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Sample records for parisian french pf

  1. Appropriating Written French: Literacy Practices in a Parisian Elementary Classroom

    Science.gov (United States)

    Rockwell, Elsie

    2012-01-01

    In this article, I examine French language instruction in an elementary classroom serving primarily children of Afro-French immigrants in Paris. I show that a prevalent French language ideology privileges written over oral expression and associates full mastery of written French with rational thought and full inclusion in the French polity. This…

  2. French of the present and the past: the representation of the Parisian vernacular in Maurice Chevalier's songs

    Directory of Open Access Journals (Sweden)

    Abecassis, Michaël

    2005-01-01

    Full Text Available Today in France, there seems to be a resurgence of interest in 1930s French culture, with the release of Le Fabuleux destin d'Amélie Poulain (2001, set in Montmartre, and Patrick Bruel's re-edition of 1930s popular songs (2002. Songs of the 1930s and 1940s have hardly been exploited by linguists. I have compiled a corpus of Maurice Chevalier's songs whose lexical items I have analysed to assess how language has evolved. The stereotypical representation of the lower class which was a popular theme in musical-hall songs at that time enables the analysis of vernacular forms used at the beginning of the 20th century. I willendeavour in this analysis to establish the change in attitudes towardsthe standard and stigmatised language varieties in France by looking at lexicographers' labelling of non-standard items with stylistic indicators such as familier, populaire and argotique. I also intend to gauge through a survey conducted recently in France whether the once denigrated français populaire found in Chevalier's songs is obsolete or whether it is still used in the 21st century.

  3. On-line fission products measurements during a PWR severe accident: the French DECA-PF project

    Energy Technology Data Exchange (ETDEWEB)

    Ducros, G.; Allinei, P.G.; Roure, C. [CEA, DEN, F-13108 Saint-Paul-lez-Durance, (France); Rozel, C. [EDF SEPTEN, 12-14 Avenue Dutrievoz, F-69628, Villeurbanne, (France); Blanc De Lanaute, N. [CANBERRA, 1 rue des Herons, F-78182, Saint Quentin en Yvelines, (France); Musoyan, G. [AREVA, Tour AREVA, 1 place Jean Millier, F-92084 Paris La Defense Cedex, (France)

    2015-07-01

    Following the Fukushima accident, a lot of recommendations was drawn by international organizations (IAEA, OECD, NUGENIA network...) in order to improve the safety in such accidental conditions and mitigate their consequences. One of these recommendations was to improve the robustness of the instrumentation, which was dramatically lacking at Fukushima, as well as to better determine the Source Term involved in nuclear accident. The DECA-PF project (Diagnosis of a degraded reactor core through Fission Product measurements) was elaborated in this context and selected as one of 21 collaborative R and D projects in the field of nuclear safety and radioprotection, funded in May 2013 by the French National Research Agency. Over the months following the Fukushima accident, a CEA crisis team was held in order to analyze on-line the situation taking into account the data delivered by TEPCO and other organizations. Despite the difficulties encountered concerning the reliability of these data, the work performed showed the high capacity of Fission Products (FP) measurements to get a diagnosis relative to the status of the reactors and the spent fuel pools (SFP). Based on these FP measurements, it was possible to conclude that the main origin of the releases was coming from the cores and not from the SFP, in particular for SFP-4 which was of high concern, and that the degradation level of the reactors was very large, including probably an extensive core melting. To improve the reliability of this kind of diagnosis, the necessity to get such measurements as soon as possible after the accident and as near as possible from the reactor was stressed. In this way the present DECA-PF project intends to develop a new and innovative instrumentation taking into account the design of the French nuclear power plants on which sand bed filters have been implemented for severe accident management. Three complementary techniques, devoted to measure the FP release on-line, are being studied

  4. The Parisian basin, birthplace of geothermics

    International Nuclear Information System (INIS)

    Jeanson, E.

    1995-01-01

    The exploitation of low energy geothermics in France is mainly localized in the Parisian Basin. About 40 geothermal plants are established in urbanized areas for heating and sanitary hot water supplies and also for air conditioning. Each plant can supply about 2500 to 5000 lodgings of collective buildings. Excluding drilling costs, urban investments can reach 70% of the total operating cost. Most of the exploitations draw the geothermal fluids from the Dogger reservoir located at a 1500-2000 m depth using double-well technique. Water temperature is about 60 to 85 C and solutes (salts and sulfides) represent 15 to 35 g/l. The deeper Albian and Neocomian drinking water reservoirs are exceptionally used due to their strategic nature. The corrosion problems and the age of the installations are the principal problems of the existing installations but the operating costs remain competitive with other energy sources. (J.S.). 3 figs., 9 photos

  5. Cross-language categorization of French and German vowels by naïve American listeners

    Science.gov (United States)

    Strange, Winifred; Levy, Erika S.; Law, Franzo F.

    2009-01-01

    American English (AE) speakers’ perceptual assimilation of 14 North German (NG) and 9 Parisian French (PF) vowels was examined in two studies using citation-form disyllables (study 1) and sentences with vowels surrounded by labial and alveolar consonants in multisyllabic nonsense words (study 2). Listeners categorized multiple tokens of each NG and PF vowel as most similar to selected AE vowels and rated their category “goodness” on a nine-point Likert scale. Front, rounded vowels were assimilated primarily to back AE vowels, despite their acoustic similarity to front AE vowels. In study 1, they were considered poorer exemplars of AE vowels than were NG and PF back, rounded vowels; in study 2, front and back, rounded vowels were perceived as similar to each other. Assimilation of some front, unrounded and back, rounded NG and PF vowels varied with language, speaking style, and consonantal context. Differences in perceived similarity often could not be predicted from context-specific cross-language spectral similarities. Results suggest that listeners can access context-specific, phonetic details when listening to citation-form materials, but assimilate non-native vowels on the basis of context-independent phonological equivalence categories when processing continuous speech. Results are interpreted within the Automatic Selective Perception model of speech perception. PMID:19739759

  6. Cross-language categorization of French and German vowels by naive American listeners.

    Science.gov (United States)

    Strange, Winifred; Levy, Erika S; Law, Franzo F

    2009-09-01

    American English (AE) speakers' perceptual assimilation of 14 North German (NG) and 9 Parisian French (PF) vowels was examined in two studies using citation-form disyllables (study 1) and sentences with vowels surrounded by labial and alveolar consonants in multisyllabic nonsense words (study 2). Listeners categorized multiple tokens of each NG and PF vowel as most similar to selected AE vowels and rated their category "goodness" on a nine-point Likert scale. Front, rounded vowels were assimilated primarily to back AE vowels, despite their acoustic similarity to front AE vowels. In study 1, they were considered poorer exemplars of AE vowels than were NG and PF back, rounded vowels; in study 2, front and back, rounded vowels were perceived as similar to each other. Assimilation of some front, unrounded and back, rounded NG and PF vowels varied with language, speaking style, and consonantal context. Differences in perceived similarity often could not be predicted from context-specific cross-language spectral similarities. Results suggest that listeners can access context-specific, phonetic details when listening to citation-form materials, but assimilate non-native vowels on the basis of context-independent phonological equivalence categories when processing continuous speech. Results are interpreted within the Automatic Selective Perception model of speech perception.

  7. Parisian ruin for the dual risk process in discrete-time

    OpenAIRE

    Palmowski, Zbigniew; Ramsden, Lewis; Papaioannou, Apostolos D.

    2017-01-01

    In this paper we consider the Parisian ruin probabilities for the dual risk model in a discrete-time setting. By exploiting the strong Markov property of the risk process we derive a recursive expression for the fnite-time Parisian ruin probability, in terms of classic discrete-time dual ruin probabilities. Moreover, we obtain an explicit expression for the corresponding infnite-time Parisian ruin probability as a limiting case. In order to obtain more analytic results, we employ a conditioni...

  8. Do 11-Month-Old French Infants Process Articles?

    Science.gov (United States)

    Halle, Pierre A.; Durand, Catherine; de Boysson-Bardies, Benedicte

    2008-01-01

    The first part of this study examined (Parisian) French-learning 11-month-old infants' recognition of the six definite and indefinite French articles: "le", "la", "les", "un", "une", and "des". The six articles were compared with pseudoarticles in the context of disyllabic or monosyllabic…

  9. Normative Study of Rorschach (Parisian School for Brazilian Adolescents

    Directory of Open Access Journals (Sweden)

    Maria Luísa Casillo Jardim-Maran

    2015-12-01

    Full Text Available ABSTRACTAmong the projective methods of psychological assessment, the relevance of the Rorschach method stands out in the investigation of personality, albeit without normative references in the Parisian School for adolescents in Brazil. This study addresses this gap by developing normative standards of the Rorschach method (Parisian School for this age group, evaluating specificities of production associated with sex, age and school system. The Rorschach tests were individually administered to 180 students aged from 15 to 17 years old, with typical signs of development. Data considering the 54 Rorschach's variables were descriptively and inferentially examined. The main average results were: (a productivity: R = 17.7; (b modes of apperception: G = 35.0%, D = 33.4%, Dd = 30.3% and Dd = 1.1%; (c determinants and formal indexes: F% = 54.5%, F+% = 55.6% and F+ext% = 57.3%; (d predominant content: A% = 51.0% and H% = 20.9%; (e Ban = 17.0%. Specificities of production according to sex, age and school system were identified, which supports the analysis and interpretation of Rorschach's variables with contemporary Brazilian adolescents.

  10. The Microscope against Cell Theory: Cancer Research in Nineteenth-Century Parisian Anatomical Pathology.

    Science.gov (United States)

    Loison, Laurent

    2016-07-01

    This paper examines the reception of cell theory in the field of French anatomical pathology. This reception is studied under the lens of the concept of the cancer cell, which was developed in Paris in the 1840s. In the medical field, cell theory was quickly accessible, understood, and discussed. In the wake of research by Hermann Lebert, the cancer cell concept was supported by a wealth of high-quality microscopic observations. The concept was constructed in opposition to cell theory, which appears retrospectively paradoxical and surprising. Indeed, the biological atomism inherent in cell theory, according to which the cell is the elementary unit of all organs of living bodies, appeared at the time incompatible with the possible existence of pathological cells without equivalent in healthy tissues. Thus, the postulate of atomism was used as an argument by Parisian clinicians who denied the value of the cancer cell. This study shows that at least in the field of anatomical pathology, cell theory did not directly result from the use of the microscope but was actually hindered by it. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  11. Exercise dependence among customers from a Parisian sport shop.

    Science.gov (United States)

    Lejoyeux, Michel; Guillot, Cecilia; Chalvin, Florence; Petit, Aymeric; Lequen, Valerie

    2012-03-01

    We assessed exercise dependence (ED), alcohol and nicotine use disorders, eating disorders, hypochondria and compulsive buying and in a population of customers of a Parisian sport shop. Five hundred consecutive customers of a sport shop were invited to participate. Diagnostic of exercise dependence was made with the Exercise Addiction Inventory and a specific questionnaire checking all diagnostic criteria. The DSM-IV-TR criteria for bulimia, alcohol and nicotine use disorders were checked and all subjects answered the CAGE and Fagerström questionnaires. Hypochondria was assessed with the DSM-IV-TR criteria and the Whiteley Index of Health Anxiety. For all parameters, customers with (ED+) and without (ED-) exercise dependence were compared. The prevalence of exercise dependence was 29.6%. Subjects from the ED+ group were younger than in the ED-group (27.1 vs 29.8 years) and there were more women. They were more dependent on alcohol, had higher scores at the CAGE questionnaire. ED+ subjects more often presented hypochondria (23 vs 15%), bulimia and binge eating and they more often made gifts to themselves and to others. Exercise dependence appears as a frequent and almost always unrecognized form of behavioral dependence in non clinical population frequenting sport shops. It is frequently associated to chemical dependence and eating disorders.

  12. Mobile Devices, Learning and Clinical Workplaces: Medical Student Use of Smartphones in Parisian Hospitals

    Science.gov (United States)

    Phelps, Megan; Scott, Karen M.; Chauffeté-Manillier, Martine; Lenne, Frédéric; Le Jeunne, Claire

    2017-01-01

    Mobile devices are ubiquitous worldwide, including in hospitals. "Just in time" learning provided by these devices is important for students. We investigated current use of, and learning with, smartphones and other mobile devices by medical students in Parisian hospitals. A survey with quantitative and qualitative items previously used…

  13. Properties of the malarial proteins Pf2, Pf9 and PfP0, which support ...

    Indian Academy of Sciences (India)

    Properties of the malarial proteins Pf2, Pf9 and PfP0, which support their roles as immune targets. Antibodies raised to each of these proteins (or purified from immune adults) inhibit the growth of Plasmodium falciparum at the red cell invasion step. The proteins are localized on the parasite cell surface. Each protein is ...

  14. Parisian ruin probability for spectrally negative L\\'{e}vy processes

    OpenAIRE

    Ronnie Loeffen; Irmina Czarna; Zbigniew Palmowski

    2011-01-01

    In this note we give, for a spectrally negative Lévy process, a compact formula for the Parisian ruin probability, which is defined by the probability that the process exhibits an excursion below zero, with a length that exceeds a certain fixed period $r$. The formula involves only the scale function of the spectrally negative Lévy process and the distribution of the process at time $r$.

  15. Diaphasic variation and change in French pronouns

    DEFF Research Database (Denmark)

    Hansen, Anita Berit

    2013-01-01

    The French pronominal paradigm demonstrates a colloquial variation between expressing the 1st person plural as on and as nous (On est 19 dans ma classe meaning the same as Nous sommes 19 dans ma classe). This use of definite on is stigmatized by some as working class and incorrect and seen...... as a spreading feature, but seen by others as a stable stylistic ressource. The present article (inspired by Coveney 2000) investigates the speech of six young Parisians in different kinds of speech situations, in order not only to examine the possible diaphasic dimension of the on/no us alternation, but also...... to look into their other uses of on, in search of an explanation of the increasing popularity of this pronoun in French....

  16. TPX Poloidal Field (PF) power systems simulation

    International Nuclear Information System (INIS)

    Lu, E.; Bronner, G.

    1993-01-01

    This paper describes the modeling and simulation of the PF power system for the Tokamak Physics Experiment (TPX), which is required to supply pulsed DC current to the Poloidal Field (PF) superconducting coil system. An analytical model was developed to simulate the dynamics of the PF power system for any PF current scenario and thereby provide the basis for selection of PF circuit topology, in support of the major design goal of optimizing the use of the existing Tokamak Fusion Test Reactor (TFTR) facilities at the Princeton Plasma Physics Lab (PPPL)

  17. Prevalence of compulsive buying among customers of a Parisian general store.

    Science.gov (United States)

    Lejoyeux, Michel; Mathieu, Karine; Embouazza, Houcine; Huet, Françoise; Lequen, Valérie

    2007-01-01

    Compulsive buying is defined by the presence of repetitive impulsive and excessive buying, leading to personal and family distress. The objective of this study is to assess the prevalence of compulsive buying among "normal consumers" and to describe the specificities in the buying style of compulsive buyers. We tried to answer several questions. (1) Does compulsive buying occur more often during sales or periods of sales campaigns? (2) Is compulsive buying more impulsive and unplanned than normal buying? (3) Are compulsive buyers more "affectively" involved in their purchases (preference for specific brands they have a narcissistic relationship with, tendency to consider purchases as exceptional special occasions)? (4)Do women who buy compulsively use shopping Web sites and the Internet in general more than controls? We interviewed 200 women successively entering Les Galeries Lafayette, a famous Parisian department store. We diagnosed compulsive buying with standardized criteria and a specific rating scale. All subjects answered an additional questionnaire assessing their buying behavior. We also rated their duration of connection to the Web, the number of e-mails sent and received, and the time spent speaking on a cellular phone. Prevalence of compulsive buying was 32.5%. The proportion of married women was lower among compulsive buyers (66%) than in controls (85%). Compulsive buyers do not seek sales more than controls. Their decision to buy is more often made during their stay in the shop (48% vs 24%, chi(2) = 117, P vs 23.1%, P = .006). They have a higher tendency to use items less than expected (23.4% vs 14.4% in the control group, P vs 2.5%, P = .04) and consider more often their purchases as personally gratifying (44% vs 23%, P online shopping sites are longer and more frequent. They spend significantly more time than controls speaking on their cellular phones.

  18. [Organisational factors associated with the repetition of infections among children in Parisian day-care setting].

    Science.gov (United States)

    Delour, M; Caparros, N; Rufat, P; Desplanques, L; Bonnefoi, M-C; Patris, S; Brodin, M

    2006-09-01

    This study analyzes the organisational factors linked with episodes of infections in children attending child day-care setting in Paris. A sample of children who attended parisian municipal child day-care setting, stratified on the type and the size of the day-care setting, was achieved. This cohort was followed from September 2000 to June 2001. We compared the risk of repeated infections according to the type of day-care setting (family day-care or day-care centre), and for the day-care centre according to the size (60 places) and the structure of groups (mixing age groups or not). The events studied were the occurrence of at least: 6 episodes of any infection, 2 otitis, 2 gastroenteritis, 2 conjunctivitis or 5 upper respiratory tract infections. Nine hundred and ninety-three children were included in this study. The 878 children attending a day-care centre had a significant higher risk of infections compare to children in family day-care (RR = 2.92[1.58-5.38]) except for gastroenteritis and conjunctivitis. This relationship between the type of day-care setting and the repeated infections was especially shown for children younger than 1 year. The mixing of ages only increased the risk of conjunctivitis (RR = 1.98[1.15-3.42]). No significant relationship between the size of the day care centre and the repetition of every studied infection was found. This study strengthens the orientation of the more vulnerable children towards the family day-care centers.

  19. ITER PF6 double pancakes winding line

    Energy Technology Data Exchange (ETDEWEB)

    Du, Shuangsong [Institute of Plasma Physics, Chinese Academy of Science, Hefei (China); University of Science and Technology of China, Hefei (China); Wen, Wei, E-mail: wenwei@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Science, Hefei (China); Chen, Jin; Wu, Weiyue; Song, Yuntao; Shen, Guang [Institute of Plasma Physics, Chinese Academy of Science, Hefei (China)

    2017-03-15

    Highlights: • ITER PF6 double pancakes “two-in-hand” winding line layout and main parameters were introduced, main winding sequences were also included. • Main features of each winding unit include de-spooling unit, straightening unit, sandblasting and cleaning unit, bending unit, turn insulation wrapping head, rotary table and automatic control system were depicted. • PF6 double pancake winding line was commissioned with PF5 empty jacket conductor after the installation and testing of each unit, ±0.5 mm turn positioning and ±2 turn to turn deviations were achieved. - Abstract: The Poloidal Field (PF) coils are one of the main sub-systems of the ITER magnets. The PF6 coil is being manufactured by the Institute of Plasma Physics, Chinese Academy of Sciences (ASIPP) as per the Poloidal Field coils cooperation agreement signed between ASIPP and Fusion for Energy (F4E).The ITER PF6 winding pack is composed by stacking of 9 double pancakes. Each double pancake is wound with a “two-in-hand” configuration. This paper describes the ITER PF6 double pancakes winding line, including layout and main parameters of the winding line, features of main units and the commissioning trial with PF5 empty jacket conductor.

  20. Status and performance of PF injector linac

    International Nuclear Information System (INIS)

    Sato, Isamu

    1994-01-01

    PF injector linac has been improved on a buncher section for accelerating of intense electron beam, and reinforced a focusing system of the positron generator linac for the expansion of phase space. In this presentation, I shall report present status and performance of PF injector linac, and discuss its upgrade program for B-factory project. (author)

  1. Prevalence of exercise dependence and other behavioral addictions among clients of a Parisian fitness room.

    Science.gov (United States)

    Lejoyeux, Michel; Avril, Marine; Richoux, Charlotte; Embouazza, Houcine; Nivoli, Fabrizia

    2008-01-01

    Exercise dependence is an inadequate pattern of exercise leading to clinically significant negative consequences. Subjects present loss of control of their physical activity, tolerance, and withdrawal symptoms when they do not practice sport. We studied the prevalence of exercise dependence among clients of a Parisian fitness room. We also assessed alcohol and nicotine use disorders, 2 other "socially tolerated" behavioral addictions (compulsive buying and Internet addiction), and 2 disorders related to anxiety focused on the body (bulimia and hypochondria). All clients of the fitness room 18 years and older were invited to participate in the study. Three hundred subjects were included; 125 (42%) presented diagnostic criteria of exercise dependence. Unsurprisingly, exercise dependents spent more hours each day in the fitness center practicing (2.1 vs 1.5 hours per day). They went to the fitness center more often each week (3.5 vs 2.9 days per week). Exercise addicts smoked less; alcohol consumption was equivalent in both groups. Compulsive buying was significantly more frequent in exercise dependents (63% vs 38%), which means they scored higher in the compulsive buying scale (5.4 vs 4.1). Prevalence of hypochondria was equivalent in both groups, but scores in the Whiteley Index of Hypochondria were higher (4.1 vs 3) in the exercise-dependent group. Bulimia was significantly more frequent among exercise dependents (70% vs 47%), who also presented a higher number of bulimic episodes each week (2.5 vs 1.3). Subjects with exercise dependence spent more time on their computer each day (3.9 vs 2.4 hours per day). We found no difference regarding time spent using Internet, the number of e-mails sent or received, and their time at speaking on a cellular phone. Our results lead to systematically study the addictive relation to exercise among regular clients of the fitness rooms. Exercise addicts are exposed to negative consequences for their excess of physical activity

  2. Decision from the Commission of Electricity Regulation (CRE) dated from May 2, 2002 about a dispute between the manager of the power transportation network (RTE) and the autonomous administration of Parisian transports (RATP) relative to the conditions of consideration of the multiplicity of power supply points in the contractual system of access to the power grid; Decision de la Commission de Regulation de l'Electricite (CRE) en date du 2 mai 2002 sur un different qui oppose le gestionnaire du Reseau de Transport d'Electricite (RTE) et la Regie Autonome des Transports Parisiens (RATP) relatif aux conditions de prise en compte de la multiplicite des points de livraison dans le dispositif contractuel d'acces au reseau electrique

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-05-01

    This document is the analysis made by the French commission of electricity regulation (CRE) about a dispute between the French manager of the power transportation grid (RTE) and the autonomous administration of Parisian transports (RATP) about its contract of access to the grid for the power supply of the underground railway of Paris. The RATP requested a regrouping of all its 7 supply points in a single contract. After analysis of the hearings, the CRE considers that no discrimination exists in the contractual system proposed by the RTE and thus the RATP request has been rejected. (J.S.)

  3. Heitor Villa-Lobos and the Parisian art scene: how to become a Brazilian musician

    Directory of Open Access Journals (Sweden)

    Paulo Renato Guérios

    2006-01-01

    Full Text Available This article discusses how the flux of cultural productions between centre and periphery works, taking as an example the field of music production in France and Brazil in the 1920s. The life trajectories of Jean Cocteau, French poet and painter, and Heitor Villa-Lobos, a Brazilian composer, are taken as the main reference points for the discussion. The article concludes that social actors from the periphery tend themselves to accept the opinions and judgements of the social actors from the centre, taking for granted their definitions concerning the criteria that validate their productions.

  4. French Foodscapes

    DEFF Research Database (Denmark)

    Hedegaard, Liselotte

    By exploring how local and regional products and uses of food interact with the changes in the French cuisine over time, this paper seeks to retrace the history of the French meal through meanings of place and time, terroir and savoir-faire. The study will be based on sources from early modern/modern history...... the destructuralisation of eating habits have been raised since the 1980s, but numerous studies emphasise that the traditional French meal is still playing an important role in everyday life in France. Despite regional variations, the general view of the structure of a traditional French meal as based on the succession...... of flavours and the accordance with wines is widespread. Such a comprehension means giving precedence to gastronomic reasons for determining the order of dishes. However, the French meal has not always been composed in the way it is today and the reasons for the composition have not always been gastronomic...

  5. French Courses

    CERN Multimedia

    2012-01-01

    General and Professional French Courses These courses are open to all persons working on the CERN site, and to their spouses. The next session will take place from 28 January to 5 April 2013. Oral Expression This course is aimed for students with a good knowledge of French who want to enhance their speaking skills. Speaking activities will include discussions, meeting simulations, role-plays etc. The next session will take place from 28 January to 5 April 2013. Writing professional documents in French These courses are designed for non-French speakers with a very good standard of spoken French. The next session will take place from 28 January to 5 April 2013. For registration and further information on the courses, please consult our Web pages or contact Kerstin Fuhrmeister.

  6. Operational Status of PF-Ring and PF-AR after the Earthquake

    International Nuclear Information System (INIS)

    Honda, T; Asaoka, S; Haga, K; Harada, K; Honda, Y; Izawa, M; Kamiya, Y; Kobayashi, Y; Miyajima, T; Miyauchi, H; Nagahashi, S; Nakamura, N; Nogami, T; Obina, T; Ozaki, T; Sagehashi, H; Sakai, H; Sakanaka, S; Sasaki, H; Sato, Y

    2013-01-01

    In 2011, two SR sources of KEK, PF-ring and PF-AR, needed to change the operation schedule because of the unprecedented earthquake on March 11. Though the injector linac and the storage rings suffered a serious damage, temporary recovery was accomplished quickly and the trial operation started in May. The regular user operation could be resumed in October 2011. In the restoration work after the earthquake, some old vacuum components were removed from PF-ring. This work fortunately brought an effect of settling the quadrupole-mode longitudinal instability. For the top-up injection of PF-ring, the pulsed sextupole magnet has been used instead of the conventional kicker magnets since 2011. The hybrid-fill mode in place of the single-bunch mode has become available. Recently, the 10-Hz orbit switching for the tandem circularly polarized undulators has been developed for the user operation.

  7. French Training

    CERN Multimedia

    Françoise Benz

    2003-01-01

    General and Professional French Courses The next session will take place: from 13 October to 19 December 2003. These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages or contact Mrs. Fontbonne: Tel. 72844. Writing Professional Documents in French This course is designed for people with a good level of spoken French. Duration: 30 hours Price: 660 CHF (for 8 students) For further information and registration, please consult our Web pages or contact Mrs. Fontbonne: Tel. 72844. Language Training Françoise Benz Tel.73127 language.training@cern.ch

  8. Status of potential PfATP6 molecular markers for artemisinin resistance in Suriname

    Directory of Open Access Journals (Sweden)

    Adhin Malti R

    2012-09-01

    Full Text Available Abstract Background Polymorphisms within the PfATP6 gene have been indicated as potential molecular markers for artemisinin efficacy. Since 2004, the use of artemisinin combination therapy (ACT was introduced as first-line treatment of the uncomplicated malaria cases in Suriname. The aim of this research was to determine changes in Suriname in the status of the polymorphic markers in the PfATP6 gene before and after the adoption of the ACT-regimen, particularly of the S769N mutation, which was reported to be associated with in vitro Artemether resistance in the neighboring country French Guiana. Methods The PfATP6 gene from Plasmodium falciparum parasites in Suriname was investigated in 28 samples using PCR amplification and restriction enzyme analysis, to assess and determine the prevalence of potentially interesting single nucleotide polymorphisms. The polymorphisms [L263E; A623E; S769N], which may be associated with the artemisinin resistant phenotype were characterized in parasites from three endemic regions before and after the adoption of the ACT-regimen. In addition, the status of these molecular markers was compared in paired P. falciparum isolates from patients with recurring malaria after controlled ACT. Results All the investigated samples exhibit the wild-type genotype at all three positions; L263, A623, S769. Conclusion All investigated isolates before and after the adoption of the ACT-regimen and independent of endemic region harbored the wild-type genotype for the three investigated polymorphisms. The study revealed that decreased artemisinin susceptibility could occur independent from PfATP6 mutations, challenging the assumption that artemisinin resistance is associated with these mutations in the PfATP6 gene.

  9. French courses

    CERN Document Server

    HR Department

    2012-01-01

    General and Professional French Courses The next session will take place from 2nd May to 6th July 2012. These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages or contact Kerstin Fuhrmeister.   Oral Expression This course is aimed for students with a good knowledge of French who want to enhance their speaking skills. Speaking activities will include discussions, meeting simulations, role-plays etc. Suitable candidates should contact Kerstin Fuhrmeister (70896) in order to arrange an appointment for a test. The next session will take place from 2nd May to 6th July 2012.   Writing professional documents in French These courses are designed for non-French speakers with a very good standard of spoken French. Suitable candidates should contact Kerstin Fuhrmeister (70896) in order to arrange an appointment for a test. The next session will take place from 2nd May to ...

  10. French courses

    CERN Document Server

    2013-01-01

    General and Professional French Courses The next session will take place from 29 April to 5 July 2013. These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages or contact Kerstin Fuhrmeister (kerstin.fuhrmeister@cern.ch). Oral Expression This course is aimed for students with a good knowledge of French who want to enhance their speaking skills. Speaking activities will include discussions, meeting simulations, role-plays etc. Suitable candidates should contact Kerstin Fuhrmeister (70896) in order to arrange an appointment for a test. The next session will take place from 29 April to 5 July 2013. Writing professional documents in French These courses are designed for non-French speakers with a very good standard of spoken French. Suitable candidates should contact Kerstin Fuhrmeister (70896) in order to arrange an appointment for a test. The next session will take place from 29 April to 5 July...

  11. Access French

    CERN Document Server

    Grosz, Bernard

    2014-01-01

    Access is the major new language series designed with the needs of today's generation of students firmly in mind. Whether learning for leisure or business purposes or working towards a curriculum qualification, Access French is specially designed for adults of all ages and gives students a thorough grounding in all the skills required to understand, speak, read and write contemporary French from scratch. The coursebook consists of 10 units covering different topic areas, each of which includes Language Focus panels explaining the structures covered and a comprehensive glossary. Learning tips

  12. Hardware-in-the-loop simulation of the EAST PF converter for PF control system upgrade

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Xiaojiao, E-mail: chenxj@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Science (ASIPP), P.O. Box 1126, Hefei, Anhui Province 230031 (China); Chinese University of Science and Technology, Hefei, Anhui Province 230022 (China); Fu, Peng [Institute of Plasma Physics, Chinese Academy of Science (ASIPP), P.O. Box 1126, Hefei, Anhui Province 230031 (China); Chinese University of Science and Technology, Hefei, Anhui Province 230022 (China); Huang, Liansheng, E-mail: huangls@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Science (ASIPP), P.O. Box 1126, Hefei, Anhui Province 230031 (China); Gao, Ge; He, Shiying [Institute of Plasma Physics, Chinese Academy of Science (ASIPP), P.O. Box 1126, Hefei, Anhui Province 230031 (China)

    2016-11-15

    Highlights: • The hardware in the loop simulation of the EAST PF system is presented. • The control functions and the protection logic have been tested and verified. • The major faults could be avoided and commissioning time could be saved on site. - Abstract: The EAST poloidal field (PF) control system was upgraded in 2015 and the new system has been in use for the 2015 EAST campaign. This paper presents the implementation of a hardware-in-the-loop (HIL) simulation platform of the EAST PF converter system based on the RT-LAB simulation environment, which was used to improve and evaluate the performance of the real controller. The EAST PF power supply system and its operational modes are presented in this paper. The experiments on HIL simulation platform show that the control algorithms and the over current protection of the controller meet the design requirements well. In addition, the effectiveness of the designed control system has been verified by actual application during the EAST campaign at 2015 for six months.

  13. Hardware-in-the-loop simulation of the EAST PF converter for PF control system upgrade

    International Nuclear Information System (INIS)

    Chen, Xiaojiao; Fu, Peng; Huang, Liansheng; Gao, Ge; He, Shiying

    2016-01-01

    Highlights: • The hardware in the loop simulation of the EAST PF system is presented. • The control functions and the protection logic have been tested and verified. • The major faults could be avoided and commissioning time could be saved on site. - Abstract: The EAST poloidal field (PF) control system was upgraded in 2015 and the new system has been in use for the 2015 EAST campaign. This paper presents the implementation of a hardware-in-the-loop (HIL) simulation platform of the EAST PF converter system based on the RT-LAB simulation environment, which was used to improve and evaluate the performance of the real controller. The EAST PF power supply system and its operational modes are presented in this paper. The experiments on HIL simulation platform show that the control algorithms and the over current protection of the controller meet the design requirements well. In addition, the effectiveness of the designed control system has been verified by actual application during the EAST campaign at 2015 for six months.

  14. French regulations

    International Nuclear Information System (INIS)

    Ballereau, P.

    1998-01-01

    In this issue are given the new French regulations relative to radiation protection of temporary personnel, the licensing to release gaseous and liquid wastes and the licensing granted to thirty two laboratories using beta and gamma decay radioisotopes. (N.C.)

  15. Study on the pyrolysis of phenol-formaldehyde (PF) resin and modified PF resin

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Jigang, E-mail: wangjigang@seu.edu.cn [Jiangsu Key Laboratory of Advanced Metallic Materials, School of Materials Science and Engineering, Southeast University, Nanjing 211189 (China); Jiang, Haiyun [Jiangsu Key Laboratory of Advanced Metallic Materials, School of Materials Science and Engineering, Southeast University, Nanjing 211189 (China); School of Materials Science and Engineering, Southeast University, Nanjing Institute of Technology, Nanjing 210013 (China); Jiang, Nan [Institute of Theoretical and Computational Chemistry, Nanjing University, Nanjing 210093 (China)

    2009-12-10

    The pyrolysis of pure phenol-formaldehyde (PF) resin and boron carbide (B{sub 4}C) modified PF resin was investigated by using thermogravimetry (TG) and pyrolysis gas-chromatography-mass-spectrometry (PY-GC/MS). Scanning electron microscope (SEM) and Fourier transform infrared (FT-IR) spectroscopy were also employed to investigate the micro-structural evolution. It was shown from the TG analysis that the char residues of pure PF resin were 62.9 and 60.5% after being pyrolyzed at 700 and 1000 {sup o}C, respectively. The degradation and failure of the resin matrix were mainly resulted from the release of volatiles. The phenol and its methyl derivates took a large proportion in the amount of volatiles. In comparison with the pure PF resin, the char residues of B{sub 4}C modified PF resin were obviously higher, with the values of 71.9 and 68.4% at 700 and 1000 {sup o}C, respectively. Due to the oxidation-reduction reactions between B{sub 4}C additive and oxygen-containing volatiles including CO and H{sub 2}O, partial carbon and oxygen elements in the volatiles remained in the resin matrix in the forms of amorphous carbon and B{sub 2}O{sub 3}, respectively. The results of SEM and FT-IR characterization demonstrated the occurrence of the modification, and the amorphous carbon existed in the form of reticular substance. In addition, the amount of the released phenol and its methyl derivates was also decreased drastically due to the formation of borate.

  16. French Customs

    CERN Multimedia

    GS Department

    2010-01-01

    Please note that the French Customs (initially located in Building 904, Prévessin) are now located in Ferney-Voltaire (FR): Mrs Catherine NEUVILLE Douane de Ferney-Voltaire Rue de Genève F – 01210 Ferney-Voltaire Phone : 33 4 50 40 51 42 Email : catherine.neuville@douane.finances.gouv.fr Tom Wegelius Tel: 79947 Logistics and Site Services

  17. Thermal Stability of LiPF6 Salt and Li-ion Battery Electrolytes Containing LiPF6

    OpenAIRE

    Yang, Hui; Zhuang, Guorong V.; Ross Jr., Philip N.

    2006-01-01

    The thermal stability of the neat LiPF6 salt and of 1 molal solutions of LiPF6 in prototypical Li-ion battery solvents was studied with thermogravimetric analysis (TGA) and on-line FTIR. Pure LiPF6 salt is thermally stable up to 380 oK in a dry inert atmosphere, and its decomposition path is a simple dissociation producing LiF as solid and PF5 as gaseous products. In the presence of water (300 ppm) in the carrier gas, its decomposition onset temperature is lowered as a result of direct t...

  18. French visas

    CERN Multimedia

    2007-01-01

    The French Ministry of Foreign Affairs (hereinafter "MAE") has informed CERN of the following new regulations governing the visas required when submitting requests for French legitimation documents (cf. in particular paragraph b) below concerning the facilities recently granted to certain categories of persons who are not nationals of Switzerland or of a member state of the European Economic Area). This notification replaces that which appeared in Bulletin No.19/2006 (ref. CERN/DSU-DO/RH/13173/Rev.). 1. Special residence permit ("Titre de séjour special") To qualify for a special residence permit from the MAE, persons who are not nationals of Switzerland or of a member state of the European Economic Area (hereinafter "EEA") must present the following upon arrival at CERN: a)\teither a “D”-type (long-stay) French visa marked “carte PROMAE à solliciter à l’arrivée”, even if they are not subject to the requirement to obtain an entrance and short-stay visa in France...

  19. Breaking up the crowd: the litterary caricature from the French "Physiologies" to Collodi’s "Fisiologie"

    Directory of Open Access Journals (Sweden)

    Pina Paone

    2016-12-01

    Full Text Available The aim of this paper is to discuss about a particular literary genre, started in France in the XIX century: the Physiologies. We will clarify the different phases of circulation of the genre: first of all, with Brillat Savarin’s Physiologie du gout and Balzac’s Physiologie du mariage, then with the Physiologies of the petits journaux, and at last with the ‘physiologic boom’ of the years 1840-42, when the genre acquired more clearly the aim of categorize the Parisian society, by connecting the parody of natural sciences to the techniques of caricatural description. The classifying anxiety showed in these little books will be related to the epoch-making changes happened in the metropolitan Parisian context of the Modern age. Finally, we will study the passage of this French genre to Italy, and in particular on the humorous magazines, focusing mostly on Lo Scaramuccia and Il Lampione, two important magazines that Collodi founded and wrote on. We will analyze, according to the difference of context, the distance between the two models and the peculiarity of Collodi’s one, by focusing above all on the techniques of the caricatural writing, related to the complex way through which this genre conceives the idea of the “type”.

  20. French revolution or industrial revolution?

    DEFF Research Database (Denmark)

    Weisdorf, Paul R. Sharp Jacob L.; Weisdorf, Jacob Louis

    2012-01-01

    in London and Paris in the centuries leading up to 1800. Whilst in London, building workers were facing low and stable consumer prices over the period, leaving plenty of scope for a demand-driven consumer revolution (in particular after 1650), their Parisian counterparts had to engage in a year-long grind...

  1. TPX: Contractor preliminary design review. Volume 2, PF systems engineering

    International Nuclear Information System (INIS)

    Calvin, H.A.

    1995-01-01

    This system development specification covers the Poloidal Field (PF) Magnet System, WBS 14 in the Princeton Plasma Physics Laboratory TPX Program to build a tokamak fusion reactor. This specification establishes the performance, design, development and test requirements of the PF Magnet System

  2. TPX: Contractor preliminary design review. Volume 2, PF systems engineering

    Energy Technology Data Exchange (ETDEWEB)

    Calvin, H.A. [Lawrence Livermore National Lab., CA (United States)

    1995-07-28

    This system development specification covers the Poloidal Field (PF) Magnet System, WBS 14 in the Princeton Plasma Physics Laboratory TPX Program to build a tokamak fusion reactor. This specification establishes the performance, design, development and test requirements of the PF Magnet System.

  3. TRAC-PF1 choked-flow model

    International Nuclear Information System (INIS)

    Sahota, M.S.; Lime, J.F.

    1983-01-01

    The two-phase, two-component choked-flow model implemented in the latest version of the Transient Reactor analysis Code (TRAC-PF1) was developed from first principles using the characteristic analysis approach. The subcooled choked-flow model in TRAC-PF1 is a modified form of the Burnell model. This paper discusses these choked-flow models and their implementation in TRAC-PF1. comparisons using the TRAC-PF1 choked-flow models are made with the Burnell model for subcooled flow and with the homogeneous-equilibrium model (HEM) for two-phae flow. These comparisons agree well under homogeneous conditions. Generally good agreements have been obtained between the TRAC-PF1 results from models using the choking criteria and those using a fine mesh (natural choking). Code-data comparisons between the separate-effects tests of the Marviken facility and the Edwards' blowdown experiment also are favorable. 10 figures

  4. French slanguage

    CERN Document Server

    Ellis, Michael

    2012-01-01

    With this fun visual guide, simply follow the illustrated prompts and read the English words out loud: soon you'll be speaking French! Ask how someone is doing: "Comet Haley View" or say thank you very much: "Mare See Bow Cool." The simple icons are easy to follow and this pocket-sized guide is easy to carry with you. It will give you the basic phrases you need to get around while traveling, whether asking directions, ordering food at a restaurant, or shopping. But most of all, it's just plain fun!

  5. French training

    CERN Multimedia

    2007-01-01

    The next session will take place from 29 January to 30 March 2007. These courses are open to all persons working on the CERN site, and their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: tel. 73127. Writing Professional Documents in French The next session will take place from 29 January to 30 March 2007. This course is designed for people with a good level of spoken French. Duration: 30 hours Price: 660 CHF (for 8 students) For further information and registration, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: tel. 73127. Writing Professional Documents in English The next session will take place from January to June 2007 (break at Easter). This course is designed for people with a good level of spoken English. Duration: 30 hours Price: 660 CHF (for 8 students) Timetable will be fixed after discussion with the students. For further information and registration, please consu...

  6. Thermal stability of LiPF 6 salt and Li-ion battery electrolytes containing LiPF 6

    Science.gov (United States)

    Yang, Hui; Zhuang, Guorong V.; Ross, Philip N.

    The thermal stability of the neat lithium hexafluorophosphate (LiPF 6) salt and of 1 molal (m) solutions of LiPF 6 in prototypical Li-ion battery solvents was studied with thermogravimetric analysis (TGA) and on-line Fourier transform infrared (FTIR). Pure LiPF 6 salt is thermally stable up to 107 °C in a dry inert atmosphere, and its decomposition path is a simple dissociation producing lithium fluoride (LiF) as solid and PF 5 as gaseous products. In the presence of water (300 ppm) in the carrier gas, its decomposition onset temperature is lowered as a result of direct thermal reaction between LiPF 6 and water vapor to form phosphorous oxyfluoride (POF 3) and hydrofluoric acid (HF). No new products were observed in 1 m solutions of LiPF 6 in ethylene carbonate (EC), dimethyl carbonate (DMC) and ethyl methyl carbonate (EMC) by on-line TGA-FTIR analysis. The storage of the same solutions in sealed containers at 85 °C for 300-420 h did not produce any significant quantity of new products as well. In particular, no alkylflurophosphates were found in the solutions after storage at elevated temperature. In the absence of either an impurity like alcohol or cathode active material that may (or may not) act as a catalyst, there is no evidence of thermally induced reaction between LiPF 6 and the prototypical Li-ion battery solvents EC, PC, DMC or EMC.

  7. KT-2 poloidal-field(PF) system design

    Energy Technology Data Exchange (ETDEWEB)

    Han, Jang Min; Hong, Bong Keun; Hwang, Chul Kyu; Song, Woo Sub; Kim, Sung Kyu; Lee, Kwang Won [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1995-12-01

    KT-2 poloidal-field (PF) system design is described. The PF coil system is designed for both up-down symmetric double-null (DN) and up-down asymmetric single-null (SN) configurations. Three sets of `design-basis` scenarios, which describe the ohmic heating (OH), the 5MW and the high bootstrap (HIBS) baseline modes, are represented. In these cases, the power and energy required from external power supplies are calculated. 8 tabs., 54 figs., 14 refs. (Author).

  8. French Teaching Aids.

    Science.gov (United States)

    Miller, J. Dale

    Supplementary teaching materials for French language programs are presented in this text. Primarily intended for secondary school students, the study contains seven units of material. They include: (1) French gestures, (2) teaching the interrogative pronouns, (3) French cuisine, (4) recreational learning games, (5) French-English cognates, (6)…

  9. Resilience of sewage services to climate change uncertainty: analysis of the management of sewer overflows in two Parisian suburban areas.

    Science.gov (United States)

    Rioust, E.; Deroubaix, J. F.; Barroca, B.; Bonierbale, T.; de Gouvello, B.; Deutsch, J. C.; Hubert, G.

    2009-04-01

    This paper considers the resilience perspective as an approach for understanding social and political vulnerabilities of urban services. The authors examine to what extend uncertainty due to climate change may affect the resilience of these urban services. The resilience perspective is increasingly used for analysing social groups' capacities to adapt to and live with disturbances. A lot of work on resilience has focused on the capacity to absorb shocks and still maintain functions. But there is also another aspect of resilience, which leads to take into account systems vulnerabilities and to aim at understanding their equilibrium and re-organization capacity. The purpose with this paper is to assess sewage systems capacities to adapt to climate change. Indeed, climate change could cause an increase of extreme rain events and, as a matter of consequence, an increase of sewer overflows and flooding of urbanised areas. Sewer systems have to cope with this change that may gravely affect urban planning. In recent studies of political science, risk management has been considered as a public policy involving and resulting from complex social, political and technical processes (Gilbert et al. 2003). From this point of view, the management of wastewaters and storm waters has to be considered not only as a technical but also as a political and a social system. Therefore, political science can be a fruitful perspective to understand the stakeholders perceptions of uncertainty and the way they are going to integrate this issue in their practices. The authors analyse the adaptive capacities of two sewer systems located in the Parisian suburban area. The chosen areas are highly populated. Each network is managed within a political and administrative unit called "Département". Both authorities of these "Départements" implement a public sewage service. Nonetheless these networks are connected and part of the greater Paris sewage policy. In both areas a real time control of

  10. EPICOR-II resin degradation results from first resin samples of PF-8 and PF-20

    International Nuclear Information System (INIS)

    McConnell, J.W. Jr.; Sanders, R.D. Sr.

    1985-12-01

    The 28 March 1979 accident at Three Mile Island Unit 2 released approximately 560,000 gallons of contaminated water to the Auxiliary and Fuel Handling Buildings. The water was decontaminated using a demineralization system called EPICOR-II developed by Epicor, Inc. The Low-Level Waste Data Base Development - EPICOR-II Resin/Liner Investigation Project is studying the chemical and physical conditions of the synthetic ion exchange resins found in several EPICOR-II prefilters. This report summarizes results and analyses of the first sampling of ion exchange resins from EPICOR-II prefilters PE-8 and -20. Results are compared with baseline data from tests performed on unirradiated Epicor, Inc. resins to determine if degradation has occurred due to the high internal radiation dose received by the EPICOR-II resins. Results also are compared with recent findings on resin degradation by Battelle Columbus Laboratories and Brookhaven National Laboratory. Analyses comparing test results of resins from EPICOR-II prefilters PF-8 and -20 with unirradiated resins obtained from Epicor, Inc. show resin degradation has occurred in some of the EPICOR-II resins examined. The mechanism of degradation is compared with work of other researchers and is consistent with their findings. The strong acid cation resins (divinylbenzene, styrene base structure) are losing effective cross-linking along with scission of functional groups and are experiencing first an increase and eventually a decrease in total exchange capacity as the absorbed radiation dose increases. The phenolic cation resins (phenol-formaldehyde base structure) show a loss of effective cross-linking and oxidation of the polymer chain. Analyses of resins removed from EPICOR-II prefilters PF-8 and -20 over the next several years should show a further increase in degradation

  11. 21PF overpacks: Phenolic-foam induced corrosion

    International Nuclear Information System (INIS)

    Kovac, F.M.

    1994-01-01

    The 21PF overpack was developed in the 1960s and approved for use in the 1970s by the US Department of Transportation (DOT). This package, used for the transport of uranium hexafluoride enriched >1%, has had a history of severe metal corrosion, water ingress, and subsequent leakage. Problems associated with corrosion and water leaking from 21PF overpacks caused the DOT to seek public comments and to undertake rulemaking action. As a result, the DOT required modifications and refurbishment of existing overpacks, and specification changes for the fabrication of new 21PF overpacks. Recent studies conducted by the roofing industry indicate that phenolic foam has caused severe corrosion in metal roofing structures, and its use is being curtailed. These findings need to be explored in order to determine if phenolic foam in 21PF overpacks causes corrosion and compromises the package integrity. Metallic corrosion induced by phenolic foam may affect the continued use of the 21PF overpack because damage to the structural integrity of the metal parts of the packaging will affect its ability to meet design specifications

  12. Hydrogen sulfide adsorption on activated carbon fiber. Tests on Parisian subway; Elimination du sulfure d'hydrogene par adsorption sur tissu de charbon actif. Essais sur site RATP

    Energy Technology Data Exchange (ETDEWEB)

    Bouzaza, A.; Marsteau, St.; Laplanche, A. [Ecole Nationale Superieure de Chimie, Lab. Chimie des Nuissances et Genie de l' Environnement - CNGE, 35 - Rennes (France); Garrot, B. [RATP, Dept. Environnement et Securite-Domaines d' Expertises de l' Environnement-Entite Qualite de l' Air, 75 - Paris (France)

    2003-06-01

    Hydrogen sulfide has an unpleasant odor and may cause damage to the electrical materials of the Parisian subway. The activated carbon has some intrinsic catalytic activity, so the removal of hydrogen sulfide is due to an adsorption-oxidation process. In a laboratory scale, some kinetic parameters were acquired, which allowed us to build up two dynamic reactors. These continuous reactors, equipped with activated carbon fibers, were tested on the Madeleine station of the Parisian subway. The feasibility of the elimination of H{sub 2}S by continuous adsorption-oxidation was confirmed. The relative humidity of the gas phase was found to play an important role in the performance of the elimination. The durability of the pilot tested was compatible with an industrial exploitation of the process. (authors)

  13. The Structure of Plasmodium falciparum Blood-Stage 6-Cys Protein Pf41 Reveals an Unexpected Intra-Domain Insertion Required for Pf12 Coordination.

    Directory of Open Access Journals (Sweden)

    Michelle L Parker

    Full Text Available Plasmodium falciparum is an apicomplexan parasite and the etiological agent of severe human malaria. The complex P. falciparum life cycle is supported by a diverse repertoire of surface proteins including the family of 6-Cys s48/45 antigens. Of these, Pf41 is localized to the surface of the blood-stage merozoite through its interaction with the glycophosphatidylinositol-anchored Pf12. Our recent structural characterization of Pf12 revealed two juxtaposed 6-Cys domains (D1 and D2. Pf41, however, contains an additional segment of 120 residues predicted to form a large spacer separating its two 6-Cys domains. To gain insight into the assembly mechanism and overall architecture of the Pf12-Pf41 complex, we first determined the 2.45 Å resolution crystal structure of Pf41 using zinc single-wavelength anomalous dispersion. Structural analysis revealed an unexpected domain organization where the Pf41 6-Cys domains are, in fact, intimately associated and the additional residues instead map predominately to an inserted domain-like region (ID located between two β-strands in D1. Notably, the ID is largely proteolyzed in the final structure suggesting inherent flexibility. To assess the contribution of the ID to complex formation, we engineered a form of Pf41 where the ID was replaced by a short glycine-serine linker and showed by isothermal titration calorimetry that binding to Pf12 was abrogated. Finally, protease protection assays showed that the proteolytic susceptibility of the ID was significantly reduced in the complex, consistent with the Pf41 ID directly engaging Pf12. Collectively, these data establish the architectural organization of Pf41 and define an essential role for the Pf41 ID in promoting assembly of the Pf12-Pf41 heterodimeric complex.

  14. French grammar for dummies

    CERN Document Server

    Mazet, Veronique

    2013-01-01

    The easy way to master French grammar French Grammar For Dummies is a logical extension and complement to the successful language learning book, French For Dummies. In plain English, it teaches you the grammatical rules of the French language, including parts of speech, sentence construction, pronouns, adjectives, punctuation, stress and verb tenses, and moods. Throughout the book, you get plenty of practice opportunities to help you on your goal of mastering basic French grammar and usage. Grasp the grammatical rules of French including parts of speech, sentenc

  15. Enacting cultural boundaries in French and German diphtheria serum research.

    Science.gov (United States)

    Klöppel, Ulrike

    2008-06-01

    The experimental development of a therapeutic serum against diphtheria between 1891 and 1894 was characterized by a scientific competition that pitted Emil Behring from the Institute for Infectious Diseases in Berlin against Emile Roux and Elie Metschnikoff from the Pasteur Institute in Paris. In general, their competition can be regarded as an extension of the fundamental differences that separated the research schools of Robert Koch and Louis Pasteur. However, to characterize the competition for a diphtheria-serum as "national rivalry" fails to account adequately for the mutual adoption of experimental practices by the Berlin and Parisian protagonists, whose contributions to the development of a therapeutic serum were intertwined in complex ways. Nor can it be characterized as "cooperation," given their fierce public disputes over scientific concepts and the fact that these disputes also shaped the peculiarities of the experimental procedures in Berlin and Paris. A close analysis reveals a complex picture of the dynamic interaction between the conceptual and experimental activities of Behring, Roux, and Metschnikoff- interaction that defined as well as bridged the "French" and "Prussian" experimental systems of diphtheria-serum research.

  16. Identification of Immunodominant Responses to the Plasmodium falciparum Antigens PfUIS3, PfLSA1 and PfLSAP2 in Multiple Strains of Mice.

    Directory of Open Access Journals (Sweden)

    Rhea J Longley

    Full Text Available Malaria, caused by the Plasmodium parasite, remains a serious global public health concern. A vaccine could have a substantial impact on eliminating this disease, alongside other preventative measures. We recently described the development of three novel, viral vectored vaccines expressing either of the antigens PfUIS3, PfLSA1 and PfLSAP2. Each vaccination regimen provided high levels of protection against chimeric parasite challenge in a mouse model, largely dependent on CD8+ T cells. In this study we aimed to further characterize the induced cellular immune response to these vaccines. We utilized both the IFNγ enzyme-linked immunosorbent spot assay and intracellular cytokine staining to achieve this aim. We identified immunodominant peptide responses for CD4+ and CD8+ T cells for each of the antigens in BALB/c, C57BL/6 and HLA-A2 transgenic mice, creating a useful tool for researchers for subsequent study of these antigens. We also compared these immunodominant peptides with those generated from epitope prediction software, and found that only a small proportion of the large number of epitopes predicted by the software were identifiable experimentally. Furthermore, we characterized the polyfunctionality of the induced CD8+ T cell responses. These findings contribute to our understanding of the immunological mechanisms underlying these protective vaccines, and provide a useful basis for the assessment of these and related vaccines as clinical constructs.

  17. The French experience

    CERN Document Server

    Bougard, Marie-Thérèse

    2003-01-01

    Developed for beginners, The French Experience 1 course book is designed to accompany the French Experience 1 CDs (9780563472582) but can also be used on its own to develop your reading and writing skills. You’ll gain valuable insights into French culture too.

  18. Motivational Distortion on 16 PF Primaries by Male Felons.

    Science.gov (United States)

    Wallbrown, Fred H.; And Others

    1989-01-01

    Investigated motivational distortion using the 16 Personality Factor Questionnaire (16 PF) for male (n=331) criminal offenders. Results indicated that ego-strength, free-floating anxiety, ability to bind anxiety, boldness, dominance, emotional sensitivity and suspiciousness contributed most to the motivational distortion scale predictions.…

  19. Trypanosoma cruzi: avirulence of the PF strain to Callithrix marmosets

    Directory of Open Access Journals (Sweden)

    Humberto Menezes

    1981-06-01

    Full Text Available Callithrix jacchus geoffroy marmosets (HumBol. 1812 were injected once subcutaneously with 10.000 parasites/g body weight and followed for a period of six months. The PF strain of Trypanosoma cruzi was used. Follow-up was done through blood cultures, xenodiagnosis, serological tests, and ECG. A small number of normaI animais served as control.

  20. Properties of Sago Particleboards Resinated with UF and PF Resin

    Directory of Open Access Journals (Sweden)

    Chen Chiang Tay

    2016-01-01

    Full Text Available The sago processing industry in Mukah, Sarawak, had generated huge amount of sago waste after the milling process and scientists have employed the waste into composite material. In this work, sago residues were mixed with the Phenol Formaldehyde (PF and Urea Formaldehyde (UF for particleboard fabrication. The fabrication and testing methods are based on JIS A 5908 Standard. A single layer particleboard using sago particles was fabricated at targeted density of 600 kg/m3. Particles with weight fractions of 90%, 85%, and 80% with two different matrices were used in the fabrication. The results demonstrated that the samples with different weight fraction and matrix have great influence on the mechanical properties such as MOR, MOE, Young’s Modulus, tensile strength, impact strength, screw test, and internal bonding. The sago UF/PF particleboard only displays single stage decomposition. All the panels underwent physical tests which are water absorption and thickness swelling. The combination of sago particles with UF/PF can be utilized for general indoor application purposes such as furniture manufacturing. Sago particleboard made by UF/PF provided the advantages like optimized performance, minimized weight and volume, cost effectiveness, chemical resistance, and resistance to biodegradation.

  1. Seismic analysis of ITER fourth PF (Poloidal Field Coil) feeder

    International Nuclear Information System (INIS)

    Liu, Sumei; Chen, Wei; Song, Yuntao; Ni, Xiaojun; Wang, Zhongwei; Chen, Yonghua; Gong, Chenyu

    2014-01-01

    The ITER feeder systems connect the ITER magnet systems located inside the main cryostat to the cryo-plant, power-supply and control system interfaces outside the cryostat. The main purpose of the feeders is to convey the cryogenic supply and electrical power to the coils as well as house the instrumentation wiring. The PF busbar which carries 52 kA current will suffer from high Lorentz force due to the background magnetic field inspired by the coils and the self-field between every pair of busbars. Except their mechanical strength and thermal insulation performance must be achieved, the dynamic mechanism on PF structure should be assessed. This paper presents the simulation and seismic analysis on ITER 4th PF feeder including the Coil Terminal Box and S-bend Box (CTB and SBB), the Cryostat Feed-through (CFT), the In-Cryostat-Feeder (ICF), especially for the ground supports and main outer-tube firstly. This analysis aims to study seismic resistance on system design under local seismograms with floor response spectrum, the structural response vibration mode and response duration results of displacement, membrane stress, and bending stress on structure under different directions actuating signals were obtained by using the single-seismic spectrum analysis and Dead Weight analysis respectively. Based on the simulative and analytical results, the system seismic resistance and the integrity of the support structure in the 4th PF feeder have been studied and the detail design confirmed

  2. Nature and climatology of Pfänderwind

    Directory of Open Access Journals (Sweden)

    Alexander Gohm

    2015-04-01

    Full Text Available The characteristics and climatology of Pfänderwind, a largely unknown downslope windstorm near the town of Bregenz (Austria at the entrance of the Rhine Valley, are investigated based on an eleven-year dataset of weather station observations and ERA-Interim reanalyses. The goal is to clarify the inconsistency in the definition of this phenomenon, to illuminate its dynamics, and to quantify its frequency of occurrence. It is shown that Pfänderwind has similarities to foehn but does occur for different synoptic-scale conditions. Moreover, two types of Pfänderwind have to be distinguished: Type 1, or classical Pfänderwind, is associated with easterly to northeasterly large-scale flow that crosses the Pfänder mountain range, descends in a foehn-like manner and causes moderate to strong winds in the town of Bregenz and its vicinity. The temperature anomaly induced at the surface by adiabatic warming is small as a result of weak low-level stability. Type-1 events occur on average 12 times per year, preferentially in spring, and most frequently between the afternoon and midnight. Type 2, or southeast Pfänderwind, is associated with westerly to southwesterly ambient winds near the main Alpine crest level. The Rhine valley is filled with cold air and in most cases south foehn is not present. However, the synoptic and meso-scale pressure gradient favours southerly ageostrophic flow in the Rhine Valley especially near the top of the cold-air pool. This flow passes the Gebhardsberg, the southwestern extension of the Pfänder mountain range, descends on its leeward side and causes strong foehn-like warming at the surface. However, southerly to southeasterly near-surface winds at Bregenz are rather weak. Type-2 events occur on average 40 times per year, most frequently between the evening and the early morning, and exhibit a weak seasonal dependence. More than half of all type-1 and type-2 events last only one or two hours.

  3. French grammar and usage

    CERN Document Server

    Hawkins, Roger

    2015-01-01

    Long trusted as the most comprehensive, up-to-date and user-friendly grammar available, French Grammar and Usage is a complete guide to French as it is written and spoken today. It includes clear descriptions of all the main grammatical phenomena of French, and their use, illustrated by numerous examples taken from contemporary French, and distinguishes the most common forms of usage, both formal and informal.Key features include:Comprehensive content, covering all the major structures of contemporary French User-friendly organisation offering easy-to-find sections with cross-referencing and i

  4. French For Dummies

    CERN Document Server

    Erotopoulos; Williams, Michelle M; Wenzel, Dominique

    2011-01-01

    The fast, informal way to learn to speak French French is known as perhaps the most beautiful of all languages. Listen to someone speak French-sure, you don't have a clue what they're saying, but aren't you enraptured by the sound of it? French is a beautiful language but quite difficult to learn. Whether you need to learn the language for a French class, or you travel overseas for business or leisure, this revised edition of French for Dummies can help. Written in an easy-to-follow format, it gives you just what you need for basic communication in FrenchExpanded coverage of necessary grammar,

  5. The dynamics of the fungal aerospores Alternaria sp. and Cladosporium sp. in Parisian atmospheric air, in France

    Science.gov (United States)

    Brezoczki, V. M.

    2016-08-01

    The bioallergens occurring naturally in the atmospheric air are microorganisms, pollen grains, plant seeds, leaf and stem scrap, or their protein molecules. The presence of various airborne fungal spores determines a high allergenic potential for public health. This effect is due to the high number of produced spores, which under favourable meteorological conditions (dry weather and wind) reach the surrounding air. This paper traces the dynamics of two types of fungi, Alternaria sp and Cladosporium sp, fungi which can be found outdoors, in the surrounding air, as well as indoors, inside houses (especially the conidia of Cladosporium sp). The effects of these fungal spores on human health are varies, ranging from seasonal allergies (hay fever, rhinitis, sinusitis etc.) to sever afflictions of the respiratory system, onset of asthma, disfunctionalities of the nervous systems, of the immune system, zymoses etc. The monitoring of the dynamics of the aerospores Alternaria sp and Cladosporium sp was carried out between 2010 and 2013, over a period of 42 weeks during one calendar year, from February to the end of September, in the surrounding air in the French capital, Paris. The regional and global climate and meteorological conditions are directly involved in the occurrence and development of fungi colonies, the transportation and dispersion of fungal spores in the atmospheric air, as well as in the creation of the environment required for the interaction of chemical and biological components in the air. Knowledge of the dynamics of the studied fungal aerospores, coupled with climate and meteorological changes, offers a series of information on the magnitude of the allergenic potential these airborne spores can determine. Legal regulations in this domain set the allergen risk threshold for the Alternaria sp aerospores at 3500 ÷ 7000 spores/m3 air/week, and for the Cladosporium sp aerospores at 56,000 spores/m3 air/week. Besides these regulations there exist a series of

  6. A nuclear magnetic resonance study of (TMTSF) 2PF 6

    Science.gov (United States)

    McBrierty, V. J.; Douglass, D. C.; Wudl, F.

    1982-09-01

    Inverse linewidths and spin-lattice relaxation times of fluorine and proton magnetic resonance spectra are used to examine molecular motion in the organic superconductor (TMTSF) 2PF 6. The results clearly show that rotation of the PF 6- anion is the principal agent for the observed relaxation of fluorine contrary to some suggestions in the current literature. This interpretation is based upon qualitative comparison with relaxation in plastic crystals, where molecular rotation is well characterized, and upon the quantitative agreement between the calculated and observed linewidth change near 90K and the maximum spin-lattice relaxation rate at 140K. There is also motional evidence, supported by X-ray structure measurements, that a phase transition occurs in the vicinity of 160K.

  7. PWR plant transient analyses using TRAC-PF1

    International Nuclear Information System (INIS)

    Ireland, J.R.; Boyack, B.E.

    1984-01-01

    This paper describes some of the pressurized water reactor (PWR) transient analyses performed at Los Alamos for the US Nuclear Regulatory Commission using the Transient Reactor Analysis Code (TRAC-PF1). Many of the transient analyses performed directly address current PWR safety issues. Included in this paper are examples of two safety issues addressed by TRAC-PF1. These examples are pressurized thermal shock (PTS) and feed-and-bleed cooling for Oconee-1. The calculations performed were plant specific in that details of both the primary and secondary sides were modeled in addition to models of the plant integrated control systems. The results of these analyses show that for these two transients, the reactor cores remained covered and cooled at all times posing no real threat to the reactor system nor to the public

  8. Introduction and immigration of TRAC-PF1 code

    International Nuclear Information System (INIS)

    Yan Yuhua; Gao Zuying; Gao Cheng; Li Jincai

    1997-01-01

    TRAC-PF1 code performs best-estimate predictions of postulated accidents for pressurized light water reactors. It is one of the few system analyse codes which use two fluid model to treat two phase problems in nuclear system. In order to use this advanced software in China and make it possible to be run in different compute systems, IBM version of TRAC-PF1 code, imported from USA National Energy Software Center, is immigrated to CDC NOS/VE system and SUN workstation. The differences in computer languages from IBM 370 to CDC NOS/VE and to SUN workstation are modified properly. All the benchmark problems are calculated, and the results show that the immigration is successful

  9. TRAC-PF1/MOD2 status and plans

    International Nuclear Information System (INIS)

    Spore, J.W.; Steinke, R.G.; Nelson, R.A.; Cappiello, M.W.; Jenks, R.

    1989-01-01

    The development of the TRAC-PF1/MOD1 code was completed in July 1988 with the release of Version 14.4. A TRAC-PF1/MOD2 code development plan addresses code deficiencies identified in the MOD1 code in order to provide an accurate and defensible tool that can be used to simulate large-break loss-of-coolant accidents (LOCAs), small-break LOCAs, and operational transients. The MOD2 code development plan is an international cooperative effort that includes contributions from Los Alamos National Laboratory, Idaho National Engineering Laboratory (INEL), Japanese Atomic Energy Research Institute (JAERI), Cray Research, Central Electricity Generating Board (CEGB), and United Kingdom Atomic Energy Authority (UKAEA)

  10. Medtner. Piano concertos. Geoffrey Tozer (pf) / Bryce Morrison

    Index Scriptorium Estoniae

    Morrison, Bryce

    1992-01-01

    Uuest heliplaadist "Medtner. Piano concertos. Geoffrey Tozer (pf) London Philarmonic Orchestra, Neeme Järvi. Chandos CHAN 9038/9 (two discs, oas 73 and 54 minutes). Also available as a two-disc set CD CHAN 9040. CHAN 9038: Piano concertos - N2 Op. 50; N 3 Op. 60 "Ballade" CHAN 9039 Piano concerto N 1 in C minor. Sonata-Ballade in Fsharp major Op. 27"

  11. Ion beams from high-current PF facilities

    Energy Technology Data Exchange (ETDEWEB)

    Sadowski, M [Soltan Inst. for Nuclear Studies, Otwock-Swierk (Poland)

    1997-12-31

    Pulsed beams of fast deuterons and impurity or admixture ions emitted from high-current PF-type facilities operated in different laboratories are dealt with. A short comparative analysis of time-integrated and time-resolved studies is presented. Particular attention is paid to the microstructure of such ion beams, and to the verification of some theoretical models. (author). 5 figs., 19 refs.

  12. TRAC-PF1/MOD1 computer code

    International Nuclear Information System (INIS)

    Liles, D.R.; Mahaffy, J.H.

    1983-01-01

    TRAC-PF1 was designed to improve the ability of TRAC-PD2 to handle small-break LOCAs and other transients. TRAC-PF1 has all of the major improvements of TRAC-PD2 but, in addition, uses a full two-fluid model with two-step numerics in the one-dimensional components. The two-fluid model, in conjunction with a stratified-flow regime, handles countercurrent flow better than the drift-flux model previously used. The two-step numerics allow large time steps to be taken for slow transients. TRAC-PF1/MOD1 was designed to provide full balance-of-plant modeling capabilities. This required addition of a general capability for modeling plant control systems. The steam generator model was replaced to allow a wider variety of feedwater connections and better modeling of steam tube ruptures. A special turbine component also has been added, but new components were not required for adequate modeling of condensors, heaters, and pumps in the secondary system

  13. TRAC-PF1/MOD1 assessment at Los Alamos

    International Nuclear Information System (INIS)

    Knight, T.D.

    1984-01-01

    The Los Alamos National Laboratory is developing the Transient Reactor Analysis Code (TRAC) to provide an advanced best-estimate predictive capability for the analysis of postulated accidents in pressurized water reactors (PWRs). Over the past several years, four distinct versions of the code have been released; each new version introduced improvements to the existing models and numerics and added new models to extend the applications of the code. The first goal of the code was to analyze large-break loss-of-coolant accidents (LOCAs), and the TRAC-P1A and TRAC-PD2 codes primarily addressed the large-break LOCA. (The TRAC-PD2/MOD1 code is essentially the same as the TRAC-PD2 code but it also includes a released set of error corrections.) The TRAC-PF1 code contained major changes to the models and trips and to the numerical methods. These modifications enhanced the computational speed of the code and improved the application to small-break LOCAs. The TRAC-PF1/MOD1 code, the latest released version, added improved steam-generator modeling, a turbine component, and a control system together with modified constitutive relations to model the balance of plant on the secondary side and to extend the applications to non-LOCA transients. The TRAC-PF1/MOD1 code also contains reasonably general reactor-kinetics modeling to facilitate the simulation of transients with delayed scram or without scram. 13 references, 24 figures

  14. A comprehensive French grammar

    CERN Document Server

    Price, Glanville

    2013-01-01

    Characterized by clear and accessible explanations, numerous examples and sample sentences, a new section on register and tone, and useful appendices covering topics including age and time, A Comprehensive French Grammar, Sixth Edition is an indispensable tool for advanced students of French language and literature.A revised edition of this established, bestselling French grammarIncludes a new section on register and medium and offers expanded treatment of French punctuationFeatures numerous examples and sample sentences, and useful appendices covering topics including age, time, and dimension

  15. French essentials for dummies

    CERN Document Server

    Lawless, Laura K

    2011-01-01

    Just the core concepts you need to write and speak French correctly If you have some knowledge of French and want to polish your skills, French Essentials For Dummies focuses on just the core concepts you need to communicate effectively. From conjugating verbs to understanding tenses, this easy-to-follow guide lets you skip the suffering and score high at exam time. French 101 - get the lowdown on the basics, from expressing dates and times to identifying parts of speech Gender matters - see how a noun's gender determines the articles, adjectives, and pronouns y

  16. The new French Development aid towards French-speaking Africa

    OpenAIRE

    Konate, Sindou Michel

    2013-01-01

    This project is focused on French president François Hollande new policy initiation around French Development assistance issue, particularly to French speakingAfrica South of the Sahara. President Hollande wishes to distance himself from the practices of his predecessors on French Public Development Assistance toward its former African colonies This project is focused on French president François Hollande new policy initiation around French Development assistance issue, particularly to Fre...

  17. French PWR Safety Philosophy

    International Nuclear Information System (INIS)

    Conte, M. M.

    1986-01-01

    The first 900 MWe units, built under the American Westinghouse licence and with reference to the U. S. regulation, were followed by 28 standardized units, C P1 and C P2 series. Increasing knowledge and lessons learned from starting and operating experience of French nuclear power plants, completed by the experience learned from the operation of foreign reactors, has contributed to the improvement of French PWR design and safety philosophy. As early as 1976, this experience was taken into account by French Safety organisms to discuss, with Electricite de France, the safety options for the planned 1300 MWe units, P4 and P4 series. In 1983, the new reactor scheduled, Ni4 series 1400 MWe, is a totally French design which satisfies the French regulations and other French standards and codes. Based on a deterministic approach, the French safety analysis was progressively completed by a probabilistic approach each of them having possibilities and limits. Increasing knowledge and lessons learned from operating experience have contributed to the French safety philosophy improvement. The methodology now applied to safety evaluation develops a new facet of the in depth defense concept by taking highly unlikely events into consideration, by developing the search of safety consistency of the design, and by completing the deterministic approach by the probabilistic one

  18. Routledge French technical dictionary

    CERN Document Server

    1994-01-01

    The French-English volume of this highly acclaimed set consists of some 100,000 keywords in both French and English, drawn from the whole range of modern applied science and technical terminology. Covers over 70 subject areas, from engineering and chemistry to packaging, transportation, data processing and much more.

  19. French nuclear organization

    International Nuclear Information System (INIS)

    Naudet, G.

    1993-01-01

    The French nuclear organization is characterized by two main features: the small number of firms involved and the role of the Government. In this text we give the French organization for nuclear industry and the role of Government and public authorities. 7 figs

  20. Geographic structuring of the Plasmodium falciparum sarco(endoplasmic reticulum Ca2+ ATPase (PfSERCA gene diversity.

    Directory of Open Access Journals (Sweden)

    Ronan Jambou

    Full Text Available Artemisinin, a thapsigargin-like sesquiterpene has been shown to inhibit the Plasmodium falciparum sarco/endoplasmic reticulum calcium-ATPase PfSERCA. To collect baseline pfserca sequence information before field deployment of Artemisinin-based Combination therapies that may select mutant parasites, we conducted a sequence analysis of 100 isolates from multiple sites in Africa, Asia and South America. Coding sequence diversity was large, with 29 mutated codons, including 32 SNPs (average of one SNP/115 bp, of which 19 were novel mutations. Most SNP detected in this study were clustered within a region in the cytosolic head of the protein. The PfSERCA functional domains were very well conserved, with non synonymous mutations located outside the functional domains, except for the S769N mutation associated in French Guiana with elevated IC(50 for artemether. The S769N mutation is located close to the hinge of the headpiece, which in other species modulates calcium affinity and in consequence efficacy of inhibitors, possibly linking calcium homeostasis to drug resistance. Genetic diversity was highest in Senegal, Brazil and French Guiana, and few mutations were identified in Asia. Population genetic analysis was conducted for a partial fragment of the gene encompassing nucleotide coordinates 87-2862 (unambiguous sequence available for 96 isolates. This supported a geographic clustering, with a separation between Old and New World samples and one dominant ancestral haplotype. Genetic drift alone cannot explain the observed polymorphism, suggesting that other evolutionary mechanisms are operating. One possible contributor could be the frequency of haemoglobinopathies that are associated with calcium dysregulation in the erythrocyte.

  1. Essential French grammar

    CERN Document Server

    Thacker, Mike

    2014-01-01

    Essential French Grammar is an innovative reference grammar and workbook for intermediate and advanced undergraduate students of French (CEFR levels B2 to C1). Its clear explanations of grammar are supported by contemporary examples and lively cartoon drawings.  Each chapter contains: * real-life language examples in French, with English translations * a 'key points' box and tables that summarise grammar concepts * a variety of exercises to reinforce learning * a contemporary primary source or literary extract to illustrate grammar in context. To aid your understanding, this book also contains a glossary of grammatical terms in French and English, useful verb tables and a key to the exercises. Together, these features all help you to grasp complex points of grammar and develop your French language skills.

  2. What French for Gabonese French Lexicography

    African Journals Online (AJOL)

    user

    administration, international relations, teaching, the media, trade, transport, tourism, .... The present study refutes such as reductive definition of what Gabonese .... language than French limits itself to public speeches and support to linguistics ...... sité Omar Bongo du Gabon: Série Lettres, Droit, Sciences et Médecine: 55-63.

  3. Analysis of the PLC object model in the PF linac

    International Nuclear Information System (INIS)

    Abe, Isamu; Shirakawa, Akihiro; Nakahara, Kazuo; Tanaka, Masahiko

    1995-01-01

    Device controllers (front end) for the KEK PF Linac, which has been operated for more than ten years, had to be renewed, because there is no longer support from hardware manufacturer. To reduce maintenance costs, device controllers are planed to be replaced by PLC (Programmable Logic Controller). Investigations launched in the late 1994s for the PLC have carried out in order to make sure of the I/O stability and network possibilities. In this paper, the software for the PLC is discussed based on the OOP concept. (author)

  4. Current distribution between petals in PF-FSJS sample

    International Nuclear Information System (INIS)

    Zani, L.

    2003-01-01

    6 Rogowski coils have been installed on each leg of each of the 12 petals in the PF-FSJS sample (poloidal field - full size joint sample) in order to diagnostic current. It appears that Rogowski signal seem reliable for current distribution analysis (Ampere's law is checked and reproducibility is assured) but there is some limitations for qualitative diagnostics. In the series of transparencies results are detailed for the PU1 position, for both leg and right legs and for various unique-angle shift (Δθ) configurations but only results for 0 < Δθ < -5 are consistent

  5. French in Culinary World

    Directory of Open Access Journals (Sweden)

    Rila Hilma

    2011-10-01

    Full Text Available More than million foods have been made by people from all over the world in the latest years. People now try to create new cooks and make some creativity on it. Then, cooking which the field is culinary has become an art because it needs an artistic value to decorate the food, a good taste and proper technique in processing delicious food in order to make it a masterpiece. French culinary is as famous as the Eiffel tower in the heart of the country, Paris. Most of fine dining international restaurants apply the French menu and cooking. This article presents an overview about the French element in culinary world; starts from its history, kitchen organization, French menu spelling, and French cooking vocabulary. The discussion proceeds library research to compile the data. Later, the art of culinary is interesting to be learned because it contains the classical history of world civilization, in this case French civilization. The issue of cooking trend “nouvelle cuisine” was a masterpiece of one of the greatest chef in his time, Escoffier. French culinary is widely well-known in all over the world because of innovation, creativity, and proud. Those are spirits that we must learn.   

  6. What French for Gabonese French lexicography? | Assam | Lexikos

    African Journals Online (AJOL)

    This paper is a response to Mavoungou (2013a) who has pleaded for the production of a dictionary of Gabonese French as variant B of the French language. The paper intends to com-prehend the concept of "Gabonese French". It gives an outline of the situation of French within the language diversity of Gabon as a ...

  7. Use of French, Attitudes and Motivations of French Immersion Students.

    Science.gov (United States)

    Van der Keilen, Marguerite

    1995-01-01

    Compares the degree to which pupils in the French immersion and regular English school programs speak French and initiate contact with French people. Attitudes and motivations were significantly more positive, and social tolerance and self-rated competency in French were much higher in the immersion than in English program subjects. (29…

  8. French PWR safety philosophy

    International Nuclear Information System (INIS)

    Conte, M.

    1986-05-01

    Increasing knowledge and lessons learned from starting and operating experience of French nuclear power plants, completed by the experience learned from the operation of foreign reactors, has contributed to the improvement of French PWR design and safety philosophy. Based on a deterministic approach, the French safety analysis was progressively completed by a probabilistic approach, each of them having possibilities and limits. As a consequence of the global risk objective set in 1977 for nuclear reactors, safety analysis was extended to the evaluation of events more complex than the conventional ones, and later to the evaluation of the feasibility of the offsite emergency plans in case of severe accidents

  9. Flirting with French

    CERN Document Server

    Alexander, William

    2015-01-01

    William Alexander is not just a Francophile, he wants to be French. It's not enough to explore the country, to enjoy the food and revel in the ambience, he wants to feel French from the inside. Among the things that stand in his way is the fact that he can't actually speak the language. Setting out to conquer the language he loves (but which, amusingly, does not seem to love him back), Alexander devotes himself to learning French, going beyond grammar lessons and memory techniques to delve into the history of the language, the science of linguistics, and the art of translation. Along

  10. The French and energy

    International Nuclear Information System (INIS)

    Rouquette, Celine; Moreau, Sylvain; Bottin, Anne; Reperant, Patricia

    2012-08-01

    In 2012, as in 2011, the French are favourable to renewable energy. If they could, around 60% of them would opt for solar, fuelwood or heat pumps for heating. Wind power is also viewed favourably. Aware of environmental issues, the French are prepared to change their habits in the face of climate change, and two-thirds are even prepared to make sacrifices. One-third declares having already taken action or intending to do so to reduce their energy consumption. The cost of energy remains a central issue: faced with higher prices, half of French people would reduce their consumption. However, information on the subject of energy needs to be improved. (authors)

  11. PF-WFS Shell Inspection Update December 2016

    Energy Technology Data Exchange (ETDEWEB)

    Vigil, Anthony Eugene [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Ledoux, Reina Rebecca [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Gonzales, Antonio R. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Montano, Joshua Daniel [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Savage, Lowell Curtis [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Randles, Wayne Alfred [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-01-26

    Since the last project update in FY16:Q2, PF-WFS personnel have advanced in understanding of shell inspection on Coordinate Measuring Machines {CMM} and refined the PF-WFS process to the point it was decided to convert shell inspection from the Sheffield #1 gage to Lietz CM Ms. As a part of introspection on the quality of this process many sets of data have been reviewed and analyzed. This analysis included Sheffield to CMM comparisons, CMM inspection repeatability, fixturing differences, quality check development, probing approach changes. This update report will touch on these improvements that have built the confidence in this process to mainstream it inspecting shells. In addition to the CMM programming advancements, the continuation in refinement of input and outputs for the CMM program has created an archiving scheme, input spline files, an output metafile, and inspection report package. This project will continue to mature. Part designs may require program modifications to accommodate "new to this process" part designs. Technology limitations tied to security and performance are requiring possible changes to computer configurations to support an automated process.

  12. French plutonium management program

    International Nuclear Information System (INIS)

    Greneche, D.

    2002-01-01

    The French plutonium management program is summarized in this paper. The program considers nuclear generation as a major component of national electric power supply and includes the reprocessing of the spent fuel. (author)

  13. French Dictionaries. Series: Specialised Bibliographies.

    Science.gov (United States)

    Klaar, R. M.

    This is a list of French monolingual, French-English and English-French dictionaries available in December 1975. Dictionaries of etymology, phonetics, place names, proper names, and slang are included, as well as dictionaries for children and dictionaries of Belgian, Canadian, and Swiss French. Most other specialized dictionaries, encyclopedias,…

  14. The French coal board and French society

    International Nuclear Information System (INIS)

    Ladoucette, Ph. de

    2004-01-01

    On 19 April 1946 the French national assembly passed a law for nationalizing the mineral fuel industry by a vote of 516 against only 31. 'Charbonnages de France' (CDF), the French coal board, was created and prospects were promising. During the reconstruction period (1945 - 1960), coal industry was a pillar of the French economy, the production of coal had been steadily growing to reach its top in 1958 with 59 Mt. The sixties showed the beginning of the decline of coal to the benefit of oil, natural gas and later nuclear energy. As early as 1967 CDF had a policy of promoting new industries in regions of mines in order to break down the mono-industry scheme and to favor staff conversion massively. In 1947 the number of people on the payroll of CDF was 360.000, this number was decreasing steadily to reach 23.000 in 1990. In 2004 the last deep mine to work in France was closed down. This article tells the story of coal mining in France by describing its ups and downs and by assessing its social impact

  15. 500 French verbs for dummies

    CERN Document Server

    Erotopoulos

    2013-01-01

    Vexed by French verbs? Fear no more! In 500 French Verbs For Dummies, beginning French language learners can find a quick reference for verbs in the basic present tenses. More advanced French speakers can utilize this book to learn more complex verb tenses and conjugations as well as advanced verbs with irregular endings. One page for each of the 500 most commonly used verbs in the French language -alphabetically arranged and numbered for easy referenceSpecial designation of the 50 most essential French verbsA summary of basic French grammar that incl

  16. English and French courses

    CERN Multimedia

    2014-01-01

    If one of your New Year’s resolutions is to learn a language, there is no excuse anymore!   You can attend one of our English or French courses and you can practise the language with a tandem partner! General and Professional French Courses The next session will take place from 27 January to 4 April 2014. These courses are open to all persons working on the CERN site, and to their spouses. Oral Expression This course is aimed at students with a good knowledge of French who want to enhance their speaking skills. Speaking activities will include discussions, meeting simulations, role-plays etc. The next session will take place from 27 January to 4 April 2014. Writing professional documents in French These courses are designed for non-French speakers with a very good standard of spoken French. The next session will take place from 27 January to 4 April 2014. Cours d’anglais général et professionnel La prochaine session se déroulera du 3 mars a...

  17. Cross-cultural Adaptation and Validation of the Victorian Institute of Sport Assessment-Patella Questionnaire for French-Speaking Patients With Patellar Tendinopathy.

    Science.gov (United States)

    Kaux, Jean-François; Delvaux, François; Oppong-Kyei, Julian; Beaudart, Charlotte; Buckinx, Fanny; Croisier, Jean-Louis; Forthomme, Bénédicte; Crielaard, Jean-Michel; Bruyère, Olivier

    2016-05-01

    Study Design Clinical measurement study. Background The Victorian Institute of Sport Assessment-Patella (VISA-P), originally developed in English, assesses the severity of patellar tendinopathy symptoms. To date, no French version of the questionnaire exists. Objectives The aim of our study was to translate the VISA-P into French and verify its psychometric properties. Methods The translation and cultural adaptation were performed according to international recommendations in 6 steps: initial translation, translation merging, back translation to the original language, use of an expert committee to reach a prefinal version, test of the prefinal version, and expert committee appraisal of a final version. Afterward, the psychometric properties of the final French version (VISA-PF) were assessed in 92 subjects, divided into 3 groups: pathological subjects (n = 28), asymptomatic subjects (n = 22), and sports-risk subjects (n = 42). Results All members of the expert committee agreed with the final version. On a scale ranging from 0 to 100, with 100 representing an asymptomatic subject, the average ± SD scores on the VISA-PF were 53 ± 17 for the pathological group, 99 ± 2 for the healthy group, and 86 ± 14 for the sports-risk group. The test-retest reliability of the VISA-PF was excellent, with good internal consistency. Correlations between the VISA-PF and divergent validity of the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) were low, and the correlation coefficient values measured between the VISA-PF scores and converged items of the SF-36 were higher. Conclusion The VISA-PF is understandable, valid, and suitable for French-speaking patients with patellar tendinopathy. J Orthop Sports Phys Ther 2016;46(5):384-390. Epub 21 Mar 2016. doi:10.2519/jospt.2016.5937.

  18. Private Finance 2 (PF2): Re-inventing the Wheel?

    Science.gov (United States)

    Zawawi, N. A. W. A.; Abdul-Aziz, A. R.; Khamidi, M. F.; Othman, I.; Idrus, A.; Umar, A. A.

    2013-06-01

    The Procurement policy of any government is the most influential factor in determining the efficiency of infrastructure and service provision like roads, water supply and energy. The UK's HM Treasury released its new guidelines on private involvement in infrastructures provision and services towards reforming the popular Private Finance Initiatives (PFI) policy. This new approach, it now refers to as the Private Finance 2 (PF2) is meant to correct the imperfections which have bedeviled the older version-PFI. However, the 'new guidelines' contained nothing really new in the area of private financing and operation of public infrastructures, at best it is akin to 're-inventing the wheel' rather than being 'new'. While dwelling extensively on issues relating to cheaper financing sources, risks transfer, counterpart funding by government and improving public sector procurement skills, this paper argues that some countries in the developing world have long recognised these issues and taken practical steps to correct them.

  19. Private Finance 2 (PF2): Re-inventing the Wheel?

    International Nuclear Information System (INIS)

    Zawawi, N A W A; Khamidi, M F; Othman, I; Umar, A A; Abdul-Aziz, A R; Idrus, A

    2013-01-01

    The Procurement policy of any government is the most influential factor in determining the efficiency of infrastructure and service provision like roads, water supply and energy. The UK's HM Treasury released its new guidelines on private involvement in infrastructures provision and services towards reforming the popular Private Finance Initiatives (PFI) policy. This new approach, it now refers to as the Private Finance 2 (PF2) is meant to correct the imperfections which have bedeviled the older version-PFI. However, the 'new guidelines' contained nothing really new in the area of private financing and operation of public infrastructures, at best it is akin to 're-inventing the wheel' rather than being 'new'. While dwelling extensively on issues relating to cheaper financing sources, risks transfer, counterpart funding by government and improving public sector procurement skills, this paper argues that some countries in the developing world have long recognised these issues and taken practical steps to correct them.

  20. The French energy policy

    International Nuclear Information System (INIS)

    Maillard, D.; Baulinet, Ch.; Lajoinie, A.

    2001-01-01

    France has to face strong energy challenges: a heavy energy bill, increasing supplies risk, no decreasing CO 2 emissions, deregulation of energy markets, nuclear controversy etc.. In consequence, the French government has defined a voluntaristic energy policy with a better balance between the development of renewable energies and the mastery of energy and without renouncing the advantages of nuclear energy. In parallel, the electric power and natural gas industries have to cope with the deregulation of energy markets and the resulting competition. This issue of 'Energies et Matieres Premieres' newsletter comprises 3 articles. The first one gives a general presentation of the French energy policy ('mobilizing our margins of manoeuvre without renouncing our stakes'): challenges of the energy policy (greenhouse effect, security of supplies, long-term worldwide energy context, European integration, nuclear contestation), stakes for France (evolution of production structure, advantages of the French energy status), renewable energies and energy saving, long-term view of the nuclear industry, managing together the dynamism of competition and the advantages of public utilities. The second article entitled 'energy for everybody: a challenge for the 21. century' is a reprint of the introduction of the information report registered on January 31, 2001 by the commission of production and exchanges of the French national assembly. The third article is a reprint of the summary of conclusions and recommendations of the IEA about the French energy policy. (J.S.)

  1. Language Training - French Training

    CERN Multimedia

    HR Department

    2008-01-01

    General and Professional French Courses The next session will take place from 26 January to 3rd April 2009. These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Nathalie Dumeaux : Tel. 78144. Writing Professional Documents in French The next session will take place from 26 January to 3rd April 2009. This course is designed for people with a good level of spoken French. Duration: 30 hours Price: 660 CHF For further information and registration, please consult our Web pages: http://cern.ch/Training or contact Mrs. Nathalie Dumeaux : Tel. 78144. Nathalie Dumeaux Tel. 78144 mailto:nathalie.dumeaux@cern.ch

  2. Language Training - French Training

    CERN Multimedia

    HR Department

    2009-01-01

    General and Professional French Courses The next session will take place from 26 January to 3rd April 2009. These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Nathalie Dumeaux : Tel. 78144. Writing Professional Documents in French The next session will take place from 26 January to 3rd April 2009. This course is designed for people with a good level of spoken French. Duration: 30 hours Price: 660 CHF For further information and registration, please consult our Web pages: http://cern.ch/Training or contact Mrs. Nathalie Dumeaux : Tel. 78144. Nathalie Dumeaux Tel. 78144 mailto:nathalie.dumeaux@cern.ch

  3. French nuclear experience

    International Nuclear Information System (INIS)

    Reynolds, M.; Barre, B.

    1984-01-01

    The French nuclear attache at the French Embassy in Washington discusses his country's energy program and his role at the embassy as a representative of the French nuclear industry. He reviews the nuclear program's growth since it began in 1945, and the impetus of the OPEC oil embargo to accelerate the program since 1973. The success of France's nuclear program is due to a convergence of reasons that include incentive, the existence of a single utility that could design and manage a project of this magnitude, and the decision to focus on the pressurized water reactor (PWR) built by a single supplier and offering the benefits of standardization. Controlling the fuel cycle is the basic philosophy of both the PWR and the breeder program. Barre recommends policies of pre-approved sites, standardization, and licensing reform for the US

  4. French Antilles and Guiana.

    Science.gov (United States)

    1983-11-01

    This discussion of French Antilles and Guiana cover the following: the people, geography, history, government, political conditions, economy, and relations with the US. In 1983 the population totaled 303,000 with an annual growth rate of 0.09%. The infant mortality rate (1981) was 12.6/1000 and life expectancy 68 years. About 98% of the people of Martinique are of Afro European or Afro European Indian descent. The remainder are the old planter families and a sizable number of metropolitan French. Most of the work force are employed in agriculture or food processing and associated industries. Most permanent residents of Guadeloupe are of mixed Afro European descent. A few thousand Metropolitan French reside there. Most French Guianese live along the coast, about 1/2 of them in the capital. Martinique is the northernmost of the Windward Islands, which are part of the Lesser Antilles chain in the Caribbean Sea southeast of Puerto Rico. Guadeloupe comprises 2 of the Leeward Islands, which are also part of the Lesser Antilles chain. French Guiana is located on the northern coast of South America, a few degrees north of the Equator. Indians were the 1st known indigenous inhabitants of French Guiana and the French Antilles. Columbus sighted Guadeloupe in 1493, Martinique in 1493 or 1502, and the Guiana coast probably during his 3rd voyage in 1498. French Guiana, Guadeloupe, and Martinique, as overseas departments of France since 1946, are integral parts of the French Republic. Their relationship to Metropolitan France is somewhat similar to that of Alaska and Hawaii to the counterminous US. Each department has a general council composed of 1 representative elected by each canton. Guadeloupe and Martinique each elect 2 senators to the French Senate and 3 deputies to the National Assembly. French Guiana elects 1 senator and 1 deputy. In each of the 3 departments exist individuals and small political parties that advocate immediate independence, but their adherents form only

  5. The French energy programme

    International Nuclear Information System (INIS)

    Bohnen, U.

    1980-01-01

    The challenge of the oil crisis made French energy policy react chiefly by means of a programme for the rapid expansion of nuclear energy which has become unparalleled because of its systematic realization. The following article gives a survey of this programme and its political preconditions. The French energy programme deserves special attention as the utilization of nuclear energy in France including all related activities has reached a more advanced stage than in most other countries. The effects and requirements connected with such an extensive programme which can therefore be investigated with the help of the French example migth be of importance also for other countries in a similar way. (orig./UA) [de

  6. Genomics-guided discovery of secondary metabolites and their regulation in Pseudomonas protegens Pf-5

    Science.gov (United States)

    Pseudomonas protegens strain Pf-5 is a well-characterized rhizosphere bacterium known for its production of a diverse spectrum of secondary metabolites and its capacity to suppress plant diseases caused by soilborne fungal, bacterial and oomycete pathogens. Metabolites produced by Pf-5 include 2,4-...

  7. Paracheck-PF ® test Versus Microscopy in the Diagnosis of ...

    African Journals Online (AJOL)

    Background: Malaria is a major cause of morbidity and mortality in Ethiopia. Rapid diagnostic tests such as Paracheck Pf are the major tools for falciparum malaria diagnosis as an alternative to microscopy in peripheral health facilities. The objective of this study was to evaluate the sensitivity and specificity of Paracheck Pf ...

  8. The rare codon AGA is involved in regulation of pyoluteorin biosynthesis in Pseudomonas protegens Pf-5

    Science.gov (United States)

    The soil bacterium Pseudomonas protegens Pf-5 can colonize root and seed surfaces of many plants, protecting them from infection by plant pathogenic fungi and oomycetes. This capacity to suppress disease is attributed in part to Pf-5’s production of a large spectrum of antibiotics, which is controll...

  9. Ferric-Pyoverdine Recognition by Fpv Outer Membrane Proteins of Pseudomonas protegens Pf-5

    Science.gov (United States)

    Hartney, Sierra L.; Mazurier, Sylvie; Girard, Maëva K.; Mehnaz, Samina; Davis, Edward W.; Gross, Harald; Lemanceau, Philippe

    2013-01-01

    The soil bacterium Pseudomonas protegens Pf-5 (previously called P. fluorescens Pf-5) produces two siderophores, enantio-pyochelin and a compound in the large and diverse pyoverdine family. Using high-resolution mass spectroscopy, we determined the structure of the pyoverdine produced by Pf-5. In addition to producing its own siderophores, Pf-5 also utilizes ferric complexes of some pyoverdines produced by other strains of Pseudomonas spp. as sources of iron. Previously, phylogenetic analysis of the 45 TonB-dependent outer membrane proteins in Pf-5 indicated that six are in a well-supported clade with ferric-pyoverdine receptors (Fpvs) from other Pseudomonas spp. We used a combination of phylogenetics, bioinformatics, mutagenesis, pyoverdine structural determinations, and cross-feeding bioassays to assign specific ferric-pyoverdine substrates to each of the six Fpvs of Pf-5. We identified at least one ferric-pyoverdine that was taken up by each of the six Fpvs of Pf-5. Functional redundancy of the Pf-5 Fpvs was also apparent, with some ferric-pyoverdines taken up by all mutants with a single Fpv deletion but not by a mutant having deletions in two of the Fpv-encoding genes. Finally, we demonstrated that phylogenetically related Fpvs take up ferric complexes of structurally related pyoverdines, thereby establishing structure-function relationships that can be employed in the future to predict the pyoverdine substrates of Fpvs in other Pseudomonas spp. PMID:23222724

  10. ESR study of weakly irradiated organic conductors: TMTSF-DMTCNQ and (TMTSF)2PF6

    International Nuclear Information System (INIS)

    Forro, L.; Beuneu, F.

    1982-01-01

    ESR experiments are presented on irradiated TMTSF-DMTCNQ and (TMTSF) 2 PF 6 . They suggest that a weak disorder extends the metallic phases to low temperatures. Surprisingly, disorder has no effect on the ESR linewidth of (TMTSF) 2 PF 6 between 20 and 30 K, where the d.c. conductivity changes a lot with disorder. (author)

  11. French grammar in context

    CERN Document Server

    Jubb, Margaret

    2013-01-01

    Instructors' edition without answer keysDiscount of 20% offered when 10 ebooks are sold- e.g. they will be sold for 263.60/ £151.90 instead of 329.50/£189.90French Grammar in Context presents a unique and exciting approach to learning grammar. Authentic texts from a rich variety of sources, literary and journalistic, are used as the starting point for the illustration and explanation of key areas of French grammar. Each point is consolidated with a wide range of written and spoken exercises. Grammar is presented not as an end in itself, but as a

  12. School of Economic French

    Directory of Open Access Journals (Sweden)

    I. S. Franceva

    2014-01-01

    Full Text Available Economic French at MGIMO-University is based on the teaching methods developed by talented Methodist practitioner assistant professor L.L. Potushanskoy. She and her colleagues G.M. Kotova, N. Kolesnikova, I.A. Yudina created well-known in our country methodical complex of three textbooks. This complex is built on clear guidelines to facilitate the natural development of language skills "from simple to complex" and represents the effective approach to language learning: Currently, the department is constantly expanding its boundaries of school teaching economic and business of the French language in accordance with the emerging new special courses on the economics faculties.

  13. Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543

    Energy Technology Data Exchange (ETDEWEB)

    Ju, TongFa [Department of Anal-colorectal Surgery, HangZhou First People' s Hospital, HangZhou (China); Gao, DaQuan [Hematological Department, HangZhou First People' s Hospital, HangZhou (China); Fang, Zheng-yu, E-mail: fangzhengyu158@sina.com [Department of Anal-colorectal Surgery, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou (China)

    2016-02-12

    In this study, we showed that PF-543, a novel sphingosine kinase 1 (SphK1) inhibitor, exerted potent anti-proliferative and cytotoxic effects against a panel of established (HCT-116, HT-29 and DLD-1) and primary human colorectal cancer (CRC) cells. Its sensitivity was negatively associated with SphK1 expression level in the CRC cells. Surprisingly, PF-543 mainly induced programmed necrosis, but not apoptosis, in the CRC cells. CRC cell necrotic death was detected by lactate dehydrogenase (LDH) release, mitochondrial membrane potential (MMP) collapse and mitochondrial P53-cyclophilin-D (Cyp-D) complexation. Correspondingly, the necrosis inhibitor necrostatin-1 largely attenuated PF-543-induced cytotoxicity against CRC cells. Meanwhile, the Cyp-D inhibitors (sanglifehrin A and cyclosporin A), or shRNA-mediated knockdown of Cyp-D, remarkably alleviated PF-543-induced CRC cell necrotic death. Reversely, over-expression of wild-type Cyp-D in HCT-116 cells significantly increased PF-543's sensitivity. In vivo, PF-543 intravenous injection significantly suppressed HCT-116 xenograft growth in severe combined immunodeficient (SCID) mice, whiling remarkably improving the mice survival. The in vivo activity by PF-543 was largely attenuated when combined with the Cyp-D inhibitor cyclosporin A. Collectively, our results demonstrate that PF-543 exerts potent anti-CRC activity in vitro and in vivo. Mitochondrial programmed necrosis pathway is likely the key mechanism responsible for PF-543's actions in CRC cells. - Highlights: • PF-543 is anti-proliferative and cytotoxic to established and primary CRC cells. • PF-543 induces programmed necrosis, but not apoptosis, in CRC cells. • Modulation of mitochondrial protein cyclophilin-D alters PF-543's sensitivity. • PF-543 inhibits HCT-116 xenograft growth in SCID mice, improving mice survival. • Co-administration of cyclophilin-D inhibitor CsA inhibits PF-543's activity in vivo.

  14. Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543

    International Nuclear Information System (INIS)

    Ju, TongFa; Gao, DaQuan; Fang, Zheng-yu

    2016-01-01

    In this study, we showed that PF-543, a novel sphingosine kinase 1 (SphK1) inhibitor, exerted potent anti-proliferative and cytotoxic effects against a panel of established (HCT-116, HT-29 and DLD-1) and primary human colorectal cancer (CRC) cells. Its sensitivity was negatively associated with SphK1 expression level in the CRC cells. Surprisingly, PF-543 mainly induced programmed necrosis, but not apoptosis, in the CRC cells. CRC cell necrotic death was detected by lactate dehydrogenase (LDH) release, mitochondrial membrane potential (MMP) collapse and mitochondrial P53-cyclophilin-D (Cyp-D) complexation. Correspondingly, the necrosis inhibitor necrostatin-1 largely attenuated PF-543-induced cytotoxicity against CRC cells. Meanwhile, the Cyp-D inhibitors (sanglifehrin A and cyclosporin A), or shRNA-mediated knockdown of Cyp-D, remarkably alleviated PF-543-induced CRC cell necrotic death. Reversely, over-expression of wild-type Cyp-D in HCT-116 cells significantly increased PF-543's sensitivity. In vivo, PF-543 intravenous injection significantly suppressed HCT-116 xenograft growth in severe combined immunodeficient (SCID) mice, whiling remarkably improving the mice survival. The in vivo activity by PF-543 was largely attenuated when combined with the Cyp-D inhibitor cyclosporin A. Collectively, our results demonstrate that PF-543 exerts potent anti-CRC activity in vitro and in vivo. Mitochondrial programmed necrosis pathway is likely the key mechanism responsible for PF-543's actions in CRC cells. - Highlights: • PF-543 is anti-proliferative and cytotoxic to established and primary CRC cells. • PF-543 induces programmed necrosis, but not apoptosis, in CRC cells. • Modulation of mitochondrial protein cyclophilin-D alters PF-543's sensitivity. • PF-543 inhibits HCT-116 xenograft growth in SCID mice, improving mice survival. • Co-administration of cyclophilin-D inhibitor CsA inhibits PF-543's activity in vivo.

  15. [Is the learning process of "evidence-based medicine" influenced by determined factors? Results from a national survey of 1870 French students in their sixth year].

    Science.gov (United States)

    Rouprêt, Morgan; Karila, Laurent; Kerneis, Solen; Lefevre, Jérémie H

    2010-06-01

    To investigate the baseline level of knowledge of evidence based medicine (EBM) concepts in a sample of French medical students in their sixth year of training. An "electronic-questionnaire" was proposed to 3125 sixth-year students from all 39 French medical schools in 2009. Overall, 1870 students (58.2% response rate) completed the questionnaire (women=1168; 63%). The concept of EBM was known by 1716 students (92%). Most students (n=1382; 74%) read at least one French medical article per year, but 1051 students (56%) never read international articles. Just over half of students (1030; 55%) knew of web-based medical information databases. Treatment guidelines were considered to be important by most students (97%). Only 24.3% and 29% of students said that they write or speak English. In multivariate analysis, studying in a Parisian University and/or knowledge of what a journal's "impact factor" is were both associated with a ranking in the top 20% of the National Ranking Exam practice session. Only the most successful students showed interest in obtaining more knowledge of EBM. The lack of education about EBM in this sample suggests a lack of efficacy in the current heterogeneous EBM teaching programs. Copyright 2010 Elsevier Masson SAS. All rights reserved.

  16. Comparing Written Competency in Core French and French Immersion Graduates

    Science.gov (United States)

    Lappin-Fortin, Kerry

    2014-01-01

    Few studies have compared the written competency of French immersion students and their core French peers, and research on these learners at a postsecondary level is even scarcer. My corpus consists of writing samples from 255 students from both backgrounds beginning a university course in French language. The writing proficiency of core French…

  17. The French nuclear law

    International Nuclear Information System (INIS)

    Ito, Hiroshi

    2013-01-01

    The nuclear law had been out of the environmental law. The act on the transparency and the security of the nuclear matter was enacted in 2006 and set in the code of the environment in 2012. It means that the nuclear law is part of the environmental law and that it is advanced. I will report the French nuclear law. (author)

  18. The French Collection

    NARCIS (Netherlands)

    Vergeest, Aukje

    2000-01-01

    'What's happening right now in Paris?' This must have been the question that preoccupied many a 19th-century art dealer and artist. For the modern artist who wanted to make it in that period, Paris was no doubt the place to be. And it's from here that considerable amounts of French art managed to

  19. Complete French Teach Yourself

    CERN Document Server

    Graham, Gaelle

    2010-01-01

    The best-selling complete course for a fun and effective way to learn French. This ISBN is for the paperback book. The corresponding audio support (ISBN: 9781444100068) is also available. The book and audio support can also be purchased as a pack (ISBN: 9781444100051).

  20. French Theory's American Adventures

    Science.gov (United States)

    Cusset, Francois

    2008-01-01

    In this article, the author discusses how it is simply too late to be still speaking about French theory and its role in the intellectual life of the United States today. It seems to many observers that the gap between real-life politics and theory's guerrillas is much too wide already, after 30 years of academic fever, for the two worlds to even…

  1. I Can Speak French.

    Science.gov (United States)

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    The guide presents content and techniques for teaching conversational French in the elementary grades. It contains an introductory section and 20 units for classroom instruction. The introduction includes notes on the overall objectives of the course, general guidelines on classroom procedure, and specific techniques for use of the materials…

  2. French Wines on the Decline?:

    DEFF Research Database (Denmark)

    Steiner, Bodo

    2004-01-01

    French wines, differentiated by geographic origin, served for many decades as a basis for the French success in the British wine market. However in the early 1990s, market share began to decline. This article explores the values that market participants placed on labelling information on French...

  3. Design report on PF injector linac upgrade for KEKB

    Energy Technology Data Exchange (ETDEWEB)

    Sato, Isamu; Anami, Shozo; Enomoto, Atsushi; Fukuda, Shigeki; Kobayashi, Hitoshi; Nakahara, Kazuo [eds.

    1966-03-01

    The purpose of the B Factory project is to verify the physical problem `Is there difference in the physical laws of particle world and anti-particle world?` The outline of the KEK B Factory project (KEKB) is explained. The condition of injection corresponding to the KEKB, the increase of the energy of the PF injector and the augmentation of positron beam intensity for the KEKB, the guideline for, the most important problems of and the schedule of energy augmentation are described. Buildings and utilities, various problems related to large current electron beam acceleration, the generation of positrons, the examination of acceleration method, beam transport system, acceleration unit, vacuum system, high frequency source, the high frequency phase control between beam and acceleration high frequency wave, electron beam injection system, trigger system, beam monitors, the precision alignment of acceleration tube, electromagnets and beam monitors, the extension of control system, rise and adjustment, and radiation safety and the application related to radiation are described. Efforts are exerted for the development of klystron, the capability of high frequency power compression system, and the withstanding to pressure of acceleration tube. (K.I.)

  4. PF120916 Piecki fireball and Reszel meteorite fall

    Science.gov (United States)

    Olech, A.; Żołądek, P.; Tymiński, Z.; Stolarz, M.; Wiśniewski, M.; Bęben, M.; Lewandowski, T.; Polak, K.; Raj, A.; Zaręba, P.

    2017-06-01

    On September 12, 2016, at 21:44:07 UT, a -9.2±0.5 mag fireball appeared over northeastern Poland. The precise orbit and atmospheric trajectory of the event are presented, based on the data collected by six video stations of the Polish Fireball Network (PFN). The PF120916 Piecki fireball entered the Earth's atmosphere with the velocity of 16.7±0.3 km/s and started to shine at a height of 81.9 ± 0.3 km. Clear deceleration started after first three seconds of the flight, and the terminal velocity of the meteor was only 5.0±0.3 km/s at a height of 26.0 ± 0.2 km. Such a low value of the terminal velocity indicates that fragments with the total mass of around 10-15 kg could survive the atmospheric passage and cause fall of the meteorites. The predicted area of possible meteorite impact is computed and it is located south of Reszel city at the Warmian-Masurian region. The impact area was extensively searched by experienced groups of meteorite hunters, but without any success.

  5. TRAC-PF1/MOD1 computer code

    International Nuclear Information System (INIS)

    Liles, D.R.; Mahaffy, J.H.

    1984-01-01

    The TRAC-P1 program was designed primarily for the analysis of large-break loss-of-coolant accidents (LOCAs) in pressurized water reactors (PWRs). Because of its versatility, however, it can be applied directly to many analyses ranging from blowdowns in simple pipes to integral LOCA tests in multiloop facilities. A refined version, called TRAC-P1A, was released to the National Energy Software Center (NESC) in March 1979. Although it still treats the same class of problems, TRAC-P1A is more efficient than TRAC-P1 and incorporates improved hydrodynamic and heat-transfer models. It also is easier to implement on various computers. TRAC-PD2 contains improved reflood and heat-transfer models and improvements in the numerical solution methods. Although a large LOCA code, it has been applied successfully to small-break problems and to the Three Mile Island incident. Distinguishing characteristics of the TRAC-PF1/MOD1 are summarized

  6. Development of prismatic sealed nickel-cadmium battery, 2000PF

    Energy Technology Data Exchange (ETDEWEB)

    Arahi,; Kazuo,; Yoshimura, Hideaki; Takeshima, Kenji; Kawamura, Chiaki

    1988-10-21

    Though, as for the sealed Ni-Cd battery, that of cylindrical form has been majorly used, that of prismatic form is heightened in needs, with the portable electronic appliances made smaller and thinner, for which needs a new type battery 2000 PF, by new production process technology and components, was developed. As compared with the past cylindrical sealed Ni-Ca batter, generally less than 100Wh/l in energy density, the new one is higher and 133Wh/l in it, with the achievement of a 17 to 34% lightening in weight. That heightening in energy density was realized by the optimized design of lamination structure, availing of the advantage not to necessitate the electrode to be wound in a spiral form, as necessary in the cylindrical battery. While as the sealing by caulking can not be adopted like the cylindrical battery, a precise welding technique by laser was established. The assembly line is of an almost unmanned on-line computer control system. The charge and discharge characteristics, etc. were indicated in detail. 11 figures, 1 table.

  7. Plasmodium falciparum chloroquine resistance transporter (PfCRT) isoforms PH1 and PH2 perturb vacuolar physiology

    OpenAIRE

    Callaghan, Paul S.; Siriwardana, Amila; Hassett, Matthew R.; Roepe, Paul D.

    2016-01-01

    Background Recent work has perfected yeast-based methods for measuring drug transport by the Plasmodium falciparum chloroquine (CQ) resistance transporter (PfCRT). Methods The approach relies on inducible heterologous expression of PfCRT in Saccharomyces cerevisiae yeast. In these experiments selecting drug concentrations are not toxic to the yeast, nor is expression of PfCRT alone toxic. Only when PfCRT is expressed in the presence of CQ is the growth of yeast impaired, due to inward transpo...

  8. Daya Tahan Hidup Pseudomonas putida Strain Pf-20 dalam Beberapa Macam Inokulum

    Directory of Open Access Journals (Sweden)

    Yenny Wuryandari

    2004-07-01

    Full Text Available For any crop-protection agent, an efficient formulation is a necessity to translate laboratory activity into adequate field performance. There are particular challenges to be faced in formulation of biological control agents, because the active ingredient is a living organism that must be kept relatively immobile and inactive while in storage, but quickly resume its  normal metabolic processes once applied to the target site. The objective of the research was  to study survival of Pseudomonas putida strain Pf-20 in various formulations at the storage  time and germination. The twelve formulations include carriers, additives and concentration  of Pf-20. The efficacy of various formulation in maintaining the population of Pf-20 in storage was assessed. The research result showed that population of Pf 20  in the formulation  number seven was the highest, with the combination peat+talc, CMC+arginin and  concentration of Pf[20 10^10 CFU/ml. In peat+talc, CMC+arginin, Pf-20 10^10  CFU/ml based formulation the bacteria survived even up to 84 days of storage although the population declined. In all formulations, population of Pf-20 increased at the time of seed germination. At the time of seed germination, formulation number seven was the highest too.

  9. The french energy policy

    International Nuclear Information System (INIS)

    1991-01-01

    This book describes french energy policy from 1973 oil crisis till 1992. In a first part, energy consumption, domestic primary energy production, trend of independence energy ratio and costs of petroleum imports in France are presented. In a second part, long-term energy prospects and new axis of energy policy are given: trends of french energy needs, progressive substitution of fossil fuels by nuclear energy and hydroelectric power, energy policy in Common Market and cooperation with eastern Europe. In a third part, energy demand and supply are studied: energy conservation policy in housing, transport and industrial sector is developed. Power generation policy is focused on two main stakes: the choice of investments and nuclear power plants programming, the quality of electric power and the development of efficient uses and exports. A diversification between coal petroleum and natural gas is led. After the fall of petroleum prices in 1986, renewable energies have lost their competitiveness, fire wood occupies a significant place

  10. French nuclear energy policy

    International Nuclear Information System (INIS)

    Ferrari, A.; Bertel, E.

    1980-11-01

    The French energy policy is supported by a lucid view of the situation of our country and the constraints linked to the international context. This statement implies, the definition of a French policy or energy production essentially based on national resources, uranium, and especially for long term, technical know how which allows using plutonium in breeder reactors. This policy implies an effort in R and D, and industrial development of nuclear field, both in reactor construction and at all levels of fuel cycle. This coherent scientific and financial effort has been pursued since the beginning of years 60, and has placed France among the first nuclear countries in the world. Now this effort enables the mastership of a strong nuclear industry capable to assure the energy future of the country [fr

  11. French courses for Beginners

    CERN Multimedia

    HR Department

    2009-01-01

    French courses for beginners (level 0) will take place from 13 July to 27 August 2009. •\tTimetable: Mondays, Tuesdays, Wednesdays, Thursdays (11:00 to 13:00 or 13:30 to 15:30) •\tDuration: 56 hours (8 hours a week) •\tPrice: 728 CHF For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Dumeaux, tel. 78144.

  12. French courses for Beginners

    CERN Multimedia

    HR Department

    2009-01-01

    French courses for beginners (level 0) will take place from 13 July to 27 August 2009. •\tTimetable: Mondays, Tuesdays, Wednesdays, Thursdays (11:00 to 13:00 or 13:30 to 15:30) •\tDuration: 56 hours (8 hours a week) •\tPrice: 728 CHF For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Dumeaux: Tel. 78144.

  13. French courses for Beginners

    CERN Multimedia

    HR Department

    2009-01-01

    French courses for beginners (level 0) will take place from 13 July to 27 August 2009. •\tTimetable: Mondays, Tuesdays, Wednesdays, Thursdays (11.00 to 13.00 or 13.30 to 15.30) •\tDuration: 56 hours (8 hours a week) •\tPrice: 728 CHF For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Dumeaux : Tel. 78144.

  14. Accuracy of PfHRP2 versus Pf-pLDH antigen detection by malaria rapid diagnostic tests in hospitalized children in a seasonal hyperendemic malaria transmission area in Burkina Faso

    OpenAIRE

    Maltha, Jessica; Guiraud, Issa; Lompo, Palpouguini; Kaboré, Bérenger; Gillet, Philippe; Van Geet, Chris; Tinto, Halidou; Jacobs, Jan

    2014-01-01

    Background In most sub-Saharan African countries malaria rapid diagnostic tests (RDTs) are now used for the diagnosis of malaria. Most RDTs used detect Plasmodium falciparum histidine-rich protein-2 (PfHRP2), though P. falciparum-specific parasite lactate dehydrogenase (Pf-pLDH)-detecting RDTs may have advantages over PfHRP2-detecting RDTs. Only few data are available on the use of RDTs in severe illness and the present study compared Pf-pLDH to PfHRP2-detection. Methods Hospitalized children...

  15. French experience with electropolishing

    International Nuclear Information System (INIS)

    Saurin, P.; Weber, C.; Brissaud, A.; Gouillardou, G.

    1989-01-01

    Among the various techniques to minimize corrosion products deposition on out of core areas, surface polishing has been researched. The attention of French partners was drawn to this technique and a test was conducted at Chinon B1 NPP in 1984 using six manway covers with various surface finishing (mechanical polishing, electropolishing, mechanical plus electropolishing/on reference). On the basis of the good results obtained and with beneficial cost considerations the electropolishing of SGCH has been decided for new EDF reactors. Once the decision was made feasibility and qualifications programs were developed. Taking into account the promising results obtained, EDF asked FRAMATOME to perform the first electropolishing operation on one steam generator channel head at Nogent 1 in 1987. Since 1988 the French experience consists of the electropolishing of 4SG at Nogent 2, 4SG at Cattenom 3, 4SG at Penly 1 and 4SG at Golfech 1 (NPP), and is perfectly satisfactory. The industrial operation provides excellent polishing and does not create undesired effects. The French partners are now thinking of a new device which could be realised at FRAMATOME especially for steam generator replacement. (author)

  16. Language Training: French

    CERN Multimedia

    Françoise Benz

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training' form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt.General and Professional French Courses The next session will take place from 26 April to 02 July 2004. These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: Tel. 73127. Writing Professional Documents in French The next session will take place from 26 April to 02 July 2004. This course is designed for people with a good level of spoken French. Duration: 30 hours Price: 660 CHF (for 8 students) For further information and registra...

  17. Science Diplomacy: French Experience

    Directory of Open Access Journals (Sweden)

    Alexei V. Shestopal

    2016-01-01

    Full Text Available The article deals with the formulation in France in the early twenty-first century of a new kind of diplomacy - science diplomacy. It studies the reasons for this process and its problems. On the one hand, the French foreign policy doctrine presupposes an ability to exercise certain influence on its international partners. However, its goals in this area are reduced to mere survival under conditions dictated by other countries. Modern trends in the world of science, which lead to integration, force to reconsider the attitude towards staff training, to research itself, and to its place and role in politics and diplomacy. However, an achievement of the French political class is an understanding of the main aspects of what is happening. This understanding leads to the search for ways to adapt to the new situation. At the same time, diplomats can operate only with those resources that are available to them. Competition with the US, China and other countries for scientific personnel and achievements cannot be won by diplomatic means alone, without backing by appropriate legal, economic and other efforts which provide favorable conditions for winning the competition. The main causes of France's unfavorable position in the struggle for an independent science are economic and political. It is they that lead to conditions, which prohibit French scientists to live up to their potential at home.

  18. REPLACEMENT OF FRENCH CARDS

    CERN Multimedia

    Human Resources Division

    2001-01-01

    The French Ministry of Foreign Affairs has informed the Organization that it is shortly to replace all diplomatic cards, special cards and employment permits ('attestations de fonctions') now held by members of the personnel and their families. Between 2 July and 31 December 2001, these cards are to be replaced by secure, computerized equivalents. A 'personnel office' stamped photocopy of the old cards may continue to be used until 31 December 2001. For the purposes of the handover, members of the personnel must go personally to the cards office (33/1-015), between 8:30 and 12:30, in order to fill a 'fiche individuelle' form (in black ink only), which has to be personally signed by themselves and another separately signed by members of their family, taking the following documents for themselves and members of their families already in possession of a French card : A recent identity photograph in 4.5 cm x 3.5 cm format (signed on the back) The French card in their possession an A4 photocopy of the same Fre...

  19. Language Training - French Training

    CERN Document Server

    2007-01-01

    General and Professional French Courses The next session will take place from 29 January to 30 March 2007. These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz : Tel. 73127. Writing Professional Documents in French The next session will take place from 29 January to 30 March 2007. This course is designed for people with a good level of spoken French. Duration: 30 hours Price: 660 CHF (for 8 students) For further information and registration, please consult our Web pages:   http://cern.ch/Training or contact Mrs. Benz : Tel. 73127. Writing Professional Documents in English The next session will take place from January to June 2007 (break at Easter). This course is designed for people with a good level of spoken English. Duration: 30 hours Price: 660 CHF (for 8 students) Timetable will be fixed after discussion with the students. For registratio...

  20. Pf16 and phiPMW: Expanding the realm of Pseudomonas putida bacteriophages.

    Directory of Open Access Journals (Sweden)

    Damian J Magill

    Full Text Available We present the analysis of two novel Pseudomonas putida phages, pf16 and phiPMW. Pf16 represents a peripherally related T4-like phage, and is the first of its kind infecting a Pseudomonad, with evidence suggesting cyanophage origins. Extensive divergence has resulted in pf16 occupying a newly defined clade designated as the pf16-related phages, lying at the interface of the Schizo T-Evens and Exo T-Evens. Recombination with an ancestor of the P. putida phage AF is likely responsible for the tropism of this phage. phiPMW represents a completely novel Pseudomonas phage with a genome containing substantial genetic novelty through its many hypothetical proteins. Evidence suggests that this phage has been extensively shaped through gene transfer events and vertical evolution. Phylogenetics shows that this phage has an evolutionary history involving FelixO1-related viruses but is in itself highly distinct from this group.

  1. Implantation of TRAC-PF1 computer code of VAX-11/750

    International Nuclear Information System (INIS)

    Madeira, A.A.; Souza Gouvea, L. de; Galetti, M.R.S.

    1988-01-01

    The implantation of TRAC-PF1 code, IBM version, in VAX-11/750 is described. This work provides Reator Department with an advanced best-estimate tool to perform loss-of-coolant accident analysis. (Author) [pt

  2. Anisotropic p-f mixing mechanism explaining anomalous magnetic properties in Ce monopnictides

    International Nuclear Information System (INIS)

    Takahashi, H.; Kasuya, T.

    1985-01-01

    The crystal-field splittings in CeP, PrP and NdP are calculated by considering the point-charge Coulomb interaction, the intra-atomic d-f Coulomb interaction, and the p-f and d-f mixings. The p-f mixing mechanisms, not only between the occupied 4f states and the conduction bands, but also between the unoccupied 4f states and the valence bands make an important contribution to the crystal-field splitting. The fact that the crystal-field potential in CeP is smaller than those in PrP and NdP is due to the occupied 4f level in CeP being shallower. The values of the Slater-Koster integrals, (pfσ) and (pfπ), are determined uniquely from the crystal-field fitting for PrP and NdP. (author)

  3. [Application study on PHI and 16PF and SCL-90 for freshman's psychology inspection].

    Science.gov (United States)

    Niu, Peng

    2009-07-01

    To explore the effect of application of the measurement table of PHI and 16PF and SCL-90 for freshmen psychology inspection. The measurement tables of PHI and 16PF for psychology inspection of freshmen of 2004-2007 years were used to sift crisis intervention objects. Continuous four years test showed certain stability, in addition to excited factors,the scores of Freshmen's PHI factors were more lower than normal. The incidence rates of mental problems screened by PHI table were very low and 3-5 serious-mental-problem students weren't detected. The problem can be resolved by the application of PHI combined with 16PF through remesuring the suspected cases by SCL-90. The combinative application of PHI, 16PF and SCL-90 would be better.

  4. Industrial engineering studies for the manufacture of the ITER PF coils

    International Nuclear Information System (INIS)

    Libeyre, P.; Decool, P.; Guerin, O.; Perrella, M.; Bourquard, A.

    2007-01-01

    Industrial studies have been carried out in Europe to prepare the manufacture of the five poloidal field (PF) coils, which will be manufactured on the ITER site. A first study, carried out by Ansaldo Superconduttori, addressed the manufacturing sequence, assuming the manufacture of the PF coils inside the two buildings which will further host the cryogenic system. A second study, carried out by Alstom investigated how to achieve the manufacture of some crucial points. A new layout of the manufacturing line was proposed, aiming at manufacture of the PF2-6 coils within 36 months. A recent study performed by Alstom, assumes the manufacture of the PF coils in a single dedicated building, releasing so the constraint of meeting the deadline fixed in ITER reference scheme by the starting point of installation of the cryogenic components

  5. Feasibility analysis of fuzzy logic control for ITER Poloidal field (PF) AC/DC converter system

    Energy Technology Data Exchange (ETDEWEB)

    Hassan, Mahmood Ul; Fu, Peng [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); University of Science and Technology of China (China); Song, Zhiquan, E-mail: zhquansong@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Chen, Xiaojiao [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); University of Science and Technology of China (China); Zhang, Xiuqing [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Humayun, Muhammad [Shanghai Jiaotong University (China)

    2017-05-15

    Highlights: • The implementation of the Fuzzy controller for the ITER PF converter system is presented. • The comparison of the FLC and PI simulation are investigated. • The FLC single and parallel bridge operation are presented. • Fuzzification and Defuzzification algorithms are presented using FLC controller. - Abstract: This paper describes the feasibility analysis of the fuzzy logic control to increase the performance of the ITER poloidal field (PF) converter systems. A fuzzy-logic-based controller is designed for ITER PF converter system, using the traditional PI controller and Fuzzy controller (FC), the dynamic behavior and transient response of the PF converter system are compared under normal operation by analysis and simulation. The analysis results show that the fuzzy logic control can achieve better operation performance than PI control.

  6. PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum

    DEFF Research Database (Denmark)

    Jiang, Lubin; Mu, Jianbing; Zhang, Qingfeng

    2013-01-01

    The variant antigen Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), which is expressed on the surface of P. falciparum-infected red blood cells, is a critical virulence factor for malaria. Each parasite has 60 antigenically distinct var genes that each code for a different PfEMP1...... parasite nuclei and their expression as proteins on the surface of individual infected red blood cells. PfSETvs-dependent H3K36me3 is present along the entire gene body, including the transcription start site, to silence var genes. With low occupancy of PfSETvs at both the transcription start site of var...... protein. During infection the clonal parasite population expresses only one gene at a time before switching to the expression of a new variant antigen as an immune-evasion mechanism to avoid the host antibody response. The mechanism by which 59 of the 60 var genes are silenced remains largely unknown...

  7. PF4-HIT antibody (KKO) complexes activate broad innate immune and inflammatory responses.

    Science.gov (United States)

    Haile, Lydia A; Rao, Roshni; Polumuri, Swamy K; Arepally, Gowthami M; Keire, David A; Verthelyi, Daniela; Sommers, Cynthia D

    2017-11-01

    Heparin-induced thrombocytopenia (HIT) is an immune-mediated complication of heparin anticoagulation therapy resulting in thrombocytopenia frequently accompanied by thrombosis. Current evidence suggests that HIT is associated with antibodies developed in response to multi-molecular complexes formed by platelet factor 4 (PF4) bound to heparin or cell surface glycosaminoglycans. These antibody complexes activate platelets and monocytes typically through FcγRIIA receptors increasing the production of PF4, inflammatory mediators, tissue factor and thrombin. The influence of underlying events in HIT including complex-induced pro-inflammatory cell activation and structural determinants leading to local inflammatory responses are not fully understood. The stoichiometry and complex component requirements were determined by incubating fresh peripheral blood mononuclear cells (PBMC) with different concentrations of unfractionated heparin (H), low molecular weight heparin (LMWH), PF4- and anti-PF4-H complex antibodies (KKO). Cytokine mRNA or protein were measured by qRT-PCR or Meso Scale Discovery technology, respectively. Gene expression profile analysis for 594 genes was performed using Nanostring technology and analyzed using Ingenuity Pathway Analysis software. The data show that antibodies magnify immune responses induced in PBMCs by PF4 alone or in complex with heparin or LMWH. We propose that following induction of HIT antibodies by heparin-PF4 complexes, binding of the antibodies to PF4 is sufficient to induce a local pro-inflammatory response which may play a role in the progression of HIT. In vitro assays using PBMCs may be useful in characterizing local inflammatory and innate immune responses induced by HIT antibodies in the presence of PF4 and different sources of heparins. The findings and conclusions in this article are solely the responsibility of the authors and are not being formally disseminated by the Food and Drug Administration. Thus, they should not be

  8. About the nanostructure of the ternary system water - [BMIm]PF6 - TX-100.

    Science.gov (United States)

    Bilgili, Harun; Bürger, Matthias; Stubenrauch, Cosima; Porada, Jan H

    2016-12-15

    Many efforts have been made to formulate water-IL microemulsions. One of the most intensely studied systems is H 2 O - 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIm]PF 6 ) - 4-octylphenol polyethoxylate (TX-100) and it is not questioned that this system forms microemulsions. The nanostructures observed for traditional microemulsions are postulated with the surfactant being adsorbed at the interface such that the hydrophilic EO sides intrude into the water domains, while the hydrophobic hydrocarbon chains are immersed into [BMIm]PF 6 . However, the high polarity of [BMIm]PF 6 and the observation that [BMIm]PF 6 mixes well with oligoethylene oxides but hardly with non-polar solvents like toluene or alkanes are not in line with this picture. We re-studied the ternary system H 2 O - [BMIm]PF 6 - TX-100 by measuring phase diagrams, determining tie-lines, and carrying out ROESY NMR and PFG NMR measurements. We found that the hydrophobic part of the surfactant interacts neither with water nor with [BMIm]PF 6 , while both solvents interact with the hydrophilic part of the surfactant. We suggest that the surfactant is not adsorbed at the interface between water and the IL, but forms normal spherical or elongated micelles or even continuous aggregates with the hydrocarbon chains forming the interior of the aggregates. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Protection from radiation injury through oral administration of PF4 gene carried by attenuated salmonella

    International Nuclear Information System (INIS)

    Zhao Lihua; Liu Bin; Yu Xiaofei; Zhang Lei; Han Zhongchao

    2005-01-01

    Objective: To investigate the in vivo radiation protection effect of PF4 by oral administration of attenuated salmonella as the carrier in mice. Methods: The eukaryotic vector pIRES2-EGFP-carried PF4 gene was transferred into an aroA-autotrophic mutant of salmonella typhimurium (SL3261), which was administered orally to BALBPc mice at 1x10 8 PFu once every interval three days. At 12 hours after the third oral administration the mice were subjected to a total body irradiation (TBI) of 700 cGy by a 60 Co source. The protective effect of SL3261/PF4 was determined by detection GFP ( green fluorescence protein) expression in tissues, peripheral blood count, culture of bone marrow colony-forming cells and survival time of mice. Results: Expression of GFP could be detected in the liver, spleen, intestine, kidney, peripheral blood and bone marrow. On days 7 and 14 after irradiation, Compared to controls, there were obvious differences in number of bone marrow mononuclear cells, CFU-GM (granulocyte-macrophage colony-forming unit ) and HPP-CFC (high proliferating potential-colony-forming cells) of mice treated with SL3261/PF4 (P<0.05) as well as prolongation of the survival time. Conclusion: These data demonstrate for the first time that PF4 protects mice from TBI injury and accelerates recovery of hematopoiesis by oral administration of attenuated salmonella carrying PF4 gene. (authors)

  10. French public finances at risk?

    Directory of Open Access Journals (Sweden)

    Creel Jérôme

    2014-01-01

    Full Text Available Using descriptive evidence, this paper contributes to the debate on French public finances’ consolidation by examining the long-term sustainability of France’s fiscal position. We trace the historical trends of government’s tax receipts and expenditures. We illustrate that while the level of public expenditure in France is larger than in the Euro Area, its trend is comparable to its neighbours. French net debt is comparable to Eurozone’s while French net wealth remains positive. However, the French tax system is not progressive with only 6% of compulsory levies raised that way, and too complex. The paper then acknowledges the efficient debt management of French authorities. As a conclusion, we see no risk of future unsustainability linked to the nature or the level of current French public finances.

  11. Future of French refining

    International Nuclear Information System (INIS)

    Calvet, B.

    1993-01-01

    Over recent years, the refining industry has had to grapple with a growing burden of environmental and safety regulations concerning not only its plants and other facilities, but also its end products. At the same time, it has had to bear the effects of the reduction of the special status that used to apply to petroleum, and the consequences of economic freedom, to which we should add, as specifically concerns the French market, the impact of energy policy and the pro-nuclear option. The result is a drop in heavy fuel oil from 36 million tonnes per year in 1973 to 6.3 million in 1992, and in home-heating fuel from 37 to 18 million per year. This fast-moving market is highly competitive. The French market in particular is wide open to imports, but the refining companies are still heavy exporters for those products with high added-value, like lubricants, jet fuel, and lead-free gasolines. The competition has led the refining companies to commit themselves to quality, and to publicize their efforts in this direction. This is why the long-term perspectives for petroleum fuels are still wide open. This is supported by the probable expectation that the goal of economic efficiency is likely to soften the effects of the energy policy, which penalizes petroleum products, in that they have now become competitive again. In the European context, with the challenge of environmental protection and the decline in heavy fuel outlets, French refining has to keep on improving the quality of its products and plants, which means major investments. The industry absolutely must return to a more normal level of profitability, in order to sustain this financial effort, and generate the prosperity of its high-performance plants and equipment. 1 fig., 5 tabs

  12. [French immigration policy].

    Science.gov (United States)

    Weil, P

    1994-01-01

    From the late nineteenth century through 1974, France permitted immigration to furnish workers and to compensate for the low level of fertility. Intense immigration from North Africa, the economic crisis of the 1970s, and other factors led to policy changes in 1974. French immigration policy since 1974 has fluctuated between guaranteeing foreigners equal rights regardless of their religion, race, culture, or national origin, and attempting to differentiate among immigrants depending on their degree of assimilability to French culture. From 1974 to 1988, France had five different policies regarding whether to permit new immigration and what to do about illegal immigrants. In July 1984, the four major political parties unanimously supported a measure in Parliament that definitively guaranteed the stay in France of legal immigrants, whose assimilation thus assumed priority. Aid for return to the homeland was no longer to be widely offered, and immigration of unskilled workers was to be terminated except for those originating in European Community countries. Major changes of government in 1988 and 1993 affected only the modalities of applying these principles. The number of immigrants has fluctuated since 1974. Unskilled workers, the only category whose entrance was specifically controlled by the 1984 measures, have declined from 174,000 in 1970 to 25,000 in the early 1990s. The number of requests for political asylum declined from 60,000 in 1989 to 27,000 in 1993, and in 1991, 15,467 persons were granted refugee status. The number of immigrants of all types permitted to remain in France declined from 250,000 or 3000 per year in the early 1970s to around 110,000 at present. Although the decline is significant, it appears insufficient to the government in power since 1993. Although migratory flows are often explained as the product of imbalance in the labor market or in demographic growth, the French experience suggests that government policies, both in the sending and

  13. The French dosimetry protocol

    International Nuclear Information System (INIS)

    Dutreix, A.

    1985-01-01

    After a general introduction the protocol is divided in five sections dealing with: determination of the quality of X-ray, γ-ray and electron beams; the measuring instrument; calibration of the reference instrument; determination of the reference absorbed dose in the user's beams; determination of the absorbed dose in water at other points, in other conditions. The French protocol is not essentially different from the Nordic protocol and it is based on the experience gained in using both the American and the Nordic protocols. Therefore, only the main difference with the published protocols are discussed. (Auth.)

  14. 1001 easy French phrases

    CERN Document Server

    McCoy, Heather

    2010-01-01

    The perfect companion for tourists and business travelers in France and other places where the French language is spoken, this book offers fast, effective communication. More than 1,000 basic words, phrases, and sentences cover everything from asking directions and renting a car to ordering dinner and finding a bank.Designed as a quick reference tool and an easy study guide, this inexpensive and easy-to-use book offers completely up-to-date terms for modern telecommunications, idioms, and slang. The contents are arranged for quick access to phrases related to greetings, transportation, shoppin

  15. The french criticality handbook

    International Nuclear Information System (INIS)

    Maubert, L.; Puit, J.C.

    1987-01-01

    The french criticality handbook, published in 1978 by the ''Commissariat a l'Energie Atomique'', is presented with the main targets aimed by the writer and the main choices taken relating to fissile mediums, reflection conditions, dilution curves. The validation of the critical values is presented as one of the most important aspects of this handbook which is mainly intended, in the mind of the author, to specialists well advertised in the field of criticality. The complements which have been introduced since 1978 and those which are foreseen in a near future are also detailed. (author)

  16. French in Culinary World

    OpenAIRE

    Rila Hilma

    2011-01-01

    More than million foods have been made by people from all over the world in the latest years. People now try to create new cooks and make some creativity on it. Then, cooking which the field is culinary has become an art because it needs an artistic value to decorate the food, a good taste and proper technique in processing delicious food in order to make it a masterpiece. French culinary is as famous as the Eiffel tower in the heart of the country, Paris. Most of fine dining international re...

  17. FRENCH PROTOCOL CARDS

    CERN Multimedia

    Division du Personnel

    1999-01-01

    Senior officials, holders of FRENCH PROTOCOL cards (blue cards) due to expire on 31.12.1999, are requested to return these cards and those of family members, for extension to:Bureau des cartes, bâtiment 33.1-025Should the 3 spaces for authentication on the back of the card be full, please enclose 2 passport photographs for a new card.In the case of children aged 14 and over, an attestation of dependency and a school certificate should be returned with the card.Personnel DivisionTel. 79494/74683

  18. FRENCH PROTOCOL CARDS

    CERN Multimedia

    Human Resources Division

    2000-01-01

    Senior officials, holders of FRENCH PROTOCOL cards (blue cards) due to expire on 31.12.2000, are requested to return these cards and those of family members, for extension to: Bureau des cartes, Bât 33.1-009/1-015 Should the three spaces for authentication on the back of the card be full, please enclose two passport photographs for a new card. In the case of children aged 14 and over, an attestation of dependency and a school certificate should be returned with the card.

  19. CLEANING OF FRENCH SITES

    CERN Multimedia

    Mauro Nonis

    2002-01-01

    In the last two weeks some cleaning problems have been remarked in several CERN buildings on the French part of CERN sites. This is mainly due to the start up of the new cleaning contract from the 1st July. These problems are not related to a budgetary reduction of the activity. We excuse for the malfunctions that have been created to CERN community and we assure you that we have taken all the needed measures to solve the problem in the shortest delay. Mauro Nonis (ST/FM)

  20. French electricity results 2002

    International Nuclear Information System (INIS)

    2002-01-01

    RTE, the manager of the French power system, announces a high increase in electricity exports to the other countries of the European Union in 2002. In France, the year 2002 was marked by stable power consumption, but a noteworthy increase in generation due to the rise of exports. In 2002, the RTE network conveyed 512.3 billion kWh (TWh) versus 503.1 billion kWh (TWh) in 2001, an increase of 1.8%. Overall French exports made considerable strides forward from 72.9 TWh in 2001 to 80.6 TWh in 2002, i.e. 10.6% more than in 2001. On the other hand, overall French imports fell substantially, from 4.4 TWh in 2001 to 3.8 TWh in 2002, or a drop of about 14%. In all, the export balance came to 76.8 TWh in 2002, versus 68.5 TWh in 2001, i.e. a rise of 12%. On Sunday, 22 December 2002, the historical record of the capacity export balance with a value of 13,277 MW, up 2.2%, was bettered. The particularly mild weather conditions in 2002 led to a drop in heating-related consumption, evaluated at 7 billion kWh compared with the prior year. A slight upturn in industrial consumption was to be noted, from 92.7 TWh in 2001 to 93.2 TWh in 2002, i.e. a growth of 0.5%. Total French consumption thus rose in 2002 to 448.7 TWh. Total consumption, adjusted for climate contingencies, showed a rise of 1.6% in 2002. French power producers showed an increase of nearly 2% and the first wind farm was connected to the power transmission network. French electricity output came to 532.9 TWh in 2002, a growth of 1.9%. This increase is divided up between nuclear generation, up 4%, and conventional thermal generation, on the rise by 15.3%. The substantial share of thermal generation can be explained by a correlative drop in hydro generation (less 16.6% compared with 2001) mainly due to extremely low water availability observed during the first months of the year. With 415.5 TWh in output, nuclear power plants provided 78% of French generation, fossil-fired power plants 9.9% with an output of 52.9 TWh

  1. The French nuclear context

    International Nuclear Information System (INIS)

    Havard, J.; Israel, M.

    1977-01-01

    The mean- and longer-range energy needs, that can be now forecasted in France, are analyzed, together with the special character of the French energy market. A resort to nuclear power is first shown to be necessary to limit the increase in the demand for imported fossil fuels, then this resort is shown to offer some real possibilities. The energy balance proves that the industrial stage of power plant construction is reached. The conditions of realization of the program have been settled with a set of provisions that render the risk and environmental impact as negligible as possible [fr

  2. Evidence for validity and reliability of a french version of the FAAM

    Directory of Open Access Journals (Sweden)

    Ballabeni Pierluigi

    2011-02-01

    Full Text Available Abstract Background The Foot and Ankle Ability Measure (FAAM is a self reported questionnaire for patients with foot and ankle disorders available in English, German, and Persian. This study plans to translate the FAAM from English to French (FAAM-F and assess the validity and reliability of this new version. Methods The FAAM-F Activities of Daily Living (ADL and sports subscales were completed by 105 French-speaking patients (average age 50.5 years presenting various chronic foot and ankle disorders. Convergent and divergent validity was assessed by Pearson's correlation coefficients between the FAAM-F subscales and the SF-36 scales: Physical Functioning (PF, Physical Component Summary (PCS, Mental Health (MH and Mental Component Summary (MCS. Internal consistency was calculated by Cronbach's Alpha (CA. To assess test re-test reliability, 22 patients filled out the questionnaire a second time to estimate minimal detectable changes (MDC and intraclass correlation coefficients (ICC. Results Correlations for FAAM-F ADL subscale were 0.85 with PF, 0.81 with PCS, 0.26 with MH, 0.37 with MCS. Correlations for FAAM-F Sports subscale were 0.72 with PF, 0.72 with PCS, 0.21 with MH, 0.29 with MCS. CA estimates were 0.97 for both subscales. Respectively for the ADL and Sports subscales, ICC were 0.97 and 0.94, errors for a single measure were 8 and 10 points at 95% confidence and the MDC values at 95% confidence were 7 and 18 points. Conclusion The FAAM-F is valid and reliable for the self-assessment of physical function in French-speaking patients with a wide range of chronic foot and ankle disorders.

  3. Invitation Refusals in Cameroon French and Hexagonal French

    Science.gov (United States)

    Farenkia, Bernard Mulo

    2015-01-01

    Descriptions of regional pragmatic variation in French are lacking to date the focus has been on a limited range of speech acts, including apologies, requests, compliments and responses to compliments. The present paper, a systematic analysis of invitation refusals across regional varieties of French, is designed to add to the research on…

  4. Language Training: French Training

    CERN Multimedia

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. LANGUAGE TRAINING Françoise Benz tel. 73127 language.training@cern.ch General and Professional French Courses The next session will take place from 26 April to 02 July 2004. These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: Tel. 73127. Writing Professional Documents in French The next session will take place from 26 April to 02 July 2004. This course is designed for people with a good level of s...

  5. Language Training: French Training

    CERN Multimedia

    2004-01-01

    If you wish to participate in one of the following courses, please discuss with your supervisor and apply electronically directly from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an "application for training" form available from your Divisional Secretariat or from your DTO (Divisional Training Officer). Applications will be accepted in the order of their receipt. LANGUAGE TRAINING Françoise Benz tel. 73127 language.training@cern.ch General and Professional French Courses The next session will take place from 26 April to 02 July 2004. These courses are open to all persons working on the Cern site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: Tel. 73127. Writing Professional Documents in French The next session will take place from 26 April to 02 July 2004. This course is designed for people with a good level...

  6. Spotlight: French Polynesia.

    Science.gov (United States)

    May, J F

    1988-01-01

    French Polynesia is a group of 4 archipelagos in the South Pacific with an estimated 1987 population of 176,600. Its people are mainly Tahitians, Polynesians, Chinese, Europeans, and persons of mixed heritage. More than half of the population live in the Society Islands. About half of the population is less than 20 years old and slightly more than 5% is older than 60. Due to a recent decline in fertility, the rate of natural increase is moderate--about 2.5% annually. In the early 1980s, about two thirds of women in Tahiti aged 15-49 used a modern method of contraception. It remains to be seen whether this pattern will spread to the entire area. Projections by the World Bank, assuming little decline in mortality, yield a total population of 400,000 by the year 2030. The major challenge for French Polynesia is to develop the many small islands spread across an ocean territory half the size of the contiguous 48 states of the U.S. Tourist-related activities have replaced traditional income-generating such as production of coconuts, mother-of-pearl, and vanilla. The value of exports from the area make up only 5% of the value of imports. To extract the potentially huge food and mineral resources from the ocean, enormous infusions of capital will be necessary.

  7. The French capacity mechanism

    International Nuclear Information System (INIS)

    2014-01-01

    The French capacity mechanism has been design to ensure security of supply in the context of the energy transition. This energy transition challenges the electricity market design with several features: peak load growth, the development of renewables, demand response,... To ensure security of supply in this context, a capacity mechanism is being implemented in France. It is a market wide capacity obligation on electricity suppliers, based on market principles. Suppliers are responsible for forecasting their obligation, which corresponds to their contribution to winter peak load, and must procure enough capacity certificates to meet their obligations. Capacity certificates are granted to capacities through a certification process, which assesses their contribution to security of supply on the basis of availability commitments. This certification process is technology neutral and performance based, associated with controls and penalties in case of non compliance. Demand Side is fully integrated in the market, either through the reduction of suppliers' capacity obligation or direct participation after certification. In addition to the expected benefits in terms of security of supply, the French capacity market will foster the development of demand response. The participation of foreign capacities will require adaptations which are scheduled in a road-map, and could pave the way for further European integration of energy policies. (authors)

  8. French intensive truck garden

    Energy Technology Data Exchange (ETDEWEB)

    Edwards, T D

    1983-01-01

    The French Intensive approach to truck gardening has the potential to provide substantially higher yields and lower per acre costs than do conventional farming techniques. It was the intent of this grant to show that there is the potential to accomplish the gains that the French Intensive method has to offer. It is obvious that locally grown food can greatly reduce transportation energy costs but when there is the consideration of higher efficiencies there will also be energy cost reductions due to lower fertilizer and pesticide useage. As with any farming technique, there is a substantial time interval for complete soil recovery after there have been made substantial soil modifications. There were major crop improvements even though there was such a short time since the soil had been greatly disturbed. It was also the intent of this grant to accomplish two other major objectives: first, the garden was managed under organic techniques which meant that there were no chemical fertilizers or synthetic pesticides to be used. Second, the garden was constructed so that a handicapped person in a wheelchair could manage and have a higher degree of self sufficiency with the garden. As an overall result, I would say that the garden has taken the first step of success and each year should become better.

  9. Wind: French revolutions

    International Nuclear Information System (INIS)

    Jones, C.

    2006-01-01

    Despite having the second best wind resources in Europe after the UK, the wind industry in France lags behind its European counterparts with just 6 W of installed wind capacity per person. The electricity market in France is dominated by the state-owned Electricite de France (EdF) and its nuclear power stations. However, smaller renewable generators are now in theory allowed access to the market and France has transposed the EU renewables directive into national law. The French governement has set a target of generating 10,000 MW of renewable capacity by 2010. The announcement of an increased feed-in tariff and the introduction of 'development zones' (ZDEs) which could allow fast-tracking of planning for wind projects are also expected to boost wind projects. But grid access and adminstrative burdens remain major barriers. In addition, French politicians and local authorities remain committed to nuclear, though encouraged by the European Commission, wind is beginning to gain acceptance; some 325 wind farms (representing 1557 MW of capacity) were approved between February 2004 and January 2005. France is now regarded by the international wind energy sector as a target market. One of France's leading independent wind developers and its only listed wind company, Theolia, is expected to be one of the major beneficiaries of the acceleration of activity in France, though other companies are keen to maximise the opportunities for wind. France currently has only one indigenous manufacturer of wind turbines, but foreign suppliers are winning orders

  10. Smart grids - French Expertise

    International Nuclear Information System (INIS)

    2015-11-01

    The adaptation of electrical systems is the focus of major work worldwide. Bringing electricity to new territories, modernizing existing electricity grids, implementing energy efficiency policies and deploying renewable energies, developing new uses for electricity, introducing electric vehicles - these are the challenges facing a multitude of regions and countries. Smart Grids are the result of the convergence of electrical systems technologies with information and communications technologies. They play a key role in addressing the above challenges. Smart Grid development is a major priority for both public and private-sector actors in France. The experience of French companies has grown with the current French electricity system, a system that already shows extensive levels of 'intelligence', efficiency and competitiveness. French expertise also leverages substantial competence in terms of 'systems engineering', and can provide a tailored response to meet all sorts of needs. French products and services span all the technical and commercial building blocks that make up the Smart Grid value chain. They address the following issues: Improving the use and valuation of renewable energies and decentralized means of production, by optimizing the balance between generation and consumption. Strengthening the intelligence of the transmission and distribution grids: developing 'Supergrid', digitizing substations in transmission networks, and automating the distribution grids are the focus of a great many projects designed to reinforce the 'self-healing' capacity of the grid. Improving the valuation of decentralized flexibilities: this involves, among others, deploying smart meters, reinforcing active energy efficiency measures, and boosting consumers' contribution to grid balancing, via practices such as demand response which implies the aggregation of flexibility among residential, business, and/or industrial sites. Addressing current technological challenges, in

  11. Plasmodium falciparum chloroquine resistance transporter (PfCRT) isoforms PH1 and PH2 perturb vacuolar physiology.

    Science.gov (United States)

    Callaghan, Paul S; Siriwardana, Amila; Hassett, Matthew R; Roepe, Paul D

    2016-03-31

    Recent work has perfected yeast-based methods for measuring drug transport by the Plasmodium falciparum chloroquine (CQ) resistance transporter (PfCRT). The approach relies on inducible heterologous expression of PfCRT in Saccharomyces cerevisiae yeast. In these experiments selecting drug concentrations are not toxic to the yeast, nor is expression of PfCRT alone toxic. Only when PfCRT is expressed in the presence of CQ is the growth of yeast impaired, due to inward transport of chloroquine (CQ) via the transporter. During analysis of all 53 known naturally occurring PfCRT isoforms, two isoforms (PH1 and PH2 PfCRT) were found to be intrinsically toxic to yeast, even in the absence of CQ. Additional analysis of six very recently identified PfCRT isoforms from Malaysia also showed some toxicity. In this paper the nature of this yeast toxicity is examined. Data also show that PH1 and PH2 isoforms of PfCRT transport CQ with an efficiency intermediate to that catalyzed by previously studied CQR conferring isoforms. Mutation of PfCRT at position 160 is found to perturb vacuolar physiology, suggesting a fitness cost to position 160 amino acid substitutions. These data further define the wide range of activities that exist for PfCRT isoforms found in P. falciparum isolates from around the globe.

  12. PROMIS PF CAT Outperforms the ODI and SF-36 Physical Function Domain in Spine Patients.

    Science.gov (United States)

    Brodke, Darrel S; Goz, Vadim; Voss, Maren W; Lawrence, Brandon D; Spiker, William Ryan; Hung, Man

    2017-06-15

    The Oswestry Disability Index v2.0 (ODI), SF36 Physical Function Domain (SF-36 PFD), and PROMIS Physical Function CAT v1.2 (PF CAT) questionnaires were prospectively collected from 1607 patients complaining of back or leg pain, visiting a university-based spine clinic. All questionnaires were collected electronically, using a tablet computer. The aim of this study was to compare the psychometric properties of the PROMIS PF CAT with the ODI and SF36 Physical Function Domain in the same patient population. Evidence-based decision-making is improved by using high-quality patient-reported outcomes measures. Prior studies have revealed the shortcomings of the ODI and SF36, commonly used in spine patients. The PROMIS Network has developed measures with excellent psychometric properties. The Physical Function domain, delivered by Computerized Adaptive Testing (PF CAT), performs well in the spine patient population, though to-date direct comparisons with common measures have not been performed. Standard Rasch analysis was performed to directly compare the psychometrics of the PF CAT, ODI, and SF36 PFD. Spearman correlations were computed to examine the correlations of the three instruments. Time required for administration was also recorded. One thousand six hundred seven patients were administered all assessments. The time required to answer all items in the PF CAT, ODI, and SF-36 PFD was 44, 169, and 99 seconds. The ceiling and floor effects were excellent for the PF CAT (0.81%, 3.86%), while the ceiling effects were marginal and floor effects quite poor for the ODI (6.91% and 44.24%) and SF-36 PFD (5.97% and 23.65%). All instruments significantly correlated with each other. The PROMIS PF CAT outperforms the ODI and SF-36 PFD in the spine patient population and is highly correlated. It has better coverage, while taking less time to administer with fewer questions to answer. 2.

  13. Evaluation of the siRNA PF-04523655 versus ranibizumab for the treatment of neovascular age-related macular degeneration (MONET Study)

    DEFF Research Database (Denmark)

    Nguyen, Quan Dong; Schachar, Ronald A; Nduaka, Chudy I

    2012-01-01

    To evaluate the efficacy of different dosing paradigms of PF-04523655 (PF) versus ranibizumab (comparator) in subjects with neovascular age-related macular degeneration (AMD).......To evaluate the efficacy of different dosing paradigms of PF-04523655 (PF) versus ranibizumab (comparator) in subjects with neovascular age-related macular degeneration (AMD)....

  14. Development of the French Photovoltaic Program

    Energy Technology Data Exchange (ETDEWEB)

    Brunet, M.

    1980-07-01

    The French photovoltaic research program is reviewed, listing companies involved. Projections of module and system costs are discussed. French industrial experience in photovoltaics is reviewed and several French systems operating in developing countries are mentioned. (MHR)

  15. General and Professional French Courses

    CERN Multimedia

    HR Department

    2010-01-01

    The next session will take place from 11 October to 17 December 2010. These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Nathalie Dumeaux, tel. 78144. NEW COURSES Specific French courses -Exam preparation/ We are now offering specific courses in English and French leading to a recognised external examination (e.g. DELF 1 and 2). If you are interested in following one of these courses and have at least an intermediate level of French, please enrol through the following link: French courses or contact: Lucette Fournier, tel.  73483 (French courses).

  16. Status of French reactors

    Energy Technology Data Exchange (ETDEWEB)

    Ballagny, A. [Commissariat a l`Energie Atomique, Saclay (France)

    1997-08-01

    The status of French reactors is reviewed. The ORPHEE and RHF reactors can not be operated with a LEU fuel which would be limited to 4.8 g U/cm{sup 3}. The OSIRIS reactor has already been converted to LEU. It will use U{sub 3}Si{sub 2} as soon as its present stock of UO{sub 2} fuel is used up, at the end of 1994. The decision to close down the SILOE reactor in the near future is not propitious for the start of a conversion process. The REX 2000 reactor, which is expected to be commissioned in 2005, will use LEU (except if the fast neutrons core option is selected). Concerning the end of the HEU fuel cycle, the best option is reprocessing followed by conversion of the reprocessed uranium to LEU.

  17. The French nuclear programme

    International Nuclear Information System (INIS)

    Bacher, Pierre

    1987-01-01

    France has a civil nuclear power generation programme second only to the USA with 49 nuclear units in operation and 13 under construction. The units in service are described. These include 33 PWR 900 MW and 9 PWR 1300 MW units. The electricity consumption and generation in France is illustrated. The absence of a powerful anti-nuclear lobby and two main technical options have contributed to the success of the French nuclear programme. These are the PWR design and the plant standardization policy which allows the setting up of an effective industrial complex (eg for analysis of operating conditions and of safety and reliability information). The programme and the reasons for its success are reviewed. Research programmes and future plans are also discussed. (UK)

  18. French courses for beginners

    CERN Multimedia

    Françoise Benz

    2006-01-01

    If you wish to participate in one of the following courses, please tell to your supervisor and apply electronically from the course description pages that can be found on the Web at: http://www.cern.ch/Training/ or fill in an 'application for training'form available from your Departmental Secretariat or from your DTO (Departmental Training Officer). Applications will be accepted in the order in which they are received. French courses for beginners (level 0) From 17 July to 31 August 2006. Mondays, Tuesdays, Wednesdays and Thursdays(8 hours a week / between 11.00 and 15.30) Duration: 56 hours Price: 728 CHF For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Mrs. Benz: Tel. 73127.

  19. Status of French reactors

    International Nuclear Information System (INIS)

    Ballagny, A.

    1997-01-01

    The status of French reactors is reviewed. The ORPHEE and RHF reactors can not be operated with a LEU fuel which would be limited to 4.8 g U/cm 3 . The OSIRIS reactor has already been converted to LEU. It will use U 3 Si 2 as soon as its present stock of UO 2 fuel is used up, at the end of 1994. The decision to close down the SILOE reactor in the near future is not propitious for the start of a conversion process. The REX 2000 reactor, which is expected to be commissioned in 2005, will use LEU (except if the fast neutrons core option is selected). Concerning the end of the HEU fuel cycle, the best option is reprocessing followed by conversion of the reprocessed uranium to LEU

  20. Heparin-independent, PF4-dependent binding of HIT antibodies to platelets: implications for HIT pathogenesis.

    Science.gov (United States)

    Padmanabhan, Anand; Jones, Curtis G; Bougie, Daniel W; Curtis, Brian R; McFarland, Janice G; Wang, Demin; Aster, Richard H

    2015-01-01

    Antibodies specific for platelet factor 4 (PF4)/heparin complexes are the hallmark of heparin-induced thrombocytopenia and thrombosis (HIT), but many antibody-positive patients have normal platelet counts. The basis for this is not fully understood, but it is believed that antibodies testing positive in the serotonin release assay (SRA) are the most likely to cause disease. We addressed this issue by characterizing PF4-dependent binding of HIT antibodies to intact platelets and found that most antibodies testing positive in the SRA, but none of those testing negative, bind to and activate platelets when PF4 is present without any requirement for heparin (P HIT antibodies recognize PF4 in a complex with heparin, only a subset of these antibodies recognize more subtle epitopes induced in PF4 when it binds to CS, the major platelet glycosaminoglycan. Antibodies having this property could explain "delayed HIT" seen in some individuals after discontinuation of heparin and the high risk for thrombosis that persists for weeks in patients recovered from HIT. © 2015 by The American Society of Hematology.

  1. Accuracy of PfHRP2 versus Pf-pLDH antigen detection by malaria rapid diagnostic tests in hospitalized children in a seasonal hyperendemic malaria transmission area in Burkina Faso.

    Science.gov (United States)

    Maltha, Jessica; Guiraud, Issa; Lompo, Palpouguini; Kaboré, Bérenger; Gillet, Philippe; Van Geet, Chris; Tinto, Halidou; Jacobs, Jan

    2014-01-13

    In most sub-Saharan African countries malaria rapid diagnostic tests (RDTs) are now used for the diagnosis of malaria. Most RDTs used detect Plasmodium falciparum histidine-rich protein-2 (PfHRP2), though P. falciparum-specific parasite lactate dehydrogenase (Pf-pLDH)-detecting RDTs may have advantages over PfHRP2-detecting RDTs. Only few data are available on the use of RDTs in severe illness and the present study compared Pf-pLDH to PfHRP2-detection. Hospitalized children aged one month to 14 years presenting with fever or severe illness were included over one year. Venous blood samples were drawn for malaria diagnosis (microscopy and RDT), culture and complete blood count. Leftovers were stored at -80 °C and used for additional RDT analysis and PCR. An RDT targeting both PfHRP2 and Pf-pLDH was performed on all samples for direct comparison of diagnostic accuracy with microscopy as reference method. PCR was performed to explore false-positive RDT results. In 376 of 694 (54.2%) included children, malaria was microscopically confirmed. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value were 100.0, 70.9, 69.4 and 100.0%, respectively for PfHRP2-detection and 98.7, 94.0, 91.6 and 99.1%, respectively for Pf-pLDH-detection. Specificity and PPV were significantly lower for PfHRP2-detection (p <0.001). For both detection antigens, specificity was lowest for children one to five years and in the rainy season. PPV for both antigens was highest in the rainy season, because of higher malaria prevalence. False positive PfHRP2 results were associated with prior anti-malarial treatment and positive PCR results (98/114 (86.0%) samples tested). Among children presenting with severe febrile illness in a seasonal hyperendemic malaria transmission area, the present study observed similar sensitivity but lower specificity and PPV of PfHRP2 compared to Pf-pLDH-detection. Further studies should assess the diagnostic accuracy and safety of an

  2. Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens.

    Directory of Open Access Journals (Sweden)

    Andrew R Williams

    Full Text Available No vaccine has yet proven effective against the blood-stages of Plasmodium falciparum, which cause the symptoms and severe manifestations of malaria. We recently found that PfRH5, a P. falciparum-specific protein expressed in merozoites, is efficiently targeted by broadly-neutralizing, vaccine-induced antibodies. Here we show that antibodies against PfRH5 efficiently inhibit the in vitro growth of short-term-adapted parasite isolates from Cambodia, and that the EC(50 values of antigen-specific antibodies against PfRH5 are lower than those against PfAMA1. Since antibody responses elicited by multiple antigens are speculated to improve the efficacy of blood-stage vaccines, we conducted detailed assessments of parasite growth inhibition by antibodies against PfRH5 in combination with antibodies against seven other merozoite antigens. We found that antibodies against PfRH5 act synergistically with antibodies against certain other merozoite antigens, most notably with antibodies against other erythrocyte-binding antigens such as PfRH4, to inhibit the growth of a homologous P. falciparum clone. A combination of antibodies against PfRH4 and basigin, the erythrocyte receptor for PfRH5, also potently inhibited parasite growth. This methodology provides the first quantitative evidence that polyclonal vaccine-induced antibodies can act synergistically against P. falciparum antigens and should help to guide the rational development of future multi-antigen vaccines.

  3. Pregnancy-associated purpura fulminans (PF Púrpura fulminans asociada al embarazo

    Directory of Open Access Journals (Sweden)

    Gisela de la Rosa Echavez

    2005-03-01

    Full Text Available

    PF is a serious cutaneous purpuric disease, associated with an intravascular disseminated coagulation syndrome. Among its known causes, besides those of thrombophilia, are viral and bacterial infections, mostly Neisseria meningitidis. During pregnancy there are alterations in the hemostatic mechanism. However, by themselves, they have not been shown to lead to PF. The case of a 22-year-old woman who developed PF during pregnancy, presumably due to her Escherichia coli urinary tract infection, is presented including clinical, paraclinical, therapeutic and surgical aspects. She recovered but suffered amputation of the distant phalanges of three toes in the left foot 

    La púrpura fulminans (pf es una enfermedad cutánea purpúrica aguda asociada a un síndrome de coagulación intravascular diseminada (CID. Sus causas conocidas incluyen infecciones virales y bacterianas así como trombofilias. Es sabido que durante el embarazo existen alteraciones en los mecanismos hemostáticos, sin embargo, no se ha demostrado que estos fenómenos por sí solos ayuden al desarrollo de la PF. Se describe el caso de una mujer de 22 años, quien tuvo PF en circunstancias inusuales tales como el desarrollo de su cuadro durante el embarazo y el origen probable en una infección por E. coli. Se presentan los hallazgos clínicos, las intervenciones médicas y quirúrgicas y el desenlace. La paciente sobrevivió, pero hubo necesidad de amputarle las falanges distales de tres artejos del pie izquierdo.

  4. Practising French grammar a workbook

    CERN Document Server

    Dr Roger Hawkins; Towell, Richard

    2015-01-01

    This new edition of Practising French Grammar offers a set of varied and accessible exercises for developing a practical awareness of French as it is spoken and written today. The lively examples and authentic texts and cartoons have been updated to reflect current usage. A new companion website provides a wealth of additional interactive exercises to help consolidate challenging grammar points. Practising French Grammar provides concise summaries of key grammatical points at the beginning of each exercise, as well as model answers to the exercises and translations of difficult words, making i

  5. Pressure-induced phase transition of 1-butyl-3-methylimidazolium hexafluorophosphate [bmim][PF6

    Science.gov (United States)

    Takekiyo, Takahiro; Hatano, Naohiro; Imai, Yusuke; Abe, Hiroshi; Yoshimura, Yukihiro

    2011-03-01

    We have investigated the pressure-induced Raman spectral change of 1-butyl-3-methylimidazolium hexafluorophosphate ([bmim][PF6]) using Raman spectroscopy. The relative Raman intensity at 590 cm-1 of the CH2 rocking band assigned to the gauche conformer of the NCCC dihedral angle of the butyl group in the [bmim]+ cation increases when the pressure-induced liquid-crystalline phase transition occurs, while that at 610 cm-1 assigned to the trans conformer decreases. Our results show that the high-pressure phase transition of [bmim][PF6] causes the increase of the gauche conformer of the [bmim]+ cation.

  6. Analysis of the flow imbalance in the KSTAR PF cryo-circuit

    International Nuclear Information System (INIS)

    Lee, Hyun-Jung; Park, Dong-Seong; Kwag, Sang-Woo; Joo, Jae-Jun; Moon, Kyung-Mo; Kim, Nam-Won; Lee, Young-Joo; Park, Young-Min; Yang, Hyung-Lyeol

    2015-01-01

    Highlights: • Investigate of flow imbalance trend for the KSTAR PF superconducting magnet. • Flow imbalance is compared with individual magnet test and integration magnet test. • Intensifying of flow imbalance is proven from the flow monitoring in the KSTAR PF circuit. • Flow behavior is analyzed during magnet charging in the circulator circuit. • Variation of magnet outlet temperature is analyzed due to flow imbalance. - Abstract: The KSTAR PF cryo-circuit is a quasi-closed circulation system in which more than 370 g/s of supercritical helium (SHe) is circulated using a SHe circulator. The heated helium from superconducting magnet is cooled through sub cooler (4.3 K). The circulator is operated at 4.5 K and 6.5 bar, and the pressure drop of the circuit is kept at 2 bar in order to maintain the supercritical state and circulator stability. The circuit is connected with helium refrigerator system, distribution system, and supercritical magnet system. It has a hundred branches to supply supercritical helium to the poloidal field superconducting magnet. The branch was designed to optimize the operation conditions and they are grouped for one cryogenic valve has the same length within the cardinal principle of the optimization. Five cryogenic valves are installed to control the mass flow rate, and seven orifice mass flow meters, differential pressure gauges and temperature sensors were installed in front of the magnet in the distribution because upper magnet and lower magnet is symmetric theoretically. The cryogenic pipe line was manufactured with elevation about 10 m between upper magnet and lower magnet. The inlet and outlet helium feed-through were installed at the coil inside in case of KSTAR PF1–PF5 upper magnet and lower magnet. The flow imbalance is caused by void fraction and it could be changed due to manufacturing process even if it has the same length of cooling channel. This creates an imbalance among cooling channels and temperatures are

  7. Electron-capture Rates for pf-shell Nuclei in Stellar Environments and Nucleosynthesis

    Science.gov (United States)

    Suzuki, Toshio; Honma, Michio; Mori, Kanji; Famiano, Michael A.; Kajino, Toshitaka; Hidakai, Jun; Otsuka, Takaharu

    Gamow-Teller strengths in pf-shell nuclei obtained by a new shell-model Hamltonian, GXPF1J, are used to evaluate electron-capture rates in pf-shell nuclei at stellar environments. The nuclear weak rates with GXPF1J, which are generally smaller than previous evaluations for proton-rich nuclei, are applied to nucleosynthesis in type Ia supernova explosions. The updated rates are found to lead to less production of neutron-rich nuclei such as 58Ni and 54Cr, thus toward a solution of the problem of over-production of neutron-rich isotopes of iron-group nuclei compared to the solar abundance.

  8. Initial characterization of the Pf-Int recombinase from the malaria parasite Plasmodium falciparum.

    Directory of Open Access Journals (Sweden)

    Mehdi Ghorbal

    Full Text Available Genetic variation is an essential means of evolution and adaptation in many organisms in response to environmental change. Certain DNA alterations can be carried out by site-specific recombinases (SSRs that fall into two families: the serine and the tyrosine recombinases. SSRs are seldom found in eukaryotes. A gene homologous to a tyrosine site-specific recombinase has been identified in the genome of Plasmodium falciparum. The sequence is highly conserved among five other members of Plasmodia.The predicted open reading frame encodes for a ∼57 kDa protein containing a C-terminal domain including the putative tyrosine recombinase conserved active site residues R-H-R-(H/W-Y. The N-terminus has the typical alpha-helical bundle and potentially a mixed alpha-beta domain resembling that of λ-Int. Pf-Int mRNA is expressed differentially during the P. falciparum erythrocytic life stages, peaking in the schizont stage. Recombinant Pf-Int and affinity chromatography of DNA from genomic or synthetic origin were used to identify potential DNA targets after sequencing or micro-array hybridization. Interestingly, the sequences captured also included highly variable subtelomeric genes such as var, rif, and stevor sequences. Electrophoretic mobility shift assays with DNA were carried out to verify Pf-Int/DNA binding. Finally, Pf-Int knock-out parasites were created in order to investigate the biological role of Pf-Int.Our data identify for the first time a malaria parasite gene with structural and functional features of recombinases. Pf-Int may bind to and alter DNA, either in a sequence specific or in a non-specific fashion, and may contribute to programmed or random DNA rearrangements. Pf-Int is the first molecular player identified with a potential role in genome plasticity in this pathogen. Finally, Pf-Int knock-out parasite is viable showing no detectable impact on blood stage development, which is compatible with such function.

  9. Systems concepts for DOE facilities: analysis of PF/LASS data

    International Nuclear Information System (INIS)

    Bearse, R.C.; Shirk, D.G.; Marshall, R.S.; Thomas, C.C. Jr.

    1982-06-01

    We have analyzed Plutonium Facility/Los Alamos Safeguards System (PF/LASS) data for the Fast Flux Test Facility (FFTF) process. Highlights of the work are: the PF/LASS data base provides useful information for accountability purposes, some measurement code assignments appear to be in error, some other data are erroneous, and material in process (MIP) and cumulative sum (CUSUM) charts are powerful indicators of trouble areas. From these studies we recommend re-examination of instrument biases, adoption of new naming procedures for collection batches, improvement of measurement code assignment reliability, revision of round-off procedures, and strengthening of measurement control procedures

  10. French Literature Abroad: Towards an Alternative History of French Literature

    Directory of Open Access Journals (Sweden)

    Simon Gaunt

    2015-07-01

    Full Text Available What would a history of medieval literature in French that is not focused on France and Paris look like? Taking as its starting point the key role played in the development of textual culture in French by geographical regions that are either at the periphery of French-speaking areas, or alternatively completely outside them, this article offers three case studies: first of a text composed in mid-twelfth century England; then of one from early thirteenth-century Flanders; and finally from late thirteenth-century Italy. What difference does it make if we do not read these texts, and the language in which they are written, in relation to French norms, but rather look at their cultural significance both at their point of production, and then in transmission? A picture emerges of a literary culture in French that is mobile and cosmopolitan, one that cannot be tied to the teleology of an emerging national identity, and one that is a bricolage of a range of influences that are moving towards France as well as being exported from it. French itself functions as a supralocal written language (even when it has specific local features and therefore may function more like Latin than a local vernacular.

  11. English and French courses

    CERN Multimedia

    2014-01-01

    If one of your New Year’s resolutions is to learn a language, there is no excuse anymore!   You can attend one of our English or French courses and you can practise the language with a tandem partner! Cours d’anglais général et professionnel La prochaine session se déroulera du 3 mars au 27 juin 2014. Ces cours s’adressent à toute personne travaillant au CERN ainsi qu’à leur conjoint. Pour vous inscrire et voir tout le détail des cours proposés, consultez nos pages web : http://cern.ch/Training. Oral Expression The next session will take place from 3 March to 27 June 2014. This course is intended for people with a good knowledge of English who want to enhance their speaking skills. There will be an average of 8 participants in a class. Speaking activities will include discussions, meeting simulations, role-plays etc. depending on the needs of the students. Writing Profe...

  12. General and professionnal French courses

    CERN Document Server

    2013-01-01

    The next session will take place from 27 January to 4 April 2014. These courses are open to everyone working on the CERN site and to their spouses.   Oral Expression This course is aimed at students with a good knowledge of French who want to enhance their oral communication skills. Activities will include discussions, meeting simulations, role-plays, etc. The next session will take place from 27 January to 4 April 2014. Writing professional documents in French These courses are designed for non-French speakers with a very good standard of spoken French. The next session will take place from 27 January to 4 April 2014. For registration and further information on the courses, please consult our web site or contact Kerstin Fuhrmeister (70896 - language.training@cern.ch).

  13. General and professionnal French courses

    CERN Multimedia

    2013-01-01

    The next session will take place from 27 January to 4 April 2014. These courses are open to everyone working on the CERN site and to their spouses.   Oral Expression This course is aimed at students with a good knowledge of French who want to enhance their speaking skills. Speaking activities will include discussions, meeting simulations, role-plays etc. The next session will take place from 27 January to 4 April 2014. Writing professional documents in French These courses are designed for non-French speakers with a very good standard of spoken French. The next session will take place from 27 January to 4 April 2014. For registration and further information on the courses, please consult our web site or contact Kerstin Fuhrmeister (70896 - language.training@cern.ch).

  14. French switch off in protest

    CERN Document Server

    McCabe, H

    1999-01-01

    French scientists have refused to restart two synchrotron machines after the summer vacation. They are protesting at the government decision to give money to the British synchrotron project Diamond, so ending hopes of the construction of the proposed

  15. Reshuffle lifts French synchrotron hopes

    CERN Multimedia

    McCabe, H

    2000-01-01

    The sacking of Claude Allegre as research minister has raised doubts over the level of France's promised participation in the construction of Diamond but reawakened French hopes that the synchrotron Soleil may now be built (1 page).

  16. 21 CFR 169.115 - French dressing.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false French dressing. 169.115 Section 169.115 Food and... § 169.115 French dressing. (a) Description. French dressing is the separable liquid food or the..., lecithin, or polyglycerol esters of fatty acids. (d) Nomenclature. The name of the food is “French dressing...

  17. Teaching for Content: Greek Mythology in French.

    Science.gov (United States)

    Giauque, Gerald S.

    An intermediate-level university French course in Greek mythology was developed to (1) improve student skills in reading, writing, speaking, and comprehending French, (2) familiarize students with Greek mythology, and (3) prepare students to deal better with allusions to Greek mythology in French literature. The texts used are a French translation…

  18. 7 CFR 993.7 - French prunes.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false French prunes. 993.7 Section 993.7 Agriculture... Order Regulating Handling Definitions § 993.7 French prunes. French prunes means: (a) Prunes produced from plums of the following varieties of plums: French (Prune d'Agen, Petite Prune d'Agen), Coates (Cox...

  19. English Grammar for Students of French.

    Science.gov (United States)

    Morton, Jacqueline

    This grammar is a self-study manual intended to aid native speakers of English who are beginning the study of French. It is designed to supplement the French textbook, not to replace it. The common grammatical terms that are necessary for learning to speak and write French are explained in English and illustrated by examples in both French and…

  20. Plasmodium falciparum Hep1 Is Required to Prevent the Self Aggregation of PfHsp70-3.

    Directory of Open Access Journals (Sweden)

    David O Nyakundi

    Full Text Available The majority of mitochondrial proteins are encoded in the nucleus and need to be imported from the cytosol into the mitochondria, and molecular chaperones play a key role in the efficient translocation and proper folding of these proteins in the matrix. One such molecular chaperone is the eukaryotic mitochondrial heat shock protein 70 (Hsp70; however, it is prone to self-aggregation and requires the presence of an essential zinc-finger protein, Hsp70-escort protein 1 (Hep1, to maintain its structure and function. PfHsp70-3, the only Hsp70 predicted to localize in the mitochondria of P. falciparum, may also rely on a Hep1 orthologue to prevent self-aggregation. In this study, we identified a putative Hep1 orthologue in P. falciparum and co-expression of PfHsp70-3 and PfHep1 enhanced the solubility of PfHsp70-3. PfHep1 suppressed the thermally induced aggregation of PfHsp70-3 but not the aggregation of malate dehydrogenase or citrate synthase, thus showing specificity for PfHsp70-3. Zinc ions were indeed essential for maintaining the function of PfHep1, as EDTA chelation abrogated its abilities to suppress the aggregation of PfHsp70-3. Soluble and functional PfHsp70-3, acquired by co-expression with PfHep-1, will facilitate the biochemical characterisation of this particular Hsp70 protein and its evaluation as a drug target for the treatment of malaria.

  1. Identification of active Plasmodium falciparum calpain to establish screening system for Pf-calpain-based drug development

    Directory of Open Access Journals (Sweden)

    Soh Byoung

    2013-02-01

    Full Text Available Abstract Background With the increasing resistance of malaria parasites to available drugs, there is an urgent demand to develop new anti-malarial drugs. Calpain inhibitor, ALLN, is proposed to inhibit parasite proliferation by suppressing haemoglobin degradation. This provides Plasmodium calpain as a potential target for drug development. Pf-calpain, a cysteine protease of Plasmodium falciparum, belongs to calpain-7 family, which is an atypical calpain not harboring Ca2+-binding regulatory motifs. In this present study, in order to establish the screening system for Pf-calpain specific inhibitors, the active form of Pf-calpain was first identified. Methods Recombinant Pf-calpain including catalytic subdomain IIa (rPfcal-IIa was heterologously expressed and purified. Enzymatic activity was determined by both fluorogenic substrate assay and gelatin zymography. Molecular homology modeling was carried out to address the activation mode of Pf-calpain in the aspect of structural moiety. Results Based on the measurement of enzymatic activity and protease inhibitor assay, it was found that the active form of Pf-calpain only contains the catalytic subdomain IIa, suggesting that Pf-calpain may function as a monomeric form. The sequence prediction indicates that the catalytic subdomain IIa contains all amino acid residues necessary for catalytic triad (Cys-His-Asn formation. Molecular modeling suggests that the Pf-calpain subdomain IIa makes an active site, holding the catalytic triad residues in their appropriate orientation for catalysis. The mutation analysis further supports that those amino acid residues are functional and have enzymatic activity. Conclusion The identified active form of Pf-calpain could be utilized to establish high-throughput screening system for Pf-calpain inhibitors. Due to its unique monomeric structural property, Pf-calpain could be served as a novel anti-malarial drug target, which has a high specificity for malaria parasite

  2. French days on stable isotopes

    International Nuclear Information System (INIS)

    2000-01-01

    These first French days on stable isotopes took place in parallel with the 1. French days of environmental chemistry. Both conferences had common plenary sessions. The conference covers all aspects of the use of stable isotopes in the following domains: medicine, biology, environment, tracer techniques, agronomy, food industry, geology, petroleum geochemistry, cosmo-geochemistry, archaeology, bio-geochemistry, hydrology, climatology, nuclear and particle physics, astrophysics, isotope separations etc.. Abstracts available on CD-Rom only. (J.S.)

  3. French lessons in nuclear power

    International Nuclear Information System (INIS)

    Valenti, M.

    1991-01-01

    In stark contrast to the American atomic power experience is that of the French. Even the disaster at Chernobyl in 1986, which chilled nuclear programs throughout Western Europe, did not slow the pace of the nuclear program of the state-owned Electricite de France (EDF), based in Paris. Another five units are under construction and are scheduled to be connected to the French national power grid before the end of 1993. In 1989, the EDF's 58 nuclear reactors supplied 73 percent of French electrical needs, a higher percentage than any other country. In the United States, for example, only about 18 percent of electrical power is derived from the atom. Underpinning the success of nuclear energy in France is its use of standardized plant design and technology. This has been an imperative for the French nuclear power industry since 1974, when an intensive program of nuclear power plant construction began. It was then, in the aftermath of the first oil embargo, that the French government decided to reduce its dependence on imported oil by substituting atomic power sources for hydrocarbons. Other pillars supporting French nuclear success include retrofitting older plants with technological or design advances, intensive training of personnel, using robotic and computer aids to reduce downtime, controlling the entire nuclear fuel cycle, and maintaining a comprehensive public information effort about the nuclear program

  4. Anglicism in the French language

    Directory of Open Access Journals (Sweden)

    Firoozeh Asghari

    2014-09-01

    Full Text Available There is no question nowadays as to the international and powerful status of English at a global scale and, consequently, as to its presence in non-English speaking countries at different levels.  It is the languages which have mostly influenced French after the Two World War. So that now Anglicism exists in all levels of French. In this paper, besides the phenomenon of Anglicism, we will mainly focus on the reasons of increasing French interest in using of this phenomenon and also on the reactions taken against it in France. The method used in this research is descriptive – analytical.   The Result of this study shows that there is no purely linguistic reason for “Anglicism” in a country like France. In fact this paper remarks that the strong impact of English on French rather than being influenced by linguistic reasons is influenced by the cultural & social reasons. Additionally, the finding shows that the French especially the youth like using English for several reasons which include “prestige”, “snobbery” and “superiority”. Amongst the mentioned reasons in this paper, what caused the French to worry about the spread of Anglicism is due to fear of the American cultural influence, what is changing in the American cultural hegemony.

  5. Bridge joint fabrication and validation for SST-1 PF coil winding pack

    International Nuclear Information System (INIS)

    Prasad, Upendra; Sharma, A.N.; Patel, D.; Doshi, K.; Varmora, P.; Khristi, Y.; Pradhan, S.

    2014-01-01

    Highlights: • Prototype of bridge type joints fabricated and validated successfully. • Bridge type joints fabricated and validated on one of the SST-1 PF#3T coil successfully. • Joint resistance was measured with precision nano volt meter and PXI based data acquisition system. • Leak tightness of joint box was better than 3 × 10 −6 Pa m 3 s −1 . • The measured joint resistance of bridge type joint was ∼1.6 nano ohm. - Abstract: A novel concept of bridge joint for Poloidal field (PF) magnet of SST-1 with damaged winding pack has been realized. This joint has been fabricated on 5th and 6th layers of PF#3T coil winding pack (WP) after validation at 10 kA at liquid helium temperature of 4.2 K in current lead test chamber. The joint resistance of bridge joint was measured ∼1.6 nΩ at flat top DC current of 10 kA. This type of joint could be economically useful for revival of a shorted and damaged WP superconducting PF magnets of Tokamaks. In this paper, details of bridge joint design, fabrication and validations are discussed

  6. Hall effect in the normal phase of the organic superconductor (TMTSF)2PF6

    DEFF Research Database (Denmark)

    Moser, J.; Cooper, J.R.; Jerome, D.

    2000-01-01

    We report accurate Hall effect measurements performed in the normal phase of the quasi-one-dimensional organic conductor (TMTSF)(2)PF(6) at ambient pressure. The Hall coefficient is found to be strongly temperature dependent all the way from 300 K down to the spin density wave onset arising aroun...

  7. Dimensionality Crossover in the Organic Superconductor Tetramethyltetraselenafulvalene Hexafluorophosphate [(TMTSF)2PF6

    DEFF Research Database (Denmark)

    Jacobsen, Claus Schelde; Tanner, D. B.; Bechgaard, K.

    1981-01-01

    Polarized reflectance measurements from the far infrared to the visible are reported for (TMTSF)2PF6. At low temperatures, both parallel and perpendicular polarizations show plasma edges in the infrared with metallic reflection below these edges, indicating two- or three-dimensional behavior. The...

  8. Fridel-Crafts acylation using bismuth triflate in [BMI][PF6

    DEFF Research Database (Denmark)

    Tran, Phuong Hoang; Duus, Fritz; Le, Thach Ngoc

    2012-01-01

    Bismuth trifluoromethanesulfonate was found to be a good catalyst for the Friedel–Craftsacylation. Bismuthtriflate immobilized in an ionic liquid was the most efficient catalytic system. Bismuthtriflate in [BMI][PF6] catalyzes this reaction under microwave irradiation allowing the rapid synthesis...

  9. Impacts of P-f & Q-V Droop Control on MicroGrids Transient Stability

    Science.gov (United States)

    Zhao-xia, Xiao; Hong-wei, Fang

    Impacts of P-f & Q-V droop control on MicroGrid transient stability was investigated with a wind unit of asynchronous generator in the MicroGrid. The system frequency stability was explored when the motor load starts and its load power changes, and faults of different types and different locations occurs. The simulations were done by PSCAD/EMTDC.

  10. Design of coolant distribution system (CDS) for ITER PF AC/DC converter

    Energy Technology Data Exchange (ETDEWEB)

    Guo, Bin [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Song, Zhiquan, E-mail: zhquansong@ipp.ac.cn [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Fu, Peng; Xu, Xuesong; Li, Chuan [Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031 (China); Wang, Min; Dong, Lin [China International Nuclear Fusion Energy Program Execution Center, Beijing 100862 (China)

    2016-10-15

    Highlights: • System process and arrangement has been proposed to meet the multiple requirements from the converter system. • Thermal hydraulic analysis model has been developed to size and predict the system operation behavior. • Prototype test has been performed to validate the proposed design methodology. - Abstract: The Poloidal Field (PF) converter unit, playing an essential role in the plasma shape and position control in vertical and horizontal direction, which is an important part of ITER power supply system. As an important subsystem of the converter unit, the coolant distribution system has the function to distribute the cooling water from ITER component cooling water system (CCWS) to its main components at the required flow rate, pressure and temperature. This paper presents the thermal hydraulic design of coolant distribution system for the ITER PF converter unit. Different operational requirements of the PF converter unit regarding flow rate, temperature and pressure have been analyzed to design the system process and arrangement. A thermal-hydraulic analysis model has been built to size the system and predict the flow rate and temperature distribution of the system under the normal operation. Based on the system thermal-hydraulic analysis results, the system pressure profile has been plotted to evaluate the pressure behavior along each client flow path. A CDS prototype for the ITER PF converter has been constructed and some experiments have been performed on it. A good agreement of the flow distribution and temperature behavior between the simulated and test results validate the proposed design methodology.

  11. Beam transport of PF (Positron Factory) 2.5-GeV linac

    International Nuclear Information System (INIS)

    Shiraga, Takahiro; Asami, Akira; Suwada, Tsuyoshi; Kobayashi, Hitoshi.

    1993-01-01

    The beam transport is one of the most important problems in the linac to be used as the injector for the B-FACTORY accelerators. A basic problem of the beam transport is how to correct transport parameters immediately when a klystron becomes off. This is studied with the PF (Positron Factory) 2.5-GeV linac. (author)

  12. NbTi Strands Verification for ITER PF CICC Process Qualification of CNDA

    Science.gov (United States)

    Liu, F.; Liu, H.; Liu, S.; Liu, B.; Lei, L.; Wu, Y.

    2014-05-01

    China is in charge of most of Poloidal Field (PF) conductors production for the International Thermonuclear Experimental Reactor (ITER). The execution for PF conductors shall be in three main phases. According to ITER Procurement Arrangement (PA), the Domestic Agency (DA) shall be required to verify the room and low temperature acceptance tests carried out by the strand suppliers. As the reference laboratory of Chinese DA (CNDA), the superconducting strands test laboratory of Institute of Plasma Physics, Chinese Academy of Sciences (ASIPP) was undertaking the task of strands verification for ITER conductors. The verification test includes: diameter, Nickel plating thickness, copper-to-non-copper volume ratio, twist pitch direction and length, standard critical current (IC) and resistive transition index (n), residual resistance ration (RRR), and hysteresis loss. 48 NbTi strands with 7 billets were supplied for the PF Cable-In-Conduit Conductor (CICC) process qualification. In total, 54 samples were measured. The verification level for PF CICC process qualification was 100%. The test method, facility and results of each item are described in detail in this publication.

  13. Performance of CareStart™ Malaria Pf/Pv Combo test for the ...

    African Journals Online (AJOL)

    Background: CareStart™ Malaria Pf/Pv Combo test has shown encouraging results for the diagnosis of P. falciparum and P. vivax infections in Ethiopia. Nevertheless, the performance of the test could be affected by different factors like gene polymorphisms, excess heat and humidity. Hence, evaluation of the performance of ...

  14. Characterization of the integrated filamentous phage Pf5 and its involvement in small-colony formation

    NARCIS (Netherlands)

    Mooij, Marlies J.; Drenkard, Eliana; Llamas, María A.; Vandenbroucke-Grauls, Christina M. J. E.; Savelkoul, Paul H. M.; Ausubel, Frederick M.; Bitter, Wilbert

    2007-01-01

    Bacteriophages play an important role in bacterial virulence and phenotypic variation. It has been shown that filamentous bacteriophage Pf4 of Pseudomonas aeruginosa strain PAO1 mediates the formation of small-colony variants (SCVs) in biofilms. This morphology type is associated with parameters of

  15. Multiscale Simulations of Lamellar PS–PEO Block Copolymers Doped with LiPF6 Ions

    KAUST Repository

    Sethuraman, Vaidyanathan; Mogurampelly, Santosh; Ganesan, Venkat

    2017-01-01

    We report the results of atomistic simulations of the structural equilibrium properties of PS–PEO block copolymer (BCP) melt in the ordered lamellar phase doped with LiPF6 salt. A hybrid simulation strategy, consisting of steps of coarse

  16. Iron is a substrate of the Plasmodium falciparum chloroquine resistance transporter PfCRT in Xenopus oocytes.

    Science.gov (United States)

    Bakouh, Naziha; Bellanca, Sebastiano; Nyboer, Britta; Moliner Cubel, Sonia; Karim, Zoubida; Sanchez, Cecilia P; Stein, Wilfred D; Planelles, Gabrielle; Lanzer, Michael

    2017-09-29

    The chloroquine resistance transporter of the human malaria parasite Plasmodium falciparum , PfCRT, is an important determinant of resistance to several quinoline and quinoline-like antimalarial drugs. PfCRT also plays an essential role in the physiology of the parasite during development inside erythrocytes. However, the function of this transporter besides its role in drug resistance is still unclear. Using electrophysiological and flux experiments conducted on PfCRT-expressing Xenopus laevis oocytes, we show here that both wild-type PfCRT and a PfCRT variant associated with chloroquine resistance transport both ferrous and ferric iron, albeit with different kinetics. In particular, we found that the ability to transport ferrous iron is reduced by the specific polymorphisms acquired by the PfCRT variant as a result of chloroquine selection. We further show that iron and chloroquine transport via PfCRT is electrogenic. If these findings in the Xenopus model extend to P. falciparum in vivo , our data suggest that PfCRT might play a role in iron homeostasis, which is essential for the parasite's development in erythrocytes. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  17. ION-EXCHANGE IMMUNOAFFINITY PURIFICATION OF A RECOMBINANT BACULOVIRUS PLASMODIUM-FALCIPARUM APICAL MEMBRANE ANTIGEN, PF83/AMA-1

    NARCIS (Netherlands)

    NARUM, DL; WELLING, GW; THOMAS, AW

    1993-01-01

    A two-step purification regime has been developed for a quantitatively minor, putatively transmembrane, M(r) 83 000, apical membrane blood stage vaccine candidate antigen of Plasmodium falciparum (PF83/AMA-1), that has been expressed as a full-length baculovirus recombinant protein, PF83-FG8-1. The

  18. Roles of Rhizoxin and 2,4-diacetylphloroglucinol in Suppression of Fusarium spp. by the Rhizobacterium Pseudomonas fluorescens Pf-5

    Science.gov (United States)

    Pseudomonas fluorescens strain Pf-5 is a rhizosphere bacterium that acts as a biocontrol agent of soilborne plant diseases and produces at least 10 different secondary metabolites, including several with antifungal properties. We derived site-directed mutants of Pf-5 with single and multiple mutatio...

  19. 49 CFR 178.358 - Specification 21PF fire and shock resistant, phenolic-foam insulated, metal overpack.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Specification 21PF fire and shock resistant, phenolic-foam insulated, metal overpack. 178.358 Section 178.358 Transportation Other Regulations Relating... Class 7 (Radioactive) Materials § 178.358 Specification 21PF fire and shock resistant, phenolic-foam...

  20. Parasites causing cerebral falciparum malaria bind multiple endothelial receptors and express EPCR and ICAM-1-binding PfEMP1

    DEFF Research Database (Denmark)

    Tuikue Ndam, Nicaise; Moussiliou, Azizath; Lavstsen, Thomas

    2017-01-01

    Background: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) mediates the binding and accumulation of infected erythrocytes (IE) to blood vessels and tissues. Specific interactions have been described between PfEMP1 and human endothelial proteins CD36, intercellular adhesion molecule-1...

  1. Structure-Activity Relationships of the Human Immunodeficiency Virus Type 1 Maturation Inhibitor PF-46396.

    Science.gov (United States)

    Murgatroyd, Christopher; Pirrie, Lisa; Tran, Fanny; Smith, Terry K; Westwood, Nicholas J; Adamson, Catherine S

    2016-09-15

    HIV-1 maturation inhibitors are a novel class of antiretroviral compounds that consist of two structurally distinct chemical classes: betulinic acid derivatives and the pyridone-based compound PF-46396. It is currently believed that both classes act by similar modes of action to generate aberrant noninfectious particles via inhibition of CA-SP1 cleavage during Gag proteolytic processing. In this study, we utilized a series of novel analogues with decreasing similarity to PF-46396 to determine the chemical groups within PF-46396 that contribute to antiviral activity, Gag binding, and the relationship between these essential properties. A spectrum of antiviral activity (active, intermediate, and inactive) was observed across the analogue series with respect to CA-SP1 cleavage and HIV-1 (NL4-3) replication kinetics in Jurkat T cells. We demonstrate that selected inactive analogues are incorporated into wild-type (WT) immature particles and that one inactive analogue is capable of interfering with PF-46396 inhibition of CA-SP1 cleavage. Mutations that confer PF-46396 resistance can impose a defective phenotype on HIV-1 that can be rescued in a compound-dependent manner. Some inactive analogues retained the capacity to rescue PF-46396-dependent mutants (SP1-A3V, SP1-A3T, and CA-P157S), implying that they can also interact with mutant Gag. The structure-activity relationships observed in this study demonstrate that (i) the tert-butyl group is essential for antiviral activity but is not an absolute requirement for Gag binding, (ii) the trifluoromethyl group is optimal but not essential for antiviral activity, and (iii) the 2-aminoindan group is important for antiviral activity and Gag binding but is not essential, as its replacement is tolerated. Combinations of antiretroviral drugs successfully treat HIV/AIDS patients; however, drug resistance problems make the development of new mechanistic drug classes an ongoing priority. HIV-1 maturation inhibitors are novel as they

  2. The comparability of the constructs of the 16PF in the South African context

    Directory of Open Access Journals (Sweden)

    F. Abrahams

    1999-06-01

    Full Text Available The primary aims of the study were to determine whether the scores of the 16PF (SA92 are comparable in a crosscultural setting in South Africa, and also to investigate the influence of the gender of the research participants on the scores of the 16PF (SA92. The sample consisted of 983 students who were enrolled at different universities at the time of the field work. The statistical methods involved the application of descriptive statistics as well as methods to determine the comparability of the constructs. The results showed that although race exercised a considerable influence on the findings, this was not necessarily the case as far as gender was concerned. The presence of problems relating to the construct comparability of the test were also identified, as significant differences in means were found between the different race groups. Some of the implications of persisting with the use of the 16PF (SA92 in the South African context are outlined against the background of recently promulgated labour legislation. Opsomming Die primere doelstellings met die onderhawige studie was om die toepaslikheid van die 16PF (SA92 in Suid Afrikaanse konteks met sy diversiteit van kultuurgroepe te evalueer. Die invloed van die geslag van die navorsingsdeelnembers op die resultate is ook nagevors. Die deelnemergroep het bestaan uit 983 studente wat ten tye van die veldwerk aan verskillende universiteite gestudeer het. Benewens normale beskrywende statistiek, is daar ook gebruik gemaak van metodes om konstrukvergelykbaarheid te evalueer. Die bevindings het daarop gedui dat alhoewel ras 'n belangrike invloede op die toetsfaktore uitoefen, dit nie die geval is in soverre dit geslag betref nie. Die teenwoordigheid van probleme het ook ten opsigte van konstrukvergelykbaarheid na vore getree, aangesien betekenis voile verskille tussen gemiddeldes gevind is. Sommige van die implikasies van die volgehoue gebruik van die 16PF (SA92 in Suid Afrika word ook in die lig

  3. An infrared and Raman study of the reorientational motions and phase transition in and structure of CsPF6

    Science.gov (United States)

    Heyns, Anton M.; de Waal, Danita

    1992-12-01

    CsPF6I is face-centered cubic and the PF6- ions are randomly distributed among the six equivalent orientations in the crystal. The ions librate in equilibrium positions for an average time τ, and also jump from one orientation to another in a time which is much shorter than τ. The six different orientations in CsPF6I are of much lower symmetry than the full molecular one. The full vibrational spectra of CsPF6 are reported over the temperature range of 300-4 K and can be analyzed in Phase I in terms of (Oh,C¯4v) where C¯4v denotes the symmetry of the ion and Oh that of the site symmetry S. The polarized Raman spectra of single crystals of CsPF6I are interpreted in terms of all the different orientations of the PF6- ions and excellent agreement is obtained between predicted and experimental results. At 90 K CsPF6 undergoes a phase transition and a crystal structure of P4/nmm-D4h7 is assigned to Phase II. This transition is of the second order and shows behavior which corresponds to those of critical phenomena. An order parameter ξ is defined and a critical constant β is calculated to be equal to 0.3. In CsPF6II two orientations of the PF6- ions exist, both conforming to 4mm-C4v symmetry and the disorder persisting in this phase causes the splitting of the vibrational bands to be fully resolved below 60 K only. An activation energy of ˜3.0 kJ/mol is calculated for the motions of the PF6- ions between 90 and 60 K from the variation of the linewidths and intensities of vibrational bands.

  4. Autotaxin inhibition with PF8380 enhances the radiosensitivity of human and murine glioblastoma cell lines

    Directory of Open Access Journals (Sweden)

    Sandeep R Bhave

    2013-09-01

    Full Text Available Purpose: Glioblastoma multiforme (GBM is an aggressive primary brain tumor that is radio-resistant and recurs despite aggressive surgery, chemo and radiotherapy. Autotaxin (ATX is over expressed in various cancers including GBM and is implicated in tumor progression, invasion, and angiogenesis. Using the ATX specific inhibitor, PF-8380, we studied ATX as a potential target to enhance radiosensitivity in GBM.Methods and Materials: Mouse GL-261 and Human U87MG cells were used as GBM cell models. Clonogenic survival assays and tumor transwell invasion assays were performed using PF-8380 to evaluate role of ATX in survival and invasion. Radiation dependent activation of Akt was analyzed by immunoblotting. Tumor induced angiogenesis was studied using the dorsal skin-fold model in Gl-261. Heterotopic mouse GL-261 tumors were used to evaluate the efficacy of PF-8380 as a radiosensitizer.Results: Pretreatment of GL-261 and U87-MG cells with 1µM PF-8380 followed by 4Gy irradiation resulted in decreased clonogenic survival, decreased migration (33% in GL-261;P = 0.002 and 17.9% in U87; P = 0.012 decreased invasion (35.6% in GL-261; P = 0.0037 and 31.8% in U87; P = 0.002, and attenuated radiation induced Akt phosphorylation. In the tumor window model inhibition of ATX abrogated radiation-induced tumor neovascularization (65%; P=0.011. In a heterotopic mouse GL-261 tumors untreated mice took 11.2 days to reach a tumor volume of 7000 mm3 , however combination of PF-8380 (10mg/kg with irradiation (5 fractions of 2Gy took more than 32 days to reach a tumor volume of 7000 mm3 .Conclusion: Inhibition of ATX by PF8380 led to decreased invasion and enhanced radiosensitization of glioma cells. Radiation induced activation of Akt was abrogated by inhibition of ATX. Furthermore, inhibition of ATX led to diminished tumor vascularity and delayed tumor growth. These results suggest that inhibition of ATX may ameliorate glioblastoma response to radiotherapy.

  5. The French electricity report 2009

    International Nuclear Information System (INIS)

    2010-01-01

    RTE is the company responsible for running the French electricity transmission system. It is a public service operator, tasked with operating, maintaining and developing the high and extra high voltage network. It guarantees the reliability and proper operation of the power network. These missions were entrusted to it by the Law of 10 February 2000. With 100,000 km of lines between 63,000 and 400,000 volts and 45 cross-border lines, the network operated by RTE is the biggest in Europe. In 2008, RTE posted turnover of euros 4,221 m and currently employs around 8,500 staff. RTE, by virtue of the missions entrusted to it by the Law of 10 February 2000, is the central player in the French power system. For the purpose of maintaining the real time balance between supply and demand, and managing contractual relations with customers connected to its network, RTE monitors all the electrical energy that enters and leaves the public transmission system. Through its management of the 45 interconnection lines linking France with its neighbours, RTE also tracks all import and export data, on behalf of players in the French and European electricity market. RTE constantly records and examines data provided by all market players. Using the data, monthly and annually, it publishes exhaustive figures for the French power system (demand, generation, imports and exports), which offer the only truly accurate reflection of the real state of the sector's economy. This report presents these figures for the year 2009. Contents: 1 - French electricity demand down by 1.6% on 2008; 2 - A drop in French electricity generation; 3 - The balance of cross-border exchanges falls, but remains positive; 4 - RTE continues to invest in a robust network capable of keeping up with developments in the electricity industry; 5 - Appendix 1: New infrastructures on the RTE network in 2009; 6 - Appendix 2: Electricity quality; 7 - Appendix 3: Mature market mechanisms

  6. Dissection of the role of PfEMP1 and ICAM-1 in the sensing of Plasmodium-falciparum-infected erythrocytes by natural killer cells.

    Directory of Open Access Journals (Sweden)

    Myriam Baratin

    Full Text Available BACKGROUND: Host innate immunity contributes to malaria clinical outcome by providing protective inflammatory cytokines such as interferon-gamma, and by shaping the adaptive immune response. Plasmodium falciparum (Pf is the etiologic agent of the most severe forms of human malaria. Natural Killer (NK cells are lymphocytes of the innate immune system that are the first effectors to produce interferon-gamma in response to Pf. However, the molecular bases of Pf-NK cell recognition events are unknown. Our study focuses on the role of Pf erythrocyte membrane protein 1 (PfEMP1, a major Pf virulence factor. PfEMP1 is expressed on parasitized-erythrocytes and participates to vascular obstruction through the binding to several host receptors. PfEMP1 is also a pivotal target for host antibody response to Pf infection. METHODOLOGY/PRINCIPAL FINDINGS: Using genetically-engineered parasite mutant strains, a human genetic deficiency, and blocking antibodies, we identified two receptor-ligand pairs involved in two uncoupled events occurring during the sensing of Pf infection by NK cells. First, PfEMP1 interaction with one of its host receptor, chondroitin sulfate A, mediates the cytoadhesion of Pf-infected erythrocytes to human NK cell lines, but is not required for primary NK cell activation. Second, intercellular adhesion molecule-1 (ICAM-1, another host receptor for PfEMP1, is mandatory for NK cell interferon-gamma response. In this case, ICAM-1 acts via its engagement with its host ligand, LFA-1, and not with PfEMP1, consistent with the obligatory cross-talk of NK cells with macrophages for their production of interferon-gamma. CONCLUSION/SIGNIFICANCE: PfEMP1-independent but ICAM-1/LFA-1-dependent events occurring during NK cell activation by Pf highlight the fundamental role of cellular cooperation during innate immune response to malaria.

  7. General and Professional French Courses

    CERN Document Server

    2007-01-01

    These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://cern.ch/Training or contact Nathalie Dumeaux, tel. 78144. Writing Professional Documents in French The next session will take place from 8 October to 14 December 2007. This course is designed for people with a good level of spoken French. Duration: 30 hours (3 hours a week) Price: 660 CHF (for a minimum of 8 students). For registration and further information, please consult our Web pages: http://cern.ch/Training or contact Nathalie Dumeaux, tel. 78144.

  8. French regulation and waste management

    International Nuclear Information System (INIS)

    1984-08-01

    The organization and the role played by French safety authorities for waste management are described. The French policy for storage and conditioning: basic objectives and waste management optimization are specified. Safety requirements are based on the barrier principle, they are mentioned for packaging and storage. The ''Institut de Protection et Surete Nucleaire'' deals not only with safety analysis but also help the ''autorites ministerielles'' for the development of fundamental safety rules. Examples for spent fuel storage and radioactive materials transport are treated in appendixes [fr

  9. Suppressive Effects of the Site 1 Protease (S1P Inhibitor, PF-429242, on Dengue Virus Propagation

    Directory of Open Access Journals (Sweden)

    Leo Uchida

    2016-02-01

    Full Text Available Dengue virus (DENV infection causes one of the most widespread mosquito-borne diseases in the world. Despite the great need, effective vaccines and practical antiviral therapies are still under development. Intracellular lipid levels are regulated by sterol regulatory elements-binding proteins (SREBPs, which are activated by serine protease, site 1 protease (S1P. Small compound PF-429242 is known as a S1P inhibitor and the antivirus effects have been reported in some viruses. In this study, we examined the anti-DENV effects of PF-429242 using all four serotypes of DENV by several primate-derived cell lines. Moreover, emergence of drug-resistant DENV mutants was assessed by sequential passages with the drug. DENV dependency on intracellular lipids during their infection was also evaluated by adding extracellular lipids. The addition of PF-429242 showed suppression of viral propagation in all DENV serotypes. We showed that drug-resistant DENV mutants are unlikely to emerge after five times sequential passages through treatment with PF-429242. Although the levels of intracellular cholesterol and lipid droplets were reduced by PF-429242, viral propagations were not recovered by addition of exogenous cholesterol or fatty acids, indicating that the reduction of LD and cholesterol caused by PF-429242 treatment is not related to its mechanism of action against DENV propagation. Our results suggest that PF-429242 is a promising candidate for an anti-DENV agent.

  10. A homeodomain transcription factor gene, PfMSX, activates expression of Pif gene in the pearl oyster Pinctada fucata.

    Directory of Open Access Journals (Sweden)

    Mi Zhao

    Full Text Available We reported pearl oyster Pinctada fucata cDNA and genomic characterization of a new homeobox-containing protein, PfMSX. The PfMSX gene encodes a transcription factor that was localized to the nucleus. Analyses of PfMSX mRNA in tissues and developmental stages showed high expressions in mantle or D-shaped larvae. In electrophoretic mobility shift assays (EMSAs PfMSX binded to MSX consensus binding sites in the 5' flanking region of the Pif promoter. In co-transfection experiment PfMSX transactivated reporter constructs containing Pif promoter sequences, and mutation of the MSX-binding sites attenuated transactivation. A knockdown experiment using PfMSX dsRNA showed decreased Pif mRNA and unregular crystallization of the nacreous layer using scanning electron microscopy. Our results suggested that PfMSX was a conserved homeodomain transcription factor gene, which can activate Pif gene expression through MSX binding site, and was then involved in the mineralization process in pearl oyster Pinctada fucata. Our data provided important clues about mechanisms regulating biomineralization in pearl oyster.

  11. A Homeodomain Transcription Factor Gene, PfMSX, Activates Expression of Pif Gene in the Pearl Oyster Pinctada fucata

    Science.gov (United States)

    Zhao, Mi; He, Maoxian; Huang, Xiande; Wang, Qi

    2014-01-01

    We reported pearl oyster Pinctada fucata cDNA and genomic characterization of a new homeobox-containing protein, PfMSX. The PfMSX gene encodes a transcription factor that was localized to the nucleus. Analyses of PfMSX mRNA in tissues and developmental stages showed high expressions in mantle or D-shaped larvae. In electrophoretic mobility shift assays (EMSAs) PfMSX binded to MSX consensus binding sites in the 5′ flanking region of the Pif promoter. In co-transfection experiment PfMSX transactivated reporter constructs containing Pif promoter sequences, and mutation of the MSX-binding sites attenuated transactivation. A knockdown experiment using PfMSX dsRNA showed decreased Pif mRNA and unregular crystallization of the nacreous layer using scanning electron microscopy. Our results suggested that PfMSX was a conserved homeodomain transcription factor gene, which can activate Pif gene expression through MSX binding site, and was then involved in the mineralization process in pearl oyster Pinctada fucata. Our data provided important clues about mechanisms regulating biomineralization in pearl oyster. PMID:25099698

  12. A homeodomain transcription factor gene, PfMSX, activates expression of Pif gene in the pearl oyster Pinctada fucata.

    Science.gov (United States)

    Zhao, Mi; He, Maoxian; Huang, Xiande; Wang, Qi

    2014-01-01

    We reported pearl oyster Pinctada fucata cDNA and genomic characterization of a new homeobox-containing protein, PfMSX. The PfMSX gene encodes a transcription factor that was localized to the nucleus. Analyses of PfMSX mRNA in tissues and developmental stages showed high expressions in mantle or D-shaped larvae. In electrophoretic mobility shift assays (EMSAs) PfMSX binded to MSX consensus binding sites in the 5' flanking region of the Pif promoter. In co-transfection experiment PfMSX transactivated reporter constructs containing Pif promoter sequences, and mutation of the MSX-binding sites attenuated transactivation. A knockdown experiment using PfMSX dsRNA showed decreased Pif mRNA and unregular crystallization of the nacreous layer using scanning electron microscopy. Our results suggested that PfMSX was a conserved homeodomain transcription factor gene, which can activate Pif gene expression through MSX binding site, and was then involved in the mineralization process in pearl oyster Pinctada fucata. Our data provided important clues about mechanisms regulating biomineralization in pearl oyster.

  13. A Novel Acidic Matrix Protein, PfN44, Stabilizes Magnesium Calcite to Inhibit the Crystallization of Aragonite*

    Science.gov (United States)

    Pan, Cong; Fang, Dong; Xu, Guangrui; Liang, Jian; Zhang, Guiyou; Wang, Hongzhong; Xie, Liping; Zhang, Rongqing

    2014-01-01

    Magnesium is widely used to control calcium carbonate deposition in the shell of pearl oysters. Matrix proteins in the shell are responsible for nucleation and growth of calcium carbonate crystals. However, there is no direct evidence supporting a connection between matrix proteins and magnesium. Here, we identified a novel acidic matrix protein named PfN44 that affected aragonite formation in the shell of the pearl oyster Pinctada fucata. Using immunogold labeling assays, we found PfN44 in both the nacreous and prismatic layers. In shell repair, PfN44 was repressed, whereas other matrix proteins were up-regulated. Disturbing the function of PfN44 by RNAi led to the deposition of porous nacreous tablets with overgrowth of crystals in the nacreous layer. By in vitro circular dichroism spectra and fluorescence quenching, we found that PfN44 bound to both calcium and magnesium with a stronger affinity for magnesium. During in vitro calcium carbonate crystallization and calcification of amorphous calcium carbonate, PfN44 regulated the magnesium content of crystalline carbonate polymorphs and stabilized magnesium calcite to inhibit aragonite deposition. Taken together, our results suggested that by stabilizing magnesium calcite to inhibit aragonite deposition, PfN44 participated in P. fucata shell formation. These observations extend our understanding of the connections between matrix proteins and magnesium. PMID:24302723

  14. Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation.

    Science.gov (United States)

    Uchida, Leo; Urata, Shuzo; Ulanday, Gianne Eduard L; Takamatsu, Yuki; Yasuda, Jiro; Morita, Kouichi; Hayasaka, Daisuke

    2016-02-10

    Dengue virus (DENV) infection causes one of the most widespread mosquito-borne diseases in the world. Despite the great need, effective vaccines and practical antiviral therapies are still under development. Intracellular lipid levels are regulated by sterol regulatory elements-binding proteins (SREBPs), which are activated by serine protease, site 1 protease (S1P). Small compound PF-429242 is known as a S1P inhibitor and the antivirus effects have been reported in some viruses. In this study, we examined the anti-DENV effects of PF-429242 using all four serotypes of DENV by several primate-derived cell lines. Moreover, emergence of drug-resistant DENV mutants was assessed by sequential passages with the drug. DENV dependency on intracellular lipids during their infection was also evaluated by adding extracellular lipids. The addition of PF-429242 showed suppression of viral propagation in all DENV serotypes. We showed that drug-resistant DENV mutants are unlikely to emerge after five times sequential passages through treatment with PF-429242. Although the levels of intracellular cholesterol and lipid droplets were reduced by PF-429242, viral propagations were not recovered by addition of exogenous cholesterol or fatty acids, indicating that the reduction of LD and cholesterol caused by PF-429242 treatment is not related to its mechanism of action against DENV propagation. Our results suggest that PF-429242 is a promising candidate for an anti-DENV agent.

  15. Chemical vapor deposition of NiSi using Ni(PF3)4 and Si3H8

    International Nuclear Information System (INIS)

    Ishikawa, M.; Muramoto, I.; Machida, H.; Imai, S.; Ogura, A.; Ohshita, Y.

    2007-01-01

    NiSi x films were deposited using chemical vapor deposition (CVD) with a Ni(PF 3 ) 4 and Si 3 H 8 /H 2 gas system. The step coverage quality of deposited NiSi x was investigated using a horizontal type of hot-wall low pressure CVD reactor, which maintained a constant temperature throughout the deposition area. The step coverage quality improved as a function of the position of the gas flow direction, where PF 3 gas from decomposition of Ni(PF 3 ) 4 increased. By injecting PF 3 gas into the Ni(PF 3 ) 4 and Si 3 H 8 /H 2 gas system, the step coverage quality markedly improved. This improvement in step coverage quality naturally occurred when PF 3 gas was present, indicating a strong relationship. The Si/Ni deposit ratio at 250 deg. C is larger than at 180 deg. C. It caused a decreasing relative deposition rate of Ni to Si. PF 3 molecules appear to be adsorbed on the surface of the deposited film and interfere with faster deposition of active Ni deposition species

  16. The Crystal Structure of PF-8, the DNA Polymerase Accessory Subunit from Kaposi's Sarcoma-Associated Herpesvirus

    Energy Technology Data Exchange (ETDEWEB)

    Baltz, Jennifer L.; Filman, David J.; Ciustea, Mihai; Silverman, Janice Elaine Y.; Lautenschlager, Catherine L.; Coen, Donald M.; Ricciardi, Robert P.; Hogle, James M.; (UPENN)

    2009-12-01

    Kaposi's sarcoma-associated herpesvirus is an emerging pathogen whose mechanism of replication is poorly understood. PF-8, the presumed processivity factor of Kaposi's sarcoma-associated herpesvirus DNA polymerase, acts in combination with the catalytic subunit, Pol-8, to synthesize viral DNA. We have solved the crystal structure of residues 1 to 304 of PF-8 at a resolution of 2.8 {angstrom}. This structure reveals that each monomer of PF-8 shares a fold common to processivity factors. Like human cytomegalovirus UL44, PF-8 forms a head-to-head dimer in the form of a C clamp, with its concave face containing a number of basic residues that are predicted to be important for DNA binding. However, there are several differences with related proteins, especially in loops that extend from each monomer into the center of the C clamp and in the loops that connect the two subdomains of each protein, which may be important for determining PF-8's mode of binding to DNA and to Pol-8. Using the crystal structures of PF-8, the herpes simplex virus catalytic subunit, and RB69 bacteriophage DNA polymerase in complex with DNA and initial experiments testing the effects of inhibition of PF-8-stimulated DNA synthesis by peptides derived from Pol-8, we suggest a model for how PF-8 might form a ternary complex with Pol-8 and DNA. The structure and the model suggest interesting similarities and differences in how PF-8 functions relative to structurally similar proteins.

  17. Evasion of immunity to Plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1

    DEFF Research Database (Denmark)

    Barfod, Lea; Dalgaard, Michael B; Pleman, Suzan T

    2011-01-01

    1 (PfEMP1) family is central to both. Here, we present evidence of a P. falciparum evasion mechanism not previously documented: the masking of PfEMP1-specific IgG epitopes by nonspecific IgM. Nonspecific IgM binding to erythrocytes infected by parasites expressing the PfEMP1 protein VAR2CSA...

  18. Characterization of polyacrylamide-stabilized Pf1 phage liquid crystals for protein NMR spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Trempe, Jean-Francois; Morin, Frederick G.; Xia Zhicheng; Marchessault, Robert H.; Gehring, Kalle [McGill University, Department of Biochemistry and Department of Chemistry (Canada)], E-mail: kalle@bri.nrc.ca

    2002-01-15

    A new polymer-stabilized nematic liquid crystal has been characterized for the measurement of biomolecular residual dipolar couplings. Filamentous Pf1 phage were embedded in a polyacrylamide matrix that fixes the orientation of the particles. The alignment was characterized by the quadrupolar splitting of the {sup 2}H NMR water signal and by the measurement of {sup 1}H-{sup 15}N residual dipolar couplings (RDC) in the archeal translation elongation factor 1{beta}. Protein dissolved in the polymer-stabilized medium orients quantitatively as in media without polyacrylamide. We show that the quadrupolar splitting and RDCs are zero in media in which the Pf1 phage particles are aligned at the magic angle. This allows measurement of J and dipolar couplings in a single sample.

  19. Characterization of polyacrylamide-stabilized Pf1 phage liquid crystals for protein NMR spectroscopy

    International Nuclear Information System (INIS)

    Trempe, Jean-Francois; Morin, Frederick G.; Xia Zhicheng; Marchessault, Robert H.; Gehring, Kalle

    2002-01-01

    A new polymer-stabilized nematic liquid crystal has been characterized for the measurement of biomolecular residual dipolar couplings. Filamentous Pf1 phage were embedded in a polyacrylamide matrix that fixes the orientation of the particles. The alignment was characterized by the quadrupolar splitting of the 2 H NMR water signal and by the measurement of 1 H- 15 N residual dipolar couplings (RDC) in the archeal translation elongation factor 1β. Protein dissolved in the polymer-stabilized medium orients quantitatively as in media without polyacrylamide. We show that the quadrupolar splitting and RDCs are zero in media in which the Pf1 phage particles are aligned at the magic angle. This allows measurement of J and dipolar couplings in a single sample

  20. Review of solution approach, methods, and recent results of the TRAC-PF1 system code

    International Nuclear Information System (INIS)

    Mahaffy, J.H.; Liles, D.R.; Knight, T.D.

    1983-01-01

    The current version of the Transient Reactor Analysis Code (TRAC-PF1) was created to improve on the capabilities of its predecessor (TRAC-PD2) for analyzing slow reactor transients such as small-break loss-of-coolant accidents. TRAC-PF1 continues to use a semi-implicit finite-difference method for modeling three-dimensional flows in the reactor vessel. However, it contains a new stability-enhancing two-step (SETS) finite-difference tecnique for one-dimensional flow calculations. This method is not restricted by a material Courant stability condition, allowing much larger time-step sizes during slow transients than would a semi-implicit method. These have been successfully applied to the analysis of a variety of experiments and hypothetical plant transients covering a full range of two-phase flow regimes

  1. [BMIM][PF(6)] promotes the synthesis of halohydrin esters from diols using potassium halides.

    Science.gov (United States)

    Oromí-Farrús, Mireia; Eras, Jordi; Villorbina, Gemma; Torres, Mercè; Llopis-Mestre, Veronica; Welton, Tom; Canela, Ramon

    2008-10-01

    Haloesterification of diverse diols with various carboxylic acids was achieved using potassium halides (KX) as the only halide source in ionic liquids. The best yield was obtained in [BMIM][PF(6)] when 1,2-octanediol, palmitic acid and KBr were used. This yield was 85% and the regioisomer with the bromine in primary position was present in a 75:25 ratio. The regioisomeric ratio could be improved using either KCl or some phenylcarboxylic acids. [BMIM][PF(6)] acts as both reaction media and catalyst of the reaction. To the best of our knowledge, this type of combined reaction using an ionic liquid is unprecedented. The other solvents tested did not lead either to the same yield or to the same regioisomeric ratio.

  2. Anisotropic p-f mixing mechanism explaining anomalous magnetic properties in Ce monopnictides

    International Nuclear Information System (INIS)

    Takahashi, H.; Kasuya, T.

    1985-01-01

    The indirect f-f-interaction derived from fourth-order perturbation theory with respect to the p-f mixing is calculated using the valence bands obtained by the APW band calculations. The type of the f-f-interactions is described as the coupling through the symmetry exchange under the cubic crystal field, which cannot be written as a simple bilinear type of 4f spin operator. It is necessary to consider the short-range-ordering effect as well as the non-linear effect of the p-f mixing to explain the fact that a type-I antiferromagnetic ordering is established by the second-order transition in CeBi. (author)

  3. Measurements of energy spectra of fast electrons from PF-1000 in the upstream and downstream directions

    Energy Technology Data Exchange (ETDEWEB)

    Kwiatkowski, R.; Czaus, K.; Skladnik-Sadowska, E.; Malinowski, K.; Zebrowski, J. [The Andrzej Soltan Institute for Nuclear Studies (IPJ), 05-400 Otwock-Swierk (Poland); Sadowski, M.J. [The Andrzej Soltan Institute for Nuclear Studies (IPJ), 05-400 Otwock-Swierk (Poland); Karpinski, L.; Paduch, M.; Scholz, M. [Institute of Plasma Physics and Laser Microfusion (IPPLM), 01-497 Warsaw (Poland); Kubes, P. [Czech Technical University (CVUT), 166-27 Prague, (Czech Republic)

    2011-07-01

    The paper describes measurements of energy spectra of electrons emitted in the upstream direction along the symmetry-axis of the PF-1000 facility, operated with the deuterium filling at 21 kV, 290 kJ. The measurements were performed with a magnetic analyzer. The same analyzer was used to measure also electron beams emitted in along the symmetry-axis in the downstream direction. The recorded spectra showed that the electron-beams emitted in the upstream direction have energies in the range from about 40 keV to about 800 keV, while those in the downstream direction have energies in the range from about 60 keV to about 200 keV. These spectra confirm that in the PF (Plasma Focus) plasma column there appear strong local fields accelerating charged particles in different directions. This document is composed of a paper and a poster. (authors)

  4. Synthesis of Ca(PF$_6$)$_2$, formed $\\textit{via}$ nitrosonium oxidation of calcium

    OpenAIRE

    Keyzer, Evan; Matthews, PD; Liu, Zigeng; Bond, Andrew David; Grey, Clare Philomena; Wright, Dominic Simon

    2017-01-01

    The development of rechargeable Ca-ion batteries as an alternative to Li systems has been limited by the availability of suitable electrolyte salts. We present the synthesis of complexes of Ca(PF$_6$)$_2$ (a key potential Ca battery electrolyte salt) $\\textit{via}$ the treatment of Ca metal with NOPF$_6$, and explore their conversion to species containing PO$_2$F$_2$$^{-}$ under the reaction conditions. NSERC of Canada PGSD; Gonville and Caius College; Cambridge Commonwealth, European, and...

  5. Synthesis of Ca(PF6)2, formed via nitrosonium oxidation of calcium.

    Science.gov (United States)

    Keyzer, Evan N; Matthews, Peter D; Liu, Zigeng; Bond, Andrew D; Grey, Clare P; Wright, Dominic S

    2017-04-20

    The development of rechargeable Ca-ion batteries as an alternative to Li systems has been limited by the availability of suitable electrolyte salts. We present the synthesis of complexes of Ca(PF 6 ) 2 (a key potential Ca battery electrolyte salt) via the treatment of Ca metal with NOPF 6 , and explore their conversion to species containing PO 2 F 2 - under the reaction conditions.

  6. Low temperature specific heat of the spin-density-wave compound (TMTSF)2PF6

    DEFF Research Database (Denmark)

    Odin, J.; Lasjaunias, J.C.; Biljakovic, K.

    1994-01-01

    We report on specific heat measurements of the SDW compound (TMTSF)2PF6 between 2 and 25 K, performed by two different techniques. We discuss the two successive transitions which occur in this T-range : the SDW ordering transition at T = 12.1 K, and a glass transition around-3-3.5 K. The latter i...... is very dependent on the kinetics of measurements, and has all characteristic features of freezing of supercooled liquids....

  7. Artificial intelligence and distance learning philosophy in support of PfP mandate

    OpenAIRE

    Antoliš, Krunoslav

    2003-01-01

    Computers have long been utilised in the legal environment. The main use of computers however, has merely been to automate office tasks. More exciting is the prospect of using artificial intelligence (AI) technology to create computers that can emulate the substantive legal jobs performed by lawyers, to create computers that can autonomously reason with the law to determine legal solutions, for example: structuring and support of Partnership for Peace (PfP) mandate. Such attempts have not bee...

  8. Fuel models and results from the TRAC-PF1/MIMAS TMI-2 accident calculation

    International Nuclear Information System (INIS)

    Schwegler, E.C.; Maudlin, P.J.

    1983-01-01

    A brief description of several fuel models used in the TRAC-PF1/MIMAS analysis of the TMI-2 accident is presented, and some of the significant fuel-rod behavior results from this analysis are given. Peak fuel-rod temperatures, oxidation heat production, and embrittlement and failure behavior calculated for the TMI-2 accident are discussed. Other aspects of fuel behavior, such as cladding ballooning and fuel-cladding eutectic formation, were found not to significantly affect the accident progression

  9. Influence of Nitrogen Source on 2,4-diacetylphloroglucinol Production by the Biocontrol Strain Pf-5

    OpenAIRE

    M, Hultberg; B, Alsanius

    2008-01-01

    The production of 2,4-diacetylphloroglucinol (DAPG) by the biocontrol agent Pseudomonas fluorescens Pf-5 was studied in nutrient-solution based media with varying nitrogen content. No production of DAPG was observed when organic nitrogen was omitted from the media, regardless of the inorganic nitrogen source used. Furthermore, a micromolar concentration range of organic nitrogen was insufficient to sustain production. When a millimolar concentration range of organic nitrogen was used, DAPG pr...

  10. TRAC-PF1 code assessment using OECD LOFT LP-FP-1 experiment

    International Nuclear Information System (INIS)

    Barbero, F.J.

    1992-04-01

    This report assesses thermal-hydraulic aspects of LOFT LP-FP-1 experiment making use of TRAC-PF1/MOD1. LP-FP-1 experiment studies the system thermal-hydraulic and core thermal response for initial and boundary conditions similar to a large-break design basis LOCA leading to fission product release from the fuel cladding gap region. It also assesses the fission product retention effectiveness of the PWR-ECCS in best estimate conditions

  11. Phebus PF, international major programme in nuclear safety: the last test

    International Nuclear Information System (INIS)

    2004-11-01

    For the last test Phebus P.F. (the fifth one), it is expected a fast degradation of the boron carbon pencils, leading to a fast release of boron and carbon gas species. Among the carbon gas produced, it is expected to a presence of methane susceptible to interact with iodine to form organic species. The conditions of tests should lead to observe a contribution of containment sump to volatile iodine generation. (N.C.)

  12. Design study on a high brilliance lattice of the PF storage ring

    International Nuclear Information System (INIS)

    Katoh, M.; Araki, A.; Kobayashi, Y.; Hori, Y.

    1994-01-01

    A high brilliance lattice of the PF storage ring is proposed. A small beam emittance of 27 nm-rad (about one fifth of the present value) can be achieved by doubling the number of the quadrupoles in the FODO cells. This emittance reduction will result in ten times brighter synchrotron light from the existing insertion devices. The problems incidental to the low emittance lattice, the small dynamic aperture and the short Touschek lifetime, will be discussed. (author)

  13. The french electric power evaluation 2005

    International Nuclear Information System (INIS)

    2006-01-01

    This document takes stock on the french electric power situation for the year 2005. It provides information on the consumption the trade, the production, the french market and the RTE (Electric power transport network) infrastructure. (A.L.B.)

  14. French how to speak and write it

    CERN Document Server

    Lemaître, Joseph

    1978-01-01

    Probably the most delightful, useful, and comprehensive elementary book available for learning spoken and written French, either with or without a teacher. Includes colloquial French conversations as well as grammar, vocabulary, and idiom studies.

  15. Directory of the French nuclear industry

    International Nuclear Information System (INIS)

    2002-10-01

    This directory includes data sheets on the French companies operating in the nuclear industry. It begins with an introduction containing information on the French nuclear industry: 1 - nuclear power development in France (national energy plan, history, organization, economic advantages, reactors); 2 - French operator: Electricite de France (EdF); 3 - the industry (Areva, Cogema, mining activities, uranium chemistry and enrichment, processing, recycling, engineering, services, Framatome ANP); 4 - R and D and knowledge dissemination: French atomic energy commission (CEA); 5 - nuclear safety, security, control and regulation: nuclear safety authority (ASN), general direction of nuclear safety and radioprotection (DGSNR), institute of radioprotection and nuclear safety (IRSN), radioactive wastes, ANDRA's role; 6 - associations: French atomic forum (FAF), French nuclear industry trade association (GIIN), French nuclear energy society (SFEN), French radiation protection society (SFRP). Then, the data sheets of the directory follows. (J.S.)

  16. Implementation of JAERI's reflood model into TRAC-PF1/MOD1 code

    International Nuclear Information System (INIS)

    Akimoto, Hajime; Ohnuki, Akira; Murao, Yoshio

    1993-02-01

    Selected physical models of REFLA code, that is a reflood analysis code developed at JAERI, were implemented into the TRAC-PF1/MOD1 code in order to improve the predictive capability of the TRAC-PF1/MOD1 code for the core thermal hydraulic behaviors during the reflood phase in a PWR LOCA. Through comparisons of physical models between both codes, (1) Murao-Iguchi void fraction correlation, (2) the drag coefficient correlation acting to drops, (3) the correlation for wall heat transfer coefficient in the film boiling regime, (4) the quench velocity correlation and (5) heat transfer correlations for the dispersed flow regime were selected from the REFLA code to be implemented into the TRAC-PF1/MOD1 code. A method for the transformation of the void fraction correlation to the equivalent interfacial friction model was developed and the effect of the transformation method on the stability of the solution was discussed. Through assessment calculation using data from CCTF (Cylindrical Core Test Facility) flat power test, it was confirmed that the predictive capability of the TRAC code for the core thermal hydraulic behaviors during the reflood can be improved by the implementation of selected physical models of the REFLA code. Several user guidelines for the modified TRAC code were proposed based on the sensitivity studies on fluid cell number in the hydraulic calculation and on node number and effect of axial heat conduction in the heat conduction calculation of fuel rod. (author)

  17. Assessment of TRAC-PF1/MOD1 code for large break LOCA in PWR

    International Nuclear Information System (INIS)

    Akimoto, Hajime; Ohnuki, Akira; Murao, Yoshio; Abe, Yutaka.

    1993-03-01

    As the first step of the REFLA/TRAC code development, the TRAC/PF1/MOD1 code has been assessed for various experiments that simulate postulated large-break loss-of-coolant accident (LBLOCA) in PWR to understand the predictive capability and to identify the problem areas of the code. The assessment calculations were performed for separate effect tests for critical flow, counter current flow, condensation at cold leg and reflood as well as integral tests to understand predictability for individual phenomena. This report summarizes results from the assessment calculations of the TRAC-PF1/MOD1 code for LBLOCA in PWR. The assessment calculations made clear the predictive capability and problem areas of the TRAC-PF1/MOD1 code for LBLOCA in PWR. The areas, listed below, should be improved for more realistic and effective simulation of LBLOCA in PWR: (1) core heat transfer model during blowdown, (2) ECC bypass model at downcomer during refill, (3) condensation model during accumulator injection, and (4) core thermal hydraulic model during reflood. (author) 57 refs

  18. Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL Confer Multidrug Resistance

    Directory of Open Access Journals (Sweden)

    Gregory LaMonte

    2016-07-01

    Full Text Available Mutations in the Plasmodium falciparum cyclic amine resistance locus (PfCARL are associated with parasite resistance to the imidazolopiperazines, a potent class of novel antimalarial compounds that display both prophylactic and transmission-blocking activity, in addition to activity against blood-stage parasites. Here, we show that pfcarl encodes a protein, with a predicted molecular weight of 153 kDa, that localizes to the cis-Golgi apparatus of the parasite in both asexual and sexual blood stages. Utilizing clustered regularly interspaced short palindromic repeat (CRISPR-mediated gene introduction of 5 variants (L830V, S1076N/I, V1103L, and I1139K, we demonstrate that mutations in pfcarl are sufficient to generate resistance against the imidazolopiperazines in both asexual and sexual blood-stage parasites. We further determined that the mutant PfCARL protein confers resistance to several structurally unrelated compounds. These data suggest that PfCARL modulates the levels of small-molecule inhibitors that affect Golgi-related processes, such as protein sorting or membrane trafficking, and is therefore an important mechanism of resistance in malaria parasites.

  19. Quantum Hall effect and anomalous transport in (TMTSF)2PF6

    International Nuclear Information System (INIS)

    Eom, J.; Cho, H.; Kang, W.; Chicago Univ., IL

    1999-01-01

    Under low temperatures and high magnetic fields, quasi-one dimensional organic conductor (TMTSFP) 2 PF 6 exhibits a series of transitions to field-induced spin density wave (FISDW). Slightly above the onset of superconductivity in (TMTSF) 2 PF 6 , we observe a series of intervening phases that interrupt the sequence of FISDW that gives rise to the quantum Hall effect. These phases can be identified either as negative quantum numbered FISDW states or a puzzling arboresecent phase. Detailed study of the QHE in (TMTSF) 2 PF 6 reveals that the transport in the FISDW phases is dominated by anomalous longitudinal resistivities ρ xx and ρ yy that remain finite at low temperatures. While the quantization of σ xy is not adversely affected at high magnetic fields, the transport in the intermediate magnetic field remains complicated. In addition, the conductivity along applied magnetic field, σ zz , cannot be easily understood in terms of three-dimensional QHE and is suggestive of the importance of inter-layer coupling. (orig.)

  20. QSAR study on the antimalarial activity of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors.

    Science.gov (United States)

    Hou, X; Chen, X; Zhang, M; Yan, A

    2016-01-01

    Plasmodium falciparum, the most fatal parasite that causes malaria, is responsible for over one million deaths per year. P. falciparum dihydroorotate dehydrogenase (PfDHODH) has been validated as a promising drug development target for antimalarial therapy since it catalyzes the rate-limiting step for DNA and RNA biosynthesis. In this study, we investigated the quantitative structure-activity relationships (QSAR) of the antimalarial activity of PfDHODH inhibitors by generating four computational models using a multilinear regression (MLR) and a support vector machine (SVM) based on a dataset of 255 PfDHODH inhibitors. All the models display good prediction quality with a leave-one-out q(2) >0.66, a correlation coefficient (r) >0.85 on both training sets and test sets, and a mean square error (MSE) antimalarial activity. The models are capable of predicting inhibitors' antimalarial activity and the molecular descriptors for building the models could be helpful in the development of new antimalarial drugs.

  1. Drugs and personality: comparison of drug users, nonusers, and other clinical groups on the 16PF.

    Science.gov (United States)

    Spotts, J V; Shontz, F C

    1991-10-01

    This article reviews published 16PF research on drug users. It also compares the 16PF scores of a new sample of nonusers with scores of matched groups of heavy, chronic users of cocaine, amphetamine, opiates, and barbiturates/sedative hypnotics, as well as combined groups of stimulant users, depressant users, and a combined group of users of all substances. No significant differences were found among drug user groups, but the profile of the nonuser group was distinctive. K-Means Cluster Analyses, as well as Cattell's Similarity and Pearson Product Moment Correlation Coefficients, were used to compare profiles of these new samples with the 19 groups described in an earlier meta-analysis of published 16PF studies. Data from the new samples did not cluster with data from other published research, although certain specific similarities appeared in more detailed correlational analyses. Methodological problems are discussed, and it is recommended that in future studies drug user groups be more carefully selected and defined, sample descriptions be more thorough and complete, complete profile information be routinely provided, and efforts be made to explore the utility of the Cattell CAQ in studies of drug users/misusers.

  2. Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT.

    Science.gov (United States)

    Deane, Karen J; Summers, Robert L; Lehane, Adele M; Martin, Rowena E; Barrow, Russell A

    2014-05-08

    The emergence and spread of malaria parasites that are resistant to chloroquine (CQ) has been a disaster for world health. The antihistamine chlorpheniramine (CP) partially resensitizes CQ-resistant (CQR) parasites to CQ but possesses little intrinsic antiplasmodial activity. Mutations in the parasite's CQ resistance transporter (PfCRT) confer resistance to CQ by enabling the protein to transport the drug away from its site of action, and it is thought that resistance-reversers such as CP exert their effect by blocking this CQ transport activity. Here, a series of new structural analogues and homologues of CP have been synthesized. We show that these compounds (along with other in vitro CQ resistance-reversers) inhibit the transport of CQ via a resistance-conferring form of PfCRT expressed in Xenopus laevis oocytes. Furthermore, the level of PfCRT-inhibition was found to correlate well with both the restoration of CQ accumulation and the level of CQ resensitization in CQR parasites.

  3. Genetic analysis of suppressors of the PF10 mutation in Chlamydomonas reinhardtii

    International Nuclear Information System (INIS)

    Dutcher, S.K.; Gibbons, W.; Inwood, W.B.

    1988-01-01

    A mutation at the PF10 locus of the unicellular green alga Chlamydomonas reinhardtii leads to abnormal cell motility. The asymmetric form of the ciliary beat stroke characteristic of wild-type flagella is modified by this mutation to a nearly symmetric beat. We report here that this abnormal motility is a conditional phenotype that depends on light intensity. In the absence of light or under low light intensities, the motility is more severely impaired than at higher light intensities. By UV mutagenesis we obtained 11 intragenic and 70 extragenic strains that show reversion of the pf10 motility phenotype observed in low light. The intragenic events reverted the motility phenotype of the pf10 mutation completely. The extragenic events define at least seven suppressor loci; these map to linkage groups IV, VII, IX, XI, XII and XVII. Suppressor mutations at two of the seven loci (LIS1 and LIS2) require light for their suppressor activity. Forty-eight of the 70 extragenic suppressors were examined in heterozygous diploid cells; 47 of these mutants were recessive to the wild-type allele and one mutant (bop5-1) was dominant to the wild-type allele. Complementation analysis of the 47 recessive mutants showed unusual patterns. Most mutants within a recombinationally defined group failed to complement one another, although there were pairs that showed intra-allelic complementation. Additionally, some of the mutants at each recombinationally defined locus failed to complement mutants at other loci. They define dominant enhancers of one another

  4. Numerical study for determining PF coil system parameters in MHD equilibrium of KT-2 tokamak plasma

    International Nuclear Information System (INIS)

    Ryu, J.; Hong, S.H.; Lee, K.W.; Hong, B.G.; In, S.R.; Kim, S.K.

    1995-01-01

    The KT-2 is a large-aspect-ratio medium-sized divertor tokamak in the conceptual design phase and planned to be operational in 1998 at the Korea Atomic Energy Research Institute (KAERI). Plasma equilibrium in tokamak can be acquired by controlling the current of poloidal field (PF) coils in appropriate geometries and positions. In this study, the authors have performed numerical calculations to achieve the various equilibrium conditions fitting given plasma shapes and satisfying PF current limitations. Usually an ideal magnetohydrodynamic (MHD) equation is used to obtain the equilibrium solution of tokamak plasma, and it is practical to take advantage of a numerical method in solving the MHD equation because it has nonlinear source terms. Two equilibrium codes have been applied to find a double-null configuration of free-boundary tokamak plasma in KT-2: one is of the authors' own developing and the other is a free-boundary tokamak equilibrium code (FBT) that has been used mainly for the verification of developed code's results. PF coil system parameters including their positions and currents are determined for the optimization of input power required when the specifications of KT-2 tokamak are met. Then, several sets of equilibrium conditions during the tokamak operation are found to observe the changes of poloidal field currents with the passing of operation time step, and the basic stability problems related with the magnetic field structure is also considered

  5. The French emirs of uranium

    International Nuclear Information System (INIS)

    Lucas, N.

    1978-01-01

    The French energy plan is described under the following heads: structure of supply/use; nuclear energy; oil consumption; coal consumption; gas consumption; energy conservation; renewable resources. The section on nuclear energy covers: nuclear programmes, uranium supplies (mining and enrichment), fuel fabrication and reprocessing, finance and economics, political and administrative aspects, nuclear trade, development of fast breeder reactor. (U.K.)

  6. Progress of French nuclear programme

    International Nuclear Information System (INIS)

    Pierrard, J.-H.

    1981-02-01

    The aims of the French nuclear programme launched in 1974 are briefly recalled to mind, as are the projects completed at the end of 1980. The operating results mentioned, particularly concern the new PWR units brought into commercial service in 1980 [fr

  7. Hopes doomed for French photovoltaic

    International Nuclear Information System (INIS)

    Piro, P.

    2013-01-01

    The photovoltaic industry has lost 15000 jobs in 2 years in France and the emergency measures taken by French authorities seem to be not sufficient to curb the trend. Some measures have led to delay or even cancel some projects while what is the most important today is to generate enough activity in small and intermediate enterprises to safeguard jobs

  8. Two new French quality labels

    Energy Technology Data Exchange (ETDEWEB)

    Bresler, Ines

    2012-07-01

    'Origine France Garantie' and 'AQPV' are the new product labels that were presented in France in 2011. While the first is aimed at the entire industry, the latter is an effort to strengthen the PV industry. By raising the enthusiasm for local products, the French government hopes to keep the flood of foreign imports at bay. (orig.)

  9. English-French Cognate Dictionary.

    Science.gov (United States)

    Hammer, Petra; Monod, Madeleine

    This dictionary contains a word list of 10,993 English-French cognates (words with the same or similar spelling and meaning in both languages), including some loan words from other languages. A systematic review of the Larousse "Dictionnaire Moderne Francais--Anglais" (1960) provided this list of cognates. Deceptive cognates, or words…

  10. Fair period in French solar

    International Nuclear Information System (INIS)

    Pradel, P.

    1997-01-01

    The French solar industry decreased from 1992, but five years later, the situation changes and this industry is increasing again. The energy policy takes in account the renewable energies in a greater part, secondly, the technical reliability and a prices decreasing allow to this market to gain some ground. (N.C.)

  11. Revis(iting French palatalization

    Directory of Open Access Journals (Sweden)

    Ali Tifrit

    2016-06-01

    Full Text Available This paper explores the diachrony of French and reconsiders the classical analysis of French palatalizations. It is widely admitted that the transition from Latin dorsal stops to French palatal fricatives is triggered by an external palatalizing object which affects the constitution of the targeted consonant. While this analysis can satisfyingly explain the palatalization of dorsals before /i/, it makes the palatalization before /a/, which occurred a few centuries later, completely opaque. Revising the internal structure and the melody used to describe segments (Government Phonology 2.0 – Pöchtrager 2006 allows us to give a unified analysis of both palatalizations: whether /i/ or /a/, the vocalic environment is indeed the trigger, as it interferes with the structure of dorsals and lead to internal changes. However, while /i/ adds palatality to the consonant, /a/, by its lack of melody (Pöchtrager & Živanović 2010, leads to an internal reconfiguration of the dorsal, which already contains . In other words, we face two kinds of palatalization: an external one and an internal one. Furthermore, our analysis takes the intermediate stages from Latin dorsals to French palatals into consideration and attested dialectal variations observed in Northern France.

  12. Accident management on french PWRS

    International Nuclear Information System (INIS)

    Queniart, D.

    1990-06-01

    After a brief recall of French safety rationale, the reactor operation and severe accident management is given. The research and development aimed at developing accident management procedures and emergency organization in France for the case of a NPP accident are also given

  13. The Kyoto conference: French perspective

    International Nuclear Information System (INIS)

    Orliange Philippe

    1998-02-01

    The present article approaches the problem of the climate change from a French perspective, describing the process that let the topic acquire importance in the national government level. Also, they stand out the difficulties generated in the negotiations of the Kyoto Protocol, because the opposing positions have United States and the European block

  14. General and Professional French Courses

    CERN Document Server

    HR Department

    2011-01-01

    The next session will take place from 10th of October to 16th of December 2011. These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://hr-training.web.cern.ch/hr-training/ or contact Kerstin Fuhrmeister (kerstin.fuhrmeister@cern.ch) Oral Expression This course is aimed for students with a good knowledge of French who want to enhance their speaking skills. Speaking activities will include discussions, meeting simulations, role-plays etc. Suitable candidates should contact Kerstin Fuhrmeister (70896) or Martine Zuffi (73483) in order to arrange an appointment for a test. The next session will take place from 10th of October to 16th of December 2011. Writing professional documents in French These courses are designed for non-French speakers with a very good standard of spoken French. Suitable candidates should contact Kerstin Fuhrmeister (70896) or Martine Zuffi (73483) in order to arr...

  15. General and Professional French Courses

    CERN Multimedia

    HR Department

    2011-01-01

    The next session will take place from 30th of January to 5th of April 2012. These courses are open to all persons working on the CERN site, and to their spouses. For registration and further information on the courses, please consult our Web pages: http://hr-training.web.cern.ch/hr-training/ or contact Kerstin Fuhrmeister (kerstin.fuhrmeister@cern.ch) Oral Expression This course is aimed for students with a good knowledge of French who want to enhance their speaking skills. Speaking activities will include discussions, meeting simulations, role-plays etc. Suitable candidates should contact Kerstin Fuhrmeister (70896) or Martine Zuffi (73483) in order to arrange an appointment for a test. The next session will take place from 30th of January to 5th of April 2012. Writing professional documents in French These courses are designed for non-French speakers with a very good standard of spoken French. Suitable candidates should contact Kerstin Fuhrmeister (70896) or Martine Zuffi (73483) in order to arrange an ...

  16. Radioactivity in French bottled waters

    Energy Technology Data Exchange (ETDEWEB)

    Loyen, J.; Brassac, A.; Augeray, C.; Fayolle, C.; Gleizes, M. [Institut de Radioprotection et de Surete Nucleaire - IRSN (France)

    2014-07-01

    As IRSN is considered as a reference laboratory for radioactivity measurements, French health ministry and French nuclear safety authority asked IRSN to carry out a study in order to get a fresh and complete status of radiological water quality of French bottled waters. The study was carried out during 12 months in 2012. A total of 142 bottled waters samples were analyzed (75 spring waters and 67 natural mineral waters). The laboratories of IRSN were in charge of: - systematic measurement of radioactivity following requirements of the French health ministry (Circulaire du 13/06/2007) regarding the monitoring and management of sanitary risk linked to the presence of radionuclides in drinking waters (natural mineral waters excepted). - systematic uranium mass concentration determination; - a few radon-222 gas measurements for waters in glass bottles. This study is a flash assessment of radiological characteristics of French bottled waters, at the analysis date for the sample received. It was done in informative way and was not done for regulatory control purposes.. This study has shown that: - all bottled waters analyzed have a tritium activity concentration lower than the quality reference value of 100 Bq/l of the French regulation; - More than 105 bottled waters analyzed (80% of the springs waters and 70% of natural mineral waters received) have a gross alpha activity concentration lower than the guideline value of 0,1 Bq/l of the French regulation; - All bottled waters analyzed have a residual gross beta activity concentration lower than the guideline value of 1 Bq/l of the French regulation; - All bottled waters analyzed have a uranium mass concentration lower than the provisory guideline value of 30 μg/l of the WHO for drinking waters; - radon-222 was only significantly measured once upon 6 glass bottled waters with a value far below the reference value of 100 Bq/l of the future European Directive on drinking waters. For 32 bottled waters with gross alpha

  17. The acquisition of French in multilingual contexts

    CERN Document Server

    Guijarro-Fuentes, Pedro; Müller, Natascha

    2015-01-01

    This volume brings together new research from different theoretical paradigms addressing the acquisition of French as a second language. It focuses on the acquisition of French in combination with different languages and enriches our understanding of the particularities of French and the role of language combinations in the acquisition process.

  18. Slang Usage of French by Young Americans.

    Science.gov (United States)

    Ensz, Kathleen Y.

    1985-01-01

    Describes reactions of native French speakers to usage of French slang by young American students. French-speaking participants rated 30 tape-recorded slang expressions. Their reactions were evaluated in relation to the sex, profession, age, and residence of the respondents. Results show attitudes critical of the use of slang in general. (SED)

  19. TEACHING AND LEARNING OF FRENCH: IMPERATIVE FOR ...

    African Journals Online (AJOL)

    Prof

    It is important to note that, the teaching of French was introduced into the ... subjects like English to the detriment of French language is a proof of that .... To encourage teachers to lead the learners to use French language as a tool for .... professionals, thereby placing Nigeria at a disadvantage in terms of job creation.

  20. Commercial French in a Liberal Arts Setting.

    Science.gov (United States)

    Abrate, Jayne

    Drury College (Missouri) has developed a commercial French course that is practical, situation-oriented, and provides instruction in correspondence and translation. The course is considered part of the cultural segment of the French program. It enrolls majors in business, French, and a variety of other disciplines, and emphasizes contextual…

  1. Report: Immersion French at Meriden Junior School

    Science.gov (United States)

    Esposito, Marie-Josee

    2006-01-01

    In this article, the author describes the French immersion program at Meriden Junior School, an Anglican school for girls from pre-Kindergarten to Year 12 in Sydney. Four teachers (one of whom is the coordinator) and three assistants are involved in the program. They include six French native speakers and one non-French-born teacher who speaks…

  2. About PF

    Science.gov (United States)

    ... make scar tissue. Fibrosis : Scar tissue. Forced expiratory volume (FEV1): The amount of air you can blow out oin one second after filling up your lungs with as much air as possible. Measured by a test called spirometry. Forced vital capacity (FVC): The amount of air you can blow ...

  3. Synthesis and preclinical evaluation of [11C-carbonyl]PF-04457845 for neuroimaging of fatty acid amide hydrolase

    International Nuclear Information System (INIS)

    Hicks, Justin W.; Parkes, Jun; Sadovski, Oleg; Tong, Junchao; Houle, Sylvain; Vasdev, Neil; Wilson, Alan A.

    2013-01-01

    Introduction: Fatty acid amide hydrolase (FAAH) has a significant role in regulating endocannabinoid signaling in the central nervous system. As such, FAAH inhibitors are being actively sought for pain, addiction, and other indications. This has led to the recent pursuit of positron emission tomography (PET) radiotracers targeting FAAH. We report herein the preparation and preclinical evaluation of [ 11 C-carbonyl]PF-04457845, an isotopologue of the potent irreversible FAAH inhibitor. Methods: PF-04457845 was radiolabeled at the carbonyl position via automated [ 11 C]CO 2 -fixation. Ex vivo brain biodistribution of [ 11 C-carbonyl]PF-04457845 was carried out in conscious rats. Specificity was determined by pre-administration of PF-04457845 or URB597 prior to [ 11 C-carbonyl]PF-04457845. In a separate experiment, rats injected with the title radiotracer had whole brains excised, homogenized and extracted to examine irreversible binding to brain parenchyma. Results: The title compound was prepared in 5 ± 1% (n = 4) isolated radiochemical yield based on starting [ 11 C]CO 2 (decay uncorrected) within 25 min from end-of-bombardment in > 98% radiochemical purity and a specific activity of 73.5 ± 8.2 GBq/μmol at end-of-synthesis. Uptake of [ 11 C-carbonyl]PF-04457845 into the rat brain was high (range of 1.2–4.4 SUV), heterogeneous, and in accordance with reported FAAH distribution. Saturable binding was demonstrated by a dose-dependent reduction in brain radioactivity uptake following pre-treatment with PF-04457845. Pre-treatment with the prototypical FAAH inhibitor, URB597, reduced the brain radiotracer uptake in all regions by 71–81%, demonstrating specificity for FAAH. The binding of [ 11 C-carbonyl]PF-04457845 to FAAH at 40 min post injection was irreversible as 98% of the radioactivity in the brain could not be extracted. Conclusions: [ 11 C-carbonyl]PF-04457845 was rapidly synthesized via an automated radiosynthesis. Ex vivo biodistribution studies in

  4. A study of young Parisian speech

    DEFF Research Database (Denmark)

    Hansen, Anita Berit

    2012-01-01

    Fransk talt i Paris har gennem århundrede udgjort en model for den øvrige franske befolkning. Udtalen er dog på ingen måde fri for variation eller forandring. Artiklen behandler udtalen hos 9 unge parisere (såvel studerende som personer med kort teknisk uddannelse), der tydeligvis deltager i flere...

  5. An Examination of the Relationship of the 16PF Fifth Edition to a Multidimensional Model of Self-Esteem

    OpenAIRE

    Dale Pietrzak; Betsy Page; James S. Korcuska; Amber Bach Gorman

    2015-01-01

    The regression equation needed to predict the self-esteem score from the Sixteen Personality Factor Questionnaire (16PF) Fifth Edition is not available for hand scoring. This score is derived from the Coopersmith’s Self-Esteem Inventory (SEI), which is based on a unitary model of self-esteem. The SEI may be subject to gender and extroversion biases. Moreover, there is a gap in the literature on the 16PF fifth edition a...

  6. Studies on the thermal decomposition kinetics of LiPF6 and LiBC4O8

    Indian Academy of Sciences (India)

    WINTEC

    ion batteries. The current electrolyte generally used in lithium-ion batteries is mainly composed of LiPF6 and a blend of alkyl carbonates. LiPF6 has been widely adopted for more than a decade, owing to its neces- sary pre-requisites for use in lithium ion batteries, for example, it is easily soluble in various solvents, can lead ...

  7. Potentially functional SNPs (pfSNPs as novel genomic predictors of 5-FU response in metastatic colorectal cancer patients.

    Directory of Open Access Journals (Sweden)

    Jingbo Wang

    Full Text Available 5-Fluorouracil (5-FU and its pro-drug Capecitabine have been widely used in treating colorectal cancer. However, not all patients will respond to the drug, hence there is a need to develop reliable early predictive biomarkers for 5-FU response. Here, we report a novel potentially functional Single Nucleotide Polymorphism (pfSNP approach to identify SNPs that may serve as predictive biomarkers of response to 5-FU in Chinese metastatic colorectal cancer (CRC patients. 1547 pfSNPs and one variable number tandem repeat (VNTR in 139 genes in 5-FU drug (both PK and PD pathway and colorectal cancer disease pathways were examined in 2 groups of CRC patients. Shrinkage of liver metastasis measured by RECIST criteria was used as the clinical end point. Four non-responder-specific pfSNPs were found to account for 37.5% of all non-responders (P<0.0003. Five additional pfSNPs were identified from a multivariate model (AUC under ROC = 0.875 that was applied for all other pfSNPs, excluding the non-responder-specific pfSNPs. These pfSNPs, which can differentiate the other non-responders from responders, mainly reside in tumor suppressor genes or genes implicated in colorectal cancer risk. Hence, a total of 9 novel SNPs with potential functional significance may be able to distinguish non-responders from responders to 5-FU. These pfSNPs may be useful biomarkers for predicting response to 5-FU.

  8. Multiple ETS family proteins regulate PF4 gene expression by binding to the same ETS binding site.

    Directory of Open Access Journals (Sweden)

    Yoshiaki Okada

    Full Text Available In previous studies on the mechanism underlying megakaryocyte-specific gene expression, several ETS motifs were found in each megakaryocyte-specific gene promoter. Although these studies suggested that several ETS family proteins regulate megakaryocyte-specific gene expression, only a few ETS family proteins have been identified. Platelet factor 4 (PF4 is a megakaryocyte-specific gene and its promoter includes multiple ETS motifs. We had previously shown that ETS-1 binds to an ETS motif in the PF4 promoter. However, the functions of the other ETS motifs are still unclear. The goal of this study was to investigate a novel functional ETS motif in the PF4 promoter and identify proteins binding to the motif. In electrophoretic mobility shift assays and a chromatin immunoprecipitation assay, FLI-1, ELF-1, and GABP bound to the -51 ETS site. Expression of FLI-1, ELF-1, and GABP activated the PF4 promoter in HepG2 cells. Mutation of a -51 ETS site attenuated FLI-1-, ELF-1-, and GABP-mediated transactivation of the promoter. siRNA analysis demonstrated that FLI-1, ELF-1, and GABP regulate PF4 gene expression in HEL cells. Among these three proteins, only FLI-1 synergistically activated the promoter with GATA-1. In addition, only FLI-1 expression was increased during megakaryocytic differentiation. Finally, the importance of the -51 ETS site for the activation of the PF4 promoter during physiological megakaryocytic differentiation was confirmed by a novel reporter gene assay using in vitro ES cell differentiation system. Together, these data suggest that FLI-1, ELF-1, and GABP regulate PF4 gene expression through the -51 ETS site in megakaryocytes and implicate the differentiation stage-specific regulation of PF4 gene expression by multiple ETS factors.

  9. Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study)

    DEFF Research Database (Denmark)

    Nguyen, Quan Dong; Schachar, Ronald A; Nduaka, Chudy I

    2012-01-01

    To evaluate the safety and efficacy of three doses of PF-04523655, a 19-nucleotide methylated double stranded siRNA targeting the RTP801 gene, for the treatment of diabetic macular edema (DME) compared to focal/grid laser photocoagulation.......To evaluate the safety and efficacy of three doses of PF-04523655, a 19-nucleotide methylated double stranded siRNA targeting the RTP801 gene, for the treatment of diabetic macular edema (DME) compared to focal/grid laser photocoagulation....

  10. Situation of the surveillance of radioactivity in French Polynesia in 2007. Results of the I.R.S.N. 's surveillance network

    International Nuclear Information System (INIS)

    2008-01-01

    The 543 atmospheric nuclear tests released radionuclides that have deposited themselves throughout the world. The Environmental Study and Surveillance Laboratory, 'Laboratoire d etude et de suivi de l'environnement' (L.E.S.E.) of the Institute of nuclear safety and radiation protection (I.R.S.N.), takes part, for more than 35 years, in the evaluation of the dosimetric consequences of these atmospheric depositions, especially those originating with the 41 tests realized in the territory of French polynesia from 1966 to 1974. This laboratory is established in Tahiti. The actualized dosimetric evaluation due to the foodstuff ingestion requires to collect the most representative samples of the feed ration of the Polynesians living in the 5 archipelagoes of this territory. These samples belong to the marine environment of full sea, the lagoon environment and the terrestrial environment. Certain samples of the physical environment are also taken (air, water). 355 samples collected in 2007 are measured by Hp-Ge low background gamma spectrometry in order to be able to characterize lowest possible radioactivity levels. The levels of activity of Pu isotopes and 90 Sr are also given for 50 selected samples and tritium activities for 20 water samples. After a period of regular decay of radioactivity after the stop, in 1974, of the French atmospheric tests, the radiological state observed in the year 2007 is the same of that of the recent previous years, at a very low level. for example, the 137 Cs rate in the polynesian air is ten times lower than the parisian rate. In fact, the residual radioactivity essentially relates to 137 Cs, the only artificial radionuclide still measurable in the archipelago. In term of additional dose, this artificial and residual radioactivity is lower than 6 μSv by year. this value corresponds to less than 1% of exposure due to natural radioactivity in Polynesia (approximately 1 milli Sv). (N.C.)

  11. Engineering Pseudomonas protegens Pf-5 for Nitrogen Fixation and its Application to Improve Plant Growth under Nitrogen-Deficient Conditions

    Science.gov (United States)

    Setten, Lorena; Soto, Gabriela; Mozzicafreddo, Matteo; Fox, Ana Romina; Lisi, Christian; Cuccioloni, Massimiliano; Angeletti, Mauro; Pagano, Elba; Díaz-Paleo, Antonio; Ayub, Nicolás Daniel

    2013-01-01

    Nitrogen is the second most critical factor for crop production after water. In this study, the beneficial rhizobacterium Pseudomonas protegens Pf-5 was genetically modified to fix nitrogen using the genes encoding the nitrogenase of Pseudomonas stutzeri A1501 via the X940 cosmid. Pf-5 X940 was able to grow in L medium without nitrogen, displayed high nitrogenase activity and released significant quantities of ammonium to the medium. Pf-5 X940 also showed constitutive expression and enzymatic activity of nitrogenase in ammonium medium or in nitrogen-free medium, suggesting a constitutive nitrogen fixation. Similar to Pseudomonas protegens Pf-5, Pseudomonas putida, Pseudomonas veronii and Pseudomonas taetrolens but not Pseudomonas balearica and Pseudomonas stutzeri transformed with cosmid X940 showed constitutive nitrogenase activity and high ammonium production, suggesting that this phenotype depends on the genome context and that this technology to obtain nitrogen-fixing bacteria is not restricted to Pf-5. Interestingly, inoculation of Arabidopsis, alfalfa, tall fescue and maize with Pf-5 X940 increased the ammonium concentration in soil and plant productivity under nitrogen-deficient conditions. In conclusion, these results open the way to the production of effective recombinant inoculants for nitrogen fixation on a wide range of crops. PMID:23675499

  12. The relationship of French people with energy

    International Nuclear Information System (INIS)

    Levy, Jean-Daniel; Potereau, Julien; Gautier, Antoine

    2017-12-01

    This Power Point document presents graphs and tables containing results of a survey performed on the relationship French people have with energy. After a presentation of the survey methodology, it addresses how France commitment in the struggle against climate change is perceived (French people think that their country could do better), which perceptions French people have of stakes and of the French energy policy (the management of the energy issue is perceived as perfectible, and French people have a positive view on energy transition and on the development of renewable energies), and which investments French people stand for (French people are in favour of a more important role of Europe and of citizen cooperatives in the field of energy)

  13. French Prime Minister tours CERN

    CERN Multimedia

    Anaïs Schaeffer

    2012-01-01

    On 30 July, Jean-Marc Ayrault, the Prime Minister of the French Republic, and Geneviève Fioraso, the Minister of Higher Education and Research, visited the Laboratory.   After being met by the Director-General at LHC Point 5, they visited the CMS control centre and experiment cavern, and got a glimpse of the LHC tunnel at Point 5. The visit ended with a round-table discussion with French and other international members of CERN’s scientific community. During the discussion, the Prime Minister reaffirmed that “support for fundamental research has to be maintained, and France must continue to invest in education, research and innovation.” He also paid tribute to CERN's role in international cooperation, which he qualified as “a fine example of science without borders.”

  14. French people and energy issues

    International Nuclear Information System (INIS)

    Chesnais, L.

    2006-01-01

    An opinion poll made in France in 2006 shows that: - French people backs nuclear energy with a slight margin (45% versus 42%), - French people agrees with the electricity production policy led by the government, - about 4 people out of 10 expect a sharp increase in prices concerning car fuels, natural gas and heating fuels in a near future, on the other hand fewer people than in previous years are expecting a price rise for electricity. In this article some figures concerning the consumption of energy in France are given: - 230.000 jobs are directly or indirectly involved in the energy sector, this sector represents 5% of all investment, - a total bill of 24 milliard euros for the energy imports, and - energy spending represents 7.6% of the household budget. (A.C.)

  15. Venus transits - A French view

    Science.gov (United States)

    Débarbat, Suzanne

    2005-04-01

    After a careful study of Mars observations obtained by Tycho Brahé (1546-1601), Kepler (1571-1630) discovered the now-called Kepler's third law. In 1627 he published his famous Tabulae Rudolphinae, a homage to his protector Rudolph II (1552-1612), tables (Kepler 1609, 1627) from which he predicted Mercury and Venus transits over the Sun. In 1629 Kepler published his Admonitio ad Astronomos Advertisement to Astronomers (Kepler 1630), Avertissement aux Astronomes in French Au sujet de phénomènes rares et étonnants de l'an 1631: l'incursion de Vénus et de Mercure sur le Soleil. This was the beginning of the interest of French astronomers, among many others, in such transits, mostly for Venus, the subject of this paper in which dates are given in the Gregorian calendar.

  16. French people and nuclear wastes

    International Nuclear Information System (INIS)

    D'Iribarne, Ph.

    2005-01-01

    On March 21, 2005, the French minister of industry gave to the author of this document, the mission to shade a sociological light on the radioactive wastes perception by French people. The objective of this study was to supply an additional information before the laying down in 2006 of the decisions about the management of high-level and long-lived radioactive wastes. This inquiry, carried out between April 2004 and March 2005, stresses on the knowledge and doubts of the questioned people, on the vision they have of radioactive wastes and of their hazards, and on their opinion about the actors in concern (experts, nuclear companies, government, anti-nuclear groups, public). The last two parts of the report consider the different ways of waste management under study today, and the differences between the opinion of people living close to the Bure site and the opinion of people living in other regions. (J.S.)

  17. New french uranium mineral species

    International Nuclear Information System (INIS)

    Branche, G.; Chervet, J.; Guillemin, C.

    1952-01-01

    In this work, the authors study the french new uranium minerals: parsonsite and renardite, hydrated phosphates of lead and uranium; kasolite: silicate hydrated of uranium and lead uranopilite: sulphate of uranium hydrated; bayleyite: carbonate of uranium and of hydrated magnesium; β uranolite: silicate of uranium and of calcium hydrated. For all these minerals, the authors give the crystallographic, optic characters, and the quantitative chemical analyses. On the other hand, the following species, very rare in the french lodgings, didn't permit to do quantitative analyses. These are: the lanthinite: hydrated uranate oxide; the α uranotile: silicate of uranium and of calcium hydrated; the bassetite: uranium phosphate and of hydrated iron; the hosphuranylite: hydrated uranium phosphate; the becquerelite: hydrated uranium oxide; the curite: oxide of uranium and lead hydrated. Finally, the authors present at the end of this survey a primary mineral: the brannerite, complex of uranium titanate. (author) [fr

  18. French concepts of ''passive safety''

    International Nuclear Information System (INIS)

    Dennielou, Y.; Serret, M.

    1990-01-01

    N 4 model, the French 1400 MW PWR of the 90's, exhibits many advanced features. As far as safety is concerned, the fully computerized control room design takes advantage of the operating experience feedback and largely improves the man machine interface. New post-accident procedures have been developed (the so-called ''physical states oriented procedures''). A complete consistent set of ''Fundamental Safety Rules'' have been issued. This however doesn't imply any significant modification of standard PWR with regard to the passive aspects of safety systems or functions. Nevertheless, traditional PWR safety systems largely use passive aspects: natural circulation, reactivity coefficients, gravity driven control rods, injection accumulators, so on. Moreover, probability calculations allow for comparison between the respective contributions of passive and of active failures. In the near future, eventual options of future French PWRs to be commissioned after 2000 will be evaluated; simplification, passive and forgiving aspects of safety systems will be thoroughly considered. (author)

  19. Reminder: Swiss and French cards

    CERN Multimedia

    2012-01-01

    Communication from the HR Department to members of personnel holding an employment or association contract, above 50% and for more than 3 months, with the Organization. The HR Department would like to remind all members of personnel concerned that they are obliged to: • hold a valid Swiss  Légitimation card AND a valid French card (“Titre de séjour spécial” or “attestation de fonctions”) at all times during the exercise of their functions in the Organization; • return these documents as soon as their functions in the Organization cease. Not following these rules could be prejudicial to the Organization and appropriate measures may be taken towards the member of personnel concerned. Information and procedures concerning Swiss and French cards (first application, renewal, theft/loss, etc.) are available in the Admin e-guide. Users and Unpaid Associates must contact the Users Office HR Department Tel.: 729...

  20. Swiss and French cards - Reminder

    CERN Multimedia

    HR Department

    2011-01-01

    Communication from the HR Department to members of personnel holding an employment or association contract, above 50% and for more than 3 months, with the Organization. The HR Department would like to remind all members of the personnel concerned that they are obliged to: hold a valid Swiss Légitimation card AND a valid French card (“Titre de séjour spécial” or “attestation de fonctions”) at all times during the exercise of their functions in the Organization; return these documents as soon as their functions in the Organization cease. Not following these rules could be prejudicial to the Organization and appropriate measures may be taken with respect to the member of the personnel concerned. Information and procedures concerning Swiss and French cards (first application, renewal, theft/loss, etc.) are available in the Admin e-guide: https://cern.ch/admin-eguide/cartes/proc_cartes_home.asp Users and Unpaid Associates must ...

  1. PWR standardization: The French experience

    International Nuclear Information System (INIS)

    Bacher, P.E.

    1987-01-01

    After a short historical review of the French PWR programme with 45000 MWe in operation and 15000 MWe under construction, the paper first develops the objectives and limits of the standardizatoin policy. Implementation of standardization is described through successive reactor series and feedback of experience, together with its impact on safety and on codes and standards. Present benefits of standardization range from low engineering costs to low backfitting costs, via higher quality, reduction in construction times and start-up schedules and improved training of operators. The future of the French programme into the 1990's is again with an advanced standardized series, the N4-1400 MW plant. There is no doubt that the very positive experience with standardization is relevant to any country trying to achieve self-reliance in the nuclear power field. (author)

  2. New Abbreviations in Colloquial French

    Directory of Open Access Journals (Sweden)

    Vladimir Pogačnik

    2015-12-01

    Full Text Available The author of the article treats the process of abbreviations, which he explored forty years ago in his master thesis. The article is based on the corpus created on the basis of Télématin broadcast on French television network TV5. According to the author, clipping is a widespread process that occurs primarily in various forms of oral communication.

  3. The French natural gas industry

    International Nuclear Information System (INIS)

    1999-01-01

    This little folder summarizes in few pages the main economical data of the French natural gas industry: supplies according to the country of origin, length of transport and distribution networks, LNG tanker ship fleet, underground storage capacity, population of LNG-fueled vehicles, cogeneration installations, consumption by sectors and by industrial activities, LPG consumption, supplies, distribution and sales, LPG-fuel for vehicles, CO 2 and NO x releases, equipment of households. (J.S.)

  4. Food studies in French History

    DEFF Research Database (Denmark)

    Hedegaard, Liselotte

    The overarching question of this paper is whether it is possible to identify concepts that define a specifically French tradition regarding food. Two themes seem central. The first theme is the relationship between food and place as it emerges in concepts such as authenticity and terroir....... The second theme is the "how" food is eaten and can be studied through concepts such as commensality, synchronisation and structure...

  5. The French deterrence from 1945

    International Nuclear Information System (INIS)

    Bouchard, J.

    1997-01-01

    Here is presented a particular lighting of deterrence history, by sciences and technologies which have allowed their creation and development. Accompanying the historical evolution of the French deterrence forces during the first phase of these sciences constitution, these sciences and technologies are at the base of the nuclear weapons conception, but they also contributed to the realization of the industrial building and to a doctrine constitution. (N.C.)

  6. French opinion on Nuclear Energy

    International Nuclear Information System (INIS)

    Bucaille, A.

    2003-01-01

    Contrary to what many think or say, most French people do not have a clear-cut opinion about nuclear power. And until public opinion can be accurately assessed, we should be worried of speaking on its behalf. More than half the population of France believes that nuclear power is the cheapest option, but 40% of them have no idea what the situation really is. The French are keenly aware of the what is at stake at the international level, and the fact that energy is becoming a worldwide issue. What they are most concerned about is nuclear waste and the possibility of a catastrophe of the Chernobyl type occurring. Disquiet about the first is now dissipating, after having increased. But attitudes about the second are ambivalent. A quarter of the French are very ignorant about radioactivity. 20% of the population complain that not enough information is forthcoming, particularly as concerns advances in technology. As can be anticipated, awareness of the question of climate change is growing year by year, with increased reporting of storms, floods and heat waves

  7. The Plasmodium falciparum exported protein PF3D7_0402000 binds to erythrocyte ankyrin and band 4.1

    Energy Technology Data Exchange (ETDEWEB)

    Shakya, Bikash; Penn, Wesley D.; Nakayasu, Ernesto S.; Lacount, Douglas J.

    2017-09-01

    Plasmodium falciparum extensively modifies the infected red blood cell (RBC), resulting in changes in deformability, shape and surface properties. These alterations suggest that the RBC cytoskeleton is a major target for modification during infection. However, the molecular mechanisms leading to these changes are largely unknown. To begin to address this question, we screened for exported P. falciparum proteins that bound to the erythrocyte cytoskeleton proteins ankyrin 1 (ANK1) and band 4.1 (4.1R), which form critical interactions with other cytoskeletal proteins that contribute to the deformability and stability of RBCs. Yeast two-hybrid screens with ANK1 and 4.1R identified eight interactions with P. falciparum exported proteins, including an interaction between 4.1R and PF3D7_0402000 (PFD0090c). This interaction was first identified in a large-scale screen (Vignali et al., Malaria J, 7:211, 2008), which also reported an interaction between PF3D7_0402000 and ANK1. We confirmed the interactions of PF3D7_0402000 with 4.1R and ANK1 in pair-wise yeast two-hybrid and co-precipitation assays. In both cases, an intact PHIST domain in PF3D7_0402000 was required for binding. Complex purification followed by mass spectrometry analysis provided additional support for the interaction of PF3D7_0402000 with ANK1 and 4.1R. RBC ghost cells loaded with maltose-binding protein (MBP)-PF3D7_0402000 passed through a metal microsphere column less efficiently than mock- or MBP-loaded controls, consistent with an effect of PF3D7_0402000 on RBC rigidity or membrane stability. This study confirmed the interaction of PF3D7_0402000 with 4.1R in multiple independent assays, provided the first evidence that PF3D7_0402000 also binds to ANK1, and suggested that PF3D7_0402000 affects deformability or membrane stability of uninfected RBC ghosts.

  8. Evaluation of fuel-temperature feedback mechanisms in TRAC-PF1/MOD2/NESTLE

    International Nuclear Information System (INIS)

    Knepper, Paula L.; Feltus, Madeline; Hochreiter, L.E.; Ivanov, Kostadin

    1999-01-01

    Coupled spatial kinetics and thermal-hydraulics system codes provide a means to model transient nuclear reactor behavior more accurately. Transients marked by strong perturbations, both with thermal-hydraulics and neutronics, such as a control-rod ejection or a main steam-line break, are especially of interest. It is now feasible to model complex reactor behavior with a coupled thermal-hydraulics and spatial kinetics code that provides a means to forecast safety margins. Recently, the Transient Reactor Analysis Code (TRAC)-PF1/MOD2, Version 5.4.25, was coupled with the NESTLE code. This coupled code (TRAC-PF1/MOD2/NESTLE) is used to examine effective fuel-temperature models. The Electric Power Research Institute (EPRI) rod-ejection benchmark was analyzed to evaluate the influence of effective fuel temperature. The rod-ejection transient tests only the fuel-rod, heat-conduction coupling. The coolant thermal-hydraulic coupling is not tested because of the speed of the transient. The neutronics solution changes extremely rapidly, whereas the convective heat transfer at the fuel surface requires more time to influence the coolant temperature of the system. The need to model the response of the system coolant temperature is not crucial in this analysis. The influence of the effective fuel temperature is the key component of this study. Various models were examined using the coupled code to calculate effective fuel temperatures. The influence of different, effective fuel-temperature models on the coupled-code results is studied. Three effective fuel-temperature models are examined: (l) volume average effective fuel temperature, (2) the effective fuel-temperature model suggested by the Office of Economic Cooperation and Development (OECD) rod-ejection benchmark, and (3) the NESTLE effective fuel-temperature model. A discussion is provided describing the effective fuel-temperature models examined in TRAC-PF1/MOD2/NESTLE and the influence of effective fuel temperature in

  9. Diagnostics of PF-1000 facility operation and plasma concentration on the basis of spectral measurements

    International Nuclear Information System (INIS)

    Skladnik-Sadowska, E.; Malinowski, K.; Sadowski, M.J.; Scholz, M.; Tsarenko, A.V.

    2005-01-01

    The paper concerns the monitoring of the operation of high-current pulse discharges and the determination of the plasma concentration within the dense magnetized plasma column by means of optical spectroscopy methods. In experiments performed within the large PF-1000 facility, which is operated at IPPLM in Warsaw, particular attention was paid to possibility of the determination of correctness of the operational mode. In order to measure the visible radiation (VR), as emitted from the collapsing current sheath and the dense pinch region, the use was made of the MECHELLE R 900-optical-spectrometer, which was equipped with a CCD measuring head. The spectral measurements were performed at an angle of about 650 to the symmetry axis of the PF electrode system, through an optical window and a special collimator coupled with the quartz optical-cable. The observed VR emission originated from a part of the inner- and outer-electrode surfaces, the collapsing current-sheath layer and a portion of the dense plasma pinch-region (located a distance of 40-50 mm from the electrode ends). Considerable differences were found in the optical spectra recorded for so-called good shots and for cases of some failures. In the case of a breakdown (damage) of the main insulator there were observed different Al-lines, which originated from the eroded insulator material. At so-called bad vacuum conditions there were recorded various C-lines, and at an uncontrolled air-leakage into the experimental chamber there appeared numerous N-lines. The appearance of these characteristic spectral lines made possible to determine whether the operation of the PF-1000 facility was correct or incorrect. The paper reports also on estimates of plasma concentration values, which have been performed on the basis of a quantitative analysis of the Stark broadening of the selected spectral lines. (author)

  10. Glass transition in the spin-density wave phase of (TMTSF)2PF6

    DEFF Research Database (Denmark)

    Lasjaunias, J.C.; Biljakovic, K.; Nad, F.

    1994-01-01

    We present the results of low frequency dielectric measurements and a detailed kinetic investigation of the specific heat anomaly in the spin-density wave phase of (TMTSF)(2)PF6 in the temperature range between 2 and 4 K. The dielectric relaxation shows a critical slowing down towards a ''static'......'' glass transition around 2 K. The jump in the specific heat in different controlled kinetic conditions shows all the characteristics of freezing in supercooled liquids. Both effects give direct evidence of a glass transition in the spin-density wave ground state....

  11. Current Sharing Analysis of Arm Prototype for ITER PF Converter Bridge

    International Nuclear Information System (INIS)

    Li Jinchao; Song Zhiquan; Xu Liuwei; Fu Peng; Guo Bin; Li Sen; Dong Lin; Wang Min

    2014-01-01

    A bridge arm prototype of ITER poloidal field (PF) converter modules has been designed and fabricated. Non-cophase counter parallel connection is chosen as the arm structure of the prototype. Among all factors affecting current sharing, arm structure is the main one. During the design of the arm prototype, a novel method based on inductance matrixes is employed to improve the current sharing of the bridge arm. The test results on the prototype show that the current sharing performance of the arm prototype is much better than relevant design requirement, and that the matrix method is very effective to analyze and solve the current sharing problems of thyristor converters

  12. Suppression of Longitudinal Coupled-Bunch Instabilities at the KEK-PF

    International Nuclear Information System (INIS)

    Obina, T.; Tobiyama, M.; Honda, T.; Tadano, M.; Flanagan, J.W.; Mitsuhashi, T.; Cheng, W.X.; Fox, J.D.; Teytelman, D.

    2012-01-01

    A bunch-by-bunch feedback system has been developed to suppress longitudinal coupled-bunch instabilities at the KEK-PF. A longitudinal kicker based on a DAFNE-type overdamped cavity has been designed and installed in the ring, and a general purpose signal processor, called iGp, has been developed by the collaboration of the KEK, SLAC, and INFN-LNF. The entire feedback loop has been closed by the end of June 2007, and the feedback system has successfully suppressed the longitudinal dipole-mode instabilities up to 430 mA.

  13. Revisión sistemática del Cuestionario Factorial de Personalidad (16PF)

    OpenAIRE

    Sánchez-Gallego, Nancy Janeth; Gómez-Macías, Carolina; Zambrano-Cruz, Renato

    2011-01-01

    Este artículo busca establecer el uso e impacto de la prueba de personalidad 16PF en publicaciones académicas durante el periodo 2000-2010. Para lograr dicho objetivo en esta investigación documental se utilizó la metodología de revisión sistemática de literatura en la que se encontraron 30 artículos que cumplen con los criterios de inclusión. Se observa que la prueba ha sido utilizada en diversas investigaciones alrededor del mundo de manera constante,aunque se discute el uso de la cuarta ed...

  14. Validity study of the 16PF in terminal air traffic control work

    International Nuclear Information System (INIS)

    Karson, S.; O'Dell, J.W.

    1976-01-01

    Personality test scores obtained in 1966 from the 16PF, Form A are compared with supervisory ratings on overall job ability made at least two years later on a sample of 510 terminal area journeymen controllers. Those rated above average were found to differ significantly from those rated below average in ability on one primary personality factor, namely, C (ego strength). Other factors which approached significance are also discussed. The present study represents an attempt to determine whether personality factor scores are valid over longer periods of time in successfully discriminating journeymen terminal controllers rated above and below average in overall ability by their supervisors

  15. Recent studies of the ion emission from high-current PF-1000 experiments

    International Nuclear Information System (INIS)

    Skladnik-Sadowska, E.; Sadowski, M.J.; Czaus, K.; Malinowski, K.; Kwiatkowski, R.; Zebrowski, J.; Sadowski, M.J.; Karpinski, L.; Paduch, M.; Scholz, M.; Garkusha, I.E.

    2010-01-01

    The paper describes diagnostics of fast ion beams emitted from a large PF-1000 facility operated at 21...27 kV, 290...480 kJ. Those beams were measured with pinhole cameras and PM-355 nuclear track detectors, placed at different angles to the discharge axis. The measurements showed a complex spatial structure of the fast ion beams. Measurements behind an axial channel in the inner electrode have shown that some ion beams are emitted also in the upstream direction. The ion energy spectra were measured with a miniature Thomson-type spectrometer. Time-resolved measurements of ions were performed with miniature scintillation detectors placed behind a pinhole.

  16. Vibrational autoionization in PF3: Doing violence to the propensity rule

    International Nuclear Information System (INIS)

    Berkowitz, J.; Greene, J.P.

    1984-01-01

    The photoionization spectrum of PF + 3 in its threshold region displays two prominent progressions of autoionization peaks. When these are analyzed, together with earlier photoabsorption studies and a photoelectron spectrum, they lead to the conclusion that vibrational autoionization is occurring, with Δν< or =-13. This conclusion stands in sharp contrast with the current theory of vibrational autoionization, which predicts a propensity rule Δν = -1. Other examples from the recent literature are summarized, to suggest that a more general theory of vibrational autoionization is required

  17. PF-4708671, a specific inhibitor of p70 ribosomal S6 kinase 1, activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jeong Su [Severance Biomedical Science Institute (Korea, Republic of); Yonsei Biomedical Research Institute, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752 (Korea, Republic of); Kang, Dong Hoon [Department of Life Science and Ewha Research Center for Systems Biology (Korea, Republic of); The Research Center for Cell Homeostasis, Ewha Womans University, Seoul 127-750 (Korea, Republic of); Lee, Da Hyun [Severance Biomedical Science Institute (Korea, Republic of); Yonsei Biomedical Research Institute, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752 (Korea, Republic of); Bae, Soo Han, E-mail: soohanbae@yuhs.ac [Severance Biomedical Science Institute (Korea, Republic of); Yonsei Biomedical Research Institute, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752 (Korea, Republic of)

    2015-10-23

    p70 ribosomal S6 kinase 1 (S6K1) is an important serine/threonine kinase and downstream target of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway. PF-4708671 is a specific inhibitor of S6K1, and prevents S6K1-mediated phosphorylation of the S6 protein. PF-4708671 treatment often leads to apoptotic cell death. However, the protective mechanism against PF-4708671-induced cell death has not been elucidated. The nuclear factor erythroid 2-related factor 2 (Nrf2)-Kelch-like ECH-associated protein 1 (Keap1) pathway is essential for protecting cells against oxidative stress. p62, an adaptor protein in the autophagic process, enhances Nrf2 activation through the impairment of Keap1 activity. In this study, we showed that PF-4708671 induces autophagic Keap1 degradation-mediated Nrf2 activation in p62-dependent manner. Furthermore, p62-dependent Nrf2 activation plays a crucial role in protecting cells from PF-4708671-mediated apoptosis. - Highlights: • PF-4708671, a S6K1-specific inhibitor, prevents S6K1-mediated S6 phosphorylation. • However, PF-4708671 treatment often leads to apoptotic cell death. • Protective mechanism against PF-4708671-induced cell death remains to be elucidated. • PF-4708671 induced p62-dependent, autophagic Keap1 degradation-mediated Nrf2 activation. • p62-dependent Nrf2 activation protects cells from PF-4708671-mediated apoptosis.

  18. A method for visualizing surface-exposed and internal PfEMP1 adhesion antigens in Plasmodium falciparum infected erythrocytes

    Directory of Open Access Journals (Sweden)

    Arnot David E

    2008-06-01

    Full Text Available Abstract Background The insertion of parasite antigens into the host erythrocyte membrane and the structure and distribution of Plasmodium falciparum adhesion receptors on that membrane are poorly understood. Laser scanning confocal microscopy (LSCM and a novel labelling and fixation method have been used to obtain high resolution immuno-fluorescent images of erythrocyte surface PfEMP1 and internal antigens which allow analysis of the accumulation of PfEMP1 on the erythrocyte membrane during asexual development. Methods A novel staining technique has been developed which permits distinction between erythrocyte surface PfEMP1 and intracellular PfEMP1, in parasites whose nuclear material is exceptionally well resolved. Primary antibody detection by fluorescence is carried out on the live parasitized erythrocyte. The surface labelled cells are then fixed using paraformaldehyde and permeabilized with a non-ionic detergent to permit access of antibodies to internal parasite antigens. Differentiation between surface and internal antigens is achieved using antibodies labelled with different fluorochromes and confocal microscopy Results Surface exposed PfEMP1 is first detectable by antibodies at the trophozoite stage of intracellular parasite development although the improved detection method indicates that there are differences between different laboratory isolates in the kinetics of accumulation of surface-exposed PfEMP1. Conclusion A sensitive method for labelling surface and internal PfEMP1 with up to three different fluorochromes has been developed for laser scanning confocal optical microscopy and the analysis of the developmental expression of malaria adhesion antigens.

  19. Transcript and protein expression profile of PF11_0394, a Plasmodium falciparum protein expressed in salivary gland sporozoites

    Directory of Open Access Journals (Sweden)

    Schlarman Maggie S

    2012-03-01

    Full Text Available Abstract Background Plasmodium falciparum malaria is a significant problem around the world today, thus there is still a need for new control methods to be developed. Because the sporozoite displays dual infectivity for both the mosquito salivary glands and vertebrate host tissue, it is a good target for vaccine development. Methods The P. falciparum gene, PF11_0394, was chosen as a candidate for study due to its potential role in the invasion of host tissues. This gene, which was selected using a data mining approach from PlasmoDB, is expressed both at the transcriptional and protein levels in sporozoites and likely encodes a putative surface protein. Using reverse transcription-polymerase chain reaction (RT-PCR and green fluorescent protein (GFP-trafficking studies, a transcript and protein expression profile of PF11_0394 was determined. Results The PF11_0394 protein has orthologs in other Plasmodium species and Apicomplexans, but none outside of the group Apicomplexa. PF11_0394 transcript was found to be present during both the sporozoite and erythrocytic stages of the parasite life cycle, but no transcript was detected during axenic exoerythrocytic stages. Despite the presence of transcript throughout several life cycle stages, the PF11_0394 protein was only detected in salivary gland sporozoites. Conclusions PF11_0394 appears to be a protein uniquely detected in salivary gland sporozoites. Even though a specific function of PF11_0394 has not been determined in P. falciparum biology, it could be another candidate for a new vaccine.

  20. Plasmodium falciparum Hop (PfHop Interacts with the Hsp70 Chaperone in a Nucleotide-Dependent Fashion and Exhibits Ligand Selectivity.

    Directory of Open Access Journals (Sweden)

    Tawanda Zininga

    Full Text Available Heat shock proteins (Hsps play an important role in the development and pathogenicity of malaria parasites. One of the most prominent functions of Hsps is to facilitate the folding of other proteins. Hsps are thought to play a crucial role when malaria parasites invade their host cells and during their subsequent development in hepatocytes and red blood cells. It is thought that Hsps maintain proteostasis under the unfavourable conditions that malaria parasites encounter in the host environment. Although heat shock protein 70 (Hsp70 is capable of independent folding of some proteins, its functional cooperation with heat shock protein 90 (Hsp90 facilitates folding of some proteins such as kinases and steroid hormone receptors into their fully functional forms. The cooperation of Hsp70 and Hsp90 occurs through an adaptor protein called Hsp70-Hsp90 organising protein (Hop. We previously characterised the Hop protein from Plasmodium falciparum (PfHop. We observed that the protein co-localised with the cytosol-localised chaperones, PfHsp70-1 and PfHsp90 at the blood stages of the malaria parasite. In the current study, we demonstrated that PfHop is a stress-inducible protein. We further explored the direct interaction between PfHop and PfHsp70-1 using far Western and surface plasmon resonance (SPR analyses. The interaction of the two proteins was further validated by co-immunoprecipitation studies. We observed that PfHop and PfHsp70-1 associate in the absence and presence of either ATP or ADP. However, ADP appears to promote the association of the two proteins better than ATP. In addition, we investigated the specific interaction between PfHop TPR subdomains and PfHsp70-1/ PfHsp90, using a split-GFP approach. This method allowed us to observe that TPR1 and TPR2B subdomains of PfHop bind preferentially to the C-terminus of PfHsp70-1 compared to PfHsp90. Conversely, the TPR2A motif preferentially interacted with the C-terminus of PfHsp90. Finally, we

  1. [A place in the macrocosmos: Paracelsus in Bad Pfäfers].

    Science.gov (United States)

    Pörksen, G

    1994-03-29

    The script about Bad Pfäfers is an exception within the entire work of Paracelsus: It is short, completely worked over and has been printed already during his lifetime. It contains an unique list of comments on latin termini in his native language, hints about the context of their origin and may be read like a concentrate of his philosophy. Biography and personality of Paracelsus are briefly outlined; thereafter, the dark preface of the script on Bad Pfäfers is commented on. The latter turned out to be a stenograph of his central ideas on natural philosophy and cosmology as expressed in other scripts of the thirties, in the 'Astronomia magna' in particular (1536). The concept of the human body, of his macrocosmic derivation and of the 'source' as natural testimony of the healing nature of Christ becomes clear. Finally, from circumstantial evidence in text and context of the script, it is concluded, that it must have derived from the dialogue with the personnel of the spa uneducated in a humanistic sense, and may be understood as an abbreviated draft ("aide-mémoire") of Paracelsic instructions.

  2. Pf1 bacteriophage hydration by magic angle spinning solid-state NMR

    Energy Technology Data Exchange (ETDEWEB)

    Sergeyev, Ivan V.; Bahri, Salima; McDermott, Ann E., E-mail: aem5@columbia.edu [Department of Chemistry, Columbia University, 3000 Broadway, New York, New York 10027 (United States); Day, Loren A. [Public Health Research Institute, Rutgers University, 225 Warren St., Newark, New Jersey 07103 (United States)

    2014-12-14

    High resolution two- and three-dimensional heteronuclear correlation spectroscopy ({sup 1}H–{sup 13}C, {sup 1}H–{sup 15}N, and {sup 1}H–{sup 13}C–{sup 13}C HETCOR) has provided a detailed characterization of the internal and external hydration water of the Pf1 virion. This long and slender virion (2000 nm × 7 nm) contains highly stretched DNA within a capsid of small protein subunits, each only 46 amino acid residues. HETCOR cross-peaks have been unambiguously assigned to 25 amino acids, including most external residues 1–21 as well as residues 39–40 and 43–46 deep inside the virion. In addition, the deoxyribose rings of the DNA near the virion axis are in contact with water. The sets of cross-peaks to the DNA and to all 25 amino acid residues were from the same hydration water {sup 1}H resonance; some of the assigned residues do not have exchangeable side-chain protons. A mapping of the contacts onto structural models indicates the presence of water “tunnels” through a highly hydrophobic region of the capsid. The present results significantly extend and modify results from a lower resolution study, and yield a comprehensive hydration surface map of Pf1. In addition, the internal water could be distinguished from external hydration water by means of paramagnetic relaxation enhancement. The internal water population may serve as a conveniently localized magnetization reservoir for structural studies.

  3. Tumor p-glycoprotein correlates with efficacy of PF-3758309 in in vitro and in vivo models of colorectal cancer.

    Directory of Open Access Journals (Sweden)

    Erica Lynn Bradshaw-Pierce

    2013-03-01

    Full Text Available P-glycoprotein (P-gp, a member of the ATP-binding cassette transporter family, is overexpressed in a number of different cancers and some studies show that P-gp overexpression can be correlated to poor prognosis or therapeutic resistance. Here we sought to elucidate if PF-3758309 (PF-309, a novel p-21 activated kinase inhibitor, efficacy was influenced by tumor P-gp. Based on in vitro proliferation data, a panel of colorectal cancer cell lines were ranked as sensitive or resistant and ABCB1 (P-gp expression was evaluated by microarray for these cell lines. P-gp expression was determined by western blot and activity determined by rhodamine efflux assay. Knock down of P-gp and pharmacologic inhibition of P-gp to restore PF-309 activity was performed in vitro. PF-309 activity was evaluated in vivo in cell line xenograft models and in primary patient derived tumor xenografts (PDTX. Mice were treated with 25 mg/kg PF-309 orally, twice daily. On the last day of treatment, tumor and plasma were collected for PF-309 analysis. Here we show that ABCB1 gene expression correlates with resistance to PF-309 treatment in vitro and the expression and activity of P-gp was verified in a panel of resistant cells. Furthermore, inhibition of P-gp increased the sensitivity of resistant cells, resulting in a 4-100 fold decrease in the IC50s. Eleven cell line xenografts and 12 PDTX models were treated with PF-309. From the cell line xenografts, we found a significant correlation between ABCB1 gene expression profiles and tumor response. We evaluated tumor and plasma concentrations for 8 tumor models (3 cell line xenografts and 5 PDTX models and a significant correlation was found between tumor concentration and response. Additionally, we show that tumor concentration is approximately 4-fold lower in tumors that express P-gp, verified by western blot. Our in vitro and in vivo data strongly suggests that PF-309 efficacy is influenced by the expression of tumor P-gp.

  4. French electric power balance sheet 2009

    International Nuclear Information System (INIS)

    Lartigau, Thierry; Riere, Alexia

    2010-01-01

    The mission of RTE, the French electricity Transportation grid, a public service assignment, is to balance the electricity supply and demand in real time. This report presents RTE's technical results for the year 2009: key figures of the French electricity consumption, lowering of the French power generation, decrease of trade balance at borders but still positive, continuation of RTE's investments for the improvement of the grid performance. New RTE's infrastructures, electricity quality data, and the evolution of market mechanisms are presented in appendixes

  5. Foreign direct investments into French real estate

    OpenAIRE

    BRIZARD, Arthur

    2013-01-01

    The purpose of this thesis is to draw the global trend of Foreign Direct Investments (FDI) in the French real estate market since 2008 and to understand foreign investors’ behavior and the incentives which urge them to invest in French property market. This study relies on the numerous yearly reports released by consulting and real estate companies and gives an overview of FDI since 2008. From a legal point of view, the French property market is extremely organized. Acquiring, holding and sel...

  6. Surface chemistry of PH 3, PF 3 and PCl 3 on Ru(0001)

    Science.gov (United States)

    Tao, H.-S.; Diebold, U.; Shinn, N. D.; Madey, T. E.

    1994-06-01

    The adsorption, desorption and decomposition of PH 3, PF 3 and PCl 3 on Ru(0001) have been studied by soft X-ray photoelectron spectroscopy (SXPS) using synchrotron radiation. Due to large chemical shifts in the P 2p core levels, different phosphorus containing surface species can be identified. We find that PF 3 adsorbs molecularly on Ru(0001) at 80 and 300 K. At 80 K, PH 3 saturates the surface with one layer of atomic hydrogen, elemental phosphorus, subhydride (i.e., PHx (0 PH 3, with a total phosphorus coverage of 0.4 ML. At 300 K, PH 3 decomposes into atomic hydrogen and elemental phosphorus with a phosphorus coverage of 0.8 ML. At 80 K, PCl 3 adsorbs dissociatively into atomic chlorine, elemental phosphorus, PCl and possibly PCl 2 and PCl 3 in the first monolayer. Formation of multilayers of PCl 3 is observed at 80 K. At 300 K, PCl 3 adsorbs dissociatively as atomic chlorine and elemental phosphorus with a saturation phosphorus coverage of 0.1 ML. The variation in total phosphorus uptake at 300 K from PX3 ( X = H, FandCl) adsorption is a result of competition between site blocking by dissociation fragments and displacement reactions. Annealing surfaces with adsorbed phosphorus to 1000 K results in formation of RuzP ( z = 1 or 2), which is manifested by the chemical shifts in the P2p core level, as well as the P LVV Auger transition. The recombination of adsorbed phosphorus and adsorbed X ( = H, FandCl) from decomposition is also observed, but is a minor reaction channel on the surface. Thermochemical data are used to analyze the different stabilities of PX 3 at 300 K, namely, PF 3 adsorbs molecularly and PH 3 and PCl 3 dissociate completely. First, we compare the heat of molecular adsorption and the heat of dissociative adsorption of PX 3 on Ru(0001), using an enthalpy approach, and find results consistent with experimental observations. Second, we compare the total bond energy difference between molecular adsorption and complete dissociation of PX 3 on Ru

  7. Memory decline in Down syndrome and its relationship to iPF2alpha, a urinary marker of oxidative stress.

    Directory of Open Access Journals (Sweden)

    Panagiotis Zis

    Full Text Available Lipid peroxidation may be a marker of free-radical-mediated injury associated with Alzheimer's disease (AD. We aimed to investigate whether changes in lipid peroxidation is associated with cognitive decline in individuals with Down syndrome over a 4-year period.Thirty-two adults with DS participated in a longitudinal study with urinary isoprostane 8,12-iso-iPF2alpha (iPF2alpha assays at baseline and four years follow-up. Informants rated their functional ability and memory function and the adults with DS attempted assessments of language skills and memory. Twenty-six individuals completed assessments of memory (Modified Memory Object Task, MOMT, adaptive behavior (ABAS, and receptive vocabulary (British Picture vocabulary, BPVS at both time-points.Overall change in iPF2alpha level was negatively correlated with change in the MOMT score (Spearman's Rho =  -0.576, p = 0.006, i.e., increased lipid peroxidation was correlated with worse memory functioning over time. An increase of ≥ 0.02 ng/mg creatinine iPF2α had good sensitivity (85.7%, positive predictive value (75%,, specificity (85.7% and negative predictive value (92.3% for memory decline.Change in iPF2alpha over time may have potential as a biomarker for memory decline in Down syndrome and potentially also help to track progression of MCI to AD in the general population.

  8. Molecular interaction of selected phytochemicals under the charged environment of Plasmodium falciparum chloroquine resistance transporter (PfCRT) model.

    Science.gov (United States)

    Patel, Saumya K; Khedkar, Vijay M; Jha, Prakash C; Jasrai, Yogesh T; Pandya, Himanshu A; George, Linz-Buoy; Highland, Hyacinth N; Skelton, Adam A

    2016-01-01

    Phytochemicals of Catharanthus roseus Linn. and Tylophora indica have been known for their inhibition of malarial parasite, Plasmodium falciparum in cell culture. Resistance to chloroquine (CQ), a widely used antimalarial drug, is due to the CQ resistance transporter (CRT) system. The present study deals with computational modeling of Plasmodium falciparum chloroquine resistance transporter (PfCRT) protein and development of charged environment to mimic a condition of resistance. The model of PfCRT was developed using Protein homology/analogy engine (PHYRE ver 0.2) and was validated based on the results obtained using PSI-PRED. Subsequently, molecular interactions of selected phytochemicals extracted from C. roseus Linn. and T. indica were studied using multiple-iterated genetic algorithm-based docking protocol in order to investigate the translocation of these legends across the PfCRT protein. Further, molecular dynamics studies exhibiting interaction energy estimates of these compounds within the active site of the protein showed that compounds are more selective toward PfCRT. Clusters of conformations with the free energy of binding were estimated which clearly demonstrated the potential channel and by this means the translocation across the PfCRT is anticipated.

  9. The ALK inhibitor PF-06463922 is effective as a single agent in neuroblastoma driven by expression of ALK and MYCN

    Directory of Open Access Journals (Sweden)

    J. Guan

    2016-09-01

    Full Text Available The first-in-class inhibitor of ALK, c-MET and ROS1, crizotinib (Xalkori, has shown remarkable clinical efficacy in treatment of ALK-positive non-small cell lung cancer. However, in neuroblastoma, activating mutations in the ALK kinase domain are typically refractory to crizotinib treatment, highlighting the need for more potent inhibitors. The next-generation ALK inhibitor PF-06463922 is predicted to exhibit increased affinity for ALK mutants prevalent in neuroblastoma. We examined PF-06463922 activity in ALK-driven neuroblastoma models in vitro and in vivo. In vitro kinase assays and cell-based experiments examining ALK mutations of increasing potency show that PF-06463922 is an effective inhibitor of ALK with greater activity towards ALK neuroblastoma mutants. In contrast to crizotinib, single agent administration of PF-06463922 caused dramatic tumor inhibition in both subcutaneous and orthotopic xenografts as well as a mouse model of high-risk neuroblastoma driven by Th-ALKF1174L/MYCN. Taken together, our results suggest PF-06463922 is a potent inhibitor of crizotinib-resistant ALK mutations, and highlights an important new treatment option for neuroblastoma patients.

  10. Biochemical responses and DNA damage in earthworms (Eisenia fetida) induced by ionic liquid [omim]PF6.

    Science.gov (United States)

    Liu, Xiaoyan; Zhang, Shumin; Wang, Jinhua; Wang, Jun; Shao, Yuting; Zhu, Lusheng

    2016-04-01

    Ionic liquids that are not that "green" to many organisms have recently been identified. This study examined the subchronic toxicity of the ionic liquid 1-octyl-3-methylimidazolium hexafluorophosphate ([omim]PF6) to earthworms (Eisenia fetida). Earthworms were exposed for a 28-day period (sampled on days 7, 14, 21, and 28) at concentrations of 0, 5, 10, 20, and 40 mg/kg. The levels of reactive oxygen species (ROS), antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), guaiacol peroxidase (POD)), detoxifying enzyme (glutathione S-transferase (GST)), lipid peroxidation, and DNA damage were measured. ROS significantly accumulated in all the treatment groups; the maximum ROS content was 51.9% higher than the control at 40 mg/kg [omim]PF6 on day 28. Increased SOD activities attenuated over the time of exposure, while the CAT activities of the treatment groups were similar to the controls, except on day 14. Furthermore, the activities of POD and GST were stimulated. Lipid peroxidation in earthworms was not apparent at 5 and 10 mg/kg [omim]PF6 but was quite obvious at 40 mg/kg [omim]PF6. In addition, DNA damage was dose- and time-dependent. In conclusion, [omim]PF6 caused oxidative stress and genotoxicity in earthworms.

  11. Radio cobalt in French rivers

    International Nuclear Information System (INIS)

    Lambrechts, A.; Baudin-Jaulent, Y.

    1996-01-01

    The isotopes 58 and 60 of cobalt present in liquid wastes from nuclear plants or from fuel reprocessing plant of Marcoule are fixed in the different compartments of French rivers. The activity levels of radio-cobalt vary according to the sampled compartments nature (bryophyta > immersed plants > sediment > fish). Elsewhere, laboratory experimentations show that the contamination of fish occurs essentially from the water way rather than from food. Cobalt is mainly fixed by kidneys; muscles is no more than 30 % of the total fish activity. (author)

  12. French programme for HTR fuel

    International Nuclear Information System (INIS)

    Gillet, R.M.

    1991-01-01

    It is reported that in the frameworks of the French HTR research program, stopped in 1979 the HTR coated particle fuel, fuel rod and prismatic fuel element design have been successfully developed and irradiation tested in France and specific examination methods for irradiated fuel particles, rods and graphite blocks have been developed. Currently CEA is involved in fission product transport experiments sponsored by the US Department of Energy and performed in the COMEDIE loop. Finally the CEA follows progress and developments in HTR fuel research and development throughout the world. 1 tab

  13. Future perspectives of French dissuasion

    International Nuclear Information System (INIS)

    Duval M.

    1996-01-01

    If the French deterrence must disappear in aid of an European deterrence, it will be necessary to take in account the development of nuclear weapon in Asia and then our deterrence system should maintain its credibility by getting the appropriate length. If policy problems are as important for civil nuclear than for military nuclear, it will be necessary to show concern about them because the Asian economy is in full development and Asia is not so frightened by nuclear power than Europe. (N.C.)

  14. French regulations and waste management

    International Nuclear Information System (INIS)

    Sousselier, Y.

    1985-01-01

    The authors describe the organization and the role of safety authorities in France in matter of waste management. They precise the French policy in waste storage and treatment: basic objectives, optimization of waste management. The safety requirements are based upon the barrier principle. Safety requirements about waste conditioning and waste disposal are mentioned. In addition to the safety analysis and studies described above, the Protection and Nuclear Safety Institute assists the ministerial authorities in the drafting of ''basic safety rules (RFS)'', laying down safety objectives. Appendix 1 and Appendix 2 deal with safety aspects in spent fuel storage and in transportation of radioactive materials [fr

  15. French uranium mining sites remediation

    International Nuclear Information System (INIS)

    Roche, M.

    2002-01-01

    Following a presentation of the COGEMA's general policy for the remediation of uranium mining sites and the regulatory requirements, the current phases of site remediation operations are described. Specific operations for underground mines, open pits, milling facilities and confining the milled residues to meet long term public health concerns are detailed and discussed in relation to the communication strategies to show and explain the actions of COGEMA. A brief review of the current remediation situation at the various French facilities is finally presented. (author)

  16. The Hidden Lincoln in French Opinion

    Directory of Open Access Journals (Sweden)

    Jacques Portes

    2016-05-01

    Full Text Available Abraham Lincoln has never served as a model for French politicians. He was indeed compared to Carnot, the organizer of the French Revolutionary wars. But when Clemenceau led France in WWI, when De Gaulle stood for France’s independence in WWII, nobody thought of comparing them to Lincoln. This essay analyzes French public opinion during the American Civil War with a focus on Lincoln, based on a study of the few French books published between 1860 and 1865 on the US, diaries, a sample of conservative and republican daily papers, weekly reviews and illustrated newspapers.

  17. Colloquial French the complete course for beginners

    CERN Document Server

    Demouy, Valérie

    2015-01-01

    Colloquial French: The Complete Course for Beginners has been carefully developed by an experienced teacher to provide a step-by-step course to French as it is written and spoken today. Combining a clear, practical and accessible style with a methodical and thorough treatment of the language, it equips learners with the essential skills needed to communicate confidently and effectively in French in a broad range of situations. No prior knowledge of the language is required. Colloquial French is exceptional; each unit presents a wealth of grammatical points that are reinforced with a wide range

  18. Crisis in the French nuclear industry

    International Nuclear Information System (INIS)

    Nectoux, F.

    1991-02-01

    This report discusses the economics of the French nuclear power industry. It considers the dominant position of nuclear power in the French energy system, stresses the scale and causes of the current (1990) economic crisis and dispels the popular misconceptions on the cost efficiency of the French programme. The evidence is based on widely available French documents and articles. The report begins by looking at the background of nuclear power in France then discusses the problem of overcapacity, the technical problems and fall in load factors, generating costs and electricity prices and finally, strategic issues are considered. (UK)

  19. Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism

    International Nuclear Information System (INIS)

    Chiu, Hsiu-Ju; Bakolitsa, Constantina; Skerra, Arne; Lomize, Andrei; Carlton, Dennis; Miller, Mitchell D.; Krishna, S. Sri; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L.; Clayton, Thomas; Deller, Marc C.; Duan, Lian; Feuerhelm, Julie; Grant, Joanna C.; Grzechnik, Slawomir K.; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Kozbial, Piotr; Kumar, Abhinav; Marciano, David; McMullan, Daniel; Morse, Andrew T.; Nigoghossian, Edward; Okach, Linda; Paulsen, Jessica; Reyes, Ron; Rife, Christopher L.; Bedem, Henry van den; Weekes, Dana; Xu, Qingping; Hodgson, Keith O.; Wooley, John; Elsliger, Marc-André; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A.

    2009-01-01

    NE1406, the first structural representative of PF09410, reveals a lipocalin-like fold with features that suggest involvement in lipid metabolism. In addition, NE1406 provides potential structural templates for two other protein families (PF07143 and PF08622). The first structural representative of the domain of unknown function DUF2006 family, also known as Pfam family PF09410, comprises a lipocalin-like fold with domain duplication. The finding of the calycin signature in the N-terminal domain, combined with remote sequence similarity to two other protein families (PF07143 and PF08622) implicated in isoprenoid metabolism and the oxidative stress response, support an involvement in lipid metabolism. Clusters of conserved residues that interact with ligand mimetics suggest that the binding and regulation sites map to the N-terminal domain and to the interdomain interface, respectively

  20. French high level wastes management

    International Nuclear Information System (INIS)

    Gauvenet, A.J.; Sombret, C.G.

    1980-06-01

    The first French spent fuel reprocessing plant went on stream in 1956 at Marcoule. Since then, all French irradiated fuels and some foreign spent fuels have been reprocessed either in this plant or in a subsequent plant built at La Hague. Marcoule is primarily devoted to metallic fuels, and La Hague to oxide fuels. The fission products solutions generated by reprocessing are acid liquids. They are stored on site in double walled stainless steel tanks fitted with a cooling device to deal with thermal release due to radioactive decay. Although these liquids are retrievable and can be transfered from one tank to another, and in spite of the fact that no disturbance such as overheating or leakage has ever occurred, a decision was made to solidify these solutions in order to make interim storage and, later on, ultimate disposal, safer and easier to control. Glass was chosen, because it is a flexible medium to deal with and it answers the quality requirements of ultimate disposal as well as the manufacturing constraints, such as equipment corrosion, volatilization during fabrication, and suitability to casting into canisters

  1. Murder in French criminal law

    Directory of Open Access Journals (Sweden)

    Jovašević Dragan

    2015-01-01

    Full Text Available The most dangerous forms and aspects of violent crime are criminal offences against life and bodily integrity of others, which are generally designated as acts of homicide. The most prominent among these criminal offences is the crime of murder. Due to the significance, legal nature, characteristics and consequences of this criminal act, all contemporary legislations prescribe the most severe measures and types of punishment for the commission of this crime. There are three types of murder: 1 ordinary (common murder, 2 murder committed under mitigating circumstances, and 3 murder committed under aggravating circumstances, which is as a rule punishable by the most severe punishment. All contemporary criminal legislations, including French legislation, recognize various types and forms of murder, depending on the classification criteria. The most prominent forms of murder are those involving various motives that induce the perpetrators to cause death to another person. In this paper, the author examines the concept, contents, characteristics, forms and elements of the crime of murder in French criminal law, discussing the theoretical and practical aspects of this issue.

  2. Numerical estimation on balance coefficients of central difference averaging method for quench detection of the KSTAR PF coils

    International Nuclear Information System (INIS)

    Kim, Jin Sub; An, Seok Chan; Ko, Tae Kuk; Chu, Yong

    2016-01-01

    A quench detection system of KSTAR Poloidal Field (PF) coils is inevitable for stable operation because normal zone generates overheating during quench occurrence. Recently, new voltage quench detection method, combination of Central Difference Averaging (CDA) and Mutual Inductance Compensation (MIK) for compensating mutual inductive voltage more effectively than conventional voltage detection method, has been suggested and studied. For better performance of mutual induction cancellation by adjacent coils of CDA+MIK method for KSTAR coil system, balance coefficients of CDA must be estimated and adjusted preferentially. In this paper, the balance coefficients of CDA for KSTAR PF coils were numerically estimated. The estimated result was adopted and tested by using simulation. The CDA method adopting balance coefficients effectively eliminated mutual inductive voltage, and also it is expected to improve performance of CDA+MIK method for quench detection of KSTAR PF coils

  3. The Malarial Exported PFA0660w Is an Hsp40 Co-Chaperone of PfHsp70-x.

    Directory of Open Access Journals (Sweden)

    Michael O Daniyan

    Full Text Available Plasmodium falciparum, the human pathogen responsible for the most dangerous malaria infection, survives and develops in mature erythrocytes through the export of proteins needed for remodelling of the host cell. Molecular chaperones of the heat shock protein (Hsp family are prominent members of the exportome, including a number of Hsp40s and a Hsp70. PFA0660w, a type II Hsp40, has been shown to be exported and possibly form a complex with PfHsp70-x in the infected erythrocyte cytosol. However, the chaperone properties of PFA0660w and its interaction with human and parasite Hsp70s are yet to be investigated. Recombinant PFA0660w was found to exist as a monomer in solution, and was able to significantly stimulate the ATPase activity of PfHsp70-x but not that of a second plasmodial Hsp70 (PfHsp70-1 or a human Hsp70 (HSPA1A, indicating a potential specific functional partnership with PfHsp70-x. Protein binding studies in the presence and absence of ATP suggested that the interaction of PFA0660w with PfHsp70-x most likely represented a co-chaperone/chaperone interaction. Also, PFA0660w alone produced a concentration-dependent suppression of rhodanese aggregation, demonstrating its chaperone properties. Overall, we have provided the first biochemical evidence for the possible role of PFA0660w as a chaperone and as co-chaperone of PfHsp70-x. We propose that these chaperones boost the chaperone power of the infected erythrocyte, enabling successful protein trafficking and folding, and thereby making a fundamental contribution to the pathology of malaria.

  4. PF2fit: Polar Fast Fourier Matched Alignment of Atomistic Structures with 3D Electron Microscopy Maps.

    Directory of Open Access Journals (Sweden)

    Radhakrishna Bettadapura

    2015-10-01

    Full Text Available There continue to be increasing occurrences of both atomistic structure models in the PDB (possibly reconstructed from X-ray diffraction or NMR data, and 3D reconstructed cryo-electron microscopy (3D EM maps (albeit at coarser resolution of the same or homologous molecule or molecular assembly, deposited in the EMDB. To obtain the best possible structural model of the molecule at the best achievable resolution, and without any missing gaps, one typically aligns (match and fits the atomistic structure model with the 3D EM map. We discuss a new algorithm and generalized framework, named PF(2 fit (Polar Fast Fourier Fitting for the best possible structural alignment of atomistic structures with 3D EM. While PF(2 fit enables only a rigid, six dimensional (6D alignment method, it augments prior work on 6D X-ray structure and 3D EM alignment in multiple ways: Scoring. PF(2 fit includes a new scoring scheme that, in addition to rewarding overlaps between the volumes occupied by the atomistic structure and 3D EM map, rewards overlaps between the volumes complementary to them. We quantitatively demonstrate how this new complementary scoring scheme improves upon existing approaches. PF(2 fit also includes two scoring functions, the non-uniform exterior penalty and the skeleton-secondary structure score, and implements the scattering potential score as an alternative to traditional Gaussian blurring. Search. PF(2 fit utilizes a fast polar Fourier search scheme, whose main advantage is the ability to search over uniformly and adaptively sampled subsets of the space of rigid-body motions. PF(2 fit also implements a new reranking search and scoring methodology that considerably improves alignment metrics in results obtained from the initial search.

  5. The patellofemoral pain and osteoarthritis subscale of the KOOS (KOOS-PF): development and validation using the COSMIN checklist.

    Science.gov (United States)

    Crossley, Kay M; Macri, Erin M; Cowan, Sallie M; Collins, Natalie J; Roos, Ewa M

    2017-03-03

    Patellofemoral pain and osteoarthritis are prevalent and associated with substantial pain and functional impairments. Patient-reported outcome measures (PROMs) are recommended for research and clinical use, but no PROMs are specific for patellofemoral osteoarthritis, and existing PROMs for patellofemoral pain have methodological limitations. This study aimed to develop a new subscale of the Knee injury and Osteoarthritis Outcome Score for patellofemoral pain and osteoarthritis (KOOS-PF), and evaluate its measurement properties. Items were generated using input from 50 patients with patellofemoral pain and/or osteoarthritis and 14 health and medical clinicians. Item reduction was performed using data from patellofemoral cohorts (n=138). We used the COnsesus-based Standards for the selection of health Measurements INstruments guidelines to evaluate reliability, validity, responsiveness and interpretability of the final version of KOOS-PF and other KOOS subscales. From an initial 80 generated items, the final subscale included 11 items. KOOS-PF items loaded predominantly on one factor, pain during activities that load the patellofemoral joint. KOOS-PF had good internal consistency (Cronbach's α 0.86) and adequate test-retest reliability (intraclass correlation coefficient 0.86). Hypothesis testing supported convergent, divergent and known-groups validity. Responsiveness was confirmed, with KOOS-PF demonstrating a moderate correlation with Global Rating of Change scores (r 0.52) and large effect size (Cohen's d 0.89). Minimal detectable change was 2.3 (groups) and 16 (individuals), while minimal important change was 16.4. There were no floor or ceiling effects. The 11-item KOOS-PF, developed in consultation with patients and clinicians, demonstrated adequate measurement properties, and is recommended for clinical and research use in patients with patellofemoral pain and osteoarthritis. © Article author(s) (or their employer(s) unless otherwise stated in the text of

  6. Electrochemical studies of UO22+ in 1-octyl 3- methylimidazolium hexafluorophosphate (omimPF6) room temperature ionic liquid

    International Nuclear Information System (INIS)

    Kamat, J.V.; Gopinath, N.; Lohithakshan, K.V.; Aggarwal, S.K.

    2007-01-01

    The effect of the degraded products on the Electrochemical Window (EW) of l-octyl 3- methylimidazolium hexafluorophosphate (OmimPF 6 ) were studied. Studies were also carried to optimize conditions for extraction of UO 2 2+ to investigate its redox behavior in OmimPF6 and determine the number of electrons involved in the redox chemistry. The Chronoamperometric technique of evaluating n without knowing diffusion coefficient, D, was devised by Kakihana et al. and has been applied in the present work. The number of electrons involved was determined from the values of slope and intercept of the Cottrell plot. The results of these studies are presented in this paper

  7. MHD equilibrium methods for ITER [International Thermonuclear Experimental Reactor] PF [poloidal field] coil design and systems analysis

    International Nuclear Information System (INIS)

    Strickler, D.J.; Galambos, J.D.; Peng, Y.K.M.

    1989-03-01

    Two versions of the Fusion Engineering Design Center (FEDC) free-boundary equilibrium code designed to computer the poloidal field (PF) coil current distribution of elongated, magnetically limited tokamak plasmas are demonstrated and applied to the systems analysis of the impact of plasma elongation on the design point of the International Thermonuclear Experimental Reactor (ITER). These notes were presented at the ITER Specialists' Meeting on the PF Coil System and Operational Scenario, held at the Max Planck Institute for Plasma Physics in Garching, Federal Republic of Germany, May 24--27, 1988. 8 refs., 6 figs., 4 tabs

  8. TRAC-PF1 MOD1 post test calculations of the OECD LOFT Experiment LP-SB-1

    International Nuclear Information System (INIS)

    Allen, E.J.

    1990-04-01

    Analysis of the small, hot leg break, OECD LOFT Experiment LP-SB-1. using the ''best-estimate'' computer code TRAC-PF1/MOD1 is presented. Descriptions of the LOFT facility and the LP-SB-1 experiment are given and development of the TRAC-PF1/MOD1 input model is detailed. The calculations performed in achieving the steady state conditions, from which the experiment was initiated, and the specification of experimental boundary conditions are outlined. 24 refs., 66 figs., 12 tabs

  9. Tumor P-Glycoprotein Correlates with Efficacy of PF-3758309 in in vitro and in vivo Models of Colorectal Cancer

    OpenAIRE

    Bradshaw-Pierce, Erica Lynn; Pitts, Todd M.; Tan, Aik-Choon; McPhillips, Kelly; West, Mark; Gustafson, Daniel L.; Halsey, Charles; Nguyen, Leslie; Lee, Nathan V.; Kan, Julie L. C.; Murray, Brion William; Eckhardt, S. Gail

    2013-01-01

    P-glycoprotein (P-gp), a member of the ATP-binding cassette transporter family, is overexpressed in a number of different cancers and some studies show that P-gp overexpression can be correlated to poor prognosis or therapeutic resistance. Here we sought to elucidate if PF-3758309 (PF-309), a novel p-21 activated kinase inhibitor, efficacy was influenced by tumor P-gp. Based on in vitro proliferation data, a panel of colorectal cancer cell lines were ranked as sensitive or resistant and ABCB1...

  10. Tumor p-glycoprotein correlates with efficacy of PF-3758309 in in vitro and in vivo models of colorectal cancer.

    OpenAIRE

    Erica Lynn Bradshaw-Pierce; Erica Lynn Bradshaw-Pierce; Todd M Pitts; Aik-Choon eTan; Kelly eMcPhillips; Mark eWest; Daniel L Gustafson; Charles eHalsey; Leslie eNguyen; Nathan V Lee; Julie LC Kan; Brion William Murray; S. Gail eEckhardt

    2013-01-01

    P-glycoprotein (P-gp), a member of the ATP-binding cassette transporter family, is overexpressed in a number of different cancers and some studies show that P-gp overexpression can be correlated to poor prognosis or therapeutic resistance. Here we sought to elucidate if PF-3758309 (PF-309), a novel p-21 activated kinase inhibitor, efficacy was influenced by tumor P-gp. Based on in vitro proliferation data, a panel of colorectal cancer cell lines were ranked as sensitive or resistant and ABCB...

  11. The absent father of Sino-French cinema: Contemporary Taiwanese cinema and 1950s French auteurs

    OpenAIRE

    Bloom, ME

    2014-01-01

    © 2014 Taylor & Francis. In contemporary Sino-French cinema, father characters who are dead, long lost or geographically distant leave gaping holes in the lives of the offspring left behind. The absent fathers in Sino-French films by Taiwanese auteurs Cheng Yu-chieh, Hou Hsiao-hsien and Tsai Ming-liang serve as metaphors for French auteurs. French New Wave films constitute the majority of the intertexts; however, early 1950s French cinema and even late nineteenth-century painting reflect th...

  12. Reading Speed of Contracted French Braille

    Science.gov (United States)

    Laroche, Louise; Boule, Jacinthe; Wittich, Walter

    2012-01-01

    This study was designed to address three hypotheses: (1) The reading speed of both readers of French braille and readers of French print will be faster in the silent condition; however, this gain in speed will be larger for print readers; (2) Individuals who acquired braille before age 10 will display faster reading speeds at lower error rates…

  13. Gabonese French Dictionaries: Survey and Perspectives*

    African Journals Online (AJOL)

    Gabonese French Dictionaries: Survey and Perspectives. 257 ... be regarded, according to Gouws (2007: 314), as externally motivated products. .... Fair attention is given to different style or normative levels, i.e. .... differs enough from standard French to be regarded as a new emerging lan- ..... Tous les leaders des par-.

  14. French Romanticism and Napoleon's "Geometric Men."

    Science.gov (United States)

    Cole, Robert A.

    1982-01-01

    French intellectual thought changed during the Napoleonic Era. The effects of the Enlightenment philosophers, the French Revolution, the Industrial Revolution, and Romanticism on the development of Napoleon's philosophical outlook are used to illustrate the changes occurring in France as a whole in the early nineteenth century. (AM)

  15. French Phonology for Teachers: A Programmed Introduction.

    Science.gov (United States)

    Green, Jerald R.; Poulin, Norman A.

    This programed, self-instructional course has the following terminal objectives: (1) to present some notions of the science of linguistics and the major branches of linguistics, (2) to teach the segmental and suprasegmental phonemes of French, (3) to identify the major articulatory problems of French for the native speaker of English, (4) to…

  16. The French Regions and Their Social Health

    Science.gov (United States)

    Jany-Catrice, Florence

    2009-01-01

    In this article, a new indicator designed to capture the multidimensionality of the social health of the French regions is put to the test. Drawing on regional data for 2004, this indicator of social health (ISH) sheds new light on the social performance of the French regions. The worst performers are the highly urbanised regions, whereas others,…

  17. French for Specific Purposes: The Hawaiian Experience.

    Science.gov (United States)

    Benouis, Mustapha

    1986-01-01

    Describes the development of and the reaction to a course in Business French at the University of Hawaii. Its success, coupled with its recognition by state and academic officials, brought about the initiation of similar courses in other languages and the development of French for travel industry management majors. (SED)

  18. French Higher Education: A Cartoon Essay

    Science.gov (United States)

    Hall, Matthew Henry

    2012-01-01

    In this cartoon essay, the author shares his experience from a travel to Paris to see the French higher education system. From his travel, he learned that in France, "degree" inflation may be an issue, but not grade inflation. On the flight home, the author reflects how French and American academics answer one question about the state of…

  19. The French Language in the Americas.

    Science.gov (United States)

    Valdman, Albert, Ed.

    The annual bulletin of the French 8 section of the Annual Meeting of the Modern Language Association of America is presented with the texts of papers read at both the 1969 and 1970 sessions. The 1970 papers, in French, include Jean Louis Darbelnet's "Etude Sociolinguistique des contacts entre 1'Anglais et le Francais au Canada et en…

  20. French Military Adaptation in the Afghan War

    DEFF Research Database (Denmark)

    Schmitt, Olivier

    2017-01-01

    as any to borrow from other countries’ experiences. In order to do so, this article introduces the concept of ‘selective emulation’, and compares the French and German military adaptation processes in Afghanistan. The article argues that there is indeed something distinctive about French military...

  1. French petroleum demand stable since thirteen years

    International Nuclear Information System (INIS)

    Chauvot, M.

    2005-01-01

    The French union of petroleum industries (Ufip) has presented a globally satisfactory status of the French petroleum situation. However, the refining capacities are not always well adapted to the evolution of the demand and the production of diesel fuels remains insufficient while France exports gasoline. Short paper. (J.S.)

  2. Health Information in French (français)

    Science.gov (United States)

    ... Biopsy - français (French) Bilingual PDF Health Information Translations Breast Biopsy - français (French) Bilingual PDF Health Information Translations Colposcopy - français (French) Bilingual PDF ...

  3. Valence shell photoionization energies and cross-sections of NF sub 3 and PF sub 3

    CERN Document Server

    Jürgensen, A

    2003-01-01

    Relative outer valence shell ionization potentials and cross-sections were determined for the isostructural, Group 15, trifluorides NF sub 3 and PF sub 3 in the gas phase using synchrotron radiation. Excitation photon energies ranged from 70 to 160 eV. The experimental spectra were assigned and cross-sections analyzed with the aid of both MS-X alpha and ab initio calculations. Spectral differences in peak energies and relative intensities are related to structural and electronic differences between these two fluoride molecules. Valence shell ionization potentials were compared to calculated values obtained by several different methods. The partial photoionization cross-sections for each orbital were obtained as a function of excitation energy and compared to theoretical results obtained with the X alpha method.

  4. TRAC-PF1 code verification with data from the OTIS test facility

    International Nuclear Information System (INIS)

    Childerson, M.T.; Fujita, R.K.

    1985-01-01

    A computer code (TRAC-PF1/MOD1) developed for predicting transient thermal and hydraulic integral nuclear steam supply system (NSSS) response was benchmarked. Post-small break loss-of-coolant accident (LOCA) data from a scaled, experimental facility, designated the One-Through Integral System (OTIS), were obtained for the Babcock and Wilcox NSSS and compared to TRAC predictions. The OTIS tests provided a challenging small break LOCA data set for TRAC verification. The major phases of a small break LOCA observed in the OTIS tests included pressurizer draining and loop saturation, intermittent reactor coolant system circulation, boiler-condenser mode, and the initial stages of refill. The TRAC code was successful in predicting OTIS loop conditions (system pressures and temperatures) after modification of the steam generator model. In particular, the code predicted both pool and auxiliary-feedwater initiated boiler-condenser mode heat transfer

  5. Discovery of PF-04620110, a Potent, Selective, and Orally Bioavailable Inhibitor of DGAT-1.

    Science.gov (United States)

    Dow, Robert L; Li, Jian-Cheng; Pence, Michael P; Gibbs, E Michael; LaPerle, Jennifer L; Litchfield, John; Piotrowski, David W; Munchhof, Michael J; Manion, Tara B; Zavadoski, William J; Walker, Gregory S; McPherson, R Kirk; Tapley, Susan; Sugarman, Eliot; Guzman-Perez, Angel; DaSilva-Jardine, Paul

    2011-05-12

    Acyl-CoA:diacylglycerol acyltransferase-1 (DGAT-1) catalyzes the final committed step in the biosynthesis of triglycerides. DGAT-1 knockout mice have been shown to be resistant to diet-induced obesity and have increased insulin sensitivity. Thus, inhibition of DGAT-1 may represent an attractive target for the treatment of obesity or type II diabetes. Herein, we report the discovery and characterization of a potent and selective DGAT-1 inhibitor PF-04620110 (3). Compound 3 inhibits DGAT-1 with an IC50 of 19 nM and shows high selectivity versus a broad panel of off-target pharmacologic end points. In vivo DGAT-1 inhibition has been demonstrated through reduction of plasma triglyceride levels in rodents at doses of ≥0.1 mg/kg following a lipid challenge. On the basis of this pharmacologic and pharmacokinetic profile, compound 3 has been advanced to human clinical studies.

  6. Independent Review of Siesmic Performance Assessments for the Plutonium Facility PF-4

    Energy Technology Data Exchange (ETDEWEB)

    Whittaker, Andrew [State Univ. of New York (SUNY), Buffalo, NY (United States); Goen, Lawrence Kenneth [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Kennedy, Robert [RPK Structural Mechanics, San Diego, CA (United States); McDonald, Brian [Exponent, Los Angeles, CA (United States); Morgan, Troy [Exponent, Los Angeles, CA (United States); Wyllie, Loring [Degenkolb Engineers, San Francisco, CA (United States)

    2015-11-25

    The Plutonium Facility, designated PF-4, is located in Technical Area 55 at the Los Alamos National Laboratory (LANL). The facility is a one-story rectangular structure above a complete basement; the building was constructed of cast-in-place reinforced concrete, with small interior frames of structural steel. The plan dimensions of the building are 265’×284’. The overall height of the building varies between 39’-0” at the north and south ends, and 40’-6” at the center ridge. The programmatic work performed in the building is vital to our national security and its functions and storage purposes are not replicated elsewhere in the United States Department of Energy (DOE).

  7. Status of PF-ring commissioning after the reconstruction for the straight-sections upgrade

    International Nuclear Information System (INIS)

    Tanimoto, Yasunori; Miyauchi, Hiroshi; Honda, Tohru; Kobayashi, Yukinori

    2006-01-01

    The upgrade project of the straight sections at the PF-ring enables the reinforcement of insertion devices and their beamlines. As a main part of this project, a large-scale reconstruction of the storage ring was carried out from March to September in 2005. The lattice configuration was modified to create short straight sections of 1.4 m and to extend the existing straight sections. Optical functions of the short sections were optimized for short-gap mini-pole undulators as X-ray sources. The first mini-pole undulator SGU no.17 has been operated for a protein crystallography. A recommissioning of the ring was conducted for about one month, and user experiments were restarted on 18th October 2005 according to schedule. The recovery of the beam lifetime due to the process of the vacuum scrubbing has been favorably progressed. (author)

  8. Met tyrosine kinase inhibitor, PF-2341066, suppresses growth and invasion of nasopharyngeal carcinoma

    Directory of Open Access Journals (Sweden)

    Zhao Y

    2015-08-01

    Full Text Available Yuanyuan Zhao,1,* Jing Zhang,2,* Ying Tian,1,* Cong Xue,1 Zhihuang Hu,1 Li Zhang1,3 1Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, and Collaborative Innovation Center for Cancer Medicine, 2Department of Medical Oncology, the First Affiliated Hospital of Guang Zhou Traditional Chinese Medicine University, 3National Anti-Cancer Drug Research Centre, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, and Collaborative Innovation Center for Cancer Medicine, Guangzhou, People’s Republic of China*These authors contributed equally to this work Purpose: We explored the effect of hepatocyte growth factor (HGF/Met signaling pathway on nasopharyngeal carcinoma (NPC cells in vitro and in vivo, and investigated the ability of Met tyrosine kinase inhibitor (TKI to block HGF-induced biological signaling.Experimental design: Met TKI inhibitor PF-2341066 alone, or in combination with cisplatin, was investigated for its ability to block HGF-induced signaling and biological effects in vitro and in vivo. HGF/Met expression and activation of signaling in NPC cells were detected by using Western blot and immunohistochemistry. Biological evaluation, including wound healing, cell proliferation, and invasion of NPC cells, was also examined, and the correlation between HGF/Met expression of primary and metastatic tumor in NPC patients and clinical prognosis were also analyzed.Results: Met TKI inhibitor, PF-2341066, inhibited growth of NPC cells in vivo with half maximal inhibitory concentration of 0.79±0.21 µmol/L, and suppressed invasion and migration of NPC cells; also, the inhibition of PF-2341066 was synergized with cisplatin treatment. Compared with the control group, Met TKI inhibited metastasis of transplanted NPC in nude mice (the number of live metastases [mean ± SD]: 5.8±2.2 versus 11.8±2.2, P=0.03; the number of lung metastases: 2.3±1.5 versus

  9. The patellofemoral pain and osteoarthritis subscale of the KOOS (KOOS-PF)

    DEFF Research Database (Denmark)

    Crossley, Kay M; Macri, Erin M; Cowan, Sallie M

    2018-01-01

    with patellofemoral pain and/or osteoarthritis and 14 health and medical clinicians. Item reduction was performed using data from patellofemoral cohorts (n=138). We used the COnsesus-based Standards for the selection of health Measurements INstruments guidelines to evaluate reliability, validity, responsiveness......BACKGROUND: Patellofemoral pain and osteoarthritis are prevalent and associated with substantial pain and functional impairments. Patient-reported outcome measures (PROMs) are recommended for research and clinical use, but no PROMs are specific for patellofemoral osteoarthritis, and existing PROMs...... for patellofemoral pain have methodological limitations. This study aimed to develop a new subscale of the Knee injury and Osteoarthritis Outcome Score for patellofemoral pain and osteoarthritis (KOOS-PF), and evaluate its measurement properties. METHODS: Items were generated using input from 50 patients...

  10. Statistical fluctuations of electromagnetic transition intensities in pf-shell nuclei

    International Nuclear Information System (INIS)

    Hamoudi, A.; Nazmitdinov, R.G.; Shakhaliev, E.; Alhassid, Y.

    2000-01-01

    We study the fluctuation properties of ΔT = 0 electromagnetic transition intensities in A ∼ 60 nuclei within the framework of the interacting shell model, using a realistic effective interaction for pf-shell nuclei with a 56 Ni core. It is found that the B(E2) and the ΔJ ≠ 0 distributions are well described by the Gaussian orthogonal ensemble of random matrices (Porter-Thomas distribution) independently of the isobaric quantum number T Z . However, the statistics of the B(M1) transitions with Δ = 0 are sensitive to T Z : T Z = 1 nuclei exhibit a Porter-Thomas distribution, while a significant deviation from the GOE statistics is observed for self-conjugate nuclei (T Z = 0). Similar results are found for A = 22 sd-shell nuclei

  11. TRAC-PF1: an advanced best-estimate computer program for pressurized water reactor analysis

    International Nuclear Information System (INIS)

    Liles, D.R.; Mahaffy, J.H.

    1984-02-01

    The Transient Reactor Analysis Code (TRAC) is being developed at the Los Alamos National Laboratory to provide advanced best-estimate predictions of postulated accidents in light water reactors. The TRAC-PF1 program provides this capability for pressurized water reactors and for many thermal-hydraulic experimental facilities. The code features either a one-dimensional or a three-dimensional treatment of the pressure vessel and its associated internals; a two-phase, two-fluid nonequilibrium hydrodynamics model with a noncondensable gas field; flow-regime-dependent constitutive equation treatment; optional reflood tracking capability for both bottom flood and falling-film quench fronts; and consistent treatment of entire accident sequences including the generation of consistent initial conditions. This report describes the thermal-hydraulic models and the numerical solution methods used in the code. Detailed programming and user information also are provided

  12. An overview of the TA-55, Building PF-4 ventilation system

    International Nuclear Information System (INIS)

    1994-01-01

    An overview of the TA-55, Building PF-4 ventilation system is provided in the following sections. Included are descriptions of the zone configurations, equipment-performance criteria, ventilation support systems, and the ventilation-system evaluation criteria. Section 4.2.1.1 provides a brief discussion of the ventilation system function. Section 4.2.1.2 provides details on the overall system configuration. Details of system interfaces and support systems are provided in Section 4.2.1.3. Section 4.2.1.4 describes instrumentation and control needed to operate the ventilation system. Finally, Sections 4.2.1.5 and 4.2.1.6 describe system surveillance/maintenance and Technical Safety Requirements (TSR) Limitations, respectively. Note that the numerical parameters included in this description are considered nominal; set points and other specifications actually fall within operational bands

  13. PF-AR NW14, a new time-resolved diffraction/scattering beamline

    International Nuclear Information System (INIS)

    Nozawa, Shunsuke; Adachi, Shin-ichi; Tazaki, Ryoko; Takahashi, Jun-ichi; Itatani, Jiro; Daimon, Masahiro; Mori, Takeharu; Sawa, Hiroshi; Kawata, Hiroshi; Koshihara, Shin-ya

    2005-01-01

    NW14 is a new insertion device beamline at the Photon Factory Advanced Ring (PF-AR), which is a unique ring with full-time single-bunched operation, aiming for timeresolved x-ray diffraction/scattering and XAFS experiments. The primary scientific goal of this beamline is to observe the ultrafast dynamics of condensed matter systems such as organic and inorganic crystals, biological systems and liquids triggered by optical pulses. With the large photon fluxes derived from the undulator, it should become possible to take a snapshoot an atomic-scale image of the electron density distribution. By combining a series of images it is possible to produce a movie of the photo-induced dynamics with 50-ps resolution. The construction of the beamline is being funded by the ERATO Koshihara Non-equilibrium Dynamics Project of the Japan Science and Technology Agency (JST), and the beamline will be operational from autumn 2005

  14. Power law field dependence of the 2D magnetoresistance in (TMTSF)2PF6

    International Nuclear Information System (INIS)

    Kriza, G.; Szeghy, G.; Kezsmarki, I.; Mihaly, G.

    1999-01-01

    The magnetoresistance of the quasi-one-dimensional organic conductor (TMTSF) 2 PF 6 is studied for currents flowing parallel to the best conducting a and second best conducting b directions in magnetic fields perpendicular to the a-b plane under a hydrostatic pressure of 0.8 GPa. As a function of the magnetic field, the magnetoresistance follows a power law ΔR/R = (B/B 0 ) 3/2 both in the a and b directions. The a-b plane conductivity anisotropy is field independent. The scaling field B 0 , characterizing the strength of the magnetoresistance, follows an exponential temperature dependence B 0 ∝exp(T/T 0 ) with a field-independent characteristic temperature T 0 = 10 K. (orig.)

  15. Galvanomagnetic properties in the spin-density-wave phase of (TMTSF)2PF6

    International Nuclear Information System (INIS)

    Korin-Hamzic, B.; Bechgaard, K.

    1999-01-01

    We have measured the magnetoresistance and the Hall effect in the spin-density-wave (SDW) state of (TMTSF) 2 PF 6 down to 2 K and in magnetic fields up to 9 T in order to gain an additional insight into the nature of the possible subphases in the SDW state. We have found that the temperature dependent magnetoresistance anisotropy changes below 4 K; this change being maximal for the current in the lowest conductivity direction. The Hall resistivity has showed different magnetic field dependencies for T>4 K and T<4 K. The resistivity and the Hall resistivity were also investigated as the function of the electric field. The backflow coefficient α does not change below 4 K. (orig.)

  16. Anisotropic p-f mixing mechanism explaining anomalous magnetic properties in Ce monopnictides

    International Nuclear Information System (INIS)

    Takahashi, H.; Kasuya, T.

    1985-01-01

    An anomalously small crystal-field splitting in the paramagnetic region in CeSb and CeBi compared with those in CeP and CeAs is explained by the mixing mechanism between the occupied 4f states and the valence band holes. In the paramagnetic regions, the above p-f mixing gives the effective crystal-field splitting, which is estimated to nearly cancel the normal splittings extrapolated from CeP and CeAs in good agreement with experiment. The formula for the second-order transition temperature, at which the population ratio of the 4f GAMMA 8 states begins to be unbalanced, is also derived. In CeBi the second-order transition may occur, while in CeSb the first-order transition should occur in agreement with experiments. (author)

  17. PF-AR NW14, a new time-resolved diffraction/scattering beamline

    Science.gov (United States)

    Nozawa, Shunsuke; Adachi, Shin-ichi; Tazaki, Ryoko; Takahashi, Jun-ichi; Itatani, Jiro; Daimon, Masahiro; Mori, Takeharu; Sawa, Hiroshi; Kawata, Hiroshi; Koshihara, Shin-ya

    2005-01-01

    NW14 is a new insertion device beamline at the Photon Factory Advanced Ring (PF-AR), which is a unique ring with full-time single-bunched operation, aiming for timeresolved x-ray diffraction/scattering and XAFS experiments. The primary scientific goal of this beamline is to observe the ultrafast dynamics of condensed matter systems such as organic and inorganic crystals, biological systems and liquids triggered by optical pulses. With the large photon fluxes derived from the undulator, it should become possible to take a snapshoot an atomic-scale image of the electron density distribution. By combining a series of images it is possible to produce a movie of the photo-induced dynamics with 50-ps resolution. The construction of the beamline is being funded by the ERATO Koshihara Non-equilibrium Dynamics Project of the Japan Science and Technology Agency (JST), and the beamline will be operational from autumn 2005.

  18. Study of the Plasma Evolution in the PF-1000 Device by Means of Optical Diagnostics

    International Nuclear Information System (INIS)

    Kasperczuk, A.; Kumar, R.; Miklaszewski, R.; Paduch, M.; Pisarczyk, T.; Scholz, M.; Tomaszewski, K.

    2002-01-01

    Investigation of a plasma evolution was carried out in a PF-1000 device with the following parameters: diameter of the inner electrode -24.4 cm, diameter of the outer one -36.8 cm, charging voltage in the range of 30-40 kV and deuterium pressure in the range of 1-5 1 To study the evolution of the plasma, an optical frame camera and YAGlaser shadowgraphy, both with exposure times of about 1 ns, were employed. Among the cases analyzed of plasma focus discharges, two types of plasma sheath disturbance can be distinguished: type I - classical MHD m = 0 instability (a wave with four maxima in the main), type 11 - singular great scale disturbance. On the basis of the plasma images, the dynamics of the plasma sheath, characteristic periods of the plasma evolution and plasma dimensions were determined. In order to reconstruct the spatial distribution of the electron density a special method was prepared

  19. An overview of the TA-55, Building PF-4 ventilation system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-02-22

    An overview of the TA-55, Building PF-4 ventilation system is provided in the following sections. Included are descriptions of the zone configurations, equipment-performance criteria, ventilation support systems, and the ventilation-system evaluation criteria. Section 4.2.1.1 provides a brief discussion of the ventilation system function. Section 4.2.1.2 provides details on the overall system configuration. Details of system interfaces and support systems are provided in Section 4.2.1.3. Section 4.2.1.4 describes instrumentation and control needed to operate the ventilation system. Finally, Sections 4.2.1.5 and 4.2.1.6 describe system surveillance/maintenance and Technical Safety Requirements (TSR) Limitations, respectively. Note that the numerical parameters included in this description are considered nominal; set points and other specifications actually fall within operational bands.

  20. Statistical fluctuations of electromagnetic transition intensities and electromagnetic moments in pf-shell nuclei

    International Nuclear Information System (INIS)

    Hamoudi, A.; Shahaliev, E.; Nazmitdinov, R. G.; Alhassid, Y.

    2002-01-01

    We study the fluctuation properties of ΔT=0 electromagnetic transition intensities and electromagnetic moments in A∼60 nuclei within the framework of the interacting shell model, using a realistic effective interaction for pf-shell nuclei with a 56 Ni core. The distributions of the transition intensities and of the electromagnetic moments are well described by the Gaussian orthogonal ensemble of random matrices. In particular, the transition intensity distributions follow a Porter-Thomas distribution. When diagonal matrix elements (i.e., moments) are included in the analysis of transition intensities, the distributions remain Porter-Thomas except for the isoscalar M1. This deviation is explained in terms of the structure of the isoscalar M1 operator

  1. [Study on method of tracking the active cells in image sequences based on EKF-PF].

    Science.gov (United States)

    Tang, Chunming; Liu, Ying

    2013-02-01

    In cell image sequences, due to the nonlinear and nonGaussian motion characteristics of active cells, the accurate prediction and tracking is still an unsolved problem. We applied extended Kalman particle filter (EKF-PF) here in our study, attempting to solve the problem. Firstly we confirmed the existence and positions of the active cells. Then we established a motion model and improved it via adding motion angle estimation. Next we predicted motion parameters, such as displacement, velocity, accelerated velocity and motion angle, in region centers of the cells being tracked. Finally we obtained the motion traces of active cells. There were fourteen active cells in three image sequences which have been tracked. The errors were less than 2.5 pixels when the prediction values were compared with actual values. It showed that the presented algorithm may basically reach the solution of accurate predition and tracking of the active cells.

  2. Crispy in the french breakfast

    Directory of Open Access Journals (Sweden)

    Alain Drouard

    2003-09-01

    Full Text Available Bien qu’il y ait eu du croquant et du croustillant dans l’alimentation des Français avant l’époque contemporaine (pain, gâteaux, fruits frais ou secs sa place a augmenté récemment à la suite des changements intervenus dans le petit déjeuner. Le but de cet article est d’analyser historiquement la pénétration et la diffusion du croquant et du croustillant dans le petit déjeuner français. Celle ci s’est faite d’abord dans les villes sous l’influence de modèles étrangers et principalement Anglo-Saxons qui font une place importante au croustillant. Les partisans des nouveaux petits déjeuners à base de lait, de céréales et de fruits ne cherchaient pas seulement à promouvoir le végétarisme mais aussi à lutter contre la « dégénérescence » qui menaçait à leurs yeux la société moderne. Après avoir rappelé la naissance du petit déjeuner français, on étudiera le rôle des modèles étrangers dans l’évolution de la consommation d’aliments croustillants.Though crispy items were present in French food before the contemporary period (what with bread, cakes, fresh or dried fruits, they have recently played a more important part as breakfast underwent a series of changes. The aim of this article is to make an historical analysis of the emergence and spread of crispy food in the French breakfast. The influence of foreign and more especially Anglo-Saxon models contributed to increasing its importance. Those who advocated these new breakfasts at the beginning of the XXth century were convinced to fight also against “degeneracy” which they thought was a threat to modern society. I shall first briefly explain how the French breakfast was born, then I shall focus on the influence and impact of foreign models.

  3. Multiscale Simulations of Lamellar PS–PEO Block Copolymers Doped with LiPF6 Ions

    KAUST Repository

    Sethuraman, Vaidyanathan

    2017-06-02

    We report the results of atomistic simulations of the structural equilibrium properties of PS–PEO block copolymer (BCP) melt in the ordered lamellar phase doped with LiPF6 salt. A hybrid simulation strategy, consisting of steps of coarse-graining and inverse coarse-graining, was employed to equilibrate the melt at an atomistic resolution in the ordered phase. We characterize the structural distributions between different atoms/ions and compare the features arising in BCPs against the corresponding behavior in PEO homopolymers for different salt concentrations. In addition, the local structural distributions are characterized in the lamellar phase as a function of distance from the interface. The cation–anion radial distribution functions (RDF) display stronger coordination in the block copolymer melts at high salt concentrations, whereas the trends are reversed for low salt concentrations. Radial distribution functions isolated in the PEO and PS domains demonstrate that the stronger coordination seen in BCPs arises from the influence of both the higher fraction of ions segregated in the PS phase and the influence of interactions in the PS domain. Such a behavior also manifests in the cation–anion clusters, which show a larger fraction of free ions in the BCP. While the average number of free anions (cations) decreases with increasing salt concentration, higher order aggregates of LiPF6 increase with increasing salt concentration. Further, the cation–anion RDFs display spatial heterogeneity, with a stronger cation–anion binding in the interfacial region compared to bulk of the PEO domain.

  4. Measurements of nitrous oxide emissions from P.F. fired power stations

    Science.gov (United States)

    Sloan, S. A.; Laird, C. K.

    Nitrous oxide (N 2O) was measured in the flue gas from four wall-fired and three corner-fired 500 MW boilers, fitted with either conventional or low-NO x burners, at four C.E.G.B. power stations. Measurements were made both by on-line non-dispersive infra red (NDIR) monitors and by extractive sampling for later laboratory analysis by electron capture gas chromatography (ECD GC). It was found that the on-line and laboratory methods were in good agreement for samples analyzed within 1-3 h of sampling, but that the nitrous oxide concentration in the stored samples had a tendency to increase with time, which was dependent on the concentration of water in the sample. Experiments with synthetic mixtures showed that the increase in nitrous oxide concentration was consistent with the overall reaction2NO+SO 2→N 2O+SO 3 in which nitric oxide is reduced by sulphur dioxide. The highest average N 2O concentration measured by the on-line analyzer was 16 vpm, and for most of the boilers monitored the concentration was less than 10 vpm. There was no statistically significant difference between the measured N 2O emissions from normal boilers and those fitted with low-NO x burners. It is suggested that these values are close to the true levels of N 2O emissions from p.f. fired boilers and that recent reports of high levels (up to 200 vpm) are likely to be an artefact resulting from the observed generation of N 2O in stored samples. A consequence of these measurements of N 2O is that current estimates of the contribution of emissions from p.f. fired boilers to the global N 2O budget are likely to be too high.

  5. Spectrophotometric assessment of the effectiveness of Opalescence PF 10%: a 14-month clinical study.

    Science.gov (United States)

    Grobler, S R; Hayward, R; Wiese, S; Moola, M H; van W Kotze, T J

    2010-02-01

    To evaluate the effectiveness of Opalescence PF 10% just after treatment, at 6-month follow-up and at a 14-month follow-up period. Opalescence PF 10% was applied nightly for 14 days. The color of teeth 11 and 21 of 17 subjects were measured with a spectrophotometer (L*; a*; b*) before treatment, just after treatment (14 days), after 6 months and after 14 months. Subjects were instructed to take note of any tooth sensitivity. For all three components (L*, a* and b*) statistical significant differences (p<0.05) in the values between base-line, after treatment (14 days later), after 6 months and after 14 months were found (Wilcoxon Signed Rank Sum Test). The decrease in L* was about 20% after 6 months and about 50% after 14 months. The a* value decreased approximately 14% after 6 months but was worse after 14 months than at the beginning. The b* value decreased the least with about 9% after 6 months and about 8% after 14 months. The decrease in DeltaE(ab)(*) was approximately 20% after 14 months. Less than 20% of the subjects experienced mild tooth sensitivity just after treatment. Significantly whiter teeth were found after treatment as well as after a 6-month follow-up period. The whiteness/brightness (L*) decreased with approximately 50% after 14 months and the a* value with approximately 50% after 7 months, while the yellowness (b* value) remained even after 14 months. The product is an effective tooth whitener resulting in only low tooth sensitivity. Re-bleaching could be done at about 14 months. Copyright 2009 Elsevier Ltd. All rights reserved.

  6. Development of Gender Typicality and Felt Pressure in European French and North African French Adolescents.

    Science.gov (United States)

    Hoffman, Adam J; Dumas, Florence; Loose, Florence; Smeding, Annique; Kurtz-Costes, Beth; Régner, Isabelle

    2017-11-14

    Trajectories of gender identity were examined from Grade 6 (M age  = 11.9 years) to Grade 9 in European French (n = 570) and North African French (n = 534) adolescents, and gender and ethnic group differences were assessed in these trajectories. In Grade 6, boys of both ethnic groups reported higher levels of gender typicality and felt pressure for gender conformity than girls. European French girls and boys and North African French girls reported decreasing gender typicality from Grade 6 to Grade 9, whereas North African French boys did not change. Felt pressure decreased among girls, did not change in European French boys, and increased in North African French boys. Ethnic and gender differences in gender identity development are discussed. © 2017 The Authors. Child Development © 2017 Society for Research in Child Development, Inc.

  7. The Exported Chaperone PfHsp70x Is Dispensable for the Plasmodium falciparum Intraerythrocytic Life Cycle.

    Science.gov (United States)

    Cobb, David W; Florentin, Anat; Fierro, Manuel A; Krakowiak, Michelle; Moore, Julie M; Muralidharan, Vasant

    2017-01-01

    Export of parasite proteins into the host erythrocyte is essential for survival of Plasmodium falciparum during its asexual life cycle. While several studies described key factors within the parasite that are involved in protein export, the mechanisms employed to traffic exported proteins within the host cell are currently unknown. Members of the Hsp70 family of chaperones, together with their Hsp40 cochaperones, facilitate protein trafficking in other organisms, and are thus likely used by P. falciparum in the trafficking of its exported proteins. A large group of Hsp40 proteins is encoded by the parasite and exported to the host cell, but only one Hsp70, P. falciparum Hsp70x (PfHsp70x), is exported with them. PfHsp70x is absent in most Plasmodium species and is found only in P. falciparum and closely related species that infect apes. Herein, we have utilized clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 genome editing in P. falciparum to investigate the essentiality of PfHsp70x. We show that parasitic growth was unaffected by knockdown of PfHsp70x using both the dihydrofolate reductase (DHFR)-based destabilization domain and the glmS ribozyme system. Similarly, a complete gene knockout of PfHsp70x did not affect the ability of P. falciparum to proceed through its intraerythrocytic life cycle. The effect of PfHsp70x knockdown/knockout on the export of proteins to the host red blood cell (RBC), including the critical virulence factor P. falciparum erythrocyte membrane protein 1 (PfEMP1), was tested, and we found that this process was unaffected. These data show that although PfHsp70x is the sole exported Hsp70, it is not essential for the asexual development of P. falciparum . IMPORTANCE Half of the world's population lives at risk for malaria. The intraerythrocytic life cycle of Plasmodium spp. is responsible for clinical manifestations of malaria; therefore, knowledge of the parasite's ability to survive within the erythrocyte is

  8. Diagnosing severe falciparum malaria in parasitaemic African children: a prospective evaluation of plasma PfHRP2 measurement.

    Directory of Open Access Journals (Sweden)

    Ilse C E Hendriksen

    Full Text Available In African children, distinguishing severe falciparum malaria from other severe febrile illnesses with coincidental Plasmodium falciparum parasitaemia is a major challenge. P. falciparum histidine-rich protein 2 (PfHRP2 is released by mature sequestered parasites and can be used to estimate the total parasite burden. We investigated the prognostic significance of plasma PfHRP2 and used it to estimate the malaria-attributable fraction in African children diagnosed with severe malaria.Admission plasma PfHRP2 was measured prospectively in African children (from Mozambique, The Gambia, Kenya, Tanzania, Uganda, Rwanda, and the Democratic Republic of the Congo aged 1 month to 15 years with severe febrile illness and a positive P. falciparum lactate dehydrogenase (pLDH-based rapid test in a clinical trial comparing parenteral artesunate versus quinine (the AQUAMAT trial, ISRCTN 50258054. In 3,826 severely ill children, Plasmadium falciparum PfHRP2 was higher in patients with coma (p = 0.0209, acidosis (p<0.0001, and severe anaemia (p<0.0001. Admission geometric mean (95%CI plasma PfHRP2 was 1,611 (1,350-1,922 ng/mL in fatal cases (n = 381 versus 1,046 (991-1,104 ng/mL in survivors (n = 3,445, p<0.0001, without differences in parasitaemia as assessed by microscopy. There was a U-shaped association between log(10 plasma PfHRP2 and risk of death. Mortality increased 20% per log(10 increase in PfHRP2 above 174 ng/mL (adjusted odds ratio [AOR] 1.21, 95%CI 1.05-1.39, p = 0.009. A mechanistic model assuming a PfHRP2-independent risk of death in non-malaria illness closely fitted the observed data and showed malaria-attributable mortality less than 50% with plasma PfHRP2≤174 ng/mL. The odds ratio (OR for death in artesunate versus quinine-treated patients was 0.61 (95%CI 0.44-0.83, p = 0.0018 in the highest PfHRP2 tertile, whereas there was no difference in the lowest tertile (OR 1.05; 95%CI 0.69-1.61; p = 0.82. A limitation of the study is that some

  9. Stars War in French Gastronomy

    DEFF Research Database (Denmark)

    Gergaud, Olivier; Smeets, Valérie; Warzynski, Frederic

    In this paper, we analyze the careers from a sample of more than 1,000 top French chefs over more than twenty years and link it to the success or reputation of the restaurants where they have worked. This allows us to test what are the determinants of success but also to investigate the dynamics...... of performance and reputation, stressing the importance of the quality of apprenticeships, mentoring and entrepreneurship spirit. We find that the prestige of the restaurant where individuals work is on average declining along the career, and that the quality of apprenticeship is strongly related to the future...... success as chef. We also find that prices of restaurants with higher reputation are more sensitive to bad signals....

  10. Disputing Rossellini: Three French perspectives

    Directory of Open Access Journals (Sweden)

    James Harvey-Davitt

    2014-12-01

    Full Text Available In his burgeoning body of film theoretical work the French philosopher Jacques Rancière repeatedly turns to some canonical films by Neorealist pioneer Roberto Rossellini. Not simply retreading tired motifs of Neorealism, Rancière’s comments offer some profound new insights, revolutionising prior perspectives on Rossellini. In this article I shall put Rancière’s perspective into dialogue with two of the most significant of these perspectives: André Bazin’s and Gilles Deleuze’s. In doing so I shall claim that Rancière’s approach departs radically from the canonised, standardised Neorealist conception of Rossellini. Instead, I wish to claim that he describes a modernist artist primarily concerned with aesthetic clashes. In doing so I shall contemplate how the meaning of these films has evolved since the era of their contemporary reception, demonstrating the congruence and disparity between these three disparate approaches.

  11. Impact of French advertising campaign

    International Nuclear Information System (INIS)

    Chaussade, Jean-Pierre; Ansel, Philippe

    1993-01-01

    'Today, some 75 % of France's electricity is generated by nuclear plants'. This was the theme of the advertising campaign launched for the second time in May 1992 by Electricite de France in national daily newspapers and magazines, in regional publications, on cinema and on TV. Compared to 1991 the second campaign was a new step in communication: first, was the wish to inform better the public. A Minitel program '3614 EDF' was created and connected by general public including a lot of information about nuclear energy and the way to visit a nuclear plant; secondly, was the use of TV media to target a larger population. The TV spot, 'the nuclear drill', uses humor to get more impact on the public. The campaign received an encouraging reception from the press, which admired its boldness and originality. As far as the general public is concerned, the campaign achieved its goals, as illustrated by the results of post-campaign surveys carried out to measure its effect. The segment of population targeted by campaign was mainly the so called 'pragmatics'. 'Pragmatics', who account for 25 % of the French population, are young, have a good education and are well informed. This category was selected as it shows a subtle attitude towards nuclear power, with more doubts than certainties. Moreover, this segment of the population has proven to be open to information issued by EDF and also plays a key role in influencing social trends. 63% of the segment targeted by the campaign (pragmatics) and 56% of the whole french population saw the ads

  12. The debate over the creation of a Museum of Modern Art in Paris between the wars and the shaping of an evolutionary narrative for French art

    Directory of Open Access Journals (Sweden)

    Chara Kolokytha

    2016-12-01

    Full Text Available The paper comments on the state policies towards modern art throughout the interwar period identifying the private initiatives that sought to precipitate the creation of a museum of contemporary art in Paris. It seeks to discuss the debate over the necessity for the creation of a Museum of Modern Art in Paris that was initiated in the Parisian press shortly after the controversial “Exposition Internationale des Arts Décoratifs et Industriels Modernes”, in 1925, and was perpetuated with the re-organisation of the collections of the Louvre, the Luxembourg museum, and the Jeu de Paume in the late 1920s. The offi cial announcement, in 1934, of the creation of a museum of modern art in Paris, in 1937, initiated a new debate that concerned its collections. A series of exhibitions organised on the occasion of  the “Exposition Internationale des Arts et Techniques”, in 1937, served as a model for the shaping of an evolutionary narrative for French art in which modern art that emerged from 1905 to 1925 appeared as the culmination of the French art tradition. However, the infl uence of foreign artists over French modern art was largely contested, while the discussion initiated by the champions of an international school added a nonconformist nuance to a nationally-oriented dialogue. L’articolo affronta le politiche statali nei confronti dell’arte moderna nel periodo compreso tra le due guerre, individuando anche le iniziative private che hanno cercato di spingere verso la creazione di un museo di arte contemporanea a Parigi. Esso cerca di ricostruire il dibattito avviato sulla stampa parigina poco dopo la controversa “Exposition Internationale des Arts Décoratifs et Industriels Modernes” del 1925, proseguito con la riorganizzazione delle collezioni del Louvre, del museo del Luxembourg e del Jeu de Paume alla fine degli anni Venti. L’annuncio uffi ciale della creazione di un museo d’arte moderna a Parigi, nel 1934, avvia un nuovo

  13. Rhizoxin analogs, orfamide A and chitinase production contribute to the toxicity of Pseudomonas protegens strain Pf-5 to Drosophila melanogaster

    Science.gov (United States)

    Pseudomonas protegens strain Pf-5 is a soil bacterium that was first described for its activity in biological control of plant diseases and has since been shown to be lethal to certain insects. Among these is the fruit fly Drosophila melanogaster, a well-established model organism for studies evalu...

  14. Multidimensional protein fractionation using ProteomeLab PF 2D™ for profiling amyotrophic lateral sclerosis immunity: A preliminary report

    Directory of Open Access Journals (Sweden)

    Mosley R Lee

    2008-09-01

    Full Text Available Abstract Background The ProteomeLab™ PF 2D platform is a relatively new approach to global protein profiling. Herein, it was used for investigation of plasma proteome changes in amyotrophic lateral sclerosis (ALS patients before and during immunization with glatiramer acetate (GA in a clinical trial. Results The experimental design included immunoaffinity depletion of 12 most abundant proteins from plasma samples with the ProteomeLab™ IgY-12 LC10 column kit as first dimension separation, also referred to as immuno-partitioning. Second and third dimension separations of the enriched proteome were performed on the PF 2D platform utilizing 2D isoelectric focusing and RP-HPLC with the resulting fractions collected for analysis. 1D gel electrophoresis was added as a fourth dimension when sufficient protein was available. Protein identification from collected fractions was performed using nano-LC-MS/MS approach. Analysis of differences in the resulting two-dimensional maps of fractions obtained from the PF 2D and the ability to identify proteins from these fractions allowed sensitivity threshold measurements. Masked proteins in the PF 2D fractions are discussed. Conclusion We offer some insight into the strengths and limitations of this emerging proteomic platform.

  15. Input data preparation and simulation of the second standard problem of IAEA using the Trac/PF1 code

    International Nuclear Information System (INIS)

    Madeira, A.A.; Pontedeiro, A.C.; Silva Galetti, M.R. da; Borges, R.C.

    1989-10-01

    The second Standard Problem sponsored by IAEA consists in the simulation of a small LOCA located in the downcomer of a PMK-NVH integral test facility, which models WWER/440 type reactor. This report presents input data preparation and comparison between TRAC-PF1 results and experimental measurements. (author) [pt

  16. Antigenic variation and the genetics and epigenetics of the PfEMP1 erythrocyte surface antigens in Plasmodium falciparum malaria

    DEFF Research Database (Denmark)

    Arnot, David E; Jensen, Anja T R

    2011-01-01

    . Sterile immunity is not achieved and chronic parasitization of apparently healthy adults is the norm. In this article, we analyse the best understood malaria "antigenic variation" system, that based on Plasmodium falciparum's PfEMP1-type cytoadhesion antigens, and critically review recent literature...

  17. Phloroglucinol mediates crosstalk between the pyoluteorin and 2,4-diacetylphloroglucinol biosynthetic pathways in Pseudomonas fluorescens Pf-5

    Science.gov (United States)

    The antibiotics pyoluteorin and 2,4-diacetylphloroglucinol (DAPG) are involved in the biological control of certain soil-borne diseases by some strains of Pseudomonas fluorescens, including P. fluorescens Pf-5. These secondary metabolites also act as signaling molecules with each compound reported ...

  18. PfClpC Is an Essential Clp Chaperone Required for Plastid Integrity and Clp Protease Stability in Plasmodium falciparum

    Directory of Open Access Journals (Sweden)

    Anat Florentin

    2017-11-01

    Full Text Available Summary: The deadly malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid, known as the apicoplast, that functions to produce essential metabolites, and drugs that target the apicoplast are clinically effective. Several prokaryotic caseinolytic protease (Clp genes have been identified in the Plasmodium genome. Using phylogenetic analysis, we focused on the Clp members that may form a regulated proteolytic complex in the apicoplast. We genetically targeted members of this complex and generated conditional mutants of the apicoplast-localized PfClpC chaperone and PfClpP protease. Conditional inhibition of the PfClpC chaperone resulted in growth arrest and apicoplast loss and was rescued by addition of the essential apicoplast-derived metabolite IPP. Using a double-conditional mutant parasite line, we discovered that the chaperone activity is required to stabilize the mature protease, revealing functional interactions. These data demonstrate the essential function of PfClpC in maintaining apicoplast integrity and its role in regulating the proteolytic activity of the Clp complex. : Plasmodium falciparum contains a unique organelle, the apicoplast. Using genetic and phenotypic assays, Florentin et al. characterize the apicoplast Clp chaperone and protease. They find that the chaperone is essential for protease stability and that together they function to maintain organelle integrity and segregation into daughter cells. Keywords: malaria, Plasmodium, apicoplast, IPP, Clp, chaperone, caseinolytic protease

  19. Cross-reactive anti-PfCLAG9 antibodies in the sera of asymptomatic parasite carriers of Plasmodium vivax

    Science.gov (United States)

    Costa, Joana D'Arc Neves; Zanchi, Fernando Berton; Rodrigues, Francisco Lurdevanhe da Silva; Honda, Eduardo Rezende; Katsuragawa, Tony Hiroschi; Pereira, Dhélio Batista; Taborda, Roger Lafontaine Mesquita; Tada, Mauro Shugiro; Ferreira, Ricardo de Godoi Mattos; Pereira-da-Silva, Luiz Hildebrando

    2013-01-01

    The PfCLAG9 has been extensively studied because their immunogenicity. Thereby, the gene product is important for therapeutics interventions and a potential vaccine candidate. Antibodies against synthetic peptides corresponding to selected sequences of the Plasmodium falciparum antigen PfCLAG9 were found in sera of falciparum malaria patients from Rondônia, in the Brazilian Amazon. Much higher antibody titres were found in semi-immune and immune asymptomatic parasite carriers than in subjects suffering clinical infections, corroborating original findings in Papua Guinea. However, sera of Plasmodium vivax patients from the same Amazon area, in particular from asymptomatic vivax parasite carriers, reacted strongly with the same peptides. Bioinformatic analyses revealed regions of similarity between P. falciparum Pfclag9 and the P. vivax ortholog Pvclag7. Indirect fluorescent microscopy analysis showed that antibodies against PfCLAG9 peptides elicited in BALB/c mice react with human red blood cells (RBCs) infected with both P. falciparum and P. vivax parasites. The patterns of reactivity on the surface of the parasitised RBCs are very similar. The present observations support previous findings that PfCLAG9 may be a target of protective immune responses and raises the possibility that the cross reactive antibodies to PvCLAG7 in mixed infections play a role in regulate the fate of Plasmodium mixed infections. PMID:23440122

  20. Disruption of transporters affiliated with enantio-pyochelin biosynthesis gene cluster of Pseudomonas protegens Pf-5 has pleiotropic effects

    Science.gov (United States)

    Pseudomonas protegens Pf-5 (formerly Pseudomonas fluorescens) is a biocontrol bacterium that produces the siderophore enantio-pyochelin under conditions of iron starvation in a process that is often accompanied by the secretion of its biosynthesis intermediates, salicylic acid and dihydroaeruginoic ...

  1. Diagnostic systems for the nuclear fusion and plasma research in the PF-24 plasma focus laboratory at the IFJ PAN

    Directory of Open Access Journals (Sweden)

    Marciniak Łukasz

    2016-12-01

    Full Text Available This paper presents a set of diagnostics dedicated to PF-24 - new medium size - plasma focus (PF device built and operated at the Institute of Nuclear Physics Polish Academy of Sciences (IFJ PAN. The PF-24 can operate at energy level up to 93 kJ and charging voltage up to 40 kV. Each condenser is connected with a specially designed spark gap with a very small jitter, which ensures a high effi ciency and a low current rise time. The working parameters of PF-24 generator make it a suitable tool for testing new detection systems to be used in fusion research. Four types of such detection systems are presented in this article: three diagnostic systems used to measure electric quantities (Rogowski coil, magnetic probe, capacitance probe, neutron counter based on beryllium activation, fast neutron pinhole camera based on small-area BCF-12 plastic scintillation detectors and high-speed four-frame soft X-ray camera with microchannel plate.

  2. Chlamydomonas DYX1C1/PF23 is essential for axonemal assembly and proper morphology of inner dynein arms.

    Directory of Open Access Journals (Sweden)

    Ryosuke Yamamoto

    2017-09-01

    Full Text Available Cytoplasmic assembly of ciliary dyneins, a process known as preassembly, requires numerous non-dynein proteins, but the identities and functions of these proteins are not fully elucidated. Here, we show that the classical Chlamydomonas motility mutant pf23 is defective in the Chlamydomonas homolog of DYX1C1. The pf23 mutant has a 494 bp deletion in the DYX1C1 gene and expresses a shorter DYX1C1 protein in the cytoplasm. Structural analyses, using cryo-ET, reveal that pf23 axonemes lack most of the inner dynein arms. Spectral counting confirms that DYX1C1 is essential for the assembly of the majority of ciliary inner dynein arms (IDA as well as a fraction of the outer dynein arms (ODA. A C-terminal truncation of DYX1C1 shows a reduction in a subset of these ciliary IDAs. Sucrose gradients of cytoplasmic extracts show that preassembled ciliary dyneins are reduced compared to wild-type, which suggests an important role in dynein complex stability. The role of PF23/DYX1C1 remains unknown, but we suggest that DYX1C1 could provide a scaffold for macromolecular assembly.

  3. Redefining the PF06864 Pfam family based on Burkholderia pseudomallei PilO2(Bp S-SAD crystal structure.

    Directory of Open Access Journals (Sweden)

    Patricia Lassaux

    Full Text Available Type IV pili are surface-exposed filaments and bacterial virulence factors, represented by the Tfpa and Tfpb types, which assemble via specific machineries. The Tfpb group is further divided into seven variants, linked to heterogeneity in the assembly machineries. Here we focus on PilO2(Bp, a protein component of the Tfpb R64 thin pilus variant assembly machinery from the pathogen Burkholderia pseudomallei. PilO2(Bp belongs to the PF06864 Pfam family, for which an improved definition is presented based on newly derived Hidden Markov Model (HMM profiles. The 3D structure of the N-terminal domain of PilO2(Bp (N-PilO2(Bp, here reported, is the first structural representative of the PF06864 family. N-PilO2(Bp presents an actin-like ATPase fold that is shown to be present in BfpC, a different variant assembly protein; the new HMM profiles classify BfpC as a PF06864 member. Our results provide structural insight into the PF06864 family and on the Type IV pili assembly machinery.

  4. Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models.

    Science.gov (United States)

    Esquejo, Ryan M; Salatto, Christopher T; Delmore, Jake; Albuquerque, Bina; Reyes, Allan; Shi, Yuji; Moccia, Rob; Cokorinos, Emily; Peloquin, Matthew; Monetti, Mara; Barricklow, Jason; Bollinger, Eliza; Smith, Brennan K; Day, Emily A; Nguyen, Chuong; Geoghegan, Kieran F; Kreeger, John M; Opsahl, Alan; Ward, Jessica; Kalgutkar, Amit S; Tess, David; Butler, Lynne; Shirai, Norimitsu; Osborne, Timothy F; Steinberg, Gregory R; Birnbaum, Morris J; Cameron, Kimberly O; Miller, Russell A

    2018-04-08

    Dysregulation of hepatic lipid and cholesterol metabolism is a significant contributor to cardiometabolic health, resulting in excessive liver lipid accumulation and ultimately non-alcoholic steatohepatitis (NASH). Therapeutic activators of the AMP-Activated Protein Kinase (AMPK) have been proposed as a treatment for metabolic diseases; we show that the AMPK β1-biased activator PF-06409577 is capable of lowering hepatic and systemic lipid and cholesterol levels in both rodent and monkey preclinical models. PF-06409577 is able to inhibit de novo lipid and cholesterol synthesis pathways, and causes a reduction in hepatic lipids and mRNA expression of markers of hepatic fibrosis. These effects require AMPK activity in the hepatocytes. Treatment of hyperlipidemic rats or cynomolgus monkeys with PF-06409577 for 6weeks resulted in a reduction in circulating cholesterol. Together these data suggest that activation of AMPK β1 complexes with PF-06409577 is capable of impacting multiple facets of liver disease and represents a promising strategy for the treatment of NAFLD and NASH in humans. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

  5. The preparation and properties of a novel electrolyte of electrochemical double layer capacitors based on LiPF6 and acetamide

    International Nuclear Information System (INIS)

    Li Qi; Zuo Xiaoxi; Liu Jiansheng; Xiao Xin; Shu Dong; Nan Junmin

    2011-01-01

    A novel electrolyte applied in electrochemical double-layer capacitors (EDLCs) has been prepared based on lithium hexafluorophosphate (LiPF 6 ) and acetamide and subsequently characterized by differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), electrochemical techniques and so on. The mixtures of LiPF 6 and acetamide at the molar ratios of 1:4 to 1:6 exist as liquids below 25 °C, which is attributed to the melting point depression of mixture and the coordination of the polar groups (C=O and NH groups) of acetamide with Li + and PF 6 − ions. The strong interaction between LiPF 6 and acetamide results in the rupture of the electrovalent bond of LiPF 6 and the breakage of hydrogen bonds among the acetamide molecules, leading to the formation of a liquid electrolyte. The LiPF 6 /acetamide electrolyte with a molar ratio of 1:5.5 exhibits a 5.2 V electrochemical window and suitable ionic conductivity at room temperature. In particular, the coin-type cells with carbon electrodes and LiPF 6 /acetamide electrolyte possess high thermal stability and electrochemical properties, showing that the as-prepared LiPF 6 /acetamide electrolyte is a promising candidate for EDLCs.

  6. An inter-species signaling system mediated by fusaric acid has parallel effects on antifungal metabolite production by Pseudomonas protegens Pf-5 and antibiosis of Fusarium spp.

    Science.gov (United States)

    Pseudomonas protegens strain Pf-5 is a rhizosphere bacterium that acts as a biocontrol agent of soilborne plant diseases, and produces at least seven different secondary metabolites with antifungal properties. We derived site-directed mutants of Pf-5 with single and multiple mutations in the biosynt...

  7. PfPI3K, a Phosphatidylinsoitol-3 kinase in Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking

    CSIR Research Space (South Africa)

    Vaid, A

    2010-03-01

    Full Text Available largely unexplored. Our present studies suggest that PfPI3K, a novel phosphatidylinositol-3-kinase (PI3K) in Plasmodium falciparum, is exported to the host erythrocyte by the parasite in an active form. PfPI3K is a versatile enzyme as it can generate...

  8. French Society Abroad: The Popularization of French Dance throughout Europe, 1600-1750

    Directory of Open Access Journals (Sweden)

    Adam Paul Rinehart

    2017-09-01

    Full Text Available This paper explores the dissemination of French dance, dance notation, and dance music throughout Europe, and it explains the reasons why French culture had such an influence on other European societies from 1600-1750. First, the paper seeks to prove that King Louis XIV played a significant role in the outpour of French dance and the arts. Next, the paper discusses prominent French writers of dance notation who influenced the spread of French dance literature and training throughout Europe. Finally, the paper delineates European composers and their involvement in the development and production of French dance music. Using academic, peer-reviewed journal articles, books, and other scholarly sources, this paper seeks to accurately present the information in an orderly fashion. The paper contains visual evidence of dance and music notation to assist the reader in understanding the subject matter. Additionally, theories of contemporary authors as well as authors from the time period are discussed to present concrete evidence. The two main types of dance discussed in the paper are ballroom and court dances, which were prominent within the French royal court. One major finding of the research is the fact that French court and ballroom dances were specifically designed to communicate the power and prestige of King Louis XIV; consequently, other European countries were influenced to strive for similar prestige. Another finding is that many forms of French dance notation were translated and published in other countries, which increased the use of French dance throughout Europe. Musically, European composers such as Handel and Mozart included elements of French dance music in their compositions, and thus played a significant role in prevalence of French dance music throughout Europe. Overall, this paper proves that French dance received wide recognition due to political influence, availability of dance notation, and the involvement of prominent composers.

  9. The improvement of the heat transfer coupling between the flow field and the conduction slab for TRAC-PF1

    International Nuclear Information System (INIS)

    Wang, Lang Chen.

    1990-01-01

    A semi-implicit coupling technique (treating only the fluid temperature in the energy source term implicitly) of fluid heat-transfer to conduction slabs is presently used in TRAC-PF1. In this study, a fully implicit coupling scheme between the flow field and conduction slab for the one-dimensional capability of TRAC-PF1 has been developed. The new methods treat the heat-transfer coefficient and wall temperature in the energy source term of both the convection and the conduction equation implicitly. In order to test the accuracy of the standard TRAC coupling method and the new methods used in TRAC-PF1, a series of simple tube experiments were modeled with TRAC-PF1 version 3.9B. Additional studies showed the current TRAC-PF1 convergence variables (pressure fraction change and temperature change) and the current convergence criteria are not appropriate for obtaining an accurate result. Use of these values would produce non-physical double values or would adversely affect results in the reflood calculation. Another study also had been done to determine the importance of each HTC variable on computational accuracy and speed by using the non-linear oterative method. It is found that the heat-transfer correlations have a strong dependency on the local void fraction rather than on fluid velocity, fluid temperature, and wall surface temperature in the film boiling heat-transfer regime. At the beginning of a cooldown transient, the old time void fraction is always higher than the new time void fraction in the same time step. The old time void fraction evaluates a lower heat-transfer coefficient for that cell and initiates cooldown later and more slowly. This then leads to a longer quench time and lowers the fluid temperature and the wall temperature plateau for the downstream control volumes

  10. Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1

    Science.gov (United States)

    Moll, Kirsten; Palmkvist, Mia; Ch'ng, Junhong; Kiwuwa, Mpungu Steven; Wahlgren, Mats

    2015-01-01

    The ABO blood group antigens are expressed on erythrocytes but also on endothelial cells, platelets and serum proteins. Notably, the ABO blood group of a malaria patient determines the development of the disease given that blood group O reduces the probability to succumb in severe malaria, compared to individuals of groups A, B or AB. P. falciparum rosetting and sequestration are mediated by PfEMP1, RIFIN and STEVOR, expressed at the surface of the parasitized red blood cell (pRBC). Antibodies to these antigens consequently modify the course of a malaria infection by preventing sequestration and promoting phagocytosis of pRBC. Here we have studied rosetting P. falciparum and present evidence of an immune evasion mechanism not previously recognized. We find the accessibility of antibodies to PfEMP1 at the surface of the pRBC to be reduced when P. falciparum forms rosettes in blood group A RBC, as compared to group O RBC. The pRBC surrounds itself with tightly bound normal RBC that makes PfEMP1 inaccessible to antibodies and clearance by the immune system. Accordingly, pRBC of in vitro cloned P. falciparum devoid of ABO blood group dependent rosetting were equally well detected by anti-PfEMP1 antibodies, independent of the blood group utilized for their propagation. The pathogenic mechanisms underlying the severe forms of malaria may in patients of blood group A depend on the ability of the parasite to mask PfEMP1 from antibody recognition, in so doing evading immune clearance. PMID:26714011

  11. Spatial and temporal activity of the foxtail millet (Setaria italica) seed-specific promoter pF128.

    Science.gov (United States)

    Pan, Yanlin; Ma, Xin; Liang, Hanwen; Zhao, Qian; Zhu, Dengyun; Yu, Jingjuan

    2015-01-01

    pF128 drives GUS specifically expressed in transgenic seeds of foxtail millet and Zea mays with higher activity than the constitutive CaMV35S promoter and the maize seed-specific 19Z promoter. Foxtail millet (Setaria italica), a member of the Poaceae family, is an important food and fodder crop in arid regions. Foxtail millet is an excellent C4 crop model owing to its small genome (~490 Mb), self-pollination and availability of a complete genome sequence. F128 was isolated from a cDNA library of foxtail millet immature seeds. Real-time PCR analysis revealed that F128 mRNA was specifically expressed in immature and mature seeds. The highest F128 mRNA level was observed 5 days after pollination and gradually decreased as the seed matured. Sequence analysis suggested that the protein encoded by F128 is likely a protease inhibitor/seed storage protein/lipid-transfer protein. The 1,053 bp 5' flanking sequence of F128 (pF128) was isolated and fused to the GUS reporter gene. The corresponding vector was then transformed into Arabidopsis thaliana, foxtail millet and Zea mays. GUS analysis revealed that pF128 drove GUS expression efficiently and specifically in the seeds of transgenic Arabidopsis, foxtail millet and Zea mays. GUS activity was also detected in Arabidopsis cotyledons. Activity of pF128 was higher than that observed for the constitutive CaMV35S promoter and the maize seed-specific 19 Zein (19Z) promoter. These results indicate that pF128 is a seed-specific promoter. Its application is expected to be of considerable value in plant genetic engineering.

  12. The yawning chasm of French nuclear power

    International Nuclear Information System (INIS)

    Anon.

    1988-01-01

    This is an account of a paper appeared in Energy Economist, February 1988 and contains a severe critique of the French nuclear power policy, in particular the Electricite de France, Cogema and Framatome. It is argued that the blueprint of the original nuclear power program has not been achieved in many topics. Points of critique to the EdF are: the electricity price, overcapacities and financial indeptedness. The French industries are not flourishing due to ample supply of cheap energy, nor do French nuclear manufacturers sell the fast breeder technology throughout the world. (qui)

  13. French electric power balance sheet 2010

    International Nuclear Information System (INIS)

    Lartigau, Thierry; Riere, Alexia

    2011-01-01

    The mission of RTE, the French electricity Transportation grid, a public service assignment, is to balance the electricity supply and demand in real time. This report presents RTE's technical results for the year 2010: increase of RTE's investments and safety expenses for adapting the grid to the new electricity industry stakes and to meteorological hazards, decrease of power cuts frequency, rise of the French power consumption, strong increase of winter consumption peaks, increase of the French power generation, increase of the positive trade balance. New RTE's infrastructures, electricity quality data, and the evolution of market mechanisms are presented in appendixes

  14. Colloquial French the complete course for beginners

    CERN Document Server

    Demouy, Valérie

    2014-01-01

     COLLOQUIAL FRENCH is easy to use and completely up to date!Specially written by experienced teachers for self-study or class use, the course offers a step-by-step approach to written and spoken French. No prior knowledge of the language is required.What makes COLLOQUIAL FRENCH your best choice in personal language learning?Interactive - lots of exercises for regular practiceClear - concise grammar notesPractical - useful vocabulary and pronunciation guideComplete - including answer key and reference sectionWhether you''re a business traveller, or about to take up a daring challenge in adventu

  15. The cost of French military nuclear programs

    International Nuclear Information System (INIS)

    Barrillot, B.

    1999-02-01

    The author tries to find out the real cost of French nuclear weaponry. According to this study the total cost of the French military nuclear programs for 1960-1998 period is about 1499 milliard francs (MdF). This cost can be distributed as follows: i) fabrication of the bomb: 690 MdF; ii) display of the bomb: 727 MdF; iii) control of the bomb: 50 Mdf; iv) protection against nuclear attacks: 9 MdF; and v) dismantling of the bomb: 23 MdF. It goes without saying that these figures exceed by far those given by French authorities. (A.C.)

  16. Solution structure of a Plasmodium falciparum AMA-1/MSP 1 chimeric protein vaccine candidate (PfCP-2.9 for malaria

    Directory of Open Access Journals (Sweden)

    Jin Changwen

    2010-03-01

    Full Text Available Abstract Background The Plasmodium falciparum chimeric protein PfCP-2.9 is a promising asexual-stage malaria vaccine evaluated in clinical trials. This chimeric protein consists of two cysteine-rich domains: domain III of the apical membrane antigen 1 (AMA-1 [III] and the C-terminal region of the merozoite surface protein 1 (MSP1-19. It has been reported that the fusion of these two antigens enhanced their immunogenicity and antibody-mediated inhibition of parasite growth in vitro. Methods The 15N-labeled and 13C/15N-labeled PfCP-2.9 was produced in Pichia pastoris for nuclear magnetic resonance (NMR structure analysis. The chemical shift assignments of PfCP-2.9 were compared with those previously reported for the individual domains (i.e., PfAMA-1(III or PfMSP 1-19. The two-dimensional spectra and transverse relaxation rates (R2 of the PfMSP1-19 alone were compared with that of the PfCP-2.9. Results Confident backbone assignments were obtained for 122 out of 241 residues of PfCP-2.9. The assigned residues in PfCP-2.9 were very similar to those previously reported for the individual domains. The conformation of the PfMSP1-19 in different constructs is essentially the same. Comparison of transverse relaxation rates (R2 strongly suggests no weak interaction between the domains. Conclusions These data indicate that the fusion of AMA-1(III and MSP1-19 as chimeric protein did not change their structures, supporting the use of the chimeric protein as a potential malaria vaccine.

  17. CARRYING OF FRENCH VISAS FOR HOLDERS OF CATEGORY 'EF' FRENCH ATTESTATIONS DE FONCTIONS

    CERN Multimedia

    Service des Relations avec les Pays Hôtes

    1999-01-01

    The French Ministry of Foreign Affairs has informed the Organisation that members of the personnel resident in Switzerland and holding Category 'EF' French Attestations de functions are not obliged to be in possession of French visas. When temporarily travelling through France on OFFICIAL CERN BUSINESS, provided they are carrying the valid Attestation and a valid national passport with them.Relations with the Host States Servicehttp://www.cern.ch/relations/Tel. 72848

  18. [The French medecine pricing committee].

    Science.gov (United States)

    Giorgi, D

    2017-09-01

    The French medicine pricing committee (CEPS) has to reconcile several major constraints, including optimal patient access to medicines and a good control of expenditures on reimbursable medicines. From 2013 to 2015, drug price decreases and discounts obtained by CEPS contributed more than € 5 billion to the balance of the health insurance accounts. As for price setting, there is a significant drop in the prices of medicines in France once they are registered for reimbursement. France is affected by a limited, but costly, flow of innovative medicines, whose prices are higher than those of previous generations, a reflection of an international gradient to which France is obviously subject, despite prices that remain at the low end of the range in Western Europe. The provision of innovative medicines for all patients who need them has been ensured in France over the last fifteen years at a controlled cost. But with the arrival of new expensive products, a resolute policy of control of expenditures must take over from the fall in prices, and original financing channels will have to be explored. Copyright © 2017 Académie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.

  19. Nuclear transparency: the French example

    International Nuclear Information System (INIS)

    Phuc Tran Dai

    2016-01-01

    In France nuclear industry is from far the industrial sector that has set the most numerous commissions that allow a dialogue with the public in order to favor transparency. There are 4 local structures of information: -)there are 38 Local Committees of Information (CLI) associated with nuclear facilities, -) the Information Committees (CI) associated with secret nuclear facilities, -) the Follow-up Committees (CSS) for facilities dedicated to the processing of wastes, and the Committees for the prevention of industrial pollution (SPPPI). These committees involve numerous actors: public service, industrialists, supervisory authorities, elected representatives, employee representatives, members of associations and residents living nearby. Since 2000, 10 national public hearings around the 'atom' have been organized by the CNDP (National Commission for Public Consultation). Most actors of the nuclear industry allow residents living nearby to visit their installations, EDF ranks 3 as the company most visited with 400.000 people a year. Following the nuclear example the French chemical industry progressively moves toward more transparency. (A.C.)

  20. New generation of French ISIM

    International Nuclear Information System (INIS)

    Besse, J.; Cattiaux, G.; Clicques, J.; Landez, J.P.; Birac, A.M.; Benoist, P.; Viard, J.

    1986-11-01

    Up to now, 110 pre- or inservice inspections of PWR vessels have been performed both in France and aboard by the mean of the first generation of french ISIM named MIS. Due to the increase of the number inspections which have to be realized in the next years, a new generation of ISIM have been developed. The first one is named MIS 5. The general structure of the mechanical part of MIS has not been changed, some improvements have been introduced to take in account the experience and facilitate maintenance, mounting, dismounting and transportation. The main changes lie in the control system and data acquisition and analysis equipment. The versatility of computers is widely used. A parametrizing unit allows to set all the parameters both for the tools and for the ultrasonic equipment and the data acquisition system. The ultrasonic equipment is able of managing 32 channels. Data are recorded simultaneously on Winchester disk, bulk memory and cassette of a HP 1000 computer (serial 900) and cassette. SOFTWARES have been developed by INTERCONTROLE for acquisition and analysis which allow to exhibit results automatically on screen printer or/and plotter. All the electronics and computer equipment are set in a shelter outside of the containement, linked to the MIS by 2 cables. 7 refs

  1. French natural gas industry statistics

    International Nuclear Information System (INIS)

    2004-01-01

    The opening of the French natural gas market is effective since August 2000. In this context, some information, which were published in the past, have become confidential and strategic and can no longer be revealed. The data published in this 2004 edition concern only the years 2001 and 2002 for which data are available. The year 2000 inquiry could not be exploited. A first part presents the natural gas industry in France (consumption, supplies, production, storage, distribution, definition of gases, information sources, energy equivalence, map of transportation networks, storage, compression and production facilities). The statistical data are summarized in the second part in the form of tables: resources and uses in 1999, 2001 and 2002; sectoral use of the network distributed gas since 1972; regional distribution of gas production; domestic production and imports since 1972; sectoral distribution of network gas supplies; pipelines and distribution systems; personnel in the gas industry; gas supplies in 2002; supplies to the residential-tertiary sector in 2002; supplies to the industry in 2002; regional supplies in 2002; share of gas supplies per use in each region; regional distribution of gas supplies for each use. A comparison between the 2002 inquiry results and the provisional status is given in appendix. The 2002 energy status and the 2002 questionnaire are also given in appendixes. (J.S.)

  2. A French fuel cell prototype

    International Nuclear Information System (INIS)

    Anon.

    2001-01-01

    A French prototype of a fuel cell based on the PEM (proton exchange membrane) technology has been designed by Helion, a branch of Technicatome, this fuel cell delivers 300 kW and will be used in naval applications and terrestrial transport. The main advantages of fuel cell are: 1) no contamination, even if the fuel used is natural gas the quantities of CO 2 and CO emitted are respectively 17 and 75 times as little as the maximal quantities allowed by European regulations, 2) efficiency, the electric yield is up to 60 % and can reach 80 % if we include the recovery of heat, 3) silent, the fuel cell itself does not make noise. The present price of fuel cell is the main reason that hampers its industrial development, this price is in fact strongly dependant on the cost of its different components: catalyzers, membranes, bipolar plates and the hydrogen supply. This article gives the technical characteristics of the Helion's fuel cell. (A.C.)

  3. Opening of the French gas market

    International Nuclear Information System (INIS)

    Tordjman, F.; Vivies, P. de; Pariente-David, S.; Zagury, Ph.; April, F.; Guenaire, M.; Greiveldinger, H.; Rottenberg, J.; Lemaire, Ch.; Gentou, H.; Lesaffre, Th.; Besnault, J.; Martin, S.; Mouton, F.R.; Boulanger, Ph.

    2003-05-01

    The following topics are discussed: the national and european regulation framework; the french market opening forms; the impacts (purchase policy) on the actors (big industrial groups) and the contracts. (A.L.B.)

  4. The French civilian nuclear: connections and stakes

    International Nuclear Information System (INIS)

    2010-01-01

    This document (18 power point slides) gives an overview of the French civilian nuclear industry and research and development: importance of the nuclear power generation in France, excellence of the education in nuclear sciences, organization of the nuclear connection (CEA, Areva, EDF, IRSN), the role of the French International Nuclear Agency (AFNI), the requirements for a renewal of human resources (French and foreign engineers) in the field of nuclear energy, the degree course for a diploma, examples of engineer and university diplomas, the educational networks in various regions of France, presentation of the Institut National des Sciences et Techniques Nucleaires (Nuclear Sciences and Techniques National Institute) and its master degrees, organization of the French education system in nuclear sciences with strong relations with the research and development programs

  5. language teacher recruitment in the French

    African Journals Online (AJOL)

    We first present the broad lines of the French system of language teacher recruitment in ... Hebrew, Italian, Japanese, Portuguese, Russian, Swedish, Spanish, Turkish and .... knowledge and learning ability), the higher the Department's.

  6. Introduction Robin Melrose The French philosopher Jacques ...

    African Journals Online (AJOL)

    and presumably based on the present participle diff erant. (from differer), which in French means ... grammatical items that can fill the determiner slot). But ... or opposition which gives them form [ ... ] Here the ..... Here is a simple example from ...

  7. French bank mergers and acquisitions performance

    Directory of Open Access Journals (Sweden)

    Houda Ben Said

    2017-11-01

    Full Text Available In this paper, we empirically investigate the impact of mergers and acquisitions on French bank performance. Performance is measured by potential gains in efficiency and value creation. We first analyzed efficiency using the data envelopment analysis (DEA under input oriented with variable returns to scale to obtain the efficiency scores. Second, we analyzed the impact on French bank value creation following mergers-acquisitions operations of a set of control variables (model 1 and explicative variables measuring strategic similarities between bidders and targets (model 2. The sample studied is composed of French bank mergers-acquisitions happening between 1996 and 2006 and implying one of the 14 greatest French banking groups. Empirical result showed that mergers and acquisitions have been traduced by an improvement in the overall efficiency by 17.82% and a shareholder value reduction by 5.14%

  8. Le Francais quand meme (French Nonetheless).

    Science.gov (United States)

    Delautier, Jean-Marie

    1983-01-01

    Political, attitudinal, and administrative problems of teaching compulsory foreign languages in Colombia are described and discussed from the point of view of a French teacher in a system characterized by confusion and lack of student interest. (MSE)

  9. Opening of the French gas market

    International Nuclear Information System (INIS)

    Syrota, J.

    2002-01-01

    A report on the opening of the French gas market has been established, on the request of both the French minister of economy, finances and industry and the state secretary of industry, as expressed in their respective letters addressed to the president of the commission of electric power regulation (CRE). This report follows the step report on the opening of the French gas market published on January 15, 2002. It presents a status of the French gas market since August 2000, date of the enforcement of the European Union directive 98/30/CE, and expresses some recommendations about the main questions that should fall into the field of the future gas regulation. This report was elaborated before the project of law relative to the energy markets and published on October 24, 2002. These recommendations will have to be adapted to the dispositions of the law. This article presents some excerpts of the synthesis report. (J.S.)

  10. Planthopper pests of grapevine (in French)

    Science.gov (United States)

    In the French vineyards occur two main insect pests belonging to Fulgoromorpha, Hyalesthes obsoletus Signoret (Cixiidae) and Metcalfa pruinosa (Say) (Flatidae). Hyalesthes obsoletus is inducing economic losses by transmitting a phytoplasma, called Stolbur, from wild plants (bindweed, nettle, etc.) t...

  11. developing french for specific purposes in the nigerian university ...

    African Journals Online (AJOL)

    Ada

    Following the changing role of the French Language from a vehicle of French culture to a vehicle of Science, Technology, Commerce and Diplomacy, the teaching of French as a foreign language (FFL) around the world has shifted emphasis from literary studies to what has come to be known as French for Specific Purposes ...

  12. Status of French breeder development and German-French cooperation

    International Nuclear Information System (INIS)

    Vendryes, G.

    1978-01-01

    The development of fast breeder reactors in France is at present characterized by the successful operation of the 250 MW reactor, Phenix, and the speedy progress made in construction of the 1200 MW Superphenix plant. The technical concept of Superphenix is a logical extension of the Phenix concept, i.e., the pool type sodium cooled breeder reactor. While the only change in the primary system has been an increase in capacity, the main modification over Phenix is the change from small modular steam generators to four large units. The development of the work to date does not cast any doubt upon the envisaged date of first criticality in the second half of 1982. The basis of German-French cooperation is a joint declaration by the then Ministers for Research of the two countries on February 13, 1976 in which the Ministers had expressed themselves in favor of close cooperation between both countries in the development of safe, reliable and economic fast breeder reactors. On this basis, the two governments, the research centers and the industrial partners in the two countries, including the previous partners in Belgium, the Netherlands and Italy, agreed on the general principles of this cooperation. Meanwhile, the cooperation formalized in 1977 has been activated. Both in research and development and among planning and building industries the exchange of know-how and cooperation is in full swing. The joint company, SERENA, is the pool for the know-how introduced by the partners and the sole representative of the partners in the scheme. (orig.) 891 UA [de

  13. Unforgettable French Memory Tricks to Help You Learn and Remember French Grammar

    CERN Document Server

    Rice-Jones, Maria

    2010-01-01

    Unforgettable French uses memory tricks to teach and reinforce major points of rench grammar from the basics up to high school level, to learners of all ages. It may be used: by anyone who wishes to gain confidence in speaking French, as a evision aid, to consolidate the learner's grasp of grammatical points, to complement whatever French scheme you are using, and by French teachers at all levels, from elementary school through to adult. These tried-and-tested memory tricks help to explain "tri

  14. Approaching French Language Literature in Canadian Studies

    OpenAIRE

    Mansfield, Charlie

    2005-01-01

    This book forms a self-study pack and teaching guide to help English speakers start using computers and the web to support their studies of French Canadian Literature, song, film and multimedia. Readers will need access to the Internet so that they can experience ‘Electronic Encounters’ with Canadian media in French and English. The approach is underpinned with ideas drawn from the analysis of travel writing.

  15. Activating teaching methods in french language teaching

    OpenAIRE

    Kulhánková, Anna

    2009-01-01

    The subject of this diploma thesis is activating teaching methods in french language teaching. This thesis outlines the issues acitvating teaching methods in the concept of other teaching methods. There is a definition of teaching method, classification of teaching methods and characteristics of each activating method. In the practical part of this work are given concrete forms of activating teaching methods appropriate for teaching of french language.

  16. French strategy for green finance. Executive summary

    International Nuclear Information System (INIS)

    Lemmet, Sylvie; Ducret, Pierre; Berthaud, Cecilia; Evain, Julie; Scolan, Maria

    2017-12-01

    The authors present their report on the French Strategy for Green Finance. Green finance has expanded rapidly since 2015 but much remains to be done to make capital flows consistent with the goals of the Paris Agreement. France can continue to play a pioneering role to promote the energy and ecological transition, and to support Paris's role as a financial centre. The task force is putting forward recommendations along four axes for a French strategy to foster green finance

  17. French effort in field NDT nuclear plant

    International Nuclear Information System (INIS)

    Saglio, R.

    1983-12-01

    For the in-service inspection of nuclear generating stations, the French Atomic Commission has built up a program first to increase the defect detection probability, secondly to increase the reliability and recently to improve the characterization of defects. Focused Ultrasound and multiple frequency eddy current techniques, developped by French Atomic Energy Commission are well known. In this paper we will present the latest developments made in relation with defect characterization

  18. French in the XX Century: Development Tendencies

    Directory of Open Access Journals (Sweden)

    Taisiya I. Skorobogatova

    2017-06-01

    Full Text Available This article is devoted to the disclosure of changes that occurred in the French language in the XX century. The task of the authors is to present the main features characteristic of the French language of the 20th century, taking into account external history and to give their perspective assessment. World wars, the development of communication tools and the creation of new technologies, the strengthening of cultural and economic ties between France and other countries of the world had a significant impact on the evolution of the French language. Important results of the development of the French language in the period under review include: fixing a new phoneme [ŋ] in the consonantial system of the French language; enrichment of the lexical system at the expense of internal resources and at the expense of other languages; strengthening the dynamics of the development of the non-literary part of the language; increase in the number of syntactic Anglicisms. In general, the authors of the article attempted to give a detailed answer to the question: if there was the impoverishment of the French language in the twentieth century.

  19. [The medical French-speaking world].

    Science.gov (United States)

    Gouazé, André

    2002-01-01

    Medicine has always been and remains the most solid base of the French-speaking world which was born in Africa and Indochina with the admirable action of "colonial" military physicians, the implantation of the Pasteur Institutes and the emergence of resulting overseas medical schools. Obviously, we are referring to the French-speaking medical world. Since the first International Conference of the Deans of French-Speaking Medical Schools in Abidjan in 1981, today medical schools from 40 French-speaking countries participate. The conference undertakes co-operative medical school initiatives in a multi-lateral spirit, comprised by concrete, practical actions to assist universities in developing countries strive for excellence. These actions, which are conducted with the help of both institutional (AUF, MAE, WHO, UNESCO) and private partners mainly concentrate on promoting medical education of medicine, the evaluation of medical schools, the development of scientific and technical information and training teachers in the methodology of scientific clinical research and in public health. For the future, the Conference has three important objectives, to assist in training researchers and consequently in the development of research centres in emerging countries, to promote continuing medical education in rural areas far from medical schools by taking advantage of modern computer technology, and finally to open horizons toward other communities which speak other languages, and first of all, towards non French-speaking countries who live in a French-speaking environment.

  20. Complications and fixation techniques of trochanteric fractures with the TARGON(®) PF.

    Science.gov (United States)

    Takigawa, Naohide; Moriuchi, Hiromitsu; Abe, Muneki; Yasui, Kenji; Eshiro, Hisako; Kinoshita, Mitsuo

    2014-01-01

    The purpose of this study was to analyse clinical results of elderly patients with trochanteric fractures that were treated with use of TARGON(®) PF nail. Overall, 494 patients (113 males) were available for this study. On the basis of Jensen classification, there were 76 cases in type I, 164 cases in type II, 70 in type III, 129 in type IV and 55 in type V. (1) Sliding amount of lag screw in relation to the Jensen classification, (2) sliding amount of lag screw according to the Ikuta's classification that categorises the reduction in lateral view in three, Subtype A, Subtype N and Subtype P, (3) sliding amount of lag screw in correlation between Jensen classification and Ikuta's classification and (4) postoperative complications (9 cases; 1.7%) were assessed. Cut-out and back-out cases were seen in 6 cases (1.1%), and these severe complications were evaluated in details. In correlation between Jensen classification and Ikuta's classification, the excessive sliding of lag screw was prominent with the Subtype P, which was preoperatively in Jensen type III or V. Cut-out or back-out cases were caused either from (1) Subtype P that were preoperatively Jensen types III or V, or from (2) the fracture where there was bony defect anteriorly. Therefore, special care must be taken for these types. Copyright © 2013 Elsevier Ltd. All rights reserved.

  1. Los Alamos County Fire Department LAFD: TA-55 PF-4 Facility Familiarization Tour, OJT 55260

    Energy Technology Data Exchange (ETDEWEB)

    Rutherford, Victor Stephen [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-07-13

    Los Alamos National Laboratory (LANL) will conduct familiarization tours for Los Alamos County Fire Department (LAFD) personnel at the Plutonium Facility (PF-4) at Technical Area (TA)-55. These familiarization tours are official LANL business; the purpose of these tours is to orient the firefighters to the facility so that they can respond efficiently and quickly to a variety of emergency situations. This orientation includes the ingress and egress of the area and buildings, layout and organization of the facility, evacuation procedures and assembly points, and areas of concern within the various buildings at the facility. LAFD firefighters have the skills and abilities to perform firefighting operations and other emergency response tasks that cannot be provided by other LANL personnel who have the required clearance level. This handout provides details of the information, along with maps and diagrams, to be presented during the familiarization tours. The handout will be distributed to the trainees at the time of the tour. A corresponding checklist will also be used as guidance during the familiarization tours to ensure that all required information is presented to LAFD personnel.

  2. Studies of plasma interactions with tungsten targets in PF-1000U facility

    Directory of Open Access Journals (Sweden)

    Ladygina Maryna S.

    2016-06-01

    Full Text Available This paper presents results of experimental studies of tungsten samples of 99.95% purity, which were irradiated by intense plasma-ion streams. The behaviour of tungsten, and particularly its structural change induced by high plasma loads, is of great importance for fusion technology. The reported measurements were performed within a modified PF-1000U plasma-focus facility operated at the IFPiLM in Warsaw, Poland. The working gas was pure deuterium. In order to determine the main plasma parameters and to study the behaviour of impurities at different instants of the plasma discharge, the optical emission spectroscopy was used. The dependence of plasma parameters on the initial charging voltage (16, 19 and 21 kV was studied. Detailed optical measurements were performed during interactions of a plasma stream with the tungsten samples placed at the z-axis of the facility, at a distance of 6 cm from the electrode outlets. The recorded spectra showed distinct WI and WII spectral lines. Investigation of a target surface morphology, after its irradiation by intense plasma streams, was performed by means of an optical microscope. The observations revealed that some amounts of the electrodes material (mainly copper were deposited upon the irradiated sample surface. In all the cases, melted zones were observed upon the irradiated target surface, and in experiments performed at the highest charging voltage there were formed some cracks.

  3. Posttest analysis of MIST Test 330302 using TRAC-PF1/MOD1

    International Nuclear Information System (INIS)

    Boyack, B.E.

    1992-09-01

    This report discusses a posttest analysis of Multi-Loop Integral System Test (MIST) 330302 which has been performed using TRAC-PF1/MOD1. This test was one of group performed in the MIST facility to investigate high-pressure injection (HPI)-power-operated relief valve (PORV) cooling, also known as feed-and-bleed cooling. In Test 330302, HPI cooling was delayed 20 min after opening and locking the PORV open to induce extensive system voiding. We have concluded that the TRAC-calculated results are in reasonable overall agreement with the data for Test 330302. All major trends and phenomena were correctly predicted. Differences observed between the measured and calculated results have been traced and related, in part, to deficiencies in our knowledge of the facility configuration and operation. We have identified two models forwhich additional review is appropriate. However, in general, the TRAC closure models and correlations appear to be adequate for the prediction of the phenomena expected to occur during feed-and-bleed transientsin the MIST facility. We believe that the correct conclusions about trends and phenomena will be reached if the code is used in similar applications. Conclusions reached regarding use of the code to calculate similar phenomena in full-size plants (scaling implications) and regulatory implications of this work are also presented

  4. The effects of pf grind quality on coal burnout in a 1 MW combustion test facility

    Energy Technology Data Exchange (ETDEWEB)

    Richelieu Barranco; Michael Colechin; Michael Cloke; Will Gibb; Edward Lester [University of Nottingham, Nottingham (United Kingdom). School of Chemical, Environmental and Mining Engineering, Nottingham Fuel and Energy Centre

    2006-05-15

    A study was carried out to determine the effect of pf particle size distribution on coal burnout propensity in a 1 MW pulverised fuel burner. The specific aim of the work was to assess the improvement in combustion performance achievable by retrofitting commercially available high performance static or dynamic classifiers to existing plants. Two coals were used and were selected as representative of extremes in fuel characteristics experienced by coal importing utilities in Europe. Each coal was fired in the unit at a range of grind sizes to determine the overall impact of a variable performance from a mill. The levels of unburnt carbon in the resultant flyashes for the two coals showed significantly different behaviour. For the higher volatile coal, the unburnt carbon was found to be insensitive to grind quality. However, the coarser grinds of the other coal produced significantly lower unburnt carbon than expected when compared with the finest grinds. Generally the results indicate that the installation of improved classification technology, leading to a finer product, will help to lower unburnt carbon levels. Nevertheless, further work will be necessary to establish the levels of diminishing returns for grind size, burnout performance and grind costs. 21 refs., 4 figs., 4 tabs.

  5. INCLUSION OF THE LATENT PERSONALITY VARIABLE IN MULTINOMIAL LOGIT MODELS USING THE 16PF PSYCHOMETRIC TEST

    Directory of Open Access Journals (Sweden)

    JORGE E. CÓRDOBA MAQUILÓN

    2012-01-01

    Full Text Available Los modelos de demanda de viajes utilizan principalmente los atributos modales y las características socioeconómicas como variables explicativas. También se ha establecido que las actitudes y percepciones influyen en el comportamiento de los usuarios. Sin embargo, las variables psicológicas del individuo condicionan la conducta del usuario. En este estudio se incluyó la variable latente personalidad, en la estimación del modelo híbrido de elección discreta, el cual constituye una buena alternativa para incorporar los efectos de los factores subjetivos. La variable latente personalidad se evaluó con la prueba psicométrica 16PF de validez internacional. El artículo analiza los resultados de la aplicación de este modelo a una población de empleados y docentes universitarios, y también propone un camino para la utilización de pruebas psicométricas en los modelos híbridos de elección discreta. Nuestros resultados muestran que los modelos híbridos que incluyen variables latentes psicológicas son superiores a los modelos tradicionales que ignoran los efectos de la conducta de los usuarios.

  6. RNAdualPF: software to compute the dual partition function with sample applications in molecular evolution theory.

    Science.gov (United States)

    Garcia-Martin, Juan Antonio; Bayegan, Amir H; Dotu, Ivan; Clote, Peter

    2016-10-19

    RNA inverse folding is the problem of finding one or more sequences that fold into a user-specified target structure s 0 , i.e. whose minimum free energy secondary structure is identical to the target s 0 . Here we consider the ensemble of all RNA sequences that have low free energy with respect to a given target s 0 . We introduce the program RNAdualPF, which computes the dual partition function Z ∗ , defined as the sum of Boltzmann factors exp(-E(a,s 0 )/RT) of all RNA nucleotide sequences a compatible with target structure s 0 . Using RNAdualPF, we efficiently sample RNA sequences that approximately fold into s 0 , where additionally the user can specify IUPAC sequence constraints at certain positions, and whether to include dangles (energy terms for stacked, single-stranded nucleotides). Moreover, since we also compute the dual partition function Z ∗ (k) over all sequences having GC-content k, the user can require that all sampled sequences have a precise, specified GC-content. Using Z ∗ , we compute the dual expected energy 〈E ∗ 〉, and use it to show that natural RNAs from the Rfam 12.0 database have higher minimum free energy than expected, thus suggesting that functional RNAs are under evolutionary pressure to be only marginally thermodynamically stable. We show that C. elegans precursor microRNA (pre-miRNA) is significantly non-robust with respect to mutations, by comparing the robustness of each wild type pre-miRNA sequence with 2000 [resp. 500] sequences of the same GC-content generated by RNAdualPF, which approximately [resp. exactly] fold into the wild type target structure. We confirm and strengthen earlier findings that precursor microRNAs and bacterial small noncoding RNAs display plasticity, a measure of structural diversity. We describe RNAdualPF, which rapidly computes the dual partition function Z ∗ and samples sequences having low energy with respect to a target structure, allowing sequence constraints and specified GC

  7. LiPF{sub 6}. Synthesis and stability in EC/DMC and PC/DMC mixtures; LiPF{sub 6}. Synthese et stabilite dans les melanges EC/DMC et PC/DMC

    Energy Technology Data Exchange (ETDEWEB)

    Naejus, R.; Coudert, R.; Lemordant, D. [Laboratoire P.I.M.I.R. EA, Sciences et Techniques, 37 - Tours (France); Willmann, P. [CNES, 31 - Toulouse (France)

    1996-12-31

    Lithium hexa-fluoro-phosphate LiPF{sub 6} is recommended for the replacement of the toxic LiAsF{sub 6} and the explosive perchlorates (like LiClO{sub 4}) in rechargeable lithium electrochemical generators. The aim of this work is to develop a new method of synthesis of this salt and to check its stability with respect to carbonated solvents: ethylene carbonate (EC), propylene carbonate (PC) and dimethyl-carbonate (DMC) in already optimized EC/DMC and PC/DMC binary mixtures. Two methods using HPF{sub 6} are proposed: the first one uses the direct neutralization of this commercial acid by LiOH in aqueous, alcoholic or acetonitrile environment, while in the second one LiPF{sub 6} is obtained from pyridinium hexa-fluoro-phosphate synthesized from HPF{sub 6} using a new and simple protocol. (J.S.) 24 refs.

  8. LiPF{sub 6}. Synthesis and stability in EC/DMC and PC/DMC mixtures; LiPF{sub 6}. Synthese et stabilite dans les melanges EC/DMC et PC/DMC

    Energy Technology Data Exchange (ETDEWEB)

    Naejus, R; Coudert, R; Lemordant, D [Laboratoire P.I.M.I.R. EA, Sciences et Techniques, 37 - Tours (France); Willmann, P [CNES, 31 - Toulouse (France)

    1997-12-31

    Lithium hexa-fluoro-phosphate LiPF{sub 6} is recommended for the replacement of the toxic LiAsF{sub 6} and the explosive perchlorates (like LiClO{sub 4}) in rechargeable lithium electrochemical generators. The aim of this work is to develop a new method of synthesis of this salt and to check its stability with respect to carbonated solvents: ethylene carbonate (EC), propylene carbonate (PC) and dimethyl-carbonate (DMC) in already optimized EC/DMC and PC/DMC binary mixtures. Two methods using HPF{sub 6} are proposed: the first one uses the direct neutralization of this commercial acid by LiOH in aqueous, alcoholic or acetonitrile environment, while in the second one LiPF{sub 6} is obtained from pyridinium hexa-fluoro-phosphate synthesized from HPF{sub 6} using a new and simple protocol. (J.S.) 24 refs.

  9. French steam generator design developments

    International Nuclear Information System (INIS)

    Ginier, R.; Campan, J.L.; Pontier, M.; Leridon, A.; Remond, A.; Castello, G.; Holcblat, A.; Paurobally, H.

    1986-01-01

    From the outset of the French nuclear power program, a significant R and D effort has been invested in improvement of the design and operation of Pressurized Water Reactors including a special committment to improving steam generators. The steam generator enhancement program has spawned a wide variety of specific R and D resources, e.g., low temperature hydraulic models for investigation of areas with single-phase flow, and freon-filled models for simulation of areas of steam generators experiencing two-phase flow (tube bundles and moisture separators). For the moisture separators, a large scale research program using freon-filled models and highly sophisticated instrumentation was used. Tests at reactor sites during startup of both 900 MWe and 1300 MWe have been used to validate the assumptions made on the basis of loop tests. These tests also demonstrated the validity of using freon to simulate two-phase flow conditions. The wealth of knowledge accumulated by the steam generator R and D program has been used to develop a new design of steam generators for the N4 plants. The current R and D effort is aimed at qualifying the N4 steam generator model and developing more comprehensive models. One prong of the R and D effort is the Megeve program. Megeve is a 25 MW steam generator which simulates operating conditions of the N4 model. The other prong is Clotaire, a freon-filled steam generator model which will be used to qualify thermal/hydraulic design codes used for multidimensional calculations for design of tube bundles

  10. The Malaria Parasite Cyclin H Homolog PfCyc1 Is Required for Efficient Cytokinesis in Blood-Stage Plasmodium falciparum.

    Science.gov (United States)

    Robbins, Jonathan A; Absalon, Sabrina; Streva, Vincent A; Dvorin, Jeffrey D

    2017-06-13

    All well-studied eukaryotic cell cycles are driven by cyclins, which activate cyclin-dependent kinases (CDKs), and these protein kinase complexes are viable drug targets. The regulatory control of the Plasmodium falciparum cell division cycle remains poorly understood, and the roles of the various CDKs and cyclins remain unclear. The P. falciparum genome contains multiple CDKs, but surprisingly, it does not contain any sequence-identifiable G 1 -, S-, or M-phase cyclins. We demonstrate that P. falciparum Cyc1 (PfCyc1) complements a G 1 cyclin-depleted Saccharomyces cerevisiae strain and confirm that other identified malaria parasite cyclins do not complement this strain. PfCyc1, which has the highest sequence similarity to the conserved cyclin H, cannot complement a temperature-sensitive yeast cyclin H mutant. Coimmunoprecipitation of PfCyc1 from P. falciparum parasites identifies PfMAT1 and PfMRK as specific interaction partners and does not identify PfPK5 or other CDKs. We then generate an endogenous conditional allele of PfCyc1 in blood-stage P. falciparum using a destabilization domain (DD) approach and find that PfCyc1 is essential for blood-stage proliferation. PfCyc1 knockdown does not impede nuclear division, but it prevents proper cytokinesis. Thus, we demonstrate that PfCyc1 has a functional divergence from bioinformatic predictions, suggesting that the malaria parasite cell division cycle has evolved to use evolutionarily conserved proteins in functionally novel ways. IMPORTANCE Human infection by the eukaryotic parasite Plasmodium falciparum causes malaria. Most well-studied eukaryotic cell cycles are driven by cyclins, which activate cyclin-dependent kinases (CDKs) to promote essential cell division processes. Remarkably, there are no identifiable cyclins that are predicted to control the cell cycle in the malaria parasite genome. Thus, our knowledge regarding the basic mechanisms of the malaria parasite cell cycle remains unsatisfactory. We

  11. French participation in the world energy council

    International Nuclear Information System (INIS)

    Carouge, Ch.; Roussely, F.; Francony, M.; Ailleret, F.; Bosseboeuf, D.; Moisan, F.; Villaron, Th.

    1999-01-01

    The Revue de l'Energie is presenting the most influential French interventions at the 17. Congress of the World Energy Council held in September 1998 in Houston, (USA). These represent only part of French participation in the congress since a total of 16 individuals from France took part in the various sessions. Their presentations cover very varied topics and are one of the things that testify to the interest that our energy industries have in the works and operations of the WEC. Some other figures also bear witness to this interest: 184 French congress members, which is one of the largest delegations after that of the United States, the host country of the congress; 11 technical presentation, covering a wide range of subjects: from the nuclear reactor of the future to the use of bagasse (cane trash) for the production of electricity, from the underground storage of natural gas to the production of extra-heavy crude petroleum. The technical exhibition associated to the Congress was a great success and there again the French presence was able to make its mark: five exhibitors were gathered in the France of 600 m 2 , the most sizeable non-American national area.But French participation in the work of the WEC is not limited to congresses. The French Energy Council [Conseil francais de l'Energie] is careful to ensure its presence both in the formal proceedings of the WEC and within the studies undertaken under its three-year programme. This active French presence is also essential in order to defend the official English-French bilingualism of the World Energy Council. In spite of the good will of the organizers and the support of the general secretary's office in London, the Houston Congress showed how difficult it was to maintain the use of the French language on English-speaking territory. This is a difficult task, one that has to be undertaken anew each time, but one that France and other French-speaking nations have decided to pursue to the end. (authors)

  12. Investigation on Polylactide (PLA)/Poly(butylene adipate-co-terephthalate) (PBAT)/Bark Flour of Plane Tree (PF) Eco-Composites

    Science.gov (United States)

    Dou, Qiang; Cai, Jun

    2016-01-01

    Polylactide (PLA)/poly(butylene adipate-co-terephthalate) (PBAT)/bark flour of plane tree (PF) eco-composites were prepared via melt blending. The morphologies, mechanical properties, crystal structures and melting and crystallization behaviors of the eco-composites were investigated by means of scanning electron microscopy (SEM), mechanical tests, polarized light microscopy (PLM), wide angle X-ray diffraction (WAXD) and differential scanning calorimetry (DSC), respectively. It is shown that the interfacial adhesion between PLA matrix and PF is weak and the mechanical properties of PLA/PF eco-composites are poor. The titanate treatment improves the adhesion between the matrix and the filler and enhances the stiffness of the eco-composites. The toughness is improved by PBAT and ductile fractured surfaces can be found. The spherulitic size of PLA is decreased by the addition of PF. The α crystalline form of PLA remains in the composites. Compared with PF, T-PF (PF treated by a titanate coupling agent) and PBAT have negative effects on the crystallization of PLA. PMID:28773515

  13. Post-test analysis of semiscale large-break test S-06-3 using TRAC-PF1

    International Nuclear Information System (INIS)

    Boyack, B.E.

    1982-01-01

    The Transient Reactor Analysis Code (TRAC) is an advanced systems code for light-water-reactor accident analysis. The code was developed originally to analyze large-break loss-of-coolant accidents (LOCAs) and running time was not a primary development criterion. TRAC-PF1 was developed because increased application of the code to long transients such as small-break LOCAs required a faster-running code version. Although developed for long transients, its performance on large-break transients is still important. This paper assesses the ability of TRAC-PF1 to predict large-break-LOCA Test S-06-3 conducted in the Semiscale Mod-1 facility

  14. Dependence of CIT [Compact Ignition Tokamak] PF [poloidal field] coil currents on profile and shape parameters using the Control Matrix

    International Nuclear Information System (INIS)

    Strickler, D.J.; Peng, Y-K.M.; Jardin, S.C.; Pomphrey, N.

    1990-01-01

    The plasma shaping flexibility of the Compact Ignition Tokamak (CIT) poloidal field (PF) coil set is demonstrated through MHD equilibrium calculations of optimal PF coil current distributions and their variation with poloidal beta, internal inductance, plasma 95% elongation, and 95% triangularity. Calculations of the magnetic stored energy are used to compare solutions associated with various plasma parameters. The Control Matrix (CM) equilibrium code, together with the nonlinear equation and numerical optimization software packages HYBRD, and VMCON, respectively, are used to find equilibrium coil current distributions for fixed divertor geometry, volt-seconds, and plasma profiles in order to isolate the dependence on individual parameters. A reference equilibrium and coil current distribution are chosen, and correction currents dI are determined using the CM equilibrium method to obtain other specified plasma shapes. The reference equilibrium is the κ = 2 divertor at beginning of flattop (BOFT) with a minimum stored energy solution for the coil current distribution. The pressure profile function is fixed

  15. 216-Z-8 French drain characterization study

    International Nuclear Information System (INIS)

    Marratt, M.C.; Kasper, R.B.; Van Luik, A.E.

    1984-09-01

    The 216-Z-8 French drain study is one of a series of studies examining historical transuranic waste facilities no longer in use at the Hanford Site. The 216-Z-8 French drain underground disposal system consisted of a large settling tank that overflowed into a French drain. The French drain consisted of two large-diameter, gravel filled, vitrified clay pipes placed on end, end-to-end, over a gravel-filled excavation. The top of the drain was sealed with concrete to prevent the upward flow of waste solution. The waste solution discharged to the 216-Z-8 waste disposal system was a neutralized, transuranic recovery process, filter cake, backflush slurry. The primary objective of this study was to determine the distribution of plutonium and americium beneath the French drain. Transuranic activity under the French drain did not exceed 5 nCi/g in the soil samples obtained from a well within 1 m of the drain structure. Conservative estimates indicated that 4 to 5 m 3 of radioactive contaminated sediments, 10 nCi/g may lie directly under the 216-Z-8 French drain. The secondary objective of the study was to evaluate the possibility of a leak in the settling tank. Results from the analysis of soil samples from wells drilled around the settling tank indicated the presence of low-level transuranic contamination (on the order of 0.001 nci/g) in the soil surrounding the tank. However, the distribution of the contamination does not support a leak as a plausible mechanism to account for the observed activity surrounding the tank. The bulk of the plutonium was confirmed to be in the sludge that remained in the tank; thus, no significant environmental impact would be expected even if there has been a leak

  16. Biomass: towards more co-generation than gasification? Interview with Jean-Christophe Pouet; Figures for the heat fund; biomass in the Parisian heat network; gasification still at the promise stage; Engie bets on bio-methane of 2. generation; a new bidding for biomass co-generation

    International Nuclear Information System (INIS)

    Petitot, Pauline; De Santis, Audrey; Mary, Olivier; Signoret, Stephane

    2016-01-01

    After some brief presentations of some highlights in the biomass sector in France, Ukraine, UK and Brazil, a set of articles proposes an overview of recent developments and perspectives for the biomass-based energy and heat production in France. It presents and comments some emerging projects based on biomass gasification as technologies have evolved for a higher economic profitability. It discusses the action of the Heat Fund (Fonds chaleur) which supports investors in a context constrained by the hard competition with fossil energies, notably with gas as discussed in an interview with a member of the ADEME. Some tables and graphs give data about biomass installations supported by the Heat fund, about subsidies awarded by the ADEME, about the production of the various heat sources. An article comments the operation of a biomass-based plant near Paris which supplies the Parisian heat network. A project of methane production from dry biomass from local resources by Engie near Lyons (methane of second generation). The last article comments a new bidding process for co-generation projects which can be an opportunity for new projects, and not only big ones

  17. Hierarchies of Authenticity in Study Abroad: French from Canada versus French from France?

    Science.gov (United States)

    Wernicke, Meike

    2016-01-01

    For many decades, Francophone regions in Canada have provided language study exchanges for French as a second language (FSL) learners within their own country. At the same time, FSL students and teachers in Canada continue to orient to a native speaker standard associated with European French. This Eurocentric orientation manifested itself in a…

  18. Optimum use of CDOT French and Hamburg data (French and Hamburg tests).

    Science.gov (United States)

    2013-11-01

    The Colorado Department of Transportation (CDOT) has been collecting data from the Hamburg Rutter and the : French Rutter for over 20 years. No specifications have been written in that time for either the Hamburg Rutter : or the French Rutter. This r...

  19. Conductivity and thermopower studies of bis-tetramethyltetraselenafulvalenium hexafluorophosphide, bis-tetramethyltetrathiafulvalenium hexafluorophosphide, and their solid solutions, (TMTSF1-xTMTTFx)2PF6

    DEFF Research Database (Denmark)

    Mortensen, Kell; Engler, E. M.

    1984-01-01

    The conductivity σ and the thermoelectric power S have been studied experimentally on the organic conductors bis-tetramethyltetraselenafulvalenium hexafluorophosphide [(TMTSF)2PF6] and bis-tetramethyltetrathiafulvalenium hexafluorophosphide [(TMTTF)2PF6] and their solid solutions: (TMTSF1-xTMTTFx)2......PF6. Dramatic effects are seen in σ already when dilute concentrations of TMTTF molecules are introduced in the TMTSF chains, and for x=0.1, σ shows generally activated behavior. The thermopower, on the contrary, remains basically unaffected for x at least as large as 0.25. These unusual findings...

  20. Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism

    Energy Technology Data Exchange (ETDEWEB)

    Chiu, Hsiu-Ju; Bakolitsa, Constantina; Skerra, Arne; Lomize, Andrei; Carlton, Dennis; Miller, Mitchell D.; Krishna, S. Sri; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L.; Clayton, Thomas; Deller, Marc C.; Duan, Lian; Feuerhelm, Julie; Grant, Joanna C.; Grzechnik, Slawomir K.; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Kozbial, Piotr; Kumar, Abhinav; Marciano, David; McMullan, Daniel; Morse, Andrew T.; Nigoghossian, Edward; Okach, Linda; Paulsen, Jessica; Reyes, Ron; Rife, Christopher L.; van den Bedem, Henry; Weekes, Dana; Xu, Qingping; Hodgson, Keith O.; Wooley, John; Elsliger, Marc-Andre; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A. (SLAC); (Michigan); (TU Munchen)

    2015-10-15

    The first structural representative of the domain of unknown function DUF2006 family, also known as Pfam family PF09410, comprises a lipocalin-like fold with domain duplication. The finding of the calycin signature in the N-terminal domain, combined with remote sequence similarity to two other protein families (PF07143 and PF08622) implicated in isoprenoid metabolism and the oxidative stress response, support an involvement in lipid metabolism. Clusters of conserved residues that interact with ligand mimetics suggest that the binding and regulation sites map to the N-terminal domain and to the interdomain interface, respectively.

  1. PF-1355, a mechanism-based myeloperoxidase inhibitor, prevents immune complex vasculitis and anti-glomerular basement membrane glomerulonephritis.

    Science.gov (United States)

    Zheng, Wei; Warner, Roscoe; Ruggeri, Roger; Su, Chunyan; Cortes, Christian; Skoura, Athanasia; Ward, Jessica; Ahn, Kay; Kalgutkar, Amit; Sun, Dexue; Maurer, Tristan S; Bonin, Paul D; Okerberg, Carlin; Bobrowski, Walter; Kawabe, Thomas; Zhang, Yanwei; Coskran, Timothy; Bell, Sammy; Kapoor, Bhupesh; Johnson, Kent; Buckbinder, Leonard

    2015-05-01

    Small vessel vasculitis is a life-threatening condition and patients typically present with renal and pulmonary injury. Disease pathogenesis is associated with neutrophil accumulation, activation, and oxidative damage, the latter being driven in large part by myeloperoxidase (MPO), which generates hypochlorous acid among other oxidants. MPO has been associated with vasculitis, disseminated vascular inflammation typically involving pulmonary and renal microvasculature and often resulting in critical consequences. MPO contributes to vascular injury by 1) catabolizing nitric oxide, impairing vasomotor function; 2) causing oxidative damage to lipoproteins and endothelial cells, leading to atherosclerosis; and 3) stimulating formation of neutrophil extracellular traps, resulting in vessel occlusion and thrombosis. Here we report a selective 2-thiouracil mechanism-based MPO inhibitor (PF-1355 [2-(6-(2,5-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide) and demonstrate that MPO is a critical mediator of vasculitis in mouse disease models. A pharmacokinetic/pharmacodynamic response model of PF-1355 exposure in relation with MPO activity was derived from mouse peritonitis. The contribution of MPO activity to vasculitis was then examined in an immune complex model of pulmonary disease. Oral administration of PF-1355 reduced plasma MPO activity, vascular edema, neutrophil recruitment, and elevated circulating cytokines. In a model of anti-glomerular basement membrane disease, formerly known as Goodpasture disease, albuminuria and chronic renal dysfunction were completely suppressed by PF-1355 treatment. This study shows that MPO activity is critical in driving immune complex vasculitis and provides confidence in testing the hypothesis that MPO inhibition will provide benefit in treating human vasculitic diseases. Copyright © 2015 by The American Society for Pharmacology and Experimental Therapeutics.

  2. Fungal-specific transcription factor AbPf2 activates pathogenicity in Alternaria brassicicola

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Yangrae; Ohm, Robin A. [US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA, 94598, USA; Grigoriev, Igor V. [US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA, 94598, USA; Srivastava, Akhil [Plant and Environmental Protection Sciences, University of Hawaii at Manoa, 3190 Maile Way, St John 317, Honolulu, HI, 96822, USA

    2013-05-24

    Alternaria brassicicola is a successful saprophyte and necrotrophic plant pathogen. To identify molecular determinants of pathogenicity, we created non-pathogenic mutants of a transcription factor-encoding gene, AbPf2. The frequency and timing of germination and appressorium formation on host plants were similar between the non-pathogenic abpf2 mutants and wild-type A. brassicicola. The mutants were also similar in vitro to wild-type A. brassicicola in terms of vegetative growth, conidium production, and responses to a phytoalexin, reactive oxygen species and osmolites. The hyphae of the mutants grew slowly but did not cause disease symptoms on the surface of host plants. Transcripts of the AbPf2 gene increased exponentially soon after wild-type conidia contacted their host plants . A small amount of AbPf2 protein, as monitored using GFP fusions, was present in young, mature conidia. The protein level decreased during saprophytic growth, but increased and was located primarily in fungal nuclei during pathogenesis. Levels of the proteins and transcripts sharply decreased following colonization of host tissues beyond the initial infection site. When expression of the transcription factor was induced in the wild-type during early pathogenesis, 106 fungal genes were also induced in the wild-type but not in the abpf2 mutants. Notably, 33 of the 106 genes encoded secreted proteins, including eight putative effector proteins. Plants inoculated with abpf2 mutants expressed higher levels of genes associated with photosynthesis, the pentose phosphate pathway and primary metabolism, but lower levels of defense-related genes. Our results suggest that AbPf2 is an important regulator of pathogenesis, but does not affect other cellular processes in A. brassicicola.

  3. Deuteration of acetanilides and other substituted aromatics using [Ir(COD)(Cy3P)(Py)]PF6 as catalyst

    International Nuclear Information System (INIS)

    Hesk, D.; Das, P.R.; Evans, B.

    1995-01-01

    Deuterium exchange labelling using [Ir(COD)(Cy 3 P)(Py)]PF 6 as catalyst and deuterium gas was studied on a number of substituted acetanilides. In most cases products containing deuterium ortho to the anilide group were obtained with a high degree of enrichment. With one exception no evidence for meta, para or anilide methyl labelling was seen. The catalyst was also effective in the ortho deuteration of acetophenone, benzophenone and the β-lactam containing compound Sch 48461. (Author)

  4. Efficacy of Pseudomonas fluorescens (Pf-CL145A) spray dried powder for controlling zebra mussels adhering to test substrates

    Science.gov (United States)

    Luoma, James A.; Severson, Todd J.; Weber, Kerry L.; Mayer, Denise A.

    2015-01-01

    A mobile bioassay trailer was used to assess the efficacy of Pseudomonas fluorescens (Pf-CL145A) spray dried powder (SDP) formulation for controlling zebra mussels (Dreissena polymorpha) from two midwestern lakes: Lake Carlos (Alexandria, Minnesota) and Shawano Lake (Shawano, Wisconsin). The effects of SDP exposure concentration and exposure duration on zebra mussel survival were evaluated along with the evaluation of a benthic injection application technique to reduce the amount of SDP required to induce zebra mortality.

  5. Understanding the thermal instability of fluoroethylene carbonate in LiPF6-based electrolytes for lithium ion batteries

    International Nuclear Information System (INIS)

    Kim, Koeun; Park, Inbok; Ha, Se-Young; Kim, Yeonkyoung; Woo, Myung-Heuio; Jeong, Myung-Hwan; Shin, Woo Cheol; Ue, Makoto; Hong, Sung You; Choi, Nam-Soon

    2017-01-01

    Highlights: • The FEC in LiPF 6 -based electrolytes thermally decomposes at elevated temperatures. • Lewis acids in the electrolyte promote de-fluorination of the FEC to form HF. • The HF causes the SEI destruction and severe metal ion dissolution from the cathode. - Abstract: The cycling and storage performances of LiCoO 2 (LCO)-LiNi 0.5 Co 0.2 Mn 0.3 O 2 (NCM)/pitch-coated silicon alloy-graphite (Si-C) full cells with ethylene carbonate (EC)–based and fluoroethylene carbonate (FEC)–based electrolytes are investigated at elevated temperatures. Excess FEC (used as a co-solvent in LiPF 6 -based electrolytes), which is not completely consumed during the formation of the solid electrolyte interphase (SEI) layer on the electrodes, is prone to defluorination in the presence of Lewis acids such as PF 5 ; this reaction can generate unwanted HF and various acids (H 3 OPF 6 , HPO 2 F 2 , H 2 PO 3 F, H 3 PO 4 ) at elevated temperatures. Our investigation reveals that the HF and acid compounds that are formed by FEC decomposition causes significant dissolution of transition metal ions (from the LCO-NCM cathode) into the electrolyte at elevated temperatures; as a result, the reversible capacity of the full cells reduces because of the deposition of the dissolved metal ions onto the anode. Moreover, we demonstrate possible mechanisms that account for the thermal instability of FEC in LiPF 6 -based electrolytes at elevated temperatures using model experiments.

  6. Electrochemical investigation of Li-Al anodes in oligo(ethylene glycol) dimethyl ether/LiPF6

    International Nuclear Information System (INIS)

    Zhou, Y.; Wang, X.; Lee, H.; Nam, K.; Haas, O.

    2011-01-01

    LiPF 6 dissolved in oligo(ethylene glycol) dimethyl ether with a molecular weight 5 g mol -1 was investigated as a new electrolyte (OEGDME5, 1 M LiPF 6 ) for metal deposition and battery applications. At 25 C a conductivity of .48 x 1 -3 S cm -1 was obtained and at 85 C, 3.78 x 1 -3 S cm -1 . The apparent activation barrier for ionic transport was evaluated to be 3.7 kJ mol -1 . OEGDME5, 1 M LiPF 6 allows operating temperature above 1 C with very attractive conductivity. The electrolyte shows excellent performance at negative and positive potentials. With this investigation, we report experimental results obtained with aluminum electrodes using this electrolyte. At low current densities lithium ion reduction and re-oxidation can be achieved on aluminum electrodes at potentials about 28 mV more positive than on lithium electrodes. In situ X-ray diffraction measurements collected during electrochemical lithium deposition on aluminum electrodes show that the shift to positive potentials is due to the negative Gibbs free energy change of the Li-Al alloy formation reaction.

  7. Conceptual design of PF coil system and operation scenario on inductively-operated day-long pulsed tokamak reactor

    International Nuclear Information System (INIS)

    Wang, J.F.; Yamamoto, T.; Ogawa, Y.

    1994-01-01

    It is said that disadvantages of pulsed operation in tokamak fusion reactor are fatigue problem of structural materials and an introduction of energy storage System to compensate the power during the dwell time. To overcome theses disadvantages the authors have designed an inductively-operated ultralong pulsed tokamak called (IDLT) reactor where plasma with a major radius of 10 m are employed so as to provide a magnetic flux necessary to sustain a plasma current inductively during 10 hours or more. This makes it possible to reduce the total cycle number to be around 10 4 during the life of the fusion plant. In pulsed operation reactors the shorter dwell time with a quick start-up and shut down of plasma is very convenient to realize a high availability of the power plant, but it will induce more severe conditions for the hardware design. The authors assumed the dwell time of 5∼10 minutes and analyzed the feasibility of plasma operation scenario for IDLT reactor, especially paying much attention to PF coil system. The stored energy of PF coil system becomes ∼100 GJ, which is comparable with that of toroidal field coil system. When the plasma current of 14 MA is ramped up with a time of 100 seconds, it is found that the maximum capacity of 1 GW is necessary for PF coil power supply. Engineering issues related with AC/hysterisis loss should be carefully examined

  8. Valproic Acid as a Potential Inhibitor of Plasmodium falciparum Histone Deacetylase 1 (PfHDAC1: An in Silico Approach

    Directory of Open Access Journals (Sweden)

    Mohamed A. Abdallah Elbadawi

    2015-02-01

    Full Text Available A new Plasmodium falciparum histone deacetylase1 (PfHDAC1 homology model was built based on the highest sequence identity available template human histone deacetylase 2 structure. The generated model was carefully evaluated for stereochemical accuracy, folding correctness and overall structure quality. All evaluations were acceptable and consistent. Docking a group of hydroxamic acid histone deacetylase inhibitors and valproic acid has shown binding poses that agree well with inhibitor-bound histone deacetylase-solved structural interactions. Docking affinity dG scores were in agreement with available experimental binding affinities. Further, enzyme-ligand complex stability and reliability were investigated by running 5-nanosecond molecular dynamics simulations. Thorough analysis of the simulation trajectories has shown that enzyme-ligand complexes were stable during the simulation period. Interestingly, the calculated theoretical binding energies of the docked hydroxamic acid inhibitors have shown that the model can discriminate between strong and weaker inhibitors and agrees well with the experimental affinities reported in the literature. The model and the docking methodology can be used in screening virtual libraries for PfHDAC1 inhibitors, since the docking scores have ranked ligands in accordance with experimental binding affinities. Valproic acid calculated theoretical binding energy suggests that it may inhibit PfHDAC1.

  9. Cycle stability of the electrochemical capacitors patterned with vertically aligned carbon nanotubes in an LiPF6-based electrolyte.

    Science.gov (United States)

    Chiou, Yi-Deng; Tsai, Dah-Shyang; Lam, Hoa Hung; Chang, Chuan-hua; Lee, Kuei-Yi; Huang, Ying-Sheng

    2013-09-07

    The miniature ultracapacitors, with interdigitated electrodes of vertically aligned carbon nanotubes (VACNTs) and an inter-electrode gap of 20 μm, have been prepared in the LiPF6 organic electrolyte with and without PVdF-HFP gel. PVdF-HFP between two opposing electrodes enhances the device reliability, but lessens its power performance because of the extra diffusion resistance. Also noteworthy are the gel influences on the cycle stability. When the applied voltage is 2.0 or 2.5 V, both the LiPF6 and the gel capacitors exhibit excellent stability, typified by a retention ratio of ≥95% after 10,000 cycles. Their coulombic efficiencies quickly rise up, and hold steady at 100%. Nonetheless, when the applied voltage is 3.5 or 4.0 V, the cycle stability deteriorates, since the negative electrode potential descends below 0.9 V (vs. Li), leading to electrolyte decomposition and SEI formation. For the LiPF6 capacitor, its retention ratio could be around 60% after 10,000 cycles and the coulombic efficiency of 100% is difficult to reach throughout its cycle life. On the other hand, the gel capacitor cycles energy with a much higher retention ratio, >80% after 10,000 cycles, and a better coulombic efficiency, even though electrolyte decomposition still occurs. We attribute the superior stability of the gel capacitor to its extra diffusion resistance which slows down the performance deterioration.

  10. TRAC-PF1 analyses of potential pressurized-thermal-shock transients at a Combustion-Engineering PWR

    International Nuclear Information System (INIS)

    Koenig, J.E.; Spriggs, G.D.; Smith, R.C.

    1984-01-01

    Los Alamos is participating in a program to assess the risk of pressurized thermal shock (PTS) to a reactor vessel. Our role is to provide best-estimate thermal-hydraulic analyses of 12 postulated overcooling transients using TRAC-PF1. These transients are hypothetical and include multiple operator/equipment failures. Calvert Cliffs/Unit-1, a Combustion-Engineering plant, is the pressurized water reactor modeled for this study. The utility and the vendor supplied information for the comprehensive TRAC-PF1 model. Secondary and primary breaks from both hot-zero-power and full-power conditions were simulated for 7200 s (2 h). Low bulk temperatures and loop-flow stagnation while the system was at a high pressure were of particular interest for PTS analysis. Three transients produced primary temperatures below 405 K (270 0 F - the NRC screening criterion) with system repressurization. Six transients indicated flow stagnation would occur in one loop but not both. One transient showed flow stagnation might occur in both loops. Oak Ridge National Laboratory will do fracture-mechanics analysis using these TRAC-PF1 results and make the final determination of the risk of PTS

  11. TRAC-PF1/MOD3 calculations of Savannah River Laboratory Rig FA single-annulus heated experiments

    International Nuclear Information System (INIS)

    Fischer, S.R.; McDaniel, C.K.

    1992-01-01

    This paper presents the results of TRAC-PF1/MOD3 benchmarks of the Rig FA experiments performed at the Savannah River Laboratory to simulate prototypic reactor fuel assembly behavior over a range of fluid conditions typical of the emergency cooling system (ECS) phase of a loss-of-coolant accident (LOCA). The primary purpose of this work was to use the SRL Rig FA tests to qualify the TRAC-PF1/MOD3 computer code and models for computing Mark-22 fuel assembly LOCA/ECS power limits. This qualification effort was part of a larger effort undertaken by the Los Alamos National Laboratory for the US Department of Energy to independently confirm power limits for the Savannah River Site K Reactor. The results of this benchmark effort as discussed in this paper demonstrate that TRAC/PF1/MOD3 coupled with proper modeling is capable of simulating thermal-hydraulic phenomena typical of that encountered in Mark-22 fuel assembly during LOCA/ECS conditions

  12. Progress in mass- and energy- analysis of ion beams emitted from RPI and PF-type discharges

    International Nuclear Information System (INIS)

    Czaus, K.; Skladnik-Sadowska, E.; Kwiatkowski, R.; Malinowski, K.; Zebrowski, J.; Sadowski, M.J.

    2013-01-01

    The paper describes progress in studies of ion beams generated and accelerated within RPI (Rod Plasma Injector) and PF (Plasma-Focus) devices. To perform mass- and energy-analysis of such ion beams the use was made of different mass-spectrometers of the Thomson type. Ion measurements in RPI-IBIS facility were first performed with a big Thomson analyzer placed outside the vacuum chamber. To perform ion measurements near the electrodes two other Thomson analyzers were constructed at IPJ (now NCBJ). A smaller analyzer was applied in a large PF-1000 facility at IFPiLM, and time-integrated ion parabolas were recorded on nuclear track detectors. That analyzer was also adopted for time-resolved measurements by means of miniature scintillation detectors located along the deuteron parabola and it was used in the RPI-IBIS facility. Recently the analyzer construction was modernized to ensure differential pumping of the inlet system, and it was used for measurements within PF-360 and RPI-IBIS facilities.

  13. A portion of the Pf155/RESA antigen of Plasmodium falciparum is accessible on the surface of infected erythrocytes

    International Nuclear Information System (INIS)

    Saul, A.; Maloy, W.L.; Howard, R.J.; Rock, E.P.

    1988-01-01

    An investigation of antigens accessible to lactoperoxidase-catalysed cell surface iodination on intact Plasmodium falciparum-infected red blood cells (RBC) has identified a 125 I-labelled antigen with an apparent size of about 155 kD. This labelled protein was specifically immunoprecipitated by the following antibodies: a rabbit antiserum and a mouse monoclonal antibody raised against a synthetic peptide comprising the 3',8-mer repeat EENVEHDA of the Pf155/RESA protein; a rabbit antiserum raised against a synthetic octapeptide comprising two copies of the 3',4-mer repeat EENV of the Pf155/RESA protein; and rabbit antisera against another synthetic peptide C(MYSNNNVED) 2 . The last antibody shows a strong reaction in asexual blood state parasites with the Pf155/RESA antigen. While this antigen has been described previously as a submembrane component of the outer membrane of infected RBC, this report shows that at least part of it is accessible to the surface of both ring and late trophozoite-infected erythrocytes. 21 refs., 4 figs

  14. Radioactivity and the French uranium bearing minerals

    International Nuclear Information System (INIS)

    Guiollard, P.Ch.; Boisson, J.M.; Leydet, J.C.; Meisser, N.

    1998-01-01

    This special issue of Regne Mineral journal is entirely devoted to the French uranium mining industry. It comprises 4 parts dealing with: the uranium mining industry in France (history, uranium rush, deposits, geologic setting, prosperity and recession, situation in 1998, ore processing); radioactivity and the uranium and its descendants (discovery, first French uranium bearing ores, discovery of radioactivity, radium and other uranium descendants, radium mines, uranium mines, atoms, elements and isotopes, uranium genesis, uranium decay, isotopes in an uranium ore, spontaneous fission, selective migration of radionuclides, radon in mines and houses, radioactivity units, radioprotection standards, new standards and controversies, natural and artificial radioactivity, hazards linked with the handling and collecting of uranium ores, conformability with radioprotection standards, radioactivity of natural uranium minerals); the French uranium bearing minerals (composition, crystal structure, reference, etymology, fluorescence). (J.S.)

  15. French dissatisfactions on the European electricity market

    International Nuclear Information System (INIS)

    Glachant, J.M.

    2007-01-01

    The author first notices that the French electricity professional consumers are dissatisfied with the results of the creation of the European domestic electricity market in 1997: price increase either on bills or on the wholesale markets, and even more price increases are to come. The author proposes to examine several issues: what has been done during the 6 or 7 past years, that is since the California crisis in 2000-2001, to put the European electrical reforms on a virtuous track? Have the basic market economy principles been respected to protect competitiveness of all energy consumer professionals? How and why the French government or EDF will make us pay gas, coal or CO 2 emission permits like in England or Germany whereas the French electricity production has mainly (90 or 95 per cent) a nuclear or hydraulic origin?

  16. Correspondence Theory and Phonological Blending in French

    Directory of Open Access Journals (Sweden)

    Lee Scott

    2014-07-01

    Full Text Available Though less productive than rival word-formation processes like compounding and affixation, blending is still a rich source of neologisms in French. Despite this productivity, however, blends are often seen by scholars as unpredictable, uninteresting, or both. This analysis picks up where recent studies of blending have left off, using Correspondence Theory and a bundle of segmental constraints to deal with this phenomenon as it pertains to French. More specifically, it shows that blending is the result of a single output standing in correspondence with two or more other outputs, and that we do not need to refer to prosodic information, which is crucial in accounts of blending in languages with lexical stress like English, to account for the process in French. The analysis also differs from previous studies in that it locates blending exclusively within the phonology, leaving its morphological and semantic characteristics to be handled by other processes in the grammar.

  17. Modelling of coupled self-actuating safety, relief and damped check valve systems with the codes TRAC-PF1 and ROLAST

    International Nuclear Information System (INIS)

    Neumann, U.; Puzalowski, R.; Grimm, I.

    1985-01-01

    Numerical valve models for simulation of selfactuating safety valves and damped check valves are introduced for the computer programs TRAC-PF1 and ROLAST. As examples of application post-test calculations and stability analysis are given. (orig.)

  18. Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects.

    Science.gov (United States)

    D'Souza, Deepak Cyril; Carson, Richard E; Driesen, Naomi; Johannesen, Jason; Ranganathan, Mohini; Krystal, John H

    2018-01-31

    Glycine transporter-1 (GlyT1) inhibitors may ameliorate cognitive impairments associated with schizophrenia. The dose-related occupancy and target engagement of the GlyT1 inhibitor PF-03463275 were studied to inform optimal dose selection for a clinical trial for cognitive impairments associated with schizophrenia. In substudy 1, the effects of PF-03463275 (10, 20, and 40 mg twice a day) on occupancy of GlyT1 were tested using positron emission tomography and 18 F-MK-6577, and visual long-term potentiation (LTP) in schizophrenia patients (SZs) and healthy control subjects. Furthermore, the capacity of PF-03463275 to attenuate ketamine-induced disruption of working memory-related activation of a "working memory" circuit was tested only in healthy control subjects using functional magnetic resonance imaging. Subsequently, the effects of PF-03463275 (60 mg twice a day) on occupancy of GlyT1 and long-term potentiation were examined only in SZs (substudy 2). PF-03463275 at 10, 20, 40, and 60 mg twice a day produced ∼44%, 61%, 76%, and 83% GlyT1 occupancy, respectively, in SZs with higher ligand binding to GlyT1 in subcortical versus cortical regions. PF-03463275 did not attenuate any ketamine-induced effects but did improve working memory accuracy in healthy control subjects. PF-03463275 increased long-term potentiation only in SZs with peak effects at 40 mg twice a day (∼75% GlyT1 occupancy) and with a profile suggestive of an inverted U dose response. PF-03463275 was well-tolerated. The dose-related GlyT1 occupancy of PF-03463275 is linear. While PF-03463275 did not show evidence of facilitating N-methyl-D-aspartate receptor function in the ketamine assay, it enhanced neuroplasticity in SZs. These findings provide support for a clinical trial to test the ability of PF-03463275 to enhance cognitive remediation toward addressing cognitive impairments associated with schizophrenia. Published by Elsevier Inc.

  19. Edexcel international GCSE and certificate French

    CERN Document Server

    Grime, Yvette

    2013-01-01

    This brand-new Student Book provides a grammar-led approach with extensive exam preparation that will help you develop independent, culturally aware students of French ready for the exam. The book is written to the latest Edexcel specification by experienced teachers. Extensive use of French reflects the style of the exams and, with specific exam advice and practice, it helps to build all the skills needed for success. Topics on Francophone cultures are integrated throughout to ensure students gain the cultural awareness that is at the heart of this qualification. The book provides up-to-date

  20. Characterisation of Chlorine Behavior in French Graphite

    International Nuclear Information System (INIS)

    Blondel, A.; Moncoffre, N.; Toulhoat, N.; Bererd, N.; Petit, L.; Laurent, G.; Lamouroux, C.

    2016-01-01

    Chlorine 36 is one of the main radionuclides of concern for French graphite waste disposal. In order to help the understanding of its leaching behaviour under disposal conditions, the respective impact of temperature, irradiation and gas radiolysis on chlorine release in reactor has been studied. Chlorine 36 has been simulated through chlorine 37 ion implantation in virgin nuclear graphite samples. Results show that part of chlorine is highly mobile in graphite in the range of French reactors operating temperatures in relation with graphite structural recovering. Ballistic damage generated by irradiation also promotes chlorine release whereas no clear impact of the coolant gas radiolysis was observed in the absence of graphite radiolytic corrosion. (author)

  1. French enterprises build on wind power

    International Nuclear Information System (INIS)

    Rap, C.

    2013-01-01

    Being confronted by the economic crisis French enterprises look for diversification towards sectors which appear to bear promise of growth. The wind industry is one of them despite the slowing demand for land-based installations. A wind turbine is made of 11 components which represents a total of 3000 parts. A series of French enterprises benefit from this market by specialising in narrow market niches like bearings, toothed wheels,... This document gathers short information notes on the following enterprises: SKF, Mersen, les Forges de Trie-Chateau, Guerton, Rollix, and NTN-SNR. (A.C.)

  2. Population distribution around French nuclear sites

    International Nuclear Information System (INIS)

    Bastien, M.C.

    1985-10-01

    With the help of two files respectively from the Institut geographique national (IGN) containing the geographic reference of all cities in France, and from the Institut national de la statistique et des etudes economiques (INSEE) containing the population figures of the 1982 census, the distribution of the population around a geographic point can be determined according to a given grid. Tables of population distribution around the 30 french nuclear sites were obtained by this method; however, at a short distance from a site, a detailed local examination/survey/investigation is necessary. Data shall have to be collected to estimate the non-french population around frontier sites [fr

  3. PF-03882845, a non-steroidal mineralocorticoid receptor antagonist, prevents renal injury with reduced risk of hyperkalemia in an animal model of nephropathy

    Directory of Open Access Journals (Sweden)

    Stephen eOrena

    2013-10-01

    Full Text Available The mineralocorticoid receptor (MR antagonists PF 03882845 and eplerenone were evaluated for renal protection against aldosterone mediated renal disease in uninephrectomized Sprague Dawley (SD rats maintained on a high salt diet and receiving aldosterone by osmotic mini pump for 27 days. Serum K+ and the urinary albumin to creatinine ratio (UACR were assessed following 14 and 27 days of treatment. Aldosterone induced renal fibrosis as evidenced by increases in UACR, collagen IV staining in kidney cortex, and expression of pro fibrotic genes relative to sham operated controls not receiving aldosterone. While both PF 03882845 and eplerenone elevated serum K+ levels with similar potencies, PF 03882845 was more potent than eplerenone in suppressing the rise in UACR. PF 03882845 prevented the increase in collagen IV staining at 5, 15 and 50 mg/kg BID while eplerenone was effective only at the highest dose tested (450 mg/kg BID. All doses of PF 03882845 suppressed aldosterone induced increases in collagen IV, transforming growth factor 1 (Tgf 1, interleukin 6 (Il-6, intermolecular adhesion molecule 1 (Icam-1 and osteopontin gene expression in kidney while eplerenone was only effective at the highest dose. The therapeutic index (TI, calculated as the ratio of the EC50 for increasing serum K+ to the EC50 for UACR lowering, was 83.8 for PF 03882845 and 1.47 for eplerenone. Thus the TI of PF 03882845 against hyperkalemia was 57 fold superior to that of eplerenone indicating that PF 03882845 may present significantly less risk for hyperkalemia compared to eplerenone.

  4. Attenuation of ketamine-induced impairment in verbal learning and memory in healthy volunteers by the AMPA receptor potentiator PF-04958242.

    Science.gov (United States)

    Ranganathan, M; DeMartinis, N; Huguenel, B; Gaudreault, F; Bednar, M M; Shaffer, C L; Gupta, S; Cahill, J; Sherif, M A; Mancuso, J; Zumpano, L; D'Souza, D C

    2017-11-01

    There is a need to develop treatments for cognitive impairment associated with schizophrenia (CIAS). The significant role played by N-methyl-d-aspartate receptors (NMDARs) in both the pathophysiology of schizophrenia and in neuronal plasticity suggests that facilitation of NMDAR function might ameliorate CIAS. One strategy to correct NMDAR hypofunction is to stimulate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) as AMPAR and NMDAR functioning are coupled and interdependent. In rats and nonhuman primates (NHP), AMPAR potentiators reduce spatial working memory deficits caused by the nonselective NMDAR antagonist ketamine. The current study assessed whether the AMPAR potentiator PF-04958242 would attenuate ketamine-induced deficits in verbal learning and memory in humans. Healthy male subjects (n=29) participated in two randomized treatment periods of daily placebo or PF-04958242 for 5 days separated by a washout period. On day 5 of each treatment period, subjects underwent a ketamine infusion for 75 min during which the effects of PF-04958242/placebo were assessed on ketamine-induced: (1) impairments in verbal learning and recall measured by the Hopkins Verbal Learning Test; (2) impairments in working memory on a CogState battery; and (3) psychotomimetic effects measured by the Positive and Negative Syndrome Scale and Clinician-Administered Dissociative Symptoms Scale. PF-04958242 significantly reduced ketamine-induced impairments in immediate recall and the 2-Back and spatial working memory tasks (CogState Battery), without significantly attenuating ketamine-induced psychotomimetic effects. There were no pharmacokinetic interactions between PF-04958242 and ketamine. Furthermore, PF-04958242 was well tolerated. 'High-impact' AMPAR potentiators like PF-04958242 may have a role in the treatment of the cognitive symptoms, but not the positive or negative symptoms, associated with schizophrenia. The excellent concordance between the

  5. An Interspecies Signaling System Mediated by Fusaric Acid Has Parallel Effects on Antifungal Metabolite Production by Pseudomonas protegens Strain Pf-5 and Antibiosis of Fusarium spp.

    Science.gov (United States)

    Quecine, Maria Carolina; Kidarsa, Teresa A.; Goebel, Neal C.; Shaffer, Brenda T.; Henkels, Marcella D.; Zabriskie, T. Mark

    2015-01-01

    Pseudomonas protegens strain Pf-5 is a rhizosphere bacterium that suppresses soilborne plant diseases and produces at least seven different secondary metabolites with antifungal properties. We derived mutants of Pf-5 with single and multiple mutations in biosynthesis genes for seven antifungal metabolites: 2,4-diacetylphoroglucinol (DAPG), pyrrolnitrin, pyoluteorin, hydrogen cyanide, rhizoxin, orfamide A, and toxoflavin. These mutants were tested for inhibition of the pathogens Fusarium verticillioides and Fusarium oxysporum f. sp. pisi. Rhizoxin, pyrrolnitrin, and DAPG were found to be primarily responsible for fungal antagonism by Pf-5. Previously, other workers showed that the mycotoxin fusaric acid, which is produced by many Fusarium species, including F. verticillioides, inhibited the production of DAPG by Pseudomonas spp. In this study, amendment of culture media with fusaric acid decreased DAPG production, increased pyoluteorin production, and had no consistent influence on pyrrolnitrin or orfamide A production by Pf-5. Fusaric acid also altered the transcription of biosynthetic genes, indicating that the mycotoxin influenced antibiotic production by Pf-5 at the transcriptional level. Addition of fusaric acid to the culture medium reduced antibiosis of F. verticillioides by Pf-5 and derivative strains that produce DAPG but had no effect on antibiosis by Pf-5 derivatives that suppressed F. verticillioides due to pyrrolnitrin or rhizoxin production. Our results demonstrated the importance of three compounds, rhizoxin, pyrrolnitrin, and DAPG, in suppression of Fusarium spp. by Pf-5 and confirmed that an interspecies signaling system mediated by fusaric acid had parallel effects on antifungal metabolite production and antibiosis by the bacterial biological control organism. PMID:26655755

  6. An Interspecies Signaling System Mediated by Fusaric Acid Has Parallel Effects on Antifungal Metabolite Production by Pseudomonas protegens Strain Pf-5 and Antibiosis of Fusarium spp.

    Science.gov (United States)

    Quecine, Maria Carolina; Kidarsa, Teresa A; Goebel, Neal C; Shaffer, Brenda T; Henkels, Marcella D; Zabriskie, T Mark; Loper, Joyce E

    2015-12-11

    Pseudomonas protegens strain Pf-5 is a rhizosphere bacterium that suppresses soilborne plant diseases and produces at least seven different secondary metabolites with antifungal properties. We derived mutants of Pf-5 with single and multiple mutations in biosynthesis genes for seven antifungal metabolites: 2,4-diacetylphoroglucinol (DAPG), pyrrolnitrin, pyoluteorin, hydrogen cyanide, rhizoxin, orfamide A, and toxoflavin. These mutants were tested for inhibition of the pathogens Fusarium verticillioides and Fusarium oxysporum f. sp. pisi. Rhizoxin, pyrrolnitrin, and DAPG were found to be primarily responsible for fungal antagonism by Pf-5. Previously, other workers showed that the mycotoxin fusaric acid, which is produced by many Fusarium species, including F. verticillioides, inhibited the production of DAPG by Pseudomonas spp. In this study, amendment of culture media with fusaric acid decreased DAPG production, increased pyoluteorin production, and had no consistent influence on pyrrolnitrin or orfamide A production by Pf-5. Fusaric acid also altered the transcription of biosynthetic genes, indicating that the mycotoxin influenced antibiotic production by Pf-5 at the transcriptional level. Addition of fusaric acid to the culture medium reduced antibiosis of F. verticillioides by Pf-5 and derivative strains that produce DAPG but had no effect on antibiosis by Pf-5 derivatives that suppressed F. verticillioides due to pyrrolnitrin or rhizoxin production. Our results demonstrated the importance of three compounds, rhizoxin, pyrrolnitrin, and DAPG, in suppression of Fusarium spp. by Pf-5 and confirmed that an interspecies signaling system mediated by fusaric acid had parallel effects on antifungal metabolite production and antibiosis by the bacterial biological control organism. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  7. PF1163A and B, new antifungal antibiotics produced by Penicillium sp. I. Taxonomy of producing strain, fermentation, isolation and biological activities.

    Science.gov (United States)

    Nose, H; Seki, A; Yaguchi, T; Hosoya, A; Sasaki, T; Hoshiko, S; Shomura, T

    2000-01-01

    Two novel antifungal antibiotics, PF1163A and B, were isolated from the fermentation broth of Penicillium sp. They were purified from the solid cultures of rice media using ethyl acetate extraction, silica gel and Sephadex LH-20 column chromatographies. PF1163A and B showed potent growth inhibitory activity against pathogenic fungal strain Candida albicans but did not show cytotoxic activity against mammalian cells. These compounds inhibited the ergosterol biosynthesis in Candida albicans.

  8. A specific PfEMP1 is expressed in P. falciparum sporozoites and plays a role in hepatocyte infection

    DEFF Research Database (Denmark)

    Zanghì, Gigliola; Vembar, Shruthi S; Baumgarten, Sebastian

    2018-01-01

    Heterochromatin plays a central role in the process of immune evasion, pathogenesis, and transmission of the malaria parasite Plasmodium falciparum during blood stage infection. Here, we use ChIP sequencing to demonstrate that sporozoites from mosquito salivary glands expand heterochromatin......_SpzPfEMP1. Overall, we show that the epigenetic signature of var genes is reset in mosquito stages. Moreover, the identification of a strain-specific sporozoite PfEMP1 is highly relevant for vaccine design based on sporozoites....

  9. SAM domain-dependent activity of PfTKL3, an essential tyrosine kinase-like kinase of the human malaria parasite Plasmodium falciparum.

    Science.gov (United States)

    Abdi, Abdirahman; Eschenlauer, Sylvain; Reininger, Luc; Doerig, Christian

    2010-10-01

    Over the last decade, several protein kinases inhibitors have reached the market for cancer chemotherapy. The kinomes of pathogens represent potentially attractive targets in infectious diseases. The functions of the majority of protein kinases of Plasmodium falciparum, the parasitic protist responsible for the most virulent form of human malaria, remain unknown. Here we present a thorough characterisation of PfTKL3 (PF13_0258), an enzyme that belongs to the tyrosine kinase-like kinase (TKL) group. We demonstrate by reverse genetics that PfTKL3 is essential for asexual parasite proliferation in human erythrocytes. PfTKL3 is expressed in both asexual and gametocytes stages, and in the latter the protein co-localises with cytoskeleton microtubules. Recombinant PfTKL3 displays in vitro autophosphorylation activity and is able to phosphorylate exogenous substrates, and both activities are dramatically dependent on the presence of an N-terminal "sterile alpha-motif" domain. This study identifies PfTKL3 as a validated drug target amenable to high-throughput screening.

  10. Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials

    Science.gov (United States)

    2015-01-01

    Aminopyrazoles are a new class of antimalarial compounds identified in a cellular antiparasitic screen with potent activity against Plasmodium falciparum asexual and sexual stage parasites. To investigate their unknown mechanism of action and thus identify their target, we cultured parasites in the presence of a representative member of the aminopyrazole series, GNF-Pf4492, to select for resistance. Whole genome sequencing of three resistant lines showed that each had acquired independent mutations in a P-type cation-transporter ATPase, PfATP4 (PF3D7_1211900), a protein implicated as the novel Plasmodium spp. target of another, structurally unrelated, class of antimalarials called the spiroindolones and characterized as an important sodium transporter of the cell. Similarly to the spiroindolones, GNF-Pf4492 blocks parasite transmission to mosquitoes and disrupts intracellular sodium homeostasis. Our data demonstrate that PfATP4 plays a critical role in cellular processes, can be inhibited by two distinct antimalarial pharmacophores, and supports the recent observations that PfATP4 is a critical antimalarial target. PMID:25322084

  11. Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds.

    Directory of Open Access Journals (Sweden)

    Diana Ortiz

    Full Text Available Development of resistance against current antimalarial drugs necessitates the search for novel drugs that interact with different targets and have distinct mechanisms of action. Malaria parasites depend upon high levels of glucose uptake followed by inefficient metabolic utilization via the glycolytic pathway, and the Plasmodium falciparum hexose transporter PfHT, which mediates uptake of glucose, has thus been recognized as a promising drug target. This transporter is highly divergent from mammalian hexose transporters, and it appears to be a permease that is essential for parasite viability in intra-erythrocytic, mosquito, and liver stages of the parasite life cycle. An assay was developed that is appropriate for high throughput screening against PfHT based upon heterologous expression of PfHT in Leishmania mexicana parasites that are null mutants for their endogenous hexose transporters. Screening of two focused libraries of antimalarial compounds identified two such compounds that are high potency selective inhibitors of PfHT compared to human GLUT1. Additionally, 7 other compounds were identified that are lower potency and lower specificity PfHT inhibitors but might nonetheless serve as starting points for identification of analogs with more selective properties. These results further support the potential of PfHT as a novel drug target.

  12. A cross-species translational pharmacokinetic-pharmacodynamic evaluation of core body temperature reduction by the TRPM8 blocker PF-05105679.

    Science.gov (United States)

    Gosset, James R; Beaumont, Kevin; Matsuura, Tomomi; Winchester, Wendy; Attkins, Neil; Glatt, Sophie; Lightbown, Ian; Ulrich, Kristina; Roberts, Sonia; Harris, Jolie; Mesic, Emir; van Steeg, Tamara; Hijdra, Diana; van der Graaf, Piet H

    2017-11-15

    PF-05105679 is a moderately potent TRPM8 blocker which has been evaluated for the treatment of cold pain sensitivity. The TRPM8 channel is responsible for the sensation of cold environmental temperatures and has been implicated in regulation of core body temperature. Consequently, blockade of TRPM8 has been suggested to result in lowering of core body temperature. As part of the progression to human studies, the effect of PF-05105679 on core body temperature has been investigated in animals. Safety pharmacology studies showed that PF-05105679 reduced core body temperature in a manner that was inversely related to body weight of the species tested (greater exposure to PF-05105679 was required to lower temperature by 1°C in higher species). Based on an allometric (body weight) relationship, it was hypothesized that PF-05105679 would not lower core body temperature in humans at exposures that could exhibit pharmacological effects on cold pain sensation. On administration to humans, PF-05105679 was indeed effective at reversing the cold pain sensation associated with the cold pressor test in the absence of effects on core body temperature. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Transient phenomena in the final implosion stage at the PF-1000 facility

    International Nuclear Information System (INIS)

    Gribkov, V.A.; Banaszak, A.; Jakubowski, L.; Sadowski, M.J.; Szydlowski, A.; Bienkowska, B.; Borowiecki, M.; Ivanova-Stanik, I.; Karpinski, L.; Miklaszewski, R.A.; Paduch, M.; Scholz, M.; Tomaszewski, K.; Dubrovsky, A.V.

    2006-12-01

    This paper consists of two parts, which are essentially constituted as a single whole. Dense Plasma Focus device (DPF), which is known from the early 50's, is the oldest machine which has survived since the very beginning of thermonuclear researches. This is a high voltage high-current pulsed discharge, which is produced usually by a discharge of a capacitor bank in various gases. It consists of two coaxial electrodes with the central one (anode) spanned by a ring insulator. The device is known in two configurations of electrodes named by their creators - the Filippov type (in year 1954) and the Mather one (1961). The first configuration, elaborated in the Kurchatov Institute for Atomic Energy, Moscow, Russia, has a flat anode of disc shape lying directly on the upper edge of an insulator and a cathode ('liner') looks like a pan turned up-side down and covers the anode from the top. This is a relatively infrequent modification used at the present time in two or three centres. The second one was elaborated in the Los Alamos scientific laboratory, USA, and this has an anode in the shape of a tube with a flat lid on the top of it. Cathode is usually made in the form of a squirrel cage, i.e. containing a number of rods placed along the circumference around the anode tube. These devices on the low level of the energy stored in the bank are important due to their numerous applications. The upper level of the bank energy reached at present is interesting because of its perspectives as a unique neutron source for use in nuclear physics and radiation material sciences. The main processes taking place during a development of the discharge is described in this paper. Here we shall mention that the paper is devoted to investigations of physical processes taking place in the PF-1000 facility. This device was put into operation with full energy stored in the bank at the Institute of Plasma Physics and Laser Microfusion, Warsaw, Poland, about two years ago. The energy in the bank

  14. French scientists offered time to set up companies

    CERN Document Server

    Butler, D

    1999-01-01

    The French minister of national education, research and technology announced that French researchers working for public research institutes and universities are to be offered up to six years sabbatical leave to set up their own companies (11 para)

  15. FRENCH LANGUAGE: A BASIC G.S COURSE FOR NNAMDI ...

    African Journals Online (AJOL)

    JONATHAN

    2016-07-01

    Jul 1, 2016 ... Presently in Nnamdi Azikiwe University (NAU), apart from students majoring in French .... Oyo states that the inclusion of French language into the general studies ... securing a job in the labour market that is already saturated.

  16. Effect of benzylaminopurine on in vivo multiplication of French plantain

    African Journals Online (AJOL)

    SARAH

    2014-02-28

    Feb 28, 2014 ... of French plantain (Musa spp. AAB) cv. ... Figure 1: Plant and fruit appearance of French plantain cv. "Itoke Sege" .... Control of lethal browning of tissue culture plantlets of ... Research Workshop on Food Security,. Morogoro ...

  17. Capturing the effect of [PF3(C2F5)3]-vs. [PF6]-, flexible anion vs. rigid, and scaled charge vs. unit on the transport properties of [bmim]+-based ionic liquids: a comparative MD study.

    Science.gov (United States)

    Kowsari, Mohammad H; Ebrahimi, Soraya

    2018-05-16

    Comprehensive molecular dynamics simulations are performed to study the average single-particle dynamics and the transport properties of 1-butyl-3-methylimidazolium hexafluorophosphate, [bmim][PF6], and 1-butyl-3-methylimidazolium tris(pentafluoroethyl)trifluorophosphate, [bmim][FAP], ionic liquids (ILs) at 400 K. We applied one of the most widely used nonpolarizable all-atom force fields for ILs, both with the original unit (±1) charges on each ion and with the partial charges uniformly scaled to 80-85%, taking into account the average polarizability and tracing the experimentally compatible transport properties. In all simulations, [bmim]+ was considered to be flexible, while the effect of a flexible vs. rigid structure of the anions and the effect of two applied charge sets on the calculated properties were separately investigated in detail. The simulation results showed that replacing [PF6]- with [FAP]-, considering anion flexibility, and applying the charge-scaled model significantly enhanced the ionic self-diffusion, ionic conductivity, inverse viscosity, and hyper anion preference (HAP). Both of the calculated self-diffusion coefficients from the long-time linear slope of the mean-square displacement (MSD) and from the integration of the velocity autocorrelation function (VACF) for the centers of mass of the ions were used for evaluation of the ionic transference number, HAP, ideal Nernst-Einstein ionic conductivity (σNE), and the Stokes-Einstein viscosity. In addition, for quantification of the degree of complicated ionic association (known as the Nernst-Einstein deviation parameter, Δ) and ionicity phenomena in the two studied ILs, the ionic conductivity was determined more rigorously by the Green-Kubo integral of the electric-current autocorrelation function (ECACF), and then the σGK/σNE ratio was evaluated. It was found that the correlated motion of the (cationanion) neighbors in [bmim][FAP] is smaller than in [bmim][PF6]. The relaxation times of

  18. Films for French: A Teacher's Guide.

    Science.gov (United States)

    Savignon, Sandra J., Ed.

    More than 100 films, selected for use in college-level French programs, are evaluated in this teaching guide. Films are listed alphabetically under the following categories: (1) "Beaux-Arts," (2) "La France Contemporaine," (3) "La France et le Nouveau Monde," (4) "Histoire," and (5) "Langue." The index gives an alphabetical list of all the films…

  19. Come back on the french gas winter

    International Nuclear Information System (INIS)

    2006-01-01

    The document analyzes the french gas market behavior during the winter 2005/2006: the gas consumption, the imports decrease was offset by the the liquefied natural gas supply increase at Fos, the stocks levels and the transparency of the information. (A.L.B.)

  20. French nuclear power plants. Results and outlooks

    International Nuclear Information System (INIS)

    Serres, S.; Carbonnier, D.

    1999-01-01

    Operating results were good in 1997 for French nuclear power plants: safety levels were perfectly satisfactory; operating expenses continued to decrease (by 2% per annum from 1992 to 1997); there were spectacular results in radiation protection; and they had one of the world's highest availability rates (nearly 83%). (orig.) [de