then linked to a broader objective associated with technological development, namely wealth generation, knowledge generation and societal well-being. In the process of the study, users and practitioners of the technology highlighted issues and challenges faced by them. To cap the study, the level of activities of nuclear technology in Malaysia was benchmarked against those in Japan and the Republic of Korea. This chapter highlights the results of the study, the outcome of the study, followed by recommendations as response to issues and challenges raised by respondents, and finally the way forward for monitoring and charting further progress of nuclear technology in the country. (author)

  7. Different partial volume correction methods lead to different conclusions

    DEFF Research Database (Denmark)

    Greve, Douglas N; Salat, David H; Bowen, Spencer L

    2016-01-01

    A cross-sectional group study of the effects of aging on brain metabolism as measured with (18)F-FDG-PET was performed using several different partial volume correction (PVC) methods: no correction (NoPVC), Meltzer (MZ), Müller-Gärtner (MG), and the symmetric geometric transfer matrix (SGTM) usin...

  8. Regret and Responsibility Resolved? Evaluation Ordonez and Connolly's Conclusions.

    NARCIS (Netherlands)

    Zeelenberg, M.; van Dijk, W.W.; Manstead, A.S.R.

    2000-01-01

    T. Connolly, L. D. Ordo;aan;atez, and R. Coughlan (1997, Organizational Behavior and Human Decision Processes, 70, 73-85) argued, on the basis of 5 experiments, that regret need not be related to a sense of responsibility for the regretted outcome. We (M. Zeelenberg, W. W. van Dijk, & A. S. R.

  9. Different partial volume correction methods lead to different conclusions: An (18)F-FDG-PET study of aging.

    Science.gov (United States)

    Greve, Douglas N; Salat, David H; Bowen, Spencer L; Izquierdo-Garcia, David; Schultz, Aaron P; Catana, Ciprian; Becker, J Alex; Svarer, Claus; Knudsen, Gitte M; Sperling, Reisa A; Johnson, Keith A

    2016-05-15

    A cross-sectional group study of the effects of aging on brain metabolism as measured with (18)F-FDG-PET was performed using several different partial volume correction (PVC) methods: no correction (NoPVC), Meltzer (MZ), Müller-Gärtner (MG), and the symmetric geometric transfer matrix (SGTM) using 99 subjects aged 65-87years from the Harvard Aging Brain study. Sensitivity to parameter selection was tested for MZ and MG. The various methods and parameter settings resulted in an extremely wide range of conclusions as to the effects of age on metabolism, from almost no changes to virtually all of cortical regions showing a decrease with age. Simulations showed that NoPVC had significant bias that made the age effect on metabolism appear to be much larger and more significant than it is. MZ was found to be the same as NoPVC for liberal brain masks; for conservative brain masks, MZ showed few areas correlated with age. MG and SGTM were found to be similar; however, MG was sensitive to a thresholding parameter that can result in data loss. CSF uptake was surprisingly high at about 15% of that in gray matter. The exclusion of CSF from SGTM and MG models, which is almost universally done, caused a substantial loss in the power to detect age-related changes. This diversity of results reflects the literature on the metabolism of aging and suggests that extreme care should be taken when applying PVC or interpreting results that have been corrected for partial volume effects. Using the SGTM, significant age-related changes of about 7% per decade were found in frontal and cingulate cortices as well as primary visual and insular cortices. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Different Partial Volume Correction Methods Lead to Different Conclusions: an 18F-FDG PET Study of Aging

    Science.gov (United States)

    Greve, Douglas N.; Salat, David H.; Bowen, Spencer L.; Izquierdo-Garcia, David; Schultz, Aaron P.; Catana, Ciprian; Becker, J. Alex; Svarer, Claus; Knudsen, Gitte; Sperling, Reisa A.; Johnson, Keith A.

    2016-01-01

    A cross-sectional group study of the effects of aging on brain metabolism as measured with 18F-FDG PET was performed using several different partial volume correction (PVC) methods: no correction (NoPVC), Meltzer (MZ), Müller-Gärtner (MG), and the symmetric geometric transfer matrix (SGTM) using 99 subjects aged 65-87 from the Harvard Aging Brain study. Sensitivity to parameter selection was tested for MZ and MG. The various methods and parameter settings resulted in an extremely wide range of conclusions as to the effects of age on metabolism, from almost no changes to virtually all of cortical regions showing a decrease with age. Simulations showed that NoPVC had significant bias that made the age effect on metabolism appear to be much larger and more significant than it is. MZ was found to be the same as NoPVC for liberal brain masks; for conservative brain masks, MZ showed few areas correlated with age. MG and SGTM were found to be similar; however, MG was sensitive to a thresholding parameter that can result in data loss. CSF uptake was surprisingly high at about 15% of that in gray matter. Exclusion of CSF from SGTM and MG models, which is almost universally done, caused a substantial loss in the power to detect age-related changes. This diversity of results reflects the literature on the metabolism of aging and suggests that extreme care should be taken when applying PVC or interpreting results that have been corrected for partial volume effects. Using the SGTM, significant age-related changes of about 7% per decade were found in frontal and cingulate cortices as well as primary visual and insular cortices. PMID:26915497

  11. Response Styles in the Partial Credit Model

    OpenAIRE

    Tutz, Gerhard; Schauberger, Gunther; Berger, Moritz

    2016-01-01

    In the modelling of ordinal responses in psychological measurement and survey- based research, response styles that represent specific answering patterns of respondents are typically ignored. One consequence is that estimates of item parameters can be poor and considerably biased. The focus here is on the modelling of a tendency to extreme or middle categories. An extension of the Partial Credit Model is proposed that explicitly accounts for this specific response style. In contrast to exi...

  12. Regret and Responsibility Resolved? Evaluating Ordóñez and Connolly's (2000) Conclusions.

    Science.gov (United States)

    Zeelenberg; van Dijk WW; Manstead

    2000-01-01

    T. Connolly, L. D. Ordo;aan;atez, and R. Coughlan (1997, Organizational Behavior and Human Decision Processes, 70, 73-85) argued, on the basis of 5 experiments, that regret need not be related to a sense of responsibility for the regretted outcome. We (M. Zeelenberg, W. W. van Dijk, & A. S. R. Manstead, 1998, Organizational Behavior and Human Decision Processes, 74, 254-272) showed in 2 experiments that this conclusion was premature, because it was based on an indirect measure of regret (i.e., overall happiness with the decision outcome). When regret was directly measured, the predicted effects of responsibility were found. L. D. Ordo;aan;atez and T. Connolly (2000, Organizational Behavior and Human Decision Processes, 81, 132-142) replicated our findings in 2 experiments. Based on their findings they arrived at 4 conclusions. In this rejoinder we first discuss Ordóñez and Connolly's new studies and we then discuss the validity of their 4 conclusions. Copyright 2000 Academic Press.

  13. A conclusive scalable model for the complete actuation response for IPMC transducers

    International Nuclear Information System (INIS)

    McDaid, A J; Aw, K C; Haemmerle, E; Xie, S Q

    2010-01-01

    This paper proposes a conclusive scalable model for the complete actuation response for ionic polymer metal composites (IPMC). This single model is proven to be able to accurately predict the free displacement/velocity and force actuation at varying displacements, with up to 3 V inputs. An accurate dynamic relationship between the force and displacement has been established which can be used to predict the complete actuation response of the IPMC transducer. The model is accurate at large displacements and can also predict the response when interacting with external mechanical systems and loads. This model equips engineers with a useful design tool which enables simple mechanical design, simulation and optimization when integrating IPMC actuators into an application. The response of the IPMC is modelled in three stages: (i) a nonlinear equivalent electrical circuit to predict the current drawn, (ii) an electromechanical coupling term and (iii) a segmented mechanical beam model which includes an electrically induced torque for the polymer. Model parameters are obtained using the dynamic time response and results are presented demonstrating the correspondence between the model and experimental results over a large operating range. This newly developed model is a large step forward, aiding in the progression of IPMCs towards wide acceptance as replacements to traditional actuators

  14. Unraveling uranium induced oxidative stress related responses in Arabidopsis thaliana seedlings. Part II: responses in the leaves and general conclusions.

    Science.gov (United States)

    Vanhoudt, Nathalie; Cuypers, Ann; Horemans, Nele; Remans, Tony; Opdenakker, Kelly; Smeets, Karen; Bello, Daniel Martinez; Havaux, Michel; Wannijn, Jean; Van Hees, May; Vangronsveld, Jaco; Vandenhove, Hildegarde

    2011-06-01

    The cellular redox balance seems an important modulator under heavy metal stress. While for other heavy metals these processes are well studied, oxidative stress related responses are also known to be triggered under uranium stress but information remains limited. This study aimed to further unravel the mechanisms by which plants respond to uranium stress. Seventeen-day-old Arabidopsis thaliana seedlings, grown on a modified Hoagland solution under controlled conditions, were exposed to 0, 0.1, 1, 10 and 100 μM uranium for 1, 3 and 7 days. While in Part I of this study oxidative stress related responses in the roots were discussed, this second Part II discusses oxidative stress related responses in the leaves and general conclusions drawn from the results of the roots and the leaves will be presented. As several responses were already visible following 1 day exposure, when uranium concentrations in the leaves were negligible, a root-to-shoot signaling system was suggested in which plastids could be important sensing sites. While lipid peroxidation, based on the amount of thiobarbituric acid reactive compounds, was observed after exposure to 100 μM uranium, affecting membrane structure and function, a transient concentration dependent response pattern was visible for lipoxygenase initiated lipid peroxidation. This transient character of uranium stress responses in leaves was emphasized by results of lipoxygenase (LOX2) and antioxidative enzyme transcript levels, enzyme capacities and glutathione concentrations both in time as with concentration. The ascorbate redox balance seemed an important modulator of uranium stress responses in the leaves as in addition to the previous transient responses, the total ascorbate concentration and ascorbate/dehydroascorbate redox balance increased in a concentration and time dependent manner. This could represent either a slow transient response or a stable increase with regard to plant acclimation to uranium stress. Copyright

  15. Unraveling uranium induced oxidative stress related responses in Arabidopsis thaliana seedlings. Part II: responses in the leaves and general conclusions

    Energy Technology Data Exchange (ETDEWEB)

    Vanhoudt, Nathalie, E-mail: nvanhoud@sckcen.be [Belgian Nuclear Research Center (SCK-CEN), Biosphere Impact Studies, Boeretang 200, 2400 Mol (Belgium); Hasselt University, Environmental Biology, Centre for Environmental Sciences, Agoralaan Building D, 3590 Diepenbeek (Belgium); Cuypers, Ann [Hasselt University, Environmental Biology, Centre for Environmental Sciences, Agoralaan Building D, 3590 Diepenbeek (Belgium); Horemans, Nele [Belgian Nuclear Research Center (SCK-CEN), Biosphere Impact Studies, Boeretang 200, 2400 Mol (Belgium); Remans, Tony; Opdenakker, Kelly; Smeets, Karen [Hasselt University, Environmental Biology, Centre for Environmental Sciences, Agoralaan Building D, 3590 Diepenbeek (Belgium); Bello, Daniel Martinez [Hasselt University, Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Agoralaan Building D, 3590 Diepenbeek (Belgium); Havaux, Michel [Commissariat a l' Energie Atomique (CEA)/Cadarache, Direction des Sciences du Vivant, Departement d' Ecophysiologie Vegetale et de Microbiologie, Laboratoire d' Ecophysiologie de la Photosynthese, 13108 Saint-Paul-lez-Durance (France); Wannijn, Jean; Van Hees, May [Belgian Nuclear Research Center (SCK-CEN), Biosphere Impact Studies, Boeretang 200, 2400 Mol (Belgium); Vangronsveld, Jaco [Hasselt University, Environmental Biology, Centre for Environmental Sciences, Agoralaan Building D, 3590 Diepenbeek (Belgium); Vandenhove, Hildegarde [Belgian Nuclear Research Center (SCK-CEN), Biosphere Impact Studies, Boeretang 200, 2400 Mol (Belgium)

    2011-06-15

    The cellular redox balance seems an important modulator under heavy metal stress. While for other heavy metals these processes are well studied, oxidative stress related responses are also known to be triggered under uranium stress but information remains limited. This study aimed to further unravel the mechanisms by which plants respond to uranium stress. Seventeen-day-old Arabidopsis thaliana seedlings, grown on a modified Hoagland solution under controlled conditions, were exposed to 0, 0.1, 1, 10 and 100 {mu}M uranium for 1, 3 and 7 days. While in Part I of this study oxidative stress related responses in the roots were discussed, this second Part II discusses oxidative stress related responses in the leaves and general conclusions drawn from the results of the roots and the leaves will be presented. As several responses were already visible following 1 day exposure, when uranium concentrations in the leaves were negligible, a root-to-shoot signaling system was suggested in which plastids could be important sensing sites. While lipid peroxidation, based on the amount of thiobarbituric acid reactive compounds, was observed after exposure to 100 {mu}M uranium, affecting membrane structure and function, a transient concentration dependent response pattern was visible for lipoxygenase initiated lipid peroxidation. This transient character of uranium stress responses in leaves was emphasized by results of lipoxygenase (LOX2) and antioxidative enzyme transcript levels, enzyme capacities and glutathione concentrations both in time as with concentration. The ascorbate redox balance seemed an important modulator of uranium stress responses in the leaves as in addition to the previous transient responses, the total ascorbate concentration and ascorbate/dehydroascorbate redox balance increased in a concentration and time dependent manner. This could represent either a slow transient response or a stable increase with regard to plant acclimation to uranium stress

  16. Partiality of Responsibility: Ethics in Sustainability Consulting

    NARCIS (Netherlands)

    Earhart, R.S.

    2011-01-01

    Sustainability, Socially Responsible Investment (SRI) and Corporate Social Responsibility (CSR) are both highly normative fields of professional practice, framed by various narratives: capitalist versus environmentalist, waste versus respect for the planet, consumerism versus responsibility;

  17. Sweet Conclusion

    Science.gov (United States)

    Shirley, Britt M.; Wooldridge, Barbara Ross; Camp, Kerri M.

    2012-01-01

    Jen Harrington is the owner and pastry chef of Sweet Conclusion, a bakery in Tampa, Florida. Most of Harrington's business comes from baking wedding cakes, but she has been attempting to attract customers to her retail bakery, where she sells cupcakes, pies, ice cream, and coffee. Nearly four years she opened Sweet Conclusion, the retail part of…

  18. Conclusion; Zaklyuchenie

    Energy Technology Data Exchange (ETDEWEB)

    Nikitin, V I

    1961-07-01

    In this chapter of book are present conclusions about work done by author, in particular that he found comparatively simple and available ways of synthesis of glycerin of acetylene line and glycerin of ethylen line which before was unknown or almost unknown in the chemical literature.

  19. General conclusions

    International Nuclear Information System (INIS)

    Tubiana, M.

    1993-01-01

    In conclusion, a general consensus of a number of points which the author endeavours to summarize in this article: -doctors are an excellent channel for passing on information to the public -doctors feel that they do not know enough about the subject and a training on radiobiology and radiation protection is a necessity for them -communication between doctors and the general public is poor in this field -research should be encouraged in numerous areas such as: carcinogenic effect of low doses of radiation, pedagogy and risk perception

  20. 5. Conclusion

    OpenAIRE

    Beerli, Monique Jo

    2013-01-01

    Attracted by conflict and war, starvation and disease, natural disasters and underdevelopment, discrimination and injustice, solidarity organizations and their supporters engage themselves in struggles for the acquisition of benefits that they themselves will not receive. In the absence of political solutions addressing the demands of a given people, non-state actors are capable of appropriating functions and responsibilities upon themselves which the state is unwilling or unable to perform. ...

  1. Sampling season affects conclusions on soil arthropod community structure responses to metal pollution in Mediterranean urban soils

    NARCIS (Netherlands)

    Santorufo, L.; van Gestel, C.A.M.; Maisto, G.

    2014-01-01

    This study aimed to assess if the period of sampling affected conclusions on the responses of arthropod community structure to metal pollution in urban soils in the Mediterranean area. Higher temperature and lower precipitation were detected in autumn than in spring. In both samplings, the most

  2. Ecosystem Responses to Partial Harvesting in Eastern Boreal Mixedwood Stands

    Directory of Open Access Journals (Sweden)

    Brian D. Harvey

    2013-05-01

    Full Text Available Partial harvesting has been proposed as a key aspect to implementing ecosystem management in the Canadian boreal forest. We report on a replicated experiment located in boreal mixedwoods of Northwestern Quebec. In the winter of 2000–2001, two partial harvesting treatments, one using a dispersed pattern, and a second, which created a (400 m2 gap pattern, were applied to a 90-year-old aspen-dominated mixed stand. The design also included a clear cut and a control. Over the course of the following eight years, live tree, coarse woody debris, regeneration and ground beetles were inventoried at variable intervals. Our results indicate that all harvesting treatments created conditions favorable to balsam fir (Abies balsamea sapling growth and trembling aspen (Populus tremuloides sapling recruitment. However, balsam fir and trembling aspen regeneration and ground beetles response to gap cuts were closer to patterns observed in clear cuts than in dispersed harvesting. The underlying reasons for these differing patterns can be linked to factors associated with the contrasting light regimes created by the two partial harvesting treatments. The study confirms that partially harvesting is an ecologically sound approach in boreal mixedwoods and could contribute to maintaining the distribution of stand ages at the landscape level.

  3. Partial clinical response to anakinra in severe palmoplantar pustular psoriasis.

    Science.gov (United States)

    Tauber, M; Viguier, M; Alimova, E; Petit, A; Lioté, F; Smahi, A; Bachelez, H

    2014-09-01

    Palmoplantar pustular psoriasis is a clinical psoriasis variant characterised by a high impact on quality of life and poor response to biologics approved for plaque type psoriasis.The recombinant interleukin-1 (IL-1) receptor antagonist anakinra has been recently used for the treatment of isolated refractory cases of generalised pustular psoriasis with contrasted results. To report the clinical response in two patients treated with anakinra as salvage therapy in two patients with severe palmoplantar pustular psoriasis refractory to currently available antipsoriatic systemic therapies. Anakinra was given subcutaneously at the daily dose of 100 mg, and clinical response was evaluated using the palmoplantar psoriasis area and severity index (PPPASI). Only partial and transient responses were observed in both patients, who had to stop anakinra due to lack of efficacy and to side effects. Anakinra appears to provide only partial clinical improvement in refractory palmoplantar pustular psoriasis. Prospective clinical studies on larger populations are warranted to investigate more accurately both efficacy and safety of IL-1-inhibiting strategies in pustular psoriasis. © 2014 British Association of Dermatologists.

  4. Seismic Response Analysis of Continuous Multispan Bridges with Partial Isolation

    Directory of Open Access Journals (Sweden)

    E. Tubaldi

    2015-01-01

    Full Text Available Partially isolated bridges are a particular class of bridges in which isolation bearings are placed only between the piers top and the deck whereas seismic stoppers restrain the transverse motion of the deck at the abutments. This paper proposes an analytical formulation for the seismic analysis of these bridges, modelled as beams with intermediate viscoelastic restraints whose properties describe the pier-isolator behaviour. Different techniques are developed for solving the seismic problem. The first technique employs the complex mode superposition method and provides an exact benchmark solution to the problem at hand. The two other simplified techniques are based on an approximation of the displacement field and are useful for preliminary assessment and design purposes. A realistic bridge is considered as case study and its seismic response under a set of ground motion records is analyzed. First, the complex mode superposition method is applied to study the characteristic features of the dynamic and seismic response of the system. A parametric analysis is carried out to evaluate the influence of support stiffness and damping on the seismic performance. Then, a comparison is made between the exact solution and the approximate solutions in order to evaluate the accuracy and suitability of the simplified analysis techniques for evaluating the seismic response of partially isolated bridges.

  5. [Partial response of solar urticaria to omalizumab therapy].

    Science.gov (United States)

    Kowalzick, L; Thiel, W; C Bielfeld; Ziegler, H; Eickenscheidt, L

    2017-06-01

    The treatment of solar urticaria is regarded as difficult. In some cases good responses to the anti-IgE antibody omalizumab (Xolair®), approved for treatment of chronic spontaneous urticaria, have been reported. We report on a 50-year-old Caucasian woman who for the last 5 years has developed localized itching and stinging erythemas following exposure to sunlight accompanied sometimes by anaphylactic reactions. Oral antihistamines in three- to four-fold doses and a topical sun screen had been only partially effective in long-term use. Positive immediate-type reactions with whealing appeared in phototesting with low doses of UVB and UVA. Three weeks after s. c. injection of 300 mg omalizumab, the minimal urticarial dose (MUD) for UVB was increased at least 20-fold (from omalizumab administration to 14 points in weeks two and three. Overall, a partial response of solar urticaria to omalizumab therapy could be observed in the present case.

  6. Partial agonist therapy in schizophrenia: relevance to diminished criminal responsibility.

    Science.gov (United States)

    Gavaudan, Gilles; Magalon, David; Cohen, Julien; Lançon, Christophe; Léonetti, Georges; Pélissier-Alicot, Anne-Laure

    2010-11-01

    Pathological gambling (PG), classified in the DSM-IV among impulse control disorders, is defined as inappropriate, persistent gaming for money with serious personal, family, and social consequences. Offenses are frequently committed to obtain money for gambling. Pathological gambling, a planned and structured behavioral disorder, has often been described as a complication of dopamine agonist treatment in patients with Parkinson's disease. It has never been described in patients with schizophrenia receiving dopamine agonists. We present two patients with schizophrenia, previously treated with antipsychotic drugs without any suggestion of PG, who a short time after starting aripiprazole, a dopamine partial agonist, developed PG and criminal behavior, which totally resolved when aripiprazole was discontinued. Based on recent advances in research on PG and adverse drug reactions to dopamine agonists in Parkinson's disease, we postulate a link between aripiprazole and PG in both our patients with schizophrenia and raise the question of criminal responsibility. © 2010 American Academy of Forensic Sciences.

  7. Experience gained in the management of radioactive waste from maintenance, decontamination and partial decommissioning of a reprocessing plant and conclusions resulting for the management of radioactive wastes from nuclear power plants

    International Nuclear Information System (INIS)

    Hild, W.

    1983-01-01

    After a short description of the historical background of Eurochemic, its main tasks and the various operational phases, a detailed description of the waste management principles applied is presented. The practical experience in the waste treatment is reported for both the operational phase of the reprocessing plant and its decontamination and partial decommissioning after shutdown. Based on this experience and the presented data, an assessment of the practical operations is made and conclusions are drawn. Finally, recommendations are formulated both for the general waste management policy and the practical waste treatment processes in nuclear power reactors. (author)

  8. Conclusion: Challenge and policy response.

    NARCIS (Netherlands)

    Ashworth, G.J.; Dietvorst, A.G.J.

    1995-01-01

    In this final chapter, the editors provide a justification for the pursuit of the approach of the book as a whole by drawing together the specific studies of tourism in particular types of place. They present an integral approach to planning and management for tourism and recreation.

  9. Response of horizontal magnetic field variation to partial counter electrojet

    International Nuclear Information System (INIS)

    Mukunda Rao, M.; Alamelu, V.

    1985-01-01

    The partial counter electrojet events seen through backscatter observations are examined in terms of the parameter ΔH'sub(CEJ)=(Hsub(equator)-Hsub(low lat.))sub(CEJday)-(Hsub(equator)-Hsub(low lat.))sub(mean 1Qday). It is found that the parameter indicates most of the changes in the electrojet observed through the backscatter observations. (author)

  10. Effect of partially purified fumonisins on cellular immune response in ...

    African Journals Online (AJOL)

    After 7 days, cellular immune response was evaluated by delayed-type hypersensitivity (DTH) and lymphoproliferative assays (LA) using spleen cells. Nitric oxide (NO) production by spleen cells was also evaluated. The specific LA response to Pb antigen was higher in group PB than in FB and CTR groups (p< 0.05) but not ...

  11. Effects of partial reinforcement and time between reinforced trials on terminal response rate in pigeon autoshaping.

    Science.gov (United States)

    Gottlieb, Daniel A

    2006-03-01

    Partial reinforcement often leads to asymptotically higher rates of responding and number of trials with a response than does continuous reinforcement in pigeon autoshaping. However, comparisons typically involve a partial reinforcement schedule that differs from the continuous reinforcement schedule in both time between reinforced trials and probability of reinforcement. Two experiments examined the relative contributions of these two manipulations to asymptotic response rate. Results suggest that the greater responding previously seen with partial reinforcement is primarily due to differential probability of reinforcement and not differential time between reinforced trials. Further, once established, differences in responding are resistant to a change in stimulus and contingency. Secondary response theories of autoshaped responding (theories that posit additional response-augmenting or response-attenuating mechanisms specific to partial or continuous reinforcement) cannot fully accommodate the current body of data. It is suggested that researchers who study pigeon autoshaping train animals on a common task prior to training them under different conditions.

  12. Gabapentin adjunctive to risperidone or olanzapine in partially responsive schizophrenia: an open-label pilot study

    Directory of Open Access Journals (Sweden)

    Adel Gabriel

    2010-10-01

    Full Text Available Adel GabrielDepartments of Psychiatry and Community Health Sciences, University of Calgary, Alberta, CanadaBackground: There is a great need in the treatment of schizophrenia for a drug, or drug ­combinations, to improve clinical response with fewer serious side effects. The objective of this study was to explore the therapeutic effects and tolerability of the anticonvulsant gabapentin as an adjunctive in the treatment of patients with partially responsive schizophrenia.Methods: Ten consenting patients with a confirmed Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision diagnosis of schizophrenia were identified. All patients failed at least one 12-week treatment trial with risperidone or olanzapine. Gabapentin was added to ongoing antipsychotic treatment with olanzapine or risperidone for eight weeks. The primary outcome measure was the Positive and Negative Syndrome Scale (PANSS. Other scales included the Calgary Depression Scale (CDSS and the Abnormal Involuntary Movement Scale (AIMS. Repeated-measures multivariate analysis of variance was utilized to examine changes in outcome measures over time with adjunctive treatment with gabapentin.Results: There was a significant drop in the PANSS and CDSS scores at endpoint (week 8. There were no significant differences between the two treatment groups with regard to changes in all outcome measures or in AIMS score. The adjunctive treatments were well tolerated and side effects were transient.Conclusion: Gabapentin could be used successfully as an adjunct to novel antipsychotics in partially responsive schizophrenia. However, large controlled studies are needed to examine the effectiveness of gabapentin in psychotic disorders.Keywords: schizophrenia, refractory, adjunctive treatment, gabapentin, risperidone, olanzapine

  13. Pregabalin versus gabapentin in partial epilepsy: a meta-analysis of dose-response relationships

    Directory of Open Access Journals (Sweden)

    Thompson Sally

    2010-11-01

    Full Text Available Abstract Background To compare the efficacy of pregabalin and gabapentin at comparable effective dose levels in patients with refractory partial epilepsy. Methods Eight randomized placebo controlled trials investigating the efficacy of pregabalin (4 studies and gabapentin (4 studies over 12 weeks were identified with a systematic literature search. The endpoints of interest were "responder rate" (where response was defined as at least a 50% reduction from baseline in the number of seizures and "change from baseline in seizure-free days over the last 28 days (SFD". Results of all trials were analyzed using an indirect comparison approach with placebo as the common comparator. The base-case analysis used the intention-to-treat last observation carried forward method. Two sensitivity analyses were conducted among completer and responder populations. Results The base-case analysis revealed statistically significant differences in response rate in favor of pregabalin 300 mg versus gabapentin 1200 mg (odds ratio, 1.82; 95% confidence interval, 1.02, 3.25 and pregabalin 600 mg versus gabapentin 1800 mg (odds ratio, 2.52; 95% confidence interval, 1.21, 5.27. Both sensitivity analyses supported the findings of the base-case analysis, although statistical significance was not demonstrated. All dose levels of pregabalin (150 mg to 600 mg were more efficacious than corresponding dosages of gabapentin (900 mg to 2400 mg in terms of SFD over the last 28 days. Conclusion In patients with refractory partial epilepsy, pregabalin is likely to be more effective than gabapentin at comparable effective doses, based on clinical response and the number of SFD.

  14. Complete and Partial Organizing for Corporate Social Responsibility

    NARCIS (Netherlands)

    Rasche, A.; de Bakker, F.G.A.; Moon, J.

    2013-01-01

    This paper investigates different modes of organizing for corporate social responsibility (CSR). Based on insights from organization theory, we theorize two ways to organize for CSR. "Complete" organization for CSR happens within businesses and depends on the availability of certain organizational

  15. Complete and Partial Organizing for Corporate Social Responsibility

    DEFF Research Database (Denmark)

    Rasche, Andreas; de Bakker, Frank; Moon, Jeremy

    2013-01-01

    This paper investigates different modes of organizing for corporate social responsibility (CSR). Based on insights from organization theory, we theorize two ways to organize for CSR. 'Complete' organization for CSR happens within businesses and depends on the availability of certain organizationa...

  16. Relationship Between Partial and Total Responses to Advertising with Application to U.S. Meats

    OpenAIRE

    Kinnucan, Henry W.; Myrland, Oystein

    2002-01-01

    Buse’s concept of total response is extended to advertising effects. Results suggest that partial advertising elasticities overstate advertising’s ability to increase market demand. One implication is that advertising bans (e.g., for alcohol and tobacco) are apt to be less effective than indicated by partial advertising elasticities estimated from econometric models. Extending the concept of total response to price effects, the total advertising “flexibility” sets the lower bound on the optim...

  17. Summary and Conclusions

    International Nuclear Information System (INIS)

    2013-01-01

    This section summarizes the presentations and Panel discussions of the 4 technical sessions of the workshop: 1 - Regulatory cooperation on generic and design specific issues, MDEP working groups (EPR, AP1000), vendor inspection co-operation, digital I and C, and codes and standards (7 presentations); 2 - Regulatory positions on siting practices and enhancements as a result of lessons learned from Fukushima accident (5 presentations); 3 - Construction experience and regulatory oversight of new reactor construction activities (6 presentations); 4 - Lessons learned from regulatory licensing reviews of new reactor designs (6 presentations). The main workshop conclusions are listed as follows: - Harmonization is a long term goal and significant progress has been made. However, this long term objective needs to be associated with short term measurable steps; - MDEP approach to tackle on one side with specific technical subjects, and to strive harmonisation on generic topics was considered appropriate; - Convergence on technical requirements is more realistic than harmonization of codes and standard; - Beneficial early engagement of different stakeholders specially at the siting stage has been acknowledged; - Need to characterise the hazards and to keep updated the safety assessment (PSR); - Land use issues are important particularly after Fukushima; - Commissioning aspects (e.g. training aspects for inspectors) should be addressed by WGRNR taking into account MDEP interaction; - Importance of WGRNR ConEx Programme: construction experience sharing is a leverage for quality and so for a future safe operation of NPPs; - Capability of licensee to follow the responsibility of design changes (could be an issue for small utilities); - Importance of Periodic Safety Reviews to review and account for the design. Finally, the WGRNR has convened that a third conference should be held in about two years time (2014- 2015)

  18. Response of partially premixed flames to acoustic velocity and equivalence ratio perturbations

    Energy Technology Data Exchange (ETDEWEB)

    Kim, K.T.; Lee, J.G.; Quay, B.D.; Santavicca, D.A. [Center for Advanced Power Generation, Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, University Park, PA (United States)

    2010-09-15

    This article describes an experimental investigation of the forced response of a swirl-stabilized partially premixed flame when it is subjected to acoustic velocity and equivalence ratio fluctuations. The flame's response is analyzed using phase-resolved CH{sup *} chemiluminescence images and flame transfer function (FTF) measurements, and compared with the response of a perfectly premixed flame under acoustic perturbations. The nonlinear response of the partially premixed flame is manifested by a partial extinction of the reaction zone, leading to rapid reduction of flame surface area. This nonlinearity, however, is observed only when the phase difference between the acoustic velocity and the equivalence ratio at the combustor inlet is close to zero. The condition, {delta}{phi}{sub {phi}}'-V'{approx}0 , indicates that reactant mixtures with high equivalence ratio impinge on the flame front with high velocity, inducing large fluctuations of the rate of heat release. It is found that the phase difference between the acoustic velocity and equivalence ratio nonuniformities is a key parameter governing the linear/nonlinear response of a partially premixed flame, and it is a function of modulation frequency, inlet velocity, fuel injection location, and fuel injector impedance. The results presented in this article will provide insight into the response of a partially premixed flame, which has not been well explored to date. (author)

  19. A Comparison of Graded Response and Rasch Partial Credit Models with Subjective Well-Being.

    Science.gov (United States)

    Baker, John G.; Rounds, James B.; Zevon, Michael A.

    2000-01-01

    Compared two multiple category item response theory models using a data set of 52 mood terms with 713 undergraduate psychology students. Comparative model fit for the Samejima (F. Samejima, 1966) logistic model for graded responses and the Masters (G. Masters, 1982) partial credit model favored the former model for this data set. (SLD)

  20. Plasma Catecholamines, Sweat Electrolytes and Physiological Responses of Exercised Normal, Partial Anhidrotic and Anhidrotic Horses

    OpenAIRE

    A. Bashir; A. Rasedee

    2009-01-01

    Problem statement: Malaysia imports horses from temperate countries to develop equine sports in the country. Several of these horses developed partial and complete anhidrosis. Approach: Normal, partial anhidrotic and anhidrotic horses were exercised to determine their sweating and physiological responses to exercise. The heart and respiratory rates, rectal temperature and blood samples were obtained before the horses were lunged at 10 km h-­1 for 1 h and at again at 15, 30, 45, 60 min and 24 ...

  1. Item and response-category functioning of the Persian version of the KIDSCREEN-27: Rasch partial credit model

    Directory of Open Access Journals (Sweden)

    Jafari Peyman

    2012-10-01

    Full Text Available Abstract Background The purpose of the study was to determine whether the Persian version of the KIDSCREEN-27 has the optimal number of response category to measure health-related quality of life (HRQoL in children and adolescents. Moreover, we aimed to determine if all the items contributed adequately to their own domain. Findings The Persian version of the KIDSCREEN-27 was completed by 1083 school children and 1070 of their parents. The Rasch partial credit model (PCM was used to investigate item statistics and ordering of response categories. The PCM showed that no item was misfitting. The PCM also revealed that, successive response categories for all items were located in the expected order except for category 1 in self- and proxy-reports. Conclusions Although Rasch analysis confirms that all the items belong to their own underlying construct, response categories should be reorganized and evaluated in further studies, especially in children with chronic conditions.

  2. General conclusions on workshop

    International Nuclear Information System (INIS)

    Rustand, H.

    2006-01-01

    The author proposes a general conclusion on the second workshop on the indemnification of damage in the event of a nuclear accident, organized in Bratislava, the 18-20 May 2005. He pointed out the most important discussions and the results revealed during these two days. (A.L.B.)

  3. Conclusions and recommendations

    International Nuclear Information System (INIS)

    1984-01-01

    The FAO/IAEA/GSF/SIDA Co-ordinated Research Programme on Cereal Grain Protein Improvement by Nuclear Techniques was a follow-up to the FAO/IAEA/GSF Co-ordinated Research Programme on the Use of Nuclear Techniques for Seed Protein Improvement. It was initiated in 1969 and ended in 1981. The objectives of the meeting were to review and evaluate the achievements of the current and previous programmes in order to draw conclusions on the possibility of genetic improvement of cereal grain protein using nuclear techniques, to identify unsolved problems and to discuss and propose possible approaches for their solution. Through reviews and discussions, conclusions and recommendations were made by the participants

  4. In Vivo-Expressed Proteins of Virulent Leptospira interrogans Serovar Autumnalis N2 Elicit Strong IgM Responses of Value in Conclusive Diagnosis.

    Science.gov (United States)

    Raja, Veerapandian; Shanmughapriya, Santhanam; Kanagavel, Murugesan; Artiushin, Sergey C; Velineni, Sridhar; Timoney, John F; Natarajaseenivasan, Kalimuthusamy

    2016-01-01

    Leptospirosis is a serious zoonosis that is underdiagnosed because of limited access to laboratory facilities in Southeast Asia, Central and South America, and Oceania. Timely diagnosis of locally distributed serovars of high virulence is crucial for successful care and outbreak management. Using pooled patient sera, an expression gene library of a virulent Leptospira interrogans serovar Autumnalis strain N2 isolated in South India was screened. The identified genes were characterized, and the purified recombinant proteins were used as antigens in IgM enzyme-linked immunosorbent assay (ELISA) either singly or in combination. Sera (n = 118) from cases of acute leptospirosis along with sera (n = 58) from healthy subjects were tested for reactivity with the identified proteins in an ELISA designed to detect specific IgM responses. We have identified nine immunoreactive proteins, ArgC, RecA, GlpF, FliD, TrmD, RplS, RnhB, Lp28.6, and Lrr44.9, which were found to be highly conserved among pathogenic leptospires. Apparently, the proteins ArgC, RecA, GlpF, FliD, TrmD, and Lrr44.9 are expressed during natural infection of the host and undetectable in in vitro cultures. Among all the recombinant proteins used as antigens in IgM ELISA, ArgC had the highest sensitivity and specificity, 89.8% and 95.5%, respectively, for the conclusive diagnosis of leptospirosis. The use of ArgC and RecA in combination for IgM ELISA increased the sensitivity and specificity to 95.7% and 94.9%, respectively. ArgC and RecA thus elicited specific IgM responses and were therefore effective in laboratory confirmation of Leptospira infection. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  5. Conclusions [Chapter 15

    Science.gov (United States)

    Joanne J. Ho; David L. Peterson; Natalie J. Little

    2018-01-01

    The Intermountain Adaptation Partnership (IAP) provided significant contributions to assist climate change response in national forests and national parks of the region. The effort synthesized the best available scientific information to assess climate change vulnerability, develop adaptation options, and catalyze a collaboration of land management agencies and...

  6. Conclusions [Chapter 13

    Science.gov (United States)

    S. Karen Dante-Wood; Linh Hoang

    2018-01-01

    The Northern Rockies Adaptation Partnership (NRAP) provided significant contributions to assist climate change response in national forests and national parks of the Northern Rockies region. The effort synthesized the best available scientific information to assess climate change vulnerability, develop adaptation options, and catalyze a collaboration of land management...

  7. 7. Conclusions and reflections

    OpenAIRE

    Nettle, Daniel

    2016-01-01

    But now your eyes sing the sad, sad song,Of how you lived so fast and died so young. Introduction We’ve now finished the data chapters of this book, and some conclusions are in order. In this chapter, I summarise what strike me as the main things we have learned, and suggest what their implications might be. I then devote a more extended discussion to the issue of causes of patterns of social behaviour, and how our data might bear on it. From this follows a brief consideration of what kinds o...

  8. The Dif Identification in Constructed Response Items Using Partial Credit Model

    OpenAIRE

    Heri Retnawati

    2017-01-01

    The study was to identify the load, the type and the significance of differential item functioning (DIF) in constructed response item using the partial credit model (PCM). The data in the study were the students’ instruments and the students’ responses toward the PISA-like test items that had been completed by 386 ninth grade students and 460 tenth grade students who had been about 15 years old in the Province of Yogyakarta Special Region in Indonesia. The analysis toward the item characteris...

  9. Conclusions and recommendations

    International Nuclear Information System (INIS)

    Carrette, M.

    1997-01-01

    The paper presents conclusions and recommendations at the closing session of the NEA/OECD Workshop held at Fontenay-aux-Roses on 12-14 June 1995. The conclusions refer to issues like: public reaction to foodstuffs containing radioisotope concentrations under the danger standards, possible non-adherence of manufacturers, processors, distributors, et al, to the instructions and guidance from radiation protection specialists, integration of all the food chain factors in the elaboration of the emergency intervention programs, etc. Among the most significant recommendations the following may be mentioned: 1. Differences between different intervention levels and the maximum admissible levels agreed upon by national, regional or international nutrition authorities should be further studied; 2. Problems created by the Chernobyl accident (as for instance, the methods of treatment of food chain products containing unacceptable radioactivity concentrations) are still present and must be solved; 3. Further studies should be done on the socio-cultural aspects of the communication, particularly on the information in rural environment; 4. The preventive measures in agriculture should be implemented as rapidly as possible; 5. In elaborating programmes of agriculture countermeasures, the management of contaminated media, particularly, of forests and their effect on agriculture

  10. Chernobyl - facts and conclusions

    Energy Technology Data Exchange (ETDEWEB)

    Schlaefer, H

    1986-07-01

    The article summarizes and comments on the activities started in the FRG after the Chernobyl MCA, and tries to assess whether the legal provisions currently applicable, or emergency plans available, are apt to efficiently cope with such an emergency situation. The author discusses the Soviet Union's initial efforts towards minimizing the disastrous significance of events, the lack of preparedness of German authorities and provisions, the non-availability of persons responsible during weekends and night hours, the confounding mess of measured data and units published by the information media and authorities, and the lack of a suitable information scheme and infrastructure supported both by the Land governments and the Federal Government. (HSCH).

  11. Dielectric response of fully and partially depleted ferroelectric thin films and inversion of the thickness effect

    International Nuclear Information System (INIS)

    Misirlioglu, I B; Yildiz, M

    2013-01-01

    We study the effect of full and partial depletion on the dielectric response characteristics of ferroelectric thin films with impurities via a computational approach. Using a thermodynamic approach along with the fundamental equations for semiconductors, we show that films with partial depletion display unique features and an enhanced dielectric response compared with those fully depleted. We find that the capacitance peak at switching can be significantly suppressed in the case of high impurity densities (>10 25 m −3 ) with relatively low ionization energy, of the order of 0.5 eV. For conserved number of species in films, electromigration of ionized impurities at room temperature is negligible and has nearly no effect on the dielectric response. In films with high impurity density, the dielectric response at zero bias is enhanced with respect to charge-free films or those with relatively low impurity density ( 24 m −3 ). We demonstrate that partially depleted films should be expected to exhibit peculiar capacitance–voltage characteristics at low and high bias and that the thickness effect probed in experiments in ferroelectric thin films could be entirely inverted in thin films with depletion charges where a higher dielectric response can be measured in thicker films. Therefore, depletion charge densities in ferroelectric thin films should be estimated before size-effect-related studies. Finally, we noted that these findings are in good qualitative agreement with dielectric measurements carried out on PbZr x Ti 1−x O 3 . (paper)

  12. Note: Nonpolar solute partial molar volume response to attractive interactions with water.

    Science.gov (United States)

    Williams, Steven M; Ashbaugh, Henry S

    2014-01-07

    The impact of attractive interactions on the partial molar volumes of methane-like solutes in water is characterized using molecular simulations. Attractions account for a significant 20% volume drop between a repulsive Weeks-Chandler-Andersen and full Lennard-Jones description of methane interactions. The response of the volume to interaction perturbations is characterized by linear fits to our simulations and a rigorous statistical thermodynamic expression for the derivative of the volume to increasing attractions. While a weak non-linear response is observed, an average effective slope accurately captures the volume decrease. This response, however, is anticipated to become more non-linear with increasing solute size.

  13. Note: Nonpolar solute partial molar volume response to attractive interactions with water

    Energy Technology Data Exchange (ETDEWEB)

    Williams, Steven M.; Ashbaugh, Henry S., E-mail: hanka@tulane.edu [Department of Chemical and Biomolecular Engineering, Tulane University, New Orleans, Louisiana 70118 (United States)

    2014-01-07

    The impact of attractive interactions on the partial molar volumes of methane-like solutes in water is characterized using molecular simulations. Attractions account for a significant 20% volume drop between a repulsive Weeks-Chandler-Andersen and full Lennard-Jones description of methane interactions. The response of the volume to interaction perturbations is characterized by linear fits to our simulations and a rigorous statistical thermodynamic expression for the derivative of the volume to increasing attractions. While a weak non-linear response is observed, an average effective slope accurately captures the volume decrease. This response, however, is anticipated to become more non-linear with increasing solute size.

  14. Prospects and conclusion

    International Nuclear Information System (INIS)

    1994-01-01

    The present issue of 'Les Cahiers de COGEMAGAZINE', dedicated to role played by Cogema in the nuclear fuel cycling, ends with a short account on perspectives and concluding considerations. In the world nuclear fuel industry the most active zones appear to be France, Japan, China, Taiwan and Korea. A real expansion is to be expected in UO 2 market for PWRs. Also rapid development will be recorded by the production of MOF (mixed oxide fuels) especially due to the inception of British reprocessing plant at Thorp and the increase of number of MOF-fuelled reactors. The most significant lines of progress related to the new fuels are estimated to be: high burn-up (by increasing the resistance to fission gas pressure and irradiation), improvement of response to power excursions, fuel matrices of stronger retention, increase in the plutonium content of MOF, 100% MOF-fuelled reactors, optimizing the utilization of consumable poisons (for PWR) and very high burn-up and very long service lifetimes (for Breeders). In a nuclear environment, now in a rather low expansion rate, the French nuclear fuel industry enjoys the benefit of: an important national market, industrial experimented teams able to tackle all the steps from design to realization of a diversity of nuclear fuel types, fabrication facilities combining suppleness to clients' demands with requirements for high quality, a highly-rated worldwide position, and important capabilities of technological further development. An annex is added showing the percentage involvement of COGEMA and FRAMATOME in the fields of UO 2 -PuO 2 fuel production for PWR, fuels for Breeder, WER and experimental reactors and transport. Also participation of other European companies like PECHINEY, BELGONUCLEAIRE and SIEMENS is indicated

  15. Summary and conclusions

    International Nuclear Information System (INIS)

    2011-01-01

    authorities, reactor designers, and operators/ licensees perspectives on the various practices used in the regulation of nuclear power plant siting (selection, evaluation and site preparation). This session was also aimed to address issues on sites where a mixture of activities are taking place (e.g., operating units, new construction, decommissioning, etc.) including organisation of the regulators and licensee/engineering organisation, methods, systems, etc. Conclusions: In general workshop participants agreed on the need to regularly have these kind of forums to discuss relevant regulatory issues for new builds. One important aspect of this workshop was the participation of 'New Entrants'. The interaction between NEA member countries with mature nuclear power plants and newcomers was quite important since it gave newcomers the possibility to benefit of mature international practices in order to focus their regulatory oversight and control. NEA members could also benefit from insights the New Entrants discover as they develop or enhance their regulatory controls. In addition technical exchanges associated with construction experience of New Entrants as they begin to license, build and operate NPP could benefit NEA members

  16. Microstrip linear phase low pass filter based on defected ground structures for partial response modulation

    DEFF Research Database (Denmark)

    Cimoli, Bruno; Johansen, Tom Keinicke; Olmos, Juan Jose Vegas

    2018-01-01

    We report a high performance linear phase low pass filter (LPF) designed for partial response (PR) modulations. For the implementation, we adopted microstrip technology and a variant of the standard stepped‐impedance technique. Defected ground structures (DGS) are used for increasing the characte......We report a high performance linear phase low pass filter (LPF) designed for partial response (PR) modulations. For the implementation, we adopted microstrip technology and a variant of the standard stepped‐impedance technique. Defected ground structures (DGS) are used for increasing...... the characteristic impedance of transmission lines. Experimental results prove that the proposed filter can successfully modulate a non‐return‐to‐zero (NRZ) signal into a five levels PR one....

  17. LDPC code decoding adapted to the precoded partial response magnetic recording channels

    International Nuclear Information System (INIS)

    Lee, Jun; Kim, Kyuyong; Lee, Jaejin; Yang, Gijoo

    2004-01-01

    We propose a signal processing technique using LDPC (low-density parity-check) code instead of PRML (partial response maximum likelihood) system for the longitudinal magnetic recording channel. The scheme is designed by the precoder admitting level detection at the receiver-end and modifying the likelihood function for LDPC code decoding. The scheme can be collaborated with other decoder for turbo-like systems. The proposed algorithm can contribute to improve the performance of the conventional turbo-like systems

  18. LDPC code decoding adapted to the precoded partial response magnetic recording channels

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jun E-mail: leejun28@sait.samsung.co.kr; Kim, Kyuyong; Lee, Jaejin; Yang, Gijoo

    2004-05-01

    We propose a signal processing technique using LDPC (low-density parity-check) code instead of PRML (partial response maximum likelihood) system for the longitudinal magnetic recording channel. The scheme is designed by the precoder admitting level detection at the receiver-end and modifying the likelihood function for LDPC code decoding. The scheme can be collaborated with other decoder for turbo-like systems. The proposed algorithm can contribute to improve the performance of the conventional turbo-like systems.

  19. Conclusions

    Indian Academy of Sciences (India)

    In long-term better adapted varieties are needed to adapt to multiple stresses linked with climate change. ... and water management are available which can help minimize negative impacts. ... Adaptation practices take time to become effective.

  20. Conclusion

    NARCIS (Netherlands)

    Grignon, F.; Mazrui, A.; Rutten, M.M.E.M.; Rutten, M.M.E.M.; Mazrui, A.; Grignon, F.

    2001-01-01

    The outcome of a three-day conference held at the African Studies Centre, Leiden, The Netherlands, in September 1998, this book on the 1997 Kenya general elections is organized in four parts: the direct pre-electoral background; technical and national analysis of the general elections, including the

  1. Conclusion

    OpenAIRE

    Rainhorn, Jean-Daniel; Boudamoussi, Samira El

    2017-01-01

    “Science without conscience is but the ruin of the soul.”—François Rabelais, 1542 A special feature of this book is to bring together the work of researchers coming from different disciplines and having various themes of reflection or practices in the field of biomedicine. While the general trend of science goes towards increasing specialization, the project of this book is to look at the use of medical advances in a transversal perspective. In other words, it intends to highlight what unregu...

  2. Conclusions

    International Nuclear Information System (INIS)

    Mandil, C.

    1994-01-01

    The renewable energies and the nuclear one are complementary. They belong to the french energy policy, which has three aims: strategic, economic and environmental. They contribute to the diversification of the energy balance and to the energy competitiveness. Energy savings might be achieved and renewable energies might be developed for the future

  3. Conclusions

    Indian Academy of Sciences (India)

    Confounding effect of obesity and associated co-morbidities (especially on metabolic abnormalities, cardiovascular and cerebrovascular morbidity) should be clearly dissected out in future studies ...

  4. Conclusion

    OpenAIRE

    Houmed Soulé, Aramis

    2018-01-01

    Au cours de son règne qui a duré plus d’une quarantaine d’années, en une période cruciale de l’histoire de la Corne de l’Afrique, Maḥammad Ḥanfaré parvient à préserver son sultanat, à défaut de l’ensemble du pays ‘Afar, des visées impérialistes d’où qu’elles viennent. Malheureusement, l’indépendance de cette entité politique ‘Afar ne lui survit pas, du moins sur le plan international. Des luttes fratricides pour sa succession qui opposent ses nombreux héritiers et dont les prémices apparaisse...

  5. Conclusion

    DEFF Research Database (Denmark)

    Fahnøe, Kristian Relsted; Warming, Hanne

    2017-01-01

    analysis approach reveal how clients’ struggles in intimate and societal life, and in public and private spaces, are intertwined with geo-politics and global flows of governance strategies, e.g. neoliberalism and managerialism, which also condition social work practices. Indeed, social work constitutes......Fahnøe and Warming provide a cogent overview of how a lived citizenship approach enables critical analyses of social work and social policies by addressing challenges related to rights, recognition, participation, belonging and identity. The sub-concept of intimate citizenship and a spatial...... a kind of sociological magnifying glass through which broader social changes can be studied, including dynamics of inclusion and exclusion, new conflicts and modes of resistance, and new social pathologies....

  6. Conclusion

    DEFF Research Database (Denmark)

    Warming, Hanne; Fahnøe, Kristian

    2017-01-01

    analysis approach reveal how clients’ struggles in intimate and societal life, and in public and private spaces, are intertwined with geo-politics and global flows of governance strategies, e.g. neoliberalism and managerialism, which also condition social work practices. Indeed, social work constitutes......Warming and Fahnøe provide a cogent overview of how a lived citizenship approach enables critical analyses of social work and social policies by addressing challenges related to rights, recognition, participation, belonging and identity. The sub-concept of intimate citizenship and a spatial...... a kind of sociological magnifying glass through which broader social changes can be studied, including dynamics of inclusion and exclusion, new conflicts and modes of resistance, and new social pathologies....

  7. Conclusion

    DEFF Research Database (Denmark)

    de Vreese, Claes; Reinemann, Carsten; Esser, Frank

    2017-01-01

    At the outset, we asked if there is any good news about the news and, if so, where the good news is. In academic research and public discussions about news and democracy, one fi nds different interpretations of the state of current news provision. A tendency towards pessimism about current news...... is seen as having a negative impact on the quality of political life and democracy. Set against the pessimism and caution in the public debate and literature on news quality and the performance of political journalism, we were not optimistic that we would fi nd good-quality news or that we would be able...... to offer some good news as a positive antidote, so to speak, to the pervasive pessimism in the literature....

  8. Conclusions

    International Nuclear Information System (INIS)

    Brookes, L.G.; Motamen, H.

    1984-01-01

    The paper covers the following: economics of nuclear power; nuclear or fossil-fuel plants; power systems; methods of capital investment appraisal; size factor; nuclear industry; uranium demand; fuel cycle; fast reactors; choice of reactors; case studies from France; power plants in USA and West Germany; electricity tariffs; nuclear energy in Middle Eastern states; energy growth and economic growth; nuclear energy as macroeconomic influence; future energy options. (U.K.)

  9. Conclusion

    DEFF Research Database (Denmark)

    Jørgensen, Christian Helms; Wallo, Andreas; Toiviainen, Hanna

    2015-01-01

    Work in times of globalisation and uncertainty is undergoing considerable changes, which has strengthened the importance of work as a site of learning. New trends in production, such as digitalisation, challenge traditional modes of producing goods and services. Emerging forms of flexible...... production and knowledge-work offer growing learning opportunities to people throughout their active working life. In contrast to the stable and standardised modes of Fordist production, modern working life is characterised by rapid changes and employees interacting across globally distributed professional...... explores the challenges of working and learning on the boundaries between education and working life. Globalisation affects the transition patterns from vocational education to the labour market in many ways (Schoon & Silbereisen, 2009), even though the specific challenges to national-level policies vary...

  10. Conclusions

    Science.gov (United States)

    Ahonen, Pasi; Alahuhta, Petteri; Daskala, Barbara; Delaitre, Sabine; Hert, Paul De; Lindner, Ralf; Maghiros, Ioannis; Moscibroda, Anna; Schreurs, Wim; Verlinden, Michiel

    Some say that an increase in security does not necessarily mean a further encroachment on privacy - indeed, security is necessary to protect personal data and our privacy. Networks must be secure, our personal devices, reliable, dependable and trustworthy. But security is a multifaceted term, with many dimensions. We are of the view that an increase in security most likely will encroach upon our privacy in an ambient intelligence world. Surveillance cameras will continue to proliferate. We assume that, whatever the law is, whatever privacy protections government and business say they honour, our telecommunications, e-mails and Internet usage will be monitored to an increasing degree. The same will be true of our interfaces with the world of ambient intelligence.

  11. Conclusions

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. First study on fHSC. First study on fHSC. fHSC exhibit embryonic stem cell like properties. fHSC therapy results in myocardial regeneration in rat model of MI. fHSC may be a novel stem cell type for cardiovascular regeneration.

  12. Conclusion

    International Nuclear Information System (INIS)

    2000-01-01

    In the monograph peculiarities of radioinduced sexual dysfunctions of Chernobyl accident liquidators are described. It is shown, that ones of principal clinical manifestations of stochastic radio-genetic effects are sexual dysfunctions. Assessment in point of view of stages and components of copulative cycle is carried out. Authors made attempt to take in account all involved in sexual dysfunctions systems for examined contingent. It is noted, that genesis of radioinduced sexual dysfunctions is complex and it includes both the influence of vegetative nervous system damage and the direct damage of gonads. During clinical examination with patients it is revealed that both vegetative-vascular dysfunctions and asteno-neurotic dysfunctions are dominating. Authors noting that mentioned sexual dysfunctions are caused by low dose irradiation, and they have certain distinctions. Measures for comprehensive rehabilitation of suffered contingent in late period after irradiation are developed

  13. Conclusions

    Indian Academy of Sciences (India)

    Microbial organisms play a major role in assimilation of P from the water column and also from the interstitial waters. Mineralisation of microbial bodies is a very rapid process and autophosphatization may occur within few hours or days after death. Geo-microbiology is an important subject and needs to be developed.

  14. Conclusion

    International Nuclear Information System (INIS)

    Timofeev, Yu.M.; Zikiryakhodjaev, D.Z.

    1997-01-01

    In this chapter of book authors made following summary: the cancerous growths of anal canal is rare form of growths; extension of anal canal depends from sex, age, weight and growth of patient; the developed schemes of classification and staging of cancerous growths of anal canal have important role for growths systematization; typical symptoms are blood in excrement, pains in anus, presence of swelling in anus, the treatment of the cancerous growths of anal canal must be varied

  15. Photosynthesis and growth response of almond to increased atmospheric ozone partial pressures

    Energy Technology Data Exchange (ETDEWEB)

    Retzlaff, W.A.; Williams, L.E. (Univ. of California, Davis (United States) Kearney Agricultural Center, Parlier, CA (United States)); DeJong, T.M. (Univ. of California, Davis (United States))

    Uniform nursery stock of five almond cultivars [Prunus dulcis (Mill) D.A. Webb syn. P. amygdalus Batsch, cv. Butte, Carmel, Mission, Nonpareil, and Sonora] propagated on peach (P. domstica L. Batsch.) rootstock were exposed to three different atmospheric ozone (O[sub 3]) partial pressures. The trees were planted in open-top fumigation chambers on 19 Apr. 1989 at the University of California Kearny Agricultural Center located in the San Joaquin Valley of California. Exposures of the trees to three atmospheric O[sub 3] partial pressures lasted from 1 June to 2 Nov. 1989. The mean 12-h [0800-2000 h Pacific Daylight Time (PDT)] O[sub 3] partial pressures measured in the open-top chambers during the experimental period were 0.038, 0.060, and 0.112 [mu]Pa Pa[sup [minus]1] O[sub 3] in the charcoal filtered, ambient, and ambient + O[sub 3] treatments, respectively. Leaf net CO[sub 2] assimilation, trunk cross-sectional area growth, and root, trunk, foliage, and total dry weight of Nonpareil were reduced by increased atmospheric O[sub 3] partial pressures. Mission was unaffected by O[sub 3] and Butte, Carmel, and Sonora were intermediate in their responses. Foliage of Nonpareil also abscised prematurely in the ambient and ambient + O[sub 3] treatments. The results indicate that there are almond cultivars that are sensitive to O[sub 3] exposure.

  16. Growth responses of Neurospora crassa to increased partial pressures of the noble gases and nitrogen.

    Science.gov (United States)

    Buchheit, R G; Schreiner, H R; Doebbler, G F

    1966-02-01

    Buchheit, R. G. (Union Carbide Corp., Tonawanda, N.Y.), H. R. Schreiner, and G. F. Doebbler. Growth responses of Neurospora crassa to increased partial pressures of the noble gases and nitrogen. J. Bacteriol. 91:622-627. 1966.-Growth rate of the fungus Neurospora crassa depends in part on the nature of metabolically "inert gas" present in its environment. At high partial pressures, the noble gas elements (helium, neon, argon, krypton, and xenon) inhibit growth in the order: Xe > Kr> Ar > Ne > He. Nitrogen (N(2)) closely resembles He in inhibitory effectiveness. Partial pressures required for 50% inhibition of growth were: Xe (0.8 atm), Kr (1.6 atm), Ar (3.8 atm), Ne (35 atm), and He ( approximately 300 atm). With respect to inhibition of growth, the noble gases and N(2) differ qualitatively and quantitatively from the order of effectiveness found with other biological effects, i.e., narcosis, inhibition of insect development, depression of O(2)-dependent radiation sensitivity, and effects on tissue-slice glycolysis and respiration. Partial pressures giving 50% inhibition of N. crassa growth parallel various physical properties (i.e., solubilities, solubility ratios, etc.) of the noble gases. Linear correlation of 50% inhibition pressures to the polarizability and of the logarithm of pressure to the first and second ionization potentials suggests the involvement of weak intermolecular interactions or charge-transfer in the biological activity of the noble gases.

  17. Photosynthesis and growth response of almond to increased atmospheric ozone partial pressures

    International Nuclear Information System (INIS)

    Retzlaff, W.A.; Williams, L.E.; DeJong, T.M.

    1992-01-01

    Uniform nursery stock of five almond cultivars [Prunus dulcis (Mill) D.A. Webb syn. P. amygdalus Batsch, cv. Butte, Carmel, Mission, Nonpareil, and Sonora] propagated on peach (P. domstica L. Batsch.) rootstock were exposed to three different atmospheric ozone (O 3 ) partial pressures. The trees were planted in open-top fumigation chambers on 19 Apr. 1989 at the University of California Kearny Agricultural Center located in the San Joaquin Valley of California. Exposures of the trees to three atmospheric O 3 partial pressures lasted from 1 June to 2 Nov. 1989. The mean 12-h [0800-2000 h Pacific Daylight Time (PDT)] O 3 partial pressures measured in the open-top chambers during the experimental period were 0.038, 0.060, and 0.112 μPa Pa -1 O 3 in the charcoal filtered, ambient, and ambient + O 3 treatments, respectively. Leaf net CO 2 assimilation, trunk cross-sectional area growth, and root, trunk, foliage, and total dry weight of Nonpareil were reduced by increased atmospheric O 3 partial pressures. Mission was unaffected by O 3 and Butte, Carmel, and Sonora were intermediate in their responses. Foliage of Nonpareil also abscised prematurely in the ambient and ambient + O 3 treatments. The results indicate that there are almond cultivars that are sensitive to O 3 exposure

  18. Seismic response of unanchored and partially anchored liquid-storage tanks. Final report

    International Nuclear Information System (INIS)

    Malhotra, P.K.; Veletsos, A.S.

    1995-12-01

    Ground-mounted vertical storage tanks are important components of nuclear plant safety systems. A systematic study is made of the principal effects of base uplifting on the seismic response of laterally excited, unanchored and partially anchored cylindrical liquid-storage tanks. The study consists of two parts: the first deals with the static uplifting resistance of the flexible base plate, and the second deals with the dynamic response of the uplifting system. An insight into the behavior of the uplifting base plate is first gained with the help of a prismatic beam solution. In Section 2, the solution is implemented exactly, whereas in Section 3 it is implemented approximately by use of the Ritz energy procedure. Solutions are next presented for axisymmetrically and asymmetrically uplifted base plate of tanks, in Section 4. For the axisymmetric case the solution is implemented exactly, as well as approximately by modeling the plate by a series of semiinfinite prismatic beams. The accuracy of the latter approach is confirmed by comparing its predictions with those of the former. In Section 5, a highly efficient and rational method is presented for the dynamic response analysis of uplifting tanks. Both unanchored tanks and partially anchored tanks, for which the number of anchor bolts at the base is insufficient to ensure full fixity, are considered. It is shown that base uplifting may reduce significantly the hydrodynamic pressures, but these reductions may be associated with increased axial compressive stresses in the tank wall and large plastic rotations at the plate-shell junction. For partially anchored tanks, energy loss due to bolt yielding is found to be small

  19. Modifications of animal response to Partial Body Hyperthermia (PBH) as a potent radioprotector: Relationships with animal age and sex

    International Nuclear Information System (INIS)

    Alya, G.

    2002-04-01

    Currently available radio protectors are poorly tolerated in man. Thus, the use of the most promising agent, WR 2721 [S-2 (3-aminoprophylamino) ethylphosphoro thioic acid] has been limited due to its poor clinical tolerance. In a search for less toxic and/or without side effects agents, radioprotective effects of partial body hyperthermia (PBH) have been tested on Wistar rats of both sexes at different ages. Groups of male and female rats were irradiated [Total Body Irradiation (TBI)] in a perforated plexi-glass boxes using a 60 Co source. The irradiation dose was 9 Gy which is considered as a lethal dose of 100% of animals (LD 1 00) (the dose rate was = 80-85 rad.min -1 ). Irradiated animals were monitored for 2 weeks at least, and percentage of survival was calculated on the control groups. Partial Body Hyperthermia was carried out 20 hours prior to irradiation of 200-250 gr rats (by immersion of lower parts and legs of rats, in water bath at 43 centigrade for 1 h). Irradiated PBH treated animals were monitored for 30 days after irradiation and the survival percentage was calculated. Our results showed that PBH treatment, can be considered as a radioprotector. Moreover, the results of the undertaken study showed that this response changes as a function of animal age and sex. Thus, PBH was more effective on young rats (males and females), However, after 30 days of irradiation, PBH was more effective on males than females. The conclusion reached by this study is that animal response to PBH decreases with aging. Despite that the precise mechanism by which PBH induces retardation of death and enhance survival of rats is still obscure, Hyperthermia is known to enhance the immune response. Literature reveals that the productions of cytokines such as interferons and interleukins as well as natural killer cell activity are enhanced after hyperthermia. (author)

  20. Partial oxidation of landfill leachate in supercritical water: Optimization by response surface methodology

    International Nuclear Information System (INIS)

    Gong, Yanmeng; Wang, Shuzhong; Xu, Haidong; Guo, Yang; Tang, Xingying

    2015-01-01

    Highlights: • Partial oxidation of landfill leachate in supercritical water was investigated. • The process was optimized by Box–Behnken design and response surface methodology. • GY H2 , TRE and CR could exhibit up to 14.32 mmol·gTOC −1 , 82.54% and 94.56%. • Small amounts of oxidant can decrease the generation of tar and char. - Abstract: To achieve the maximum H 2 yield (GY H2 ), TOC removal rate (TRE) and carbon recovery rate (CR), response surface methodology was applied to optimize the process parameters for supercritical water partial oxidation (SWPO) of landfill leachate in a batch reactor. Quadratic polynomial models for GY H2 , CR and TRE were established with Box–Behnken design. GY H2 , CR and TRE reached up to 14.32 mmol·gTOC −1 , 82.54% and 94.56% under optimum conditions, respectively. TRE was invariably above 91.87%. In contrast, TC removal rate (TR) only changed from 8.76% to 32.98%. Furthermore, carbonate and bicarbonate were the most abundant carbonaceous substances in product, whereas CO 2 and H 2 were the most abundant gaseous products. As a product of nitrogen-containing organics, NH 3 has an important effect on gas composition. The carbon balance cannot be reached duo to the formation of tar and char. CR increased with the increase of temperature and oxidation coefficient

  1. A Data-Driven Response Virtual Sensor Technique with Partial Vibration Measurements Using Convolutional Neural Network

    Science.gov (United States)

    Sun, Shan-Bin; He, Yuan-Yuan; Zhou, Si-Da; Yue, Zhen-Jiang

    2017-01-01

    Measurement of dynamic responses plays an important role in structural health monitoring, damage detection and other fields of research. However, in aerospace engineering, the physical sensors are limited in the operational conditions of spacecraft, due to the severe environment in outer space. This paper proposes a virtual sensor model with partial vibration measurements using a convolutional neural network. The transmissibility function is employed as prior knowledge. A four-layer neural network with two convolutional layers, one fully connected layer, and an output layer is proposed as the predicting model. Numerical examples of two different structural dynamic systems demonstrate the performance of the proposed approach. The excellence of the novel technique is further indicated using a simply supported beam experiment comparing to a modal-model-based virtual sensor, which uses modal parameters, such as mode shapes, for estimating the responses of the faulty sensors. The results show that the presented data-driven response virtual sensor technique can predict structural response with high accuracy. PMID:29231868

  2. A Data-Driven Response Virtual Sensor Technique with Partial Vibration Measurements Using Convolutional Neural Network.

    Science.gov (United States)

    Sun, Shan-Bin; He, Yuan-Yuan; Zhou, Si-Da; Yue, Zhen-Jiang

    2017-12-12

    Measurement of dynamic responses plays an important role in structural health monitoring, damage detection and other fields of research. However, in aerospace engineering, the physical sensors are limited in the operational conditions of spacecraft, due to the severe environment in outer space. This paper proposes a virtual sensor model with partial vibration measurements using a convolutional neural network. The transmissibility function is employed as prior knowledge. A four-layer neural network with two convolutional layers, one fully connected layer, and an output layer is proposed as the predicting model. Numerical examples of two different structural dynamic systems demonstrate the performance of the proposed approach. The excellence of the novel technique is further indicated using a simply supported beam experiment comparing to a modal-model-based virtual sensor, which uses modal parameters, such as mode shapes, for estimating the responses of the faulty sensors. The results show that the presented data-driven response virtual sensor technique can predict structural response with high accuracy.

  3. Proposal of early retreatment with iloprost in partially responsive patients with bone marrow edema syndrome: a case report

    Directory of Open Access Journals (Sweden)

    Simone Meini

    2012-12-01

    Full Text Available Background Avascular Necrosis (AVN is defined as the cellular death of bone components due to an alteration of the blood supply, resulting in Edema of the Bone Marrow (BME, structural collapse and bone destruction. In advanced stages, AVN requires surgery. One emerging medical treatment for supporting osseous perfusion is the administration of iloprost.Materials and methods A 38-year-old woman presented with severe BME of the left hip (primary, persisting for 6 weeks. She was treated with iloprost iv at 2 ng/kg/min for 6 hours/day for 5 days, and after 4 weeks, the treatment was repeated at 1.5 ng/kg/min for 6 hours for 5 days because she exhibited only a partial response to the first treatment. Complete remission was obtained, documented clinically and on Magnetic Resonance Imaging (MRI. Her Harris Hip Score (HHS increased from 29.90 to 97. No significant adverse events related to iloprost were registered. No surgical procedures were necessary.Conclusions In most cases, iloprost is administered in a single cycle of treatment over 5 days at 1-2 ng/kg/min for 6 hours/day, but no research has investigated the effectiveness of early retreatment after the first cycle results in only a partially response. Only a few studies examining small numbers of patients have evaluated iloprost in AVN/BME, preferring, in most cases, the dose of 1 ng/kg/min and obtaining clinical improvement both in BME and in AVN in times comparable to surgical core decompression. This case report demonstrates the safety and effectiveness of early repetition of the maximal dose of iloprost before BME evolves into AVN, as well as in cases initially appearing serious and requiring surgical procedures.

  4. Low Complexity Encoder of High Rate Irregular QC-LDPC Codes for Partial Response Channels

    Directory of Open Access Journals (Sweden)

    IMTAWIL, V.

    2011-11-01

    Full Text Available High rate irregular QC-LDPC codes based on circulant permutation matrices, for efficient encoder implementation, are proposed in this article. The structure of the code is an approximate lower triangular matrix. In addition, we present two novel efficient encoding techniques for generating redundant bits. The complexity of the encoder implementation depends on the number of parity bits of the code for the one-stage encoding and the length of the code for the two-stage encoding. The advantage of both encoding techniques is that few XOR-gates are used in the encoder implementation. Simulation results on partial response channels also show that the BER performance of the proposed code has gain over other QC-LDPC codes.

  5. Compensatory Paracrine Mechanisms That Define The Urothelial Response to Injury in Partial Bladder Outlet Obstruction

    Energy Technology Data Exchange (ETDEWEB)

    Bassuk, James; Lendvay, Thomas S.; Sweet, Robert; Han, Chang-Hee; Soygur, Tarkan; Cheng, Jan-Fang; Plaire, J. Chadwick; Charleston, Jay S.; Charleston, Lynne B.; Bagai, Shelly; Cochrane, Kimberly; Rubio, Eric; Bassuk, James A.; Fuchs, Elaine

    2007-06-21

    Diseases and conditions affecting the lower urinary tract are a leading cause of dysfunctional sexual health, incontinence, infection, and kidney failure. The growth, differentiation, and repair of the bladder's epithelial lining are regulated, in part, by fibroblast growth factor (FGF)-7 and -10 via a paracrine cascade originating in the mesenchyme (lamina propria) and targeting the receptor for FGF-7 and -10 within the transitional epithelium (urothelium). The FGF-7 gene is located at the 15q15-q21.1 locus on chromosome 15 and four exons generate a 3.852-kb mRNA. Five duplicated FGF-7 gene sequences that localized to chromosome 9 were predicted not to generate functional protein products, thus validating the use of FGF-7-null mice as an experimental model. Recombinant FGF-7 and -10 induced proliferation of human urothelial cells in vitro and transitional epithelium of wild-type and FGF-7-null mice in vivo.To determine the extent that induction of urothelial cell proliferation during the bladder response to injury is dependent on FGF-7, an animal model of partial bladder outlet obstruction was developed. Unbiased stereology was used to measure the percentage of proliferating urothelial cells between obstructed groups of wild-type and FGF-7-null mice. The stereological analysis indicated that a statistical significant difference did not exist between the two groups, suggesting that FGF-7 is not essential for urothelial cell proliferation in response to partial outlet obstruction. In contrast, a significant increase in FGF-10 expression was observed in the obstructed FGF-7-null group, indicating that the compensatory pathway that functions in this model results in urothelial repair.

  6. Esophageal mucosal breaks in gastroesophageal reflux disease partially responsive to proton pump inhibitor therapy.

    Science.gov (United States)

    Shaheen, Nicholas J; Denison, Hans; Björck, Karin; Silberg, Debra G

    2013-04-01

    Approximately 20-30% of patients with gastroesophageal reflux disease (GERD) do not experience complete symptom resolution during proton pump inhibitor (PPI) therapy. The aim of this study was to determine the prevalence of esophageal mucosal breaks among patients who have a partial response to PPI therapy. This was an analysis of data from a phase 2b clinical trial carried out to assess the efficacy and safety of a reflux inhibitor, lesogaberan (AZD3355), as an add-on to PPI therapy in this patient population (clinicaltrials.gov reference: NCT01005251). A total of 661 patients with persistent GERD symptoms who had received a minimum of 4 weeks of PPI therapy were included in the study. The prevalence of esophageal mucosal breaks was assessed according to (i) the most recent endoscopy results from within the previous 24 months, if available ("historical" endoscopies), and (ii) the results of endoscopies performed at study baseline ("baseline" endoscopies). Baseline endoscopies were not carried out in patients who had a historical endoscopy showing an absence of esophageal mucosal breaks. Historical endoscopy results were available for 244 patients, of whom 48 (19.7%) had esophageal mucosal breaks. Baseline endoscopies were carried out in 465 patients, of whom 146 (31.4%) had esophageal mucosal breaks. Sensitivity analyses showed a prevalence of esophageal mucosal breaks of 20-30%. In both the historical and baseline endoscopies, most esophageal mucosal breaks were Los Angeles grades A or B. In patients with GERD symptoms partially responsive to PPI therapy, mild-to-moderate severity esophageal mucosal breaks are common (prevalence 20-30%), and may contribute to symptom etiology.

  7. Partial oxidation of landfill leachate in supercritical water: Optimization by response surface methodology

    Energy Technology Data Exchange (ETDEWEB)

    Gong, Yanmeng; Wang, Shuzhong; Xu, Haidong; Guo, Yang; Tang, Xingying

    2015-09-15

    Highlights: • Partial oxidation of landfill leachate in supercritical water was investigated. • The process was optimized by Box–Behnken design and response surface methodology. • GY{sub H2}, TRE and CR could exhibit up to 14.32 mmol·gTOC{sup −1}, 82.54% and 94.56%. • Small amounts of oxidant can decrease the generation of tar and char. - Abstract: To achieve the maximum H{sub 2} yield (GY{sub H2}), TOC removal rate (TRE) and carbon recovery rate (CR), response surface methodology was applied to optimize the process parameters for supercritical water partial oxidation (SWPO) of landfill leachate in a batch reactor. Quadratic polynomial models for GY{sub H2}, CR and TRE were established with Box–Behnken design. GY{sub H2}, CR and TRE reached up to 14.32 mmol·gTOC{sup −1}, 82.54% and 94.56% under optimum conditions, respectively. TRE was invariably above 91.87%. In contrast, TC removal rate (TR) only changed from 8.76% to 32.98%. Furthermore, carbonate and bicarbonate were the most abundant carbonaceous substances in product, whereas CO{sub 2} and H{sub 2} were the most abundant gaseous products. As a product of nitrogen-containing organics, NH{sub 3} has an important effect on gas composition. The carbon balance cannot be reached duo to the formation of tar and char. CR increased with the increase of temperature and oxidation coefficient.

  8. The Dif Identification in Constructed Response Items Using Partial Credit Model

    Directory of Open Access Journals (Sweden)

    Heri Retnawati

    2017-10-01

    Full Text Available The study was to identify the load, the type and the significance of differential item functioning (DIF in constructed response item using the partial credit model (PCM. The data in the study were the students’ instruments and the students’ responses toward the PISA-like test items that had been completed by 386 ninth grade students and 460 tenth grade students who had been about 15 years old in the Province of Yogyakarta Special Region in Indonesia. The analysis toward the item characteristics through the student categorization based on their class was conducted toward the PCM using CONQUEST software. Furthermore, by applying these items characteristics, the researcher draw the category response function (CRF graphic in order to identify whether the type of DIF content had been in uniform or non-uniform. The significance of DIF was identified by comparing the discrepancy between the difficulty level parameter and the error in the CONQUEST output results. The results of the analysis showed that from 18 items that had been analyzed there were 4 items which had not been identified load DIF, there were 5 items that had been identified containing DIF but not statistically significant and there were 9 items that had been identified containing DIF significantly. The causes of items containing DIF were discussed.

  9. In response to partial plant shading, the lack of phytochrome A does not directly induce leaf senescence but alters the fine-tuning of chlorophyll biosynthesis

    Science.gov (United States)

    Brouwer, Bastiaan; Gardeström, Per; Keech, Olivier

    2014-01-01

    Phytochrome is thought to control the induction of leaf senescence directly, however, the signalling and molecular mechanisms remain unclear. In the present study, an ecophysiological approach was used to establish a functional connection between phytochrome signalling and the physiological processes underlying the induction of leaf senescence in response to shade. With shade it is important to distinguish between complete and partial shading, during which either the whole or only a part of the plant is shaded, respectively. It is first shown here that, while PHYB is required to maintain chlorophyll content in a completely shaded plant, only PHYA is involved in maintaining the leaf chlorophyll content in response to partial plant shading. Second, it is shown that leaf yellowing associated with strong partial shading in phyA-mutant plants actually correlates to a decreased biosynthesis of chlorophyll rather than to an increase of its degradation. Third, it is shown that the physiological impact of this decreased biosynthesis of chlorophyll in strongly shaded phyA-mutant leaves is accompanied by a decreased capacity to adjust the Light Compensation Point. However, the increased leaf yellowing in phyA-mutant plants is not accompanied by an increase of senescence-specific molecular markers, which argues against a direct role of PHYA in inducing leaf senescence in response to partial shade. In conclusion, it is proposed that PHYA, but not PHYB, is essential for fine-tuning the chlorophyll biosynthetic pathway in response to partial shading. In turn, this mechanism allows the shaded leaf to adjust its photosynthetic machinery to very low irradiances, thus maintaining a positive carbon balance and repressing the induction of leaf senescence, which can occur under prolonged periods of shade. PMID:24604733

  10. Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1, Dose-Escalation Protocol With Radiation Response Biomarkers

    International Nuclear Information System (INIS)

    Horton, Janet K.; Blitzblau, Rachel C.; Yoo, Sua; Geradts, Joseph; Chang, Zheng; Baker, Jay A.; Georgiade, Gregory S.; Chen, Wei; Siamakpour-Reihani, Sharareh; Wang, Chunhao; Broadwater, Gloria; Groth, Jeff; Palta, Manisha; Dewhirst, Mark; Barry, William T.; Duffy, Eileen A.

    2015-01-01

    Purpose: Women with biologically favorable early-stage breast cancer are increasingly treated with accelerated partial breast radiation (PBI). However, treatment-related morbidities have been linked to the large postoperative treatment volumes required for external beam PBI. Relative to external beam delivery, alternative PBI techniques require equipment that is not universally available. To address these issues, we designed a phase 1 trial utilizing widely available technology to 1) evaluate the safety of a single radiation treatment delivered preoperatively to the small-volume, intact breast tumor and 2) identify imaging and genomic markers of radiation response. Methods and Materials: Women aged ≥55 years with clinically node-negative, estrogen receptor–positive, and/or progesterone receptor–positive HER2−, T1 invasive carcinomas, or low- to intermediate-grade in situ disease ≤2 cm were enrolled (n=32). Intensity modulated radiation therapy was used to deliver 15 Gy (n=8), 18 Gy (n=8), or 21 Gy (n=16) to the tumor with a 1.5-cm margin. Lumpectomy was performed within 10 days. Paired pre- and postradiation magnetic resonance images and patient tumor samples were analyzed. Results: No dose-limiting toxicity was observed. At a median follow-up of 23 months, there have been no recurrences. Physician-rated cosmetic outcomes were good/excellent, and chronic toxicities were grade 1 to 2 (fibrosis, hyperpigmentation) in patients receiving preoperative radiation only. Evidence of dose-dependent changes in vascular permeability, cell density, and expression of genes regulating immunity and cell death were seen in response to radiation. Conclusions: Preoperative single-dose radiation therapy to intact breast tumors is well tolerated. Radiation response is marked by early indicators of cell death in this biologically favorable patient cohort. This study represents a first step toward a novel partial breast radiation approach. Preoperative radiation should

  11. Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1, Dose-Escalation Protocol With Radiation Response Biomarkers

    Energy Technology Data Exchange (ETDEWEB)

    Horton, Janet K., E-mail: janet.horton@duke.edu [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Blitzblau, Rachel C.; Yoo, Sua [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Geradts, Joseph [Department of Pathology, Duke University Medical Center, Durham, North Carolina (United States); Chang, Zheng [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Baker, Jay A. [Department of Radiology, Duke University Medical Center, Durham, North Carolina (United States); Georgiade, Gregory S. [Department of Surgery, Duke University Medical Center, Durham, North Carolina (United States); Chen, Wei [Department of Bioinformatics: Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina (United States); Siamakpour-Reihani, Sharareh; Wang, Chunhao [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Broadwater, Gloria [Department of Biostatistics: Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina (United States); Groth, Jeff [Department of Pathology, Duke University Medical Center, Durham, North Carolina (United States); Palta, Manisha; Dewhirst, Mark [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); Barry, William T. [Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina (United States); Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts (United States); Duffy, Eileen A. [Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina (United States); and others

    2015-07-15

    Purpose: Women with biologically favorable early-stage breast cancer are increasingly treated with accelerated partial breast radiation (PBI). However, treatment-related morbidities have been linked to the large postoperative treatment volumes required for external beam PBI. Relative to external beam delivery, alternative PBI techniques require equipment that is not universally available. To address these issues, we designed a phase 1 trial utilizing widely available technology to 1) evaluate the safety of a single radiation treatment delivered preoperatively to the small-volume, intact breast tumor and 2) identify imaging and genomic markers of radiation response. Methods and Materials: Women aged ≥55 years with clinically node-negative, estrogen receptor–positive, and/or progesterone receptor–positive HER2−, T1 invasive carcinomas, or low- to intermediate-grade in situ disease ≤2 cm were enrolled (n=32). Intensity modulated radiation therapy was used to deliver 15 Gy (n=8), 18 Gy (n=8), or 21 Gy (n=16) to the tumor with a 1.5-cm margin. Lumpectomy was performed within 10 days. Paired pre- and postradiation magnetic resonance images and patient tumor samples were analyzed. Results: No dose-limiting toxicity was observed. At a median follow-up of 23 months, there have been no recurrences. Physician-rated cosmetic outcomes were good/excellent, and chronic toxicities were grade 1 to 2 (fibrosis, hyperpigmentation) in patients receiving preoperative radiation only. Evidence of dose-dependent changes in vascular permeability, cell density, and expression of genes regulating immunity and cell death were seen in response to radiation. Conclusions: Preoperative single-dose radiation therapy to intact breast tumors is well tolerated. Radiation response is marked by early indicators of cell death in this biologically favorable patient cohort. This study represents a first step toward a novel partial breast radiation approach. Preoperative radiation should

  12. Energy regulation in China: Objective selection, potential assessment and responsibility sharing by partial frontier analysis

    International Nuclear Information System (INIS)

    Xia, X.H.; Chen, Y.B.; Li, J.S.; Tasawar, H.; Alsaedi, A.; Chen, G.Q.

    2014-01-01

    To cope with the excessive growth of energy consumption, the Chinese government has been trying to strengthen the energy regulation system by introducing new initiatives that aim at controlling the total amount of energy consumption. A partial frontier analysis is performed in this paper to make a comparative assessment of the combinations of possible energy conservation objectives, new constraints and regulation strategies. According to the characteristics of the coordination of existing regulation structure and the optimality of regulation strategy, four scenarios are constructed and regional responsibilities are reasonably divided by fully considering the production technology in the economy. The relative importance of output objectives and the total amount controlling is compared and the impacts on the regional economy caused by the changes of regulation strategy are also evaluated for updating regulation policy. - Highlights: • New initiatives to control the total amount of energy consumption are evaluated. • Twenty-four regulation strategies and four scenarios are designed and compared. • Crucial regions for each sector and regional potential are identified. • The national goals of energy abatement are decomposed into regional responsibilities. • The changes of regulation strategy are evaluated for updating regulation policy

  13. Glycaemic, uricaemic and blood pressure response to beverages with partial fructose replacement of sucrose.

    Science.gov (United States)

    Rodrigues, Natasha; Peng, Mei; Oey, Indrawati; Venn, Bernard Joseph

    2018-03-20

    The European Food Safety Authority approved a health claim (ID558) relating to lowered postprandial glycaemia when fructose replaces 30% of sucrose in foods and beverages. We assessed the effects of partial replacement of sucrose with fructose on serum glucose, uric acid and blood pressure. A randomised, crossover, double blind trial of 12 normoglycaemic participants consuming beverages containing 50 g blends of fructose and sucrose in proportions; 67% sucrose/33% fructose (67%S:33%F); 50% each (50%S:50%F) and 33%S:67%F; a 100% sucrose reference beverage was tested twice. Serum glucose and uric acid concentrations were measured at 0, 15, 30, 45, 60, 90 and 120 min and incremental area-under-the-curve (iAUC) calculated. The geometric mean (95% CI) glycaemic iAUC following the 100% sucrose, 67%S:33%F, 50%S:50%F and 33%S:67%F blended beverages were 96 (63,145), 71 (46,109), 60 (39, 93) and 39 (12, 86) mmol/L min, respectively. At 33% fructose replacement, the proportionally lower iAUC of -28.5% (95% CI: -62.1, 5.2) mmol/L min was not different to sucrose alone. The response was lowered by fructose replacement of 50 and 67% and overall there was an inverse association (p beverages were 1320 (393, 2248), 3062 (1553, 4570), 3646 (2446, 4847), 3623 (2020, 5226) µmol/L min. Uric acid concentration was raised by all fructose-containing beverages with 33% fructose replacement causing an increase of 1741 (95% CI: 655, 2829) µmol/L min compared with sucrose alone. Blood pressure was not different among beverages. Reduced postprandial glycaemia was achieved by the substitution of sucrose with fructose although elevated uricaemic responses should be cautioned.

  14. How partial reinforcement of food cues affects the extinction and reacquisition of appetitive responses. A new model for dieting success?

    Science.gov (United States)

    van den Akker, Karolien; Havermans, Remco C; Bouton, Mark E; Jansen, Anita

    2014-10-01

    Animals and humans can easily learn to associate an initially neutral cue with food intake through classical conditioning, but extinction of learned appetitive responses can be more difficult. Intermittent or partial reinforcement of food cues causes especially persistent behaviour in animals: after exposure to such learning schedules, the decline in responding that occurs during extinction is slow. After extinction, increases in responding with renewed reinforcement of food cues (reacquisition) might be less rapid after acquisition with partial reinforcement. In humans, it may be that the eating behaviour of some individuals resembles partial reinforcement schedules to a greater extent, possibly affecting dieting success by interacting with extinction and reacquisition. Furthermore, impulsivity has been associated with less successful dieting, and this association might be explained by impulsivity affecting the learning and extinction of appetitive responses. In the present two studies, the effects of different reinforcement schedules and impulsivity on the acquisition, extinction, and reacquisition of appetitive responses were investigated in a conditioning paradigm involving food rewards in healthy humans. Overall, the results indicate both partial reinforcement schedules and, possibly, impulsivity to be associated with worse extinction performance. A new model of dieting success is proposed: learning histories and, perhaps, certain personality traits (impulsivity) can interfere with the extinction and reacquisition of appetitive responses to food cues and they may be causally related to unsuccessful dieting. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. A Study of Reverse-Worded Matched Item Pairs Using the Generalized Partial Credit and Nominal Response Models

    Science.gov (United States)

    Matlock Cole, Ki Lynn; Turner, Ronna C.; Gitchel, W. Dent

    2018-01-01

    The generalized partial credit model (GPCM) is often used for polytomous data; however, the nominal response model (NRM) allows for the investigation of how adjacent categories may discriminate differently when items are positively or negatively worded. Ten items from three different self-reported scales were used (anxiety, depression, and…

  16. Partial response to biotin therapy in a patient with holocarboxylase synthetase deficiency: clinical, biochemical, and molecular genetic aspects

    NARCIS (Netherlands)

    Santer, R.; Muhle, H.; Suormala, T.; Baumgartner, E. R.; Duran, M.; Yang, X.; Aoki, Y.; Suzuki, Y.; Stephani, U.

    2003-01-01

    We report the clinical course and biochemical findings of a 10-year-old, mentally retarded girl with late-onset holocarboxylase synthetase (HCS, gene symbol HLCS) deficiency and only partial response to biotin. On treatment, even with an unusually high dose of 200mg/day, activities of the

  17. CONCLUSIONS Urban Children and Adolescents

    Indian Academy of Sciences (India)

    CONCLUSIONS Urban Children and Adolescents. Increasing prevalence of overweight and obesity and measures of regional (central) adiposity. High prevalence of markers of dysmetabolic state in urban adolescents. ~10% prevalence of dysglycemia in overweight / obese school children.

  18. Chapter 6: Conclusions and recommendations

    International Nuclear Information System (INIS)

    1995-01-01

    This chapter provides a brief summary of conclusions with respect to project implementation issues. Furthermore, the chapter contains recommendations on future applications of the modelling system and on water resources management in the project area

  19. Summary and conclusions [Chapter 11

    Science.gov (United States)

    Daniel G. Neary; John N. Rinne; Alvin L.. Medina

    2012-01-01

    Summaries and conclusions of each chapter are compiled here to provide a “Quick Reference” guide of major results and recommendations for the UVR. More detail can be obtained from individual chapters.

  20. Different Training Loads Partially Influence Physiological Responses to the Preparation Period in Basketball.

    Science.gov (United States)

    Ferioli, Davide; Bosio, Andrea; La Torre, Antonio; Carlomagno, Domenico; Connolly, Darragh R; Rampinini, Ermanno

    2018-03-01

    Ferioli, D, Bosio, A, La Torre, A, Carlomagno, D, Connolly, DR, and Rampinini, E. Different training loads partially influence physiological responses to preparation period in basketball. J Strength Cond Res 32(3): 790-797, 2018-The aim of this study was to compare the session rating of perceived exertion training load (sRPE-TL), training volume (TV), and the changes in physical fitness between professional (n = 14) and semiprofessional (n = 18) basketball players during the preparation period. Furthermore, relationships between sRPE-TL and TV with changes in physical fitness level were investigated. The players performed the Yo-Yo intermittent recovery test-level 1 (Yo-Yo IR1) before and after the preparation period. In addition, physiological responses to a standardized 6-minute continuous running test (Mognoni's test) and to a standardized 5-minute high-intensity intermittent running test (HIT) were measured. Session rating of perceived exertion-TL and TV were greater for professional (5,241 ± 1787 AU; 914 ± 122 minutes) compared with semiprofessional players (2,408 ± 487 AU; 583 ± 65 minutes). Despite these differences, Yo-Yo IR1 performance improvements (∼30%) and physiological adaptations to the Mognoni's test were similar between the 2 groups. Furthermore, physiological adaptations to HIT were slightly greater for professional compared with semiprofessional players; however, the magnitude of these effects was only small/moderate. No clear relationships were found between sRPE-TL and changes in Yo-Yo IR1 performance and Mognoni's test (rs ± 90% confidence interval [CI]: Yo-Yo IR1, 0.18 ± 0.30; Mognoni's test, -0.14 ± 0.29). Only moderate relationships were found between sRPE-TL and changes in HIT (rs ± 90% CI: [La], -0.48 ± 0.23; [H], -0.42 ± 0.25). These results raise doubts on the effectiveness of using high sRPE-TL and TV during the preparation period to improve the physical fitness level of players. The Yo-Yo IR1 seems to be sensitive to

  1. CONCLUSIONS New Delhi Birth Cohort

    Indian Academy of Sciences (India)

    CONCLUSIONS New Delhi Birth Cohort. Crossing BMI centiles and early adiposity rebound associated with adult metabolic syndrome. BMI gain in infancy and early childhood – associated more with adult lean mass. BMI gain in later childhood / adolescence – associated more with adult fat mass and constituents of ...

  2. Porn again: some final conclusions.

    Science.gov (United States)

    Ellis, Shannon R; Whitehead, Bruce W

    2004-01-01

    Contributors were asked to respond to seven questions examining various aspects of gay male pornography. Their responses were collated with the hope that the reader may gain additional insight into this topic.

  3. Human Biomechanical and Cardiopulmonary Responses to Partial Gravity – A Systematic Review

    Directory of Open Access Journals (Sweden)

    Charlotte Richter

    2017-08-01

    Full Text Available The European Space Agency has recently announced to progress from low Earth orbit missions on the International Space Station to other mission scenarios such as exploration of the Moon or Mars. Therefore, the Moon is considered to be the next likely target for European human space explorations. Compared to microgravity (μg, only very little is known about the physiological effects of exposure to partial gravity (μg < partial gravity <1 g. However, previous research studies and experiences made during the Apollo missions comprise a valuable source of information that should be taken into account when planning human space explorations to reduced gravity environments. This systematic review summarizes the different effects of partial gravity (0.1–0.4 g on the human musculoskeletal, cardiovascular and respiratory systems using data collected during the Apollo missions as well as outcomes from terrestrial models of reduced gravity with either 1 g or microgravity as a control. The evidence-based findings seek to facilitate decision making concerning the best medical and exercise support to maintain astronauts' health during future missions in partial gravity. The initial search generated 1,323 publication hits. Out of these 1,323 publications, 43 studies were included into the present analysis and relevant data were extracted. None of the 43 included studies investigated long-term effects. Studies investigating the immediate effects of partial gravity exposure reveal that cardiopulmonary parameters such as heart rate, oxygen consumption, metabolic rate, and cost of transport are reduced compared to 1 g, whereas stroke volume seems to increase with decreasing gravity levels. Biomechanical studies reveal that ground reaction forces, mechanical work, stance phase duration, stride frequency, duty factor and preferred walk-to-run transition speed are reduced compared to 1 g. Partial gravity exposure below 0.4 g seems to be insufficient to maintain

  4. Intra-ligamentary autologous conditioned plasma and healing response to treat partial ACL ruptures.

    Science.gov (United States)

    Koch, Matthias; Matteo, Berardo Di; Eichhorn, Jürgen; Zellner, Johannes; Mayr, Felix; Krutsch, Werner; Achenbach, Leonard; Woehl, Rebecca; Nerlich, Michael; Angele, Peter

    2018-05-01

    Conservative treatment of partial ACL ruptures is associated with a high failure rate, and often patients undergo ACL reconstruction. ACL preservation by trephination of the ACL origin and application of Autologous Conditioned Plasma (ACP) seems to be an intriguing new treatment option to favour ACL tissue healing and avoid traditional reconstruction. The aim of this study was to describe the mid-term outcomes of this new ACL preserving technique. Twenty-four patients (mean age 41.8 years) affected by partial rupture of one or both ACL bundles were included in the present trial. The partial ACL tears were arthroscopically assessed and classified according to a new five step grading system. All patients were treated by trephination of the femoral ACL stump and intra-ligamentary application of ACP. The postoperative outcome was evaluated by both subjective scores and stability testing up to a mean of 25.1 months' follow-up. Adverse events and failure rate were also documented. Clinical outcome was good to excellent with IKDC subjective 82.7 (SD 11.8), Lysholm 87.6 (SD 8.1), Tegner 5.3 (SD 2.1), Cincinnati 88.7 (SD 14.8). The failure rate (i.e. persisting knee instability assessed clinically or by rolimeter) was 12.5%. At objective measurements, knee joints showed a firm endpoint in Lachman test, negative pivot shift phenomenon and a significant reduction in AP-laxity compared to pre-operative status by rolimeter testing (p = 0.002). Return to sport practice was achieved after mean 4.8 months (SD 4.1). ACL stump trephination and concomitant intra-ligamentary application of ACP revealed promising results at mid-term follow-up to treat partial ACL lesions.

  5. Screening of ionic cores in partially ionized plasmas within linear response

    International Nuclear Information System (INIS)

    Gericke, D. O.; Vorberger, J.; Wuensch, K.; Gregori, G.

    2010-01-01

    We employ a pseudopotential approach to investigate the screening of ionic cores in partially ionized plasmas. Here, the effect of the tightly bound electrons is condensed into an effective potential between the (free) valence electrons and the ionic cores. Even for weak electron-ion coupling, the corresponding screening clouds show strong modifications from the Debye result for elements heavier than helium. Modifications of the theoretically predicted x-ray scattering signal and implications on measurements are discussed.

  6. REGULATION OF IMMUNE RESPONSE OF PATIENTS WITH PARTIALLY CONTROLLED vs CONTROLLED BRONCHIAL ASTHMA

    Directory of Open Access Journals (Sweden)

    E. Yu. Barabash

    2017-01-01

    Full Text Available A control group included seventeen conditionally healthy people (Group 1. Eighty-eight patients with proven bronchial asthma (BA at the age of 22 to 48 were enrolled into the study. I.e., Group 2 included nine patients with well-controlled BA. Group 3 included persons with partially controlled BA (n=79. There were 8 people with easily treated BA in group 2, and 57 such cases in Group 3. The levels of interleukins (IL-4, IL-10, IL-17A, interferon-γ (IFNγ, and tumor-α necrosis factor (TNFα were monitored by means of flow cytometry technique. The parameters of cellular immunity were registered by flow cytofluorimetry assays. Phagocytosis indicators were studied by means of D. Mayansky method, metabolic activity of neutrophils, by the B.Park method, as modified by E.Shmelev. Evaluation of cellular immunity did not reveal statistically significant differences for distinct CD subpopulations between healthy controls and BA patients. The patients with controlled and partially controlled BA exhibited some changes in cytokine concentrations, i.e., increased IL-4, IL-17А, IL-10 and TNFα levels; changes in phagocytosis and oxygen dependent bactericidal activities of neutrophils. We have revealed higher concentrations of IL-4, IL-17А in the less controlled BA (group 3 , as compared with group 2. TNFα induction remained at significantly higher level in both groups of BA patients, exceeding mean control values by 2.3 times. The degree of IL-10 production in group 2 with controlled BA was significantly higher than in group with partial disease control (group 3, p < 0.001, thus suggesting application of IL-10 levels as an index of active inflammation control. Patients with BA (groups 2, 3 exhibited a decrease of basal IFNγ, as compared to healthy people (p < 0.001. In group 3 (partial control, this parameter was 3-fold lower than in healthy persons. Evaluation of monocyte/phagocyte functions showed statistically significant differences between BA

  7. Growth hormone and prolactin responses during partial and whole body warm-water immersions.

    Science.gov (United States)

    Koska, J; Rovensky, J; Zimanova, T; Vigas, M

    2003-05-01

    To elucidate the role of core and skin thermoreceptors in the release of growth hormone (GH) and prolactin (PRL), a sequence of two experiments using whole-body (head-out) and partial (one forearm) hot water immersions was performed. Experiment 1: Nine healthy men were exposed to head-out and partial water immersions (25 min, 38-39 degrees C). Head-out immersion increased the core temperature (38.0 +/- 0.1 vs. 36.7 +/- 0.1 degrees C, P immersion the core temperature was slightly elevated (36.8 +/- 0.1 vs. 36.6 +/- 0.1, P immersed one forearm once in 39 degrees C and once in 38 degrees C water. The measurements were performed in 5-min intervals. The GH concentration increased gradually from the beginning of the immersions (min 10; 39 degrees C: 1.9 +/- 1.0 vs. 0.6 +/- 0.3 ng mL(-1), P Immersion in 38 degrees C water did not induce core temperature changes. Peripheral thermoreceptors are involved in GH release when the body is exposed to elevated environmental temperature while a substantial elevation of core temperature is a precondition of PRL release.

  8. Marginal ridge fracture resistance, microleakage and pulpal response to glass ionomer/glass cermet partial tunnel restorations.

    Science.gov (United States)

    Prabhu, N T; Munshi, A K; Shetty, T R

    1997-01-01

    Sixty sound premolars which were to be extracted for orthodontic treatment purposes were restored either with glass ionomer cement or glass cermet cements after partial tunnel preparation, and prior to the extraction after a time interval of 30 and 60 days respectively. The teeth were then subjected to marginal ridge fracture resistance, microleakage study using dye penetration and histological evaluation of the pulpal response to these materials. Both the materials exhibited increase in marginal ridge fracture resistance at 60 days, with minimal degree of microleakage and were biologically compatible with the dental pulp.

  9. Dose-response relationships for chromosome aberrations in peripheral blood lymphocytes after whole- and partial-body irradiations. Pt. 1

    International Nuclear Information System (INIS)

    Liniecki, J.; Bajerska, A.; Wyszynska, K.

    1983-01-01

    Dose-response relationships were established for yield of dicentrics and for a fraction of damaged metaphases in lymphocytes after γ-irradiation of rabbits' whole blood in vitro. These relationships were based on the scoring of cells only in their first post-stimulation division and they served as a reference system for comparison with results of 60 Co γ-irradiation in vivo, either of the whole or of predetermined parts of an animal's body. There was a statistically acceptable agreement between dose-response data established for dicentric yield after whole-body irradiation in vivo and the reference dose-response curve derived from exposure of rabbit's blood in vitro. For partial-body (1/2) irradiations there was a satisfactory agreement between the dose-response curves in vitro for dicentric yield and fraction of metaphases damaged on the one hand and the response in vivo when the latter was related to mean doses to circulating blood. However, there was a drastic disagreement with the dose responses in vitro when measured cytogenetic quantities were plotted versus mean doses to body mass. When the latter were substituted for by comparable doses to circulating blood the in vivo-in vitro agreement was acceptable after irradiation. (orig.)

  10. Identifying cochlear implant channels with poor electrode-neuron interface: electrically-evoked auditory brainstem responses measured with the partial tripolar configuration

    Science.gov (United States)

    Bierer, Julie Arenberg; Faulkner, Kathleen F.; Tremblay, Kelly L.

    2011-01-01

    Objectives The goal of this study was to compare cochlear implant behavioral measures and electrically-evoked auditory brainstem responses (EABRs) obtained with a spatially focused electrode configuration. It has been shown previously that channels with high thresholds, when measured with the tripolar configuration, exhibit relatively broad psychophysical tuning curves (Bierer and Faulkner, 2010). The elevated threshold and degraded spatial/spectral selectivity of such channels are consistent with a poor electrode-neuron interface, such as suboptimal electrode placement or reduced nerve survival. However, the psychophysical methods required to obtain these data are time intensive and may not be practical during a clinical mapping procedure, especially for young children. Here we have extended the previous investigation to determine if a physiological approach could provide a similar assessment of channel functionality. We hypothesized that, in accordance with the perceptual measures, higher EABR thresholds would correlate with steeper EABR amplitude growth functions, reflecting a degraded electrode-neuron interface. Design Data were collected from six cochlear implant listeners implanted with the HiRes 90k cochlear implant (Advanced Bionics). Single-channel thresholds and most comfortable listening levels were obtained for stimuli that varied in presumed electrical field size by using the partial tripolar configuration, for which a fraction of current (σ) from a center active electrode returns through two neighboring electrodes and the remainder through a distant indifferent electrode. EABRs were obtained in each subject for the two channels having the highest and lowest tripolar (σ=1 or 0.9) behavioral threshold. Evoked potentials were measured with both the monopolar (σ=0) and a more focused partial tripolar (σ ≥ 0.50) configuration. Results Consistent with previous studies, EABR thresholds were highly and positively correlated with behavioral thresholds

  11. Community emergency response to nuclear power plant accidents: A selected and partially annotated bibliography

    International Nuclear Information System (INIS)

    Youngen, G.

    1988-10-01

    The role of responding to emergencies at nuclear power plants is often considered the responsibility of the personnel onsite. This is true for most, if not all, of the incidents that may happen during the course of the plant's operating lifetime. There is however, the possibility of a major accident occurring at anytime. Major nuclear accidents at Chernobyl and Three Mile Island have taught their respective countries and communities a significant lesson in local emergency preparedness and response. Through these accidents, the rest of the world can also learn a great deal about planning, preparing and responding to the emergencies unique to nuclear power. This bibliography contains books, journal articles, conference papers and government reports on emergency response to nuclear power plant accidents. It does not contain citations for ''onsite'' response or planning, nor does it cover the areas of radiation releases from transportation accidents. The compiler has attempted to bring together a sampling of the world's collective written experience on dealing with nuclear reactor accidents on the sate, local and community levels. Since the accidents at Three Mile Island and Chernobyl, that written experience has grown enormously

  12. Community emergency response to nuclear power plant accidents: A selected and partially annotated bibliography

    Energy Technology Data Exchange (ETDEWEB)

    Youngen, G.

    1988-10-01

    The role of responding to emergencies at nuclear power plants is often considered the responsibility of the personnel onsite. This is true for most, if not all, of the incidents that may happen during the course of the plant`s operating lifetime. There is however, the possibility of a major accident occurring at anytime. Major nuclear accidents at Chernobyl and Three Mile Island have taught their respective countries and communities a significant lesson in local emergency preparedness and response. Through these accidents, the rest of the world can also learn a great deal about planning, preparing and responding to the emergencies unique to nuclear power. This bibliography contains books, journal articles, conference papers and government reports on emergency response to nuclear power plant accidents. It does not contain citations for ``onsite`` response or planning, nor does it cover the areas of radiation releases from transportation accidents. The compiler has attempted to bring together a sampling of the world`s collective written experience on dealing with nuclear reactor accidents on the sate, local and community levels. Since the accidents at Three Mile Island and Chernobyl, that written experience has grown enormously.

  13. Canopy arthropod response to density and distribution of green trees retained after partial harvest.

    Science.gov (United States)

    Timothy D. Schowalter; Yanli Zhang; Robert A. Progar

    2005-01-01

    We measured canopy arthropod responses to six contrasting green-tree retention treatments at six locations (blocks) in western Oregon and Washington as part of the Demonstration of Ecosystem Management Options (DEMO) study. Treatments were 100% retention (uncut), 75% retention with three 1-ha harvested gaps, 40% dispersed retention, 40% aggregated retention with five 1...

  14. Effects of RO 15-1788 on a running response rewarded on continuous or partial reinforcement schedules.

    Science.gov (United States)

    Hawkins, M; Sinden, J; Martin, I; Gray, J A

    1988-01-01

    Two experiments were run in which rats were rewarded with food for running in a straight alley at one trial a day, followed by extinction of the running response. During acquisition of the response, reward was delivered either on a continuous reinforcement (CRF) or on a quasirandom 50% partial reinforcement (PRF) schedule. The groups given PRF were more resistant to extinction than those given CRF, the well-known partial reinforcement extinction effect. In Experiment 1 different groups of rats were injected during acquisition only with 1, 5 or 10 mg/kg of the benzodiazepine antagonist, RO 15-1788, or with placebo. In Experiment 2, 5 mg/kg RO 15-1788 or placebo were administered in a full cross-over design during acquisition, extinction or both. At the end of Experiment 2 only [3H]-flunitrazepam binding was measured in either the presence or absence of added gamma-aminobutyrate (GABA) in homogenates of hippocampi dissected from the animals that had received behavioural training. The drug affected running speeds during both acquisition and extinction in different ways depending upon the schedule of reinforcement (CRF or PRF) and also gave rise to enhanced GABA stimulation of [3H]-flunitrazepam binding. The results are discussed in relation to the hypothesis that the neurochemical pathways by which reinforcement schedules modify behaviour include a step influenced by benzodiazepine receptors.

  15. Effects of CO2 laser irradiation on the wettability and human skin fibroblast cell response of magnesia partially stabilised zirconia

    International Nuclear Information System (INIS)

    Hao, L.; Lawrence, J.

    2003-01-01

    Human skin fibroblast cells in vitro responses on the surface of a bioinert zirconia ceramic partially stabilised with magnesia partially stabilised zirconia (MgO-PSZ) bioinert ceramic before and after CO 2 laser treatment were investigated to find the interrelationship between the cell adhesion, wettability and laser parameters. Contact angle, θ, measurements of a set of test liquids were a clear indication that surface treatment of the MgO-PSZ with a CO 2 laser brought about a reduction in θ, indicating that the wettability of the MgO-PSZ had been enhanced. A relationship was found between the wettability and the microstructure of the MgO-PSZ surface and laser processing parameters. It was subsequently deduced that the factors active in causing the observed modification in the wettability of the MgO-PSZ were the increases in the surface O 2 content and the polar component of the surface energy, γ sv p , the latter resulting from surface melting and resolidification. Moreover, the investigation into the human skin fibroblast cell response revealed that the CO 2 laser treatment of the MgO-PSZ had resulted in a surface favourable for cell adhesion, as the extent of cell attachment and adhesion on the MgO-PSZ surface was enhanced depending on laser parameters. Such an improvement in cell adhesion, which could be greatly beneficial to developing enhanced bonding at the tissue and implant interface, was influenced by the surface properties of the modified MgO-PSZ, particular wettability

  16. The shark Chiloscyllium griseum can orient using turn responses before and after partial telencephalon ablation.

    Science.gov (United States)

    Fuss, Theodora; Bleckmann, Horst; Schluessel, Vera

    2014-01-01

    This study assessed spatial memory and orientation strategies in Chiloscyllium griseum. In the presence of visual landmarks, six sharks were trained in a fixed turn response. Group 1 started from two possible compartments approaching two goal locations, while group 2 started from and approached only one location, respectively. The learning criterion was reached within 9 ± 5.29 (group 1) and 8.3 ± 3.51 sessions (group 2). Transfer tests revealed that sharks had applied a direction strategy, possibly in combination with some form of place learning. Without visual cues, sharks relied solely on the former. To identify the underlying neural substrate(s), telencephalic were lesioned and performance compared before and after surgery. Ablation of the dorsal and medial pallia only had an effect on one shark (group 1), indicating that the acquisition and retention of previously gained knowledge were unaffected in the remaining four individuals. Nonetheless, the shark re-learned the task. In summary, C. griseum can utilize fixed turn responses to navigate to a goal; there is also some evidence for the use of external visual landmarks while orienting. Probably, strategies can be used alone or in combination. Neither the dorsal nor medial pallium seems to be responsible for the acquisition and processing of egocentric information.

  17. Complex conductivity response to silver nanoparticles in partially saturated sand columns

    Science.gov (United States)

    Abdel Aal, Gamal; Atekwana, Estella A.; Werkema, D. Dale

    2017-02-01

    The increase in the use of nanoscale materials in consumer products has resulted in a growing concern of their potential hazard to ecosystems and public health from their accidental or intentional introduction to the environment. Key environmental, health, and safety research needs include knowledge and methods for their detection, characterization, fate, and transport. Specifically, techniques available for the direct detection and quantification of their fate and transport in the environment are limited. Their small size, high surface area to volume ratio, interfacial, and electrical properties make metallic nanoparticles, such as silver nanoparticles, good targets for detection using electrical geophysical techniques. Here we measured the complex conductivity response to silver nanoparticles in sand columns under varying moisture conditions (0-30%), nanoparticle concentrations (0-10 mg/g), lithology (presence of clay), pore water salinity (0.0275 and 0.1000 S/m), and particle size (35, 90-210 and 1500-2500 nm). Based on the Cole-Cole relaxation models we obtained the chargeability and the time constant. We demonstrate that complex conductivity can detect silver nanoparticles in porous media with the response enhanced by higher concentrations of silver nanoparticles, moisture content, ionic strength, clay content and particle diameter. Quantification of the volumetric silver nanoparticles content in the porous media can also be obtained from complex conductivity parameters based on the strong power law relationships.

  18. Partial response to cinacalcet treatment in a patient with secondary hyperparathyroidism undergoing hemodialysis: a case report

    Directory of Open Access Journals (Sweden)

    Conzo Giovanni

    2012-12-01

    Full Text Available Abstract Introduction In the treatment of secondary hyperparathyroidism of chronic kidney disease, calcimimetics - allosteric modulators of the calcium-sensing receptor - inhibit glandular hyperplasia and significantly reduce circulating parathyroid hormone levels. They have a major impact on the management of secondary hyperparathyroidism. Case presentation We present the clinical case of a 41-year-old Caucasian man undergoing chronic hemodialysis, who had a parathyroidectomy to treat severe secondary hyperparathyroidism resistant to cinacalcet treatment. Preoperatively, 24 months after high-dose cinacalcet hydrochloride, we observed a persistently elevated intact parathyroid hormone serum level, and detected clear parathyroid gland hyperplasia regression on ultrasound. We performed a three-gland parathyroidectomy, which was assumed to be total, associated with a hemithyroidectomy. Our patient then entered a hypoparathyroid state. A histopathological examination showed that the removed parathyroid glands were of small size, with a total weight of 1g, associated with a multifocal small papillary thyroid cancer. Conclusion In the management of secondary hyperparathyroidism, cinacalcet hydrochloride effectively reduces total parathyroid gland hyperplasia. However, a persisting elevated intact parathyroid hormone serum level may be observed, demonstrating that reduced parathyroid hyperplastic tissue may still be associated with severe secondary hyperparathyroidism. Even if calcimimetics are very effective in secondary hyperparathyroidism treatment, further studies are necessary for a better understanding of their actions.

  19. Power and Democracy in Denmark. Conclusions

    DEFF Research Database (Denmark)

    Andersen, Jørgen Goul; Christiansen, Peter Munk; Beck Jørgensen, Torben

    In 1997, the Danish Parliament decided to launch a power study, officially An Analysis of Democracy and Power in Denmark. A steering committee consisting of five independent researchers was assigned responsibility for the project. The Steering Committee has gathered the overall conclusions from...... the numerous projects under the Power Study, and this book is a short presentation of these conclusions.The main focus of the book is the state of democracy in Denmark at the dawn of the 21st century. How has democracy fared, has the development made things better or worse, and to which extent does......, and the political institutions show considerable democratic robustness. However, not everything has gone or is going well. There are still pronounced social divisions in Danish society, although their nature has changed somewhat. The ideal of an informed public debate does not always enjoy the best conditions...

  20. Memory retrieval in response to partial cues requires NMDA receptor-dependent neurotransmission in the medial prefrontal cortex.

    Science.gov (United States)

    Jo, Yong Sang; Choi, June-Seek

    2014-03-01

    The medial prefrontal cortex (mPFC) has been suggested to play a crucial role in retrieving detailed contextual information about a previous learning episode in response to a single retrieval cue. However, few studies investigated the neurochemical mechanisms that mediate the prefrontal retrieval process. In the current study, we examined whether N-methyl-D-aspartate receptors (NMDARs) in the mPFC were necessary for retrieval of a well-learned spatial location on the basis of partial or degraded spatial cues. Rats were initially trained to find a hidden platform in the Morris water maze using four extramaze cues in the surrounding environment. Their retrieval performance was subsequently tested under different cue conditions. Infusions of DL-2-amino-5-phosphonovaleric acid (APV), a NMDAR antagonist, significantly disrupted memory retrieval when three of the original cues were removed. By contrast, APV injections into the mPFC did not affect animals' retrieval performance when the original cues were presented or when three novels landmarks were added alongside the original cues. These results indicate that prefrontal NMDARs are required for memory retrieval when allocentric spatial information is degraded. NMDAR-dependent neurotransmission in the mPFC may facilitate an active retrieval process to reactivate complete contextual representations associated with partial retrieval cues. Copyright © 2013 Elsevier Inc. All rights reserved.

  1. Partial response after intensive chemotherapy for adrenal cortical carcinoma in a child.

    Science.gov (United States)

    Aricò, M; Bossi, G; Livieri, C; Raiteri, E; Severi, F

    1992-01-01

    Adrenocortical carcinoma (ACC) in childhood is a rare tumor with high fatality rate. Available reports provide event free survival rates ranging between 10 to 50%. Optimal treatment has not yet been established; surgery plays a major role, and the value of adjuvant chemotherapy needs to be evaluated further, especially in children who develop recurrent disease and those with metastases at diagnosis. Optimal therapy of ACC has not been established. Surgery has been curative after complete tumor resection. Children with inoperable, recurrent and metastatic ACC have been treated with O,P'DDD, with response rates ranging from 10 to 60% in different series [7,11-20]. Radiotherapy [21] and other anti-cancer drugs have been used [4-22] but their efficacy has not been established. Combination chemotherapy containing oncovin, cisPlatinum, epipodophyllotoxin and cyclophosphamide (OPEC) produced regression of metastatic ACC in a 5-year-old male [23]. We report one girl with relapsed disseminated ACC who showed good, even if temporary, control of the disease, with disappearance of lung, liver and spleen metastases, and marked reduction of the adrenal mass, following combined chemotherapy according to the "eight-drugs-in-one-day" protocol.

  2. Study on the capability of four-level partial response equalization in RSOA-based WDM-PON

    Science.gov (United States)

    Guo, Qi; Tran, An Vu

    2010-12-01

    The expected development of advanced video services with HDTV quality demands the delivery of more than Gb/s link to end users across the last mile connection. Future access networks are also required to have long reach for reduction in the number of central offices (CO). Fueled by those requirements, we propose a novel equalization scheme that increases the capacity and reach of the wavelength division multiplexing passive optical network (WDM-PON) based on a low bandwidth reflective semiconductor optical amplifier (RSOA). We investigate the characteristics of 10 Gb/s upstream transmission in WDM-PON using RSOA with only 1.2 GHz electrical bandwidth and various lengths of fiber. It is proven that the proposed four-level partial response equalizer (PRE) is capable of mitigating the impact of ISI in the received signals from optical network units (ONU) located 0 km to 75 km away from the optical line terminal (OLT).

  3. Application of Response Surface Methodology on Leaching of Iron from Partially Laterised Khondalite Rocks: A Bauxite Mining Waste

    Science.gov (United States)

    Swain, Ranjita; Bhima Rao, R.

    2018-04-01

    In the present investigation, response surface methodology (RSM) is used for a quadratic model that continuously controls the process parameters. This model is used to optimize the removal of iron oxide from Partially Laterised Khondalite (PLK) rocks which is influenced by several independent variables namely acid concentration, time and temperature. Second order response functions are produced for leaching of iron oxide from PLK rocks-a bauxite mining waste. In RSM, Box-Behnken design is used for the process optimization to achieve maximum removal of iron oxide. The influence of the process variables of leaching of iron oxide is presented in the form of 3-D response graphs. The results of this investigation reveals that 3 M hydrochloric acid concentration, 240 min time and 373 K temperature are found to be the best conditions for removal of 99% Fe2O3. The product obtain at this condition contain 80% brightness which is suitable for ceramic and filler industry applications. The novelity of the work is that the waste can be a value added product after suitable physical beneficiation and chemical treatment.

  4. Immune Response and Partial Protection against Heterologous Foot-and-Mouth Disease Virus Induced by Dendrimer Peptides in Cattle

    Directory of Open Access Journals (Sweden)

    I. Soria

    2018-01-01

    Full Text Available Synthetic peptides mimicking protective B- and T-cell epitopes are good candidates for safer, more effective FMD vaccines. Nevertheless, previous studies of immunization with linear peptides showed that they failed to induce solid protection in cattle. Dendrimeric peptides displaying two or four copies of a peptide corresponding to the B-cell epitope VP1 [136–154] of type O FMDV (O/UKG/11/2001 linked through thioether bonds to a single copy of the T-cell epitope 3A [21–35] (termed B2T and B4T, resp. afforded protection in vaccinated pigs. In this work, we show that dendrimeric peptides B2T and B4T can elicit specific humoral responses in cattle and confer partial protection against the challenge with a heterologous type O virus (O1/Campos/Bra/58. This protective response correlated with the induction of specific T-cells as well as with an anamnestic antibody response upon virus challenge, as shown by the detection of virus-specific antibody-secreting cells (ASC in lymphoid tissues distal from the inoculation point.

  5. Application of Response Surface Methodology on Leaching of Iron from Partially Laterised Khondalite Rocks: A Bauxite Mining Waste

    Science.gov (United States)

    Swain, Ranjita; Bhima Rao, R.

    2017-08-01

    In the present investigation, response surface methodology (RSM) is used for a quadratic model that continuously controls the process parameters. This model is used to optimize the removal of iron oxide from Partially Laterised Khondalite (PLK) rocks which is influenced by several independent variables namely acid concentration, time and temperature. Second order response functions are produced for leaching of iron oxide from PLK rocks-a bauxite mining waste. In RSM, Box-Behnken design is used for the process optimization to achieve maximum removal of iron oxide. The influence of the process variables of leaching of iron oxide is presented in the form of 3-D response graphs. The results of this investigation reveals that 3 M hydrochloric acid concentration, 240 min time and 373 K temperature are found to be the best conditions for removal of 99% Fe2O3. The product obtain at this condition contain 80% brightness which is suitable for ceramic and filler industry applications. The novelity of the work is that the waste can be a value added product after suitable physical beneficiation and chemical treatment.

  6. Fluid responsiveness predicted by transcutaneous partial pressure of oxygen in patients with circulatory failure: a prospective study.

    Science.gov (United States)

    Xu, Jingyuan; Peng, Xiao; Pan, Chun; Cai, Shixia; Zhang, Xiwen; Xue, Ming; Yang, Yi; Qiu, Haibo

    2017-12-01

    Significant effort has been devoted to defining parameters for predicting fluid responsiveness. Our goal was to study the feasibility of predicting fluid responsiveness by transcutaneous partial pressure of oxygen (PtcO 2 ) in the critically ill patients. This was a single-center prospective study conducted in the intensive care unit of a tertiary care teaching hospital. Shock patients who presented with at least one clinical sign of inadequate tissue perfusion, defined as systolic blood pressure 40 mmHg in previously hypertensive patients or the need for vasopressive drugs; urine output 4 mmol/l, for less than 24 h in the absence of a contraindication for fluids were eligible to participate in the study. PtcO 2 was continuously recorded before and during a passive leg raising (PLR) test, and then before and after a 250 ml rapid saline infusion in 10 min. Fluid responsiveness is defined as a change in the stroke volume ≥10% after 250 ml of volume infusion. Thirty-four patients were included, and 14 responded to volume expansion. In the responders, the mean arterial pressure, central venous pressure, cardiac output, stroke volume and PtcO 2 increased significantly, while the heart rate decreased significantly by both PLR and volume expansion. Changes in the stroke volume induced either by PLR or volume expansion were significantly greater in responders than in non-responders. The correlation between the changes in PtcO 2 and stroke volume induced by volume expansion was significant. Volume expansion induced an increase in the PtcO 2 of 14% and PLR induced an increase in PtcO 2 of 13% predicted fluid responsiveness. This study suggested the changes in PtcO 2 induced by volume expansion and a PLR test predicted fluid responsiveness in critically ill patients. Trial registration NCT02083757.

  7. The single IGF-1 partial deficiency is responsible for mitochondrial dysfunction and is restored by IGF-1 replacement therapy.

    Science.gov (United States)

    Olleros Santos-Ruiz, M; Sádaba, M C; Martín-Estal, I; Muñoz, U; Sebal Neira, C; Castilla-Cortázar, I

    2017-08-01

    We previously described in cirrhosis and aging, both conditions of IGF-1 deficiency, a clear hepatic mitochondrial dysfunction with increased oxidative damage. In both conditions, the hepatic mitochondrial function was improved with low doses of IGF-1. The aim of this work was to explore if the only mere IGF-1 partial deficiency, without any exogenous insult, is responsible for hepatic mitochondrial dysfunction. Heterozygous (igf1 +/- ) mice were divided into two groups: untreated and treated mice with low doses of IGF-1. WT group was used as controls. Parameters of hepatic mitochondrial function were determined by flow cytometry, antioxidant enzyme activities were determined by spectrophotometry, and electron chain transport enzyme levels were determined by immunohistochemistry and immunofluorescence analyses. Liver expression of genes coding for proteins involved in mitochondrial protection and apoptosis was studied by microarray analysis and RT-qPCR. Hz mice showed a significant reduction in hepatic mitochondrial membrane potential (MMP) and ATPase activity, and an increase in intramitochondrial free radical production and proton leak rates, compared to controls. These parameters were normalized by IGF-1 replacement therapy. No significant differences were found between groups in oxygen consumption and antioxidant enzyme activities, except for catalase, whose activity was increased in both Hz groups. Relevant genes coding for proteins involved in mitochondrial protection and survival were altered in Hz group and were reverted to normal in Hz+IGF-1 group. The mere IGF-1 partial deficiency is per se associated with hepatic mitochondrial dysfunction sensitive to IGF-1 replacement therapy. Results in this work prove that IGF-1 is involved in hepatic mitochondrial protection, because it is able to reduce free radical production, oxidative damage and apoptosis. All these IGF-1 actions are mediated by the modulation of the expression of genes encoding citoprotective

  8. Partial response to sorafenib treatment associated with transient grade 3 thrombocytopenia in a patient with locally advanced thyroid cancer

    Energy Technology Data Exchange (ETDEWEB)

    Pitoia Fabian; Abelleira, Erika; Jerkovich, Fernando; Urciuoli, Carolina; Cross, Graciela, E-mail: fpitoia@intramed.net [Division de Endocrinologia, Hospital de Clinicas, Universidad de Buenos Aires Buenos Aires (Argentina)

    2015-08-15

    Advanced radioactive refractory and progressive or symptomatic differentiated thyroid carcinoma (DTC) is a rare condition. Sorafenib was recently approved for the treatment of these patients. We present the case of a 67 year old woman diagnosed with DTC who underwent a total thyroidectomy with central, lateral-compartment neck dissection and shaving of the trachea and esophagus due to tumor infiltration. A local recurrence was detected 14 months later requiring, additionally, two tracheal rings resection. The patient received a cumulative {sup 131}I dose of 650 mCi and developed dysphagia and dyspnea 63 months after initial surgery. A {sup 18}FGD-PET/CT showed progression of the local mass associated to hypermetabolic pulmonary nodules. Sorafenib 800 mg/day was then prescribed. A dose reduction to 400 mg/day was necessary due to grade 3 thrombocytopenia that appeared four months after drug prescription. Platelet count went to normal after this dose reduction. Five months after initiation of sorafenib, a partial response of the local mass with significant intra-tumoral necrosis was observed. We conclude that sorafenib is a valid option for locally advanced DTC and that the platelet count should be evaluated regularly because it seems that thrombocytopenia might be more frequently observed in DTC than in other types of tumors. (author)

  9. Self-reported impulsivity, but not behavioral choice or response impulsivity, partially mediates the effect of stress on drinking behavior.

    Science.gov (United States)

    Hamilton, Kristen R; Ansell, Emily B; Reynolds, Brady; Potenza, Marc N; Sinha, Rajita

    2013-01-01

    Stress and impulsivity contribute to alcohol use, and stress may also act via impulsivity to increase drinking behavior. Impulsivity represents a multi-faceted construct and self-report and behavioral assessments may effectively capture distinct clinically relevant factors. The present research investigated whether aspects of impulsivity mediate the effect of stress on alcohol use. A community-based sample of 192 men and women was assessed on measures of cumulative stress, alcohol use, self-reported impulsivity, and behavioral choice and response impulsivity. Data were analyzed using regression and bootstrapping techniques to estimate indirect effects of stress on drinking via impulsivity. Cumulative adversity exhibited both direct effects and indirect effects (via self-reported impulsivity) on drinking behavior. Additional models examining specific types of stress indicated direct and indirect effects of trauma and recent life events, and indirect effects of major life events and chronic stressors on drinking behavior. Overall, cumulative stress was associated with increased drinking behavior, and this effect was partially mediated by self-reported impulsivity. Self-reported impulsivity also mediated the effects of different types of stress on drinking behavior. These findings highlight the value of mediation models to examine the pathways through which different types of stress increase drinking behavior. Treatment and prevention strategies should focus on enhancing stress management and self-control.

  10. Oval cell response is attenuated by depletion of liver resident macrophages in the 2-AAF/partial hepatectomy rat.

    Directory of Open Access Journals (Sweden)

    Shuai Xiang

    Full Text Available BACKGROUND/AIMS: Macrophages are known to play an important role in hepatocyte mediated liver regeneration by secreting inflammatory mediators. However, there is little information available on the role of resident macrophages in oval cell mediated liver regeneration. In the present study we aimed to investigate the role of macrophages in oval cell expansion induced by 2-acetylaminofluorene/partial hepatectomy (2-AAF/PH in rats. METHODOLOGY/PRINCIPAL FINDINGS: We depleted macrophages in the liver of 2-AAF/PH treated rats by injecting liposome encapsulated clodronate 48 hours before PH. Regeneration of remnant liver mass, as well as proliferation and differentiation of oval cells were measured. We found that macrophage-depleted rats suffered higher mortality and liver transaminase levels. We also showed that depletion of macrophages yielded a significant decrease of EPCAM and PCK positive oval cells in immunohistochemical stained liver sections 9 days after PH. Meanwhile, oval cell differentiation was also attenuated as a result of macrophage depletion, as large foci of small basophilic hepatocytes were observed by day 9 following hepatectomy in control rats whereas they were almost absent in macrophage depleted rats. Accordingly, real-time polymerase chain reaction analysis showed lower expression of albumin mRNA in macrophage depleted livers. Then we assessed whether macrophage depletion may affect hepatic production of stimulating cytokines for liver regeneration. We showed that macrophage-depletion significantly inhibited hepatic expression of tumor necrosis factor-α and interleukin-6, along with a lack of signal transducer and activator of transcription 3 phosphorylation during the early period following hepatectomy. CONCLUSIONS: These data indicate that macrophages play an important role in oval cell mediated liver regeneration in the 2-AAF/PH model.

  11. Association between competing interests and authors' conclusions

    DEFF Research Database (Denmark)

    Kjaergard, Lise L; Als-Nielsen, Bodil

    2002-01-01

    To assess the association between competing interests and authors' conclusions in randomised clinical trials.......To assess the association between competing interests and authors' conclusions in randomised clinical trials....

  12. A flowing liquid test system for assessing the linearity and time-response of rapid fibre optic oxygen partial pressure sensors.

    Science.gov (United States)

    Chen, R; Hahn, C E W; Farmery, A D

    2012-08-15

    The development of a methodology for testing the time response, linearity and performance characteristics of ultra fast fibre optic oxygen sensors in the liquid phase is presented. Two standard medical paediatric oxygenators are arranged to provide two independent extracorporeal circuits. Flow from either circuit can be diverted over the sensor under test by means of a system of rapid cross-over solenoid valves exposing the sensor to an abrupt change in oxygen partial pressure, P O2. The system is also capable of testing the oxygen sensor responses to changes in temperature, carbon dioxide partial pressure P CO2 and pH in situ. Results are presented for a miniature fibre optic oxygen sensor constructed in-house with a response time ≈ 50 ms and a commercial fibre optic sensor (Ocean Optics Foxy), when tested in flowing saline and stored blood. Copyright © 2012 Elsevier B.V. All rights reserved.

  13. Cost-effectiveness of an atypical conventional antipsychotic in South Africa: An economic evaluation of quetiapine versus haloperidol in the treatment of patients partially responsive to previous antipsychotics

    Directory of Open Access Journals (Sweden)

    Robin Emsley

    2004-10-01

    Full Text Available Background. The introduction of a new generation of atypical antipsychotic agents has raised difficult economic and ethical questions, particularly in lower-income countries. The reported tolerability and efficacy advantages of the atypical antipsy- chotics over their conventional predecessors have to be weighed against their higher acquisition costs. Pharmaco-eco- nomic studies conducted in Western countries consistently report cost advantages or cost neutrality for these new agents. However, considerable differences in health care service pro- vision make it difficult to generalise these findings to South Africa. Method. We compared the direct costs (private and public sector of treating schizophrenia with an atypical antipsychotic quetiapine, and with a conventional antipsychotic haloperidol, by adapting a decision-analytic pharmaco-economic model for South African circumstances. The sample comprised patients partially responsive to antipsychotics, who had partic- ipated in a multinational randomised controlled trial compar- ing the efficacy and safety of quetiapine versus haloperidol. Results. The estimated total direct cost for the treatment with quetiapine in South Africa was slightly less than for haloperidol for various models in both the private and the public sectors. Conclusions. Significant differences in health care provision make pharmaco-economic studies conducted in other coun- tries invalid for South African circumstances. Previously queti- apine treatment did not result in direct cost savings in South Africa. However, the recently introduced legislation to estab- lish single exit prices for medications has resulted in the cost of quetiapine treatment declining by 36.7% and that of haloperi- dol by 13%. This has translated into an overall direct cost sav- ing for quetiapine in both the private and public sector models. This, together with additional indirect advantages of the atypi- cal antipsychotics such as improved quality of

  14. Global Advisory Group: conclusions and recommendations.

    Science.gov (United States)

    1986-02-01

    The conclusions and recommendations formulated for the global program by the 8th meeting of the Expanded Program on Immunization (EPI) Global Advisory Group, which took place during November 1985, are summarized. The Global Advisory Group recommends that, in furtherance of the Five-Point Action Program endorsed by the World Health Assembly in 1983, 3 general and 4 specific actions be taken by national immunization programs with the support of the World Health Organization (WHO) to accelerate EPI progress. These recommendations reflect optimism that the 1990 goal of reducing morbidity and mortality by providing immunization for all children of the world can be realized but also acknowledge that many fundamental problems of national program management remain to be resolved. The general actions are: to promote the achievement of the 1990 immunization goal at national and international levels through collaboration among ministries, organizations, and individuals in both the public and private sectors; to adopt a mix of complementary strategies for program acceleration; and to ensure that rapid increases in coverage can be sustained through mechanisms which strengthen th delivery of other primary health care interventions. The specific actions are as follows: to provide immunization at every contact point; to reduce dropout rates between 1st and last immunizations; to improve immunization services to the disadvantaged in urban areas; and to increase priority for the control of measles, poliomyelitis, and neonatal tetanus. The WHO and the UN International Children's Emergency Fund (UNICEF) have collaborated in support of the EPI since the early days of the program. The acceleration of national efforts heightens the importance of this collaboration, particularly at the national level. It may be further facilitated by the provision of policy guidance from global and regional levels, by WHO and UNICEF collaborative agreements at the regional level, and by country agreements

  15. Data, Model, Conclusions, Doing It Again.

    Science.gov (United States)

    Molenaar, Ivo W.

    1998-01-01

    Explores the robustness of conclusions from a statistical model against variations in model choice with an illustration from G. Box and G. Tiao (1973). Suggests that simultaneous consideration of a class of models for the same data is sometimes superior to analyzing the data under one model and demonstrates advantages to Adaptive Bayesian…

  16. Premature conclusions about psychotherapy for dysthymia

    NARCIS (Netherlands)

    Cuijpers, P.

    2009-01-01

    Dr Cuijpers and Colleagues Reply To the Editor: We thank Dr Gaudiano and colleagues for their contribution to the discussion about psychotherapy for dysthymia. We agree very much with Gaudiano et al that we should be careful about drawing definite conclusions about the comparative efficacy of

  17. Data, model, conclusion, doing it again

    NARCIS (Netherlands)

    Molenaar, W.

    1998-01-01

    This paper explores the robustness of conclusions from a statistical model against variations in model choice (rather than variations in random sampling and random assignment to treatments, which are the usual variations covered by inferential statistics). After the problem formulation in section 1,

  18. Results and conclusion; Resultados e conclusoes

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-10-15

    This chapter shows the results and conclusions of the ordered studies by the Science and Technology Ministry from Brazil to the Center of Management and Strategic Studies (CGEE), executed by a multidisciplinary team, most of UNICAMP - State University of Campinas, SP - for evaluation of Brazilian capacity and potential in the production of fuel bioethanol.

  19. Can Repeat Injection Provide Clinical Benefit in Patients with Lumbosacral Diseases When First Epidural Injection Results Only in Partial Response?

    Science.gov (United States)

    Lee, Jung Hwan; Lee, Sang-Ho

    2016-02-01

    Epidural steroid injection (ESI) is known to be an effective treatment for lower back or radicular pain due to herniated intervertebral disc (HIVD) and spinal stenosis (SS). Although repeat ESI has generally been indicated to provide more pain relief in partial responders after a single ESI, there has been little evidence supporting the usefulness of repeat injections in cumulative clinical pain reduction. The purpose of this study was to determine whether repeat ESI at a prescribed interval of 2 to 3 weeks after the first injection would provide greater clinical benefit in patients with partial pain reduction than that provided by intermittent injection performed only when pain was aggravated. An Institutional Review Board (IRB)-approved retrospective chart review. Spine hospital. Two hundred and four patients who had underwent transforaminal ESI (TFESI) for treatment of lower back and radicular pain due to HIVD or SS and could be followed-up for one year were enrolled. We divided the patients into 2 groups. Group A (N = 108) comprised partial responders (NRS = 3 after first injection) who underwent repeat injection at a prescribed interval of 2 to 3 weeks after the first injection. Group B (N = 96) comprised partial responders who did not receive a repeat injection at the prescribed interval, but received repeat injections only for aggravation of pain. Various clinical data including total number of injections during one year, duration of NRS group A, or after first injection in group B (time to reinjection), were assessed. These data were compared between groups A and B in terms of total population, HIVD, and SS. In the whole population, the mean time to reinjection was 6.09 ± 3.02 months in group A and 3.69 ± 2.07 months in group B. The NRS groups A and B, respectively. In HIVD patients, the mean time to reinjection was 5.82 ± 3.23 months in group A and 3.84 ± 2.34 months in group B, and NRS groups A and B, respectively. In SS patients, the mean time to

  20. Superiority in value and the repugnant conclusion

    DEFF Research Database (Denmark)

    Jensen, Karsten Klint

    2007-01-01

    superiority does not amount to a radical value difference at all. I then spell out the consequences of these results for different interpretations of Griffin's suggestion regarding population ethics. None of them comes out very successful, but perhaps they nevertheless retain some interest.......James Griffin has considered a weak form of superiority in value a possible remedy to the Repugnant Conclusion. In this paper, I demonstrate that, in a context where value is additive, this weaker form collapses into a stronger form of superiority. And in a context where value is non-additive, weak...

  1. Diurnal pattern of serum BDNF before partial sleep deprivation in stress-related mood disorders – an association with therapy response in major depression

    Directory of Open Access Journals (Sweden)

    Maria Giese

    2012-09-01

    improved mood in all depressive patients. In addition, placebo treated patients during PSD exhibited a significant increase of serum cortisol levels during PSD when compared to morning peak levels at 8 am between day one and two. There was no serum cortisol increase in the modafinil treated group during PSD intervention. Conclusions : Altogether, it seems that a diurnal pattern of serum BDNF during the day is necessarily associated with acute and response after two weeks in terms of partial sleep deprivation independently from additional treatment (modafinil vs. placebo. BDNF levels peaking in the morning and declining during the day seem to be favourable for an antidepressant response. Therefore, BDNF expression profile in serum at baseline could be used as possible predictor for therapy outcome.

  2. Terrestrial lichen response to partial cutting in lodgepole pine forests on caribou winter range in west-central British Columbia

    Directory of Open Access Journals (Sweden)

    Michaela J. Waterhouse

    2011-09-01

    Full Text Available In west-central British Columbia, terrestrial lichens located in older, lodgepole pine (Pinus contorta forests are important winter forage for woodland caribou (Rangifer tarandus caribou. Clearcut harvesting effectively removes winter forage habitat for decades, so management approaches based on partial cutting were designed to maintain continuous lichen-bearing habitat for caribou. This study tested a group selection system, based on removal of 33% of the forest every 80 years in small openings (15 m diameter, and two irregular shelterwood treatments (whole-tree and stem-only harvesting methods where 50% of the stand area is cut every 70 years in 20 to 30 m diameter openings. The abundance of common terrestrial lichens among the partial cutting and no-harvest treatments was compared across five replicate blocks, pre-harvest (1995 and post-harvest (1998, 2000 and 2004. The initial loss of preferred forage lichens (Cladonia, Cladina, Cetraria and Stereocaulon was similar among harvesting treatments, but there was greater reduction in these lichens in the openings than in the residual forest. After eight years, forage lichens in the group selection treatment recovered to pre-harvest amounts, while lichen in the shelterwood treatments steadily increased from 49 to 57% in 1998 to about 70% of pre-harvest amounts in 2004. Although not part of the randomized block design, there was substantially less lichen in three adjacent clearcut blocks than in the partial cuts. Regression analysis pre- and post-harvest indicated that increased cover of trees, shrubs, herbs, woody debris and logging slash corresponded with decreased forage lichen abundance. In the short-term, forestry activities that minimize inputs of woody debris, control herb and shrub development, and moderate the changes in light and temperatures associated with canopy removal will lessen the impact on lichen. Implementation of stand level prescriptions is only one aspect of caribou habitat

  3. Effect of partial and complete variable loop deletions of the human immunodeficiency virus type 1 envelope glycoprotein on the breadth of gp160-specific immune responses

    International Nuclear Information System (INIS)

    Gzyl, Jaroslaw; Bolesta, Elizabeth; Wierzbicki, Andrew; Kmieciak, Dariusz; Naito, Toshio; Honda, Mitsuo; Komuro, Katsutoshi; Kaneko, Yutaro; Kozbor, Danuta

    2004-01-01

    Induction of cross-reactive cellular and humoral responses to the HIV-1 envelope (env) glycoprotein was examined after DNA immunization of BALB/c mice with gp140 89.6 -derived constructs exhibiting partial or complete deletions of the V1, V2, and V3 domains. It was demonstrated that specific modification of the V3 loop (mV3) in combination with the V2-modified (mV2) or V1/V2-deleted (ΔV1/V2) region elicited increased levels of cross-reactive CD8 + T cell responses. Mice immunized with the mV2/mV3 or ΔV1/V2/mV3 gp140 89.6 plasmid DNA were greater than 50-fold more resistant to challenge with recombinant vaccinia virus (rVV) expressing heterologous env gene products than animals immunized with the wild-type (WT) counterpart. Sera from mV2/mV3- and ΔV1/V2/mV3-immunized mice exhibited the highest cross-neutralizing activity and displayed intermediate antibody avidity values which were further enhanced by challenge with rVV expressing the homologous gp160 glycoprotein. In contrast, complete deletion of the variable regions had little or no effect on the cross-reactive antibody responses. The results of these experiments indicate that the breadth of antibody responses to the HIV-1 env glycoprotein may not be increased by removal of the variable domains. Instead, partial deletions within these regions may redirect specific responses toward conserved epitopes and facilitate approaches for boosting cross-reactive cellular and antibody responses to the env glycoprotein

  4. Growth Response of Northern White-Cedar (Thuja occidentalis to Natural Disturbances and Partial Cuts in Mixedwood Stands of Quebec, Canada

    Directory of Open Access Journals (Sweden)

    Jean-Claude Ruel

    2014-05-01

    Full Text Available Northern white-cedar (Thuja occidentalis is a species of high commercial and ecological value, the abundance of which has been declining since the middle of the 19th century. Very little information regarding its silviculture in mixedwood stands is currently available, even though a significant portion of wood resources comes from these stands. The present study is a retrospective analysis of white-cedar growth in partially harvested mixedwood stands of western Quebec, Canada. Eight stands distributed across two regions were analyzed. Dendrochronological approaches examined long-term diameter growth for sample white-cedar trees and stems of associated species. These approaches were used to reconstruct stand characteristics at the time of harvesting, together with local harvesting intensity. The study demonstrated white-cedar’s capacity to maintain good growth for long periods of time and at large tree sizes. Accession to the upper canopy positions occurs through repeated episodes of suppression/release, most of which seem to be associated with spruce budworm (Choristoneura fumiferana outbreaks. White-cedar response to partial harvesting varies with tree size, residual basal area and species composition. Growth response was generally stronger for small trees, even though large trees still maintained the best diameter growth. Growth of white-cedar was negatively affected by an increase in softwood proportion in basal area. Growth responses to harvesting could be sustained for a period of 20 years.

  5. RELAP5 assessment: conclusions and user guidelines

    International Nuclear Information System (INIS)

    Kmetyk, L.N.

    1984-10-01

    The RELAP5 independent assessment project at Sandia National Laboratories is part of an overall effort funded by the NRC to determine the ability of various systems codes to predict the detailed thermal/hydraulic response of LWRs during accident and off-normal conditions. The RELAP5/MOD1 code has been assessed at Sandia against a variety of test data from both integral and separate effects test facilities. All these analyses have been documented in detail in individual topical reports; in this paper we attempt to evaluate the overall code performance by comparing results from many different calculations, and to offer other users some guidelines based on our experience to date

  6. Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans.

    Science.gov (United States)

    Carroll, Judith E; Cole, Steven W; Seeman, Teresa E; Breen, Elizabeth C; Witarama, Tuff; Arevalo, Jesusa M G; Ma, Jeffrey; Irwin, Michael R

    2016-01-01

    Age-related disease risk has been linked to short sleep duration and sleep disturbances; however, the specific molecular pathways linking sleep loss with diseases of aging are poorly defined. Key cellular events seen with aging, which are thought to contribute to disease, may be particularly sensitive to sleep loss. We tested whether one night of partial sleep deprivation (PSD) would increase leukocyte gene expression indicative of DNA damage responses (DDR), the senescence-associated secretory phenotype (SASP), and senescence indicator p16(INK4a) in older adult humans, who are at increased risk for cellular senescence. Community-dwelling older adults aged 61-86years (n=29; 48% male) underwent an experimental partial sleep deprivation (PSD) protocol over 4 nights, including adaptation, an uninterrupted night of sleep, partial sleep deprivation (sleep restricted 3-7AM), and a subsequent full night of sleep. Blood samples were obtained each morning to assess peripheral blood mononuclear cell (PBMC) gene expression using Illumina HT-12 arrays. Analyses of microarray results revealed that SASP (psleep deprivation activates PBMC gene expression patterns consistent with biological aging in this older adult sample. PSD enhanced the SASP and increased the accumulation of damage that initiates cell cycle arrest and promotes cellular senescence. These findings causally link sleep deprivation to the molecular processes associated with biological aging. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. Parental Catastrophizing Partially Mediates the Association between Parent-Reported Child Pain Behavior and Parental Protective Responses

    OpenAIRE

    Langer, Shelby L.; Romano, Joan M.; Mancl, Lloyd; Levy, Rona L.

    2014-01-01

    This study sought to model and test the role of parental catastrophizing in relationship to parent-reported child pain behavior and parental protective (solicitous) responses to child pain in a sample of children with Inflammatory Bowel Disease and their parents (n = 184 dyads). Parents completed measures designed to assess cognitions about and responses to their child's abdominal pain. They also rated their child's pain behavior. Mediation analyses were performed using regression-based techn...

  8. [The effect of partial liquid ventilation on inflammatory response in piglets with acute lung injury induced by lipopolysaccharide].

    Science.gov (United States)

    Tang, Jin; Zhang, Jie; Li, Xuguang; Guo, Zhongliang

    2014-02-01

    To evaluate the effect of partial liquid ventilation (PLV) on pro-inflammatory and anti-inflammatory factors change in lipopolysaccharide (LPS)-induced piglets acute lung injury (ALI). Twelve Shanghai white piglets were randomly divided into mechanical ventilation (MV) group (n=6) and PLV group (n=6). 60 μg×kg(-1)×h(-1) LPS were intravenous infused continuously for 2 hours to induce ALI model. PLV model was set on the basis of the MV by endotracheal injection of perfluorodecalin (PFC, 10 mL/kg). The hemodynamic and respiratory parameters such as mechanics and arterial blood gas analysis were monitored at basic condition and after lung injury establishment (0, 1, 2, 4 hours). The serum levels of interleukin (IL-1β, IL-6, IL-8, IL-10) and tumor necrosis factor-α (TNF-α) were dynamically monitored by enzyme linked immunosorbent assay (ELISA). A lung injury score was used to quantify lung tissues change under light microscopic observations. Ventilation and oxygenation function were improved gradually after PFC endotracheal injection in PLV group, and there were significant difference compared with MV group at 4 hours [heart rate (HR): 144 ± 6 beats/min vs. 179 ± 9 beats/min, respiratory rate (RR): 58 ± 4 beats/min vs. 77 ± 6 beats/min, mean arterial blood pressure (MAP): 99 ± 7 mmHg vs. 75 ± 29 mmHg, dynamic lung compliance (Cdyn): 1.9 ± 0.3 mL×cmH(2)O(-1)×kg(-1) vs. 1.2 ± 0.4 mL×cmH(2)O(-1)×kg(-1), tidal volume (VT): 7.8 ± 0.4 mL/kg vs. 5.8 ± 0.9 mL/kg, mean airway resistance (Raw): 20.5 ± 6.6 cmH(2)O×L(-1)×s(-1) vs. 35.2 ± 4.0 cmH(2)O×L(-1)×s(-1), mean airway pressure (Paw): 1.0 ± 0.5 cmH(2)O vs. 3.0 ± 0.9 cmH(2)O, ventilation efficacy index (VEI): 0.18 ± 0.02 vs. 0.08 ± 0.02, pH value: 7.386 ± 0.143 vs. 7.148 ± 0.165, arterial partial pressure of oxygen (PaO(2)): 121.8 ± 12.5 mmHg vs. 73.6 ± 10.9 mmHg, arterial partial pressure of carbon dioxide (PaCO(2)): 39.6 ± 20.3 mmHg vs. 66.8 ± 23.5 mmHg, oxygenation index (PaO(2)/FiO(2

  9. Parasympathetic activity and blood catecholamine responses following a single partial-body cryostimulation and a whole-body cryostimulation.

    Directory of Open Access Journals (Sweden)

    Christophe Hausswirth

    Full Text Available The aim of this study was to compare the effects of a single whole-body cryostimulation (WBC and a partial-body cryostimulation (PBC (i.e., not exposing the head to cold on indices of parasympathetic activity and blood catecholamines. Two groups of 15 participants were assigned either to a 3-min WBC or PBC session, while 10 participants constituted a control group (CON not receiving any cryostimulation. Changes in thermal, physiological and subjective variables were recorded before and during the 20-min after each cryostimulation. According to a qualitative statistical analysis, an almost certain decrease in skin temperature was reported for all body regions immediately after the WBC (mean decrease±90% CL, -13.7±0.7°C and PBC (-8.3±0.3°C, which persisted up to 20-min after the session. The tympanic temperature almost certainly decreased only after the WBC session (-0.32±0.04°C. Systolic and diastolic blood pressures were very likely increased after the WBC session, whereas these changes were trivial in the other groups. In addition, heart rate almost certainly decreased after PBC (-10.9% and WBC (-15.2% sessions, in a likely greater proportion for WBC compared to PBC. Resting vagal-related heart rate variability indices (the root-mean square difference of successive normal R-R intervals, RMSSD, and high frequency band, HF were very likely increased after PBC (RMSSD: +54.4%, HF: +138% and WBC (RMSSD: +85.2%, HF: +632% sessions without any marked difference between groups. Plasma norepinephrine concentrations were likely to very likely increased after PBC (+57.4% and WBC (+76.2%, respectively. Finally, cold and comfort sensations were almost certainly altered after WBC and PBC, sensation of discomfort being likely more pronounced after WBC than PBC. Both acute cryostimulation techniques effectively stimulated the autonomic nervous system (ANS, with a predominance of parasympathetic tone activation. The results of this study also suggest

  10. Only one simple conclusion about the climate

    Energy Technology Data Exchange (ETDEWEB)

    Jaremko, G.

    2000-07-24

    Findings concerning climate change, by a three-man team of scientists from the North Dakota Geological Survey, which were presented in a paper read at the Eight International Williston Basin Horizontal Well Workshop, are discussed. The survey by the three scientists covered more than 6,000 scholarly publications. It reported that while the rise in the Earth's temperature is beyond argument, there is anything but agreement as to the causes, or whether the trend is unusual enough to justify concerted and costly actions to change lifestyles. It is shown by direct instrumental measurements that the average temperature at the Earth's surface increased about 0.8 degree Celsius between 1866 and 1998. During that time the concentration of carbon dioxide in the atmosphere increased from 280 to 353 parts per million. While it is generally assumed that the global warming was caused by human activities, new techniques of measurement such as glacier ice coring, dendrochronology (tree-growth rings), lichenometry (measuring the diameter of lichens) and counting concentrations of oxygen 18 and 16 (isotopes whose presence in marine fossils varies depending on temperature) suggest that most of the global warming took place before the increase in carbon dioxide concentration occurred, raising the possibility that the increase in average temperature had causes other than the increase in greenhouse gases. Some of the studies reviewed by the group show that in Europe between ice ages during the Eemian period, some 135,000 to 110,000 years ago, temperature variations of seven degrees Celsius took place; they dropped from two degree Celsius warmer than today to five degree Celsius colder than today. Based on these findings the group's only firm conclusion was that climate is in a continual flux.

  11. Responses of wild small mammals to arsenic pollution at a partially remediated mining site in Southern France.

    Science.gov (United States)

    Drouhot, Séverine; Raoul, Francis; Crini, Nadia; Tougard, Christelle; Prudent, Anne-Sophie; Druart, Coline; Rieffel, Dominique; Lambert, Jean-Claude; Tête, Nicolas; Giraudoux, Patrick; Scheifler, Renaud

    2014-02-01

    Partial remediation actions at a former gold mine in Southern France led to a mosaic of contaminated and rehabilitated zones. In this study, the distribution of arsenic and its potential adverse effects on small mammals were investigated. The effectiveness of remediation for reducing the transfer of this element into wildlife was also discussed. Arsenic levels were measured in the soil and in the stomach contents, livers, kidneys, and lungs of four small mammal species (the wood mouse (Apodemus sylvaticus), the Algerian mouse (Mus spretus), the common vole (Microtus arvalis), and the greater white-toothed shrew (Crocidura russula)). The animals were caught at the former extraction site, in zones with three different levels of remediation treatments, and at a control site. Arsenic concentrations in the soil were highly spatially heterogeneous (ranging from 29 to 18,900 μg g(-1)). Despite the decrease in arsenic concentrations in the remediated soils, both wood mice and Algerian mice experienced higher oral exposure to arsenic in remediated zones than in the control area. The accumulated arsenic in their organs showed higher intra-zonal variability than the arsenic distribution in the soil, suggesting that, in addition to remediation processes, other variables can help explain arsenic transfer to wildlife, such as the habitat and diet preferences of the animals or their mobility. A weak but significant correlation between arsenic concentration and body condition was observed, and weak relationships between the liver/kidney/lung mass and arsenic levels were also detected, suggesting possible histological alterations. © 2013.

  12. Structure of the lamin A/C R482W mutant responsible for dominant familial partial lipodystrophy (FPLD)

    Energy Technology Data Exchange (ETDEWEB)

    Magracheva, Eugenia; Kozlov, Serguei; Stewart, Colin L.; Wlodawer, Alexander; Zdanov, Alexander; (NCI)

    2009-08-07

    Proteins of the A-type lamin family, which consists of two members, lamin A and lamin C, are the major components of a thin proteinaceous filamentous meshwork, the lamina, that underlies the inner nuclear membrane. A-type lamins have recently become the focus of extensive functional studies as a consequence of the linking of at least eight congenital diseases to mutations in the lamin A/C gene (LMNA). This spectrum of pathologies, which mostly manifest themselves as dominant traits, includes muscle dystrophies, dilated cardiomyopathies, the premature aging syndrome Hutchinson-Guilford progeria and familial partial lipodystrophy (FPLD). The crystal structure of the lamin A/C mutant R482W, a variant that causes FPLD, has been determined at 1.5 {angstrom} resolution. A completely novel aggregation state of the C-terminal globular domain and the position of the mutated amino-acid residue suggest means by which the mutation may affect lamin A/C-protein and protein-DNA interactions.

  13. Venturing into the private sector: Conclusion

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    From the very beginning, HEU has been a government-to-government deal. And right fully so. These weapons were produced by the US and Russia over the course of the Cold War. The two superpowers should play the main role in their dismantlement. After all, these aren't cars or microcomputers we're talking about. They are weapons of mass destruction. One day, private business will profit from their dismantlement. But it is truly the responsibility of the US and Russian governments to accomplish the larger objective of the HEU deal: To destroy these weapons, once and for all. But if government can fulfill the role of moral overseer, there's no reason why the private sector should not be involved in implementing the plan. And there is no shortage of companies lining up for a piece of the business. The Russians are all ears. While a deal with the US is their main priority, they've spoken to a number of private companies about blending down and marketing the HEU. In recent months, several US companies have signed preliminary agreements with the Russians. But what actual business these agreements will lead to is very unclear

  14. The Financial Crisis: Origins, Causes And Conclusions

    Directory of Open Access Journals (Sweden)

    Eneida Permeti

    2015-03-01

    Full Text Available The crisis in recent years took start in response to a crisis of the real estate market in the United States in 2007. The year 2009 has seen an economic crisis and between 2010 and 2011 it was known the spreading of the crisis sovereign debt and public finances of many countries. The financial markets failed in their main task: the allocation of risk. The products and services traded in the financial market are characterized by the immateriality and legal complexity. It means a high uncertainty degree and a high risk. Therefore is very important to protect the investors and this means: give them the right information, right legislation, market confidence and a product that respond to their needs. The crisis causes are: weaknesses in the regulatory, malfunction of the rating agencies, political errors and conflicts of interest. This means that we need: more rules, more capital, less debt, more transparency. The financial markets and the economy have always moved in harmony and savers have undertaken a countercyclical behavior, against trend or against the cycle and for investing in financial markets with the probability in favor we need a map that comes from the statistics.

  15. Partial Cancellation

    Indian Academy of Sciences (India)

    First page Back Continue Last page Overview Graphics. Partial Cancellation. Full Cancellation is desirable. But complexity requirements are enormous. 4000 tones, 100 Users billions of flops !!! Main Idea: Challenge: To determine which cross-talker to cancel on what “tone” for a given victim. Constraint: Total complexity is ...

  16. Partial demethylation of oligogalacturonides by pectin methyl esterase 1 is required for eliciting defence responses in wild strawberry (Fragaria vesca).

    Science.gov (United States)

    Osorio, Sonia; Castillejo, Cristina; Quesada, Miguel A; Medina-Escobar, Nieves; Brownsey, Geoff J; Suau, Rafael; Heredia, Antonio; Botella, Miguel A; Valpuesta, Victoriano

    2008-04-01

    In addition to the role of the cell wall as a physical barrier against pathogens, some of its constituents, such as pectin-derived oligogalacturonides (OGA), are essential components for elicitation of defence responses. To investigate how modifications of pectin alter defence responses, we expressed the fruit-specific Fragaria x ananassa pectin methyl esterase FaPE1 in the wild strawberry Fragaria vesca. Pectin from transgenic ripe fruits differed from the wild-type with regard to the degree and pattern of methyl esterification, as well as the average size of pectin polymers. Purified oligogalacturonides from the transgenic fruits showed a reduced degree of esterification compared to oligogalacturonides from wild-type fruits. This reduced esterification is necessary to elicit defence responses in strawberry. The transgenic F. vesca lines had constitutively activated pathogen defence responses, resulting in higher resistance to the necrotropic fungus Botrytis cinerea. Further studies in F. vesca and Nicotiana benthamiana leaves showed that the elicitation capacity of the oligogalacturonides is more specific than previously envisaged.

  17. Conclusions: environmental change, wildlife conservation and reproduction.

    Science.gov (United States)

    Holt, William V; Brown, Janine L; Comizzoli, Pierre

    2014-01-01

    Our intention when planning this book was to explore the diverse ways that reproductive science is inextricably tied to many aspects of biodiversity conservation, using the opportunity to present a vast amount of specialised information in a way that forms a coherent and important body of work. Some of the chapters were therefore concerned with understanding how taxonomic groups and species are being affected by globally important environmental changes, mostly caused through anthropogenic influences. Others were more focused on monitoring and understanding the physiology of wild species, with the aim of better understanding mechanisms underlying responses to captive conditions and environmental change, in both wild and captive animals. We also wanted to review advances in technological measures that are being actively developed to support the breeding and management of wildlife. In a few cases we have presented specific case studies that highlight the amount of effort required for the successful development of assisted reproductive technologies for wild species. Viewed overall, the outcome is spectacular; the last decade has seen enormous progress in many aspects of the sciences and technologies relevant to the topic. It is also clear that the boundaries between different scientific disciplines are becoming ever more blurred, and it is no longer easy or even possible to remain focused on a highly specialized topic in reproduction or conservation, without having at least some understanding of allied subjects. Here we present a few concluding comments about what we have learnt, and how the various topics interact with each other. We also emphasize that, as far as we know, no similarly comprehensive consideration of the contribution of reproductive science to wildlife conservation has been published within the last decade.

  18. Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals.

    Science.gov (United States)

    Benedict, Christian; Vogel, Heike; Jonas, Wenke; Woting, Anni; Blaut, Michael; Schürmann, Annette; Cedernaes, Jonathan

    2016-12-01

    Changes to the microbial community in the human gut have been proposed to promote metabolic disturbances that also occur after short periods of sleep loss (including insulin resistance). However, whether sleep loss affects the gut microbiota remains unknown. In a randomized within-subject crossover study utilizing a standardized in-lab protocol (with fixed meal times and exercise schedules), we studied nine normal-weight men at two occasions: after two nights of partial sleep deprivation (PSD; sleep opportunity 02:45-07:00 h), and after two nights of normal sleep (NS; sleep opportunity 22:30-07:00 h). Fecal samples were collected within 24 h before, and after two in-lab nights, of either NS or PSD. In addition, participants underwent an oral glucose tolerance test following each sleep intervention. Microbiota composition analysis (V4 16S rRNA gene sequencing) revealed that after two days of PSD vs. after two days of NS, individuals exhibited an increased Firmicutes:Bacteroidetes ratio, higher abundances of the families Coriobacteriaceae and Erysipelotrichaceae, and lower abundance of Tenericutes (all P < 0.05) - previously all associated with metabolic perturbations in animal or human models. However, no PSD vs. NS effect on beta diversity or on fecal short-chain fatty acid concentrations was found. Fasting and postprandial insulin sensitivity decreased after PSD vs. NS (all P < 0.05). Our findings demonstrate that short-term sleep loss induces subtle effects on human microbiota. To what extent the observed changes to the microbial community contribute to metabolic consequences of sleep loss warrants further investigations in larger and more prolonged sleep studies, to also assess how sleep loss impacts the microbiota in individuals who already are metabolically compromised.

  19. Identifying cochlear implant channels with poor electrode-neuron interfaces: electrically evoked auditory brain stem responses measured with the partial tripolar configuration.

    Science.gov (United States)

    Bierer, Julie Arenberg; Faulkner, Kathleen F; Tremblay, Kelly L

    2011-01-01

    The goal of this study was to compare cochlear implant behavioral measures and electrically evoked auditory brain stem responses (EABRs) obtained with a spatially focused electrode configuration. It has been shown previously that channels with high thresholds, when measured with the tripolar configuration, exhibit relatively broad psychophysical tuning curves. The elevated threshold and degraded spatial/spectral selectivity of such channels are consistent with a poor electrode-neuron interface, defined as suboptimal electrode placement or reduced nerve survival. However, the psychophysical methods required to obtain these data are time intensive and may not be practical during a clinical mapping session, especially for young children. Here, we have extended the previous investigation to determine whether a physiological approach could provide a similar assessment of channel functionality. We hypothesized that, in accordance with the perceptual measures, higher EABR thresholds would correlate with steeper EABR amplitude growth functions, reflecting a degraded electrode-neuron interface. Data were collected from six cochlear implant listeners implanted with the HiRes 90k cochlear implant (Advanced Bionics). Single-channel thresholds and most comfortable listening levels were obtained for stimuli that varied in presumed electrical field size by using the partial tripolar configuration, for which a fraction of current (σ) from a center active electrode returns through two neighboring electrodes and the remainder through a distant indifferent electrode. EABRs were obtained in each subject for the two channels having the highest and lowest tripolar (σ = 1 or 0.9) behavioral threshold. Evoked potentials were measured with both the monopolar (σ = 0) and a more focused partial tripolar (σ ≥ 0.50) configuration. Consistent with previous studies, EABR thresholds were highly and positively correlated with behavioral thresholds obtained with both the monopolar and partial

  20. Effects of VIE tagging and partial tissue sampling on the immune response of three-spined stickleback Gasterosteus aculeatus.

    Science.gov (United States)

    Henrich, T; Hafer, N; Mobley, K B

    2014-09-01

    A 14 day experiment on effects of visible implant elastomer (VIE) tagging and spine-clipping of three-spined stickleback Gasterosteus aculeatus showed significant increases in immune response, particularly in the granulocyte:lymphocyte ratio, in both treatments and the sham control. A minimum two-week recovery after handling, anaesthesia, tagging and spine-clipping is recommended to minimize effect of manipulation on the immune system. © 2014 The Fisheries Society of the British Isles.

  1. Inflammatory Murine Skin Responses to UV-B Light Are Partially Dependent on Endothelin-1 and Mast Cells

    OpenAIRE

    Metz, Martin; Lammel, Verena; Gibbs, Bernhard F.; Maurer, Marcus

    2006-01-01

    Endothelin (ET-1) has been shown to crucially contribute to UV-induced skin responses such as tanning. To test whether ET-1 is also involved in early cutaneous reactions to UV, we assessed ET-1 skin levels in UV-irradiated mice. In correlation with the levels of UV-induced skin inflammation, ET-1 concentrations increased substantially and continually. Moreover, blocking of ET-1 receptors (ETA) resulted in significantly decreased cutaneous inflammation following UV irradiation. When we assesse...

  2. Can a mathematical model predict an individual's trait-like response to both total and partial sleep loss?

    Science.gov (United States)

    Ramakrishnan, Sridhar; Lu, Wei; Laxminarayan, Srinivas; Wesensten, Nancy J; Rupp, Tracy L; Balkin, Thomas J; Reifman, Jaques

    2015-06-01

    Humans display a trait-like response to sleep loss. However, it is not known whether this trait-like response can be captured by a mathematical model from only one sleep-loss condition to facilitate neurobehavioural performance prediction of the same individual during a different sleep-loss condition. In this paper, we investigated the extent to which the recently developed unified mathematical model of performance (UMP) captured such trait-like features for different sleep-loss conditions. We used the UMP to develop two sets of individual-specific models for 15 healthy adults who underwent two different sleep-loss challenges (order counterbalanced; separated by 2-4 weeks): (i) 64 h of total sleep deprivation (TSD) and (ii) chronic sleep restriction (CSR) of 7 days of 3 h nightly time in bed. We then quantified the extent to which models developed using psychomotor vigilance task data under TSD predicted performance data under CSR, and vice versa. The results showed that the models customized to an individual under one sleep-loss condition accurately predicted performance of the same individual under the other condition, yielding, on average, up to 50% improvement over non-individualized, group-average model predictions. This finding supports the notion that the UMP captures an individual's trait-like response to different sleep-loss conditions. © 2014 European Sleep Research Society.

  3. Postprandial nutrient-sensing and metabolic responses after partial dietary fishmeal replacement by soyabean meal in turbot (Scophthalmus maximus L.).

    Science.gov (United States)

    Xu, Dandan; He, Gen; Mai, Kangsen; Zhou, Huihui; Xu, Wei; Song, Fei

    2016-02-14

    In this study, we chose a carnivorous fish, turbot (Scophthalmus maximus L.), to examine its nutrient-sensing and metabolic responses after ingestion of diets with fishmeal (FM), or 45% of FM replaced by soyabean meal (34·6% dry diet) balanced with or without essential amino acids (EAA) to match the amino acid profile of FM diet for 30 d. After a 1-month feeding trial, fish growth, feed efficiency and nutrient retention were markedly reduced by soyabean meal-incorporated (SMI) diets. Compared with the FM diet, SMI led to a reduction of postprandial influx of free amino acids, hypoactivated target of rapamycin signalling and a hyperactivated amino acid response pathway after refeeding, a status associated with reduced protein synthesis, impaired postprandial glycolysis and lipogenesis. These differential effects were not ameliorated by matching an EAA profile of soyabean meal to that of the FM diet through dietary amino acid supplementation. Therefore, this study demonstrated that the FM diet and SMI diets led to distinct nutrient-sensing responses, which in turn modulated metabolism and determined the utilisation efficiency of diets. Our results provide a new molecular explanation for the role of nutrient sensing in the inferior performance of aquafeeds in which FM is replaced by soyabean meal.

  4. Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals

    Directory of Open Access Journals (Sweden)

    Christian Benedict

    2016-12-01

    Full Text Available Objective: Changes to the microbial community in the human gut have been proposed to promote metabolic disturbances that also occur after short periods of sleep loss (including insulin resistance. However, whether sleep loss affects the gut microbiota remains unknown. Methods: In a randomized within-subject crossover study utilizing a standardized in-lab protocol (with fixed meal times and exercise schedules, we studied nine normal-weight men at two occasions: after two nights of partial sleep deprivation (PSD; sleep opportunity 02:45–07:00 h, and after two nights of normal sleep (NS; sleep opportunity 22:30–07:00 h. Fecal samples were collected within 24 h before, and after two in-lab nights, of either NS or PSD. In addition, participants underwent an oral glucose tolerance test following each sleep intervention. Results: Microbiota composition analysis (V4 16S rRNA gene sequencing revealed that after two days of PSD vs. after two days of NS, individuals exhibited an increased Firmicutes:Bacteroidetes ratio, higher abundances of the families Coriobacteriaceae and Erysipelotrichaceae, and lower abundance of Tenericutes (all P < 0.05 – previously all associated with metabolic perturbations in animal or human models. However, no PSD vs. NS effect on beta diversity or on fecal short-chain fatty acid concentrations was found. Fasting and postprandial insulin sensitivity decreased after PSD vs. NS (all P < 0.05. Discussion: Our findings demonstrate that short-term sleep loss induces subtle effects on human microbiota. To what extent the observed changes to the microbial community contribute to metabolic consequences of sleep loss warrants further investigations in larger and more prolonged sleep studies, to also assess how sleep loss impacts the microbiota in individuals who already are metabolically compromised. Author Video: Author Video Watch what authors say about their articles Keywords: Bacteroidetes, Firmicutes, Insulin resistance

  5. Partial processing

    International Nuclear Information System (INIS)

    1978-11-01

    This discussion paper considers the possibility of applying to the recycle of plutonium in thermal reactors a particular method of partial processing based on the PUREX process but named CIVEX to emphasise the differences. The CIVEX process is based primarily on the retention of short-lived fission products. The paper suggests: (1) the recycle of fission products with uranium and plutonium in thermal reactor fuel would be technically feasible; (2) it would, however, take ten years or more to develop the CIVEX process to the point where it could be launched on a commercial scale; (3) since the majority of spent fuel to be reprocessed this century will have been in storage for ten years or more, the recycling of short-lived fission products with the U-Pu would not provide an effective means of making refabrication fuel ''inaccessible'' because the radioactivity associated with the fission products would have decayed. There would therefore be no advantage in partial processing

  6. Partial gigantism

    Directory of Open Access Journals (Sweden)

    М.М. Karimova

    2017-05-01

    Full Text Available A girl with partial gigantism (the increased I and II fingers of the left foot is being examined. This condition is a rare and unresolved problem, as the definite reason of its development is not determined. Wait-and-see strategy is recommended, as well as correcting operations after closing of growth zones, and forming of data pool for generalization and development of schemes of drug and radial therapeutic methods.

  7. Alterations in pain response are partially reversed by methylphenidate (Ritalin) in adults with attention deficit hyperactivity disorder (ADHD).

    Science.gov (United States)

    Treister, Roi; Eisenberg, Elon; Demeter, Naor; Pud, Dorit

    2015-01-01

    Attention deficit hyperactivity disorder (ADHD) is characterized by dysregulation of sensory processing and neurobiology of dopamine. Although cumulative evidence suggests that dopamine is involved in pain processing, pain perception in ADHD subjects and the effect of dopamine agonists such as methylphenidate (MP, Ritalin) on it have rarely been studied. The aims of this study were to (1) psychophysically assess sensitivity to pain in ADHD subjects as compared to controls and (2) examine the effects of MP on pain response in ADHD subjects. Thirty subjects with ADHD and 30 age- and gender-matched controls participated in a preliminary trial. Pain threshold, intensity, and tolerance in response to cold pain stimulation were measured for both groups (ADHD with no treatment). In addition, the ADHD group was reassessed following a single dose of MP treatment. The ADHD subjects "without MP" in comparison with controls displayed significantly shorter cold pain threshold (2.8 ± 2.1 vs. 5.8 ± 2.5 seconds, respectively, P ADHD subjects increased significantly compared to those with no treatment (3.6 ± 2.5 seconds, P = 0.011, and 46.4 ± 53.3 seconds, P ADHD are more sensitive to pain compared with controls and that MP may exert antinociceptive properties in these subjects. Randomized, controlled trials are warranted to verify these findings. © 2013 World Institute of Pain.

  8. The Candida albicans Ddr48 protein is essential for filamentation, stress response, and confers partial antifungal drug resistance.

    Science.gov (United States)

    Dib, Leila; Hayek, Peter; Sadek, Helen; Beyrouthy, Berna; Khalaf, Roy A

    2008-06-01

    Candida albicans is a dimorphic pathogenic fungus that causes mucosal and systemic infections. C. albicans pathogenicity is attributed to its ability to exist in different morphologic states and to respond to stress by up regulating several key genes. DDR48 is a stress-associated gene involved in DNA repair and in response to antifungal drug exposure. One allele of DDR48 was knocked out by homologous recombination that inserted a marker cassette in its position. Furthermore, reintroducing DDR48 on a plasmid created a revertant strain. Strains were grown on filamentation inducing and noninducing media, subjected to an oxidative stress challenge, injected into mice to assess virulence, and assayed for antifungal susceptibility by the E-test method. DDR48 was found to be haploid insufficient and possibly essential, since only a heterozygote, but not a homozygous, null mutant was generated. The mutant was filamentation defective on all hyphal media tested including serum and corn meal agar. Discrepancies in drug resistance profiles also were present: compared with the parental strain, DDR48/ddr48 heterozygote strain was susceptible in a dose-dependent manner to itraconazole and fluconazole and susceptible to ketoconazole. The mutant also appeared to be hypersensitive to a potentially lethal hydrogen peroxide challenge. However, no reduction in virulence of the mutant was observed. The present findings provide evidence that DDR48 is essential for filamentation, stress response, and possibly viability of C. albicans, making it a prime target for antifungal drug design.

  9. Effects of partial dietary supplementation of fish meal with soymeal on the stress and apoptosis response in the digestive system of common dentex (Dentex dentex).

    Science.gov (United States)

    Antonopoulou, Efthimia; Chouri, Eleni; Feidantsis, Konstantinos; Lazou, Antigone; Chatzifotis, Stavros

    2017-12-01

    Soybean is a common alternative protein source of plant origin in aquafeeds as it has a reasonably balanced amino acid profile and is widely available. This study aimed to investigate the influence of partial substitution of fish meal with soy meal on cytoprotective pathways and apoptosis in the digestive system of common dentex ( Dentex dentex ), using the activation of Hsp70, p38 MAPK, Bcl-2 and caspase-3. The experimental approach involved feeding of common dentex with three isoprotein and isoenergetic diets that contained fish meal as a protein source (FM), partial replacement of fish meal by soy meal 25% (SM25) and 40% (SM40) for 3 months. The SM40 diet induced Hsp70 activation only in the middle part of intestine. On the other hand, both SM25 and SM40 diets diminished the phosphorylation of p38 MAPK in the anterior and the middle part of intestine, whereas only SM25 induced p38 MAPK phosphorylation in the stomach. Moreover, a decrease in the levels of caspase-3 activity was observed in the middle and posterior intestine, as well as in the stomach after feeding with SM25 diets. Furthermore, Bcl-2 levels were increased by SM40 in the anterior and by SM25 in the middle part of intestine. SM25 and SM40 diets elicited a tissue and soy concentration specific cellular and cell protective response in the different parts of the digestive tract in common dentex.

  10. Effects of CO{sub 2} laser irradiation on the wettability and human skin fibroblast cell response of magnesia partially stabilised zirconia

    Energy Technology Data Exchange (ETDEWEB)

    Hao, L.; Lawrence, J

    2003-10-15

    Human skin fibroblast cells in vitro responses on the surface of a bioinert zirconia ceramic partially stabilised with magnesia partially stabilised zirconia (MgO-PSZ) bioinert ceramic before and after CO{sub 2} laser treatment were investigated to find the interrelationship between the cell adhesion, wettability and laser parameters. Contact angle, {theta}, measurements of a set of test liquids were a clear indication that surface treatment of the MgO-PSZ with a CO{sub 2} laser brought about a reduction in {theta}, indicating that the wettability of the MgO-PSZ had been enhanced. A relationship was found between the wettability and the microstructure of the MgO-PSZ surface and laser processing parameters. It was subsequently deduced that the factors active in causing the observed modification in the wettability of the MgO-PSZ were the increases in the surface O{sub 2} content and the polar component of the surface energy, {gamma}{sub sv}{sup p}, the latter resulting from surface melting and resolidification. Moreover, the investigation into the human skin fibroblast cell response revealed that the CO{sub 2} laser treatment of the MgO-PSZ had resulted in a surface favourable for cell adhesion, as the extent of cell attachment and adhesion on the MgO-PSZ surface was enhanced depending on laser parameters. Such an improvement in cell adhesion, which could be greatly beneficial to developing enhanced bonding at the tissue and implant interface, was influenced by the surface properties of the modified MgO-PSZ, particular wettability.

  11. Metabolic impact of partial volume correction of [18F]FDG PET-CT oncological studies on the assessment of tumor response to treatment.

    Science.gov (United States)

    Stefano, A; Gallivanone, F; Messa, C; Gilardi, M C; Gastiglioni, I

    2014-12-01

    The aim of this work is to evaluate the metabolic impact of Partial Volume Correction (PVC) on the measurement of the Standard Uptake Value (SUV) from [18F]FDG PET-CT oncological studies for treatment monitoring purpose. Twenty-nine breast cancer patients with bone lesions (42 lesions in total) underwent [18F]FDG PET-CT studies after surgical resection of breast cancer primitives, and before (PET-II) chemotherapy and hormone treatment. PVC of bone lesion uptake was performed on the two [18F]FDG PET-CT studies, using a method based on Recovery Coefficients (RC) and on an automatic measurement of lesion metabolic volume. Body-weight average SUV was calculated for each lesion, with and without PVC. The accuracy, reproducibility, clinical feasibility and the metabolic impact on treatment response of the considered PVC method was evaluated. The PVC method was found clinically feasible in bone lesions, with an accuracy of 93% for lesion sphere-equivalent diameter >1 cm. Applying PVC, average SUV values increased, from 7% up to 154% considering both PET-I and PET-II studies, proving the need of the correction. As main finding, PVC modified the therapy response classification in 6 cases according to EORTC 1999 classification and in 5 cases according to PERCIST 1.0 classification. PVC has an important metabolic impact on the assessment of tumor response to treatment by [18F]FDG PET-CT oncological studies.

  12. Partial validation of a French version of the ADHD-rating scale IV on a French population of children with ADHD and epilepsy. Factorial structure, reliability, and responsiveness.

    Science.gov (United States)

    Mercier, Catherine; Roche, Sylvain; Gaillard, Ségolène; Kassai, Behrouz; Arzimanoglou, Alexis; Herbillon, Vania; Roy, Pascal; Rheims, Sylvain

    2016-05-01

    Attention deficit hyperactivity disorder (ADHD) is a well-known comorbidity in children with epilepsy. In English-speaking countries, the scores of the original ADHD-rating scale IV are currently used as main outcomes in various clinical trials in children with epilepsy. In French-speaking countries, several French versions are in use though none has been fully validated yet. We sought here for a partial validation of a French version of the ADHD-RS IV regarding construct validity, internal consistency (i.e., scale reliability), item reliability, and responsiveness in a group of French children with ADHD and epilepsy. The study involved 167 children aged 6-15years in 10 French neuropediatric units. The factorial structure and item reliability were assessed with a confirmatory factorial analysis for ordered categorical variables. The dimensions' internal consistency was assessed with Guttman's lambda 6 coefficient. The responsiveness was assessed by the change in score under methylphenidate and in comparison with a control group. The results confirmed the original two-dimensional factorial structure (inattention, hyperactivity/impulsivity) and showed a satisfactory reliability of most items, a good dimension internal consistency, and a good responsiveness of the total score and the two subscores. The studied French version of the ADHD-RS IV is thus validated regarding construct validity, reliability, and responsiveness. It can now be used in French-speaking countries in clinical trials of treatments involving children with ADHD and epilepsy. The full validation requires further investigations. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. β-Naphthoflavone enhances oxidative stress responses and the induction of preneoplastic lesions in a diethylnitrosamine-initiated hepatocarcinogenesis model in partially hepatectomized rats

    International Nuclear Information System (INIS)

    Dewa, Yasuaki; Nishimura, Jihei; Muguruma, Masako; Jin, Meilan; Saegusa, Yukie; Okamura, Toshiya; Tasaki, Masako; Umemura, Takashi; Mitsumori, Kunitoshi

    2008-01-01

    The tumour-promoting effects of β-naphthoflavone (BNF), a novel aryl hydrocarbon receptor (AhR) agonist, were investigated using a medium-term hepatocarcinogenesis model in rats. Six-week-old male F344 rats received an intraperitoneal injection of N-diethylnitrosamine (DEN) at a dose of 200 mg/kg body weight and were fed a diet containing 0% (basal diet), 0.5% or 1% BNF for 6 weeks from 2 weeks after DEN treatment. All animals were subjected to two-thirds partial hepatectomy 1 week after the BNF treatment. The number and area of glutathione S-transferase placental form (GST-P) positive foci significantly increased in the livers of rats treated with BNF with concomitantly increased cell proliferation compared to those in the livers of the DEN alone group. Global gene expression analysis and subsequent quantitative real-time reverse transcription-polymerase chain reaction revealed that BNF induced not only the 'AhR gene battery'Cyp1a1, Cyp1a2, Cyp1b1, Nqo1, Aldh3a1 and Ugt1a6 but also the transcription factor NF-E2-related factor 2 (Nrf2)-regulated genes such as Gstm1, Gpx2, Akr7a3 and Yc2 (and also Nqo1), presumably due to the adaptive response against BNF-triggered oxidative stress responses. Reactive oxygen species production increased in microsomes isolated from the livers of BNF-treated rats, and this enhancement was suppressed by the P450 inhibitor SKF-525A. Furthermore, BNF enhanced oxidative DNA damage and lipid peroxidation, estimated by the levels of 8-hydroxydeoxyguanosine (8-OHdG) and thiobarbituric acid-reactive substances. These results suggest that the administration of BNF at a high dose and over a long-term enhance oxidative stress responses which may contribute to its hepatocarcinogenic potential in rats

  14. EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors.

    Science.gov (United States)

    Prickaerts, Jos; van Goethem, Nick P; Chesworth, Richard; Shapiro, Gideon; Boess, Frank G; Methfessel, Christoph; Reneerkens, Olga A H; Flood, Dorothy G; Hilt, Dana; Gawryl, Maria; Bertrand, Sonia; Bertrand, Daniel; König, Gerhard

    2012-02-01

    EVP-6124, (R)-7-chloro-N-quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide, is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs) that was evaluated here in vitro and in vivo. In binding and functional experiments, EVP-6124 showed selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs. EVP-6124 had good brain penetration and an adequate exposure time. EVP-6124 (0.3 mg/kg, p.o.) significantly restored memory function in scopolamine-treated rats (0.1 mg/kg, i.p.) in an object recognition task (ORT). Although donepezil at 0.1 mg/kg, p.o. or EVP-6124 at 0.03 mg/kg, p.o. did not improve memory in this task, co-administration of these sub-efficacious doses fully restored memory. In a natural forgetting test, an ORT with a 24 h retention time, EVP-6124 improved memory at 0.3 mg/kg, p.o. This improvement was blocked by the selective α7 nAChR antagonist methyllycaconitine (0.3 mg/kg, i.p. or 10 μg, i.c.v.). In co-application experiments of EVP-6124 with acetylcholine, sustained exposure to EVP-6124 in functional investigations in oocytes caused desensitization at concentrations greater than 3 nM, while lower concentrations (0.3-1 nM) caused an increase in the acetylcholine-evoked response. These actions were interpreted as representing a co-agonist activity of EVP-6124 with acetylcholine on α7 nAChRs. The concentrations of EVP-6124 that resulted in physiological potentiation were consistent with the free drug concentrations in brain that improved memory performance in the ORT. These data suggest that the selective partial agonist EVP-6124 improves memory performance by potentiating the acetylcholine response of α7 nAChRs and support new therapeutic strategies for the treatment of cognitive impairment. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'. Copyright © 2011 Elsevier Ltd. All rights reserved.

  15. Orengedoku-to augmentation in cases showing partial response to yokukan-san treatment: a case report and literature review of the evidence for use of these Kampo herbal formulae

    Directory of Open Access Journals (Sweden)

    Okamoto H

    2013-01-01

    , improved the tardive dystonia by 80% in Case 2, and was completely effective in controlling the patient's aggressive impulses in Case 3.Conclusion: Together with empirical evidence demonstrating the effectiveness of both yokukan-san and orengedoku-to in reducing irritability, impulsivity, and aggression, these three cases suggest that orengedoku-to augmentation can be an effective option in cases that are partially responsive to yokukan-san treatment.Keywords: traditional medicine, aggressiveness, tardive dystonia, intermittent explosive disorder

  16. Population dose-response analysis of daily seizure count following vigabatrin therapy in adult and pediatric patients with refractory complex partial seizures.

    Science.gov (United States)

    Nielsen, Jace C; Hutmacher, Matthew M; Wesche, David L; Tolbert, Dwain; Patel, Mahlaqa; Kowalski, Kenneth G

    2015-01-01

    Vigabatrin is an irreversible inhibitor of γ-aminobutyric acid transaminase (GABA-T) and is used as an adjunctive therapy for adult patients with refractory complex partial seizures (rCPS). The purpose of this investigation was to describe the relationship between vigabatrin dosage and daily seizure rate for adults and children with rCPS and identify relevant covariates that might impact seizure frequency. This population dose-response analysis used seizure-count data from three pediatric and two adult randomized controlled studies of rCPS patients. A negative binomial distribution model adequately described daily seizure data. Mean seizure rate decreased with time after first dose and was described using an asymptotic model. Vigabatrin drug effects were best characterized by a quadratic model using normalized dosage as the exposure metric. Normalized dosage was an estimated parameter that allowed for individualized changes in vigabatrin exposure based on body weight. Baseline seizure rate increased with decreasing age, but age had no impact on vigabatrin drug effects after dosage was normalized for body weight differences. Posterior predictive checks indicated the final model was capable of simulating data consistent with observed daily seizure counts. Total normalized vigabatrin dosages of 1, 3, and 6 g/day were predicted to reduce seizure rates 23.2%, 45.6%, and 48.5%, respectively. © 2014, The American College of Clinical Pharmacology.

  17. Partial symptom-response to proton pump inhibitors in patients with non-erosive reflux disease or reflux oesophagitis - a post hoc analysis of 5796 patients

    DEFF Research Database (Denmark)

    Bytzer, P; van Zanten, S Veldhuyzen; Mattsson, H

    2012-01-01

    Although most patients with gastro-oesophageal reflux disease (GERD) benefit from proton pump inhibitor (PPI) therapy, some experience only partial symptom relief.......Although most patients with gastro-oesophageal reflux disease (GERD) benefit from proton pump inhibitor (PPI) therapy, some experience only partial symptom relief....

  18. [Effects of seawater immersion on the inflammatory response and oxygen free radical injury of rats with superficial partial-thickness scald at early stage].

    Science.gov (United States)

    Yang, Y X; Wang, J H; Liu, L; Zou, Q; Zhang, Y; Bai, Z

    2017-06-20

    Objective: To study the effects of seawater immersion on the inflammatory response and oxygen free radical injury of rats with superficial-thickness scald at early stage. Methods: Seventy Wistar rats were divided into healthy control group (HC, n =7), pure scald group (PS, n =21), scald+ fresh water immersion group (SF, n =21), and scald+ seawater immersion group (SS, n =21) according to the random number table. Rats in group HC did not receive any treatment, while 5% total body surface area superficial partial-thickness scald was made on the back of rats in the latter three groups. Rats in group PS lived freely immediately post burn, while wounds on the back of rats in groups SF and SS were immersed into fresh water and seawater, respectively. Serum and full-thickness skin tissue in the center of wounds on the back of 7 rats in groups PS, SF, and SS at post immersion (injury) hour (PIH) 2, 4, and 6 were collected, respectively, while serum and full-thickness skin tissue at the same position of the 7 rats in group HC were collected at PIH 6 of rats in other groups. Morphology of skin tissue was observed with HE staining; tumor necrosis factor-alpha (TNF-α) content in serum and skin tissue was determined by enzyme-linked immunosorbent assay; superoxide dismutase (SOD) content in serum and skin tissue was determined by hydroxylamine method; malondialdehyde content in serum and skin tissue was determined by thiobarbituric acid method. Data were processed with analysis of variance of factorial design, one-way analysis of variance, Welch test, LSD test, and Tamhane test. Results: (1) Epidermal cells of skin tissue of rats in group HC arranged in order and continuously, and the dermis tissue and accessory structures were clear and complete. The skin layer and epidermis of wounds of rats in group PS had no significant change, but the edema of epidermis and dermis and infiltration of inflammatory cells enhanced over time at PIH 2, 4, and 6. The horny layer of epidermis of

  19. Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.

    Science.gov (United States)

    Eggler, Aimee L; Small, Evan; Hannink, Mark; Mesecar, Andrew D

    2009-07-29

    Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that activates transcription of a battery of cytoprotective genes by binding to the ARE (antioxidant response element). Nrf2 is repressed by the cysteine-rich Keap1 (kelch-like ECH-associated protein 1) protein, which targets Nrf2 for ubiquitination and subsequent degradation by a Cul3 (cullin 3)-mediated ubiquitination complex. We find that modification of Cys(151) of human Keap1, by mutation to a tryptophan, relieves the repression by Keap1 and allows activation of the ARE by Nrf2. The Keap1 C151W substitution has a decreased affinity for Cul3, and can no longer serve to target Nrf2 for ubiquitination, though it retains its affinity for Nrf2. A series of 12 mutant Keap1 proteins, each containing a different residue at position 151, was constructed to explore the chemistry required for this effect. The series reveals that the extent to which Keap1 loses the ability to target Nrf2 for degradation, and hence the ability to repress ARE activation, correlates well with the partial molar volume of the residue. Other physico-chemical properties do not appear to contribute significantly to the effect. Based on this finding, a structural model is proposed whereby large residues at position 151 cause steric clashes that lead to alteration of the Keap1-Cul3 interaction. This model has significant implications for how electrophiles which modify Cys(151), disrupt the repressive function of Keap1.

  20. Performance Comparison of 112-Gb/s DMT, Nyquist PAM4, and Partial-Response PAM4 for Future 5G Ethernet-Based Fronthaul Architecture

    Science.gov (United States)

    Eiselt, Nicklas; Muench, Daniel; Dochhan, Annika; Griesser, Helmut; Eiselt, Michael; Olmos, Juan Jose Vegas; Monroy, Idelfonso Tafur; Elbers, Joerg-Peter

    2018-05-01

    For a future 5G Ethernet-based fronthaul architecture, 100G trunk lines of a transmission distance up to 10 km standard single mode fiber (SSMF) in combination with cheap grey optics to daisy chain cell site network interfaces are a promising cost- and power-efficient solution. For such a scenario, different intensity modulation and direct detect (IMDD) Formats at a data rate of 112 Gb/s, namely Nyquist four-level pulse amplitude modulation (PAM4), discrete multi-tone Transmission (DMT) and partial-response (PR) PAM4 are experimentally investigated, using a low-cost electro-absorption modulated laser (EML), a 25G driver and current state-of-the-art high Speed 84 GS/s CMOS digital-to-analog converter (DAC) and analog-to-digital converter (ADC) test chips. Each modulation Format is optimized independently for the desired scenario and their digital signal processing (DSP) requirements are investigated. The performance of Nyquist PAM4 and PR PAM4 depend very much on the efficiency of pre- and post-equalization. We show the necessity for at least 11 FFE-taps for pre-emphasis and up to 41 FFE coefficients at the receiver side. In addition, PR PAM4 requires an MLSE with four states to decode the signal back to a PAM4 signal. On the contrary, bit- and power-loading (BL, PL) is crucial for DMT and an FFT length of at least 512 is necessary. With optimized parameters, all Modulation formats result in a very similar performances, demonstrating a transmission distance of up to 10 km over SSMF with bit error rates (BERs) below a FEC threshold of 4.4E-3, allowing error free transmission.

  1. Comparative efficacy of tadalafil once daily in men with erectile dysfunction who demonstrated previous partial responses to as-needed sildenafil, tadalafil, or vardenafil.

    Science.gov (United States)

    Kim, Edward; Seftel, Allen; Goldfischer, Evan; Baygani, Simin; Burns, Patrick

    2015-02-01

    Phosphodiesterase type-5 inhibitors (PDE5Is) are first-line therapies for erectile dysfunction (ED). Sildenafil (SIL) and vardenafil (VAR) are approved for as-needed (PRN) dosing; tadalafil (TAD) is approved for both PRN and once-a-day (OaD) dosing for ED. Recent evidence suggests that TAD-OaD may be effective as therapy in men with an incomplete response to PRN-PDE5I therapy. This study evaluated whether TAD-OaD provides similar efficacy in men with ED who had previously demonstrated a partial response to PRN-PDE5I therapy. In this randomized, double-blind, placebo-controlled trial, men with a ≥3 month ED history received SIL 100 mg, TAD 20 mg, or VAR 20 mg during a 4 week open-label lead-in period. Those with International Index of Erectile Function - Erectile Function (IIEF-EF) domain scores TAD 2.5 mg up-titrated to 5 mg, TAD 5 mg, or placebo (PBO) OaD for 12 weeks. MAIN OUTCOME MEASURES obtained from patients treated with TAD-OaD were compared to PBO-treated patients. Additionally, results of treatment with TAD-OaD were compared to results obtained from 4 week PRN-PDE5I therapy to determine whether OaD and PRN regimens provided comparable efficacy. NCT01130532. International Index of Erectile Function (IIEF) domain scores; Sexual Encounter Profile (SEP) questions 2-5. Endpoint data was obtained from 590 men (391 TAD; 199 PBO). RESULTS for all IIEF and SEP measures were significantly better for TAD-OaD (p TAD 2.5 mg and TAD 5 mg OaD therapy were safe and generally well tolerated. Tadalafil once daily is a viable alternative to as-needed PDE5I therapy in men with ED. Key limitations include the lack of a PRN PDE5I study group during the double-blind period, and that many more patients took tadalafil than sildenafil or vardenafil during the PRN period.

  2. Arthroscopic partial medial meniscectomy

    Directory of Open Access Journals (Sweden)

    Dašić Žarko

    2011-01-01

    Full Text Available Background/Aim. Meniscal injuries are common in professional or recreational sports as well as in daily activities. If meniscal lesions lead to physical impairment they usually require surgical treatment. Arthroscopic treatment of meniscal injuries is one of the most often performed orthopedic operative procedures. Methods. The study analyzed the results of arthroscopic partial medial meniscectomy in 213 patients in a 24-month period, from 2006, to 2008. Results. In our series of arthroscopically treated medial meniscus tears we noted 78 (36.62% vertical complete bucket handle lesions, 19 (8.92% vertical incomplete lesions, 18 (8.45% longitudinal tears, 35 (16.43% oblique tears, 18 (8.45% complex degenerative lesions, 17 (7.98% radial lesions and 28 (13.14% horisontal lesions. Mean preoperative International Knee Documentation Committee (IKDC score was 49.81%, 1 month after the arthroscopic partial medial meniscectomy the mean IKDC score was 84.08%, and 6 months after mean IKDC score was 90.36%. Six months after the procedure 197 (92.49% of patients had good or excellent subjective postoperative clinical outcomes, while 14 (6.57% patients subjectively did not notice a significant improvement after the intervention, and 2 (0.93% patients had no subjective improvement after the partial medial meniscectomy at all. Conclusion. Arthroscopic partial medial meniscetomy is minimally invasive diagnostic and therapeutic procedure and in well selected cases is a method of choice for treatment of medial meniscus injuries when repair techniques are not a viable option. It has small rate of complications, low morbidity and fast rehabilitation.

  3. [Predictive value of central venous-to-arterial carbon dioxide partial pressure difference for fluid responsiveness in septic shock patients: a prospective clinical study].

    Science.gov (United States)

    Liu, Guangyun; Huang, Huibin; Qin, Hanyu; Du, Bin

    2018-05-01

    To evaluate the accuracy of central venous-to-arterial carbon dioxide partial pressure difference (Pcv-aCO 2 ) before and after rapid rehydration test (fluid challenge) in predicting the fluid responsiveness in patients with septic shock. A prospective observation was conducted. Forty septic shock patients admitted to medical intensive care unit (ICU) of Peking Union Medical College Hospital from October 2015 to June 2017 were enrolled. All of the patients received fluid challenge in the presence of invasive hemodynamic monitoring. Heart rate (HR), blood pressure, cardiac index (CI), Pcv-aCO 2 and other physiological variables were recorded at 10 minutes before and immediately after fluid challenge. Fluid responsiveness was defined as an increase in CI greater than 10% after fluid challenge, whereas fluid non-responsiveness was defined as no increase or increase in CI less than 10%. The correlation between Pcv-aCO 2 and CI was explored by Pearson correlation analysis. Receiver operating characteristic (ROC) curves were established to evaluate the discriminatory abilities of baseline and the changes after fluid challenge in Pcv-aCO 2 and other physiological variables to define the fluid responsiveness. The patients were separated into two groups according to the initial value of Pcv-aCO 2 . The cut-off value of 6 mmHg (1 mmHg = 0.133 kPa) was chosen according to previous studies. The discriminatory abilities of baseline and the change in Pcv-aCO 2 (ΔPcv-aCO 2 ) were assessed in each group. A total of 40 patients were finally included in this study. Twenty-two patients responded to the fluid challenge (responders). Eighteen patients were fluid non-responders. There was no significant difference in baseline physiological variable between the two groups. Fluid challenge could increase CI and blood pressure significantly, decrease HR notably and had no effect on Pcv-aCO 2 in fluid responders. In non-responders, blood pressure was increased significantly and CI, HR, Pcv

  4. Photogenic partial seizures.

    Science.gov (United States)

    Hennessy, M J; Binnie, C D

    2000-01-01

    To establish the incidence and symptoms of partial seizures in a cohort of patients investigated on account of known sensitivity to intermittent photic stimulation and/or precipitation of seizures by environmental visual stimuli such as television (TV) screens or computer monitors. We report 43 consecutive patients with epilepsy, who had exhibited a significant EEG photoparoxysmal response or who had seizures precipitated by environmental visual stimuli and underwent detailed assessment of their photosensitivity in the EEG laboratory, during which all were questioned concerning their ictal symptoms. All patients were considered on clinical grounds to have an idiopathic epilepsy syndrome. Twenty-eight (65%) patients reported visually precipitated attacks occurring initially with maintained consciousness, in some instances evolving to a period of confusion or to a secondarily generalized seizure. Visual symptoms were most commonly reported and included positive symptoms such as coloured circles or spots, but also blindness and subjective symptoms such as "eyes going funny." Other symptoms described included nonspecific cephalic sensations, deja-vu, auditory hallucinations, nausea, and vomiting. No patient reported any clear spontaneous partial seizures, and there were no grounds for supposing that any had partial epilepsy excepting the ictal phenomenology of some or all of the visually induced attacks. These findings provide clinical support for the physiological studies that indicate that the trigger mechanism for human photosensitivity involves binocularly innervated cells located in the visual cortex. Thus the visual cortex is the seat of the primary epileptogenic process, and the photically triggered discharges and seizures may be regarded as partial with secondary generalization.

  5. Summary of the discussion, Conclusion of the meeting

    International Nuclear Information System (INIS)

    Crutzen, S.

    1997-01-01

    The discussion was organised in three major periods corresponding to the main themes developed by the programme of the meeting: the qualification approaches, the qualification experience accumulated so far, one particular frame or motivation of the ISI qualification: the risk based (or informed) ISI. The qualification approaches presented by national representatives raised few questions. More discussion was induced on the qualification concepts, responsibilities, need and writing of the technical justification, motivation for the open trials, similitude between concepts, benefit deriving from the qualification of inspection procedures and further motivation. the conclusion could be as the following: the evolution of qualification applications, even if issued from harmonised concepts, appears to be nationalistically based. It is a thought that emulation and harmonisation could actually produce both savings and improvements in this area. 'The wheel does not have to be re-invented in each country' and it is the declared objective of ENIQ. There seems to be a need for some international agreement in the setting of standards for qualification. One area which seems to continue to be of underlying concern is in the characterisation of defects. There seems to be a need for appropriate 'defected blocks' satisfying the criteria of representativeness, quality, low cost, reproducibility, etc. More specific cases of Technical Justification development are needed to serve as examples and incentive for the case of this element of inspection qualification

  6. A comprehensive study on partial shading response of c-Si modules and yield modeling of string inverter and module level power electronics

    NARCIS (Netherlands)

    Sinapis, K.; Tzikas, C.; Litjens, G.; van den Donker, M.; Folkerts, W.; van Sark, W.G.J.H.M.; Smets, A.

    2016-01-01

    Building Integrated and Building Attached Photovoltaic (BIPV, BAPV) systems may suffer from lower performance than predicted as a result of not considered partial shading. New system architectures have been proposed to optimize performance. The common approach of these new architectures is to track

  7. Multiwavelength Lidar Observation of the Atmospheric Response to the 20th March 2015 Partial Solar Eclipse in Rome Tor Vergata: Preliminary Results.

    Directory of Open Access Journals (Sweden)

    Liberti Gian Luigi

    2016-01-01

    Full Text Available This study reports some preliminary analyses of multichannel lidar measurements taken in Rome Tor Vergata (Italy during the 20th March 2015 partial solar eclipse. The objective is assessing the capability of the instrument to document the effect of the eclipse in the lower troposphere, with a particular emphasis on the information content at relatively small temporal and spatial scales.

  8. Multiwavelength Lidar Observation of the Atmospheric Response to the 20th March 2015 Partial Solar Eclipse in Rome Tor Vergata: Preliminary Results.

    Science.gov (United States)

    Liberti, Gian Luigi; Dionisi, Davide; Federico, Stefano; Congeduti, Fernando

    2016-06-01

    This study reports some preliminary analyses of multichannel lidar measurements taken in Rome Tor Vergata (Italy) during the 20th March 2015 partial solar eclipse. The objective is assessing the capability of the instrument to document the effect of the eclipse in the lower troposphere, with a particular emphasis on the information content at relatively small temporal and spatial scales.

  9. Can repeat injection provide clinical benefit in patients with cervical disc herniation and stenosis when the first epidural injection results only in partial response?

    Science.gov (United States)

    Lee, Jung Hwan; Lee, Sang-Ho

    2016-07-01

    Epidural steroid injection (ESI) is known to be an effective treatment for neck or radicular pain due to herniated intervertebral disc (HIVD) and spinal stenosis (SS). Although repeat ESI has generally been indicated to provide more pain relief in partial responders after single ESI, there has been little evidence supporting the usefulness of this procedure. The purpose of this study, therefore, was to determine whether repeat ESI at a prescribed interval of 2 to 3 weeks after the first injection would provide greater clinical benefit in patients with partial pain reduction than intermittent ESI performed only when pain was aggravated. One hundred eighty-four patients who underwent transforaminal ESI (TFESI) for treatment of axial neck and radicular arm pain due to HIVD or SS and could be followed up for 1 year were enrolled. We divided the patients into 2 groups. Group A (N = 108) comprised partial responders (numeric rating scale (NRS) ≥ 3 after the first injection) who underwent repeat injection at a prescribed interval of 2 to 3 weeks after the first injection. Group B (N = 76) comprised partial responders who did not receive repeat injection at the prescribed interval, but received intermittent injections only for aggravation of pain. Various clinical data were assessed, including total number of injections during 1 year, NRS duration of Group A, or after first injection in Group B (time to reinjection). Groups A and B were compared in terms of total population, HIVD, and SS. In the whole population, HIVD subgroup, and SS subgroup, patients in Group A required significantly fewer injections to obtain satisfactory pain relief during the 1-year follow-up period. Group A showed a significantly longer time to reinjection and longer NRS Group B did. Repeat TFESI conducted at 2- to 3-week intervals after the first injection in partial responders contributed to greater clinical benefit compared with intermittent TFESI performed only upon pain

  10. Parachute technique for partial penectomy

    Directory of Open Access Journals (Sweden)

    Fernando Korkes

    2010-04-01

    Full Text Available PURPOSE: Penile carcinoma is a rare but mutilating malignancy. In this context, partial penectomy is the most commonly applied approach for best oncological results. We herein propose a simple modification of the classic technique of partial penectomy, for better cosmetic and functional results. TECHNIQUE: If partial penectomy is indicated, the present technique can bring additional benefits. Different from classical technique, the urethra is spatulated only ventrally. An inverted "V" skin flap with 0.5 cm of extension is sectioned ventrally. The suture is performed with vicryl 4-0 in a "parachute" fashion, beginning from the ventral portion of the urethra and the "V" flap, followed by the "V" flap angles and than by the dorsal portion of the penis. After completion of the suture, a Foley catheter and light dressing are placed for 24 hours. CONCLUSIONS: Several complex reconstructive techniques have been previously proposed, but normally require specific surgical abilities, adequate patient selection and staged procedures. We believe that these reconstructive techniques are very useful in some specific subsets of patients. However, the technique herein proposed is a simple alternative that can be applied to all men after a partial penectomy, and takes the same amount of time as that in the classic technique. In conclusion, the "parachute" technique for penile reconstruction after partial amputation not only improves the appearance of the penis, but also maintains an adequate function.

  11. Metabolic and enzymatic changes associated with carbon mobilization, utilization and replenishment triggered in grain amaranth (Amaranthus cruentus in response to partial defoliation by mechanical injury or insect herbivory

    Directory of Open Access Journals (Sweden)

    Castrillón-Arbeláez Paula

    2012-09-01

    Full Text Available Abstract Background Amaranthus cruentus and A. hypochondriacus are crop plants grown for grain production in subtropical countries. Recently, the generation of large-scale transcriptomic data opened the possibility to study representative genes of primary metabolism to gain a better understanding of the biochemical mechanisms underlying tolerance to defoliation in these species. A multi-level approach was followed involving gene expression analysis, enzyme activity and metabolite measurements. Results Defoliation by insect herbivory (HD or mechanical damage (MD led to a rapid and transient reduction of non-structural carbohydrates (NSC in all tissues examined. This correlated with a short-term induction of foliar sucrolytic activity, differential gene expression of a vacuolar invertase and its inhibitor, and induction of a sucrose transporter gene. Leaf starch in defoliated plants correlated negatively with amylolytic activity and expression of a β-amylase-1 gene and positively with a soluble starch synthase gene. Fatty-acid accumulation in roots coincided with a high expression of a phosphoenolpyruvate/phosphate transporter gene. In all tissues there was a long-term replenishment of most metabolite pools, which allowed damaged plants to maintain unaltered growth and grain yield. Promoter analysis of ADP-glucose pyrophosphorylase and vacuolar invertase genes indicated the presence of cis-regulatory elements that supported their responsiveness to defoliation. HD and MD had differential effects on transcripts, enzyme activities and metabolites. However, the correlation between transcript abundance and enzymatic activities was very limited. A better correlation was found between enzymes, metabolite levels and growth and reproductive parameters. Conclusions It is concluded that a rapid reduction of NSC reserves in leaves, stems and roots followed by their long-term recovery underlies tolerance to defoliation in grain amaranth. This requires the

  12. Number of objectives and conclusions in dissertations and thesis

    Directory of Open Access Journals (Sweden)

    Liebano Richard Eloin

    2005-01-01

    Full Text Available PURPOSE: To analyze the number of objectives and conclusions presented in dissertations and thesis defended at Federal University of São Paulo - Paulista School of Medicine (UNIFESP - EPM. METHODS: It was realized a search in the master degree dissertations and doctor degree thesis defended at Federal University of São Paulo - Paulista School of Medicine in the years 2002 and 2003 that were found available in the central library of this university. RESULTS: From 723 master dissertations analyzed, 62 (8,57% presented only one objective and one conclusion, 134 (18,53% presented one objective and more than one conclusion and 527 (72,89% had more than one objective and more than one conclusion. From 502 doctor thesis analyzed, 23 (4,58% presented only one objective and one conclusion, 123 (24,50% presented one objective and more than one conclusion and 376 (74,90% had more than one objective and more than one conclusion.. CONCLUSIONS: It wasn't found in researched literature the number of objectives and conclusions a scientific work must have. A highest number of thesis and dissertations presented more than one objective and more than one conclusion.

  13. Visual Enhancement of Laparoscopic Partial Nephrectomy With 3-Charge Coupled Device Camera: Assessing Intraoperative Tissue Perfusion and Vascular Anatomy by Visible Hemoglobin Spectral Response

    Science.gov (United States)

    2010-10-01

    reliably distinguish vascular structures during hilar dissection, and detect and monitor changes in renal tissue perfus:ion dw·ing and after warm...and in 25 patients with hilar tu- mors 16 in whom perioperative outcomes were com- parable to those of peripheral tumors. In a retro- spective study...Richstone et al also reported the safe performance of LPN for hilar tumors in 17 patients.17 Repeat partial nephrectomy for ipsilat- eral tumor has

  14. A Review and Comparison of Mouse and Rat Responses to Micro Gravity, Hyper Gravity and Simulated Models of Partial Gravity; Species Differences, Gaps in the Available Data, and Consideration of the Advantages and Caveats of Each Model for Spaceflight

    Science.gov (United States)

    Donovan, F. M.; Gresser, A. L.; Sato, Kevin Y.; Taylor, Elizabeth M.

    2018-01-01

    Laboratory strains of mice and rat are widely used to study mammalian responses to stimulus, and both have been studied under a variety of gravity conditions, including space flight. We compared results obtained from exposure to spaceflight and microgravity, hyper gravity via centrifugation, earth gravity, and models of simulated partial gravity (hind-limb unloading and partial weight bearing treatments). We examined the reported changes in survival, body mass, circadian rhythm (body temperature and activity levels), behavior, bone, muscle, immune, cardio-vasculature, vestibular, reproduction and neonate survival, microbiome, and the visual system. Not all categories have published data for both species, some have limited data, and there are variations in experiment design that allow for only relative comparisons to be considered. The data reveal species differences in both the level of gravity required to obtain a response, degree of response, and in temporal expression of responses. Examination of the data across the gravity levels allows consideration of the hypothesis that gravitational responses follow a continuum, and organ specific differences are noted. In summary, we present advantages and caveats of each model system as pertains to gravitational biology research and identify gaps in our knowledge of how these mammals respond to gravity.

  15. Study design does not always allow a simple conclusion

    DEFF Research Database (Denmark)

    Roos, Ewa M.; Thorlund, Jonas Bloch; Juhl, Carsten Bogh

    2014-01-01

    Response to Arthroscopic surgery for degenerative tears of the meniscus: a systematic review and meta-analysis......Response to Arthroscopic surgery for degenerative tears of the meniscus: a systematic review and meta-analysis...

  16. Implementation of severe accident management measures - Summary and conclusions

    International Nuclear Information System (INIS)

    2002-01-01

    implemented in various ways in many plants, but not yet in all plants. A systematic approach, which is based upon a clearly defined decision-making process, is one of the features implemented in many cases. Available means are determined and priorities are set. This approach is made up of strategies intended to become an optimum approach to prevent or mitigate the consequences of beyond-design basis accidents. It is based upon a prepared information package about plant-specific behaviour to be expected in beyond design scenarios. The approaches followed in the different countries do not fit one single pattern. Harmonization, to the extent it is desirable, does not seem feasible at this stage. As a rule, the responsibility of the plant owner for the safety of his plant remains untouched. Also, safety goals may vary between countries. This report presents the general conclusion and recommendations of the workshop and the summaries of the sessions

  17. Partial tooth gear bearings

    Science.gov (United States)

    Vranish, John M. (Inventor)

    2010-01-01

    A partial gear bearing including an upper half, comprising peak partial teeth, and a lower, or bottom, half, comprising valley partial teeth. The upper half also has an integrated roller section between each of the peak partial teeth with a radius equal to the gear pitch radius of the radially outwardly extending peak partial teeth. Conversely, the lower half has an integrated roller section between each of the valley half teeth with a radius also equal to the gear pitch radius of the peak partial teeth. The valley partial teeth extend radially inwardly from its roller section. The peak and valley partial teeth are exactly out of phase with each other, as are the roller sections of the upper and lower halves. Essentially, the end roller bearing of the typical gear bearing has been integrated into the normal gear tooth pattern.

  18. Essays on partial retirement

    NARCIS (Netherlands)

    Kantarci, T.

    2012-01-01

    The five essays in this dissertation address a range of topics in the micro-economic literature on partial retirement. The focus is on the labor market behavior of older age groups. The essays examine the economic and non-economic determinants of partial retirement behavior, the effect of partial

  19. Diffusion versus linear ballistic accumulation: different models but the same conclusions about psychological processes?

    NARCIS (Netherlands)

    Donkin, C.; Brown, S.; Heathcote, A.; Wagenmakers, E.-J.

    2011-01-01

    Quantitative models for response time and accuracy are increasingly used as tools to draw conclusions about psychological processes. Here we investigate the extent to which these substantive conclusions depend on whether researchers use the Ratcliff diffusion model or the Linear Ballistic

  20. Mirror neuron activation as a function of explicit learning: changes in mu-event-related power after learning novel responses to ideomotor compatible, partially compatible, and non-compatible stimuli.

    Science.gov (United States)

    Behmer, Lawrence P; Fournier, Lisa R

    2016-11-01

    Questions regarding the malleability of the mirror neuron system (MNS) continue to be debated. MNS activation has been reported when people observe another person performing biological goal-directed behaviors, such as grasping a cup. These findings support the importance of mapping goal-directed biological behavior onto one's motor repertoire as a means of understanding the actions of others. Still, other evidence supports the Associative Sequence Learning (ASL) model which predicts that the MNS responds to a variety of stimuli after sensorimotor learning, not simply biological behavior. MNS activity develops as a consequence of developing stimulus-response associations between a stimulus and its motor outcome. Findings from the ideomotor literature indicate that stimuli that are more ideomotor compatible with a response are accompanied by an increase in response activation compared to less compatible stimuli; however, non-compatible stimuli robustly activate a constituent response after sensorimotor learning. Here, we measured changes in the mu-rhythm, an EEG marker thought to index MNS activity, predicting that stimuli that differ along dimensions of ideomotor compatibility should show changes in mirror neuron activation as participants learn the respective stimulus-response associations. We observed robust mu-suppression for ideomotor-compatible hand actions and partially compatible dot animations prior to learning; however, compatible stimuli showed greater mu-suppression than partially or non-compatible stimuli after explicit learning. Additionally, non-compatible abstract stimuli exceeded baseline only after participants explicitly learned the motor responses associated with the stimuli. We conclude that the empirical differences between the biological and ASL accounts of the MNS can be explained by Ideomotor Theory. © 2016 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

  1. Landsliding in partially saturated materials

    Science.gov (United States)

    Godt, J.W.; Baum, R.L.; Lu, N.

    2009-01-01

    [1] Rainfall-induced landslides are pervasive in hillslope environments around the world and among the most costly and deadly natural hazards. However, capturing their occurrence with scientific instrumentation in a natural setting is extremely rare. The prevailing thinking on landslide initiation, particularly for those landslides that occur under intense precipitation, is that the failure surface is saturated and has positive pore-water pressures acting on it. Most analytic methods used for landslide hazard assessment are based on the above perception and assume that the failure surface is located beneath a water table. By monitoring the pore water and soil suction response to rainfall, we observed shallow landslide occurrence under partially saturated conditions for the first time in a natural setting. We show that the partially saturated shallow landslide at this site is predictable using measured soil suction and water content and a novel unified effective stress concept for partially saturated earth materials. Copyright 2009 by the American Geophysical Union.

  2. Recurrent Partial Words

    Directory of Open Access Journals (Sweden)

    Francine Blanchet-Sadri

    2011-08-01

    Full Text Available Partial words are sequences over a finite alphabet that may contain wildcard symbols, called holes, which match or are compatible with all letters; partial words without holes are said to be full words (or simply words. Given an infinite partial word w, the number of distinct full words over the alphabet that are compatible with factors of w of length n, called subwords of w, refers to a measure of complexity of infinite partial words so-called subword complexity. This measure is of particular interest because we can construct partial words with subword complexities not achievable by full words. In this paper, we consider the notion of recurrence over infinite partial words, that is, we study whether all of the finite subwords of a given infinite partial word appear infinitely often, and we establish connections between subword complexity and recurrence in this more general framework.

  3. Hypothesis, Prediction, and Conclusion: Using Nature of Science Terminology Correctly

    Science.gov (United States)

    Eastwell, Peter

    2012-01-01

    This paper defines the terms "hypothesis," "prediction," and "conclusion" and shows how to use the terms correctly in scientific investigations in both the school and science education research contexts. The scientific method, or hypothetico-deductive (HD) approach, is described and it is argued that an understanding of the scientific method,…

  4. Conclusion Chapters in Doctoral Theses: Some International Findings

    Science.gov (United States)

    Trafford, Vernon; Leshem, Shosh; Bitzer, Eli

    2014-01-01

    This study investigated how candidates claimed to have made an original contribution to knowledge in the conclusion chapters of 100 PhD theses. Documentary analysis was used to discover how this was explained within theses at selected universities in three countries. No other documents were accessed and neither were candidates, supervisors or…

  5. Overview of human health in the Arctic: conclusions and recommendations.

    Science.gov (United States)

    Donaldson, Shawn; Adlard, Bryan; Odland, Jon Øyvind

    2016-01-01

    This article is intended to provide an overview of the key conclusions, knowledge gaps and key recommendations based on the recent 2015 Arctic human health assessment under the Arctic Monitoring and Assessment Program. This assessment was based primarily on data from human health monitoring and research studies and peer-reviewed literature published since the last assessment in 2009.

  6. 20 CFR 901.48 - Proposed findings and conclusions.

    Science.gov (United States)

    2010-04-01

    ... Law Judge, before making his/her decision, shall give the parties a reasonable opportunity to submit... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Proposed findings and conclusions. 901.48 Section 901.48 Employees' Benefits JOINT BOARD FOR THE ENROLLMENT OF ACTUARIES REGULATIONS GOVERNING THE...

  7. Actual Problems of Conclusion and Discharge of Urgent Labour Contracts

    Directory of Open Access Journals (Sweden)

    Shevelyova A. A.

    2013-05-01

    Full Text Available This article is devoted to the consideration of the questions connected with the conclusion and the termination of the urgent labour contract. The author, analyzing judicial practice, allocates the problems of separate regulation of the RF labour legislation enforcement.

  8. Thalidomide in induction treatment increases the very good partial response rate before and after high-dose therapy in previously untreated multiple myeloma.

    NARCIS (Netherlands)

    Lokhorst, H.M.; Schmidt-Wolf, I.; Sonneveld, P.; Holt, B. van der; Martin, H.; Barge, R.; Bertsch, U.; Schlenzka, J.; Bos, G.M.; Croockewit, S.; Zweegman, S.; Breitkreutz, I.; Joosten, P.; Scheid, C.; Marwijk-Kooy, M. van; Salwender, H.J.; Oers, M.H. van; Schaafsma, R.; Naumann, R.; Sinnige, H.A.M.; Blau, I.; Delforge, M.; Weerdt, O. de; Wijermans, P.W.; Wittebol, S.; Duersen, U.; Vellenga, E.; Goldschmidt, H.

    2008-01-01

    In the prospective phase 3 HOVON-50/GMMG-HD3 trial, patients randomized to TAD (thalidomide, doxorubicin, dexamethasone) had a significantly higher response rate (at least PR) after induction compared with patients randomized to VAD (vincristine, adriamycin, dexamethasone, 72% vs. 54%, p<0.001).

  9. Conclusion: imaging in strategy of endocrine diagnosis and therapeutics

    International Nuclear Information System (INIS)

    Mornex, R.

    1995-01-01

    Images in medicine have to help the doctor in a diagnostic or therapeutic aim. The choice must be made in function of pathology or organ as known (it is not necessary to ask for a computed tomography where we know that only an echography can give the answer to the question we ask ), the criteria must stay the best performance for the cheapest price, but the quality of interpretation is a more important thing. It is important to avoid a lot of examinations which do not give better informations but are heavy to endure for the patients. In conclusion, the aim of this kind of proceedings is to assure to the patients who come confidently to us, the best service at the less constraints price without forgetting that a conclusion depends on a given methodological situation and reminding of beside machines we have not to forget the men

  10. Conclusive identification of quantum channels via monogamy of quantum correlations

    International Nuclear Information System (INIS)

    Kumar, Asutosh; Singha Roy, Sudipto; Pal, Amit Kumar; Prabhu, R.; Sen, Aditi; Sen, Ujjwal

    2016-01-01

    We investigate the action of global noise and local channels, namely, amplitude-damping, phase-damping, and depolarizing channels, on monogamy of quantum correlations, such as negativity and quantum discord, in three-qubit systems. We discuss the monotonic and non-monotonic variation, and robustness of the monogamy scores. By using monogamy scores, we propose a two-step protocol to conclusively identify the noise applied to the quantum system, by using generalized Greenberger–Horne–Zeilinger and generalized W states as resource states. We discuss a possible generalization of the results to higher number of parties. - Highlights: • Monogamy score monotonically decays with noise for generalized GHZ state as input. • Non-monotonically decaying monogamy score with noise for generalized W state as input. • Characterizing the dynamics of monogamy score. • Dynamics terminal quantifying robustness of monogamy score against noise. • Conclusively identifying the type of noise using monogamy score.

  11. Conclusive identification of quantum channels via monogamy of quantum correlations

    Energy Technology Data Exchange (ETDEWEB)

    Kumar, Asutosh; Singha Roy, Sudipto; Pal, Amit Kumar [Harish-Chandra Research Institute, Chhatnag Road, Jhunsi, Allahabad 211019 (India); Homi Bhaba National Institute, Training School Complex, Anushaktinagar, Mumbai 400094 (India); Prabhu, R. [Harish-Chandra Research Institute, Chhatnag Road, Jhunsi, Allahabad 211019 (India); Homi Bhaba National Institute, Training School Complex, Anushaktinagar, Mumbai 400094 (India); Department of Physics, Indian Institute of Technology Patna, Bihta 801103, Bihar (India); Sen, Aditi, E-mail: aditi@hri.res.in [Harish-Chandra Research Institute, Chhatnag Road, Jhunsi, Allahabad 211019 (India); Homi Bhaba National Institute, Training School Complex, Anushaktinagar, Mumbai 400094 (India); Sen, Ujjwal [Harish-Chandra Research Institute, Chhatnag Road, Jhunsi, Allahabad 211019 (India); Homi Bhaba National Institute, Training School Complex, Anushaktinagar, Mumbai 400094 (India)

    2016-10-23

    We investigate the action of global noise and local channels, namely, amplitude-damping, phase-damping, and depolarizing channels, on monogamy of quantum correlations, such as negativity and quantum discord, in three-qubit systems. We discuss the monotonic and non-monotonic variation, and robustness of the monogamy scores. By using monogamy scores, we propose a two-step protocol to conclusively identify the noise applied to the quantum system, by using generalized Greenberger–Horne–Zeilinger and generalized W states as resource states. We discuss a possible generalization of the results to higher number of parties. - Highlights: • Monogamy score monotonically decays with noise for generalized GHZ state as input. • Non-monotonically decaying monogamy score with noise for generalized W state as input. • Characterizing the dynamics of monogamy score. • Dynamics terminal quantifying robustness of monogamy score against noise. • Conclusively identifying the type of noise using monogamy score.

  12. Biogeochemistry of uranium mill wastes program overview and conclusions

    International Nuclear Information System (INIS)

    Dreesen, D.R.

    1981-05-01

    The major findings and conclusions are summarized for research on uranium mill tailings for the US Department of Energy and the US Nuclear Regulatory Commission. An overview of results and interpretations is presented for investigations of 222 Rn emissions, revegetation of tailings and mine spoils, and trace element enrichment, mobility, and bioavailability. A brief discussion addresses the implications of these findings in relation to tailings disposal technology and proposed uranium recovery processes

  13. Summary and Conclusions. Final chapter of Scholarly Communication for Librarians.

    OpenAIRE

    Morrison, Heather

    2008-01-01

    Summary and Conclusions of Scholarly Communication for Librarians, a book designed to provide librarians at all levels with the basics of how scholarly communication works, an understanding of the academic library as an essential support for scholarly communication, the impact of the decisions librarians make, and emerging roles for libraries and librarians in scholarly communication. Includes major points from all chapters, on: scholarship, scholarly journals, the scholarly publishing indus...

  14. Review conclusions by Ernst and Canter regarding spinal manipulation refuted

    Directory of Open Access Journals (Sweden)

    Evans Roni

    2006-08-01

    Full Text Available Abstract In the April 2006 issue of the Journal of Royal Society of Medicine, Ernst and Canter authored a review of the most recent systematic reviews on the effectiveness of spinal manipulation for any condition. The authors concluded that, except for back pain, spinal manipulation is not an effective intervention for any condition and, because of potential side effects, cannot be recommended for use at all in clinical practice. Based on a critical appraisal of their review, the authors of this commentary seriously challenge the conclusions by Ernst and Canter, who did not adhere to standard systematic review methodology, thus threatening the validity of their conclusions. There was no systematic assessment of the literature pertaining to the hazards of manipulation, including comparison to other therapies. Hence, their claim that the risks of manipulation outweigh the benefits, and thus spinal manipulation cannot be recommended as treatment for any condition, was not supported by the data analyzed. Their conclusions are misleading and not based on evidence that allow discrediting of a large body of professionals using spinal manipulation.

  15. C/EBPα Expression is Partially Regulated by C/EBPβ in Response to DNA Damage and C/EBPα Deficient Fibroblasts Display an Impaired G1 Checkpoint

    Science.gov (United States)

    Ranjan, Rakesh; Thompson, Elizabeth A.; Yoon, Kyungsil; Smart, Robert C.

    2009-01-01

    We observed that C/EBPα is highly inducible in primary fibroblasts by DNA damaging agents that induce strand breaks, alkylate and crosslink DNA as well as those that produce bulky DNA lesions. Fibroblasts deficient in C/EBPα (C/EBPα-/-) display an impaired G1 checkpoint as evidenced by inappropriate entry into S-phase in response to DNA damage and these cells also display an enhanced G1 to S transition in response to mitogens. The induction of C/EBPα by DNA damage in fibroblasts does not require p53. EMSA analysis of nuclear extracts prepared from UVB- and MNNG-treated fibroblasts revealed increased binding of C/EBPβ to a C/EBP consensus sequence and ChIP analysis revealed increased C/EBPβ binding to the C/EBPα promoter. To determine whether C/EBPβ has a role in the regulation of C/EBPα we treated C/EBPβ-/- fibroblasts with UVB or MNNG. We observed C/EBPα induction was impaired in both UVB- and MNNG- treated C/EBPβ-/- fibroblasts. Our study reveals a novel role for C/EBPβ in the regulation of C/EBPα in response to DNA damage and provides definitive genetic evidence that C/EBPα has a critical role in the DNA damage G1 checkpoint. PMID:19581927

  16. Conclusions and perspectives for Research and Political Practice

    DEFF Research Database (Denmark)

    Elling, Bo; Figueroa, Maria; Jelsøe, Erling

    2010-01-01

    In this article the authors concludes and identify what is the common and what is the challenges in the contributions to the anthology all together. They point out 4 emerging challenges for coming research agenda for sustainability: Sustainability and health, interdisciplinarity in empirical...... research, Social responsibility as element in sustainable development and linking sustainability and democracy....

  17. SMART Wind Turbine Rotor: Data Analysis and Conclusions

    Energy Technology Data Exchange (ETDEWEB)

    Berg, Jonathan C. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Barone, Matthew F. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Yoder, Nathanael C. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-01-29

    This report documents the data post-processing and analysis performed to date on the field test data. Results include the control capability of the trailing edge flaps, the combined structural and aerodynamic damping observed through application of step actuation with ensemble averaging, direct observation of time delays associated with aerodynamic response, and techniques for characterizing an operating turbine with active rotor control.

  18. It pays to be green. A premature conclusion?

    International Nuclear Information System (INIS)

    Telle, K.

    2006-01-01

    It has been claimed that good environmental performance can improve firms' economic performance. However, because of e.g. data limitations, the methods applied in most previous quantitative empirical studies on effects of environmental performance on economic performance of firms suffer from several shortcomings. We discuss these shortcomings and conclude that previously applied methods are unsatisfactory as support for a conclusion that it pays for firms to be green. Then we illustrate the consequences of these shortcomings by performing several regression analyses of the effect of environmental performance on economic performance using a panel data set of Norwegian plants. A pooled regression where observable firm characteristics like e.g. size or industry are controlled for, confirms a positive effect of environmental performance on economic performance. However, the estimated positive effect could be due to omitted unobserved variables like management or technology. When the regression model controls for unobserved plant heterogeneity, the effect is generally no longer statistically significant. Hence, although greener plants tend to perform economically better, the analysis provides little support for the claim that it is because they are greener. These empirical findings further indicate that a conclusion that it pays to be green is premature

  19. Conclusion of the I.C.T. benchmark exercise

    International Nuclear Information System (INIS)

    Giacometti, A.

    1991-01-01

    The ICT Benchmark exercise made within the RIV working group of ESARDA on reprocessing data supplied by COGEMA for 53 routines reprocessing input batches made of 110 irradiated fuel assemblies from KWO Nuclear Power Plant was finally evaluated. The conclusions are: all seven different ICT methods applied verified the operator data on plutonium within about one percent; anomalies intentionally introduced to the operator data were detected in 90% of the cases; the nature of the introduced anomalies, which were unknown to the participants, was completely resolved for the safeguards relevant cases; the false alarm rate was in a few percent range. The ICT Benchmark results shows that this technique is capable of detecting and resolving anomalies in the reprocessing input data to the order of a percent

  20. The no conclusion intervention for couples in conflict.

    Science.gov (United States)

    Migerode, Lieven

    2014-07-01

    Dealing with difference is central to all couple therapy. This article presents an intervention designed to assist couples in handling conflict. Central to this approach is the acceptance that most conflicts cannot be solved. Couples are in need of a different understanding of couples conflict. This understanding is found in the analysis of love in context and in relational dialectics. Couples are guided through different steps: deciding on the valence of the issue as individuals, helping them decide which differences can be resolved and which issues demand new ways of living with the inevitable, and the introduction in the suggested no conclusion dialogue. This article briefly describes the five day intensive couple therapy program, in which the no intervention is embedded. The theoretical foundation of the intervention, followed by the step by step description of the intervention forms the major part of the article. A case vignette illustrates this approach. © 2012 American Association for Marriage and Family Therapy.

  1. The European Food Consumption Validation Project: conclusions and recommendations

    DEFF Research Database (Denmark)

    de Boer, E. J.; Slimani, N.; van 't Veer, P.

    2011-01-01

    Background/Objectives: To outline and discuss the main results and conclusions of the European Food Consumption Validation (EFCOVAL) Project. Subjects/Methods: The EFCOVAL Project was carried out within the EU Sixth Framework Program by researchers in 11 EU countries. The activities focused on (1...... showed that two non-consecutive EPIC-Soft 24-HDRs are suitable to estimate the usual intake distributions of protein and potassium of European adult populations. The 2-day non-consecutive 24-HDRs in combination with a food propensity questionnaire also appeared to be appropriate to rank individuals...... according to their fish and fruit and vegetable intake in a comparable way in five European centers. Dietary intake of (young) children can be assessed by the combination of EPIC-Soft 24-HDRs and food recording booklets. The EPIC-Soft-standardized method of describing foods is useful to estimate dietary...

  2. The accident at the Harrisburg nuclear reactor - Interim conclusions

    International Nuclear Information System (INIS)

    Yiftah, S.

    1979-07-01

    This work describes the first minutes, first day and first week following the Three Mile Island accident. It shows the failures that occurred and the lessons which should be derived. It is pointed out that the doses of radiation that escaped from the TMI plant were at no time large enough to have had any effect on the 2 million people living on a radius of 80 km from the plant. Although no casualties occurred the Harrisburg accident will create an impulse for a new study and understanding of the nuclear plant safety and might serve as a live safety laboratory. After the TMI accident nuclear plants are already safer, one of the conclusions being that a new planning of the operation room is required, with the operators acquiring a better understanding of what is going on during a nuclear reactor accident. (B.G.)

  3. Workshop on large molten pool heat transfer summary and conclusions

    International Nuclear Information System (INIS)

    1994-01-01

    The CSNI Workshop on Large Molten Heat Transfer held at Grenoble (France) in March 1994 was organised by CSNI's Principal Working Group on the Confinement of Accidental Radioactive Releases (PWG4) with the cooperation of the Principal Working Group on Coolant System Behaviour (FWG2) and in collaboration with the Grenoble Nuclear Research Centre of the French Commissariat a l'Energie Atomique (CEA). Conclusions and recommendations are given for each of the five sessions of the workshops: Feasibility of in-vessel core debris cooling through external cooling of the vessel; Experiments on molten pool heat transfer; Calculational efforts on molten pool convection; Heat transfer to the surrounding water - experimental techniques; Future experiments and ex-vessel studies (open forum discussion)

  4. Jumping to conclusions and the continuum of delusional beliefs.

    Science.gov (United States)

    Warman, Debbie M; Lysaker, Paul H; Martin, Joel M; Davis, Louanne; Haudenschield, Samantha L

    2007-06-01

    The present study examined the jumping to conclusions reasoning bias across the continuum of delusional ideation by investigating individuals with active delusions, delusion prone individuals, and non-delusion prone individuals. Neutral and highly self-referent probabilistic reasoning tasks were employed. Results indicated that individuals with delusions gathered significantly less information than delusion prone and non-delusion prone participants on both the neutral and self-referent tasks, (preferent task (p=.002). Those with delusions and those who were delusion prone reported higher confidence in their performance on the self-referent task than they did the neutral task (p=.02), indicating that high self-reference impacted information processing for individuals in both of these groups. The results are discussed in relation to previous research in the area of probabilistic reasoning and delusions.

  5. Snakebites in French Guiana: Conclusions of an international symposium.

    Science.gov (United States)

    Kallel, Hatem; Hommel, Didier; Mehdaoui, Hossein; Megarbane, Bruno; Resiere, Dabor

    2018-05-01

    A workshop on epidemiology and management of snakebites in French Guiana was performed at Cayenne, French Guiana from September 15 to September 16, 2017, under the auspices of the French Regional Health Agency (ARS) and the Pan American Health Organization (PAHO). The activity was attended by experts from France (Angers, Martinique, French Guiana, Guadeloupe, and Paris), Costa Rica, Brazil, Saint Lucia, and Surinam. The epidemiology, clinical manifestations, clinical grading and the management of snakebite in French Guiana were discussed. The conclusions of this symposium illustrated the urgent need to ensure accessibility of effective and safe polyvalent viperid antivenom in French Guiana. Finally, the results of this symposium have forged ties based on mutual goals and objectives. Copyright © 2018 Elsevier Ltd. All rights reserved.

  6. Conclusions regarding geotechnical acceptability of the WIPP site

    International Nuclear Information System (INIS)

    Weart, W.D.

    1983-01-01

    The Waste Isolation Pilot Plant (WIPP) was authorized by Congress in 1980 as an unlicensed research and development (R and D) facility to demonstrate the safe disposal of radioactive wastes arising from the defense activities and programs of the United States. WIPP is now being constructed in southeast New Mexico, using salt beds about 655 m below the surface of the ground. Construction of the full WIPP facility will not commence until a preliminary underground excavation phase, called Site and Preliminary Design Validation (SPDV), is satisfactorily concluded in the summer of 1983. This SPDV program permits confirmation of subsurface geology, in drifts at planned facility depth that extend for 1555 m in a north-south direction, and in the two vertical shafts that provide access to these drifts. The subsurface studies are nearing completion, and it is therefore appropriate to draw conclusions regarding the geotechnical acceptability of the WIPP site. Four geotechnical elements are discussed: dissolution, deformation, hydrologic regime, and natural resources

  7. Fusion Energy Advisory Committee: Advice and recommendations to the Department of Energy in partial response to the Charge Letter of September 24, 1991: Part D

    International Nuclear Information System (INIS)

    1992-06-01

    This document is a compilation of the written records that relate to the Fusion Energy Advisory Committee's deliberations with regard to the Letter of Charge received from the Director of Energy Research, dated September 24, 1991. During its fourth meeting, held in May 1992, FEAC provided a detailed response to that part of the charge that requested review of the potential effectiveness, and hence the advisability, of implementing a more diverse US fusion program. In particular, it responded to the paragraph: ''By May 1992, 1 would like to have your recommendations on a US concept improvement program, including relative priorities and taking into account ongoing and planned work abroad.'' In order to respond to this charge in a timely manner, FEAC established a working group, designated ''Panel number-sign 3'', which reviewed the US and international fusion programs in detail and prepared background material, included in this report as Appendix 1, to help FEAC in its deliberations

  8. Partial characterization and response under hyperregulating conditions of Na+-K+ ATPase and levamisole-sensitive alkaline phosphatase activities in chela muscle of the euryhaline crab Cyrtograpsus angulatus

    Directory of Open Access Journals (Sweden)

    Silvina Andrea Pinoni

    2008-03-01

    Full Text Available The occurrence, characteristics and response to changes in environmental salinity of Na+-K+ ATPase and levamisole-sensitive alkaline phosphatase (AP activities were studied in chela muscle of the euryhaline crab Cyrtograpsus angulatus. Chela muscle exhibited an Na+-K+ ATPase activity which was strongly dependent on ATP concentration, pH and temperature of the reaction mixture. Maximal activity was found at 1 mM ATP, 30-37°C and pH 7.4. Levamisole-sensitive AP activity was characterised at physiological pH 7.4 and at pH 8.0. I50 for levamisole-sensitive AP activity was 8.8 mM and 8.0 mM at pH 7.4 and 8.0, respectively. At both pH levels, levamisole-sensitive AP activity exhibited Michaelis-Menten kinetics (Km=3.451 mM and 6.906 mM at pH 7.4 and 8.0, respectively. Levamisole-sensitive AP activities were strongly affected by temperature, exhibiting a peak at 37ºC. In crabs acclimated to low salinity (10; hyperegulating conditions, Na+-K+ ATPase activity and levamisole-sensitive AP activity at the physiological pH were higher than in 35 psu (osmoconforming conditions. The response to low salinity suggests that both activities could be components of muscle regulatory mechanisms at the biochemical level secondary to hyperegulation of C. angulatus. The study of these activities under hyperegulating conditions contributes to a better understanding of the complexity of biochemical mechanisms underlying the adaptive process of euryhaline crabs.

  9. How much is enough? Minimal responses of water quality and stream biota to partial retrofit stormwater management in a suburban neighborhood.

    Directory of Open Access Journals (Sweden)

    Allison H Roy

    Full Text Available Decentralized stormwater management approaches (e.g., biofiltration swales, pervious pavement, green roofs, rain gardens that capture, detain, infiltrate, and filter runoff are now commonly used to minimize the impacts of stormwater runoff from impervious surfaces on aquatic ecosystems. However, there is little research on the effectiveness of retrofit, parcel-scale stormwater management practices for improving downstream aquatic ecosystem health. A reverse auction was used to encourage homeowners to mitigate stormwater on their property within the suburban, 1.8 km(2 Shepherd Creek catchment in Cincinnati, Ohio (USA. In 2007-2008, 165 rain barrels and 81 rain gardens were installed on 30% of the properties in four experimental (treatment subcatchments, and two additional subcatchments were maintained as controls. At the base of the subcatchments, we sampled monthly baseflow water quality, and seasonal (5×/year physical habitat, periphyton assemblages, and macroinvertebrate assemblages in the streams for the three years before and after treatment implementation. Given the minor reductions in directly connected impervious area from the rain barrel installations (11.6% to 10.4% in the most impaired subcatchment and high total impervious levels (13.1% to 19.9% in experimental subcatchments, we expected minor or no responses of water quality and biota to stormwater management. There were trends of increased conductivity, iron, and sulfate for control sites, but no such contemporaneous trends for experimental sites. The minor effects of treatment on streamflow volume and water quality did not translate into changes in biotic health, and the few periphyton and macroinvertebrate responses could be explained by factors not associated with the treatment (e.g., vegetation clearing, drought conditions. Improvement of overall stream health is unlikely without additional treatment of major impervious surfaces (including roads, apartment buildings, and

  10. Conclusions, synthesis, and future directions: understanding sources of population change

    Science.gov (United States)

    Esler, Daniel N.; Flint, Paul L.; Derksen, Dirk V.; Savard, Jean-Pierre L.; Eadie, John M.

    2015-01-01

    The material in this volume reflects the burgeoning interest in sea ducks, both as study species with compelling and unique ecological attributes and as taxa of conservation concern. In this review, we provide perspective on the current state of sea duck knowledge by highlighting key findings in the preceding chapters that are of particular value for understanding or influencing population change. We also introduce a conceptual model that characterizes links among topics covered by individual chapters and places them in the context of demographic responses. Finally, we offer recommendations for areas of future research that we suggest will have importance for understanding and managing sea duck population dynamics.

  11. Hyperbolic partial differential equations

    CERN Document Server

    Witten, Matthew

    1986-01-01

    Hyperbolic Partial Differential Equations III is a refereed journal issue that explores the applications, theory, and/or applied methods related to hyperbolic partial differential equations, or problems arising out of hyperbolic partial differential equations, in any area of research. This journal issue is interested in all types of articles in terms of review, mini-monograph, standard study, or short communication. Some studies presented in this journal include discretization of ideal fluid dynamics in the Eulerian representation; a Riemann problem in gas dynamics with bifurcation; periodic M

  12. Successful removable partial dentures.

    Science.gov (United States)

    Lynch, Christopher D

    2012-03-01

    Removable partial dentures (RPDs) remain a mainstay of prosthodontic care for partially dentate patients. Appropriately designed, they can restore masticatory efficiency, improve aesthetics and speech, and help secure overall oral health. However, challenges remain in providing such treatments, including maintaining adequate plaque control, achieving adequate retention, and facilitating patient tolerance. The aim of this paper is to review the successful provision of RPDs. Removable partial dentures are a successful form of treatment for replacing missing teeth, and can be successfully provided with appropriate design and fabrication concepts in mind.

  13. Beginning partial differential equations

    CERN Document Server

    O'Neil, Peter V

    2011-01-01

    A rigorous, yet accessible, introduction to partial differential equations-updated in a valuable new edition Beginning Partial Differential Equations, Second Edition provides a comprehensive introduction to partial differential equations (PDEs) with a special focus on the significance of characteristics, solutions by Fourier series, integrals and transforms, properties and physical interpretations of solutions, and a transition to the modern function space approach to PDEs. With its breadth of coverage, this new edition continues to present a broad introduction to the field, while also addres

  14. Fusion Energy Advisory Committee: Advice and recommendations to the Department of Energy in partial response to the Charge Letter of September 24, 1991: Part C

    International Nuclear Information System (INIS)

    1992-04-01

    This document is a compilation of the written records that relate to the Fusion Energy Advisory Committee's deliberations with regard to the Letter of Charge received from the Director of Energy Research, dated September 24, 1991. During its third meeting, held in March 1992, FEAC provided a detailed response to that part of the charge that pertained to the period between the cessation of experiments on TFTR and the startup of experiments on ITER. In particular, it responded to the paragraph: ''By March 1992, 1 would like your views on how to fill the gap between the completion of TFTR work and the planned start of ITER operation. In addressing this issue, please include consideration of international collaboration, both here and abroad.'' In order to respond to this charge in a timely manner, FEAC established a working group, designated ''Panel number-sign 2'', which reviewed the proposed ITER program in detail and prepared background material, included in this report as Appendix II, to help FEAC in its deliberations

  15. Fusion Energy Advisory Committee: Advice and recommendations to the Department of Energy in partial response to the Charge Letter of September 24, 1991: Part A

    International Nuclear Information System (INIS)

    1991-10-01

    This document is a compilation of the written records that relate to the Fusion Energy Advisory Committee's initial deliberations with regard to the Letter of Charge received from the Director of Energy Research, dated September 24, 1991. In particular. during its first meeting in September 1991, FEAC provided its initial response to the three points of charge, which are outlined below: ''I would like to explore seriously the programmatic implications of this recommendation under two budget scenarios -- a constant dollar budget for magnetic fusion through FY 1996 and a budget at 5% real growth per year through FY 1996. I am therefore charging FEAC to advise me on the following questions. Identify how available funds now used for BPX, as well as a modest increase (described above) could be used to strengthen the eidsting base program for magnetic fusion research; within the above envelope of funding, identify what follow-on experimental devices for the US fusion program might be planned for use after the completion of experiments at TF-RR and before the planned start of ITER operation. For such devices, indicate how they would fit into the international fusion program; and what should be the US position on the appropriate scope, timing, and mission of ITER if BPX does not go forward?

  16. SMART wind turbine rotor. Data analysis and conclusions

    Energy Technology Data Exchange (ETDEWEB)

    Berg, Jonathan Charles; Barone, Matthew Franklin; Yoder, Nathanael C.

    2014-01-01

    The Wind Energy Technologies department at Sandia National Laboratories has developed and field tested a wind turbine rotor with integrated trailing-edge flaps designed for active control of the rotor aerodynamics. The SMART Rotor project was funded by the Wind and Water Power Technologies Office of the U.S. Department of Energy (DOE) and was conducted to demonstrate active rotor control and evaluate simulation tools available for active control research. This report documents the data post-processing and analysis performed to date on the field test data. Results include the control capability of the trailing edge flaps, the combined structural and aerodynamic damping observed through application of step actuation with ensemble averaging, direct observation of time delays associated with aerodynamic response, and techniques for characterizing an operating turbine with active rotor control.

  17. Ten-year study on acid precipitation nears conclusion

    International Nuclear Information System (INIS)

    Olem, H.

    1990-01-01

    Results from the National Acid Precipitation Assessment Program (NAPAP) are discussed. Final results are contained in 26 state of the science reports. Seven of the reports provide information on acid rain and aquatic ecosystems. They describe the current state of acidic surface waters, watershed processes affecting surface water chemistry, historical evidence for surface water acidification, methods for forecasting future changes, and the response of acidic surface water to liming. Six areas of the country were found to be of special interest: southwest Adirondacks, New England, forested areas of the mid-Atlantic highlands, the Atlantic coastal plain, the northern Florida highlands, parts of northeastern Wisconsin and the Upper Peninsula of Michigan. Environmental effects, mitigation efforts and possible legislation are briefly discussed

  18. Quantitation of regional cerebral blood flow corrected for partial volume effect using O-15 water and PET: II. Normal values and gray matter blood flow response to visual activation

    DEFF Research Database (Denmark)

    Law, I; Iida, H; Holm, S

    2000-01-01

    One of the most limiting factors for the accurate quantification of physiologic parameters with positron emission tomography (PET) is the partial volume effect (PVE). To assess the magnitude of this contribution to the measurement of regional cerebral blood flow (rCBF), the authors have formulated...... or 3D). Furthermore, the authors wanted to measure the activation response in the occipital gray matter compartment, and in doing so test the stability of the PTF, during perturbations of rCBF induced by visual stimulation. Eight dynamic PET scans were acquired per subject (n = 8), each for a duration...... of 6 minutes after IV bolus injection of H2(15)O. Four of these scans were performed using 2D and four using 3D acquisition. Visual stimulation was presented in four scans, and four scans were during rest. Model C was found optimal based on Akaike's Information Criteria (AIC) and had the smallest...

  19. Condition-dependent individual decision-making determines cyprinid partial migration

    DEFF Research Database (Denmark)

    Brodersen, J.; Nilsson, P.A.; Hansson, L.A.

    2008-01-01

    with decreased access to food. Furthermore, fewer unfed migrants returned to the lake, indicating higher overwinter mortality. Our results suggest that individual fish trade off safety from predation and access to food differently depending on their body condition, which results in a condition-dependent partial...... migration. Hence, our main conclusion is that individual decision-making is based on assessment of own condition which offers a mechanistic explanation to partial migration. Moreover, this may be of high importance for understanding population responses to environmental variation as well as ecosystem...

  20. Medical irradiation of children. Beware of too fast conclusion

    International Nuclear Information System (INIS)

    Brisse, H.; Sirinelli, D.; Adamsbaum, C.; Chateil, J.F.; Claudon, M.; Geoffray, A.; Petit, P.; Rausin, L.; Panuel, M.

    2004-01-01

    The publication in january 2004 in the British medical journal of the article of P. Hall and coll. 'Effect of low doses of ionizing irradiation in infancy on cognitive function in adulthood: Swedish population based cohort study, has been noticed by the Radiation protection group of the French speaking society of pediatrics imaging. The authors evaluate the psycho-motor development of less eighteen months years old children and irradiated between 1930 and 1959 for a face angioma. They study for each dose of irradiation ( from 0 to 250 m Gy) the level of school attendance and their results to the psycho-motor tests made during conscription medical examination. They noticed a diminution of 50% of the access success rate to university for the children having received an irradiation dose of 250 mG. No effect is noticed under the irradiation dose of 100 mGy. In their conclusions the authors compare these irradiation doses to these ones delivered in brain scanner examination. These results seem overestimated compared with the work made on fetuses ( publication 84 of ICRP) then the fetus is considered as more sensitive to ionizing radiations than the infant. The dose of 120 mGy is found in the literature and now the dose delivered in pediatrics are in the area of 0 and 100 mGy where no effect has been revealed in the cohort of irradiated children. The article does not include the principle of justification that is used nowadays and the replacement by the trans fontanel echography has allowed to reduce the number of brain scanner, used only for limited cases where the benefit is superior the the risk of irradiation. (N.C.)

  1. Plurihormonal cells of normal anterior pituitary: Facts and conclusions

    Science.gov (United States)

    Mitrofanova, Lubov B.; Konovalov, Petr V.; Krylova, Julia S.; Polyakova, Victoria O.; Kvetnoy, Igor M.

    2017-01-01

    Introduction plurihormonality of pituitary adenomas is an ability of adenoma cells to produce more than one hormone. After the immunohistochemical analysis had become a routine part of the morphological study, a great number of adenomas appeared to be multihormonal in actual practice. We hypothesize that the same cells of a normal pituitary gland releases several hormones simultaneously. Objective To analyse a possible co-expression of hormones by the cells of the normal anterior pituitary of adult humans in autopsy material. Materials and methods We studied 10 pituitary glands of 4 women and 6 men with cardiovascular and oncological diseases. Double staining immunohistochemistry using 11 hormone combinations was performed in all the cases. These combinations were: prolactin/thyroid-stimulating hormone (TSH), prolactin/luteinizing hormone (LH), prolactin/follicle-stimulating hormone (FSH), prolactin/adrenocorticotropic hormone (ACTH), growth hormone (GH)/TSH, GH/LH, GH/FSH, GH/ACTH, TSH/LH, TSH/FSH, TSH/ACTH. Laser Confocal Scanning Microscopy with a mixture of primary antibodies was performed in 2 cases. These mixtures were ACTH/prolactin, FSH/prolactin, TSH/prolactin, ACTH/GH, and FSH/GH. Results We found that the same cells of the normal adenohypophysis can co-express prolactin with ACTH, TSH, FSH, LH; GH with ACTH, TSH, FSH, LH, and TSH with ACTH, FSH, LH. The comparison of the average co-expression coefficients of prolactin, GH and TSH with other hormones showed that the TSH co-expression coefficient was significantly the least (9,5±6,9%; 9,6±7,8%; 1,0±1,3% correspondingly). Conclusion Plurihormonality of normal adenohypophysis is an actually existing phenomenon. Identification of different hormones in pituitary adenomas enables to find new ways to improve both diagnostic process and targeted treatment. PMID:28418929

  2. Waste Handling Shaft concrete liner degradation conclusions and recommendations

    International Nuclear Information System (INIS)

    1992-10-01

    The primary function of the Waste Handling Shaft (WHS) at the Waste Isolation Pilot Plant (WIPP) is to permit the transfer of radioactive waste from the surface waste handling building to the underground storage area. It also serves as an intake shaft for small volumes of air during normal storage operations and as an emergency escape route. Part of the construction was the placement of a concrete liner and steel reinforced key in 1984. During a routine shaft inspection in May 1990, some degradation of the WHS concrete liner was observed between the depths of 800 and 900 feet below the ground surface. Detailed investigations of the liner had been carried out by Sandia National Laboratories and by Westinghouse Electric Corporation Waste Isolation Division (WID) through Lankard Materials Laboratory. Observations, reports, and data support the conclusion that the concrete degradation, resulting from attack by chemically aggressive brine, is a localized phenomena. It is the opinion of the WID that the degradation is not considered an immediate or near term concern; this is supported by technical experts. WID recommendations have been made which, when implemented, will ensure an extended liner life. Based on the current assessment of available data and the proposed shaft liner monitoring program described in this report, it is reasonable to assume that the operational life of the concrete shaft liner can safely support the 25-year life of the WIPP. Analysis of data indicates that degradation of the shaft's concrete liner is attributed to chemically aggressive brine seeping through construction joints and shrinkage cracks from behind the liner in and around the 834-foot depth. Chemical and mechanical components of concrete degradation have been identified. Chemical attack is comprised of several stages of concrete alteration. The other component, mechanical degradation, results from the expansive forces of crystals forming in the concrete pore space

  3. The Danish energy crop research and development project - main conclusions

    International Nuclear Information System (INIS)

    Gylling, Morten

    2003-01-01

    Production of energy crops in Denmark is more or less non-existent in Denmark at the time being. However, the need for biomass on the other side of year 2005 exceeds the existing biomass resources and a substantial amount of energy crops will be necessary in order to fulfil the goals in Energy 21. The targeted share of the use of renewable energy sources by year 2030 is approximately 30%. Energy crops are seen as the most important new resource in order to create a balanced input mix of renewable in the energy system. The energy crops are mainly seen as fuel in small and medium sized CHP plants and in the big power plants. The Danish energy crop project consists of three main parts: a demonstration part, a research and development part, and an overall assessment part. Based on the results from the project the following overall conclusions can be made: Seen from a strictly market and production economic point of view energy crops will not be competitive in a foreseeable future, neither as a production for farmers nor as a fuel at the utility companies; The costs per GJ of energy crops are still higher than a GJ of straw; The cost difference between annual and perennial energy crops are slightly in favour of perennials, however the conditions on the individual farms should govern the choice between annual and perennial energy crops; Energy crops must be seen as part of an overall environmental scheme covering both agriculture and the energy sector; Given the right production scheme energy crops can be grown on environmental sensitive areas and on most ground water protection areas; Adding the potential sustainability benefits like reduced nutrient leakage and reduced CO 2 emissions energy crops seem to be a sensible and sustainable solution; Due to different handling, storage and fuel characteristics an all year delivery scheme of energy crops should include a mix of different energy crops to keep overall cost down. (BA)

  4. Partial knee replacement - slideshow

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/presentations/100225.htm Partial knee replacement - series—Normal anatomy To use the sharing ... A.M. Editorial team. Related MedlinePlus Health Topics Knee Replacement A.D.A.M., Inc. is accredited ...

  5. Beginning partial differential equations

    CERN Document Server

    O'Neil, Peter V

    2014-01-01

    A broad introduction to PDEs with an emphasis on specialized topics and applications occurring in a variety of fields Featuring a thoroughly revised presentation of topics, Beginning Partial Differential Equations, Third Edition provides a challenging, yet accessible,combination of techniques, applications, and introductory theory on the subjectof partial differential equations. The new edition offers nonstandard coverageon material including Burger's equation, the telegraph equation, damped wavemotion, and the use of characteristics to solve nonhomogeneous problems. The Third Edition is or

  6. Biologic comparison of partial breast irradiation protocols

    International Nuclear Information System (INIS)

    Rosenstein, Barry S.; Lymberis, Stella C.; Formenti, Silvia C.

    2004-01-01

    Purpose: To analyze the dose/fractionation schedules currently used in ongoing clinical trials of partial breast irradiation (PBI) by comparing their biologically effective dose (BED) values to those of three standard whole breast protocols commonly used after segmental mastectomy in the treatment of breast cancer. Methods and materials: The BED equation derived from the linear-quadratic model for radiation-induced cell killing was used to calculate the BEDs for three commonly used whole breast radiotherapy regimens, in addition to a variety of external beam radiotherapy, as well as high-dose-rate and low-dose-rate brachytherapy, PBI protocols. Results: The BED values of most PBI protocols resulted in tumor control BEDs roughly equivalent to a 50-Gy standard treatment, but consistently lower than the BEDs for regimens in which the tumor bed receives a total dose of either 60 Gy or 66 Gy. The BED values calculated for the acute radiation responses of erythema and desquamation were nearly all lower for the PBI schedules, and the late-response BEDs for most PBI regimens were in a similar range to the BEDs for the standard treatments. Conclusion: Biologically effective dose modeling raises the concern that inadequate doses might be delivered by PBI to ensure optimal in-field tumor control

  7. Defining the Attributes of a CBRN Human Response Model: Findings and Conclusions

    Science.gov (United States)

    2009-08-01

    others, were mentioned on a very limited basis  Military and civilian sectors both mentioned an interest in diseases for which military is... equine encephalitis, pertussis, measles, hepatitis, VHF, rabies, plague, burkholderia, and SEB. Two noted that biological agents might be less of a...as medical protection or detection/surveillance, even when the input is known, it may be null. For example, if the civilian sector knows that there

  8. Sex Differences in Moral Reasoning: Response to Walker's (1984) Conclusion That There Are None.

    Science.gov (United States)

    Baumrind, Diana

    1986-01-01

    Takes issue with Lawrence Walker's literature review on developmental and individual differences in moral reasoning which found no consistent evidence for sex differences in moral development. Argues instead that the source and specific nature of these differences have yet to be established. (HOD)

  9. CSNI/NEA Rasplav seminar 2000. Summary and conclusions

    International Nuclear Information System (INIS)

    2001-01-01

    various boundary conditions were investigated. The work involved a combination of integral and separate effect tests including molten-salt tests to investigate non-eutectic mixtures and the effects of stratification, extension of the material property database to allow interpretation and modelling of the experimental data. The CSNI decided to hold a seminar where the major outcome of the RASPLAV Project could be presented and discussed also in the context of other experienced activities on Severe Accidents. The objectives of the seminar are: - to review the experimental results of the RASPLAV Project; - to exchange information on complementary research; - to discuss the progress made on understanding severe accident progression; - to discuss the applicability to nuclear power plants and use of the results. The Seminar was intended to provide an in-depth review of the RASPLAV Project in terms of the technical capabilities, results and analyses produced during the project execution. The application of the results and their significance for power plant applications were addressed. Relevant results of the complementary research carried out at various laboratories were also presented. The seminar consisted of five sessions organised as follows: - Opening and overview; - Experimental results; - Theoretical Analyses; - Application and complementary research; - Conclusion

  10. Cosmological Gamma-Ray Bursts and Hypernovae Conclusively Linked

    Science.gov (United States)

    2003-06-01

    Clearest-Ever Evidence from VLT Spectra of Powerful Event Summary A very bright burst of gamma-rays was observed on March 29, 2003 by NASA's High Energy Transient Explorer (HETE-II) , in a sky region within the constellation Leo. Within 90 min, a new, very bright light source (the "optical afterglow") was detected in the same direction by means of a 40-inch telescope at the Siding Spring Observatory (Australia) and also in Japan. The gamma-ray burst was designated GRB 030329 , according to the date. And within 24 hours, a first, very detailed spectrum of this new object was obtained by the UVES high-dispersion spectrograph on the 8.2-m VLT KUEYEN telescope at the ESO Paranal Observatory (Chile). It allowed to determine the distance as about 2,650 million light-years (redshift 0.1685). Continued observations with the FORS1 and FORS2 multi-mode instruments on the VLT during the following month allowed an international team of astronomers [1] to document in unprecedented detail the changes in the spectrum of the optical afterglow of this gamma-ray burst . Their detailed report appears in the June 19 issue of the research journal "Nature". The spectra show the gradual and clear emergence of a supernova spectrum of the most energetic class known, a "hypernova" . This is caused by the explosion of a very heavy star - presumably over 25 times heavier than the Sun. The measured expansion velocity (in excess of 30,000 km/sec) and the total energy released were exceptionally high, even within the elect hypernova class. From a comparison with more nearby hypernovae, the astronomers are able to fix with good accuracy the moment of the stellar explosion. It turns out to be within an interval of plus/minus two days of the gamma-ray burst. This unique conclusion provides compelling evidence that the two events are directly connected. These observations therefore indicate a common physical process behind the hypernova explosion and the associated emission of strong gamma

  11. CSNI/NEA Rasplav seminar 2000. Summary and conclusions

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-01-15

    various boundary conditions were investigated. The work involved a combination of integral and separate effect tests including molten-salt tests to investigate non-eutectic mixtures and the effects of stratification, extension of the material property database to allow interpretation and modelling of the experimental data. The CSNI decided to hold a seminar where the major outcome of the RASPLAV Project could be presented and discussed also in the context of other experienced activities on Severe Accidents. The objectives of the seminar are: - to review the experimental results of the RASPLAV Project; - to exchange information on complementary research; - to discuss the progress made on understanding severe accident progression; - to discuss the applicability to nuclear power plants and use of the results. The Seminar was intended to provide an in-depth review of the RASPLAV Project in terms of the technical capabilities, results and analyses produced during the project execution. The application of the results and their significance for power plant applications were addressed. Relevant results of the complementary research carried out at various laboratories were also presented. The seminar consisted of five sessions organised as follows: - Opening and overview; - Experimental results; - Theoretical Analyses; - Application and complementary research; - Conclusion.

  12. Why is the conclusion of the Gerda experiment not justified

    Science.gov (United States)

    Klapdor-Kleingrothaus, H. V.; Krivosheina, I. V.

    2013-12-01

    The first results of the GERDA double beta experiment in Gran Sasso were recently presented. They are fully consistent with the HEIDELBERG-MOSCOW experiment, but because of its low statistics cannot proof anything at this moment. It is no surprise that the statistics is still far from being able to test the signal claimed by the HEIDELBERG-MOSCOW experiment. The energy resolution of the coaxial detectors is a factor of 1.5 worse than in the HEIDELBERG-MOSCOW experiment. The original goal of background reduction to 10-2 counts/kg y keV, or by an order of magnitude compared to the HEIDELBERG-MOSCOW experiment, has not been reached. The background is only a factor 2.3 lower if we refer it to the experimental line width, i.e. in units counts/kg y energy resolution. With pulse shape analysis ( PSA) the back-ground in the HEIDELBERG-MOSCOW experiment around Q ββ is 4 × 10-3 counts/kg y keV [1], which is a factor of 4 (5 referring to the line width) lower than that of GERDA with pulse shape analysis. The amount of enriched material used in the GERDA measurement is 14.6 kg, only a factor of 1.34 larger than that used in the HEIDELBERG-MOSCOW experiment. The background model is oversimplified and not yet adequate. It is not shown that the lines of their background can be identified. GERDA has to continue the measurement further ˜5 years, until they can responsibly present an understood background. The present half life limit presented by GERDA of T {1/2/0v} > 2.1 × 1025 y (90% confidence level, i.e. 1.6ρ) is still lower than the half-life of T {1/2/0v} = 2.23{-0.31/+0.44} × 1025 y [1] determined in the HEIDELBERG-MOSCOW experiment.

  13. Thin film devices used as oxygen partial pressure sensors

    Science.gov (United States)

    Canady, K. S.; Wortman, J. J.

    1970-01-01

    Electrical conductivity of zinc oxide films to be used in an oxygen partial pressure sensor is measured as a function of temperature, oxygen partial pressure, and other atmospheric constituents. Time response following partial pressure changes is studied as a function of temperature and environmental changes.

  14. Complex partial seizure, disruptive behaviours and the Nigerian ...

    African Journals Online (AJOL)

    Background: Complex partial seizure is an epileptic seizure which results in impairment of responsiveness or awareness such as altered level of consciousness. Complex partial seizures are often preceded by an aura such as depersonalization, feelings of de javu, jamais vu and fear. The ictal phase of complex partial ...

  15. Medical irradiation of children. Beware of too fast conclusion; Irradiation medicale de l'enfant. Attention aux conclusions hatives

    Energy Technology Data Exchange (ETDEWEB)

    Brisse, H. [Institut Curie, Dept. d' Imagerie, 75 - Paris (France); Sirinelli, D. [Hopital Clocheville, Service de Radiologie et Echographie, 37 - Tours (France); Adamsbaum, C. [Hopital Saint-Vincent-de-Paul, Service de Radiologie, 75 - Paris (France); Chateil, J.F. [Hopital Pellegrin, Unite de Radiopediatrie, 33 - Bordeaux (France); Claudon, M. [Centre Hospitalier Universitaire Nancy-Hopital Brabois Enfants, Service de Radiologie, 54 - Vandoeuvre-les-Nancy (France); Geoffray, A. [Fondation Lenval, Service de Radiologie, 06 - Nice (France); Petit, P. [Hopital de la Timone, Service de Radiologie, 13 - Marseille (France); Rausin, L. [Centre Hospitalier Regional de la Citadelle, Service de Radiologie, Liege (Belgium); Panuel, M. [Hopital Nord, Service de Radiologie, 13 - Marseille (France)

    2004-10-01

    The publication in january 2004 in the British medical journal of the article of P. Hall and coll. 'Effect of low doses of ionizing irradiation in infancy on cognitive function in adulthood: Swedish population based cohort study, has been noticed by the Radiation protection group of the French speaking society of pediatrics imaging. The authors evaluate the psycho-motor development of less eighteen months years old children and irradiated between 1930 and 1959 for a face angioma. They study for each dose of irradiation ( from 0 to 250 m Gy) the level of school attendance and their results to the psycho-motor tests made during conscription medical examination. They noticed a diminution of 50% of the access success rate to university for the children having received an irradiation dose of 250 mG. No effect is noticed under the irradiation dose of 100 mGy. In their conclusions the authors compare these irradiation doses to these ones delivered in brain scanner examination. These results seem overestimated compared with the work made on fetuses ( publication 84 of ICRP) then the fetus is considered as more sensitive to ionizing radiations than the infant. The dose of 120 mGy is found in the literature and now the dose delivered in pediatrics are in the area of 0 and 100 mGy where no effect has been revealed in the cohort of irradiated children. The article does not include the principle of justification that is used nowadays and the replacement by the trans fontanel echography has allowed to reduce the number of brain scanner, used only for limited cases where the benefit is superior the the risk of irradiation. (N.C.)

  16. Debris impact on emergency coolant recirculation - summary and conclusions

    International Nuclear Information System (INIS)

    Jain, Bhagwat; Hsia, Anthony; Armand, Yves; Mattei, Jean-Marie; Hyvaerinen, Juhani; Maqua, Michael; Puetter, Bernhard; Sandervaag, Oddbjoern; Vandewalle, Andre; Tombuyses, Beatrice; Pyy, Pekka; Royen, Jacques

    2004-01-01

    to two orders of magnitude because of strainer clogging. Consequently, the CSNI decided to continue its previous efforts in the area. The overall purpose of the 2004 Workshop was to discuss the impact of new information made available since 1996 and to promote consensus among member countries on identification of remaining technical issues important to safety, and on possible paths for their resolution. The specific purposes of the Workshop were: a. To review the knowledge base and in particular information developed after 1999, and to consider the validity of the conclusions drawn. b. To exchange information on the current status of research related to debris generation, debris transportation, and sump strainer clogging and penetration phenomena, in particular for PWRs, and to assess uncertainties. c. To exchange and disseminate information on recent and current activities and practices in these areas. d. To identify and discuss differences between approaches relevant to reactor safety. e. To identify technical issues and programs of interest for international collaborative research and develop an Action Plan outlining activities that CSNI should undertake in the area of strainer or sump screen clogging during the next few years. Summary of the main findings: a. The safety significance of the sump strainer clogging depends on the plant design (e.g. sump strainer, ECCS) and backfitting measures performed. b. The following are examples of PWR design features that could influence the debris impact on the ECCS sump performance: - Type of insulation (material, combination of materials, protection). - Break size to be postulated. - Transport in containment with or without containment spray system (CSS). - Degree of turbulence and flow velocities in the sump influenced by CSS, water level, break flow location and sump geometry. - Redundancy of sumps and residual heat removal system (RHRS). - Strainer design (area, mesh size). - Positioning of recirculation pumps and vortex

  17. The Alaska earthquake, March 27, 1964: lessons and conclusions

    Science.gov (United States)

    Eckel, Edwin B.

    1970-01-01

    local waves. Better earthquake-hazard maps, based on improved knowledge of regional geology, fault behavior, and earthquake mechanisms, are needed for the entire country. Their preparation will require the close collaboration of engineers, seismologists, and geologists. Geologic maps of all inhabited places in earthquake-prone parts of the country are also needed by city planners and others, because the direct relationship between local geology and potential earthquake damage is now well understood. Improved and enlarged nets of earthquake-sensing instruments, sited in relation to known geology, are needed, as are many more geodetic and hydrographic measurements. Every large earthquake, wherever located, should be regarded as a full-scale laboratory experiment whose study can give scientific and engineering information unobtainable from any other source. Plans must be made before the event to insure staffing, funding, and coordination of effort for the scientific and engineering study of future earthquakes. Advice of earth scientists and engineers should be used in the decision-making processes involved in reconstruction after any future disastrous earthquake, as was done after the Alaska earthquake. The volume closes with a selected bibliography and a comprehensive index to the entire series of U.S. Geological Survey Professional Papers 541-546. This is the last in a series of six reports that the U.S. Geological Survey published on the results of a comprehensive geologic study that began, as a reconnaissance survey, within 24 hours after the March 27, 1964, Magnitude 9.2 Great Alaska Earthquake and extended, as detailed investigations, through several field seasons. The 1964 Great Alaska earthquake was the largest earthquake in the U.S. since 1700. Professional Paper 546, in 1 part, describes Lessons and Conclusions.

  18. Regulatory aspects of management of change - Summary and conclusions

    International Nuclear Information System (INIS)

    2002-01-01

    Nuclear licensees are increasingly required to adapt to a more challenging commercial environment as moves to de-regulate electricity markets gather pace. One of the costs that is often perceived as being amenable to control is staffing, and hence there is significant exploration of new strategies for managing staffing levels. This report presents the outputs from a Workshop convened by the Special Experts' Group in Human and Organisational Factors (SEGHOF) of the Committee for the Safety of Nuclear Installations (CSNI) and organised by the UK Nuclear Installations Inspectorate (NII). The purpose of the workshop was to facilitate the exchange of views on, and approaches towards, the regulation of organisational change. The major risks associated with organisational change were discussed, and a range of regulatory challenges was identified for detailed discussion. There was agreement that the licensee must retain the responsibility to manage its own business but that organisational issues should be subject to regulatory scrutiny if they have the potential to impact on safety. The regulator should be able to demonstrate an approach to oversight of organisational change which is valid, transparent and consistent, and should inform the licensee of its expectations in terms of information supplied, communication and timing. The workshop confirmed that there is significant agreement between regulators concerning the need for licensees to put in place arrangements to manage organisational change. There was also broad consensus on what should constitute the elements of a licensee's management of change process. Differing views were evident about the balance between regulatory scrutiny of the process, as opposed to the outcomes of change, which largely represents differing regulatory regimes and philosophies. However, it was acknowledged that the regulator must be capable of taking an early view of the adequacy of proposed changes, rather than monitoring outcomes alone

  19. Forensic scientists' conclusions: how readable are they for non-scientist report-users?

    Science.gov (United States)

    Howes, Loene M; Kirkbride, K Paul; Kelty, Sally F; Julian, Roberta; Kemp, Nenagh

    2013-09-10

    Scientists have an ethical responsibility to assist non-scientists to understand their findings and expert opinions before they are used as decision-aids within the criminal justice system. The communication of scientific expert opinion to non-scientist audiences (e.g., police, lawyers, and judges) through expert reports is an important but under-researched issue. Readability statistics were used to assess 111 conclusions from a proficiency test in forensic glass analysis. The conclusions were written using an average of 23 words per sentence, and approximately half of the conclusions were expressed using the active voice. At an average Flesch-Kincaid Grade level of university undergraduate (Grade 13), and Flesch Reading Ease score of difficult (42), the conclusions were written at a level suitable for people with some tertiary education in science, suggesting that the intended non-scientist readers would find them difficult to read. To further analyse the readability of conclusions, descriptive features of text were used: text structure; sentence structure; vocabulary; elaboration; and coherence and unity. Descriptive analysis supported the finding that texts were written at a level difficult for non-scientists to read. Specific aspects of conclusions that may pose difficulties for non-scientists were located. Suggestions are included to assist scientists to write conclusions with increased readability for non-scientist readers, while retaining scientific integrity. In the next stage of research, the readability of expert reports in their entirety is to be explored. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  20. Partial differential equations

    CERN Document Server

    Evans, Lawrence C

    2010-01-01

    This text gives a comprehensive survey of modern techniques in the theoretical study of partial differential equations (PDEs) with particular emphasis on nonlinear equations. The exposition is divided into three parts: representation formulas for solutions; theory for linear partial differential equations; and theory for nonlinear partial differential equations. Included are complete treatments of the method of characteristics; energy methods within Sobolev spaces; regularity for second-order elliptic, parabolic, and hyperbolic equations; maximum principles; the multidimensional calculus of variations; viscosity solutions of Hamilton-Jacobi equations; shock waves and entropy criteria for conservation laws; and, much more.The author summarizes the relevant mathematics required to understand current research in PDEs, especially nonlinear PDEs. While he has reworked and simplified much of the classical theory (particularly the method of characteristics), he primarily emphasizes the modern interplay between funct...

  1. Optimization of partial search

    International Nuclear Information System (INIS)

    Korepin, Vladimir E

    2005-01-01

    A quantum Grover search algorithm can find a target item in a database faster than any classical algorithm. One can trade accuracy for speed and find a part of the database (a block) containing the target item even faster; this is partial search. A partial search algorithm was recently suggested by Grover and Radhakrishnan. Here we optimize it. Efficiency of the search algorithm is measured by the number of queries to the oracle. The author suggests a new version of the Grover-Radhakrishnan algorithm which uses a minimal number of such queries. The algorithm can run on the same hardware that is used for the usual Grover algorithm. (letter to the editor)

  2. Auxiliary partial liver transplantation

    NARCIS (Netherlands)

    C.B. Reuvers (Cornelis Bastiaan)

    1986-01-01

    textabstractIn this thesis studies on auxiliary partial liver transplantation in the dog and the pig are reported. The motive to perform this study was the fact that patients with acute hepatic failure or end-stage chronic liver disease are often considered to form too great a risk for successful

  3. Partial Remission Definition

    DEFF Research Database (Denmark)

    Andersen, Marie Louise Max; Hougaard, Philip; Pörksen, Sven

    2014-01-01

    OBJECTIVE: To validate the partial remission (PR) definition based on insulin dose-adjusted HbA1c (IDAA1c). SUBJECTS AND METHODS: The IDAA1c was developed using data in 251 children from the European Hvidoere cohort. For validation, 129 children from a Danish cohort were followed from the onset...

  4. Fundamental partial compositeness

    DEFF Research Database (Denmark)

    Sannino, Francesco; Strumia, Alessandro; Tesi, Andrea

    2016-01-01

    We construct renormalizable Standard Model extensions, valid up to the Planck scale, that give a composite Higgs from a new fundamental strong force acting on fermions and scalars. Yukawa interactions of these particles with Standard Model fermions realize the partial compositeness scenario. Unde...

  5. Partially ordered models

    NARCIS (Netherlands)

    Fernandez, R.; Deveaux, V.

    2010-01-01

    We provide a formal definition and study the basic properties of partially ordered chains (POC). These systems were proposed to model textures in image processing and to represent independence relations between random variables in statistics (in the later case they are known as Bayesian networks).

  6. Partially Hidden Markov Models

    DEFF Research Database (Denmark)

    Forchhammer, Søren Otto; Rissanen, Jorma

    1996-01-01

    Partially Hidden Markov Models (PHMM) are introduced. They differ from the ordinary HMM's in that both the transition probabilities of the hidden states and the output probabilities are conditioned on past observations. As an illustration they are applied to black and white image compression where...

  7. Honesty in partial logic

    NARCIS (Netherlands)

    W. van der Hoek (Wiebe); J.O.M. Jaspars; E. Thijsse

    1995-01-01

    textabstractWe propose an epistemic logic in which knowledge is fully introspective and implies truth, although truth need not imply epistemic possibility. The logic is presented in sequential format and is interpreted in a natural class of partial models, called balloon models. We examine the

  8. Conclusion conference

    International Nuclear Information System (INIS)

    Tubiana, M.

    1997-01-01

    Radioactive isotopes are the basis of spectacular advancements in biology, but also in medicine, not only indirectly with progress in disease and human body understanding, but also directly through nuclear medicine and radiotherapy. The important role of the Cea in the development of French radiotherapy, dosimetry and radioactive isotopes (especially cobalt) is reviewed

  9. Algebraic partial Boolean algebras

    International Nuclear Information System (INIS)

    Smith, Derek

    2003-01-01

    Partial Boolean algebras, first studied by Kochen and Specker in the 1960s, provide the structure for Bell-Kochen-Specker theorems which deny the existence of non-contextual hidden variable theories. In this paper, we study partial Boolean algebras which are 'algebraic' in the sense that their elements have coordinates in an algebraic number field. Several of these algebras have been discussed recently in a debate on the validity of Bell-Kochen-Specker theorems in the context of finite precision measurements. The main result of this paper is that every algebraic finitely-generated partial Boolean algebra B(T) is finite when the underlying space H is three-dimensional, answering a question of Kochen and showing that Conway and Kochen's infinite algebraic partial Boolean algebra has minimum dimension. This result contrasts the existence of an infinite (non-algebraic) B(T) generated by eight elements in an abstract orthomodular lattice of height 3. We then initiate a study of higher-dimensional algebraic partial Boolean algebras. First, we describe a restriction on the determinants of the elements of B(T) that are generated by a given set T. We then show that when the generating set T consists of the rays spanning the minimal vectors in a real irreducible root lattice, B(T) is infinite just if that root lattice has an A 5 sublattice. Finally, we characterize the rays of B(T) when T consists of the rays spanning the minimal vectors of the root lattice E 8

  10. PARTIAL REINFORCEMENT (ACQUISITION) EFFECTS WITHIN SUBJECTS.

    Science.gov (United States)

    AMSEL, A; MACKINNON, J R; RASHOTTE, M E; SURRIDGE, C T

    1964-03-01

    Acquisition performance of 22 rats in a straight alley runway was examined. The animals were subjected to partial reinforcement when the alley was black (B+/-) and continuous reinforcement when it was white (W+). The results indicated (a) higher terminal performance, for partial as against continuous reinforcement conditions, for starting-time and running-time measures, and (b) lower terminal performance under partial conditions for a goal-entry-time measure. These results confirm within subjects an effect previously demonstrated, in the runway, only in between-groups tests, where one group is run under partial reinforcement and a separate group is run under continuous reinforcement in the presence of the same external stimuli. Differences between the runway situation, employing a discrete-trial procedure and performance measures at three points in the response chain, and the Skinner box situation, used in its free-operant mode with a single performance measure, are discussed in relation to the present findings.

  11. A Generalized Partial Credit Model: Application of an EM Algorithm.

    Science.gov (United States)

    Muraki, Eiji

    1992-01-01

    The partial credit model with a varying slope parameter is developed and called the generalized partial credit model (GPCM). Analysis results for simulated data by this and other polytomous item-response models demonstrate that the rating formulation of the GPCM is adaptable to the analysis of polytomous item responses. (SLD)

  12. Compatriot partiality and cosmopolitan justice: Can we justify compatriot partiality within the cosmopolitan framework?

    Directory of Open Access Journals (Sweden)

    Rachelle Bascara

    2016-10-01

    Full Text Available This paper shows an alternative way in which compatriot partiality could be justified within the framework of global distributive justice. Philosophers who argue that compatriot partiality is similar to racial partiality capture something correct about compatriot partiality. However, the analogy should not lead us to comprehensively reject compatriot partiality. We can justify compatriot partiality on the same grounds that liberation movements and affirmative action have been justified. Hence, given cosmopolitan demands of justice, special consideration for the economic well-being of your nation as a whole is justified if and only if the country it identifies is an oppressed developing nation in an unjust global order.This justification is incomplete. We also need to say why Person A, qua national of Country A, is justified in helping her compatriots in Country A over similarly or slightly more oppressed non-compatriots in Country B. I argue that Person A’s partiality towards her compatriots admits further vindication because it is part of an oppressed group’s project of self-emancipation, which is preferable to paternalistic emancipation.Finally, I identify three benefits in my justification for compatriot partiality. First, I do not offer a blanket justification for all forms of compatriot partiality. Partiality between members of oppressed groups is only a temporary effective measure designed to level an unlevel playing field. Second, because history attests that sovereign republics could arise as a collective response to colonial oppression, justifying compatriot partiality on the grounds that I have identified is conducive to the development of sovereignty and even democracy in poor countries, thereby avoiding problems of infringement that many humanitarian poverty alleviation efforts encounter. Finally, my justification for compatriot partiality complies with the implicit cosmopolitan commitment to the realizability of global justice

  13. Effectiveness of add-on therapy with domperidone vs alginic acid in proton pump inhibitor partial response gastro-oesophageal reflux disease in systemic sclerosis: randomized placebo-controlled trial.

    Science.gov (United States)

    Foocharoen, Chingching; Chunlertrith, Kitti; Mairiang, Pisaln; Mahakkanukrauh, Ajanee; Suwannaroj, Siraphop; Namvijit, Suwassa; Wantha, Orathai; Nanagara, Ratanavadee

    2017-02-01

    Twice-daily dosing of proton pump inhibitor (PPI), the standard therapy for gastro-oesophageal reflux disease (GERD), is an effective therapy for GERD in SSc. The aim of this study was to compare the efficacy of omeprazole in combination with domperidone vs in combination with algycon in reducing the severity and frequency of reflux symptoms of PPI partial response (PPI-PR) GERD in SSc. Adult SSc patients having PPI-PR GERD were randomly assigned to receive domperidone plus algycon placebo or algycon plus domperidone placebo in a 1:1 ratio plus omeprazole for 4 weeks. The assessment included severity of symptom grading by visual analogue scale, frequency of symptoms by frequency scale for symptoms of GERD and quality of life (QoL) by EuroQol five-dimensions questionnaire scoring. One hundred and forty-eight SSc-GERD patients were enrolled, of whom 88 had PPI-PR. Eighty cases were randomized for either domperidone (n = 38) or algycon (n = 37) therapy. The majority in both groups had the diffuse SSc subset. At the end of the study, no significant difference in symptom grading was found between groups. After treatment and compared with baseline, the severity of symptoms, frequency scale for symptoms of GERD and QoL significantly improved in both groups. Five (13.2%) and 8 (21.6%) respective cases in the domperidone and algycon groups did not respond. The prevalence of PPI-PR GERD is common. Domperidone and algycon are equally effective treatments in combination with omeprazole. However, ∼17% of patients were non-responsive, so the effectiveness of domperidone, algycon and PPI combination therapy should be further investigated. https://clinicaltrials.gov (NCT01878526). © The Author 2016. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  14. Partially composite Higgs models

    DEFF Research Database (Denmark)

    Alanne, Tommi; Buarque Franzosi, Diogo; Frandsen, Mads T.

    2018-01-01

    We study the phenomenology of partially composite-Higgs models where electroweak symmetry breaking is dynamically induced, and the Higgs is a mixture of a composite and an elementary state. The models considered have explicit realizations in terms of gauge-Yukawa theories with new strongly...... interacting fermions coupled to elementary scalars and allow for a very SM-like Higgs state. We study constraints on their parameter spaces from vacuum stability and perturbativity as well as from LHC results and find that requiring vacuum stability up to the compositeness scale already imposes relevant...... constraints. A small part of parameter space around the classically conformal limit is stable up to the Planck scale. This is however already strongly disfavored by LHC results. in different limits, the models realize both (partially) composite-Higgs and (bosonic) technicolor models and a dynamical extension...

  15. Hierarchical partial order ranking

    International Nuclear Information System (INIS)

    Carlsen, Lars

    2008-01-01

    Assessing the potential impact on environmental and human health from the production and use of chemicals or from polluted sites involves a multi-criteria evaluation scheme. A priori several parameters are to address, e.g., production tonnage, specific release scenarios, geographical and site-specific factors in addition to various substance dependent parameters. Further socio-economic factors may be taken into consideration. The number of parameters to be included may well appear to be prohibitive for developing a sensible model. The study introduces hierarchical partial order ranking (HPOR) that remedies this problem. By HPOR the original parameters are initially grouped based on their mutual connection and a set of meta-descriptors is derived representing the ranking corresponding to the single groups of descriptors, respectively. A second partial order ranking is carried out based on the meta-descriptors, the final ranking being disclosed though average ranks. An illustrative example on the prioritisation of polluted sites is given. - Hierarchical partial order ranking of polluted sites has been developed for prioritization based on a large number of parameters

  16. Evaluation of Clinical and Pathological Response after Two Cycles ...

    African Journals Online (AJOL)

    Results: The clinical response rate was 83%; 11 patients (11.2%) had a complete clinical remission (cCR); 71 had a partial remission (72.4%); 13 had stable disease (13.3%), and 3 had progressive disease (3.1%). Seven patients had complete pathological response. Conclusion: Neoadjuvant chemotherapy can achieve a ...

  17. Thin film oxygen partial pressure sensor

    Science.gov (United States)

    Wortman, J. J.; Harrison, J. W.; Honbarrier, H. L.; Yen, J.

    1972-01-01

    The development is described of a laboratory model oxygen partial pressure sensor using a sputtered zinc oxide thin film. The film is operated at about 400 C through the use of a miniature silicon bar. Because of the unique resistance versus temperature relation of the silicon bar, control of the operational temperature is achieved by controlling the resistance. A circuit for accomplishing this is described. The response of sputtered zinc oxide films of various thicknesses to oxygen, nitrogen, argon, carbon dioxide, and water vapor caused a change in the film resistance. Over a large range, film conductance varied approximately as the square root of the oxygen partial pressure. The presence of water vapor in the gas stream caused a shift in the film conductance at a given oxygen partial pressure. A theoretical model is presented to explain the characteristic features of the zinc oxide response to oxygen.

  18. [Designing metal frame removable partial dentures

    NARCIS (Netherlands)

    Witter, D.J.; Barel, J.C.; Keltjens, H.M.A.M.; Creugers, N.H.J.

    2011-01-01

    Oral health care providers have the full responsibility for designing metal frame removable partial dentures and making all of the necessary preparations. Important principles of design are that the denture should hamper natural cleaning and daily oral hygiene as little as possible and that it

  19. Partially ordered algebraic systems

    CERN Document Server

    Fuchs, Laszlo

    2011-01-01

    Originally published in an important series of books on pure and applied mathematics, this monograph by a distinguished mathematician explores a high-level area in algebra. It constitutes the first systematic summary of research concerning partially ordered groups, semigroups, rings, and fields. The self-contained treatment features numerous problems, complete proofs, a detailed bibliography, and indexes. It presumes some knowledge of abstract algebra, providing necessary background and references where appropriate. This inexpensive edition of a hard-to-find systematic survey will fill a gap i

  20. Infinite partial summations

    International Nuclear Information System (INIS)

    Sprung, D.W.L.

    1975-01-01

    This paper is a brief review of those aspects of the effective interaction problem that can be grouped under the heading of infinite partial summations of the perturbation series. After a brief mention of the classic examples of infinite summations, the author turns to the effective interaction problem for two extra core particles. Their direct interaction is summed to produce the G matrix, while their indirect interaction through the core is summed in a variety of ways under the heading of core polarization. (orig./WL) [de

  1. On universal partial words

    OpenAIRE

    Chen, Herman Z. Q.; Kitaev, Sergey; Mütze, Torsten; Sun, Brian Y.

    2016-01-01

    A universal word for a finite alphabet $A$ and some integer $n\\geq 1$ is a word over $A$ such that every word in $A^n$ appears exactly once as a subword (cyclically or linearly). It is well-known and easy to prove that universal words exist for any $A$ and $n$. In this work we initiate the systematic study of universal partial words. These are words that in addition to the letters from $A$ may contain an arbitrary number of occurrences of a special `joker' symbol $\\Diamond\

  2. Partial differential equations

    CERN Document Server

    Agranovich, M S

    2002-01-01

    Mark Vishik's Partial Differential Equations seminar held at Moscow State University was one of the world's leading seminars in PDEs for over 40 years. This book celebrates Vishik's eightieth birthday. It comprises new results and survey papers written by many renowned specialists who actively participated over the years in Vishik's seminars. Contributions include original developments and methods in PDEs and related fields, such as mathematical physics, tomography, and symplectic geometry. Papers discuss linear and nonlinear equations, particularly linear elliptic problems in angles and gener

  3. Partial differential equations

    CERN Document Server

    Levine, Harold

    1997-01-01

    The subject matter, partial differential equations (PDEs), has a long history (dating from the 18th century) and an active contemporary phase. An early phase (with a separate focus on taut string vibrations and heat flow through solid bodies) stimulated developments of great importance for mathematical analysis, such as a wider concept of functions and integration and the existence of trigonometric or Fourier series representations. The direct relevance of PDEs to all manner of mathematical, physical and technical problems continues. This book presents a reasonably broad introductory account of the subject, with due regard for analytical detail, applications and historical matters.

  4. Partial differential equations

    CERN Document Server

    Sloan, D; Süli, E

    2001-01-01

    /homepage/sac/cam/na2000/index.html7-Volume Set now available at special set price ! Over the second half of the 20th century the subject area loosely referred to as numerical analysis of partial differential equations (PDEs) has undergone unprecedented development. At its practical end, the vigorous growth and steady diversification of the field were stimulated by the demand for accurate and reliable tools for computational modelling in physical sciences and engineering, and by the rapid development of computer hardware and architecture. At the more theoretical end, the analytical insight in

  5. Elliptic partial differential equations

    CERN Document Server

    Han, Qing

    2011-01-01

    Elliptic Partial Differential Equations by Qing Han and FangHua Lin is one of the best textbooks I know. It is the perfect introduction to PDE. In 150 pages or so it covers an amazing amount of wonderful and extraordinary useful material. I have used it as a textbook at both graduate and undergraduate levels which is possible since it only requires very little background material yet it covers an enormous amount of material. In my opinion it is a must read for all interested in analysis and geometry, and for all of my own PhD students it is indeed just that. I cannot say enough good things abo

  6. Generalized Partial Volume

    DEFF Research Database (Denmark)

    Darkner, Sune; Sporring, Jon

    2011-01-01

    Mutual Information (MI) and normalized mutual information (NMI) are popular choices as similarity measure for multimodal image registration. Presently, one of two approaches is often used for estimating these measures: The Parzen Window (PW) and the Generalized Partial Volume (GPV). Their theoret...... of view as well as w.r.t. computational complexity. Finally, we present algorithms for both approaches for NMI which is comparable in speed to Sum of Squared Differences (SSD), and we illustrate the differences between PW and GPV on a number of registration examples....

  7. Unilateral removable partial dentures.

    Science.gov (United States)

    Goodall, W A; Greer, A C; Martin, N

    2017-01-27

    Removable partial dentures (RPDs) are widely used to replace missing teeth in order to restore both function and aesthetics for the partially dentate patient. Conventional RPD design is frequently bilateral and consists of a major connector that bridges both sides of the arch. Some patients cannot and will not tolerate such an extensive appliance. For these patients, bridgework may not be a predictable option and it is not always possible to provide implant-retained restorations. This article presents unilateral RPDs as a potential treatment modality for such patients and explores indications and contraindications for their use, including factors relating to patient history, clinical presentation and patient wishes. Through case examples, design, material and fabrication considerations will be discussed. While their use is not widespread, there are a number of patients who benefit from the provision of unilateral RPDs. They are a useful treatment to have in the clinician's armamentarium, but a highly-skilled dental team and a specific patient presentation is required in order for them to be a reasonable and predictable prosthetic option.

  8. "Jumping to conclusions" in delusion-prone participants: an experimental economics approach.

    Science.gov (United States)

    van der Leer, Leslie; McKay, Ryan

    2014-01-01

    That delusional and delusion-prone individuals "jump to conclusions" on probabilistic reasoning tasks is a key finding in cognitive neuropsychiatry. Here we focused on a less frequently investigated aspect of "jumping to conclusions" (JTC): certainty judgments. We incorporated rigorous procedures from experimental economics to eliminate potential confounds of miscomprehension and motivation and systematically investigated the effect of incentives on task performance. Low- and high-delusion-prone participants (n = 109) completed a series of computerised trials; on each trial, they were shown a black or a white fish, caught from one of the two lakes containing fish of both colours in complementary ratios. In the betting condition, participants were given £4 to distribute over the two lakes as they wished; in the control condition, participants simply provided an estimate of how probable each lake was. Deviations from Bayesian probabilities were investigated. Whereas high-delusion-prone participants in both the control and betting conditions underestimated the Bayesian probabilities (i.e. were conservative), low-delusion-prone participants in the control condition underestimated but those in the betting condition provided accurate estimates. In the control condition, there was a trend for high-delusion-prone participants to give higher estimates than low-delusion-prone participants, which is consistent with previous reports of "jumping to conclusions" in delusion-prone participants. However, our findings in the betting condition, where high-delusion-prone participants provided lower estimates than low-delusion-prone participants (who were accurate), are inconsistent with the jumping-to-conclusions effect in both a relative and an absolute sense. Our findings highlight the key role of task incentives and underscore the importance of comparing the responses of delusion-prone participants to an objective rational standard as well as to the responses of non

  9. Tutorial on Online Partial Evaluation

    Directory of Open Access Journals (Sweden)

    William R. Cook

    2011-09-01

    Full Text Available This paper is a short tutorial introduction to online partial evaluation. We show how to write a simple online partial evaluator for a simple, pure, first-order, functional programming language. In particular, we show that the partial evaluator can be derived as a variation on a compositionally defined interpreter. We demonstrate the use of the resulting partial evaluator for program optimization in the context of model-driven development.

  10. Type-Directed Partial Evaluation

    DEFF Research Database (Denmark)

    Danvy, Olivier

    1998-01-01

    Type-directed partial evaluation uses a normalization function to achieve partial evaluation. These lecture notes review its background, foundations, practice, and applications. Of specific interest is the modular technique of offline and online type-directed partial evaluation in Standard ML...

  11. Type-Directed Partial Evaluation

    DEFF Research Database (Denmark)

    Danvy, Olivier

    1998-01-01

    Type-directed partial evaluation uses a normalization function to achieve partial evaluation. These lecture notes review its background, foundations, practice, and applications. Of specific interest is the modular technique of offline and online type-directed partial evaluation in Standard ML of ...

  12. A partial snake for the AGS

    International Nuclear Information System (INIS)

    Ratner, L.G.

    1990-01-01

    Based on snake experiments at the Indian University Cyclotron Facility and computer simulations at Brookhaven National Laboratory, as well as the conclusions of a BNL mini-workshop, we feel that a partial Siberian snake is a practical device for the AGS. It is anticipated that such a device could reduce the polarized beam tune-up time from 2--3 weeks to 2--3 days

  13. Response

    Science.gov (United States)

    Higgins, Chris

    2012-01-01

    This article presents the author's response to the reviews of his book, "The Good Life of Teaching: An Ethics of Professional Practice." He begins by highlighting some of the main concerns of his book. He then offers a brief response, doing his best to address the main criticisms of his argument and noting where the four reviewers (Charlene…

  14. Latest Cretaceous "A2-type" granites in the Sakarya Zone, NE Turkey: Partial melting of mafic lower crust in response to roll-back of Neo-Tethyan oceanic lithosphere

    Science.gov (United States)

    Karsli, Orhan; Aydin, Faruk; Uysal, Ibrahim; Dokuz, Abdurrahman; Kumral, Mustafa; Kandemir, Raif; Budakoglu, Murat; Ketenci, Murat

    2018-03-01

    An integrated study of comprehensive geochronological, geochemical, and Sr-Nd-Hf isotopic data was undertaken for the A-type Topcam pluton that intruded within the Sakarya Zone (NE Turkey) with the aims of elucidating its origin and tectonic significance and gaining new insights into the generation of aluminous A-type granites. New LA-ICP-MS zircon U-Pb crystallization ages of 72 and 73 Ma indicate emplacement in the Late Cretaceous time, just after extensive metaluminous I-type magmatism in the area. The pluton consists mainly of alkali feldspar, quartz, plagioclase, amphibole, and biotite with accessory minerals such as magnetite, apatite, and zircon. The outcrop is composed of granite, syenite, monzonite, and quartz monzonite and possesses a wide range of SiO2 content (57-70 wt%) with elevated Ga/Al ratios and low Mg# (mostly negative Eu (Eu/Eu* = 0.31 to 0.86) anomalies on the chondrite-normalized REE diagram. The rocks are enriched in some large ion lithophile elements (e.g., Rb, Th and Ba), and spidergrams show a relative depletion in Nb, Ti, and Sr. The granitic rocks of the pluton have identical 87Sr/86Sr(i) ratios ranging from 0.70518 to 0.70716, relatively low εNd (t) values varying from - 5.5 to - 0.4, and TDM ages (0.82-1.19 Ga). In situ zircon analyses show that the rocks have variable negative and positive εHf (t) values (- 5.5 to 5.9) and Hf two-stage model ages (742 to 1468 Ma), which are indicative of minor addition of juvenile material. Sr-Nd isotope modelling suggests mixing of 70-90% of lower crustal-derived melt with 10-30% of mantle-derived melt at lower crust depths. The heat source for partial melting is provided by upwelling of hot asthenosphere triggered by slab roll-back events. Geochemical and isotopic data reveal that metaluminous A2-type granites were derived from partial melting of the Paleozoic lower continental crust dominated by mafic rocks in amphibolitic composition, with minor input of subcontinental lithospheric mantle

  15. Applied partial differential equations

    CERN Document Server

    Logan, J David

    2004-01-01

    This primer on elementary partial differential equations presents the standard material usually covered in a one-semester, undergraduate course on boundary value problems and PDEs. What makes this book unique is that it is a brief treatment, yet it covers all the major ideas: the wave equation, the diffusion equation, the Laplace equation, and the advection equation on bounded and unbounded domains. Methods include eigenfunction expansions, integral transforms, and characteristics. Mathematical ideas are motivated from physical problems, and the exposition is presented in a concise style accessible to science and engineering students; emphasis is on motivation, concepts, methods, and interpretation, rather than formal theory. This second edition contains new and additional exercises, and it includes a new chapter on the applications of PDEs to biology: age structured models, pattern formation; epidemic wave fronts, and advection-diffusion processes. The student who reads through this book and solves many of t...

  16. Inductance loop and partial

    CERN Document Server

    Paul, Clayton R

    2010-01-01

    "Inductance is an unprecedented text, thoroughly discussing "loop" inductance as well as the increasingly important "partial" inductance. These concepts and their proper calculation are crucial in designing modern high-speed digital systems. World-renowned leader in electromagnetics Clayton Paul provides the knowledge and tools necessary to understand and calculate inductance." "With the present and increasing emphasis on high-speed digital systems and high-frequency analog systems, it is imperative that system designers develop an intimate understanding of the concepts and methods in this book. Inductance is a much-needed textbook designed for senior and graduate-level engineering students, as well as a hands-on guide for working engineers and professionals engaged in the design of high-speed digital and high-frequency analog systems."--Jacket.

  17. Fundamental partial compositeness

    CERN Document Server

    Sannino, Francesco

    2016-11-07

    We construct renormalizable Standard Model extensions, valid up to the Planck scale, that give a composite Higgs from a new fundamental strong force acting on fermions and scalars. Yukawa interactions of these particles with Standard Model fermions realize the partial compositeness scenario. Successful models exist because gauge quantum numbers of Standard Model fermions admit a minimal enough 'square root'. Furthermore, right-handed SM fermions have an SU(2)$_R$-like structure, yielding a custodially-protected composite Higgs. Baryon and lepton numbers arise accidentally. Standard Model fermions acquire mass at tree level, while the Higgs potential and flavor violations are generated by quantum corrections. We further discuss accidental symmetries and other dynamical features stemming from the new strongly interacting scalars. If the same phenomenology can be obtained from models without our elementary scalars, they would reappear as composite states.

  18. Fundamental partial compositeness

    International Nuclear Information System (INIS)

    Sannino, Francesco; Strumia, Alessandro; Tesi, Andrea; Vigiani, Elena

    2016-01-01

    We construct renormalizable Standard Model extensions, valid up to the Planck scale, that give a composite Higgs from a new fundamental strong force acting on fermions and scalars. Yukawa interactions of these particles with Standard Model fermions realize the partial compositeness scenario. Under certain assumptions on the dynamics of the scalars, successful models exist because gauge quantum numbers of Standard Model fermions admit a minimal enough ‘square root’. Furthermore, right-handed SM fermions have an SU(2)_R-like structure, yielding a custodially-protected composite Higgs. Baryon and lepton numbers arise accidentally. Standard Model fermions acquire mass at tree level, while the Higgs potential and flavor violations are generated by quantum corrections. We further discuss accidental symmetries and other dynamical features stemming from the new strongly interacting scalars. If the same phenomenology can be obtained from models without our elementary scalars, they would reappear as composite states.

  19. Partial oxidation process

    International Nuclear Information System (INIS)

    Najjar, M.S.

    1987-01-01

    A process is described for the production of gaseous mixtures comprising H/sub 2/+CO by the partial oxidation of a fuel feedstock comprising a heavy liquid hydrocarbonaceous fuel having a nickel, iron, and vanadium-containing ash or petroleum coke having a nickel, iron, and vanadium-containing ash, or mixtures thereof. The feedstock includes a minimum of 0.5 wt. % of sulfur and the ash includes a minimum of 5.0 wt. % vanadium, a minimum of 0.5 ppm nickel, and a minimum of 0.5 ppm iron. The process comprises: (1) mixing together a copper-containing additive with the fuel feedstock; wherein the weight ratio of copper-containing additive to ash in the fuel feedstock is in the range of about 1.0-10.0, and there is at least 10 parts by weight of copper for each part by weight of vanadium; (2) reacting the mixture from (1) at a temperature in the range of 2200 0 F to 2900 0 F and a pressure in the range of about 5 to 250 atmospheres in a free-flow refactory lined partial oxidation reaction zone with a free-oxygen containing gas in the presence of a temperature moderator and in a reducing atmosphere to produce a hot raw effluent gas stream comprising H/sub 2/+CO and entrained molten slag; and where in the reaction zone and the copper-containing additive combines with at least a portion of the nickel and iron constituents and sulfur found in the feedstock to produce a liquid phase washing agent that collects and transports at least a portion of the vanadium-containing oxide laths and spinels and other ash components and refractory out of the reaction zone; and (3) separating nongaseous materials from the hot raw effluent gas stream

  20. Partially massless graviton on beyond Einstein spacetimes

    Science.gov (United States)

    Bernard, Laura; Deffayet, Cédric; Hinterbichler, Kurt; von Strauss, Mikael

    2017-06-01

    We show that a partially massless graviton can propagate on a large set of spacetimes which are not Einstein spacetimes. Starting from a recently constructed theory for a massive graviton that propagates the correct number of degrees of freedom on an arbitrary spacetime, we first give the full explicit form of the scalar constraint responsible for the absence of a sixth degree of freedom. We then spell out generic conditions for the constraint to be identically satisfied, so that there is a scalar gauge symmetry which makes the graviton partially massless. These simplify if one assumes that spacetime is Ricci symmetric. Under this assumption, we find explicit non-Einstein spacetimes (some, but not all, with vanishing Bach tensors) allowing for the propagation of a partially massless graviton. These include in particular the Einstein static Universe.

  1. Experts' understanding of partial derivatives using the Partial Derivative Machine

    OpenAIRE

    Roundy, David; Dorko, Allison; Dray, Tevian; Manogue, Corinne A.; Weber, Eric

    2014-01-01

    Partial derivatives are used in a variety of different ways within physics. Most notably, thermodynamics uses partial derivatives in ways that students often find confusing. As part of a collaboration with mathematics faculty, we are at the beginning of a study of the teaching of partial derivatives, a goal of better aligning the teaching of multivariable calculus with the needs of students in STEM disciplines. As a part of this project, we have performed a pilot study of expert understanding...

  2. Partial Actions and Power Sets

    Directory of Open Access Journals (Sweden)

    Jesús Ávila

    2013-01-01

    Full Text Available We consider a partial action (X,α with enveloping action (T,β. In this work we extend α to a partial action on the ring (P(X,Δ,∩ and find its enveloping action (E,β. Finally, we introduce the concept of partial action of finite type to investigate the relationship between (E,β and (P(T,β.

  3. Algorithms over partially ordered sets

    DEFF Research Database (Denmark)

    Baer, Robert M.; Østerby, Ole

    1969-01-01

    in partially ordered sets, answer the combinatorial question of how many maximal chains might exist in a partially ordered set withn elements, and we give an algorithm for enumerating all maximal chains. We give (in § 3) algorithms which decide whether a partially ordered set is a (lower or upper) semi......-lattice, and whether a lattice has distributive, modular, and Boolean properties. Finally (in § 4) we give Algol realizations of the various algorithms....

  4. Anatomic partial nephrectomy: technique evolution.

    Science.gov (United States)

    Azhar, Raed A; Metcalfe, Charles; Gill, Inderbir S

    2015-03-01

    Partial nephrectomy provides equivalent long-term oncologic and superior functional outcomes as radical nephrectomy for T1a renal masses. Herein, we review the various vascular clamping techniques employed during minimally invasive partial nephrectomy, describe the evolution of our partial nephrectomy technique and provide an update on contemporary thinking about the impact of ischemia on renal function. Recently, partial nephrectomy surgical technique has shifted away from main artery clamping and towards minimizing/eliminating global renal ischemia during partial nephrectomy. Supported by high-fidelity three-dimensional imaging, novel anatomic-based partial nephrectomy techniques have recently been developed, wherein partial nephrectomy can now be performed with segmental, minimal or zero global ischemia to the renal remnant. Sequential innovations have included early unclamping, segmental clamping, super-selective clamping and now culminating in anatomic zero-ischemia surgery. By eliminating 'under-the-gun' time pressure of ischemia for the surgeon, these techniques allow an unhurried, tightly contoured tumour excision with point-specific sutured haemostasis. Recent data indicate that zero-ischemia partial nephrectomy may provide better functional outcomes by minimizing/eliminating global ischemia and preserving greater vascularized kidney volume. Contemporary partial nephrectomy includes a spectrum of surgical techniques ranging from conventional-clamped to novel zero-ischemia approaches. Technique selection should be tailored to each individual case on the basis of tumour characteristics, surgical feasibility, surgeon experience, patient demographics and baseline renal function.

  5. Partial order infinitary term rewriting

    DEFF Research Database (Denmark)

    Bahr, Patrick

    2014-01-01

    We study an alternative model of infinitary term rewriting. Instead of a metric on terms, a partial order on partial terms is employed to formalise convergence of reductions. We consider both a weak and a strong notion of convergence and show that the metric model of convergence coincides with th...... to the metric setting -- orthogonal systems are both infinitarily confluent and infinitarily normalising in the partial order setting. The unique infinitary normal forms that the partial order model admits are Böhm trees....

  6. Some Considerations on the Partial Credit Model

    OpenAIRE

    H.H.F.M. Verstralen; N.D. Verhelst

    2008-01-01

    The Partial Credit Model (PCM) is sometimes interpreted as a model for stepwise solution of polytomously scored items, where the item parameters are interpreted as di culties of the steps. It is argued that this interpretation is not justi ed. A model for stepwise solution is discussed. It is shown that the PCM is suited to model sums of binary responses which are not supposed to be stochastically independent. As a practical result, a statistical test of sto...

  7. The six most essential questions in psychiatric diagnosis: a pluralogue. Part 4: general conclusion

    Directory of Open Access Journals (Sweden)

    Phillips James

    2012-12-01

    Full Text Available Abstract In the conclusion to this multi-part article I first review the discussions carried out around the six essential questions in psychiatric diagnosis – the position taken by Allen Frances on each question, the commentaries on the respective question along with Frances’ responses to the commentaries, and my own view of the multiple discussions. In this review I emphasize that the core question is the first – what is the nature of psychiatric illness – and that in some manner all further questions follow from the first. Following this review I attempt to move the discussion forward, addressing the first question from the perspectives of natural kind analysis and complexity analysis. This reflection leads toward a view of psychiatric disorders – and future nosologies – as far more complex and uncertain than we have imagined.

  8. Respuesta productiva de conejos alimentados con forraje verde hidropónico de avena, como reemplazo parcial de concentrado comercial Productive response of rabbits fed with green hydroponic oats forage as partial replacement of commercial concentrate

    Directory of Open Access Journals (Sweden)

    Francisco Fabián Fuentes Carmona

    2011-04-01

    Full Text Available La respuesta productiva de conejos raza californiana alimentados con forraje verde hidropónico (FVH de avena como reemplazo parcial de concentrado comercial (CC, fue evaluada en condiciones de desierto en el norte de Chile. Se establecieron cinco tratamientos de alimentación, equivalentes a 0, 25, 50, 75 y 100% de reemplazo de la dieta diaria con FVH, el cual fue cosechado y utilizado directamente diez días después de la siembra. Cuarenta y cinco conejos destetados a los 31 días fueron evaluados en un diseño completamente al azar hasta alcanzar un peso de sacrificio de 2 kg de peso vivo. La calidad del FVH de avena fue considerada como buena, presentando similar valor nutritivo que el CC. Las variables evaluadas y sus respectivos rangos fueron: consumo de materia seca promedio (59.17 - 104.73 g/día, ganancia de peso vivo promedio (16.35 - 29.10 g/animal por día, conversión alimenticia promedio (3.31 - 3.93 kg MS/kg PV, tiempo de peso vivo a sacrificio (53 - 91 días, peso vivo final (1430 - 2044 g/animal, peso de la canal (1235 - 1385 g/animal y rendimiento de la canal (59.19 - 62.25%. El reemplazo de hasta 50% de la dieta base con FVH de avena no afectó significativamente (P The productive response of Californian rabbits fed with hydroponic green oats forage (HGOF as a partial replacement of commercial concentrate (CC was evaluated under desert conditions in northern Chile. Five treatments were established as follow: 0, 25, 50, 75 and 100% replacement of daily diet with HGOF, which was harvested and used directly at 10 days after sowing. Forty-five rabbits weaned at 31 days were evaluated in a completely randomized design until slaughter weight of 2.0 kg. HGOF quality was considered as good, presenting similar nutritional value to CC. The variables assessed and range values were: average dry matter intake (59.17-104.73 g/d, average weight gain (16.35-29.10 g/ rabbit for day, feed conversion average (3.31-3.93 kg DM/ kg LW, time of

  9. On Degenerate Partial Differential Equations

    OpenAIRE

    Chen, Gui-Qiang G.

    2010-01-01

    Some of recent developments, including recent results, ideas, techniques, and approaches, in the study of degenerate partial differential equations are surveyed and analyzed. Several examples of nonlinear degenerate, even mixed, partial differential equations, are presented, which arise naturally in some longstanding, fundamental problems in fluid mechanics and differential geometry. The solution to these fundamental problems greatly requires a deep understanding of nonlinear degenerate parti...

  10. [Acrylic resin removable partial dentures

    NARCIS (Netherlands)

    Baat, C. de; Witter, D.J.; Creugers, N.H.J.

    2011-01-01

    An acrylic resin removable partial denture is distinguished from other types of removable partial dentures by an all-acrylic resin base which is, in principle, solely supported by the edentulous regions of the tooth arch and in the maxilla also by the hard palate. When compared to the other types of

  11. Partial Epilepsy with Auditory Features

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2004-07-01

    Full Text Available The clinical characteristics of 53 sporadic (S cases of idiopathic partial epilepsy with auditory features (IPEAF were analyzed and compared to previously reported familial (F cases of autosomal dominant partial epilepsy with auditory features (ADPEAF in a study at the University of Bologna, Italy.

  12. Partial twisting for scalar mesons

    International Nuclear Information System (INIS)

    Agadjanov, Dimitri; Meißner, Ulf-G.; Rusetsky, Akaki

    2014-01-01

    The possibility of imposing partially twisted boundary conditions is investigated for the scalar sector of lattice QCD. According to the commonly shared belief, the presence of quark-antiquark annihilation diagrams in the intermediate state generally hinders the use of the partial twisting. Using effective field theory techniques in a finite volume, and studying the scalar sector of QCD with total isospin I=1, we however demonstrate that partial twisting can still be performed, despite the fact that annihilation diagrams are present. The reason for this are delicate cancellations, which emerge due to the graded symmetry in partially quenched QCD with valence, sea and ghost quarks. The modified Lüscher equation in case of partial twisting is given

  13. Cast Partial Denture versus Acrylic Partial Denture for Replacement of Missing Teeth in Partially Edentulous Patients

    Directory of Open Access Journals (Sweden)

    Pramita Suwal

    2017-03-01

    Full Text Available Aim: To compare the effects of cast partial denture with conventional all acrylic denture in respect to retention, stability, masticatory efficiency, comfort and periodontal health of abutments. Methods: 50 adult partially edentulous patient seeking for replacement of missing teeth having Kennedy class I and II arches with or without modification areas were selected for the study. Group-A was treated with cast partial denture and Group-B with acrylic partial denture. Data collected during follow-up visit of 3 months, 6 months, and 1 year by evaluating retention, stability, masticatory efficiency, comfort, periodontal health of abutment. Results: Chi-square test was applied to find out differences between the groups at 95% confidence interval where p = 0.05. One year comparison shows that cast partial denture maintained retention and stability better than acrylic partial denture (p< 0.05. The masticatory efficiency was significantly compromising from 3rd month to 1 year in all acrylic partial denture groups (p< 0.05. The comfort of patient with cast partial denture was maintained better during the observation period (p< 0.05. Periodontal health of abutment was gradually deteriorated in all acrylic denture group (p

  14. Does friendship give us non-derivative partial reasons ?

    Directory of Open Access Journals (Sweden)

    Andrew Reisner

    2008-02-01

    Full Text Available One way to approach the question of whether there are non-derivative partial reasons of any kind is to give an account of what partial reasons are, and then to consider whether there are such reasons. If there are, then it is at least possible that there are partial reasons of friendship. It is this approach that will be taken here, and it produces several interesting results. The first is a point about the structure of partial reasons. It is at least a necessary condition of a reason’s being partial that it has an explicit relational component. This component, technically, is a relatum in the reason relation that itself is a relation between the person to whom the reason applies and the person whom the action for which there is a reason concerns. The second conclusion of the paper is that this relational component is also required for a number of types of putatively impartial reasons. In order to avoid trivialising the distinction between partial and impartial reasons, some further sufficient condition must be applied. Finally, there is some prospect for a way of distinguishing between impartial reasons that contain a relational component and partial reasons, but that this approach suggests that the question of whether ethics is partial or impartial will be settled at the level of normative ethical discourse, or at least not at the level of discourse about the nature of reasons for action.

  15. Magnetic properties of partially oxidized Fe films

    Science.gov (United States)

    Garcia, Miguel Angel; Lopez-Dominguez, Victor; Hernando, Antonio

    Hybrid magnetic nanostructures exhibit appealing properties due to interface and proximity effects. A simple and interesting system of hybrid magnetic nanomaterials are partially oxidized ferromagnetic films. We have fabricated Fe films by thermal evaporation and performed a partial oxidation to magnetite (Fe3O4) by annealing in air at different times and temperatures. The magnetic properties of the films evolve from those of pure metallic iron to pure magnetite, showing intermediate states where the proximity effects control the magnetic behavior. At some stages, the magnetization curves obtained by SQUID and MOKE magnetometry exhibit important differences due to the dissimilar contribution of both phases to the magneto-optical response of the system This work has been supported by the Ministerio Español de Economia y Competitividad (MINECO) MAT2013-48009-C4-1. V.L.D and M.A.G. acknowledges financial support from BBVA foundation.

  16. Physics of partially ionized plasmas

    CERN Document Server

    Krishan, Vinod

    2016-01-01

    Plasma is one of the four fundamental states of matter; the other three being solid, liquid and gas. Several components, such as molecular clouds, diffuse interstellar gas, the solar atmosphere, the Earth's ionosphere and laboratory plasmas, including fusion plasmas, constitute the partially ionized plasmas. This book discusses different aspects of partially ionized plasmas including multi-fluid description, equilibrium and types of waves. The discussion goes on to cover the reionization phase of the universe, along with a brief description of high discharge plasmas, tokomak plasmas and laser plasmas. Various elastic and inelastic collisions amongst the three particle species are also presented. In addition, the author demonstrates the novelty of partially ionized plasmas using many examples; for instance, in partially ionized plasma the magnetic induction is subjected to the ambipolar diffusion and the Hall effect, as well as the usual resistive dissipation. Also included is an observation of kinematic dynam...

  17. Partially massless fields during inflation

    Science.gov (United States)

    Baumann, Daniel; Goon, Garrett; Lee, Hayden; Pimentel, Guilherme L.

    2018-04-01

    The representation theory of de Sitter space allows for a category of partially massless particles which have no flat space analog, but could have existed during inflation. We study the couplings of these exotic particles to inflationary perturbations and determine the resulting signatures in cosmological correlators. When inflationary perturbations interact through the exchange of these fields, their correlation functions inherit scalings that cannot be mimicked by extra massive fields. We discuss in detail the squeezed limit of the tensor-scalar-scalar bispectrum, and show that certain partially massless fields can violate the tensor consistency relation of single-field inflation. We also consider the collapsed limit of the scalar trispectrum, and find that the exchange of partially massless fields enhances its magnitude, while giving no contribution to the scalar bispectrum. These characteristic signatures provide clean detection channels for partially massless fields during inflation.

  18. Introduction to partial differential equations

    CERN Document Server

    Greenspan, Donald

    2000-01-01

    Designed for use in a one-semester course by seniors and beginning graduate students, this rigorous presentation explores practical methods of solving differential equations, plus the unifying theory underlying the mathematical superstructure. Topics include basic concepts, Fourier series, second-order partial differential equations, wave equation, potential equation, heat equation, approximate solution of partial differential equations, and more. Exercises appear at the ends of most chapters. 1961 edition.

  19. [Acrylic resin removable partial dentures].

    Science.gov (United States)

    de Baat, C; Witter, D J; Creugers, N H J

    2011-01-01

    An acrylic resin removable partial denture is distinguished from other types of removable partial dentures by an all-acrylic resin base which is, in principle, solely supported by the edentulous regions of the tooth arch and in the maxilla also by the hard palate. When compared to the other types of removable partial dentures, the acrylic resin removable partial denture has 3 favourable aspects: the economic aspect, its aesthetic quality and the ease with which it can be extended and adjusted. Disadvantages are an increased risk of caries developing, gingivitis, periodontal disease, denture stomatitis, alveolar bone reduction, tooth migration, triggering of the gag reflex and damage to the acrylic resin base. Present-day indications are ofa temporary or palliative nature or are motivated by economic factors. Special varieties of the acrylic resin removable partial denture are the spoon denture, the flexible denture fabricated of non-rigid acrylic resin, and the two-piece sectional denture. Furthermore, acrylic resin removable partial dentures can be supplied with clasps or reinforced by fibers or metal wires.

  20. Why do different criteria for 'cure' yield different conclusions in comparing two treatments for bacterial vaginosis?

    Science.gov (United States)

    Thomas, Katherine K; Sanchez, Sixto; Garcia, Patricia J; Holmes, King K

    2005-09-01

    The objective of this study was to determine why different criteria for response to treatment of bacterial vaginosis (BV) led to markedly different conclusions about treatment efficacy in a randomized trial comparing metronidazole gel versus metronidazole/nystatin ovules. We compared the impact of two treatment regimens on individual components of Amsel and Nugent criteria at follow-up visits 14, 42, and 104 days after initiating treatment. Compared with gel, ovules more effectively eliminated amines, clue cells, and Gardnerella, Prevotella, or Mobiluncus morphotypes from vaginal fluid, thus achieving cure based on "usual" criteria (absence of BV by Amsel or Nugent criteria), but did not more effectively restore Lactobacillus morphotypes or lower vaginal pH, thus not meeting Federal Drug Administration (FDA) criteria for cure. Because early vaginal recolonization by lactobacilli was poor after both gel and ovules, FDA draft criteria for cure missed marked differences in treatment efficacies against Gardnerella, clue cells, and amines. Cure defined more "usually" may give more useful information.

  1. Evaluating Behaviorally Oriented Aviation Maintenance Resource Management (MRM) Training and Programs: Methods, Results, and Conclusions

    Science.gov (United States)

    Taylor, James C.; Thomas, Robert L., III

    2003-01-01

    Assessment of the impact of Aviation Resource Management Programs on aviation culture and performance has compelled a considerable body of research (Taylor & Robertson, 1995; Taylor, 1998; Taylor & Patankar, 2001). In recent years new methods have been applied to the problem of maintenance error precipitated by factors such as the need for self-assessment of communication and trust. The present study - 2002 -- is an extension of that past work. This research project was designed as the conclusion of a larger effort to help understand, evaluate and validate the impact of Maintenance Resource Management (MRM) training programs, and other MRM interventions on participant attitudes, opinions, behaviors, and ultimately on enhanced safety performance. It includes research and development of evaluation methodology as well as examination of psychological constructs and correlates of maintainer performance. In particular, during 2002, three issues were addressed. First, the evaluation of two (independent & different) MRM programs for changing behaviors was undertaken. In one case we were able to further apply the approach to measuring written communication developed during 2001 (Taylor, 2002; Taylor & Thomas, 2003). Second, the MRM/TOQ surveys were made available for completion on the internet. The responses from these on-line surveys were automatically linked to a results calculator (like the one developed and described in Taylor, 2002) to aid industry users in analyzing and evaluating their local survey data on the internet. Third, the main trends and themes from our research about MRM programs over the past dozen years were reviewed.

  2. Conclusions from some unusual events in the field of ionizing radiation in the German Democratic Republic

    International Nuclear Information System (INIS)

    Schuettmann, W.; Koenig, W.

    1977-01-01

    In the GDR all unusual events in the field of ionizing radiation have been recorded and analysed since 1963. This is done by a central governmental institution, the National Board of Nuclear Safety and Radiation Protection established in 1962, and responsible for all relevant measures throughout the country. An unusual event is defined by radiation protection legislation as an event which deviates from the planned operation programme whether the incident has caused injury or not. The obligation to report such events rests on all licensed users, from users of X-ray machines to operators of reactors in research and nuclear power production. The listed events are continually assessed by the Board. The results of the assessment are evaluated in summary. There has not been a single event with a fatal outcome arising from ionizing radiation. Over the same period there were only seventeen occurrences which resulted in permanent injury to persons, mainly effected by acute external irradiation of parts of the body, especially of hands and forearms. Among the detected causes of unusual events described in detail, human failure predominates by far. Finally, conclusions are drawn from these results. The measures suggested all aim to reduce the frequency of radiation accidents and to minimize their consequences. The main measures concern ways of reducing human error in all fields of radiation protection. Among these, the education and training and the medical examination of radiation workers are discussed in somewhat more detail. (author)

  3. Gulf War Illnesses: DOD's Conclusions about U.S. Troops' Exposure Cannot Be Adequately Supported

    National Research Council Canada - National Science Library

    Rhodes, Keith

    2004-01-01

    ... (MOD) conclusions about troops' exposure. The GAO found that DoD's and MOD's conclusions about troops' exposure to CW agents, based on DoD and CIA plume modeling, cannot be adequately supported...

  4. Move Analysis of the Conclusion Sections of Research Papers in Persian and English

    Science.gov (United States)

    Zamani, Gerannaz; Ebadi, Saman

    2016-01-01

    The structure of the conclusion sections in Research Papers (RPs) is of significance in academic writing. The conclusion section in spite of providing an outline of the article, states other essential components, such as recommendations, implications and statements of possible lines of future research. This paper analyses the conclusion parts of…

  5. Partial hypopituitarism and Langerhans cell histiocytosis

    Science.gov (United States)

    Balaguruswamy, S; Chattington, P D

    2011-01-01

    A case of multisystem Langerhans cell histiocytosis with pituitary involvement nearly 20 years after initial presentation. A 48-year-old man had histiocytosis X 22 years ago initially involving the groin; subsequently his external auditory meatus, scalp, gum, mandibular bone, perineum and axilla were involved and treated. The pituitary gland was involved 4 years ago. A thyrotropin-releasing hormone test showed delayed response suggestive of hypothalamic disease. Prolactin levels were normal. A gonadotropin-releasing hormone test showed impaired testosterone and gonadotrophin response in keeping with pituitary disease. A glucagon stimulation test showed an impaired growth hormone response but a normal cortisol increase. MRI pituitary showed an empty sella. There was no evidence of diabetes insipidus. Bone mineral densitometry was normal. He has partial hypopituitarism needing thyroxine and testosterone replacement. He also developed type 2 diabetes mellitus 9 years ago. He is closely monitored for any development of diabetes insipidus and the need for growth hormone supplementation. PMID:22715201

  6. Conclusiveness of the Cochrane reviews in gynaecological cancer: A systematic analysis.

    Science.gov (United States)

    Yin, Shande; Chuai, Yunhai; Wang, Aiming; Zhang, Lanmei

    2015-06-01

    To assess the conclusiveness of Cochrane reviews in the field of gynaecological cancer. The Cochrane Library was searched for reviews regarding gynaecological cancer published between 1 January 2000 and 1 November 2014. Data were extracted from each paper and the conclusiveness of each review was assessed. The study included 66 reviews, 41 (62.1%) of which were conclusive. Of these, 58 included randomized controlled trials (RCTs), 37 (63.8%) of which were conclusive. Conclusive reviews of RCTs included significantly more patients than inconclusive reviews, but there was no difference in the number of included studies. Of the eight reviews of nonrandomized studies, four (50.0%) were conclusive. The majority of reviews recognized the need for additional studies. In the field of gynaecological cancer, reviews are more likely to be conclusive when they include RCTs, as well as large numbers of patients. © The Author(s) 2015 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

  7. Some Considerations on the Partial Credit Model

    Directory of Open Access Journals (Sweden)

    H.H.F.M. Verstralen

    2008-01-01

    Full Text Available The Partial Credit Model (PCM is sometimes interpreted as a model for stepwise solution of polytomously scored items, where the item parameters are interpreted as di culties of the steps. It is argued that this interpretation is not justi ed. A model for stepwise solution is discussed. It is shown that the PCM is suited to model sums of binary responses which are not supposed to be stochastically independent. As a practical result, a statistical test of stochastic independence in the Rasch model is derived

  8. Partial subclavian steal syndrome in a congenitally anomalous subclavian artery

    International Nuclear Information System (INIS)

    Krnic, A.; Sucic, Z.; Vucic, N.; Krolo, I.

    2006-01-01

    Background. A subclavian steal syndrome results from the abnormal flow of blood due to the occlusion in the subclavian artery proximal to the origin of the vertebral artery. A case of a male patient with a partial subclavian steal syndrome is presented. Case report. The syndrome was caused by a stenotic lesion of an aberrant right subclavian artery (the so called lusorian artery). The partial subclavian steal was recognized using the duplex ultrasound which showed the to and fro pattern in the right vertebral artery. Angiography of the aortic arch revealed the arterial anomaly. In our case, duplex ultrasound was a crucial method in diagnosing the partial subclavian steal syndrome. However, in order to show the arterial anomaly, the final evaluation had to be performed using arteriography. Conclusions. The early recognized partial subclavian steal syndrome provides good understanding of patient's symptoms, successful follow up, and a variety of treatment options. (author)

  9. Partial Transposition on Bipartite System

    International Nuclear Information System (INIS)

    Xi-Jun, Ren; Yong-Jian, Han; Yu-Chun, Wu; Guang-Can, Guo

    2008-01-01

    Many properties of partial transposition are unclear as yet. Here we carefully consider the number of the negative eigenvalues of ρ T (ρ's partial transposition) when ρ is a two-partite state. There is strong evidence to show that the number of negative eigenvalues of ρ T is N(N − 1)/2 at most when ρ is a state in Hilbert space C N C N . For the special case, the 2 × 2 system, we use this result to give a partial proof of the conjecture |ρ T | T ≥ 0. We find that this conjecture is strongly connected with the entanglement of the state corresponding to the negative eigenvalue of ρ T or the negative entropy of ρ

  10. Partial volume effect in MRI

    International Nuclear Information System (INIS)

    Maeda, Munehiro; Yoshiya, Kazuhiko; Suzuki, Eiji

    1989-01-01

    According to the direction and the thickness of the imaging slice in tomography, the border between the tissues becomes unclear (partial volume effect). In the present MRI experiment, we examined border area between fat and water components using phantom in order to investigate the partial volume effect in MRI. In spin echo sequences, the intensity of the border area showed a linear relationship with composition of fat and water. Whereas, in inversion recovery and field echo sequences, we found the parameters to produce an extremely low intensity area at the border region between fat and water. This low intensity area was explained by cancellation of NMR signals from fat and water due to the difference in the direction of magnetic vectors. Clinically, partial volume effect can cause of mis-evaluation of walls, small nodules, tumor capsules and the tumor invasion in the use of inversion recovery and field echo sequences. (author)

  11. Partially composite Goldstone Higgs boson

    DEFF Research Database (Denmark)

    Alanne, Tommi; Franzosi, Diogo Buarque; Frandsen, Mads T.

    2017-01-01

    We consider a model of dynamical electroweak symmetry breaking with a partially composite Goldstone Higgs boson. The model is based on a strongly interacting fermionic sector coupled to a fundamental scalar sector via Yukawa interactions. The SU(4)×SU(4) global symmetry of these two sectors...... is broken to a single SU(4) via Yukawa interactions. Electroweak symmetry breaking is dynamically induced by condensation due to the strong interactions in the new fermionic sector which further breaks the global symmetry SU(4)→Sp(4). The Higgs boson arises as a partially composite state which is an exact...... Goldstone boson in the limit where SM interactions are turned off. Terms breaking the SU(4) global symmetry explicitly generate a mass for the Goldstone Higgs boson. The model realizes in different limits both (partially) composite Higgs and (bosonic) technicolor models, thereby providing a convenient...

  12. New and renewable energy. Prospects for the 21st century. Conclusions in response to the Public Consultation

    International Nuclear Information System (INIS)

    2000-01-01

    This report gives details of the key elements of the UK government's policy on renewable energy sources and provides a guide to the new Renewables Obligation. The aims, strategy and targets of the government's policy, market stimulation, the Renewable Energy Obligation, the climate change levy, and the supporting programme including research, development, demonstration and dissemination are examined. Regional planning and targets are reviewed. (UK)

  13. Basic linear partial differential equations

    CERN Document Server

    Treves, Francois

    1975-01-01

    Focusing on the archetypes of linear partial differential equations, this text for upper-level undergraduates and graduate students features most of the basic classical results. The methods, however, are decidedly nontraditional: in practically every instance, they tend toward a high level of abstraction. This approach recalls classical material to contemporary analysts in a language they can understand, as well as exploiting the field's wealth of examples as an introduction to modern theories.The four-part treatment covers the basic examples of linear partial differential equations and their

  14. Elements of partial differential equations

    CERN Document Server

    Sneddon, Ian Naismith

    1957-01-01

    Geared toward students of applied rather than pure mathematics, this volume introduces elements of partial differential equations. Its focus is primarily upon finding solutions to particular equations rather than general theory.Topics include ordinary differential equations in more than two variables, partial differential equations of the first and second orders, Laplace's equation, the wave equation, and the diffusion equation. A helpful Appendix offers information on systems of surfaces, and solutions to the odd-numbered problems appear at the end of the book. Readers pursuing independent st

  15. Distal splenorenal shunt with partial spleen resection

    Directory of Open Access Journals (Sweden)

    Gajin Predrag

    2007-01-01

    postoperative platelet count between the first and second group, we found that there was a very significant statistical difference, too (p<0.01. Conclusion. Distal splenorenal shunt (Warren with partial spleen resection is a very reliable surgical technique in treatment of hypersplenism and decompression of oesophageal varices caused by portal hypertension and has advantage in treatment of hypersplenism over the distal splenorenal shunt method. .

  16. Monthly dynamics of carbon dioxide exchange across the sea surface of the Arctic Ocean in response to changes in gas transfer velocity and partial pressure of CO2 in 2010

    Directory of Open Access Journals (Sweden)

    Iwona Wrobel

    2017-10-01

    Full Text Available The Arctic Ocean (AO is an important basin for global oceanic carbon dioxide (CO2 uptake, but the mechanisms controlling air–sea gas fluxes are not fully understood, especially over short and long timescales. The oceanic sink of CO2 is an important part of the global carbon budget. Previous studies have shown that in the AO differences in the partial pressure of CO2 (ΔpCO2 and gas transfer velocity (k both contribute significantly to interannual air–sea CO2 flux variability, but that k is unimportant for multidecadal variability. This study combined Earth Observation (EO data collected in 2010 with the in situ pCO2 dataset from Takahashi et al. (2009 (T09 using a recently developed software toolbox called FluxEngine to determine the importance of k and ΔpCO2 on CO2 budgets in two regions of the AO – the Greenland Sea (GS and the Barents Sea (BS with their continental margins. Results from the study indicate that the variability in wind speed and, hence, the gas transfer velocity, generally play a major role in determining the temporal variability of CO2 uptake, while variability in monthly ΔpCO2 plays a major role spatially, with some exceptions.

  17. Acquisition with partial and continuous reinforcement in pigeon autoshaping.

    Science.gov (United States)

    Gottlieb, Daniel A

    2004-08-01

    Contemporary time accumulation models make the unique prediction that acquisition of a conditioned response will be equally rapid with partial and continuous reinforcement, if the time between conditioned stimuli is held constant. To investigate this, acquisition of conditioned responding was examined in pigeon autoshaping under conditions of 100% and 25% reinforcement, holding intertrial interval constant. Contrary to what was predicted, evidence for slowed acquisition in partially reinforced animals was observed with several response measures. However, asymptotic performance was superior with 25% reinforcement. A switching of reinforcement contingencies after initial acquisition did not immediately affect responding. After further sessions, partial reinforcement augmented responding, whereas continuous reinforcement did not, irrespective of an animal's reinforcement history. Subsequent training with a novel stimulus maintained the response patterns. These acquisition results generally support associative, rather than time accumulation, accounts of conditioning.

  18. Relationship between funding source and conclusion among nutrition-related scientific articles.

    Science.gov (United States)

    Lesser, Lenard I; Ebbeling, Cara B; Goozner, Merrill; Wypij, David; Ludwig, David S

    2007-01-01

    Industrial support of biomedical research may bias scientific conclusions, as demonstrated by recent analyses of pharmaceutical studies. However, this issue has not been systematically examined in the area of nutrition research. The purpose of this study is to characterize financial sponsorship of scientific articles addressing the health effects of three commonly consumed beverages, and to determine how sponsorship affects published conclusions. Medline searches of worldwide literature were used to identify three article types (interventional studies, observational studies, and scientific reviews) about soft drinks, juice, and milk published between 1 January, 1999 and 31 December, 2003. Financial sponsorship and article conclusions were classified by independent groups of coinvestigators. The relationship between sponsorship and conclusions was explored by exact tests and regression analyses, controlling for covariates. 206 articles were included in the study, of which 111 declared financial sponsorship. Of these, 22% had all industry funding, 47% had no industry funding, and 32% had mixed funding. Funding source was significantly related to conclusions when considering all article types (p = 0.037). For interventional studies, the proportion with unfavorable conclusions was 0% for all industry funding versus 37% for no industry funding (p = 0.009). The odds ratio of a favorable versus unfavorable conclusion was 7.61 (95% confidence interval 1.27 to 45.73), comparing articles with all industry funding to no industry funding. Industry funding of nutrition-related scientific articles may bias conclusions in favor of sponsors' products, with potentially significant implications for public health.

  19. Conclusiveness of fine needle aspiration in 2419 histologically confirmed benign and malignant breast lesions

    NARCIS (Netherlands)

    Kooistra, B.; Wauters, C.; Wobbes, T.; Strobbe, L.

    2011-01-01

    We aimed to retrospectively assess (1) the conclusiveness of breast fine needle aspiration (FNA) in a histologically confirmed population and (2) the clinical and radiologic determinants of a conclusive diagnosis. Aspirates were diagnosed as inadequate, benign, atypical, suspicious or malignant. We

  20. 20 CFR 410.471 - Conclusion by physician regarding miner's disability or death.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Conclusion by physician regarding miner's disability or death. 410.471 Section 410.471 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Total Disability or Death Due to Pneumoconiosis § 410.471 Conclusion...

  1. Timed Testing under Partial Observability

    DEFF Research Database (Denmark)

    David, Alexandre; Larsen, Kim Guldstrand; Li, Shuhao

    2009-01-01

    observability of SUT using a set of predicates over the TGA state space, and specify the test purposes in Computation Tree Logic (CTL) formulas. A recently developed partially observable timed game solver is used to generate winning strategies, which are used as test cases. We propose a conformance testing...

  2. Variable Selection via Partial Correlation.

    Science.gov (United States)

    Li, Runze; Liu, Jingyuan; Lou, Lejia

    2017-07-01

    Partial correlation based variable selection method was proposed for normal linear regression models by Bühlmann, Kalisch and Maathuis (2010) as a comparable alternative method to regularization methods for variable selection. This paper addresses two important issues related to partial correlation based variable selection method: (a) whether this method is sensitive to normality assumption, and (b) whether this method is valid when the dimension of predictor increases in an exponential rate of the sample size. To address issue (a), we systematically study this method for elliptical linear regression models. Our finding indicates that the original proposal may lead to inferior performance when the marginal kurtosis of predictor is not close to that of normal distribution. Our simulation results further confirm this finding. To ensure the superior performance of partial correlation based variable selection procedure, we propose a thresholded partial correlation (TPC) approach to select significant variables in linear regression models. We establish the selection consistency of the TPC in the presence of ultrahigh dimensional predictors. Since the TPC procedure includes the original proposal as a special case, our theoretical results address the issue (b) directly. As a by-product, the sure screening property of the first step of TPC was obtained. The numerical examples also illustrate that the TPC is competitively comparable to the commonly-used regularization methods for variable selection.

  3. Adaptive Partially Hidden Markov Models

    DEFF Research Database (Denmark)

    Forchhammer, Søren Otto; Rasmussen, Tage

    1996-01-01

    Partially Hidden Markov Models (PHMM) have recently been introduced. The transition and emission probabilities are conditioned on the past. In this report, the PHMM is extended with a multiple token version. The different versions of the PHMM are applied to bi-level image coding....

  4. Partially molten magma ocean model

    International Nuclear Information System (INIS)

    Shirley, D.N.

    1983-01-01

    The properties of the lunar crust and upper mantle can be explained if the outer 300-400 km of the moon was initially only partially molten rather than fully molten. The top of the partially molten region contained about 20% melt and decreased to 0% at 300-400 km depth. Nuclei of anorthositic crust formed over localized bodies of magma segregated from the partial melt, then grew peripherally until they coverd the moon. Throughout most of its growth period the anorthosite crust floated on a layer of magma a few km thick. The thickness of this layer is regulated by the opposing forces of loss of material by fractional crystallization and addition of magma from the partial melt below. Concentrations of Sr, Eu, and Sm in pristine ferroan anorthosites are found to be consistent with this model, as are trends for the ferroan anorthosites and Mg-rich suites on a diagram of An in plagioclase vs. mg in mafics. Clustering of Eu, Sr, and mg values found among pristine ferroan anorthosites are predicted by this model

  5. [Posterior ceramic bonded partial restorations].

    Science.gov (United States)

    Mainjot, Amélie; Vanheusden, Alain

    2006-01-01

    Posterior ceramic bonded partial restorations are conservative and esthetic approaches for compromised teeth. Overlays constitute a less invasive alternative for tooth tissues than crown preparations. With inlays and onlays they are also indicated in case of full arch or quadrant rehabilitations including several teeth. This article screens indications and realization of this type of restorations.

  6. Implementing circularity using partial evaluation

    DEFF Research Database (Denmark)

    Lawall, Julia Laetitia

    2001-01-01

    of an imperative C-like language, by extending the language with a new construct, persistent variables. We show that an extension of partial evaluation can eliminate persistent variables, producing a staged C program. This approach has been implemented in the Tempo specializer for C programs, and has proven useful...

  7. Partially coherent imaging and spatial coherence wavelets

    International Nuclear Information System (INIS)

    Castaneda, Roman

    2003-03-01

    A description of spatially partially coherent imaging based on the propagation of second order spatial coherence wavelets and marginal power spectra (Wigner distribution functions) is presented. In this dynamics, the spatial coherence wavelets will be affected by the system through its elementary transfer function. The consistency of the model with the both extreme cases of full coherent and incoherent imaging was proved. In the last case we obtained the classical concept of optical transfer function as a simple integral of the elementary transfer function. Furthermore, the elementary incoherent response function was introduced as the Fourier transform of the elementary transfer function. It describes the propagation of spatial coherence wavelets form each object point to each image point through a specific point on the pupil planes. The point spread function of the system was obtained by a simple integral of the elementary incoherent response function. (author)

  8. The partial-birth stratagem.

    Science.gov (United States)

    1998-06-01

    In Wisconsin, physicians stopped performing abortions when a Federal District Court Judge refused to issue a temporary restraining order against the state's newly enacted "partial birth" abortion ban that was couched in such vague language it actually covered all abortions. While ostensibly attempting to ban late-term "intact dilation and extraction," the language of the law did not refer to that procedure or to late terms. Instead, it prohibited all abortions in which a physician "partially vaginally delivers a living child, causes the death of the partially delivered child with the intent to kill the child and then completes the delivery of the child." The law also defined "child" as "a human being from the time of fertilization" until birth. It is clear that this abortion ban is unconstitutional under Row v. Wade, and this unconstitutionality is compounded by the fact that the law allowed no exception to protect a woman's health, which is required by Roe for abortion bans after fetal viability. Wisconsin is only one of about 28 states that have enacted similar laws, and only two have restricted the ban to postviability abortions. Many of these laws have been struck down in court, and President Clinton has continued to veto the Federal partial-birth bill. The Wisconsin Judge acknowledged that opponents of the ban will likely prevail when the case is heard, but his action in denying the temporary injunction means that many women in Wisconsin will not receive timely medical care. The partial birth strategy is really only another anti-abortion strategy.

  9. Partial axillary dissection in early breast cancer

    Directory of Open Access Journals (Sweden)

    Tarek Abdel Halim El-Fayoumi

    2013-09-01

    Full Text Available Background: In order to reduce the probability of later clinical involvement of the axilla and at establishing a sound basis for adjuvant treatment planning axillary dissection is an important operative procedure. So, partial axillary dissection has been applied to decrease the morbidity and postoperative axillary complications.Aim of the work was to study the reliability of partial axillary lymph node dissection in patients with breast carcinoma with clinically negative axilla. Methods: Eighteen patients underwent modified radical mastectomy, while the other two patients who were fulfilling the criteria for conservative breast surgery underwent lumpectomy. All patients did complete axillary lymph nodes dissection. Intraoperative leveling of the axilla was performed and level I axillary lymph nodes were identified according to their relation to pectoralis minor muscle; then they were subjected to intraoperative pathological examination by frozen section examination followed by complete axillary clearance. Then post operative histopathological examination of the tumor and all lymph nodes was done. Results: By intraoperative pathological examination; five patients (25% were found positive for malignant invasion, while 15 patients (75% were pathologically free. While paraffin section showed six patients (30% with malignant invasion, and 14 patients (70% were pathologically free. There was a false negative rate of 5% in level I axillary lymph nodes by intraoperative pathological examination which was positive for metastasis by paraffin section that revealed microinvasion in one lymph node out of 8 in level I. Only two cases out of 20 were found positive for metastasis in level II and III. Conclusion: Partial axillary lymph node dissection is a minimally invasive, feasible and sufficient technique that can predict the axillary lymph node status. KEYWORDS: Breast cancer, Axillary lymph nodes clearance

  10. Ecological advantages of partial migration as a conditional strategy.

    Science.gov (United States)

    Vélez-Espino, Luis A; McLaughlin, Robert L; Robillard, Melissa

    2013-05-01

    Partial migration is a widespread phenomenon characterized by migrant and resident forms from the same population. In phenotypically plastic taxa with indeterminate growth, resident and migrant ecophenotypes can differ in size and life history traits in ways expected to maximize fitness in the different habitats they exploit. Studies of partial migration in different taxa have advocated either density-dependence or environmental stochasticity as explanations for partial migration. We used a demographic approach for a virtual Brook Trout population to demonstrate the ecological consequences of partial migration under interacting density dependence and environmental stochasticity. The maintenance of partial migration as a conditional strategy in species/populations where resident and migrant forms exhibit life history asymmetries provides ecological advantages. We show that density-dependent migration is expected to increase population fitness under constant environmental conditions or low environmental variation, but decreases population fitness under high environmental variation. These conditions favor intermediate levels of migration as an advantageous tactic. However, there are threshold rates of return migration below which partial migration is no longer a viable tactic. Our modeling approach also allowed the exploration of the distribution of the population by life stage and habitat in response to the strength of density dependence, costs of migration, and return rates, and demonstrated the importance of the conservation of ecophenotypes in partially migratory populations. Copyright © 2013 Elsevier Inc. All rights reserved.

  11. Partial Facetectomy for Lumbar Foraminal Stenosis

    Directory of Open Access Journals (Sweden)

    Kevin Kang

    2014-01-01

    Full Text Available Background. Several different techniques exist to address the pain and disability caused by isolated nerve root impingement. Failure to adequately decompress the lumbar foramen may lead to failed back surgery syndrome. However, aggressive treatment often causes spinal instability or may require fusion for satisfactory results. We describe a novel technique for decompression of the lumbar nerve root and demonstrate its effectiveness in relief of radicular symptoms. Methods. Partial facetectomy was performed by removal of the medial portion of the superior facet in patients with lumbar foraminal stenosis. 47 patients underwent the procedure from 2001 to 2010. Those who demonstrated neurogenic claudication without spinal instability or central canal stenosis and failed conservative management were eligible for the procedure. Functional level was recorded for each patient. These patients were followed for an average of 3.9 years to evaluate outcomes. Results. 27 of 47 patients (57% reported no back pain and no functional limitations. Eight of 47 patients (17% reported moderate pain, but had no limitations. Six of 47 patients (13% continued to experience degenerative symptoms. Five of 47 patients (11% required additional surgery. Conclusions. Partial facetectomy is an effective means to decompress the lumbar nerve root foramen without causing spinal instability.

  12. Physics analysis of the gang partial rod drive event

    International Nuclear Information System (INIS)

    Boman, C.; Frost, R.L.

    1992-08-01

    During the routine positioning of partial-length control rods in Gang 3 on the afternoon of Monday, July 27, 1992, the partial-length rods continued to drive into the reactor even after the operator released the controlling toggle switch. In response to this occurrence, the Safety Analysis and Engineering Services Group (SAEG) requested that the Applied Physics Group (APG) analyze the gang partial rod drive event. Although similar accident scenarios were considered in analysis for Chapter 15 of the Safety Analysis Report (SAR), APG and SAEG conferred and agreed that this particular type of gang partial-length rod motion event was not included in the SAR. This report details this analysis

  13. Phylogenetic search through partial tree mixing

    Science.gov (United States)

    2012-01-01

    Background Recent advances in sequencing technology have created large data sets upon which phylogenetic inference can be performed. Current research is limited by the prohibitive time necessary to perform tree search on a reasonable number of individuals. This research develops new phylogenetic algorithms that can operate on tens of thousands of species in a reasonable amount of time through several innovative search techniques. Results When compared to popular phylogenetic search algorithms, better trees are found much more quickly for large data sets. These algorithms are incorporated in the PSODA application available at http://dna.cs.byu.edu/psoda Conclusions The use of Partial Tree Mixing in a partition based tree space allows the algorithm to quickly converge on near optimal tree regions. These regions can then be searched in a methodical way to determine the overall optimal phylogenetic solution. PMID:23320449

  14. The strategic value of partial vertical integration

    OpenAIRE

    Fiocco, Raffaele

    2014-01-01

    We investigate the strategic incentives for partial vertical integration, namely, partial ownership agreements between manufacturers and retailers, when retailers privately know their costs and engage in differentiated good price competition. The partial misalignment between the profit objectives within a partially integrated manufacturer-retailer hierarchy entails a higher retail price than under full integration. This `information vertical effect' translates into an opposite ...

  15. 32 CFR 751.13 - Partial payments.

    Science.gov (United States)

    2010-07-01

    ... voucher and all other information related to the partial payment shall be placed in the claim file. Action... 32 National Defense 5 2010-07-01 2010-07-01 false Partial payments. 751.13 Section 751.13 National... Claims Against the United States § 751.13 Partial payments. (a) Partial payments when hardship exists...

  16. Conclusions of the presidency. European council of Barcelona, March 15 and 16 2002; Conclusions de la presidence. Conseil europeen de Barcelone 15 et 16 mars 2002

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    This document summarizes the conclusions of the European Council held in Barcelona (Spain) on March 15 and 16, 2002. Among the priority actions listed by the council figure the integration of energy, transportation and communication networks at the European scale. In particular, the council commits the Parliament and itself to start the final phase of opening of gas and electricity markets: free choice of a supplier, obligation of public utility, security of supplies, separation between transmission and distribution and between production and supply, non-discriminatory access of consumers and suppliers to networks with transparent tariffs, establishment of a regulatory agency in each member state, agreement for a tariffing system for the international electricity trades etc.. Concerning the sustainable development strategy of the European union, the council is pressing the member states for the completion of the national procedures of ratification of the Kyoto protocol. However, new measures need to be taken to develop technologies respectful for the environment, in particular in the domain of energy and transports. (J.S.)

  17. Evaluation of partial beta-adrenoceptor agonist activity.

    Science.gov (United States)

    Lipworth, B J; Grove, A

    1997-01-01

    A partial beta-adrenoceptor (beta-AR) agonist will exhibit opposite agonist and antagonist activity depending on the prevailing degree of adrenergic tone or the presence of a beta-AR agonist with higher intrinsic activity. In vivo partial beta-AR agonist activity will be evident at rest with low endogenous adrenergic tone, as for example with chronotropicity (beta 1/beta 2), inotropicity (beta 1) or peripheral vasodilatation and finger tremor (beta 2). beta-AR blocking drugs which have partial agonist activity may exhibit a better therapeutic profile when used for hypertension because of maintained cardiac output without increased systemic vascular resistance, along with an improved lipid profile. In the presence of raised endogenous adrenergic tone such as exercise or an exogenous full agonist, beta-AR subtype antagonist activity will become evident in terms of effects on exercise induced heart rate (beta 1) and potassium (beta 2) responses. Reduction of exercise heart rate will occur to a lesser degree in the case of a beta-adrenoceptor blocker with partial beta 1-AR agonist activity compared with a beta-adrenoceptor blocker devoid of partial agonist activity. This may result in reduced therapeutic efficacy in the treatment of angina on effort when using beta-AR blocking drugs with partial beta 1-AR agonist activity. Effects on exercise hyperkalaemia are determined by the balance between beta 2-AR partial agonist activity and endogenous adrenergic activity. For predominantly beta 2-AR agonist such as salmeterol and salbutamol, potentiation of exercise hyperkalaemia occurs. For predominantly beta 2-AR antagonists such as carteolol, either potentiation or attenuation of exercise hyperkalaemia occurs at low and high doses respectively. beta 2-AR partial agonist activity may also be expressed as antagonism in the presence of an exogenous full agonist, as for example attenuation of fenoterol induced responses by salmeterol. Studies are required to investigate whether

  18. Fracture strength and bending of all-ceramic and fiber-reinforced composites in inlay-retained fixed partial dentures

    Directory of Open Access Journals (Sweden)

    Serkan Saridag

    2012-06-01

    Conclusions: Zirconia-based ceramic inlay-retained fixed partial dentures demonstrated the highest fracture strength. The fiber-reinforced composite inlay-retained fixed partial dentures demonstrated higher bending values than did the all-ceramic inlay-retained fixed partial dentures.

  19. Three Mile Island unit 2 vessel investigation project. Conclusions and significance

    International Nuclear Information System (INIS)

    Beckjord, E.S.

    1994-01-01

    At the conclusion of the TMI-2 Vessel Investigation Project, additional insights about the accident have been gained, specifically in the area of reactor vessel integrity and the conditions of the lower head of the reactor vessel. This paper discusses three topics: the evolving views about the TMI-2 accident scenario over time, the technical conclusions of the TMI-2 VIP (recovery of samples from the vessel lower head), and the broad significance of these findings (accident management). 4 refs

  20. Funding source, conflict of interest and positive conclusions in neuro-oncology clinical trials.

    Science.gov (United States)

    Moraes, Fabio Y; Mendez, Lucas C; Taunk, Neil K; Raman, Srinivas; Suh, John H; Souhami, Luis; Slotman, Ben; Weltman, Eduardo; Spratt, Daniel E; Berlin, Alejandro; Marta, Gustavo N

    2018-02-01

    We aimed to test any association between authors' conclusions and self-reported COI or funding sources in central nervous system (CNS) studies. A review was performed for CNS malignancy clinical trials published in the last 5 years. Two investigators independently classified study conclusions according to authors' endorsement of the experimental therapy. Statistical models were used to test for associations between positive conclusions and trials characteristics. From February 2010 to February 2015, 1256 articles were retrieved; 319 were considered eligible trials. Positive conclusions were reported in 56.8% of trials with industry-only, 55.6% with academia-only, 44.1% with academia and industry, 77.8% with none, and 76.4% with not described funding source (p = 0.011). Positive conclusions were reported in 60.4% of trials with unrelated COI, 60% with related COI, and 60% with no COI reported (p = 0.997). Factors that were significantly associated with the presence of positive conclusion included trials design (phase 1) [OR 11.64 (95 CI 4.66-29.09), p source [OR 2.45 (95 CI 1.22-5.22), p = 0.011]. In a multivariable regression model, all these factors remained significantly associated with trial's positive conclusion. Funding source and self-reported COI did not appear to influence the CNS trials conclusion. Funding source information and COI disclosure were under-reported in 14.1 and 17.2% of the CNS trials. Continued efforts are needed to increase rates of both COI and funding source reporting.

  1. Application of Artificial Neural Networks in the Heart Electrical Axis Position Conclusion Modeling

    Science.gov (United States)

    Bakanovskaya, L. N.

    2016-08-01

    The article touches upon building of a heart electrical axis position conclusion model using an artificial neural network. The input signals of the neural network are the values of deflections Q, R and S; and the output signal is the value of the heart electrical axis position. Training of the network is carried out by the error propagation method. The test results allow concluding that the created neural network makes a conclusion with a high degree of accuracy.

  2. Estudo sobre o melhoramento da laranja "Baía" III: Conclusão

    Directory of Open Access Journals (Sweden)

    F. G. Brieger

    1941-09-01

    -test (guadro IV and the "test of sequence" (quadro V. It was possible to separate the sample into three groups : the type "Baianinha Piracicaba" with a medium mean fruit diameter per tree, the "Baía" with large fruits and the new type "Baianinha Araras" with small fruits. 6. The experimental plot was selected as beeing reasonably uniform. The statistical analysis however revealed significant, though not very important heterogeneities which can only be partially responsible for the variations between trees mentioned above (quadro VI. 7. There is a constant negative linear correlation between the number of fruits per tree and the mean fruit diameter, the coefficient r beeing the same in all years and equal to 0.5 (quadro X. On the average, a loss of 1 mm in mean diameter corresponds to a gain of 50 fruits per tree. 8. The error within trees both when comparing the errors per tree in the same year or of different years showed significant variations which are however without much praticai importance. The annual means of these errors (sD vary from 4,69 mm in 1937 to 7,56 mm in 1939 (quadro VIII. 9. The error within trees cannot be used as a reliable measure since the variations within trees are highly abnormal, restricted by two physiological limits which prevent the appearance of very small or very large fruits and show sometimes a tendency to asymetry and bimodality. 10. The possible causes for the abnormal variation "within" were studied in some detail. The only positive result was obtained when comparing the production on older branches with that on recent strong off-shoots. In some case it was possible to collect the fruits on these components of a tree separately, the older branches forming the lower and the other the top parts of the tree (fig. 7. The latter produce always larger fruits (quadro IX and fig. 2. 11. Heterogeneity of the root stocks seems to be the most probable cause of the heterogeneity between trees. It has been shown by other experiments, not yet

  3. Removable partial dentures: clinical concepts.

    Science.gov (United States)

    Bohnenkamp, David M

    2014-01-01

    This article provides a review of the traditional clinical concepts for the design and fabrication of removable partial dentures (RPDs). Although classic theories and rules for RPD designs have been presented and should be followed, excellent clinical care for partially edentulous patients may also be achieved with computer-aided design/computer-aided manufacturing technology and unique blended designs. These nontraditional RPD designs and fabrication methods provide for improved fit, function, and esthetics by using computer-aided design software, composite resin for contours and morphology of abutment teeth, metal support structures for long edentulous spans and collapsed occlusal vertical dimensions, and flexible, nylon thermoplastic material for metal-supported clasp assemblies. Copyright © 2014 Elsevier Inc. All rights reserved.

  4. Partial scram incident in FBTR

    International Nuclear Information System (INIS)

    Usha, S.; Pillai, C.P.; Muralikrishna, G.

    1989-01-01

    Evaluation of a partial scram incident occurred at the Fast Breeder Test Reactor at Kalpakkam was carried out. Based on the observations of the experiments it was ascertained that the nonpersistant order was due to superimposed noise component on the channel that was close to the threshold and had resulted in intermittent supply to electro-magnetic (EM) coils. Owing to a larger discharge time and a smaller charge time, the EM coils got progressively discharged. It was confirmed that during the incident, partial scram took place since the charging and discharging patterns of the EM coils are dissimilar and EM coils of rods A, E and F had discharged faster than others for noise component of a particular duty cycle. However, nonlatching of scram order was because of the fact that noise pulse duration was less than latching time. (author)

  5. The marketing of partial hospitalization.

    Science.gov (United States)

    Millsap, P; Brown, E; Kiser, L; Pruitt, D

    1987-09-01

    Health-care professionals are currently operating in the context of a rapidly changing health-care delivery system, including the move away from inpatient services to outpatient services in order to control costs. Those who practice in partial-hospital settings are in a position to offer effective, cost-efficient services; however, there continue to be obstacles which hinder appropriate utilization of the modality. The development and use of a well-designed marketing plan is one strategy for removing these obstacles. This paper presents a brief overview of the marketing process, ideas for developing a marketing plan, and several examples of specific marketing strategies as well as ways to monitor their effectiveness. Partial-hospital providers must take an active role in answering the calls for alternative sources of psychiatric care. A comprehensive, education-oriented marketing approach will increase the public's awareness of such alternatives and enable programs to survive in a competitive environment.

  6. Introduction to partial differential equations

    CERN Document Server

    Borthwick, David

    2016-01-01

    This modern take on partial differential equations does not require knowledge beyond vector calculus and linear algebra. The author focuses on the most important classical partial differential equations, including conservation equations and their characteristics, the wave equation, the heat equation, function spaces, and Fourier series, drawing on tools from analysis only as they arise.Within each section the author creates a narrative that answers the five questions: (1) What is the scientific problem we are trying to understand? (2) How do we model that with PDE? (3) What techniques can we use to analyze the PDE? (4) How do those techniques apply to this equation? (5) What information or insight did we obtain by developing and analyzing the PDE? The text stresses the interplay between modeling and mathematical analysis, providing a thorough source of problems and an inspiration for the development of methods.

  7. Dynamics of partial differential equations

    CERN Document Server

    Wayne, C Eugene

    2015-01-01

    This book contains two review articles on the dynamics of partial differential equations that deal with closely related topics but can be read independently. Wayne reviews recent results on the global dynamics of the two-dimensional Navier-Stokes equations. This system exhibits stable vortex solutions: the topic of Wayne's contribution is how solutions that start from arbitrary initial conditions evolve towards stable vortices. Weinstein considers the dynamics of localized states in nonlinear Schrodinger and Gross-Pitaevskii equations that describe many optical and quantum systems. In this contribution, Weinstein reviews recent bifurcations results of solitary waves, their linear and nonlinear stability properties, and results about radiation damping where waves lose energy through radiation.   The articles, written independently, are combined into one volume to showcase the tools of dynamical systems theory at work in explaining qualitative phenomena associated with two classes of partial differential equ...

  8. Partial Cooperative Equilibria: Existence and Characterization

    Directory of Open Access Journals (Sweden)

    Amandine Ghintran

    2010-09-01

    Full Text Available We study the solution concepts of partial cooperative Cournot-Nash equilibria and partial cooperative Stackelberg equilibria. The partial cooperative Cournot-Nash equilibrium is axiomatically characterized by using notions of rationality, consistency and converse consistency with regard to reduced games. We also establish sufficient conditions for which partial cooperative Cournot-Nash equilibria and partial cooperative Stackelberg equilibria exist in supermodular games. Finally, we provide an application to strategic network formation where such solution concepts may be useful.

  9. Partial dependency parsing for Irish

    OpenAIRE

    Uí Dhonnchadha, Elaine; van Genabith, Josef

    2010-01-01

    In this paper we present a partial dependency parser for Irish, in which Constraint Grammar (CG) rules are used to annotate dependency relations and grammatical functions in unrestricted Irish text. Chunking is performed using a regular-expression grammar which operates on the dependency tagged sentences. As this is the first implementation of a parser for unrestricted Irish text (to our knowledge), there were no guidelines or precedents available. Therefore deciding what constitutes a syntac...

  10. Matching games with partial information

    Science.gov (United States)

    Laureti, Paolo; Zhang, Yi-Cheng

    2003-06-01

    We analyze different ways of pairing agents in a bipartite matching problem, with regard to its scaling properties and to the distribution of individual “satisfactions”. Then we explore the role of partial information and bounded rationality in a generalized Marriage Problem, comparing the benefits obtained by self-searching and by a matchmaker. Finally we propose a modified matching game intended to mimic the way consumers’ information makes firms to enhance the quality of their products in a competitive market.

  11. Noise suppressed partial volume correction for cardiac SPECT/CT

    Energy Technology Data Exchange (ETDEWEB)

    Chan, Chung; Liu, Chi, E-mail: chi.liu@yale.edu [Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut 06520 (United States); Liu, Hui [Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut 06520 and Key Laboratory of Particle and Radiation Imaging (Tsinghua University), Ministry of Education, Beijing 100084 (China); Grobshtein, Yariv [GE Healthcare, Haifa 3910101 (Israel); Stacy, Mitchel R. [Department of Internal Medicine, Yale University, New Haven, Connecticut 06520 (United States); Sinusas, Albert J. [Department of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut 06520 and Department of Internal Medicine, Yale University, New Haven, Connecticut 06520 (United States)

    2016-09-15

    Purpose: Partial volume correction (PVC) methods typically improve quantification at the expense of increased image noise and reduced reproducibility. In this study, the authors developed a novel voxel-based PVC method that incorporates anatomical knowledge to improve quantification while suppressing noise for cardiac SPECT/CT imaging. Methods: In the proposed method, the SPECT images were first reconstructed using anatomical-based maximum a posteriori (AMAP) with Bowsher’s prior to penalize noise while preserving boundaries. A sequential voxel-by-voxel PVC approach (Yang’s method) was then applied on the AMAP reconstruction using a template response. This template response was obtained by forward projecting a template derived from a contrast-enhanced CT image, and then reconstructed using AMAP to model the partial volume effects (PVEs) introduced by both the system resolution and the smoothing applied during reconstruction. To evaluate the proposed noise suppressed PVC (NS-PVC), the authors first simulated two types of cardiac SPECT studies: a {sup 99m}Tc-tetrofosmin myocardial perfusion scan and a {sup 99m}Tc-labeled red blood cell (RBC) scan on a dedicated cardiac multiple pinhole SPECT/CT at both high and low count levels. The authors then applied the proposed method on a canine equilibrium blood pool study following injection with {sup 99m}Tc-RBCs at different count levels by rebinning the list-mode data into shorter acquisitions. The proposed method was compared to MLEM reconstruction without PVC, two conventional PVC methods, including Yang’s method and multitarget correction (MTC) applied on the MLEM reconstruction, and AMAP reconstruction without PVC. Results: The results showed that the Yang’s method improved quantification, however, yielded increased noise and reduced reproducibility in the regions with higher activity. MTC corrected for PVE on high count data with amplified noise, although yielded the worst performance among all the methods

  12. A fallacious jar? The peculiar relation between descriptive premises and normative conclusions in neuroethics.

    Science.gov (United States)

    Wagner, Nils-Frederic; Northoff, Georg

    2015-06-01

    Ethical questions have traditionally been approached through conceptual analysis. Inspired by the rapid advance of modern brain imaging techniques, however, some ethical questions appear in a new light. For example, hotly debated trolley dilemmas have recently been studied by psychologists and neuroscientists alike, arguing that their findings can support or debunk moral intuitions that underlie those dilemmas. Resulting from the wedding of philosophy and neuroscience, neuroethics has emerged as a novel interdisciplinary field that aims at drawing conclusive relationships between neuroscientific observations and normative ethics. A major goal of neuroethics is to derive normative ethical conclusions from the investigation of neural and psychological mechanisms underlying ethical theories, as well as moral judgments and intuitions. The focus of this article is to shed light on the structure and functioning of neuroethical arguments of this sort, and to reveal particular methodological challenges that lie concealed therein. We discuss the methodological problem of how one can--or, as the case may be, cannot--validly infer normative conclusions from neuroscientific observations. Moreover, we raise the issue of how preexisting normative ethical convictions threaten to invalidate the interpretation of neuroscientific data, and thus arrive at question-begging conclusions. Nonetheless, this is not to deny that current neuroethics rightly presumes that moral considerations about actual human lives demand empirically substantiated answers. Therefore, in conclusion, we offer some preliminary reflections on how the discussed methodological challenges can be met.

  13. Acceleration toward the conclusion negotiation of bilateral nuclear cooperation agreements indispensable for globalization

    International Nuclear Information System (INIS)

    Mitsumata, Hiroki; Hattori, Takuya; Ake, Yutaka

    2011-01-01

    According to Japan's basic policies of new growth strategy, it would be one option of the economic growth to increase exports of nuclear power plant system or its equipments. However, bilateral nuclear cooperation agreements are indispensable for business activities on nuclear power. Recently signature of agreement with Jordan, agreed conclusion negotiation with Vietnam and Korea, under negotiation with India and expected negotiation with Indonesia and Malaysia. Signed agreements with Russia and Kazakhstan will be coming into effect and contribute nuclear fuel supply at export of nuclear power system. This special article consists of four expert's papers titled as (1) necessity of conclusion negotiation of nuclear cooperation agreements with several countries simultaneously and in parallel, (2) Japan's nuclear cooperation in new era, (3) desirable acceleration of conclusion negotiation of nuclear cooperation agreements and (4) insurance of nuclear fuel supply fundamental for global business activities of Japan's nuclear industries-best choice to establish cooperative relations with US and Russia. (T. Tanaka)

  14. The grand leap of the whale up the Niagara Falls: converting philosophical conclusions into policy prescriptions.

    Science.gov (United States)

    Holm, Søren

    2015-04-01

    This article analyzes a neat conjuring trick employed in bioethics, that is, the immediate conversion of a philosophical conclusion into a policy prescription, and compares it to the "grand leap of the whale up the Niagara Falls" mentioned by Benjamin Franklin. It is shown that there is no simple and easy way to achieve the conversion, by considering arguments falling under four headings: (1) reasonable disagreement about values and theories, (2) general jurisprudential arguments, (3) the differences between policymaking and philosophy, and (4) the messy world of implementation. The particular issue used to illustrate the difficulties in moving from philosophical conclusion to policy description is infanticide of healthy infants, but the analysis is general, and the conclusion that the immediate move to policy is illegitimate is quite general.

  15. Legal Nature of the Investor’s Consent to the Conclusion of the Agreement with Sub-contractor

    OpenAIRE

    Sławomir Szejna

    2013-01-01

    Author of present article presents and comments on the divergent views of doctrine and judicature concerning the legal nature of the investor’s consent to the conclusion of the agreement for subcontracting, arose from the introduction of the provisions of Article 6471 § 2 and 3 to the Polish Civil Code with Act dated 14 February 2003 amending the Act – the Civil Code and other acts. Author refers also to the joint responsibility of the investor and the contractor towards further subcontractor...

  16. N Reactor Production Assurance Program blance of plant evaluation: report of findings and conclusions

    International Nuclear Information System (INIS)

    Hurd, E.N.; Bitten, E.J.

    1985-03-01

    Fourteen tasks were identified by UNC Nuclear Industries for evaluating the life expectancy of N Reactor structures, systems and components in the Balance of Plant portion of the Production Assurance Program. A Westinghouse Hanford Company (WHC) evaluation team was assigned to each of these fourteen tasks. A uniform set of criteria was used by all teams in evaluating the problems that may be encountered during the extended plant operating lifetime. The overall conclusion is that extended life to those Balance of Plant components and systems studied can be achieved. Problems with the potential for compromising that conclusion are identified, and feasible solutions are provided

  17. Optimal conclusive teleportation of a d-dimensional two-particle unknown quantum state

    Institute of Scientific and Technical Information of China (English)

    Yang Yu-Guang; Wen Qiao-Yan; Zhu Fu-Chen

    2006-01-01

    A conclusive teleportation protocol of a d-dimensional two-particle unknown quantum state using three ddimensional particles in an arbitrary pure state is proposed. A sender teleports the unknown state conclusively to a receiver by using the positive operator valued measure(POVM) and introducing an ancillary qudit to perform the generalized Bell basis measurement. We calculate the optimal teleportation fidelity. We also discuss and analyse the reason why the information on the teleported state is lost in the course of the protocol.

  18. Benchmark exercises on PWR level-1 PSA (step 3). Analyses of accident sequence and conclusions

    International Nuclear Information System (INIS)

    Niwa, Yuji; Takahashi, Hideaki.

    1996-01-01

    The results of level 1 PSA generate fluctuations due to the assumptions based on several engineering judgements set in the stages of PSA analysis. On the purpose of the investigation of uncertainties due to assumptions, three kinds of a standard problem, what we call benchmark exercise have been set. In this report, sensitivity studies (benchmark exercise) of sequence analyses are treated and conclusions are mentioned. The treatment of inter-system dependency would generate uncertainly of PSA. In addition, as a conclusion of the PSA benchmark exercise, several findings in the sequence analysis together with previous benchmark analyses in earlier INSS Journals are treated. (author)

  19. Experimental evidence for partial spatial coherence in imaging Mueller polarimetry.

    Science.gov (United States)

    Ossikovski, Razvigor; Arteaga, Oriol; Yoo, Sang Hyuk; Garcia-Caurel, Enric; Hingerl, Kurt

    2017-11-15

    We demonstrate experimentally the validity of the partial spatial coherence formalism in Mueller polarimetry and show that, in a finite spatial resolution experiment, the measured response is obtained through convolving the theoretical one with the instrument function. The reported results are of primary importance for Mueller imaging systems.

  20. Fitting and Testing Conditional Multinormal Partial Credit Models

    Science.gov (United States)

    Hessen, David J.

    2012-01-01

    A multinormal partial credit model for factor analysis of polytomously scored items with ordered response categories is derived using an extension of the Dutch Identity (Holland in "Psychometrika" 55:5-18, 1990). In the model, latent variables are assumed to have a multivariate normal distribution conditional on unweighted sums of item…

  1. Detecting Math Anxiety with a Mixture Partial Credit Model

    Science.gov (United States)

    Ölmez, Ibrahim Burak; Cohen, Allan S.

    2017-01-01

    The purpose of this study was to investigate a new methodology for detection of differences in middle grades students' math anxiety. A mixture partial credit model analysis revealed two distinct latent classes based on homogeneities in response patterns within each latent class. Students in Class 1 had less anxiety about apprehension of math…

  2. Partial immunity in murine by immunization with a toxoplasmic DNA ...

    African Journals Online (AJOL)

    arsenal

    2012-06-12

    Jun 12, 2012 ... vaccine can be effective in partial protection against this parasite. In this study ... that mice immunized by pcROP1 with or without alum produced high Th1 immune response compared .... antigen-specific antibodies, 96-well costar plates were coated .... vaccines against some protozoa, for example, malaria,.

  3. Generic results and conclusions of re-evaluating the flooding protection in French Nuclear Power Plants

    International Nuclear Information System (INIS)

    Vial, E.; Rebour, V.; Mattei, J.; Gprbatchev, A.

    2002-01-01

    The partial flooding of the Blayais site, occurred on December 1999 has led to a large scale re-examination of the measures to prevent and limit the consequences associated with all contingencies or combinations of them, which could lead to external flooding of any of the 19 French sites, equipped with pressurized water reactors. An Action Program has been launched by Electricite de France and a methodology has been approved, consisting of: defining of principles for re-evaluating external flooding risks together with the relevant arrangements; applying the principles to each site and showing that the margins adopted are sufficient for achieving an acceptable safety level. The implementation of the program throughout all sites with PWR in France will extend to 2005

  4. Impact of Partial and complete rupture of anterior cruciate ligament on medial meniscus: A cadavaric study

    Directory of Open Access Journals (Sweden)

    Wei Jiang

    2012-01-01

    Conclusions: Similar to complete rupture, partial rupture of ACL can also trigger strain concentration on medial meniscus, especially posterior horn, which may be a more critical reason for meniscus injury associated with chronic ACL deficiency.

  5. The medical eye: Conclusions from eye tracking research on expertise development in medicine

    NARCIS (Netherlands)

    Jarodzka, Halszka; Jaarsma, Thomas; Dewhurst, Richard; Boshuizen, Els

    2013-01-01

    Jarodzka, H., Jaarsma, T., Dewhurst, R., & Boshuizen, H. P. A. (2012, October). The medical eye: Conclusions from eye tracking research on expertise development in medicine. Paper presented at the New tools and practices for seeing and learning in medicine ’12, University of Turku, Turku, Finland.

  6. Jumping to the wrong conclusions? An investigation of the mechanisms of reasoning errors in delusions.

    Science.gov (United States)

    Jolley, Suzanne; Thompson, Claire; Hurley, James; Medin, Evelina; Butler, Lucy; Bebbington, Paul; Dunn, Graham; Freeman, Daniel; Fowler, David; Kuipers, Elizabeth; Garety, Philippa

    2014-10-30

    Understanding how people with delusions arrive at false conclusions is central to the refinement of cognitive behavioural interventions. Making hasty decisions based on limited data ('jumping to conclusions', JTC) is one potential causal mechanism, but reasoning errors may also result from other processes. In this study, we investigated the correlates of reasoning errors under differing task conditions in 204 participants with schizophrenia spectrum psychosis who completed three probabilistic reasoning tasks. Psychotic symptoms, affect, and IQ were also evaluated. We found that hasty decision makers were more likely to draw false conclusions, but only 37% of their reasoning errors were consistent with the limited data they had gathered. The remainder directly contradicted all the presented evidence. Reasoning errors showed task-dependent associations with IQ, affect, and psychotic symptoms. We conclude that limited data-gathering contributes to false conclusions but is not the only mechanism involved. Delusions may also be maintained by a tendency to disregard evidence. Low IQ and emotional biases may contribute to reasoning errors in more complex situations. Cognitive strategies to reduce reasoning errors should therefore extend beyond encouragement to gather more data, and incorporate interventions focused directly on these difficulties. Copyright © 2014 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

  7. 19 CFR 210.63 - Proposed findings and conclusions and briefs.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Proposed findings and conclusions and briefs. 210.63 Section 210.63 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Temporary Relief § 210.63 Proposed findings...

  8. 19 CFR 210.40 - Proposed findings and conclusions and briefs.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Proposed findings and conclusions and briefs. 210.40 Section 210.40 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Prehearing Conferences and Hearings § 210...

  9. Conclusions and recommendations. [for problems in energy situation, air transportation, and hydrogen fuel

    Science.gov (United States)

    1973-01-01

    Conclusions and recommendations are presented for an analysis of the total energy situation; the effect of the energy problem on air transportation; and hydrogen fuel for aircraft. Properties and production costs of fuels, future prediction for energy and transportation, and economic aspects of hydrogen production are appended.

  10. 20 CFR 220.112 - Conclusions by physicians concerning the claimant's disability.

    Science.gov (United States)

    2010-04-01

    ... medically determinable physical or mental impairment which can be expected to result in death or which has... may have to consider such factors as age, education and past work experience. Such vocational factors... opinion by a treating source will be conclusive as to the medical issues of the nature and severity of a...

  11. Oklo: The fossil nuclear reactors. Physics study - Translation of chapters 6, 13 and conclusions

    Energy Technology Data Exchange (ETDEWEB)

    Naudet, R [CEA, Paris (France)

    1996-09-01

    Three parts of the 1991 book `Oklo: reacteurs nucleaires fossiles. Etude physique` have been translated in this report. The chapters bear the titles `Study of criticality`(45 p.), `Some problems with the overall functioning of the reactor zones`(45 p.) and `Conclusions` (15 p.), respectively.

  12. Oklo: The fossil nuclear reactors. Physics study - Translation of chapters 6, 13 and conclusions

    International Nuclear Information System (INIS)

    Naudet, R.

    1996-09-01

    Three parts of the 1991 book 'Oklo: reacteurs nucleaires fossiles. Etude physique' have been translated in this report. The chapters bear the titles 'Study of criticality'(45 p.), 'Some problems with the overall functioning of the reactor zones'(45 p.) and 'Conclusions' (15 p.), respectively

  13. Tritium in precipitation of Vostok (Antarctica): conclusions on the tritium latitude effect.

    Science.gov (United States)

    Hebert, Detlef

    2011-09-01

    During the Antarctic summer of 1985 near the Soviet Antarctic station Vostok, firn samples for tritium measurements were obtained down to a depth of 2.40 m. The results of the tritium measurements are presented and discussed. Based on this and other data, conclusions regarding the tritium latitude effect are derived.

  14. Synchronizing Strategies under Partial Observability

    DEFF Research Database (Denmark)

    Larsen, Kim Guldstrand; Laursen, Simon; Srba, Jiri

    2014-01-01

    Embedded devices usually share only partial information about their current configurations as the communication bandwidth can be restricted. Despite this, we may wish to bring a failed device into a given predetermined configuration. This problem, also known as resetting or synchronizing words, has...... been intensively studied for systems that do not provide any information about their configurations. In order to capture more general scenarios, we extend the existing theory of synchronizing words to synchronizing strategies, and study the synchronization, short-synchronization and subset...

  15. Partial differential equations an introduction

    CERN Document Server

    Colton, David

    2004-01-01

    Intended for a college senior or first-year graduate-level course in partial differential equations, this text offers students in mathematics, engineering, and the applied sciences a solid foundation for advanced studies in mathematics. Classical topics presented in a modern context include coverage of integral equations and basic scattering theory. This complete and accessible treatment includes a variety of examples of inverse problems arising from improperly posed applications. Exercises at the ends of chapters, many with answers, offer a clear progression in developing an understanding of

  16. Laparoscopic Partial Hepatectomy: Animal Experiments

    Directory of Open Access Journals (Sweden)

    Haruhiro Inoue

    1995-01-01

    Full Text Available As a first step in firmly establishing laparoscopic hepatectomy, we introduce a porcine model of laparoscopic partial hepatectomy. This procedure has been successfully performed under the normal-pressure or low-pressure pneumoperitoneum condition supported by the full-thickness abdominal wall lifting technique. An ultrasonic dissector combined with electrocautery, newly developed by Olympus Optical Corporation (Japan was effectively utilized in facilitating safe and smooth incisions into the liver parenchyma. Although indications for this procedure seem to be limited only to peripheral lesions and not to central lesions, clinical application of this method may be useful for some patients in the near future.

  17. Complex partial seizures: cerebellar metabolism

    Energy Technology Data Exchange (ETDEWEB)

    Theodore, W.H.; Fishbein, D.; Deitz, M.; Baldwin, P.

    1987-07-01

    We used positron emission tomography (PET) with (/sup 18/F)2-deoxyglucose to study cerebellar glucose metabolism (LCMRglu) and the effect of phenytoin (PHT) in 42 patients with complex partial seizures (CPS), and 12 normal controls. Mean +/- SD patient LCMRglu was 6.9 +/- 1.8 mg glucose/100 g/min (left = right), significantly lower than control values of 8.5 +/- 1.8 (left, p less than 0.006), and 8.3 +/- 1.6 (right, p less than 0.02). Only four patients had cerebellar atrophy on CT/MRI; cerebellar LCMRglu in these was 5.5 +/- 1.5 (p = 0.054 vs. total patient sample). Patients with unilateral temporal hypometabolism or EEG foci did not have lateralized cerebellar hypometabolism. Patients receiving phenytoin (PHT) at the time of scan and patients with less than 5 years total PHT exposure had lower LCMRglu, but the differences were not significant. There were weak inverse correlations between PHT level and cerebellar LCMRglu in patients receiving PHT (r = -0.36; 0.05 less than p less than 0.1), as well as between length of illness and LCMRglu (r = -0.22; 0.05 less than p less than 0.1). Patients with complex partial seizures have cerebellar hypometabolism that is bilateral and due only in part to the effect of PHT.

  18. [Removable partial dentures. Oral functions and types].

    Science.gov (United States)

    Creugers, N H J; de Baat, C

    2009-11-01

    A removable partial denture enables the restoration or improvement of 4 oral functions: aesthetics, mandibular stability, mastication, and speech. However, wearing a removable partial denture should not cause oral comfort to deteriorate. There are 3 types of removable partial dentures: acrylic tissue-supported dentures, dentures with cast metal frameworks en dentures with cast metal frameworks and (semi)precision attachments. Interrupted tooth arches,free-ending tooth arches, and a combination of interrupted as well as free-ending tooth arches can be restored using these dentures. Well-known disadvantages of removable partial dentures are problematic oral hygiene, negative influence on the remaining dentition and limited oral comfort. Due to the advanced possibilities of fixed tooth- or implant-supported partial dentures, whether or not free-ending, or tooth- as well as implant-supported partial dentures, the indication of removable partial dentures is restricted. Nevertheless, for the time being the demand for removable partial dentures is expected to continue.

  19. Abstract methods in partial differential equations

    CERN Document Server

    Carroll, Robert W

    2012-01-01

    Detailed, self-contained treatment examines modern abstract methods in partial differential equations, especially abstract evolution equations. Suitable for graduate students with some previous exposure to classical partial differential equations. 1969 edition.

  20. Male patients with partial androgen insensitivity syndrome

    DEFF Research Database (Denmark)

    Hellmann, Philip; Christiansen, Peter; Johannsen, Trine Holm

    2012-01-01

    To describe the natural history of phenotype, growth and gonadal function in patients with partial androgen insensitivity syndrome.......To describe the natural history of phenotype, growth and gonadal function in patients with partial androgen insensitivity syndrome....

  1. Comparative videostroboscopic analysis after different external partial laryngectomies

    Directory of Open Access Journals (Sweden)

    Mumović Gordana M.

    2014-01-01

    Full Text Available Background/Aim. After external partial laryngectomias, videostroborscopy is very usefull in evaluation of postoperative phonatory mehanisms showing the “slow motion” of the vibrations of the remaining laryngeal structures. The aim of this paper was to compare the videostroboscopic characteristics of the vibration and to establish the differences in the phonation mechanisms depending on the type of external partial laryngectomy performed. Methods. This prospective study was conducted during the period 2003-2009 at the Ear, Nose and Throat Clinic, Clinical Center of Vojvodina, Novi Sad, including 99 patients with laryngeal carcinoma, treated with open surgical approach using different types of vertical and horizontal partial laryngectomy. Videostroboscopy was used to analyse vibrations of the remaining laryngeal structures. Results. The dominant vibration structure after partial horizontal laryngectomy, chordectomy, frontolateral laryngectomy and three quarter laryngectomy was the remaining vocal fold, after hemilaryngectomy it was the false vocal fold and after subtotal and near total laryngectomy it was the arythenoid. In patients with supracricoid hemilaryngopharyngectomy performed, many different structures were involved in the vibration. After most of the partial laryngectomies, vibrations can be found in the reconstructed part of the defect. In both horizontal and vertical partial laryngectomies movements of the larynx during phonation were mostly medial, while in cricohyoidoglottopexies they were anterior-posterior. Most of the operated patients (72.7% had insufficient occlusion of the neoglottis during the phonation. Conclusion. Videostroboscopy is a useful method in examining the phonation mechanisms of reconstructed laryngeal structures after partial laryngectomy as well as in planning postoperative voice therapy.

  2. Energy 2000: effects of the program and conclusions from its evaluation

    International Nuclear Information System (INIS)

    Balthasar, A.

    2000-01-01

    The action program Energy 2000 has been continually reviewed by independent experts in view of its effects. This resulted in around 50 scientific studies between 1991 and 1999, dealing with different aspects of the program. In the book 'Energy 2000: effects of the program and conclusions from its evaluation', the results of these evaluations are summarised, and conclusions for the design of the follow-up program are drawn. The organisational frame of the program is presented and the question answered whether the determining principles of the program proved practical. Besides, the effects of state intervention, of the conflict solving groups and the voluntary actions of Energy 2000 are appraised. A separate chapter is dedicated to the evaluation strategy of the program, its implementation and the benefits of the evaluations. Propositions for the evaluation of the follow-up program are formulated as well. Dr. Andreas Balthasar is President of the Swiss Evaluation Society. (author)

  3. The 1993 Finnish Interdisciplinary Seminar on SETI - A review of aims, approaches and conclusions

    Science.gov (United States)

    Seppanen, Jouko

    1993-10-01

    The communications of the International Interdisciplinary Seminar on SETI, held on March 6-7, 1993 in Vantaa, Finland, are reviewed and the contents and conclusions of papers summarized. The seminar was organized jointly by the Finnish Artificial Intelligence Society (FAIS), Finnish Astronomical Society, Ursa Astronomical Association and Heureka - The Finnish Science Centre. As the ninth in a series of intelligence-related seminars of FAIS, SETI was chosen as the topic for spring 1993, noting the new ten year NASA SETI program HRMS (High Resolution Micro-wave Survey), commenced on Columbus Day, October 12, 1992. The aims and the interdisciplinary format of the seminar are described, the main results and conclusions of papers are restated, and the seminar publications introduced. The summaries of papers are based on their abstracts and contain excerpts from texts.

  4. Conclusions on the two technical panels on HLW-disposal and waste treatment processes respectively

    International Nuclear Information System (INIS)

    Dinkespiller, J.A.; Dejonghe, P.; Feates, F.

    1986-01-01

    The paper reports the concluding panel session at the European Community Conference on radioactive waste management and disposal, Luxembourg 1985. The panel considered the conclusions of two preceeding technical panels on high level waste (HLW) disposal and waste treatment processes. Geological disposal of HLW, waste management, safety assessment of waste disposal, public opinion, public acceptance of the manageability of radioactive wastes, international cooperation, and waste management in the United States, are all discussed. (U.K.)

  5. Chernobyl accident: causes and consequences (expert conclusion). Part 3. Chernobyl accident effect on Belarus

    International Nuclear Information System (INIS)

    Nesterenko, V.B.

    1992-01-01

    Expert conclusion is presented on the Chernobyl accident effect on Belarus. Problems of ground and food contamination, medical and biological radiation effects on the population are considered. Attention is paid to the radiation monitoring and radiometric gages. Scale of the damage for forestry and agriculture is described and recommendations on the agriculture is described and recommendations on the agricultural production and forest utilization at contaminated areas are given. 24 refs.; 4 figs.; 24 tabs

  6. Cognitive control in belief-laden reasoning during conclusion processing: An ERP study

    OpenAIRE

    Junlong Luo, Xiumin Du , Edward J. N. Stupple, Xiao Xiao, Lei Jia , Qinglin Zhang ,

    2012-01-01

    Belief-bias is the tendency to accept conclusions that are compatible with existing beliefs more frequently than those that contradict beliefs. It is one of the most replicated behavioral findings in the reasoning literature. Recently, neuroimaging studies using functional magnetic resonance imaging (fMRI) and event-related potentials (ERPs) have provided a new perspective and have demonstrated neural correlates of belief bias that have been viewed as supportive of dual process theories of be...

  7. International senior expert symposium on electricity and the environment: Highlights and conclusions from Helsinki

    International Nuclear Information System (INIS)

    Bennett, L.L.

    1991-01-01

    This article summarizes briefly the Senior Expert Symposium on Electricity and the Environment, held in May 1991. Four Expert Groups considered key issues: the implications for the global environment of energy and electricity supply and demand; energy sources and technologies for electricity generation; comparative environmental and health effects of different energy sources for electricity generation; and the incorporation of environmental and health impacts into policy, planning and decision making for the electricity sector. The conclusions of these groups are presented

  8. ANCLI's conclusions and recommendations made after the ANCLI colloquium 'Tritium, discrete, but present everywhere'

    International Nuclear Information System (INIS)

    Sene, M.

    2009-01-01

    The authors briefly state the conclusions of the colloquium about the presence of tritium in the environment, its sanitary impact, the re-examination of a management based on release, the need to reduce tritium production. The recommendations are also indicated: to continue researches on organically bound tritium, not to allow any release increase as long as effects are not better known. The role of the ANCLI is outlined

  9. Definition of sampling units begets conclusions in ecology: the case of habitats for plant communities

    OpenAIRE

    M?rsdorf, Martin A.; Ravolainen, Virve T.; St?vern, Leif Einar; Yoccoz, Nigel G.; J?nsd?ttir, Ingibj?rg Svala; Br?then, Kari Anne

    2015-01-01

    In ecology, expert knowledge on habitat characteristics is often used to define sampling units such as study sites. Ecologists are especially prone to such approaches when prior sampling frames are not accessible. Here we ask to what extent can different approaches to the definition of sampling units influence the conclusions that are drawn from an ecological study? We do this by comparing a formal versus a subjective definition of sampling units within a study design which is ...

  10. PARALLEL SOLUTION METHODS OF PARTIAL DIFFERENTIAL EQUATIONS

    Directory of Open Access Journals (Sweden)

    Korhan KARABULUT

    1998-03-01

    Full Text Available Partial differential equations arise in almost all fields of science and engineering. Computer time spent in solving partial differential equations is much more than that of in any other problem class. For this reason, partial differential equations are suitable to be solved on parallel computers that offer great computation power. In this study, parallel solution to partial differential equations with Jacobi, Gauss-Siedel, SOR (Succesive OverRelaxation and SSOR (Symmetric SOR algorithms is studied.

  11. Jumping to the wrong conclusions? An investigation of the mechanisms of reasoning errors in delusions

    Science.gov (United States)

    Jolley, Suzanne; Thompson, Claire; Hurley, James; Medin, Evelina; Butler, Lucy; Bebbington, Paul; Dunn, Graham; Freeman, Daniel; Fowler, David; Kuipers, Elizabeth; Garety, Philippa

    2014-01-01

    Understanding how people with delusions arrive at false conclusions is central to the refinement of cognitive behavioural interventions. Making hasty decisions based on limited data (‘jumping to conclusions’, JTC) is one potential causal mechanism, but reasoning errors may also result from other processes. In this study, we investigated the correlates of reasoning errors under differing task conditions in 204 participants with schizophrenia spectrum psychosis who completed three probabilistic reasoning tasks. Psychotic symptoms, affect, and IQ were also evaluated. We found that hasty decision makers were more likely to draw false conclusions, but only 37% of their reasoning errors were consistent with the limited data they had gathered. The remainder directly contradicted all the presented evidence. Reasoning errors showed task-dependent associations with IQ, affect, and psychotic symptoms. We conclude that limited data-gathering contributes to false conclusions but is not the only mechanism involved. Delusions may also be maintained by a tendency to disregard evidence. Low IQ and emotional biases may contribute to reasoning errors in more complex situations. Cognitive strategies to reduce reasoning errors should therefore extend beyond encouragement to gather more data, and incorporate interventions focused directly on these difficulties. PMID:24958065

  12. Delayed development of radiation sickness in animals following partial exposure

    International Nuclear Information System (INIS)

    Vershinina, S.F.; Markochev, A.V.

    1995-01-01

    Causes of reduction of the life span of animals after partial exposure of the head, thorax, and abdomen are analyzed. Pulmonosclerosis and cardiosclerosis were mainly responsible for animal death following partial radiation exposure of the thorax; these conditions appreciably shortened the life span of the animals. After exposure of the head deaths were due to pneumonias which negligibly reduced the duration of life. Exposure of the abdomen led to the development of diabetes mellitus which shortened the life span by half. 18 refs., 1 tab

  13. How often do sensitivity analyses for economic parameters change cost-utility analysis conclusions?

    Science.gov (United States)

    Schackman, Bruce R; Gold, Heather Taffet; Stone, Patricia W; Neumann, Peter J

    2004-01-01

    There is limited evidence about the extent to which sensitivity analysis has been used in the cost-effectiveness literature. Sensitivity analyses for health-related QOL (HR-QOL), cost and discount rate economic parameters are of particular interest because they measure the effects of methodological and estimation uncertainties. To investigate the use of sensitivity analyses in the pharmaceutical cost-utility literature in order to test whether a change in economic parameters could result in a different conclusion regarding the cost effectiveness of the intervention analysed. Cost-utility analyses of pharmaceuticals identified in a prior comprehensive audit (70 articles) were reviewed and further audited. For each base case for which sensitivity analyses were reported (n = 122), up to two sensitivity analyses for HR-QOL (n = 133), cost (n = 99), and discount rate (n = 128) were examined. Article mentions of thresholds for acceptable cost-utility ratios were recorded (total 36). Cost-utility ratios were denominated in US dollars for the year reported in each of the original articles in order to determine whether a different conclusion would have been indicated at the time the article was published. Quality ratings from the original audit for articles where sensitivity analysis results crossed the cost-utility ratio threshold above the base-case result were compared with those that did not. The most frequently mentioned cost-utility thresholds were $US20,000/QALY, $US50,000/QALY, and $US100,000/QALY. The proportions of sensitivity analyses reporting quantitative results that crossed the threshold above the base-case results (or where the sensitivity analysis result was dominated) were 31% for HR-QOL sensitivity analyses, 20% for cost-sensitivity analyses, and 15% for discount-rate sensitivity analyses. Almost half of the discount-rate sensitivity analyses did not report quantitative results. Articles that reported sensitivity analyses where results crossed the cost

  14. [Removable partial dentures. Oral functions and types

    NARCIS (Netherlands)

    Creugers, N.H.J.; Baat, C. de

    2009-01-01

    A removable partial denture enables the restoration or improvement of 4 oral functions: aesthetics, mandibular stability, mastication, and speech. However, wearing a removable partial denture should not cause oral comfort to deteriorate. There are 3 types of removable partial dentures: acrylic

  15. [Conventional retaining of removable partial dentures

    NARCIS (Netherlands)

    Keltjens, H.M.A.M.; Witter, D.J.; Creugers, N.H.J.

    2009-01-01

    Mechanical and biological criteria have to be met in retaining the metal frame of a removable partial denture. Additionally, a removable partial denture is part of the occlusal interface by the clasps and the denture teeth. With respect to mechanical aspects, all rigid parts of the removable partial

  16. Precipitation in partially stabilized zirconia

    International Nuclear Information System (INIS)

    Bansal, G.K.

    1975-01-01

    Transmission electron microscopy was used to study the substructure of partially stabilized ZrO 2 (PSZ) samples, i.e., 2-phase systems containing both cubic and monoclinic modifications of zirconia, after various heat treatments. Monoclinic ZrO 2 exists as (1) isolated grains within the polycrystalline aggregate (a grain- boundary phase) and (2) small plate-like particles within cubic grains. These intragranular precipitates are believed to contribute to the useful properties of PSZ via a form of precipitation hardening. These precipitates initially form as tetragonal ZrO 2 , with a habit plane parallel to the brace 100 brace matrix planes. The orientation relations between the tetragonal precipitates and the cubic matrix are brace 100 brace/sub matrix/ 2 parallel brace 100 brace /sub precipitate/ or (001)/sub precipitate/ and broken bracket 100 broken bracket/sub matrix/ 2 parallel broken bracket 100 broken bracket/sub precipitate/ or [001]/sub precipitate/. (U.S.)

  17. Partially coherent isodiffracting pulsed beams

    Science.gov (United States)

    Koivurova, Matias; Ding, Chaoliang; Turunen, Jari; Pan, Liuzhan

    2018-02-01

    We investigate a class of isodiffracting pulsed beams, which are superpositions of transverse modes supported by spherical-mirror laser resonators. By employing modal weights that, for stationary light, produce a Gaussian Schell-model beam, we extend this standard model to pulsed beams. We first construct the two-frequency cross-spectral density function that characterizes the spatial coherence in the space-frequency domain. By assuming a power-exponential spectral profile, we then employ the generalized Wiener-Khintchine theorem for nonstationary light to derive the two-time mutual coherence function that describes the space-time coherence of the ensuing beams. The isodiffracting nature of the laser resonator modes permits all (paraxial-domain) calculations at any propagation distance to be performed analytically. Significant spatiotemporal coupling is revealed in subcycle, single-cycle, and few-cycle domains, where the partial spatial coherence also leads to reduced temporal coherence even though full spectral coherence is assumed.

  18. CONCLUSION It is obvious that a diagnosis of breast cancer causes ...

    African Journals Online (AJOL)

    Sitwala

    Hack, T.F. and Degner, L.F. Coping responses following breast cancer diagnosis predict psychological adjustment three years later. Journal of Psychoncology 2004; 13 (4): 235-. 247. 15. Zakowski, S., Hall, A., Klein, L. and Baum, A. Appraised control, coping and stress in a community Sample. A test of the goodness-of-fit.

  19. Workshop on iodine aspects of severe accident management. Summary and conclusions

    International Nuclear Information System (INIS)

    2000-03-01

    Following a recommendation of the OECD Workshop on the Chemistry of Iodine in Reactor Safety held in Wuerenlingen (Switzerland) in June 1996 [Summary and Conclusions of the Workshop, Report NEA/CSNI/R(96)7], the CSNI decided to sponsor a Workshop on Iodine Aspects of Severe Accident Management, and their planned or effective implementation. The starting point for this conclusion was the realization that the consolidation of the accumulated iodine chemistry knowledge into accident management guidelines and procedures remained, to a large extent, to be done. The purpose of the meeting was therefore to help build a bridge between iodine research and the application of its results in nuclear power plants, with particular emphasis on severe accident management. Specifically, the Workshop was expected to answer the following questions: - what is the role of iodine in severe accident management? - what are the needs of the utilities? - how can research fulfill these needs? The Workshop was organized in Vantaa (Helsinki), Finland, from 18 to 20 May 1999, in collaboration with Fortum Engineering Ltd. It was attended by forty-six specialists representing fifteen Member countries and the European Commission. Twenty-eight papers were presented. These included four utility papers, representing the views of Electricite de France (EDF), Teollisuuden Voima Oy and Fortum Engineering Ltd (Finland), the Nuclear Energy Institute (USA), and Japanese utilities. The papers were presented in five sessions: - iodine speciation; - organic compound control; - iodine control; - modeling; - iodine management; A sixth session was devoted to a general discussion on iodine management under severe accident conditions. This report summarizes the content of the papers and the conclusions of the workshop

  20. Specialist meeting on selected containment severe accident management strategies. Summary and conclusions

    International Nuclear Information System (INIS)

    1994-01-01

    The CSNI Specialist Meeting on Selected Containment Severe Accident Management Strategies held in Stockholm, Sweden in June 1994 was organised by the Task Group on Containment Aspects of Severe Accident Management (CAM) of CSNI's Principal Working Group on the Confinement of Accidental Radioactive Releases (PWG4) in collaboration with the Swedish Nuclear Power Inspectorate (SKI). Conclusions and recommendations are given for each of the sessions of the workshops: Containment accident management strategies (general aspects); hydrogen management techniques and other containment accident management techniques; surveillance and protection of containment function

  1. Some conclusions about the concrete strength of the bored piles of Angra 2 nuclear power plant

    International Nuclear Information System (INIS)

    Thomaz, E.C.S.; Joia, L.A.

    1984-01-01

    The concrete of the bored piles of Angra 2 was submitted to a deep control, so more than five thousand core samples were analyzed to verify the quality of the concrete. Based on these samples and using statistics regression theory some conclusions could be done. It was analyzed the dependence of the concrete strength upon the depth of the pile. Also based on these samples some probability distribution functions that could simulate the concrete strength were studied applying the Kolmogorov - Smirnov fitness test. Finally, a method for evaluating a confidence interval of one of the probability function (Weibull distribution) was developed adopting the Monte Carlo simulation technique. (Author) [pt

  2. One metric does not tell the whole story of scientific production. III. Management and conclusions

    Directory of Open Access Journals (Sweden)

    Nieves GONZÁLEZ-FERNÁNDEZ-VILLAVICENCIO

    2016-09-01

    Full Text Available Introduction: There are different strategies for scientific publication that can be addressed from the perspective of management, ahead of the assessment by national agencies. Rising of alternative metrics, services and suppliers. Method: Narrative review. Results: the characteristic features of the evaluation criteria of scientific publications by Spanish agencies evaluation are presented and described altmetrics services. Conclusions: The need for national evaluation systems of scientific production to avoid the current bias and ignorance of the publishing sector which suffer WoS and Scopus arises. And also the need for other altmetric systems, complementary to traditional, to expand the type of scientific products and evaluate the scientific social impact.

  3. The successful conclusion of the Deep Space 1 Mission: important results without a flashy title

    Science.gov (United States)

    Rayman, M. D.

    2002-01-01

    In September 2001, Deep Space 1 (DS1) completed a high-risk and flawless encounter with comet 19P/Borrelly. Its data provide a detailed view of this comet and offere surprising and exciting insights. With this successful conclusion of its extended mission, DS1 undertook a hyperextended mission. Following this period of extremely agressive testing, with no further technology or science objectives, the mission was terminated on December 18, 2001, with the powering off of the spacecraft's trnasmitter, although the receiver was left on. By the end of its mission, DS1 had returned a wealth of important science data and engineering data for future missions.

  4. Epidemiology, biology and therapy of Merkel cell carcinoma: conclusions from the EU project IMMOMEC

    DEFF Research Database (Denmark)

    Becker, Juergen C.; Stang, Andreas; zur Hausen, Axel

    2018-01-01

    Merkel cell carcinoma (MCC) is a highly aggressive, often lethal neuroendocrine cancer. Its carcinogenesis may be either caused by the clonal integration of the Merkel cell polyomavirus into the host genome or by UV-induced mutations. Notably, virally-encoded oncoproteins and UV-induced mutations...... knowledge on epidemiology, biology and therapy of MCC as conclusion of the project 'Immune Modulating strategies for treatment of Merkel Cell Carcinoma', which was funded over a 5-year period by the European Commission to investigate innovative immunotherapies for MCC....

  5. Partial mortality in massive reef corals as an indicator of sediment stress on coral reefs

    International Nuclear Information System (INIS)

    Nugues, Maggy M.; Roberts, Callum M.

    2003-01-01

    Partial mortality and fission on colonies of four common massive coral species were examined at sites differing in their exposure to river sediments in St. Lucia, West Indies. Rates of partial mortality were higher close to the river mouths, where more sediments were deposited, than away from the rivers in two coral species. Frequency of fission showed no significant trend. The percent change in coral cover on reefs from 1995 to 1998 was negatively related to the rate of partial mortality estimated in 1998 in all species. This suggests that partial mortality rates could reflect longer-term temporal changes in coral communities. Similar conclusions could also be reached using a less precise measure and simply recording partial mortality on colonies as <50% and ≥50% dead tissue. We conclude that partial mortality in some species of massive reef corals, expressed as the amount of dead tissue per colony, could provide a rapid and effective means of detecting sediment stress on coral reefs

  6. Partial mortality in massive reef corals as an indicator of sediment stress on coral reefs

    Energy Technology Data Exchange (ETDEWEB)

    Nugues, Maggy M.; Roberts, Callum M

    2003-03-01

    Partial mortality and fission on colonies of four common massive coral species were examined at sites differing in their exposure to river sediments in St. Lucia, West Indies. Rates of partial mortality were higher close to the river mouths, where more sediments were deposited, than away from the rivers in two coral species. Frequency of fission showed no significant trend. The percent change in coral cover on reefs from 1995 to 1998 was negatively related to the rate of partial mortality estimated in 1998 in all species. This suggests that partial mortality rates could reflect longer-term temporal changes in coral communities. Similar conclusions could also be reached using a less precise measure and simply recording partial mortality on colonies as <50% and {>=}50% dead tissue. We conclude that partial mortality in some species of massive reef corals, expressed as the amount of dead tissue per colony, could provide a rapid and effective means of detecting sediment stress on coral reefs.

  7. The prospects for nuclear power in the UK. Conclusions of the Government's nuclear review

    International Nuclear Information System (INIS)

    1995-05-01

    The conclusions of the United Kingdom government's review of the nuclear industry in Britain were presented to Parliament in May 1995. The provision of public sector support for a new nuclear power station is deemed unwarranted against the background of the current electricity market. In reaching this conclusion the government considered possible environmental and strategic advantages, the question of diversity of fuel sources, and wider economic benefits. It is intended to privatize parts of Nuclear Electric and Scottish Nuclear in 1996 as subsidiaries of a single holding company to take over the UK's AGR and PWR stations together with a significant level of their associated liabilities. A publicly owned company will continue to run the magnox stations and retain their liabilities. British Nuclear Fuels Ltd (BNFL) will continue to offer nuclear fuel services and to receive government support in developing business in overseas markets. Since their formation in 1990, Nuclear Electric and Scottish Nuclear have improved their financial performance significantly. At privatisation the nuclear component of the fossil fuel levy will cease to be paid to Nuclear Electric and Scottish Nuclear will no longer receive the current premium price paid under the Nuclear Energy Agreement. The current regulatory regime and rigorous safety standards for nuclear power will remain substantially unchanged. (UK)

  8. Comparative analysis of sustainable consumption and production in Visegrad region - conclusions for textile and clothing sector

    Science.gov (United States)

    Koszewska, M.; Militki, J.; Mizsey, P.; Benda-Prokeinova, R.

    2017-10-01

    Gradual environmental degradation, shrinking of non-renewable resources, and lower quality of life are directly or indirectly arising from snowballing consumption. These unfavorable processes concern increasingly textile and clothing sector and are increasingly being felt in Visegrad Region (V4). The objective of the article was to access current consumption patterns in V4 countries, identify the factors that influence those patterns and finally to draw the conclusions for more sustainable consumption and production models as well as to make a comparative analysis of the results across V4 countries. A consumer survey was conducted to examine V4 citizens’ attitudes and behaviors in the context of sustainable consumption. To ensure sample size and comparability across countries 2000 randomly-selected V4 citizens, aged 18 and over, were interviewed. To analyze the supply side of the market and legal framework, the desk research was used. The results allowed to give some guidelines for the joint V4 strategy for solving ecological and social problems of V4 countries as well as the conclusions for textile and clothing sector.

  9. [Sexual child abuse: correlation between medical certificates' conclusions and judiciary sanctions].

    Science.gov (United States)

    Soumah, M M; Bah, H; Mbaye, I; Fall, M C; Yetognon, C; Sow, M L

    2005-01-01

    Sexual child abuse, comprises of indecency attitudes and physical misbehaviours, directed towards children are dominated by rape. The objective of our study was to assess in sexual child abuse the relation between the conclusion of medical certificates and court decision. It is a retrospective study carried out from 1994 to 1998 on the clerk's office correctional repertories in Dakar regional court. An overall number of 79 cases of child abuse were collected in 5 years period. Children under 18 years old of of both sex, were concerned. Data found were correlated with a review of requisition cases received by the of gynaecology and obstetrics clinic of Aristide Dantec Hospital. This facilitates the establishement of the relationship between the offences and the pronounced sanctions, as well as the initial medical certificate and these sanctions. The sanctions were severe whenever rape had been retained. Some cases were disqualified in indecent assault and were judged as such. The judge decision, which follow the medical certificate conclusions in 11 cases out of 14 shows the importance and reliability of this medical document. All files reviewed at the medical and legal level were incomplete. The difficulty of the materiality of the rape and the psychological consequences in the long run and especially HIV infection should invite to a multidisciplinary, specialized and organized management of sexual child abuse. This study has shown the importance of a correct and complete drafting of the medical certificate, to enable the establishment by the judge the materiality of the facts.

  10. Attaining and Maintaining a Continuity of Knowledge to Draw Safeguards Conclusions with Confidence.

    Energy Technology Data Exchange (ETDEWEB)

    Bean, Robert [Purdue Univ., West Lafayette, IN (United States); Blair, Dianna S. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Pickett, Chris [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2014-11-01

    As the 21st century progresses, new nuclear facilities and the expansion of nuclear activities into new countries will require the International Atomic Energy Agency (IAEA) to place a higher reliance on attaining and maintaining a Continuity of Knowledge (CoK) of its safeguards information than is currently practiced. Additionally, a conceptual view of where and how CoK can be applied will need to evolve to support improved efficiency and efficacy of drawing a safeguards conclusion for each Member State. The ability to draw a safeguards conclusion for a Member State will be predicated on the confidence that CoK has been attained and subsequently maintained with respect to the data and information streams used by the IAEA. This confidence can be described as a function of factors such as elapsed time since the measurement, surveillance of attributes, authentication of information, historic knowledge of potential system failures, and the number and type of data collections. A set of general scenarios are further described for determining what is required to attain CoK and whether CoK has been maintained. A high-level analysis of example scenarios is presented to identify failures or gaps that could cause a loss of CoK. Potential areas for technological research and development are discussed for the next generation of CoK tools.

  11. Partial dynamical systems, fell bundles and applications

    CERN Document Server

    Exel, Ruy

    2017-01-01

    Partial dynamical systems, originally developed as a tool to study algebras of operators in Hilbert spaces, has recently become an important branch of algebra. Its most powerful results allow for understanding structural properties of algebras, both in the purely algebraic and in the C*-contexts, in terms of the dynamical properties of certain systems which are often hiding behind algebraic structures. The first indication that the study of an algebra using partial dynamical systems may be helpful is the presence of a grading. While the usual theory of graded algebras often requires gradings to be saturated, the theory of partial dynamical systems is especially well suited to treat nonsaturated graded algebras which are in fact the source of the notion of "partiality". One of the main results of the book states that every graded algebra satisfying suitable conditions may be reconstructed from a partial dynamical system via a process called the partial crossed product. Running in parallel with partial dynamica...

  12. Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia☆☆☆

    Science.gov (United States)

    Englum, Brian R.; Rothman, Jennifer; Leonard, Sarah; Reiter, Audra; Thornburg, Courtney; Brindle, Mary; Wright, Nicola; Heeney, Matthew M.; Smithers, C. Jason; Brown, Rebeccah L.; Kalfa, Theodosia; Langer, Jacob C.; Cada, Michaela; Oldham, Keith T.; Scott, J. Paul; St Peter, Shawn D; Sharma, Mukta; Davidoff, Andrew M.; Nottage, Kerri; Bernabe, Kathryn; Wilson, David B.; Dutta, Sanjeev; Glader, Bertil; Crary, Shelley E.; Dassinger, Melvin S.; Dunbar, Levette; Islam, Saleem; Kumar, Manjusha; Rescorla, Fred; Bruch, Steve; Campbell, Andrew; Austin, Mary; Sidonio, Robert; Blakely, Martin L.; Rice, Henry E.

    2016-01-01

    Purpose The purpose of this study was to define the hematologic response to total splenectomy (TS) or partial splenectomy (PS) in children with hereditary spherocytosis (HS) or sickle cell disease (SCD). Methods The Splenectomy in Congenital Hemolytic Anemia (SICHA) consortium registry collected hematologic outcomes of children with CHA undergoing TS or PS to 1 year after surgery. Using random effects mixed modeling, we evaluated the association of operative type with change in hemoglobin, reticulocyte counts, and bilirubin. We also compared laparoscopic to open splenectomy. Results The analysis included 130 children, with 62.3% (n = 81) undergoing TS. For children with HS, all hematologic measures improved after TS, including a 4.1 g/dl increase in hemoglobin. Hematologic parameters also improved after PS, although the response was less robust (hemoglobin increase 2.4 g/dl, p < 0.001). For children with SCD, there was no change in hemoglobin. Laparoscopy was not associated with differences in hematologic outcomes compared to open. TS and laparoscopy were associated with shorter length of stay. Conclusion Children with HS have an excellent hematologic response after TS or PS, although the hematologic response is more robust following TS. Children with SCD have smaller changes in their hematologic parameters. These data offer guidance to families and clinicians considering TS or PS. PMID:26613837

  13. Identification of PPARgamma partial agonists of natural origin (II: in silico prediction in natural extracts with known antidiabetic activity.

    Directory of Open Access Journals (Sweden)

    Laura Guasch

    Full Text Available BACKGROUND: Natural extracts have played an important role in the prevention and treatment of diseases and are important sources for drug discovery. However, to be effectively used in these processes, natural extracts must be characterized through the identification of their active compounds and their modes of action. METHODOLOGY/PRINCIPAL FINDINGS: From an initial set of 29,779 natural products that are annotated with their natural source and using a previously developed virtual screening procedure (carefully validated experimentally, we have predicted as potential peroxisome proliferators-activated receptor gamma (PPARγ partial agonists 12 molecules from 11 extracts known to have antidiabetic activity. Six of these molecules are similar to molecules with described antidiabetic activity but whose mechanism of action is unknown. Therefore, it is plausible that these 12 molecules could be the bioactive molecules responsible, at least in part, for the antidiabetic activity of the extracts containing them. In addition, we have also identified as potential PPARγ partial agonists 10 molecules from 16 plants with undescribed antidiabetic activity but that are related (i.e., they are from the same genus to plants with known antidiabetic properties. None of the 22 molecules that we predict as PPARγ partial agonists show chemical similarity with a group of 211 known PPARγ partial agonists obtained from the literature. CONCLUSIONS/SIGNIFICANCE: Our results provide a new hypothesis about the active molecules of natural extracts with antidiabetic properties and their mode of action. We also suggest plants with undescribed antidiabetic activity that may contain PPARγ partial agonists. These plants represent a new source of potential antidiabetic extracts. Consequently, our work opens the door to the discovery of new antidiabetic extracts and molecules that can be of use, for instance, in the design of new antidiabetic drugs or functional foods focused

  14. Natural variation in partial resistance to Pseudomonas syringae is controlled by two major QTLs in Arabidopsis thaliana.

    Directory of Open Access Journals (Sweden)

    Laure Perchepied

    Full Text Available BACKGROUND: Low-level, partial resistance is pre-eminent in natural populations, however, the mechanisms underlying this form of resistance are still poorly understood. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we used the model pathosystem Pseudomonas syringae pv. tomato DC3000 (Pst - Arabidopsis thaliana to study the genetic basis of this form of resistance. Phenotypic analysis of a set of Arabidopsis accessions, based on evaluation of in planta pathogen growth revealed extensive quantitative variation for partial resistance to Pst. It allowed choosing a recombinant inbred line (RIL population derived from a cross between the accessions Bayreuth and Shahdara for quantitative genetic analysis. Experiments performed under two different environmental conditions led to the detection of two major and two minor quantitative trait loci (QTLs governing partial resistance to Pst and called PRP-Ps1 to PRP-Ps4. The two major QTLs, PRP-Ps1 and PRP-Ps2, were confirmed in near isogenic lines (NILs, following the heterogeneous inbred families (HIFs strategy. Analysis of marker gene expression using these HIFs indicated a negative correlation between the induced amount of transcripts of SA-dependent genes PR1, ICS and PR5, and the in planta bacterial growth in the HIF segregating at PRP-Ps2 locus, suggesting an implication of PRP-Ps2 in the activation of SA dependent responses. CONCLUSIONS/SIGNIFICANCE: These results show that variation in partial resistance to Pst in Arabidopsis is governed by relatively few loci, and the validation of two major loci opens the way for their fine mapping and their cloning, which will improve our understanding of the molecular mechanisms underlying partial resistance.

  15. Partially wedged beams improve radiotherapy treatment of urinary bladder cancer

    International Nuclear Information System (INIS)

    Muren, Ludvig Paul; Hafslund, Rune; Gustafsson, Anders; Smaaland, Rune; Dahl, Olav

    2001-01-01

    Background and purpose: Partially wedged beams (PWBs) having wedge in one part of the field only, can be shaped using dynamic jaw intensity modulation. The possible clinical benefit of PWBs was tested in treatment plans for muscle-infiltrating bladder cancer. Material and methods: Three-dimensional treatment plans for 25 bladder cancer patients were analyzed. The originally prescribed standard conformal four-field box technique, which includes the use of lateral ordinary wedge beams, was compared to a modified conformal treatment using customized lateral PWBs. In these modified treatment plans, only the anterior parts of the two lateral beams had a wedge. To analyze the potential clinical benefit of treatment with PWBs, treatment plans were scored and compared using both physical parameters and biological dose response models. One tumour control probability model and two normal tissue complication probability (NTCP) models were applied. Different parameters for normal tissue radiation tolerance presented in the literature were used. Results: By PWBs the dose homogeneity throughout the target volume was improved for all patients, reducing the average relative standard deviation of the target dose distribution from 2.3 to 1.8%. A consistent reduction in the maximum doses to surrounding normal tissue volumes was also found. The most notable improvement was demonstrated in the rectum where the volume receiving more than the prescribed tumour dose was halved. Treatment with PWBs would permit a target dose escalation of 2-6 Gy in several of the patients analyzed, without increasing the overall risk for complications. The number of patients suitable for dose escalation ranged from 3 to 15, depending on whether support from all or only one of the five applied NTCP model/parameter combinations were required in each case to recommend dose escalation. Conclusion: PWBs represent a simple dose conformation tool that may allow radiation dose escalation in the treatment of muscle

  16. Enhancing efficient functioning of the nordic electricity market. Summary and conclusions

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2005-02-01

    In September 2004, Nordic Council of Ministers (NCM) in their meeting in Akureyri, Iceland, assessed the state of the Nordic electricity market. The Ministers acknowledged that the market has proved it is well functioning in many respects, however, further development of the Nordic electricity market is needed, i.e. towards a regional market without borders. The Nordic Transmission System Operators (TSOs) were asked to study how a further co-ordination of the system responsibility, a joint organizing and financing of the grid investments and a handling of peak load situations can be established in the Nordic countries. In this report, the main focus is on market-related tasks within system responsibility that are market-related and may have an effect on the functioning of the market. The report covers the following issues: definition of the system responsibility and role of TSOs, harmonization of operational rules and practices in order to improve functioning of the market, TSOs' collaboration in disturbances and shortage situations and joint Nordic transmission investments. Furthermore, the report summarizes the concrete actions taken by the TSOs in strengthening of the market mechanisms in peak load situations. (BA)

  17. Enhancing efficient functioning of the nordic electricity market. Summary and conclusions

    International Nuclear Information System (INIS)

    2005-02-01

    In September 2004, Nordic Council of Ministers (NCM) in their meeting in Akureyri, Iceland, assessed the state of the Nordic electricity market. The Ministers acknowledged that the market has proved it is well functioning in many respects, however, further development of the Nordic electricity market is needed, i.e. towards a regional market without borders. The Nordic Transmission System Operators (TSOs) were asked to study how a further co-ordination of the system responsibility, a joint organizing and financing of the grid investments and a handling of peak load situations can be established in the Nordic countries. In this report, the main focus is on market-related tasks within system responsibility that are market-related and may have an effect on the functioning of the market. The report covers the following issues: definition of the system responsibility and role of TSOs, harmonization of operational rules and practices in order to improve functioning of the market, TSOs' collaboration in disturbances and shortage situations and joint Nordic transmission investments. Furthermore, the report summarizes the concrete actions taken by the TSOs in strengthening of the market mechanisms in peak load situations. (BA)

  18. Analysing and exemplifying forensic conclusion criteria in terms of Bayesian decision theory.

    Science.gov (United States)

    Biedermann, A; Bozza, S; Taroni, F

    2018-03-01

    There is ongoing discussion in forensic science and the law about the nature of the conclusions reached based on scientific evidence, and on how such conclusions - and conclusion criteria - may be justified by rational argument. Examples, among others, are encountered in fields such as fingermarks (e.g., 'this fingermark comes from Mr. A's left thumb'), handwriting examinations (e.g., 'the questioned signature is that of Mr. A'), kinship analyses (e.g., 'Mr. A is the father of child C') or anthropology (e.g., 'these are human remains'). Considerable developments using formal methods of reasoning based on, for example (Bayesian) decision theory, are available in literature, but currently such reference principles are not explicitly used in operational forensic reporting and ensuing decision-making. Moreover, applied examples, illustrating the principles, are scarce. A potential consequence of this in practical proceedings, and hence a cause of concern, is that underlying ingredients of decision criteria (such as losses quantifying the undesirability of adverse decision consequences), are not properly dealt with. There is merit, thus, in pursuing the study and discussion of practical examples, demonstrating that formal decision-theoretic principles are not merely conceptual considerations. Actually, these principles can be shown to underpin practical decision-making procedures and existing legal decision criteria, though often not explicitly apparent as such. In this paper, we will present such examples and discuss their properties from a Bayesian decision-theoretic perspective. We will argue that these are essential concepts for an informed discourse on decision-making across forensic disciplines and the development of a coherent view on this topic. We will also emphasize that these principles are of normative nature in the sense that they provide standards against which actual judgment and decision-making may be compared. Most importantly, these standards are

  19. Stepwise Analysis of Differential Item Functioning Based on Multiple-Group Partial Credit Model.

    Science.gov (United States)

    Muraki, Eiji

    1999-01-01

    Extended an Item Response Theory (IRT) method for detection of differential item functioning to the partial credit model and applied the method to simulated data using a stepwise procedure. Then applied the stepwise DIF analysis based on the multiple-group partial credit model to writing trend data from the National Assessment of Educational…

  20. Status of maintenance in the US nuclear power industry 1985. Volume 1. Findings and conclusions

    International Nuclear Information System (INIS)

    1986-06-01

    This report presents the findings, conclusions and recommendations derived from activities performed under Phase I of the NRC Maintenance and Surveillance Program (MSP). Findings are based on trends and patterns derived from operational data compiled by the NRC for the period 1980 through 1985, site surveys conducted at eight plants, and questionnaires administered to NRC Resident Inspectors to characterize nuclear power plant maintenance programs and practices. These activities have shown that plant maintenance programs and practices are highly variable from plant-to-plant and are currently undergoing major changes. While measured plant performance has improved overall since 1980, the maintenance-related contribution to reportable events and challenges to safety systems remains high and is increasing by some measures. The findings of Phase I of the MSP confirmed a number of problems in nuclear power plant maintenance which warrant further NRC and industry attention

  1. The international INTRAVAL project. Summary and conclusions by the TVO/VTT Team

    International Nuclear Information System (INIS)

    Hautojaervi, A.

    1994-12-01

    Teollisuuden Voima Oy (TVO) participated the international cooperation project INTRAVAL and VTT Energy acted as a project team. The Finnish participation focused on flow and transport in crystalline fractured rock and six test cases out of thirteen were tackled. The experimental results were evaluated mainly by means of analytical transport models. The report presents a short review of the experience obtained in the course of the project. It concentrates on the issues revealed in the discussions and analyses of the six test cases in which the TVO/VTT team actively participated but some of the conclusions are even more general in nature. Some suggestions are made for future experimental and theoretical work in the field of geosphere. (15 refs., 2 tabs.)

  2. Conclusive evidence of abrupt coagulation inside the void during cyclic nanoparticle formation in reactive plasma

    International Nuclear Information System (INIS)

    Wetering, F. M. J. H. van de; Nijdam, S.; Beckers, J.

    2016-01-01

    In this letter, we present scanning electron microscopy (SEM) results that confirm in a direct way our earlier explanation of an abrupt coagulation event as the cause for the void hiccup. In a recent paper, we reported on the fast and interrupted expansion of voids in a reactive dusty argon–acetylene plasma. The voids appeared one after the other, each showing a peculiar, though reproducible, behavior of successive periods of fast expansion, abrupt contraction, and continued expansion. The abrupt contraction was termed “hiccup” and was related to collective coagulation of a new generation of nanoparticles growing in the void using relatively indirect methods: electron density measurements and optical emission spectroscopy. In this letter, we present conclusive evidence using SEM of particles collected at different moments in time spanning several growth cycles, which enables us to follow the nanoparticle formation process in great detail.

  3. Gasification of waste. Summary and conclusions of twenty-five years of development

    Energy Technology Data Exchange (ETDEWEB)

    Rensfelt, Erik [TPS Termiska Processer AB, Nykoeping (Sweden); Oestman, Anders [Kemiinformation AB, Stockholm (Sweden)

    2000-04-01

    An overview of nearly thirty years development of waste gasification and pyrolysis technology is given, and some major general conclusions are drawn. The aim has been to give new developers an overview of earlier major attempts to treat MSW/RDF with thermochemical processes, gasification or pyrolysis. Research work in general is not covered, only R and D efforts that have led to substantial testing in pilot scale or demonstration. For further details, especially related to ongoing R and D, readers are referred to other recent reviews. The authors' view is that gasification of RDF with appropriate gas cleaning can play an important role in the future, for environmentally acceptable and efficient energy production. A prerequisite is that some of the major mistakes can be avoided, such as: (1) too rapid scale-up without experimental base, (2) unsuitable pretreatment of MSW to RDF and poor integration with material recycling, and (3) too limited gas/flue gas cleaning.

  4. No Conclusive Evidence for Transits of Proxima b in MOST Photometry

    Energy Technology Data Exchange (ETDEWEB)

    Kipping, David M.; Chen, Jingjing; Sandford, Emily [Department of Astronomy, Columbia University, 550 W. 120th Street, New York, NY 10027 (United States); Cameron, Chris [Department of Mathematics, Physics and Geology, Cape Breton University, 1250 Grand Lake Road, Sydney, NS B1P 6L2 (Canada); Hartman, Joel D.; Bakos, Gáspár Á.; Penev, Kaloyan; Csubry, Zoltan [Department of Astrophysical Sciences, 4 Ivy Lane, Princeton, NJ 08544 (United States); Davenport, James R. A. [Department of Physics and Astronomy, Western Washington University, 516 High Street, Bellingham, WA 98225 (United States); Matthews, Jaymie M. [Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, Vancouver, BC V6T 1Z1 (Canada); Sasselov, Dimitar [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Rowe, Jason [Observatoire Astronomque du Mont Mégantic, Départment de Physique, Université de Montréal C. P. 6128, Succursale, Centre-Ville, Montréal, QC H3C 3J7 (Canada); Siverd, Robert J. [Las Cumbres Observatory Global Telescope Network, 6740 Cortona Drive, Suite 102, Santa Barbara, CA 93117 (United States); Jordán, Andrés [Instituto de Astrofísica, Universidad Católica de Chile, Av. Vicuña Mackenna 4860, 7820436 Macul, Santiago (Chile); Bayliss, Daniel [Observatoire Astronomique de Universite de Genéve, 51 ch. des Maillettes, 1290 Versoix (Switzerland); Henning, Thomas; Mancini, Luigi [Max Plank Institute for Astronomy, Königstuhl 17, D-69117 Heidelberg (Germany); and others

    2017-03-01

    The analysis of Proxima Centauri’s radial velocities recently led Anglada-Escudé et al. to claim the presence of a low-mass planet orbiting the Sun’s nearest star once every 11.2 days. Although the a priori probability that Proxima b transits its parent star is just 1.5%, the potential impact of such a discovery would be considerable. Independent of recent radial velocity efforts, we observed Proxima Centauri for 12.5 days in 2014 and 31 days in 2015 with the Microwave and Oscillations of Stars space telescope. We report here that we cannot make a compelling case that Proxima b transits in our precise photometric time series. Imposing an informative prior on the period and phase, we do detect a candidate signal with the expected depth. However, perturbing the phase prior across 100 evenly spaced intervals reveals one strong false positive and one weaker instance. We estimate a false-positive rate of at least a few percent and a much higher false-negative rate of 20%–40%, likely caused by the very high flare rate of Proxima Centauri. Comparing our candidate signal to HATSouth ground-based photometry reveals that the signal is somewhat, but not conclusively, disfavored (1 σ –2 σ ), leading us to argue that the signal is most likely spurious. We expect that infrared photometric follow-up could more conclusively test the existence of this candidate signal, owing to the suppression of flare activity and the impressive infrared brightness of the parent star.

  5. The 2015 Dietary Guidelines Advisory Committee Scientific Report: Development and Major Conclusions.

    Science.gov (United States)

    Millen, Barbara E; Abrams, Steve; Adams-Campbell, Lucile; Anderson, Cheryl Am; Brenna, J Thomas; Campbell, Wayne W; Clinton, Steven; Hu, Frank; Nelson, Miriam; Neuhouser, Marian L; Perez-Escamilla, Rafael; Siega-Riz, Anna Maria; Story, Mary; Lichtenstein, Alice H

    2016-05-01

    The Dietary Guidelines for Americans (DGA) is published every 5 y jointly by the Department of Health and Human Services (HHS) and the USDA and provides a framework for US-based food and nutrition programs, health promotion and disease prevention initiatives, and research priorities. Summarized in this report are the methods, major conclusions, and recommendations of the Scientific Report of the 2015 US Dietary Guidelines Advisory Committee (DGAC). Early in the process, the DGAC developed a conceptual model and formulated questions to examine nutritional risk and determinants and impact of dietary patterns in relation to numerous health outcomes among individuals aged ≥2 y. As detailed in the report, an expansive, transparent, and comprehensive process was used to address each question, with multiple opportunities for public input included. Consensus was reached on all DGAC's findings, including each conclusion and recommendation, and the entire report. When research questions were answered by original systematic literature reviews and/or with existing, high-quality expert reports, the quality and strength of the evidence was formally graded. The report was organized around the following 5 themes: 1) food and nutrient intakes and health: current status and trends; 2) dietary patterns, foods and nutrients, and health outcomes; 3) diet and physical activity behavior change; 4) food and physical activity environments; and 5) food sustainability and food safety. The following 3 cross-cutting topics were addressed: 1) sodium, 2) saturated fat, and 3) added sugars. Physical activity recommendations from recent expert reports were endorsed. The overall quality of the American diet was assessed to identify overconsumed and underconsumed nutrients of public health concern. Common food characteristics of healthy dietary patterns were determined. Features of effective interventions to change individual and population diet and physical activity behaviors in clinical, public

  6. Definition of sampling units begets conclusions in ecology: the case of habitats for plant communities.

    Science.gov (United States)

    Mörsdorf, Martin A; Ravolainen, Virve T; Støvern, Leif Einar; Yoccoz, Nigel G; Jónsdóttir, Ingibjörg Svala; Bråthen, Kari Anne

    2015-01-01

    In ecology, expert knowledge on habitat characteristics is often used to define sampling units such as study sites. Ecologists are especially prone to such approaches when prior sampling frames are not accessible. Here we ask to what extent can different approaches to the definition of sampling units influence the conclusions that are drawn from an ecological study? We do this by comparing a formal versus a subjective definition of sampling units within a study design which is based on well-articulated objectives and proper methodology. Both approaches are applied to tundra plant communities in mesic and snowbed habitats. For the formal approach, sampling units were first defined for each habitat in concave terrain of suitable slope using GIS. In the field, these units were only accepted as the targeted habitats if additional criteria for vegetation cover were fulfilled. For the subjective approach, sampling units were defined visually in the field, based on typical plant communities of mesic and snowbed habitats. For each approach, we collected information about plant community characteristics within a total of 11 mesic and seven snowbed units distributed between two herding districts of contrasting reindeer density. Results from the two approaches differed significantly in several plant community characteristics in both mesic and snowbed habitats. Furthermore, differences between the two approaches were not consistent because their magnitude and direction differed both between the two habitats and the two reindeer herding districts. Consequently, we could draw different conclusions on how plant diversity and relative abundance of functional groups are differentiated between the two habitats depending on the approach used. We therefore challenge ecologists to formalize the expert knowledge applied to define sampling units through a set of well-articulated rules, rather than applying it subjectively. We see this as instrumental for progress in ecology as only rules

  7. Definition of sampling units begets conclusions in ecology: the case of habitats for plant communities

    Directory of Open Access Journals (Sweden)

    Martin A. Mörsdorf

    2015-03-01

    Full Text Available In ecology, expert knowledge on habitat characteristics is often used to define sampling units such as study sites. Ecologists are especially prone to such approaches when prior sampling frames are not accessible. Here we ask to what extent can different approaches to the definition of sampling units influence the conclusions that are drawn from an ecological study? We do this by comparing a formal versus a subjective definition of sampling units within a study design which is based on well-articulated objectives and proper methodology. Both approaches are applied to tundra plant communities in mesic and snowbed habitats. For the formal approach, sampling units were first defined for each habitat in concave terrain of suitable slope using GIS. In the field, these units were only accepted as the targeted habitats if additional criteria for vegetation cover were fulfilled. For the subjective approach, sampling units were defined visually in the field, based on typical plant communities of mesic and snowbed habitats. For each approach, we collected information about plant community characteristics within a total of 11 mesic and seven snowbed units distributed between two herding districts of contrasting reindeer density. Results from the two approaches differed significantly in several plant community characteristics in both mesic and snowbed habitats. Furthermore, differences between the two approaches were not consistent because their magnitude and direction differed both between the two habitats and the two reindeer herding districts. Consequently, we could draw different conclusions on how plant diversity and relative abundance of functional groups are differentiated between the two habitats depending on the approach used. We therefore challenge ecologists to formalize the expert knowledge applied to define sampling units through a set of well-articulated rules, rather than applying it subjectively. We see this as instrumental for progress in

  8. Partial Differential Equations in General Relativity

    International Nuclear Information System (INIS)

    Choquet-Bruhat, Yvonne

    2008-01-01

    General relativity is a physical theory basic in the modeling of the universe at the large and small scales. Its mathematical formulation, the Einstein partial differential equations, are geometrically simple, but intricate for the analyst, involving both hyperbolic and elliptic PDE, with local and global problems. Many problems remain open though remarkable progress has been made recently towards their solutions. Alan Rendall's book states, in a down-to-earth form, fundamental results used to solve different types of equations. In each case he gives applications to special models as well as to general properties of Einsteinian spacetimes. A chapter on ODE contains, in particular, a detailed discussion of Bianchi spacetimes. A chapter entitled 'Elliptic systems' treats the Einstein constraints. A chapter entitled 'Hyperbolic systems' is followed by a chapter on the Cauchy problem and a chapter 'Global results' which contains recently proved theorems. A chapter is dedicated to the Einstein-Vlasov system, of which the author is a specialist. On the whole, the book surveys, in a concise though precise way, many essential results of recent interest in mathematical general relativity, and it is very clearly written. Each chapter is followed by an up to date bibliography. In conclusion, this book will be a valuable asset to relativists who wish to learn clearly-stated mathematical results and to mathematicians who want to penetrate into the subtleties of general relativity, as a mathematical and physical theory. (book review)

  9. Partial Differential Equations in General Relativity

    Energy Technology Data Exchange (ETDEWEB)

    Choquet-Bruhat, Yvonne

    2008-09-07

    General relativity is a physical theory basic in the modeling of the universe at the large and small scales. Its mathematical formulation, the Einstein partial differential equations, are geometrically simple, but intricate for the analyst, involving both hyperbolic and elliptic PDE, with local and global problems. Many problems remain open though remarkable progress has been made recently towards their solutions. Alan Rendall's book states, in a down-to-earth form, fundamental results used to solve different types of equations. In each case he gives applications to special models as well as to general properties of Einsteinian spacetimes. A chapter on ODE contains, in particular, a detailed discussion of Bianchi spacetimes. A chapter entitled 'Elliptic systems' treats the Einstein constraints. A chapter entitled 'Hyperbolic systems' is followed by a chapter on the Cauchy problem and a chapter 'Global results' which contains recently proved theorems. A chapter is dedicated to the Einstein-Vlasov system, of which the author is a specialist. On the whole, the book surveys, in a concise though precise way, many essential results of recent interest in mathematical general relativity, and it is very clearly written. Each chapter is followed by an up to date bibliography. In conclusion, this book will be a valuable asset to relativists who wish to learn clearly-stated mathematical results and to mathematicians who want to penetrate into the subtleties of general relativity, as a mathematical and physical theory. (book review)

  10. Microwave measurements of water vapor partial pressure at high temperatures

    International Nuclear Information System (INIS)

    Latorre, V.R.

    1991-01-01

    One of the desired parameters in the Yucca Mountain Project is the capillary pressure of the rock comprising the repository. This parameter is related to the partial pressure of water vapor in the air when in equilibrium with the rock mass. Although there are a number of devices that will measure the relative humidity (directly related to the water vapor partial pressure), they generally will fail at temperatures on the order of 150C. Since thee author has observed borehole temperatures considerably in excess of this value in G-Tunnel at the Nevada Test Site (NTS), a different scheme is required to obtain the desired partial pressure data at higher temperatures. This chapter presents a microwave technique that has been developed to measure water vapor partial pressure in boreholes at temperatures up to 250C. The heart of the system is a microwave coaxial resonator whose resonant frequency is inversely proportional to the square root of the real part of the complex dielectric constant of the medium (air) filling the resonator. The real part of the dielectric constant of air is approximately equal to the square of the refractive index which, in turn, is proportional to the partial pressure of the water vapor in the air. Thus, a microwave resonant cavity can be used to measure changes in the relative humidity or partial pressure of water vapor in the air. Since this type of device is constructed of metal, it is able to withstand very high temperatures. The actual limitation is the temperature limit of the dielectric material in the cable connecting the resonator to its driving and monitoring equipment-an automatic network analyzer in our case. In the following sections, the theory of operation, design, construction, calibration and installation of the microwave diagnostics system is presented. The results and conclusions are also presented, along with suggestions for future work

  11. Nonlinear Scattering from Partially Closed Cracks and Imperfect Interfaces

    International Nuclear Information System (INIS)

    Pecorari, Claudio

    2004-05-01

    This project has investigated the potential offered by nonlinear scattering phenomena to detect stress-corrosion, surface-breaking cracks, and regions of extended interfaces which are often invisible to conventional inspection methods because of their partial closure and/or the high background noise generated by the surrounding microstructure. The investigation has looked into the basic physics of the interaction between ultrasonic waves and rough surfaces in contact, since the latter offers a prototypical example of a mechanical system which is characterized by a dynamics similar to that of a partially closed crack. To this end, three fundamental mechanisms which may be activated by an inspecting ultrasonic wave have been considered. The first mechanism is described by the Hertz force law which governs the interaction between asperities in contact that are subjected to a normal load. The second mechanism considers the dynamics of two spherical asperities subjected to an oscillating tangential load. To this end, the model developed by Mindlin and Deresiewizc has been used. The third mechanism accounts for the effect of forces of adhesion, and can be described by a model developed by Greenwood and Johnson. The validity of this model is rather general and covers the extreme cases of very soft and very rigid contacts. This model aims at describing the effect of fluid layers with thickness of atomic size, which may be present within a crack. Statistical models accounting for the topography of the two rough surfaces in contact have been developed, and the macroscopic stiffness of the interface recovered. These results have been used to formulate effective boundary conditions to be enforced at the interface, and the reflection and transmission problem has been solved in a variety of situations of experimental significance. The main conclusion of this part of the project is that the second harmonic component is the dominant feature of the nonlinear response of an

  12. OECD/CSNI Workshop on In-Vessel Core Debris Retention and Coolability - Summary and Conclusions

    International Nuclear Information System (INIS)

    Behbahani, Ali-Reza; Drozd, Andrzej; Kim, Sang-Baik; Micaelli, Jean-Claude; Okkonen, Timo; Sugimoto, Jun; Trambauer, Klaus; Tuomisto, Harri

    1999-01-01

    In the spring of 1994 an OECD Workshop on Large Pool Heat transfer was held in Grenoble. The scope of this workshop was the investigation of (1) molten pool heat transfer, (2) heat transfer to the surrounding water, and (3) the feasibility of in-vessel core debris cooling through external cooling of the vessel. Since this time, experimental test series have been completed (e.g., COPO, ULPU, CORVIS) and new experimental programs (e.g., BALI, SONATA, RASPLAV, debris and gap heat transfer) have been established to consolidate and expand the data base for further model development and to improve the understanding of in-vessel debris retention and coolability in a nuclear power plant. Discussions within the CSNI's PWG-2 and the Task Group on Degraded Core Cooling (TG-DCC) have led to the conclusion that the time was ripe for organizing a new international Workshop with the objectives: - to review the results of experimental research that has been conducted in this area; - to exchange information on the results of member countries experiments and model development on in-vessel core debris retention and coolability; - to discuss areas where additional experimental research is needed in order to provide an adequate data base for analytical model development for core debris retention and coolability. The scope of this workshop was limited to the phenomena connected to in-vessel core debris retention and coolability and did not include steam explosion and fission product issues. The workshop was structured into the following sessions: Key note papers; Experiments and model development; Debris bed heat transfer; Corium properties, molten pool convection and crust formation; Gap formation and gap cooling; Creep behaviour of reactor pressure vessel lower head; Ex-vessel boiling and critical heat flux phenomena; Scaling to reactor severe accident conditions and reactor applications. Compared to the previous workshop held in Grenoble in 1994, large progress has been made in the

  13. On an experimental curiosity that if undetected may lead to erroneous far-reaching conclusions

    International Nuclear Information System (INIS)

    Noninski, V.C.; Ciottone, J.L.; White, P.J.

    1997-01-01

    This letter gives a brief discussion of the possibilities of inducing nuclear effects by carrying out only chemical reactions. Undoubtedly, this interest is a result of the still unresolved problem of 'cold fusion,' and some colleagues tend to see a clear connection, and even an extension of the studies, between cold fusion and the alleged chemical transmutation of elements. While we have already published thorough reports (negative so far) of our studies with regard to the claimed increase of gamma-ray emission and beta decay after burning of a mixture of chemicals, this letter informs the Fusion Technology readership of an experimental curiosity that is encountered during similar studies that initially led us to an erroneous conclusion. As in previous studies, we compared certain radiochemical properties of a mixture of chemicals before and after a chemical reaction (burning). Under discussion here is a peak that we observed in the range of 412 keV in the gamma spectrum in one of the burned samples after neutron activating it for 3 min at 1 kW. This peak was ostensibly not present in the same sample unburned. 4 refs., 2 figs

  14. Development integration via real and technological convergence. Experience of Poland and conclusions for Ukraine

    Directory of Open Access Journals (Sweden)

    Michał G. Woźniak

    2014-09-01

    Full Text Available The paper summarizes main achievements, losses and gains during the first decade of Poland's membership in the EU, while also aiming at development of suggestions for the Polish economic policy in the years to come, as well as draws conclusions for Ukraine, which has now elected the strategy of international economic cooperation. The first part of the paper presents an empirical analysis of Poland's both real and technological convergence with the developed EU countries. These data show that since 1994, as the process of Poland integration with the EU commenced, our country significantly reduced the income and technology gap as compared to the EU. During the financial crisis, Poland 'felt' better than most European countries. In the second part of the paper we attempt to answer the question as to the current conditions of Polish economy development. It is demonstrated that Poland's economic success was due to multiple factors such as endogenous and exogenous, historical and those derived from present events. However, it can be assumed that integration with the EU has been an important positive factor in development of Poland during recent 20 years. Great importance was also vested in the implementation of economic reforms in Poland as well as in policy of the government, although not faultless. The last section of the paper identifies problems now faced by the EU and individual member states, including Poland as regards future years till 2020

  15. Paradigm, experiment and conclusion: La Casa by Bernard Rudofsky in three acts

    Directory of Open Access Journals (Sweden)

    Héctor García-Diego Villarías

    2018-04-01

    Full Text Available La Casa –or in English, the house– that Bernard Rudofsky built on the Spanish Mediterranean coast in 1971 is a valuable case study on the operational possibilities of popular architecture in the practice of this contemporary discipline. It is a repository of theoretical references typical of the vernacular world; its author, known for the exhibition Architecture without Architects, is emblematic of this type of architecture to which he dedicated much of his efforts as a theorist and polemicist throughout the course of his life. Additionally, La Casa is a unique architectural feat as it involves the practical materialization of its implicated theoretical position. It is possible that a concrete conclusion can be drawn from this case, which may shed light on the possible operability of a type of architecture that presents more than a few difficulties for the current context of the discipline, despite being habitually admired and praised. Additionally, the text presented here brings to light unpublished information found in the personal diaries of the architect that allows for the recreation of the circumstances surrounding the ideation and construction of this piece of architecture.

  16. Permutation entropy based time series analysis: Equalities in the input signal can lead to false conclusions

    Energy Technology Data Exchange (ETDEWEB)

    Zunino, Luciano, E-mail: lucianoz@ciop.unlp.edu.ar [Centro de Investigaciones Ópticas (CONICET La Plata – CIC), C.C. 3, 1897 Gonnet (Argentina); Departamento de Ciencias Básicas, Facultad de Ingeniería, Universidad Nacional de La Plata (UNLP), 1900 La Plata (Argentina); Olivares, Felipe, E-mail: olivaresfe@gmail.com [Instituto de Física, Pontificia Universidad Católica de Valparaíso (PUCV), 23-40025 Valparaíso (Chile); Scholkmann, Felix, E-mail: Felix.Scholkmann@gmail.com [Research Office for Complex Physical and Biological Systems (ROCoS), Mutschellenstr. 179, 8038 Zurich (Switzerland); Biomedical Optics Research Laboratory, Department of Neonatology, University Hospital Zurich, University of Zurich, 8091 Zurich (Switzerland); Rosso, Osvaldo A., E-mail: oarosso@gmail.com [Instituto de Física, Universidade Federal de Alagoas (UFAL), BR 104 Norte km 97, 57072-970, Maceió, Alagoas (Brazil); Instituto Tecnológico de Buenos Aires (ITBA) and CONICET, C1106ACD, Av. Eduardo Madero 399, Ciudad Autónoma de Buenos Aires (Argentina); Complex Systems Group, Facultad de Ingeniería y Ciencias Aplicadas, Universidad de los Andes, Av. Mons. Álvaro del Portillo 12.455, Las Condes, Santiago (Chile)

    2017-06-15

    A symbolic encoding scheme, based on the ordinal relation between the amplitude of neighboring values of a given data sequence, should be implemented before estimating the permutation entropy. Consequently, equalities in the analyzed signal, i.e. repeated equal values, deserve special attention and treatment. In this work, we carefully study the effect that the presence of equalities has on permutation entropy estimated values when these ties are symbolized, as it is commonly done, according to their order of appearance. On the one hand, the analysis of computer-generated time series is initially developed to understand the incidence of repeated values on permutation entropy estimations in controlled scenarios. The presence of temporal correlations is erroneously concluded when true pseudorandom time series with low amplitude resolutions are considered. On the other hand, the analysis of real-world data is included to illustrate how the presence of a significant number of equal values can give rise to false conclusions regarding the underlying temporal structures in practical contexts. - Highlights: • Impact of repeated values in a signal when estimating permutation entropy is studied. • Numerical and experimental tests are included for characterizing this limitation. • Non-negligible temporal correlations can be spuriously concluded by repeated values. • Data digitized with low amplitude resolutions could be especially affected. • Analysis with shuffled realizations can help to overcome this limitation.

  17. Pressure Measurement Techniques for Abdominal Hypertension: Conclusions from an Experimental Model.

    Science.gov (United States)

    Chopra, Sascha Santosh; Wolf, Stefan; Rohde, Veit; Freimann, Florian Baptist

    2015-01-01

    Introduction. Intra-abdominal pressure (IAP) measurement is an indispensable tool for the diagnosis of abdominal hypertension. Different techniques have been described in the literature and applied in the clinical setting. Methods. A porcine model was created to simulate an abdominal compartment syndrome ranging from baseline IAP to 30 mmHg. Three different measurement techniques were applied, comprising telemetric piezoresistive probes at two different sites (epigastric and pelvic) for direct pressure measurement and intragastric and intravesical probes for indirect measurement. Results. The mean difference between the invasive IAP measurements using telemetric pressure probes and the IVP measurements was -0.58 mmHg. The bias between the invasive IAP measurements and the IGP measurements was 3.8 mmHg. Compared to the realistic results of the intraperitoneal and intravesical measurements, the intragastric data showed a strong tendency towards decreased values. The hydrostatic character of the IAP was eliminated at high-pressure levels. Conclusion. We conclude that intragastric pressure measurement is potentially hazardous and might lead to inaccurately low intra-abdominal pressure values. This may result in missed diagnosis of elevated abdominal pressure or even ACS. The intravesical measurements showed the most accurate values during baseline pressure and both high-pressure plateaus.

  18. Micah 7:8-20: An apt conclusion to the book of Micah

    Directory of Open Access Journals (Sweden)

    W J Wessels

    2003-10-01

    Full Text Available It is argued in this article that Micah 7:8-20 forms an apt conclusion to the book of Micah. As was the case with Micah 1, the concluding section also focusses on Yahweh and his dealings with the people of the earth. There is a universal tendency to be detected in this section as well. An important aspect to notice� is� the liturgical nature of chapters six and seven, especially 7:8-20. There is a vagueness, almost a timelessness, imbuing this section. This could be intended allowing later generations of believers to apply these words to� their� own� circumstances. With Micah 7:8-20 as the concluding section of the book, one is left with a sense of well-roundedness, of completeness. The collection of oracles attributed� to Micah in general has a sombre tone. For this very reason Micah� 7:8-20� seems� to� change� the mood. It breathes hope into a negative atmosphere of judgment. It ends with a strong emphasis on the power of Yahweh, the power of forgiveness.

  19. Results and Conclusions from the NASA Isokinetic Total Water Content Probe 2009 IRT Test

    Science.gov (United States)

    Reehorst, Andrew; Brinker, David

    2010-01-01

    The NASA Glenn Research Center has developed and tested a Total Water Content Isokinetic Sampling Probe. Since, by its nature, it is not sensitive to cloud water particle phase nor size, it is particularly attractive to support super-cooled large droplet and high ice water content aircraft icing studies. The instrument comprises the Sampling Probe, Sample Flow Control, and Water Vapor Measurement subsystems. Results and conclusions are presented from probe tests in the NASA Glenn Icing Research Tunnel (IRT) during January and February 2009. The use of reference probe heat and the control of air pressure in the water vapor measurement subsystem are discussed. Several run-time error sources were found to produce identifiable signatures that are presented and discussed. Some of the differences between measured Isokinetic Total Water Content Probe and IRT calibration seems to be caused by tunnel humidification and moisture/ice crystal blow around. Droplet size, airspeed, and liquid water content effects also appear to be present in the IRT calibration. Based upon test results, the authors provide recommendations for future Isokinetic Total Water Content Probe development.

  20. Conclusions from working group 2 - the analyses of the WIPP-2 experiments

    International Nuclear Information System (INIS)

    Jackson, C.P.

    1995-01-01

    The INTRAVAL WIPP-2 test case is based on data from site investigations carried out at the Waste Isolation Pilot Plant (WIPP) in New Mexico, USA. The site has been chosen as a potential location for a radioactive waste repository. Extensive investigations have been carried out, focused mainly on groundwater flow and transport in the Culebra Dolomite, the main pathway for transport of radionuclides off the site by groundwater in the case of an accidental borehole intrusion into the repository. Five teams studied the test case. Two teams addressed issues involved in the treatment of heterogeneity. Stochastic models and a Monte Carlo approach were used. One team quantified the increased uncertainty resulting from fewer data and explored the issues involved in validation of stochastic models. A second team developed a new method for conditioning stochastic models on head data. Two other teams examined issues relating to the choice of conceptual models. Two-dimensional vertical cross-section models were used to explore the importance of vertical flow. The fifth team advocate the use of a variety of models to highlight the most important processes and parameters. Conclusions from each team experiment are analysed. (J.S.). 4 refs., 11 figs

  1. A fine-grained analysis of the jumping-to-conclusions bias in schizophrenia

    Directory of Open Access Journals (Sweden)

    Steffen Moritz

    2009-12-01

    Full Text Available Impaired decision behavior has been repeatedly observed in schizophrenia patients. We investigated several cognitive mechanisms that might contribute to the jumping-to-conclusions bias (JTC seen in schizophrenia patients: biases in information-gathering, information weighting and integration, and overconfidence, using the process tracing paradigm Mouselab. Mouselab allows for an in-depth exploration of various decision-making processes in a structured information environment. A total of 37 schizophrenia patients and 30 healthy controls participated in the experiment. Although showing less focused and systematic information search, schizophrenia patients practically considered all pieces of information and showed no JTC in the sense of collecting less pieces of evidence. Choices of patients and controls both approximated a rational solution quite well, but patients showed more extreme confidence ratings. Both groups mainly used weighted additive decision strategies for information integration and only a small proportion relied on simple heuristics. Under high stress induced by affective valence plus time pressure, however, schizophrenia patients switched to equal weighting strategies: less valid cues and more valid ones were weighted equally.

  2. Methodology and conclusions of activation calculations of WWER-440 type nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Babcsány, Boglárka, E-mail: boglarka.babcsany@reak.bme.hu; Czifrus, Szabolcs; Fehér, Sándor

    2015-04-01

    Highlights: • Activation calculation of two WWER-440 type nuclear power plants. • Detailed description of the applied activation calculation methodology. • Graphical results for total activity and waste index categorization. • General conclusions for activation applicable in the case of PWR reactors. - Abstract: Activation calculations for two nuclear power plants of WWER-440 type have been performed by the authors in order to assist the decommissioning planning by assessing the radioactive inventory present at the time of and at different times after the final shutdown. According to related international literature and studies performed earlier by the authors, considering the activity more than 99% of this inventory is concentrated in the materials directly surrounding the reactor core, where the predominant evolution of radionuclides is generated by neutron induced nuclear reactions. In order to obtain the highest possible accuracy in modelling, three-dimensional Monte Carlo neutron transport calculations were performed. Besides the methods and models applied to these analyses, the paper also summarizes the results that can be generally applied to such nuclear power plant types. At the time of shutdown, the total activity of the stainless steel components is about 6 × 10{sup 16} Bq and 1.3 × 10{sup 17} Bq for the two NPPs considered. The biological shielding concrete constitutes approximately 7 × 10{sup 13} Bq and 1.1 × 10{sup 14} Bq.

  3. Iron deficiency anaemia: with the conclusion of a need for iron reader

    Science.gov (United States)

    Lim, Wai Feng; Yap, Boon Kar; Lai, Mei I.; Talik, Noorazrina; Nasser, Ammar Ahmed; Al-Haiqi, Ahmed Mubarak Ahmed; Sankar Krishnan, Prajindra

    2017-10-01

    In our bloodstream, there are plenty of red blood cells (RBC), which function as an important oxygen carrier in our bodies. Each RBC consists of millions of haemoglobin (Hb), which is made up from globin and iron. If any deficiency/malfunction of any globin, it will lead to anaemia as indicated in low Hb level while iron deficiency anaemia (IDA) is anaemic due to the lacking of iron as indicated in low Hb and ferritin levels. IDA affects almost two billion people globally while anaemia without iron deficiency, such as thalassaemia, affects almost 4.5% in Malaysian population. These anaemic conditions have similar clinical symptoms like fatigue, dizziness, in which disturb their cognitive development and productivity in workplace. In areas without proper medical access, many anaemic individuals were misdiagnosed and treated with iron tablets because they were thought to have iron deficiency anaemia due to low Hb content. But, excess iron is toxic to the body. Misdiagnosis can be avoided by iron status assessment. We hereby review the currently available iron status parameters in laboratory and field study with the conclusion of demonstrating the importance of a need for iron reader, in the effort to reduce the prevalence of IDA globally.

  4. Total Knee Arthroplasty for Knee Osteoarthritis: Support for a Foregone Conclusion?

    Science.gov (United States)

    Steinhaus, Michael E; Christ, Alexander B; Cross, Michael B

    2017-07-01

    Total knee arthroplasty (TKA) is generally accepted as the definitive treatment for advanced knee arthritis after patients fail nonoperative treatments; however, the safety and efficacy of TKA compared to continued nonoperative treatment has never been proven in high-quality, randomized controlled trials. Recently, a 2015 Danish study published a 12-month follow-up on a cohort of patients randomized to either a TKA or continued nonsurgical management for advanced knee osteoarthritis (OA). The authors reported significantly greater improvement in the TKA group in functional outcome scores such as the overall Knee Injury and Osteoarthritis Outcome Score (KOOS 4 score), the KOOS subscales, EQ-5D descriptive index, and timed get up-and-go and 20-m walk tests; however, patients in the TKA did suffer significantly more serious adverse events (SAE). The authors concluded that TKA combined with additional nonoperative care postoperatively is more efficacious than nonsurgical treatment alone in terms of improving pain, function, and quality of life at 12 months but is associated with more SAE. The purpose of this review is to identify the strengths and weaknesses of this trial, interpret its outcomes within the context of prior literature, and evaluate the validity of its conclusions.

  5. Blast Testing Issues and TBI; Experimental Models that Lead to Wrong Conclusions

    Directory of Open Access Journals (Sweden)

    Charles E. Needham

    2015-04-01

    Full Text Available Over the past several years we have noticed an increase in the number of blast injury studies published in peer-reviewed biomedical journals that have utilized improperly conceived experiments. Data from these studies will lead to false conclusions and more confusion than advancement in the understanding of blast injury, particularly blast neurotrauma. Computational methods to properly characterize the blast environment have been available for decades. These methods, combined with a basic understanding of blast wave phenomena enable researchers to extract useful information from well documented experiments. This basic understanding must include the differences and interrelationships of static pressure, dynamic pressure, reflected pressure, and total or stagnation pressure in transient shockwave flows, how they relate to loading of objects, and how they are properly measured. However, it is critical that the research community effectively overcomes the confusion that has been compounded by a misunderstanding of the differences between the loading produced by a free field explosive blast and loading produced by a conventional shock tube. The principles of blast scaling have been well established for decades and when properly applied will do much to repair these problems.This paper provides guidance regarding proper experimental methods and offers insights into the implications of improperly designed and executed tests. Through application of computational methods, useful data can be extracted from well documented historical tests, and future work can be conducted in a way to maximize the effectiveness and use of valuable biological test data.

  6. Osiris and SOMBRERO inertial fusion power plant designs - summary, conclusions, and recommendations

    International Nuclear Information System (INIS)

    Meier, Wayne R.

    1994-01-01

    An 18 month study to evaluate the potential of inertial fusion energy (IFE) for electric power production has been completed. The primary objective of the study was to provide the US Department of Energy with an evaluation of the potential of inertial fusion for electric power production. The study included the conceptual design of two inertial fusion power plants. Osiris uses an induction linac heavy ion beam driver, and SOMBRERO uses a krypton fluoride laser driver. Conceptual designs were completed for the reactors, power conversion and plant facilities, and drivers. Environmental and safety aspects, technical issues, technology development needs, and economics of the final point designs were assessed and compared. This paper summarizes the results and conclusions of the conceptual designs and results of the assessment studies. We conclude that IFE has the potential of producing technically credible designs with environmental, safety, and economics characteristics that are just as attractive as magnetic fusion. Realizing this potential will require additional research and development on target physics, chamber design, target production and injection systems, and drivers. ((orig.))

  7. KiKK: An endless story or the long way to come to a conclusion?

    International Nuclear Information System (INIS)

    Michel, Rolf; Mueller, Wolfgang-Ulrich

    2009-01-01

    More than one year after the publication of the KiKK-Study (Epidemiological Study on Childhood Cancer in the Vicinity of Nuclear Power Plants), which reported a statistical correlation between the proximity of a person's residence to the nearest nuclear power plant, at the time of diagnosis, and the person's risk of contracting cancer (or leukaemia) prior to his or her fifth birthday, the SSK presented its assessment and the related scientific explanatory statement to the public on the occasion of an expert discussion in Bonn on February 26, 2009, This article describes the background of the SSK deliberations and gives a survey of its essential results and conclusions. In total, the results are unsatisfactory, since the SSK was not able to explain the findings of the KiKK-Study. However, this was not unexpected considering the international state of knowledge regarding the development of childhood cancer. Considering the fact, that the radiation exposure of members of the public, originating from the nuclear power plants even at the locations of the potentially highest exposures, is by orders of magnitude lower than the natural radiation exposures, the SSK was able to exclude the radiation from the nuclear power plants as cause of the observed increased relative risks. Any more far-reaching explanation attempts would be mere speculation. It is still a long way to know how childhood cancer develops and how the results of the KiKK-Study or other small-scale enhancements of the cancer risk can be explained. (orig.)

  8. Summary and conclusions of the specialist meeting on severe accident management programme development

    International Nuclear Information System (INIS)

    1992-01-01

    The CSNI Specialist meeting on severe accident management programme development was held in Rome and about seventy experts from thirteen countries attended the meeting. A total of 27 papers were presented in four sessions, covering specific aspects of accident management programme development. It purposely focused on the programmatic aspects of accident management rather than on some of the more complex technical issues associated with accident management strategies. Some of the major observations and conclusions from the meeting are that severe accident management is the ultimate part of the defense in depth concept within the plant. It is function and success oriented, not event oriented, as the aim is to prevent or minimize consequences of severe accidents. There is no guarantee it will always be successful but experts agree that it can reduce the risks significantly. It has to be exercised and the importance of emergency drills has been underlined. The basic structure and major elements of accident management programmes appear to be similar among OECD member countries. Dealing with significant phenomenological uncertainties in establishing accident management programmes continues to be an important issue, especially in confirming the appropriateness of specific accident management strategies

  9. Impact of removable partial denture prosthesis on chewing efficiency

    Science.gov (United States)

    BESSADET, Marion; NICOLAS, Emmanuel; SOCHAT, Marine; HENNEQUIN, Martine; VEYRUNE, Jean-Luc

    2013-01-01

    Removable partial denture prostheses are still being used for anatomic, medical and economic reasons. However, the impact on chewing parameters is poorly described. Objectives The objective of this study was to estimate the impact of removable partial denture prosthesis on masticatory parameters. Material and Methods Nineteen removable partial denture prosthesis (RPDP) wearers participated in the study. Among them, 10 subjects were Kennedy Class III partially edentulous and 9 with posterior edentulism (Class I). All presented a complete and full dentate opposing arch. The subjects chewed samples of carrots and peanuts with and without their prosthesis. The granulometry of the expectorated boluses from carrot and peanuts was characterized by median particle size (D50), determined at the natural point of swallowing. Number of chewing cycles (CC), chewing time (CT) and chewing frequency (CF=CC/CT) were video recorded. Results With RPDP, the mean D50 values for carrot and peanuts were lower [Repeated Model Procedures (RMP), F=15, p<0.001] regardless of the type of Kennedy Class. For each food, mean CC, CT and CF values recorded decreased (RMP, F=18, F=9, and F=20 respectively, p<0.01). With or without RPD, the boluses' granulometry values were above the masticatory normative index (MNI) determined as 4,000 µm. Conclusion RPDP rehabilitation improves the ability to reduce the bolus particle size, but does not reestablish fully the masticatory function. Clinical relevance This study encourages the clinical improvement of oral rehabilitation procedure. PMID:24212983

  10. Structure validation of the Josephin domain of ataxin-3: Conclusive evidence for an open conformation

    International Nuclear Information System (INIS)

    Nicastro, Giuseppe; Habeck, Michael; Masino, Laura; Svergun, Dmitri I.; Pastore, Annalisa

    2006-01-01

    The availability of new and fast tools in structure determination has led to a more than exponential growth of the number of structures solved per year. It is therefore increasingly essential to assess the accuracy of the new structures by reliable approaches able to assist validation. Here, we discuss a specific example in which the use of different complementary techniques, which include Bayesian methods and small angle scattering, resulted essential for validating the two currently available structures of the Josephin domain of ataxin-3, a protein involved in the ubiquitin/proteasome pathway and responsible for neurodegenerative spinocerebellar ataxia of type 3. Taken together, our results demonstrate that only one of the two structures is compatible with the experimental information. Based on the high precision of our refined structure, we show that Josephin contains an open cleft which could be directly implicated in the interaction with polyubiquitin chains and other partners

  11. Climate change impact on shallow groundwater conditions in Hungary: Conclusions from a regional modelling study

    Science.gov (United States)

    Kovács, Attila; Marton, Annamária; Tóth, György; Szöcs, Teodóra

    2016-04-01

    A quantitative methodology has been developed for the calculation of groundwater table based on measured and simulated climate parameters. The aim of the study was to develop a toolset which can be used for the calculation of shallow groundwater conditions for various climate scenarios. This was done with the goal of facilitating the assessment of climate impact and vulnerability of shallow groundwater resources. The simulated groundwater table distributions are representative of groundwater conditions at the regional scale. The introduced methodology is valid for modelling purposes at various scales and thus represents a versatile tool for the assessment of climate vulnerability of shallow groundwater bodies. The calculation modules include the following: 1. A toolset to calculate climate zonation from climate parameter grids, 2. Delineation of recharge zones (Hydrological Response Units, HRUs) based on geology, landuse and slope conditions, 3. Calculation of percolation (recharge) rates using 1D analytical hydrological models, 4. Simulation of the groundwater table using numerical groundwater flow models. The applied methodology provides a quantitative link between climate conditions and shallow groundwater conditions, and thus can be used for assessing climate impacts. The climate data source applied in our calculation comprised interpolated daily climate data of the Central European CARPATCLIM database. Climate zones were determined making use of the Thorntwaite climate zonation scheme. Recharge zones (HRUs) were determined based on surface geology, landuse and slope conditions. The HELP hydrological model was used for the calculation of 1D water balance for hydrological response units. The MODFLOW numerical groundwater modelling code was used for the calculation of the water table. The developed methodology was demonstrated through the simulation of regional groundwater table using spatially averaged climate data and hydrogeological properties for various time

  12. Partial differential equations of mathematical physics

    CERN Document Server

    Sobolev, S L

    1964-01-01

    Partial Differential Equations of Mathematical Physics emphasizes the study of second-order partial differential equations of mathematical physics, which is deemed as the foundation of investigations into waves, heat conduction, hydrodynamics, and other physical problems. The book discusses in detail a wide spectrum of topics related to partial differential equations, such as the theories of sets and of Lebesgue integration, integral equations, Green's function, and the proof of the Fourier method. Theoretical physicists, experimental physicists, mathematicians engaged in pure and applied math

  13. [Removable partial dentures. Oral functions and types

    OpenAIRE

    Creugers, N.H.J.; Baat, C. de

    2009-01-01

    A removable partial denture enables the restoration or improvement of 4 oral functions: aesthetics, mandibular stability, mastication, and speech. However, wearing a removable partial denture should not cause oral comfort to deteriorate. There are 3 types of removable partial dentures: acrylic tissue-supported dentures, dentures with cast metal frameworks en dentures with cast metal frameworks and (semi)precision attachments. Interrupted tooth arches,free-ending tooth arches, and a combinatio...

  14. Partial vaginismus : definition, symptoms and treatment

    OpenAIRE

    Engman, Maria

    2007-01-01

    Vaginismus is a sexual pain disorder, where spasm of musculature of the outer third of the vagina interferes with intercourse. Vaginismus exists in two forms: total vaginismus, where intercourse is impossible, and the more seldom described partial vaginismus, in which intercourse is possible but painful. The aim of the thesis was to develop a useful definition of partial vaginismus for both clinical and scientific purposes; to describe the prevalence of partial vaginismus among women with sup...

  15. Partial Evaluation of the Euclidian Algorithm

    DEFF Research Database (Denmark)

    Danvy, Olivier; Goldberg, Mayer

    1997-01-01

    -like behavior. Each of them presents a challenge for partial evaluation. The Euclidian algorithm is one of them, and in this article, we make it amenable to partial evaluation. We observe that the number of iterations in the Euclidian algorithm is bounded by a number that can be computed given either of the two...... arguments. We thus rephrase this algorithm using bounded recursion. The resulting program is better suited for automatic unfolding and thus for partial evaluation. Its specialization is efficient....

  16. Partial distance correlation with methods for dissimilarities

    OpenAIRE

    Székely, Gábor J.; Rizzo, Maria L.

    2014-01-01

    Distance covariance and distance correlation are scalar coefficients that characterize independence of random vectors in arbitrary dimension. Properties, extensions, and applications of distance correlation have been discussed in the recent literature, but the problem of defining the partial distance correlation has remained an open question of considerable interest. The problem of partial distance correlation is more complex than partial correlation partly because the squared distance covari...

  17. Physicochemical, microbiological and sensory quality of noodles produced with partial replacement of wheat semolina by amaranth flour

    Directory of Open Access Journals (Sweden)

    Víctor Samir Vedia-Quispe

    2016-09-01

    Full Text Available Introduction: Pasta is a worldwide high consumption and acceptability food due to its low cost, easy preparation and storage. Pasta is usually made of edible wheat semolina and water. The replacement of wheat semolina by amaranth flour stimulates the development of new products and improves nutritional profile of pasta. The aim of this study was to assess physicochemical, microbiological and sensory properties of noodles made with partially replaced wheat semolina by whole grain and raw amaranth flours. Material and Methods: We evaluated the effect of the partial substitution (20% and 30% of wheat semolina using raw amaranth and whole grain amaranth flours in physicochemical, microbiological, quality characteristics and sensory analysis of acceptance. Results: The best treatment was the combination of 70% wheat semolina and 30% raw amaranth, where flavor was the factor in the overall acceptance, and some quality parameters correlated with the sensory responses. All pastas show sanitary quality and food safety. Conclusions: The partial substitution of amaranth flour, either raw or whole grain, improved significantly physicochemical characteristics of fiber with an increase of 60% and 140% in minerals (calcium and iron in the noodles.

  18. Reframing the science and policy of nicotine, illegal drugs and alcohol - conclusions of the ALICE RAP Project.

    Science.gov (United States)

    Anderson, Peter; Berridge, Virginia; Conrod, Patricia; Dudley, Robert; Hellman, Matilda; Lachenmeier, Dirk; Lingford-Hughes, Anne; Miller, David; Rehm, Jürgen; Room, Robin; Schmidt, Laura; Sullivan, Roger; Ysa, Tamyko; Gual, Antoni

    2017-01-01

    In 2013, illegal drug use was responsible for 1.8% of years of life lost in the European Union, alcohol was responsible for 8.2% and tobacco for 18.2%, imposing economic burdens in excess of 2.5% of GDP. No single European country has optimal governance structures for reducing the harm done by nicotine, illegal drugs and alcohol, and existing ones are poorly designed, fragmented, and sometimes cause harm. Reporting the main science and policy conclusions of a transdisciplinary five-year analysis of the place of addictions in Europe, researchers from 67 scientific institutions addressed these problems by reframing an understanding of addictions.  A new paradigm needs to account for evolutionary evidence which suggests that humans are biologically predisposed to seek out drugs, and that, today, individuals face availability of high drug doses, consequently increasing the risk of harm.  New definitions need to acknowledge that the defining element of addictive drugs is 'heavy use over time', a concept that could replace the diagnostic artefact captured by the clinical term 'substance use disorder', thus opening the door for new substances to be considered such as sugar. Tools of quantitative risk assessment that recognize drugs as toxins could be further deployed to assess regulatory approaches to reducing harm. Re-designed governance of drugs requires embedding policy within a comprehensive societal well-being frame that encompasses a range of domains of well-being, including quality of life, material living conditions and sustainability over time; such a frame adds arguments to the inappropriateness of policies that criminalize individuals for using drugs and that continue to categorize certain drugs as illegal. A health footprint, modelled on the carbon footprint, and using quantitative measures such as years of life lost due to death or disability, could serve as the accountability tool that apportions responsibility for who and what causes drug-related harm.

  19. Twenty years of children’s health monitoring: organization, results, conclusions

    Directory of Open Access Journals (Sweden)

    Aleksandra Anatol’evna Shabunova

    2015-05-01

    Full Text Available Deep understanding of human potential reproduction, presenting it as a continuous cycle and reflecting the continuity of generations, is significant for the formation of health and development of children. Today’s children will determine the future of Russian society. It is they who in 10–15 years will be a major part of the labor and creative population, a demographic base of the country. The research into children’s problems through the prism of socio-economic development helps identify targets of the state many-sided policy. The article presents results of the long-term medical sociological monitoring on the formation of child health carried out by the Institute of Socio-Economic Development of Territories of RAS with the support of the Vologda Oblast Healthcare Department since 1995. The special monitoring study of health dynamics in real time is unique not only for the Vologda Oblast, but for Russia as well. It reveals the transformation of a personality and the dependence of these changes on direct and indirect factors. The work’s feature is that it addresses an extremely important and wide range of issues: whether man was born healthy or not, if he/she is unhealthy, then why and why he/she was born unhealthy; whether his/her health after the birth is improving or deteriorating; if health is changing, what causes the changes. The 15 year observations disclose the dynamics of child health in the conditions of transformation processes taking place in the country. If the official statistics only records certain health trends, the monitoring results allow us to talk about them at a qualitatively new level. They reveal the underlying causes of demographic processes. The conclusion is, on the one hand, obvious and, on the other hand, it can not be neglected: economic stability and orderly development of the social sphere are critical for family well-being and child health. The reverse situation leads to the destruction of the family

  20. [Domestic elder abuse and neglect--conclusions from the evaluation of a model project].

    Science.gov (United States)

    Görgen, T; Nägele, B

    2005-02-01

    The main task of a federally funded model project in the German city of Hannover was to develop approaches for prevention and intervention in the field of domestic elder abuse. Over a three year period (1998-2001), different approaches--like a telephone helpline for senior citizens, and social workers operating as counsellors for elderly people and their relatives--were tested at a local level. The paper presents results from the evaluation of the project and draws conclusions for future prevention and intervention in the field. The authors argue that the explicit use of the conceptual framework of "violence"/"abuse" creates potentials for scandalizing the issue and is therefore supportive for media appearance, whereas it can impede the approach to the main target groups (elderly people and their relatives) and reduce accessibility of counselling services for potential clients. In the light of evaluation results the focus of the project ("domestic elder abuse" or "violence against elderly people in close relationships") was too narrow for a local project. Counselling services were used in a relatively small number of cases; analyses of cases show that incidents of domestic elder abuse are often embedded in complex problem constellations. Cases brought to the attention of the model project were multifaceted and not limited to incidents of neglect and abuse of elderly care recipients caused by caregiver overload. Cases of intimate violence in partnerships and of intergenerational violence without any of the participants being dependent on care show the need to develop a broader concept of domestic elder abuse. Integration of the concepts of domestic violence, violence against women, elder abuse/neglect and abuse/neglect in caregiving relationships is necessary on a conceptual level as well as on the level of interagency cooperation of institutions dealing with cases of "elder abuse".

  1. On the challenges of drawing conclusions from p-values just below 0.05

    Science.gov (United States)

    2015-01-01

    In recent years, researchers have attempted to provide an indication of the prevalence of inflated Type 1 error rates by analyzing the distribution of p-values in the published literature. De Winter & Dodou (2015) analyzed the distribution (and its change over time) of a large number of p-values automatically extracted from abstracts in the scientific literature. They concluded there is a ‘surge of p-values between 0.041–0.049 in recent decades’ which ‘suggests (but does not prove) questionable research practices have increased over the past 25 years.’ I show the changes in the ratio of fractions of p-values between 0.041–0.049 over the years are better explained by assuming the average power has decreased over time. Furthermore, I propose that their observation that p-values just below 0.05 increase more strongly than p-values above 0.05 can be explained by an increase in publication bias (or the file drawer effect) over the years (cf. Fanelli, 2012; Pautasso, 2010, which has led to a relative decrease of ‘marginally significant’ p-values in abstracts in the literature (instead of an increase in p-values just below 0.05). I explain why researchers analyzing large numbers of p-values need to relate their assumptions to a model of p-value distributions that takes into account the average power of the performed studies, the ratio of true positives to false positives in the literature, the effects of publication bias, and the Type 1 error rate (and possible mechanisms through which it has inflated). Finally, I discuss why publication bias and underpowered studies might be a bigger problem for science than inflated Type 1 error rates, and explain the challenges when attempting to draw conclusions about inflated Type 1 error rates from a large heterogeneous set of p-values. PMID:26246976

  2. Beads task vs. box task: The specificity of the jumping to conclusions bias.

    Science.gov (United States)

    Balzan, Ryan P; Ephraums, Rachel; Delfabbro, Paul; Andreou, Christina

    2017-09-01

    Previous research involving the probabilistic reasoning 'beads task' has consistently demonstrated a jumping-to-conclusions (JTC) bias, where individuals with delusions make decisions based on limited evidence. However, recent studies have suggested that miscomprehension may be confounding the beads task. The current study aimed to test the conventional beads task against a conceptually simpler probabilistic reasoning "box task" METHODS: One hundred non-clinical participants completed both the beads task and the box task, and the Peters et al. Delusions Inventory (PDI) to assess for delusion-proneness. The number of 'draws to decision' was assessed for both tasks. Additionally, the total amount of on-screen evidence was manipulated for the box task, and two new box task measures were assessed (i.e., 'proportion of evidence requested' and 'deviation from optimal solution'). Despite being conceptually similar, the two tasks did not correlate, and participants requested significantly less information on the beads task relative to the box task. High-delusion-prone participants did not demonstrate hastier decisions on either task; in fact, for box task, this group was observed to be significantly more conservative than low-delusion-prone group. Neither task was incentivized; results need replication with a clinical sample. Participants, and particularly those identified as high-delusion-prone, displayed a more conservative style of responding on the novel box task, relative to the beads task. The two tasks, whilst conceptually similar, appear to be tapping different cognitive processes. The implications of these results are discussed in relation to the JTC bias and the theoretical mechanisms thought to underlie it. Copyright © 2016 Elsevier Ltd. All rights reserved.

  3. Managing nuclear waste: a better idea (Excerpt of conclusions and recommendations)

    International Nuclear Information System (INIS)

    1984-12-01

    The panel concludes that an immediate effort must be made to improve the credibility, internal flexibility and cost-effectiveness of the Office of Civilian Radioactive Waste Management (OCRWM). However, in recognition that no modification to DOE/OCRWM organization would necessarily provide adequate stability and continuity, it is our principal recommendation that investigation of the specific steps necessary to implement, for example, a dedicated federally chartered corporation (the first choice of the Panel voting on organizational tests), should be undertaken immediately so that Congress can have a precise understanding of the legislative changes required to bring about such an organization. The main thrust of the Panel study has dealt with the structure and capabilities of various organizational alternatives for managing the high-level radioactive waste management program. The Panel also gave consideration to the financing processes of the Nuclear Waste Policy Act (NWPA), and to certain financing alternatives which might be substituted for the existing mechanisms. In doing so, the Panel encountered an array of financial uncertainties which confront the radioactive waste management program as it moves forward over the next two decades. At this juncture, it is extremely difficult to predict how future events, programmatic developments, and economic influences will affect the financing structure and cost level over the term of the program. It is the Panel's conclusion that the financing mechanism provided by Congress under the Nuclear Waste Policy Act appears to be fair, amenable to administrative implementation and cost controls, and sufficiently flexible to accommodate the full-recovery requirement of the legislation. Under NWPA, utilities are assessed a fee of 1 mill per kilowatthour of nuclear-generated electricity, plus a one-time fee for spent fuel accumulated prior to April 7, 1983

  4. The chooz a expert survey program and its main conclusions for plant life management

    International Nuclear Information System (INIS)

    Barthelet, B.; Heuze, A.; Hennart, J.C.; Havard, P.

    2001-01-01

    Because of the importance of PWR components life management represents for Electricity Companies, significant R and D programs are dedicated to identifying and analysing mechanisms and damage rates of the different degradation modes of these components, systems and structures. To assess R and D assumptions and to validate non destructive test results through reviews, expert survey programs on in-situ equipment may enhance the knowledge about most of the various phenomena involved. In this regard, an extensive program was launched after the Chooz A NPP was decommissioned in 1991, after 24 years in operation. This program gathered EDF, IPSN, FRAMATOME, ELECTRABEL and TRACTEBEL into partnership. The expert survey program was performed in various laboratories between 1995 and 1999 and includes: - on-site non destructive testing before sampling, - and metallurgical and mechanical tests performed on samples taken from the nuclear and non nuclear part of the unit. The expert survey program performed by Utilities in various laboratories involved the following equipment: - reactor vessel and internal equipment, - reactor coolant system (dissimilar metal welds, SS welds, cast austenitic ferritic steels), - feedwater plant piping (erosion-corrosion), - electric cables susceptible of temperature and irradiation induced ageing, - anchoring in civil engineering structures, - main primary circuit concerning activation measurement. In conclusion, the extensive Chooz A expert survey program yields numerous significant results. The main outcomes will contribute to validate non destructive tests and enhance our knowledge of some degradation mechanisms of often quite similar components present in units in operation. It is worthy to note that this program is of prime importance for operation feedback; the cost of the whole study amounts to approximately 10 Million Euros. (author)

  5. Radioactive-waste ocean dumping will have negligible enviromental impact. Conclusion of draft assessment of NSB

    Energy Technology Data Exchange (ETDEWEB)

    1976-11-01

    This draft report is the result of extensive studies based on the best available information in the field of oceanography, marine radiobiology and health physics. On various basic considerations, assessment was undertaken, and the following conclusion was reached. The quantity of radioactivity to be dumped at one time is assumed to be 500 Ci in the case of test dumping, and 10/sup 5/ Ci/year in the case of full-scale dumping. The conditions required for the dumping sea area are that the bottom water flow and upwelling amount are limited, and that the sea bottom is flat. The horizontal dispersion coefficient of 10/sup 7/ cm/sup 2//sec and the vertical dispersion coefficient of 2 x 10/sup 2/ cm/sup 2//sec are assumed. It is assumed that the radionuclides in the disposed package would leached out as soon as it reaches the sea bottom, and would not show any physicochemical behavior. Typycal radionuclides are classified into 5 groups in terms of their half lives, and their estimated concentrations at 1 km depth are tabulated. The maximum level of individual dose and the magnitude of population dose were assessed on the fishermen working in the dumping sea area, and the adults, children and infants who were expected to receive higher dose on account of the larger intake of fish products than average. The dose level given with the dose assessment model and various panamentors under the dumping conditions is much lower than natural radiation and the permissible level recommended by ICRP.

  6. Optimal Designs for the Generalized Partial Credit Model

    OpenAIRE

    Bürkner, Paul-Christian; Schwabe, Rainer; Holling, Heinz

    2018-01-01

    Analyzing ordinal data becomes increasingly important in psychology, especially in the context of item response theory. The generalized partial credit model (GPCM) is probably the most widely used ordinal model and finds application in many large scale educational assessment studies such as PISA. In the present paper, optimal test designs are investigated for estimating persons' abilities with the GPCM for calibrated tests when item parameters are known from previous studies. We will derive t...

  7. Comparative analysis of unilateral removable partial denture and classical removable partial denture by using finite element method

    Directory of Open Access Journals (Sweden)

    Radović Katarina

    2010-01-01

    Full Text Available Introduction. Various mobile devices are used in the therapy of unilateral free-end saddle. Unilateral dentures with precise connectivity elements are not used frequently. In this paper the problem of applying and functionality of unilateral freeend saddle denture without major connector was taken into consideration. Objective. The aim was to analyze and compare a unilateral RPD (removable partial denture and a classical RPD by calculating and analyzing stresses under different loads. Methods. 3D models of unilateral removable partial denture and classical removable partial denture with casted clasps were made by using computer program CATIA V5 (abutment teeth, canine and first premolar, with crowns and abutment tissues were also made. The models were built in full-scale. Stress analyses for both models were performed by applying a force of 300 N on the second premolar, a force of 500 N on the first molar and a force of 700 N on the second molar. Results. The Fault Model Extractor (FME analysis and calculation showed the complete behavior of unilateral removable partial denture and abutments (canine and first premolar, as well as the behavior of RPD under identical loading conditions. Applied forces with extreme values caused high stress levels on both models and their abutments within physiological limits. Conclusion. Having analyzed stresses under same conditions, we concluded that the unilateral RPD and classical RPD have similar physiological values.

  8. Partial dehydration and cryopreservation of Citrus seeds.

    Science.gov (United States)

    Graiver, Natalia; Califano, Alicia; Zaritzky, Noemí

    2011-11-01

    Three categories of seed storage behavior are generally recognized among plant species: orthodox, intermediate and recalcitrant. Intermediate seeds cannot be stored in liquid nitrogen (LN) without a previous partial dehydration process. The water content (WC) of the seeds at the moment of immersion in LN must be regarded as the most critical factor in cryopreservation. The purpose of this study was to investigate the basis of the optimal hydration status for cryopreservation of Citrus seeds: C. sinensis (sweet orange), C. paradisi (grapefruit), C. reticulata (mandarin) in LN. To study the tolerance to dehydration and LN exposure, seeds were desiccated by equilibration at relative humidities between 11 and 95%. Sorption isotherms were determined and modeled; lipid content of the seeds was measured. Seed desiccation sensitivity was quantified by the quantal response model. Differential scanning calorimetry (DSC) thermograms were determined on cotyledon tissue at different moisture contents to measure ice melting enthalpies and unfrozen WC. Samples of total seed lipid extract were also analyzed by DSC to identify lipid transitions in the thermograms. The limit of hydration for LN Citrus seeds treatment corresponded to the unfrozen WC in the tissue, confirming that seed survival strictly depended on avoidance of intracellular ice formation. Copyright © 2011 Society of Chemical Industry.

  9. Silymarin Accelerates Liver Regeneration after Partial Hepatectomy

    Directory of Open Access Journals (Sweden)

    Jia-Ping Wu

    2015-01-01

    Full Text Available Partial hepatectomy (PHx is a liver regeneration physiological response induced to maintain homeostasis. Liver regeneration evolved presumably to protect wild animals from catastrophic liver loss caused by toxins or tissue injury. Silymarin (Sm ability to stimulate liver regeneration has been an object of curiosity for many years. Silymarin has been investigated for use as an antioxidant and anticarcinogen. However, its use as a supportive treatment for liver damage is elusive. In this study, we fed silymarin (Sm, 25 mg/kg to male Sprague-Dawley rats for 7 weeks. Surgical 2/3 PHx was then conducted on the rats at 6 hrs, 24 hrs, and 72 hrs. Western blot and RT-PCR were conducted to detect the cell cycle activities and silymarin effects on hepatic regeneration. The results showed that silymarin enhanced liver regeneration by accelerating the cell cycle in PHx liver. Silymarin led to increased G1 phase (cyclin D1/pRb, S phase (cyclin E/E2F, G2 phase (cyclin B, and M phase (cyclin A protein and mRNA at 6 hrs, 24 hrs, and 72 hrs PHx. HGF, TGFα, and TGFβ1 growth factor expressions were also enhanced. We suggest that silymarin plays a crucial role in accelerated liver regeneration after PHx.

  10. CpG island methylator phenotype in adenocarcinomas from the digestive tract: Methods, conclusions, and controversies

    Science.gov (United States)

    Sánchez-Vega, Francisco; Gotea, Valer; Chen, Yun-Ching; Elnitski, Laura

    2017-01-01

    Over the last two decades, cancer-related alterations in DNA methylation that regulate transcription have been reported for a variety of tumors of the gastrointestinal tract. Due to its relevance for translational research, great emphasis has been placed on the analysis and molecular characterization of the CpG island methylator phenotype (CIMP), defined as widespread hypermethylation of CpG islands in clinically distinct subsets of cancer patients. Here, we present an overview of previous work in this field and also explore some open questions using cross-platform data for esophageal, gastric, and colorectal adenocarcinomas from The Cancer Genome Atlas. We provide a data-driven, pan-gastrointestinal stratification of individual samples based on CIMP status and we investigate correlations with oncogenic alterations, including somatic mutations and epigenetic silencing of tumor suppressor genes. Besides known events in CIMP such as BRAF V600E mutation, CDKN2A silencing or MLH1 inactivation, we discuss the potential role of emerging actors such as Wnt pathway deregulation through truncating mutations in RNF43 and epigenetic silencing of WIF1. Our results highlight the existence of molecular similarities that are superimposed over a larger backbone of tissue-specific features and can be exploited to reduce heterogeneity of response in clinical trials. PMID:28344746

  11. Advanced thermal-hydraulic and neutronic codes: current and future applications. Summary and conclusions

    International Nuclear Information System (INIS)

    2001-05-01

    An OECD Workshop on Advanced Thermal-Hydraulic and Neutronic Codes Applications was held from 10 to 13 April 2000, in Barcelona, Spain, sponsored by the Committee on the Safety of Nuclear Installations (CSNI) of the OECD Nuclear Energy Agency (NEA). It was organised in collaboration with the Spanish Nuclear Safety Council (CSN) and hosted by CSN and the Polytechnic University of Catalonia (UPC) in collaboration with the Spanish Electricity Association (UNESA). The objectives of the Workshop were to review the developments since the previous CSNI Workshop held in Annapolis [NEA/CSNI/ R(97)4; NUREG/CP-0159], to analyse the present status of maturity and remnant needs of thermal-hydraulic (TH) and neutronic system codes and methods, and finally to evaluate the role of these tools in the evolving regulatory environment. The Technical Sessions and Discussion Sessions covered the following topics: - Regulatory requirements for Best-Estimate (BE) code assessment; - Application of TH and neutronic codes for current safety issues; - Uncertainty analysis; - Needs for integral plant transient and accident analysis; - Simulators and fast running codes; - Advances in next generation TH and neutronic codes; - Future trends in physical modeling; - Long term plans for development of advanced codes. The focus of the Workshop was on system codes. An incursion was made, however, in the new field of applying Computational Fluid Dynamic (CFD) codes to nuclear safety analysis. As a general conclusion, the Barcelona Workshop can be considered representative of the progress towards the targets marked at Annapolis almost four years ago. The Annapolis Workshop had identified areas where further development and specific improvements were needed, among them: multi-field models, transport of interfacial area, 2D and 3D thermal-hydraulics, 3-D neutronics consistent with level of details of thermal-hydraulics. Recommendations issued at Annapolis included: developing small pilot/test codes for

  12. LEAping to conclusions: A computational reanalysis of late embryogenesis abundant proteins and their possible roles

    Directory of Open Access Journals (Sweden)

    Wise Michael J

    2003-10-01

    Full Text Available Abstract Background The late embryogenesis abundant (LEA proteins cover a number of loosely related groups of proteins, originally found in plants but now being found in non-plant species. Their precise function is unknown, though considerable evidence suggests that LEA proteins are involved in desiccation resistance. Using a number of statistically-based bioinformatics tools the classification of a large set of LEA proteins, covering all Groups, is reexamined together with some previous findings. Searches based on peptide composition return proteins with similar composition to different LEA Groups; keyword clustering is then applied to reveal keywords and phrases suggestive of the Groups' properties. Results Previous research has suggested that glycine is characteristic of LEA proteins, but it is only highly over-represented in Groups 1 and 2, while alanine, thought characteristic of Group 2, is over-represented in Group 3, 4 and 6 but under-represented in Groups 1 and 2. However, for LEA Groups 1 2 and 3 it is shown that glutamine is very significantly over-represented, while cysteine, phenylalanine, isoleucine, leucine and tryptophan are significantly under-represented. There is also evidence that the Group 4 LEA proteins are more appropriately redistributed to Group 2 and Group 3. Similarly, Group 5 is better found among the Group 3 LEA proteins. Conclusions There is evidence that Group 2 and Group 3 LEA proteins, though distinct, might be related. This relationship is also evident in the overlapping sets of keywords for the two Groups, emphasising alpha-helical structure and, at a larger scale, filaments, all of which fits well with experimental evidence that proteins from both Groups are natively unstructured, but become structured under stress conditions. The keywords support localisation of LEA proteins both in the nucleus and associated with the cytoskeleton, and a mode of action similar to chaperones, perhaps the cold shock chaperones

  13. Summary of the workshop robustness of electrical systems - Conclusions and recommendations

    International Nuclear Information System (INIS)

    2015-01-01

    The workshop included an opening session, seven sessions with participant presentations followed by short discussions, and a facilitated discussion session. The contributions presented were devoted to discussions of national post-Fukushima regulatory programme developments, methods to determine allowable coping time for electric power recovery, electric power system simulation methods development and benchmarking efforts, analysis of component capability, and approaches to facilitate electric power system recovery from extended loss of AC power. The following conclusions and recommendations are made based on workshop presentations, discussions during particular sessions, and facilitated discussions: - Based upon the panel discussions at the end of the workshop, a majority of the participants suggested the need for continuing efforts after the ROBELSYS workshop and particularly the importance of launching a more permanent international working group on modeling tools and methods related to nuclear power plant electrical power system studies. The working group would be modelled on WGRISK. (It is recognized that creating such a permanent working group would require a multi-year commitment of CSNI and the participants). - It will be very beneficial to continue international information sharing of the following items, eventually leading to development of suitable international electrical standards: System and component requirements for addressing beyond design basis external events; Recommended practice for incorporating diversity in the onsite electrical power system; Recommended practice for relaxing electric power protection features used in emergency situations (assuring margin against spurious electrical shutdowns); Recommended practice for qualification requirements for existing systems and portable components used to cope with AC station blackout. - There is a need for further development and improvements in the analysis and simulation of the following

  14. A note on monotonicity of item response functions for ordered polytomous item response theory models.

    Science.gov (United States)

    Kang, Hyeon-Ah; Su, Ya-Hui; Chang, Hua-Hua

    2018-03-08

    A monotone relationship between a true score (τ) and a latent trait level (θ) has been a key assumption for many psychometric applications. The monotonicity property in dichotomous response models is evident as a result of a transformation via a test characteristic curve. Monotonicity in polytomous models, in contrast, is not immediately obvious because item response functions are determined by a set of response category curves, which are conceivably non-monotonic in θ. The purpose of the present note is to demonstrate strict monotonicity in ordered polytomous item response models. Five models that are widely used in operational assessments are considered for proof: the generalized partial credit model (Muraki, 1992, Applied Psychological Measurement, 16, 159), the nominal model (Bock, 1972, Psychometrika, 37, 29), the partial credit model (Masters, 1982, Psychometrika, 47, 147), the rating scale model (Andrich, 1978, Psychometrika, 43, 561), and the graded response model (Samejima, 1972, A general model for free-response data (Psychometric Monograph no. 18). Psychometric Society, Richmond). The study asserts that the item response functions in these models strictly increase in θ and thus there exists strict monotonicity between τ and θ under certain specified conditions. This conclusion validates the practice of customarily using τ in place of θ in applied settings and provides theoretical grounds for one-to-one transformations between the two scales. © 2018 The British Psychological Society.

  15. A Partial Equilibrium Theory for Drops and Capillary Liquids

    International Nuclear Information System (INIS)

    Searcy, Alan W.; Beruto, Dario T.; Barberis, Fabrizio

    2006-01-01

    The two-century old theory of Young and Laplace retains a powerful influence on surface and interface studies because it quantitatively predicts the height of rise of capillary liquids from the contact angles of drops. But the classical theory does not acknowledge that equilibrium requires separate minimization of partial free energies of one-component liquids bonded to immiscible solids. We generalize a theorem of Gibbs and Curie to obtain a partial equilibrium (PE) theory that does so and that also predicts the height of capillary rise from contact angles of drops. Published observations and our own measurements of contact angles of water bonded to glass and Teflon surfaces support the conclusion of PE theory that contact angles of meniscuses and of drops are different dependent variables. PE theory provides thermodynamic and kinetic guidance to nanoscale processes that the classical theory obscures, as illustrated by examples in our concluding section

  16. Chester 2, Summary and Way Forward, Plenary Session Outputs, Summary Presentation and Conclusions

    International Nuclear Information System (INIS)

    2012-01-01

    The workshop ended with a summary session. The Workshop Chair and Technical Reporter summarised the main findings, and provided the opportunity for further discussion and comment. There was a discussion on the way forward, including reporting, future meetings and other means of networking. Participants provided feedback on the workshop to assist with the planning and conduct of future events. The main conclusions arising from the workshop were as follows: - Licensees are generally positive about engaging with regulators to raise awareness about and support improvements in LMfS/SC. - More active and visible senior regulatory leadership increases the effectiveness of LMfS/SC interventions. Examples of practical actions that senior regulatory leaders can take include raising LMfS/SC matters at senior levels within licensee organisations and feeding back results of discussions to regulatory staff so that priorities and expectations are aligned. - A common 'language', and trust between regulators and licensees are fundamental factors for effective oversight of LMfS/SC. - The message from the previous workshop in 2007 on the importance of integrating LMfS/SC into normal regulatory business was reinforced. - A combination of integrated and targeted LMfS/SC interventions is considered to be effective to take account of the advantages and disadvantages of both approaches. - In line with the conclusions from the previous workshop, influence is preferred to 'enforcement'. Where enforcement action is required, this is likely to be associated with tangible manifestations of LMfS/SC safety culture issues, such as license condition violations. - A fundamental principle of regulatory oversight of LMfS/SC is to encourage licensees to understand and take ownership of issues and solutions. Strategies include: Discussion of regulatory perceptions to test for shared regulator/licensee understanding, - Working together with licensees to develop guidance and understanding (e.g., through

  17. Adaptation and Employment of Special Groups of Manpower. Implementing an Active Manpower Policy; Conclusions of the Manpower and Social Affairs Committee.

    Science.gov (United States)

    Organisation for Economic Cooperation and Development, Paris (France).

    Conclusions are presented indicating the role which public bodies, employers, trade unions, and other private groups can play in improving the employment opportunities of special groups, such as older workers, workers with family responsibilities, and workers of rural origin engaged in non-agricultural employment. Because of the increasing number…

  18. Conclusions of the specialist meeting on operator AIDS for severe accident management and training (SAMOA)

    International Nuclear Information System (INIS)

    1994-01-01

    The scope of the Specialist Meeting was limited to operator aids for accident management which were in operation or could be soon. Moreover, the meeting concentrated on the management of accidents beyond the design basis, including tools which might be extended from the design basis range into the severe accident area. Relevant simulation tools for operator training were also part of the scope of the meeting. The presentations showed that the design and implementation of operator aids were closely related to the organisation adopted by the user, whether it was a utility or a governmental agency. The most common organisation is to share the management of severe accidents among two groups of people: the operating team in the Control Room (CR) and a team of specialists in a Technical Support Centre (TSC). The CR is in charge of the operation of the plant in all conditions using a set of procedures and guidelines, while the experts in the TSC are able to produce in-depth analyses of the plant state and its evolution. The responsibility is shared between the CR and the TSC during accident progression. The TSC acts as a support for the CR for reactor operation and takes charge of the predictions of radioactive releases (source term, accident progression, release and dispersion of radioactive substances, as well as the interaction with public authorities). But this type of organisation is not general and the differences can induce different approaches in the design of operator aids. The first session was dedicated to operator aids for control rooms, the second session to operator aids for technical support centres

  19. Severe accident management (SAM), operator training and instrumentation capabilities - Summary and conclusions

    International Nuclear Information System (INIS)

    2002-01-01

    The Workshop on Operator Training for Severe Accident Management (SAM) and Instrumentation Capabilities During Severe Accidents was organised in collaboration with Electricite de France (Service Etudes et Projets Thermiques et Nucleaires). There were 34 participants, representing thirteen OECD Member countries, the Russian Federation and the OECD/NEA. Almost half the participants represented utilities. The second largest group was regulatory authorities and their technical support organisations. Basically, the Workshop was a follow-up to the 1997 Second Specialist Meeting on Operator Aids for Severe Accident Management (SAMOA-2) [Reports NEA/CSNI/R(97)10 and 27] and to the 1992 Specialist Meeting on Instrumentation to Manage Severe Accidents [Reports NEA/CSNI/R(92)11 and (93)3]. It was aimed at sharing and comparing progress made and experience gained from these two meetings, emphasizing practical lessons learnt during training or incidents as well as feedback from instrumentation capability assessment. The objectives of the Workshop were therefore: - to exchange information on recent and current activities in the area of operator training for SAM, and lessons learnt during the management of real incidents ('operator' is defined hear as all personnel involved in SAM); - to compare capabilities and use of instrumentation available during severe accidents; - to monitor progress made; - to identify and discuss differences between approaches relevant to reactor safety; - and to make recommendations to the Working Group on the Analysis and Management of Accidents and the CSNI (GAMA). The Workshop was organised into five sessions: - 1: Introduction; - 2: Tools and Methods; - 3: Training Programmes and Experience; - 4: SAM Organisation Efficiency; - 5: Instrumentation Capabilities. It was concluded by a Panel and General Discussion. This report presents the summary and conclusions: the meeting confirmed that only limited information is needed for making required decisions

  20. The Successful Conclusion of the Deep Space 1 Mission: Important Results without a Flashy Title

    Science.gov (United States)

    Rayman, Marc D.

    2002-01-01

    direct scientific return, the comet encounter is of engineering value to other missions planning comet encounters. With the successful conclusion of its extended mission, DS1 undertook a hyperextended mission. This phase of its flight was dedicated to final testing of the advanced technologies on board. With the mission at more than three times its planned lifetime, this offered an excellent opportunity to obtain unplanned data on the effects of long-term operation in space. All nine of the hardware technologies were used during the hyperextended mission, with a focus on the ion propulsion system. Following this period of extremely aggressive testing, with no further technology or science objectives, the mission was terminated on December 18, 2001, with the powering off of the spacecraft s transmitter, although the receiver was left on. By the end of its mission, DS1 had returned a wealth of important science data and engineering data for future missions. It did so following the shortest time from pre-phase A through launch of any NASA interplanetary mission in the modern era and the lowest cost of any NASA interplanetary mission ever conducted (measured in same year dollars, including the launch cost). This paper will describe the encounter with comet Borrelly, the hyperextended mission, and summarize the overall results of the Deep Space 1 project.