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Sample records for on-line repositioning based

  1. Drug repositioning for diabetes based on 'omics' data mining.

    Directory of Open Access Journals (Sweden)

    Ming Zhang

    Full Text Available Drug repositioning has shorter developmental time, lower cost and less safety risk than traditional drug development process. The current study aims to repurpose marketed drugs and clinical candidates for new indications in diabetes treatment by mining clinical 'omics' data. We analyzed data from genome wide association studies (GWAS, proteomics and metabolomics studies and revealed a total of 992 proteins as potential anti-diabetic targets in human. Information on the drugs that target these 992 proteins was retrieved from the Therapeutic Target Database (TTD and 108 of these proteins are drug targets with drug projects information. Research and preclinical drug targets were excluded and 35 of the 108 proteins were selected as druggable proteins. Among them, five proteins were known targets for treating diabetes. Based on the pathogenesis knowledge gathered from the OMIM and PubMed databases, 12 protein targets of 58 drugs were found to have a new indication for treating diabetes. CMap (connectivity map was used to compare the gene expression patterns of cells treated by these 58 drugs and that of cells treated by known anti-diabetic drugs or diabetes risk causing compounds. As a result, 9 drugs were found to have the potential to treat diabetes. Among the 9 drugs, 4 drugs (diflunisal, nabumetone, niflumic acid and valdecoxib targeting COX2 (prostaglandin G/H synthase 2 were repurposed for treating type 1 diabetes, and 2 drugs (phenoxybenzamine and idazoxan targeting ADRA2A (Alpha-2A adrenergic receptor had a new indication for treating type 2 diabetes. These findings indicated that 'omics' data mining based drug repositioning is a potentially powerful tool to discover novel anti-diabetic indications from marketed drugs and clinical candidates. Furthermore, the results of our study could be related to other disorders, such as Alzheimer's disease.

  2. Drug Repositioning for Diabetes Based on 'Omics' Data Mining

    Science.gov (United States)

    Zhang, Ming; Luo, Heng; Xi, Zhengrui; Rogaeva, Ekaterina

    2015-01-01

    Drug repositioning has shorter developmental time, lower cost and less safety risk than traditional drug development process. The current study aims to repurpose marketed drugs and clinical candidates for new indications in diabetes treatment by mining clinical ‘omics’ data. We analyzed data from genome wide association studies (GWAS), proteomics and metabolomics studies and revealed a total of 992 proteins as potential anti-diabetic targets in human. Information on the drugs that target these 992 proteins was retrieved from the Therapeutic Target Database (TTD) and 108 of these proteins are drug targets with drug projects information. Research and preclinical drug targets were excluded and 35 of the 108 proteins were selected as druggable proteins. Among them, five proteins were known targets for treating diabetes. Based on the pathogenesis knowledge gathered from the OMIM and PubMed databases, 12 protein targets of 58 drugs were found to have a new indication for treating diabetes. CMap (connectivity map) was used to compare the gene expression patterns of cells treated by these 58 drugs and that of cells treated by known anti-diabetic drugs or diabetes risk causing compounds. As a result, 9 drugs were found to have the potential to treat diabetes. Among the 9 drugs, 4 drugs (diflunisal, nabumetone, niflumic acid and valdecoxib) targeting COX2 (prostaglandin G/H synthase 2) were repurposed for treating type 1 diabetes, and 2 drugs (phenoxybenzamine and idazoxan) targeting ADRA2A (Alpha-2A adrenergic receptor) had a new indication for treating type 2 diabetes. These findings indicated that ‘omics’ data mining based drug repositioning is a potentially powerful tool to discover novel anti-diabetic indications from marketed drugs and clinical candidates. Furthermore, the results of our study could be related to other disorders, such as Alzheimer’s disease. PMID:25946000

  3. [Discovering L-type calcium channels inhibitors of antihypertensive drugs based on drug repositioning].

    Science.gov (United States)

    Liang, Ying-xi; He, Yu-su; Jiang, Lu-di; Yue, Qiao-xin; Cui, Shuai; Bin, Li; Ye, Xiao-tong; Zhang, Xiao-hua; Zhang, Yang-ling

    2015-09-01

    This study was amid to construct the pharmacophore model of L-type calcium channel antagonist in the application of screening Drugbank and TCMD. This paper repositions the approved drugs resulting from virtual screening and discusses the relocation-based drug discovery methods, screening antihypertensive drugs with L-type calcium channel function from TCMD. Qualitative hypotheses wre generated by HipHop separately on the basis of 12 compounds with antagonistic action on L-type calcium channel expressed in rabbit cardiac muscle. Datebase searching method was used to evaluate the generated hypotheses. The optimum hypothesis was used to search Drugbank and TCMD. This paper repositions the approved drugs and evaluates the antihypertensive effect of the chemical constituent of traditional Chinese medicine resulting from virtual screening by the matching score and literature. The results showed that optimum qualitative hypothesis is with six features, which were two hydrogen-bond acceptors, four hydrophobic groups, and the CAI value of 2.78. Screening Drugbank achieves 93 approved drugs. Screening TCMD achieves 285 chemical constituents of traditional Chinese medicine. It was concluded that the hypothesis is reliable and can be used to screen datebase. The approved drugs resulting from virtual screening, such as pravastatin, are potentially L-type calcium channels inhibitors. The chemical constituents of traditional Chinese medicine, such as Arctigenin III and Arctigenin are potentially antihypertensive drugs. It indicates that Drug Repositioning based on hypothesis is possible.

  4. Mining drug-disease relationships as a complement to medical genetics-based drug repositioning: Where a recommendation system meets genome-wide association studies.

    Science.gov (United States)

    Wang, H; Gu, Q; Wei, J; Cao, Z; Liu, Q

    2015-05-01

    A novel recommendation-based drug repositioning strategy is presented to simultaneously determine novel drug indications and side effects in one integrated framework. This strategy provides a complementary method to medical genetics-based drug repositioning, which reduces the occurrence of false positives in medical genetics-based drug repositioning, resulting in a ranked list of new candidate indications and/or side effects with different confidence levels. Several new drug indications and side effects are reported with high prediction confidences.

  5. Individualized network-based drug repositioning infrastructure for precision oncology in the panomics era.

    Science.gov (United States)

    Cheng, Feixiong; Hong, Huixiao; Yang, Shengyong; Wei, Yuquan

    2016-06-12

    Advances in next-generation sequencing technologies have generated the data supporting a large volume of somatic alterations in several national and international cancer genome projects, such as The Cancer Genome Atlas and the International Cancer Genome Consortium. These cancer genomics data have facilitated the revolution of a novel oncology drug discovery paradigm from candidate target or gene studies toward targeting clinically relevant driver mutations or molecular features for precision cancer therapy. This focuses on identifying the most appropriately targeted therapy to an individual patient harboring a particularly genetic profile or molecular feature. However, traditional experimental approaches that are used to develop new chemical entities for targeting the clinically relevant driver mutations are costly and high-risk. Drug repositioning, also known as drug repurposing, re-tasking or re-profiling, has been demonstrated as a promising strategy for drug discovery and development. Recently, computational techniques and methods have been proposed for oncology drug repositioning and identifying pharmacogenomics biomarkers, but overall progress remains to be seen. In this review, we focus on introducing new developments and advances of the individualized network-based drug repositioning approaches by targeting the clinically relevant driver events or molecular features derived from cancer panomics data for the development of precision oncology drug therapies (e.g. one-person trials) to fully realize the promise of precision medicine. We discuss several potential challenges (e.g. tumor heterogeneity and cancer subclones) for precision oncology. Finally, we highlight several new directions for the precision oncology drug discovery via biotherapies (e.g. gene therapy and immunotherapy) that target the 'undruggable' cancer genome in the functional genomics era.

  6. Computational drug repositioning based on side-effects mined from social media

    Directory of Open Access Journals (Sweden)

    Timothy Nugent

    2016-02-01

    Full Text Available Drug repositioning methods attempt to identify novel therapeutic indications for marketed drugs. Strategies include the use of side-effects to assign new disease indications, based on the premise that both therapeutic effects and side-effects are measurable physiological changes resulting from drug intervention. Drugs with similar side-effects might share a common mechanism of action linking side-effects with disease treatment, or may serve as a treatment by “rescuing” a disease phenotype on the basis of their side-effects; therefore it may be possible to infer new indications based on the similarity of side-effect profiles. While existing methods leverage side-effect data from clinical studies and drug labels, evidence suggests this information is often incomplete due to under-reporting. Here, we describe a novel computational method that uses side-effect data mined from social media to generate a sparse undirected graphical model using inverse covariance estimation with ℓ1-norm regularization. Results show that known indications are well recovered while current trial indications can also be identified, suggesting that sparse graphical models generated using side-effect data mined from social media may be useful for computational drug repositioning.

  7. Creativity Repositioned

    Science.gov (United States)

    Sheridan-Rabideau, Mark

    2010-01-01

    Creativity is the cultural capital of the twenty-first century. This article presents an argument for the arts to lead a new wave of education reform that repositions creativity as the centerpiece of an education that prepares a generation of change agents for doing good.

  8. On-Line Voltage Stability Assessment based on PMU Measurements

    DEFF Research Database (Denmark)

    Garcia-Valle, Rodrigo; P. Da Silva, Luiz C.; Nielsen, Arne Hejde

    2009-01-01

    through statistic analysis. During the off-line analysis, a memory of high-risk situations following a pre-defined voltage stability criterion is obtained. Thereafter, basic statistics analyses are applied resulting in the definition of voltage regions. During on-line operation, voltage magnitudes......This paper presents a method for on-line monitoring of risk voltage collapse based on synchronised phasor measurement. As there is no room for intensive computation and analysis in real-time, the method is based on the combination of off-line computation and on-line monitoring, which are correlated...... of critical buses obtained by phasor measurements are monitored in relation to the risk regions. Comprehensive studies demonstrate that the proposed method could assist operators to avoid voltage collapse events, by taking preventive or emergency actions....

  9. Prediction of drug-target interactions for drug repositioning only based on genomic expression similarity.

    Directory of Open Access Journals (Sweden)

    Kejian Wang

    Full Text Available Small drug molecules usually bind to multiple protein targets or even unintended off-targets. Such drug promiscuity has often led to unwanted or unexplained drug reactions, resulting in side effects or drug repositioning opportunities. So it is always an important issue in pharmacology to identify potential drug-target interactions (DTI. However, DTI discovery by experiment remains a challenging task, due to high expense of time and resources. Many computational methods are therefore developed to predict DTI with high throughput biological and clinical data. Here, we initiatively demonstrate that the on-target and off-target effects could be characterized by drug-induced in vitro genomic expression changes, e.g. the data in Connectivity Map (CMap. Thus, unknown ligands of a certain target can be found from the compounds showing high gene-expression similarity to the known ligands. Then to clarify the detailed practice of CMap based DTI prediction, we objectively evaluate how well each target is characterized by CMap. The results suggest that (1 some targets are better characterized than others, so the prediction models specific to these well characterized targets would be more accurate and reliable; (2 in some cases, a family of ligands for the same target tend to interact with common off-targets, which may help increase the efficiency of DTI discovery and explain the mechanisms of complicated drug actions. In the present study, CMap expression similarity is proposed as a novel indicator of drug-target interactions. The detailed strategies of improving data quality by decreasing the batch effect and building prediction models are also effectively established. We believe the success in CMap can be further translated into other public and commercial data of genomic expression, thus increasing research productivity towards valid drug repositioning and minimal side effects.

  10. A Fingerprint Minutiae Matching Method Based on Line Segment Vector

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Minutiae-based fingerprint matching is the most commonly used in an automatic fingerprint identification system. In this paper, we propose a minutia matching method based on line segment vector. This method uses all the detected minutiae (the ridge ending and the ridge bifurcation) in a fingerprint image to create a set of new vectors (line segment vector). Using these vectors, we can determine a truer reference point more efficiently. In addition, this new minutiae vector can also increase the accuracy of the minutiae matching. By experiment on the public domain collections of fingerprint images fvc2004 DB3 set A and DB4 set A, the result shows that our algorithm can obtain an improved verification performance.

  11. On-line Test for Train Communication Based System

    Institute of Scientific and Technical Information of China (English)

    Zeng Xiaoqing; Masayuki Matsumoto; Kinji Mori; XU Fucang

    2002-01-01

    This paper gives out a new train automatic control system, which is based on train communication, and proposes a high assurance method to construct the system from current system. In current automatic train control (ATC) system, the central logic device detects position of each train and calculates permissible speed of each blocking section. Therefore, the central logic device controls speed of all trains. On the contrary, in the new system proposed in this paper, there is no central logical device and, train can communicate each other. The train detects the position and calculates the permissible speed itself according to the received position information of the preceding train. In the traditional method of changing an old system to a new one, test must be done off-line.While the integration technique proposed in this paper achieves on-line properties, and high assurance can be satisfied.

  12. On-line alkali detector based on surface ionization

    Energy Technology Data Exchange (ETDEWEB)

    Olsson, J.G.; Loenn, B.; Jaeglid, B.; Engvall, K.; Pettersson, J.B.C. [Chalmers University of Technology, Goeteborg (Sweden). Dept. of Physical Chemistry GU

    1998-12-31

    This project adapts a new on-line alkali measurement technique to coal and biomass combustion and gasification. Alkali metal atoms are known to easily ionize in contact with hot metal surfaces, and the instrument is based on this principle called surface ionization (SI). The primary parts of the detector are a platinum filament and an ion collector. The platinum filament is supported between two electrodes and heated to the temperature for alkali vaporization in ionic form. The ion collector is situated close to the filament. The measured current is proportional to the arrival rate of alkali atoms onto the filament. Laboratory tests were performed on detector sensitivity, detection limit, and time response. Similar sensitivity to both sodium and potassium regardless of molecular form was found. The time response of the detector is determined to be approximately 1 ms enabling it to monitor fast concentration changes in flue gas. Particles with a size below 5 nm melt completely on the hot platinum surface and give similar signals. For larger particles, the ionization efficiency is not 100% and depends on the type of salt. This problem can be overcome with an alternative filament configuration. The detector function was tested in a laboratory high pressure furnace using different fuel samples, atmospheres, and pressures. Alkali release from coal in general is lower than for biomass samples, rate constants and activation energies for alkali release were determined. Measurements were carried out in a biomass pyrolysis apparatus and a gasification pilot plant. The detector function was not influenced by a high concentration of hydrocarbons in the gas phase, and the measurements confirmed detector function in a hostile environment. The detector performed well in laboratory tests, and is a strong candidate for further development into a standard on-line monitor of alkali species in hot flue gas. 10 refs., 16 figs.

  13. On-line Autonomous Learning Based on Leamerg Expectation

    Institute of Scientific and Technical Information of China (English)

    李利娜

    2008-01-01

    On-line autonomous learning of College English is one of the important reforms in colleges recently.This paper aims to explore the changes of teachers'role in the new on-line setting.The article first reviews the theoretical study of learner autonomy,then makes a practical investigation into the attitude and expectation learners have on teachers through a self-designed questionnaire,and explores that teachers should make an adjustment to their role orientation and changes their roles into motivators,evaluators and resources supphers in the new on-line setting.

  14. A Novel Low-Torque Ball Re-Positioning Scheme Based on a Sliding-Mode Ball Observer for an Automatic Balancer System

    Directory of Open Access Journals (Sweden)

    Paul C.-P. Chao

    2008-01-01

    Full Text Available A novel low-torque ball re-positioning scheme based on a sliding-mode ball observer is developed in this study with the aim to precisely reside the rolling ball inside an automatic balancer system (ABS to its desired position – 180 degree opposite to the inherent imbalance of the rotating system which the ABS is attached to. In this way, the ABS is capable of substantially reducing radial vibrations of the rotating system for a decent balancing. For preliminary feasibility, the case of a single ball is considered in this study. The first step is to establish the dynamic model of the system, which is followed by the analysis to ensure stability of the desired ball position. The second step is to forge a sliding-mode observer for estimating on-line position and velocity of the ball. With ball estimation capability, a low-torque speed regulator that essentially generates a series of speed drops to the neighborhood of suspension resonance is proposed to overcome practical ball rolling friction for residing the ball at the desired position. The design characteristic of low-torque required for the regulator is particularly suited to most of commercial spindle motors which can only output limited torques at high speeds. Finally, simulations and experiments are conducted for a benchmark problem of optical disc drives in order to verify the effectiveness of the proposed scheme of the sliding-mode observer and the low-torque speed regulator.

  15. Association of Skin Thickness With Alar Base Reduction in Patients Undergoing Lateral Crural Repositioning and Strut Grafting.

    Science.gov (United States)

    Ilhan, A Emre; Sozen, Tevfik; Caypinar Eser, Basak; Cengiz, Betul

    2017-07-27

    Knowing the operation plan is important for rhinoplasty surgeons to prevent unpredictable results. To investigate the frequency of alar base resection in patients with different skin thickness who underwent lateral crural repositioning and lateral crural strut graft and to evaluate the results in the context of the current literature. This retrospective case series study included 621 patients who underwent primary open septorhinoplasty by the same surgeon between January 1, 2012, and June 30, 2015. From the surgical notes, operation type (lateral crural repositioning [LCrep] with lateral crural strut grafting [LCSG] and with or without alar base resection) and skin type were recorded. Study participants' skin types were determined intraoperatively and divided into 3 groups: (1) thick skin (the tip definition was limited by skin thickness and subcutaneous tissue), (2) thin skin (the tip cartilage was visible and could be observed despite overlying soft tissue and skin), and (3) normal skin (the tip cartilage during the procedure had no effect on the tip definition). Of the 621 patients in the study, 95 (15.3%) were men and 526 (84.7%) were women. Lateral crural repositioning with LCSG was performed in 319 surgical procedures (51.4%), and alar base reduction was performed in 329 (53.0%). The rate of alar base resection differed significantly on the basis of whether LCrep with LCSG was performed (odds ratio [OR], 1.82; 95% CI, 1.32-2.50; P alar base resection associated with LCrep with LCSG (OR, 2.034; 95% CI, 0.912-4.539; P = .08). In patients with thick skin, a significant difference in the frequency of alar base resection was associated with the application of LCrep with LCSG (OR, 1.995; 95% CI, 1.228-3.241; P = .005). In patients with normal skin, LCrep with LCSG had no significant association with the frequency of alar base resection (OR, 1.557; 95% CI, 0.930-2.607; P = .09). The necessity of alar base reduction after LCrep with LCSG is greater in

  16. Significance and suppression of redundant IL17 responses in acute allograft rejection by bioinformatics based drug repositioning of fenofibrate.

    Directory of Open Access Journals (Sweden)

    Silke Roedder

    Full Text Available Despite advanced immunosuppression, redundancy in the molecular diversity of acute rejection (AR often results in incomplete resolution of the injury response. We present a bioinformatics based approach for identification of these redundant molecular pathways in AR and a drug repositioning approach to suppress these using FDA approved drugs currently available for non-transplant indications. Two independent microarray data-sets from human renal allograft biopsies (n = 101 from patients on majorly Th1/IFN-y immune response targeted immunosuppression, with and without AR, were profiled. Using gene-set analysis across 3305 biological pathways, significant enrichment was found for the IL17 pathway in AR in both data-sets. Recent evidence suggests IL17 pathway as an important escape mechanism when Th1/IFN-y mediated responses are suppressed. As current immunosuppressions do not specifically target the IL17 axis, 7200 molecular compounds were interrogated for FDA approved drugs with specific inhibition of this axis. A combined IL17/IFN-y suppressive role was predicted for the antilipidemic drug Fenofibrate. To assess the immunregulatory action of Fenofibrate, we conducted in-vitro treatment of anti-CD3/CD28 stimulated human peripheral blood cells (PBMC, and, as predicted, Fenofibrate reduced IL17 and IFN-γ gene expression in stimulated PMBC. In-vivo Fenofibrate treatment of an experimental rodent model of cardiac AR reduced infiltration of total leukocytes, reduced expression of IL17/IFN-y and their pathway related genes in allografts and recipients' spleens, and extended graft survival by 21 days (p<0.007. In conclusion, this study provides important proof of concept that meta-analyses of genomic data and drug databases can provide new insights into the redundancy of the rejection response and presents an economic methodology to reposition FDA approved drugs in organ transplantation.

  17. Canalith Repositioning Procedure

    Science.gov (United States)

    ... repositioning procedure can help relieve benign paroxysmal positional vertigo (BPPV), a condition in which you have brief, ... dizziness that occur when you move your head. Vertigo usually comes from a problem with the part ...

  18. On-line and Model-based Approaches to the Visual Control of Action

    OpenAIRE

    Zhao, Huaiyong; Warren, William H.

    2014-01-01

    Two general approaches to the visual control of action have emerged in last few decades, known as the on-line and model-based approaches. The key difference between them is whether action is controlled by current visual information or on the basis of an internal world model. In this paper, we evaluate three hypotheses: strong on-line control, strong model-based control, and a hybrid solution that combines on-line control with weak off-line strategies. We review experimental research on the co...

  19. In vitro screening for drug repositioning.

    Science.gov (United States)

    Wilkinson, Graeme F; Pritchard, Kevin

    2015-02-01

    Drug repositioning or repurposing has received much coverage in the scientific literature in recent years and has been responsible for the generation of both new intellectual property and investigational new drug submissions. The literature indicates a significant trend toward the use of computational- or informatics-based methods for generating initial repositioning hypotheses, followed by focused assessment of biological activity in phenotypic assays. Another viable method for drug repositioning is in vitro screening of known drugs or drug-like molecules, initially in disease-relevant phenotypic assays, to identify and validate candidates for repositioning. This approach can use large compound libraries or can focus on subsets of known drugs or drug-like molecules. In this short review, we focus on ways to generate and validate repositioning candidates in disease-related in vitro and phenotypic assays, and we discuss specific examples of this approach as applied to a variety of disease areas. We propose that in vitro screens offer several advantages over biochemical or in vivo methods as a starting point for drug repositioning.

  20. Liner Shipping Fleet Repositioning

    DEFF Research Database (Denmark)

    Tierney, Kevin; Jensen, Rune Møller

    2011-01-01

    , can be accurately modeled. Numerous liner shipping fleet repositioning problems are solved each year by the world’s shipping firms without the assistance of any decision support, even though humans can require between two to three days to find a reasonable solution. Finding optimal repositionings...... to complex handling and timing restrictions. The objective of the problem is cost minimization, which translates nearly directly into the minimization of CO2 emissions and pollution. Additionally, it is important that all cost elements, including the ones that are only loosely coupled with activity choices...

  1. DBSR: Dynamic base station Repositioning using Genetic algorithm in wireless sensor network

    CERN Document Server

    Mollanejad, Amir; Zeynali, Mohammad

    2010-01-01

    Wireless sensor networks (WSNs) are commonly used in various ubiquitous and pervasive applications. Due to limited power resources, the optimal dynamic base station (BS) replacement could be Prolong the sensor network lifetime. In this paper we'll present a dynamic optimum method for base station replacement so that can save energy in sensors and increases network lifetime. Because positioning problem is a NPhard problem [1], therefore we'll use genetic algorithm to solve positioning problem. We've considered energy and distance parameters for finding BS optimized position. In our represented algorithm base station position is fixed just during each round and its positioning is done at the start of next round then it'll be placed in optimized position. Evaluating our proposed algorithm, we'll execute DBSR algorithm on LEACH & HEED Protocols.

  2. On-line interprofessional learning: introducing constructivism through enquiry-based learning and peer review.

    Science.gov (United States)

    Hughes, Matthew; Ventura, Susie; Dando, Mark

    2004-08-01

    Interest in on-line methods of learning has accelerated in recent years. There has also been an interest in developing student-centred approaches to learning and interprofessional education. This paper illustrates the issues in designing a large (more than 700 students), on-line, inter-professional module for third year, undergraduate students drawn from nine professional healthcare courses and from four campus sites. It uses an enquiry-based learning approach. The learning theories of Piaget, Vygotsky and Schön are integrated with the on-line frameworks of Salmon and Collis et al., together with conclusions drawn from the literature and our own experiences, to produce a design that encourages students to learn through participation, re-iteration, peer-review and reflection. Consideration is given to improving student motivation and attitudes towards change, both in the design and the delivery of the module.

  3. Competence based learning for an on-line course on flood modelling for management

    NARCIS (Netherlands)

    Popescu, Ioanna; Jonoski, Andreja; Keuls, Carel

    2009-01-01

    Popescu, I., Jonoski, A., & Keuls, C. (2009). Competence based learning for an on-line course on flood modelling for management. Proceedings of the 33rd International Association of Hydraulic Engineering & Research (IAHR Congress). August, 9-14, 2009, Vancouver, Canada: TENCompetence.

  4. On-line competence based learning in hydroinformatics, at UNESCO-IHE

    NARCIS (Netherlands)

    Popescu, Ioanna; Jonoski, Andreja; Bhattacharya, Biswa; Keuls, Carel

    2009-01-01

    Popescu, I., Jonoski, A., Bhattacharya, B., & Keuls, C. (2009). On-line competence based learning in hydroinformatics, at UNESCO-IHE. Proceedings of the 8th International Conference on Hydroinformatics-HIC 2009. January, 12-16, 2009, Conceptión, Chile: TENCompetence.

  5. Determination of Peroxide-Based Explosives Using Liquid Chromatography with On-Line Infrared Detection

    NARCIS (Netherlands)

    Schulte-Ladbeck, Rasmus; Edelmann, Andrea; Quintas, Guillermo; Lendl, Bernhard; Karst, U.

    2006-01-01

    A nondestructive analytical method for peroxide-based explosives determination in solid samples is described. Reversed-phase high-performance liquid chromatography in combination with on-line Fourier transform infrared (FT-IR) detection is used for the analysis of triacetonetriperoxide (TATP) and

  6. Determination of Peroxide-Based Explosives Using Liquid Chromatography with On-Line Infrared Detection

    NARCIS (Netherlands)

    Schulte-Ladbeck, Rasmus; Edelmann, Andrea; Quintas, Guillermo; Lendl, Bernhard; Karst, Uwe

    2006-01-01

    A nondestructive analytical method for peroxide-based explosives determination in solid samples is described. Reversed-phase high-performance liquid chromatography in combination with on-line Fourier transform infrared (FT-IR) detection is used for the analysis of triacetonetriperoxide (TATP) and he

  7. Problem-based learning in an on-line biotechnology course

    Science.gov (United States)

    Cheaney, James Daniel

    Problem-based learning (PBL) is a pedagogical tool that uses a "real world" problem or situation as a context for learning. PBL encourages student development of critical thinking skills, a high professional competency, problem-solving ability, knowledge acquisition, the ability to work productively as a team member and make decisions in unfamiliar situations, and the acquisition of skills that support self-directed life-long learning, metacognition, and adaptation to change. However, little research has focused on the use of PBL in on-line "virtual" classes. We conducted two studies exploring the use of PBL in an on-line biotechnology course. In the first study, ethical, legal, social, and human issues were used as a motivation for learning about DNA testing technologies, applications, and bioethical issues. In the second study, we combined PBL pedagogy with a rich multimedia environment of streaming video interviews, physical artifacts, and extensive links to articles and databases to create a multidimensional immersive PBL environment called "Robert's World". In "Robert's World", a man is determining whether to undergo a pre-symptomatic DNA test for an untreatable, incurable, fatal genetic disease for which he has a family history. In both studies, design and implementation issues of the on-line PBL environment are discussed, as are differences between on-line PBL and face-to-face PBL. Both studies provide evidence to suggest that PBL stimulates higher-order learning in students. However, in both studies, student performance on an exam testing acquisition of lower-order factual learning was lower for PBL students than for students who learned the same material through a traditional lecture-based approach. Possible reasons for this lower level of performance are explored. Student feedback expressed engagement with the issues and material covered, with reservations about some aspects of the PBL format, such as the lack of flexibility provided in cooperative

  8. A New Algorithm for On- Line Handwriting Signature Verification Based on Evolutionary Computation

    Institute of Scientific and Technical Information of China (English)

    ZHENG Jianbin; ZHU Guangxi

    2006-01-01

    The paper proposes an on-line signature verification algorithm, through which test sample and template signatures can be optimizedly matched, based on evolutionary computation (EC). Firstly, the similarity of signature curve segment is defined, and shift and scale transforms are also introduced due to the randoness of on-line signature. Secondly,this paper puts forward signature verification matching algorithm after establishment of the mathematical model. Thirdly, the concrete realization of the algorithm based on EC is discussed as well. In addition, the influence of shift and scale on the matching result is fully considered in the algorithm.Finally, a computation example is given, and the matching results between the test sample curve and the template signature curve are analyzed in detail. The preliminary experiments reveal that the type of signature verification problem can be solved by EC.

  9. On-line Batch Process Monitoring and Diagnosing Based on Fisher Discriminant Analysis

    Institute of Scientific and Technical Information of China (English)

    ZHAO Xu; SHAO Hui-he

    2006-01-01

    A new on-line batch process monitoring and diagnosing approach based on Fisher discriminant analysis (FDA) was proposed. This method does not need to predict the future observations of variables, so it is more sensitive to fault detection and stronger implement for monitoring. In order to improve the monitoring performance,the variables trajectories of batch process are separated into several blocks. The key to the proposed approach for on-line monitoring is to calculate the distance of block data that project to low-dimension Fisher space between new batch and reference batch. Comparing the distance with the predefine threshold, it can be considered whether the batch process is normal or abnormal. Fault diagnosis is performed based on the weights in fault direction calculated by FDA. The proposed method was applied to the simulation model of fed-batch penicillin fermentation and the results were compared with those obtained using MPCA. The simulation results clearly show that the on-line monitoring method based on FDA is more efficient than the MPCA.

  10. Research of on-line monitoring equipment for power capacitor based on wireless sensor network

    Science.gov (United States)

    Yu, Hao; Qian, Zheng; Yao, Junda; Xia, Jiuyun

    2016-01-01

    As the main electrical component for the reactive power compensation, the power capacitors are widely applied in many fields. And since the insulation condition of power capacitor could be identified accurately by using the on-line monitoring system, it attracts more and more attentions in recent years. In this paper, a novel on-line monitoring equipment for power capacitor based on wireless sensor network is presented. The operation data which includes the current and voltage of every capacitor is collected at first, and then the FFT is utilized to calculate the amplitude and phase of every signal, thus the insulation condition and the fault symptom could all be diagnosed accurately by analyzing the FFT results. In order to realize the effective isolation and the reliable communication between the sensing part and the merging unit, the wireless sensor network is adopted. The high reliability and transmission rate could be realized by using 2.4GHz UHF and 5GHz ISM radio bands. Thus the on-line monitoring system could be manufactured, and the lab test is carried at last. The testing results illustrate that this system could satisfy the requirement of on-site real-time measurement.

  11. On-line welding quality inspection system for steel pipe based on machine vision

    Science.gov (United States)

    Yang, Yang

    2017-05-01

    In recent years, high frequency welding has been widely used in production because of its advantages of simplicity, reliability and high quality. In the production process, how to effectively control the weld penetration welding, ensure full penetration, weld uniform, so as to ensure the welding quality is to solve the problem of the present stage, it is an important research field in the field of welding technology. In this paper, based on the study of some methods of welding inspection, a set of on-line welding quality inspection system based on machine vision is designed.

  12. Developing an EEG based On-line Closed-loop Lapse Detection and Mitigation System

    Directory of Open Access Journals (Sweden)

    Yu-Te eWang

    2014-10-01

    Full Text Available In America, sixty percent of adults reported that they have driven a motor vehicle while feeling drowsy, and at least 15-20% of fatal car accidents are fatigue-related. This study translates previous laboratory-oriented neurophysiological research to design, develop, and test an On-line Closed-loop Lapse Detection and Mitigation (OCLDM System featuring a mobile wireless dry-sensor EEG headgear and a cell-phone based real-time EEG processing platform. Eleven subjects participated in an event-related lane-keeping task, in which they were instructed to manipulate a randomly deviated, fixed-speed cruising car on a 4-lane highway. This was simulated in a 1st person view with an 8-screen and 8-projector immersive virtual-realty environment. When the subjects experienced lapses or failed to respond to events during the experiment, auditory feedback was delivered to rectify the performance decrements. However, the arousing auditory signals were not always effective. The EEG spectra exhibited statistically significant differences between effective and ineffective arousing signals, suggesting that EEG spectra could be used as a countermeasure of the efficacy of arousing signals. In this on-line pilot study, the proposed OCLDM System was able to continuously detect EEG signatures of fatigue, deliver arousing feedback to subjects suffering momentary cognitive lapses, and assess the efficacy of the feedback in near real-time to rectify cognitive lapses. The on-line testing results of the OCLDM System validated the efficacy of the arousing signals in improving subjects' response times to the subsequent lane-departure events. This study may lead to a practical on-line lapse detection and mitigation system in real-world environments.

  13. Repositioning for pressure ulcer prevention in adults.

    Science.gov (United States)

    Gillespie, Brigid M; Chaboyer, Wendy P; McInnes, Elizabeth; Kent, Bridie; Whitty, Jennifer A; Thalib, Lukman

    2014-04-03

    small difference in frequency of overnight repositioning in the 90º tilt groups between the trials). The third RCT compared alternative repositioning frequencies.All three studies reported the proportion of patients developing PU of any grade, stage or category. None of the trials reported on pain, or quality of life, and only one reported on cost. All three trials were at high risk of bias.The two trials of 30º tilt vs. 90º were pooled using a random effects model (I² = 69%) (252 participants). The risk ratio for developing a PU in the 30º tilt and the standard 90º position was very imprecise (pooled RR 0.62, 95% CI 0.10 to 3.97, P=0.62, very low quality evidence). This comparison is underpowered and at risk of a Type 2 error (only 21 events).In the third study, a cluster randomised trial, participants were randomised between 2-hourly and 3-hourly repositioning on standard hospital mattresses and 4 hourly and 6 hourly repositioning on viscoelastic foam mattresses. This study was also underpowered and at high risk of bias. The risk ratio for pressure ulcers (any category) with 2-hourly repositioning compared with 3-hourly repositioning on a standard mattress was imprecise (RR 0.90, 95% CI 0.69 to 1.16, very low quality evidence). The risk ratio for pressure ulcers (any category) was compatible with a large reduction and no difference between 4-hourly repositioning and 6-hourly repositioning on viscoelastic foam (RR 0.73, 95% CI 0.53 to 1.02, very low quality evidence).A cost-effectiveness analysis based on data derived from one of the included parallel RCTs compared 3-hourly repositioning using the 30º tilt overnight with standard care consisting of 6-hourly repositioning using the 90º lateral rotation overnight. In this evaluation the only included cost was nursing time. The intervention was reported to be cost saving compared with standard care (nurse time cost per patient €206.6 vs €253.1, incremental difference €-46.5; 95%CI: €-1.25 to €-74

  14. Integrating Multiple On-line Knowledge Bases for Disease-Lab Test Relation Extraction

    Science.gov (United States)

    Zhang, Yaoyun; Soysal, Ergin; Moon, Sungrim; Wang, Jingqi; Tao, Cui; Xu, Hua

    2015-01-01

    A computable knowledge base containing relations between diseases and lab tests would be a great resource for many biomedical informatics applications. This paper describes our initial step towards establishing a comprehensive knowledge base of disease and lab tests relations utilizing three public on-line resources. LabTestsOnline, MedlinePlus and Wikipedia are integrated to create a freely available, computable disease-lab test knowledgebase. Disease and lab test concepts are identified using MetaMap and relations between diseases and lab tests are determined based on source-specific rules. Experimental results demonstrate a high precision for relation extraction, with Wikipedia achieving the highest precision of 87%. Combining the three sources reached a recall of 51.40%, when compared with a subset of disease-lab test relations extracted from a reference book. Moreover, we found additional disease-lab test relations from on-line resources, indicating they are complementary to existing reference books for building a comprehensive disease and lab test relation knowledge base. PMID:26306271

  15. Intelligent control using multiple models based on on-line learning

    Institute of Scientific and Technical Information of China (English)

    Junyong ZHAI; Shumin FEI; Feipeng DA

    2006-01-01

    In this paper we deal with the problem of plants with large parameter variations under different operating modes. A novel intelligent control algorithm based on multiple models is proposed to improve the dynamical response performance. At the same time adaptive model bank is applied to establish models without prior system information.Multiple models and corresponding controllers are automatically established on-line by a conventionally adaptive model and a re-initialized one. A best controller is chosen by the performance function at every instant. The closed-loop system's stability and asymptotical convergence of tracking error can be guaranteed. Simulation results have confirmed the validity of the proposed method.

  16. An on-line remote supervisory system for microparticles based on image analysis

    Science.gov (United States)

    Liu, Wei-Hua; Jiang, Ming-Shun; Sui, Qing-Mei

    2011-11-01

    A new on-line remote particle analysis system based on image processing has been developed to measure microparticles. The system is composed of particle collector sensor (PCS), particle image sensor (PIS), image remote transmit module and image processing system. Then some details of image processing are discussed. The main advantage of this system is more convenient in particle sample collection and particle image acquisition. The particle size can be obtained using the system with a deviation abot less than 1 μm, and the particle number can be obtained without deviation. The developed system is also convenient and versatile for other analyses of microparticle for academic and industrial application.

  17. Development of an on-line measuring and monitoring system for fouling based on Delphi

    Science.gov (United States)

    Wang, Yuanyuan; Wang, Jianguo

    2010-12-01

    The presence of fouling reduced the heat transfer capability of heat transfer equipments and increased the flow resistance of the medium. Thus the resulting series of economic losses received worldwide attention of the relevant heat transfer industry and countries. For the heating system fouling, direct measurement is nearly impossible. And it is extremely difficulty of structuring mathematic model. Although there are existing monitoring methods, results are not satisfactory. This paper intends to develop a new on-line measuring and monitoring system for heating system fouling. The operating theory of this on-line measuring and monitoring system is based on the soft-sensor technology and Expert System. We select some easily measurements as primary variables, such as pressures, flow rates and temperatures. Through some algorithms, we obtained dozens of secondary variables, for example, the coefficient of flow resistance, the efficiency and cost of heating system and so on. Based on these variables, we construct the knowledge base of this System. This system mainly uses Delphi and Excel as development tools. Now, the system is running well in some heating station, and has reached the expecting result.

  18. Drug repositioning algorithm based on collaborative filtering%基于协同过滤的药物重定位算法

    Institute of Scientific and Technical Information of China (English)

    林耀进; 张佳; 林梦雷; 李进金

    2015-01-01

    Drug repositioning,referring to find new uses for approved drugs or drugs already on the market,has attracted wide attention.In this paper,a novel algorithm of computational drug repositioning based on collaborative filtering is proposed.Firstly,the description information of drugs and diseases are collected to build the incidence matrix of drug-disease,which includes the related information of the indication and side effects of drugs on diseases. Then,according to the incidence matrix of drug-disease,a new measure method is designed to depict the convergence degree between drugs,and this method consides not only the indication similarity,but also the similarity of the side effecs.And then,according to the similarity among drugs,the Top-k similar drugs of the active drug are determined as its neighbors,and these neighbors are used for making the prediction on the target disease.Finally,the mean absolute error and coverage are selected as evaluation metrics to evaluate the prediction quality.Besides,airming at a given disease,the new model of drug repositioning based on collaborative filtering is utilized to predict unrated items of drugs.According to the predictive rating information,we discover potential drugs that have the indication on this disease.Experimental results show that the proposed algorithm can improve the prediction quality for the collaborative filtering system,and can find some therapeutic combinations of drug-disease.Based on this,the conclusion is verified that the proposed algorithm can be applied to drug repositioning effectively.%药物重定位是指发现已上市或批准药物的新用途,受到了广泛的关注。为此,提出一种基于协同过滤的药物重定位算法。首先,收集药物及疾病的描述信息以构建药物―疾病关联矩阵。其次,根据药物对疾病有适应症和有副作用的相关信息,设计了一种刻画药物之间趋同程度的度量方法,该方法同时考虑了不同药物在

  19. Muscle repositioning: combining subjective and objective feedbacks in the teaching and practice of a reflex-based myofascial release technique.

    Science.gov (United States)

    Bertolucci, Luiz Fernando

    2010-03-17

    Muscle Repositioning (MR) is a new style of myofascial release that elicits involuntary motor reactions detectable by electromyography. This article describes the principal theoretical and practical concepts of MR, and summarizes a workshop presented October 31, 2009, after the Second International Fascia Research Congress, held at Vrije Universitiet, Amsterdam.The manual mechanical input of MR integrates the client's body segments into a block, which is evident as a result of the diagnostic manual oscillations the practitioner imparts to the client's body. Segmental integration is achieved when the client's body responds as a unit to the oscillatory assessment. It appears that manually sustaining the condition of segmental integration evokes involuntary muscle reactions, which reactions might correspond to mechanisms that maintain homeostasis, such as pandiculation. It might be that these reactions are part of the MR mechanism of action and underlie its clinically observed efficacy in the treatment of musculoskeletal disorders.For the practitioner and the client alike, segmental integration provides unique sensations. In teaching MR, these paired sensations can be used as kinesthetic feedback resources, because quality of touch can be guided by the client's reported sensations, which should match the practitioner's sensations. Another form of feedback with respect to quality of touch is the visually discernable degree of segmental integration. Finally, because the involuntary motor activity elicited by the MR touch can be objectively monitored through electromyography and possibly other instrumented measurements, the MR approach might yield objectivity, precision, and reproducibility-features seldom found in manual therapies.

  20. [The development of acetylene on-line monitoring technology based on laser absorption spectrum].

    Science.gov (United States)

    He, Ying; Zhang, Yu-jun; Kan, Rui-feng; Xia, Hui; Wang, Min; Cui, Xiao-juan; Chen, Jiu-ying; Chen, Dong; Liu, Wen-qing; Liu, Jian-guo

    2008-10-01

    As one of the materials in organic chemical industry, acetylene has been used in many aspects of chemical industry. But acetylene is a very dangerous inflammable and explosive gas, so it needs in-situ monitoring during industrial storage and production. Tunable diode laser absorption spectroscopy (TDLAS) technology has been widely used in atmospheric trace gases detection, because it has a lot of advantageous characteristics, such as high sensitivity, good selectivity, and rapid time response. The distribution characteristics of absorption lines of acetylene in near infrared band were studied, and then the system designing scheme of acetylene on-line monitoring based on near infrared tunable diode laser absorption spectroscopy technology was discussed in detail. Moreover, the system of experiment measurement was set up and the method of signal detection and the algorithm of concentration inversion were studied. In addition, the sample cell with a path length of 10 cm, and the acetylene of different known concentrations were measured. As a result, the detection limit obtained reached 1.46 cm3 x m(-3). Finally the dynamic detection experiment was carried out, and the measurement result is stable and reliable, so the design of the system is practicable through experiment analysis. On-line acetylene leakage monitoring system was developed based on the experiment, and it is suitable for giving a leakage alarm of acetylene during its storage, transportation and use.

  1. Adaptive control based on an on-line parameter estimation of an upper limb exoskeleton.

    Science.gov (United States)

    Riani, Akram; Madani, Tarek; Hadri, Abdelhafid El; Benallegue, Abdelaziz

    2017-07-01

    This paper presents an adaptive control strategy for an upper-limb exoskeleton based on an on-line dynamic parameter estimator. The objective is to improve the control performance of this system that plays a critical role in assisting patients for shoulder, elbow and wrist joint movements. In general, the dynamic parameters of the human limb are unknown and differ from a person to another, which degrade the performances of the exoskeleton-human control system. For this reason, the proposed control scheme contains a supplementary loop based on a new efficient on-line estimator of the dynamic parameters. Indeed, the latter is acting upon the parameter adaptation of the controller to ensure the performances of the system in the presence of parameter uncertainties and perturbations. The exoskeleton used in this work is presented and a physical model of the exoskeleton interacting with a 7 Degree of Freedom (DoF) upper limb model is generated using the SimMechanics library of MatLab/Simulink. To illustrate the effectiveness of the proposed approach, an example of passive rehabilitation movements is performed using multi-body dynamic simulation. The aims is to maneuver the exoskeleton that drive the upper limb to track desired trajectories in the case of the passive arm movements.

  2. Agent-based station for on-line diagnostics by self-adaptive laser Doppler vibrometry

    Science.gov (United States)

    Serafini, S.; Paone, N.; Castellini, P.

    2013-12-01

    A self-adaptive diagnostic system based on laser vibrometry is proposed for quality control of mechanical defects by vibration testing; it is developed for appliances at the end of an assembly line, but its characteristics are generally suited for testing most types of electromechanical products. It consists of a laser Doppler vibrometer, equipped with scanning mirrors and a camera, which implements self-adaptive bahaviour for optimizing the measurement. The system is conceived as a Quality Control Agent (QCA) and it is part of a Multi Agent System that supervises all the production line. The QCA behaviour is defined so to minimize measurement uncertainty during the on-line tests and to compensate target mis-positioning under guidance of a vision system. Best measurement conditions are reached by maximizing the amplitude of the optical Doppler beat signal (signal quality) and consequently minimize uncertainty. In this paper, the optimization strategy for measurement enhancement achieved by the down-hill algorithm (Nelder-Mead algorithm) and its effect on signal quality improvement is discussed. Tests on a washing machine in controlled operating conditions allow to evaluate the efficacy of the method; significant reduction of noise on vibration velocity spectra is observed. Results from on-line tests are presented, which demonstrate the potential of the system for industrial quality control.

  3. On-Line Model-Based System For Nuclear Plant Monitoring

    Science.gov (United States)

    Tsoukalas, Lefteri H.; Lee, G. W.; Ragheb, Magdi; McDonough, T.; Niziolek, F.; Parker, M.

    1989-03-01

    A prototypical on-line model-based system, LASALLE1, developed at the University of Illinois in collaboration with the Illinois Department of Nuclear Safety (IDNS) is described. Its main purpose is to interpret about 300 signals, updated every two minutes at IDNS from the LaSalle Nuclear Power Plant, and to diagnose possible abnormal conditions. It is written in VAX/VMS OPS5 and operates on both the on-line and testing modes. In its knowledge base, operator and plant actions pertaining to the Emergency Operating Procedure(EOP) A-01, are encoded. This is a procedure driven by a reactor's coolant level and pressure signals; with the purpose of shutting down the reactor, maintaining adequate core cooling and reducing the reactor pressure and temperature to cold shutdown conditions ( about 90 to 200 °F). The monitoring of the procedure is performed from the perspective of Emergency Preparedness. Two major issues are addressed in this system. First, the management of the short-term or working memory of the system. LASALLE1 must reach its inferences, display its conclusion and update a message file every two minutes before a new set of data arrives from the plant. This was achieved by superimposing additional layers of control over the inferencing strategies inherent in OPS5, and developing special rules for the management of the used or outdated information. The second issue is the representation of information and its uncertainty. The concepts of information granularity and performance-level, which are based on a coupling of Probability Theory and the theory of Fuzzy Sets, are used for this purpose. The estimation of the performance-level incorporates a mathematical methodology which accounts for two types of uncertainty encountered in monitoring physical systems: Random uncertainty, in the form of of probability density functions generated by observations, measurements and sensors data and fuzzy uncertainty represented by membership functions based on symbolic

  4. On-line grid impedance estimation based on harmonic injection for grid-connected PV inverter

    DEFF Research Database (Denmark)

    Ciobotaru, Mihai; Teodorescu, Remus; Blaabjerg, Frede

    2007-01-01

    The paper presents an on-line software method for impedance estimation of the energized impedances such as power system grid. The proposed method is based on producing a perturbation on the output of the power converter that is in the form of periodical injection of one or two voltage harmonic...... two different signal processing algorithms. The DFT technique is used for the single harmonic injection and the statistic technique is used for the double harmonic injection. The grid impedance estimation is used for compliance with the anti-islanding requirements of the German standard (VDE0126...... signals. The single harmonic injection uses a 600 Hz signal and the double harmonic injection uses a 400 Hz and 600 Hz signals, respectively. During the perturbation, the current response(s) at the same frequency as the injected signal(s) is/are measured. The value of the grid impedance is estimated using...

  5. An on-line remote supervisory system for microparticles based on image analysis

    Institute of Scientific and Technical Information of China (English)

    LIU Wei-hua; JIANG Ming-shun; SUI Qing-mei

    2011-01-01

    A new on-line remote particle analysis system based on image processing has been developed to measure microparticles.The system is composed of particle collector sensor (PCS),particle image sensor (PIS),image remote wansmit module and image processing system.Then some details of image processing are discussed.The main advantage of this system is more convenient in particle sample collection and particle image acquisition.The particle size can be obtained using the system with a deviation abot less than 1 μm,and the particle number can be obtained without deviation,The developed system is also convenient and versatile for other analyses of microparticle for academic and industrial application.

  6. A systematic method based on statistical pattern recognition for estimating product quality on-line

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    To avoid the complexity of building mechanistic models by studying the inner nature of the object, a systematic method based on statistical pattern recognition is developed in order to estimate the product quality on-lipe. The mapping relationship between a feature space and a product quality space can be built by using regression analysis, and in applying clustering analysis the product quality space can be partitioned automatically. Eventually, estimating product quality on-line can be accomplished by sorting the mapped data in the partitioned quality space. A concrete problem is proposed which has a relatively small ratio of training data to input variables. By implementing the method mentioned above, a satisfying result has been achieved. Furthermore, the further question about choosing suitable mapping methods is briefly discussed.

  7. Research on a Lamb Wave and Particle Filter-Based On-Line Crack Propagation Prognosis Method.

    Science.gov (United States)

    Chen, Jian; Yuan, Shenfang; Qiu, Lei; Cai, Jian; Yang, Weibo

    2016-03-03

    Prognostics and health management techniques have drawn widespread attention due to their ability to facilitate maintenance activities based on need. On-line prognosis of fatigue crack propagation can offer information for optimizing operation and maintenance strategies in real-time. This paper proposes a Lamb wave-particle filter (LW-PF)-based method for on-line prognosis of fatigue crack propagation which takes advantages of the possibility of on-line monitoring to evaluate the actual crack length and uses a particle filter to deal with the crack evolution and monitoring uncertainties. The piezoelectric transducers (PZTs)-based active Lamb wave method is adopted for on-line crack monitoring. The state space model relating to crack propagation is established by the data-driven and finite element methods. Fatigue experiments performed on hole-edge crack specimens have validated the advantages of the proposed method.

  8. Research on a Lamb Wave and Particle Filter-Based On-Line Crack Propagation Prognosis Method

    Directory of Open Access Journals (Sweden)

    Jian Chen

    2016-03-01

    Full Text Available Prognostics and health management techniques have drawn widespread attention due to their ability to facilitate maintenance activities based on need. On-line prognosis of fatigue crack propagation can offer information for optimizing operation and maintenance strategies in real-time. This paper proposes a Lamb wave-particle filter (LW-PF-based method for on-line prognosis of fatigue crack propagation which takes advantages of the possibility of on-line monitoring to evaluate the actual crack length and uses a particle filter to deal with the crack evolution and monitoring uncertainties. The piezoelectric transducers (PZTs-based active Lamb wave method is adopted for on-line crack monitoring. The state space model relating to crack propagation is established by the data-driven and finite element methods. Fatigue experiments performed on hole-edge crack specimens have validated the advantages of the proposed method.

  9. The Liner Shipping Fleet Repositioning Problem with Cargo Flows

    DEFF Research Database (Denmark)

    Tierney, Kevin; Jensen, Rune Møller

    2012-01-01

    We solve an important problem for the liner shipping industry called the Liner Shipping Fleet Repositioning Problem (LSFRP). The LSFRP poses a large financial burden on liner shipping firms. During repositioning, vessels are moved between services in a liner shipping network. Shippers wish...... in the literature. We introduce a novel mathematical model of the LSFRP with cargo flows based on a carefully constructed graph and evaluate it on real world data from our industrial collaborator....

  10. Analyze On-line Star Economy Basing on Models of Entrepreneurship

    Institute of Scientific and Technical Information of China (English)

    胡志豪

    2016-01-01

    The outstanding performance of the On-line Star Economy is bound up with social media and promotion by fans, stimulating a new round of consumption upgrading and capital tendency. There is no denying that the On-line Star Economy may be the fortuitous outcome of the times. But the fact remains it can be analyzed rationally using Models of Entrepreneurship.

  11. Test of on-line alkali detector based on surface ionisation technique

    Energy Technology Data Exchange (ETDEWEB)

    Wiktorsson, L.-P.A.; Sjoestroem, L.K. [Chemical Technology, Stockholm (Sweden). Dept. of Chemical Engineering and Technology

    1998-12-31

    The objective of this project is to test on-line alkali metal measuring equipment in a reducing atmosphere. The equipment is based on surface ionisation (SI) technique. The tests have taken place in reactors of varying sizes, from mg per batch to continuous feeding of kg/h, non-pressurised and pressurised. On-line alkali metal detector prototypes have been tested in real gases at atmospheric and elevated pressure. The primary parts of the detector prototypes are a platinum filament and an ion collector. The first prototype (A) of the surface ionisation detector was tested in a mg-scale pyrolysis reactor, a so-called Pyrojector, by introducing the coal sample with a `pelletizer`. The generated detector signal, a current in the pA to {mu}A range, was directly proportional to the sample weight. The second prototype (B) of the surface ionisation detector was tested in a very tarry gas flow, 20 g tar/Nm{sup 3}, at atmospheric pressure in a continuously fed g/min-scale biomass pyrolysis apparatus. The generated detector signal, a current in the {mu}A range, was measured by a picoammeter and sampled on a computer. The feedstocks were pine and birch and straw. A third prototype (D) of the surface ionisation detector was tested during pressurised gasification in a fluidised bed reactor. The feedstock was birch. The prototype detected alkali in the gas, though the temperature was only 773-793 K in the vicinity of the detector. The filament temperature control has to be further developed and tested. 1 ref., 19 figs., 6 tabs.

  12. Event-based plausibility immediately influences on-line language comprehension.

    Science.gov (United States)

    Matsuki, Kazunaga; Chow, Tracy; Hare, Mary; Elman, Jeffrey L; Scheepers, Christoph; McRae, Ken

    2011-07-01

    In some theories of sentence comprehension, linguistically relevant lexical knowledge, such as selectional restrictions, is privileged in terms of the time-course of its access and influence. We examined whether event knowledge computed by combining multiple concepts can rapidly influence language understanding even in the absence of selectional restriction violations. Specifically, we investigated whether instruments can combine with actions to influence comprehension of ensuing patients of (as in Rayner, Warren, Juhuasz, & Liversedge, 2004; Warren & McConnell, 2007). Instrument-verb-patient triplets were created in a norming study designed to tap directly into event knowledge. In self-paced reading (Experiment 1), participants were faster to read patient nouns, such as hair, when they were typical of the instrument-action pair (Donna used the shampoo to wash vs. the hose to wash). Experiment 2 showed that these results were not due to direct instrument-patient relations. Experiment 3 replicated Experiment 1 using eyetracking, with effects of event typicality observed in first fixation and gaze durations on the patient noun. This research demonstrates that conceptual event-based expectations are computed and used rapidly and dynamically during on-line language comprehension. We discuss relationships among plausibility and predictability, as well as their implications. We conclude that selectional restrictions may be best considered as event-based conceptual knowledge rather than lexical-grammatical knowledge.

  13. Model-based evaluation of an on-line control strategy for SBRs based on OUR and ORP measurements.

    Science.gov (United States)

    Corominas, Ll; Sin, G; Puig, S; Traore, A; Balaguer, M; Colprim, J; Vanrolleghem, P A

    2006-01-01

    Application of control strategies for existing wastewater treatment technologies becomes necessary to meet ever-stricter effluent legislations and reduce the associated treatment costs. In the case of SBR technology, controlling the phase scheduling is one of the key aspects of SBR operation. In this study a calibrated mechanistic model based on the ASM1 was used to evaluate an on-line control strategy for the SBR phase-scheduling and compare it with the SBR's performance using no control strategy. To evaluate the performance, reference indices relating to the effluent quality, the required energy for aeration and the treated wastewater volume were used. The results showed that it is possible to maintain optimal SBR performance in the studied system at minimal costs by on-line control of the length of the aerobic and anoxic phases.

  14. Explicit Drug Re-positioning: Predicting Novel Drug-Target Interactions of the Shelved Molecules with QM/MM Based Approaches.

    Science.gov (United States)

    Omer, Ankur; Suryanarayanan, Venkatesan; Selvaraj, Chandrabose; Singh, Sanjeev Kumar; Singh, Poonam

    2015-01-01

    With the demand to enhance the speed of the drug discovery process there has been an increased usage of computational approaches in drug discovery studies. However because of their probabilistic outcomes, the challenge is to exactly mimic the natural environment which can provide the exact charge polarization effect while estimating the binding energy between protein and ligand. There has been a large number of scoring functions from simple one to the complex one available for estimating binding energy. The quantum mechanics/molecular mechanics (QM/MM) hybrid approach has been the preferred choice of interest since last decade for modeling reactions in biomolecular systems. The application of QM/MM approach has been expanded right from rescoring the already known complexes and depicting the correct position of some novel molecule to ranking a large number of molecules. It is expected that the application of QM/MM-based scoring will grow in all areas of drug discovery. However, the most promising area will be its application in repositioning, that is, assigning novel functions or targets to the already existing drugs, as this would stop the rising attrition rates as well as reduce the overall time and cost of drug discovery procedure. © 2015 Elsevier Inc. All rights reserved.

  15. Moving object detection based on on-line block-robust principal component analysis decomposition

    Science.gov (United States)

    Yang, Biao; Cao, Jinmeng; Zou, Ling

    2017-07-01

    Robust principal component analysis (RPCA) decomposition is widely applied in moving object detection due to its ability in suppressing environmental noises while separating sparse foreground from low rank background. However, it may suffer from constant punishing parameters (resulting in confusion between foreground and background) and holistic processing of all input frames (leading to bad real-time performance). Improvements to these issues are studied in this paper. A block-RPCA decomposition approach was proposed to handle the confusion while separating foreground from background. Input frame was initially separated into blocks using three-frame difference. Then, punishing parameter of each block was computed by its motion saliency acquired based on selective spatio-temporal interesting points. Aiming to improve the real-time performance of the proposed method, an on-line solution to block-RPCA decomposition was utilized. Both qualitative and quantitative tests were implemented and the results indicate the superiority of our method to some state-of-the-art approaches in detection accuracy or real-time performance, or both of them.

  16. On-line metabolic pathway analysis based on metabolic signal flow diagram.

    Science.gov (United States)

    Shi, H; Shimizu, K

    In this work, an integrated modeling approach based on a metabolic signal flow diagram and cellular energetics was used to model the metabolic pathway analysis for the cultivation of yeast on glucose. This approach enables us to make a clear analysis of the flow direction of the carbon fluxes in the metabolic pathways as well as of the degree of activation of a particular pathway for the synthesis of biomaterials for cell growth. The analyses demonstrate that the main metabolic pathways of Saccharomyces cerevisiae change significantly during batch culture. Carbon flow direction is toward glycolysis to satisfy the increase of requirement for precursors and energy. The enzymatic activation of TCA cycle seems to always be at normal level, which may result in the overflow of ethanol due to its limited capacity. The advantage of this approach is that it adopts both virtues of the metabolic signal flow diagram and the simple network analysis method, focusing on the investigation of the flow directions of carbon fluxes and the degree of activation of a particular pathway or reaction loop. All of the variables used in the model equations were determined on-line; the information obtained from the calculated metabolic coefficients may result in a better understanding of cell physiology and help to evaluate the state of the cell culture process. Copyright 1998 John Wiley & Sons, Inc.

  17. On-line Monitoring System based on Vibration Signal of High Voltage Circuit Breaker

    Directory of Open Access Journals (Sweden)

    Chao Fu

    2014-04-01

    Full Text Available High voltage circuit breaker is one of the most important switch apparatus in electrical power system. It play a role in the switch control, which can be used to switch the operating mode during normal operation (the equipment run or quit. In order to ensure the normal operation of the grid, it can be removed quickly when a malfunction on the device or circuit. Real-time online monitoring of high voltage circuit breaker can understand the running status, master the operation characteristics and its tend of development. As early as possible find the potential faults then take preventive measures timely, so as to ensure the reliable operation of power system. Online monitoring of high voltage circuit breakers can reduce the premature or unnecessary maintenance and maintenance cost, improve pertinence of the maintenance firstly. Secondly, it can improve the life of the switching device and improve the reliability of electric power system significantly. In this paper, on-line monitoring system based on vibration signal of high voltage circuit breaker is presented

  18. On-line prognosis of fatigue crack propagation based on Gaussian weight-mixture proposal particle filter.

    Science.gov (United States)

    Chen, Jian; Yuan, Shenfang; Qiu, Lei; Wang, Hui; Yang, Weibo

    2017-07-25

    Accurate on-line prognosis of fatigue crack propagation is of great meaning for prognostics and health management (PHM) technologies to ensure structural integrity, which is a challenging task because of uncertainties which arise from sources such as intrinsic material properties, loading, and environmental factors. The particle filter algorithm has been proved to be a powerful tool to deal with prognostic problems those are affected by uncertainties. However, most studies adopted the basic particle filter algorithm, which uses the transition probability density function as the importance density and may suffer from serious particle degeneracy problem. This paper proposes an on-line fatigue crack propagation prognosis method based on a novel Gaussian weight-mixture proposal particle filter and the active guided wave based on-line crack monitoring. Based on the on-line crack measurement, the mixture of the measurement probability density function and the transition probability density function is proposed to be the importance density. In addition, an on-line dynamic update procedure is proposed to adjust the parameter of the state equation. The proposed method is verified on the fatigue test of attachment lugs which are a kind of important joint components in aircraft structures. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. Evaluation of Repositioning in Pressure Ulcer Prevention

    OpenAIRE

    Källman, Ulrika

    2015-01-01

    Introduction: To reduce the risk for pressure ulcers, repositioning of immobile patients is an important standard nursing practice. However, knowledge on how this preventive intervention is carried out among elderly immobile patients is limited and to what extent patients perform minor movements between nursing staff-induced repositionings is largely unknown, but these movements might have implications for the repositioning intervention. Different lying positions are used in repositioning sch...

  20. On-line detecting of transformer winding deformation based on parameter identification of leakage inductance

    Institute of Scientific and Technical Information of China (English)

    Hao Zhiguo; Zhang Baohui; Li Peng

    2007-01-01

    Transformers are required to demonstrate the ability to withstand short circuit currents. Over currents caused by short circuit can give rise to windings deformation. In this paper, a novel method is proposed to monitor the state of transformer windings, which is achieved through on-line detecting the leakage inductance of the windings. Specifically, the mathematical model is established for on-line identifying the leakage inductance of the windings by applying least square algorithm (LSA) to the equivalent circuit equations. The effect of measurement and model inaccuracy on the identification error is analyzed, and the corrected model is also given to decrease these adverse effect on the results. Finally, dynamic test is carried out to verify our method. The test results clearly show that our method is very accurate even under the fluctuation of load or power factor. Therefore, our method can be effectively used to on-line detect the windings deformation.

  1. Force-reflecting teleoperation of robots based on on-line correction of a virtual model

    Institute of Scientific and Technical Information of China (English)

    LIU Wei; SONG Aiguo; LI Huijun

    2007-01-01

    Virtual reality is an effective method to eliminate the influence of time delay.However,it depends on the precision of the virtual model.In this paper,we introduce a method that corrects the virtual model on-line to establish a more precise model.The geometric errors of the virtual model were corrected on-line by overlapping the graphics over the images and also by syncretizing the position and force information from the remote.Then the sliding average least squares (SALS)method was adopted to determine the mass,damp,and stiffness of the remote environment and use this information to amend the dynamic model of the environment.Experimental results demonstrate that the on-line correction method we proposed can effectively reduce the impact caused by time delay,and improve the operational performance of the teleoperation system.

  2. On-Line Fast Motor Fault Diagnostics Based on Fuzzy Neural Networks

    Institute of Scientific and Technical Information of China (English)

    DONG Mingchui; CHEANG Takson; CHAN Sileong

    2009-01-01

    An on-line method was developed to improve diagnostic accuracy and speed for analyzing run-ning motors on site. On-line pre-measured data was used as the basis for constructing the membership functions used in a fuzzy neural network (FNN) as well as for network training to reduce the effects of vari-ous static factors, such as unbalanced input power and asymmetrical motor alignment, to increase accuracy.The preprocessed data and fuzzy logic were used to find the nonlinear mapping relationships between the data and the conclusions. The FNN was then constructed to carry motor fault diagnostics, which gives fast accurate diagnostics. The on-line fast motor fault diagnostics clearly indicate the fault type, location, and severity in running motors. This approach can also be extended to other applications.

  3. ON-LINE STATE PREDICTION OF ENGINES BASED ON FLAT NEURAL NETWORK

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    A flat neural network is designed for the on-line state prediction of engine. To reduce the computational cost of weight matrix, a fast recursive algorithm is derived according to the pseudoinverse formula of a partition matrix. Furthermore, the forgetting factor approach is introduced to improve predictive accuracy and robustness of the model. The experiment results indicate that the improved neural network is of good accuracy and strong robustness in prediction, and can apply for the on-line prediction of nonlinear multi input multi output systems like vehicle engines.

  4. Digital signal processor-based high-precision on-line Voigt lineshape fitting for direct absorption spectroscopy.

    Science.gov (United States)

    Xu, Lijun; Liu, Chang; Zheng, Deyan; Cao, Zhang; Cai, Weiwei

    2014-12-01

    To realize on-line high-accuracy measurement in direct absorption spectroscopy (DAS), a system-on-chip, high-precision digital signal processor-based on-line Voigt lineshape fitting implementation is introduced in this paper. Given that the Voigt lineshape is determined by the Gauss full width at half maximum (FWHM) and Lorentz FWHM, a look-up table, which covers a range of combinations of both, is first built to achieve rapid and accurate calculation of Voigt lineshape. With the look-up table and raw absorbance data in hand, Gauss-Newton nonlinear fitting module is implemented to obtain the parameters including both the Gauss and Lorentz FWHMs, which can be used to calculate the integrated absorbance. To realize the proposed method in hardware, a digital signal processor (DSP) is adopted to fit the Voigt lineshape in a real-time DAS measurement system. In experiment, temperature and H2O concentration of a flat flame are recovered from the transitions of 7444.36 cm(-1) and 7185.6 cm(-1) by the DSP-based on-line Voigt lineshape fitting and on-line integral of the raw absorbance, respectively. The results show that the proposed method can not only fit the Voigt lineshape on-line but also improve the measurement accuracy compared with those obtained from the direct integral of the raw absorbance.

  5. Comparison and Contrast of Paper-based and On-line Dictionaries

    Institute of Scientific and Technical Information of China (English)

    王雪

    2014-01-01

    This paper explores the advantages and disadvantages of paper printed and on-line dictionaries in terms of macrostruc-ture and microstructure, availability, portability and practicality etc. Different kinds of dictionaries have unique features that can-not be fully replaced by other kinds.

  6. On-line blind source separation algorithm based on second order statistics

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    An on-line blind source separation (BSS) algorithm is presented in this paper under the assumption that sources are temporarily correlated signals. By using only some of the observed samples in a recursive calculation, the whitening matrix and the rotation matrix could be approximately obtained through the measurement of only one cost function. Simulations show good performance of the algorithm.

  7. Simple chip-based interfaces for on-line monitoring of supramolecular interactions by nano-ESI MS

    NARCIS (Netherlands)

    Brivio, M.; Oosterbroek, R.E.; Verboom, Willem; van den Berg, Albert; Reinhoudt, David

    2005-01-01

    Two simple interfaces were designed and realized, enabling on-line coupling of microfluidics reactor chips to a nanoflow electrospray ionization (NESI) time-of-flight (TOF) mass spectrometer (MS). The interfaces are based on two different approaches: a monolithically integrated design, in which

  8. APPROACH TO FAULT ON-LINE DETECTION AND DIAGNOSIS BASED ON NEURAL NETWORKS FOR ROBOT IN FMS

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    Based on radial basis function (RBF) neural networks, the healthy working model of each sub-system of robot in FMS is established. A new approach to fault on-line detection and diagnosis according to neural networks model is presented. Fault double detection based on neural network model and threshold judgement and quick fault identification based on multi-layer feedforward neural networks are applied, which can meet quickness and reliability of fault detection and diagnosis for robot in FMS.

  9. Repositioning the substrate activity screening (SAS) approach as a fragment-based method for identification of weak binders.

    Science.gov (United States)

    Gladysz, Rafaela; Cleenewerck, Matthias; Joossens, Jurgen; Lambeir, Anne-Marie; Augustyns, Koen; Van der Veken, Pieter

    2014-10-13

    Fragment-based drug discovery (FBDD) has evolved into an established approach for "hit" identification. Typically, most applications of FBDD depend on specialised cost- and time-intensive biophysical techniques. The substrate activity screening (SAS) approach has been proposed as a relatively cheap and straightforward alternative for identification of fragments for enzyme inhibitors. We have investigated SAS for the discovery of inhibitors of oncology target urokinase (uPA). Although our results support the key hypotheses of SAS, we also encountered a number of unreported limitations. In response, we propose an efficient modified methodology: "MSAS" (modified substrate activity screening). MSAS circumvents the limitations of SAS and broadens its scope by providing additional fragments and more coherent SAR data. As well as presenting and validating MSAS, this study expands existing SAR knowledge for the S1 pocket of uPA and reports new reversible and irreversible uPA inhibitor scaffolds.

  10. Nucleosome repositioning via loop formation

    CERN Document Server

    Kulic, M L

    2002-01-01

    Active (catalysed) and passive (intrinsic) nucleosome repositioning is known to be a crucial event during the transcriptional activation of certain eucaryotic genes. Here we consider theoretically the intrinsic mechanism and study in detail the energetics and dynamics of DNA-loop-mediated nucleosome repositioning, as previously proposed by Schiessel et al. (H. Schiessel, J. Widom, R. F. Bruinsma, and W. M. Gelbart. 2001. {\\it Phys. Rev. Lett.} 86:4414-4417). The surprising outcome of the present study is the inherent nonlocality of nucleosome motion within this model -- being a direct physical consequence of the loop mechanism. On long enough DNA templates the longer jumps dominate over the previously predicted local motion, a fact that contrasts simple diffusive mechanisms considered before. The possible experimental outcome resulting from the considered mechanism is predicted, discussed and compared to existing experimental findings.

  11. Laser measurement and analysis of reposition error in polishing systems

    Science.gov (United States)

    Liu, Weisen; Wang, Junhua; Xu, Min; He, Xiaoying

    2015-10-01

    In this paper, robotic reposition error measurement method based on laser interference remote positioning is presented, the geometric error is analyzed in the polishing system based on robot and the mathematical model of the tilt error is presented. Studies show that less than 1 mm error is mainly caused by the tilt error with small incident angle. Marking spot position with interference fringe enhances greatly the error measurement precision, the measurement precision of tilt error can reach 5 um. Measurement results show that reposition error of the polishing system is mainly from the tilt error caused by the motor A, repositioning precision is greatly increased after polishing system improvement. The measurement method has important applications in the actual error measurement with low cost, simple operation.

  12. Drug repositioning for orphan diseases.

    Science.gov (United States)

    Sardana, Divya; Zhu, Cheng; Zhang, Minlu; Gudivada, Ranga C; Yang, Lun; Jegga, Anil G

    2011-07-01

    The need and opportunity to discover therapeutics for rare or orphan diseases are enormous. Due to limited prevalence and/or commercial potential, of the approximately 6000 orphan diseases (defined by the FDA Orphan Drug Act as industry. The fact that drug development is complicated, time-consuming and expensive with extremely low success rates only adds to the low rate of therapeutics available for orphan diseases. An alternative and efficient strategy to boost the discovery of orphan disease therapeutics is to find connections between an existing drug product and orphan disease. Drug Repositioning or Drug Repurposing--finding a new indication for a drug--is one way to maximize the potential of a drug. The advantages of this approach are manifold, but rational drug repositioning for orphan diseases is not trivial and poses several formidable challenges--pharmacologically and computationally. Most of the repositioned drugs currently in the market are the result of serendipity. One reason the connection between drug candidates and their potential new applications are not identified in an earlier or more systematic fashion is that the underlying mechanism 'connecting' them is either very intricate and unknown or indirect or dispersed and buried in an ever-increasing sea of information, much of which is emerging only recently and therefore is not well organized. In this study, we will review some of these issues and the current methodologies adopted or proposed to overcome them and translate chemical and biological discoveries into safe and effective orphan disease therapeutics.

  13. On-line Dynamic Model Correction Based Fault Diagnosis in Chemical Processes

    Institute of Scientific and Technical Information of China (English)

    田文德; 孙素莉

    2007-01-01

    A novel fault detection and diagnosis method was proposed,using dynamic simulation to monitor chemical process and identify faults when large tracking deviations occur.It aims at parameter failures,and the parameters are updated via on-line correction.As it can predict the trend of process and determine the existence of malfunctions simultaneously,this method does not need to design problem-specific observer to estimate unmeasured state variables.Application of the proposed method is presented on one water tank and one aromatization reactor,and the results are compared with those from the traditional method.

  14. On-line Detection of Gas Pipeline Based on the Real-Time Algorithm and Network Technology with Robot

    Institute of Scientific and Technical Information of China (English)

    YAN Bo; YAN Guo-zheng; DING Guo-qing; ZHOU Bing; FU Xi-guang; ZUO Jian-yong

    2004-01-01

    The detection system integrates control technology, network technology, video encoding and decoding, video transmiss-ion, multi-single chip microcomputer communication, dat-abase technology, computer software and robot technology. The robot can adaptively adjust its status according to diameter (from 400 mm to 650 mm) of pipeline. The maximum detection distance is up to 1 000 m. The method of video coding in the system is based on fractal transformation. The experiments show that the coding scheme is fast and good PSNR. The precision of on-line detection is up to 3% thickness of pipeline wall. The robot can also have a high precision of location up to 0.03 m. The control method is based on network and characterized by on-line and real-time. The experiment in real gas pipeline shows that the performance of the detection system is good.

  15. Strategic Corporate Communication dalam Proses Repositioning dan Rebranding

    Directory of Open Access Journals (Sweden)

    Prayudi .

    2013-12-01

    Full Text Available Abstract: Global competition, price war, and fast growing of technology are among crucial factors that companies have to face as opportunities instead of constraints. Companies must adapt with changes based on vision and mission taht have been stated. Often, repositioning and rebranding has to be done in order to increase competitive advantage and strengthen compnany idnetity in the market place. Eventually, it is expected that companies’ stakeholders always aware and loyal towards product and company brands. This article examines the understanding of repositioning and rebranding within the context of strategic coprorate communication function.

  16. FPGA implementation of a hybrid on-line process monitoring in PC based real-time systems

    Directory of Open Access Journals (Sweden)

    Jovanović Bojan

    2011-01-01

    Full Text Available This paper presents one way of FPGA implementation of hybrid (hardware-software based on-line process monitoring in Real-Time systems (RTS. The reasons for RTS monitoring are presented at the beginning. The summary of different RTS monitoring approaches along with its advantages and drawbacks are also exposed. Finally, monitoring module is described in details. Also, FPGA implementation results and some useful monitoring system applications are mentioned.

  17. On-Line Multi-Damage Scanning Spatial-Wavenumber Filter Based Imaging Method for Aircraft Composite Structure

    Directory of Open Access Journals (Sweden)

    Yuanqiang Ren

    2017-05-01

    Full Text Available Structural health monitoring (SHM of aircraft composite structure is helpful to increase reliability and reduce maintenance costs. Due to the great effectiveness in distinguishing particular guided wave modes and identifying the propagation direction, the spatial-wavenumber filter technique has emerged as an interesting SHM topic. In this paper, a new scanning spatial-wavenumber filter (SSWF based imaging method for multiple damages is proposed to conduct on-line monitoring of aircraft composite structures. Firstly, an on-line multi-damage SSWF is established, including the fundamental principle of SSWF for multiple damages based on a linear piezoelectric (PZT sensor array, and a corresponding wavenumber-time imaging mechanism by using the multi-damage scattering signal. Secondly, through combining the on-line multi-damage SSWF and a PZT 2D cross-shaped array, an image-mapping method is proposed to conduct wavenumber synthesis and convert the two wavenumber-time images obtained by the PZT 2D cross-shaped array to an angle-distance image, from which the multiple damages can be directly recognized and located. In the experimental validation, both simulated multi-damage and real multi-damage introduced by repeated impacts are performed on a composite plate structure. The maximum localization error is less than 2 cm, which shows good performance of the multi-damage imaging method. Compared with the existing spatial-wavenumber filter based damage evaluation methods, the proposed method requires no more than the multi-damage scattering signal and can be performed without depending on any wavenumber modeling or measuring. Besides, this method locates multiple damages by imaging instead of the geometric method, which helps to improve the signal-to-noise ratio. Thus, it can be easily applied to on-line multi-damage monitoring of aircraft composite structures.

  18. On-Line Multi-Damage Scanning Spatial-Wavenumber Filter Based Imaging Method for Aircraft Composite Structure.

    Science.gov (United States)

    Ren, Yuanqiang; Qiu, Lei; Yuan, Shenfang; Bao, Qiao

    2017-05-11

    Structural health monitoring (SHM) of aircraft composite structure is helpful to increase reliability and reduce maintenance costs. Due to the great effectiveness in distinguishing particular guided wave modes and identifying the propagation direction, the spatial-wavenumber filter technique has emerged as an interesting SHM topic. In this paper, a new scanning spatial-wavenumber filter (SSWF) based imaging method for multiple damages is proposed to conduct on-line monitoring of aircraft composite structures. Firstly, an on-line multi-damage SSWF is established, including the fundamental principle of SSWF for multiple damages based on a linear piezoelectric (PZT) sensor array, and a corresponding wavenumber-time imaging mechanism by using the multi-damage scattering signal. Secondly, through combining the on-line multi-damage SSWF and a PZT 2D cross-shaped array, an image-mapping method is proposed to conduct wavenumber synthesis and convert the two wavenumber-time images obtained by the PZT 2D cross-shaped array to an angle-distance image, from which the multiple damages can be directly recognized and located. In the experimental validation, both simulated multi-damage and real multi-damage introduced by repeated impacts are performed on a composite plate structure. The maximum localization error is less than 2 cm, which shows good performance of the multi-damage imaging method. Compared with the existing spatial-wavenumber filter based damage evaluation methods, the proposed method requires no more than the multi-damage scattering signal and can be performed without depending on any wavenumber modeling or measuring. Besides, this method locates multiple damages by imaging instead of the geometric method, which helps to improve the signal-to-noise ratio. Thus, it can be easily applied to on-line multi-damage monitoring of aircraft composite structures.

  19. On-line forecasting model for zinc output based on self-tuning support vector regression and its application

    Institute of Scientific and Technical Information of China (English)

    胡志坤; 桂卫华; 彭小奇

    2004-01-01

    An on-line forecasting model based on self-tuning support vectors regression for zinc output was put forward to maximize zinc output by adjusting operational parameters in the process of imperial smelting furnace. In this model, the mathematical model of support vector regression was converted into the same format as support vector machine for classification. Then a simplified sequential minimal optimization for classification was applied to train the regression coefficient vector α- α* and threshold b. Sequentially penalty parameter C was tuned dynamically through forecasting result during the training process. Finally, an on-line forecasting algorithm for zinc output was proposed. The simulation result shows that in spite of a relatively small industrial data set, the effective error is less than 10% with a remarkable performance of real time. The model was applied to the optimization operation and fault diagnosis system for imperial smelting furnace.

  20. Reversed-phase liquid chromatography coupled on-line to estrogen receptor bioaffinity detection based on fluorescence polarization.

    Science.gov (United States)

    Reinen, Jelle; Kool, Jeroen; Vermeulen, Nico P E

    2008-04-01

    We describe the development and validation of a high-resolution screening (HRS) platform which couples gradient reversed-phase high-performance liquid chromatography (RP-HPLC) on-line to estrogen receptor alpha (ERalpha) affinity detection using fluorescence polarization (FP). FP, which allows detection at high wavelengths, limits the occurrence of interference from the autofluorescence of test compounds in the bioassay. A fluorescein-labeled estradiol derivative (E2-F) was synthesized and a binding assay was optimized in platereader format. After subsequent optimization in flow-injection analysis (FIA) mode, the optimized parameters were translated to the on-line HRS bioassay. Proof of principle was demonstrated by separating a mixture of five compounds known to be estrogenic (17beta-estradiol, 17alpha-ethinylestradiol and the phytoestrogens coumestrol, coumarol and zearalenone), followed by post-column bioaffinity screening of the individual affinities for ERalpha. Using the HRS-based FP setup, we were able to screen affinities of off-line-generated metabolites of zearalenone for ERalpha. It is concluded that the on-line FP-based bioassay can be used to screen for the affinity of compounds without the disturbing occurrence of autofluorescence.

  1. On-line surface inspection using cylindrical lens-based spectral domain low-coherence interferometry.

    Science.gov (United States)

    Tang, Dawei; Gao, Feng; Jiang, X

    2014-08-20

    We present a spectral domain low-coherence interferometry (SD-LCI) method that is effective for applications in on-line surface inspection because it can obtain a surface profile in a single shot. It has an advantage over existing spectral interferometry techniques by using cylindrical lenses as the objective lenses in a Michelson interferometric configuration to enable the measurement of long profiles. Combined with a modern high-speed CCD camera, general-purpose graphics processing unit, and multicore processors computing technology, fast measurement can be achieved. By translating the tested sample during the measurement procedure, real-time surface inspection was implemented, which is proved by the large-scale 3D surface measurement in this paper. ZEMAX software is used to simulate the SD-LCI system and analyze the alignment errors. Two step height surfaces were measured, and the captured interferograms were analyzed using a fast Fourier transform algorithm. Both 2D profile results and 3D surface maps closely align with the calibrated specifications given by the manufacturer.

  2. Drug repositioning for treatment of movement disorders: from serendipity to rational discovery strategies.

    Science.gov (United States)

    Bolgár, Bence; Arany, Ádám; Temesi, Gergely; Balogh, Balázs; Antal, Péter; Mátyus, Péter

    2013-01-01

    Movement disorders are a heterogeneous group of both common and rare neurological conditions characterized by abnormalities of motor functions and movement patterns. This work overviews recent successes and ongoing studies of repositioning relating to this disease group, which underscores the challenge of integrating the voluminous and heterogeneous findings required for making suitable drug repositioning decisions. In silico drug repositioning methods hold the promise of automated fusion of heterogeneous information sources, but the controllable, flexible and transparent incorporation of the expertise of medicinal chemists throughout the repositioning process remains an open challenge. In support of a more systematic approach toward repositioning, we summarize the application of a computational repurposing method based on statistically rooted knowledge fusion. To foster the spread of this technique, we provide a step-by-step guide to the complete workflow, together with a case study in Parkinson's disease.

  3. Automated Planning for Liner Shipping Fleet Repositioning

    DEFF Research Database (Denmark)

    Tierney, Kevin; Jensen, Rune Møller; Kroer, Christian

    2012-01-01

    The Liner Shipping Fleet Repositioning Problem (LSFRP) poses a large financial burden on liner shipping firms. During repositioning, vessels are moved between services in a liner shipping network. The LSFRP is characterized by chains of interacting activities, many of which have costs...

  4. On-line Multiple-model Based Adaptive Control Reconfiguration for a Class of Non-linear Control Systems

    DEFF Research Database (Denmark)

    Yang, Z.; Izadi-Zamanabadi, Roozbeh; Blanke, M.

    2000-01-01

    Based on the model-matching strategy, an adaptive control reconfiguration method for a class of nonlinear control systems is proposed by using the multiple-model scheme. Instead of requiring the nominal and faulty nonlinear systems to match each other directly in some proper sense, three sets...... of LTI models are employed to approximate the faulty, reconfigured and nominal nonlinear systems respectively with respect to the on-line information of the operating system, and a set of compensating modules are proposed and designed so as to make the local LTI model approximating to the reconfigured...

  5. Repositioning Strategy for Malaysian Companies Internationalization

    Directory of Open Access Journals (Sweden)

    Ismi Rajiani

    2013-04-01

    Full Text Available The rise of the emerging-market countries offers both developing and developed countries a unique opportunity to gain the benefits of a truly international economy. Consequently, it is imper- ative to advance our knowledge of emerging-market countries MNC emergence and competitive- ness including Malaysian firms on how will they position their products strategically. Based on the framework of Porter’s Generic Strategy, this paper is composed of price/ volume segments and im- pacts on product strategy theory. The aim is to identify crucial triggering cues and focus areas for Malaysian companies and measure what role these play in different segments. This study argues that some Malaysian companies will reposition themselves strategically when internationalizing and that they will focus on other factors or triggering cues when doing so not merely adapting the prevalent price leadership strategy.

  6. Text-Based On-Line Conferencing: A Conceptual and Empirical Analysis Using a Minimal Prototype.

    Science.gov (United States)

    McCarthy, John C.; And Others

    1993-01-01

    Analyzes requirements for text-based online conferencing through the use of a minimal prototype. Topics discussed include prototyping with a minimal system; text-based communication; the system as a message passer versus the system as a shared data structure; and three exercises that showed how users worked with the prototype. (Contains 61…

  7. On-line crack prognosis in attachment lug using Lamb wave-deterministic resampling particle filter-based method

    Science.gov (United States)

    Yuan, Shenfang; Chen, Jian; Yang, Weibo; Qiu, Lei

    2017-08-01

    Fatigue crack growth prognosis is important for prolonging service time, improving safety, and reducing maintenance cost in many safety-critical systems, such as in aircraft, wind turbines, bridges, and nuclear plants. Combining fatigue crack growth models with the particle filter (PF) method has proved promising to deal with the uncertainties during fatigue crack growth and reach a more accurate prognosis. However, research on prognosis methods integrating on-line crack monitoring with the PF method is still lacking, as well as experimental verifications. Besides, the PF methods adopted so far are almost all sequential importance resampling-based PFs, which usually encounter sample impoverishment problems, and hence performs poorly. To solve these problems, in this paper, the piezoelectric transducers (PZTs)-based active Lamb wave method is adopted for on-line crack monitoring. The deterministic resampling PF (DRPF) is proposed to be used in fatigue crack growth prognosis, which can overcome the sample impoverishment problem. The proposed method is verified through fatigue tests of attachment lugs, which are a kind of important joint component in aerospace systems.

  8. [Research on On-Line Calibration Based Photoacoustic Spectrometry System for Monitoring the Concentration of CO2 in Atmosphere].

    Science.gov (United States)

    Zhang, Jian-feng; Pan, Sun-qiang; Lin, Xiao-lu; Hu, Peng-bing; Chen, Zhe-min

    2016-01-01

    Resonate frequency and cell constant of photoacoustic spectrum system are usually calibrated by using standard gas in laboratory, whereas the resonate frequency and cell constant will be changed in-situ, leading to measurement accuracy errors, caused by uncertainties of standard gas, differences between standard and measured gas components and changes in environmental condition, such as temperature and humidity. As to overcome the above problems, we have proposed an on-line atmospheric oxygen-based calibration technology for photoacoustic spectrum system and used in measurement of concentration of carbon dioxide in atmosphere. As the concentration of atmospheric oxygen is kept as constant as 20.96%, the on-line calibration for the photoacoustic spectrum system can be realized by detecting the swept-frequency and peak signal at 763.73 nm. The cell of the PAS has a cavity with length of 100 mm and an inner diameter of 6 mm, and worked in a first longitudinal resonant mode. The influence of environmental temperature and humidity, gas components on the photoacoustic cell's performance has been theoretically analyzed, and meanwhile the resonant frequencies and cell constants were calibrated and acquired respectively using standard gas, indoor air and outdoor air. Compared with calibrated gas analyzer, concentration of carbon dioxide is more accurate by using the resonant frequency and cell constant calculated by oxygen in tested air, of which the relative error is less than 1%, much smaller than that calculated by the standard gas in laboratory. The innovation of this paper is that using atmospheric oxygen as photoacoustic spectrum system's calibration gas effectively reduces the error caused by using standard gas and environmental condition changes, and thus improves the on-line measuring accuracy and reliability of the photoacoustic spectrum system.

  9. An On-Line Oxygen Forecasting System for Waterless Live Transportation of Flatfish Based on Feature Clustering

    Directory of Open Access Journals (Sweden)

    Yongjun Zhang

    2017-09-01

    Full Text Available Accurate prediction of forthcoming oxygen concentration during waterless live fish transportation plays a key role in reducing the abnormal occurrence, increasing the survival rate in delivery operations, and optimizing manufacturing costs. The most effective ambient monitoring techniques that are based on the analysis of historical process data when performing forecasting operations do not fully consider current ambient influence. This is likely lead to a greater deviation in on-line oxygen level forecasting in real situations. Therefore, it is not advisable for the system to perform early warning and on-line air adjustment in delivery. In this paper, we propose a hybrid method and its implementation system that combines a gray model (GM (1, 1 with least squares support vector machines (LSSVM that can be used effectively as a forecasting model to perform early warning effectively according to the dynamic changes of oxygen in a closed system. For accurately forecasting of the oxygen level, the fuzzy C-means clustering (FCM algorithm was utilized for classification according to the flatfish’s physical features—i.e., length and weight—for more pertinent training. The performance of the gray model-particle swarm optimization-least squares support vector machines (GM-PSO-LSSVM model was compared with the traditional modeling approaches of GM (1, 1 and LSSVM by applying it to predict on-line oxygen level, and the results showed that its predictions were more accurate than those of the LSSVM and grey model. Therefore, it is a suitable and effective method for abnormal condition forecasting and timely control in the waterless live transportation of flatfish.

  10. Case-based reactive navigation: a method for on-line selection and adaptation of reactive robotic control parameters.

    Science.gov (United States)

    Ram, A; Arkin, R C; Moorman, K; Clark, R J

    1997-01-01

    We present a new line of research investigating on-line adaptive reactive control mechanisms for autonomous intelligent agents. We discuss a case-based method for dynamic selection and modification of behavior assemblages for a navigational system. The case-based reasoning module is designed as an addition to a traditional reactive control system, and provides more flexible performance in novel environments without extensive high level reasoning that would otherwise slow the system down. The method is implemented in the ACBARR (case-based reactive robotic) system and evaluated through empirical simulation of the system on several different environments, including "box canyon" environments known to be problematic for reactive control systems in general.

  11. An on-line image data base system: Managing image collections

    Science.gov (United States)

    Malchus B. Baker; Daniel P. Huebner; Peter F. Ffolliott

    2000-01-01

    Many researchers and land management personnel want photographic records of the phases of their studies or projects. Depending on the personnel and the type of project, a study can result in a few or hundreds of photographic images. A data base system allows users to query using various parameters, such as key words, dates, and project locations, and to view images...

  12. Activity-Based Costing Models for Alternative Modes of Delivering On-Line Courses

    Science.gov (United States)

    Garbett, Chris

    2011-01-01

    In recent years there has been growth in online distance learning courses. This has been prompted by; new technology such as the Internet, mobile learning, video and audio conferencing: the explosion in student numbers in Higher Education, and the need for outreach to a world wide market. Web-based distance learning is seen as a solution to…

  13. Towards on-line underwater vehicle trajectory estimation using diffusion-based observers

    DEFF Research Database (Denmark)

    Jouffroy, Jerome; Nguyen, Tu Duc

    This work extends previous work (Jouffroy and Opderbecke, 2004) on the estimation of underwater vehicle trajectories using Gyro-Doppler (body-fixed velocities) and acoustic signals (earth-fixed positions). The approach consists of diffusion-based observers processing a whole trajectory segment...

  14. Reference Sphere Positioning Measurement Based on Line-Structured Light Vision Sensor

    OpenAIRE

    2013-01-01

    The line-structured light vision sensor has been used widely in industrial vision measuring fields due to its simple structure, small volume, light weight, low cost, convenient calibration, and high accuracy of measurement. To locate the reference sphere precisely with line-structured light vision sensor, a mathematical model based on the measuring principle of line-structured light vision sensor is established in the paper. Then, the positioning measurement error is analyzed in detail. The e...

  15. Effect of tip shape on line edge roughness measurement based on atomic force microscopy

    Energy Technology Data Exchange (ETDEWEB)

    Li Ning [Shanghai Second Polytechnic University, Shanghai 201209 (China); Wang Fei; Zhao Xuezeng [School of Mechanical and Electronic Engineering, Harbin Institute of Technology, Harbin 150001 (China)

    2010-12-15

    Atomic force microscopy (AFM) is an important tool in line edge roughness (LER) measurements, where accuracy for line edge identification is influenced by the shape of the tip. In this article, the effect of tip shape on LER measurement based on AFM is studied theoretically. The formulas for calculating the distance between the measured and actual line edge of the sample are presented. The effects of the three kinds of tips with different shapes are experimentally compared for validation. Suggestions on how to reduce measuring error caused by tip shape are also given.

  16. Towards on-line underwater vehicle trajectory estimation using diffusion-based observers

    DEFF Research Database (Denmark)

    Jouffroy, Jerome; Nguyen, Tu Duc

    This work extends previous work (Jouffroy and Opderbecke, 2004) on the estimation of underwater vehicle trajectories using Gyro-Doppler (body-fixed velocities) and acoustic signals (earth-fixed positions). The approach consists of diffusion-based observers processing a whole trajectory segment...... at a time, allowing the consideration of important practical problems such as different information update rates, outages, and outliers in a very simple framework. We detail issues related to real-time applications, such as implementation and convergence. A theorem guaranteeing stability of the observer...

  17. On-line experimental results of an argon gas cell-based laser ion source (KEK Isotope Separation System)

    Science.gov (United States)

    Hirayama, Y.; Watanabe, Y. X.; Imai, N.; Ishiyama, H.; Jeong, S. C.; Jung, H. S.; Miyatake, H.; Oyaizu, M.; Kimura, S.; Mukai, M.; Kim, Y. H.; Sonoda, T.; Wada, M.; Huyse, M.; Kudryavtsev, Yu.; Van Duppen, P.

    2016-06-01

    KEK Isotope Separation System (KISS) has been developed at RIKEN to produce neutron rich isotopes with N = 126 to study the β -decay properties for application to astrophysics. The KISS is an element-selective mass-separation system which consists of an argon gas cell-based on laser ion source for atomic number selection and an ISOL mass-separation system. The argon gas cell of KISS is a key component to stop and collect the unstable nuclei produced in a multi-nucleon transfer reaction, where the isotopes of interest will be selectively ionized using laser resonance ionization. We have performed off- and on-line experiments to study the basic properties of the gas cell as well as of the KISS. We successfully extracted the laser-ionized stable 56Fe (direct implantation of a 56Fe beam into the gas cell) atoms and 198Pt (emitted from the 198Pt target by elastic scattering with a 136Xe beam) atoms from the KISS during the commissioning on-line experiments. We furthermore extracted laser-ionized unstable 199Pt atoms and confirmed that the measured half-life was in good agreement with the reported value.

  18. On-line acquisition, analysis and presentation of neurophysiological data based on a personal microcomputer system.

    Science.gov (United States)

    Stromquist, B R; Pavlides, C; Zelano, J A

    1990-12-01

    A microcomputer based system is described for the acquisition, averaging, displaying, analysis and storage of electrophysiological (EPSP and post-stimulus histogram) data. The system consists of commercially available hardware (IBM-PC AT compatible, 80286 or 80386 based microcomputer, Burr-Brown analog-to-digital (A/D) converter), a custom built interface module, and a combination of commercially available and custom built software packages. The software operates within a Microsoft Windows environment and is comprised of custom built data acquisition and review modules which are linked to Microsoft's Excel program. The system is capable of four channel A/D conversion of EPSP's at a sampling frequency of up to 10 KHz (50 KHz single channel), the averaging of data including the addition and subtraction of various channels, the graphical display of data, the extraction of various data parameters, and the transfer of data to an Excel spreadsheet. The spreadsheet allows for the development of mathematical formulas for statistical analysis of data and presentation of the results in graphical form. Finally, data can easily be output to a laser printer or plotter. A sample experiment, illustrating system operation, is presented.

  19. Registration of Urban Aerial Image and LiDAR Based on Line Vectors

    Directory of Open Access Journals (Sweden)

    Qinghong Sheng

    2017-09-01

    Full Text Available In a traditional registration of a single aerial image with airborne light detection and ranging (LiDAR data using linear features that regard line direction as a control or linear features as constraints in the solution, lacking the constraint of linear position leads to the error propagation of the adjustment model. To solve this problem, this paper presents a line vector-based registration mode (LVR in which image rays and LiDAR lines are expressed by a line vector that integrates the line direction and the line position. A registration equation of line vector is set up by coplanar imaging rays and corresponding control lines. Three types of datasets consisting of synthetic, theInternational Society for Photogrammetry and Remote Sensing (ISPRS test project, and real aerial data are used. A group of progressive experiments is undertaken to evaluate the robustness of the LVR. Experimental results demonstrate that the integrated line direction and the line position contributes a great deal to the theoretical and real accuracies of the unknowns, as well as the stability of the adjustment model. This paper provides a new suggestion that, for a single image and LiDAR data, registration in urban areas can be accomplished by accommodating rich line features.

  20. On-line core monitoring system based on buckling corrected modified one group model

    Energy Technology Data Exchange (ETDEWEB)

    Freire, Fernando S., E-mail: freire@eletronuclear.gov.br [ELETROBRAS Eletronuclear Gerencia de Combustivel Nuclear, Rio de Janeiro, RJ (Brazil)

    2011-07-01

    Nuclear power reactors require core monitoring during plant operation. To provide safe, clean and reliable core continuously evaluate core conditions. Currently, the reactor core monitoring process is carried out by nuclear code systems that together with data from plant instrumentation, such as, thermocouples, ex-core detectors and fixed or moveable In-core detectors, can easily predict and monitor a variety of plant conditions. Typically, the standard nodal methods can be found on the heart of such nuclear monitoring code systems. However, standard nodal methods require large computer running times when compared with standards course-mesh finite difference schemes. Unfortunately, classic finite-difference models require a fine mesh reactor core representation. To override this unlikely model characteristic we can usually use the classic modified one group model to take some account for the main core neutronic behavior. In this model a course-mesh core representation can be easily evaluated with a crude treatment of thermal neutrons leakage. In this work, an improvement made on classic modified one group model based on a buckling thermal correction was used to obtain a fast, accurate and reliable core monitoring system methodology for future applications, providing a powerful tool for core monitoring process. (author)

  1. Reference Sphere Positioning Measurement Based on Line-Structured Light Vision Sensor

    Directory of Open Access Journals (Sweden)

    Bin Wu

    2013-01-01

    Full Text Available The line-structured light vision sensor has been used widely in industrial vision measuring fields due to its simple structure, small volume, light weight, low cost, convenient calibration, and high accuracy of measurement. To locate the reference sphere precisely with line-structured light vision sensor, a mathematical model based on the measuring principle of line-structured light vision sensor is established in the paper. Then, the positioning measurement error is analyzed in detail. The experimental results show that the method is valid and correct. In addition, an accurate measurement area which is from R0 × sin 45° to R0 × sin 75° away from the center of reference sphere is delimited through the statistical analysis of the experimental data. For the robot temperature compensation and calibration of flexible vision measurement system, this method effectively solves the positioning measurement problems about reference sphere with line-structured light vision sensor and has been applied in the industrial flexible online measurement systems successfully.

  2. Characterization of a new generation of computed radiography system based on line scanning and phosphor needles

    Science.gov (United States)

    Dragusin, Octavian; Rogge, Frank; Pauwels, Herman; Marchal, Guy; Bosmans, Hilde

    2006-03-01

    A new generation CR system that is based on phosphor needles and that uses a digitizer with line scan technology was compared to a clinically used CR system. Purely technical and more clinically related tests were run on both systems. This included the calculation of the DQE, signal-to-noise and contrast to noise ratios from Aluminum inserts, contrast detail analysis with the CDRAD phantom and the use of anthropomorphic phantoms (wrist, chest and skull) with scoring by a radiologist. X-ray exposures with various dose levels and 50kV, 70kV and 125kV were acquired. For detector doses above 0.8 μGy, all noise related measurements showed the superiority of the new technology. The MTF confirmed the improvement in sharpness: between 1 and 3 lp/mm increases ranged from 20 to 50%. Further work should be devoted to the determination of the required dose levels in the plate for the different radiological applications.

  3. On-line Optimization-Based Simulators for Fractured and Non-fractured Reservoirs

    Energy Technology Data Exchange (ETDEWEB)

    Milind D. Deo

    2005-08-31

    Oil field development is a multi-million dollar business. Reservoir simulation is often used to guide the field management and development process. Reservoir characterization and geologic modeling tools have become increasingly sophisticated. As a result the geologic models produced are complex. Most reservoirs are fractured to a certain extent. The new geologic characterization methods are making it possible to map features such as faults and fractures, field-wide. Significant progress has been made in being able to predict properties of the faults and of the fractured zones. Traditionally, finite difference methods have been employed in discretizing the domains created by geologic means. For complex geometries, finite-element methods of discretization may be more suitable. Since reservoir simulation is a mature science, some of the advances in numerical methods (linear, nonlinear solvers and parallel computing) have not been fully realized in the implementation of most of the simulators. The purpose of this project was to address some of these issues. {sm_bullet} One of the goals of this project was to develop a series of finite-element simulators to handle problems of complex geometry, including systems containing faults and fractures. {sm_bullet} The idea was to incorporate the most modern computing tools; use of modular object-oriented computer languages, the most sophisticated linear and nonlinear solvers, parallel computing methods and good visualization tools. {sm_bullet} One of the tasks of the project was also to demonstrate the construction of fractures and faults in a reservoir using the available data and to assign properties to these features. {sm_bullet} Once the reservoir model is in place, it is desirable to find the operating conditions, which would provide the best reservoir performance. This can be accomplished by utilization optimization tools and coupling them with reservoir simulation. Optimization-based reservoir simulation was one of the

  4. A standard database for drug repositioning

    Science.gov (United States)

    Brown, Adam S.; Patel, Chirag J.

    2017-01-01

    Drug repositioning, the process of discovering, validating, and marketing previously approved drugs for new indications, is of growing interest to academia and industry due to reduced time and costs associated with repositioned drugs. Computational methods for repositioning are appealing because they putatively nominate the most promising candidate drugs for a given indication. Comparing the wide array of computational repositioning methods, however, is a challenge due to inconsistencies in method validation in the field. Furthermore, a common simplifying assumption, that all novel predictions are false, is intellectually unsatisfying and hinders reproducibility. We address this assumption by providing a gold standard database, repoDB, that consists of both true positives (approved drugs), and true negatives (failed drugs). We have made the full database and all code used to prepare it publicly available, and have developed a web application that allows users to browse subsets of the data (http://apps.chiragjpgroup.org/repoDB/). PMID:28291243

  5. Competencies and materials for repositioning cataloguers for ...

    African Journals Online (AJOL)

    Competencies and materials for repositioning cataloguers for information management ... AFRICAN JOURNALS ONLINE (AJOL) · Journals · Advanced Search ... The purpose of this study was to determine the competencies and materials for ...

  6. Automated Planning for Liner Shipping Fleet Repositioning

    DEFF Research Database (Denmark)

    Tierney, Kevin; Jensen, Rune Møller; Kroer, Christian

    2012-01-01

    The Liner Shipping Fleet Repositioning Problem (LSFRP) poses a large financial burden on liner shipping firms. During repositioning, vessels are moved between services in a liner shipping network. The LSFRP is characterized by chains of interacting activities, many of which have costs that are a ......The Liner Shipping Fleet Repositioning Problem (LSFRP) poses a large financial burden on liner shipping firms. During repositioning, vessels are moved between services in a liner shipping network. The LSFRP is characterized by chains of interacting activities, many of which have costs......-integer program (MIP) and a novel method called Temporal Optimization Planning (TOP). We evaluate the performance of each of these techniques on a dataset of real-world instances from our industrial collaborator, and show that automated planning scales to the size of problems faced by industry....

  7. Temporal Optimization Planning for Fleet Repositioning

    DEFF Research Database (Denmark)

    Tierney, Kevin; Jensen, Rune Møller

    2011-01-01

    Fleet repositioning problems pose a high financial bur- den on shipping firms, but have received little attention in the literature, despite their high importance to the shipping industry. Fleet repositioning problems are characterized by chains of interacting activities, but state-of-the-art pla......Fleet repositioning problems pose a high financial bur- den on shipping firms, but have received little attention in the literature, despite their high importance to the shipping industry. Fleet repositioning problems are characterized by chains of interacting activities, but state......-of-the-art planning and scheduling techniques do not offer cost models that are rich enough to represent essential objectives of these problems. To this end, we introduce a novel framework called Temporal Optimization Planning (TOP). TOP uses partial order planning to build optimization models associated...

  8. Analysis of a Kalman filter based method for on-line estimation of atmospheric dispersion parameters using radiation monitoring data

    DEFF Research Database (Denmark)

    Drews, Martin; Lauritzen, Bent; Madsen, Henrik

    2005-01-01

    A Kalman filter method is discussed for on-line estimation of radioactive release and atmospheric dispersion from a time series of off-site radiation monitoring data. The method is based on a state space approach, where a stochastic system equation describes the dynamics of the plume model...... parameters, and the observables are linked to the state variables through a static measurement equation. The method is analysed for three simple state space models using experimental data obtained at a nuclear research reactor. Compared to direct measurements of the atmospheric dispersion, the Kalman filter...... estimates are found to agree well with the measured parameters, provided that the radiation measurements are spread out in the cross-wind direction. For less optimal detector placement it proves difficult to distinguish variations in the source term and plume height; yet the Kalman filter yields consistent...

  9. On-line surveillance of a dynamic process by a moving system based on pulsed digital holographic interferometry.

    Science.gov (United States)

    Pedrini, Giancarlo; Alexeenko, Igor; Osten, Wolfgang; Schnars, Ulf

    2006-02-10

    A method based on pulsed digital holographic interferometry for the measurement of dynamic deformations of a surface by using a moving system is presented. The measuring system may move with a speed of several meters per minute and can measure deformation of the surface with an accuracy of better than 50 nm. The deformation is obtained by comparison of the wavefronts recorded at different times with different laser pulses produced by a Nd:YAG laser. The effect due to the movement of the measuring system is compensated for by digital processing of the different holograms. The system is well suited for on-line surveillance of a dynamic process such as laser welding and friction stir welding. Experimental results are presented, and the advantages of the method are discussed.

  10. On-line equalization for lithium-ion battery packs based on charging cell voltages: Part 1. Equalization based on remaining charging capacity estimation

    Science.gov (United States)

    Zheng, Yuejiu; Ouyang, Minggao; Lu, Languang; Li, Jianqiu; Han, Xuebing; Xu, Liangfei

    2014-02-01

    Because of the inevitable inconsistency during manufacture and use of battery cells, cell variations in battery packs have significant impacts on battery pack capacities, durability and safety for electric vehicles (EVs). To reduce cell variations and increase pack capacity, cell equalization is essentially required. In the series of two papers, we discover that dissipative cell equalization (DCE) using dissipative resistances is a feasible on-line equalization method for battery packs in EVs. We subsequently propose on-line equalization algorithms for lithium-ion battery packs based on charging cell voltage curves (CCVCs). The objective of these algorithms is to maximize pack capacities by conditioning CCVCs. As the first paper of the series, we first briefly review equalization topologies and algorithms. We discover cell remaining charging capacity (RCC) can be on-line estimated and further propose DCE algorithm based on remaining charging capacity estimation (RCCE). We establish a pack model with 8 cells in series and simulate 4 scenes with different cell variations. RCCE-DCE algorithm is proved to be effective by comparing pack capacities with/without RCCE-DCE algorithm. The equalization capability and over-equalization prevention are further examined, and the result shows that RCCE-DCE algorithm is suitable for on-line equalization in EVs.

  11. On-line experimental validation of a model-based diagnostic algorithm dedicated to a solid oxide fuel cell system

    Science.gov (United States)

    Polverino, Pierpaolo; Esposito, Angelo; Pianese, Cesare; Ludwig, Bastian; Iwanschitz, Boris; Mai, Andreas

    2016-02-01

    In the current energetic scenario, Solid Oxide Fuel Cells (SOFCs) exhibit appealing features which make them suitable for environmental-friendly power production, especially for stationary applications. An example is represented by micro-combined heat and power (μ-CHP) generation units based on SOFC stacks, which are able to produce electric and thermal power with high efficiency and low pollutant and greenhouse gases emissions. However, the main limitations to their diffusion into the mass market consist in high maintenance and production costs and short lifetime. To improve these aspects, the current research activity focuses on the development of robust and generalizable diagnostic techniques, aimed at detecting and isolating faults within the entire system (i.e. SOFC stack and balance of plant). Coupled with appropriate recovery strategies, diagnosis can prevent undesired system shutdowns during faulty conditions, with consequent lifetime increase and maintenance costs reduction. This paper deals with the on-line experimental validation of a model-based diagnostic algorithm applied to a pre-commercial SOFC system. The proposed algorithm exploits a Fault Signature Matrix based on a Fault Tree Analysis and improved through fault simulations. The algorithm is characterized on the considered system and it is validated by means of experimental induction of faulty states in controlled conditions.

  12. Broadband network on-line data acquisition system with web based interface for control and basic analysis

    Science.gov (United States)

    Polkowski, Marcin; Grad, Marek

    2016-04-01

    Passive seismic experiment "13BB Star" is operated since mid 2013 in northern Poland and consists of 13 broadband seismic stations. One of the elements of this experiment is dedicated on-line data acquisition system comprised of both client (station) side and server side modules with web based interface that allows monitoring of network status and provides tools for preliminary data analysis. Station side is controlled by ARM Linux board that is programmed to maintain 3G/EDGE internet connection, receive data from digitizer, send data do central server among with additional auxiliary parameters like temperatures, voltages and electric current measurements. Station side is controlled by set of easy to install PHP scripts. Data is transmitted securely over SSH protocol to central server. Central server is a dedicated Linux based machine. Its duty is receiving and processing all data from all stations including auxiliary parameters. Server side software is written in PHP and Python. Additionally, it allows remote station configuration and provides web based interface for user friendly interaction. All collected data can be displayed for each day and station. It also allows manual creation of event oriented plots with different filtering abilities and provides numerous status and statistic information. Our solution is very flexible and easy to modify. In this presentation we would like to share our solution and experience. National Science Centre Poland provided financial support for this work via NCN grant DEC-2011/02/A/ST10/00284.

  13. Nucleosome repositioning underlies dynamic gene expression.

    Science.gov (United States)

    Nocetti, Nicolas; Whitehouse, Iestyn

    2016-03-15

    Nucleosome repositioning at gene promoters is a fundamental aspect of the regulation of gene expression. However, the extent to which nucleosome repositioning is used within eukaryotic genomes is poorly understood. Here we report a comprehensive analysis of nucleosome positions as budding yeast transit through an ultradian cycle in which expression of >50% of all genes is highly synchronized. We present evidence of extensive nucleosome repositioning at thousands of gene promoters as genes are activated and repressed. During activation, nucleosomes are relocated to allow sites of general transcription factor binding and transcription initiation to become accessible. The extent of nucleosome shifting is closely related to the dynamic range of gene transcription and generally related to DNA sequence properties and use of the coactivators TFIID or SAGA. However, dynamic gene expression is not limited to SAGA-regulated promoters and is an inherent feature of most genes. While nucleosome repositioning occurs pervasively, we found that a class of genes required for growth experience acute nucleosome shifting as cells enter the cell cycle. Significantly, our data identify that the ATP-dependent chromatin-remodeling enzyme Snf2 plays a fundamental role in nucleosome repositioning and the expression of growth genes. We also reveal that nucleosome organization changes extensively in concert with phases of the cell cycle, with large, regularly spaced nucleosome arrays being established in mitosis. Collectively, our data and analysis provide a framework for understanding nucleosome dynamics in relation to fundamental DNA-dependent transactions.

  14. Formación on line On line learning

    Directory of Open Access Journals (Sweden)

    O. Grau-Perejoan

    2008-09-01

    Full Text Available La formación on line es una modalidad de enseñanza a distancia basada en las nuevas tecnologías. En este artículo se pretende hacer una introducción a base de describir a grandes rasgos sus características principales: asincronía, no presencialidad, comunicación escrita, función del profesor on line, así como los retos, los riesgos, las ventajas y los inconvenientes que plantea. Se exponen las diferencias entre la formación on line y la formación presencial, de manera que los docentes puedan adaptar de la mejor manera posible sus propuestas formativas a la modalidad on line. Se introduce el importantísimo papel de la planificación y de la fase de diseño y, finalmente, se repasan conceptos útiles para comprender mejor el mundo de la formación on line como son los conceptos entorno virtual de aprendizaje (EVA o Blended Learning (B-Learning.On line learning is a type of distance education based on new technologies. This article's aim is to introduce its main characteristics -asynchrony, non-presentiality, written communication, e-teacher role- as well as its challenges, risks, advantages and limitations. Differences between on line learning and face-to-face learning are presented in order to enable educational professionals to adapt their courses to the on line methodology. Planning and designing are introduced as key phases and, finally, useful concepts such as Virtual Learning Environment (VLE or Blended Learning (B-Learning are reviewed in order to achieve a better understanding of the on line learning field.

  15. Operative correction of judoists’ training loads on the base of on-line monitoring of heart beats rate

    Directory of Open Access Journals (Sweden)

    Liu Yong Qiang

    2015-02-01

    Full Text Available Purpose: ensure increase of effectiveness of training process’s control by means of operative correction of training loads of different qualification judo wrestlers’ heart beats rate indicators. Material: the research was conducted on the base of Brest SCJSOR № 1. Judo wrestlers of different sport qualification (age 17-19 years old, n=15 participated in the research. Monitoring of judo wrestlers’ heart beats rate was carried out with the help of system “Polar”. Results: we have found factorial structure of functional fitness in every profile of sportsmen. Model characteristics of judo wrestlers were supplemented with the most important sides of functional fitness. Analysis of indicators of restoration effectiveness indicators (REI in both groups of judo wrestlers showed high level of organism’s responsiveness to training load of special and power orientation in comparison with speed power load. We have worked out algorithm of operative correction of training loads by indicators of heart beats rate in training process, depending on orientation and intensity of loads’ physiological influence on judo wrestler. Conclusions: Telemetric on-line monitoring of sportsman’s heart beats rate and calculation of REI permit to objectively assess effectiveness of training’s construction and of micro-cycle in total and detect in due time the trend to development of over-loading and failure of adaptation.

  16. Experiences with non-intrusive monitoring of distribution transformers based on the on-line frequency response

    Directory of Open Access Journals (Sweden)

    E. Gomez Luna

    2015-04-01

    Full Text Available The following article presents the results obtained in experiences that use the Impulse Frequency Response Analysis (IFRA method with a transformer in service. The IFRA method has been implemented in order to transform the transient signals to the frequency domain using Discrete Fourier Transform (DFT. However, it can be considered that the DFT is not the most suitable tool for this type of analysis, since, by definition, this tool is useful for processing stationary signals. Taking that into consideration, the analysis of transient signals could be hypothetically improved by using continuous wavelet transform (CWT, given their variable time/frequency resolution. The analysis of transient signals in Wavelet domain has improved the repeatability of the frequency response curves, as it has been observed in experimental results. The proposed on-line IFRA method, based on Wavelet transform, was validated under load and no-load conditions on a 150 kVA three-phase transformer 13200/225 Volts, in the Campus of the Universidad del Valle, Cali, Colombia.

  17. SU-E-J-92: On-Line Cone Beam CT Based Planning for Emergency and Palliative Radiation Therapy

    Energy Technology Data Exchange (ETDEWEB)

    Held, M; Morin, O; Pouliot, J [UC San Francisco, San Francisco, CA (United States)

    2014-06-01

    Purpose: To evaluate and develop the feasibility of on-line cone beam CT based planning for emergency and palliative radiotherapy treatments. Methods: Subsequent to phantom studies, a case library of 28 clinical megavoltage cone beam CT (MVCBCT) was built to assess dose-planning accuracies on MVCBCT for all anatomical sites. A simple emergency treatment plan was created on the MVCBCT and copied to its reference CT. The agreement between the dose distributions of each image pair was evaluated by the mean dose difference of the dose volume and the gamma index of the central 2D axial plane. An array of popular urgent and palliative cases was also evaluated for imaging component clearance and field-of-view. Results: The treatment cases were categorized into four groups (head and neck, thorax/spine, pelvis and extremities). Dose distributions for head and neck treatments were predicted accurately in all cases with a gamma index of >95% for 2% and 2 mm criteria. Thoracic spine treatments had a gamma index as low as 60% indicating a need for better uniformity correction and tissue density calibration. Small anatomy changes between CT and MVCBCT could contribute to local errors. Pelvis and sacral spine treatment cases had a gamma index between 90% and 98% for 3%/3 mm criteria. The limited FOV became an issue for large pelvis patients. Imaging clearance was difficult for cases where the tumor was positioned far off midline. Conclusion: The MVCBCT based dose planning and delivery approach is feasible in many treatment cases. Dose distributions for head and neck patients are unrestrictedly predictable. Some FOV restrictions apply to other treatment sites. Lung tissue is most challenging for accurate dose calculations given the current imaging filters and corrections. Additional clinical cases for extremities need to be included in the study to assess the full range of site-specific planning accuracies. This work is supported by Siemens.

  18. On-line randomized controlled trial of an internet based psychologically enhanced intervention for people with hazardous alcohol consumption.

    Directory of Open Access Journals (Sweden)

    Paul Wallace

    Full Text Available BACKGROUND: Interventions delivered via the Internet have the potential to address the problem of hazardous alcohol consumption at minimal incremental cost, with potentially major public health implications. It was hypothesised that providing access to a psychologically enhanced website would result in greater reductions in drinking and related problems than giving access to a typical alcohol website simply providing information on potential harms of alcohol. DYD-RCT Trial registration: ISRCTN 31070347. METHODOLOGY/PRINCIPAL FINDINGS: A two-arm randomised controlled trial was conducted entirely on-line through the Down Your Drink (DYD website. A total of 7935 individuals who screened positive for hazardous alcohol consumption were recruited and randomized. At entry to the trial, the geometric mean reported past week alcohol consumption was 46.0 (SD 31.2 units. Consumption levels reduced substantially in both groups at the principal 3 month assessment point to an average of 26.0 (SD 22.3 units. Similar changes were reported at 1 month and 12 months. There were no significant differences between the groups for either alcohol consumption at 3 months (intervention: control ratio of geometric means 1.03, 95% CI 0.97 to 1.10 or for this outcome and the main secondary outcomes at any of the assessments. The results were not materially changed following imputation of missing values, nor was there any evidence that the impact of the intervention varied with baseline measures or level of exposure to the intervention. CONCLUSIONS/SIGNIFICANCE: Findings did not provide support for the hypothesis that access to a psychologically enhanced website confers additional benefit over standard practice and indicate the need for further research to optimise the effectiveness of Internet-based behavioural interventions. The trial demonstrates a widespread and potentially sustainable demand for Internet based interventions for people with hazardous alcohol consumption

  19. A new lithium-ion battery internal temperature on-line estimate method based on electrochemical impedance spectroscopy measurement

    Science.gov (United States)

    Zhu, J. G.; Sun, Z. C.; Wei, X. Z.; Dai, H. F.

    2015-01-01

    The power battery thermal management problem in EV (electric vehicle) and HEV (hybrid electric vehicle) has been widely discussed, and EIS (electrochemical impedance spectroscopy) is an effective experimental method to test and estimate the status of the battery. Firstly, an electrochemical-based impedance matrix analysis for lithium-ion battery is developed to describe the impedance response of electrochemical impedance spectroscopy. Then a method, based on electrochemical impedance spectroscopy measurement, has been proposed to estimate the internal temperature of power lithium-ion battery by analyzing the phase shift and magnitude of impedance at different ambient temperatures. Respectively, the SoC (state of charge) and temperature have different effects on the impedance characteristics of battery at various frequency ranges in the electrochemical impedance spectroscopy experimental study. Also the impedance spectrum affected by SoH (state of health) is discussed in the paper preliminary. Therefore, the excitation frequency selected to estimate the inner temperature is in the frequency range which is significantly influenced by temperature without the SoC and SoH. The intrinsic relationship between the phase shift and temperature is established under the chosen excitation frequency. And the magnitude of impedance related to temperature is studied in the paper. In practical applications, through obtaining the phase shift and magnitude of impedance, the inner temperature estimation could be achieved. Then the verification experiments are conduced to validate the estimate method. Finally, an estimate strategy and an on-line estimation system implementation scheme utilizing battery management system are presented to describe the engineering value.

  20. Metrological Characterization of an Improved DSP-Based On-line Integrator for Magnetic Measurements at CERN

    CERN Document Server

    Arpaia, P; Spiezia, G

    2007-01-01

    An improved on-line version of the self-calibrating digital instrument for flux measurements on superconductive magnets for particle accelerators, prototyped at the European Organization for Nuclear Research (CERN) in cooperation with the University of Sannio, is proposed. The instrument acquires voltage arising from rotating coils transducers. Then, the samples are online integrated and suitably processed in order to achieve flux analysis time down to 2.0 ìs, with resolution of 50 ns. Details about hardware and firmware conception, on-line measurement principle, and preliminary results of metrological characterization of the prototype are provided.

  1. Repositioning chairs in benign paroxysmal positional vertigo

    DEFF Research Database (Denmark)

    West, Niels; Hansen, Søren; Møller, Martin Nue

    2016-01-01

    The objective was to evaluate the clinical value of repositioning chairs in management of refractory benign paroxysmal positional vertigo (BPPV) and to study how different BPPV subtypes respond to treatment. We performed a retrospective chart review of 150 consecutive cases with refractory vertigo...

  2. On-line Chip based 2D RP/RP LC-MS/MS Method for Proteomic Analysis

    Science.gov (United States)

    Hunter, Christie; Albanese, Jenny; van Soest, Remco; Zhu, Xiang

    2013-01-01

    Two-dimensional (2D) liquid chromatography is widely used for proteome identification and quantification using the advantage of increasing peak capacity. Herein, we developed an simplified chip based 2D-LC workflow using a high pH/RP first dimensional separation and low pH/RP secondary dimension coupled to mass spectrometer for proteomic analysis. The 2D LC separation was performed using ekspert™ nanoLC 425(Eksigent, part of AB SCIEX) system. Digested E. coli cell lysates were first loaded onto a 200μm × 15cm C18 column at pH 9.8 with a flowrate of 1 μL/min. Step gradient was used to sequentially elute peptide fractions, which were diluted to pH 2.5 before being captured by a 200μm × 6mm C18 chip trap column. Each fraction was then separated with a 75 μm × 15cm C18 chip column at 300 nL/min and analyzed with TripleTOF® 5600 (AB SCIEX). Data was processed with ProteinPilot™ Software (AB SCIEX). The preliminary result suggested the on-line 2D RP-RP method as an easy and competitive approach for proteome discovery. The comparison experiments of 1D, 2D-6 fraction and 2D-10 fraction were performed. Using ∼1ug of E. coli digested cell lysates, there are 1.8× and 2.1× increase in the identification numbers for 2D-6 and 2D-10 fractions versus the 1D configuration at the peptide level (5% local FDR). The other advantage of 2D workflow is the larger sample loading capacities on the column. When the loading amount was increased by 10×, the number of detected peptides increased by 3.3× and 4× for the 2D 6 and 10 fraction workflows, respectively, over 1D workflow. The measured retention time of peptides detected in both the 1D 1ug and 2D 10ug experiments showed very good correlation (r2 0.99, slope 1.0). Further optimization of both the first and second dimension is ongoing to further improve the peptide detection rates.

  3. On-line depth measurement for laser-drilled holes based on the intensity of plasma emission

    Science.gov (United States)

    Ho, Chao-Ching; Chiu, Chih-Mu; Chang, Yuan-Jen; Hsu, Jin-Chen; Kuo, Chia-Lung

    2014-09-01

    The direct time-resolved depth measurement of blind holes is extremely difficult due to the short time interval and the limited space inside the hole. This work presents a method that involves on-line plasma emission acquisition and analysis to obtain correlations between the machining processes and the optical signal output. Given that the depths of laser-machined holes can be estimated on-line using a coaxial photodiode, this was employed in our inspection system. Our experiments were conducted in air under normal atmospheric conditions without gas assist. The intensity of radiation emitted from the vaporized material was found to correlate with the depth of the hole. The results indicate that the estimated depths of the laser-drilled holes were inversely proportional to the maximum plasma light emission measured for a given laser pulse number.

  4. Markov Decision Process Based Energy-Efficient On-Line Scheduling for Slice-Parallel Video Decoders on Multicore Systems

    CERN Document Server

    Mastronarde, Nicholas; Atienza, David; Frossard, Pascal; van der Schaar, Mihaela

    2011-01-01

    We consider the problem of energy-efficient on-line scheduling for slice-parallel video decoders on multicore systems. We assume that each of the processors are Dynamic Voltage Frequency Scaling (DVFS) enabled such that they can independently trade off performance for power, while taking the video decoding workload into account. In the past, scheduling and DVFS policies in multi-core systems have been formulated heuristically due to the inherent complexity of the on-line multicore scheduling problem. The key contribution of this report is that we rigorously formulate the problem as a Markov decision process (MDP), which simultaneously takes into account the on-line scheduling and per-core DVFS capabilities; the separate power consumption of the processor cores and caches; and the loss tolerant and dynamic nature of the video decoder's traffic. In particular, we model the video traffic using a Direct Acyclic Graph (DAG) to capture the precedence constraints among frames in a Group of Pictures (GOP) structure, ...

  5. Repositioning news and public connection in everyday life

    DEFF Research Database (Denmark)

    Swart, Joëlle; Peters, Chris; Broersma, Marcel

    2016-01-01

    academic discussions surrounding these shifts are often explored in terms of normative ideals ascribed to political systems or civic cultures, we propose to reposition the debate by departing from the practices and preferences of the news user instead. Therefore, we deconstruct and translate the concept...... of public connection into four dimensions that emphasize people’s lived experiences: inclusiveness, engagement, relevance, and constructiveness. Situating these in an everyday life framework, this article advances a user-based perspective that considers the role of news for people in digital societies...

  6. Maxillary repositioning according to Frankfort horizontal plane during orthognathic surgery

    Directory of Open Access Journals (Sweden)

    Mehdi Ghoreishian

    2013-01-01

    Full Text Available Context: There are a lot of disagreements among surgeons over controlling the maxillary position during orthognathic surgery. Aim: To investigate maxillary repositioning according to Frankfort horizontal plane in orthognathic surgery. Materials and Methods: Fourteen patients were selected who were submitted to maxillary or bimaxillary surgery. Maxillary model surgery was performed based on the treatment planning and an intermediate splint was made. The surgical technique in this study was based on maxillary osteotomy according to the findings of the model surgery, in a manner that the osteotomy line was parallel to the Frankfort horizontal plane. Intermediate splint was used for repositioning of the maxilla in the new position and the vertical position of that was determined according to external reference point and fixed on this position. The upper central incisor designed from prediction tracing and post-operative cephalometry on the first tracing. The new position of maxilla was evaluated horizontally and vertically. Statistical Analysis Used: A paired t-test was used to compare the predicted maxillary position and the actual position. Association between these two groups of variables was evaluated with Pearson correlation. Results: The mean difference between the maxillary planned position and post-operative cephalometric radiography varied between 0.3 mm and 0.9 mm vertically (P value = 0.315 and 0.0 mm and 0.9 mm horizontally (P value = 0.034. The averages of horizontally and vertically observed changes were 0.3 mm and 0.17 mm respectively (P < 0.001. Conclusion: Good surgical accuracy in repositioning of the maxilla can be achieved according to Frankfort horizontal plane during the surgery. By eliminating the ramping effect the accuracy of surgery increases.

  7. Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer

    Directory of Open Access Journals (Sweden)

    Kouji Banno

    2015-01-01

    Full Text Available The goals of drug repositioning are to find a new pharmacological effect of a drug for which human safety and pharmacokinetics are established and to expand the therapeutic range of the drug to another disease. Such drug discovery can be performed at low cost and in the short term based on the results of previous clinical trials. New drugs for gynecologic tumors may be found by drug repositioning. For example, PPAR ligands may be effective against ovarian cancer, since PPAR activation eliminates COX-2 expression, arrests the cell cycle, and induces apoptosis. Metformin, an antidiabetic drug, is effective for endometrial cancer through inhibition of the PI3K-Akt-mTOR pathway by activating LKB1-AMPK and reduction of insulin and insulin-like growth factor-1 due to AMPK activation. COX-2 inhibitors for cervical cancer may also be examples of drug repositioning. PGE2 is induced in the arachidonate cascade by COX-2. PGE2 maintains high expression of COX-2 and induces angiogenic factors including VEGF and bFGF, causing carcinogenesis. COX-2 inhibitors suppress these actions and inhibit carcinogenesis. Combination therapy using drugs found by drug repositioning and current anticancer drugs may increase efficacy and reduce adverse drug reactions. Thus, drug repositioning may become a key approach for gynecologic cancer in drug discovery.

  8. From Teacher-in-Role to Researcher-in-Role: Possibilities for Repositioning Children through Role-Based Strategies in Classroom Research

    Science.gov (United States)

    Aitken, V.

    2014-01-01

    This article describes the drama-based research strategy "researcher-in-role," developed during the two-year "Connecting Curriculum, Connecting Learning" project, based in New Zealand. First, a definition of researcher-in-role is offered along with a survey of relevant literature. Then the evolution and implementation of the…

  9. On-line determination of sludge settling velocity for flux-based real-time control of secondary clarifiers.

    Science.gov (United States)

    Lynggaard-Jensen, A; Lading, L

    2006-01-01

    The state diagram for operation of secondary clarifiers is used to design a control algorithm for the return sludge pumping and determination of the actual hydraulic capacity of the biological step of a wastewater treatment plant. On-line input for the control algorithm is derived from a sludge volume sensor and a suspended solids sensor in the form of software sensors giving values for the sludge settling characteristics - settling velocity, sludge volume index, initial settling velocity and the exponent in the Vesilind equation - allowing the control to accommodate the ever changing settling characteristics and thereby keep the suspended solids flux in the clarifiers in balance for both dry weather flows and during rain events. The control algorithm has been implemented, tested and set into normal operation on a full scale wastewater treatment plant.

  10. An FE Based On-line Model for the Prediction of Work Roll Thermal Profile in Hot Strip Rolling

    Science.gov (United States)

    Choi, Ji Won; Lee, Jung Hyeung; Sun, Cheng Gang; Hwang, Sang Moo

    2010-06-01

    Prediction and control of the thermal deformation of the work roll is vital for enhancing product quality in hot strip and plate rolling. In this paper, we present an on-line model for the prediction of the work roll thermal profile. The model is developed on the basis of an integrated finite element model for the coupled analysis of heat transfer and deformation occurring at the bite zone, to rigorously take into account the effect of various rolling parameters on the thermal behavior of the work roll. The validity of the model is demonstrated through comparison with measurements made in an industrial hot strip mill. Also, an emphasis is given to the examination the effect of some selected rolling parameters in an actual production environment.

  11. On line separation of overlapped signals from multi-time photons for the GEM-based detection system

    Science.gov (United States)

    Czarski, T.; Pozniak, K. T.; Chernyshova, M.; Malinowski, K.; Kasprowicz, G.; Kolasinski, P.; Krawczyk, R.; Wojenski, A.; Zabolotny, W.

    2015-09-01

    The Triple Gas Electron Multiplier (T-GEM) is presented as soft X-ray (SXR) energy and position sensitive detector for high-resolution X-ray diagnostics of magnetic confinement fusion plasmas. Multi-channel measurement system and serial data acquisition for X-ray energy and position recognition is described. Fundamental characteristics are presented for two dimensional detector structure. Typical signals of ADC - Analog to Digital Converter are considered for charge value and position estimation. Coinciding signals for high flux radiation cause the problem for cluster charge identification. The amplifier with shaper determines time characteristics and limits the pulses frequency. Separation of coincided signals was introduced and verified for simulation experiments. On line separation of overlapped signals was implemented applying the FPGA technology with relatively simple firmware procedure. Representative results for reconstruction of coinciding signals are demonstrated.

  12. An on-line calibration algorithm for external parameters of visual system based on binocular stereo cameras

    Science.gov (United States)

    Wang, Liqiang; Liu, Zhen; Zhang, Zhonghua

    2014-11-01

    Stereo vision is the key in the visual measurement, robot vision, and autonomous navigation. Before performing the system of stereo vision, it needs to calibrate the intrinsic parameters for each camera and the external parameters of the system. In engineering, the intrinsic parameters remain unchanged after calibrating cameras, and the positional relationship between the cameras could be changed because of vibration, knocks and pressures in the vicinity of the railway or motor workshops. Especially for large baselines, even minute changes in translation or rotation can affect the epipolar geometry and scene triangulation to such a degree that visual system becomes disabled. A technology including both real-time examination and on-line recalibration for the external parameters of stereo system becomes particularly important. This paper presents an on-line method for checking and recalibrating the positional relationship between stereo cameras. In epipolar geometry, the external parameters of cameras can be obtained by factorization of the fundamental matrix. Thus, it offers a method to calculate the external camera parameters without any special targets. If the intrinsic camera parameters are known, the external parameters of system can be calculated via a number of random matched points. The process is: (i) estimating the fundamental matrix via the feature point correspondences; (ii) computing the essential matrix from the fundamental matrix; (iii) obtaining the external parameters by decomposition of the essential matrix. In the step of computing the fundamental matrix, the traditional methods are sensitive to noise and cannot ensure the estimation accuracy. We consider the feature distribution situation in the actual scene images and introduce a regional weighted normalization algorithm to improve accuracy of the fundamental matrix estimation. In contrast to traditional algorithms, experiments on simulated data prove that the method improves estimation

  13. Design of a Medical Triage Evidence-Based Clinical Management Protocol and Implementation of Medical Triage On-Line Training for Use by Mission of Mercy Volunteers.

    Science.gov (United States)

    Allen, Kimberly D; DiBartolo, Mary C; Welsh, Debra L; Brown, Voncelia

    2015-01-01

    Evidence-based protocols in safety net settings can help standardize care practices, increase organizational workflow, and enhance quality outcomes for those receiving services. The purpose of this quality improvement project is two-fold: to design an evidence-based medical triage clinical management protocol, and, to influence adherence to that protocol by safety net medical triage volunteers through an on-line volunteer orientation. Leadership skills were required to help translate evidence-based practice recommendations into useful tools to assist in directing practice. Project outcomes included successful multidisciplinary practice change, significantly improved volunteer knowledge surrounding medical triage protocol parameters, increased organizational workflow, and enhanced quality client outcomes.

  14. School-Based Multidisciplinary Teacher Team-Building Combining On-Line Professional Development (ESSEA) and Field-Based Environmental Monitoring (GLOBE)

    Science.gov (United States)

    Low, R.

    2003-12-01

    The multidisciplinary nature of Earth system science provides a strong foundation for integrated science teaching at the K-12 level. In a Minneapolis-St. Paul based project, urban middle school teaching teams composed of language arts and math specialists as well as physical, Earth, and biological science teachers participate in the NASA Earth system science course (ESSEA) and in the international GLOBE environmental monitoring project. For students, the goal is to integrate science throughout the curriculum as well as involve classes from different subjects in a high-interest school science project. For teachers, the project provides greatly-needed classroom support and teacher team building, as well as professional development. The on-line course provides continuity and communication between the different team members. Face-to-face meetings with the instructors on site are conducted every 4 weeks. The problem-based learning approach to environmental issues developed in the ESSEA course lends itself to application to local environmental issues. New ESSEA modules developed for the project highlight environmental problems associated with flooding, introduced species, and eutrofication of lakes and rivers located near the participating schools. In addition, ESSEA participants are certified as GLOBE teachers, and assist their students in monitoring water quality. The synergistic partnership of ESSEA and GLOBE provides an attractive package upon which long-term school-based environmental monitoring projects can be based.

  15. Development of a video-based slurry sensor for on-line ash analysis. Eighth quarterly technical progress report, July 1, 1996--September 30, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Adel, G.T.; Luttrell, G.H.

    1996-10-22

    Automatic control of fine coal cleaning circuits has traditionally been limited by the lack of sensors for on-line ash analysis. Although several nuclear-based analyzers are available, none have seen widespread acceptance. This is largely due to the fact that nuclear sensors are expensive and tend to be influenced by changes in seam type and pyrite content. Recently, researchers at VPI&SU have developed an optical sensor for phosphate analysis. The sensor uses image processing technology to analyze video images of phosphate ore. It is currently being used by PCS Phosphate for off-fine analysis of dry flotation concentrate. The primary advantages of optical sensors over nuclear sensors are that they are significantly cheaper, are not subject to measurement variations due to changes in high atomic number minerals, are inherently safer and require no special radiation permitting. The purpose of this work is to apply the knowledge gained in the development of an optical phosphate analyzer to the development of an on-fine ash analyzer for fine coal slurries. During the past quarter, installation of the video-based ash analyzer at the Middle Fork plant site was completed. A method of measuring and automatically adjusting for small variations in the sensor illumination scheme was developed and implemented. Initial on-line testing of the ash analyzer has yielded adequate calibration information, and the sensor is currently operating on-line. The on-line performance of the sensor is under review and the information from this review will be included in the final report.

  16. Large-scale Direct Targeting for Drug Repositioning and Discovery

    Science.gov (United States)

    Zheng, Chunli; Guo, Zihu; Huang, Chao; Wu, Ziyin; Li, Yan; Chen, Xuetong; Fu, Yingxue; Ru, Jinlong; Ali Shar, Piar; Wang, Yuan; Wang, Yonghua

    2015-01-01

    A system-level identification of drug-target direct interactions is vital to drug repositioning and discovery. However, the biological means on a large scale remains challenging and expensive even nowadays. The available computational models mainly focus on predicting indirect interactions or direct interactions on a small scale. To address these problems, in this work, a novel algorithm termed weighted ensemble similarity (WES) has been developed to identify drug direct targets based on a large-scale of 98,327 drug-target relationships. WES includes: (1) identifying the key ligand structural features that are highly-related to the pharmacological properties in a framework of ensemble; (2) determining a drug’s affiliation of a target by evaluation of the overall similarity (ensemble) rather than a single ligand judgment; and (3) integrating the standardized ensemble similarities (Z score) by Bayesian network and multi-variate kernel approach to make predictions. All these lead WES to predict drug direct targets with external and experimental test accuracies of 70% and 71%, respectively. This shows that the WES method provides a potential in silico model for drug repositioning and discovery. PMID:26155766

  17. Flip-Floppers and Wafflers: Explanations and Repositioning

    DEFF Research Database (Denmark)

    Robison, Joshua

    Repositioning by political elites plays a key role in a variety of political phenomena, including legislative policymaking, and campaigning. However, the likely electoral consequences from repositioning remain unclear due to conflicting results from the empirical literature. I contribute to this ......Repositioning by political elites plays a key role in a variety of political phenomena, including legislative policymaking, and campaigning. However, the likely electoral consequences from repositioning remain unclear due to conflicting results from the empirical literature. I contribute...... implications not just for this particular element of elite behavior, but also related questions concerning governmental accountability and representation....

  18. Automatic Thresholding for Frame-Repositioning Using External Tracking in PET Brain Imaging

    DEFF Research Database (Denmark)

    Olesen, Oline Vinter; Keller, Sune; Sibomana, Merence

    2010-01-01

    present an automated algorithm for dividing PET acquisitions into subframes based on the registered head motion to correct for intra-frame motion with the frame repositioning MC method. The method is tested on real patient data (five 11C-SB studies and five 11C-PIB studies) and compared with an image...

  19. Considerações acerca do processo de alimentação de repositórios através da importação de registros de bases de dados internacionaisConsiderations around of process of uploading repositories via import records of international data bases

    Directory of Open Access Journals (Sweden)

    Renan Carvalho Ramos

    2012-06-01

    Full Text Available Considerando que há um interesse global e crescente na implementação de repositórios institucionais e que as discussões em âmbito nacional sobre esse tema tem sido modestas, e que poucas são as iniciativas consolidadas no desenvolvimento desses sistemas nas universidades brasileiras, este trabalho toma como tema a questão da carga automática de registros comentada pelas diretrizes do programa intercontinental Alfa Biblioteca Babel. Para demonstrar as possibilidades e limitações da carga automática de registros referenciais a partir de bases de dados internacionais foi feito um estudo que se dividiu em quatro etapas, que se resumem em: escolha de um software para simular um repositório; análise de formatos de exportação dos metadados de algumas bases de dados disponíveis no Portal de Periódicos Capes; prospecção de registros e conversões de formato dos metadados; e alimentação do repositório através da importação dos registros coletados, indicando os efeitos desta prática. Como resultados são apontados um conjunto de ponderações a respeito do método que deve ser empregado para um melhor uso da carga automática de registros. Acredita-se que a carga automática de registros referenciais tem muito a colaborar com o início do desenvolvimento dos repositórios, à medida que oferece visibilidade à produção cientifica, favorecendo as instituições na elaboração dos índices de produção científica extraídos a partir dos emergentes estudos webmétricos, sem desrepeitar os principios de direitos do autor ou das editoras. Palavras-chave: Bases de dados internacionais. Carga automática de registros. Importação de registros. Repositórios institucionais. Software GreenStone Abstract Whereas there is a growing global interest in the implementation of institutional repositories and discussions in the national sphere about this issue have been modest, and there are few consolidated initiatives to develop these

  20. Development of a video-based slurry sensor for on-line ash analysis. Final technical report, October 1, 1994--September 30, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Adel, G.T.; Luttrell, G.H.

    1996-12-02

    Automatic control of fine coal cleaning circuits has traditionally been limited by the lack of sensors for on-line ash analysis. Although several nuclear-based slurry analyzers are available, none have seen widespread acceptance. This is largely due to the fact that nuclear sensors are expensive and tend to be influenced by changes in seam type and pyrite content. In this investigation, an image analysis technique is used for on-line determination of ash content in fine coal slurries. The ash content of a flotation tailings stream is correlated to the mean gray level of the slurry. Based on a 90% prediction interval, an analysis of sensor performance indicates an accuracy of 73 {+-} 4% ash over a range from 65 - 90% ash. While this result is comparable to existing nuclear-based analyzers, the video-based system is only a fraction of the cost. The sensor is currently being used to monitor the column flotation tailings stream at the Middle Fork preparation plant owned and operated by Pittston Coal Company.

  1. Drug repositioning and repurposing: terminology and definitions in literature

    NARCIS (Netherlands)

    Langedijk, Joris; Mantel-Teeuwisse, Aukje K; Slijkerman, Diederick S; Schutjens, Marie-Hélène D B

    2015-01-01

    Drug repositioning and similar terms have been a trending topic in literature and represent novel drug development strategies. We analysed in a quantitative and qualitative manner how these terms were used and defined in the literature. In total, 217 articles referred to 'drug repositioning', 'drug

  2. Drug repositioning and repurposing: terminology and definitions in literature

    NARCIS (Netherlands)

    Langedijk, Joris; Mantel-Teeuwisse, Aukje K; Slijkerman, Diederick S; Schutjens, Marie-Hélène D B

    Drug repositioning and similar terms have been a trending topic in literature and represent novel drug development strategies. We analysed in a quantitative and qualitative manner how these terms were used and defined in the literature. In total, 217 articles referred to 'drug repositioning', 'drug

  3. The Liner Shipping Fleet Repositioning Problem with Cargo Flows

    DEFF Research Database (Denmark)

    Tierney, Kevin; Jensen, Rune Møller

    2012-01-01

    We solve an important problem for the liner shipping industry called the Liner Shipping Fleet Repositioning Problem (LSFRP). The LSFRP poses a large financial burden on liner shipping firms. During repositioning, vessels are moved between services in a liner shipping network. Shippers wish...

  4. Impact of Web Based Learning on EFL: Using On-Line Discussion Forum (ODF) to Enhance Students' Writing Skill

    Science.gov (United States)

    Akmal

    2017-01-01

    Web based learning is considered as a breakthrough in the teaching of writing skill to the pre-service teachers at University of PGRI Semarang, Indonesia. The students should write argumentative, persuasive, and descriptive essays. This research offers significant contribution in term of the impact of web based learning on writing skill of English…

  5. Development of a video-based slurry sensor for on-line ash analysis. Quarterly report, April 1, 1996--June 30, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Adel, G.T.; Luttrell, G.H.

    1996-07-22

    Automatic control of fine coal cleaning circuits has traditionally been limited by the lack of sensors for on-line ash analysis. Although several nuclear-based analyzers are available, none have seen widespread acceptance. This is largely due to the fact that nuclear sensors are expensive and tend to be influenced by changes in seam type and pyrite content. Recently, researchers at VPI&SU have developed an optical sensor for phosphate analysis. The sensor uses image processing technology to analyze video images of phosphate ore. It is currently being used by PCS Phosphate for off-line analysis of dry flotation concentrate. The primary advantages of optical sensors over nuclear sensors are that they are significantly cheaper, are not subject to measurement variations due to changes in high atomic number minerals, are inherently safer and require no special radiation permitting. The purpose of this work is to apply the knowledge gained in the development of an optical phosphate analyzer to the development of an on-line ash analyzer for fine coal slurries. During the past quarter, an industrially-hardened version of the video-based ash analyzer was designed and constructed. All components are now in place at the Middle Fork plant site awaiting the installation of a sample line from the flotation columns to the analyzer. The sensor now appears ready for long-term, in-plant testing during the final quarter of this project. 1 fig., 1 tab.

  6. Automatic on-line detection system design research on internal defects of metal materials based on optical fiber F-P sensing technology

    Science.gov (United States)

    Xia, Liu; Shan, Ning; Chao, Ban; Caoshan, Wang

    2016-10-01

    Metal materials have been used in aerospace and other industrial fields widely because of its excellent characteristics, so its internal defects detection is very important. Ultrasound technology is used widely in the fields of nondestructive detection because of its excellent characteristic. But the conventional detection instrument for ultrasound, which has shortcomings such as low intelligent level and long development cycles, limits its development. In this paper, the theory of ultrasound detection is analyzed. A computational method of the defects distributional position is given. The non-contact type optical fiber F-P interference cavity structure is designed and the length of origin cavity is given. The real-time on-line ultrasound detecting experiment devices for internal defects of metal materials is established based on the optical fiber F-P sensing system. The virtual instrument of automation ultrasound detection internal defects is developed based on LabVIEW software and the experimental study is carried out. The results show that this system can be used in internal defect real-time on-line locating of engineering structures effectively. This system has higher measurement precision. Relative error is 6.7%. It can be met the requirement of engineering practice. The system is characterized by simple operation, easy realization. The software has a friendly interface, good expansibility, and high intelligent level.

  7. Intermediate Greek EFL Learners' Attitudes to On-Line Teaching Practices: A Blended Task-Based English Language Learning Approach

    Science.gov (United States)

    Liontou, Trisevgeni

    2015-01-01

    This paper reports on a one-year longitudinal study that adopted a blended teaching approach based on designing and implementing an online EFL course to be used by Greek students aged 13-14 years old along their more traditional face-to-face lessons. The reason for creating a more dynamic learning environment aligned with the rest of the…

  8. Transient Fault Locating Method Based on Line Voltage and Zero-mode Current in Non-solidly Earthed Network

    Institute of Scientific and Technical Information of China (English)

    ZHANG Linli; XU Bingyin; XUE Yongduan; GAO Houlei

    2012-01-01

    Non-solidly earthed systems are widely used for middle voltage distribution network at home and abroad. Fault point location especially the single phase-to-earth fault is very difficult because the fault current is very weak and the fault arc is intermittent. Although several methods have been developed, the problem of fault location has not yet been resolved very well. A new fault location method based on transient component of line voltage and 0-mode current is presented in this paper, which can realize fault section location by the feeder automation (FA) system. Line voltage signal can be obtained conveniently without requiring any additional equipment. This method is based on transient information, not affected by arc suppression coil.

  9. A comparative analysis of on-line and classroom-based instructional formats for teaching social work research

    Directory of Open Access Journals (Sweden)

    David Westhuis

    2006-12-01

    Full Text Available Research comparing courses taught exclusively in traditional face-to-face settings versus courses taught entirely online have shown similar levels of student satisfaction. This article reports findings from a comparative study of student achievement in research skills from classes using two different instructional formats. One group used a classroom-based instructional format and the other group used an online web-based instructional format. Findings indicate that there were no statistically significant differences between the two class formats for eight out of eleven outcome student performance activities and ten out of 13 pedagogical strategies. There were large effect size differences based on class format on four of the student performance activities and for student satisfaction with six of the pedagogical methods. When statistically significant differences were found, it was determined that student performance on learning activities and satisfaction with pedagogical methods were higher for the students in the traditional class. The findings support the conclusions of several studies concerning the effectiveness of online teaching. Limitations and implications for further studies are also suggested.

  10. On-line Multiple-model Based Adaptive Control Reconfiguration for a Class of Non-linear Control Systems

    DEFF Research Database (Denmark)

    Yang, Z.; Izadi-Zamanabadi, Roozbeh; Blanke, M.

    2000-01-01

    Based on the model-matching strategy, an adaptive control reconfiguration method for a class of nonlinear control systems is proposed by using the multiple-model scheme. Instead of requiring the nominal and faulty nonlinear systems to match each other directly in some proper sense, three sets of ...... corresponding to the updating of local LTI models, which validations are determined by the model approximation errors and the optimal index of local design. The test on a nonlinear ship propulsion system shows the promising potential of this method for system reconfiguration...

  11. On-line monitoring of base current and forward emitter current gain of the voltage regulator's serial pnp transistor in a radiation environment

    Directory of Open Access Journals (Sweden)

    Vukić Vladimir Đ.

    2012-01-01

    Full Text Available A method of on-line monitoring of the low-dropout voltage regulator's operation in a radiation environment is developed in this paper. The method had to enable detection of the circuit's degradation during exploitation, without terminating its operation in an ionizing radiation field. Moreover, it had to enable automatic measurement and data collection, as well as the detection of any considerable degradation, well before the monitored voltage regulator's malfunction. The principal parameters of the voltage regulator's operation that were monitored were the serial pnp transistor's base current and the forward emitter current gain. These parameters were procured indirectly, from the data on the voltage regulator's load and quiescent currents. Since the internal consumption current in moderately and heavily loaded devices was used, the quiescent current of a negligibly loaded voltage regulator of the same type served as a reference. Results acquired by on-line monitoring demonstrated marked agreement with the results acquired from examinations of the voltage regulator's maximum output current and minimum dropout voltage in a radiation environment. The results were particularly consistent in tests with heavily loaded devices. Results obtained for moderately loaded voltage regulators and the risks accompanying the application of the presented method, were also analyzed.

  12. High resolution, on-line identification of strains from the Mycobacterium tuberculosis complex based on tandem repeat typing

    Directory of Open Access Journals (Sweden)

    Denoeud France

    2002-11-01

    Full Text Available Abstract Background Currently available reference methods for the molecular epidemiology of the Mycobacterium tuberculosis complex either lack sensitivity or are still too tedious and slow for routine application. Recently, tandem repeat typing has emerged as a potential alternative. This report contributes to the development of tandem repeat typing for M. tuberculosis by summarising the existing data, developing additional markers, and setting up a freely accessible, fast, and easy to use, internet-based service for strain identification. Results A collection of 21 VNTRs incorporating 13 previously described loci and 8 newly evaluated markers was used to genotype 90 strains from the M. tuberculosis complex (M. tuberculosis (64 strains, M. bovis (9 strains including 4 BCG representatives, M. africanum (17 strains. Eighty-four different genotypes are defined. Clustering analysis shows that the M. africanum strains fall into three main groups, one of which is closer to the M. tuberculosis strains, and an other one is closer to the M. bovis strains. The resulting data has been made freely accessible over the internet http://bacterial-genotyping.igmors.u-psud.fr/bnserver to allow direct strain identification queries. Conclusions Tandem-repeat typing is a PCR-based assay which may prove to be a powerful complement to the existing epidemiological tools for the M. tuberculosis complex. The number of markers to type depends on the identification precision which is required, so that identification can be achieved quickly at low cost in terms of consumables, technical expertise and equipment.

  13. Adaptive de-noising method based on wavelet and adaptive learning algorithm in on-line PD monitoring

    Institute of Scientific and Technical Information of China (English)

    王立欣; 诸定秋; 蔡惟铮

    2002-01-01

    It is an important step in the online monitoring of partial discharge (PD) to extract PD pulses from various background noises. An adaptive de-noising method is introduced for adaptive noise reduction during detection of PD pulses. This method is based on Wavelet Transform (WT) , and in the wavelet domain the noises decomposed at the levels are reduced by independent thresholds. Instead of the standard hard thresholding function, a new type of hard thresholding function with continuous derivative is employed by this method. For the selection of thresholds, an unsupervised learning algorithm based on gradient in a mean square error (MSE) is present to search for the optimal threshold for noise reduction, and the optimal threshold is selected when the minimum MSE is obtained. With the simulating signals and on-site experimental data processed by this method,it is shown that the background noises such as narrowband noises can be reduced efficiently. Furthermore, it is proved that in comparison with the conventional wavelet de-noising method the adaptive de-noising method has a better performance in keeping the pulses and is more adaptive when suppressing the background noises of PD signals.

  14. Solid-state Marx based two-switch voltage modulator for the On-Line Isotope Mass Separator accelerator at the European Organization for Nuclear Research.

    Science.gov (United States)

    Redondo, L M; Silva, J Fernando; Canacsinh, H; Ferrão, N; Mendes, C; Soares, R; Schipper, J; Fowler, A

    2010-07-01

    A new circuit topology is proposed to replace the actual pulse transformer and thyratron based resonant modulator that supplies the 60 kV target potential for the ion acceleration of the On-Line Isotope Mass Separator accelerator, the stability of which is critical for the mass resolution downstream separator, at the European Organization for Nuclear Research. The improved modulator uses two solid-state switches working together, each one based on the Marx generator concept, operating as series and parallel switches, reducing the stress on the series stacked semiconductors, and also as auxiliary pulse generator in order to fulfill the target requirements. Preliminary results of a 10 kV prototype, using 1200 V insulated gate bipolar transistors and capacitors in the solid-state Marx circuits, ten stages each, with an electrical equivalent circuit of the target, are presented, demonstrating both the improved voltage stability and pulse flexibility potential wanted for this new modulator.

  15. Characterization of temperature non-uniformity over a premixed CH4-air flame based on line-of-sight TDLAS

    Science.gov (United States)

    Zhang, Guangle; Liu, Jianguo; Xu, Zhenyu; He, Yabai; Kan, Ruifeng

    2016-01-01

    A novel technique for characterizing temperature non-uniformity has been investigated based on measurements of line-of-sight tunable diode laser absorption spectroscopy. It utilized two fiber-coupled distributed feedback diode lasers at wavelengths around 1339 and 1392 nm as light sources to probe the field at multiple absorptions lines of water vapor and applied a temperature binning strategy combined with Gauss-Seidel iteration method to explore the temperature non-uniformity of the field in one dimension. The technique has been applied to a McKenna burner, which produced a flat premixed laminar CH4-air flame. The flame and its adjacent area formed an atmospheric field with significant non-uniformity of temperature and water vapor concentration. The effect of the number of temperature bins on column-density and temperature results has also been explored.

  16. On-Line, Gyro-Based, Mass-Property Identification for Thruster-Controlled Spacecraft Using Recursive Least Squares

    Science.gov (United States)

    Wilson, Edward; Lages, Chris; Mah, Robert; Clancy, Daniel (Technical Monitor)

    2002-01-01

    Spacecraft control, state estimation, and fault-detection-and-isolation systems are affected by unknown v aerations in the vehicle mass properties. It is often difficult to accurately measure inertia terms on the ground, and mass properties can change on-orbit as fuel is expended, the configuration changes, or payloads are added or removed. Recursive least squares -based algorithms that use gyro signals to identify the center of mass and inverse inertia matrix are presented. They are applied in simulation to 3 thruster-controlled vehicles: the X-38 and Mini-AERCam under development at NASA-JSC, and the SAM, an air-bearing spacecraft simulator at the NASA-Ames Smart Systems Research Lab (SSRL).

  17. Premaxillary Repositioning in the Severe Form of Bilateral Cleft Lip and Palate.

    Science.gov (United States)

    Koh, Kyung S; Han, Woo Yeon; Jeong, Woo Shik; Oh, Tae Suk; Kwon, Sun Man; Choi, Jong Woo

    2016-09-01

    Severe forms of bilateral cleft lip and palate remain a challenging issue. Although nasoalveolar molding dramatically improves overall treatment success, the position of the premaxilla often remains dislocated. The authors attempted to relocate the malpositioned premaxilla into the correct position to obtain the correct three-dimensional (3D) maxillary arch structure and growth. Eight patients with severe bilateral cleft lip and palate were treated with premaxillary osteotomy for premaxilla repositioning. The position of the premaxilla was measured directly using cephalometry. Two raters including orthodontists evaluated the 3D (anteroposterior, transverse, and sagittal) outcomes. Regarding the long-term effects of premaxillary repositioning on midfacial growth, 3D computed tomography scan data were used, including the measurement of the SNA, SNB, and ANB angles according to the time period (T0: preoperative; T1: immediate postoperative; T2: long-term postoperative). All bilateral cleft lips and palates were satisfactorily repaired without any complications, including any premaxillary vascular compromise, nonunion, and occlusal instability. The average visual analog scale scores (0-5) of the anteroposterior, vertical, and transverse dimensions were 3.9, 3.7, and 3.2, respectively. Regarding the effect of premaxillary repositioning on midfacial hypoplasia, the change in the ANB between T1 and T2 was not significant, implying that premaxillary repositioning did not affect the long-term harmony between the maxilla and mandible (ANB of T2-T1: P = 0.1016) based on interim growth data at the time of follow-up and study completion. Premaxillary repositioning effectively corrected the malpositioned premaxilla and repaired the accompanying wide alveolar cleft, achieving successful restoration of maxillary arch coordination. In addition, premaxillary osteotomy after 8 years of age does not seem to cause significant maxillary retrusion.

  18. Ruptured disc after arthroscopic repositioning in the temporomandibular joint: a retrospective magnetic resonance imaging study.

    Science.gov (United States)

    Li, Hui; Cai, Xieyi; Yang, Chi; Wang, Shaoyi; Huang, Linjian

    2014-07-01

    Our aim was to explore the incidence of rupture after arthroscopic repositioning of the disc of the temporomandibular joint (TMJ) by reviewing magnetic resonance images (MRI) of the TMJ taken before and after operation, and to investigate correlations retrospectively. We studied 247 patients with anterior disc displacement of the TMJ, and categorised them into 3 groups based on the postoperative MRI. The first group comprised those whose disc ruptured after repositioning, the second those who had a possible rupture of the disc after repositioning, and the third had no rupture of the disc after repositioning. Age, sex, duration of symptoms, maximum incisal mouth opening, whether the anterior disc displacement was unilateral or bilateral, and the Wilkes stage, were included in the analysis. The incidence of rupture (5/247) was 2%. Weak points at the intermediate zone of the disc were found in 4 of the 5 joints. The patients whose discs ruptured were significantly younger than the other 2 groups (p=0.001). There was no statistically significant difference in preoperative duration of symptoms and mouth opening among the groups. The proportions of unilateral and bilateral disc displacement (p=0.047) and Wilkes stage (p=0.027) differed among the 3 groups. The Wilkes stages was significantly more advanced in the ruptured group than in the other 2 groups (p=0.027) with 4/5 being bilateral. The weak point in the intermediate zone of the disc on MRI could be a sign of rupture. Teenagers and young adults with anterior disc displacement without reduction, particularly those in whom it is bilateral, are at a higher risk of a rupture after repositioning of the disc by arthroscopy. Copyright © 2014 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

  19. Experimental study on the push-broom infrared imaging system based on line-plane-switching fiber bundle

    Science.gov (United States)

    Yan, Xingtao; Li, Fu; Ma, Xiaolong; Lv, Juan; He, Yinghong; Zhao, Yiyi; Bu, Fan

    2016-10-01

    The use of line-plane-switching infrared fiber bundle to achieve wide field of view push-broom infrared imaging has been studied with experiment. In this technology, the linear array end of the imaging fiber bundle is used as a long-linear array infrared detector, and the plane array end of the bundle is coupled by a mature small scale Infrared Focal Plane Array (IRFPA). It can evade the difficulty of getting the long-linear array infrared detector directly, and has a signally significance to the development of internal infrared imaging technology. Based on the introduction of the composition, working principle of this novel infrared optical system, the system principle-demonstrating experiment has been accomplished. The line-plane-switching fiber bundle used in this experiment is 64×9 format plane array and 192×3 format linear array. It is made from chalcogenide glass fibers, possessing core (As40S59.5Se0.5) of 45 μm, cladding (As40S60) of 5 μm, and error of 1% in diameter. Perfect imaging results prove that this novel technology is feasibility and superiority. The analysis of the experiment makes a foundation for the subsequent further verification experiments.

  20. Repositioning a decentered intraocular lens with 4 haptics.

    Science.gov (United States)

    Liu, Jiewei; Liu, Wenjie; Jia, Yading; Al-Mohtaseb, Zaina N; Wang, Li

    2016-03-01

    We describe a technique to reposition a decentered 4-haptic intraocular lens (IOL). Using an ophthalmic viscosurgical device, the haptic with the worst distortion is dissected from the capsular bag and pulled outside the bag. The opposite haptic (180 degrees away) is also dissected and placed in front of the anterior capsule. The remaining 2 haptics are left in the capsular bag. With this repositioning, the 2 haptics in the bag limit the IOL movement, the 2 haptics outside the bag are no longer distorted, and the IOL is centered. We present 2 cases in which this technique was used to reposition decentered 4-haptic IOLs.

  1. Sensorless FOC Performance Improved with On-Line Speed and Rotor Resistance Estimator Based on an Artificial Neural Network for an Induction Motor Drive.

    Science.gov (United States)

    Gutierrez-Villalobos, Jose M; Rodriguez-Resendiz, Juvenal; Rivas-Araiza, Edgar A; Martínez-Hernández, Moisés A

    2015-06-29

    Three-phase induction motor drive requires high accuracy in high performance processes in industrial applications. Field oriented control, which is one of the most employed control schemes for induction motors, bases its function on the electrical parameter estimation coming from the motor. These parameters make an electrical machine driver work improperly, since these electrical parameter values change at low speeds, temperature changes, and especially with load and duty changes. The focus of this paper is the real-time and on-line electrical parameters with a CMAC-ADALINE block added in the standard FOC scheme to improve the IM driver performance and endure the driver and the induction motor lifetime. Two kinds of neural network structures are used; one to estimate rotor speed and the other one to estimate rotor resistance of an induction motor.

  2. Self-tuning wireless power transmission scheme based on on-line scattering parameters measurement and two-side power matching.

    Science.gov (United States)

    Luo, Yanting; Yang, Yongmin; Chen, Zhongsheng

    2014-04-10

    Sub-resonances often happen in wireless power transmission (WPT) systems using coupled magnetic resonances (CMR) due to environmental changes, coil movements or component degradations, which is a serious challenge for high efficiency power transmission. Thus self-tuning is very significant to keep WPT systems following strongly magnetic resonant conditions in practice. Traditional coupled-mode ways is difficult to solve this problem. In this paper a two-port power wave model is presented, where power matching and the overall systemic power transmission efficiency are firstly defined by scattering (S) parameters. Then we propose a novel self-tuning scheme based on on-line S parameters measurements and two-side power matching. Experimental results testify the feasibility of the proposed method. These findings suggest that the proposed method is much potential to develop strongly self-adaptive WPT systems with CMR.

  3. Sensorless FOC Performance Improved with On-Line Speed and Rotor Resistance Estimator Based on an Artificial Neural Network for an Induction Motor Drive

    Directory of Open Access Journals (Sweden)

    Jose. M. Gutierrez-Villalobos

    2015-06-01

    Full Text Available Three-phase induction motor drive requires high accuracy in high performance processes in industrial applications. Field oriented control, which is one of the most employed control schemes for induction motors, bases its function on the electrical parameter estimation coming from the motor. These parameters make an electrical machine driver work improperly, since these electrical parameter values change at low speeds, temperature changes, and especially with load and duty changes. The focus of this paper is the real-time and on-line electrical parameters with a CMAC-ADALINE block added in the standard FOC scheme to improve the IM driver performance and endure the driver and the induction motor lifetime. Two kinds of neural network structures are used; one to estimate rotor speed and the other one to estimate rotor resistance of an induction motor.

  4. Miniaturized DNA aptamer-based monolithic sorbent for selective extraction of a target analyte coupled on-line to nanoLC.

    Science.gov (United States)

    Brothier, Fabien; Pichon, Valérie

    2014-12-01

    A complete characterization of a novel target-specific DNA aptamer-based miniaturized solid phase extraction (SPE)-sorbent coupled on-line to nanoLC is presented. A miniaturized oligosorbent (mOS) was prepared via the in situ sol-gel synthesis of a hybrid organic-inorganic monolith in 100 μm i.d. capillary columns using tetraethoxysilane and 3-aminopropyltriethoxysilane as precursors, followed by covalent binding of a 5'-amino-modified DNA aptamer with a C12 spacer arm specific for a molecule of small molecular weight. Ochratoxin A (OTA), one of the most abundant naturally occurring mycotoxins, was chosen as model analyte to demonstrate the principle of such an approach. The mOS was coupled on-line to RP-nanoLC-LIF. Selective extraction of OTA on several mOSs was demonstrated with an average extraction recovery above 80 % when percolating spiked binding buffer and a low recovery on control monoliths grafted with a non-specific aptamer. Reproducibility of mOSs preparation was highlighted by comparing extraction yields. Otherwise, the mOSs demonstrated no cross-reactivity towards an OTA structural analogue, i.e., ochratoxin B. Due to the high specific surface area of the hybrid silica-based monolith, the coverage density of DNA aptamers covalently immobilized in the capillaries was very high and reached 6.27 nmol μL(-1), thus leading to a capacity above 5 ng of OTA. This miniaturized device was then applied to the selective extraction of OTA from beer samples. It revealed to be effective in isolating OTA from this complex matrix, thus improving the reliability of its analysis at the trace level.

  5. On-line liquid phase micro-extraction based on drop-in-plug sequential injection lab-at-valve platform for metal determination

    Energy Technology Data Exchange (ETDEWEB)

    Mitani, Constantina [Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University, Thessaloniki 54124 (Greece); Anthemidis, Aristidis N., E-mail: anthemid@chem.auth.gr [Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University, Thessaloniki 54124 (Greece)

    2013-04-10

    Highlights: ► Drop-in-plug micro-extraction based on SI-LAV platform for metal preconcentration. ► Automatic liquid phase micro-extraction coupled with FAAS. ► Organic solvents with density higher than water are used. ► Lead determination in environmental water and urine samples. -- Abstract: A novel automatic on-line liquid phase micro-extraction method based on drop-in-plug sequential injection lab-at-valve (LAV) platform was proposed for metal preconcentration and determination. A flow-through micro-extraction chamber mounted at the selection valve was adopted without the need of sophisticated lab-on-valve components. Coupled to flame atomic absorption spectrometry (FAAS), the potential of this lab-at-valve scheme is demonstrated for trace lead determination in environmental and biological water samples. A hydrophobic complex of lead with ammonium pyrrolidine dithiocarbamate (APDC) was formed on-line and subsequently extracted into an 80 μL plug of chloroform. The extraction procedure was performed by forming micro-droplets of aqueous phase into the plug of the extractant. All critical parameters that affect the efficiency of the system were studied and optimized. The proposed method offered good performance characteristics and high preconcentration ratios. For 10 mL sample consumption an enhancement factor of 125 was obtained. The detection limit was 1.8 μg L{sup −1} and the precision expressed as relative standard deviation (RSD) at 50.0 μg L{sup −1} of lead was 2.9%. The proposed method was evaluated by analyzing certified reference materials and applied for lead determination in natural waters and urine samples.

  6. A PDDL Domain for the Liner Shipping Fleet Repositioning Problem

    DEFF Research Database (Denmark)

    Tierney, Kevin; Coles, Amanda; Coles, Andrew

    The Liner Shipping Fleet Repositioning Problem (LSFRP) poses a large financial burden on liner shipping firms. During repositioning, vessels are moved between services in a liner shipping network. The LSFRP is characterized by chains of interacting activities, many of which have costs that are a ......The Liner Shipping Fleet Repositioning Problem (LSFRP) poses a large financial burden on liner shipping firms. During repositioning, vessels are moved between services in a liner shipping network. The LSFRP is characterized by chains of interacting activities, many of which have costs...... that are a function of their duration; for example, sailing slowly between two ports is cheaper than sailing quickly. Despite its great industrial importance, the LSFRP has received little attention in the literature. We model the LSFRP using PDDL and solve it using the planner....

  7. The repositioning of literature in French foreign language teaching ...

    African Journals Online (AJOL)

    The repositioning of literature in French foreign language teaching in South Africa: ... a disciplinary tradition evident in both corpus and teaching methods. ... themselves from traditional approaches in their shift from text-centredness to ...

  8. A Systematic Framework for Drug Repositioning from Integrated Omics and Drug Phenotype Profiles Using Pathway-Drug Network

    Directory of Open Access Journals (Sweden)

    Erkhembayar Jadamba

    2016-01-01

    Full Text Available Drug repositioning offers new clinical indications for old drugs. Recently, many computational approaches have been developed to repurpose marketed drugs in human diseases by mining various of biological data including disease expression profiles, pathways, drug phenotype expression profiles, and chemical structure data. However, despite encouraging results, a comprehensive and efficient computational drug repositioning approach is needed that includes the high-level integration of available resources. In this study, we propose a systematic framework employing experimental genomic knowledge and pharmaceutical knowledge to reposition drugs for a specific disease. Specifically, we first obtain experimental genomic knowledge from disease gene expression profiles and pharmaceutical knowledge from drug phenotype expression profiles and construct a pathway-drug network representing a priori known associations between drugs and pathways. To discover promising candidates for drug repositioning, we initialize node labels for the pathway-drug network using identified disease pathways and known drugs associated with the phenotype of interest and perform network propagation in a semisupervised manner. To evaluate our method, we conducted some experiments to reposition 1309 drugs based on four different breast cancer datasets and verified the results of promising candidate drugs for breast cancer by a two-step validation procedure. Consequently, our experimental results showed that the proposed framework is quite useful approach to discover promising candidates for breast cancer treatment.

  9. Multi-aspect candidates for repositioning: data fusion methods using heterogeneous information sources.

    Science.gov (United States)

    Arany, Á; Bolgár, B; Balogh, B; Antal, P; Mátyus, P

    2013-01-01

    Drug repositioning, an innovative therapeutic application of an old drug, has received much attention as a particularly costeffective strategy in drug R&D Recent work has indicated that repositioning can be promoted by utilizing a wide range of information sources, including medicinal chemical, target, mechanism, main and side-effect-related information, and also bibliometric and taxonomical fingerprints, signatures and knowledge bases. This article describes the adaptation of a conceptually novel, more efficient approach for the identification of new possible therapeutic applications of approved drugs and drug candidates, based on a kernel-based data fusion method. This strategy includes (1) the potentially multiple representation of information sources, (2) the automated weighting and statistically optimal combination of information sources, and (3) the automated weighting of parts of the query compounds. The performance was systematically evaluated by using Anatomical Therapeutic Chemical Classification System classes in a cross-validation framework. The results confirmed that kernel-based data fusion can integrate heterogeneous information sources significantly better than standard rank-based fusion can, and this method provides a unique solution for repositioning; it can also be utilized for de novo drug discovery. The advantages of kernel-based data fusion are illustrated with examples and open problems that are particularly relevant for pharmaceutical applications.

  10. Development of a video-based slurry sensor for on-line ash analysis. Sixth quarterly technical progress report, January 1, 1996--March 31, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Adel, G.T.; Luttrell, G.H.

    1996-04-28

    Automatic control of fine coal cleaning circuits has traditionally been limited by the lack of sensors for on-line ash analysis. Although several nuclear-based analyzers are available, none have seen widespread acceptance. This is largely due to the fact that nuclear sensors are expensive and tend to be influenced by changes in seam type and pyrite content. Recently, researchers at VPI&SU have developed an optical sensor for phosphate analysis. The sensor uses image processing technology to analyze video images of phosphate ore. It is currently being used by PCS Phosphate for off-line analysis of dry flotation concentrate. The primary advantages of optical sensors over nuclear sensors are that they are significantly cheaper, are not subject to measurement variations due to changes in high atomic number minerals, are inherently safer and require no special radiation permitting. The purpose of this work is to apply the knowledge gained in the development of an optical phosphate analyzer to the development of an on-line ash analyzer for fine coal slurries. During the past quarter, calibration tests were conducted on-site at the Middle Fork coal preparation plant owned and operated by Pittston Coal Company. After several plant visits, a consistent sensor calibration was obtained with approximately 95% of all samples analyzed falling within {plus_minus}2% ash of the best fit calibration line. The resolution of the optical analyzer was found to be approximately 0.5% ash per gray level increment. A linear neural network learning algorithm was found to be the most appropriate method for calibrating the sensor. The sensor now appears to be ready for installation and long-term testing at the Middle Fork test site.

  11. The determination of organochlorine pesticides based on dynamic microwave-assisted extraction coupled with on-line solid-phase extraction of high-performance liquid chromatography

    Energy Technology Data Exchange (ETDEWEB)

    Chen Ligang [College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (China); Ding Lan [College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (China)]. E-mail: analchem@jlu.edu.cn; Jin Haiyan [College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (China); Song Daqian [College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (China); Zhang Huarong [College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (China); Li Jiantao [College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (China); Zhang Kun [College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (China); Wang Yutang [College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (China); Zhang Hanqi [College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (China)

    2007-04-25

    A rapid technique based on dynamic microwave-assisted extraction coupled with on-line solid-phase extraction of high-performance liquid chromatography (DMAE-SPE-HPLC) has been developed. A TM{sub 010} microwave resonance cavity built in the laboratory was applied to concentrate the microwave energy. The sample placed in the zone of microwave irradiation was extracted with 95% acetonitrile (ACN) aqueous solution which was driven by a peristaltic pump at a flow rate of 1.0 mL min{sup -1}. The extraction can be completed in a recirculating system in 10 min. When a number of extraction cycles were completed, the extract (1 mL) was diluted on-line with water. Then the extract was loaded into an SPE column where the analytes were retained while the unretained matrix components were washed away. Subsequently, the analytes were automatically transferred from the SPE column to the analytical column and determined by UV detector at 238 nm. The technique was used for determination of organochlorine pesticides (OCPs) in grains, including wheat, rice, corn and bean. The limits of detection of OCPs are in the range of 19-37 ng g{sup -1}. The recoveries obtained by analyzing the four spiked grain samples are in the range of 86-105%, whereas the relative standard deviation (R.S.D.) values are <8.7% ranging from 1.2 to 8.7%. Our method was demonstrated to be fast, accurate, and precise. In addition, only small quantities of solvent and sample were required.

  12. Product of Likelihood Ratio Scores Fusion of Dynamic Face, Text Independent Speech and On-line Signature Based Biometrics Verification Application Systems

    Directory of Open Access Journals (Sweden)

    Mohamed SOLTANE

    2015-09-01

    Full Text Available In this paper, the use of finite Gaussian mixture modal (GMM tuned using Expectation Maximization (EM estimating algorithms for score level data fusion is proposed. Automated biometric systems for human identification measure a “signature” of the human body, compare the resulting characteristic to a database, and render an application dependent decision. These biometric systems for personal authentication and identification are based upon physiological or behavioral features which are typically distinctive, Multi-biometric systems, which consolidate information from multiple biometric sources, are gaining popularity because they are able to overcome limitations such as non-universality, noisy sensor data, large intra-user variations and susceptibility to spoof attacks that are commonly encountered in mono modal biometric systems. Simulation result show that finite mixture modal (GMM is quite effective in modelling the genuine and impostor score densities, fusion based the product of Likelihood Ratio achieves a significant performance on eNTERFACE 2005 multi-biometric database based on dynamic face, on-line signature and text independent speech modalities.

  13. 在线参数辨识的脉冲噪声有源控制%Active Control of Impulsive Noise Based on On-line Parameter Identification

    Institute of Scientific and Technical Information of China (English)

    杨琴; 周亚丽; 张奇志

    2013-01-01

    Active noise control is a kind of active control methods and has been widely used to attenuate the noise which yields Gaussian distribution. But for most of non-Gaussian impulsive noises, the traditional adaptive algorithms are not appropriate for controlling the impulsive noise. The main reason is that there is no finite second-order moment for the impulsive noise. In this paper, two kinds of on-line parameter identification algorithms based on the classical Filter-x LMS algorithm were presented which are appropriate for non-Gaussian impulsive noise. One is FxLMPest and FxLMADadapt algorithms based on on-line parameters identification to estimate characteristics exponent of impulsive noise with an SαS distribution, and the other is BDP algorithm based on SKM and AM algorithms presented by Sun et al, which uses a simple on-line recursive procedure to estimate amplitude thresholds. Both methods do not need prior information of characteristics exponent and amplitude thresholds of impulsive noise. And the simulation results also show that the two methods can effectively suppress the impulsive noise, and its robust performance is significantly better than Filter-x LMS algorithm.%  有源噪声控制是一种主动控制方法,目前已广泛应用于对高斯分布噪声进行衰减。但是传统的用于控制噪声的自适应算法不再适用大多数服从非高斯分布的脉冲噪声,主要原因是这种脉冲噪声没有有限的二阶统计量。在经典的Filter-x LMS算法的基础上提出两种适用于服从非高斯分布尖峰脉冲噪声情况下的在线参数辨识方法,一种是利用在线参数辨识方法对服从SαS稳定分布的脉冲噪声进行特征指数的估计,进而实现降噪目的的FxLMPest和FxLMADadapt算法;另一种是在Sun等人提出的SKM和AM算法基础上利用在线递归过程实现对幅度阈值估计的BDP算法。这两种算法均不需要获得脉冲噪声的特征指数和阈值的

  14. A Novel Hybrid Error Criterion-Based Active Control Method for on-Line Milling Vibration Suppression with Piezoelectric Actuators and Sensors.

    Science.gov (United States)

    Zhang, Xingwu; Wang, Chenxi; Gao, Robert X; Yan, Ruqiang; Chen, Xuefeng; Wang, Shibin

    2016-01-06

    Milling vibration is one of the most serious factors affecting machining quality and precision. In this paper a novel hybrid error criterion-based frequency-domain LMS active control method is constructed and used for vibration suppression of milling processes by piezoelectric actuators and sensors, in which only one Fast Fourier Transform (FFT) is used and no Inverse Fast Fourier Transform (IFFT) is involved. The correction formulas are derived by a steepest descent procedure and the control parameters are analyzed and optimized. Then, a novel hybrid error criterion is constructed to improve the adaptability, reliability and anti-interference ability of the constructed control algorithm. Finally, based on piezoelectric actuators and acceleration sensors, a simulation of a spindle and a milling process experiment are presented to verify the proposed method. Besides, a protection program is added in the control flow to enhance the reliability of the control method in applications. The simulation and experiment results indicate that the proposed method is an effective and reliable way for on-line vibration suppression, and the machining quality can be obviously improved.

  15. Design of an expert system based on neuro-fuzzy inference analyzer for on-line microstructural characterization using magnetic NDT method

    Energy Technology Data Exchange (ETDEWEB)

    Ghanei, S., E-mail: Sadegh.Ghanei@yahoo.com [Department of Materials Engineering, Faculty of Engineering, Ferdowsi University of Mashhad, Azadi Square, Mashhad (Iran, Islamic Republic of); Vafaeenezhad, H. [Centre of Excellence for High Strength Alloys Technology (CEHSAT), School of Metallurgical and Materials Engineering, Iran University of Science and Technology (IUST), Narmak, Tehran (Iran, Islamic Republic of); Kashefi, M. [Department of Materials Engineering, Faculty of Engineering, Ferdowsi University of Mashhad, Azadi Square, Mashhad (Iran, Islamic Republic of); Eivani, A.R. [Centre of Excellence for High Strength Alloys Technology (CEHSAT), School of Metallurgical and Materials Engineering, Iran University of Science and Technology (IUST), Narmak, Tehran (Iran, Islamic Republic of); Mazinani, M. [Department of Materials Engineering, Faculty of Engineering, Ferdowsi University of Mashhad, Azadi Square, Mashhad (Iran, Islamic Republic of)

    2015-04-01

    Tracing microstructural evolution has a significant importance and priority in manufacturing lines of dual-phase steels. In this paper, an artificial intelligence method is presented for on-line microstructural characterization of dual-phase steels. A new method for microstructure characterization based on the theory of magnetic Barkhausen noise nondestructive testing method is introduced using adaptive neuro-fuzzy inference system (ANFIS). In order to predict the accurate martensite volume fraction of dual-phase steels while eliminating the effect and interference of frequency on the magnetic Barkhausen noise outputs, the magnetic responses were fed into the ANFIS structure in terms of position, height and width of the Barkhausen profiles. The results showed that ANFIS approach has the potential to detect and characterize microstructural evolution while the considerable effect of the frequency on magnetic outputs is overlooked. In fact implementing multiple outputs simultaneously enables ANFIS to approach to the accurate results using only height, position and width of the magnetic Barkhausen noise peaks without knowing the value of the used frequency. - Highlights: • New NDT system for microstructural evaluation based on MBN using ANFIS modeling. • Sensitivity of magnetic Barkhausen noise to microstructure changes of the DP steels. • Accurate prediction of martensite by feeding multiple MBN outputs simultaneously. • Obtaining the modeled output without knowing the amount of the used frequency.

  16. A Novel Hybrid Error Criterion-Based Active Control Method for on-Line Milling Vibration Suppression with Piezoelectric Actuators and Sensors

    Directory of Open Access Journals (Sweden)

    Xingwu Zhang

    2016-01-01

    Full Text Available Milling vibration is one of the most serious factors affecting machining quality and precision. In this paper a novel hybrid error criterion-based frequency-domain LMS active control method is constructed and used for vibration suppression of milling processes by piezoelectric actuators and sensors, in which only one Fast Fourier Transform (FFT is used and no Inverse Fast Fourier Transform (IFFT is involved. The correction formulas are derived by a steepest descent procedure and the control parameters are analyzed and optimized. Then, a novel hybrid error criterion is constructed to improve the adaptability, reliability and anti-interference ability of the constructed control algorithm. Finally, based on piezoelectric actuators and acceleration sensors, a simulation of a spindle and a milling process experiment are presented to verify the proposed method. Besides, a protection program is added in the control flow to enhance the reliability of the control method in applications. The simulation and experiment results indicate that the proposed method is an effective and reliable way for on-line vibration suppression, and the machining quality can be obviously improved.

  17. Biomonitoring of essential and toxic metals in single hair using on-line solution-based calibration in laser ablation inductively coupled plasma mass spectrometry.

    Science.gov (United States)

    Dressler, Valderi L; Pozebon, Dirce; Mesko, Marcia Foster; Matusch, Andreas; Kumtabtim, Usarat; Wu, B; Sabine Becker, J

    2010-10-15

    Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has been established as a powerful and sensitive surface analytical technique for the determination of concentration and distribution of trace metals within biological systems at micrometer spatial resolution. LA-ICP-MS allows easy quantification procedures if suitable standard references materials (SRM) are available. In this work a new SRM-free approach of solution-based calibration method in LA-ICP-MS for element quantification in hair is described. A dual argon flow of the carrier gas and nebulizer gas is used. A dry aerosol produced by laser ablation (LA) of biological sample and a desolvated aerosol generated by pneumatic nebulization (PN) of standard solutions are carried by two different flows of argon as carrier or nebulizer gas, respectively and introduced separately in the injector tube of a special ICP torch, through two separated apertures. Both argon flows are mixed directly in the ICP torch. External calibration via defined standard solutions before analysis of single hair was employed as calibration strategy. A correction factor, calculated using hair with known analyte concentration (measured by ICP-MS), is applied to correct the different elemental sensitivities of ICP-MS and LA-ICP-MS. Calibration curves are obtained by plotting the ratio of analyte ion M(+)/(34)S(+) ion intensities measured using LA-ICP-MS in dependence of analyte concentration in calibration solutions. Matrix-matched on-line calibration in LA-ICP-MS is carried out by ablating of human hair strands (mounted on a sticky tape in the LA chamber) using a focused laser beam in parallel with conventional nebulization of calibration solutions. Calibrations curves of Li, Na, Mg, Al, K, V, Cr, Mn, Fe, Ni, Co, Cu, Zn, Sr, Mo, Ag, Cd, I, Hg, Pb, Tl, Bi and U are presented. The linear correlation coefficients (R) of calibration curves for analytes were typically between 0.97 and 0.999. The limits of detection (LODs) of

  18. Systematic drug repositioning through mining adverse event data in ClinicalTrials.gov.

    Science.gov (United States)

    Su, Eric Wen; Sanger, Todd M

    2017-01-01

    Drug repositioning (i.e., drug repurposing) is the process of discovering new uses for marketed drugs. Historically, such discoveries were serendipitous. However, the rapid growth in electronic clinical data and text mining tools makes it feasible to systematically identify drugs with the potential to be repurposed. Described here is a novel method of drug repositioning by mining ClinicalTrials.gov. The text mining tools I2E (Linguamatics) and PolyAnalyst (Megaputer) were utilized. An I2E query extracts "Serious Adverse Events" (SAE) data from randomized trials in ClinicalTrials.gov. Through a statistical algorithm, a PolyAnalyst workflow ranks the drugs where the treatment arm has fewer predefined SAEs than the control arm, indicating that potentially the drug is reducing the level of SAE. Hypotheses could then be generated for the new use of these drugs based on the predefined SAE that is indicative of disease (for example, cancer).

  19. Systematic drug repositioning through mining adverse event data in ClinicalTrials.gov

    Directory of Open Access Journals (Sweden)

    Eric Wen Su

    2017-03-01

    Full Text Available Drug repositioning (i.e., drug repurposing is the process of discovering new uses for marketed drugs. Historically, such discoveries were serendipitous. However, the rapid growth in electronic clinical data and text mining tools makes it feasible to systematically identify drugs with the potential to be repurposed. Described here is a novel method of drug repositioning by mining ClinicalTrials.gov. The text mining tools I2E (Linguamatics and PolyAnalyst (Megaputer were utilized. An I2E query extracts “Serious Adverse Events” (SAE data from randomized trials in ClinicalTrials.gov. Through a statistical algorithm, a PolyAnalyst workflow ranks the drugs where the treatment arm has fewer predefined SAEs than the control arm, indicating that potentially the drug is reducing the level of SAE. Hypotheses could then be generated for the new use of these drugs based on the predefined SAE that is indicative of disease (for example, cancer.

  20. On-line generalized Steiner problem

    Energy Technology Data Exchange (ETDEWEB)

    Awerbuch, B.; Azar, Y.; Bartal, Y. [Tel Aviv Univ. (Israel)

    1996-12-31

    The Generalized Steiner Problem (GSP) is defined as follows. We are given a graph with non-negative weights and a set of pairs of vertices. The algorithm has to construct minimum weight subgraph such that the two nodes of each pair are connected by a path. We consider the on-line generalized Steiner problem, in which pairs of vertices arrive on-line and are needed to be connected immediately. We give a simple O(log{sup 2} n) competitive deterministic on-line algorithm. The previous best online algorithm (by Westbrook and Yan) was O({radical}n log n) competitive. We also consider the network connectivity leasing problem which is a generalization of the GSP. Here edges of the graph can be either bought or leased for different costs. We provide simple randomized O(log{sup 2} n) competitive algorithm based on the on-line generalized Steiner problem result.

  1. Nucleosome Repositioning: A Novel Mechanism for Nicotine- and Cocaine-Induced Epigenetic Changes.

    Directory of Open Access Journals (Sweden)

    Amber N Brown

    Full Text Available Drugs of abuse modify behavior by altering gene expression in the brain. Gene expression can be regulated by changes in DNA methylation as well as by histone modifications, which alter chromatin structure, DNA compaction and DNA accessibility. In order to better understand the molecular mechanisms directing drug-induced changes in chromatin structure, we examined DNA-nucleosome interactions within promoter regions of 858 genes in human neuroblastoma cells (SH-SY5Y exposed to nicotine or cocaine. Widespread, drug- and time-resolved repositioning of nucleosomes was identified at the transcription start site and promoter region of multiple genes. Nicotine and cocaine produced unique and shared changes in terms of the numbers and types of genes affected, as well as repositioning of nucleosomes at sites which could increase or decrease the probability of gene expression based on DNA accessibility. Half of the drug-induced nucleosome positions approximated a theoretical model of nucleosome occupancy based on physical and chemical characteristics of the DNA sequence, whereas the basal or drug naïve positions were generally DNA sequence independent. Thus we suggest that nucleosome repositioning represents an initial dynamic genome-wide alteration of the transcriptional landscape preceding more selective downstream transcriptional reprogramming, which ultimately characterizes the cell- and tissue-specific responses to drugs of abuse.

  2. Nucleosome Repositioning: A Novel Mechanism for Nicotine- and Cocaine-Induced Epigenetic Changes.

    Science.gov (United States)

    Brown, Amber N; Vied, Cynthia; Dennis, Jonathan H; Bhide, Pradeep G

    2015-01-01

    Drugs of abuse modify behavior by altering gene expression in the brain. Gene expression can be regulated by changes in DNA methylation as well as by histone modifications, which alter chromatin structure, DNA compaction and DNA accessibility. In order to better understand the molecular mechanisms directing drug-induced changes in chromatin structure, we examined DNA-nucleosome interactions within promoter regions of 858 genes in human neuroblastoma cells (SH-SY5Y) exposed to nicotine or cocaine. Widespread, drug- and time-resolved repositioning of nucleosomes was identified at the transcription start site and promoter region of multiple genes. Nicotine and cocaine produced unique and shared changes in terms of the numbers and types of genes affected, as well as repositioning of nucleosomes at sites which could increase or decrease the probability of gene expression based on DNA accessibility. Half of the drug-induced nucleosome positions approximated a theoretical model of nucleosome occupancy based on physical and chemical characteristics of the DNA sequence, whereas the basal or drug naïve positions were generally DNA sequence independent. Thus we suggest that nucleosome repositioning represents an initial dynamic genome-wide alteration of the transcriptional landscape preceding more selective downstream transcriptional reprogramming, which ultimately characterizes the cell- and tissue-specific responses to drugs of abuse.

  3. Cyclic pentapeptide analogs based on endomorphin-2 structure: cyclization studies using liquid chromatography combined with on-line mass spectrometry and tandem mass spectrometry.

    Science.gov (United States)

    Piekielna, Justyna; Kluczyk, Alicja; Perlikowska, Renata; Janecka, Anna

    2014-05-01

    The cyclization of linear analogs based on endomorphin-2 structure, Tyr/Dmt-d-Lys-Phe-Phe-Asp-NH2 and Tyr/Dmt-d-Cys-Phe-Phe-Cys-NH2 (where Dmt=2',6'-dimethyltyrosine), resulting in obtaining lactam or disulfide derivatives, was studied using liquid chromatography combined with on-line mass spectrometry (LC-MS) and tandem mass spectrometry (LC-MS/MS). In case of cyclization via an amide bond, the formation of the cyclic monomers, cyclic but not linear dimers and even traces of cyclic trimers was observed. Disulfide bridge containing peptides was obtained by the solid-phase synthesis of the linear sequences, followed by either in-solution or on-resin cyclization. In case of the in-solution cyclization, the expected cyclic monomers were the only products. When oxidation of the cysteine residues was performed when the peptides were still on the resin, cyclic monomer and two cyclodimers, parallel and antiparallel, were found. Digestion of the isolated cyclodimers with α-chymotrypsin allowed for their unambiguous identification. The comparison of the cyclic monomer/dimer ratios for analogs with Tyr versus Dmt in position 1 revealed that the presence of the exocyclic Dmt favored formation of the cyclic monomer, most likely due to the increased steric bulk of this amino acid side-chain as compared with Tyr.

  4. [Determination of estrogen residues in drinking water by on-line solid phase extraction based on sol-gel technique coupled with high performance liquid chromatography].

    Science.gov (United States)

    Li, Longfei; Su, Min; Shi, Xiaolei; Wang, Yana; Wang, Minmin; He, Jinxing

    2014-02-01

    A method for the determination of diethylstilbestrol (DES), hexestrol (HEX) and dienestrol (DS) residues in drinking water was established by on-line solid phase extraction (SPE) coupled with high performance liquid chromatography (HPLC). The material synthesized on the base of sol-gel technology was employed as adsorbent. This material was prepared using 3-aminopropyltriethoxysilane (APTES) as the functional monomer, tetraethoxysilane (TEOS) as the crosslinking agent, and acetic acid as the initiator. The synthesized adsorbent showed outstanding property for the estrogen extraction. The estrogen can be caught effectively from water samples and the extraction can be achieved rapidly. Some important parameters, such as pH of sample solution, eluent solvents, loading flow rate, which might influence extraction efficiency, were optimized. The results indicated that the limit of detection (S/N = 3) of the developed method could reach 0.07-0.13 microg/L under the conditions of pH 7.0 of sample solution, methanol and 1% (v/v) acetic acid aqueous solution as the eluent solvent and the loading flow rate of 2 mL/min. The recoveries of the three estrogens from the water samples at three spiked levels ranged from 82.31% to 99.43% with RSD of 1.61%-7.15%. The method was simple, rapid, and suitable to detect the trace residues of estrogens in drinking water.

  5. Design of an expert system based on neuro-fuzzy inference analyzer for on-line microstructural characterization using magnetic NDT method

    Science.gov (United States)

    Ghanei, S.; Vafaeenezhad, H.; Kashefi, M.; Eivani, A. R.; Mazinani, M.

    2015-04-01

    Tracing microstructural evolution has a significant importance and priority in manufacturing lines of dual-phase steels. In this paper, an artificial intelligence method is presented for on-line microstructural characterization of dual-phase steels. A new method for microstructure characterization based on the theory of magnetic Barkhausen noise nondestructive testing method is introduced using adaptive neuro-fuzzy inference system (ANFIS). In order to predict the accurate martensite volume fraction of dual-phase steels while eliminating the effect and interference of frequency on the magnetic Barkhausen noise outputs, the magnetic responses were fed into the ANFIS structure in terms of position, height and width of the Barkhausen profiles. The results showed that ANFIS approach has the potential to detect and characterize microstructural evolution while the considerable effect of the frequency on magnetic outputs is overlooked. In fact implementing multiple outputs simultaneously enables ANFIS to approach to the accurate results using only height, position and width of the magnetic Barkhausen noise peaks without knowing the value of the used frequency.

  6. Sensor Fusion Based on an Integrated Neural Network and Probability Density Function (PDF) Dual Kalman Filter for On-Line Estimation of Vehicle Parameters and States.

    Science.gov (United States)

    Vargas-Melendez, Leandro; Boada, Beatriz L; Boada, Maria Jesus L; Gauchia, Antonio; Diaz, Vicente

    2017-04-29

    Vehicles with a high center of gravity (COG), such as light trucks and heavy vehicles, are prone to rollover. This kind of accident causes nearly 33 % of all deaths from passenger vehicle crashes. Nowadays, these vehicles are incorporating roll stability control (RSC) systems to improve their safety. Most of the RSC systems require the vehicle roll angle as a known input variable to predict the lateral load transfer. The vehicle roll angle can be directly measured by a dual antenna global positioning system (GPS), but it is expensive. For this reason, it is important to estimate the vehicle roll angle from sensors installed onboard in current vehicles. On the other hand, the knowledge of the vehicle's parameters values is essential to obtain an accurate vehicle response. Some of vehicle parameters cannot be easily obtained and they can vary over time. In this paper, an algorithm for the simultaneous on-line estimation of vehicle's roll angle and parameters is proposed. This algorithm uses a probability density function (PDF)-based truncation method in combination with a dual Kalman filter (DKF), to guarantee that both vehicle's states and parameters are within bounds that have a physical meaning, using the information obtained from sensors mounted on vehicles. Experimental results show the effectiveness of the proposed algorithm.

  7. A pipeline VLSI design of fast singular value decomposition processor for real-time EEG system based on on-line recursive independent component analysis.

    Science.gov (United States)

    Huang, Kuan-Ju; Shih, Wei-Yeh; Chang, Jui Chung; Feng, Chih Wei; Fang, Wai-Chi

    2013-01-01

    This paper presents a pipeline VLSI design of fast singular value decomposition (SVD) processor for real-time electroencephalography (EEG) system based on on-line recursive independent component analysis (ORICA). Since SVD is used frequently in computations of the real-time EEG system, a low-latency and high-accuracy SVD processor is essential. During the EEG system process, the proposed SVD processor aims to solve the diagonal, inverse and inverse square root matrices of the target matrices in real time. Generally, SVD requires a huge amount of computation in hardware implementation. Therefore, this work proposes a novel design concept for data flow updating to assist the pipeline VLSI implementation. The SVD processor can greatly improve the feasibility of real-time EEG system applications such as brain computer interfaces (BCIs). The proposed architecture is implemented using TSMC 90 nm CMOS technology. The sample rate of EEG raw data adopts 128 Hz. The core size of the SVD processor is 580×580 um(2), and the speed of operation frequency is 20MHz. It consumes 0.774mW of power during the 8-channel EEG system per execution time.

  8. 基于线段特征匹配的EKF-SLAM算法%EKF-SLAM Algorithm Based on Line Segment Matching

    Institute of Scientific and Technical Information of China (English)

    张国良; 汤文俊; 敬斌; 程展欣

    2012-01-01

    针对EKF-SLAM算法在机器人被“绑架”时失效的问题,提出一种新的基于线段特征匹配的EKF-SLAM算法——EKFLineSLAM算法.该算法在线段特征观测模型和改进的基于逐点搜索的线段提取算法的基础上,将线段特征匹配引入EKF-SLAM算法,并对线段长度和姿态角进行EKF更新,创建环境的线段特征地图.在未知室内结构化环境中,将该算法与弱匹配EKFLineSLAM算法进行比较,验证了EKFLineSLAM算法在结构化环境中克服机器人“绑架”问题的可行性和有效性.%For the problem of EKF-SLAM algorithm being invalid when robot is kidnapped, a new EKF-SLAM algorithm called "EKF-LineSLAM Algorithm" based on line segment matching is presented. This algorithm is based on the line segment observation model, and the improved line segment extraction algorithm based on point by point search. It introduces the line segment match in the EKF-SLAM algorithm, and renews the line segment's length and posture angle by EKF to find the line segment characteristic map. Finally, the presented algorithm and the weak matching EKFLineSLAM algorithm are compared in an unknown structured indoor environment. The comparison results confirm the feasibility and the effectiveness of the EKFLineSLAM algorithm for the kidnapped robot problem in structured environments.

  9. The Research About On-line Detection of Workpiece Based on Machine Vision%基于机器视觉的工件的在线检测

    Institute of Scientific and Technical Information of China (English)

    潘武; 张莉彦; 徐俊成

    2012-01-01

    利用HALCON软件提供的算子对摄像机内、外参数和机器人“手眼”系统进行标定,在此基础上结合视觉检测技术提出了一种工件在线缺陷检测的方法.该方法是根据触发时刻的空间位置来确定抓取时刻工件位置的一种空间相量平移方法,接着利用图像处理软件发出的电信号来控制机械手来完成缺陷工件的动态抓取工作.最后利用C++完成人机界面的设计,经调试可完成实时在线检测、可达到生产要求精度.%This article introduce mainly the calibration of the inside and outside parameters of the camera calibration and the calibration of robot " eye-hand" system based on the operator provided by HALCON software, and based on this, presents a workpiece on-line defect insepction methods combined with visual inspection technology. This method is based on the spatial position of triggering time to determine the grab a space time phasor translation methods, then use the image processing software to control the electric signals of a robotic arm to complete the dynamic grab defects. Final finish the interface design by u-sing C++ software. After debugging, this system can complete real-time online detection, and can a-chieve production requirements precision.

  10. Cervical spine reposition errors after cervical flexion and extension.

    Science.gov (United States)

    Wang, Xu; Lindstroem, René; Carstens, Niels Peter Bak; Graven-Nielsen, Thomas

    2017-03-13

    Upright head and neck position has been frequently applied as baseline for diagnosis of neck problems. However, the variance of the position after cervical motions has never been demonstrated. Thus, it is unclear if the baseline position varies evenly across the cervical joints. The purpose was to assess reposition errors of upright cervical spine. Cervical reposition errors were measured in twenty healthy subjects (6 females) using video-fluoroscopy. Two flexion movements were performed with a 20 s interval, the same was repeated for extension, with an interval of 5 min between flexion and extension movements. Cervical joint positions were assessed with anatomical landmarks and external markers in a Matlab program. Reposition errors were extracted in degrees (initial position minus reposition) as constant errors (CEs) and absolute errors (AEs). Twelve of twenty-eight CEs (7 joints times 4 repositions) exceeded the minimal detectable change (MDC), while all AEs exceeded the MDC. Averaged AEs across the cervical joints were larger after 5 min' intervals compared to 20 s intervals (p cervical spine. The cervical spine returns to the upright positions with a 2° average absolute difference after cervical flexion and extension movements in healthy adults.

  11. A Distributed System for Learning Programming On-Line

    Science.gov (United States)

    Verdu, Elena; Regueras, Luisa M.; Verdu, Maria J.; Leal, Jose P.; de Castro, Juan P.; Queiros, Ricardo

    2012-01-01

    Several Web-based on-line judges or on-line programming trainers have been developed in order to allow students to train their programming skills. However, their pedagogical functionalities in the learning of programming have not been clearly defined. EduJudge is a project which aims to integrate the "UVA On-line Judge", an existing…

  12. Repositioning drugs for inflammatory disease – fishing for new anti-inflammatory agents

    Directory of Open Access Journals (Sweden)

    Christopher J. Hall

    2014-09-01

    Full Text Available Inflammation is an important and appropriate host response to infection or injury. However, dysregulation of this response, with resulting persistent or inappropriate inflammation, underlies a broad range of pathological processes, from inflammatory dermatoses to type 2 diabetes and cancer. As such, identifying new drugs to suppress inflammation is an area of intense interest. Despite notable successes, there still exists an unmet need for new effective therapeutic approaches to treat inflammation. Traditional drug discovery, including structure-based drug design, have largely fallen short of satisfying this unmet need. With faster development times and reduced safety and pharmacokinetic uncertainty, drug repositioning – the process of finding new uses for existing drugs – is emerging as an alternative strategy to traditional drug design that promises an improved risk-reward trade-off. Using a zebrafish in vivo neutrophil migration assay, we undertook a drug repositioning screen to identify unknown anti-inflammatory activities for known drugs. By interrogating a library of 1280 approved drugs for their ability to suppress the recruitment of neutrophils to tail fin injury, we identified a number of drugs with significant anti-inflammatory activity that have not previously been characterized as general anti-inflammatories. Importantly, we reveal that the ten most potent repositioned drugs from our zebrafish screen displayed conserved anti-inflammatory activity in a mouse model of skin inflammation (atopic dermatitis. This study provides compelling evidence that exploiting the zebrafish as an in vivo drug repositioning platform holds promise as a strategy to reveal new anti-inflammatory activities for existing drugs.

  13. Texts On-Line.

    Science.gov (United States)

    Thomas, Jean-Jacques

    1993-01-01

    Maintains that the study of signs is divided between those scholars who use the Saussurian binary sign (semiology) and those who prefer the Peirce tripartite sign (semiotics). Concludes that neither the Saussurian nor Peircian analysis methods can produce a semiotic interpretation based on a hierarchy of the text's various components. (CFR)

  14. Texts On-Line.

    Science.gov (United States)

    Thomas, Jean-Jacques

    1993-01-01

    Maintains that the study of signs is divided between those scholars who use the Saussurian binary sign (semiology) and those who prefer the Peirce tripartite sign (semiotics). Concludes that neither the Saussurian nor Peircian analysis methods can produce a semiotic interpretation based on a hierarchy of the text's various components. (CFR)

  15. Transcriptomic profiling of human hippocampal progenitor cells treated with antidepressants and its application in drug repositioning

    Science.gov (United States)

    Powell, Timothy R; Murphy, Tytus; Lee, Sang H; Price, Jack; Thuret, Sandrine; Breen, Gerome

    2017-01-01

    Current pharmacological treatments for major depressive disorder (MDD) are ineffective in a significant proportion of patients, and the identification of new antidepressant compounds has been difficult. ‘Connectivity mapping’ is a method that can be used to identify drugs that elicit similar downstream effects on mRNA levels when compared to current treatments, and thus may point towards possible repositioning opportunities. We investigated genome-wide transcriptomic changes to human hippocampal progenitor cells treated with therapeutically relevant concentrations of a tricyclic antidepressant (nortriptyline) and a selective serotonin reuptake inhibitor (escitalopram). We identified mRNA changes common to both drugs to create an ‘antidepressant mRNA signature’. We used this signature to probe the Library of Integrated Network-based Cellular Signatures (LINCS) and to identify other compounds that elicit similar changes to mRNA in neural progenitor cells. Results from LINCS revealed that the tricyclic antidepressant clomipramine elicited mRNA changes most similar to our mRNA signature, and we identified W-7 and vorinostat as functionally relevant drug candidates, which may have repositioning potential. Our results are encouraging and represent the first attempt to use connectivity mapping for drug repositioning in MDD. PMID:28208023

  16. Pharmacologically active metabolites, combination screening and target identification-driven drug repositioning in antituberculosis drug discovery.

    Science.gov (United States)

    Kigondu, Elizabeth M; Wasuna, Antonina; Warner, Digby F; Chibale, Kelly

    2014-08-15

    There has been renewed interest in alternative strategies to address bottlenecks in antibiotic development. These include the repurposing of approved drugs for use as novel anti-infective agents, or their exploitation as leads in drug repositioning. Such approaches are especially attractive for tuberculosis (TB), a disease which remains a leading cause of morbidity and mortality globally and, increasingly, is associated with the emergence of drug-resistance. In this review article, we introduce a refinement of traditional drug repositioning and repurposing strategies involving the development of drugs that are based on the active metabolite(s) of parental compounds with demonstrated efficacy. In addition, we describe an approach to repositioning the natural product antibiotic, fusidic acid, for use against Mycobacterium tuberculosis. Finally, we consider the potential to exploit the chemical matter arising from these activities in combination screens and permeation assays which are designed to confirm mechanism of action (MoA), elucidate potential synergies in polypharmacy, and to develop rules for drug permeability in an organism that poses a special challenge to new drug development. Copyright © 2014 Elsevier Ltd. All rights reserved.

  17. Management of intrusive luxation with immediate surgical repositioning

    Directory of Open Access Journals (Sweden)

    Mazumdar Dibyendu

    2009-01-01

    Full Text Available Intrusive luxation is one of the most severe forms of traumatic injuries in which the affected tooth is forced to displace deeper into the alveolus. As a consequence of this type of injury, maximum damage occurs to the pulp and all the supporting structures. This report presents a case of severe intrusive luxation of mature maxillary central and lateral incisor in a 40-year-old male. The intruded tooth was immediately repositioned (surgical extrusion and splinted within hours following injury. Antibiotic therapy was initiated at the time of repositioning and maintained for 5 days. Pulp removal and calcium hydroxide treatment of the root canal was carried out after repositioning. Splint was removed 2 months later. Definitive root canal treatment with Gutta percha was accomplished at a later appointment. Clinical and radiographic examination 6, 12 and 24 months after the surgical extrusion revealed satisfactory progressive apical and periodontal healing.

  18. Repositioning of pedicle conjunctival flap performed for refractory corneal ulcer

    Directory of Open Access Journals (Sweden)

    Ashok Sharma

    2014-01-01

    Full Text Available A 50-year-old male was referred with a previous history of conjunctival flap (CF for a nonhealing fungal corneal ulcer with extreme corneal thinning in the right eye. The peritomy for the CF extended from 6:30 to 9:30 clock h on the cornea. The CF was disengaged, peritomy area deepithelialized, and CF was repositioned. He later underwent penetrating keratoplasty and achieved 20/40 best corrected visual acuity. The authors present a new concept for surgically repositioning CF s to the original site immediately after healing of the corneal ulcer.

  19. Repositioning of pedicle conjunctival flap performed for refractory corneal ulcer.

    Science.gov (United States)

    Sharma, Ashok; Mohan, Kanwar; Sharma, Rajan; Nirankari, Verinder S

    2014-01-01

    A 50-year-old male was referred with a previous history of conjunctival flap (CF) for a nonhealing fungal corneal ulcer with extreme corneal thinning in the right eye. The peritomy for the CF extended from 6:30 to 9:30 clock h on the cornea. The CF was disengaged, peritomy area deepithelialized, and CF was repositioned. He later underwent penetrating keratoplasty and achieved 20/40 best corrected visual acuity. The authors present a new concept for surgically repositioning CF s to the original site immediately after healing of the corneal ulcer.

  20. Solving the Liner Shipping Fleet Repositioning Problem with Cargo Flows

    DEFF Research Database (Denmark)

    Tierney, Kevin; Askelsdottir, Björg; Jensen, Rune Møller

    2015-01-01

    We solve a central problem in the liner shipping industry called the liner shipping fleet repositioning problem (LSFRP). The LSFRP poses a large financial burden on liner shipping firms. During repositioning, vessels are moved between routes in a liner shipping network. Liner carriers wish...... introduce a novel mathematical model and a simulated annealing algorithm for the LSFRP with cargo flows that makes use of a carefully constructed graph; we evaluate these approaches using real-world data from our industrial collaborator. Additionally, we compare the performance of our approach against...

  1. Management of excessive gingival display: Lip repositioning technique

    Directory of Open Access Journals (Sweden)

    Upasana Sthapak

    2015-01-01

    Full Text Available The lips form the frame of a smile and define the esthetic zone. Excessive gingival display during smile is often referred to as "gummy smile". A successful management of excessive gingival display with lip repositioning procedure has shown excellent results. The procedure involves removing a strip of partial thickness mucosa from maxillary vestibule, then suturing it back to the lip mucosa at the level of mucogingival junction. This technique results in restricted muscle pull and a narrow vestibule, thereby reducing the gingival display. In this case gummy smile was treated by modification of Rubinstein and Kostianovsky′s surgical lip repositioning technique which resulted in a harmonious smile.

  2. Molecularly imprinted sol-gel nanofibers based solid phase microextraction coupled on-line with high performance liquid chromatography for selective determination of acesulfame.

    Science.gov (United States)

    Moein, Mohammad Mahdi; Javanbakht, Mehran; Karimi, Mohammad; Akbari-adergani, Behrouz

    2015-03-01

    Sol-gel based molecularly imprinted polymer (MIP) nanofiber was successfully fabricated by electrospinning technique on the surface of a stainless steel bar. The manufactured tool was applied for on-line selective solid phase microextraction (SPME) and determination of acesulfame (ACF) as an artificial sweetener with high performance liquid chromatography (HPLC). The selective ability of method for the extraction of ACF was investigated in the presence of some selected sweeteners such as saccharine (SCH), aspartame (ASP) and caffeine (CAF). Electrospinning of MIP sol-gel solution on the stainless steel bar provided an unbreakable sorbent with high thermal, mechanical, and chemical stability. Moreover, application of the MIP-SPME tool revealed a unique approach for the selective microextraction of the analyte in beverage samples. In this work, 3-(triethoxysilyl)-propylamine (TMSPA) was chosen as a precursor due to its ability to imprint the analyte by hydrogen bonding, Van der Walls, and dipole-dipole interactions. Nylon 6 was also added as a backbone and support for the precursor in which sol could greatly growth during the sol-gel process and makes the solution electrospinable. Various effective parameters in the extraction efficiency of the MIP-SPME tool such as loading time, flow rate, desorption time, selectivity, and the sample volume were evaluated. The linearity for the ACF in beverage sample was in the range of 0.78-100.5 ng mL(-1). Limit of detection (LOD) and quantification (LOQ) were 0.23 and 0.78 ng mL(-1) respectively. The RSD values (n=5) were all below 3.5%at the 20 ng mL(-1) level.

  3. Meditsiin on-line

    Directory of Open Access Journals (Sweden)

    Mare Kõiva

    2008-08-01

    , polite and serious. A closer look at the construction and vocabulary of the doctor-patient communication act reveals that the most common features are formality and distancing – the partners are not equal in their sociopolitical standing. Inter-patient discussion groups are more varied in their style of communication and language use, ranging from informational notices to narratives and displays of emotion. A discussion concerning a visit to a folk healer is treated at more length. Interaction of this kind is a discussion that preserves the individual characteristics of many people in writing. Opinions are individualised, making the discussion similar to oral dialogue in which different strategies are used in reasoning. The posted messages reflect natural personal language use in forms ranging from informational notices to lengthy narratives. The general attitude is supportive and trusting towards official medicine and the personal reactions to social and situational events. A medical discussion board comprises a conditional group that does not form a network or community but engages in a dialogue to obtain and provide expert opinion. Users of patients’ discussion group and their narratives have a close connection to reality. The Internet offers the users new ways to share their practices and experiences and sometimes supports or even provides alternatives not available in offline reality. Such groups are based on information sharing and narratives and play an important role in maintaining emotional stability.

  4. E-Learning, E-Teaching, E-Assessment: Aspects of Course Design for On-Line Web Based Courses Used with EFL/ESL Learners.

    Science.gov (United States)

    Canning-Wilson, Christine

    Traditional means of education and assessment will cease to exist as distance learning and on-line courses become more available to students. This paper looks at issues of e-content, e-grading, and e-assessment in the world of teaching English as a Foreign Language (EFL)/English as a Second Language (ESL). The paper further examines the process…

  5. Research on One High Precision Megnetic Heading System Based on on-line Estimation and Correction of Remnant Devia- tion with Neural Network

    Institute of Scientific and Technical Information of China (English)

    Xu,Guanlei; Ge,Dehong; Ji,Chunsheng

    2003-01-01

    This paper presented one high precision megneticheading system,and use neural network to correct the remnantdeviation of compass.This system can study on-line and be tak-en into practice directly,which not only realize the automation ofcorrection of deviation of compass and improve the effficiency,butalso raise the precision of this megnetic heading system.

  6. Formación on line

    Directory of Open Access Journals (Sweden)

    O. Grau-Perejoan

    Full Text Available La formación on line es una modalidad de enseñanza a distancia basada en las nuevas tecnologías. En este artículo se pretende hacer una introducción a base de describir a grandes rasgos sus características principales: asincronía, no presencialidad, comunicación escrita, función del profesor on line, así como los retos, los riesgos, las ventajas y los inconvenientes que plantea. Se exponen las diferencias entre la formación on line y la formación presencial, de manera que los docentes puedan adaptar de la mejor manera posible sus propuestas formativas a la modalidad on line. Se introduce el importantísimo papel de la planificación y de la fase de diseño y, finalmente, se repasan conceptos útiles para comprender mejor el mundo de la formación on line como son los conceptos entorno virtual de aprendizaje (EVA o Blended Learning (B-Learning.

  7. Computational and experimental advances in drug repositioning for accelerated therapeutic stratification.

    Science.gov (United States)

    Shameer, Khader; Readhead, Ben; Dudley, Joel T

    2015-01-01

    Drug repositioning is an important component of therapeutic stratification in the precision medicine paradigm. Molecular profiling and more sophisticated analysis of longitudinal clinical data are refining definitions of human diseases, creating needs and opportunities to re-target or reposition approved drugs for alternative indications. Drug repositioning studies have demonstrated success in complex diseases requiring improved therapeutic interventions as well as orphan diseases without any known treatments. An increasing collection of available computational and experimental methods that leverage molecular and clinical data enable diverse drug repositioning strategies. Integration of translational bioinformatics resources, statistical methods, chemoinformatics tools and experimental techniques (including medicinal chemistry techniques) can enable the rapid application of drug repositioning on an increasingly broad scale. Efficient tools are now available for systematic drug-repositioning methods using large repositories of compounds with biological activities. Medicinal chemists along with other translational researchers can play a key role in various aspects of drug repositioning. In this review article, we briefly summarize the history of drug repositioning, explain concepts behind drug repositioning methods, discuss recent computational and experimental advances and highlight available open access resources for effective drug repositioning investigations. We also discuss recent approaches in utilizing electronic health record for outcome assessment of drug repositioning and future avenues of drug repositioning in the light of targeting disease comorbidities, underserved patient communities, individualized medicine and socioeconomic impact.

  8. An automated method for the analysis of phenolic acids in plasma based on ion-pairing micro-extraction coupled on-line to gas chromatography/mass spectrometry with in-liner derivatisation

    NARCIS (Netherlands)

    Peters, S.; Kaal, E.; Horsting, I.; Janssen, H.-G.

    2012-01-01

    A new method is presented for the analysis of phenolic acids in plasma based on ion-pairing ‘Micro-extraction in packed sorbent’ (MEPS) coupled on-line to in-liner derivatisation-gas chromatography-mass spectrometry (GC-MS). The ion-pairing reagent served a dual purpose. It was used both to improve

  9. Educational On-Line Gaming Propensity

    DEFF Research Database (Denmark)

    Sudzina, Frantisek; Razmerita, Liana; Kirchner, Kathrin

    2014-01-01

    Educational on-line games are promising for new generations of students who are grown up digital. Th e new generations of students are technology savvy and spend lots of time on the web and on social networks. Based on an exploratory study, this article investigates the factors that infl uence...... students’ willingness to participate in serious games for teaching/learning. Th is study investigates the relationship between students’ behavior on Facebook, Facebook games, and their attitude toward educational on-line games. Th e results of the study reveal that the early adopters of educational games...

  10. Repositioning for the Future: Franklin and Marshall College.

    Science.gov (United States)

    Hoffman, Richard B.

    1992-01-01

    Franklin and Marshall College (Pennsylvania) has used institutional mission, strategic planning, lessons learned from previous experience, and sound general management principles to guide reallocation of resources during a period of financial constraint. The objective was repositioning, not retrenchment, and the resulting academic program is…

  11. Repositioning Ideology Critique in a Critical Theory of Adult Learning.

    Science.gov (United States)

    Brookfield, Stephen

    2001-01-01

    Reexamines critical theory as a response to Marxism and repositions ideology critique as a crucial adult learning process. Argues that a critical theory of adult learning should focus on how adults learn to recognize and challenge ideological domination and manipulation. (Contains 31 references.) (SK)

  12. Control of grid integrated voltage source converters under unbalanced conditions: development of an on-line frequency-adaptive virtual flux-based approach

    Energy Technology Data Exchange (ETDEWEB)

    Suul, Jon Are

    2012-03-15

    Three-Phase Voltage Source Converters (VSCs) are finding widespread applications in grid integrated power conversion systems. The control systems of such VSCs are in an increasing number of these applications required to operate during voltage disturbances and unbalanced conditions. Control systems designed for grid side voltagesensor-less operation are at the same time becoming attractive due to the continuous drive for cost reduction and increased reliability of VSCs, but are not commonly applied for operation during unbalanced conditions. Methods for voltage-sensor-less grid synchronization and control of VSCs under unbalanced grid voltage conditions will therefore be the main focus of this Thesis. Estimation methods based on the concept of Virtual Flux, considering the integral of the converter voltage in analogy to the flux of an electric machine, are among the simplest and most well known techniques for achieving voltage-sensor-less grid synchronization. Most of the established techniques for Virtual Flux estimation are, however, either sensitive to grid frequency variations or they are not easily adaptable for operation under unbalanced grid voltage conditions. This Thesis addresses both these issues by proposing a simple approach for Virtual Flux estimation by utilizing a frequency-adaptive filter based on a Second Order Generalized Integrator (SOGI). The proposed approach can be used to achieve on-line frequency-adaptive varieties of conventional strategies for Virtual Flux estimation. The main advantage is, however, that the SOGI-based Virtual Flux estimation can be arranged in a structure that achieves inherent symmetrical component sequence separation under unbalanced conditions. The proposed method for Virtual Flux estimation can be used as a general basis for voltage-sensor-less grid synchronization and control during unbalanced conditions. In this Thesis, the estimated Virtual Flux signals are used to develop a flexible strategy for control of active

  13. Repositioning of Memantine as a Potential Novel Therapeutic Agent against Meningitic E. coli-Induced Pathogenicities through Disease-Associated Alpha7 Cholinergic Pathway and RNA Sequencing-Based Transcriptome Analysis of Host Inflammatory Responses.

    Directory of Open Access Journals (Sweden)

    Jing-Yi Yu

    Full Text Available Neonatal sepsis and meningitis (NSM remains a leading cause worldwide of mortality and morbidity in newborn infants despite the availability of antibiotics over the last several decades. E. coli is the most common gram-negative pathogen causing NSM. Our previous studies show that α7 nicotinic receptor (α7 nAChR, an essential regulator of inflammation, plays a detrimental role in the host defense against NSM. Despite notable successes, there still exists an unmet need for new effective therapeutic approaches to treat this disease. Using the in vitro/in vivo models of the blood-brain barrier (BBB and RNA-seq, we undertook a drug repositioning study to identify unknown antimicrobial activities for known drugs. We have demonstrated for the first time that memantine (MEM, a FDA-approved drug for treatment of Alzheimer's disease, could very efficiently block E. coli-caused bacteremia and meningitis in a mouse model of NSM in a manner dependent on α7 nAChR. MEM was able to synergistically enhance the antibacterial activity of ampicillin in HBMEC infected with E. coli K1 (E44 and in neonatal mice with E44-caused bacteremia and meningitis. Differential gene expression analysis of RNA-Seq data from mouse BMEC infected with E. coli K1 showed that several E44-increased inflammatory factors, including IL33, IL18rap, MMP10 and Irs1, were significantly reduced by MEM compared to the infected cells without drug treatment. MEM could also significantly up-regulate anti-inflammatory factors, including Tnfaip3, CISH, Ptgds and Zfp36. Most interestingly, these factors may positively and negatively contribute to regulation of NF-κB, which is a hallmark feature of bacterial meningitis. Furthermore, we have demonstrated that circulating BMEC (cBMEC are the potential novel biomarkers for NSM. MEM could significantly reduce E44-increased blood level of cBMEC in mice. Taken together, our data suggest that memantine can efficiently block host inflammatory responses to

  14. Research and Design of On-line Monitoring System of XLPE Cable Based on Water Tree Phenomenon%基于水树枝现象XLPE电缆在线监测系统的研究与设计

    Institute of Scientific and Technical Information of China (English)

    周笑阳; 杨建华; 卢伟

    2015-01-01

    基于交联聚乙烯(XLPE)电缆水树状老化的原理,直流分量法和交流叠加法是两种有效的XLPE电缆在线监测方法。设计了综合上述两种方法的在线监测系统,其中包括设计方案、系统构成、关键技术等。结果表明:设计的XLPE电缆在线监测系统能够反映运行中电缆绝缘的老化程度,实现了XLPE电缆的在线监测。%Based on the theory of water tree ageing of XLPE cable, the DC component method and AC superposition method are effective methods for on-line monitoring of XLPE cable. An on-line monitoring system of XLPE cable based on the above two methods was designed, which included design plan, system construction, and key technology. The experiment results show that the on-line monitoring system can reflect the ageing degree of the running cable, and realize the on-line monitoring of the cable.

  15. 決策樹形式知識之線上預測系統架構 | An On-Line Decision Tree-Based Predictive System Architecture

    Directory of Open Access Journals (Sweden)

    馬芳資、林我聰 Fang-Tz Ma、Woo-Tsong Lin

    2003-10-01

    ="font-size: small;">This paper presents an on-line decision tree-based predictive system architecture. The architecture contains nine components, including a database of the examples, a learning system of the decision trees, a knowledge base, a historical knowledge base, a maintaining interface of the decision trees, an interface to upload training and testing examples, a PMML (Predictive Model Markup Language translator, an on-line predictive system, and a merging optional decision trees system. There are three channels to import knowledge in the architecture; the developers can upload the examples to the learning system to induce the decision tree, directly input the information of decision trees through the user interface, or import the decision trees in PMML format. In order to integrate the knowledge of the decision trees, we added the merging optional decision trees system into this architecture. The merging optional decision trees system can combine multiple decision trees into a single decision tree to integrate the knowledge of the trees. In the future research, we will implement this architecture as a real system in the web-based platform to do some empirical analyses. And in order to improve the performance of the merging decision trees, we will also develop some pruning strategies in the merging optional decision trees system.

  16. Temporomandibular Joint Condylar Changes Following Maxillomandibular Advancement and Articular Disc Repositioning

    Science.gov (United States)

    Goncalves, Joao Roberto; Wolford, Larry Miller; Cassano, Daniel Serra; da Porciuncula, Guilherme; Paniagua, Beatriz; Cevidanes, Lucia Helena

    2014-01-01

    Purpose To evaluate condylar changes 1 year after bimaxillary surgical advancement with or without articular disc repositioning using longitudinal quantitative measurements in 3-dimensional (3D) temporomandibular joint (TMJ) models. Methods Twenty-seven patients treated with maxillomandibular advancement (MMA) underwent cone-beam computed tomography before surgery immediately after surgery and at 1-year follow-up. All patients underwent magnetic resonance imaging before surgery to assess disc displacements. Ten patients without disc displacement received MMA only. Seventeen patients with articular disc displacement received MMA with simultaneous TMJ disc repositioning (MMA-Drep). Pre- and postsurgical 3D models were superimposed using a voxel-based registration on the cranial base. Results The location, direction, and magnitude of condylar changes were displayed and quantified by graphic semitransparent overlays and 3D color-coded surface distance maps. Rotational condylar displacements were similar in the 2 groups. Immediately after surgery, condylar translational displacements of at least 1.5 mm occurred in a posterior, superior, or mediolateral direction in patients treated with MMA, whereas patients treated with MMA-Drep presented more marked anterior, inferior, and mediolateral condylar displacements. One year after surgery, more than half the patients in the 2 groups presented condylar resorptive changes of at least 1.5 mm. Patients treated with MMA-Drep presented condylar bone apposition of at least 1.5 mm at the superior surface in 26.4%, the anterior surface in 23.4%, the posterior surface in 29.4%, the medial surface in 5.9%, or the lateral surface in 38.2%, whereas bone apposition was not observed in patients treated with MMA. Conclusions One year after surgery, condylar resorptive changes greater than 1.5 mm were observed in the 2 groups. Articular disc repositioning facilitated bone apposition in localized condylar regions in patients treated with MMA

  17. Drug repositioning in SLE: crowd-sourcing, literature-mining and Big Data analysis.

    Science.gov (United States)

    Grammer, A C; Ryals, M M; Heuer, S E; Robl, R D; Madamanchi, S; Davis, L S; Lauwerys, B; Catalina, M D; Lipsky, P E

    2016-09-01

    Lupus patients are in need of modern drugs to treat specific manifestations of their disease effectively and safely. In the past half century, only one new treatment has been approved by the US Food and Drug Administration (FDA) for systemic lupus erythematosus (SLE). In 2014-2015, the FDA approved 71 new drugs, only one of which targeted a rheumatic disease and none of which was approved for use in SLE. Repositioning/repurposing drugs approved for other diseases using multiple approaches is one possible means to find new treatment options for lupus patients. "Big Data" analysis approaches this challenge from an unbiased standpoint whereas literature mining and crowd sourcing for candidates assessed by the CoLTs (Combined Lupus Treatment Scoring) system provide a hypothesis-based approach to rank potential therapeutic candidates for possible clinical application. Both approaches mitigate risk since the candidates assessed have largely been extensively tested in clinical trials for other indications. The usefulness of a multi-pronged approach to drug repositioning in lupus is highlighted by orthogonal confirmation of hypothesis-based drug repositioning predictions by "Big Data" analysis of differentially expressed genes from lupus patient samples. The goal is to identify novel therapies that have the potential to affect disease processes specifically. Involvement of SLE patients and the scientists that study this disease in thinking about new drugs that may be effective in lupus though crowd-sourcing sites such as LRxL-STAT (www.linkedin.com/in/lrxlstat) is important in stimulating the momentum needed to test these novel drug targets for efficacy in lupus rapidly in small, proof-of-concept trials conducted by LuCIN, the Lupus Clinical Investigators Network (www.linkedin.com/in/lucinstat). © The Author(s) 2016.

  18. CERN Video News on line

    CERN Multimedia

    2003-01-01

    The latest CERN video news is on line. In this issue : an interview with the Director General and reports on the new home for the DELPHI barrel and the CERN firemen's spectacular training programme. There's also a vintage video news clip from 1954. See: www.cern.ch/video or Bulletin web page

  19. Condylar repositioning using centric relation bite in bimaxillary surgery

    Science.gov (United States)

    Lee, Chang-Youn; Jang, Chang-Su; Kim, Ju-Won; Kim, Jwa-Young

    2013-01-01

    Objective The purpose of this study was to evaluate displacement of the mandibular condyle after orthognathic surgery using a condylar-repositioning device. Methods The patient group comprised 20 adults who underwent bimaxillary surgery between August 2008 and July 2011. The degree of condylar displacement was measured by pre- and postoperative tomographic analysis using centric relation bite and a wire during surgery. A survey assessing temporomandibular joint (TMJ) sound, pain, and locking was performed. The 20 tomographs and surveys were analyzed using the Wilcoxon signed-rank test and McNemar's test, respectively. Results No significant changes were observed in the anterior, superior, or posterior joint space of the TMJ (p > 0.05). In addition, no significant change was observed in TMJ sound (p > 0.05). However, TMJ pain and locking both decreased significantly after surgery (p < 0.05). Conclusions Due to its simplicity, this method may be feasible and useful for repositioning condyles. PMID:23671832

  20. Repositioning job fair of career opportunities – Career DAYS

    OpenAIRE

    Vodák, Ondřej

    2015-01-01

    This bachelor's thesis maps the change of prestigious job fair Career DAYS into an informal festival. For the process of change it uses various analysis of the consumer's perceptions which are used as basics for the product differentiation and positioning strategy. Opinions about the subject were gathered from professionals such as Kotler and Trout. This work examines the process from segmentation to targeting and differentiation of marketing offer with the branding and repositioning. The goa...

  1. 基于支持向量机MPLS的间歇过程故障诊断方法%On-line Fault Detection Using SVM-based Dynamic MPLS for Batch Processes

    Institute of Scientific and Technical Information of China (English)

    李运锋; 汪志锋; 袁景淇

    2006-01-01

    In this article, a nonlinear dynamic multiway partial least squares (MPLS) based on support vector machines (SVM) is developed for on-line fault detection in batch processes. The approach, referred to as SVM-based DMPLS, integrates the SVM with the MPLS model. Process data from normal historical batches are used to develop the MPLS model, and a series of single-input-single-output SVM networks are adopted to approximate nonlinear inner relationship between input and output variables. In addition, the application of a time-lagged window technique not only makes the complementarities of unmeasured data of the monitored batch unnecessary, but also significantly reduces the computation and storage requirements in comparison with the traditional MPLS. The proposed approach is validated by a simulation study of on-line fault detection for a fed-batch penicillin production.

  2. Repositioning through Culture: Testing Change in Connectivity Patterns

    Directory of Open Access Journals (Sweden)

    Beatriz Plaza

    2016-12-01

    Full Text Available Symbolic knowledge-driven innovations can play an important role in the economic development of cities and regions. Cultural events and infrastructures can act as powerful connectivity engines, generating new connections, rewiring links, and repositioning institutions/cities/regions on the Internet map. Within this framework, this paper aims to contribute to the analytical understanding of culture-led repositioning. For this purpose we perform regression analysis with cultural networks (observational cross-sectional network data from digital media for a specific cultural case study: the Basque Culinary Center (BCC, a higher education faculty of haute cuisine promoted by the University of Mondragon along with a group of Michelin-starred chefs. Results show that a cultural sector, such as haute cuisine, can contribute to structural changes in connectivity patterns, putting an institution/city/region on the media map. It is the connection (in the online press of the BCC to the influential Michelin-starred chefs that can fuel the accumulation of press articles (media items on the BCC; and it is precisely this accumulation of press articles that can impact BCC revenues. Put differently, the co-branding between the influential Michelin chefs and the BCC may have put the BCC on the press map, promoting new student registrations and fostering Basque haute cuisine. The main contribution of this article is a prototype of regression analysis to test repositioning with network data.

  3. An analysis of Taguchi's on-line quality monitoring procedure for variables based on the results of a sequence of inspections

    Directory of Open Access Journals (Sweden)

    Linda Lee Ho

    2012-04-01

    Full Text Available In this paper, a procedure for the on-line process control of variables is proposed. This procedure consists of inspecting the m-th item from every m produced items and deciding, at each inspection, whether the process is out-of-control. Two sets of limits, warning (µ0 ± W and control (µ0 ± C, are used. If the value of the monitored statistic falls beyond the control limits or if a sequence of h observations falls between the warning limits and the control limits, the production is stopped for adjustment; otherwise, production goes on. The properties of an ergodic Markov chain are used to obtain an expression for the average cost per item. The parameters (the sampling interval m, the widths of the warning, the control limits W and C(W < C, and the sequence length (h are optimized by minimizing the cost function. A numerical example illustrates the proposed procedure.

  4. ON-LINE MONITORING OF BIOMASS CONCENTRATION BASED ON A CAPACITANCE SENSOR: ASSESSING THE METHODOLOGY FOR DIFFERENT BACTERIA AND YEAST HIGH CELL DENSITY FED-BATCH CULTURES

    Directory of Open Access Journals (Sweden)

    A. C. L. Horta

    2015-12-01

    Full Text Available Abstract The performance of an in-situ capacitance sensor for on-line monitoring of biomass concentration was evaluated for some of the most important microorganisms in the biotechnology industry: Escherichia coli, Saccharomyces cerevisiae, Pichia pastoris and Bacillus megaterium. A total of 33 batch and fed-batch cultures were carried out in a bench-scale bioreactor and biomass formation trends were followed by dielectric measurements during the growth phase as well as the induction phase, for 5 recombinant E. coli strains. Permittivity measurements and viable cellular concentrations presented a linear correlation for all the studied conditions. In addition, the permittivity signal was further used for inference of the cellular growth rate. The estimated specific growth rates mirrored the main trends of the metabolic states of the different cells and they can be further used for setting-up control strategies in fed-batch cultures.

  5. On-line Over-voltage Detector Based on LabVIEW%基于LabVIEW的过电压在线检测仪

    Institute of Scientific and Technical Information of China (English)

    程刚; 王肖剑

    2012-01-01

    过电压在线检测仪主要用于变电站过电压在线检测,能自动追踪、并以较高的采样速率和采样深度记录内外过电压的波形、幅值及相关信息,并可查询已保存的过电压历史数据,同时实现对波形的多种操作;过电压在线检测仪采用电容分压器和NI公司的图形化编程软件LabVIEW等组成;经过运行证明该装置运行正常、稳定、可靠,能在过电压发生时完整、准确地同时记录下六路瞬态过电压信号,为更好的绝缘配合、修订绝缘水平提供有力参考.%On-Line over-voltage detector is mainly used for detection over -voltage of substation, automatic tracking, with higher sampling rate and sampling depth of the wave, both inside and outside record over voltage amplitude and related information, and inquires the historical overvoltage data, to realize the varied waveform operation. On-line over-voltage detector composed by capacitive divider and NI's Lab VIEW graphical programming software etc. The device run normally, stable and reliable, it can accurate record six channel transient overvoltage signals at the same time, it provide powerful reference for better insulation coordination and revise insulation level.

  6. Clean Air OnLine

    Energy Technology Data Exchange (ETDEWEB)

    Finney, D. [Environment Canada, Gatineau, PQ (Canada). Air Pollution Prevention Directorate

    2004-04-07

    This presentation describes Clean Air OnLine, a multi-tiered website dedicated to providing Canadians with information on air quality. The website is under development to support action to reduce air emissions, demonstrate the links between air emissions and environmental impacts, and enhance the understanding of sustainable community development issues such as health, energy, and urban sprawl. Partners in the Clean Air OnLine (CAOL) initiative include Environment Canada and the Clean Air Partnership which includes the Greater Toronto Area pilot project. The audience for CAOL includes municipal decision makers, local decision makers, community leaders, and the general public. The project provides Canadians with air pollution contextual information on pollution sources, pollutants, and related issues. It also provides information on health, environmental and economic impacts and the interrelationships with climate change issues and energy use. tabs., figs.

  7. On-line moisture analysis

    CERN Document Server

    Cutmore, N G

    2002-01-01

    Measurement of the moisture content of iron ore has become a key issue for controlling moisture additions for dust suppression. In most cases moisture content is still determined by manual or automatic sampling of the ore stream, followed by conventional laboratory analysis by oven drying. Although this procedure enables the moisture content to be routinely monitored, it is too slow for control purposes. This has generated renewed interest in on-line techniques for the accurate and rapid measurement of moisture in iron ore on conveyors. Microwave transmission techniques have emerged over the past 40 years as the dominant technology for on-line measurement of moisture in bulk materials, including iron ores. Alternative technologies have their limitations. Infra-red analysers are used in a variety of process industries, but rely on the measurement of absorption by moisture in a very thin surface layer. Consequently such probes may be compromised by particle size effects and biased presentation of the bulk mater...

  8. Horizontal canal paroxysmal positional vertigo (HCPPV) vs classical BPPV (new concepts about mechanism and domiciliary repositioning of particles)

    OpenAIRE

    Ghosh, P.

    2002-01-01

    Some new modificutiont of existing diagnostic and therapeutic manoeuvres (repositioning of particles) have been proposed, basing an the applications of the principles of hydrodynamics, inertial and gravitational forces in the semicircular canals. The above has been tried successfully on patients with benign paroxysmal positional vertigo (BPPV) and horizontal eanal paroxysmal positional vertigo (HCPPV) which can be executed by the patients themselves at home without the kelp of a therapist.

  9. The DYD-RCT protocol: an on-line randomised controlled trial of an interactive computer-based intervention compared with a standard information website to reduce alcohol consumption among hazardous drinkers

    Directory of Open Access Journals (Sweden)

    Godfrey Christine

    2007-10-01

    Full Text Available Abstract Background Excessive alcohol consumption is a significant public health problem throughout the world. Although there are a range of effective interventions to help heavy drinkers reduce their alcohol consumption, these have little proven population-level impact. Researchers internationally are looking at the potential of Internet interventions in this area. Methods/Design In a two-arm randomised controlled trial, an on-line psychologically enhanced interactive computer-based intervention is compared with a flat, text-based information web-site. Recruitment, consent, randomisation and data collection are all on-line. The primary outcome is total past-week alcohol consumption; secondary outcomes include hazardous or harmful drinking, dependence, harm caused by alcohol, and mental health. A health economic analysis is included. Discussion This trial will provide information on the effectiveness and cost-effectiveness of an on-line intervention to help heavy drinkers drink less. Trial registration International Standard Randomised Controlled Trial Number Register ISRCTN31070347

  10. Educational On-Line Gaming Propensity

    DEFF Research Database (Denmark)

    Sudzina, Frantisek; Razmerita, Liana; Kirchner, Kathrin

    2014-01-01

    Educational on-line games are promising for new generations of students who are grown up digital. Th e new generations of students are technology savvy and spend lots of time on the web and on social networks. Based on an exploratory study, this article investigates the factors that infl uence...... students’ willingness to participate in serious games for teaching/learning. Th is study investigates the relationship between students’ behavior on Facebook, Facebook games, and their attitude toward educational on-line games. Th e results of the study reveal that the early adopters of educational games...... are likely to be students, who are young, have only a few Facebook connections, who currently play Facebook game(s). Furthermore, the study emphasizes that there may be differences between students coming from various countries....

  11. Effects of kinesiology taping on repositioning error of the knee joint after quadriceps muscle fatigue.

    Science.gov (United States)

    Han, Jin Tae; Lee, Jung-Hoon

    2014-06-01

    [Purpose] The purpose of this study was to identify the effects of kinesiology taping on repositioning error of the knee joint after quadriceps muscle fatigue. [Subjects] Thirty healthy adults with no orthopaedic or neurological problems participated in this study. [Methods] The repositioning error of the knee joint was measured using a digital goniometer when the subjects extended their dominant-side knee to a random target angle (30°, 45°, or 60°) with their eyes closed, before and after a quadriceps muscle fatigue protocol, and after application of kinesiology tape. [Results] We found that repositioning errors of the dominant-side knee joint increased after quadriceps fatigue compared with no-fatigue conditions. However, kinesiology taping of the quadriceps muscle and patella after quadriceps fatigue significantly decreased repositioning errors of the knee joint. [Conclusion] These results suggest that quadriceps fatigue increases the repositioning error of the knee joint, whereas application of kinesiology tape decreases fatigue-induced joint repositioning error.

  12. An accurate bimaxillary repositioning technique using straight locking miniplates for the mandible-first approach in bimaxillary orthognathic surgery.

    Science.gov (United States)

    Iwai, Toshinori; Omura, Susumu; Honda, Koji; Yamashita, Yosuke; Shibutani, Naoki; Fujita, Koichi; Takasu, Hikaru; Murata, Shogo; Tohnai, Iwai

    2017-01-01

    Bimaxillary orthognathic surgery has been widely performed to achieve optimal functional and esthetic outcomes in patients with dentofacial deformity. Although Le Fort I osteotomy is generally performed before bilateral sagittal split osteotomy (BSSO) in the surgery, in several situations BSSO should be performed first. However, it is very difficult during bimaxillary orthognathic surgery to maintain an accurate centric relation of the condyle and decide the ideal vertical dimension from the skull base to the mandible. We have previously applied a straight locking miniplate (SLM) technique that permits accurate superior maxillary repositioning without the need for intraoperative measurements in bimaxillary orthognathic surgery. Here we describe the application of this technique for accurate bimaxillary repositioning in a mandible-first approach where the SLMs also serve as a condylar positioning device in bimaxillary orthognathic surgery.

  13. On Line Validation Exercise (OLIVE: A Web Based Service for the Validation of Medium Resolution Land Products. Application to FAPAR Products

    Directory of Open Access Journals (Sweden)

    Marie Weiss

    2014-05-01

    Full Text Available The OLIVE (On Line Interactive Validation Exercise platform is dedicated to the validation of global biophysical products such as LAI (Leaf Area Index and FAPAR (Fraction of Absorbed Photosynthetically Active Radiation. It was developed under the framework of the CEOS (Committee on Earth Observation Satellites Land Product Validation (LPV sub-group. OLIVE has three main objectives: (i to provide a consistent and centralized information on the definition of the biophysical variables, as well as a description of the main available products and their performances (ii to provide transparency and traceability by an online validation procedure compliant with the CEOS LPV and QA4EO (Quality Assurance for Earth Observation recommendations (iii and finally, to provide a tool to benchmark new products, update product validation results and host new ground measurement sites for accuracy assessment. The functionalities and algorithms of OLIVE are described to provide full transparency of its procedures to the community. The validation process and typical results are illustrated for three FAPAR products: GEOV1 (VEGETATION sensor, MGVIo (MERIS sensor and MODIS collection 5 FPAR. OLIVE is available on the European Space Agency CAL/VAL portal, including full documentation, validation exercise results, and product extracts.

  14. On Enterprise On-line Rendering an Account Based on WEB%基于WEB的企业网上报账系统的研究

    Institute of Scientific and Technical Information of China (English)

    游辉映

    2012-01-01

      当前企业“报账难”问题日显突显。如何创新财务报账方式,提高服务效率,提升财务管理水平,不断满足企业员工对财务报账的需求,提升企业财务服务价值,成为企业亟须解决的问题。文章通过调研企业财务报账模式,对企业网上报账体系的构建进行了研究和探讨,并提出应注意的问题。%  At present, enterprises have the difficulty in rendering an account. How to innovate in means of rendering an account, to improve service efficiency, to financial management, to satisfy staff's demand for rendering an account and to promote financial service value have become issues need to be solved. Through the study of rendering an account in enter-prises, the paper discusses the building of enterprise on-line rendering an account system and points out problems deserv-ing attention.

  15. Monitoring of potential cytotoxic and inhibitory effects of titanium dioxide using on-line and non-invasive cell-based impedance spectroscopy.

    Science.gov (United States)

    Male, Keith B; Hamzeh, Mahsa; Montes, Johnny; Leung, Alfred C W; Luong, John H T

    2013-05-13

    Titanium dioxide (TiO2) nanoparticles (NPs) with different sizes and structures were probed for plausible cytotoxicity using electric cell-substrate impedance sensing (ECIS), a non-invasive and on-line procedure for continuous monitoring of cytotoxicity. For insect cells (Spodoptera frugiperda Sf9), the ECIS50 values, i.e., the concentration required to achieve 50% inhibition of the response, differed depending on the size and shape of the TiO2 nanostructure. The lowest ECIS50 value (158 ppm) was observed for the needle shaped rutile TiO2 (10 nm×40 nm, 15.5 nm nominal particle size), followed by 211 ppm for P-25 (34.1 nm, 80% anatase and 20% rutile), 302 ppm for MTI5 (5.9 nm, 99% anatase) and 417 ppm for Hombitan LW-S bulk TiO2 (169.5 nm, 99% anatase). Exposure of TiO2 NPs to UV light at 254 nm or 365 nm exhibited no significant effect on the ECIS50 value due to the aggregation of TiO2 NPs with diminishing photocatalytic activities. Chinese hamster lung fibroblast V79 cells, exhibited no significant cytotoxicity/inhibition up to 400 ppm with P25, MTI5 and bulk TiO2. However, a noticeable inhibitory effect was observed (ECIS50 value of 251 ppm) with rutile TiO2 as cell spreading on the electrode surface was prevented.

  16. The Genomes OnLine Database (GOLD) v.5: a metadata management system based on a four level (meta)genome project classification.

    Science.gov (United States)

    Reddy, T B K; Thomas, Alex D; Stamatis, Dimitri; Bertsch, Jon; Isbandi, Michelle; Jansson, Jakob; Mallajosyula, Jyothi; Pagani, Ioanna; Lobos, Elizabeth A; Kyrpides, Nikos C

    2015-01-01

    The Genomes OnLine Database (GOLD; http://www.genomesonline.org) is a comprehensive online resource to catalog and monitor genetic studies worldwide. GOLD provides up-to-date status on complete and ongoing sequencing projects along with a broad array of curated metadata. Here we report version 5 (v.5) of the database. The newly designed database schema and web user interface supports several new features including the implementation of a four level (meta)genome project classification system and a simplified intuitive web interface to access reports and launch search tools. The database currently hosts information for about 19,200 studies, 56,000 Biosamples, 56,000 sequencing projects and 39,400 analysis projects. More than just a catalog of worldwide genome projects, GOLD is a manually curated, quality-controlled metadata warehouse. The problems encountered in integrating disparate and varying quality data into GOLD are briefly highlighted. GOLD fully supports and follows the Genomic Standards Consortium (GSC) Minimum Information standards.

  17. The Genomes OnLine Database (GOLD) v.5: a metadata management system based on a four level (meta)genome project classification

    Science.gov (United States)

    Reddy, T.B.K.; Thomas, Alex D.; Stamatis, Dimitri; Bertsch, Jon; Isbandi, Michelle; Jansson, Jakob; Mallajosyula, Jyothi; Pagani, Ioanna; Lobos, Elizabeth A.; Kyrpides, Nikos C.

    2015-01-01

    The Genomes OnLine Database (GOLD; http://www.genomesonline.org) is a comprehensive online resource to catalog and monitor genetic studies worldwide. GOLD provides up-to-date status on complete and ongoing sequencing projects along with a broad array of curated metadata. Here we report version 5 (v.5) of the database. The newly designed database schema and web user interface supports several new features including the implementation of a four level (meta)genome project classification system and a simplified intuitive web interface to access reports and launch search tools. The database currently hosts information for about 19 200 studies, 56 000 Biosamples, 56 000 sequencing projects and 39 400 analysis projects. More than just a catalog of worldwide genome projects, GOLD is a manually curated, quality-controlled metadata warehouse. The problems encountered in integrating disparate and varying quality data into GOLD are briefly highlighted. GOLD fully supports and follows the Genomic Standards Consortium (GSC) Minimum Information standards. PMID:25348402

  18. The Genomes OnLine Database (GOLD) v.5: a metadata management system based on a four level (meta)genome project classification

    Energy Technology Data Exchange (ETDEWEB)

    Reddy, Tatiparthi B. K. [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Thomas, Alex D. [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Stamatis, Dimitri [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Bertsch, Jon [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Isbandi, Michelle [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Jansson, Jakob [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Mallajosyula, Jyothi [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Pagani, Ioanna [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Lobos, Elizabeth A. [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); Kyrpides, Nikos C. [USDOE Joint Genome Institute (JGI), Walnut Creek, CA (United States); King Abdulaziz Univ., Jeddah (Saudi Arabia)

    2014-10-27

    The Genomes OnLine Database (GOLD; http://www.genomesonline.org) is a comprehensive online resource to catalog and monitor genetic studies worldwide. GOLD provides up-to-date status on complete and ongoing sequencing projects along with a broad array of curated metadata. Within this paper, we report version 5 (v.5) of the database. The newly designed database schema and web user interface supports several new features including the implementation of a four level (meta)genome project classification system and a simplified intuitive web interface to access reports and launch search tools. The database currently hosts information for about 19 200 studies, 56 000 Biosamples, 56 000 sequencing projects and 39 400 analysis projects. More than just a catalog of worldwide genome projects, GOLD is a manually curated, quality-controlled metadata warehouse. The problems encountered in integrating disparate and varying quality data into GOLD are briefly highlighted. Lastly, GOLD fully supports and follows the Genomic Standards Consortium (GSC) Minimum Information standards.

  19. Coordenadores de comunidades de repositórios institucionais: o caso do repositóriumCoordinators of institutional repositories communities: the repositórium case

    Directory of Open Access Journals (Sweden)

    Flávia Garcia Rosa

    2010-01-01

    Full Text Available O Movimento do Acesso Livre – Open Access Movement (OAM – foi estimulado por dois eventos importantes: a evolução das TIC, processo facilitador da disseminação e acessibilidade à informação, e os elevados custos das publicações científicas impressas, face a contextos de maiores constrangimentos financeiros da instituições de ensino superior e de investigação. Os Repositórios Institucionais (RI são um dos elementos fundamentais do OAM e encontram-se em processo de expansão. Este texto reporta-se a um estudo focado nos coordenadores de comunidades do repositório institucional da Universidade do Minho tendo por objectivos a identificação do perfil dos coordenadores e a identificação de práticas de estímulo ao depósito ao nível das diferentes comunidades. A metodologia de investigação adoptada consistiu num levantamento (survey através de um questionário online. Os dados recolhidos apontam para o reconhecimento, por parte dos coordenadores, das vantagens associadas ao depósito em RI, mas identificam também casos de desconhecimento do OAM e de baixo nível de auto-arquivamento por parte de alguns coordenadores de comunidades. São identificadas como principais iniciativas ao nível das políticas de estímulo ao depósito, por parte das várias comunidades, a “obrigatoriedade do depósito” e práticas de “apoio mediado”. A análise dos dados recolhidos conduziu-nos a um conjunto de reflexões que entendemos poderem ser aplicadas ao caso do RepositóriUM, mas também constituir uma orientação para outros RI em desenvolvimento.

  20. Modified Intraoral Repositioning Appliance in Complete Bilateral Cleft Lip and Palate

    OpenAIRE

    Raghav, Pradeep; Ahuja, NK; Gahlawat, Subhash

    2010-01-01

    Objective The purpose of the modified repositioning appliance was to overcome the shortcoming of existing design for repositioning protruded premaxilla in a child with bilateral cleft lip and palate. Methods The basic principles of design were similar to Latham’s appliance but the surgical pinning of premaxillary segment was avoided and instead acrylic splint was prepared. Conclusions This technique avoids any invasive procedure, is useful to reposition protruded premaxillary segment in bilat...

  1. Arthroscopic-Assisted Intraosseous Balloon-Assisted Repositioning of a Tibial Plateau Fracture: A Case Report.

    Science.gov (United States)

    Brinkmann, O; Rau, M; Maenz, S; Bungartz, M; Matziolis, G

    2015-01-01

    This is the first description of an arthroscopic-assisted intraosseous balloon-assisted repositioning and defect filling of a tibial plateau fracture. The bone defect was filled with calcium phosphate cement in a liquid/paste form. The described technique was therefore introduced in order to allow an arthroscopic control of reposition and intra-articular cement escape during defect filling. X-rays showed an exact reposition without cement escape and the clinical outcome was satisfactory.

  2. Nursing staff induced repositionings and immobile patients' spontaneous movements in nursing care.

    Science.gov (United States)

    Källman, Ulrika; Bergstrand, Sara; Ek, Anna-Christina; Engström, Maria; Lindgren, Margareta

    2016-12-01

    The aim of this study was to investigate nursing staff induced repositionings and the patients' spontaneous movements during the day and night among older immobile patients in nursing care. Furthermore, the aim was to identify factors associated with the nursing staff induced repositionings and the patients' spontaneous movement frequency. An observational cross-sectional design was used. Spontaneous movements among patients (n = 52) were registered continuously using the MovinSense monitoring system. The nursing staff documented each time they repositioned the patient. Patients spontaneous movements were compared with nursing staff induced repositionings. There were large variations in the patients' spontaneous repositioning frequency during both days and nights, which shows that, although immobilised, some patients frequently reposition themselves. Analgesics were positively related to the movement frequency and psycholeptics were negatively related. The nursing staff more often repositioned the patients who were assessed as high risk than those assessed as low risk, but the patients' spontaneous movement frequency was not correlated to the risk score. This may be important when planning repositioning schedules. A monitoring system may be useful in decision making with regard to planning repositioning and positions used in the prevention of pressure ulcers among elderly immobile patients.

  3. Frequent manual repositioning and incidence of pressure ulcers among bed-bound elderly hip fracture patients.

    Science.gov (United States)

    Rich, Shayna E; Margolis, David; Shardell, Michelle; Hawkes, William G; Miller, Ram R; Amr, Sania; Baumgarten, Mona

    2011-01-01

    Frequent manual repositioning is an established part of pressure ulcer prevention, but there is little evidence for its effectiveness. This study examined the association between repositioning and pressure ulcer incidence among bed-bound elderly hip fracture patients, using data from a 2004-2007 cohort study in nine Maryland and Pennsylvania hospitals. Eligible patients (n=269) were age ≥ 65 years, underwent hip fracture surgery, and were bed-bound at index study visits (during the first 5 days of hospitalization). Information about repositioning on the days of index visits was collected from patient charts; study nurses assessed presence of stage 2+ pressure ulcers 2 days later. The association between frequent manual repositioning and pressure ulcer incidence was estimated, adjusting for pressure ulcer risk factors using generalized estimating equations and weighted estimating equations. Patients were frequently repositioned (at least every 2 hours) on only 53% (187/354) of index visit days. New pressure ulcers developed at 12% of visits following frequent repositioning vs. 10% following less frequent repositioning; the incidence rate of pressure ulcers per person-day did not differ between the two groups (incidence rate ratio 1.1, 95% confidence interval 0.5-2.4). No association was found between frequent repositioning of bed-bound patients and lower pressure ulcer incidence, calling into question the allocation of resources for repositioning.

  4. PHENIX on-line systems

    Energy Technology Data Exchange (ETDEWEB)

    Adler, S.S.; Allen, M.; Alley, G.; Amirikas, R.; Arai, Y.; Awes, T.C.; Barish, K.N.; Barta, F.; Batsouli, S.; Belikov, S.; Bennett, M.J.; Bobrek, M.; Boissevain, J.G.; Boose, S.; Britton, C.; Britton, L.; Bryan, W.L.; Cafferty, M.M.; Carey, T.A.; Chang, W.C.; Chi, C.Y.; Chiu, M.; Cianciolo, V.; Cole, B.A.; Constantin, P.; Cook, K.C.; Cunitz, H.; Desmond, E.J.; Ebisu, K.; Efremenko, Y.V.; El Chenawi, K.; Emery, M.S.; Engo, D.; Ericson, N.; Fields, D.E.; Frank, S.; Frantz, J.E.; Franz, A.; Frawley, A.D.; Fried, J.; Gannon, J.; Gee, T.F.; Gentry, R.; Giannotti, P.; Gustafsson, H.-A.; Haggerty, J.S.; Hahn, S.; Halliwell, J.; Hamagaki, H.; Hansen, A.G.; Hara, H.; Harder, J.; He, X.; Heistermann, F.; Hemmick, T.K.; Hibino, M.; Hill, J.C. E-mail: jhill@iastate.edu; Homma, K.; Jacak, B.V.; Jagadish, U.; Jia, J.; Kajihara, F.; Kametani, S.; Kamyshkov, Y.; Kandasamy, A.; Kang, J.H.; Kapustinsky, J.; Katou, K.; Kelley, M.A.; Kelly, S.; Kikuchi, J.; Kim, S.Y.; Kim, Y.G.; Kistenev, E.; Kotchetkov, D.; Kurita, K.; Lajoie, J.G.; Lenz, M.; Lenz, W.; Li, X.H.; Lin, S.; Liu, M.X.; Markacs, S.; Matathias, F.; Matsumoto, T.; Mead, J.; Mischke, R.E.; Mishra, G.C.; Moore, A.; Muniruzzamann, M.; Musrock, M.; Nagle, J.L.; Nandi, B.K.; Newby, J.; Nystrand, J.; O' Brien, E.; O' Connor, P.; Ohnishi, H.; Oskarsson, A.; Osterman, L.; Oyama, K.; Paffrath, L.; Pancake, C.E.; Pantuev, V.S.; Petridis, A.N.; Pisani, R.P.; Plagge, T.; Plasil, F.; Purschke, M.L.; Rankowitz, S.; Rao, R.; Rau, M.; Read, K.F.; Ryu, S.S.; Sakaguchi, T.; Sato, H.D.; Seto, R.; Shiina, T.; Silvermyr, D.; Simon-Gillo, J.; Simpson, M.; Sippach, W.; Skank, H.D.; Skutnik, S.; Sleege, G.A.; Smith, G.D.; Smith, M.; Stankus, P.W.; Steinberg, P.; Sugitate, T.; Sullivan, J.P.; Taketani, A.; Tamai, M.; Tanaka, Y.; Thomas, W.D.; Todd, R.; Toldo, F.; Turner, G.; Ushiroda, T.; Velkovska, J.; Hecke, H.W. van; Lith, M. van; Villatte, L.; Achen, W. von; Walker, J.W.; Wang, H.Q.; White, S.N.; Wintenberg, A.L.; Witzig, C.; Wood, L.[and others

    2003-03-01

    The PHENIX On-Line system takes signals from the Front End Modules (FEM) on each detector subsystem for the purpose of generating events for physics analysis. Processing of event data begins when the Data Collection Modules (DCM) receive data via fiber-optic links from the FEMs. The DCMs format and zero suppress the data and generate data packets. These packets go to the Event Builders (EvB) that assemble the events in final form. The Level-1 trigger (LVL1) generates a decision for each beam crossing and eliminates uninteresting events. The FEMs carry out all detector processing of the data so that it is delivered to the DCMs using a standard format. The FEMs also provide buffering for LVL1 trigger processing and DCM data collection. This is carried out using an architecture that is pipelined and deadtimeless. All of this is controlled by the Master Timing System (MTS) that distributes the RHIC clocks. A Level-2 trigger (LVL2) gives additional discrimination. A description of the components and operation of the PHENIX On-Line system is given and the solution to a number of electronic infrastructure problems are discussed.

  5. Repositioning of malpositioned or flipped central venous catheters

    Energy Technology Data Exchange (ETDEWEB)

    Thalhammer, A.; Jacobi, V.; Balzer, J.; Vogl, T.J. [Institute for Diagnostic and Interventional Radiology, Central Radiology Clinic, J.W. Goethe University, Frankfurt am Main (Germany)

    2002-03-01

    Primary misplaced or secondary flipped implanted catheters are located mostly in the right jugular vein. We demonstrate an effective method to replace fix implanted catheters such as Ports, Grochomg or Hickman catheters. Using a femoral venous approach, replacement into the superior vena cava can easily be done with a Sidewinder 1 catheter which is hooked over the misplaced central venous approach. In all our patients the method was successful. The repositioning technique described is simple, fast and has low costs. We can keep sterile conditions and do not need to solve the catheters' fixation. (orig.)

  6. Solving the Liner Shipping Fleet Repositioning Problem with Cargo Flows

    DEFF Research Database (Denmark)

    Tierney, Kevin; Askelsdottir, Björg; Jensen, Rune Møller;

    2015-01-01

    to reposition vessels as cheaply as possible without disrupting cargo flows. The LSFRP is characterized by chains of interacting activities with a multicommodity flow over paths defined by the activities chosen. Despite its industrial importance, the LSFRP has received little attention in the literature. We...... introduce a novel mathematical model and a simulated annealing algorithm for the LSFRP with cargo flows that makes use of a carefully constructed graph; we evaluate these approaches using real-world data from our industrial collaborator. Additionally, we compare the performance of our approach against...

  7. SU-E-T-496: Influence of the Intrafraction Patient Repositioning On Spot Scanning Proton Therapy for Prostate Cancer

    Energy Technology Data Exchange (ETDEWEB)

    Fujii, Y; Yamada, T [Hokkaido University Hospital, Sapporo, Hokkaido (Japan); Hitachi Ltd., Hitachi-shi, Ibaraki (Japan); Matsuura, T; Takao, S; Matsuzaki, Y; Miyamoto, N [Hokkaido University Hospital, Sapporo, Hokkaido (Japan); Shimizu, S; Shirato, H [Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido (Japan); Umegaki, K [Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido (Japan)

    2015-06-15

    Purpose To verify the effect of intrafraction patient repositioning based on real time image guidance on the proton dose distribution for prostate cancer. Methods Dose distributions were simulated using CT images of prostate cancer patients. Treatment plans were prepared using proton beam from left side of the patient with 3 and 6 mm lateral margins. During the beam delivery, prostate position was assumed to be shifted by 5 mm in anterior, posterior, superior and inferior directions. The dose distributions were calculated for two scenarios; (i) the patient position was readjusted by 5 mm just after the prostate shift occurs (ii) the patient position was not adjusted. Such a real time readjustment can be realized with real time image guidance. The differences of the values D{sub 5} and D{sub 95} in CTV (D{sub 5–95}) were compared between different sizes of the lateral margins and different scenarios. Results D{sub 5–95} values in the case of scenario (i) are smaller than scenario (ii). The differences between scenario (i) and (ii) were not depend on the directions of the prostate shift. In the case of scenario (ii), margin expansion makes D{sub 5–95} values small. In the case of scenario (i), margin size is uncorrelated to D{sub 5–95} values. Conclusion These results indicate that the intrafraction patient repositioning is effective to minimize dose deterioration when the prostate moves during the irradiation. In the case without intrafraction patient repositioning, margin expansion is effective to reduce dose deterioration. In the case with intrafraction patient repositioning, 3 mm margin is enough to minimize dose deterioration.

  8. Research on on line monitoring and condition based maintenance technology of power primary equipment%电力一次设备的在线监测及其状态检修技术的研究

    Institute of Scientific and Technical Information of China (English)

    金兴武

    2016-01-01

    In this paper,the on-line monitoring and condition based maintenance technology of power primary equipment are studied,hoping that this research can promote the development of China's electric power industry to a certain extent.%本文就电力一次设备的在线监测及其状态检修技术进行了具体研究,希望这一研究能够在一定程度上推动我国电力事业的相关发展.

  9. Coupling on-line preconcentration by ion-exchange with ETAAS. A novel flow injection approach based on the use of a renewable microcolumn as demonstrated for the determination of nickel in environmental and biological samples

    DEFF Research Database (Denmark)

    Wang, Jianhua; Hansen, Elo Harald

    2000-01-01

    A novel way of exploiting flow injection/sequential injection (FIA/SIA) on-line ion-exchange preconcentration with detection by electrothermal atomic absorption spectrometry (ETAAS) is described and demonstrated for the determination of trace-levels of nickel. Based on the use of a renewable...... microcolumn incorporated within an integrated micro FI-system, the column is loaded with a defined volume of small beads of an SP Sephadex C-25 cation-exchange resin and subsequently exposed to a metered amount of sample solution. However, instead of eluting the retained analyte from the organic ion-exchange...

  10. On-line characterization of a hybridoma cell culture process.

    Science.gov (United States)

    Zhou, W; Hu, W S

    1994-06-20

    The on-line determination of the physiological state of a cell culture process requires reliable on-line measurements of various parameters and calculations of specific rates from these measurements. The cell concentration of a hybridoma culture was estimated on-line by measuring optical density (OD) with a laser turbidity probe. The oxygen uptake rate (OUR) was determined by monitoring dynamically dissolved oxygen concentration profiles and closing oxygen balances in the culture. The base addition for neutralizing lactate produced by cells was also monitored on-line via a balance. Using OD and OUR measurements, the specific growth and specific oxygen consumption rates were determined on-line. By combining predetermined stoichiometric relationships among oxygen and glucose consumption and lactate production, the specific glucose consumption and lactate production rates were also calculated on-line. Using these on-line measurements and calculations, the hybridoma culture process was characterized on-line by identifying the physiological states. They will also facilitate the implementation of nutrient feeding strategies for fed-batch and perfusion cultures. (c) 1994 John Wiley & Sons, Inc.

  11. Canalith Repositioning Variations for Benign Paroxysmal Positional Vertigo

    Science.gov (United States)

    Cohen, Helen S.; Sangi-Haghpeykar, Haleh

    2010-01-01

    Objective To determine if variations in common treatments for benign paroxysmal positional vertigo (BPPV) affected efficacy. Study Design Prospective, pseudo-randomized study. Setting Out-patient practice in a tertiary care facility Subjects and Methods Patients (n=118) with unilateral BPPV of the posterior canal, including 13 patients with BPPV of the lateral canal were tested at a tertiary care center on one of five interventions: canalith repositioning maneuver (CRP), CRP plus home exercise, modified CRP, CRP for patients with involvement of two semicircular canals, self-CRP home exercise. Self-CRP was also compared to previously published data on efficacy of the Brandt Daroff exercise. Main outcome measures were vertigo intensity and frequency, presence/ absence of Dix-Hallpike responses, Vestibular Disorders Activities of Daily Living Scale (VADL), computerized dynamic posturography. Results Vertigo intensity and frequency and Dix-Hallpike responses decreased significantly and posturography and VADL improved significantly from pre- to post tests. No other significant changes were found. The groups did not differ significantly. Vertigo intensity and frequency were not strongly related at pre-test but were related at post-test. Length of illness and age did not influence the results. Conclusions However the head is moved, as long as it is moved rapidly enough and through the correct planes in space repositioning treatments are likely to be effective. Therefore clinicians have a range of choices in selecting the treatment best suited for each patient’s unique needs. PMID:20723779

  12. Effects of wearing ankle weight on knee joint repositioning sense in the elderly.

    Science.gov (United States)

    Kim, Sooyoung; Jung, Daeun; Han, Jintae; Jung, Jaemin

    2016-09-01

    [Purpose] To investigate the effects of different ankle weights on knee joint repositioning sense in elderly individuals. [Subjects and Methods] Twenty-one subjects were divided for assessment as follows: young (20-30 years, n=10) and elderly (60-70 years, n=11). Knee joint repositioning error was measured by asking the subjects to reposition the target angle of their knee joints while wearing different ankle weights (0%, 0.5%, 1%, and 1.5%) in an open kinetic chain. The Hawk Digital System (60 Hz; Motion Analysis, Santa Rosa, CA, USA) was used to measure knee joint repositioning error. Differences in knee joint repositioning error between the young and elderly groups according to ankle weight load were examined by using two-way mixed repeated-measures analysis of variance. [Results] The knee joint repositioning error was lower with than without ankle weights in both groups. The error value was lowest with the 1.0% weight, though not significantly. Knee joint repositioning error was significantly higher in the elderly under all the ankle weight conditions. [Conclusion] Knee joint repositioning sense can be improved in elderly individuals by wearing proper ankle weights. However, weights that are too heavy might disturb knee joint positioning sense.

  13. Acceptability of self-conducted home-based HIV testing among men who have sex with men in Brazil: data from an on-line survey.

    Science.gov (United States)

    Lippman, Sheri A; Périssé, André R S; Veloso, Valdiléa G; Sullivan, Patrick S; Buchbinder, Susan; Sineath, R Craig; Grinsztejn, Beatriz

    2014-04-01

    The Brazilian HIV/AIDS epidemic is concentrated among men who have sex with men (MSM), however HIV testing rates among MSM are not commensurate with their risk. Strategies to expand early diagnosis may include use of self-conducted home-based testing kits, which are now available for purchase in the US. In April 2011 we conducted a survey with Brazilian MSM using Facebook to assess HIV testing preferences and acceptability of home-based testing. Among 356 previously tested, HIV-negative MSM, 47% reported a preference for home-based testing, 27% preferred clinic-based testing, and 26% had no preference. Less frequent testers and those who had considered testing but failed to test were more likely to prefer home-based testing. Close to 90% reported that they would use self-test kits; 62% and 54% said they would use home-based testing to make choices about unprotected sex with regular and new partners, respectively. Concerns included difficulty to understand the tests (32%) and receiving results alone (23%). Overall, home-based testing may appeal to MSM and result in increased testing frequency. Research on feasibility and utilization of self-tests in practice is needed.

  14. Acceptability of self-conducted home-based HIV testing among men who have sex with men in Brazil: data from an on-line survey

    Directory of Open Access Journals (Sweden)

    Sheri A. Lippman

    2014-04-01

    Full Text Available The Brazilian HIV/AIDS epidemic is concentrated among men who have sex with men (MSM, however HIV testing rates among MSM are not commensurate with their risk. Strategies to expand early diagnosis may include use of self-conducted home-based testing kits, which are now available for purchase in the US. In April 2011 we conducted a survey with Brazilian MSM using Facebook to assess HIV testing preferences and acceptability of home-based testing. Among 356 previously tested, HIV-negative MSM, 47% reported a preference for home-based testing, 27% preferred clinic-based testing, and 26% had no preference. Less frequent testers and those who had considered testing but failed to test were more likely to prefer home-based testing. Close to 90% reported that they would use self-test kits; 62% and 54% said they would use home-based testing to make choices about unprotected sex with regular and new partners, respectively. Concerns included difficulty to understand the tests (32% and receiving results alone (23%. Overall, home-based testing may appeal to MSM and result in increased testing frequency. Research on feasibility and utilization of self-tests in practice is needed.

  15. Directions for Future Research in On-line Distance Education

    OpenAIRE

    Alaa SADIK

    2015-01-01

    Although institutions have invested much in developing on-line environments or using already established commercial platforms, only few studies have been conducted to investigate the effectiveness of on-line courses based on empirical data (Jung and Rha, 2000). A review of the literature conducted in this study showed that most of online learning studies investigated the effectiveness of Web-based interaction or Internet conferencing on learning, not the entire learning environment. Even in t...

  16. Evolving factor analysis-based method for correcting monitoring delay in different batch runs for use with PLS: On-line monitoring of a transesterification reaction by ATR-FTIR.

    Science.gov (United States)

    Trevisan, Marcello G; Garcia, Camila M; Schuchardt, Ulf; Poppi, Ronei J

    2008-01-15

    In this work, the base-catalyzed transesterification of soybean oil with ethanol was monitored on-line using mid-infrared spectroscopy (MIRS) and the yield of fatty acid ethyl esters (biodiesel) was obtained by (1)H NMR spectroscopy. The MIRS monitoring carried out for 12min, was performed using a cylindrical internal reflectance cell of PbSe in the range of 3707-814cm(-1) with eight co-added scans. Two different data treatment strategies were used: in the first, the models were built using the raw data and in the other, evolving factor analysis (EFA) was used to overcome the sensor time delay due to the on-line analysis, producing significantly better results. In addition, models based on partial least squares (PLS) using three batches for calibration and another for validation were compared with models with just one batch for calibration and three for validation. The models were compared between each other using root mean square error of prediction (RMSEP) and root mean square prediction difference (RMSPD), obtaining relative errors under 3%.

  17. Development and validation of a strategic repositioning model for defense and aerospace contractors

    Science.gov (United States)

    Bers, John A.

    Strategic repositioning refers to the organized efforts of defense contractors to "reposition" a technology that they have developed for a defense sector customer into a civilian or commercial market. The strategic repositioning model developed here is a structural model: it seeks to isolate the factors that influence choice of strategy, which in turn influences the organization's performance. The model draws from the prior experience of contractors (through interviews and surveys) and companies in other sectors (through a review of the relevant published research). (1) Over all, the model accounted for 55% of the variance in financial performance of the sample and 35% for the underlying population. (2) Key success factors include a rigorous planning process, a target market in the growth (vs. incubation) stage, a priority on market leadership as well as financial return, the ability to operate in an ambiguous business environment, and a relatively short time horizon but strong corporate support. (3) The greatest challenges that a contractor is likely to encounter are understanding his new customers' buying practices, strong competition, and adapting his technology to their needs and price expectations. (4) To address these issues contractors often involve partners in their entry strategy, but partnerships of equals tend to be more difficult to bring off than direct entry strategies. (5) The two major target market categories--government and commercial--present different challenges. Commercial customers are more likely to resist doing business with the contractor, while contractors entering government and other noncommercial markets are more likely to encounter price resistance, low technical sophistication among customers, and difficulties reaching their customer base. (6) Despite these differences across markets, performance is not influenced by the target market category, nor by the type of product or service or the contractor's functional orientation (marketing

  18. Repositioning organohalogen drugs: a case study for identification of potent B-Raf V600E inhibitors via docking and bioassay

    Science.gov (United States)

    Li, Yisu; Guo, Binbin; Xu, Zhijian; Li, Bo; Cai, Tingting; Zhang, Xinben; Yu, Yuqi; Wang, Heyao; Shi, Jiye; Zhu, Weiliang

    2016-01-01

    Drug repositioning has been attracting increasingly attention for its advantages of reducing costs and risks. Statistics showed that around one quarter of the marketed drugs are organohalogens. However, no study has been reported, to the best of our knowledge, to aim at efficiently repositioning organohalogen drugs, which may be attributed to the lack of accurate halogen bonding scoring function. Here, we present a study to show that two organohalogen drugs were successfully repositioned as potent B-Raf V600E inhibitors via molecular docking with halogen bonding scoring function, namely D3DOCKxb developed in our lab, and bioassay. After virtual screening by D3DOCKxb against the database CMC (Comprehensive Medicinal Chemistry), 3 organohalogen drugs that were predicted to form strong halogen bonding with B-Raf V600E were purchased and tested with ELISA-based assay. In the end, 2 of them, rafoxanide and closantel, were identified as potent inhibitors with IC50 values of 0.07 μM and 1.90 μM, respectively, which are comparable to that of vemurafenib (IC50: 0.17 μM), a marketed drug targeting B-Raf V600E. Single point mutagenesis experiments confirmed the conformations predicted by D3DOCKxb. And comparison experiment revealed that halogen bonding scoring function is essential for repositioning those drugs with heavy halogen atoms in their molecular structures. PMID:27501852

  19. Influence of prolonged unilateral cervical muscle contraction on head repositioning--decreased overshoot after a 5-min static muscle contraction task.

    Science.gov (United States)

    Malmström, Eva-Maj; Karlberg, Mikael; Holmström, Eva; Fransson, Per-Anders; Hansson, Gert-Ake; Magnusson, Måns

    2010-06-01

    The ability to reproduce a specified head-on-trunk position can be an indirect test of cervical proprioception. This ability is affected in subjects with neck pain, but it is unclear whether and how much pain or continuous muscle contraction factors contribute to this effect. We studied the influence of a static unilateral neck muscle contraction task (5 min of lateral flexion at 30% of maximal voluntary contraction) on head repositioning ability in 20 subjects (10 women, 10 men; mean age 37 years) with healthy necks. Head repositioning ability was tested in the horizontal plane with 30 degrees target and neutral head position tests; head position was recorded by Zebris((R)), an ultrasound-based motion analyser. Head repositioning ability was analysed for accuracy (mean of signed differences between introduced and reproduced positions) and precision (standard deviation of the differences). Accuracy of head repositioning ability increased significantly after the muscle contraction task, as the normal overshoot was reduced. An average overshoot of 7.1 degrees decreased to 4.6 degrees after the muscle contraction task for the 30 degrees target and from 2.2 degrees to 1.4 degrees for neutral head position. The increased accuracy was most pronounced for movements directed towards the activated side. Hence, prolonged unilateral neck muscle contraction may increase the sensitivity of cervical proprioceptors.

  20. Improving the efficiencies of simultaneous organic substance and nitrogen removal in a multi-stage loop membrane bioreactor-based PWWTP using an on-line Knowledge-Based Expert System.

    Science.gov (United States)

    Chen, Zhao-Bo; Nie, Shu-Kai; Ren, Nan-Qi; Chen, Zhi-Qiang; Wang, Hong-Cheng; Cui, Min-Hua

    2011-10-15

    The results of the use of an expert system (ES) to control a novel multi-stage loop membrane bioreactor (MLMBR) for the simultaneous removal of organic substances and nutrients are reported. The study was conducted at a bench-scale plant for the purpose of meeting new discharge standards (GB21904-2008) for the treatment of chemical synthesis-based pharmaceutical wastewater (1200-9600 mg/L COD, 500-2500 mg/L BOD5, 50-200 mg/L NH4+-N and 105-400 mg/L TN in the influent water) by developing a distributed control system. The system allows various expert operational approaches to be deployed with the goal of minimizing organic substances and nitrogen levels in the outlet while using the minimum amount of energy. The proposed distributed control system, which is supervised by a Knowledge-Based Expert System (KBES) constructed with G2 (a tool for expert system development) and a back propagation BP artificial neural network, permits the on-line implementation of every operating strategy of the experimental system. A support vector machine (SVM) is applied to achieve pattern recognition. A set of experiments involving variable sludge retention time (SRT), hydraulic retention time (HRT) and dissolved oxygen (DO) was carried out. Using the proposed system, the amounts of COD, TN and NH4+-N in the effluent decreased by 55%, 62% and 38%, respectively, compared to the usual operating conditions. These improvements were achieved with little energy cost because the performance of the treatment plant was optimized using operating rules implemented in real time. Copyright © 2011 Elsevier Ltd. All rights reserved.

  1. Investigation of Line Current Harmonics in Cascaded Multi-level Inverter Based Induction Motor Drive and an Adaptive On-line Selective Current Harmonic Elimination Algorithm

    Directory of Open Access Journals (Sweden)

    P. Avirajamanjula

    2015-03-01

    Full Text Available Multilevel Inverters (MLIs have drawn increasing attention in numerous applications, especially in drives, distributed energy resources area, utility etc. MLIs have the ability to synthesize a near sinusoidal output voltage wave with minimal Total Harmonic Distortion (THD in low frequency switching. Even though they offer lower THD, the presence of lower order harmonics is objectionable and harmonics elimination in Multilevel Inverters (MLIs has been receiving immense attention for the past few decades. Existing Selective Harmonic Elimination (SHE techniques can eliminate the objectionable lower order voltage harmonics with low switching frequency by solving the Fourier non-linear transcendental equations of the output voltage. The line current harmonics has a direct role to play on the magneto-motive force and results in increase of mismatching of air-gap permeance, vibrations, acoustic noise etc. This study proposes Normalized Least Mean Squares (NLMS algorithm based scheme to eliminate the selected dominant harmonics in load current using only the knowledge of the frequencies to be eliminated. The algorithm is simulated using MATLAB/SIMULINK tool for a three-phase VSI to eliminate the fifth and seventh harmonics. The informative simulation results verify the validity and effectiveness of the proposed algorithm. The system performance is analyzed based on the simulation results considering Total Harmonic Distortion (THD, magnitude of eliminated harmonics and frequency spectrum.

  2. DNAdigest and Repositive: Connecting the World of Genomic Data.

    Science.gov (United States)

    Kovalevskaya, Nadezda V; Whicher, Charlotte; Richardson, Timothy D; Smith, Craig; Grajciarova, Jana; Cardama, Xocas; Moreira, José; Alexa, Adrian; McMurray, Amanda A; Nielsen, Fiona G G

    2016-03-01

    There is no unified place where genomics researchers can search through all available raw genomic data in a way similar to OMIM for genes or Uniprot for proteins. With the recent increase in the amount of genomic data that is being produced and the ever-growing promises of precision medicine, this is becoming more and more of a problem. DNAdigest is a charity working to promote efficient sharing of human genomic data to improve the outcome of genomic research and diagnostics for the benefit of patients. Repositive, a social enterprise spin-out of DNAdigest, is building an online platform that indexes genomic data stored in repositories and thus enables researchers to search for and access a range of human genomic data sources through a single, easy-to-use interface, free of charge.

  3. DNAdigest and Repositive: Connecting the World of Genomic Data.

    Directory of Open Access Journals (Sweden)

    Nadezda V Kovalevskaya

    2016-03-01

    Full Text Available There is no unified place where genomics researchers can search through all available raw genomic data in a way similar to OMIM for genes or Uniprot for proteins. With the recent increase in the amount of genomic data that is being produced and the ever-growing promises of precision medicine, this is becoming more and more of a problem. DNAdigest is a charity working to promote efficient sharing of human genomic data to improve the outcome of genomic research and diagnostics for the benefit of patients. Repositive, a social enterprise spin-out of DNAdigest, is building an online platform that indexes genomic data stored in repositories and thus enables researchers to search for and access a range of human genomic data sources through a single, easy-to-use interface, free of charge.

  4. Repositioning Skill Acquisition For The Transformation Of Nigerian Economy

    Directory of Open Access Journals (Sweden)

    Dr. Peter Ashlame Agu

    2015-08-01

    Full Text Available Since the past two decades or so the question of functionality of Nigerian educational products has been an issue of concern and a subject of discussion among educational analysts. This is against the backdrop that many students who graduate with admirable certificates from the nations reputable institutions are often unable to apply the acquired knowledge and skills to work situations. Contemporary societies all over the world require that preparation for work must become an integral part of a persons total educational experience. One reason for this requirement is to equip their citizenry with employable skills to enable them produce and use the goods and services which any society needs for its socio-economic growth. This paper therefore examines the role of skill acquisition in the transformation of Nigerian economy and proffers suggestions on how it can be repositioned to transform Nigerian education.

  5. Improvement of specific growth rate of Pichia pastoris for effective porcine interferon-α production with an on-line model-based glycerol feeding strategy.

    Science.gov (United States)

    Gao, Min-Jie; Zheng, Zhi-Yong; Wu, Jian-Rong; Dong, Shi-Juan; Li, Zhen; Jin, Hu; Zhan, Xiao-Bei; Lin, Chi-Chung

    2012-02-01

    Effective expression of porcine interferon-α (pIFN-α) with recombinant Pichia pastoris was conducted in a bench-scale fermentor. The influence of the glycerol feeding strategy on the specific growth rate and protein production was investigated. The traditional DO-stat feeding strategy led to very low cell growth rate resulting in low dry cell weight (DCW) of about 90 g/L during the subsequent induction phase. The previously reported Artificial Neural Network Pattern Recognition (ANNPR) model-based glycerol feeding strategy improved the cell density to 120 g DCW/L, while the specific growth rate decreased from 0.15 to 0.18 to 0.03-0.08 h(-1) during the last 10 h of the glycerol feeding stage leading to a variation of the porcine interferon-α production, as the glycerol feeding scheme had a significant effect on the induction phase. This problem was resolved by an improved ANNPR model-based feeding strategy to maintain the specific growth rate above 0.11 h(-1). With this feeding strategy, the pIFN-α concentration reached a level of 1.43 g/L, more than 1.5-fold higher than that obtained with the previously adopted feeding strategy. Our results showed that increasing the specific growth rate favored the target protein production and the glycerol feeding methods directly influenced the induction stage. Consequently, higher cell density and specific growth rate as well as effective porcine interferon-α production have been achieved by our novel glycerol feeding strategy.

  6. On-line and Mobil Learning Activities

    Science.gov (United States)

    Ackerman, S. A.; Whittaker, T. M.; Jasmin, T.; Mooney, M. E.

    2012-12-01

    Introductory college-level science courses for non-majors are critical gateways to imparting not only discipline-specific information, but also the basics of the scientific method and how science influences society. They are also indispensable for student success to degree. On-line, web-based homework (whether on computers or mobile devices) is a rapidly growing use of the Internet and is becoming a major component of instruction in science, replacing delayed feedback from a few major exams. Web delivery and grading of traditional textbook-type questions is equally effective as having students write them out for hand grading, as measured by student performance on conceptual and problem solving exams. During this presentation we will demonstrate some of the interactive on-line activities used to teach concepts and how scientists approach problem solving, and how these activities have impacted student learning. Evaluation of the activities, including formative and summative, will be discussed and provide evidence that these interactive activities significantly enhance understanding of introductory meteorological concepts in a college-level science course. More advanced interactive activities are also used in our courses for department majors, some of these will be discussed and demonstrated. Bring your mobile devices to play along! Here is an example on teaching contouring: http://profhorn.aos.wisc.edu/wxwise/contour/index.html

  7. Arsenic speciation analysis in mono-varietal wines by on-line ionic liquid-based dispersive liquid-liquid microextraction.

    Science.gov (United States)

    Escudero, Leticia B; Martinis, Estefanía M; Olsina, Roberto A; Wuilloud, Rodolfo G

    2013-05-01

    A highly efficient separation and pre-concentration method for arsenic species determination, based on ionic liquid (IL) dispersive microextraction technique implemented in a flow analysis system, is proposed. Highly selective separation of arsenite species [As(III)] was achieved by chelation with sodium diethyldithiocarbamate (DDTC) followed by dispersion with 40 mg of 1-octyl-3-methylimidazolium hexafluorophosphate ([C(8)mim][PF(6)]) IL. Analyte extraction, retention and separation of IL phase were achieved with a packed microcolumn and As(III) was determined in eluent solution by electrothermal atomic absorption spectrometry (ETAAS). Concentration of As(V) was deduced by the difference between total inorganic arsenic and As(III). Thus, determination of total arsenic was performed by previous degradation of organo-arsenic species, followed by a reduction. Under optimal conditions, As(III) extraction efficiency was 100% and a sensitivity enhancement factor of 46 was obtained with only 4.0 ml of sample The method was successfully applied for arsenic speciation studies in mono-varietal wines.

  8. SeaBuoySoft – an On-line Automated Windows based Ocean Wave height Data Acquisition and Analysis System for Coastal Field’s Data Collection

    Directory of Open Access Journals (Sweden)

    P.H.Tarudkar

    2014-12-01

    Full Text Available Measurement of various hydraulic parameters such as wave heights for the research and the practical purpose in the coastal fields is one of the critical and challenging but equally important criteria in the field of ocean engineering for the design and the development of hydraulic structures such as construction of sea walls, break waters, oil jetties, fisheries harbors, all other structures, and the ships maneuvering, embankments, berthing on jetties. This paper elucidates the development of “SeaBuoySoft online software system for coastal field‟s wave height data collection” for the coastal application work. The system could be installed along with the associated hardware such as a Digital Waverider Receiver unit and a Waverider Buoy at the shore. The ocean wave height data, transmitted by wave rider buoy installed in the shallow/offshore waters of sea is received by the digital waverider receiver unit and it is interfaced to the SeaBuoySoft software. The design and development of the software system has been worked out in-house at Central Water and Power Research Station, Pune, India. The software has been developed as a Windows based standalone version and is unique of its kind for the reception of real time ocean wave height data, it takes care of its local storage of wave height data for its further analysis work as and when required. The system acquires real time ocean wave height data round the clock requiring no operator intervention during data acquisition process on site.

  9. On-line gaseous formaldehyde detection by a microfluidic analytical method based on simultaneous uptake and derivatization in a temperature controlled annular flow.

    Science.gov (United States)

    Guglielmino, Maud; Bernhardt, Pierre; Trocquet, Claire; Serra, Christophe A; Le Calvé, Stéphane

    2017-09-01

    This paper is focused on the improvement of a microfluidic analytical method for the detection of low airborne formaldehyde concentrations, based on only two distinct steps permitting to reduce the response time and to improve the compactness of the device. First, gaseous formaldehyde is trapped into an acetylacetone solution at 65°C through an annular liquid/gas flow and reacts immediately to form 3,5-Diacetyl-1,4-dihydrolutidine which is then quantified by colorimetry using a liquid core waveguide (LCW). To obtain an annular flow, 3 different hydrophilic silica capillaries of 320, 450 and 530µm ID were tested and the corresponding phase diagrams were obtained in the ranges of liquid and gas flows of 5-35µLmin(-1) and 5-35mLmin(-1) respectively. Finally, the analytical performances were determined using the lowest flow values of 5µLmin(-1) and 5NmLmin(-1), ensuring an annular flow and increasing the microdevice autonomy. If the uptake yield of gaseous formaldehyde into the solution was close to 100%, only the 530µm ID capillary permits to obtain a reaction time long enough for a full conversion of formaldehyde into 3,5-Diacetyl-1,4-dihydrolutidine. With a LCW pathlength of 5cm, the microdevice response was perfectly linear in the range 0-154µgm(-3) with a detection limit of 1.8µgm(-3). Copyright © 2017 Elsevier B.V. All rights reserved.

  10. Simple and Excellent Selective Chemiluminescence-Based CS2 On-Line Detection System for Rapid Analysis of Sulfur-Containing Compounds in Complex Samples.

    Science.gov (United States)

    Zhang, Runkun; Li, Gongke; Hu, Yufei

    2015-06-02

    To study the interesting chemical reaction phenomenon can greatly contribute to the development of an innovative analytical method. In this paper, a simple CL reaction cell was constructed to study the chemiluminescence (CL) emission from the thermal oxidation of carbon disulfide (CS2). We found that the CL detection of CS2 exhibits unique characteristics of excellent selectivity and rapid response capacity. Experimental investigations together with theoretical calculation were performed to study the mechanism behind the CL reaction. The results revealed that the main luminous intermediates generated during the thermal degradation of CS2 are SO2* and CO2*. Significantly, this CL emission phenomenon has a wide application due to many sulfur-containing compounds that can convert to CS2 under special conditions. On the basis of this scheme, a CS2-generating and detection system was developed for rapid measurement of CS2 or other compounds that can convert to CS2. The usefulness of the system was demonstrated by measuring dithiocarbamate (DTC) pesticides (selected mancozeb as a representative analyte) based on the evolution of CS2 in spiked agricultural products. Results showed that the system allows online and large volume detection of CS2 under nonequilibrium condition, which greatly reduces the analytical time. The concentrations of mancozeb in the spiked samples were well-quantified with satisfied recoveries of 76.9-97.3%. The system not only addresses the urgent need for rapid in-field screening of DTC residues in foodstuffs but also opens a new opportunity for the fast, convenient, and cost-effective detection of CS2 and some other sulfur-containing compounds in complex samples.

  11. The Construction of the on-line Customization System based on Silverlight%基于Silverlight的在线定制系统的构建

    Institute of Scientific and Technical Information of China (English)

    蔡志恒

    2012-01-01

    名字首饰在线定制需要耗费大量的人工成本,主要表现在定制服务提供商与顾客、首饰生产商之间的频繁沟通。这个沟通过程繁琐且耗时,人工成本在名字首饰定制中占很大的比重。基于Silverlight RIA的名字首饰在线定制生产系统,通过改良Web交互性能,改造企业的业务流程,解决电子商务企业运营中遇到的实际问题,该系统降低了人工成本,提高了生产效率。Silverlight RIA在电子商务的这个解决方案,可以作为其他类似场合的借鉴。%The name jewelry online customization needs to consume a large number of labour cost,which primarily shows in frequent communication between customized service providers and customers,and between jewelry manufacturers.This process of communication is cumbersome and time-consuming,labour cost accounts for a large proportion in the name jewelry customization. Based on Silverlight RIA,the production system of name jewelry online customization reduces the labor cost and improves productivity by upgrading Web interactive performance and transforming business process,and the production system also solves the practical problems in the process of E-business enterprise operation.The solution of Silverlight RIA in the E-business can be used for reference in other similar occasion.

  12. Patient repositioning and pressure ulcer risk--monitoring interface pressures of at-risk patients.

    Science.gov (United States)

    Peterson, Matthew J; Gravenstein, Nikolaus; Schwab, Wilhelm K; van Oostrom, Johannes H; Caruso, Lawrence J

    2013-01-01

    Repositioning patients regularly to prevent pressure ulcers and reduce interface pressures is the standard of care, yet prior work has found that standard repositioning does not relieve all areas of at-risk tissue in nondisabled subjects. To determine whether this holds true for high-risk patients, we assessed the effectiveness of routine repositioning in relieving at-risk tissue of the perisacral area using interface pressure mapping. Bedridden patients at risk for pressure ulcer formation (n = 23, Braden score pressures recorded every 30 s while they received routine repositioning care for 4-6 h. All participants had specific skin areas (206 +/- 182 cm(2)) that exceeded elevated pressure thresholds for >95% of the observation period. Thirteen participants were observed in three distinct positions (supine, turned left, turned right), and all had specific skin areas (166 +/- 184 cm(2)) that exceeded pressure thresholds for >95% of the observation period. At-risk patients have skin areas that are likely always at risk throughout their hospital stay despite repositioning. Healthcare providers are unaware of the actual tissue-relieving effectiveness (or lack thereof) of their repositioning interventions, which may partially explain why pressure ulcer mitigation strategies are not always successful. Relieving at-risk tissue is a necessary part of pressure ulcer prevention, but the repositioning practice itself needs improvement.

  13. The 1-way on-line coupled model system MECO(n) - Part 4: Chemical evaluation (based on MESSy v2.52)

    Science.gov (United States)

    Mertens, Mariano; Kerkweg, Astrid; Jöckel, Patrick; Tost, Holger; Hofmann, Christiane

    2016-10-01

    For the first time, a simulation incorporating tropospheric and stratospheric chemistry using the newly developed MECO(n) model system is performed. MECO(n) is short for MESSy-fied ECHAM and COSMO models nested n times. It features an online coupling of the COSMO-CLM model, equipped with the Modular Earth Submodel System (MESSy) interface (called COSMO/MESSy), with the global atmospheric chemistry model ECHAM5/MESSy for Atmospheric Chemistry (EMAC). This online coupling allows a consistent model chain with respect to chemical and meteorological boundary conditions from the global scale down to the regional kilometre scale. A MECO(2) simulation incorporating one regional instance over Europe with 50 km resolution and one instance over Germany with 12 km resolution is conducted for the evaluation of MECO(n) with respect to tropospheric gas-phase chemistry. The main goal of this evaluation is to ensure that the chemistry-related MESSy submodels and the online coupling with respect to the chemistry are correctly implemented. This evaluation is a prerequisite for the further usage of MECO(n) in atmospheric chemistry-related studies. Results of EMAC and the two COSMO/MESSy instances are compared with satellite, ground-based and aircraft in situ observations, focusing on ozone, carbon monoxide and nitrogen dioxide. Further, the methane lifetimes in EMAC and the two COSMO/MESSy instances are analysed in view of the tropospheric oxidation capacity. From this evaluation, we conclude that the chemistry-related submodels and the online coupling with respect to the chemistry are correctly implemented. In comparison with observations, both EMAC and COSMO/MESSy show strengths and weaknesses. Especially in comparison to aircraft in situ observations, COSMO/MESSy shows very promising results. However, the amplitude of the diurnal cycle of ground-level ozone measurements is underestimated. Most of the differences between COSMO/MESSy and EMAC can be attributed to differences in the

  14. Study on BOTDR technology-based OPGW on-line monitoring%基于BOTDR技术的OPGW在线监测研究

    Institute of Scientific and Technical Information of China (English)

    李永倩; 翟丽娜; 赵丽娟; 宋士刚

    2013-01-01

    For ensuring the secure operation of power system communications,real-time monitoring of the running state of the OPtical fiber composite overhead Ground Wire (OPGW)is necessary.This paper presents a method on the basis of the Bril-louin Optical Time Domain Reflectometry (BOTDR)technology,in which real-time monitoring is performed on the OPGW temperature and strain.Then,it calibrates the temperature and strain coefficients of G.652 optical fiber in OPGW.On the ba-sis of the experimental results,it studies the temperature and strain distribution of OPGW in field operation and analyzes the faults brought about by temperature and strain using the differential method and the relative value method.The results indicate that the BOTDR-based online monitoring system can realize real-time measurement of distributed temperature and strain and fault location for OPGW.%为保证电力系统通信的安全运行,实时监测 OPGW(光纤复合架空地线)的运行状态,提出了基于 BOTDR(布里渊光时域反射)技术对 OPGW线路温度和应变实时监测的方法。采用加温加压的方法,对 OPGW纤芯 G.652光纤的温度和应变系数进行了标定,基于实验结论,对现场运行的 OPGW线路温度和应变的分布进行了研究。同时采用差值法和相对值法分别对温度和应变引起的故障进行了分析,分析结果表明,该系统能实现 OPGW分布式温度和应变的实时测量和故障点定位。

  15. Demonstration of a Novel Synchrophasor-based Situational Awareness System: Wide Area Power System Visualization, On-line Event Replay and Early Warning of Grid Problems

    Energy Technology Data Exchange (ETDEWEB)

    Rosso, A.

    2012-12-31

    Since the large North Eastern power system blackout on August 14, 2003, U.S. electric utilities have spent lot of effort on preventing power system cascading outages. Two of the main causes of the August 14, 2003 blackout were inadequate situational awareness and inadequate operator training In addition to the enhancements of the infrastructure of the interconnected power systems, more research and development of advanced power system applications are required for improving the wide-area security monitoring, operation and planning in order to prevent large- scale cascading outages of interconnected power systems. It is critically important for improving the wide-area situation awareness of the operators or operational engineers and regional reliability coordinators of large interconnected systems. With the installation of large number of phasor measurement units (PMU) and the related communication infrastructure, it will be possible to improve the operators’ situation awareness and to quickly identify the sequence of events during a large system disturbance for the post-event analysis using the real-time or historical synchrophasor data. The purpose of this project was to develop and demonstrate a novel synchrophasor-based comprehensive situational awareness system for control centers of power transmission systems. The developed system named WASA (Wide Area Situation Awareness) is intended to improve situational awareness at control centers of the power system operators and regional reliability coordinators. It consists of following main software modules: • Wide-area visualizations of real-time frequency, voltage, and phase angle measurements and their contour displays for security monitoring. • Online detection and location of a major event (location, time, size, and type, such as generator or line outage). • Near-real-time event replay (in seconds) after a major event occurs. • Early warning of potential wide-area stability problems. The system has been

  16. Tunable diode laser absorption spectroscopy-based tomography system for on-line monitoring of two-dimensional distributions of temperature and H{sub 2}O mole fraction

    Energy Technology Data Exchange (ETDEWEB)

    Xu, Lijun, E-mail: lijunxu@buaa.edu.cn; Liu, Chang; Jing, Wenyang; Cao, Zhang [School of Instrument Science and Opto-Electronic Engineering, Beihang University, Beijing 100191 (China); Ministry of Education’s Key Laboratory of Precision Opto-Mechatronics Technology, Beijing 100191 (China); Xue, Xin; Lin, Yuzhen [School of Energy and Power Engineering, Beihang University, Beijing 100191 (China)

    2016-01-15

    To monitor two-dimensional (2D) distributions of temperature and H{sub 2}O mole fraction, an on-line tomography system based on tunable diode laser absorption spectroscopy (TDLAS) was developed. To the best of the authors’ knowledge, this is the first report on a multi-view TDLAS-based system for simultaneous tomographic visualization of temperature and H{sub 2}O mole fraction in real time. The system consists of two distributed feedback (DFB) laser diodes, a tomographic sensor, electronic circuits, and a computer. The central frequencies of the two DFB laser diodes are at 7444.36 cm{sup −1} (1343.3 nm) and 7185.6 cm{sup −1} (1391.67 nm), respectively. The tomographic sensor is used to generate fan-beam illumination from five views and to produce 60 ray measurements. The electronic circuits not only provide stable temperature and precise current controlling signals for the laser diodes but also can accurately sample the transmitted laser intensities and extract integrated absorbances in real time. Finally, the integrated absorbances are transferred to the computer, in which the 2D distributions of temperature and H{sub 2}O mole fraction are reconstructed by using a modified Landweber algorithm. In the experiments, the TDLAS-based tomography system was validated by using asymmetric premixed flames with fixed and time-varying equivalent ratios, respectively. The results demonstrate that the system is able to reconstruct the profiles of the 2D distributions of temperature and H{sub 2}O mole fraction of the flame and effectively capture the dynamics of the combustion process, which exhibits good potential for flame monitoring and on-line combustion diagnosis.

  17. Persistent otolith dysfunction even after successful repositioning in benign paroxysmal positional vertigo.

    Science.gov (United States)

    Kim, Eui-Joong; Oh, Sun-Young; Kim, Ji Soo; Yang, Tae-Ho; Yang, Si-Young

    2015-11-15

    To evaluate utricular and saccular function during the acute and resolved phases of BPPV, ocular and cervical vestibular evoked myogenic potentials (VEMPs) were studied in 112 patients with BPPV and 50 normal controls in a referral-based University Hospital. Ocular (oVEMPs) and cervical VEMPs (cVEMPs) were induced using air-conducted sound (1000Hz tone burst, 100dB normal hearing level) at the time of initial diagnosis and 2 months after successful repositioning in patients with BPPV, and the results were compared with those of the controls. Abnormalities of cVEMPs and oVEMPs in patients with BPPV were prevalent and significantly higher compare to the healthy control group (pVEMP by chi-square test). In the patient group, difference between the proportions of abnormal responses of cVEMP and oVEMP was not significant in both affected (p=0.37, chi-squared test) and non-affected (p=1.00) ears. The abnormalities were more likely reduced or absent responses rather than delayed ones; reduced or absent responses are 17.6% in cVEMPs (p=0.04, chi-square) and 21.6% in oVEMPs (pVEMPs after repositioning maneuvers were not significantly different compared to the initial values from both stimulated affected and non-affected ears. Although most patients had unilateral BPPV, bilateral otolithic dysfunction was often shown by persistently reduced or absent cervical and ocular VEMPs, suggesting that BPPV may be caused by significant bilateral damage to the otolith organs. Copyright © 2015 Elsevier B.V. All rights reserved.

  18. A case of upside-down stomach that was effectively treated by postprandial repositioning.

    Science.gov (United States)

    Ono, Kazumasa; Hasegawa, Hiroshi; Obara, Toshimasa; Miyagishima, Kei; Inoue, Shinichiro; Kozaki, Koichi

    2017-01-01

    An 88-year-old woman with a history of stomach perforation and lumbar compression fracture was admitted to our hospital with a chief complaint of continuous vomiting, which she had experienced since the previous day. She showed vomiting, spontaneous pain and tenderness from the epigastric fossa through the left flank. In addition, she had marked kyphosis. On a CT scan, although the fornix was located in the abdominal cavity, the antrum and body had escaped into the thoracic cavity. A large volume of gastric content was observed. The patient was diagnosed with upside-down stomach from gastric volvulus and a hiatal hernia. Although we recommended surgery, the patient and her family did not agree with it. Thus, conservative therapy was selected. The patient's symptoms showed a significant improvement after the placement of a nasogastric tube, fasting and fluid therapy. After stabilization, an endoscopic examination was performed. The release of the gastric volvulus was confirmed and the nasogastric tube was removed. We instructed the patient to perform postprandial repositioning, which was based on the running shape of the digestive tract with the goal of achieving the passage of food and preventing a relapse of vomiting. The patient was instructed to first place herself in the right lateral decubitus position and then the prone position after eating. There was no recurrence of vomiting after the patient resumed eating. She was therefore discharged from our hospital. Upside-down stomach is usually an indication for surgery. However, in elderly patients, the fixation of the stomach to the abdominal wall has been reported to occur after endoscopic reduction, and conservative treatment was thus selected in this case.We herein reported a case in which postprandial repositioning was used to treat upside-down stomach.

  19. 基于线性学习函数的泛证券投资组合策略%Universal portfolio based on on-line learning of linear function

    Institute of Scientific and Technical Information of China (English)

    张卫国; 张永; 徐维军; 杨兴雨

    2012-01-01

    The return of the best constant rebalanced portfolio (BCRP) has exponential growth rate with time. It is a hot topic to research on-line sequential investment strategy that has the same growth rate as BCRP. Based on the on-line learning of linear function, we firstly present a new on-line portfolio selection strategy, where the linear coefficient is the middle of an interval. And the interval is related to price relative and the return. Using the relative entropy as the distance function of two portfolios, we further prove that the new on-line portfolio is universal. Finally, take experiment on several portfolios that consisted of two stocks or three stocks, and compare the new strategy with Cover's UP strategy. The results show that this new strategy can obtain better performance. Therefore, this paper provides a new method and basis for decision-making for on-line sequential investment, and thus has great practical significance.`%最优定常再调整策略所产生的收益随时间成指数速度增长,寻找与最优定常再调整策略的收益具有相同指数增长率的在线序贯投资组合是近年来投资组合研究的一个热点.首先提出了基于线性学习函数的在线投资组合策略,其中线性函数的系数是一个与股票相对价格和收益有关的区间的中点.用相对熵函数定义两个投资组合向量之间的距离,进一步证明了基于线性函数的在线投资组合策略是泛证券投资组合.最后,分别在两支股票和三支股票组成的多个投资组合上进行了数值计算,并与Cover等人提出的泛证券投资组合策略进行了比较.结果表明这种基于线性学习函数的在线投资组合策略能获得更多的收益,从而为投资者提供了新的在线序贯投资组合决策的方法和依据,具有重要的现实指导意义.

  20. Augmented reality as an aid in maxillofacial surgery: validation of a wearable system allowing maxillary repositioning.

    Science.gov (United States)

    Badiali, Giovanni; Ferrari, Vincenzo; Cutolo, Fabrizio; Freschi, Cinzia; Caramella, Davide; Bianchi, Alberto; Marchetti, Claudio

    2014-12-01

    We present a newly designed, localiser-free, head-mounted system featuring augmented reality as an aid to maxillofacial bone surgery, and assess the potential utility of the device by conducting a feasibility study and validation. Our head-mounted wearable system facilitating augmented surgery was developed as a stand-alone, video-based, see-through device in which the visual features were adapted to facilitate maxillofacial bone surgery. We implement a strategy designed to present augmented reality information to the operating surgeon. LeFort1 osteotomy was chosen as the test procedure. The system is designed to exhibit virtual planning overlaying the details of a real patient. We implemented a method allowing performance of waferless, augmented-reality assisted bone repositioning. In vitro testing was conducted on a physical replica of a human skull, and the augmented reality system was used to perform LeFort1 maxillary repositioning. Surgical accuracy was measured with the aid of an optical navigation system that recorded the coordinates of three reference points (located in anterior, posterior right, and posterior left positions) on the repositioned maxilla. The outcomes were compared with those expected to be achievable in a three-dimensional environment. Data were derived using three levels of surgical planning, of increasing complexity, and for nine different operators with varying levels of surgical skill. The mean error was 1.70 ± 0.51 mm. The axial errors were 0.89 ± 0.54 mm on the sagittal axis, 0.60 ± 0.20 mm on the frontal axis, and 1.06 ± 0.40 mm on the craniocaudal axis. The simplest plan was associated with a slightly lower mean error (1.58 ± 0.37 mm) compared with the more complex plans (medium: 1.82 ± 0.71 mm; difficult: 1.70 ± 0.45 mm). The mean error for the anterior reference point was lower (1.33 ± 0.58 mm) than those for both the posterior right (1.72 ± 0.24 mm) and posterior left points (2.05 ± 0.47 mm). No significant difference

  1. On Line Fault Diagnosis of Waveform-Based Recognition on a Loc omotive%基于波形识别的机车电气设备在线故障诊断

    Institute of Scientific and Technical Information of China (English)

    王立德; 郭其一

    2000-01-01

    The methods of an on line waveform perception and fau lt diagnosis reasoning based on modeling and fuzzy recognition were discussed.A practical reasoning pattern of dynamic fault location was constructed.Also,the c onclusion has been used in an electric locomotive successfully.%就基于模糊模式识别技术基础上的在线波形理解与诊断推理计 算进行了讨论,构造了一个实用的在线动态诊断系统,通过机车瞬间故障检测记录系统予以 实现。

  2. Simultaneous premaxillary repositioning and cheiloplasty in adult patients with unrepaired bilateral cleft lip and palate.

    Science.gov (United States)

    Lee, Ui-Lyong; Cho, Jun-Bum; Choung, Pill-Hoon

    2013-03-01

    Primary cheiloplasty in adult patients with unrepaired complete bilateral cleft lip and palate is quite challenging due to severe premaxillary anterior projection. To get the best repair results, the author carried out repositioning of the premaxilla and repair of the lip deformity in a single stage. Positive results for the primary lip repair and appropriate repositioning of the premaxilla were achieved. No avascular necrosis of the premaxilla was observed. Repositioning of the premaxilla and repair of the lip deformity in a single operation appears to be a reliable method for treating adult patients with previously unrepaired or poorly repaired bilateral cleft lip and palate.

  3. Observation of curative effect of modified canalith reposition on 48 cases with benign paroxysmal positional vertigo

    Directory of Open Access Journals (Sweden)

    LAN Jun

    2012-02-01

    Full Text Available Objective To investigate the therapeutic efficacy of the canalith repositioning maneuver in benign paroxysmal positional vertigo (BPPV. Methods The modified Epley procedure, Semont maneuver and Barbecue maneuver were applied in 48 cases of BPPV. Followed for one year, the curative effects were observed. Results After treatment in modified canalith reposition, the recovery rate was 89.58% , and effective rate was 100% . Followed for one year, the recurrence rate was 6.25% . Conclusion Modified canalith reposition for BPPV has no contraindications, and no special adverse reactions. It is simple and can fastly relieve symptoms. The cost and recurrence rate are low. It is suitable for clinical application.

  4. Are on-line currencies virtual banknotes?

    OpenAIRE

    Stephen F. Quinn; William Roberds

    2003-01-01

    The history of money is marked by innovations that have expanded the role of "inside money"-money created by the private sector. For instance, the past few years have seen the development of several types of on-line payment arrangements, some of which have been dubbed "on-line currencies." ; This article examines the likely success or failure of on-line currencies by means of a historical analogy. The discussion compares the introduction of on-line currencies to the debut of the bearer bankno...

  5. 基于加热法的蒸汽湿度在线监测模型及工业试验研究%On-line Monitoring Model and Industrial Test of Steam Humidity based on Heating Method

    Institute of Scientific and Technical Information of China (English)

    王升龙; 李俊朋; 杨善让; 索英杰; 牛棚满

    2016-01-01

    提出一种基于加热法的湿度在线监测模型,并研制了新型湿度测量探针。采用了内加热螺旋通道、等温套管等结构的湿度测量探针在测量过程不仅能适应排汽高速流动,而且有效地避免了散热损失。该湿度测量探针在一台320MW机组上进行了工业试验,试验结果表明所测数据有效且有较高精度,可满足电厂汽轮机排汽湿度在线测量的需要。%An on-line monitoring model of steam humidity based on heating method is presented ,and a new type of humidity measuring probe is developed .In the measurement process , the internal heating spiral path , isothermal tube and other structure of the humidity measuring probe in the measurement process not only can adapt to the high speed flow ,but also effectively avoid the loss of heat.The humidity measuring probe is carried out on a 320MW set,the test results show that the measured data is valid and has higher precision ,which can meet the requirement of on-line measurement of steam turbine exhaust wetness in power plant .

  6. 基于经验模态分解与神经网络的在线状态监测%On-line Condition Monitoring Based on Empirical Mode Decomposition and Neural Network

    Institute of Scientific and Technical Information of China (English)

    谢锋云

    2013-01-01

    在机械加工过程,为了提高加工稳定性和精度,在线状态监测具有十分重要的作用。基于经验模态分解与神经网络模型,提出了一个在线状态监测方法。该方法将EMD分解的本征模态函数均方根作为机械加工特征量。为识别实时加工状态,以加工特征为神经网络的目标输入,建立起将IMF作为特征参数及把3种加工状态作为输出的3层后向神经网络模型。识别的结果显示,提出的方法能有效地识别加工状态。%On-line condition monitoring in machining processes plays a significant role to improve the machining stability and precision.In this paper,an approach based on empirical mode de-composition (EMD)and neural network for on-line condition monitoring is proposed.The root mean square (RMS)of intrinsic mode functions (IMFs)by EMD is regarded as machining pro-cessing feature.The three layers Back-propagation (BP)neural network model taking the ma-chining feature as target input of neural network,the IMFs as characteristic parameter,and the 3 types of processing states as output are established to identify the processing state.The result shows that the proposed method can effectively identify the state of of process.

  7. Study on Edge Extraction Methods for Image-based Icing On-line Monitoring on Overhead Transmission Lines%输电线路覆冰图像边缘提取方法研究

    Institute of Scientific and Technical Information of China (English)

    王小朋; 胡建林; 吴彬

    2008-01-01

    A new method of measuring the icing thickness of transmission lines on-line is proposed in this paper. In this method, the pictures of transmission lines which are photoed by the camera on the iron tower are processed immediately to extract the edges of the transmission line conductor and transmission line insulators. The icing thickness can be gained by comparing the edges of the iced transmission line and the uniced one. Two icing image edge extraction methods are described in detail, that is, a method based on the combination of the wavelet transform and the floating threshold method and a method based on the combination of the optimal threshold method and the mathematical morphology transform. The icing images from the artificial climatic chamber and transmission lines are used to test the methods above. The results show that the method based on the wavelet transform and the floating threshold method does well in the extraction of relatively smooth edges, such as glaze icing on conductor and icing on the insulator;meanwhile, the method based on the optimal threshold method and the mathematical morphology transform does well in the edge extraction of icing on the conductor, especially the opaque rime icing on the conductor with complicated edges.

  8. On-Line Dynamic Index Hybrid Update Scheme Based on Self-Learning of Allocated Space%基于分配空间自学习的在线动态索引混合更新机制

    Institute of Scientific and Technical Information of China (English)

    刘小珠; 彭智勇

    2012-01-01

    To improve time and space efficiencies of index maintenance, an on-line dynamic index hybrid update (ODIHU) technique is proposed based on self-learning of allocated space. Based on Zipf theorem, ODIHU appropriately estimates the number of short and long lists with theoretical analysis, and manages short and long lists with uniform storage model of distinguishing long and short lists based on link. ODIHU manages long list space with history-based adaptive learning allocation (HALA) , and manages short list space with linear allocation (LA), exponential allocation (EA) , and uniform allocation (UA). To decrease index and retrieval cost, ODIHU divides index data set into limited sections and controls index merge with schemes. Then ODIHU merges short lists with immediate merge, and merges long lists with improved Y-limited contiguous multiple merge scheme, which balances the trade-off of the time and space efficiencies effectively. Based on the proposed RABIF, ODIHU not only considers both index level and inverted list level updating, but also effectively improves time and space efficiencies of index updating.%针对索引维护时间和空间效率低的问题,提出了一种基于分配空间自学习的在线动态索引混合更新机制(on-line dynamic index hybrid update,ODIHU).ODIHU根据Zipf分布原理对长短列表数量分布进行估计,并采用基于历史分配空间的自适应学习机制对长短列表空间进行有效管理,然后对短列表采用立即合并更新方式,长列表采用上限Y相邻多路合并的更新方式维护,实现索引更新与查询性能的有效折中.理论分析及实验结果表明,ODIHU能有效地提高索引维护与更新过程中的空间效率、索引合并与查询时间效率.

  9. Repositioning reference new methods and new services for a new age

    CERN Document Server

    Rozaklis, Lillian

    2014-01-01

    Repositioning Reference reimagines reference services in libraries and information organizations and the role of reference librarians, taking into account rapid developments in technology and information-specific services in non-library sectors.

  10. The physiological response of soft tissue to periodic repositioning as a strategy for pressure ulcer prevention

    NARCIS (Netherlands)

    Woodhouse, M.; Worsley, P.R.; Voegeli, D.; Schoonhoven, L.; Bader, D.L.

    2015-01-01

    BACKGROUND: Individuals who have reduced mobility are at risk of developing pressure ulcers if they are subjected to sustained static postures. To reduce this risk, clinical guidelines advocate healthcare professionals reposition patients regularly. Automated tilting mechanisms have recently been

  11. On line routing per mobile phone

    DEFF Research Database (Denmark)

    Bieding, Thomas; Görtz, Simon; Klose, Andreas

    2009-01-01

    On-line routing is concerned with building vehicle routes in an ongoing fashion in such a way that customer requests arriving dynamically in time are efficiently and effectively served. An indispensable prerequisite for applying on-line routing methods is mobile communication technology. Addition...

  12. Aprender a innovar: una experiencia on line

    Directory of Open Access Journals (Sweden)

    Joaquín MORENO MARCHAL

    2014-11-01

    Full Text Available La creatividad y la innovación se han convertido en recursos clave en la denominada sociedad del conocimiento, que bien podría ser también llamada sociedad de la innovación. Pero innovar es una actividad compleja, que integra la aplicación de múltiples capacidades, el pensamiento divergente y convergente, la gestión de equipos humanos, la comunicación. Ahora bien, a innovar se puede, y se debe, aprender. Aprender a innovar es un reto y también una obligación para el conjunto del sistema educativo en todos sus niveles. Partiendo de estas consideraciones este trabajo expone una experiencia de aprendizaje de la creatividad y de la innovación a través de un curso totalmente on line basado en la plataforma MOODLE, en el marco del Programa de Formación Permanente de la Universidad de Cádiz. Se presenta un modelo del proceso de innovación, denominado CREALAB, de elaboración propia. Este modelo se ha utilizado como base del proceso de aprendizaje de la creatividad y de la innovación y en el diseño del curso, está organizado en torno a actividades y tiene un carácter iterativo y realimentado. Se presentan además el conjunto del diseño metodológico y los resultados obtenidos en las dos ediciones celebradas hasta el momento. El diseño del curso totalmente on line y los resultados alcanzados permiten estimar un alto potencial de aplicación, tanto a nivel personal como a nivel organizacional.

  13. On-line chemical composition analyzer development

    Energy Technology Data Exchange (ETDEWEB)

    Roberts, M.J.; Garrison, A.A.; Muly, E.C.; Moore, C.F.

    1992-02-01

    The energy consumed in distillation processes in the United States represents nearly three percent of the total national energy consumption. If effective control of distillation columns can be accomplished, it has been estimated that it would result in a reduction in the national energy consumption of 0.3%. Real-time control based on mixture composition could achieve these savings. However, the major distillation processes represent diverse applications and at present there does not exist a proven on-line chemical composition sensor technology which can be used to control these diverse processes in real-time. This report presents a summary of the findings of the second phase of a three phase effort undertaken to develop an on-line real-time measurement and control system utilizing Raman spectroscopy. A prototype instrument system has been constructed utilizing a Perkin Elmer 1700 Spectrometer, a diode pumped YAG laser, two three axis positioning systems, a process sample cell land a personal computer. This system has been successfully tested using industrially supplied process samples to establish its performance. Also, continued application development was undertaken during this Phase of the program using both the spontaneous Raman and Surface-enhanced Raman modes of operation. The study was performed for the US Department of Energy, Office of Industrial Technologies, whose mission is to conduct cost-shared R D for new high-risk, high-payoff industrial energy conservation technologies. Although this document contains references to individual manufacturers and their products, the opinions expressed on the products reported do not necessarily reflect the position of the Department of Energy.

  14. On-line brain-computer interface system design based on alpha wave and motor imagery%基于脑电alpha波及运动想象的在线脑机接口系统设计

    Institute of Scientific and Technical Information of China (English)

    王磊; 王江; 刘丽芳; 杨硕; 徐桂芝; 颜威利

    2011-01-01

    背景:目前在线脑机接口系统绝大多数采用同步式设计,无法区分"工作"状态与"空闲"状态.目的:设计一种能够自由在"工作"与"空闲"状态间切换,方便灵活的脑机接口系统.方法:设计了综合睁眼产生的alpha波阻断现象,以及进行运动想象时产生事件相关同步及去同步现象这些生理特征的在线脑机接口系统.通过检测使用者枕部脑电信号alpha波状况,来切换"空闲"与"工作"状态;在"工作"状态下,通过想象不同的肢体运动,分析运动皮质脑电信号的频率特征,来实现对外界的信息传输.结果与结论:实验证明,经过训练的使用者在该在线脑机接口平台上可以自如的在不同状态间进行切换,并且能以很高的分类正确率发出控制命令.采用此方法进行设计,脑机接口系统的实用性得到了增强.%BACKGROUND: At present, most of on-line brain-computer interface (BCI) systems adopt synchronous design, which cannot tell the switch between "active" state and "idle" state.OBJECTIVE: To design an effective BCI system design, which is free to switch between "active" state and "idle" state.METHODS: In this paper, an on-line BCI system was designed based on a series of physiological phenomenon, such as alpha wave-block, event related synchronization (ERS) and event related desynchronization (ERD). Through detecting the EEG recorded from occipital area, the two states being "active" and "idle" could be switched. Under the statement of "active", EEG captured from motor cortex was processed, and the frequency feature was extracted during different motor imagery tasks, in the end, the mind that user wanted to express was estimated.RESULTS AND CONCLUSION: The results show that the subject can switch freely between the two states by using this on-line BCI system after training. Using this method, the practicability of on-line BCI system is getting improved greatly.

  15. On-line re-optimization of prostate IMRT plans for adaptive radiation therapy.

    Science.gov (United States)

    Wu, Q Jackie; Thongphiew, Danthai; Wang, Zhiheng; Mathayomchan, Boonyanit; Chankong, Vira; Yoo, Sua; Lee, W Robert; Yin, Fang-Fang

    2008-02-01

    For intermediate and high risk prostate cancer, both the prostate gland and seminal vesicles are included in the clinical target volume. Internal motion patterns of these two organs vary, presenting a challenge for adaptive treatment. Adaptive techniques such as isocenter repositioning and soft tissue alignment are effective when tumor volumes only exhibit translational shift, while direct re-optimization of the intensity-modulated radiation therapy (IMRT) plan maybe more desirable when extreme deformation or differential positioning changes of the organs occur. Currently, direct re-optimization of the IMRT plan using beamlet (or fluence map) has not been reported. In this study, we report a novel on-line re-optimization technique that can accomplish plan adjustment on-line. Deformable image registration is used to provide position variation information on each voxel along the three dimensions. The original planned dose distribution is used as the 'goal' dose distribution for adaptation and to ensure planning quality. Fluence maps are re-optimized via linear programming, and a plan solution can be achieved within 2 min. The feasibility of this technique is demonstrated with a clinical case with large deformation. Such on-line ART process can be highly valuable with hypo-fractionated prostate IMRT treatment.

  16. On-line re-optimization of prostate IMRT plans for adaptive radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Q Jackie [Department of Radiation Oncology, Duke University Medical Center Durham, NC (United States); Thongphiew, Danthai [Department of Radiation Oncology, Duke University Medical Center Durham, NC (United States); Wang, Zhiheng [Department of Radiation Oncology, Duke University Medical Center Durham, NC (United States); Mathayomchan, Boonyanit [Department of Electrical Engineering and Computer Science, Case Western Reserve University Cleveland, OH (United States); Chankong, Vira [Department of Electrical Engineering and Computer Science, Case Western Reserve University Cleveland, OH (United States); Yoo, Sua [Department of Radiation Oncology, Duke University Medical Center Durham, NC (United States); Lee, W Robert [Department of Radiation Oncology, Duke University Medical Center Durham, NC (United States); Yin, Fang-Fang [Department of Radiation Oncology, Duke University Medical Center Durham, NC (United States)

    2008-02-07

    For intermediate and high risk prostate cancer, both the prostate gland and seminal vesicles are included in the clinical target volume. Internal motion patterns of these two organs vary, presenting a challenge for adaptive treatment. Adaptive techniques such as isocenter repositioning and soft tissue alignment are effective when tumor volumes only exhibit translational shift, while direct re-optimization of the intensity-modulated radiation therapy (IMRT) plan maybe more desirable when extreme deformation or differential positioning changes of the organs occur. Currently, direct re-optimization of the IMRT plan using beamlet (or fluence map) has not been reported. In this study, we report a novel on-line re-optimization technique that can accomplish plan adjustment on-line. Deformable image registration is used to provide position variation information on each voxel along the three dimensions. The original planned dose distribution is used as the 'goal' dose distribution for adaptation and to ensure planning quality. Fluence maps are re-optimized via linear programming, and a plan solution can be achieved within 2 min. The feasibility of this technique is demonstrated with a clinical case with large deformation. Such on-line ART process can be highly valuable with hypo-fractionated prostate IMRT treatment.

  17. On-line re-optimization of prostate IMRT plans for adaptive radiation therapy

    Science.gov (United States)

    Wu, Q. Jackie; Thongphiew, Danthai; Wang, Zhiheng; Mathayomchan, Boonyanit; Chankong, Vira; Yoo, Sua; Lee, W. Robert; Yin, Fang-Fang

    2008-02-01

    For intermediate and high risk prostate cancer, both the prostate gland and seminal vesicles are included in the clinical target volume. Internal motion patterns of these two organs vary, presenting a challenge for adaptive treatment. Adaptive techniques such as isocenter repositioning and soft tissue alignment are effective when tumor volumes only exhibit translational shift, while direct re-optimization of the intensity-modulated radiation therapy (IMRT) plan maybe more desirable when extreme deformation or differential positioning changes of the organs occur. Currently, direct re-optimization of the IMRT plan using beamlet (or fluence map) has not been reported. In this study, we report a novel on-line re-optimization technique that can accomplish plan adjustment on-line. Deformable image registration is used to provide position variation information on each voxel along the three dimensions. The original planned dose distribution is used as the 'goal' dose distribution for adaptation and to ensure planning quality. Fluence maps are re-optimized via linear programming, and a plan solution can be achieved within 2 min. The feasibility of this technique is demonstrated with a clinical case with large deformation. Such on-line ART process can be highly valuable with hypo-fractionated prostate IMRT treatment. Abstract and preliminary data presented at 49th AAPM Annual Meeting, Minneapolis, MN, USA, July 2007.

  18. A physarum-inspired prize-collecting steiner tree approach to identify subnetworks for drug repositioning.

    Science.gov (United States)

    Sun, Yahui; Hameed, Pathima Nusrath; Verspoor, Karin; Halgamuge, Saman

    2016-12-05

    Drug repositioning can reduce the time, costs and risks of drug development by identifying new therapeutic effects for known drugs. It is challenging to reposition drugs as pharmacological data is large and complex. Subnetwork identification has already been used to simplify the visualization and interpretation of biological data, but it has not been applied to drug repositioning so far. In this paper, we fill this gap by proposing a new Physarum-inspired Prize-Collecting Steiner Tree algorithm to identify subnetworks for drug repositioning. Drug Similarity Networks (DSN) are generated using the chemical, therapeutic, protein, and phenotype features of drugs. In DSNs, vertex prizes and edge costs represent the similarities and dissimilarities between drugs respectively, and terminals represent drugs in the cardiovascular class, as defined in the Anatomical Therapeutic Chemical classification system. A new Physarum-inspired Prize-Collecting Steiner Tree algorithm is proposed in this paper to identify subnetworks. We apply both the proposed algorithm and the widely-used GW algorithm to identify subnetworks in our 18 generated DSNs. In these DSNs, our proposed algorithm identifies subnetworks with an average Rand Index of 81.1%, while the GW algorithm can only identify subnetworks with an average Rand Index of 64.1%. We select 9 subnetworks with high Rand Index to find drug repositioning opportunities. 10 frequently occurring drugs in these subnetworks are identified as candidates to be repositioned for cardiovascular diseases. We find evidence to support previous discoveries that nitroglycerin, theophylline and acarbose may be able to be repositioned for cardiovascular diseases. Moreover, we identify seven previously unknown drug candidates that also may interact with the biological cardiovascular system. These discoveries show our proposed Prize-Collecting Steiner Tree approach as a promising strategy for drug repositioning.

  19. Elimination of a "Gummy Smile" With Crown Lengthening and Lip Repositioning.

    Science.gov (United States)

    Mahn, Douglas H

    2016-01-01

    Excessive gingival display is considered unattractive by many patients. A combination of surgical approaches may be required to correct this problem. Clinical crown lengthening involves recontouring crestal bone levels and moving the gingival margin in an apical direction. Lip repositioning reduces gingival display by limiting upper lip movement when smiling. This article describes a case in which a combination of clinical crown lengthening and lip repositioning was used to correct excessive gingival display when smiling.

  20. Correlation between Trunk Posture and Neck Reposition Sense among Subjects with Forward Head Neck Postures

    OpenAIRE

    Han Suk Lee; Hyung Kuk Chung; Sun Wook Park

    2015-01-01

    Objective. To assess the correlation of abnormal trunk postures and reposition sense of subjects with forward head neck posture (FHP). Methods. In all, postures of 41 subjects were evaluated and the FHP and trunk posture including shoulder, scapular level, pelvic side, and anterior tilting degrees were analyzed. We used the head repositioning accuracy (HRA) test to evaluate neck position senses of neck flexion, neck extension, neck right and left side flexion, and neck right and left rotation...

  1. Frequent manual repositioning and incidence of pressure ulcers among bedbound elderly hip fracture patients

    OpenAIRE

    Rich, Shayna E.; Margolis, David; Shardell, Michelle; Hawkes, William G; Miller, Ram R.; Amr, Sania; Baumgarten, Mona

    2010-01-01

    Frequent manual repositioning is an established part of pressure ulcer (PU) prevention, but there is little evidence for its effectiveness. This study examined the association between repositioning and PU incidence among bedbound elderly hip fracture patients, using data from a 2004–2007 cohort study in nine Maryland and Pennsylvania hospitals. Eligible patients (n=269) were age≥65 years, underwent hip fracture surgery, and were bedbound at index study visits (during the first five days of ho...

  2. Canal switch after canalith repositioning procedure for benign paroxysmal positional vertigo.

    Science.gov (United States)

    Lin, Giant C; Basura, Gregory J; Wong, Hiu Tung; Heidenreich, Katherine D

    2012-09-01

    Canal switch is a complication following canalith repositioning procedure (CRP) for posterior canal benign paroxysmal positional vertigo (BPPV). Instead of being returned to the utricle, the loose otoconia migrate into the superior or horizontal semicircular canal. Patients remain symptomatic, and treatment can be ineffective unless the switch is recognized and additional repositioning maneuvers directed toward the appropriate semicircular canal are performed. This report provides the first videographic documentation of canal switch involving conversion of unilateral posterior semicircular canal BPPV to geotropic horizontal canalithiasis.

  3. Skeletal stability after inferior maxillary repositioning without interpositional graft.

    Science.gov (United States)

    Santos, S E; Moreira, R W F; de Moraes, M; Asprino, L; Araujo, M M

    2012-04-01

    True vertical maxillary deficiency is a characteristic of short face syndrome. In these patients, inferior repositioning of the maxilla (IRM) is indicated to improve facial aesthetics and function, but this procedure has been described as the most unstable. The aim of this study was to evaluate the long term, post surgical stability of IRM, fixed with four 2.0mm L-shaped miniplates, without any type of graft. A cephalometric study was performed, analysing linear measurements (anterior nasal spine, the A point, top of the incisor, top of the buccal-mesial cusp of the first molar, and posterior nasal spine on an X-Y coordinate system) traced immediately preoperatively, immediately postoperatively and at least 6 months post operatively. Eight young adult patients who underwent IRM were studied. The average results of this study were: surgical movement of 4.65 mm at I point, 5.32 mm at anterior nasal spine (ANS) point, and 4.70 mm at A point and relapses of 1.60 mm (35%), 2.23 mm (43%) and 2.10 mm (46%), respectively. It was concluded, that IRM using this type of internal rigid fixation without graft is unstable.

  4. Repositórios Institucionais e Objetos Virtuais de Aprendizagem

    Directory of Open Access Journals (Sweden)

    Rosângela Schwarz Rodrigues

    2010-05-01

    Full Text Available O evento “Repositórios Institucionais e Objetos Virtuais de Aprendizagem”, ocorrido nos dias 4, 5 e 6 de novembro de 2009 foi um marco em relação às discussões sobre o referido tema na Universidade Federal de Santa Catarina (UFSC. Organizado pela Biblioteca Central, com o apoio da coordenação da Universidade Aberta do Brasil, da Pró-Reitoria de Graduação e do Programa de Pós-Graduação em Ciência da Informação da UFSC, a abertura do evento contou com a presença do professor Carlos Alberto Justos da Silva, vice-reitor da UFSC (representando o reitor; da professora Maria Lúcia de Camargo, pró-reitora de Pós-Graduação; do diretor de ensino da Pró-reitoria de Assuntos Estudantis, professor Carlos Pinto; da coordenadora da Universidade Aberta do Brasil na UFSC, professora Eleonora Milano Falcão Vieira e da diretora da Biblioteca Central, Narcisa Amboni. O encontro reuniu dezesseis especialistas que apresentaram trabalhos e participaram de discussões com professores, servidores técnico-administrativos e estudantes.Os palestrantes concordaram gentilmente em disponibilizar suas apresentações, que organizamos nesta edição da Encontros Bibli para garantir a visibilidade e segurança.

  5. Microwave assisted saponification (MAS) followed by on-line liquid chromatography (LC)-gas chromatography (GC) for high-throughput and high-sensitivity determination of mineral oil in different cereal-based foodstuffs.

    Science.gov (United States)

    Moret, Sabrina; Scolaro, Marianna; Barp, Laura; Purcaro, Giorgia; Conte, Lanfranco S

    2016-04-01

    A high throughput, high-sensitivity procedure, involving simultaneous microwave-assisted extraction (MAS) and unsaponifiable extraction, followed by on-line liquid chromatography (LC)-gas chromatography (GC), has been optimised for rapid and efficient extraction and analytical determination of mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH) in cereal-based products of different composition. MAS has the advantage of eliminating fat before LC-GC analysis, allowing an increase in the amount of sample extract injected, and hence in sensitivity. The proposed method gave practically quantitative recoveries and good repeatability. Among the different cereal-based products analysed (dry semolina and egg pasta, bread, biscuits, and cakes), egg pasta packed in direct contact with recycled paperboard had on average the highest total MOSH level (15.9 mg kg(-1)), followed by cakes (10.4 mg kg(-1)) and bread (7.5 mg kg(-1)). About 50% of the pasta and bread samples and 20% of the biscuits and cake samples had detectable MOAH amounts. The highest concentrations were found in an egg pasta in direct contact with recycled paperboard (3.6 mg kg(-1)) and in a milk bread (3.6 mg kg(-1)).

  6. On-line tribochemical strengthening of gear surface

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    It has been found that under favorable friction conditions some antiwear elements inlubricating additives can permeate into subsurface of metal which can strengthens the friction sur-faces and improves anti-wear capacity of frication pairs. It is in many ways similar to chemical heattreatment. A new concept, technology of on-line strengthening, was logically put forward. Based oncurrent gear surface treatment technology, the on-line strengthen of gear surface is proposed. Itsdesign method is established. Based on it, the on-line strengthen of gear is achieved on CL-100gear test machine. A new method is put forward for strengthen treatment of gear surface. Andthree kinds of surface film were suggested.

  7. UAV On-line Path Re-planning Based on Threats Evaluation Improved Algorithm%基于改进威胁代价的无人机路径在线重规划

    Institute of Scientific and Technical Information of China (English)

    高晓光; 魏小丰; 郑景嵩

    2012-01-01

    针对路径在线重规划中的威胁代价评估问题,提出了基于最大综合拦截概率的在线威胁代价评估改进算法.在该算法中,以已有威胁代价评估模型为基础,给出不同信息支持条件下的“瞬时跟踪概率”计算模块,进而引入“连续跟踪概率”概念,并结合“杀伤概率”得到“拦截概率”概念模块.在此基础上,提出“最大拦截概率”概念,以此作为单个主动威胁作用下的在线威胁代价评估标准,最后将其拓展到“最大综合拦截概率”作为多个主动威胁作用下的在线威胁代价评估标准.在此基础上,结合MPC算法给出路径在线重规划的模型.通过仿真结果对比,说明上述模型的合理性和算法的有效性.%An improved threats evaluation algorithm is proposed for the on-line path re-planning of Unmanned Aerial Vehicle (UAV). Based on the existing threat evaluation model, instantaneous radar tracking probability computation modules on condition of different information is given to calculate the continuous radar tracking probability. Kill probability on condition of continuous radar tracking is proposed. As a result, interception probability and maximum interception probability are figured out to provide an evaluation criterion for a single threat, while the maximum integrated interception probability is consider as the criterion for multiple threats-Based on the threats evaluation improved algorithm, Model Predictive Control (MPC) is adopted to implement the on-line path planning. Simulation results have shown that the model is more intelligent and the approach is more effective in path re-planning.

  8. Robust on-line monitoring of biogas processes; Robusta maettekniker on-line foer optimerad biogasproduktion

    Energy Technology Data Exchange (ETDEWEB)

    Nordberg, Aake; Hansson, Mikael; Kanerot, Mija; Krozer, Anatol; Loefving, Bjoern; Sahlin, Eskil

    2010-03-15

    Although demand for biomethane in Sweden is higher than ever, many Swedish codigestion plants are presently operated below their designed capacity. Efforts must be taken to increase the loading rate and guarantee stable operation and high availability of the plants. There are currently no commercial systems for on-line monitoring, and due to the characteristics of the material, including corrosion and tearing, robust applications have to be developed. The objective of this project was to identify and study different monitoring technologies with potential for on-line monitoring of both substrate mixtures and anaerobic digester content. Based on the prerequisites and demands at Boraas Energi och Miljoe AB's (BEMAB, the municipal energy and waste utility in the city of Boraas, Sweden) biogas plant, the extent of the problems, measurement variables and possible ways of managing these issues have been identified and prioritized. The substrate mixtures in question have a high viscosity and are inhomogeneous with variation in composition, which calls for further homogenization, dilution and filtration to achieve high precision in the necessary analyses. Studies of using different mixers and mills showed that the particle size (800 mum) needed for on-line COD measurement could not be achieved. The problem of homogenization can be avoided if indirect measurement methods are used. Laboratory tests with NIR (near-infra red spectroscopy) showed that VS can be predicted (R2=0,78) in the interval of 2-9% VS. Furthermore, impedance can give a measurement of soluble components. However, impedance is not sensitive enough to give a good measurement of total TS. Microwave technology was installed at the production plant and showed a faster response to changes in TS than the existing TS-sensor. However, due to technical problems, the evaluation only could be done during a limited period of ten days. BEMAB will continue the measurements and evaluation of the instrument. The

  9. The war against on-line piracy

    OpenAIRE

    Harris, Julian

    2011-01-01

    A summary by Julian Harris, Deputy General Editor Amicus Curiae, of US attempts to control what it identifies as rogue Internet sites engaged in on-line piracy and opposition to such legislative moves.

  10. On-Line Acquisitions by LOLITA

    Directory of Open Access Journals (Sweden)

    Frances G. Spigai

    1970-12-01

    Full Text Available The on-line acquisition program (LOLITA in use at the Oregon State University Library is described in terms of development costs, equipment requirements, and overall design philosophy. In particular, the record format and content of records in the on-order file, and the on-line processing of these records (input, search, correction, output using a cathode ray tube display terminal are detailed.

  11. ACSEPP On-Line Electronic Payment Protocol

    Institute of Scientific and Technical Information of China (English)

    WANG Shao-bin; ZHU Xian; HONG Fan

    2004-01-01

    With analyzing the existing on-line electronic payment protocols, this paper presents a new on-line electronic payment protocol named ACSEPP: Anonymous, Convenient and Secure Electronic Payment Protocol.Its aim is to design a practical electronic payment protocol which is both secure and convenient.Without using PKI_CA frame, it realized the anonymity of consumer and merchant, the convenient of handling, the low cost of maintenance and the security.

  12. Repositioning of chlorambucil as a potential anti-schistosomal agent.

    Science.gov (United States)

    Eissa, Maha M; Mossallam, Shereen F; Amer, Eglal I; Younis, Layla K; Rashed, Hoda A

    2017-02-01

    As parasites and cancer cells share many lifestyle and behavioral resemblances, repositioning of anti-cancerous agents as anti-parasitic is quite trendy, especially those sharing the same therapeutic targets. Therefore, the current study investigated the in vitro efficacy of ascending concentrations of chlorambucil (0.5-20μg/ml) against adult Schistosoma mansoni worms, over 72h. Additionally, its in vivo effects against the different developmental stages of the worm were assessed, after an oral dose of 2.5mg/kg/day for five successive days, through evaluating the worm load reduction and worms' morphological alterations and oogram changes. In addition to tissue egg count, a histopathological study of the liver was conducted. In vitro, chlorambucil demonstrated noticeable anti-schistosomal effects in the form of progressive reductions of the worms' viability in a dose dependent manner. Complete worm death was achieved at 72h incubation with 5μg/ml drug concentration. In vivo, chlorambucil induced a significant reduction in the total worm load against all developmental stages. Its highest impact was evident against the juvenile stage, where it induced 75.8% total worm load reduction, and 89.2% and 86.7% intestinal and hepatic egg counts reduction, respectively, along with ogram alterations. Besides, it induced significant shortening of both male and female worms and promoted an amelioration of hepatic histopathology. Results show that chlorambucil possesses favorable in vitro and in vivo anti-schistosomal activity. The highest in vivo efficacy was against the juvenile stage of S. mansoni, significantly superior to praziquantel, with extended potency to the adult stage. Further studies are recommended for chlorambucil target verification and to enhance its therapeutic efficacy. Copyright © 2016 Elsevier B.V. All rights reserved.

  13. "Ah Mom, What's Happened to You?!" A Grounded Theory-Study about Repositioning in the Relationship Between Elderly Parents and Their Adult, Care-Giving Children

    Directory of Open Access Journals (Sweden)

    Barbara Dieris

    2006-05-01

    Full Text Available When elderly people can no longer lead independent lives their adult daughters and sons often take on an important role as caregivers. The adoption of new tasks and roles changes the parent-child relationship. This does not lead, however, to a complete role-reversal, some characteristics of the relationship and roles remain unchanged. This contribution reconstructs the changes of the parent-child relationship from the perspective of caring adult children. The methodological approach is based on Grounded Theory. I have developed a theoretical model of filial repositioning. Different change levels of acting and of relationship are described. Strategies used by parents and children are presented. Context factors concerning relationships and health status affect the process of repositioning and the strategies of parents and children. URN: urn:nbn:de:0114-fqs0603253

  14. Medición de las Actitudes de los Internautas respecto a la Compra On-Line. Segmentación en Base a Actitudes y Caracterización de los Segmentos Identificados

    Directory of Open Access Journals (Sweden)

    Lidia Andrades Caldito

    2005-03-01

    Full Text Available Internet ha introducido numerosos cambios en el contexto de los negocios, poniendo al alcance de las empresas recursos que posibilitan un mayor acercamiento y un mejor conocimiento de sus clientes actuales y potenciales. En el contexto del comercio electrónico, será primordial para las empresas entender a qué factores responde el comportamiento de los consumidores ya que, dada la especial naturaleza de esta modalidad de compra, cabe esperar que existan diferencias respecto a los modelos de comportamiento tradicionales. En este trabajo abordamos el análisis de los usuarios de Internet, tratando de determinar su predisposición hacia la compra on-line a través de la valoración de las actitudes que manifiestan hacia ella. En base a la estimación efectuada, se propone una segmentación de los individuos, y la caracterización de los segmentos hallados, identificando qué aspectos de la compra electrónica consideran más relevantes a la hora de seleccionar un establecimiento virtual.

  15. On-line Ultrasound-Assisted Dispersive Micro-Solid-Phase Extraction Based on Amino Bimodal Mesoporous Silica Nanoparticles for the Preconcentration and Determination of Cadmium in Human Biological Samples.

    Science.gov (United States)

    Shirkhanloo, H; Falahnejad, M; Zavvar Mousavi, H

    2016-06-01

    On-line ultrasound-assisted dispersive micro-solid-phase extraction (USA-DμSPE) has been developed for preconcentration and separation of trace amounts of Cd(II) ions in 0.5 mL of human biological samples. In a syringe with a nylon membrane, new synthetic bulky amino bimodal mesoporous silica nanoparticles (NH2-UVM7) were dispersed as a nanoadsorbent in 5 mL of diluted serum sample (1:10), and after ultrasonic shaking, the liquid phase was separated from the solid phase. At the optimized pH, the chemical and physical adsorption of cadmium ions occurred, respectively, based on complexation with amine groups of UVM7 (Cd:NH2-UVM7) and silica nanoparticles. The analyte was then back-extracted from the sorbent with nitric acid solution (0.2 M), and its concentration was determined by electrothermal atomic absorption spectrometry (ETAAS). Under the optimized conditions, the linear range, limit of detection (LOD), and preconcentration factor (PF) were obtained as 0.01-0.56 μg L(-1), 0.002 μg L(-1), and 25, respectively. The adsorption capacity of NH2-UVM7 was found to be 108.6 mg g(-1) of cadmium. The validation of the methodology was performed by the human standard reference material (HSRM).

  16. 5th Computer Science On-line Conference

    CERN Document Server

    Senkerik, Roman; Oplatkova, Zuzana; Silhavy, Petr; Prokopova, Zdenka

    2016-01-01

    This volume is based on the research papers presented in the 5th Computer Science On-line Conference. The volume Artificial Intelligence Perspectives in Intelligent Systems presents modern trends and methods to real-world problems, and in particular, exploratory research that describes novel approaches in the field of artificial intelligence. New algorithms in a variety of fields are also presented. The Computer Science On-line Conference (CSOC 2016) is intended to provide an international forum for discussions on the latest research results in all areas related to Computer Science. The addressed topics are the theoretical aspects and applications of Computer Science, Artificial Intelligences, Cybernetics, Automation Control Theory and Software Engineering.

  17. On-Line Impact Load Identification

    Directory of Open Access Journals (Sweden)

    Krzysztof Sekuła

    2013-01-01

    Full Text Available The so-called Adaptive Impact Absorption (AIA is a research area of safety engineering devoted to problems of shock absorption in various unpredictable scenarios of collisions. It makes use of smart technologies (systems equipped with sensors, controllable dissipaters and specialised tools for signal processing. Examples of engineering applications for AIA systems are protective road barriers, automotive bumpers or adaptive landing gears. One of the most challenging problems for AIA systems is on-line identification of impact loads, which is crucial for introducing the optimum real-time strategy of adaptive impact absorption. This paper presents the concept of an impactometer and develops the methodology able to perform real-time impact load identification. Considered dynamic excitation is generated by a mass M1 impacting with initial velocity V0. An analytical formulation of the problem, supported with numerical simulations and experimental verifications is presented. Two identification algorithms based on measured response of the impacted structure are proposed and discussed. Finally, a concept of the AIA device utilizing the idea of impactometer is briefly presented.

  18. SOL: INNOVACIÓN ON-LINE

    Directory of Open Access Journals (Sweden)

    Rubén Faúndez

    2007-11-01

    Full Text Available Las aplicaciones de simulación tienden a ser cada vez más cercanas a usuarios e industrias. Sin embargo, muchas de ellas no poseen ni la capacidad ni el conocimiento como para desarrollar internamente sus modelos de simulación. Por este motivo, y como una forma de apoyar la toma de decisiones basándose en modelos de simulación, se presenta la plataforma SOL (Simulación On Line. La metodología completa de trabajo, así como la interacción entre SOL, Empresa y Asesor, son presentadas. Su base de datos, los niveles de usuarios, sus funcionalidades, y la creación automatizada de información grafica y visual, también son explicadas. En el caso de aplicación, el uso de SOL para apoyar la toma de decisiones en una operación de movimiento de material, permite a los tomadores de decisión acceder a análisis robustos basados en información extraída de los modelos de simulación. SOL, al almacenar información, funcionar vía web, generar análisis automatizados y crear visualizaciones, permite cumplir con las expectativas de los usuarios respecto a una solución integral en simulación.

  19. Reduced pressure for fewer pressure ulcers: can real-time feedback of interface pressure optimise repositioning in bed?

    Science.gov (United States)

    Gunningberg, Lena; Carli, Cheryl

    2016-10-01

    The aim of this study was to (i) describe registered nurses' and assistant nurses' repositioning skills with regard to their existing attitudes to and theoretical knowledge of pressure ulcer (PU) prevention, and (ii) evaluate if the continuous bedside pressure mapping (CBPM) system provides staff with a pedagogic tool to optimise repositioning. A quantitative study was performed using a descriptive, comparative design. Registered nurses (n = 19) and assistant nurses (n = 33) worked in pairs, and were instructed to place two volunteers (aged over 70 years) in the best pressure-reducing position (lateral and supine), first without viewing the CBPM monitor and then again after feedback. In total, 240 positionings were conducted. The results show that for the same person with the same available pressure-reducing equipment, the peak pressure varied considerably between nursing pairs. Reducing pressure in the lateral position appeared to be the most challenging. Peak pressures were significantly reduced, based on visual feedback from the CBPM monitor. The number of preventive interventions also increased, as well as patients' comfort. For the nurses as a group, the knowledge score was 59·7% and the attitude score was 88·8%. Real-time visual feedback of pressure points appears to provide another dimension to complement decision making with respect to PU prevention. © 2014 The Authors. International Wound Journal © 2014 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

  20. Systematic drug repositioning for a wide range of diseases with integrative analyses of phenotypic and molecular data.

    Science.gov (United States)

    Iwata, Hiroaki; Sawada, Ryusuke; Mizutani, Sayaka; Yamanishi, Yoshihiro

    2015-02-23

    Drug repositioning, or the application of known drugs to new indications, is a challenging issue in pharmaceutical science. In this study, we developed a new computational method to predict unknown drug indications for systematic drug repositioning in a framework of supervised network inference. We defined a descriptor for each drug-disease pair based on the phenotypic features of drugs (e.g., medicinal effects and side effects) and various molecular features of diseases (e.g., disease-causing genes, diagnostic markers, disease-related pathways, and environmental factors) and constructed a statistical model to predict new drug-disease associations for a wide range of diseases in the International Classification of Diseases. Our results show that the proposed method outperforms previous methods in terms of accuracy and applicability, and its performance does not depend on drug chemical structure similarity. Finally, we performed a comprehensive prediction of a drug-disease association network consisting of 2349 drugs and 858 diseases and described biologically meaningful examples of newly predicted drug indications for several types of cancers and nonhereditary diseases.

  1. Poss On-line (Personalisation of Self-Service Solutions across On-line platforms)

    DEFF Research Database (Denmark)

    Nielsen, Janni; Nielsen, Lene; Jespersen, Mikkel

    2005-01-01

    The project on Personalisation of Self-service Solutions across On-line Platforms (POSS ON-LINE) focuses on users, clients, and self-service solutions. It is based on the understanding that clients and users are different and have different goals, and that self-service takes place in different co...... at the process of development. However, we lack methods to predict user behaviour without having to deal with huge amounts of data and data from both quantitative data as well as life world observations are required....... the client and the user. The system gathers data about the user, which enables the client to push information to the user. Personalisation enables graphic user interface design that is personalised and relevant to the individual user and invites the user to get access to information with less strain....... Personalisation of self-service solutions is promising and IT companies are experiencing an increase in the clients' demands. At the same time the development of solutions moves within a shorter and shorter time span. Hence the process of innovations is paced and there is an increasing need of new ways of looking...

  2. Correction of aortic regurgitation after transcatheter aortic valve implantation of the Medtronic CoreValveTM prosthesis due to a too-low implantation, using transcatheter repositioning.

    Science.gov (United States)

    Zahn, Ralf; Schiele, Rudolf; Kilkowski, Caroline; Klein, Bärbel; Zeymer, Uwe; Werling, Christiane; Lehmann, Andreas; Gerckens, Ulrich; Saggau, Werner

    2011-01-01

    Transcatheter aortic valve implantation (TAVI) has been introduced for the treatment of severe symptomatic aortic stenosis in patients not suitable for surgical valve replacement. However, a potential problem of TAVI is the development of severe aortic insufficiency after valve implantation due to a too-low implantation of the valve. Since August 2008, a total of 33 TAVI procedures using the 18 Fr Medtronic CoreValve ReValving system has been performed at the authors' institution. Severe post-implantation aortic regurgitation occurred in three patients (9%), due to a too-low implantation. Two of these patients underwent a catheter-based repositioning of the valve using a standard snare; the third patient declined any further intervention. Both repositioning procedures were uneventful, with no significant residual regurgitation. Severe aortic regurgitation after TAVI with the Medtronic CoreValve system is not uncommon. If the valve is implanted too low, a catheter-based valve repositioning may be the method of choice to resolve the problem.

  3. ADAPTIVE CONTEXT PROCESSING IN ON-LINE HANDWRITTEN CHARACTER RECOGNITION

    NARCIS (Netherlands)

    Iwayama, N.; Ishigaki, K.

    2004-01-01

    We propose a new approach to context processing in on-line handwritten character recognition (OLCR). Based on the observation that writers often repeat the strings that they input, we take the approach of adaptive context processing. (ACP). In ACP, the strings input by a writer are automatically

  4. The Lesson Observation On-Line (Evidence Portfolio) Platform

    Science.gov (United States)

    Cooper, David G.

    2015-01-01

    At a time when teacher training is being moved to school-based programmes it is important to engage in a research-informed dialogue about creating more distinctive, and cost-effective 21st century models of teacher training. Three years ago I began feasibility field testing the Lesson Observation On-line (Evidence Portfolio) Platform [LOOP]…

  5. On-line survivable routing in WDM networks

    NARCIS (Netherlands)

    Beshir, A.A.; Kuipers, F.A.; Van Mieghem, P.F.A.; Orda, A.

    2009-01-01

    In WDM networks, survivable routing and wavelength assignment (SRWA) involves assigning link-disjoint primary and backup lightpaths. In the on-line SRWA problem, a sequence of requests arrive and each request is either accepted or rejected based only on the input sequence seen so far. For special

  6. On-line Survivable Routing in WDM Networks

    NARCIS (Netherlands)

    Beshir, A.A.; Kuipers, F.A.; Van Mieghem, P.; Orda, A.

    In WDM networks, survivable routing and wavelength assignment (SRWA) involves assigning link-disjoint primary and backup lightpaths. In the on-line SRWA problem, a sequence of requests arrive and each request is either accepted or rejected based only on the input sequence seen so far. For special

  7. Repositioning approved drugs for the treatment of problematic cancers using a screening approach.

    Science.gov (United States)

    Varbanov, Hristo P; Kuttler, Fabien; Banfi, Damiano; Turcatti, Gerardo; Dyson, Paul J

    2017-01-01

    Advances in treatment strategies together with an earlier diagnosis have considerably increased the average survival of cancer patients over the last four decades. Nevertheless, despite the growing number of new antineoplastic agents introduced each year, there is still no adequate therapy for problematic malignancies such as pancreatic, lung and stomach cancers. Consequently, it is important to ensure that existing drugs used to treat other types of cancers, and potentially other diseases, are not overlooked when searching for new chemotherapy regimens for these problematic cancer types. We describe a screening approach that identifies chemotherapeutics for the treatment of lung and pancreatic cancers, based on drugs already approved for other applications. Initially, the 1280 chemically and pharmacologically diverse compounds from the Prestwick Chemical Library® (PCL) were screened against A549 (lung cancer) and PANC-1 (pancreatic carcinoma) cells using the PrestoBlue fluorescent-based cell viability assay. More than 100 compounds from the PCL were identified as hits in one or both cell lines (80 of them, being drugs used to treat diseases other than cancer). Selected PCL hits were further evaluated in a dose-response manner. Promising candidates for repositioning emanating from this study include antiparasitics, cardiac glycosides, as well as the anticancer drugs vorinostat and topotecan.

  8. Repositioning approved drugs for the treatment of problematic cancers using a screening approach

    Science.gov (United States)

    Kuttler, Fabien; Banfi, Damiano; Turcatti, Gerardo; Dyson, Paul J.

    2017-01-01

    Advances in treatment strategies together with an earlier diagnosis have considerably increased the average survival of cancer patients over the last four decades. Nevertheless, despite the growing number of new antineoplastic agents introduced each year, there is still no adequate therapy for problematic malignancies such as pancreatic, lung and stomach cancers. Consequently, it is important to ensure that existing drugs used to treat other types of cancers, and potentially other diseases, are not overlooked when searching for new chemotherapy regimens for these problematic cancer types. We describe a screening approach that identifies chemotherapeutics for the treatment of lung and pancreatic cancers, based on drugs already approved for other applications. Initially, the 1280 chemically and pharmacologically diverse compounds from the Prestwick Chemical Library® (PCL) were screened against A549 (lung cancer) and PANC-1 (pancreatic carcinoma) cells using the PrestoBlue fluorescent-based cell viability assay. More than 100 compounds from the PCL were identified as hits in one or both cell lines (80 of them, being drugs used to treat diseases other than cancer). Selected PCL hits were further evaluated in a dose-response manner. Promising candidates for repositioning emanating from this study include antiparasitics, cardiac glycosides, as well as the anticancer drugs vorinostat and topotecan. PMID:28166232

  9. 基于线阵扫描的有限角度投影数据CT三维重建%Limited Angle Computed Tomography Recontruction Algorithm Based on Line Scanning

    Institute of Scientific and Technical Information of China (English)

    张祥春

    2013-01-01

    通过对最小化图像总变差的优化准则的迭代重建算法的三维扩展,实现了基于GPU(图形处理器)技术的有限角度投影数据的三雏重建算法;在此基础上,通过改变扫描方式,实现了线阵探测器的有限角度投影数据的CT三维重建.试验表明:该方法可有效实现基于线阵扫描的有限角度投影数据的三维重建,是面阵列探测器有限角度投影数据CT三维重建的有力补充.%This article is to show, based on the GPU technology, how to realize limited angle projection data 3D reconstruction algorithm through the minimization of total variation image optimization criterion of iterative reconstruction algorithm for three-dimensional expansion.On the basis of this and by changing the scanning mode, the linear array detector limited angle projection data CT three-dimensional reconstruction is realized.Experiments show that the method can effectively realize the limited angle projection data reconstruction based on line scanning, and is a powerful supplement of limited angle projection data CT three-dimensional reconstruction by the surface array detector.

  10. 基于BP神经网络的金刚石涂层钻头失效在线检测%Based on BP Neural Network of Diamond Coating Drill Failure On-line Detection

    Institute of Scientific and Technical Information of China (English)

    彭广盼; 傅蔡安

    2013-01-01

    In order to find the on-line detection methods of diamond coated drill failure in the drilling process, it studied the form of diamond coated drill failure; Then research the drilling torque characteristics when the drill failure occurs. Based on the torque characteristics, we selected five parameters as neural network input, such as torque slope. We use Kistler 9277 A5 force dynamometer to detect the torque during the drilling process, with the BP neural network calculations and get the drilling drill failure model. The verification results show that the BP neural network-based detection method can effectively detect the diamond coated drill failure in the process of drilling.%为了找到金刚石涂层钻头在钻削过程中钻头失效的在线检测方法,本文对钻头失效的形式进行了分析,然后对钻头失效发生时钻削扭矩的特性进行了研究.采用Kistler 9277A5测力机来检测钻削过程的扭矩值;在分析了扭矩特性的基础上,选取扭矩斜率等5个参数作为神经网络的输入;然后通过BP神经网络的建模,得出钻削过程中钻头的失效模型.验证结果表明,本文提出的基于BP神经网络的检测方法可以有效的检测金刚石涂层钻头钻削加工过程中的失效情况.

  11. [Spondylolisthesis and pseudospondylolisthesis. Treatment by segmental reposition and interbody fusion with fixateur interne].

    Science.gov (United States)

    Kluger, P; Weidt, F; Puhl, W

    1997-09-01

    In spondylolisthesis with an indication for fusion and with a slipping of more than 50% at least a partial reposition should be reached in general because the incidence of pseudarthrosis would increase with a fusion in situ and a large disturbance of the spinal statics would persist. Hereby with almost all methods an enlarged operative morbidity and often a longer fusion range has to be taken in account compared to the fusion in situ. Therefore, in smaller slippages the fusion in situ will be favoured because the disturbance of the statics is not so important, that such an effort combined with such methods is necessary. If the operation method with small spondylolisthesis and pseudospondylolisthesis allows the reposition without much effort and if the operative morbidity in comparison with the fusion in situ is not higher, then it is reasonable to fuse the cases with a spondylolisthesis Meyerding grade 1 and 2 in the anatomic corrected position too. Because the spinal fixator we use fills out these criteria we combine the correction of the position with the fusion also in cases of small spondylolisthesis. The incidence of neurologic complications correlates with the amount of the reposition distance and can be caused by preforaminal or extraforaminal lesions. The reduction of small malpositions could only produce preforaminal lesions. Using the spine fixator with its reposition instruments linked outside the wound and with it's un-inhibited access to the segment and to the preforaminal neural structures during the whole repositioning these lesions can be avoided.

  12. Effect of proprioception cross training on repositioning accuracy and balance among healthy individuals

    Science.gov (United States)

    El-Gohary, Tarek Mohamed; Khaled, Osama Ahmed; Ibrahim, Sameh R; Alshenqiti, Abdullah M; Ibrahim, Mahmoud I

    2016-01-01

    [Purpose] To investigate possible cross effects of proprioception training on proprioception repositioning accuracy of the knee joint and on balance in healthy subjects. [Subjects and Methods] Sixty healthy college students and faculty members from faculty of physical therapy, Cairo University were recruited to participate. Participants were randomly assigned to training group (n=30) and control group (n=30). The training group received proprioceptive training program only for the dominant leg while the control group did not receive any kind of training. Outcome measures were twofold: (1) proprioception repositioning accuracy quantified through the active repositioning test for the non-dominant knee; and (2) balance stability indices determined through using Biodex balance system. Measurements were recorded before and after 8 weeks of proprioception training. [Results] There were significant decrease in the error of repositioning accuracy and the stability indices including anterposterior stability index, mediolateral stability index, and overall stability index of training group, measured post training, compared with control group. [Conclusion] Proprioception training has significant cross training effects on proprioception repositioning accuracy of the knee joint and on balance among healthy subjects. PMID:27942145

  13. Modelling the effect of repositioning on the evolution of skeletal muscle damage in deep tissue injury.

    Science.gov (United States)

    Demol, Jan; Deun, Dorien Van; Haex, Bart; Oosterwyck, Hans Van; Sloten, Jos Vander

    2013-04-01

    Deep tissue injury (DTI) is a localized area of tissue necrosis that originates in the subcutaneous layers under an intact skin and tends to develop when soft tissue is compressed for a prolonged period of time. In clinical practice, DTI is particularly common in bedridden patients and remains a serious issue in todays health care. Repositioning is generally considered to be an effective preventive measure of pressure ulcers. However, limited experimental research and no computational studies have been undertaken on this method. In this study, a methodology was developed to evaluate the influence of different repositioning intervals on the location, size and severity of DTI in bedridden patients. The spatiotemporal evolution of compressive stresses and skeletal muscle viability during the first 48 h of DTI onset was simulated for repositioning schemes in which a patient is turned every 2, 3, 4 or 6 h. The model was able to reproduce important experimental findings, including the morphology and location of DTI in human patients as well as the discrepancy between the internal tissue loads and the contact pressure at the interface with the environment. In addition, the model indicated that the severity and size of DTI were reduced by shortening the repositioning intervals. In conclusion, the computational framework presented in this study provides a promising modelling approach that can help to objectively select the appropriate repositioning scheme that is effective and efficient in the prevention of DTI.

  14. Cases requiring increased number of repositioning maneuvers in benign paroxysmal positional vertigo

    Directory of Open Access Journals (Sweden)

    Mukadder Korkmaz

    Full Text Available ABSTRACT INTRODUCTION: Benign paroxysmal positional vertigo (BPPV is a clinical syndrome that is proposed to be caused by dislocated utricular debris into semicircular canals. Although the majority of patients are treated by one or two repositioning maneuvers, some of the patients need repeated maneuvers for relief. OBJECTIVE: The goal of this study was to investigate the factors associated with patients with benign paroxysmal positional vertigo who required multiple repositioning procedures for treatment. METHODS: Data were obtained from the clinical records of 153 patients diagnosed with benign paroxysmal positional vertigo. Patients were treated by repositioning maneuvers. Demographic data and the factors including age, sex, canal type, duration of symptoms, comorbidities and number of repositioning maneuvers for relief were documented for statistical analysis. RESULTS: Age, sex, canal type and the duration of symptoms had no impact on the number of maneuvers. The most common comorbidity was spine problems. Hypertension was the only comorbidity that significantly associated with increased number of maneuvers. CONCLUSION: The presence of hypertension is a risk factor for repeated maneuvers in benign paroxysmal positional vertigo treatment. Physicians should be aware of the increased probability of repeated repositioning maneuvers in these group of patients. The role of comorbidities and vascular factors need to be further clarified in the course of benign paroxysmal positional vertigo.

  15. Long-term corneal endothelial cell changes in pediatric intraocular lens reposition and exchange cases.

    Science.gov (United States)

    Wang, Yan; Wu, Mingxing; Zhu, Liyuan; Liu, Yizhi

    2012-04-01

    To evaluate long-term corneal endothelial cell changes of intraocular lens (IOL) reposition and exchange in children. State key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China In this retrospective study, all IOL reposition and exchange procedures performed in patients under 14 years old between January 1999 and April 2009 were included. Follow-up outcomes included corneal endothelial cell density, hexagonality, coefficient of variance, average cell size. IOL reposition procedures in 12 eyes (12 cases) (reposition group, RPG), and IOL exchanges in eight eyes (eight cases) (exchange group, EXG) were performed because of IOL pupillary capture or IOL dislocation. Median of follow-up was 44.5 months in RPG and 66.2 months in EXG. The density of corneal endothelial cells in RPG (2,053 ± 493/mm(2)) and EXG (2,100 ± 758/mm(2)) was significantly decreased in comparison to the control eyes (3,116 ± 335/mm(2)). Hexagonality of corneal endothelial cells and coefficient of variance showed no difference among the control group, RPG and EXG (P > 0.05). The density of corneal endothelial cells was conspicuously decreased after IOL reposition or exchange procedures in childhood cases. Longer follow-up must be conducted in these cases.

  16. Drug Repositioning and Pharmacophore Identification in the Discovery of Hookworm MIF Inhibitors

    Energy Technology Data Exchange (ETDEWEB)

    Y Cho; J Vermeire; J Merkel; L Leng; X Du; R Bucala; M Cappello; E Lolis

    2011-12-31

    The screening of bioactive compound libraries can be an effective approach for repositioning FDA-approved drugs or discovering new pharmacophores. Hookworms are blood-feeding, intestinal nematode parasites that infect up to 600 million people worldwide. Vaccination with recombinant Ancylostoma ceylanicum macrophage migration inhibitory factor (rAceMIF) provided partial protection from disease, thus establishing a 'proof-of-concept' for targeting AceMIF to prevent or treat infection. A high-throughput screen (HTS) against rAceMIF identified six AceMIF-specific inhibitors. A nonsteroidal anti-inflammatory drug (NSAID), sodium meclofenamate, could be tested in an animal model to assess the therapeutic efficacy in treating hookworm disease. Furosemide, an FDA-approved diuretic, exhibited submicromolar inhibition of rAceMIF tautomerase activity. Structure-activity relationships of a pharmacophore based on furosemide included one analog that binds similarly to the active site, yet does not inhibit the Na-K-Cl symporter (NKCC1) responsible for diuretic activity.

  17. On-line comprehensive monitoring application for power transmission line based on GPRS and ZigBee technology%ZigBee技术和GPRS在输电线路在线监测中的应用

    Institute of Scientific and Technical Information of China (English)

    刘成印; 刘伟; 何凯

    2012-01-01

    针对高压输电线路的分散性大,所处地理环境、气候条件复杂的现状,以实际项目开发为背景,设计了一套以GPRS和ZigBee无线传感器网络技术为基础的输电线路综合监测系统。该系统中由传感器节点采集导线拉力、倾角和气象等信息,由ZigBee无线传感器网络传输到监测子站系统进行数据融合处理,并通过GPRS公网把数据传回主站监测系统。文中详细阐述监测子站和无线传感器节点模块的硬件结构,以及导线弧垂在线监测装置的工作原理,给出主站系统、子站系统的软件工作流程。该系统经实际运行测试,结果表明:基于ZigBee技术的输电线路综合监测系统具有良好的可扩展性、可靠性,功耗较低,维护方便,是目前行之有效的方法,完全可以满足输电系统在线监测的需要。%Aimed at addressing the larger dispersion of the high-voltage transmission lines and more complicated geographical environment and climatic conditions to which these lines are exposed,this paper designs a set of on-line comprehensive monitoring system for power transmission line based on GPRS and ZigBee technology.The system works by enabling sensor nodes to obtain the information associated with wire tension,dip Angle and weather,which are transferred to sub-station monitoring system by wireless sensor networks for data fusion process before the substation system transfers these fused data to mainstation system by GPRS wireless public network.The paper details the hardware structure and software process of main station system,sub-station system and sensor nodes.The power transmission line monitoring system based on ZigBee technology boasts such advantages as a greater scalability,more reliable performance,lower power consumption,and easier maintenance and thus works as an effective method quite up to the needs of power transmission system for on-line monitoring.

  18. 基于广域测量系统的电压稳定指标%A On-Line Voltage Stability Index Based on Wide Area Measurement System

    Institute of Scientific and Technical Information of China (English)

    巩伟峥; 房鑫炎

    2011-01-01

    综述和比较了多种基于广域测量的在线电压静态稳定指标,通过理论分析指出了这几种指标的理论缺陷和使用限制.利用同步测量的母线电压相量、线路潮流等电气量,根据线路潮流电压方程计算比较线路两侧电压水平,提出了一种新的电压稳定性指标Ivs,指示被监测线路或母线的电压稳定情况.通过系统等效的方法解耦多机系统的线路电压耦合性,可将该指标推广到多机系统.在单机单负荷系统和IEEE 14节点系统的仿真表明,Ivs可以准确快速地判断系统线路电压稳定情况,预测线路电压失稳点,且适用于所有种类的线路.与之前的电压静态稳定指标相比,Ivs具有无需判断线路电阻,物理概念清晰,适用范围广,线性度好等优点,有利于实现在线电压稳定监测和评估.%On-line steady state voltage stability indices based on wide area measurement system (WAMS) are summarized and compared. Based on theoretical analysis, the theoretical defects and usage limitations of these indices are pointed out. Utilizing synchronously measured electric quantities such as bus voltage phasors and line power flows and according to the comparison results of voltage levels, which are calculated by power flow and voltage equations of transmission line, at both terminals oftransmission lines, a new voltage stability index Ivs is proposed to indicate the voltage stability condition of monitored bus or transmission line. By means of system equivalence, the coupling of line voltage in multi-machine power system is decoupled, thus the proposed voltage stability index can be applied to multi-machine power system. Simulation results fiom single-machine single-load system and IEEE 14-bus system show that voltage stability condition of transmission line can be rapidly judged and the voltage instability point can be predicted by the proposed index IVS, and the proposed index is suitable to all kinds of transmission

  19. 基于激光二维散射原理在线测量表面粗糙度%On-line Measurement of Surface Roughness Based on Laser Two-dimensional Scattering Principle

    Institute of Scientific and Technical Information of China (English)

    张秋佳; 赵玉华; 韩冬; 余平; 刘明珠

    2011-01-01

    Referring to the complicated operating and bad field measuring of existing surface roughness, an on-line measurement method is presented based on laser two-dimensional scattering principle. The method proposed can not only measure the surface roughness parameters, but also figure out the surface topography. In this measurement, by using non-diffraction laser beam as light source and high accuracy CCD camera as displacement sensor, and applying the method of signal processing of surface roughness by Matlab, real-time measurement of surface roughness can be realized.This method is realized with modularized design, and has the advantages of simple structure, powerful real-time processing capability, high-precision measurement, visual display, and easy operation, etc.%针对现有零件表面粗糙度测量仪器操作复杂,现场测量能力差的问题,提出一种基于激光二维散射的在线测量方法,该方法不仅可以测量表面粗糙度的统计参数,而且可以反映出表面纹理的形貌特征.在测量中,用无衍射激光光束作光源,用高精度的CCD摄像机作位移传感器,利用Matlab进行表面粗糙度测量数据采集与处理,使表面粗糙度在线检测成为可能.该方法运用模块化设计,具有结构简单、实时处理能力强、测试精度高、显示结果直观、不会划伤被测件等优点.

  20. A Brief Introduction of On-Line Analytical Processing Based On Data Warehouse of Gas Card Data%面向加油卡数据仓库的联机分析处理的探讨

    Institute of Scientific and Technical Information of China (English)

    陆瑞明

    2015-01-01

    对于石油销售企业来说,每天企业下属各加油站加油卡的使用都在不断产生交易数据,如何对这些海量数据进行有效挖掘处理成了目前业界的研究热点。本文则为关于加油卡大数据应用提供了一种业界最流行的方法:首先搭建一个数据存储系统,称为数据仓库,能存储海量历史数据;然后,在数据仓库的基础上,引入联机分析处理(OLAP),根据业务部门的不同需求给出各自所需的结果,也供企业高层管理人员进行决策使用。%Transaction data from gas cards are being created and collected continuously everyday at every gas station, which makes it very important to study on how to manage those massive data efficiently. This paper proposes a popular application of big data analysis on massive gas card transaction data: at first, building a data storage system, called Data Warehouse, to store large amounts of historical transaction data; secondly, introducing the On-Line Analytical Processing (OLAP) based on the Data Warehouse. OLAP allows users to extract different kinds of information from the raw data that meets their own needs for either research studies or enterprise decision making purpose.

  1. 基于“互联网+”的餐饮油烟在线监控系统%Application of Catering Fume Monitoring System On-line Based on “Internet +”

    Institute of Scientific and Technical Information of China (English)

    姬红波; 朱海飞

    2016-01-01

    油烟排放达标主要取决于净化设备的运行情况,是餐饮油烟监管和治理的关键。文章介绍了基于“互联网+”的餐饮油烟在线监控系统,可实时监测餐饮企业的油烟净化器的开关状态、净化器清洁度、风机开关状态、净化后的油烟排放浓度等数据。结合APP应用的移动终端和便携油烟检测设备可以实现对餐饮油烟的区域整体监控、预警、信息管理及现场移动执法检查,为环保部门对餐饮油烟的长效管理提供平台支持及执法依据。%This article describes the catering fume monitoring system on-line based on the “internet +”. The system can monitor the switching state, cleanliness of puriifers, switch state of fan, and the fume emission concentration data at real time after puriifcation. It can also realizes the overal monitoring, early warning, information management and mobile enforcement of the catering fume in combination with the APP mobile terminals and portable fume detection equipment.

  2. Efficiently Building On-line Tools for Distributed Heterogeneous Environments

    Directory of Open Access Journals (Sweden)

    Günther Rackl

    2002-01-01

    Full Text Available Software development is getting more and more complex, especially within distributed middleware-based environments. A major drawback during the overall software development process is the lack of on-line tools, i.e. tools applied as soon as there is a running prototype of an application. The MIMO MIddleware MOnitor provides a solution to this problem by implementing a framework for an efficient development of on-line tools. This paper presents a methodology for developing on-line tools with MIMO. As an example scenario, we choose a distributed medical image reconstruction application, which represents a test case with high performance requirements. Our distributed, CORBA-based application is instrumented for being observed with MIMO and related tools. Additionally, load balancing mechanisms are integrated for further performance improvements. As a result, we obtain an integrated tool environment for observing and steering the image reconstruction application. By using our rapid tool development process, the integration of on-line tools shows to be very convenient and enables an efficient tool deployment.

  3. On-Line NDE for Advanced Reactor Designs

    Science.gov (United States)

    Nakagawa, N.; Inanc, F.; Thompson, R. B.; Junker, W. R.; Ruddy, F. H.; Beatty, J. M.; Arlia, N. G.

    2003-03-01

    This expository paper introduces the concept of on-line sensor methodologies for monitoring the integrity of components in next generation power systems, and explains general benefits of the approach, while describing early conceptual developments of suitable NDE methodologies. The paper first explains the philosophy behind this approach (i.e. the design-for-inspectability concept). Specifically, we describe where and how decades of accumulated knowledge and experience in nuclear power system maintenance are utilized in Generation IV power system designs, as the designs are being actively developed, in order to advance their safety and economy. Second, we explain that Generation IV reactor design features call for the replacement of the current outage-based maintenance by on-line inspection and monitoring. Third, the model-based approach toward design and performance optimization of on-line sensor systems, using electromagnetic, ultrasonic, and radiation detectors, will be explained. Fourth, general types of NDE inspections that are considered amenable to on-line health monitoring will be listed. Fifth, we will describe specific modeling developments to be used for radiography, EMAT UT, and EC detector design studies.

  4. Predictability and accuracy of maxillary repositioning during bimaxillary surgery using a three-dimensional positioning technique.

    Science.gov (United States)

    Kokuryo, Shinya; Habu, Manabu; Miyamoto, Ikuya; Uehara, Masataka; Kodama, Masaaki; Iwanaga, Kenjiro; Yoshioka, Izumi; Tominaga, Kazuhiro

    2014-08-01

    The purpose of this retrospective study was to evaluate the predictability and accuracy of maxillary repositioning during bimaxillary surgery using a three-dimensional positioning technique. Twenty-six adult patients who underwent bimaxillary surgery requiring high superior maxillary impactions were divided into 2 groups. In group A, a three-dimensional positioning technique during maxillary repositioning was used along with an intermediate occlusal splint. In group B, only an intermediate occlusal splint with internal reference points was used. Both groups had measurements from predictive tracings compared to postoperative cephalograms to assess the accuracy of horizontal and vertical movements of the maxilla. Group A showed excellent correlation between the planned and actual maxillary positions in vertical and horizontal dimensions. In group B, the maxilla tended to move anteriorly than planned. Use of the three-dimensional positioning technique offered a predictive and accurate method for maxillary repositioning. Copyright © 2014 Elsevier Inc. All rights reserved.

  5. Preliminary application of virtual simulation and reposition template for zygomatico-orbitomaxillary complex fracture.

    Science.gov (United States)

    Li, Peng; Tang, Wei; Li, Jia; Tian, Dong W

    2012-09-01

    This report introduced and evaluated our computer-assisted surgical method in the treatment of complex maxillofacial fractures. One patient with zygomatico-orbitomaxillary complex fracture underwent computed tomography to obtain DICOM data. Three-dimensional reconstruction and virtual surgical planning were carried out in the software MIMICS 10.01. Three reposition templates and 1 skull model were manufactured in our three-dimensional rapid prototyping machine. Reconstruction surgery was carried out according to the preoperative planning and with the guide of reposition templates. At 3-month follow-up, the treatment outcome was consistent with preoperative planning exactly, and the patient expressed high satisfaction with the surgery. Combination of reposition templates and rapid prototyping method demonstrated great practical value in complex maxillofacial fracture surgery.

  6. Calmodulin regulates the post-anaphase reposition of centrioles during cytokinesis

    Institute of Scientific and Technical Information of China (English)

    Yue Yue YU; Gu DAI; Fei Yan PAN; Jie CHEN; Chao Jun LI

    2005-01-01

    A transient postanaphase repositioning of the centriole is found to control the completion of cytokinesis.Using a green fluorescent protein-calmodulin fusion protein as a living cell probe,we have previously found that calmodulin is associated with the initiation and progression of cytokinesis.In this study,we further studied the effect of calmodulin on the repositioning of the centriole and subsequent cell cycle progression.When activity of calmodulin is inhibited,the regression of the centriole from the intercellular bridge to the cell center is blocked,and thus the completion of cell division is repressed and two daughter cells are linked by longer cell bridge in perturbed cells.W7 treatment during cytokinesis also results in unfinished cytokinesis and stopped G1 phase.These results suggest that calmodulin activity is required for centriole repositioning and can affect the completion of cytokinesis and cell cycle progression.

  7. On line routing per mobile phone

    DEFF Research Database (Denmark)

    Bieding, Thomas; Görtz, Simon; Klose, Andreas

    2009-01-01

    . Additionally it is of utmost importance that the employed communication system is suitable integrated with the firm’s enterprise application system and business processes. On basis of a case study, we describe in this paper a system that is cheap and easy to implement due to the use of simple mobile phones......On-line routing is concerned with building vehicle routes in an ongoing fashion in such a way that customer requests arriving dynamically in time are efficiently and effectively served. An indispensable prerequisite for applying on-line routing methods is mobile communication technology...

  8. IOOS Data Portals and Uniform On-line Browse Capabilities

    Science.gov (United States)

    Howard, M.; Currier, R. D.; Kobara, S.; Gayanilo, F.

    2015-12-01

    The Gulf of Mexico Coastal Ocean Observing System Regional Association (GCOOS-RA) is one of eleven Regional Associations organized under the NOAA-led U.S. Integrated Ocean Observing System (IOOS) Program Office. Each of the RAs operate standards-based regional data portals designed to aggregate near real-time and historical observed data and modeled outputs from distributed providers and to offer these and derived products in standardized ways to a diverse set of users. The RA's portals are based on the IOOS Data and Communications Plan which describes the functional elements needed for an interoperable system. One of these elements is called "Uniform On-line Browse" which is an informational service designed primarily to visualize the inventory of a portal. An on-line browse service supports the end user's need to discover what parameters are available, to learn the spatial and temporal extend of the holdings, and to examine the character of the data (e.g, variability, gappiness, etc). These pieces of information help the end user decide if the data are fit for his/her purpose and to construct valid data requests. Note that on-line browse is a distinctly different activity than data analysis because it seeks to yield knowledge about the inventory and not about what the data mean. "Uniform" on-line browse is a service that takes advantage of the standardization of the data portal's data access points. Most portals represent station locations on a map. This is a view of the data inventory but these plots are rarely generated by pulling data through the standards-based services offered to the end users but through methods only available to the portal programmers. This work will present results of Uniform On-line browse tools developed within GCOOS-RA and their applicability to other RA portals.

  9. On-line monitoring and tracking of multi-mode vibration signals based on SSI and PF%基于粒子滤波的多模态振动信号在线跟踪

    Institute of Scientific and Technical Information of China (English)

    叶庆卫; 袁德彬; 武冬星; 周宇

    2013-01-01

    针对多模态振动信号的在线监测和跟踪,提出基于随机子空间(SSI)和粒子滤波(PF)算法的仿真振动信号在线监测和跟踪方法.通过SSI算法提取得到振动系统的模态主频和阻尼比,根据振动系统模型模态主频和阻尼比的计算公式,得到系统的状态矩阵和输出矩阵.将计算所得状态矩阵和输出矩阵代入状态方程,利用PF算法进行信号的在线监测和跟踪,实现信号的降噪处理和预测分析.对于大型机械、桥梁等建筑物,对其进行在线监测保障其正常营运对社会经济发展具有深远影响.利用SSI算法提取系统的模态参数,进一步构建振动系统的状态矩阵和输出矩阵,并利用PF算法进行信号滤波抑噪和预测,在此基础上可以对结构状态实施在线监测及预警控制,实际大桥斜拉索振动信号测试也表明该算法可以提供稳定可靠的信号跟踪与预测技术.%Aiming at on-line monitoring and tracking of multi-mode vibration signals, a simulation method for online monitoring and tracking of vibration signals based on stochastic subspace identification (SSI) and particle filter (PF) techniques was proposed. Using SSI technique, the modal frequencies and damping ratios of a vibration system were extracted. Then, with the formulas of these modal frequencies and damping ratios, the state matrix and output one of the system could be obtained. Substituting these two matrices into the state equations of the vibration system, its vibration signals' filtering, denoising and predicting were performed with PF technique. Afterward, the on-line monitoring and early warning control for the state of the system could be conducted. The inclined cables' vibration signal measurement of a bridge indicated that the proposed method can provide a reliable and stable method for signal tracking and predicting.

  10. 基于PAC&GPRS的高压直流开关振荡回落参数在线监测系统%On-line monitoring system of HVDC breaker based on PAC and GPRS

    Institute of Scientific and Technical Information of China (English)

    金涛; 蔡超; 王俊; 阮玲

    2013-01-01

    针对传统的离线式高压直流开关监测方法的诸多不足,为了能够实时地掌握直流开关的振荡回路的工作状态,在线计算出高压直流开关的状态参数,提出一种基于PAC(Programmable Automation Controller)和GPRS(General Packet Radio Service)的高压直流开关的在线监测方法.该方法通过采用霍尔传感器将振荡回路的振荡电流信号线性转换为电压信号,再通过PAC高数采样模块采集该电压信号,将采集到的振荡信号在本地存储之后再通过GPRS无线传输技术将采集到的数据传回后台数据处理中心,后台数据处理中心在线处理分析数据,得出RLC的参数值.实验室和葛洲坝换流站的实验表明,该系统对电力系统运行无任何影响,同时该系统能够准确地、高精度地采集振荡信号,正确地计算出振荡回路RLC参数,为准确获取高压直流开关的工作状态提供有利基础.%In order to get the real-time operating state of the oscillation circuit of the high voltage direct circuit (HVDC) breaker,and calculate the RLC parameters of the oscillation circuit,an on-line monitoring system of HVDC breaker's oscillation circuit is put forward based on the programmable automation controller (PAC) data acquisition technique.The hardware and software are designed to achieve this goal.In this system,a Hall sensor is used to linearly transform the oscillation current into voltage signal; then the voltage is gathered by PAC data acquisition system; after stored on local disk of PAC,the data is transmitted to the data processing center.After these,the RLC parameters of the oscillation circuit could be calculated automatically.With this on-line monitoring system of DC breaker's oscillation circuit,we have done experiments in our laboratory and in Gezhouba convertor station.The experimental data prove that this system does not have any impact on the electric power system; the most important is that it can accurately acquire

  11. ON-LINE DOCUMENTS CONTENT MANAGEMENT

    Directory of Open Access Journals (Sweden)

    VASILESCU RAMONA VIOLETA

    2010-05-01

    Full Text Available This paper outlines the steps and technologies used in developing an on-line application server with many desktop clients, and with high power processing for a wide range of input documents to obtain searchable documents on the highest portability standards, PDF and PDF /A.

  12. On-line quality management of ready-mixed concrete industry based on cloud computing%基于云计算的预拌混凝土行业在线质量管理

    Institute of Scientific and Technical Information of China (English)

    曾强; 余佳蓓; 许杰淋; 吉旭

    2014-01-01

    以实现质量的科学化管理和实时的动态监测为目的,提出了预拌混凝土行业基于云计算的在线质量管理。通过分析预拌混凝土企业包括经营数据和生产实时数据等大量数据的存储、整合、分析、挖掘、利用等方面需求,以云计算为平台,运用人工智能( AI)相关算法,实现了基于实际生产过程的质量预测,为解决影响混凝土强度及工作性能的多组分因素问题提供了思路和方法。提取云平台上的生产实时数据进行模拟实验,以C35的28天抗压强度为例,用1000组数据对网络进行训练,用100组数据对已训练的网络进行检验,结果证明了预测值的准确性,同时也验证了平台的可行性。%To achieve the goal of scientific quality management and real-time dynamic monitoring, the on-line quality management based on cloud computing of ready-mixed concrete was put forward. The demand of storage, integration, analysis, mining and utilizing of massive data produced during business activities and real-time production process was analyzed. Based on cloud computing platform, the quality of concrete was predicted successively using Artificial Intelligence ( AI) algorithm, providing ideas and methods to solve multi-factor problems that influence concrete compressive strength and working performance. Simulation experiment was conducted by extracting real-time production data of the 28-day compressive strength of C35 from the cloud computing platform. One thousand groups of data were used to train the original network, another 100 sets of data were used to test the validity of the trained network. The results show the accuracy of the prediction as well as the feasibility of the platform.

  13. On-line fuzzy logic control of tube bending

    Science.gov (United States)

    Lieh, Junghsen; Li, Wei Jie

    2005-11-01

    This paper describes the simulation and on-line fuzzy logic control of tube bending. By combining elasticity and plasticity theories, a conventional model was developed. The results from simulation were compared with those obtained from testing. The experimental data reveal that there exists certain level of uncertainty and nonlinearity in tube bending, and its variation could be significant. To overcome this, a on-line fuzzy logic controller with self-tuning capabilities was designed. The advantages of this on-line system are (1) its computational requirement is simple in comparison with more algorithmic-based controllers, and (2) the system does not need prior knowledge of material characteristics. The device includes an AC motor, a servo controller, a forming mechanism, a 3D optical sensor, and a microprocessor. This automated bending machine adopts primary and secondary errors between the actual response and desired output to conduct on-line rule reasoning. Results from testing show that the spring back angle can be effectively compensated by the self- tuning fuzzy system in a real-time fashion.

  14. On-line EM algorithm for the normalized gaussian network.

    Science.gov (United States)

    Sato, M; Ishii, S

    2000-02-01

    A normalized gaussian network (NGnet) (Moody & Darken, 1989) is a network of local linear regression units. The model softly partitions the input space by normalized gaussian functions, and each local unit linearly approximates the output within the partition. In this article, we propose a new on-line EMalgorithm for the NGnet, which is derived from the batch EMalgorithm (Xu, Jordan, &Hinton 1995), by introducing a discount factor. We show that the on-line EM algorithm is equivalent to the batch EM algorithm if a specific scheduling of the discount factor is employed. In addition, we show that the on-line EM algorithm can be considered as a stochastic approximation method to find the maximum likelihood estimator. A new regularization method is proposed in order to deal with a singular input distribution. In order to manage dynamic environments, where the input-output distribution of data changes over time, unit manipulation mechanisms such as unit production, unit deletion, and unit division are also introduced based on probabilistic interpretation. Experimental results show that our approach is suitable for function approximation problems in dynamic environments. We also apply our on-line EM algorithm to robot dynamics problems and compare our algorithm with the mixtures-of-experts family.

  15. CLINICAL OBSERVATION ON THE THERAPEUTIC EFFECT OF ACUPUNCTURE PLUS MANUAL REPOSITION FOR TREATMENT OF ACUTE LUMBAR VERTEBRAL ARTICULAR DYSKINESIA

    Institute of Scientific and Technical Information of China (English)

    骆钧梵

    2003-01-01

    Objective: To observe the therapeutic effect of acupuncture plus manual reposition for treatment of acute lumbar vertebral articular dyskinesia for choosing a better remedy. Methods: 66 cases of acute lumbar vertebral articular dyskinesia were randomly divided into acupuncture plus manual reposition group (treatment group, n= 33) and routine manual reposition group (control group, n = 33). Yaotong-point was punctured, when, the patient was asked to move his or her waist simultaneously. Results: After one session of treatment, of the two 33 cases in treatment and control groups, 28 (84.85%) and20 (60.61%) were cured, 4 (12.12%) and 9 (27.27%) were improved, and 1 (3.03%) and 4 (12.12%) failed in the treatment. The therapeutic effect of treatment group was significantly superior to that of control group ( P< 0.05). Conclusion: Acupuncture combined with manual reposition is apparently superior to simple routine manual reposition in relieving acute lumbar vertebral articular dyskinesia.

  16. On-line diagnosis of high power motors based on ultra wide band partial discharge detection; Diagnostico en linea de motores de gran capacidad mediante la deteccion de descargas parciales utilizando tecnicas de banda ultra ancha

    Energy Technology Data Exchange (ETDEWEB)

    Carvajal M, F. Antonio; Garcia Colon H, Vicente R. [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico); Asiain, Tomas [Instituto Politecnico Nacional, Escuela Superior de Ingenieria Mecanica y Electrica (Mexico)

    2009-07-01

    In this work a non-standardized method for on-line diagnostic of high capacity motors based on Ultra Wide Band (UWB) Partial Discharge (PD) measuring techniques is theoretically supported, implemented and applied. The method developed is non invasive and consist in the measurement of PD in the main motor power supply cables and its ground shields connection using a near field sensor (Rogowski coil, clamp-on type) with a bandwidth of 2 to 40 MHz. The measured signals by the sensor, are stretched electronically, digitized and fed to a conventional Partial Discharge digital detector. The UWB PD detection system used displays the output in a Pulse repetition frequency-Charge-Phase angle (N-Q-?) PD pattern. The results obtained in thirteen 2500 H.P., 13.8 kV motors performed during operating in an Oil Pumping facility are presented, including its analysis and comparison with values and PD patterns reported in literature. [Spanish] En este trabajo se presentan los fundamentos teoricos, la implementacion y aplicacion de un metodo no normalizado, para el diagnostico en linea de motores de gran capacidad, basado en la deteccion de Descargas Parciales (DP) utilizando tecnicas de medicion de Banda Ultra Ancha. El metodo desarrollado es no invasivo y consiste en la medicion de las DP en los conductores y conexiones a tierra de la pantalla de los cables principales de suministro de energia al motor, utilizando un sensor de campo cercano (bobina Rogowski, tipo gancho) cuyo ancho de banda de medicion es de 2 a 40 MHz. Las senales medidas por el sensor son electronicamente procesadas para ampliar su duracion, digitalizadas y enviadas a un detector digital de Descargas Parciales convencional. El sistema de deteccion de DP en Banda Ultra Ancha despliega la medicion en un patron de DP tipo frecuencia de repeticion de Pulso-Carga-Angulo de fase (N-Q-?). Se presentan los resultados obtenidos de la evaluacion en linea de trece motores de 2500 C.P. a 13.8 kV, instalados y operando en una

  17. On-Line Monitoring System for Insulator Salt Density Based on Optical Fiber Sensing Technology and Its Application%绝缘子盐密在线监测系统及其应用

    Institute of Scientific and Technical Information of China (English)

    骆东松; 黄靖梅

    2013-01-01

    The optical field distribution theory of optical waveguide was introduced based on the feasibility study of the optical fiber sensor to measure the external insulation pollution degree of the transmission and transformation power equipment.The light energy parameters of quartz glass used as the optical sensor was analyzed by spectral data analysis algorithm and the corresponding relationship between luminous flux attenuation and salt density was set up.Subsequently the optical sensor Pollution Monitoring System was developed to realize the on-line monitoring of insulator salt density.The system has already been applied in Tianshui 330 kV transmission line and the results are satisfied.The test results indicate that the system can timely and accurately monitor the salt density of the transmission and distribution equipment,and guide the production department to clean the transmission and distribution equipment in order to avoid excessive or insufficient maintenance.%基于光纤传感器测量输变电设备外绝缘污秽度的可行性研究,引入了光波导中的光场分布理论.通过光谱数据分析算法,分析了石英玻璃作为光传感器的各种光能特性,建立了光通量的衰减与盐密间的数学模型,进而研制了基于光传感器的污秽在线监测系统,实现对绝缘子盐密的在线监测.该系统已在天水330 kV输电线路陇西1-2线瓷绝缘子和复合绝缘子测点挂网运行,并取得了良好的监测效果.试验结果表明,该系统能实时、准确地监测输变电设备的盐密值,掌握输变电设备的积污规律,进而指导生产部门对输变电设备的状态清扫.以避免过度检修和检修不足的状况.

  18. Designing effective on-line continuing medical education.

    Science.gov (United States)

    Zimitat, Craig

    2001-03-01

    The Internet, and new information and communication technologies available through the Internet, provides medical educators with an opportunity to develop unique on-line learning environments with real potential to improve physicians' knowledge and effect change in their clinical practice. There are approximately 100 websites offering on-line CME courses in the USA alone. However, few of these CME courses appear to be based on sound educational principles or CME research and may have little chance of achieving the broader goals of CME. The majority of these courses closely resemble their traditional counterparts (e.g. paper-based books are now electronic books) and appear to be mere substitutions for old-technology CME resources. Whilst some CME providers add unique features of the Internet to enrich their websites, they do not employ strategies to optimize the learning opportunities afforded by this new technology. The adoption of adult learning principles, reflective practice and problem-based approaches can be used as a foundation for sound CME course design. In addition, knowledge of Internet technology and the learning opportunities it affords, together with strategies to maintain participation and new assessment paradigms, are all needed for developing online CME. We argue for an evidence-based and strategic approach to the development of on-line CME courses designed to enhance physician learning and facilitate change in clinical behaviour.

  19. On-line Dynamic Security Assessment in Power Systems

    DEFF Research Database (Denmark)

    Weckesser, Johannes Tilman Gabriel

    tools may no longer be feasible, since they are generally based on extensive off-line studies. A core component of an efficient on-line dynamic security assessment is a fast and reliable contingency screening. As part of this thesis a contingency screening method is developed and its performance......The thesis concerns the development of tools and methods for on-line dynamic security assessment (DSA). In a future power system with low-dependence or even independence of fossil fuels, generation will be based to a large extent on noncontrollable renewable energy sources (RES), such as wind...... and solar radiation. Moreover, ongoing research suggests that demand response will be introduced to maintain power balance between generation and consumption at all times. Due to these changes the operating point of the power system will be less predictable and today’s stability and security assessment...

  20. Stabilization of premaxilla repositioned during secondary bone grafting in complete bilateral cleft lip and palate patients.

    Science.gov (United States)

    Behnia, Hossein; Mesgarzadeh, Abolhasan; Tehranchi, Azita; Morad, Golnaz; Samieerad, Sahand; Younessian, Farnaz

    2014-07-01

    Secondary bone grafting simultaneous to premaxillary repositioning is a well-recognized surgical procedure for the management of bilateral cleft lip and palate patients. Proper stabilization of the repositioned premaxilla is considered as a key factor for the success of secondary bone grafting because the mobility of the premaxillary segment jeopardizes graft integration. This case series reports a reliable method of premaxillary stabilization that incorporated the intrasurgical application of resin bone cement to cover and reinforce the arch bars or orthodontic brackets applied on the maxillary teeth. Occlusal loads were reduced by application of posterior bite blocks on the mandibular teeth. The stabilization method was performed on 7 patients (5 women and 2 men) with a mean age of 12.4 years. During postsurgery follow-ups, the repositioned premaxillary segments did not show mobility in any of the patients. The palatal fistulae were completely closed. Panoramic radiographies taken 2 months after surgery demonstrated acceptable graft integration. The patients have now been followed up to 5 years. No evidence of relapse has been observed. This technique seemed to be undemanding, included minimal laboratory procedure, and maintained the labial mucosa overlying the repositioned segment intact.

  1. Repositioning Your EMBA Program and Reinventing Your Brand: A Case Study Analysis

    Science.gov (United States)

    Petit, Francis

    2009-01-01

    The purpose of this research is to illustrate how Fordham University, the Jesuit University of New York, repositioned its Executive MBA Program and reinvented its brand, over a ten year period. More specifically, this research will analyze the current state of the Executive MBA market and will discuss the best practices and frameworks implemented…

  2. Quick repositioning maneuver for horizontal semicircular canal benign paroxysmal positional vertigo

    Institute of Scientific and Technical Information of China (English)

    Jinrang Li; Pengfei Guo; Shiyu Tian; Keliang Li; Hao Zhang

    2015-01-01

    Objective:To investigate the efficacy of quick repositioning maneuver for horizontal semicircular canal benign paroxysmal positional vertigo (H-BPPV). Methods:Clinical data of 67 patients with H-BPPV who underwent quick repositioning maneuver in our hospital from July 2009 to November 2014 were retrospectively analyzed. The maneuver involved rotating the patient in the axial plane for 180? from the involved side towards contralateral side as quickly as possible. Results:Complete symptom resolution was achieved in 61 patients (91.0%) at one week and in 64 patients (95.5%) at 3 months post-treatment. During the repositioning maneuver process, there were no obvious untoward responses except transient nausea with or without vomiting in a few patients. Conclusion:The results indicate that the quick repositioning maneuver is an easy and effective alternative treatment in the management of H-BPPV. Copyright © 2015 The Authors. Production & hosting by Elsevier (Singapore) Pte Ltd On behalf of PLA General Hospital Department of Otolaryngology Head and Neck Surgery. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

  3. Repositioning of an Intraventricular Dislocated Aortic Valve during Transcatheter Aortic Valve Implantation

    NARCIS (Netherlands)

    Natour, Ehsan; Douglas, Yvonne L.; Jainandunsing, Jayant S.; Schurer, Remco A. J.; van der Werf, Hendrik W.; van den Heuvel, Ad F. M.

    2014-01-01

    The case is presented of a 75-year-old man referred for transcatheter aortic valve implantation. During the procedure the prosthetic aortic valve became dislocated into the left ventricle shortly after expansion. The subsequent steps taken to reposition the valve using only materials at hand are des

  4. Repositioning Guidance and Counselling and Curriculum Innovation in Higher Education in Nigeria

    Science.gov (United States)

    Onyilofor, Florence N. C.

    2013-01-01

    This study focuses on repositioning guidance and counseling and curriculum innovation in higher education in Nigeria. Descriptive survey research design was employed in the study. The study covered four Federal universities in the South-West Geopolitical zone of Nigeria, namely University of Ibadan in Oyo State; Obafemi Awolowo University, Ile-Ife…

  5. Helmet Versus Active Repositioning for Plagiocephaly: A Three-Dimensional Analysis

    DEFF Research Database (Denmark)

    Lipira, A.B.; Gordon, S.; Darvann, Tron Andre;

    2010-01-01

    to rigorously compare outcomes of these 2 treatment methods. PATIENTS AND METHODS: Whole-head 3D surface scans of 70 infants with DP were captured before and after treatment by using stereophotogrammetric imaging technology. Helmeted (n = 35) and nonhelmeted/actively repositioned (n = 35) infants were matched...

  6. Repositioning Technical and Vocational Education and Training (TVET) for Youths Employment and National Security in Nigeria

    Science.gov (United States)

    Ogbunaya, T. C.; Udoudo, Ekereobong S.

    2015-01-01

    The paper focused on repositioning Technical and Vocational Education and Training (TVET) for youth's employment and national security in Nigeria. It examined briefly the concepts of technical vocational education and training (TVET), youths, unemployment and national security as well as the effects of unemployment on national security in Nigeria.…

  7. Use of canalith repositioning manoeuvres and vestibular rehabilitation: a GP survey

    Science.gov (United States)

    van Vugt, Vincent A.; Diaz Nerio, Patria M.; van der Wouden, Johannes C.; van der Horst, Henriëtte E.; Maarsingh, Otto R.

    2017-01-01

    Objective To investigate the use of canalith repositioning manoeuvres and vestibular rehabilitation (VR) by GPs and to assess reasons for not using these techniques in patients with vertigo. Design Online survey. Setting GPs in the western and central part of the Netherlands. Subjects and method Of GPs, 1169 were approached to participate in the survey. A sample of 426 GPs filled out the questionnaire (36.4% response rate). The 22-item questionnaire contained both multiple choice and free-text questions on the Epley manoeuvre, the Brandt-Daroff exercises and VR. Results of the survey were descriptively analyzed. Main outcome measures The use of the Epley manoeuvre, the Brandt-Daroff exercises and VR by GPs; reasons that deter GPs from using these techniques. Results The repositioning manoeuvres (Epley manoeuvre and Brandt-Daroff exercises) were used by approximately half of all GPs (57.3 and 50.2%), while only a small group of GPs applied VR (6.8%). The most important reason for GPs not to use the Epley manoeuvre, Brandt-Daroff exercises and VR was that they did not know how to perform the technique (49.5, 89.6 and 92.4%). Conclusions Despite the proven effectiveness, repositioning manoeuvres and VR are remarkably underused by Dutch GPs. Not knowing how to perform the technique is the most important reason for GPs not to use these techniques. Efforts should be made to increase the knowledge and skills of GPs regarding canalith repositioning manoeuvres and VR. Key points Dizziness is a common symptom with limited therapeutic options. Canalith repositioning manoeuvres and vestibular rehabilitation represent the best treatment options currently available for vertigo. Canalith repositioning manoeuvres and vestibular rehabilitation are still widely underused by GPs. The most important reason for GPs not to use these techniques is that they do not know how to perform them. Efforts should be made to increase the knowledge and skills of GPs regarding canalith repositioning

  8. New Trends in on-line Marketing

    OpenAIRE

    Palkovič, Lukáš

    2011-01-01

    This bachelor thesis deals with new trend of internet marketing, it focuses especially on viral marketing. The theoretical part charasterizes the process of viral campaigns, furthermore deals with the components and aspects of on-line environment. Another separated chapter presents social networks, their place in viral marketing and at last but not least the viral video making process. The practical part contains different analyses of specific viral campaigns. The next and equally the last pa...

  9. Connecting to On-line Data

    Science.gov (United States)

    Eichhorn, G.; Astrophysics Datacenter Executive Committee (ADEC)

    2004-05-01

    The Astrophysics Datacenter Executive Committee (ADEC) is coordinating the development of a system to facilitate the linking to on-line data. This system has three components: 1. Unique dataset identifiers. 2. A verification system for identifiers. 3. Permanent links to on-line data sets. 1. The ADEC has agreed on a naming scheme for data sets that allows for the unique identification of any data set. The ADEC data centers will clearly mark their data with these identifiers to allow the generation of links to these data. 2. Each data center has a utility that can check whether a data set identifier is a valid identifier at that center. A central verifier allows third parties access to these individual verifiers through a single portal. 3. The central verifier also provides permanent links to data sets through a central link forwarding system. This makes it possible to move data sets between data centers while maintaining the permanent links. The ADEC plans to first use this system to implement the linking from the literature to on-line data in a collaboration with the AAS and the University of Chicago Press for the AAS journals.

  10. An On-line Assessment System for English-Chinese Translation

    Institute of Scientific and Technical Information of China (English)

    TIAN Yan; LU Ru-zhan; DUAN Jian-yong

    2007-01-01

    On-line assessment of English-Chinese translation is a challenging task as it involves natural language processing. YanFa, an on-line assessment system for English-Chinese translation, is a pilot research project into scoring student's translation on-line. Based on the theory of translation equivalence, an algorithm called "conceptual similarity matching" was developed. YanFa can assess students' translation on-line timely, generate test papers automatically, offer standard versions of translation, and the scores of each sentence to students. The evaluation proves that YanFa is practical compared with the scores given by experts.

  11. 基于DSP和小波变换的电压暂态扰动在线监测方法研究%Study of voltage transient disturbance on-line detection based on DSP and wavelet transform

    Institute of Scientific and Technical Information of China (English)

    王飞; 黄细霞; 张兵; 骆秀江

    2015-01-01

    A voltage disturbance detection device based on DSP2812 is designed in this paper. A method of transient voltage disturbance detection based on DSP and wavelet transform is studied. The system takes a Hall sensor and the parallel A/D con⁃verter chip as its acquisition circuit,and a kind of digital signal processing chip TMS320F2812 as its core information process⁃ing unit,by which the design of DSP and its peripheral circuit are achieved. The discrete wavelet transform(DWT)is adopted to detect transient voltage disturbance on line and realize wavelet algorithm in DSP. Software modules including the main pro⁃gram module,A/D module,interrupt module,communication module and so on were designed. Its simulation experiment was performed in Matlab to choose suitable wavelet functions and to locate disturbance position by utilizing DB4 wavelet in Matlab. The signal generator is used to produce the signal including transient voltage disturbance. The power acquisition and real⁃time analysis of transient voltage disturbance can be realized simultaneously by the strong operation ability of DSP and the effective DWT algorithm. The contrast test shows that the system has high precision,high data processing speed and perfect capability for real⁃time detection of transient voltage disturbance.%设计了一款基于DSP2812的电压暂态扰动在线检测装置,研究了基于DSP和小波变换的电压暂态扰动在线检测方法。该装置通过霍尔传感器和模数转换芯片采集电信号,以高性能数字信号处理芯片TMS320F2812为核心信息处理单元,完成了DSP及其外围电路设计。采用小波变换在线检测电压暂态扰动,并在DSP中实现了小波算法,软件还包括主程序模块、A/D采集模块、中断模块、上位机处理模块和通讯模块等设计。实验首先在Matlab中进行了仿真实验,选取合适的小波函数,利用Matlab中的DB4小波对扰动进行定位;然后再利用信号发生

  12. A Semi-Supervised Approach for Refining Transcriptional Signatures of Drug Response and Repositioning Predictions.

    Directory of Open Access Journals (Sweden)

    Francesco Iorio

    Full Text Available We present a novel strategy to identify drug-repositioning opportunities. The starting point of our method is the generation of a signature summarising the consensual transcriptional response of multiple human cell lines to a compound of interest (namely the seed compound. This signature can be derived from data in existing databases, such as the connectivity-map, and it is used at first instance to query a network interlinking all the connectivity-map compounds, based on the similarity of their transcriptional responses. This provides a drug neighbourhood, composed of compounds predicted to share some effects with the seed one. The original signature is then refined by systematically reducing its overlap with the transcriptional responses induced by drugs in this neighbourhood that are known to share a secondary effect with the seed compound. Finally, the drug network is queried again with the resulting refined signatures and the whole process is carried on for a number of iterations. Drugs in the final refined neighbourhood are then predicted to exert the principal mode of action of the seed compound. We illustrate our approach using paclitaxel (a microtubule stabilising agent as seed compound. Our method predicts that glipizide and splitomicin perturb microtubule function in human cells: a result that could not be obtained through standard signature matching methods. In agreement, we find that glipizide and splitomicin reduce interphase microtubule growth rates and transiently increase the percentage of mitotic cells-consistent with our prediction. Finally, we validated the refined signatures of paclitaxel response by mining a large drug screening dataset, showing that human cancer cell lines whose basal transcriptional profile is anti-correlated to them are significantly more sensitive to paclitaxel and docetaxel.

  13. NEGOTIATION OF IDENTITY: (RECONSTRUCTION AND (REPOSITIONING OF SELF THROUGH LANGUAGE LEARNING

    Directory of Open Access Journals (Sweden)

    Naho Isiki

    2013-07-01

    Full Text Available Abstract: Becoming competent in a language involves more than just academic success, but also multi-faceted aspects of self in a situated context. The core of the study is to explore a participant’s experience as a marginalized student in a Filipino American community and the trajectories of learning a foreign language over time and space. Narratives from the participant reflect his approach toward language learning (LL as well as his motivation behind language learning. This study highlights the impact of foreign language learning experience upon the participant’s conflict, negotiation, and transformation of identity. Following his positioning analysis, the paper closely looks at how evaluation by other Filipinos within the community contributes to the participant’s ongoing (reconstruction and negotiation of identity. How these evaluations encourage or impede his access to heritage language and culture is analyzed based on the participant’s use of reported speech. The paper explored whether or not LL can be a way of negotiating and gaining agency, as well as how LL helps a marginalized learner to choose where and how he wants to belong to. The paper also looks at how marginalization motivates language learning, through which the participant seeks to reposition himself. The study also examines how power relationship (marginalized student in a situated context plays a role in the process of negotiation of identity and meaning-making of self. Results from this study conclude that through experiences in foreign language learning as well as negotiating meanings for being a Japanese as a Foreign Language (JFL student, the participant gradually shifts to belong to a different community prior to his language learning experience in which he can practice agency and is no longer a marginalized member of his heritage community.

  14. On-line Measuring Method for Shell Chamber Volume

    Institute of Scientific and Technical Information of China (English)

    ZHANG Li-zhong; WANG De-min; JIANG Tao; CAO Guo-hua; WANG Qi

    2005-01-01

    Using the ideal gas state equation, an on-line measuring method for the shell chamber volume is studied in this paper. After analyzing how various measurement parameters affect the measurement accuracy, the system parameters are optimized in this method. Because the shape and volume of the tested items are similar, the method of using "tamping" to raise the accuracy and speed of the measurement is put forward. Based on the work above, a prototype of the testing instrument for shell chamber volume was developed, automatically testing and controlling. Compared with the method of "water weight", this method is more accurate, quicker and more automotive, so it is adaptable for the use of on-line detection.

  15. Fractal groups: Emergent dynamics in on-line learning communities

    Directory of Open Access Journals (Sweden)

    Junia de Carvalho Fidelis Braga

    Full Text Available Drawing on complexity theory, this work discusses the complex dynamics and emergent patterns of on-line learning communities based on a doctoral study in the area of Applied Linguistics. The analysis will center on the interlocutions of fifty students who interacted in small groups without the teacher's direct intervention, in an undergraduate course offered by the School of Languages and Literature at the Federal University of Minas Gerais. By analyzing the data, I demonstrate that out of the interactions among the peers of autonomous on-line learning communities arise opportunities for the construction of shared meaning, distributed leadership, as well as other dynamics. I also demonstrate the fractal nature of these communities. Moreover, I discuss how these findings shed light on the creation and development of course designs for large groups.

  16. Escapist Motives for Playing On-Line Games

    DEFF Research Database (Denmark)

    Sudzina, Frantisek; Razmerita, Liana

    , Harteveld and Mayer’s framework (2009) of escapist motives, which identifies four main motives for playing on-line games: mundane breaking, stress relieving, pleasure seeking, and imagination conjuring. In the paper, we report preliminary findings from an exploratory questionnaire survey. Besides importance...... of escapist motives for playing Facebook and other on-line games, we investigate how they are linked to demographic data such as: age, gender, place of origin, along with other social interactions patterns and social network usage behavior, current gaming status and an estimate of gaming time. According......Social games have become popular along with the tremendous growth of social networking sites, esp. Facebook. There is a gap in literature on what motivates people to play Facebook games. This paper studies social games usage behavior of students. We focus on escapist reasons, based on Warmelink...

  17. Dynamic liquid-liquid-solid microextraction based on molecularly imprinted polymer filaments on-line coupling to high performance liquid chromatography for direct analysis of estrogens in complex samples.

    Science.gov (United States)

    Zhong, Qisheng; Hu, Yufei; Hu, Yuling; Li, Gongke

    2012-06-08

    A novel sample preparation technique termed dynamic liquid-liquid-solid microextraction (DLLSME) was developed and on-line coupled to high performance liquid chromatography (HPLC) for direct extraction, desorption, and analysis of trace estrogens in complex samples. The DLLSME consists of the aqueous donor phase, the organic medium phase and the molecularly imprinted polymer filaments (MIPFs) as solid acceptor phase. The organic solvent with lesser density was directly added on top of the aqueous sample, and the dynamic extraction was performed by circulating the organic solvent through the MIPFs inserted into a PEEK tube which served as an extraction and desorption chamber. Afterwards, the extracted analytes on the MIPFs were on-line desorbed and then introduced into the HPLC for analysis. To evaluate the feasibility of the on-line system, a new DLLSME-HPLC method was developed for the analysis of five estrogens in aqueous samples by using 17β-estradiol MIPFs as the solid phase. Under the optimized conditions, the enrichment factors of 51-70, limits of detection of 0.08-0.25 μg/L and precision within 4.5-6.9% were achieved. Furthermore, the proposed method was applied to the analysis of real samples including urine, milk and skin toner, satisfactory recovery (81.9-99.8%) and reproducibility (4.1-7.9%) were obtained. Especially, 0.59 μg/L of 17β-estradiol was determined in female urine sample. The DLLSME offers an attractive alternative for direct analysis of trace analytes in aqueous samples and could potentially be extended to other adsorptive materials.

  18. On Innovation and Development of IOTs-based On-line Supply Chain Finance%基于物联网的在线供应链金融的创新与发展

    Institute of Scientific and Technical Information of China (English)

    李昀柏

    2015-01-01

    The definition of on-line supply chain finance was introduced and it was compared with traditional modes to reveal its innovation points. Besides,the technical support to on-line supply chain finance,the Internet of Things(IOTs), was described and current status and existing problems during the development of the financial mode in China were ana-lyzed. In the end,this paper points out that as every industry needs a few development stages to reach their sustainable de-velopment,it will be a long term development process for the perfection of on-line supply chain finance.%对在线供应链金融的概念进行了剖析,分析了其与传统供应链金融的不同,提出其创新点,并对在线供应链金融的技术支撑——物联网加以阐述。指出我国目前发展在线供应链金融的现状及存在的问题,提出任何一个行业的发展,都需要经历几个阶段才能够走向最终的可持续发展道路,而在线供应链金融也不例外,其必定是一个长期的发展过程。

  19. Study on Web-based Equipment On-line Fault Diagnosis System%一种基于网络的设备在线故障诊断系统研究

    Institute of Scientific and Technical Information of China (English)

    咸龙新; 田枫

    2012-01-01

    针对生产过程中设备参数时变、非稳态特点,提出了基于网络的故障诊断系统结构,用于设备的远程监测与故障诊断。设计了TE过程与模拟电路故障实验,结果表明应用该结构对设备进行监控可以提高设备故障诊断的准确率,降低系统维修成本,提高生产效率。针对快速性问题,采用提升小波与递推最小二乘支持向量机相混合的快速故障诊断方法;通过快速算法训练最小二乘支持向量机分类器,节省了存储空间和运算时间,增加了诊断模型的适应性。根据设计要求设计了工业故障诊断研究实验平台,并在此平台上对提出的方法进行了验证。该应用平台采用C/S,B/S的混合模式,集成Matlab,力控等专业软件系统,并采用OPC,ODBC,数据库技术实现了故障诊断系统的基本功能。%In allusion to the characteristic of time-varying, non-stationary, an architecture of on-line fault diagnosis system was presented for remote equipment monitoring and defalut diagnosing. This system is applied to the fault diagnosis of Tennessee Eastman (TE) model and analog circuit. The result indicates the application of the presented algorithms to monitor the equipment can lead to a considerable reduction in the number of false alarms and maintenance cost, and production yeild increse. A combined fault diagnosis method based on lifting wavelet and recursive least squares support vector machine of LW-RLSSVM is proposed to realize fast fault diagnosis for complex industrial processes. Data are denoised by lifting wavelet transform in real time, then least squares support vector machine classifier is trained by real-time algorithm. According to the request, an industry platform with the function of fault diagnosis is established. This platform adopts the modes of mixing of Client/Server(C/S) and Browser/Sever (B/S). This platform is established with integration of some special

  20. 基于电子商务的电力科技期刊网络出版平台研究及构建%Study and construction of on-line publishing platform for electric power journals based on c-commerce

    Institute of Scientific and Technical Information of China (English)

    何长华; 刘长青; 何鹏; 费兰花

    2011-01-01

    对《电力建设》《电网技术》等电力科技期刊电子数据进行整合,构建了基于电子商务的电力科技期刊网络出版平台。介绍该平台的技术实现,以及论文数据库、电子在线支付、在线阅读器等主要功能模块的建设,以期进行期刊社自建网站开展电子商务活动的实践及探索。%The e-data of Electric Power Construction and Electric Power System have been integrated and an on-line publishing platform for electric power journals has been established based on ecommerce. Technical methods for the on-line publishing platform and the construction of the main function modules such as paper databases, on-line payment and on-line reader are introduced in this paper for the purpose of carrying out e-commerce activities with the self-established website.

  1. Total on-line purchasing system (TOPS)

    Energy Technology Data Exchange (ETDEWEB)

    Collins, N.

    1995-11-01

    The Information Management Division (IMD) at LLNL is developing a new purchasing system for the Procurement Department. The first major development of this new system is called, {open_quotes}Total On-Line Purchasing System{close_quotes} (TOPS). TOPS will help speed up the requisitioning process by having requisitions electronically entered by requesters and electronically sent to buyers to be put on Purchase Orders. The new purchasing system will use Electronic Commerce (EC)/Electronic Data Interchange (EDI), to help increase transaction flows for shipping notices, RFQs, Quotes, Purchase Orders, and Invoices. ANSI X.12 is the EDI standard that this new EC will use.

  2. On-line programming technology of on-chip Flash in TMS320LF240x DSP based on CH376%基于 CH376实现 TMS320 LF240 x片内Flash在线编程

    Institute of Scientific and Technical Information of China (English)

    熊金

    2014-01-01

    This paper particular introduced the software and hardware design that apply with on-line programming technology.The flows of search files and read or write data through CH376, also the con-version method of bin files and on-line programming were provided.This technology applied to practical engineering and brought more convenience and reduced the product recall because of the system update and maintenance.%详细介绍利用CH376芯片实现在线编程的软硬件设计,给出通过CH376实现文件查找和文件数据块读取的详细流程,bin文件的转换方法以及在线编程的流程。该设计成功应用于系统开发中,给系统升级维护提供了诸多便利,减少因系统升级维护导致的产品召回。

  3. The new on-line Czech Food Composition Database.

    Science.gov (United States)

    Machackova, Marie; Holasova, Marie; Maskova, Eva

    2013-10-01

    The new on-line Czech Food Composition Database (FCDB) was launched on http://www.czfcdb.cz in December 2010 as a main freely available channel for dissemination of Czech food composition data. The application is based on a complied FCDB documented according to the EuroFIR standardised procedure for full value documentation and indexing of foods by the LanguaL™ Thesaurus. A content management system was implemented for administration of the website and performing data export (comma-separated values or EuroFIR XML transport package formats) by a compiler. Reference/s are provided for each published value with linking to available freely accessible on-line sources of data (e.g. full texts, EuroFIR Document Repository, on-line national FCDBs). LanguaL™ codes are displayed within each food record as searchable keywords of the database. A photo (or a photo gallery) is used as a visual descriptor of a food item. The application is searchable on foods, components, food groups, alphabet and a multi-field advanced search. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. DEVELOPMENT OF AN ON-LINE COAL WASHABILITY ANALYZER

    Energy Technology Data Exchange (ETDEWEB)

    J.D. Miller; C.L. Lin; G.H. Luttrell; G.T. Adel; Barbara Marin

    2001-06-26

    Washability analysis is the basis for nearly all coal preparation plant separations. Unfortunately, there are no on- line techniques for determining this most fundamental of all coal cleaning information. In light of recent successes at the University of Utah, it now appears possible to determine coal washability on-line through the use of x-ray computed tomography (CT) analysis. The successful development of such a device is critical to the establishment of process control and automated coal blending systems. In this regard, Virginia Tech, Terra Tek Inc., and U.S. coal producers have joined with the University of Utah and to undertake the development of an X-ray CT-based on- line coal washability analyzer with financial assistance from DOE. Each project participant brought special expertise to the project in order to create a new dimension in coal cleaning technology. The project involves development of appropriate software and extensive testing/evaluation of well-characterized coal samples from operating coal preparation plants. Data collected to date suggest that this new technology is capable of serving as a universal analyzer that can not only provide washability analysis, but also particle size distribution analysis, ash analysis, and perhaps pyritic sulfur analysis.

  5. DEVELOPMENT OF AN ON-LINE COAL WASHABILITY ANALYZER

    Energy Technology Data Exchange (ETDEWEB)

    J.D. Miller

    1999-09-30

    Washability analysis is the basis for nearly all coal preparation plant separations. Unfortunately, there are no on-line techniques for determining this most fundamental of all coal cleaning information. In light of recent successes at the University of Utah, it now appears possible to determine coal washability on-line through the use of x-ray computed tomography (CT) analysis. The successful development of such a device is critical to the establishment of process control and automated coal blending systems. In this regard, Virginia Tech, Terra Tek Inc., and several eastern coal companies have joined with the University of Utah and agreed to undertake the development of a x-ray CT-based on-line coal washability analyzer with financial assistance from DOE. The three-year project will cost $594,571, of which 33% ($194,575) will be cost-shared by the participants. The project involves development of appropriate software and extensive testing/evaluation of well-characterized coal samples from operating coal preparation plants. Each project participant brings special expertise to the project which is expected to create a new dimension in coal cleaning technology. Finally, it should be noted that the analyzer may prove to be a universal analyzer capable of providing not only washability analysis, but also particle size distribution analysis, ash analysis and perhaps pyritic sulfur analysis.

  6. A note on on-line Ramsey numbers for quadrilaterals

    Directory of Open Access Journals (Sweden)

    Joanna Cyman

    2014-01-01

    Full Text Available We consider on-line Ramsey numbers defined by a game played between two players, Builder and Painter. In each round Builder draws an the edge and Painter colors it either red or blue, as it appears. Builder's goal is to force Painter to create a monochromatic copy of a fixed graph \\(H\\ in as few rounds as possible. The minimum number of rounds (assuming both players play perfectly is the on-line Ramsey number \\(\\widetilde{r}(H\\ of the graph \\(H\\. An asymmetric version of the on-line Ramsey numbers \\(\\widetilde{r}(G,H\\ is defined accordingly. In 2005, Kurek and Ruciński computed \\(\\widetilde{r}(C_3\\. In this paper, we compute \\(\\widetilde{r}(C_4,C_k\\ for \\(3 \\le k \\le 7\\. Most of the results are based on computer algorithms but we obtain the exact value \\(\\widetilde{r}(C_4\\ and do so without the help of computer algorithms.

  7. Internet Teaching By Style: Profiling the On-line Professor

    Directory of Open Access Journals (Sweden)

    Sharon Strand

    2000-01-01

    Full Text Available The goal of this article is to offer the results of a pilot study which examined the personality type and teaching style preferences of faculty who elected to teach an on-line course. The article will present a description of personality assessments, including the Myers-Briggs Type Indicator (MBTI and Anthony Gregorc's Transaction Ability Inventory used to determine teaching tendencies and styles. In addition, a structured written questionnaire developed by the researchers was used to assess teacher satisfaction with worldwide web-based instruction. Utilizing the results of these psychological assessments, a preliminary analysis of the personal characteristics of college professors who chose to teach on line will be presented. This pilot study found that some preferred teaching styles may be more compatible with the dynamics of distance learning formats. By determining successful teaching styles for on-line courses, we can develop more effective faculty development programs to assist others in successfully transitioning into the cyber-teaching and learning environment.

  8. Efficient and Secure Comparison for On-Line Auctions

    DEFF Research Database (Denmark)

    Damgård, Ivan Bjerre; Krøigaard, Mikkel; Geisler, Martin Joakim

    2007-01-01

    We propose a protocol for secure comparison of integers based on homomorphic encryption. We also propose a homomorphic encryption scheme that can be used in our protocol and makes it more efficient than previous solutions. Our protocol is well-suited for application in on-line auctions, both...... with respect to functionality and performance. It minimizes the amount of information bidders need to send, and for comparison of 16 bit numbers with security based on 1024 bit RSA (executed by two parties), our implementation takes 0.28 seconds including all computation and communication. Using precomputation...

  9. Accuracy of combined maxillary and mandibular repositioning and of soft tissue prediction in relation to maxillary antero-superior repositioning combined with mandibular set back A computerized cephalometric evaluation of the immediate postsurgical outcome using the TIOPS planning system

    DEFF Research Database (Denmark)

    Donatsky, Ole; Bjørn-Jørgensen, Jens; Hermund, Niels Ulrich

    2009-01-01

    surgical planning system (TIOPS). MATERIAL AND METHODS: Out of 100 prospectively and consecutively treated patients, 52 patients manifested dentofacial deformities requiring bimaxillary orthognathic surgery with maxillary antero-superior repositioning combined with mandibular set back and so were included...

  10. Asphalt pavement surface 3D data acquisition system based on line-structure light%基于线结构光的沥青路面三维数据采集系统

    Institute of Scientific and Technical Information of China (English)

    孙朝云; 呼延菊; 李伟; 魏子尧; 刘祝

    2016-01-01

    To solve the problem of poor real-time,low accuracy of current asphalt pavement surface 3D data acquisition system,which can not provide 3D pavement data comprehensively,this paper studied an asphalt pavement 3D data acquisition system based on line-structure light.The system was a three-dimensional equipment with optical and electrical integration and automation,which was designed for domestic road three-dimensional information detection.It could realize data collection,analysis,processing,3D display for asphalt pavement surface topography.The system used infrared laser light source,planar array CCD camera and digital image detection technology.This system computed the 3D depth information based on laser triangulation algorithm,finished 3D reconstruction of road surface morphology by use of MATLAB software to obtain 3D display after reconstruction,and did quantitative analysis of detection results.Based on modular design,this system mainly consisted of power supply module,salve computer control module,counting trigger module,laser triangulation detection module,GPS module and data processing module.The 3D data of asphalt pavement were obtained through testing software's driving hardware modules.The results show that modular design improves anti-interference,making the system structure simple and clear,and relieve from the complex wires.It is convenient for debugging,maintenance,shorten development cycle,and the cost for development and maintenance is also reduced.The results also show that the system can not only meet the requirements of asphalt pavement 3D data acquisition and the requirements of real-time detection,but also provide vivid and visualized 3D visual topography.17 figs,21 refs.%针对目前沥青路面表面形貌三维数据采集实时性差、精确度低,难以准确全面地提供路面三维构造形态的问题,研究了基于线结构光的沥青路面表面形貌三维数据采集系统.该系统是针对中国道路三维信息检测要求

  11. NFFinder: an online bioinformatics tool for searching similar transcriptomics experiments in the context of drug repositioning.

    Science.gov (United States)

    Setoain, Javier; Franch, Mònica; Martínez, Marta; Tabas-Madrid, Daniel; Sorzano, Carlos O S; Bakker, Annette; Gonzalez-Couto, Eduardo; Elvira, Juan; Pascual-Montano, Alberto

    2015-07-01

    Drug repositioning, using known drugs for treating conditions different from those the drug was originally designed to treat, is an important drug discovery tool that allows for a faster and cheaper development process by using drugs that are already approved or in an advanced trial stage for another purpose. This is especially relevant for orphan diseases because they affect too few people to make drug research de novo economically viable. In this paper we present NFFinder, a bioinformatics tool for identifying potential useful drugs in the context of orphan diseases. NFFinder uses transcriptomic data to find relationships between drugs, diseases and a phenotype of interest, as well as identifying experts having published on that domain. The application shows in a dashboard a series of graphics and tables designed to help researchers formulate repositioning hypotheses and identify potential biological relationships between drugs and diseases. NFFinder is freely available at http://nffinder.cnb.csic.es.

  12. Can stimulating massage improve joint repositioning error in patients with knee osteoarthritis?

    DEFF Research Database (Denmark)

    Lund, Hans; Henriksen, Marius; Bartels, Else M

    2009-01-01

    PURPOSE: The purpose of this study was to investigate the effect of massage applied to the thigh muscles on joint repositioning error (JRE) in patients suffering from osteoarthritis (OA).We hypothesized that stimulating massage of the muscles around an osteoarthritic knee joint, could improve...... of rheumatology, were randomly allocated to either receive massage and a week later, act as controls or vice versa. The applied massage consisted of stimulating massage of the quadriceps femoris, sartorious, gracilus, and hamstrings muscles for 10 min on the affected leg. Participants had their JRE measured...... before and immediately after the 10 min massage and control sessions. Data were analyzed by using paired t-test. RESULTS: No significant change in JRE was observed (95% CI: -0.62 degrees to 0.85 degrees, p = 0.738). CONCLUSION: Massage has no effect on the immediate joint repositioning error in patients...

  13. Can stimulating massage improve joint repositioning error in patients with knee osteoarthritis?

    DEFF Research Database (Denmark)

    Lund, Hans; Henriksen, Marius; Bartels, Else M

    2009-01-01

    PURPOSE: The purpose of this study was to investigate the effect of massage applied to the thigh muscles on joint repositioning error (JRE) in patients suffering from osteoarthritis (OA).We hypothesized that stimulating massage of the muscles around an osteoarthritic knee joint, could improve...... of rheumatology, were randomly allocated to either receive massage and a week later, act as controls or vice versa. The applied massage consisted of stimulating massage of the quadriceps femoris, sartorious, gracilus, and hamstrings muscles for 10 min on the affected leg. Participants had their JRE measured...... before and immediately after the 10 min massage and control sessions. Data were analyzed by using paired t-test. RESULTS: No significant change in JRE was observed (95% CI: -0.62 degrees to 0.85 degrees, p = 0.738). CONCLUSION: Massage has no effect on the immediate joint repositioning error in patients...

  14. Repositioning of premaxilla in bilateral cleft lip and palate using a "J-hook headgear".

    Science.gov (United States)

    Kecik, Defne; Enacar, Ayhan

    2006-11-01

    The purpose of this clinical approach is to present the successful treatment of the severely protruded and extruded premaxilla with high-pull J-hook headgear. Two patients with bilateral cleft lip and palate deformity and a protruding and extruding premaxilla causing a deep bite were treated with high-pull J-hook headgear and fixed orthodontic appliances. The lateral cephalometric measurements before and after orthodontic treatment were evaluated with Ricketts analysis. The premaxillae of the two patients were repositioned, correcting the deep overbite and overjet and a well-functioning occlusion was attained. The repositioning of an inferiorly positioned and protruded premaxilla with J-hook headgear is an alternative treatment approach compared to other treatment modalities.

  15. Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

    OpenAIRE

    Eriksson, Anna; Österroos, Albin; Hassan, Sadia Bashir; Gullbo, Joachim; Rickardson, Linda; Jarvius, Malin; Nygren, Peter; Fryknäs, Mårten; Höglund, Martin; Larsson, Rolf

    2015-01-01

    To find drugs suitable for repositioning for use against leukemia, samples from patients with chronic lymphocytic, acute myeloid and lymphocytic leukemias as well as peripheral blood mononuclear cells (PBMC) were tested in response to 1266 compounds from the LOPAC1280 library (Sigma). Twenty-five compounds were defined as hits with activity in all leukemia subgroups (<50% cell survival compared with control) at 10 mu M drug concentration. Only one of these compounds, quinacrine, showed low...

  16. A Second WNT for Old Drugs: Drug Repositioning against WNT-Dependent Cancers

    OpenAIRE

    Kamal Ahmed; Shaw, Holly V.; Alexey Koval; Katanaev, Vladimir L.

    2016-01-01

    Aberrant WNT signaling underlies cancerous transformation and growth in many tissues, such as the colon, breast, liver, and others. Downregulation of the WNT pathway is a desired mode of development of targeted therapies against these cancers. Despite the urgent need, no WNT signaling-directed drugs currently exist, and only very few candidates have reached early phase clinical trials. Among different strategies to develop WNT-targeting anti-cancer therapies, repositioning of existing drugs p...

  17. Serial repositioning of a Guenther tulip retrievable inferior vena cava filter in a pediatric patient

    Energy Technology Data Exchange (ETDEWEB)

    Haider, Ehsan A.; Rosen, J. Choi; Torres, Carlos; Valenti, David A. [McGill University Health Center, Department of Radiology, Montreal, QC (Canada)

    2005-11-01

    We report an 11-year-old boy who required inferior vena cava (IVC) filtration for a prolonged period of time. A retrievable IVC filter was placed and repositioned three times, providing a total of 60 days of IVC filtration. The filter was removed when his risk of pulmonary embolus had decreased substantially. This is a relatively uncommon practice in the pediatric population. The technique is presented, and the available literature is reviewed. (orig.)

  18. Assessment of pose repeatability and specimen repositioning of a robotic joint testing platform.

    Science.gov (United States)

    El Daou, H; Lord, B; Amis, A; Rodriguez Y Baena, F

    2017-09-01

    This paper describes the quantitative assessment of a robotic testing platform, consisting of an industrial robot and a universal force-moment sensor, via the design of fixtures used to hold the tibia and femur of cadaveric knees. This platform was used to study the contributions of different soft tissues and the ability of implants and reconstruction surgeries to restore normal joint functions, in previously published literature. To compare different conditions of human joints, it is essential to reposition specimens with high precision after they have been removed for a surgical procedure. Methods and experiments carried out to determine the pose repeatability and measure errors in repositioning specimens are presented. This was achieved using an optical tracking system (fusion Track 500, Atracsys Switzerland) to measure the position and orientation of bespoke rigid body markers attached to the tibial and femoral pots after removing and reinstalling them inside the rigs. The pose repeatability was then evaluated by controlling the robotic platform to move a knee joint repeatedly to/from a given pose while tracking the position and orientation of a rigid body marker attached to the tibial fixture. The results showed that the proposed design ensured a high repeatability in repositioning the pots with standard deviations for the computed distance and angle between the pots at both ends of the joint equal to 0.1mm, 0.01mm, 0.13° and 0.03° for the tibial and femoral fixtures respectively. Therefore, it is possible to remove and re-setup a joint with high precision. The results also showed that the errors in repositioning the robotic platform (that is: specimen path repeatability) were 0.11mm and 0.12°, respectively. Copyright © 2017. Published by Elsevier Ltd.

  19. An Analysis of Lateral Crural Repositioning and Its Effect on Alar Rim Position.

    Science.gov (United States)

    Paquet, Christian A; Choroomi, Sim; Frankel, Andrew S

    2016-01-01

    Cephalically malpositioned lateral crura are a frequent cause of alar rim retraction during both primary and revision rhinoplasty. To demonstrate the efficacy of lateral crural repositioning as an isolated maneuver as and combined with adjunctive grafts for lowering the alar rim. From August through December 2014, we retrospectively reviewed the cases of 54 patients (102 hemi-noses) who had lateral crural repositioning performed by the same surgeon between 2007 and 2013. Only patients with standardized photographs taken preoperatively and at least 6 months postoperatively were included in the study. All primary and revision cases were completed via an open rhinoplasty approach and had lateral crural repositioning performed. Preoperative and postoperative photographs were compared using Adobe Photoshop CS via a modified Gunter technique to measure the degree of alar rim retraction on lateral views. The change in angle was then calculated, and statistical analysis conducted using a paired t test. A total of 54 patients (102 hemi-noses) met inclusion criteria; 42 (79%) were women, and the average patient age was 41.3 years. Forty-five (83%) of the cases were revision rhinoplasties, and the average time to obtaining postoperative photographs was 11.3 months. The mean (SD) anterior nostril apex angles preoperatively (31.3° [8.9°]) and postoperatively (24.5° [6.8°]) indicated a net decrease of 6.8° (P alar rim and/or composite grafts), we saw a similar result comparing preoperative (31.1° [8.2°]) and postoperative (24.5° [6.7°]) angles, with a net decrease of 6.6° degrees (P alar rim. Our data suggest that when combined with lateral crural repositioning, the addition of adjunctive grafts does not add significantly to the rim-lowering effect. 3.

  20. Management of intrusive luxation in the primary dentition by surgical repositioning: an alternative approach.

    Science.gov (United States)

    Shanmugam, H V; Arangannal, P; Vishnurekha, C; Nichani, M H; Vijayaprabha, K

    2011-06-01

    Intrusive luxation is the most common trauma during early infancy which results in the displacement of the tooth into its alveolus. Depending on the severity of the intrusion, the American Academy of Pediatric Dentistry recommends either extraction or spontaneous re-eruption for the primary tooth. This case report provides a brief insight into surgical repositioning as an alternative treatment option for the management of intruded primary tooth in a 4-year-old girl.

  1. Dual beam encoded extended fractional Fourier transform security hologram with in-built repositioning

    Indian Academy of Sciences (India)

    Amit K Sharma; D P Chhachhia; D Mohan; A K Aggarwal

    2008-01-01

    This paper describes a simple method for making dual beam encoded extended fractional Fourier transform (EFRT) security holograms. The hologram possesses different stages of encoding so that security features are concealed and remain invisible to the counterfeiter. These concealed and encoded anticounterfeit security features in the security hologram can only be read through a key hologram. Key hologram also facilitates in-built repositioning of security hologram. The method of fabrication, the principle of reconstruction and the experimental results are presented.

  2. Repositioning a displaced tracheostomy tube with an Aintree intubation catheter mounted on a fibre-optic bronchoscope.

    Science.gov (United States)

    Rajendram, R; McGuire, N

    2006-10-01

    Although tracheostomy tube displacement is uncommon, the management is often difficult and the associated mortality is high. It is important to ensure that the airway is secure and then either replace or reposition the tracheostomy tube. This case report describes the use of an Aintree intubation catheter (C-CAE-19.0-56-AIC, William Cook Europe, Denmark) mounted on an intubating fibre-optic bronchoscope (11302BD1, Karl Storz Endoskope, Germany) to reposition a partially displaced tracheostomy tube.

  3. An On-Line Monitoring System for Nitrate in Seawater Based on UV Spectrum%一种基于紫外光谱法的海水硝酸盐在线监测系统

    Institute of Scientific and Technical Information of China (English)

    李丹; 冯巍巍; 陈令新; 张骏

    2016-01-01

    Nitrate is one of the evaluation indicators of water quality ,which is particularly important for water quality monito-ring .A real-time on-line monitoring system of nitrate in water is introduced in this paper .And the ultraviolet absorption technol-ogy (190~370 nm) with partial least squares method is used to detect nitrate concentration .The automated online system based on ultraviolet absorption spectrum is capable of analyzing samples without any sample preservation and without contamination problems .This system is fast ,reliable ,and sensitive enough for continuous use on monitoring stations and nitrate concentration can also be determined directly via its ultraviolet absorption spectrum .This system uses flow sample cell with 1cm optical path length ,and a reference light is used to eliminate system error .The correlation coefficient for a linear function of the nitrate con-centrations is 0 .999 98 .So the results of the system model test are in good correlation with the laboratory ones .Data collected has been analyzed statistically to determine how system model behave throughout the test ,with special attention being paid to er-ror analysis .As the average relative error is 0.65% ,this system has greater stability and higher accuracy .The results of nitrate measurements by the field seawater tests in Yantai coast are obtained ,which nitrate concentrations are about 0.2 mg · L -1 in seawater ,and the recoveries of samples for standard recovery tests are in 95% ~110% ,it shows that this system is accurate ,re-liability and practicability and could be developed for detected nitrate concentration in natural water .%硝酸盐含量是水体质量指标之一 ,对于水质质量监测尤其重要.本文搭建了一种水体中硝酸盐在线原位监测系统 ,采用紫外吸收光谱法(190~240 nm )计算水样吸光度 ,并通过建立的偏最小二乘模型测定硝酸盐浓度 ,可用于海洋 ,河流 ,湖泊等多种水体.该自动在线监测系统

  4. Computational drugs repositioning identifies inhibitors of oncogenic PI3K/AKT/P70S6K-dependent pathways among FDA-approved compounds

    Science.gov (United States)

    Carrella, Diego; Manni, Isabella; Tumaini, Barbara; Dattilo, Rosanna; Papaccio, Federica; Mutarelli, Margherita; Sirci, Francesco; Amoreo, Carla A.; Mottolese, Marcella; Iezzi, Manuela; Ciolli, Laura; Aria, Valentina; Bosotti, Roberta; Isacchi, Antonella; Loreni, Fabrizio; Bardelli, Alberto; Avvedimento, Vittorio E.; di Bernardo, Diego; Cardone, Luca

    2016-01-01

    The discovery of inhibitors for oncogenic signalling pathways remains a key focus in modern oncology, based on personalized and targeted therapeutics. Computational drug repurposing via the analysis of FDA-approved drug network is becoming a very effective approach to identify therapeutic opportunities in cancer and other human diseases. Given that gene expression signatures can be associated with specific oncogenic mutations, we tested whether a “reverse” oncogene-specific signature might assist in the computational repositioning of inhibitors of oncogenic pathways. As a proof of principle, we focused on oncogenic PI3K-dependent signalling, a molecular pathway frequently driving cancer progression as well as raising resistance to anticancer-targeted therapies. We show that implementation of “reverse” oncogenic PI3K-dependent transcriptional signatures combined with interrogation of drug networks identified inhibitors of PI3K-dependent signalling among FDA-approved compounds. This led to repositioning of Niclosamide (Niclo) and Pyrvinium Pamoate (PP), two anthelmintic drugs, as inhibitors of oncogenic PI3K-dependent signalling. Niclo inhibited phosphorylation of P70S6K, while PP inhibited phosphorylation of AKT and P70S6K, which are downstream targets of PI3K. Anthelmintics inhibited oncogenic PI3K-dependent gene expression and showed a cytostatic effect in vitro and in mouse mammary gland. Lastly, PP inhibited the growth of breast cancer cells harbouring PI3K mutations. Our data indicate that drug repositioning by network analysis of oncogene-specific transcriptional signatures is an efficient strategy for identifying oncogenic pathway inhibitors among FDA-approved compounds. We propose that PP and Niclo should be further investigated as potential therapeutics for the treatment of tumors or diseases carrying the constitutive activation of the PI3K/P70S6K signalling axis. PMID:27542212

  5. Does prone repositioning before posterior fixation produce greater lordosis in lateral lumbar interbody fusion (LLIF)?

    Science.gov (United States)

    Yson, Sharon C; Sembrano, Jonathan N; Santos, Edward R G; Luna, Jeffrey T P; Polly, David W

    2014-10-01

    Retrospective comparative radiographic review. To determine if lateral to prone repositioning before posterior fixation confers additional operative level lordosis in lateral lumbar interbody fusion (LLIF) procedures. In a review of 56 consecutive patients who underwent LLIF, there was no statistically significant change in segmental lordosis from lateral to prone once a cage is in place. The greatest lordosis increase was observed after cage insertion. We reviewed 56 consecutive patients who underwent LLIF in the lateral position followed by posterior fixation in the prone position. Eighty-eight levels were fused. Disk space angle was measured on intraoperative C-arm images, and change in operative level segmental lordosis brought about by each of the following was determined: (1) cage insertion, (2) prone repositioning, and (3) posterior instrumentation. Paired t test was used to determine significance (α=0.05). Mean lordosis improvement brought about by cage insertion was 2.6 degrees (P=0.00005). There was a 0.1 degree mean lordosis change brought about by lateral to prone positioning (P=0.47). Mean lordosis improvement brought about by posterior fixation, including rod compression, was 1.0 degree (P=0.03). In LLIF procedures, the largest increase in operative level segmental lordosis is brought about by cage insertion. Further lordosis may be gained by placing posterior fixation, including compressive maneuvers. Prone repositioning after cage placement does not produce any incremental lordosis change. Therefore, posterior fixation may be performed in the lateral position without compromising operative level sagittal alignment.

  6. Temporomandibular joint disc repositioning using bone anchors: an immediate post surgical evaluation by Magnetic Resonance Imaging

    Directory of Open Access Journals (Sweden)

    Haddad Majd S

    2010-11-01

    Full Text Available Abstract Background Open joint procedures using bone anchors have shown clinical and radiograph good success, but post surgical disc position has not been documented with MRI imaging. We have designed a modified technique of using two bone anchors and 2 sutures to reposition the articular discs. This MRI study evaluates the post surgical success of this technique to reposition and stabilize the TMJ articular discs. Methods Consecutive 81 patients with unilateral TMJ internal derangement (ID (81 TMJs were treated between December 1, 2003, and December 1, 2006, at the Department of Oral and Maxillofacial Surgery, Ninth Peoples Hospital, Shanghai, Jiao Tong University School of Medicine. All patients were subjected to magnetic resonance imaging before and one to seven days post surgery to determine disc position using the modified bone anchor technique. Results Postoperative MRIs (one to seven days confirm that 77 of 81 joints were identified as excellent results and one joint was considered good for an overall effective rate of 96.3% (78 of 81 joints. Only 3.7% (3 of 81 of the joints were designated as poor results requiring a second open surgery. Conclusions This procedure has provided successful repositioning of the articular discs in unilateral TMJ ID at one to seven days post surgery.

  7. Short-term effects of backpack load placement on spine deformation and repositioning error in schoolchildren.

    Science.gov (United States)

    Chow, D H K; Ou, Z Y; Wang, X G; Lai, A

    2010-01-01

    Backpack weight of 10-15% has been recommended as an acceptable limit for schoolchildren. However, there is still no clear guideline regarding where the backpack centre of gravity (CG) should be positioned. The changes of spinal curvature and repositioning error when carrying a backpack loaded at 15% of body weight at different CG locations (anterior or posterior at T7, T12 or L3) in schoolchildren were analysed. Both spinal curvature and repositioning error were found to be affected by backpack anterior-posterior position and CG level. A relatively smaller change was observed during anterior carriage with the least change when the backpack CG was positioned at T12. The results also suggested that alternative carriage by changing the backpack position occasionally between anterior and posterior positions might help to relieve the effects of backpack on spine. However, future study is recommended to further substantiate the beneficial effects of alternative carriage on children. STATEMENT OF RELEVANCE: Anteriorly carried backpack with centre of gravity positioned at T12 was shown to induce relatively less effect on spinal deformation and repositioning error in schoolchildren. Changing backpack carriage position occasionally may help to relieve its effects on spinal deformation. The findings are important for ergonomic schoolbag design and determining a proper load carriage method.

  8. Improvement plans for the RHIC/AGS on-line model environments

    Energy Technology Data Exchange (ETDEWEB)

    Brown,K.A.; Ahrens, L.; Beebe-Wang, J.; Morris, J.; Nemesure, S.; Robert-Demolaize, G.; Satogata, T.; Schoefer, V.; Tepikian, S.

    2009-08-31

    The on-line models for Relativistic Ion Collider (RHIC) and the RHIC pre-injectors (the AGS and the AGS Booster) can be thought of as containing our best collective knowledge of these accelerators. As we improve these on-line models we are building the framework to have a sophisticated model-based controls system. Currently the RHIC on-line model is an integral part of the controls system, providing the interface for tune control, chromaticity control, and non-linear chromaticity control. What we discuss in this paper is our vision of the future of the on-line model environment for RHIC and the RHIC preinjectors. Although these on-line models are primarily used as Courant-Snyder parameter calculators using live machine settings, we envision expanding these environments to encompass many other problem domains.

  9. TELCAL: The On-line Calibration Software for ALMA

    Science.gov (United States)

    Broguière, D.; Lucas, R.; Pardo, J.; Roche, J.-C.

    2011-07-01

    The ALMA on-line calibration regroups all the operations needed to maintain the ALMA interferometer optimally tuned to successfully execute the planned observations. The results of the calibrations are used in quasi-real time by the ALMA Control System. Since the first ALMA antennas were put into operation in 2009, TELCAL has been used for all the basic calibration operations and is still being improved following the project advancement. We describe here the calibrations done by TELCAL, its relationships with the other ALMA software subsystems and, briefly, the architecture of the software based on CORBA.

  10. Molecularly imprinted polymers for on-line extraction techniques.

    Science.gov (United States)

    Moein, Mohammad M; Abdel-Rehim, Mohamed

    2015-01-01

    Recent years have seen an increasing interest in the use of molecularly imprinted polymers (MIPs) as a sorbent for different extraction methods and this is due to its high selectivity. The MIP is designed to show specificity for the analyte of interest. Moreover, MIPs show physical robustness, resistance to high temperatures and pressures, and stability in the presence of acids, bases and a wide range of organic solvents. In the present article, various novel sample preparation techniques which MIPs applied as sorbent and on-line connected with analytical instruments were highlighted and discussed. The future aspects of MIPs as well were described.

  11. Adaptive calibration method with on-line growing complexity

    Directory of Open Access Journals (Sweden)

    Šika Z.

    2011-12-01

    Full Text Available This paper describes a modified variant of a kinematical calibration algorithm. In the beginning, a brief review of the calibration algorithm and its simple modification are described. As the described calibration modification uses some ideas used by the Lolimot algorithm, the algorithm is described and explained. Main topic of this paper is a description of a synthesis of the Lolimot-based calibration that leads to an adaptive algorithm with an on-line growing complexity. The paper contains a comparison of simple examples results and a discussion. A note about future research topics is also included.

  12. On-line Monitoring and Active Control for Transformer Noise

    Science.gov (United States)

    Liang, Jiabi; Zhao, Tong; Tian, Chun; Wang, Xia; He, Zhenhua; Duan, Lunfeng

    This paper introduces the system for on-line monitoring and active noise control towards the transformer noise based on LabVIEW and the hardware equipment including the hardware and software. For the hardware part, it is mainly focused on the composition and the role of hardware devices, as well as the mounting location in the active noise control experiment. And the software part introduces the software flow chats, the measurement and analysis module for the sound pressure level including A, B, C weighting methods, the 1/n octave spectrum and the power spectrum, active noise control module and noise data access module.

  13. Dialectics of Educational Technology and Reposition of Islamic Religious Education: Teachers’ Role in Globalization Era

    Directory of Open Access Journals (Sweden)

    Agus Purwowidodo

    2016-12-01

    Full Text Available Learning technology as applied disciplines grows and evolves based to the needs of learning more effective, more efficient, more and more, more spacious, and more quickly in the globalization era. And also solves the problem, facilitating problem solving learning on design aspects, development, utilization, management, and assessment processes and sources in learning. Islamic religious education teachers challenge in the global era is the demands of the learning process that can improve informationliteracy that is well supported by data and facts to deliver to the students in the era of information society (information society and the scientific community (knowledge society. So it is needed an approach and innovative methods of learning strategies that address the challenges of learning needs in the era of globalization and information. Dialectics of technology on learning in a globalization era are characterized by the demands of the students to have critical thinking skills, problem solving, innovative and creative, mastering ICT, fluent communication, and multi languages. And also Islamic religious education teachers’ competence and interaction and learning technologies such as ICT products that push reposition the role of an advanced teacher trainers, counselors, managers, participants, leader and author of learning works as an abstraction and a high commitment as a base quality of professionalism. Teknologi pembelajaran sebagai  disiplin ilmu terapan tumbuh dan berkembang sesuai kebutuhan belajar  lebih efektif, lebih efisien, lebih banyak, lebih luas, lebih cepat di era global. serta memecahkan, memfasilitasi pemecahan masalah belajar pada aspek desain, pengembangan, pemanfaatan, pengelolaan, dan penilaian proses-proses dan sumber-sumber untu belajar. Tantangan guru PAI di era global adalah tuntutan terhadap proses pembelajaran yang mampu meningkatkan information literacy yang baik didukung oleh data dan fakta untuk menghantarkan

  14. Representação iterativa e folksonomia assistida para repositórios digitais | Iterative representation and folksonomy assisted for digital repositories

    Directory of Open Access Journals (Sweden)

    José Eduardo Santarém Segundo

    2011-03-01

    Full Text Available Resumo A recuperação da informação tem sido muito discutida dentro da Ciência da Informação ultimamente. A busca por informação de qualidade e compatível com a necessidade do usuário tornou-se objeto constante de pesquisa. A utilização da Internet como fonte de disseminação do conhecimento indicou novos modelos de armazenamento de informações, como os repositórios digitais, que têm sido utilizados em ambientes acadêmicos e de pesquisa como principal forma de autoarquivar e disseminar informação, porém com uma estrutura de informação que comporta melhor descrição dos recursos e consequentemente uma melhor recuperação da informação. Desta forma o objetivo deste trabalho é melhorar o processo de recuperação da informação, apresentando uma proposta de modelo estrutural no contexto da web semântica, abordando o uso de recursos da web 2.0 e web 3.0 em repositórios digitais, que permita recuperação semântica da informação, por meio da construção de uma camada de informação chamada Representação Iterativa. O presente estudo caracteriza-se como uma pesquisa descritiva e analítica, com base em análise documental, dividida em duas partes: a primeira, caracterizada pela observação direta não participativa de ferramentas que implementam repositórios digitais, assim como de repositórios digitais já instanciados, e a segunda, com característica exploratória, em que sugere um modelo inovador para repositórios, com a utilização de estruturas de representação do conhecimento e participação do usuário na construção de um vocabulário próprio de domínio. Através do modelo sugerido e proposto ─ Representação Iterativa ─ será possível adequar os repositórios digitais para que utilizem Folksonomia e também vocabulário controlado de domínio, de forma a gerar uma camada de informação iterativa, que possibilite retroalimentação da informação, além de recuperação semântica da

  15. 基于自适应UKF算法的MEMS陀螺空中在线标定技术%In-flight on-line calibration method for MEMS gyroscope based on adaptive unscented Kalman filter algorithm

    Institute of Scientific and Technical Information of China (English)

    秦伟; 苑伟政; 常洪龙; 薛亮

    2011-01-01

    The attitude sensors need to be calibrated on-line in order to guarantee the performance of system in the application of the micro-satellite.A real-time drift error estimation method of MEMS gyroscope is presented by using three-axis magnetometer measurements without any external attitude reference.The unscented Kalman filter (UKF) is applied as the optimal estimation algorithm, the gyroscope drift is used as the filter state vector, and the finite difference of magnetometers observation is established as the measurement vector.Since the measurements of the magnetometers are susceptible to interferences, and this would lead to inaccuracy of the filter model, the adaptive UKF is applied to decrease the drift estimation errors of the gyroscope by monitoring the measurements vectors and adjusting its covariance matrix on-line.The experiment results indicate that the accuracy of the calibrated MEMS gyroscopes has improved about 30%, and the filter parameters are adjusted automatically when the magnetometer measurements are deteriorated, which make the filter convergence.Furthermore, the accuracy of dynamic attitude computed by the calibrated MEMS gyroscope is smaller than 2°.%为保证微型卫星定位应用中系统精度与稳定性,需要对姿态传感器进行实时在线标定.在无外界姿态参考时,提出一种用三轴磁强计测量值来实时估计MEMs陀螺的零漂误差的方法,采用UKF滤波算法,将陀螺漂移作为滤波状态向量,通过建立三轴磁强计测量微分方程,作为系统量测方程实现陀螺漂移的最优估计.针对磁强计测量信息易受干扰导致滤波量测模型不准确的问题,将自适应因子引入到UKF中,通过在线监控和调整测量误差,减少陀螺标定的估计误差,增强系统性能.实验结果表明,经过标定,MEMS陀螺精度提高约30%,并且在磁强计有外界干扰时,陀螺的标定结果收敛.将标定后的MEMS陀螺进行姿态解算,其动态误差小于2°.

  16. Unintentional conversion of benign paroxysmal positional vertigo caused by repositioning procedures for canalithiasis: transitional BPPV.

    Science.gov (United States)

    Babic, Borivoj B; Jesic, Snezana D; Milovanovic, Jovica D; Arsovic, Nenad A

    2014-05-01

    BPPV when diagnosed before any repositioning procedure is called primary BPPV. Primary BPPV canalithiasis treatment with repositioning procedures sometimes results in unintentional conversion of BPPV form: transitional BPPV. Objectives were to find transitional BPPV forms, how they influence relative rate of canal involvement and how to be treated. This study is a retrospective case review performed at an ambulatory, tertiary referral center. Participants were 189 consecutive BPPV patients. Main outcome measures were detection of transitional BPPV, outcome of repositioning procedures for transitional canalithiasis BPPV and spontaneous recovery for transitional cupulolithiasis BPPV. Canal distribution of primary BPPV was: posterior canal (Pc): 85.7% (162/189), horizontal canal (Hc): 11.6% (22/189), anterior canal (Ac): 2.6% (5/189); taken together with transitional BPPV it was: Pc: 71.3% (164/230), Hc: 26.5% (61/230), Ac: 2.2% (5/230). Transitional BPPV forms were: Hc canalithiasis 58% (24/41), Hc cupulolithiasis 37% (15/41) and common crux reentry 5% (2/41). Treated with barbecue maneuver transitional Hc canalithiasis cases either resolved in 58% (14/24) or transitioned further to transitional Hc cupulolithiasis in 42% (10/24). In follow-up of transitional Hc cupulolithiasis we confirmed spontaneous recovery in 14/15 cases in less than 2 days. The most frequent transitional BPPV form was Hc canalithiasis so it raises importance of barbecue maneuver treatment. Second most frequent was transitional Hc cupulolithiasis which very quickly spontaneously recovers and does not require any intervention. The rarest found transitional BPPV form was common crux reentry which is treated by Canalith repositioning procedure. Transitional BPPV taken together with primary BPPV may decrease relative rate of Pc BPPV, considerably increase relative rate of Hc BPPV and negligibly influence relative rate of Ac BPPV. Transitional BPPV forms can be produced by repositioning maneuvers

  17. Target and peripheral dose during patient repositioning with the Gamma Knife automatic positioning system (APS) device.

    Science.gov (United States)

    Tran, Tuan-Anh; Stanley, Thomas R; Malhotra, Harish K; De Boer, Steven F; Prasad, Dheerendra; Podgorsak, Matthew B

    2010-01-28

    The GammaPlan treatment planning system does not account for the leakage and scatter dose during APS repositioning. In this study, the dose delivered to the target site and its periphery from the defocus stage and intershot couch transit (couch motion from the focus to defocus position and back) associated with APS repositioning are measured for the Gamma Knife model 4C. A stereotactic head-frame was attached to a Leksell 16 cm diameter spherical phantom with a calibrated ion chamber at its center. Using a fiducial box, CT images of the phantom were acquired and registered in the GammaPlan treatment planning system to determine the coordinates of the target (center of the phantom). An absorbed dose of 10 Gy to the 50% isodose line was prescribed to the target site for all measurements. Plans were generated for the 8, 14 and 18 mm collimator helmets to determine the relationship of measured dose to the number of repositions of the APS system and to the helmet size. The target coordinate was identical throughout entire study and there was no movement of the APS between various shots. This allowed for measurement of intershot transit dose at the target site and its periphery. The couch was paused in the defocus position, allowing defocus dose measurements at the intracranial target and periphery. Measured dose increases with frequency of repositioning and with helmet collimator size. During couch transit, the target receives more dose than peripheral regions; however, in the defocus position, the greatest dose is superior to the target site. The automatic positioning system for the Leksell Gamma Knife model 4C results in an additional dose of up to 3.87 +/- 0.07%, 4.97 +/- 0.04%, and 5.71 +/- 0.07% to the target site; its periphery receives additional dose that varies depending on its position relative to the target. There is also dose contribution to the patient in the defocus position, where the APS repositions the patient from one treatment coordinate to another

  18. On-Line Core Thermal-Hydraulic Model Improvement

    Energy Technology Data Exchange (ETDEWEB)

    In, Wang Kee; Chun, Tae Hyun; Oh, Dong Seok; Shin, Chang Hwan; Hwang, Dae Hyun; Seo, Kyung Won

    2007-02-15

    The objective of this project is to implement a fast-running 4-channel based code CETOP-D in an advanced reactor core protection calculator system(RCOPS). The part required for the on-line calculation of DNBR were extracted from the source of the CETOP-D code based on analysis of the CETOP-D code. The CETOP-D code was revised to maintain the input and output variables which are the same as in CPC DNBR module. Since the DNBR module performs a complex calculation, it is divided into sub-modules per major calculation step. The functional design requirements for the DNBR module is documented and the values of the database(DB) constants were decided. This project also developed a Fortran module(BEST) of the RCOPS Fortran Simulator and a computer code RCOPS-SDNBR to independently calculate DNBR. A test was also conducted to verify the functional design and DB of thermal-hydraulic model which is necessary to calculate the DNBR on-line in RCOPS. The DNBR margin is expected to increase by 2%-3% once the CETOP-D code is used to calculate the RCOPS DNBR. It should be noted that the final DNBR margin improvement could be determined in the future based on overall uncertainty analysis of the RCOPS.

  19. Influence of visualization on consumption during on-line shopping

    OpenAIRE

    Hictaler, Urška

    2013-01-01

    This diploma work studies the influence of visualization on consumption during on-line shopping. The first part of the thesis starts with key areas of visualization, consumption and on-line shopping. Visualization, areas of use, human perception and ways of product presentation in on-line shops are defined discussed first. Next, consumption, consumers and factors that influence their decisions and satisfaction are defined. The last topic in the first part of the thesis discusses on-line shopp...

  20. Based on the GPS Tailings Dam Displacement On-line Monitoring System Design%基于GPS的尾矿库坝体位移在线监测系统设计

    Institute of Scientific and Technical Information of China (English)

    欧阳伟; 李文建

    2012-01-01

    尾矿库作为一种高势能人造泥石流危险源,其坝体位移的在线监测对防止渍坝灾害的发生起到至关重要的作用,利用GPS技术精度高、抗干扰性强等特点并采用实时差分变形监测技术来测量坝体表面关键点的水平和竖直位移,利用RS232和GPRS无线传输技术来实现数据的采集和传输,并加装可靠的防雷和电源供电装置,可以大大提高矿山安全的生产系数.%Tailings pond is is a high dangerous potential energy artificial debris flow source, it plays a crucial role in preventing dam disaster by earring out dam displacement in on-line monitoring, as the GPS technology has high precision, strong anti-interference characteristics and so on, we can use real-time GPS differential deformation monitoring technology to measure the horizontal and vertical displacement of the key points of the dam surface, using RS232 and GPRS wireless transmission technology to realize data acquisition and transmission, and installing the reliable lightning protection and power supply unit can greatly improve the mine safety production coefficient.

  1. On-Line Monitoring System for Aquaculture Water Quality Based on CAN Bus%基于CAN总线的水产养殖水质在线监控系统设计与实现

    Institute of Scientific and Technical Information of China (English)

    王誉树; 蔡强; 郭冬莲; 诸寅; 章晓眉

    2014-01-01

    设计完成了一套水产养殖水质多参数在线监控系统,该系统采用CAN现场总线技术实现现场数据的传输,采用GSM无线通信技术进行远程数据采集和监控。本系统对温度、溶解氧、pH值、导电度等水质参数进行实时监测,并针对其中的溶解氧实现了自动控制。现场应用结果表明系统具有良好的实用性和稳定性,能较好的满足水产养殖水质监控的需求。%An on-line monitoring system for aquaculture water quality was designed. This system adopted CAN fieldbus technology to achieve on-site data transmission. GSM wireless communication technology was used for remote data acquisition and supervisory control. The water quality parameters including temperature, dissolved oxygen( DO) ,pH and electric conductivity( EC) were monitored in real time. The DO concentration was controlled automatically to avoid the fish death. The results demonstrated that this system is practical and stable, suggesting good potential for meeting the requirement of aquaculture water quality monitoring.

  2. Preparation and characterization of magnetic nanoparticles for the on-line determination of gold, palladium, and platinum in mine samples based on flow injection micro-column preconcentration coupled with graphite furnace atomic absorption spectrometry.

    Science.gov (United States)

    Ye, Juanjuan; Liu, Shuxia; Tian, Miaomiao; Li, Wanjun; Hu, Bin; Zhou, Weihong; Jia, Qiong

    2014-01-01

    A simple and highly selective procedure for on-line determination of trace levels of Au, Pd, and Pt in mine samples has been developed using flow injection-column adsorption preconcentration coupled with graphite furnace atomic absorption spectrophotometry (FI-column-GFAAS). The precious metals were adsorbed on the as-synthesized magnetic nanoparticles functionalized with 4'-aminobenzo-15-crown-5-ether packed into a micro-column and then eluted with 2% thiourea + 0.1 mol L(-1) HCl solution prior to the determination by GFAAS. The properties of the magnetic adsorbents were investigated by scanning electron microscope (SEM), X-ray diffraction (XRD), and vibrating sample magnetometer (VSM). Various experimental parameters affecting the preconcentration of Au, Pd, and Pt were investigated and optimized. Under the optimal experimental conditions, the detection limits of the developed technique were 0.16 ng mL(-1) for Au, 0.28 ng mL(-1) for Pd, and 1.01 ng mL(-1) for Pt, with enrichment factors of 24.3, 13.9, and 17.8, respectively. Precisions, evaluated as repeatability of results, were 1.1%, 3.9%, and 4.4% respectively for Au, Pd, and Pt. The developed method was validated by the analysis of Au, Pd, and Pt in certified reference materials and mine samples with satisfactory results. © 2013 Published by Elsevier B.V.

  3. On-Line Learning: One Way to Bring People Together

    Science.gov (United States)

    Goff-Kfouri, Carol Ann

    2006-01-01

    The purpose of this study was to demonstrate the benefits of on-line learning for adult learners and to further demystify three common misconceptions concerning on-line learning: students certainly do receive support from their on-line professors, the professor is pro-active rather than passive, and students may be more motivated to learn than in…

  4. On-line determination of anions in pulp mills by capillary electrophoresis (CE); Tehdasoloissa tapahtuva anionien kapillaarielektroforeettinen on-line maeaeritys ja sen hyoedyntaeminen prosessivalvonnassa - MPKY 02

    Energy Technology Data Exchange (ETDEWEB)

    Kokkonen, R.; Holmberg, M.; Vainikka, V. [Finnish Pulp and Paper Research Institute, Espoo (Finland)

    1998-12-31

    The aim of the study was to set-up a process control system for on-line measurement of certain anions. Typical anions which forms precipitates in pulp and paper mills are oxalate, carbonate and sulphate. Thus it is important to develop a continuous process analyzing system to control concentration levels of this anions. For the preliminary tests of continuous determinations of chloride and sulphate anions in tap water a simple on-line system was build in KCL (The Finnish Pulp and Paper Research Institute) and connected to a capillary electroforesis apparatus. In the preliminary tests a chromate buffer (ph = 7.6) was used. Separation of chloride and sulphate was excellent but the stability of buffer was not good enough and it was usable only for few hours. After experimental studies VTT developed a stable capillary electrophoresis method based on mixed amine buffer and this was selected for an on-line method for determination of anions in process waters of the pulp and paper industry. In the preliminary on-line test (r = 20) repeatabilities of migration times of sulphate and chloride with the chromate buffer were < 5 % (RSD) and peak heights < 15 % (RSD). With the mixed amine buffer repeatabilities were better. The preliminary tests showed that it is possible to connect a capillary electrophoresis system to on-line measurements. For the moment no commercial on-line CE apparatus is available. (orig.)

  5. 浅谈物联网水质在线监测系统在水产养殖中的应用%Talking about the Application of On-line Water Quality Monitoring System in Aquaculture Based on IOT(Internet of Tings)

    Institute of Scientific and Technical Information of China (English)

    任芳

    2014-01-01

    物联网技术的应用,是水产养殖技术的一场革命。研究了水产养殖中DO(溶解氧)、pH值、水温与水产生物之间的动态关系及在线监测方法,在探索水质在线传感器的选配与水质监测系统组建的同时,对物联网水质在线监测系统在太原市鱼种场的应用进行了实际测试。%The application of IOT technology is a revolution of aquaculture technology. This paper studies the dynamic relations among the DO, pH value, water temperature and aquatic organisms and the methods for on-line monitoring, and at the same time of probing into the choice of water quality on-line sensors and the establishment of water quality monitoring system, makes the practical tests on IOT based on-line water quality monitoring system applied in Taiyuan Fish Nursery.

  6. Research of on-line detection system for power capacitor

    Science.gov (United States)

    Yao, Junda; Qian, Zheng; Yu, Hao; Xia, Jiuyun

    2016-01-01

    The hidden danger exists in the power capacitor of power system due to long-time operation under the environment of high voltage. Thus, it is possible to induce serious fault, and the on-line detection system is urgently required. In this paper, two methods of the on-line detection system are compared in order to realize the better real-time condition detection. The first method is based on the STM microprocessor with an internal 12 bit A/D converter, which converts analog signals which is arrived from the sample circuit into digital signals, and then the FFT algorithm is used to accomplish the measurement of the voltage and current values of the capacitor. The second method is based on the special electric energy metering IC, which can obtain RMS (Root Mean Square) of voltage and current by processing the sampled data of the voltage and current, and store RMS of voltage and current in its certain registers. The operating condition of the capacitor can be obtained after getting the values of voltage and current. By comparing the measuring results of two methods, the second method could achieve a higher measurement accuracy and more simple construction.

  7. Polar On-Line Acquisition Relay and Transmission System (POLARATS)

    Energy Technology Data Exchange (ETDEWEB)

    Yuracko, K.

    2004-07-15

    POLARATS (Polar On-Line Acquisition Relay And Transmission System) is being developed by YAHSGS LLC (YAHSGS) and Oak Ridge National Laboratory (ORNL) to provide remote, unattended monitoring of environmental parameters under harsh environmental conditions. In particular, instrumental design and engineering is oriented towards protection of human health in the Arctic, and with the additional goal of advancing Arctic education and research. POLARATS will obtain and transmit environmental data from hardened monitoring devices deployed in locations important to understanding atmospheric and aquatic pollutant migration as it is biomagnified in Arctic food chains. An Internet- and personal computer (PC)-based educational module will provide real time sensor data, on-line educational content, and will be integrated with workbooks and textbooks for use in middle and high school science programs. The educational elements of POLARATS include an Internet-based educational module that will instruct students in the use of the data and how those data fit into changing Arctic environments and food chains. POLARATS will: (1) Enable students, members of the community, and scientific researchers to monitor local environmental conditions in real time over the Internet; and (2) Provide additional educational benefits through integration with middle- and high-school science curricula. Information will be relayed from POLARATS devices to classrooms and libraries along with custom-designed POLARATS teaching materials that will be integrated into existing curricula to enhance the educational benefits realized from the information obtained.

  8. On-line estimation of concentration parameters in fermentation processes

    Institute of Scientific and Technical Information of China (English)

    XIONG Zhi-hua; HUANG Guo-hong; SHAO Hui-he

    2005-01-01

    It has long been thought that bioprocess, with their inherent measurement difficulties and complex dynamics, posed almost insurmountable problems to engineers. A novel software sensor is proposed to make more effective use of those measurements that are already available, which enable improvement in fermentation process control. The proposed method is based on mixtures of Gaussian processes (GP) with expectation maximization (EM) algorithm employed for parameter estimation of mixture of models. The mixture model can alleviate computational complexity of GP and also accord with changes of operating condition in fermentation processes, i.e., it would certainly be able to examine what types of process-knowledge would be most relevant for local models' specific operating points of the process and then combine them into a global one. Demonstrated by on-line estimate of yeast concentration in fermentation industry as an example, it is shown that soft sensor based state estimation is a powerful technique for both enhancing automatic control performance of biological systems and implementing on-line monitoring and optimization.

  9. On-line learning algorithms for locally recurrent neural networks.

    Science.gov (United States)

    Campolucci, P; Uncini, A; Piazza, F; Rao, B D

    1999-01-01

    This paper focuses on on-line learning procedures for locally recurrent neural networks with emphasis on multilayer perceptron (MLP) with infinite impulse response (IIR) synapses and its variations which include generalized output and activation feedback multilayer networks (MLN's). We propose a new gradient-based procedure called recursive backpropagation (RBP) whose on-line version, causal recursive backpropagation (CRBP), presents some advantages with respect to the other on-line training methods. The new CRBP algorithm includes as particular cases backpropagation (BP), temporal backpropagation (TBP), backpropagation for sequences (BPS), Back-Tsoi algorithm among others, thereby providing a unifying view on gradient calculation techniques for recurrent networks with local feedback. The only learning method that has been proposed for locally recurrent networks with no architectural restriction is the one by Back and Tsoi. The proposed algorithm has better stability and higher speed of convergence with respect to the Back-Tsoi algorithm, which is supported by the theoretical development and confirmed by simulations. The computational complexity of the CRBP is comparable with that of the Back-Tsoi algorithm, e.g., less that a factor of 1.5 for usual architectures and parameter settings. The superior performance of the new algorithm, however, easily justifies this small increase in computational burden. In addition, the general paradigms of truncated BPTT and RTRL are applied to networks with local feedback and compared with the new CRBP method. The simulations show that CRBP exhibits similar performances and the detailed analysis of complexity reveals that CRBP is much simpler and easier to implement, e.g., CRBP is local in space and in time while RTRL is not local in space.

  10. On-line blind separation of non-stationary signals

    Directory of Open Access Journals (Sweden)

    Todorović-Zarkula Slavica

    2005-01-01

    Full Text Available This paper addresses the problem of blind separation of non-stationary signals. We introduce an on-line separating algorithm for estimation of independent source signals using the assumption of non-stationary of sources. As a separating model, we apply a self-organizing neural network with lateral connections, and define a contrast function based on correlation of the network outputs. A separating algorithm for adaptation of the network weights is derived using the state-space model of the network dynamics, and the extended Kalman filter. Simulation results obtained in blind separation of artificial and real-world signals from their artificial mixtures have shown that separating algorithm based on the extended Kalman filter outperforms stochastic gradient based algorithm both in convergence speed and estimation accuracy.

  11. 基于 NPTB 模型的影视网站影片推广组合预测%Adaptive Combined Forecasting for Promotion of Television Website On-line Video Based on NPTB Model

    Institute of Scientific and Technical Information of China (English)

    杨帅; 马少辉

    2014-01-01

    Under the premise of combination film and television audiences basic information , targeted at the film website new type of on-line charges videos , this paper proposes integration into the combination forecasting model on the basis of NPTB model .The model is used to predict the probability of a television audience watching which videos next , and to choose the highest probability of this type of movie viewers for movie promotion .So the purpose of film and television website ’ s earning is achieved .The exam-ple shows that this study is superior to the other prediction audience watch videos probability model .%在结合影视观众基本信息的前提下,针对影视网站新上线收费影片的类型,本文提出在NPTB ( Next-Product-to-Buy)模型的基础上融入组合预测模型,用来预测影视观众下一部可能接受观看的影片概率,在此基础上选择观看此类型影片概率最高的观众进行影片推广,以期达到影视网站盈利的目的。实验表明,本研究所用模型明显优于其它预测观众观看影片概率的模型。

  12. Trusted Allies with New Benefits: Repositioning Existing Drugs

    KAUST Repository

    Gao, Xin

    2016-01-25

    The classical assumption that one drug cures a single disease by binding to a single drug-target has been shown to be inaccurate. Recent studies estimate that each drug on average binds to at least six known and several unknown targets. Identifying the “off-targets” can help understand the side effects and toxicity of the drug. Moreover, off-targets for a given drug may inspire “drug repositioning”, where a drug already approved for one condition is redirected to treat another condition, thereby overcoming delays and costs associated with clinical trials and drug approval. In this talk, I will introduce our work along this direction. We have developed a structural alignment method that can precisely identify structural similarities between arbitrary types of interaction interfaces, such as the drug-target interaction. We have further developed a novel computational framework, iDTP that constructs the structural signatures of approved and experimental drugs, based on which we predict new targets for these drugs. Our method combines information from several sources including sequence independent structural alignment, sequence similarity, drug-target tissue expression data, and text mining. In a cross-validation study, we used iDTP to predict the known targets of 11 drugs, with 63% sensitivity and 81% specificity. We then predicted novel targets for these drugs—two that are of high pharmacological interest, the peroxisome proliferator-activated receptor gamma and the oncogene B-cell lymphoma 2, were successfully validated through in vitro binding experiments.

  13. Efficiency in Carrying Cargo to Earth Orbits: Spaceports Repositioning

    Directory of Open Access Journals (Sweden)

    Jakub Hospodka

    2016-10-01

    Full Text Available Space flights are in these days not any more question of technology, but more question of costs. One way how to decrease cost of launch is change of home spaceport. Change of home spaceport for different rockets is a way to achieve more efficient launches to space. The reason is different acceleration achieved from Earth rotation. We added several mathematical calculations of missions to Low Earth Orbit and Geostationary Earth Orbit to show bonuses from Earth rotation and effect of atmospheric drag on specific rockets used these days. We discussed only already used space vessels. Namely Arianne 5, Delta 4 heavy, Proton-M, Zenit and Falcon9. For reaching GEO we discuss possibility of using Hohmman transfer, because none of aforementioned vessels is available for direct GEO entry. As possible place for launch we discussed spaceports Baikonur, Kennedy Space center, Guyana Space center and Sea Launch platform. We present results in form of additional acceleration for each spaceport, and we also project this additional acceleration in means payload increase. In conclusion we find important differences between vessel effectivity based on spaceport used for launch. Change of launch location may bring significant cost decrease for operators.

  14. Development of an on-line state estimator for fed-batch filamentous fungal fermentations

    DEFF Research Database (Denmark)

    Mears, Lisa; Stocks, Stuart M.; Albæk, Mads O.

    Bioprocesses can be challenging to model due to complex and non-linear process dynamics [1]. In addition there is a lack of robust, on-line sensors for key parameters of interest in the field, such as substrate, product and biomass concentration [2]. These factors lead to limitations in the ability...... to monitor and control bioprocess systems. There is therefore an interest in state estimation, in order to model these key process states based on available on-line measurements [1]. This work discusses the application of a first principle model to pilot scale filamentous fungal fermentation systems operated...... pressure [4], [5]. This stoichiometric-based coupled process model is successfully applied on-line as a state estimator in order to predict the biomass and product concentration, from robust, available on-line measurements. Such state estimators will be valuable as part of control strategy development...

  15. Cable Fault Traveling Wave on Line Monitoring System Based on LabVIEW%基于LabVIEW的电缆故障行波在线监测系统

    Institute of Scientific and Technical Information of China (English)

    段金英

    2011-01-01

    The buried cables effected by complex, uneven electric field and thermal field, the surrounding environment and many other factors,has high rate of accidents. This paper presented a better real-time monitoring system,with the use of the development platform of National Instruments Corporation Lab VIEW virtual instrument and data acquisition cards, collects the continuous voltage,current of cable line and other parameters,to monitor the operation of transmission lines,The monitoring system realizes the fault current on-line monitoring through the device at the scene access to the Hall sensor cable voltage and current signals from the data acquisition card on the fault wave pop electric high-speed sampling and storage control, with the use of graphical programming language designed to monitor PC interface. Experimental results show that the system can accurately record fault current waveforms, amplitude, provide important data analysis of fault type and location.%针对埋地电缆敷设复杂,发生事故率高的情况,提出了使用LabVIEW和数据采集卡,不间断采集电缆线路上的电压、电流等参数,监视输电线路运行状况,并通过TCP节点,构建了一个实时性较好的监测系统.该监控系统通过装在现场的霍尔传感器获取电缆的电压电流信号,由数据采集卡对故障电流行波进行高速采样和存储控制,利用具有图形化的编程语言设计上位机监控界面,实现了故障电流的在线监测.试验结果表明:该系统能够准确地记录故障电流波形、幅值,为故障类型分析和定位提供了重要数据.

  16. Enantioselective analysis of pheniramine in urine by charged CD-mediated CZE provided with a fiber-based DAD and an on-line sample pretreatment by capillary ITP.

    Science.gov (United States)

    Marák, Jozef; Mikus, Peter; Maráková, Katarína; Kaniansky, Dusan; Valásková, Iva; Havránek, Emil

    2007-08-01

    Application potentialities of CZE on-line coupled with capillary ITP and DAD to the identification and determination of trace concentration levels (microg/L) of pheniramine (PHM) enantiomers and their metabolites present in complex ionic matrices of biological origin (urine) are shown. An enhanced (enantio)selectivity of the CZE separation system obtained by the addition of carboxyethyl-beta-CD (CE-beta-CD) to the carrier electrolyte provided CZE conditions for a reliable identification of similar/identical DAD spectra of structurally related compounds (PHM enantiomers and their metabolites) in clinical urine samples differing in qualitative and quantitative composition of sample matrix constituents. A high sample loadability (a 30 microL sample injection volume), partial sample clean-up (removing macroconstituents from the sample), and preconcentration of the analytes in ITP stage resulted in the decrease of concentration LOD for PHM enantiomers in urine to 5.2 and 6.8 microg/L (2.2 x 10(-8) and 2.8 x 10(-8) mol/L), without using any sample pretreatment technique. The background correction and smoothing procedure applied to the raw DAD spectra provided analytically relevant DAD spectra of PHM enantiomers and their metabolites also when they were present in urine sample (30 microL injection volumes of ten-times diluted urine sample) at a 9 x 10(-) (8) mol/L concentration. DAD spectra of PHM enantiomers present in urine samples matched their reference spectra with reasonable certainties. DAD spectra of PHM metabolites were compared with the reference spectra of PHM enantiomers and a good match was found which indicates the similarities in the structures of enantiomers and their metabolites detected in the urine samples. This fact allows performing the quantitative analyses of PHM metabolites in the urine samples by applying the calibration parameters of PHM enantiomers also for PHM metabolites and the results show the possibilities of using the ITP

  17. On-line structure-lossless digital mammogram image compression

    Science.gov (United States)

    Wang, Jun; Huang, H. K.

    1996-04-01

    This paper proposes a novel on-line structure lossless compression method for digital mammograms during the film digitization process. The structure-lossless compression segments the breast and the background, compresses the former with a predictive lossless coding method and discards the latter. This compression scheme is carried out during the film digitization process and no additional time is required for the compression. Digital mammograms are compressed on-the-fly while they are created. During digitization, lines of scanned data are first acquired into a small temporary buffer in the scanner, then they are transferred to a large image buffer in an acquisition computer which is connected to the scanner. The compression process, running concurrently with the digitization process in the acquisition computer, constantly checks the image buffer and compresses any newly arrived data. Since compression is faster than digitization, data compression is completed as soon as digitization is finished. On-line compression during digitization does not increase overall digitizing time. Additionally, it reduces the mammogram image size by a factor of 3 to 9 with no loss of information. This algorithm has been implemented in a film digitizer. Statistics were obtained based on digitizing 46 mammograms at four sampling distances from 50 to 200 microns.

  18. The Leuven isotope separator on-line laser ion source

    CERN Document Server

    Kudryavtsev, Y; Franchoo, S; Huyse, M; Gentens, J; Kruglov, K; Müller, W F; Prasad, N V S; Raabe, R; Reusen, I; Van den Bergh, P; Van Duppen, P; Van Roosbroeck, J; Vermeeren, L; Weissman, L

    2002-01-01

    An element-selective laser ion source has been used to produce beams of exotic radioactive nuclei and to study their decay properties. The operational principle of the ion source is based on selective resonant laser ionization of nuclear reaction products thermalized and neutralized in a noble gas at high pressure. The ion source has been installed at the Leuven Isotope Separator On-Line (LISOL), which is coupled on-line to the cyclotron accelerator at Louvain-la-Neuve. sup 5 sup 4 sup , sup 5 sup 5 Ni and sup 5 sup 4 sup , sup 5 sup 5 Co isotopes were produced in light-ion-induced fusion reactions. Exotic nickel, cobalt and copper nuclei were produced in proton-induced fission of sup 2 sup 3 sup 8 U. The b decay of the sup 6 sup 8 sup - sup 7 sup 4 Ni, sup 6 sup 7 sup - sup 7 sup 0 Co, sup 7 sup 0 sup - sup 7 sup 5 Cu and sup 1 sup 1 sup 0 sup - sup 1 sup 1 sup 4 Rh isotopes has been studied by means of beta-gamma and gamma-gamma spectroscopy. Recently, the laser ion source has been used to produce neutron-d...

  19. On-Line Adaptive Radiation Therapy: Feasibility and Clinical Study

    Directory of Open Access Journals (Sweden)

    Taoran Li

    2010-01-01

    Full Text Available The purpose of this paper is to evaluate the feasibility and clinical dosimetric benefit of an on-line, that is, with the patient in the treatment position, Adaptive Radiation Therapy (ART system for prostate cancer treatment based on daily cone-beam CT imaging and fast volumetric reoptimization of treatment plans. A fast intensity-modulated radiotherapy (IMRT plan reoptimization algorithm is implemented and evaluated with clinical cases. The quality of these adapted plans is compared to the corresponding new plans generated by an experienced planner using a commercial treatment planning system and also evaluated by an in-house developed tool estimating achievable dose-volume histograms (DVHs based on a database of existing treatment plans. In addition, a clinical implementation scheme for ART is designed and evaluated using clinical cases for its dosimetric qualities and efficiency.

  20. Solving a static repositioning problem in bike-sharing systems using iterated tabu search

    DEFF Research Database (Denmark)

    Ho, Sin C.; Szeto, W. Y.

    2014-01-01

    . The objective is to minimize the total penalties incurred at all the stations. We present an iterated tabu search heuristic to solve the described problem. Experimental results show that this simple heuristic can generate high quality solutions using small computing times.......In this paper, we study the static bike repositioning problem where the problem consists of selecting a subset of stations to visit, sequencing them, and determining the pick-up/drop-off quantities (associated with each of the visited stations) under the various operational constraints...

  1. Surgical repositioning of intruded immature permanent incisor: An updated treatment concept

    Directory of Open Access Journals (Sweden)

    Garg S

    2008-10-01

    Full Text Available Intrusion of immature permanent anterior teeth presents a great dilemma due to variety of treatment options. The ideal treatment option is the one with least probability of developing complications like external root resorption, obliteration of pulp canal, marginal bone loss etc. This paper presents a case report with treatment strategy of repositioning, splinting, successfully attempted apexification and obturation of a completely intruded immature permanent central incisor. Excellent healing with no post-operative complications even after 10 months of follow up.

  2. The CTSA Pharmaceutical Assets Portal – a public–private partnership model for drug repositioning

    Science.gov (United States)

    Marusina, Kate; Welsch, Dean J.; Rose, Lynn; Brock, Doug; Bahr, Nathan

    2011-01-01

    The Pharmaceutical Assets Portal aims to facilitate industry-academic collaborations for discovery of new indications for compounds no longer being developed by pharmaceutical companies, through eliminating barriers to access such compounds. The Portal’s enabling infrastructure includes a national investigator database; a Foci-of-Expertise browser; a material transfer agreement template; and a funding partner. Whereas the goal of creating a shared compound repository remains to be achieved, the Portal has established a mechanism to facilitate future drug repositioning opportunities. PMID:22768020

  3. Comparison of online IGRT techniques for prostate IMRT treatment: Adaptive vs repositioning correction

    Energy Technology Data Exchange (ETDEWEB)

    Thongphiew, Danthai; Wu, Q. Jackie; Lee, W. Robert; Chankong, Vira; Yoo, Sua; McMahon, Ryan; Yin Fangfang [Department of Radiation Oncology, Duke University Medical Center, P.O. Box 3295, Durham, North Carolina 27710 (United States); Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, Ohio 44106 (United States); Department of Radiation Oncology, Duke University Medical Center, P.O. Box 3295, Durham, North Carolina 27710 (United States)

    2009-05-15

    , and 15 fractions out of 30 total fractions, while it also had the best D90, D50, and D30 values for the rectum for 25, 16, and 19 fractions, respectively. For cases where the adapt plans did not score the best for OAR sparing, the gains of the OAR sparing in the repositioning-based plans were accompanied by an underdosage in the target volume. To further evaluate the fast online replanning technique, a gold-standard plan (''new'' plan) was generated for each CBCT anatomy on the Eclipse treatment planning system. The OAR sparing from the online replanning technique was compared to the new plan. The differences in D90, D50, and D30 of the OARs between the adapt and the new plans were less than 5% in 3 patients and were between 5% and 10% for the remaining three. In summary, all IGRT techniques could be sufficient to correct simple geometrical variations. However, when a high degree of deformation or differential organ position displacement occurs, the online reoptimization technique is feasible with less than 2 min optimization time and provides improvements in both CTV coverage and OAR sparing over the position correction techniques. For these cases, the reoptimization technique can be a highly valuable online IGRT tool to correct daily treatment uncertainties, especially when hypofractionation scheme is applied and daily correction, rather than averaging over many fractions, is required to match the original plan.

  4. Repositioning realism

    CSIR Research Space (South Africa)

    Ruttkamp-Bloem, E

    2015-03-01

    Full Text Available "Naturalised realism" is presented as a version of realism which is more compatible with the history of science than convergent or explanationist forms of realism. The account is unpacked according to four theses : 1) Whether realism is warranted...

  5. Persistent Direction-Fixed Nystagmus Following Canalith Repositioning Maneuver for Horizontal Canal BPPV: A Case of Canalith Jam.

    Science.gov (United States)

    Chang, Young-Soo; Choi, Jeesun; Chung, Won-Ho

    2014-06-01

    The authors report a 64-year-old man who developed persistent direction fixed nystagmus after a canalith repositioning maneuver for horizontal canal benign paroxysmal positional vertigo (HC-BPPV). The patient was initially diagnosed with right HC-BPPV given that the Dix-Hallpike test showed geotropic horizontal nystagmus that was more pronounced on the right side, although the roll test did not show any positional nystagmus. The patient was treated with a canalith repositioning maneuver (Lempert maneuver). The next day, the patient experienced a different character of dizziness, and left-beating spontaneous nystagmus regardless of head position was observed. After a forced prolonged left decubitus and frequent head shaking, his symptoms and nystagmus resolved. This condition, referred to as canalith jam, can be a complication after the repositioning maneuver in patients with BPPV. Atypical positional tests suggest that abnormal canal anatomy could be the underlying cause of canalith jam.

  6. Biomechanical Evaluation of Different Fixation Methods for Mandibular Anterior Segmental Osteotomy Using Finite Element Analysis, Part One: Superior Repositioning Surgery.

    Science.gov (United States)

    Kilinç, Yeliz; Erkmen, Erkan; Kurt, Ahmet

    2016-01-01

    The aim of the current study was to comparatively evaluate the mechanical behavior of 3 different fixation methods following various amounts of superior repositioning of mandibular anterior segment. In this study, 3 different rigid fixation configurations comprising double right L, double left L, or double I miniplates with monocortical screws were compared under vertical, horizontal, and oblique load conditions by means of finite element analysis. A three-dimensional finite element model of a fully dentate mandible was generated. A 3 and 5 mm superior repositioning of mandibular anterior segmental osteotomy were simulated. Three different finite element models corresponding to different fixation configurations were created for each superior repositioning. The von Mises stress values on fixation appliances and principal maximum stresses (Pmax) on bony structures were predicted by finite element analysis. The results have demonstrated that double right L configuration provides better stability with less stress fields in comparison with other fixation configurations used in this study.

  7. DOE-EPRI On-Line Monitoring Implementation Guidelines

    Energy Technology Data Exchange (ETDEWEB)

    E. Davis, R. Bickford

    2003-01-02

    Industry and EPRI experience at several plants has shown on-line monitoring to be very effective in identifying out-of-calibration instrument channels or indications of equipment-degradation problems. The EPRI implementation project for on-line monitoring has demonstrated the feasability of on-line monitoring at several participating nuclear plants. The results have been very enouraging, and substantial progress is anticipated in the coming years.

  8. An on-line method in studying music parsing.

    Science.gov (United States)

    Berent, I; Perfetti, C A

    1993-03-01

    Listening to music entails the construction of a mental representation based on partial and ambiguous information. This study examines an experimental method that reflects such parsing decisions on-line by detecting the cognitive load resulting from temporary parsing failures. The method investigated was a divided attention paradigm in which listening to music was the primary task and click detection was a concurrent secondary task. It was hypothesized that increasing the complexity of the primary task by introducing an unprepared chromatic modulation results in an increase in response latencies to a click presented immediately after the modulatory shift. The support of this prediction by musicians' data provides evidence for the sensitivity of the paradigm. The failure of non-musicians to reflect the expected load is attributed to their attention-allocation strategy. These results are discussed in terms of their implications on the view of the musical parser as deterministic.

  9. 3rd Computer Science On-line Conference

    CERN Document Server

    Senkerik, Roman; Oplatkova, Zuzana; Silhavy, Petr; Prokopova, Zdenka

    2014-01-01

    This book is based on the research papers presented in the 3rd Computer Science On-line Conference 2014 (CSOC 2014).   The conference is intended to provide an international forum for discussions on the latest high-quality research results in all areas related to Computer Science. The topics addressed are the theoretical aspects and applications of Artificial Intelligences, Computer Science, Informatics and Software Engineering.   The authors provide new approaches and methods to real-world problems, and in particular, exploratory research that describes novel approaches in their field. Particular emphasis is laid on modern trends in selected fields of interest. New algorithms or methods in a variety of fields are also presented.   This book is divided into three sections and covers topics including Artificial Intelligence, Computer Science and Software Engineering. Each section consists of new theoretical contributions and applications which can be used for the further development of knowledge of everybod...

  10. A versatile apparatus for on-line emission channeling experiments

    CERN Document Server

    da Silva, Manuel Ribeiro; Correia, João Guilherme; Amorim, Lígia Marina; Pereira, Lino Miguel da Costa

    2013-01-01

    The concept and functionality of an apparatus dedicated to emission channeling experiments using short-lived isotopes on-line at ISOLDE/CERN is described. The setup is assembled in two functional blocks - (a) base stand including beam collimation, implantation and measurement chamber, cryogenic extension, and vacuum control system and - (b) Panmure goniometer extension including maneuvering cradle and sample heating furnace. This setup allows for in situ implantation and sample analysis in the as-implanted state and upon cooling down to 50 K and during annealing up to 1200 K. The functionality of the setup will be illustrated with the example of establishing the lattice location of $^{56}$Mn probes implanted into GaAs.

  11. On-line control of the nonlinear dynamics for synchrotrons

    Science.gov (United States)

    Bengtsson, J.; Martin, I. P. S.; Rowland, J. H.; Bartolini, R.

    2015-07-01

    We propose a simple approach to the on-line control of the nonlinear dynamics in storage rings, based on compensation of the nonlinear resonance driving terms using beam losses as the main indicator of the strength of a resonance. The correction scheme is built on the analysis of the resonance driving terms in first perturbative order and on the possibility of using independent power supplies in the sextupole magnets, which is nowadays present in many synchrotron light sources. Such freedom allows the definition of "smart sextupole knobs" attacking each resonance separately. The compensation scheme has been tested at the Diamond light source and proved to be effective in opening up the betatron tune space, resonance free, available to the electron beam and to improve the beam lifetime.

  12. Parity Codes Used for On-Line Testing in FPGA

    Directory of Open Access Journals (Sweden)

    P. Kubalík

    2005-01-01

    Full Text Available This paper deals with on-line error detection in digital circuits implemented in FPGAs. Error detection codes have been used to ensure the self-checking property. The adopted fault model is discussed. A fault in a given combinational circuit must be detected and signalized at the time of its appearance and before further distribution of errors. Hence safe operation of the designed system is guaranteed. The check bits generator and the checker were added to the original combinational circuit to detect an error during normal circuit operation. This concurrent error detection ensures the Totally Self-Checking property. Combinational circuit benchmarks have been used in this work in order to compute the quality of the proposed codes. The description of the benchmarks is based on equations and tables. All of our experimental results are obtained by XILINX FPGA implementation EDA tools. A possible TSC structure consisting of several TSC blocks is presented. 

  13. Larval zebrafish model for FDA-approved drug repositioning for tobacco dependence treatment.

    Directory of Open Access Journals (Sweden)

    Margot A Cousin

    Full Text Available Cigarette smoking remains the most preventable cause of death and excess health care costs in the United States, and is a leading cause of death among alcoholics. Long-term tobacco abstinence rates are low, and pharmacotherapeutic options are limited. Repositioning medications approved by the U.S. Food and Drug Administration (FDA may efficiently provide clinicians with new treatment options. We developed a drug-repositioning paradigm using larval zebrafish locomotion and established predictive clinical validity using FDA-approved smoking cessation therapeutics. We evaluated 39 physician-vetted medications for nicotine-induced locomotor activation blockade. We further evaluated candidate medications for altered ethanol response, as well as in combination with varenicline for nicotine-response attenuation. Six medications specifically inhibited the nicotine response. Among this set, apomorphine and topiramate blocked both nicotine and ethanol responses. Both positively interact with varenicline in the Bliss Independence test, indicating potential synergistic interactions suggesting these are candidates for translation into Phase II clinical trials for smoking cessation.

  14. Correlation between Trunk Posture and Neck Reposition Sense among Subjects with Forward Head Neck Postures

    Directory of Open Access Journals (Sweden)

    Han Suk Lee

    2015-01-01

    Full Text Available Objective. To assess the correlation of abnormal trunk postures and reposition sense of subjects with forward head neck posture (FHP. Methods. In all, postures of 41 subjects were evaluated and the FHP and trunk posture including shoulder, scapular level, pelvic side, and anterior tilting degrees were analyzed. We used the head repositioning accuracy (HRA test to evaluate neck position senses of neck flexion, neck extension, neck right and left side flexion, and neck right and left rotation and calculated the root mean square error in trials for each subject. Spearman’s rank correlation coefficients and regression analysis were used to assess the degree of correlation between the trunk posture and HRA value, and a significance level of α = 0.05 was considered. Results. There were significant correlations between the HRA value of right side neck flexion and pelvic side tilt angle (p<0.05. If pelvic side tilting angle increases by 1 degree, right side neck flexion increased by 0.76 degrees (p=0.026. However, there were no significant correlations between other neck motions and trunk postures. Conclusion. Verifying pelvic postures should be prioritized when movement is limited due to the vitiation of the proprioceptive sense of neck caused by FHP.

  15. Impacted maxillary canine on the position of the central incisor: surgical-orthodontic repositioning.

    Science.gov (United States)

    Farronato, G; Giannini, L; Folegatti, C; Brotto, E; Galbiati, G; Maspero, C

    2013-04-01

    The aim of this article is to describe a case of a young orthodontic patient in which an impacted maxillary canine was repositioned in the central incisor position. A severe resorption of the root of the central right maxillary incisor by ectopic eruption of the impacted right maxillary canine is described. The canine was repositioned in the incisor's position to avoid resorption of the roots of the adjacent teeth during the disinclusion. The central incisor was extracted and the canine was extruded by a closed eruption technique. When the canine eruption was complete, the tip, the torque and the morphology of the canine were modified in order to make it look like an incisor. Nowadays the therapy with dental implants is the best choice, if the position of impacted teeth is difficult to reach. This case report describes a successful management of an impacted upper right canine aligned in the upper right central incisor position. Accurate diagnosis, conservative management of the soft tissues, anchorage unit and the direction of the orthodontic traction are important factors for the success treatment.

  16. Drug Repositioning Discovery for Early- and Late-Stage Non-Small-Cell Lung Cancer

    Directory of Open Access Journals (Sweden)

    Chien-Hung Huang

    2014-01-01

    Full Text Available Drug repositioning is a popular approach in the pharmaceutical industry for identifying potential new uses for existing drugs and accelerating the development time. Non-small-cell lung cancer (NSCLC is one of the leading causes of death worldwide. To reduce the biological heterogeneity effects among different individuals, both normal and cancer tissues were taken from the same patient, hence allowing pairwise testing. By comparing early- and late-stage cancer patients, we can identify stage-specific NSCLC genes. Differentially expressed genes are clustered separately to form up- and downregulated communities that are used as queries to perform enrichment analysis. The results suggest that pathways for early- and late-stage cancers are different. Sets of up- and downregulated genes were submitted to the cMap web resource to identify potential drugs. To achieve high confidence drug prediction, multiple microarray experimental results were merged by performing meta-analysis. The results of a few drug findings are supported by MTT assay or clonogenic assay data. In conclusion, we have been able to assess the potential existing drugs to identify novel anticancer drugs, which may be helpful in drug repositioning discovery for NSCLC.

  17. On-line monitoring of H2 generation and the HTF degradation in parabolic trough solar thermal power plants: Development of an optical sensor based on an innovative approach

    Science.gov (United States)

    Pagola, Iñigo; Funcia, Ibai; Sánchez, Marcelino; Gil, Javier; González-Vallejo, Victoria; Bedoya, Maxi; Orellana, Guillermo

    2017-06-01

    The work presented in this paper offers a robust, effective and economically competitive method for online detection and monitoring of the presence of molecular hydrogen in the heat transfer fluids of parabolic trough collector plants. The novel method is based on a specific fluorescent sensor according to the ES2425002 patent ("Method for the detection and quantification of hydrogen in a heat transfer fluid").

  18. On-Line Wavelength Calibration of Pulsed Laser for CO2 Differential Absorption LIDAR

    Science.gov (United States)

    Xiang, Chengzhi; Ma, Xin; Han, Ge; Liang, Ailin; Gong, Wei

    2016-06-01

    Differential absorption lidar (DIAL) remote sensing is a promising technology for atmospheric CO2 detection. However, stringent wavelength accuracy and stability are required in DIAL system. Accurate on-line wavelength calibration is a crucial procedure for retrieving atmospheric CO2 concentration using the DIAL, particularly when pulsed lasers are adopted in the system. Large fluctuations in the intensities of a pulsed laser pose a great challenge for accurate on-line wavelength calibration. In this paper, a wavelength calibration strategy based on multi-wavelength scanning (MWS) was proposed for accurate on-line wavelength calibration of a pulsed laser for CO2 detection. The MWS conducted segmented sampling across the CO2 absorption line with appropriate number of points and range of widths by using a tunable laser. Complete absorption line of CO2 can be obtained through a curve fitting. Then, the on-line wavelength can be easily found at the peak of the absorption line. Furthermore, another algorithm called the energy matching was introduced in the MWS to eliminate the backlash error of tunable lasers during the process of on-line wavelength calibration. Finally, a series of tests was conducted to elevate the calibration precision of MWS. Analysis of tests demonstrated that the MWS proposed in this paper could calibrate the on-line wavelength of pulsed laser accurately and steadily.

  19. PROFILES AND PREFERENCES OF ON-LINE MILLENIAL SHOPPERS IN BULGARIA

    Directory of Open Access Journals (Sweden)

    Patricia R. Loubeau

    2014-05-01

    Full Text Available This research seeks to develop a better understanding of the factors affecting on-line purchasing behavior among Generation Y (Gen Y consumers in Bulgaria. Also called millenials and born between the mid-1970s and late 1990s, this generation is especially active on-line and will be a dominant influence shaping e-commerce. An empirical study was conducted based on a written survey of a sample consisting of 367 high school and university students in Bulgaria. The most important reason why Bulgarian young people shop on-line is the pursuit of unique products not locally available, followed by convenience and better pricing, and their favorite category of internet purchases is “Apparel and Accessories.” Bulgarian millennials are using the internet to shop for trendy fashion and to obtain a variety of brands that are unavailable locally. Like other regions of the world, concern about financial transactions security is a major barrier limiting the willingness to shop on-line in Bulgaria. Unlike other markets where on-line music purchases are growing, high levels of digital piracy in Bulgaria strongly discourage Bulgarian students from purchasing music on-line. One limitation of this study arises because of its reliance on a convenience sample of students from medium sized cities in Southern Bulgaria. Further research employing stratified random sampling across Bulgaria is needed to assess whether the findings are broadly generalizable for the Gen Y population.

  20. Student apathy for classroom learning and need of repositioning in present andragogy in Indian dental schools

    Directory of Open Access Journals (Sweden)

    Dable Rajani A

    2012-11-01

    Full Text Available Abstract Background In the world of technology, when today's student is approaching the on-line /distance learning in the open universities and doing on-line self-assessment, the classroom learning is vanishing slowly. Globally, teachers are taking efforts to improve the pedagogy by implementing effective methods to retain the classroom teaching and student attendance. The present study aims at shedding some light on the need of changing the adult education strategies (andragogy, which can effectively improve the student attendance for lectures. Methods It is an observational study, and the conceptual framework of it is based on beliefs, opinions and personal experiences of the respondents. Triangulation method is used for collecting the data. The data is achieved from three groups of concerned population who could provide valid results to support the study. It is collected by interviewing 10 senior faculty members who are/were the 'education experts' in the universities, while the main concerned groups of present educational stream, i.e. 'institution-teachers' and the 'students', were given questionnaires. 570 teacher respondents and 200 student respondents are the main participants of this study. Results As per data, it has been observed that senior faculty (90% and students (93.25% feel need of student motivation more than the institutional teachers (52.44%. P-values were obtained using Chi-Square test for testing the significance of difference between agreement and disagreement for a specific question. Conclusions In India, Universities have already sensed the need of 'teacher development programmes'. But teachers in dental colleges, demand more efforts to be taken by universities and managements in this regard and expect better educational policies to give them accessibility to prove themselves.

  1. On-Line Databases in Mexico.

    Science.gov (United States)

    Molina, Enzo

    1986-01-01

    Use of online bibliographic databases in Mexico is provided through Servicio de Consulta a Bancos de Informacion, a public service that provides information retrieval, document delivery, translation, technical support, and training services. Technical infrastructure is based on a public packet-switching network and institutional users may receive…

  2. ON-LINE PREEMPTIVE SCHEDULING ON UNIFORM MACHINES

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yuzhong; WANG Shouyang; Bo Chen; ZHANG Shuxia

    2001-01-01

    We address the problem of preemptively schedule on-line jobs on arbitrary muniformly related machines with the objective of minimizing the schedule length. We provide the first on-line algorithm for this general problem, and show that the algorithm being the speeds of the m machines.

  3. From Off-line to On-line Handwriting Recognition

    NARCIS (Netherlands)

    Lallican, P.; Viard-Gaudin, C.; Knerr, S.

    2004-01-01

    On-line handwriting includes more information on time order of the writing signal and on the dynamics of the writing process than off-line handwriting. Therefore, on-line recognition systems achieve higher recognition rates. This can be concluded from results reported in the literature, and has been

  4. On-Line and Off-Line Assessment of Metacognition

    Science.gov (United States)

    Saraç, Seda; Karakelle, Sema

    2012-01-01

    The study investigates the interrelationships between different on-line and off-line measures for assessing metacognition. The participants were 47 fifth grade elementary students. Metacognition was assessed through two off-line and two on-line measures. The off-line measures consisted of a teacher rating scale and a self-report questionnaire. The…

  5. On-line optimal control of greenhouse crop cultivation.

    NARCIS (Netherlands)

    Straten, van G.

    1996-01-01

    Thus far, optimal control has primarily been investigated for seasonal crop growth optimization. On-line aspects have received much less attention. The decomposition between long term strategies and on-line control, however, is not trivial. Appreciable losses occur when set-points generated by seaso

  6. On-line optimal control of greenhouse crop cultivation.

    NARCIS (Netherlands)

    Straten, van G.

    1996-01-01

    Thus far, optimal control has primarily been investigated for seasonal crop growth optimization. On-line aspects have received much less attention. The decomposition between long term strategies and on-line control, however, is not trivial. Appreciable losses occur when set-points generated by seaso

  7. Review of Worcestershire On-line Fabric Type Series website

    Directory of Open Access Journals (Sweden)

    Beverley Nenk

    2003-06-01

    Full Text Available The study of archaeological ceramics is advanced through the creation and development of regional and national pottery type-series, which contain samples of each type of pottery identified from a particular area or region. Pottery researchers working in any period, from prehistoric to post-medieval, require access to such type-series, and to their associated data, in order to be able to advance the identification of all types of pottery, not only those types produced in the local area, but those produced in surrounding regions, as well as those imported from abroad. The publication of such type-series, as well as their accessibility to researchers, is essential if the information they contain is to be disseminated. The development of the Worcestershire On-Line Fabric Type Series is the first stage in a remarkable project designed to make the complete fabric and form type series for Worcestershire ceramics accessible on the internet. As part of the Historic Environment Record for Worcestershire, formerly the Sites and Monuments Record, it is designed to improve access to finds and environmental data, with the aim of encouraging and facilitating research. Funded by Worcestershire County Council as part of its commitment to e-government, it is being developed by Worcestershire County Council Archaeology Service with OxfordArchDigital. It is one of a proposed series of on-line specialist resources (to include, for example, clay pipes, environmental archaeology, flint tools, historic buildings, which are also designed to stand alone as research tools. The ceramics website is the first part of Pottery in Perspective, a web-based project to provide information on the pottery used and made in Worcestershire from prehistory to c. 1900AD.

  8. Algorithms for semi on-line multiprocessor scheduling problems

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    In the classical multiprocessor scheduling problems, it is assumed that the problems are considered in off-line or on-line environment. But in practice, problems are often not really off-line or on-line but somehow in between. This means that, with respect to the on-line problem, some further information about the tasks is available, which allows the improvement of the performance of the best possible algorithms. Problems of this class are called semi on-line ones. The authors studied two semi on-line multiprocessor scheduling problems, in which, the total processing time of all tasks is known in advance, or all processing times lie in a given interval. They proposed approximation algorithms for minimizing the makespan and analyzed their performance guarantee. The algorithms improve the known results for 3 or more processor cases in the literature.

  9. Research on Common Data Model of On-line Examination System Based on Oracle%在线考试系统通用数据模型研究

    Institute of Scientific and Technical Information of China (English)

    陈蓉; 陈烽; 孙懿

    2014-01-01

    Data model is the basis and core of database design. It is directly related to the success or failure of information man-agement system development. This paper studies database data model of online examination system based on the Oracle, and gives three common data models of online examination system based on oracle. It can give a certain reference value for common data mod-eling of the similar management system.%数据模型是数据库设计的基础和核心,它的好坏直接关系到信息管理系统开发的成功与失败。本文研究了在线考试系统的数据模型构建,给出了在线考试系统的三个通用数据模型。对同类管理系统的通用数据建模有一定的参考价值。

  10. Head repositioning errors in normal student volunteers: a possible tool to assess the neck's neuromuscular system

    Directory of Open Access Journals (Sweden)

    Gudavalli M Ram

    2006-03-01

    Full Text Available Abstract Background A challenge for practitioners using spinal manipulation is identifying when an intervention is required. It has been recognized that joint pain can interfere with the ability to position body parts accurately and that the recent history of muscle contraction can play a part in that interference. In this study, we tested whether repositioning errors could be induced in a normal population by contraction or shortening of the neck muscles. Methods In the experimental protocol, volunteers free of neck problems first found a comfortable neutral head posture with eyes closed. They deconditioned their cervical muscles by moving their heads 5 times in either flexion/extension or lateral flexion and then attempted to return to the same starting position. Two conditioning sequences were interspersed within the task: hold the head in an extended or laterally flexed position for 10 seconds; or hold a 70% maximum voluntary contraction in the same position for 10 seconds. A computer-interfaced electrogoniometer was used to measure head position while a force transducer coupled to an auditory alarm signaled the force of isometric contraction. The difference between the initial and final head orientation was calculated in 3 orthogonal planes. Analysis of variance (1-way ANOVA with a blocking factor (participants was used to detect differences in proprioceptive error among the conditioning sequences while controlling for variation between participants. Results Forty-eight chiropractic students participated: 36 males and 12 females, aged 28.2 ± 4.8 yrs. During the neck extension test, actively contracting the posterior neck muscles evoked an undershoot of the target position by 2.1° (p Conclusion The results suggest that the recent history of cervical paraspinal muscle contraction can influence head repositioning in flexion/extension. To our knowledge this is the first time that muscle mechanical history has been shown to influence

  11. INTERACTIVE 3D LANDSCAPES ON LINE

    Directory of Open Access Journals (Sweden)

    B. Fanini

    2012-09-01

    Full Text Available The paper describes challenges identified while developing browser embedded 3D landscape rendering applications, our current approach and work-flow and how recent development in browser technologies could affect. All the data, even if processed by optimization and decimation tools, result in very huge databases that require paging, streaming and Level-of-Detail techniques to be implemented to allow remote web based real time fruition. Our approach has been to select an open source scene-graph based visual simulation library with sufficient performance and flexibility and adapt it to the web by providing a browser plug-in. Within the current Montegrotto VR Project, content produced with new pipelines has been integrated. The whole Montegrotto Town has been generated procedurally by CityEngine. We used this procedural approach, based on algorithms and procedures because it is particularly functional to create extensive and credible urban reconstructions. To create the archaeological sites we used optimized mesh acquired with laser scanning and photogrammetry techniques whereas to realize the 3D reconstructions of the main historical buildings we adopted computer-graphic software like blender and 3ds Max. At the final stage, semi-automatic tools have been developed and used up to prepare and clusterise 3D models and scene graph routes for web publishing. Vegetation generators have also been used with the goal of populating the virtual scene to enhance the user perceived realism during the navigation experience. After the description of 3D modelling and optimization techniques, the paper will focus and discuss its results and expectations.

  12. On-line micro column preconcentration system based on amino bimodal mesoporous silica nanoparticles as a novel adsorbent for removal and speciation of chromium (III, VI) in environmental samples.

    Science.gov (United States)

    Shirkhanloo, Hamid; Khaligh, Aisan; Golbabaei, Farideh; Sadeghi, Zargham; Vahid, Amir; Rashidi, Alimorad

    2015-01-01

    Chromium (VI) has toxic and carcinogenic effects. So, determination and speciation of chromium in environmental samples is very important in view of health hazards. In this study, solid phase extraction (SPE) based on bulky amine-functionalized bimodal mesoporous silica nanoparticles (NH2-UVM-7) as a novel nanoadsorbent was applied for preconcentration and speciation of chromium (III, VI) in water samples. UVM-7 was synthesized via atrane route and subsequently functionalized with amino silane via grafting method. In SPE procedure, polymer tubing as a micro-column was filled with NH2-UVM-7 adsorbent. Preconcentration and speciation of Cr (III) and Cr (VI) ions with NH2-UVM-7 were obtained in water samples due to the fact that only Cr (VI) ions can be complexed with-NH2 groups at optimized pH. Finally, chromium concentration was determined by flame atomic absorption spectrometry (F-AAS). TEM, XRD, and SEM results confirmed the beneficial properties of NH2-UVM-7 as the adsorbent for chromium extraction. Under the optimal conditions, linear calibration curve, detection limit and preconcentration factor were obtained 6-320 μg/ L, 1.2 μg/L and 66.7, respectively (RSD < 5 %). The efficiency of nanoadsorbent for preconcentration and extraction of Cr (VI) was 96 %, whereas it was less than 5 % for Cr (III). The developed NH2-UVM7-based SPE/F-AAS method has enough sensitively and simplicity for speciation and determination of Cr (VI) and Cr (III) ions in real water samples. Good recoveries, with low detection limits and good preconcentration factors are the main advantages of this procedure.

  13. Determination of anions with an on-line capillary electrophoresis method; Anionien on-line maeaeritys kapillaarielektroforeesilla - MPKT 10

    Energy Technology Data Exchange (ETDEWEB)

    Siren, H.; Saerme, T.; Kotiaho, T.; Hiissa, T.; Savolahti, P.; Komppa, V. [VTT Chemical Technology, Espoo (Finland)

    1998-12-31

    The aim of the study was to set-up an on-line capillary electrophoresis method for determination of anions in process waters of pulp and paper industry with exporting the results to the process control system of the mill. The quantification is important, since it will give information about the possible causes of precipitation. In recent years, the capillary electrophoresis (CE) due to its high separation efficiency has been shown as a method to take into consideration when analyzing chemical species ranging from small inorganic anions to different macromolecules. Many compounds are not easily detected in their native state, why analysis methods must be developed to improve their detection. Especially, small inorganic and organic anions which do not have chromophores are not sensitive enough for direct-UV detection. In such analyses the anions are mostly detected with indirect-UV technique. Capillary electrophoresis instruments are used to analyze samples in off-line, which seldom represent the situation in process. Therefore, on-line instrument technology with autoanalyzing settings will be needed in quality control. The development of a fully automatic capillary electrophoresis system is underway in co-operation with KCL (The Finnish Pulp and Paper Research Institute). In our research, we have first concentrated on the determination of sulphate in waters of paper industry. The method used for detection of sulphate is based on indirect-UV detection with CE, where the background electrolyte (BGE) is an absorbing mixture of secondary amines. The whole procedure for quantification of sulphate is performed within 15 minutes, after which a new sample is analyzed automatically. The only sample pretreatment is filtration, which is necessary before analysis. The concentrations of sulphate in process waters tested were between 300 and 800 ppm. Our tests show that a simultaneous determination of chloride, sulphate, nitrate, nitrite, sulphite, carbonate and oxalate is also

  14. On the use of on-line detection for maintenance of gradually deteriorating systems

    Energy Technology Data Exchange (ETDEWEB)

    Fouladirad, Mitra [Institut Charles Delaunay, Universite de Technologie de Troyes, FRE CNRS 2848, LM2S 12 rue Marie Curie, 10010 Troyes (France); Grall, Antoine [Institut Charles Delaunay, Universite de Technologie de Troyes, FRE CNRS 2848, LM2S 12 rue Marie Curie, 10010 Troyes (France)], E-mail: antoine.grall@utt.fr; Dieulle, Laurence [Institut Charles Delaunay, Universite de Technologie de Troyes, FRE CNRS 2848, LM2S 12 rue Marie Curie, 10010 Troyes (France)

    2008-12-15

    This paper deals with condition-based maintenance and non-stationary degradation process due to sudden changes. This is an attempt to propose an adaptive maintenance policy based on the on-line change detection procedure which can help to detect switches from a nominal mode to an accelerated mode in a non-informative context about the change mode time.

  15. On-line performance evaluation based on index of dispersion and Markovian fitted model%基于离差指数和马尔可夫拟合模型的在线性能分析方法

    Institute of Scientific and Technical Information of China (English)

    王秀文; 曲海平; 许鲁

    2011-01-01

    Aiming at the problem that under the condition of coarse monitoring granularity and burst workloads, simple parameterization of traditional queueing models in terms of mean service time of incoming requests does not apply to accurate performance evaluation, this paper, oriented to autonomic resource scheduling, proposes a method for online performance analysis that is suitable for coarse monitoring granularity. This method adopts the Markovian fitting method based on the index of dispersion for counts (IDC ) which characterizes the burstiness of service time, and based on the fitted Markovian model, develops the Markovian arrival process (MAP) queueing network to analyze the performance indexes online. The experimental results show that the proposed method is more accurate in performance analysis than that of solving traditional queueing networks by the Mean Value Analysis (MVA). Taking the response time and the throughput for example, compared with the traditional MVA method, the relative errors of the proposed method respectively lower 6.38% and 6.27% on the average. The maximum values can be 11.45% and 15.06%.%针对粗监控粒度和突发性负载的情况下传统的基于平均服务时间的排队模型的性能分析不准确的问题,提出了一种适用于粗监控粒度的在线性能分析方法.该方法采用基于请求数目离差指数( IDC)的马尔可夫拟合技术,利用IDC描述服务时间过程的突发性,在马尔可夫拟合模型的基础上构建有效的排队网络.试验结果表明,与传统的采用均值分析(MVA)方法求解的排队模型相比,该方法更准确.以性能参数响应时间和吞吐量为例,相对误差分别平均降低了6.38%和6.27%,最大可降低11.45%和15.06%.

  16. 基于GMDH算法的配电网线损数据预处理研究%Research on line loss data pretreatment in distribution network based on GMDH algorithm

    Institute of Scientific and Technical Information of China (English)

    何艺; 陈俊

    2015-01-01

    According to the line loss calculation characteristics of distribution network, and the conditions of data missing and data abnormalities, the pretreatment model of line loss data pretreatment in distribution network based on group method of data handing (GMDH) algorithm is established, which can handle the abnormal data. The upper and lower limit of dependent variable and independent variable are determined based on k-nearest neighbors algorithm in the model, random interpolation and data packet processing model of all variables is established. The optimal GMDH model is searched and the missing value is calculated under iteration cycle. Experimental results show that the model has small calculations results error and fast computing speed, which can effectively and dynamically update missing line loss data, and optimize line loss calculation and analysis results.%针对当前配电网线损计算的特点及数据存在缺失、异常等情况,基于数据分组处理算法(GMDH)建立了配电网线损缺失数据的预处理模型,实现对线损缺失数据的预处理。模型基于最邻近算法确定因变量和自变量缺失值的上下限,并进行随机插补,建立所有变量的数据分组处理模型,寻找最优复杂度模型,计算缺失值并进行迭代循环。算例结果表明,模型计算结果误差小、运算速度快,对缺失的线损数据能进行有效的动态更新,提升了数据质量,优化线损计算分析结果。

  17. "What Sort of Person Ought I to Be?"--Repositioning EPs in Light of the Children and Families Bill (2013)

    Science.gov (United States)

    Fox, Mark

    2015-01-01

    The changes brought by the Special Educational Needs and Disability (SEND) code of practice: 0 to 25 years, 2014, is an opportunity for educational psychologists (EPs) to reposition ourselves so that we can improve our contribution to the services for children and young people with special educational needs (SENs) or a disability. Underpinning…

  18. Effect of the different ages and visual display terminal use on repositioning and lumbar muscle activity during continuous sitting.

    Science.gov (United States)

    Yoo, Won-Gyu

    2016-03-01

    [Purpose] The purpose of this study was to investigate the effect of different ages and visual display terminal (VDT) use on repositioning and lumbar muscle activity during continuous sitting. [Subjects] Thirteen males two groups: 7 males in their 20s, 6 males in their 40s participated in this study. [Methods] The two groups watched a lecture in a seated position under different conditions. L4 paraspinal muscle activity was recorded using a surface electromyography system. Repositioning was assessed using a video camera and Tekscan system. [Results] The repositioning times decreased significantly in the order to without a VDT in males in their 20s and 40s > with a VDT in males in their 20s > with a VDT in males in their 40s. The L4 paraspinal muscle activity significantly increased in order to without a VDT in males in their 20s and 40s < with a VDT in males in their 20s < with a VDT in males in their 40s. [Conclusion] The results of this study suggest that the number of repositioning movements during continuous sitting could affect lumbar muscle activity and could be an important factor for prevention of low back pain.

  19. Study of Online Detection Blast Furnace Temperature Sensor Based on Lining Thickness%基于炉衬厚度的高炉炉温在线检测传感器

    Institute of Scientific and Technical Information of China (English)

    王月明; 孙采鹰; 董大明; 贾华

    2015-01-01

    This paper described the background of the blast furnace temperature online measurement applications and analyzed the study progress of existing blast furnace temperature measurements, then proposed two blast furnace temperature online meas-urement sensor models based on the thickness of lining, which provided a new solution for the blast furnace temperature measure-ments.The sensor model of blast furnace temperature online detection enriched blast furnace expert system database, correctly ad-justed control parameters of blast furnace, maintained blast furnace temperature in the best condition, ensured anterograde smooth working of blast furnace conditions, and increased the life of the blast furnace.%介绍了高炉测温的应用背景,分析现有高炉炉温测量研究情况,提出了两种基于炉衬厚度的高炉炉温在线检测传感器模型,为高炉炉内温度测量提供一种新的解决方案。基于炉衬厚度的高炉炉温在线检测传感器模型能够充实和丰富高炉专家系统数据库规则制定中的参数,可以指导高炉工长及时正确地调节高炉控制参数,把炉温保持在最佳状态,保证炉况平稳顺行,以延长高炉寿命。

  20. 基于Web框架的科技项目申报系统的设计与实现%Design and Implementation of Technological Project On-line Declaration System Based on Web Framework

    Institute of Scientific and Technical Information of China (English)

    卢燕儿; 武友新

    2009-01-01

    Lightweight J2EE (Struts+Spring+Hibernate) as a popular J2EE development framework in recent years, not only focuses on reducing the complexity of code, but also tries to avoid unnecessary complexity in developing their own functions. In this paper, according to status of the current project with the declaration, examination and approval, it takes the MVC design pattern that widespread used currently, combines with the characteristics of the management system, uses the technology of framework integration, proposes the project declaration system solutions based on the multi-layered framework. It uses the multi-level architecture to divide the platform layer into customer layer, Web layer, application layer and EIS layer. Compares with the traditional declaration the system is more flexibility, reusability and maintainability.%轻量级J2EE(Struts+Spring+Hibernate)作为近年来流行的J2EE开发框架,不仅专注于减少程序代码的复杂性,而且还尽量避免在自身的功能实现中引入不必要的复杂性.本文根据当前项目申报、审批、管理的现状,采用目前广泛流行的MVC设计模式,结合项目申报管理系统特点,应用这种框架整合的技术,提出基于J2EE多层框架的项目申报系统的解决方案,采用多层次的体系结构,将平台分为客户层、Web层、应用层和EIS层,与传统的项目申报相比,提高了系统灵活性、可复用性和可维护性.

  1. On-line Supervised Adaptive Training Using Radial Basis Function Networks.

    Science.gov (United States)

    Luo, Wan; Billings, Steve A.; Fung, Chi F.

    1996-12-01

    A new recursive supervised training algorithm is derived for the radial basis neural network architecture. The new algorithm combines the procedures of on-line candidate regressor selection with the conventional Givens QR based recursive parameter estimator to provide efficient adaptive supervised network training. A new concise on-line correlation based performance monitoring scheme is also introduced as an auxiliary device to detect structural changes in temporal data processing applications. Practical and simulated examples are included to demonstrate the effectiveness of the new procedures. Copyright 1996 Elsevier Science Ltd.

  2. On-line Resources for Teaching Sustainability

    Science.gov (United States)

    Bruckner, M. Z.; Larsen, K.; Buhr, S. M.; Kirk, K. B.; Ledley, T. S.; Manduca, C. A.; Mogk, D. W.; Savina, M. E.; Tewksbury, B. J.

    2012-12-01

    sustainability are presented in the portal, including service learning, campus-based learning, experience-based environmental projects, and teaching with an Earth systems approach. Faculty can find more information about how to get involved with sustainability projects through webinars, workshops, web page authoring, and other professional development opportunities via links to projects such as On the Cutting Edge, CLEAN, and InTeGrate. The Sustainability Portal also provides access to materials generated from previous workshops, featuring interdisciplinary visions for teaching sustainability to undergraduate students. The SERC portal for Teaching Sustainability can be found at the URL below.

  3. Can stimulating massage improve joint repositioning error in patients with knee osteoarthritis?

    DEFF Research Database (Denmark)

    Lund, Hans; Henriksen, Marius; Bartels, Else M

    2009-01-01

    PURPOSE: The purpose of this study was to investigate the effect of massage applied to the thigh muscles on joint repositioning error (JRE) in patients suffering from osteoarthritis (OA).We hypothesized that stimulating massage of the muscles around an osteoarthritic knee joint, could improve...... the neuromuscular function and thereby optimize the positive and minimize the negative performance factors in relation to an exercise program. METHODS: In a cross-over design, 19 patients with knee osteoarthritis, mean age of 73.1 years (SD: 9.4; range 56 to 88 years), recruited from the local department...... with knee osteoarthritis, ie, if an improved JRE is important for improving the performance factors when exercising, stimulating massage may not be recommendable to use....

  4. Management of benign paroxysmal positional vertigo with the canalith repositioning maneuver in the emergency department setting.

    Science.gov (United States)

    Burmeister, David B; Sacco, Regina; Rupp, Valerie

    2010-10-01

    Vertigo is a common clinical manifestation in the emergency department (ED). It is important for physicians to determine if the peripheral cause of vertigo is benign paroxysmal positional vertigo (BPPV), a disorder accounting for 20% of all vertigo cases. However, the Dix-Hallpike test--the standard for BPPV diagnosis--is not common in the ED setting. If no central origin of the vertigo is determined, patients in the ED are typically treated with benzodiazepine, antihistamine, or anticholinergic agents. Studies have shown that these pharmaceutical treatment options may not be the best for patients with BPPV. The authors describe a case of a 38-year-old woman who presented to the ED with complaints of severe, sudden-onset vertigo. The patient's BPPV was diagnosed by means of a Dix-Hallpike test and the patient was acutely treated in the ED with physical therapy using the canalith repositioning maneuver.

  5. Frenectomy with semilunar coronally repositioned flap: A single stage approach - simple solution for complex problem.

    Science.gov (United States)

    Deshmukh, Jeevanand; Khatri, Richa; Fernandes, Bennete; Kulkarni, Vinaya Kumar; Singh, Shubhra

    2015-01-01

    Gingival recession is defined as the displacement of gingival margin apical to cementoenamel junction. Aberrant frenum attachment can contribute to the progression of recession by generating tension on the marginal tissues. Treating such defects is a two stage procedure-frenectomy and recession coverage procedure. New techniques are developed to increase the predictability, reduce patient discomfort and number of surgical sites. Also, these techniques try to satisfy patients esthetic demands, which include the final colour and tissue blend of the covered area. In this case report, we present a method for coronally repositioning gingiva for root coverage over the maxillary central incisors while simultaneously performing a frenectomy, thus being clinically advantageous compared to two-stage technique.

  6. 光纤陀螺随机漂移在线建模实时滤波技术%Real-time Filtering Research Based on On-line Modeling Random Drift of FOG

    Institute of Scientific and Technical Information of China (English)

    金毅; 吴训忠; 谢聂; 郭创

    2015-01-01

    Establishing the model of FOG’s random drift and compensating in the filter is an effective method to improve the output precision of FOG. For traditional random drift of fiber optical gyroscope has some shortages like off-line, needing pre-process and the off-line models, which are usually not universal for environmental changing, a new modeling and filtering way is put forward. First, based on a large amount of measured data, the traditional off-line AR model is improved, and a new method to build the model of FOG’s random drift is studied. Then, the comparison is made between the traditional Kalman filter andH∞ filter in real time. The result demonstrates that improved AR model has much applicability and the performance ofH∞ filter is better than Kalman filter. The minimum value of fitting accuracy is 91.6% andH∞ filter can improve the performance of filtering by almost 38.5% when analyzing ingle noise.%建立光纤陀螺随机漂移模型以便在滤波中加以补偿是提高光纤陀螺输出精度的有效方法。针对传统光纤陀螺随机漂移建模均采用离线形式,需预先处理数据,不具备普适性等问题,提出一种实时的建模滤波方法。首先,根据大量实测数据对传统离线模型进行改进,研究了一种基于AR模型的在线建立光纤陀螺随机漂移模型的方法。然后,比较了传统Kalman滤波器与H∞滤波器用于实时滤波的效果。实验结果表明,改进型AR模型拟合精度高、普适性强,单个噪声拟合精度最低值为91.6%。H∞滤波器效果优于传统的 Kalman 滤波器,分析单个噪声滤波效果时,H∞滤波器较Kalman滤波器性能最多可提高38.5%。

  7. ON-LINE ELIMINATION OF OIL WHIP

    Institute of Scientific and Technical Information of China (English)

    Zheng Shuiying; Liu Shulian

    2005-01-01

    A new method to eliminate the oil whip online is put forward by use of passive electromagnetic damper. The damper works contactless and with DC current. Neither sensor nor closed loop control is needed. The dynamic equations of rotor-bearing system are built up by combining d'Alemdert principle with Rize way, and the nonlinear oil film forces based on unsteady short bearing model are coupled to system. Such nonlinear equations are numerically solved by Newmark integration method. The calculated results show that the bifurcation behavior of the system can be changed and the oil whip of the rotor may be well damped by external damping. The bifurcation diagrams also show that the subharmonic vibration amplitude decreases in motion and the speed at which the system losses its stability increases obviously by exerting external damping.Then experiments are carried out to demonstrate this phenomenon. It is observed that the complex trajectories of the journal motion are disappeared and the rotor-bearing system became stable when the power of passive electromagnetic damper is turned on. The experiments have good repeatability.

  8. Residual dizziness after successful repositioning maneuvers for idiopathic benign paroxysmal positional vertigo in the elderly.

    Science.gov (United States)

    Teggi, Roberto; Giordano, Leone; Bondi, Stefano; Fabiano, Beatrice; Bussi, Mario

    2011-04-01

    Even after successful repositioning maneuvers for benign paroxysmal positional vertigo (BPPV), some patients report dizziness lasting for a certain period afterwards. We studied the prevalence and clinical factors associated with residual dizziness in a sample of elderly patients. Sixty outpatients over 65 years of age, affected by idiopathic BPPV were recruited; the exclusion criterion was a history of previous episodes of vertigo, including positional. The patients were asked to describe their self-perceived anxiety for vertigo on a Visual Analogue Scale (VAS) and successively treated with appropriate maneuvers till resolution of nystagmus. Data concerning the demographic and clinical features of BPPV were collected. Patients were followed until complete resolution of subjective dizziness and imbalance without positional nystagmus. Data about residual dizziness were collected from the second day from resolution of BPPV. Clinical and demographic factors related to residual dizziness were analyzed. Twenty-two subjects (37%) reported residual dizziness. In these subjects, the mean duration of residual dizziness was 13.4 ± 7.5 days. No association was observed between residual dizziness and gender, involved canal and the number of repositioning maneuvers before resolution. On the other hand, age older than 72 years, symptom duration greater than 9 days and VAS scale for anxiety greater than 10/100 were associated with an increased risk of residual dizziness. The odds ratio were respectively 6.5 (age-residual dizziness, Confidence Interval 95%), 6.5 (duration of vertigo-residual dizziness, Confidence Interval 95%) and 15.5 (anxiety levels-residual dizziness, Confidence Interval 95%). Longer symptom duration before diagnosis was associated with higher anxiety levels. The results underline the necessity for an early and correct diagnosis of BPPV, especially in the elderly.

  9. On-line Monitoring System of Insulator Leakage Current Based on ARM%基于ARM的绝缘子泄漏电流在线监测系统设计

    Institute of Scientific and Technical Information of China (English)

    姜小丰; 胡晓光; 左廷涛

    2011-01-01

    A ceramic insulator has an excellent anti-pollution properties, but sometimes flashover occurs on it and then the outage of power network follows. This paper analyzes the formation mechanism of flashover and the result is that the RMS of leakage current (LC) and discharge pulses reflect the contamination severity approximately. This shows that to a large extent the flashover accident can be avoided by means of monitoring the leakage current value and the discharge pulses. Existing monitoring device for contaminated insulators inspects either leakage currents or discharge pulses, also,it is difficult to meet the requirements of the client for low-power consumption, low cost and high reliability. In this paper, a novel low-power and low-cost online monitoring system is presented, which is based on ARM Cortex-M and Zigbee wireless network high-voltage insulator leakage current. In addition, the monitoring system not only acquires the leakage current and discharge pulses of insulator strings, but also measures the environmental temperature and humidity and then comprehensively analyzes the severity of insulator pollution. After that the results will be displayed on the LCD or sent to the control center through the Zigbee network. Tests show that the monitoring system has good accuracy and good practical performance.%陶瓷绝缘子具有良好的防污特性,但也会发生污秽闪络,导致供电中断.文中分析了污闪的形成机理,认为绝缘子泄漏电流有效值和放电脉冲数可在一定程度上反映出其表面的污秽程度,从而可通过监测泄漏电流值及电脉冲数的方法来有效避免污闪事故的发生.现有的监测装置一般只监测泄漏电流值或电脉冲数中的一项参数,且其功耗和性能都难以达到实用要求,为此,该文设计了一种基于ARM Cortex控制器及Zigbee无线网络的高压绝缘子泄漏电流在线监测系统,系统实时采集绝缘子表面泄漏电流、电脉冲数及环境温

  10. 基于扩展磁链的永磁同步牵引电机失磁在线监测%On-line Demagnetization Detection of Permanent Magnet Synchronous Traction Motor Based on Extended Flux Linkage

    Institute of Scientific and Technical Information of China (English)

    黄刚; 罗意平; 张昌凡; 赵凯辉

    2016-01-01

    An online permanent magnet demagnetization failures detection method based on a minimum order ex‐tended flux linkage sliding mode observer was presented for torque closed‐loop control system of interior per‐manent magnet synchronous traction motor . After the establishment of a mathematical model in the two‐phase stationary reference frame for the demagnetization fault ,a variable rate reaching law sliding mode observer was built by using the extended flux linkage as state variables , to realize the reconstruction of torque and perma‐nent magnet flux linkage . The estimation method can accurately track the torque and permanent magnet flux linkage , with a shorter transient time , smaller overshoot in the dynamic process of the system , higher obser‐vation precision and stronger system robustness , It can offer real‐time accurate torque feedback and permanent magnet flux linkage information for the improvement of the control performance and reliability of the traction drive system of the permanent magnet synchronous motor . Then the RT‐LAB real‐time simulation was used to build the simulation model of hardware in the loop . The simulation and experimental results demonstrated the feasibility and effectiveness of the proposed method .%针对内置式永磁同步牵引电机转矩闭环控制系统,提出一种基于最小阶扩展磁链滑模变结构观测器的永磁体失磁在线监测方法。通过建立两相静止坐标系下永磁同步牵引电机失磁故障的数学模型,以扩展磁链为状态变量,构建变速趋近律滑模状态观测器,实现了转矩和永磁体磁链的重构。该方法能够准确观测转矩和永磁体磁链信息,系统动态响应速度快,动态过程超调小,观测精度高,系统鲁棒性更强,可为提高永磁同步电机牵引传动系统的控制性能和可靠性实时提供准确的转矩反馈和转子磁链信息。基于RT‐LAB搭建了硬件在环仿真试验系统,

  11. On-Line Life Monitoring Technique for Tube Bundles of Boiler High-Temperature Heating Surface

    Institute of Scientific and Technical Information of China (English)

    Yang Dong; Wang Zhongyuan

    2005-01-01

    High-temperature heating surface such as superheater and reheater of large-sized utility boiler all experiences a relatively severe working conditions. The failure of boiler tubes will directly impact the safe and economic operation of boiler. An on-line life monitoring model of high-temperature heating surface was set up according to the well-known L-M formula of the creep damages. The tube wall metal temperature and working stress was measured by on-line monitoring, and with this model, the real-time calculation of the life expenditure of the heating surface tube bundles were realized. Based on the technique the on-line life monitoring and management system of high-temperature heating surface was developed for a 300 MW utility boiler. An effective device was thus suggested for the implementation of the safe operation and the condition-based maintenance of utility boilers.

  12. Research of on-line monitoring method for insulation condition of power transformer bushing

    Science.gov (United States)

    Xia, Jiuyun; Qian, Zheng; Yu, Hao; Yao, Junda

    2016-01-01

    The power transformer is the key equipment of the power system; its insulation condition will directly influence the security and reliability of the power system. Thus, the on-line monitoring of power transformer is urgently required in order to guarantee the normal operation of the power system. Moreover, the dielectric loss factor is a significant parameter reflecting the condition of transformer bushing, so the on-line measurement of dielectric loss factor is really important. In this paper, the phase-to-phase comparison method is selected as the on-line monitoring method based on the overall analysis and discussion of the existing on-line monitoring methods. At first, the harmonic analysis method is utilized to calculate the dielectric loss of each phase of the three-phase transformer bushing, and then the differences of dielectric loss between every two phases are calculated and analyzed. So the insulation condition of each bushing could be achieved based on the careful analysis of different phase-to-phase dielectric loss. The simulation results of phase-to-phase comparison method are carried out in this paper, and the validity is verified. At last, this method is utilized in an actual equipment of on-line monitoring.

  13. The Effect of a Condylar Repositioning Plate on Condylar Position and Relapse in Two-Jaw Surgery

    Science.gov (United States)

    Jung, Gyu Sik; Kim, Taek Kyun; Lee, Jeong Woo; Yang, Jung Dug; Chung, Ho Yun; Cho, Byung Chae

    2017-01-01

    Background Numerous condylar repositioning methods have been reported. However, most of them are 2-dimensional or are complex procedures that require a longer operation time and a highly trained surgeon. This study aims to introduce a new technique using a condylar repositioning plate and a centric relation splint to achieve a centric relationship. Methods We evaluated 387 patients who had undergone surgery for skeletal jaw deformities. During the operation, a centric relation splint, intermediate splint, final centric occlusion splint, and condylar repositioning plate along with an L-type mini-plate for LeFort I osteotomy or a bicortical screw for bilateral sagittal split ramus osteotomy were utilized for rigid fixation. The evaluation included: a physical examination to detect preoperative and postoperative temporomandibular joint dysfunction, 3-dimensional computed tomography and oblique transcranial temporomandibular joint radiography to measure 3-dimensional condylar head movement, and posteroanterior and lateral cephalometric radiography to measure the preoperative and postoperative movement of the bony segment and relapse rate. Results A 0.3% relapse rate was observed in the coronal plane, and a 2.8% relapse rate in the sagittal plane, which is indistinguishable from the dental relapse rate in orthodontic treatment. The condylar repositioning plate could not fully prevent movement of the condylar head, but the relapse rate was minimal, implying that the movement of the condylar head was within tolerable limits. Conclusions Our condylar repositioning method using a centric relation splint and mini-plate in orthognathic surgery was found to be simple and effective for patients suffering from skeletal jaw deformities. PMID:28194343

  14. On-line Classical Guitar Course: Blogs for Music Education

    OpenAIRE

    José Luis Navarro; Gilles Lavigne; G. Guadalupe Martínez Salgado

    2009-01-01

    This article introduces an on-line course constructed by means of a blog. The tool was the main goal of a research project titled “Develop, Implementation and evaluation of a Hybrid Course Face to face-On Line for Teaching the Beginning to Play the Classical Guitar”. This work was a three steep project in which it was implemented, applied and evaluated. The on-line course was intended to prepare the students to learn the basic principles to start in classical music with the guitar. The result...

  15. Understanding on-line community: the affordances of virtual space

    Directory of Open Access Journals (Sweden)

    Karen Ruhleder

    2002-01-01

    Full Text Available Increasing numbers of on-line venues for learning are emerging as virtual communities become more accessible and commonplace. This paper looks at one particular virtual community, an on-line degree programme at the University of Illinois, Urbana-Champaign, which offers an M.S. in Library and Information Science (called LEEP. It draws on a framework presented by Mynatt, et al. (1998, which provides a lens for talking about on-line community as a set of affordances. This framework is applied to illustrate the interactions, artefacts, and expectations that shape this community.

  16. On-line range images registration with GPGPU

    Science.gov (United States)

    Będkowski, J.; Naruniec, J.

    2013-03-01

    This paper concerns implementation of algorithms in the two important aspects of modern 3D data processing: data registration and segmentation. Solution proposed for the first topic is based on the 3D space decomposition, while the latter on image processing and local neighbourhood search. Data processing is implemented by using NVIDIA compute unified device architecture (NIVIDIA CUDA) parallel computation. The result of the segmentation is a coloured map where different colours correspond to different objects, such as walls, floor and stairs. The research is related to the problem of collecting 3D data with a RGB-D camera mounted on a rotated head, to be used in mobile robot applications. Performance of the data registration algorithm is aimed for on-line processing. The iterative closest point (ICP) approach is chosen as a registration method. Computations are based on the parallel fast nearest neighbour search. This procedure decomposes 3D space into cubic buckets and, therefore, the time of the matching is deterministic. First technique of the data segmentation uses accele-rometers integrated with a RGB-D sensor to obtain rotation compensation and image processing method for defining pre-requisites of the known categories. The second technique uses the adapted nearest neighbour search procedure for obtaining normal vectors for each range point.

  17. Enhancing communication skills for pediatric visits through on-line training using video demonstrations

    Directory of Open Access Journals (Sweden)

    Wissow Larry

    2008-02-01

    Full Text Available Abstract Background Training in communication skills for health professionals is important, but there are substantial barriers to individual in-person training for practicing clinicians. We evaluated the feasibility and desirability of on-line training and sought suggestions for future courses. Methods Based on successful in-person curricula for communication skills and our previous on-line curricula, we created an on-line course consisting of 28 modules (4.75 hours CME credit about communication skills during pediatric visits that included a mental health concern; each module included a brief case, a multiple choice question, an explanation, and a 1–2 minute video demonstrating key skills. Specific communication skills included: greeting, setting an agenda, discussing diagnosis and treatment, and managing negative interactions. The course was announced by emails in spring, 2007; the course was available on-line for 60 days; we aimed to enroll 50 clinicians. Outcomes were analyzed for those who evaluated the course within 75 days of its initial availability. Results Overall, 61 clinicians registered, of whom most were nurses (N = 24, physicians (N = 22, or psychologists or social workers (N = 12. Of the 36 (59% clinicians who evaluated the course, over 85% agreed that all course objectives had been met; over 90% reported greater confidence in greetings and agenda-setting; and over 80% reported greater confidence in discussing diagnosis and treatment and managing negative interactions. Nearly all, 97% would recommend the course to other clinicians and trainees. Suggestions for improvement included a library of additional video vignettes and written materials to accompany the on-line training. Conclusion On-line training in communication skills for pediatric mental health visits is feasible, desirable and associated with increased confidence in key skills. Positive feedback from clinicians suggests that a comparison of on-line versus in

  18. On-Line Trajectory Retargeting for Alternate Landing Sites Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Barron Associates, Inc. proposes to develop a novel on-line trajectory optimization approach for Reusable Launch Vehicles (RLVs) under failure scenarios, targeting...

  19. First results of the INSIDE in-beam PET scanner for the on-line monitoring of particle therapy treatments

    Science.gov (United States)

    Piliero, M. A.; Belcari, N.; Bisogni, M. G.; Camarlinghi, N.; Cerello, P.; Coli, S.; Del Guerra, A.; Ferrero, V.; Fiorina, E.; Giraudo, G.; Kostara, E.; Morrocchi, M.; Pennazio, F.; Peroni, C.; Pirrone, G.; Rivetti, A.; Rolo, M. D.; Rosso, V.; Sportelli, G.; Wheadon, R.

    2016-12-01

    Quality assessment of particle therapy treatments by means of PET systems has been carried out since late `90 and it is one of the most promising in-vivo non invasive monitoring techniques employed clinically. It can be performed with a diagnostic PET scanners installed outside the treatment room (off-line monitoring) or inside the treatment room (in-room monitoring). However the most efficient way is by integrating a PET scanner with the treatment delivery system (on-line monitoring) so that the biological wash out and the patient repositioning errors are minimized. In this work we present the performance of the in-beam PET scanner developed within the INSIDE project. The INSIDE PET scanner is made of two planar heads, 10 cm wide (transaxially) and 25 cm long (axially), composed of pixellated LFS crystals coupled to Hamamatsu MPPCs. Custom designed Front-End Electronics (FE) and Data AcQuisition (DAQ) systems allow an on-line reconstruction of PET images from separated in-spill and inter-spill data sets. The INSIDE PET scanner has been recently delivered at the CNAO (Pavia, Italy) hadrontherapy facility and the first experimental measurements have been carried out. Homogeneous PMMA phantoms and PMMA phantoms with small air and bone inserts were irradiated with monoenergetic clinical proton beams. The activity range was evaluated at various benchmark positions within the field of view to assess the homogeneity of response of the PET system. Repeated irradiations of PMMA phantoms with clinical spread out Bragg peak proton beams were performed to evaluate the reproducibility of the PET signal. The results found in this work show that the response of the INSIDE PET scanner is independent of the position within the radiation field. Results also show the capability of the INSIDE PET scanner to distinguish variations of the activity range due to small tissue inhomogeneities. Finally, the reproducibility of the activity range measurement was within 1 mm.

  20. ON-LINE SCHEDULING WITH REJECTION ON IDENTICAL PARALLEL MACHINES

    Institute of Scientific and Technical Information of China (English)

    Cuixia MIAO; Yuzhong ZHANG

    2006-01-01

    In this paper, we consider the on-line scheduling of unit time jobs with rejection on m identical parallel machines. The objective is to minimize the total completion time of the accepted jobs plus the total penalty of the rejected jobs. We give an on-line algorithm for the problem with competitive ratio 1/2(2 + √3) ≈ 1.86602.