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Sample records for oligozoospermic infertility patients

  1. Detection of structural and numerical chomosomal abnormalities by ACM-FISH analysis in sperm of oligozoospermic infertility patients

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    Schmid, T E; Brinkworth, M H; Hill, F; Sloter, E; Kamischke, A; Marchetti, F; Nieschlag, E; Wyrobek, A J

    2003-11-10

    Modern reproductive technologies are enabling the treatment of infertile men with severe disturbances of spermatogenesis. The possibility of elevated frequencies of genetically and chromosomally defective sperm has become an issue of concern with the increased usage of intracytoplasmic sperm injection (ICSI), which can enable men with severely impaired sperm production to father children. Several papers have been published about aneuploidy in oligozoospermic patients, but relatively little is known about chromosome structural aberrations in the sperm of these patients. We examined sperm from infertile, oligozoospermic individuals for structural and numerical chromosomal abnormalities using a multicolor ACM FISH assay that utilizes DNA probes specific for three regions of chromosome 1 to detect human sperm that carry numerical chromosomal abnormalities plus two categories of structural aberrations: duplications and deletions of 1pter and 1cen, and chromosomal breaks within the 1cen-1q12 region. There was a significant increase in the average frequencies of sperm with duplications and deletions in the infertility patients compared with the healthy concurrent controls. There was also a significantly elevated level of breaks within the 1cen-1q12 region. There was no evidence for an increase in chromosome-1 disomy, or in diploidy. Our data reveal that oligozoospermia is associated with chromosomal structural abnormalities suggesting that, oligozoospermic men carry a higher burden of transmissible, chromosome damage. The findings raise the possibility of elevated levels of transmissible chromosomal defects following ICSI treatment.

  2. Detection of structural and numerical chromosomal abnormalities by ACM-FISH analysis in sperm of oligozoospermic infertility patients.

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    Schmid, T E; Brinkworth, M H; Hill, F; Sloter, E; Kamischke, A; Marchetti, F; Nieschlag, E; Wyrobek, A J

    2004-06-01

    Modern reproductive technologies are enabling the treatment of infertile men with severe disturbances of spermatogenesis. The possibility of elevated frequencies of genetically and chromosomally defective sperm has become an issue of concern with the increased usage of ICSI, which can enable men with severely impaired sperm production to father children. Several papers have been published reporting aneuploidy in oligozoospermic patients, but relatively little is known about chromosome structural aberrations in the sperm of these patients. We examined sperm from infertile, oligozoospermic individuals for structural and numerical chromosomal abnormalities using a multicolour ACM fluorescence in situ hybridization (FISH) assay that utilizes DNA probes specific for three regions of chromosome 1 to detect human sperm that carry numerical chromosomal abnormalities plus two categories of structural aberrations: duplications and deletions of 1pter and 1cen, and chromosomal breaks within the 1cen-1q12 region. There was a significant increase in the average frequencies of sperm with duplications and deletions in the infertility patients compared with the healthy concurrent controls. There was also a significantly elevated level of breaks within the 1cen-1q12 region. There was no evidence for an increase in chromosome 1 disomy, or in diploidy. Our data reveal that oligozoospermia is associated with chromosomal structural abnormalities, suggesting that oligozoospermic men carry a higher burden of transmissible, chromosome damage. The findings raise the possibility of elevated levels of transmissible chromosomal defects following ICSI treatment.

  3. Serum and semen zinc levels in normozoospermic and oligozoospermic men

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    Madding, C.I.; Jacob, M.; Ramsay, V.P.; Sokol, R.Z.

    1986-01-01

    We studied 11 unselected men who presented to a Reproductive Endocrinology Clinic with histories of infertility and low sperm counts. Reproductive hormones and semen und serum zinc levels were measured. All men had semen analyses performed on at least three separate occasions. A similar set of laboratory evaluations were performed on 11 other men who had normal semen analyses and no history of infertility. No abnormalities of reproductive hormones were found in either group. Mean serum zinc levels were significantly lower in the infertile men. Mean semen zinc levels were not significantly different. There was no correlation between serum and semen zinc levels in either group. A significant correlation was found between sperm count and semen zinc in the volunteers with normal counts, but not in the oligozoospermic men. The results obtained in this study suggest that lowered serum zinc is more common than formerly appreciated in unselected patients with infertility. The high level of zinc found in semen is due primarily to the secretions of the prostate gland and reflects prostatic stores. Serum zinc is thought to be a reasonable indicator of zinc status. The lack of correlation between serum zinc and semen zinc found in our study suggests that mild zinc deficiency may lower serum zinc while the larger prostatic zinc stores remain unaffected.

  4. CAG repeat length in androgen receptor gene and male infertility in Egyptian patients.

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    Mosaad, Y M; Shahin, D; Elkholy, A A-M; Mosbah, A; Badawy, W

    2012-02-01

    The CAG repeat and its association with infertility has been debatable. Therefore, this study was planned to assess the distribution of CAG repeat expansion in Egyptian patients and to investigate its association with male infertility. Forty-five infertile men were eligible for the study in addition to 20 aged-matched fertile males as control. Semen analysis, scrotal sonography, assay of serum testosterone, follicle-stimulating hormone (FSH) and luteinising hormone (LH), and determination of the CAG repeat number within exon 1 of the androgen receptor (AR) gene were carried out. Statistically significant difference was found between infertile and control groups regarding sperm count, sperm motility, serum FSH level and CAG repeats (P CAG repeats (P = 1.0) was found between oligozoospermic and asthenospermic groups; negative correlation was found between CAG repeat length and sperm count, and a positive correlation was found between CAG repeat length and serum FSH (P CAG repeat may be associated with lower AR function with derangement of sperm production, and this may contribute to male infertility in Egyptian men.

  5. [Hysteroscopic evaluation in patients with infertility].

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    Lasmar, Ricardo Bassil; Barrozo, Paulo Roberto Mussel; Parente, Raphael Câmara Medeiros; Lasmar, Bernardo Portugal; da Rosa, Daniela Baltar; Penna, Ivan Araujo; Dias, Rogério

    2010-08-01

    to describe hysteroscopy findings in infertile patients. this was a retrospective series of 953 patients with diagnosis of infertility evaluated by hysteroscopy. A total of 957 patients investigated for infertility were subjected to hysteroscopy, preferentially during the first phase of the menstrual cycle. When necessary, directed biopsies (under direct visualization during the exam) or guided biopsies were obtained using a Novak curette after defining the site to be biopsied during the hysteroscopic examination. Outcome frequencies were determined as percentages, and the χ2 test was used for the correlations. The statistical software EpiInfo 2000 (CDC) was used for data analysis. a normal uterine cavity was detected in 436 cases (45.8%). This was the most frequent diagnosis for women with primary infertility and for women with one or no abortion (pinfertility. Patients with a history of abortion and infertility should be submitted to hysteroscopy in order to rule out intrauterine synechiae as a possible cause of infertility.

  6. Survey of carnitine content of human semen using a semiquantitative auxanographic method: decreased semen total carnitine concentration in patients with azoospermia or severe oligozoospermia.

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    Soffer, Y; Shalev, D P; Weissenberg, R; Orenstein, H; Nebel, L; Lewin, L M

    1981-01-01

    A microbiological method, using the carnitine-requiring yeast, Torulopsis bovina ATCC 26014, was developed to identify samples of human semen which contained low levels (less than 250 micron M) of total carnitine. Of 399 semen samples from a male infertility clinic which were tested, 30 (7.5%) were low in carnitine. Of these, 14 were azoospermic and 16 were severely oligozoospermic. Some azoospermic samples (19 = 58%) and severely oligozoospermic samples (51 = 79%) did not give evidence of low carnitine concentrations. These results indicate that decreased total carnitine concentration in semen occurs in certain classes of azoospermic and severely oligozoospermic patients.

  7. Evaluating Infertility

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    ... Education & Events Advocacy For Patients About ACOG Evaluating Infertility Home For Patients Search FAQs Evaluating Infertility Page ... Evaluating Infertility FAQ136, June 2012 PDF Format Evaluating Infertility Gynecologic Problems What is an infertility evaluation? When ...

  8. Treating Infertility

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    ... Education & Events Advocacy For Patients About ACOG Treating Infertility Home For Patients Search FAQs Treating Infertility Page ... Treating Infertility FAQ137, March 2015 PDF Format Treating Infertility Gynecologic Problems What is infertility? What treatment options ...

  9. Evaluating Infertility

    Science.gov (United States)

    ... Education & Events Advocacy For Patients About ACOG Evaluating Infertility Home For Patients Search FAQs Evaluating Infertility Page ... Evaluating Infertility FAQ136, June 2012 PDF Format Evaluating Infertility Gynecologic Problems What is an infertility evaluation? When ...

  10. Infertility

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    ... MALE INFERTILITY Male infertility may be due to: Decreased number of sperm Blockage that prevents the sperm ... from woman to woman. Infertility problems and miscarriage rates increase ... a successful pregnancy if childbearing is delayed until after age 35. ...

  11. Infertility

    Science.gov (United States)

    Infertility means not being able to become pregnant after a year of trying. If a woman can ... keeps having miscarriages or stillbirths, that's also called infertility. Infertility is fairly common. After one year of ...

  12. [CHROMOSOMAL ABNORMALITIES IN PATIENTS WITH INFERTILITY].

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    Pylyp, L Y; Spinenko, L O; Verhoglyad, N V; Kashevarova, O O; Zukin, V D

    2015-01-01

    To assess the frequency and structure of chromosomal abnormalities in patients with infertility, a retrospective analysis of cytogenetic studies of 3414 patients (1741 females and 1673 males), referred to the Clinic of reproductive medicine "Nadiya" from 2007 to 2012, was performed. Chromosomal abnormalities were detected in 2.37% patients: 2.79% in males and 1.95% in females. Balanced structural chromosomal abnormalities prevailed over numerical abnormalities and corresponded to 80.2% of all chromosomal abnormalities detected in the studied group. Sex chromosome abnormalities made up 23.5% of chromosomal pathology (19/81) and included gonosomal aneuploidies in 84% of cases (16/19) and structural abnormalities of chromosome Y in 16% of cases (3/19). The low level sex chromosome mosaicism was detected with the frequency of 0.55%. Our results highlight the importance of cytogenetic studies in patients seeking infertility treatment by assisted reproductive technologies, since an abnormal finding not only provide a firm diagnosis to couples with infertility, but also influences significantly the approach to infertility treatment in such patients.

  13. Prevalence of Infertility Problems among Iranian Infertile Patients Referred to Royan Institute

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    Mahdi Sepidarkish

    2016-09-01

    Full Text Available Background: Few studies have been conducted on the infertility problems in Iran. This study aimed to investigate the prevalence of infertility problems and related factors in Iranian infertile patients. Materials and Methods: In this cross sectional study, 405 infertile patients referred to Royan Institute, Tehran, Iran, between 2014 and 2015, were selected by simple random sampling. Participants completed the Fertility Problem Inventory (FPI including 46 questions in five domains (social concern, sexual concern, relationship concern, rejection of parenthood, and need for parenthood. Mean difference between male and female was verified using independent-samples Student’s t test. A generalized linear model (GLM was also used for testing the effect of variables on the fertility problems. Data was analyzed using Stata software version 13. Results: The mean age (SD of participants was 31.28 (5.42. Our results showed that 160 infertile men (95.23% were classified as very high prevalence of infertility problems. Among infertile women, 83 patients (35.02% were as very high prevalence of infertility problems, and 154 patients (64.98% were as high prevalence. Age (P<0.001, sex (P<0.001, a history of abortion (P=0.009, failure of previous treatment (P<0.001, and education (P=0.014 had a significant relationship with FPI scores. Conclusion: Bases on the results of current study, an younger male with lower education level, history of abortion and history of previous treatments failure experienced more infertility problems.

  14. Associations of Y-chromosome subdeletion gr/gr with the prevalence of Y-chromosome haplogroups in infertile patients.

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    Shahid, Mohammad; Dhillon, Varinderpal S; Khalil, Hesham Saleh; Sexana, Anubha; Husain, Syed Akhtar

    2011-01-01

    Microdeletions in azoospermia factor (AZF) region on distal Yq are associated with male infertility and spermatogenic failure due to intra-chromosomal homologous recombination between large nearly identical repeat amplicons and are found in ∼10% of azoospermic and severe oligozoospermic cases. Although AZFc is deleted in azoospermia or oligozoospermia, no definitive conclusion has been drawn for the role of partial AZFc deletions to spermatogenic failure. Therefore, this study is planned to investigate the role of gr/gr subdeletions in individuals with spermatogenic failure and to find its relationship with Y chromosome haplogroups (HGs) in infertile men from Indian population. It is a case-control study involving 236 azoospermic, 182 oligospermic and 240 healthy normozoospermic men. We found 18 gr/gr, 11 b1/b3 and 2 b2/b3 subdeletions in azoospermic patients and 12 gr/gr, 5 b1/b3 and 4 b2/b3 subdeletions in oligospermic patients. However, we also found seven gr/gr deletions in normozoospermic men. Seven patients each with spermatogenic arrest and oligospermia who carry gr/gr subdeletions have deleted DAZ3/DAZ4 genes. A total of 11 patients with sertoli cell-only syndrome (SCOS) and 5 oligospermic patients with gr/gr subdeletions also have DAZ1/DAZ2 genes deleted indicating that deletions of DAZ genes contributed differently to damage to spermatogenic process. L1 HG is found in patients showing b1/b3 subdeletions, whereas HG H1a2 and H1b were found in normozoospermic individuals with gr/gr subdeletions. Our results provide evidence of association between the occurrence of subdeletions and male infertility as well as the severity of the spermatogenic failure.

  15. SURGICAL TREATMENT OF ENDOMETRIOSIS IN INFERTILE PATIENTS

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    Andrej Vogler

    2003-12-01

    Full Text Available Background. Endometriosis is nowadays probably the most frequent cause of infertility or subfertility and is revealed in approximately 30–40% of infertile women. The association between fertility and minimal or mild endometriosis remains unclear and controversial. Moderate and severe forms of the disease distort anatomical relations in the minor pelvis, resulting in infertility. The goals of endometriosis treatment are relief of pain symptoms, prevention of the disease progression and fertility improvement. Treatment of stages I and II endometriosis (according to the R-AFS classification may be expectative, medical or surgical. In severely forms of the disease (stage III and IV the method of choice is surgical treatment. Combined medical and surgical treatment is justified only in cases, in which the complete endometriotic tissue removal is not possible or recurrence of pain symptoms occur. Nowadays, laparoscopic surgical treatment is the golden standard being the diagnostic and therapeutic tool during the same procedure. The aim of this study was to evaluate the fertility rate after surgical treatment of different stages of endometriosis.Patients and methods. In prospectively designed study 100 infertile women were included. The only known cause of infertility was endometriosis. In group A there were 51 patients with stage I and II endometriosis, whereas in group B there were 49 patients with stage III and IV of the disease. Endometriosis was diagnosed and treated laparoscopically. Endometriotic implants were removed either with bipolar coagulation or CO2 laser vaporisation, whereas adhesions were sharp or blunt dissected, and endometriomas stripped out of ovaries. Pregnancy rates were calculated for both groups of patients, and statistically compared between the groups.Results. Mean age of patients was 29.25 (SD ± 4.08 years and did not significantly differ between the groups of patients (29.5 years in group A and 29 years in group B. In

  16. Chromosomal abnormalities and y chromosome microdeletions in infertile men with varicocele and idiopathic infertility of South Indian origin.

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    Rao, Lakshmi; Babu, Arvind; Kanakavalli, Murthy; Padmalatha, Venkata; Singh, Amarpal; Singh, Prashant Kumar; Deenadayal, Mamata; Singh, Lalji

    2004-01-01

    Various factors cause spermatogenesis arrest in men and, in a large number of cases, the underlying reason still remains unknown. Little attention is paid to determining the genetic defects of varicocele-related infertility. The objective of our present study was to investigate the chromosomal abnormalities and Y chromosome microdeletions in infertile men of South Indian origin with varicocele and idiopathic infertility. Metaphase chromosomes of 251 infertile men with varicocele and unexplained infertility were analyzed using Giemsa-Trypsin-Giemsa (GTG) banding and fluorescence in situ hybridization (FISH). The microdeletions in 6 genes and 18 sequence-tagged-sites (STS) in the Yq region were screened using polymerase chain reaction (PCR) techniques. Out of 251 infertile men, 57 (22.7%) men were with varicocele, of which 8.77% were azoospermic, 26.31% were severely oligozoospermic, 21.05% were mildly oligozoospermic, and 43.85% were oligoasthenoteratozoospermic (OAT), and 194 (77.29%), with idiopathic infertility, of which 51% were azoospermic, 13.40% were severely oligozoospermic, 19.07% were mildly oligozoospermic, and 16.4% were with OAT. Genetic defects were observed in 38 (15.13%) infertile individuals, including 14 (24.56%) men with varicocele and 24 (12.37%) men with idiopathic infertility. The frequencies of chromosomal defects in varicocele and idiopathic infertility were 19.3% and 8.76%, respectively, whereas Y chromosome microdeletions were 5.26% and 3.60%, respectively. Overall rate of incidence of chromosomal anomalies and microdeletions in 251 infertile men were 11.5% and 3.98%, respectively, indicating a very significant higher association of genetic defects with varicocele than idiopathic male infertility. Our data also demonstrate that, among infertile men with varicocele, severely oligozoospermic and OAT men with varicocele have higher incidences of genetic defects than mildly oligozoospermic and azoospermic men.

  17. Infertility.

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    Jose-Miller, Alaina B; Boyden, Jennifer W; Frey, Keith A

    2007-03-15

    Infertility is defined as failure to achieve pregnancy during one year of frequent, unprotected intercourse. Evaluation generally begins after 12 months, but it can be initiated earlier if infertility is suspected based on history or if the female partner is older than 35 years. Major causes of infertility include male factors, ovarian dysfunction, tubal disease, endometriosis, and uterine or cervical factors. A careful history and physical examination of each partner can suggest a single or multifactorial etiology and can direct further investigation. Ovulation can be documented with a home urinary luteinizing hormone kit. Hysterosalpingography and pelvic ultrasonography can be used to screen for uterine and fallopian tube disease. Hysteroscopy and/or laparoscopy can be used if no abnormalities are found on initial screening. Women older than 35 years also may benefit from ovarian reserve testing of follicle-stimulating hormone and estradiol levels on day 3 of the menstrual cycle, the clomiphene citrate challenge test, or pelvic ultrasonography for antral follicle count to determine treatment options and the likelihood of success. Options for the treatment of male factor infertility include gonadotropin therapy, intrauterine insemination, or in vitro fertilization. Infertility attributed to ovulatory dysfunction often can be treated with oral ovulation-inducing agents in a primary care setting. Women with poor ovarian reserve have more success with oocyte donation. In certain cases, tubal disease may be treatable by surgical repair or by in vitro fertilization. Infertility attributed to endometriosis may be amenable to surgery, induction of ovulation with intrauterine insemination, or in vitro fertilization. Unexplained infertility may be managed with ovulation induction, intrauterine insemination, or both. The overall likelihood of successful pregnancy with treatment is nearly 50 percent.

  18. [Genetic variants associated to male infertility in Mexican patients].

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    Piña-Aguilar, Raúl Eduardo; Chima-Galán, María del Carmen; Yerena-de-vega, María de la Concepción A; Regalado-Hernández, Miguel Angel; Sánchez-Guerrero, Cecilia; García-Ortiz, Liliana; Santillán-Hernández, Yuritzi; Moreno-García, Jesús Daniel

    2013-05-01

    Recently Mexican Federation of Obstetrics and Gynecology Colleges (Federación Mexicana de Colegios de Obstetricia y Ginecologia, FEMECOG) published the Mexican guideline forthe management of male infertility, which suggests performing genetic laboratory tests as part of diagnosis and management of infertile patients and states that these should receive genetic counseling. This paper reviews the genetic approach proposed by Mexican guideline. A systematic review of medical literature was performed in Pubmed and Web of Knowledge from 1980 to 2012 in order to find reports of genetic variants associated to male infertility in Mexican patients. Also it is discussed the current knowledge of these variants, their clinical implications and finally the guidelines and recommendations for their molecular diagnosis. Most genetic variants in Mexican infertile patients are chromosome abnormalities. In relation to other variants there is only a report of Y chromosome microdeletions, repeated CAG in androgen receptor and more common mutations in CFTR, and other article reporting mutations in CFTR in patients with congenital absence of vas deferens. Little is known about the genetics of Mexican infertile patients apart from chromosome abnormalities. However, the contribution of genetics as etiology of male infertility is taking more relevance and currently the consensual management of infertile male should include the screening of genetic background. This review pretends to be a quick guide for clinicians who want to know about reports of genetic variants related to male infertility in Mexican population and how to approach their diagnosis.

  19. Serum inhibin B values in infertile patients

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    Z. A. Kadyrov

    2016-01-01

    Full Text Available The increased interest in inhibin B generated by Sertoli cells is due to the fact that on the basis of findings, some authors recorded a relationship between the level of this hormone and infertility. The paper gives the results of an investigation of male sex hormones (inhibin B, follicle-stimulating and anti-Müllerian hormones in the serum of patients with azoospermia (Group 1, who had spermatogenesis, as evidenced by testicular biopsy, who had no spermatogenesis (Group 2, and who had oligoasthenozoospermia (Group 3. The investigation indicated that Group 1 had a normal inhibin B level that was more than twice lower in Group 2. In addition, the latter group was recorded to have elevated follicle-stimulating hormone levels and low anti-Müllerian hormone concentrations as compared to Group 1.

  20. Hormonal and seminal parameters in infertile men.

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    Bruno, B; Francavilla, S; Properzi, G; Martini, M; Fabbrini, A

    1986-01-01

    500 infertile patients (250 with and 250 without left side varicocele) and 33 fertile men were evaluated as far as seminal parameters and the hormonal status were concerned. Sperm motility was constantly lower in infertile patients also when infertile group was compared to fertile one with the same sperm density. Serum testosterone levels were lower in infertile groups when compared to fertile men, and this confirms the existence of an androgenic deficit as a common finding in infertility associated or not to varicocele. FSH and LH increased (p less than 0.001) when sperm density dropped to less than 5 X 10(6) spermatozoa/ml. A negative correlation was found between both gonadotropins and sperm count (p less than 0.001), also after exclusion of azoo- and oligozoospermic (less than 5 X 10(6) spermatozoa/ml) patients (p less than 0.01). Gonadotropins were moreover tightly correlated between each other (p less than 0.001). Our data suggest that both gonadotropins are tightly tuned with sperm output and thus with the spermatogenic potential.

  1. Infertility Patients' Mental Health Problems Often Unaddressed

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    ... therapy on top of that. To Pasch, the solution is for clinics to have a mental health ... Services, or federal policy. More Health News on: Depression Infertility Recent Health News Related MedlinePlus Health Topics ...

  2. Hysteroscopic evaluation in infertile patients: a prospective study

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    Latika Sahu

    2012-12-01

    Full Text Available Background: Hysteroscopy is the gold standard procedure for uterine cavity exploration. However, hysteroscopy is only recommended by the WHO when clinical or complementary exams (ultrasound, HSG suggest intrauterine abnormality or after in vitro fertilization failure. Nevertheless, many specialists feel that hysteroscopy is a more accurate tool. The aim of this prospective study is to assess the value of diagnostic hysteroscopy in a primary workup of infertility by describing hysteroscopy findings in a population of 324 infertile patients during 18 months (December 2010 - May 2012. Methods: We analysed prospectively 324 infertile patients in gynaecology OT setting. Diagnostic video-assisted hysteroscopy was performed using a flexible hysteroscope. Hysteroscopy was performed with a standard sequence, inspecting the endocervical canal, uterine cavity, endometrium, and tubal ostia and findings recorded. Results: Hysteroscopy was normal in 65.12% of patients. Cervico-isthmic abnormalities were present in 6.48% of patients with cervical stenosis being the major abnormality. Uterine cavity was normal in 86% of patients. Observed abnormalities were septate uterus in 10 cases, intrauterine synechiae in 16 cases, sub mucus myoma in 2 cases, deformed cavity in 10 cases and endometrial polyp in 2 cases. Ostial fibrosis was observed in 29 patients. Endometrial abnormalities (fibrosis, inflammation were observed in 30 patients. Seven patients turned out to be of genital tuberculosis with endometrial biopsy. No significance was found regarding the total number of intrauterine pathologies when comparing the groups of primary versus secondary infertility. Conclusions: Rates of abnormal findings in infertile patient who underwent diagnostic hysteroscopy was 34.88% in our study. Our data are an additional argument to suggest hysteroscopy as part of investigation in infertile woman. Routine diagnostic hysteroscopy should be part of an infertility workup in primary

  3. Laparascopic ventrosuspension in infertile patients. A new technique.

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    Serour, G I; Hefnawi, F

    1981-01-01

    This paper describes the application of the Falope-Ring via laparascopy to the round ligaments in 86 infertile patients, for correction of retroversion of the uterus. Diagnostic laparascopy was performed on 2600 cases of infertility at Al-Azhar University Teaching Hospitals during a 3-year period. Laparascopy was performed as a primary mehtod of investigation of infertility, after clinical examination and semen analysis in 866 patients. These included long term cases of infertility, late marriage and cases where pelvic pathology was suspected on clinical grounds. Laparascopy was used as a final line of investigation of infertility in 1734 patients. In 86 patients with retroverted uterus as the only abnormality deteched, ventrosuspension was performed via the laparascope, by applying Falope-Rings to the round ligaments. These patients were followed up for periods varying from 6 months to 2 years. Pregnancy occurred in 24 patients and improvement of backache, deep dysparunea, congestive dysmenorrhea and leukorrhea occurred in 88.37%, 83.72%, 72.05% and 68.76%, respectively. The technique described in this paper is simple, easy to learn, can be performed under general or local anesthesia and is performed during the laparascopic investigation of the infertile cases and thus does not add an extra risk of operation or cost to the patient.

  4. Prevalence of Antichlamydia Antibody Status in Infertile Patients

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    Batool Rashidi

    2007-01-01

    Full Text Available Background: The goal of the study was to evaluate the prevalence of antichlamydia antibody indifferent subgroups of infertile women.Material and Methods: The study was performed on 300 women admitted to a university-basedclinic.The antichlamydia antibody was assayed via ELISA method.Results: Positive titer was reported in 32.3 percent of the population under study. Statisticallysignificant differences between positive and negative titres were noted in groups with tubal infertility (p;0.006 patients with history of PID (p: 0.003 and vaginitis (P: 0.001 and patients with tubal pathologyreported on hysterosalpingography (P: 0.027.Conclusion: According to the results of the study, it seems that there is a strong correlation betweenChlamydia trachomatis infection and tubal infertility in Iranian infertile patients.

  5. Cytogenetic of Male Infertility

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    Lutfiye Ozpak

    2011-08-01

    Full Text Available Infertility by definition, is not to get pregnant within one year of regular sexual relationship without protection, affects 15-20% of reproductive age couples. Approximately 30% of infertility cases are male originated. Male infertility is caused by endocrine-related genetic defects affecting urogenital system function. These defects adversely affect subsequent spermatogenesis, sexual function, fertility, early embryonic stage of sexual maturation. Autosomal and gonosomal, numerical and structural chromosome abnormalities and related syndromes rank at the top causes of male infertility. Similar chromosome abnormalities are detected in male infertility and as the rate of these abnormalities increase, it was found to reduce sperm count especially in azospermic and oligozoospermic men. [Archives Medical Review Journal 2011; 20(4.000: 230-245

  6. Management of male neurologic patients with infertility

    DEFF Research Database (Denmark)

    Fode, Mikkel; Sønksen, Jens

    2015-01-01

    Many aspects of fertility rely on intact neurologic function and thus neurologic diseases can result in infertility. While research into general female fertility and alterations in male semen quality is limited, we have an abundance of knowledge regarding ejaculatory dysfunction following nerve...

  7. Chromosomal abnormalities and Y chromosome microdeletions in infertile men from Morocco.

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    Naasse, Yassine; Charoute, Hicham; El Houate, Brahim; Elbekkay, Chadli; Razoki, Lunda; Malki, Abderrahim; Barakat, Abdelhamid; Rouba, Hassan

    2015-09-18

    Male infertility is responsible for 50% of infertile couples. Thirty percent of male infertility is due to cytogenetic and genetic abnormalities. In Arab and North African populations, several studies have shown the association of these chromosomal abnormalities with male infertility. Our objective is to evaluate the frequency of chromosomal abnormalities and Y chromosome microdeletions in infertile men from Morocco. A total of 573 Moroccan infertile men (444 azoospermic and 129 oligozoospermic men) referred for cytogenetic analysis to the Department of Cytogenetics of the Pasteur Institute of Morocco, were screened for the presence of chromosomal abnormalities and Y chromosome microdeletions. Chromosomal abnormalities accounted for approximately 10.5% (60/573). Fifty six cases among them have sex chromosome abnormalities (93.34%), including Klinefelter's syndrome in 41 patients (68.34%). Autosomal chromosome abnormalities (6.66%) were observed in 4 patients. Chromosomal abnormalities were more prevalent in azoospermic men (13.06%) than in oligospermic men (1.55%). Y microdeletions were detected in 16 of 85 patients (AZFc: 14.12%, AZFbc: 4.70%), most of them where azoospermic men with no chromosomal abnormality. These results highlighted the need for efficient molecular genetic testing in male infertility diagnosis. In addition, a genetic screening should be performed in infertile men before starting assisted reproductive treatments.

  8. An epidemiologic survey on the causes of infertility in patients referred to infertility center in Fatemieh Hospital in Hamadan

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    Seyedeh Zahra Masoumi

    2015-08-01

    Full Text Available Background: Infertility is considered as a major health care problem of different communities. The high prevalence of this issue doubled its importance. A significant proportion of infertility have been related to environmental conditions and also acquired risk factors. Different environmental conditions emphasized the need to study the different causes of infertility in each area. Objective: The aim of this study was to determine the frequency causes of infertility in infertile couples. Materials and Methods: In this cross sectional descriptive study 1200 infertile men and women that were referred to infertility clinic of Fatemieh Hospital during 2010 to 2011, were examined. This center is the only governmental center for infertility in Hamadan. Sampling was based on census method. Information about the patients was obtained from medical examinations and laboratory findings. To analyze the data, descriptive statistics such as frequencies and the mean were used. Results: The prevalence of primary and secondary infertility was 69.5% and 30.5% respectively. Among the various causes of infertility women factors (88.6% had the highest regard. In the causes of female infertility, menstrual disorders, diseases (obesity, thyroid diseases, and diabetes, ovulation dysfunction, uterine factor, fallopian tubes and cervical factor had the highest prevalence respectively. The causes of male infertility based on their frequency included semen fluid abnormalities, genetic factors, vascular abnormalities, and anti-spermatogenesis factors, respectively. Conclusion: Etiology pattern of infertility in our study is similar with the many other patterns that have been reported by the World Health Organization. However, frequency of menstrual disorders is much higher than other studies that require further consideration.

  9. Chromosomal Abnormalities in Iranian Infertile Males who are Candidates for Assisted Reproductive Techniques

    Directory of Open Access Journals (Sweden)

    Iman Salahshourifar

    2007-01-01

    Full Text Available Background: The present study offers our contribution on the topic by a retrospective analysis of the prevalence of chromosomal abnormalities in a population of Iranian infertile men attending assisted reproduction programs.Materials and Methods: Cytogenetic analysis was performed according to standard methods on cultured cells obtained from the patient peripheral blood. In all, 874 files belonging to male partner of each couple were classified as follows: azoospermic, oligozoospermic and patients with low sperm quality in respect of morphology and motility.Results: Chromosomal abnormalities were observed in 136(15.5% individuals of the whole population studied including 12.0 %, 1.2 % and 2.0% of azoospermic, oligozoospermic and patients with low sperm quality, respectively. Of those, 116 (13.2% had sex chromosome abnormalities and 20(2.3% had autosomal chromosome abnormalities.Conclusion: We observed high frequency of aneuploidy and sex chromosomal mosaicism in azoospermic men and high structural aberrations in males with low sperm quality. We suggested that type of chromosomal abnormalities had an inverse relation to sperm count. So that, high chromosomal aneuploidy was detected in males with lower sperm count and high structural aberration was detected in males with low sperm quality. Chromosomal abnormalities are a major cause of male infertility. Consequently, Genetic testing and counselling is indicated for infertile men with abnormal semen parameters with either abnormal karyotype or normal karyotype before applying assisted reproductive techniques.

  10. Relationship between testicular volume and testicular function: comparison of the Prader orchidometric and ultrasonographic measurements in patients with infertility

    Institute of Scientific and Technical Information of China (English)

    Hideo Sakamoto; Yoshio Ogawa; Hideki Yoshida

    2008-01-01

    Aim: To evaluate the relationship between testicular function and testicular volume measured by using Prader orchidometry and ultrasonography (US) to determine the critical testicular volume indicating normal testicular func-tion by each method. Methods: Total testicular volume (right plus left testicular volume) was measured in 794 testes in 397 men with infertility (mean age, 35.6 years) using a Prader orchidometer and also by ultrasonography.Ultrasonographic testicular volumes were calculated as length×width×height×0.71. To evaluate volume-function relationships, patients were divided into 10 groups representing 5-mL increments of total testicular volume by each method from below 10 mL to 50 mL or more. Results: Mean total testicular volume based on Prader orchidometry and US were 36.8 mL and 26.3 mL, respectively. Semen volume, sperm density, total sperm count, total motile sperm count, and serum FSH, LH, and testosterone all correlated significantly with total testicular volume measured by either method. Mean sperm density was in the oligozoospermic range in patients with total testicular volume below 35 mL by orchidometry or below 20 mL by ultrasonography. Mean total sperm count was subnormal in patients with total testicular volume below 30 mL by orchidometry or under 20 mL by ultrasonography. Conclusion: Testicular volume measured by either ultrasonography or Prader orchidometry correlated significantly with testicular function.However, critical total testicular volume indicating normal or nearly normal testicular function was 30 mL to 35 mL using Prader orchidometer and 20 mL using ultrasonography. Prader orchidometry morphometrically and function-ally overestimated the testicular volume in comparison to US.

  11. Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts

    Science.gov (United States)

    Punab, M.; Poolamets, O.; Paju, P.; Vihljajev, V.; Pomm, K.; Ladva, R.; Korrovits, P.; Laan, M.

    2017-01-01

    severe forms of impaired spermatogenesis were relatively well understood; causes were assigned: for aspermia in 46/46 cases (100%), for azoospermia in 321/388 cases (82.7%), and for cryptozoospermia in 54/130 cases (41.5%). In contrast, 75% of oligozoospermia cases remained unexplained. The main cause of aspermia was severe sexual dysfunction (71.7% of aspermia patients). Azoospermia patients accounted for 86.4% of all cases diagnosed with secondary hypogonadism and 97.1% of patients with seminal tract obstruction. Of patients with a known genetic factor, 87.4% had extreme infertility (azoo-, crypto- or aspermia). The prevalence of congenital anomalies in the uro-genital tract was not clearly correlated with the severity of impaired sperm production. Previously defined ‘potential contributing factors’ varicocele and leukocytospermia were excluded as the primary causes of male infertility. However, their incidence was >2-fold higher (31.0 vs 13.5% and 16.1 vs 7.4%; P < 0.001) in the idiopathic infertility group compared to controls. In addition, the proportions of overweight (or obese) patients and patients suffering from a chronic disease were significantly increased in almost all of the patient subgroups. LIMITATIONS REASONS FOR CAUTION The study included only subjects with reduced total spermatozoa counts. Thus, these findings cannot be automatically applied to all male factor infertility cases. WIDER IMPLICATIONS OF THE FINDINGS The novel insights and improved clarity achieved in the comprehensive analysis regarding the absolute, causative and plausible factors behind male infertility, as well as the ‘potential contributing factors’, will be valuable tools in updating the current clinical guidelines. The study highlights knowledge gaps and reiterates an urgent need to uncover the causes and mechanisms behind, and potential treatments of, oligozoospermic cases, representing the majority of idiopathic infertility patients (86.3%). STUDY FUNDING

  12. Male infertility in China: laboratory finding for AZF microdeletions and chromosomal abnormalities in infertile men from Northeastern China.

    Science.gov (United States)

    Wang, Rui-Xue; Fu, Chao; Yang, Ya-Ping; Han, Rong-Rong; Dong, Yuan; Dai, Ru-Lin; Liu, Rui-Zhi

    2010-07-01

    To investigate the frequencies of AZF microdeletions and chromosomal abnormalities in infertile men from Northeastern China. Moreover, to compare the prevalence of these abnormalities with other countries and regions in the world. 305 infertile men were enrolled. A complete semen analysis and reproductive hormones were measured according to standard methods. Multiplex polymerase chain reaction (PCR) amplification using nine specific sequence-tagged sites (STS) were used to detect AZF microdeletions. Karyotype analyses were performed on peripheral blood lymphocytes with standard G-banding. Of the 305 infertile men, 28 (9.2%) had AZF microdeletions and 26 (8.5%) had chromosomal abnormalities. The most frequent microdeletions were in the AZFc+d, followed by AZFc, AZFb+c+d and AZFa. A total of 19 patients (82.6%) had Klinefelter's syndrome (47, XXY) in the azoospermic group. The freqencies of AZF microdeletions and chromosomal abnormalities in infertile men from Northeastern China were comparable with infertile men from other countries and regions. However, there was a slightly higher prevalence rate of AZF microdeletions in oligozoospermic patients than reported in previous studies.

  13. Aneuploidies level in sperm nuclei in patients with infertility.

    Science.gov (United States)

    Alchinbayev, Mirzakarim Karimovich; Aralbayeva, Araylyim Nugmanovna; Tuleyeva, Lazzat Namatullaevna; Duysenbayeva, Svetlana Melsovna; Makazhanov, Marat Abzalovich

    2016-09-01

    Male infertility is a relevant social and medical problem. Male infertility is mostly caused by genetic disorders. The purpose of the study was to analyze the correlation of chromosome aberrations, as well as DNA fragmentation and various manifestations of spermatogenesis disorder. Sperm samples of 58 males with infertility and 23 conditionally healthy males were studied. All patients diagnosed with asthenozoospermia, teratozoospermia, oligoasthenozoospermia and oligoteratozoospermia underwent subsequent analysis of sperm DNA fragmentation. Sperm DNA fragmentation was examined with sperm chromatin dispersion test (sperm chromatin dispersion, Spermprocessor, India) with an Axioscope 40 fluorescent microscope. Fluorescence in situ hybridization with fluorescent probes (Vysis Multi Vysion PGT, Abbot Molecular) was used to study chromosome abnormalities in sperm nuclei with regard to X and Y chromosomes, as well as to chromosomes 18 and 21. It was found that the development of pathospermia was characterized by genetic discontinuity, which manifests as DNA fragmentation and disjunction of chromosomes in meiosis with spermatogenesis. It was also found that the prevailing type of pathospermia in men with infertility was oligozoospermia. In addition, this group also had the highest rate of numerical chromosome abnormalities. This was caused by the degeneration of spermatozoids with aneuploidies in chromosomes. © The Author 2016. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  14. Seminal plasma calcium in normal and infertile patients.

    Science.gov (United States)

    Skandhan, Kalanghot P; Mazumdar, Birendranath; Sumangala, Balakrishnan; Jaya, Vasudevan

    2017-02-03

    In this study an attempt is made to find out the level of calcium in seminal plasma of normal and infertile patients. Semen samples are collected from 34 normal men and 112 infertile patients. After semen evaluation seminal plasma was separated and calcium level was measured in it. Calcium level in mg% is recorded in each group as follows; in normozospermia (n34) 20.14 ± 1.25 (±SE), oligozoospermia (n26) 9.76 ± 1.17, azoospermia (n33) 14.65 ± 2.63, oligoasthenozoosperma (n28) 20.91 ± 1.94 and in asthenozoospermia (n25) 11.56 ± 1.68. Statistically highly significant reduction in calcium is seen in Oligozoospermia and asthenozoospermia. The probable reasons for these two conditions are discussed.

  15. Genetic screening for chromosomal abnormalities and Y chromosome microdeletions in Chinese infertile men.

    Science.gov (United States)

    Fu, Li; Xiong, Da-Ke; Ding, Xian-Ping; Li, Chuang; Zhang, Li-Yuan; Ding, Min; Nie, Shuang-Shuang; Quan, Qiang

    2012-06-01

    To investigate the frequency and type of both chromosomal abnormalities and Y chromosome microdeletions and analyze their association with defective spermatogenesis in Chinese infertile men. This is a single center study. Karyotyping using G-banding and screening for Y chromosome microdeletion by multiplex polymerase chain reaction(PCR)were performed in 200 controls and 1,333 infertile men, including 945 patients with non-obstructive azoospermia and 388 patients with severe oligozoospermia. Out of 1,333 infertile patients, 154(11.55%) presented chromosomal abnormalities. Of these, 139 of 945 (14.71%) were from the azoospermic and 15 of 388 (3.87%) from the severe oligozoospermic patient groups. The incidence of sex chromosomal abnormalities in men with azoospermia was 11.53% compared with 1.03% in men with severe oligozoospermia (P chromosome microdeletions. The incidence of azoospermia factor(AZF) microdeletion was 11.75% and 8.51% in patients with azoospermia and severe oligozoospermia respectively. Deletion of AZFc was the most common and deletions in AZFa or AZFab or AZFabc were found in azoospermic men. In addition, 34 patients had chromosomal abnormalities among the 144 patients with Y chromosome microdeletions. No chromosomal abnormality and microdeletion in AZF region were detected in controls. There was a high incidence (19.80%) of chromosomal abnormalities and Y chromosomal microdeletions in Chinese infertile males with azoospermia or severe oligozoospermia. These findings strongly suggest that genetic screening should be advised to infertile men before starting assisted reproductive treatments.

  16. EFFECT OF ELECTROACUPUNCTURE ON ANTISPERM ANTIBODIES IN MALE INFERTILITY PATIENTS

    Institute of Scientific and Technical Information of China (English)

    伦新; 荣莉

    2003-01-01

    Aims: To explore the therapeutic effect of electroacupuncture (EA) for treatment of male immune-infertility patients and to observe the effect of EA on antisperm antibody (AsAb) positive reaction. Methods: A total of 100 male infertility AsAb-positive patients were randomized into EA group (n = 50, BL- 15, BL- 17, -18, -23, etc. ) and medication group (n=50, oral administration of prednisone, 5 mg/time, t. i. d. ). Serum and sperm AsAb were determined with enzyme immunoassay technique. Results: Following 4 months' treatment, the cure rates and the total effective rates of EA and medication groups were 40.4% (20 cases/50 cases) and 92.0% (45/50), 10.0% (5/50) and 64.0% (32/50) respectively. The cure rate of EA group was significantly superior to that of medication group (P<0.01). But, no significant difference was found between two groups in the total effective rate (P >0.05). After treatment, AsAb positive rates of both groups particularly that of EA group decreased significantly compared with pre-treatment of each group (P<0.05-0.01). Conclusion: EA treatment can work well in the treatment of some immune-mediated male infertility patients and possesses a favorable regulation action on AsAb reaction.

  17. Retained Fetal Bone in Infertile Patients: Two Case Reports

    Directory of Open Access Journals (Sweden)

    Ensieh ShahrokhTehraninejad

    2009-01-01

    Full Text Available The prolonged retention of fetal bone structure is an uncommon condition after a previous abortion.We describe two cases with fetal bone fragment amongst 3589 hysteroscopies (0.05%, who hadno complaint other than secondary infertility. In both patients, hyperechogenic areas were foundthrough transvaginal ultrasound and the bones were removed by hysteroscopy. Despite meticulousevaluation during hysteroscopy, some bones were not observed and were stable during the nextsonography. According to the formation of fetal bones after 11 weeks of pregnancy; patientswith secondary infertility who have a history of abortion that progressed beyond this time andendometrial hyperechoic areas by transvaginal ultrasound should be evaluated for any retainedfetal bone. Hysteroscopy should be performed under abdominal ultrasonography guide to ensurefetal bone tissue is entirely removed during a single surgery.

  18. Treatment strategies for the infertile polycystic ovary syndrome patient.

    Science.gov (United States)

    Tannus, Samer; Burke, Yechiel Z; Kol, Shahar

    2015-11-01

    Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Infertility is a prevalent presenting feature of PCOS, and approximately 75% of these women suffer infertility due to anovulation. Lifestyle modification is considered the first-line treatment and is associated with improved endocrine profile. Clomiphene citrate (CC) should be considered as the first line pharmacologic therapy for ovulation induction. In women who are CC resistant, second-line treatment should be considered, as adding metformin, laparoscopic ovarian drilling or treatment with gonadotropins. In CC treatment failure, Letrozole could be an alternative or treatment with gonadotropins. IVF is considered the third-line treatment; the 'short', antagonist-based protocol is the preferred option for PCOS patients, as it is associated with lower risk of developing ovarian hyperstimulation syndrome (specifically by using a gonadotropin--releasing hormone agonist as ovulation trigger), but with comparable outcomes as the long protocol.

  19. Patient evaluation of infertility management in an ISO 9001:2008-certified centre for reproductive medicine.

    Science.gov (United States)

    Van den Broeck, Uschi; Spiessens, Carl; Dancet, Eline; Bakelants, Els; Vrancken, Annelies; Demyttenaere, Koen; Enzlin, Paul; D'Hooghe, Thomas

    2012-03-01

    Quality management according to ISO 9001:2008 guidelines includes infertility care quality assessment and improvement. This study aimed to describe the development process of a questionnaire for infertility management. A literature review, qualitative interviews with experts and patients resulted in a content-valid and face-valid questionnaire. Three cross-sectional surveys were performed in 2004, 2007 and 2008 in a tertiary university infertility centre. First (2004), the questionnaire – measuring eight a-priori dimensions of infertility management – was tested. Second (2007), improvement projects for infertility management were evaluated. Third (2008), factor analysis was performed and internal consistency was documented. The developed patient questionnaire to evaluate infertility management and pre-set desired levels of agreement served to set targets for and assess quality improvement projects. The final patient questionnaire to evaluate infertility management within an ISO framework was valid and reliable and contained 14 items covering four dimensions of infertility management: Telephone Access, Reception, Information and Patient-centeredness. ISO 9001:2008-certified infertility centres can evaluate infertility management with this 14-item questionnaire. This top-down approach to evaluate the patients’ perspective on quality aspects selected by health professionals can be complementary to the bottom-up approach evaluating the patients’ complete experiences of quality of care.

  20. A Nutrition Screening Form for Female Infertility Patients.

    Science.gov (United States)

    Langley, Susie

    2014-12-01

    A Nutrition Screening Form (NSF) was designed to identify lifestyle risk factors that negatively impact fertility and to provide a descriptive profile of 300 female infertility patients in a private urban infertility clinic. The NSF was mailed to all new patients prior to the initial physician's visit and self-reported data were assessed using specific criteria to determine if a nutrition referral was warranted. This observational study revealed that 43% of the women had a body mass index (BMI) history of "dieting" and unrealistic weight goals potentially limiting energy and essential nutrients. A high number reported eating disorders, vegetarianism, low fat or low cholesterol diets, and dietary supplement use. Fourteen percent appeared not to supplement with folic acid, 13% rated exercise as "extremely" or "very active", and 28% reported a "high" perceived level of stress. This preliminary research demonstrated that a NSF can be a useful tool to identify nutrition-related lifestyle factors that may negatively impact fertility and identified weight, BMI, diet, exercise, and stress as modifiable risk factors deserving future research. NSF information can help increase awareness among health professionals and patients about the important link between nutrition, fertility, and successful reproductive outcomes.

  1. The Analysis of Sialylation, N-Glycan Branching, and Expression of O-Glycans in Seminal Plasma of Infertile Men

    Directory of Open Access Journals (Sweden)

    Ewa M. Kratz

    2015-01-01

    Full Text Available Carbohydrates are known to mediate some events involved in successful fertilization. Although some studies on the glycosylation of seminal plasma proteins are available, the total glycan profile was rarely analyzed as a feature influencing fertilization potential. In this work we aimed to compare some glycosylation traits in seminal plasma glycoproteins of fertile and infertile men. The following findings emerge from our studies: (1 in human seminal plasma the presence and alterations of O-linked glycans were observed; (2 the expression of SNA-reactive sialic acid significantly differs between asthenozoospermia and both normozoospermic (fertile and infertile groups; (3 the expression of PHA-L-reactive highly branched N-glycans was significantly lower in oligozoospermic patients than in both normozoospermic groups. Indication of the appropriate lectins that would enable the possibly precise determination of the glycan profile seems to be a good supplement to mass spectrum analysis. Extension of the lectin panel is useful for the further research.

  2. Patient evaluation of infertility management in an ISO 9001:2008-certified centre for reproductive medicine

    NARCIS (Netherlands)

    Broeck, U. van den; Spiessens, C.; Dancet, E.; Bakelants, E.; Vrancken, A.C.; Demyttenaere, K.; Enzlin, P.; D'Hooghe, T.

    2012-01-01

    Quality management according to ISO 9001:2008 guidelines includes infertility care quality assessment and improvement. This study aimed to describe the development process of a questionnaire for infertility management. A literature review, qualitative interviews with experts and patients resulted in

  3. Patient evaluation of infertility management in an ISO 9001:2008-certified centre for reproductive medicine

    NARCIS (Netherlands)

    Broeck, U. van den; Spiessens, C.; Dancet, E.; Bakelants, E.; Vrancken, A.C.; Demyttenaere, K.; Enzlin, P.; D'Hooghe, T.

    2012-01-01

    Quality management according to ISO 9001:2008 guidelines includes infertility care quality assessment and improvement. This study aimed to describe the development process of a questionnaire for infertility management. A literature review, qualitative interviews with experts and patients resulted in

  4. Postcoital recovery of sperm in Douglas pouch aspirates of infertile patients.

    Science.gov (United States)

    Aref, I; Reda, M; Kandil, O; El Tagi, A

    1984-02-01

    Tubal dysfunction is certainly involved in some cases of infertility. Clinical diagnostic procedures for tubal patency are occasionally misleading and contradictory. Moreover, they provide no information on tubal function. The recovery of viable sperm in Douglas pouch aspirates (DPA) was used to evaluate tubal function in 94 infertile patients with different tubal findings at hysterosalpingography (HS) and laparoscopy. Sperm recovery in DPA of ten infertile patients with poor or negative postcoital Sims- Huhner test results demonstrated the limitation of this test for evaluation of sperm transport in the female genital tract. Laparoscopic aspiration of DP may be performed in infertile patients undergoing chromosalpingoscopy as a part of their infertility investigation. The procedure should be supplementary to other available diagnostic parameters.

  5. Patients from across Europe have similar views on patient-centred care: an international multilingual qualitative study in infertility care.

    NARCIS (Netherlands)

    Dancet, E.A.; D'Hooghe, T.M.; Sermeus, W.; Empel, I. van; Strohmer, H.; Wyns, C.; Santa-Cruz, D.; Nardo, L.G.; Kovatchki, D.; Vanlangenakker, L.; Garcia-Velasco, J.; Mulugeta, B.; Nelen, W.L.D.M.; Kremer, J.A.M.

    2012-01-01

    BACKGROUND: International patient centredness concepts were suggested but never conceptualized from the patients' perspective. Previously, a literature review and a monolingual qualitative study defined 'patient-centred infertility care' (PCIC). The present study aimed to test whether patients from

  6. Transrectal ultrasonography in infertile patients with persistently elevated bacteriospermia

    Institute of Scientific and Technical Information of China (English)

    Sandro La Vignera; Aldo E. Calogero; Alessandro Arancio; Roberto Castighone; Gaetano De Grande; Enzo Vicari

    2008-01-01

    Aim: To identify and define prostate and seminal vesicle abnormalities in patients with chronic male accessory gland infection (MAGI) who failed to respond to antibacterial treatment. Methods: We selected 67 consecutive patients with MAGI and persistently elevated bacteriospermia (≥ 106 colony forming units [CFU]/mL) after three antibiotic courses. Fourteen infertile patients with initial chronic microbial (≥ 106 CFU/mL) MAGI who responded to antibac- terial treatment (< 103 CFU/mL) served as a control group. All patients and controls underwent transrectal ultrasonog- raphy (TRUS) scans and semen analysis. Patients with low seminal plasma volume (< 1.5 mL) underwent both pre- ejaculatory and post-ejaculatory TRUS examination. Results: TRUS revealed multiple abnormalities indicative of: (I) bilaterally extended prostato-vesiculitis (group A: 52 cases, 77.6%) (nine of these patients also had micro-emphyse- matous prostate abscess); and (ii) prostato-vesiculitis with unilateral or bilateral sub-obstruction of the ejaculatory ducts (group B: 15 cases, 22.4%). Mean sperm concentration, total sperm number, ejaculate volume and pH value were significantly higher in group A than in group B. In addition, sperm forward motility and the percentage of normal forms were significantly worse than in controls, whereas leukocyte concentration was significantly higher in group A. Group B patients had all sperm parameters, but their pH values, significantly different from those of controls. Confusion: Although antibiotic therapy is considered suitable when microbial MAGI is suspected, it is impossible to account for a poor response to antibiotics merely on the basis of conventional criteria (clinical history, physical and ejaculate signs). Thus, TRUS may be helpful in the follow-up of these patients.

  7. Physician and patient use of and attitudes toward complementary and alternative medicine in the treatment of infertility.

    Science.gov (United States)

    Clark, Natalie A; Will, Matthew A; Moravek, Molly B; Xu, Xiao; Fisseha, Senait

    2013-09-01

    To determine use of and attitudes toward complementary and alternative medicine (CAM) among infertility patients and subspecialty physicians. Infertility patients were asked to complete anonymous written surveys at an academic infertility practice; members of the Society for Reproductive Endocrinology and Infertility were electronically surveyed. Both groups were assessed regarding their use of and attitudes toward CAM. The response rate was 32.1% (115/358) among patients and 22.6% (225/995) among physicians (Pinfertility patients requires greater physician attention and justifies further study on the risks and benefits of integrating CAM into the biomedical treatment of infertility. Published by Elsevier Ireland Ltd.

  8. Impact of seminal trace element and glutathione levels on semen quality of Tunisian infertile men

    Directory of Open Access Journals (Sweden)

    Atig Fatma

    2012-03-01

    Full Text Available Abstract Background Growing evidence indicates that oxidative stress can be a primary cause of male infertility. Non-enzymatic antioxidants play an important protective role against oxidative damages and lipid peroxidation. Human seminal plasma is a natural reservoir of antioxidants. The aim of this study was to determine glutathione (GSH concentrations, trace element levels (zinc and selenium and the lipid peroxidation end product, malondialdehyde (MDA, in the seminal plasma of men with different fertility potentials. Methods Semen samples from 60 fertile men (normozoospermics and 190 infertile patients (74 asthenozoospermics, 56 oligozoospermics, and 60 teratozoospermics were analyzed for physical and biochemical parameters. Zinc (Zn and selenium (Se levels were estimated by atomic absorption spectrophotometry. Total GSH (GSHt, oxidized GSH (GSSG, reduced GSH (GSHr and MDA concentrations were measured spectrophotometrically. Results Zn and Se concentrations in seminal plasma of normozoospermics were more elevated than the three abnormal groups. Nevertheless, only the Zn showed significant differences. On the other hand, Zn showed positive and significant correlations with sperm motility (P = 0.03, r = 0.29 and count (P Conclusions This report revealed that decreased seminal GSH and trace element deficiencies are implicated in low sperm quality and may be an important indirect biomarker of idiopathic male infertility. Our results sustain that the evaluation of seminal antioxidant status in infertile men is necessary and can be helpful in fertility assessment from early stages.

  9. Relationship between ROS production, apoptosis and DNA denaturation in spermatozoa from patients examined for infertility

    National Research Council Canada - National Science Library

    Moustafa, Mohamed H; Sharma, Rakesh K; Thornton, Julie; Mascha, Edward; Abdel-Hafez, Mohammed A; Thomas, Jr, Anthony J; Agarwal, Ashok

    2004-01-01

    ...) in inducing DNA damage in ejaculated spermatozoa. We examined ejaculated spermatozoa from 31 patients examined for infertility and 19 healthy donors for apoptosis, production of ROS and DNA damage using annexin V binding, chemiluminescence assay...

  10. Management of infertility in a patient presenting with ovarian dysfunction and McCune-Albright syndrome

    NARCIS (Netherlands)

    J.S.E. Laven (Joop); S. Lumbroso; C. Sultan; B.C.J.M. Fauser (Bart)

    2004-01-01

    textabstractPersistent autonomous ovarian dysfunction in McCune-Albright syndrome (MAS) patients is associated with the development of multiple dominant follicles, premature luteinization, cyst formation, and anovulatory infertility. Due to the mosaic distribution of the mutation,

  11. [Citogenetic and molecular genetic studies in infertility in eastern Hungary].

    Science.gov (United States)

    Mokánszki, Attila; Ujfalusi, Anikó; Balogh, Erzsébet; Molnár, Zsuzsanna; Sápy, Tamás; Jakab, Attila; Varga, Attila; Oláh, Eva

    2013-01-13

    In developed countries 10-15% of the couples are affected by infertility. In half of them genetic factors can be identified. We studied genetic alterations in infertility in Hungarian patients. Cyogenetic analyses were performed in 195 females and 305 males. In 17 females FMR1 mutations, in 150 males Y microdeletions, and aneuploidy were studied in the sperm of 28 males. In a carrier male sperm meiotic segregation was studied. The most common aberrations in females were X chromosome aneuploidia and inversion (3.6%), while the same in males Klinefelter-syndrome (3.3%) and autosomal translocations (2%). In two females FMR1 premutation was found. While Y microdeletions were identified only in azoospermic and severe oligozoospermic men, partial microdeletions could also be detected in normozoospermic males. A higher aberration rate was found in cases with abnormality in both the number and motility of sperm. In a male patient with 46,XY,t(3;6)(q21;q23) karyotype, 53.2% of spem carried unbalanced chromosome assortment. Knowledge of abnormalities may help in genetic counseling and choosing the most effective reproduction technique.

  12. CHROMOSOME ABNORMALITIES IN INFERTILITY

    Directory of Open Access Journals (Sweden)

    Mateja Smogavec

    2009-08-01

    Conclusions Chromosomal analysis is an important method in diagnostic procedures of infertility, because chromosomal abnormalities could play the important role in etiology of infertility and are more frequently detected in this group of patients compared to general population. In the infertile couples balanced chromosomal abnormalities are the main cause of spontaneous abortions. Sex chromosome aneuploidies are highly correlated to infertility of females and males.

  13. The role of the anti-sperm autoantibodies in the management of patients with primary infertility.

    Science.gov (United States)

    Hameed, N; Ahmed, T A; Sultana, N; Khan, D A; Khan, N A; Hassan, W

    1995-08-01

    The role of antibody mediated infertility in patients with primary/secondary unexplained infertility is the subject of current interest worldwide. A prospective study was conducted to study the role of anti sperm antibodies in Pakistani patients with infertility. Patients reporting in the outpatient clinic of a local gynaecology department with problem of infertility were subjected to a detailed scrutiny by history and clinical examination including post-coital test and hysterosalpingography. Hormonal profile consisting of serum FSH, LH, Prolactin and Progesterone was assessed. Most of the ladies also underwent a pelviscopic examination. A total of 117 patients were selected where post-coital test was abnormal, semen analysis was not satisfactory or who had unexplained infertility. Tests were performed on the serum specimen from the husbands, wives and in some cases on the seminal plasma as well, for the measurement of the anti sperm agglutinating and anti-sperm immobilizing antibodies by the microagglutination technique. Fifteen of these patients were found positive for these antibodies, 7 were positive for the agglutinating antibody, 6 for the immobilizing antibody and two for both types. These results indicate that immunomodulation may be responsible for some cases of infertility in our population.

  14. Anxiety and depression after failure of assisted reproductive treatment among patients experiencing infertility.

    Science.gov (United States)

    Maroufizadeh, Saman; Karimi, Elaheh; Vesali, Samira; Omani Samani, Reza

    2015-09-01

    To investigate the impact of the number of previous infertility treatment failures on anxiety and depression. In a cross-sectional study, individuals (men and women, but not couples) aged at least 18 years who had a history of infertility and could read and write in Persian were enrolled at the Royan Institute, Tehran, Iran, between November 1, 2013, and February 28, 2014. Participants provided demographic and infertility information and completed the Persian version of the Hospital Anxiety and Depression Scale (HADS). Overall, 330 patients (122 men, 208 women) were included. Mean scores on the HADS anxiety and depression subscales (HADS-A and HADS-D) were 8.40±4.51 and 5.95±3.54, respectively. In multiple regression analysis, mean HADS-A scores were significantly higher for patients with one treatment failure (9.57±4.58) than for those without a history of treatment (7.79±4.13; P=0.003). HADS-D scores were significantly higher for patients with two failures (6.92±3.69) than for those with no previous treatment (5.59±3.79; P=0.019). Patients with infertility have increased depression and anxiety after infertility treatment failure. Counseling or treatment for these potential psychological effects should be considered after infertility treatment failure. Copyright © 2015 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

  15. Sperm counts and sperm sex ratio in male infertility patients

    Institute of Scientific and Technical Information of China (English)

    Michael L Eisenberg; Lata Murthy; Kathleen Hwang; Dolores J Lamb; Larry I Lipshultz

    2012-01-01

    In recent years,investigators have noted a trend toward a declining proportion of male births in many industrialized nations.While men bear the sex-determining chromosome,the role of the female partner as it pertains to fertilization or miscarriage may also alter the gender ratio.We attempted to determine a man's secondary sex ratio (F1 generation) by directly examining the sex chromosomes of his sperm.We examined our male infertility clinic database for all men who had undergone a semen fluorescence in situ hybridization (FISH).Patient demographic and semen parameters were recorded.Chi-squared analysis was used to compare gender ratios (Ychromosomes/total chromosomes).Multivariable logistic regression was used to predict the odds of possessing a Y-bearing sperm after accounting for demographic and semen parameters.A total of 185 men underwent sperm FISH.For the entire cohort,the proportion of Y chromosome-bearing sperm was 51.5%.Men with less than five million motile sperm had a significantly lower proportion of Y chromosome-bearing sperm (50.8%) compared to men with higher sperm counts (51.6%; P=0.02).After multivariable adjustment,a higher sperm concentration,total motile sperm count and semen volume significantly increased the odds of having a Y chromosome-bearing sperm (P<0.01).As a man's sperm production declines,so does the proportion of Y chromosome-bearing sperm.Thus,a man's reproductive potential may predict his ability to sire male offspring.

  16. Ultrasound characterization of the seminal vesicles in infertile patients with type 2 diabetes mellitus

    Energy Technology Data Exchange (ETDEWEB)

    La Vignera, Sandro; Vicari, Enzo; Condorelli, Rosita; D' Agata, Rosario [Section of Endocrinology, Andrology and Internal Medicine and Master in Andrological, Human Reproduction and Biotechnology Sciences, Department of Biomedical Sciences, University of Catania, Catania (Italy); Calogero, Aldo E., E-mail: acaloger@unict.it [Section of Endocrinology, Andrology and Internal Medicine and Master in Andrological, Human Reproduction and Biotechnology Sciences, Department of Biomedical Sciences, University of Catania, Catania (Italy)

    2011-11-15

    Male patients with type 2 diabetes mellitus (DM) may experience infertility because the disease affects negatively many aspects of reproduction, including seminal vesicle (SV) function. The aim of this study was to evaluate the ultrasound characteristics of the SVs of infertile patients with DM because no such data are available in these patients. To accomplish this, 25 infertile patients with type 2 DM and no other known causes of sperm parameter abnormalities were selected. Two different control groups were also enrolled: healthy men with idiopathic infertility (n = 25) and infertile patients with male accessory gland infections (MAGI) (n = 25), a well-studied clinical model of SV inflammation. Patients and controls underwent prostate-vesicular transrectal ultrasonography after 1 day of sexual abstinence before and 1 h after ejaculation. The following SV ultrasound parameters were recorded: (1) body antero-posterior diameter (ADP); (2) fundus APD; (3) parietal thickness of the right and left SVs; (4) number of polycyclic areas within both SVs; (5) fundus/body ratio; (6) difference of the parietal thickness between the right and the left SV; and (7) pre- and post-ejaculatory APD difference. Patients with DM had a significantly (p < 0.05) higher F/B ratio compared to controls and patients with MAGI. Only patients with MAGI had a significantly (p < 0.05) higher number of polycyclic areas. Controls and MAGI patients have a similar pre- and post-ejaculatory difference of the body SV APD, whereas this difference was significantly (p < 0.05) lower in patients with DM. In conclusion, this study showed that infertile patients with DM have peculiar SV ultrasound features suggestive of functional atony.

  17. Increased Prevalence of Celiac Disease in Patients with Unexplained Infertility in the United States: A Prospective Study

    Science.gov (United States)

    Lebwohl, Benjamin; Wang, Jeffrey; Lee, Susie K.; Murray, Joseph A.; Sauer, Mark V.; Green, Peter H. R.

    2011-01-01

    Celiac disease is an autoimmune disorder which can present with a variety of non-gastrointestinal manifestations. In women, it may manifest with an assortment of gynecologic or obstetric disorders. Some reports have linked female infertility with undiagnosed celiac disease. Though there are a number of studies from Europe and the Middle East, only two prior American studies have examined the prevalence of “silent” celiac disease in a female infertility population. We prospectively performed serologic screening for celiac disease in 188 infertile women (ages 25–39). While we did not demonstrate an increased prevalence of celiac disease in our overall infertile female population, we were able to detect a significantly increased prevalence (5.9%) of undiagnosed celiac disease among women presenting with unexplained infertility (n=51). Our findings suggest the importance of screening infertile female patients, particularly those with unexplained infertility, for celiac disease. PMID:21682114

  18. Prevalence and distribution of Chlamydia trachomatis genovars in Indian infertile patients: a pilot study.

    Science.gov (United States)

    Rawre, Jyoti; Dhawan, Benu; Malhotra, Neena; Sreenivas, Vishnubhatla; Broor, Shobha; Chaudhry, Rama

    2016-12-01

    To determine the prevalence and distribution of Chlamydia trachomatis genovars in patients with infertility by PCR-RFLP and ompA gene sequencing. Prevalence of other etiological agents (viz., Ureaplasma spp. and Mycoplasma hominis) were also assessed. Endocervical swabs were collected from 477 women and urine was collected from 151 men attending the Infertility Clinic. The samples were screened for C. trachomatis by cryptic plasmid, ompA gene and nested ompA gene PCR. Genotyping was performed by PCR-RFLP and sequencing. Samples were screened for Ureaplasma spp. and M. hominis. The prevalence of C. trachomatis in infertile women and their male partners were 15.7% (75 of 477) and 10.0% (15 of 151) respectively. Secondary infertility was significantly associated with chlamydial infection. Genovar E was the most prevalent followed by genovar D and F. Twenty-four C. trachomatis strains were selected for ompA gene sequencing. No mixed infection was picked. Variability in ompA sequences was seen in 50.0%. Both PCR-RFLP and ompA gene sequencing showed concordant results. High prevalence of C. trachomatis in infertile couples warrants routine screening for C. trachomatis infection in all infertile couples. Genotyping of the ompA gene of C. trachomatis may be a valuable tool in understanding the natural history of C. trachomatis infection.

  19. Cytogenetic and molecular screening of the DAZ gene family in a population of infertile males

    Directory of Open Access Journals (Sweden)

    Nubia Amparo Ruiz Suárez

    2007-05-01

    Full Text Available The purpose of this study was to evalúate the frequency of Y chromosome structural, numerical, chromosomal and genetic abnormalities, as well as DAZ gene microdeletions in the Y chromosome in a population of infertile males. Genetic abnormalities have been established to date in up to 24% of males having severe abnormalities in their sperm (Dohle et al. 2002; deletion of the DAZ gene family (deleted in azoospermia is the most common cause. It has been found in 6% of the oligozoospermias and in 12% of the azoospermias (Van Landuyt et al. 2000. A popula­tion of 20 azoospermic and 10 oligozoospermic males was studied. Five males having normal sperm parameters were used as controls. Each sample was karyotyped (QFQ banding and underwent sY254, sY255 and sY257 mo­lecular amplification. Genetic study revealed alterations in 16.6% of the cases: 6.6% at chromosome level and 10% at molecule level. No chromosomal or molecular gene alterations were detected in control males. The frequencies found lead to a broader population-based study being recommended. They confirmed the need for performing judicious genetic counselling in infertile couples with male factor infertility to avoid or minimise the risks of trans-mitting these abnormalities to offspring and provide better prognosis for assisted reproductive techniques in such patients. Key words: azoospermia; oligozoospermia; microdeletions; ICSI

  20. PCR analysis of Yq microdeletions in infertile males,a study from South India

    Institute of Scientific and Technical Information of China (English)

    BabuSR; SwarM

    2002-01-01

    Aim:To estimate the frequency of microdeletions in the long arm of Y-chromosome of 20 infertile males from South India.Methods:Polymerase chain reaction (PCR) amplification using Y-specific STS of azoospermia factor (AZF) regions i.e.,SY 84 for AZFa,SY 127 for AZFb and SY 254 for AZFc.Results:Of the 20 infertile subjects 3(15%),one azoospermic and two oligozoospermic,showed microdeletions in the AZF region of Y-chromosome.Conclusion:The frequency of deletions involving AZF region of the Y-chromosome is 15% in azoospermic and severely oligozoospermic infertile men.PCR amplification of AZF locus is useful for the diagnosis of microdeletions in the Y-chromosome.

  1. Don't Give Up! A Cyber-ethnography and Discourse Analysis of an Online Infertility Patient Forum.

    Science.gov (United States)

    Lee, Mihan

    2017-01-06

    Infertility affects women across the socioeconomic spectrum; however, it is by no means egalitarian in its distribution, nor uniform in its lived experience. Evidence shows striking disparities by income, race, and education in infertility prevalence, access to infertility services, and success rates after receiving infertility treatments. However, few studies so far have investigated disparities in patients' access to psychological support during the infertility journey. This paper undertakes a cyber-ethnography of the online patient forum, "Finding a Resolution for Infertility," hosted by RESOLVE: The National Infertility Association. It also draws from interviews with 54 infertility patients recruited from the forum. Our aim was to examine how social support operates within this virtual realm, by examining how the forum's language, norms, and values create and enforce categories of deserving and belonging among site users. We find that the forum's discourse privileges an infertility narrative we term the "persistent patient," in which a patient exhaustively researches treatment options, undergoes multiple cycles of treatment despite repeated failures, and ultimately achieves success (a healthy baby). Meanwhile, there is little to no discursive space for discussion of the financial and social resources necessary to act in accordance with this script. Thus, women without such resources can be alienated, silenced, and denied mental health support by this online community.

  2. Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts

    OpenAIRE

    Punab, M.; Poolamets, O; Paju, P.; Vihljajev, V.; Pomm, K.; Ladva, R.; Korrovits, P.; Laan, M

    2016-01-01

    STUDY QUESTION What are the primary causes of severe male factor infertility? SUMMARY ANSWER Although 40% of all patients showed primary causes of infertility, which could be subdivided into three groups based on the severity of their effect, ~75% of oligozoospermia cases remained idiopathic. WHAT IS KNOWN ALREADY There are few large-scale epidemiological studies analyzing the causes of male factor infertility. STUDY DESIGN, SIZE, DURATION A prospective clinical-epidemiological study was cond...

  3. Defining Infertility

    Science.gov (United States)

    ... Home FAQs Frequently Asked Questions Quick Facts About Infertility FAQs About Infertility FAQs About the Psychological Component of Infertility FAQs About Cloning and Stem Cell Research SART's ...

  4. Classification of Patients Treated for Infertility Using the IVF Method

    Directory of Open Access Journals (Sweden)

    Malinowski Paweł

    2015-12-01

    Full Text Available One of the most effective methods of infertility treatment is in vitro fertilization (IVF. Effectiveness of the treatment, as well as classification of the data obtained from it, is still an ongoing issue. Classifiers obtained so far are powerful, but even the best ones do not exhibit equal quality concerning possible treatment outcome predictions. Usually, lack of pregnancy is predicted far too often. This creates a constant need for further exploration of this issue. Careful use of different classification methods can, however, help to achieve that goal.

  5. ROLE OF FINE NEEDLE ASPIRATION CYTOLOGY IN THE EVALUATION OF MALE INFERTILITY

    Directory of Open Access Journals (Sweden)

    Prasad

    2015-03-01

    Full Text Available BACKGROUND: Male infertility is a common problem and needs a minimally invasive method to arrive at the appropriate diagnosis . Alternative to open testicular biopsy the fine needle aspiration cytology of the testis is being increasingly used as a minimally invasive method of evaluating testicular function . AIM OF THE STUDY: To know whether FNAC of testes is as informative as biopsy in cases of male infertility . To establish that FNAC is cost effective , safe , out p atient investigation with no complications . METHODOLOGY: Fifty patients with primary male infertility in the age group of 20 - 40 years were included in the study . All the cases with oligospermia and azoospermia were subjected for Doppler study to rule out varicocele . Cord block was achieved with 1% lignocaine and aspiration was done with 23 gauge 1 . 5 inch needle . Smears were made on albuminised slides and stained with Leishman Stain . Forresta et al scoring system was adopted to analyse the smears . In the same sitting testicular biopsy was taken , fixed in Bouins fluid , routinely processed and stained with H&E stain . RESULTS: The commonest group with infertility were in the age group 21 - 30 years . On semen analysis 78% were azoospermic and 22% were oligozoospermic . The testicular size was normal in 90 % of subjects and 10% had small testis . Out of fifty subjects with infertility , 40% subjects had varicocele . Varicocele was commonly associated with duct obstruction . The commonest patterns observed on cytology were; normal spermatogenesis ( 14/50 , 28 % , duct obstruction ( 8/50 , 16 % , maturation arre st ( 7/50 , 14 % and testicular atrophy ( 7/50 , 14 % . In the present study diagnostic accuracy was 93 . 4% . CONCLUSION: Fine needle aspiration cytology is as informative as biopsy and can be done as a routine procedure . It is a simple and cost effective . In cases where FNAC shows normal spermatogenesis with azoospermia and oligospermia , biopsy and doppler study

  6. UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men

    Science.gov (United States)

    Yatsenko, Alexander N.; Georgiadis, Andrew P.; Murthy, Lata J.; Lamb, Dolores J.; Matzuk, Martin M.

    2013-01-01

    Oligozoospermia (low sperm count) is a common semen deficiency. However, to date, few genetic defects have been identified to cause this condition. Moreover, even fewer molecular genetic diagnostic tests are available for patients with oligozoospermia in the andrology clinic. Based on animal and gene expression studies of oligozoospermia, several molecular pathways may be disrupted in post-meiotic spermatozoa. One of the disrupted pathways is protein ubiquitination and cell apoptosis. A critical protein involved in this pathway is the ubiquitin-conjugating enzyme 2B, UBE2B. Absence of Ube2b in male mice causes spermatogenic meiotic disruption with increased apoptosis, leading to infertility. To examine the association between messenger RNA defects in UBE2B and severe oligozoospermia (0.1–10 × 106 cells/ml), sequencing of sperm cDNA in 326 oligozoospermic patients and 421 normozoospermic men was performed. mRNA alterations in UBE2B were identified in sperm in 4.6% (15 out of 326) of the oligozoospermic patients, but not found in control men, suggesting strong association between mRNA defects and oligozoospermia (χ2 = 19, P = 0.0001). Identified UBE2B alterations include nine splicing, four missense and two nonsense alterations. The follow-up screen of corresponding DNA regions did not reveal causative DNA mutations, suggesting a post-transcriptional nature of identified defects. None of these variants were reported in the dbSNP database, although other splicing abnormalities with low level of expression were present in 11 out of 421 (2.6%) controls. Our findings suggest that two distinct molecular mechanisms, mRNA editing and splicing processing, are disrupted in oligozoospermia. We speculate that the contribution of post-transcriptional mRNA defects to oligozoospermia could be greater than previously anticipated. PMID:23378580

  7. Outcome of the IVF for the Patients with Endometrioma Associated Infertility

    Institute of Scientific and Technical Information of China (English)

    Yan-hong MAO; Chun ZHOU; Annie Zaccabri

    2009-01-01

    Objective To evaluate the ovarian response to the gonadotrophin (Gn) in the COH and observe the outcome of lVF for the patients with endometriomas. Methods A retrospective analysis of 32 patients with endometrioma undergoing IVF-ET. It included 71 cycles, and 59 cycles in 32 patients with tubal factor associated infertility were as the control. Results There were statistically significant differences between the two groups in the cancelling rate (P0.05. Conclusion The patients with endometriomas had a poor response to the Gn in the COH. The endometrial accessibility in patients with endometriomas seemed not to beaffected by the presence of endometriomas. But considering the higher cancellingrate, the prognostic for the patients with endometriomas was worth than the patientswith tubal factor associated infertility.

  8. Accurate Diagnosis as a Prognostic Factor in Intrauterine Insemination Treatment of Infertile Saudi Patients

    OpenAIRE

    Isa, Ahmed Mostafa; Abu-Rafea, Basim; Alasiri, Saleh Ahmed; Al-Mutawa, Johara; Binsaleh, Saleh; Al-Saif, Sameera; Al-Saqer, Aisha

    2014-01-01

    Background The study meant to define the prognostic factors that help in prescribing intrauterine insemination (IUI) for infertility treatment which remains an area of continuous improvements. Methods The diagnostic indications of a cohort of IUI-treated patients and their corresponding pregnancy rates (PRs) were randomly and prospectively studied among Saudi cohort of 303 patients for a period of 20 months. The indications of IUI cases were statistically analyzed for those eligible patients ...

  9. Clinical Factors Associated with Sperm DNA Fragmentation in Male Patients with Infertility

    Science.gov (United States)

    Komiya, Akira; Kato, Tomonori; Kawauchi, Yoko; Watanabe, Akihiko; Fuse, Hideki

    2014-01-01

    Objective. The clinical factors associated with sperm DNA fragmentation (SDF) were investigated in male patients with infertility. Materials and Methods. Fifty-four ejaculates from infertile Japanese males were used. Thirty-three and twenty-one were from the patients with varicoceles and idiopathic causes of infertility, respectively. We performed blood tests, including the serum sex hormone levels, and conventional and computer-assisted semen analyses. The sperm nuclear vacuolization (SNV) was evaluated using a high-magnification microscope. The SDF was evaluated using the sperm chromatin dispersion test (SCDt) to determine the SDF index (SDFI). The SDFI was compared with semen parameters and other clinical variables, including lifestyle factors. Results. The SDFI was 41.3 ± 22.2% (mean ± standard deviation) and did not depend on the cause of infertility. Chronic alcohol use increased the SDFI to 49.6 ± 23.3% compared with 33.9 ± 18.0% in nondrinkers. The SDFI was related to adverse conventional semen parameters and sperm motion characteristics and correlated with the serum FSH level. The SNV showed a tendency to increase with the SDFI. The multivariate analysis revealed that the sperm progressive motility and chronic alcohol use were significant predictors of the SDF. Conclusion. The SCDt should be offered to chronic alcohol users and those with decreased sperm progressive motility. PMID:25165747

  10. Assessment of reproductive results of infertile patients who had undergone operative hysteroscopy for intrauterine pathology

    Directory of Open Access Journals (Sweden)

    Röyale Seferli

    2015-03-01

    Full Text Available Objectives: We aimed to evaluate the reproductive outcomes of infertile patients who had undergone operative hysteroscopy (HS with the diagnoses of uterine septum, endometrial polyp, submucous myoma, and intrauterine adhesion. Methods: This retrospective study included 334 patients who had been diagnosed with primary and secondary infertility, aged between 18–35 years and diagnosed with uterine septum (group 1, endometrial polyp (group 2, submucous myoma (group 3, and intrauterine adhesion (group 4 by hysterosalpingography or office HS and who were treated via hysteroscopic operation between January 2009 and January 2013. Pregnancy results were obtained from the patients’ files and hospital database; when this was not possible, the patients were queried by phone calls. Groups were then compared in terms of characteristics, prognoses, and pregnancy outcomes. Results: The cumulative pregnancy rate was 58.7% in infertile patients who underwent operative HS due to intrauterine pathology. The mean length of time from operation to conception was 10.8±9.6 months in all groups. Mean age, infertility duration, infertility type, and smoking status were statistically different among the groups (p<0.05. Following surgery, 95 (66.4% of 143 patients in group 1 conceived and 57 (60% of these pregnancies resulted in term birth. There were 64 (54.2% pregnancies in group 2 and 34 (53.1% resulted in term birth. Sixteen (47.1% patients conceived in group 3, and 6 (37.5% of them had term birth. Twenty-one (53.8% patients conceived in group 4. Twelve out of 21 patients (57.1% had term birth. The most common mode of delivery was cesarean section in all groups. Conclusion: Thus, operative HS increases pregnancy rates in patients with intrauterine pathology. In future, large-scale prospective studies should be carried out to reveal the effects of the hysteroscopic method and compare this approach with other methods in order to achieve better pregnancy outcomes in

  11. Study of association between ovarian volume with the number of antral follicles and third day of menstruation FSH in infertile patients referred to Omid Persian gulf infertility Clinic

    Directory of Open Access Journals (Sweden)

    Elham Rahmani

    2016-09-01

    Full Text Available Background: Ovarian reserve tests have appeared as important, useful and new tools in evaluation of infertile women and by doing these tests, we can do for infertile couples advanced and necessary measures quickly. The goal of this study was to investigate the association between ovarian volume, Antral follicle counts and serum level of FSH at the third day of menstruation. Material and Methods: This study was conducted on 78 women between 18-49 years old who referred to Omid Persian gulf infertility Clinic with complaining of infertility in 2014. In patients who had inclusion criteria, measurement of ovarian volume were done with calculation of three diameters and the number of antral follicles by using vaginal ultrasound in third day of menstruation. Also, in this patients were measured the levels of FSH&LH in third day of menstruation. Pearson correlation coefficient were used to examine the relationship between ovarian volume and the number of Antral follicles and serum levels. Results: ovarian volume and Antral follicle counts (p=0.0001 decreased and serum level of FSH (p=0.0001 and LH (p=0,022 increased significantly with increasing of age. There was a strong positive correlation between ovarian volume and Antral follicle counts (r=0.96, p=0.0001 and there was a strong reversed correlation between ovarian volume and Antral follicle counts with FSH (r=0.50, p=0.0001. Conclusion: By increasing age, ovarian volume and Antral follicle counts decreased and FSH&LH levels increased. In fact, in the initial study of infertile patients, even by diagnosis of reduction in ovarian volume and Antral follicle count should be performed advanced therapies and there is no need to wait for expensive tests result.

  12. Effects of integrative medicine treatment on 48 infertile patients with diminished ovarian reserve

    Institute of Scientific and Technical Information of China (English)

    YU Jin; PAN Fang

    2008-01-01

    Objective:To observe the effect of integrative medicine treatment on infertile patients with diminished ovarian reserve(DOR).Methods:Forty-eight infertile patients with DOR were treated with integrative medicine from May 2004 to December 2006 in our center.Patients were divided into 3 groups:failed IVF-ET in 16 cases(IVF group),prema-ture ovarian failure in 9 cases(POF group)and DOR due to other causes in 23.cases(OV ↓ group).Yu's Follicle Replenishing Recipe(YFRR)was administered daily in all cases,and usually different dosages of estrogen were dia-lectically added according to the view of life network regulation.Symptoms,BBT,ovulation rate,pregnancy rate and serum sex hormones measuring on cycle Day 3(or day 3 after withdrawal bleeding)were observed before and af-ter treatment.Results:During the treatment,symptoms were gratefully relieved in all 48 patients,and the pregnancy rate was 40%.Ovulation rate significantly increased from 17%(8/48 before treatment)to 56 %(27/48 after treatment)(P0.05).Conclusion:The integrative medicine treatment not only increases ovulation rate and pregnancy rate in infertile patients with DOR,but also calms down their symptoms.

  13. Oral antioxidant treatment partly improves integrity of human sperm DNA in infertile grade I varicocele patients.

    Science.gov (United States)

    Gual-Frau, Josep; Abad, Carlos; Amengual, María J; Hannaoui, Naim; Checa, Miguel A; Ribas-Maynou, Jordi; Lozano, Iris; Nikolaou, Alexandros; Benet, Jordi; García-Peiró, Agustín; Prats, Juan

    2015-09-01

    Infertile males with varicocele have the highest percentage of sperm cells with damaged DNA, compared to other infertile groups. Antioxidant treatment is known to enhance the integrity of sperm DNA; however, there are no data on the effects in varicocele patients. We thus investigated the potential benefits of antioxidant treatment specifically in grade I varicocele males. Twenty infertile patients with grade I varicocele were given multivitamins (1500 mg L-Carnitine, 60 mg vitamin C, 20 mg coenzyme Q10, 10 mg vitamin E, 200 μg vitamin B9, 1 μg vitamin B12, 10 mg zinc, 50 μg selenium) daily for three months. Semen parameters including total sperm count, concentration, progressive motility, vitality, and morphology were determined before and after treatment. In addition, sperm DNA fragmentation and the amount of highly degraded sperm cells were analyzed by Sperm Chromatin Dispersion. After treatment, patients showed an average relative reduction of 22.1% in sperm DNA fragmentation (p = 0.02) and had 31.3% fewer highly degraded sperm cells (p = 0.07). Total numbers of sperm cells were increased (p = 0.04), but other semen parameters were unaffected. These data suggest that sperm DNA integrity in grade I varicocele patients may be improved by oral antioxidant treatment.

  14. Female Infertility

    Science.gov (United States)

    Infertility means not being able to get pregnant after at least one year of trying (or 6 ... woman keeps having miscarriages, it is also called infertility. Female infertility can result from age, physical problems, ...

  15. Infertility FAQ's

    Science.gov (United States)

    ... 3286 After hours (404) 639-2888 Contact Media Infertility FAQs Recommend on Facebook Tweet Share Compartir Frequently Asked Questions What is infertility? In general, infertility is defined as not being ...

  16. The application of in vitro maturation of oocytes in the infertile patients with polycystic ovarian syndrome

    Institute of Scientific and Technical Information of China (English)

    Ye Bi-lu; Chen Ya; Zhao Jun-zhao; Ge Hong-shan; Lin Jin-ju

    2005-01-01

    Objective: To evaluate the effects of in vitro maturation (IVM) of oocytes in the infertile patients with polycystic ovarian syndrome(PCOS).Methods:The infertile patients with PCOS who underwent IVM or IVF/ICSI from January 2004 to August 2005 were studied retrospectively. 68 unstimulated cycles (48 cases) underwent IVM as IVM group, 42 cycles (39 cases) underwent IVF/ICSI as control group. Main outcomes including the number of oocytes retrival, the rates of fertilization, embryo cleavage, implantation, pregnancy, miscarriage, ovarian hyperstimulation syndrome (OHSS) and multiple pregnancy were assessed. Results: No FSH was administered in IVM group and the mean number of FSH used was (25±6.2) ampoules in control group. When compared with control group, women in IVM group had significant increase in fertilization rate (70.7% versus 63.9%) and decrease in cleavage rate (87.9% versus 99.4%) and ovarian hyperstimulation syndrome (0 versus 7.1%). No significant differences between IVM group and control group were found in the number of oocytes obtained, implantation rate, clinical pregnancy rate, miscarriage rate and multiple pregnancy rate.Conclusion:Our results suggested that for infertile PCOS women who required assisted conception treatment, IVM is a more economical method with less OHSS complication than that of conventional IVF treatment.

  17. Substantial prevalence of microdeletions of the Y-chromosome in infertile men with idiopathic azoospermia and oligozoospermia detected using a sequence-tagged site-based mapping strategy

    Energy Technology Data Exchange (ETDEWEB)

    Najmabadi, H.; Huang, V.; Bhasin, D. [Drew Univ. of Medicine and Science, Los Angeles, CA (United States)] [and others

    1996-04-01

    Genes on the long arm of Y (Yq), particularly within interval 6, are believed to play a critical role in human spermatogenesis. Cytogenetically detectable deletions of this region are associated with azoospermia in men, but are relatively uncommon. The objective of this study was to validate a sequence-tagged site (STS)-mapping strategy for the detection of Yq microdeletions and to use this method to determine the proportion of men with idiopathic azoospermia or severe oligozoospermia who carry microdeletions in Yq. STS mapping of a sufficiently large sample of infertile men should also help further localize the putative gene(s) involved in the pathogenesis of male infertility. Genomic DNA was extracted from peripheral leukocytes of 16 normal fertile men, 7 normal fertile women, 60 infertile men, and 15 patients with the X-linked disorder, ichthyosis. PCR primers were synthesized for 26 STSs that span Yq interval 6. None of the 16 normal men of known fertility had microdeletions. Seven normal fertile women failed to amplify any of the 26 STSs, providing evidence of their Y specificity. No microdeletions were detected in any of the 15 patients with ichthyosis. Of the 60 infertile men typed with 26 STSs, 11 (18%; 10 azoospermic and 1 oligozoospermic) failed to amplify 1 or more STS. Interestingly, 4 of the 11 patients had microdeletions in a region that is outside the Yq region from which the DAZ (deleted in azoospermia gene region) gene was cloned. In an additional 3 patients, microdeletions were present both inside and outside the DAZ region. The physical locations of these microdeletions provide further support for the concept that a gene(s) on Yq deletion interval 6 plays an important role in spermatogenesis. The presence of deletions that do not overlap with the DAZ region suggests that genes other than the DAZ gene may also be implicated in the pathogenesis of some subsets of male infertility. 48 refs., 2 figs., 2 tabs.

  18. Genetic variation of the E-cadherin gene is associated with primary infertility in patients with ovarian endometriosis.

    Science.gov (United States)

    Kang, Shan; Li, Yan; Li, Bin; Wang, Na; Zhou, Rong-Miao; Zhao, Xi-Wa

    2014-10-01

    To explore the association between the genetic variant of E-cadherin gene and endometriosis-related infertility. Case-control study. University hospital. Five hundred eighty-nine women with ovarian endometriosis including 127 patients with primary infertility and 589 female controls in northern China. None. Single nucleotide polymorphisms (SNPs) in the promoter region, exons, and the 3' untranslated region of the E-cadherin gene were identified by direct sequencing in patients with ovarian endometriosis and with polymerase chain reaction (PCR). Six candidate SNPs (rs16260, rs28372783, rs1801552, rs1801026, rs8049282, and rs13689) were genotyped by PCR and ligase detection reaction. The results revealed a significant association of rs8049282 SNP on E-cadherin gene with endometriosis-related infertility. When compared with control women or endometriosis patients who had a history of successful fertility, the CC genotype of rs8049282 may significantly increase the risk of primary infertility in patients with ovarian endometriosis (adjusted odds ratio [OR] = 2.70, 95% confidence interval [CI] 1.45-5.00; OR = 2.54, 95% CI 1.45-4.44, respectively). Our results suggested that genetic variants on the E-cadherin gene may be involved in endometriosis-related infertility. The rs8049282 SNP of the E-cadherin gene may be a potential molecular marker for the development of primary infertility in northern Chinese women with ovarian endometriosis. Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  19. High risk genetic factor in Chinese patients with idiopathic male infertility:deletion of DAZ gene copy on Y chromosome

    Institute of Scientific and Technical Information of China (English)

    杨元; 肖翠英; 张思仲; 张思孝; 黄明孔; 林立

    2004-01-01

    @@ Idiopathic azoospermia or oligozoospermia affects approximately 2%-4% of all married males. Recently studies have confirmed that the deletion of DAZ in AZFc region of Y chromosome may be one of the important genetic aetiologies of Caucasian male infertility. To determine the relationship between DAZ gene deletion and idiopathic male infertility in Chinese population, we analysed the DAZ gene copy number of AZFc region in patients with idiopathic azoospermia or oligozoospermia, as well as fertile Chinese men.

  20. The Study of Ovarian Artery Hemodynamics in Patients with Infertility by Color Doppler Energy

    Institute of Scientific and Technical Information of China (English)

    肖先桃; 乐桂蓉; 张友耿; 黎春蕾

    2001-01-01

    Seventy-four cases of infertility were examined to study the hemodynamics of the bilateral ovarian arteries at 21st day during the corpus luteum phase by color Doppler energy(CDE) and color Doppler flow imaging (CDFI). All the patients were verified by laparoscopy, fallopian tube patency examination and ovarian function test. Twenty-two healthy women served as controls. The results showed that the difference of resistance index(RI)and pulsatility index (PI) of bilateral ovarian arteries between the infertility and the normal controls had statistical significance (P<0.01), and the PI showed negative correlation with the thickness of endometrium (left side: r=0.724, P<0.01; right side: r=0.756, P<0.01). The results also showed that CDE was more sensitive than CDFI in displaying the ovarian arteries. It could be concluded that the elevated resistance of ovarian artery during the corpus luteum phase was one of the important factors that resulted in infertility.

  1. Evaluation of germ-cell kinetics in infertile patients with proliferating cell nuclear antigen proliferating index

    Institute of Scientific and Technical Information of China (English)

    Li ZENG; Xiang-Tian KONG; Jin-Wei SU; Tong-Li XIA; Yan-Qun NA; Ying-Lu GUO

    2001-01-01

    To explore the usefulness of proliferating cell nuclear antigen proliferating index (PCNA PI) in the pathological diagnosis and treatment of male infertility. Methods: Testicular biopsy specimen obtained from 48 cases of male infertility and 2 normal controls were fixed and embedded. The sections were stained with anti-PCNA monoclonal antibodies or haematoxylin/eosin. Proliferating index (PI), expressed as the percentage of germ-cell nuclei positively stained with PCNA antibody, was assessed from more than 20 seminiferous tubules or 600 germ-cells. Results: The infertile patients were divided into 4 groups: Group 1, normal spermatogenesis ( 14 cases); Group 2, hypospermatogenesis (16 cases); Group 3, germinal arrest (10 cases); Group 4, Sertoli cell only syndrome (8 cases). The PCNA PI of normal control testis was 86.5% (mean value). Group 3 had a significantly lower PCNA PI (29.8%) than normal testis; Group 1 and 2 had similar Pis (82.3% and 82.3%, respectively) as the control testis. PI of the negative control (Group 4) was 0 as no germ-cells were found. Conclusion: PCNA PI is useful for assessing germ-cell kinetics, especially for pathological diagnosis of germinal arrest which is difficult to differentiate by routine HE staining technique. In germinal arrest, there is a significantly lowered PCNA PI, which is an indication of DNA synthesis deterioration, suggesting the use of therapies be different from those for hypospermatogenesis.

  2. A phytotherapic approach to reduce sperm DNA fragmentation in patients with male infertility.

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    Capece, Marco; Romeo, Giuseppe; Ruffo, Antonio; Romis, Leo; Mordente, Salvatore; Di Lauro, Giovanni

    2017-04-28

    Infertility affects 50 to 80 million (between 8 and 12% of couples). Male factor is a cause of infertility in almost half of the cases, mainly due to oligoasthenoteratozoospermia. DNA fragmentation is now considered an important factor in the aetiology of male infertility. We studied the effects on semen analysis and on DNA fragmentation of in vivo admnistration of Myo-Inositol and Tribulus Terrestris plus Alga Ecklonia plus Biovis (Tradafertil; Tradapharma Sagl, Swizerland) in men with previously diagnosed male infertility. Sixty patients were enrolled in the present study and were randomized into two subgroups: the group A who received Myo-inositol 1000 mg, Tribulus Terrestris 300 mg, Alga Ecklonia Bicyclis 200 mg and Biovis one tablet a day for 90 days, and the group B (placebo group) who received one placebo tablet a day for 90 days. The primary efficacy outcome was the improvement of semen characteristics after 3 months' therapy and the secondary outcome was the reduction of the DNA fragmentation after treatment. The groups were homogenous for age, hormonal levels, sperm concentration and all parameters of sperm analysis. Sperm concentration and progressive motility improved after treatment with Tradafertil (3.82 Mil/ml vs. 1.71 Mil/ml; p<0.05; 4.86% vs. 1.00%; p<0.05) as well as the DNA fragmentation (-1.64% vs -0.39%, p<0.001). No side effects were revealed. In conclusion, we can affirm that Tradafertil is safe and tolerable. It is a new phytotherapic approach to Oligoasthenoteratospermia (OAT) syndrome that could lead to good results without interacting with hypothalamic-pituitary-gonadal axis.

  3. Role of diagnostic hystero-laparoscopy in the evaluation of infertility: A retrospective study of 300 patients

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    Prasanta K Nayak

    2013-01-01

    Full Text Available Objective: To determine the role of diagnostic hysterolaparoscopy in the evaluation of infertility in tertiary care centres. Materials and Methods: This retrospective study was conducted at two tertiary care centres (the infertility clinics of Sriram Chandra Bhanj Medical College and Prachi hospital at Cuttack, Odisha throughout the year in 2008. Women aged 20-40 years with normal hormone profile without male factor infertility were included. Results: Out of 300 cases, 206 (69% patients had primary infertility. While laparoscopy detected abnormalities in 34% of the cases, significant hysteroscopy findings were noted in 18% of cases. Together, diagnostic hysterolaparoscopy detected abnormalities in 26% of the infertile patients in both groups. While the most common laparoscopic abnormality was endometriosis (14% and adnexal adhesion (12% in primary and secondary infertile patients, respectively, hysteroscopy found intrauterine septum as the most common abnormality in both groups. Conclusions: Hysterolaparoscopy is an effective diagnostic tool for evaluation of certain significant and correctable tubo-peritoneal and intrauterine pathologies like peritoneal endometriosis, adnexal adhesions, and subseptate uterus, which are usually missed by other imaging modalities.

  4. Infertility with Testicular Cancer.

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    Ostrowski, Kevin A; Walsh, Thomas J

    2015-08-01

    Testicular germ cell cancer is one of the most curable cancers. Most patients are treated during their reproductive years, making infertility a significant quality of life issue after successful treatment. This focused review evaluates the factors that contribute to infertility and specific fertility risks with the various testicular cancer treatments. Timing of patient discussions and current fertility treatments are reviewed.

  5. Office hysteroscopy, transvaginal ultrasound and endometrial histology: a comparison in infertile patients

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    Devleta Balić

    2011-05-01

    Full Text Available Objective. To evaluate accuracy of transvaginal sonography (TVS and hysteroscopy in detection of intrauterine pathology in infertile women. Subjects and methods. This retrospective study was conducted in 56 infertile women with abnormal transvaginal ultrasound findings of the uterine cavity which was performed during the midfollicular phase as a part of routine infertility workup. Hysteroscopy was performed between 6th and 10th day of cycle. Results. The mean age of the subjects was 31.9±4.0. The most frequent ultrasound finding was endometrial polyp in 34 (60.7% patients, septate uterus in 8 (14.3% patients, submucosal myoma in 7 (12.5% patients, endometrial hyperplasia in 5 (8.9% patients and Syndroma Ascherman in 2 (3.6% patients. Hysteroscopy confirmed 20 (35.7% polyps, the same number of myomas, septate uterus and Syndroma Ascherman as detected by ultrasound, (7 (12.5%, 8 (14.3% and 2 (3.6%, respectively and 19 (33.9% endometrial hyperplasia. In 46 women with histological excamination, the sensitivity of TVS and hysteroscopy in the diagnosis of endometrial polyps were identical - 100%, while the specificity was higher in hysteroscopy than in TVS (92.3% versus 56.4%, p<0.001. The sensitivity of TVS in the diagnosis of endometrial hyperplasia was higher than that of hysteroscopy (86.4% versus 22.7%, p<0.001, while specificity was identical, of 100%. Accordance between hysteroscopy and histology was good (k=0.79, between ultrasound and histology was moderete (k=0.59. Conclusion. Hysteroscopy appeared to be more reliable in diagnosis than TVS. The use of a high frequency ultrasound probe leads us to a lack of diagnostic clarity between endometrial polyps and hyperplasia.

  6. Combined letrozole and clomiphene versus letrozole and clomiphene alone in infertile patients with polycystic ovary syndrome

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    Hajishafiha M

    2013-12-01

    Full Text Available Masomeh Hajishafiha,1 Meisam Dehghan,2 Nazila Kiarang,1 Nahideh Sadegh-Asadi,1 Seyed Navid Shayegh,3 Mohammad Ghasemi-Rad2 1Department of Gynecology, Reproductive Health Research Center, Urmia University of Medical Sciences, 2Urmia University of Medical Sciences, 3Gulf Medical University, Ajman, United Arab Emirates Background: Polycystic ovary syndrome (PCOS is the most common endocrine disorder in women of childbearing age (6.8%–18%, is among the most common causes of infertility due to ovulation factors, and accounts for 55%–70% of infertility cases caused by chronic anovulation. In this study, we used a combination of letrozole and clomiphene in patients resistant to both drugs individually, and studied the effects of this combination in ovulation and pregnancy in resistant PCOS patients. Methods: The study population included infertile couples diagnosed as PCOS in the wife. The women used clomiphene for at least six cycles in order to ovulate after failure to form the dominant follicle, and were then put on letrozole for four cycles. Patients who were unable to form the dominant follicle were enrolled on letrozole and clomiphene combination therapy. Results: One hundred enrolled patients underwent 257 cycles of a combination of letrozole and clomiphene, in which 213 were able to form the dominant follicle (82.9% and 44 were unable to do so (17.1%. The number of mature follicles was 2.3±1.1. The mean endometrial thickness in patients on the day of human chorionic gonadotropin administration was 8.17±1.3 mm. The pregnancy rate was 42%. Conclusion: According to the results of this study, it can be proposed that in PCOS patients resistant to clomiphene and letrozole used as single agents, a combination of the two drugs can be administered before using more aggressive treatment that may have severe complications or surgery. This combination may also be used as a first-line therapy to induce ovulation in severe cases of PCOS in order to

  7. Hysterosalpingography in Infertility

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    Masuda Islam Khan

    2014-01-01

    Full Text Available Background: Infertility is a common medical problem. It can be due to problems in either partner, or both. Ovulatory dysfunction, tubal and peritoneal factors comprise the majority of female factor for infertility. Hysterosalpingography (HSG plays an important role in the evaluation of abnormalities related to the uterus and fallopian tubes. Objective: The aim of this study was to evaluate the hysterosalpingographic findings of women with infertility in our setting. Materials and method: This cross sectional study was carried out in the infertility centre at BIRDEM, Dhaka, Bangladesh during the period of September 2002 to February 2003. Out of 100 infertile patients 50 infertile women of reproductive age (21-40 years indicated for HSG were enrolled in this study. Results: Sixty percent patients had secondary infertility. Majority of the subjects of both primary and secondary infertility (55% and 60% were in 26-30 years age group. On HSG any sort of uterine pathology was found in 10% cases and unilateral and bilateral tubal block were present in 24% and 20% cases respectively. Conclusion: Hysterosalpingography, a safe, less invasive procedure, has an important role in diagnosing uterine and tubal factors of infertility.

  8. Cryopreservation of very low numbers of spermatozoa from male patients undergoing infertility treatment using agarose capsules.

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    Hatakeyama, Shota; Tokuoka, Susumu; Abe, Hiroyuki; Araki, Yasuyuki; Araki, Yasuhisa

    2017-07-01

    This study tried to cryopreserve low numbers of spermatozoa from men undergoing infertility treatments by inserting into agarose capsules. The capsules were transferred into a drop of cryoprotectant solution and injected 3-4 motile spermatozoa that were selected by the swim-up method by conventional intracytoplasmic sperm injection. These capsules were put on a Cryotop(®) and frozen in liquid nitrogen vapor, and then submerged into liquid nitrogen and subsequently thawed and recovered. The motile spermatozoa in the capsules were counted. Eventually, we cryopreserved 2142 motile spermatozoa in 702 agarose capsules from 26 male patients and 1356 (63%) spermatozoa maintained their motility after thawing. The spermatozoa motility rates after thawing (MRAT) ranged from 20.0% (5/25) to 95.1% (58/61) among patients. The median MRAT was 68.3% (interquartile range 46.1-75.7). The total number of motile spermatozoa collected by swim-up method strongly correlated with MRAT (r = 0.746). It was possible to cryopreserve spermatozoa from male patients undergoing infertility treatment using agarose capsules. However, there were wide differences in MRAT among patients. It seems the spermatozoa from semen where there were many motile spermatozoa may have higher freezing resistance. Further studies using this method in cryptozoospermic semen, testicular and epididymal spermatozoa are required.

  9. Influence of spermatogenic profile and meiotic abnormalities on reproductive outcome of infertile patients.

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    Barri, Pedro N; Vendrell, Jose M; Martinez, Francisca; Coroleu, Buenaventura; Arán, Begoña; Veiga, Anna

    2005-06-01

    Genetic aspects of male infertility and the possible risks of new assisted reproduction and their influence on the development of zygotes and children born after intracytoplasmic sperm injection (ICSI) need further research. These patients have an increased risk of diploidy, and disomies are frequent in their spermatozoa. Meiotic disorders are more common in testicular biopsies of patients with severe oligoasthenozoospermia. For these reasons, a detailed andrological study is absolutely mandatory before accepting a couple with these characteristics into an IVF-ICSI programme. When an andrological patient has plasma FSH values >10 IU/l and/or very low total motile sperm count meiotic study in order to rule out meiotic arrest or synaptic anomalies. Another important aspect to be considered is the possible benefit of applying preimplantation genetic diagnosis in these cases because they normally have a high percentage of chromosomally abnormal embryos, although in the present study this was not evident. All studies agree on the necessity of conducting follow-up studies in the population of children born after IVF-ICSI. In this way, it will be possible to find out if these infertile patients and their offspring have a higher risk of suffering epigenetic errors and imprinting disorders.

  10. Study of correlation of thyroid profile and clinical parameters in patients with infertility

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    Kameswaramma K.

    2016-05-01

    Conclusions: Every infertile woman with ovulatory dysfunction should also investigated thyroid profile along with other investigations, to open better prospects for such desperate infertile women. [Int J Reprod Contracept Obstet Gynecol 2016; 5(5.000: 1410-1413

  11. N-acetyltransferase 2 (NAT2 Gene Polymorphisms and the Effectiveness of Infertility Treatment in Patients with Peritoneal Endometriosis

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    Ekaterina D. Dubinskaya

    2014-03-01

    Full Text Available Today, infertility has become a global issue. WHO ranks it the fifth among the major diseases of those below 60 years, after alcoholism, depression, injuries and eyesight disorders. Numerous studies conducted on the problems of infertility in endometriosis still do not offer clear answers regarding the pathogenesis and mechanisms of this disease and its influences on fertility. According to the survey results, point mutations of the NAT2 gene (NAT2*5 and NAT2*6 have been identified in 75.6% of the patients with infertility problems and the peritoneal form of endometriosis, that create “slow” allelic variants, which exceed the average index in the population. The peculiarities of the NAT2 gene polymorphisms have been proven to be associated with the effectiveness of the infertility treatment of female patients with peritoneal endometriosis. In the group of non-pregnant patients, the presence of с.341Т>C, c.481C>T, c.590G>A and c.803A>G heterozygous point mutations are 73.2, 73.2, 5.4, and 62.5%, respectively. The significant difference in the comparison of the allelic polymorphism during the various stages of the endometriosis was not identified. At stage III-IV endometriosis the frequency of three and more point substitutions was significantly higher. NAT2 gene polymorphisms can find use as an additional criterion for predicting the effectiveness of the infertility treatment of patients with peritoneal endometriosis.

  12. Is Coasting Valuable in All Patients with Any Cause of Infertility?

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    Tahereh Madani

    2016-11-01

    Full Text Available Objectives: This study aimed to assess the influence of coasting duration on the number and quality of oocytes and fertilization rate in male factor infertile women and those with polycystic ovary syndrome (PCOS. Methods: In this prospective observational follow-up study, 114 patients undergoing coasting (53 women with male factor infertility and 61 women with PCOS were evaluated at the Royan Institute Research Center, Iran, between 2010 and 2012. Results: The results were analyzed according to the coasting periods of 1–4 days. In normal females, the number of oocytes retrieved was significantly reduced after the second day (p = 0.004. In addition, a statistically significant drop was observed in the number of metaphase II oocytes and fertilization rate after the third day (p = 0.006 and p = 0.006, respectively. No significant differences were observed in the number and quality of oocytes retrieved and fertilization rate with regard to coasting days in PCOS patients. Conclusion: Coasting with duration of more than three days should be performed with caution in normal females who are at risk of developing ovarian hyperstimulation syndrome.

  13. Is Coasting Valuable in All Patients with Any Cause of Infertility?

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    Madani, Tahereh; Jahangiri, Nadia; Eftekhari-Yazdi, Poopak; Ashrafi, Mahnaz; Akhoond, Mohammadreza

    2016-01-01

    Objectives This study aimed to assess the influence of coasting duration on the number and quality of oocytes and fertilization rate in male factor infertile women and those with polycystic ovary syndrome (PCOS). Methods In this prospective observational follow-up study, 114 patients undergoing coasting (53 women with male factor infertility and 61 women with PCOS) were evaluated at the Royan Institute Research Center, Iran, between 2010 and 2012. Results The results were analyzed according to the coasting periods of 1–4 days. In normal females, the number of oocytes retrieved was significantly reduced after the second day (p = 0.004). In addition, a statistically significant drop was observed in the number of metaphase II oocytes and fertilization rate after the third day (p = 0.006 and p = 0.006, respectively). No significant differences were observed in the number and quality of oocytes retrieved and fertilization rate with regard to coasting days in PCOS patients. Conclusion Coasting with duration of more than three days should be performed with caution in normal females who are at risk of developing ovarian hyperstimulation syndrome. PMID:27974954

  14. Treating Infertility

    Science.gov (United States)

    ... by a number of factors. Both male and female factors can contribute to infertility. What treatment options are available for infertility? Treatment ... problems. A common problem that leads to male infertility, varicocele , sometimes can be ... are hormonal problems treated in women? Abnormal levels of hormones ...

  15. Investigating the Relationships among Stressors, Stress Level, and Mental Symptoms for Infertile Patients: A Structural Equation Modeling Approach.

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    Jong-Yi Wang

    Full Text Available Patients with infertility are a high risk group in depression and anxiety. However, an existing theoretically and empirically validated model of stressors, stress, and mental symptoms specific for infertile patients is still a void. This study aimed to determine the related factors and their relational structures that affect the level of depressive and anxiety symptoms among infertile patients.A cross-sectional sample of 400 infertility outpatients seeking reproduction treatments in three teaching hospitals across Taiwan participated in the structured questionnaire survey in 2011. The hypothesized model comprising 10 latent variables was tested by Structural Equation Modeling using AMOS 17.Goodness-of-fit indexes, including χ2/DF = 1.871, PGFI = 0.746, PNFI = 0.764, and others, confirmed the modified model fit the data well. Marital stressor, importance of children, guilt-and-blame, and social stressor showed a direct effect on perceived stress. Instead of being a factor of stress, social support was directly and positively related to self-esteem. Perceived stress and self-esteem were the two major mediators for the relationships between stressors and mental symptoms. Increase in social support and self-esteem led to decrease in mental symptoms among the infertile patients.The relational structures were identified and named as the Stressors Stress Symptoms Model, clinically applied to predict anxiety and depression from various stressors. Assessing sources and level of infertility-related stress and implementing culturally-sensitive counseling with an emphasis on positive personal value may assist in preventing the severity of depression and anxiety.

  16. Efficacy of aphrodisiac plants towards improvement in semen quality and motility in infertile males.

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    Mahajan, Ghanashyam Keshav; Mahajan, Arun Yashwant; Mahajan, Raghunath Totaram

    2012-02-17

    Infertility is the inability to conceive after one year of unprotected intercourse. In the present study, herbal composition prepared by using medicinal plants having aphrodisiac potentials was administered orally to the albino rats for 40 days and to the oligospermic patients for 90 days in order to prove the efficacy of herbal composition. Herbal composition was the mixture (powder form) of the medicinal plants namely, Mucuna pruriens (Linn), Chlorophytum borivillianum (Sant and Fernand), and Eulophia campestris (Wall). In the neem oil treated albino rats, there was significant reduction in almost all the parameters viz. body weight, testes and epididymes weight, sperm density and motility, serum levels of testosterone, FSH, and LH compared with control rats. Treatment with said herbal composition for 40 days results significant increased in the body weight, testis, and epididymes weight in rats. Concomitantly the sperm motility and the sperm density were significantly increased. After 90 days of treatment with this herbal composition, sperm density vis-a-vis motility was increased in oligozoospermic patients as a result of elevation in serum testosterone levels. No side effects were noticed during the entire duration of the trial.

  17. Ulipristal Acetate in Myomectomy Optimization in an Infertile Patient with Giant Myomas

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    Elena de la Fuente

    2016-01-01

    Full Text Available The use of ulipristal acetate (UPA has been recently introduced in the treatment of uterine leiomyomas. This drug has proven useful to control menometrorrhagia and to reduce myoma size. In the case presented here, we show the benefits of UPA treatment in facilitating surgical removal of giant myomas in an infertile patient. In addition to myoma reduction and a better control of preoperative bleeding, the treatment with UPA reduced the duration and complexity of the surgery, as well as the area of uterine wall involved and the resulting scar. No side effects were observed and the patient became pregnant 6 months after the surgery and had a normal pregnancy and delivery. This case report shows the beneficial effects of UPA in the preoperative treatment of myomas which affect uterus function.

  18. The role of impairment of adrenal mineraloglucocorticoid function in the development of infertility in varicocele patients.

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    Mazo, E B; Koryakin, M V; Kudryavtsev JuV; Evseev, L P; Akopyan, A S

    1989-01-01

    The study was aimed at the understanding of pathophysiological mechanisms of the impairment of spermatogenesis in varicocele patients. The crucial role of tension increase in the venous plexus of the spermatic cord in spermatogenesis damage in the testis on the varicocele side and absence of any effect of haemodynamic abnormalities on spermatogenesis in the complementary testis has been determined. Retrograde blood flow through the central vein of the left adrenal gland in varicocele has been evidenced by X-ray examination. The role of this phenomenon in the changes of functional activity of the adrenal gland is discussed. Results of the study of functional status of adrenal glands revealed their tendency to provide hyperactivity in synthesis of mineraloglucocorticoids. Correlation between cortisol level in peripheral blood and percentage of abnormal sperm in ejaculate was shown. This fact supported the idea about the existence of a causal interrelationship between abnormalities in the functional status of adrenal glands and development of infertility in varicocele patients.

  19. CHANGES OF SOLUBLE FAS AND SOLUBLE FAS LIGAND IN SERUM AND PERITONEAL FLUID OF INFERTILE PATIENTS WITH ENDOMETRIOSIS

    Institute of Scientific and Technical Information of China (English)

    令狐华; 徐小蓉; 骆建云; 庄琳

    2004-01-01

    Objective To evaluate the relationship between levels of soluble Fas (sFas) and soluble Fas ligand (sFasL) in serum and peritoneal fluid of endometriosis-associated infertility.Methods The soluble Fas ligand and soluble Fas levels in serum and peritoneal fluid of 20infertile patients with endometriosis were assessed with enzyme-linked immunosorbent assay, and were compared with 14 infertile patients due to chronic pelvic infectious disease and 16 fertile controls. Results The sFasL levels were significantly higher in infertile patients with endometriosis (175.09 ±80.55 pg/mL in serum and 284.50 ± 152.38 pg/mL in peritoneal fluid) than those of infertile controls (88.47±43.55 pg/mL in serum and 17.30±9.62 pg/mL in peritoneal fluid) and fertile controls (16.13 ±11.75 pg/mL in serum and 8.84 ± 2.31 pg/mL in peritoneal fluid). In contrast, as for the sFas levels, infertile patients with endometriosis (828.60±429.65 pg/mL in serum and 349.61 ±288.89 pg/mL in peritoneal fluid) did not show any significant difference compared with those in infertile patients resulting from pelvic infectious disease (868.75 ± 570.48 pg/mL in serum and 181.76 ± 157.78 pg/mL in peritoneal fluid) and fertile control (822.26± 129.12 pg/mL in serum and 318.42 ± 145.16 pg/mL in peritoneal fluid). Conclusions Based upon these results, high level of sFasL in serum and peritoneal fluid and thus apoptosis mediated by it may be implicated in the mechanism involved in endometriosis-related infertility.

  20. Organizational and functional status of the Y-linked genes and loci in the infertile patients having normal spermiogram.

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    Anju Kumari

    Full Text Available Male fertility is an orchestrated interplay of loci on the Y chromosome with a number of genes from across the other chromosomes. In this context, micro-deletions in the Y chromosome have been correlated with spermatogenic failure often leading to infertility. However, causes of infertility in the patients with the normal spermiogram have remained unclear and therefore pose another level of challenge. In the present study, we analyzed 64 STSs, studied different Y-linked genes and loci and conducted single nucleotide variant (SNV analyses in 31 infertile males with normal spermiogram along with 67 normal fertile males (NFMs to gain an insight into the organization of their Y chromosome. Further, employing quantitative real-time PCR (qPCR, we studied copy number variation of DYZ1 arrays and three genes and mutational status of SRY by direct sequence analyses. STS analyses of the AZFa, b and c regions in these patients showed known and new mutations. Further, copies of DAZ and BPY2 in the patients were found to be affected (p < 0.001 compared to those in NFMs. All the patients had normal copy number of the SRY however its sequence analysis (in silico showed mutations in eight patients. In four of these eight patients, SRY mutations resulted into truncated proteins. Similarly, DYZ1 analysis showed micro-deletions and it's much reduced copy number (p < 0.001 as compared to those in NFMs. Present study in males with unexplained infertility revealed deletions similar to those observed in oligospermic and azoospermic patients. Thus, there are some common but still unknown factors underlying infertility in these patients irrespective of their spermatogenic status. This work is envisaged to augment DNA diagnosis, proving beneficial in the context of in vitro fertilization (IVF and genetic counselling.

  1. Priorities for family building among patients and partners seeking treatment for infertility.

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    Duthie, Elizabeth A; Cooper, Alexandra; Davis, Joseph B; Sandlow, Jay; Schoyer, Katherine D; Strawn, Estil; Flynn, Kathryn E

    2017-04-05

    Infertility treatment decisions require people to balance multiple priorities. Within couples, partners must also negotiate priorities with one another. In this study, we assessed the family-building priorities of couples prior to their first consultations with a reproductive specialist. Participants were couples who had upcoming first consultations with a reproductive specialist (N = 59 couples (59 women; 59 men)). Prior to the consultation, couples separately completed the Family-Building Priorities Tool, which tasked them with ranking from least to most important 10 factors associated with family building. We describe the highest (top three) and lowest (bottom three) priorities, the alignment of priorities within couples, and test for differences in prioritization between men and women within couples (Wilcoxon signed rank test). Maintaining a close and satisfying relationship with one's partner was ranked as a high priority by majorities of men and women, and in 25% of couples, both partners ranked this factor as their most important priority for family building. Majorities of men and women also ranked building a family in a way that does not make infertility obvious to others as a low priority, and in 27% of couples, both partners ranked this factor as the least important priority for family building. There were also differences within couples that involved either men or women ranking a particular goal more highly than their partners. More women ranked two factors higher than did their partners: 1) that I become a parent one way or another (p = 0.015) and 2) that I have a child in the next year or two (p building paths should be aware that: (1) patients balance multiple priorities as a part of, or beside, becoming a parent; and (2) patients and their partners may not be aligned in their prioritization of achieving parenthood. For infertility patients who are in relationships, clinicians should encourage the active participation of both partners as

  2. Correlation between Seminal Fluid Analysis and Levels of Gonadotropins in Serum and Seminal Plasma of Normozoospermic Men and Infertile Patients

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    Muhammad Baqir MR Fakhrildin

    2007-01-01

    Full Text Available Background: Levels of serum gonadotropins have direct effects on testicular functions and spermatogenesis. Assessment of levels of serum gonadotropins from fathered subjects and infertile patients indicates wide range diversity. In this study, we tried to find out whether the levels of seminal FSH and LH affect the parameters of seminal fluid analysis (SFA and if there is any correlation between levels of serum FSH and LH in healthy men and infertile patients.Materials and Methods: Levels of FSH and LH in serum and seminal plasma were assessed randomly, in addition to examination of seminal fluid analysis from 12 normozoospermic subjects (age range: 33-56 years and 66 infertile patients (age range: 20-62 years with duration of infertility (15-201 months. Macroscopic and microscopic parameters of semen specimens were determined. Data were statistically analyzed using multiple correlation and regression, and MANOVA tests.Results: Result of the present study observed significant positive correlation between FSH levels in serum and seminal plasma (r=0.984; p<0.001 of normozoospermic subjects as compared to other groups of infertile patients. No correlations were noticed between LH levels in serum and seminal plasma of normozoospermic subjects and groups of infertile patients. Significant and positive correlation was assessed between sperm concentration and levels of seminal FSH (r=0.822; p<0.05 and r=0.940; p<0.01 and seminal LH (r=0.989; p<0.001 and r=0.999; p<0.001 of asthenozoospermic and OAT patients respectively. In asthenozoospermic patients, significant and positive correlations were observed between seminal FSH and percentages of sperm motility, progressive motility, sperm normal morphology and total progressive motile sperm/ejaculate.Conclusion: This study shows a strong association and effect between seminal FSH and serum FSH and parameters of SFA for normozoospermic men and different groups of infertile patients. These finding may call

  3. Spontaneous pregnancy after pessary placement in a patient with infertility and advanced pelvic organ prolapse

    Directory of Open Access Journals (Sweden)

    Tsia-Shu Lo

    2016-02-01

    Full Text Available To highlight possible association of advanced pelvic organ prolapse with infertility and its successful outcome following conservative management. We report herein a 38-year-old para 1, non-overweight woman who presented with secondary infertility without any factors for infertility except for an advanced POP. She had intrauterine insemination (IUI performed twice at a local clinic and in vitro fertilization-embryo transfer (IVF-ET program twice in our institute unsuccessfully. She conceived spontaneously after vaginal pessary placement and delivered, vaginally, a healthy female baby weighing 3,365 g at the 38th week of gestation. Advanced POP appears to be an important risk factor for infertility. After completing an infertility workup, pessary application can be the first-line treatment modality for women with unexplained infertility due to advanced POP.

  4. Multiple Determinations of Sperm DNA Fragmentation Show That Varicocelectomy Is Not Indicated for Infertile Patients with Subclinical Varicocele

    Science.gov (United States)

    García-Peiró, Agustín; Ribas-Maynou, Jordi; Oliver-Bonet, María; Navarro, Joaquima; Checa, Miguel A.; Nikolaou, Alexandros; Amengual, María J.; Abad, Carlos; Benet, Jordi

    2014-01-01

    Varicocele is one of the most common causes of low semen quality, which is reflected in high percentages of sperm cells with fragmented DNA. While varicocelectomy is usually performed to ameliorate a patient's fertility, its impact on sperm DNA integrity in the case of subclinical varicocele is poorly documented. In this study, multiple DNA fragmentation analyses (TUNEL, SCD, and SCSA) were performed on semen samples from sixty infertile patients with varicocele (15 clinical varicoceles, 19 clinical varicoceles after surgical treatment, 16 subclinical varicoceles, and 10 subclinical varicoceles after surgical treatment). TUNEL, SCD, and SCSA assays all showed substantial sperm DNA fragmentation levels that were comparable between subclinical and clinical varicocele patients. Importantly, varicocelectomy did improve sperm quality in patients with clinical varicocele; however, this was not the case in patients with subclinical varicocele. In summary, although infertile patients with clinical and subclinical varicocele have similar sperm DNA quality, varicocelectomy should only be advised for patients with clinical varicocele. PMID:24967335

  5. Evaluation of Uterine Biophysical Profile and to Assess its Role in Predicting Conception among Unexplained Primary Infertility Patients

    Directory of Open Access Journals (Sweden)

    Pooja Gupta

    2014-12-01

    Full Text Available Introduction: Infertility is a devastating disease which affects its victims at a very basic level the ability to reproduce. This can be divisive to the couples involved, their relatives and friends. The influence of infertility can be immense. There are a lot of medical and social consequences of infertility and the psychological sequelae are one of them. Affected patients and their families suffer from loss of esteem, disappointment and depression. Considering the immense effect of infertility on the life of not only the affected couples but also on their families and relatives the present study was conducted with following objective. Objective: To evaluate the Uterine Biophysical Profile and to assess its role in predicting the conception outcome in spontaneous cycles in patients with unexplained primary infertility. Material &Methods: A prospective observational study was conducted in the Department of Obstetrics and Gynaecology, U.P. Rural Institute of Medical Sciences & Research, Saifaion 55 women with unexplained primary infertility after standard diagnostic work up. Ultrasound (TVS measurement of all patients was performed in their midcycle of spontaneous cycle. The Uterine Biophysical Profile (UBP i.e. certain sonographic qualities of the uterus were noted during the normal mid-cycle of these patients. These included 7 parameters: Endometrial thickness in greatest AP dimension of 7 mm or greater (full-thickness measurement, a layered ("5 line" appearance to the endometrium, myometrial contractions causing a wave like motion of the endometrium, homogeneous myometrial echogenicity, uterine artery blood flow (as measured by PI, less than 3.0, blood flow within zone 3 using color doppler technique, myometrial blood flow seen on gray-scale examination. The Uterine Scoring System for Reproduction ("USSR" was used to evaluate the total score. Results: Among 55 unexplained primary infertility patients 24 i.e. 43.63% conceived by serial

  6. Preimplantation Genetic Screening: An Effective Testing for Infertile and Repeated Miscarriage Patients?

    Directory of Open Access Journals (Sweden)

    Ning Wang

    2010-01-01

    Full Text Available Aneuploidy in pregnancy is known to increase with advanced maternal age (AMA and associate with repeated implantation failure (RIF, and repeated miscarriage (RM. Preimplantation genetic screening (PGS has been introduced into clinical practice, screening, and eliminating aneuploidy embryos, which can improve the chance of conceptions for infertility cases with poor prognosis. These patients are a good target group to assess the possible benefit of aneuploidy screening. Although practiced widely throughout the world, there still exist some doubts about the efficacy of this technique. Recent randomized trials were not as desirable as we expected, suggesting that PGS needs to be reconsidered. The aim of this review is to discuss the efficacy of PGS.

  7. Multiple Determinations of Sperm DNA Fragmentation Show That Varicocelectomy Is Not Indicated for Infertile Patients with Subclinical Varicocele

    Directory of Open Access Journals (Sweden)

    Agustín García-Peiró

    2014-01-01

    Full Text Available Varicocele is one of the most common causes of low semen quality, which is reflected in high percentages of sperm cells with fragmented DNA. While varicocelectomy is usually performed to ameliorate a patient’s fertility, its impact on sperm DNA integrity in the case of subclinical varicocele is poorly documented. In this study, multiple DNA fragmentation analyses (TUNEL, SCD, and SCSA were performed on semen samples from sixty infertile patients with varicocele (15 clinical varicoceles, 19 clinical varicoceles after surgical treatment, 16 subclinical varicoceles, and 10 subclinical varicoceles after surgical treatment. TUNEL, SCD, and SCSA assays all showed substantial sperm DNA fragmentation levels that were comparable between subclinical and clinical varicocele patients. Importantly, varicocelectomy did improve sperm quality in patients with clinical varicocele; however, this was not the case in patients with subclinical varicocele. In summary, although infertile patients with clinical and subclinical varicocele have similar sperm DNA quality, varicocelectomy should only be advised for patients with clinical varicocele.

  8. Effect of bromocryptine in oligozoospermic men with hyperprolactinaemia.

    Science.gov (United States)

    Krause, W

    1980-01-01

    13 patients with oligozoospermia, showing high prolactin serum levels but no signs of a prolactinoma, were treated with the specific prolactin inhibitor bromocryptine. After a 50 day treatment period an increase of sperm count in 6 cases, a decrease in 2 cases and no alteration in 5 cases was observed. Other semen parameters were not altered. Serum prolactin was significantly lowered. No explanation for the influence of inhibition of prolactin release on spermatogenesis can be given at present. The value of this therapy therefore is doubtful.

  9. Medical Imaging and Infertility.

    Science.gov (United States)

    Peterson, Rebecca

    2016-11-01

    Infertility affects many couples, and medical imaging plays a vital role in its diagnosis and treatment. Radiologic technologists benefit from having a broad understanding of infertility risk factors and causes. This article describes the typical structure and function of the male and female reproductive systems, as well as congenital and acquired conditions that could lead to a couple's inability to conceive. Medical imaging procedures performed for infertility diagnosis are discussed, as well as common interventional options available to patients. © 2016 American Society of Radiologic Technologists.

  10. Dermatoglyphic pattern in male infertility.

    Science.gov (United States)

    Sontakke, B R; Talhar, S; Ingole, I V; Shende, M R; Pal, A K; Bhattacharaya, T

    2013-06-01

    Dermatoglyphics in infertile male patients were studied and compared with that of age matched controls to see whether any specific dermatoglyphic pattern exists in infertile male patients. Infertile male patients with abnormal semen profile were referred to Cytogenetic Laboratory for karyotyping. We selected twenty-four infertile male patients with abnormal semen profile. Out of twenty-four infertile male patients, nineteen were with normal Karyotype and five patients were with abnormal Karyotype. Loop was the commonest pattern observed in the infertile male patients. All these fingertip and palmar dermatoglyphic findings were compared with that of result on finger and palmar dermatoglyphics of equal number of age matched controls. Statistical evaluation was done with software "EPI- info, version-6.04 d". Infertile males had reduced number of loops as compared to that of controls which was statistically significant. Total whorls were increased in infertile male patients as compared to that of controls which was statistically insignificant. Percentage of true palmar pattern in I 3 and I 4 areas was reduced in infertile male patients as compared to that of controls which was statistically insignificant.

  11. Patient centred care in infertility health care: direct and indirect associations with wellbeing during treatment.

    Science.gov (United States)

    Gameiro, Sofia; Canavarro, Maria Cristina; Boivin, Jacky

    2013-12-01

    To investigate whether different dimensions of patient centred care (PCC) were directly associated with wellbeing or indirectly, via lower concerns about medical procedures and/or increased tolerability of treatment. Cross-sectional study with 322 women and 111 men undergoing fertility diagnosis or treatment recruited online and in clinical setting. Participants completed questionnaires that assess PCC (PCQ-Infertility), individual (BSI Anxiety and Depression subscales) and relational wellbeing (FertiQoL Relational Domain), treatment concerns (CART Procedural Concerns scale) and tolerability (FertiQoL Tolerability Domain) and they filled a socio-demographic and fertility data file. All dimensions of PCC were positively associated with better wellbeing except for organization of care. Information provision and continuity of care were indirectly associated with better individual wellbeing, the first via lower treatment concerns and the second via higher treatment tolerability. Competence, accessibility, continuity and communication were indirectly associated with better relational wellbeing via higher treatment tolerability. Patient centred care promotes wellbeing during treatment. PCC is directly associated to wellbeing but also indirectly. The mode of action of the different PCC dimensions on wellbeing varies. To promote patients' wellbeing during treatment clinics should provide treatment related information and allow patients to establish a stable clinical relationship with a trustworthy and competent physician. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  12. Breast Cancer and Infertility

    OpenAIRE

    2015-01-01

    Breast cancer is the most common malignancy among women and may accompany infertility. The relationship between infertility treatment and breast cancer has not yet been proven. However, estrogen exposure is well known to cause breast cancer. Recent advances in treatment options have provided young patients with breast cancer a chance of being mother [Archives Medical Review Journal 2015; 24(3.000): 317-323

  13. Urogenital Tract Infection in Asymptomatic Male Patients with Infertility in University of Benin Teaching Hospital, Benin City, Edo State

    Directory of Open Access Journals (Sweden)

    Ibadin, K. O.

    2012-01-01

    Full Text Available Aims: Urogenital tract infection (UTI contributes to the commonest single defined cause of infertility worldwide. To evaluate the role of urogenital tract infection in male with infertility and its association with sperm quality. Methodology and Results: Three hundred and twenty three (323 samples from infertile male subject were screened microbiologically for microorganisms associated with urogenital tract infection with seventy-two (72 age-matched male as controls using microbiological standard procedure. 164 (50.8% infection rate was recorded. The dorminant uropathogen detected or isolated were Staphylococcus aureus (14.0%, Chlamydia trachomatis (11.4%, Escherichia coli (4.3%, Micoplasma genitalium (4.0% Klebsielli aerogenes (4.0%. Others were Staphylococus saprophyticus, Pseudomonas aeruginosa, Protein mirabilis with 2.7% each respectively, Protein vulgaria treponema pallidum (2.1%, Schistosoma haematobium (0.9% Wulchereria Bancrofti (0.3%, Human immune virus (2.7%. Semen profile of the male patients with urogenital tract infection had abnormal semen quality in this study P<0.05. Conclusion, significance and impact of study: Oligospermic infertile male subjects should be screened for urogenital tract infection to further enhance good quality sperms and functions.

  14. Novel FSHβ mutation in a male patient with isolated FSH deficiency and infertility.

    Science.gov (United States)

    Zheng, Junjie; Mao, Jiangfeng; Cui, Mingxuan; Liu, Zhaoxiang; Wang, Xi; Xiong, Shuyu; Nie, Min; Wu, Xueyan

    2017-06-01

    Isolated follicle stimulating hormone (FSH) deficiency due to mutations in FSHβ is an extremely rare autosomal recessive disease that has only been reported in ten patients to date. Symptoms of the disease include amenorrhoea and hypogonadism in women and azoospermia and normal testosterone levels in men. This study describes a Chinese male patient who presented with cryptorchidism and infertility. His serum hormonal profile revealed low FSH, elevated LH and normal testosterone levels. Sequence analysis identified a novel homozygous mutation in the FSHβ gene (c.343C > T) predicted to result in a premature termination codon and a truncated FSH protein (p.R115X). Both parents were heterozygous carriers of the mutation with normal pubertal development and fertility. The patient's testicular volume increased after one year of exogenous FSH replacement therapy at which point spermatocytes were detected in seminal samples, indicating potential future spermatogenesis. The expanded spectrum of FSHβ mutations and associated clinical manifestations described in this study may improve the diagnosis and treatment of this disease. Copyright © 2017. Published by Elsevier Masson SAS.

  15. Comparison of uterine and tubal pathology identified by transvaginal sonography, hysterosalpingography, and hysteroscopy in female patients with infertility.

    Science.gov (United States)

    Phillips, Catherine H; Benson, Carol B; Ginsburg, Elizabeth S; Frates, Mary C

    2015-01-01

    The causes of female infertility are multifactorial and necessitate comprehensive evaluation including physical examination, hormonal testing, and imaging. Given the associated psychological and financial stress that imaging can cause, infertility patients benefit from a structured and streamlined evaluation. The goal of such a work up is to evaluate the uterus, endometrium, and fallopian tubes for anomalies or abnormalities potentially preventing normal conception. To date, the standard method for assessing these structures typically involves some combination of transvaginal sonography (TVS), hysterosalpingography (HSG), and hysteroscopy (HSC). The goal of this review is to compare the diagnostic accuracy of TVS, HSG, and HSC for diagnosing abnormalities in infertility patients to determine if all studies are necessary for pre-treatment evaluation. We identified infertility patients prior to initiation of assisted reproductive technology who had baseline TVS, HSG, and HSC within 180 days of each other. From medical record review, we compared frequencies of each finding between modalities. Of the 1274 patients who received a baseline TVS over 2 years, 327 had TVS and HSG within 180 days and 55 patients had TVS, HSG and HSC. Of the 327, TVS detected fibroids more often than HSG (74 vs. 5, p < .0001), and adenomyosis more often than HSG (7 vs. 2, p = .02). HSG detected tubal obstruction more often than TVS (56 vs. 8, p = .002). Four (1.2 %) patients had endometrial polyps on both HSG and TVS. In the 55 patients with HSG, TVS, and HSC, HSC identified endometrial polyps more often than TVS (10 vs. 1, p = .0001) and HSG (10 vs. 2, p = .0007). TVS detected more fibroids than HSC (17 vs. 5, p < .0001). Tubal obstruction was identified more often by HSG than HSC (19 vs. 5, p < .0001). TVS is superior for evaluation of myometrial pathology. HSG is superior for evaluation of tubal pathologies. Endometrial pathologies are best identified with

  16. Genetic polymorphisms in glutathione S-transferase T1 affect the surgical outcome of varicocelectomies in infertile patients

    Institute of Scientific and Technical Information of China (English)

    Kentaro Ichioka; Kanji Nagahama; Kazutoshi Okubo; Takeshi Soda; Osamu Ogawa; Hiroyuki Nishiyama

    2009-01-01

    Glutathione S-transferases (GSTs), superoxide dismutase 2 (SOD2) and NAD(P)H:quinone oxidoreductase 1 (NQO1) are anti-oxidant enzyme genes. Polymorphisms of GSTs, SOD2 and NQO1 have been reported to influence individual susceptibility to various diseases. In an earlier study, we obtained preliminary findings that a subset of glutathione S-transferase T1 (GSTT1)-wt patients with varicocele may exhibit good response to varicocelectomy. In this study, we extended the earlier study to determine the distribution of genotype of each gene in the infertile population and to evaluate whether polymorphism of these genes affects the results of surgical treatment of varicocele. We analyzed 72 infertile varicocele patients, 202 infertile patients without varicocele and 101 male controls. Genotypes of GSTs were determined by polymerase chain reaction (PCR). Genotyping of SOD2 and NQO1 was performed using the PCR-restriction fragment length polymorphism (PCR-RFLP) method. A significantly better response to varicocelectomy was found in patients with the GSTTI-wt genotype (63.2%) and NQO1-Ser/Ser genotype (80.0%) than in those with GSTT1-null genotype (35.3%) and NQO1-Pro/Pro or NQO1-Pro/Ser genotype (45.2%), respectively. The frequencies of glutathione S-transferase M1/T1, SOD2 and NQO1 genotypes did not differ significantly among the varicocele patients, idiopathic infertile patients and male controls. GSTT1 genotype is associated with improvement of semen parameters after varicocelectomy. As the number of patients with NQO1-Ser/Ser genotype was not sufficient to reach definite conclusions, the association of NQO1 genotype with varicoceleetomy requires further investigation.

  17. Knowledge, perception and attitude of infertile women in Benin City ...

    African Journals Online (AJOL)

    Knowledge, perception and attitude of infertile women in Benin City, Nigeria to the ... has revolutionalized the management of couples with long standing infertility. ... METHODS: This was a questionnaire based survey of 178 infertile patients ...

  18. [Evaluation of endometriosis fertility index in follow-up treatment of endometriosis combined with infertility patients after laparoscopic surgery].

    Science.gov (United States)

    Qian, R Y; Wu, X; Sheng, J; Zheng, P; Zhou, Q; Duan, A H; Zhang, J P; Zhang, Y L; Lu, D

    2017-04-25

    Objective: To explore the application of endometriosis fertility index (EFI) in guidance after laparoscopic surgery of endometriosis patients combined with infertility and to explore methods to improve pregnancy rate in different EFI groups. Methods: A prospective research was done in endometriosis patients combined with infertility in Beijing Obstetrics and Gynecology Hospital from January 2010 to June 2011, after laparoscopic surgery, these 146 patients were divided into 3 groups by EFI score. Using different pregnancy guidance, these patients had 5 years follow-up. Results: (1) The 5 years overall pregnancy rate was 89.0% (130/146). The pregnancy rate was 95.7% (45/47) in EFI≥9 group, 92.8% (77/83) in EFI 5-8 group and 8/16 in EFI≤4 group, three groups were all reach satisfactory pregnancy rate; the rate of the first two groups had no statistically significance (P=0.498), but had significant difference with the last group (Pinfertility after laparoscopic surgery. EFI score guidance, strict post-operation management and positive pregnancy scheme could significantly improve the pregnancy rate of endometriosis patients with infertility.

  19. REPRODUCTIVE OUTCOME, DURATION OF PREGNANCY AND MODE OF DELIVERY AFTER HYSTEROSCOPIC METROPLASTY IN PATIENTS WITH INFERTILITY

    Directory of Open Access Journals (Sweden)

    Tofoski Gligor

    2016-07-01

    Full Text Available Introduction: Reproductive outcome can be negatively affected in patients with congenital uterine anomalies (CUA, increasing the number of unsuccessful pregnancies and obstetric complications. Standard, safe and minimally invasive method for the treatment of correctible types of congenital uterine anomalies is hysteroscopic metroplasty (HM. The aim of the study was to analyze the reproductive outcome, duration of pregnancy and mode of delivery in group of patients with infertility after hysteroscopic metroplasty. Material and methods: We analyzed 48 patients with previous history of fetal loss (abortion to whom hysteroscopy was done in the period of 01.11.2009 to 01.05.2013 year at the University Clinic of Obstetrics and Gynecology in Skopje. In patients who were diagnosed having CUA hysteroscopic metroplasty was done. Patients and their reproductive outcome were followed for a period of at least 2 years after the intervention. Reproductive outcome was followed considering pregnancy rate, fetal loss (abortion up to 22 gestational week, rates of preterm and term deliveries, live births and mode of delivery. Statistical analysis was performed using computer software and value for the confidence interval (± 95% CI was considered to be statistically significant with level of p<0.05. Results: After hysteroscopic metroplasty, there was a significant decrease of the abortion rate to 13.9%, and significant increase in pregnancy rates of 86.1%. Overall pregnancy rate was 75%, and term delivery was noted in 93,6 % of the patients, with spontaneus deliveries in 58,6 %. There were no complications during the hysteroscopic metroplasty, nor during the deliveries. Conclusion: Hysteroscopic metroplasty has a significant effect on the reproductive outcome, resulting in a large number of live births and no significant complication during consecutive pregnancy and delivery.

  20. Treatment of varicocele infertility men patients of different Chinese medical syndrome types by integrative medicine treatment selection:a primary research

    Institute of Scientific and Technical Information of China (English)

    倪凯

    2013-01-01

    Objective To explore the optimal treatment selection for treating varicocele(VC) male infertility patients accompanied with oligozoospermia or azoospermia of different Chinese medical syndrome types by comparing the efficacies of integrative medicine.Methods One hundred and

  1. The impact of blood and seminal plasma zinc and copper concentrations on spermogram and hormonal changes in infertile Nigerian men.

    Science.gov (United States)

    Akinloye, Oluyemi; Abbiyesuku, Fayeofori M; Oguntibeju, Oluwafemi O; Arowojolu, Ayodele O; Truter, Ernie J

    2011-07-01

    Zinc (Zn) and copper (Cu) concentrations in sera and seminal plasma of 60 infertile males (40 oligozoospermic and 20 azoospermic) and 40 males with evidence of fertility (normozoospermic; controls) were estimated using atomic absorption spectrophotometry. The results were correlated with the subject's spermogram and hormonal levels in order to determine their relationship and significance in male infertility. The mean serum concentration of zinc was significantly (pspermatozoa viability. In conclusion, the measurement of serum Zn level, apart from being a good index of the assessment of prostatic secretion and function, may be considered a useful tool in addition to other parameters in assessing male infertility. Also, a lower Cu/Zn ratio in seminal plasma may serve as a supportive tools in assessing male infertility.

  2. Detection of Y chromosome microdeletions and mitochondrial DNA mutations in male infertility patients.

    Science.gov (United States)

    Güney, A I; Javadova, D; Kırac, D; Ulucan, K; Koc, G; Ergec, D; Tavukcu, H; Tarcan, T

    2012-04-27

    Infertility affects about 10-15% of all couples attempting pregnancy with infertility attributed to the male partner in approximately half of the cases. Proposed causes of male infertility include sperm motility disturbances, Y chromosome microdeletions, chromosomal abnormalities, single gene mutations, and sperm mitochondrial DNA (mtDNA) rearrangements. To investigate the etiology of decreased sperm fertility and motility of sperm and to develop an appropriate therapeutic strategy, the molecular basis of these defects must be elucidated. In this study, we aimed to reveal the relationships between the genetic factors including sperm mtDNA mutations, Y chromosome microdeletions, and sperm parameters that can be regarded as candidate factors for male infertility. Thirty men with a history of infertility and 30 fertile men were recruited to the study. Y chromosome microdeletions were analyzed by multiplex PCR. Mitochondrial genes ATPase6, Cytb, and ND1, were amplified by PCR and then analyzed by direct sequencing. No Y chromosome microdeletions were detected in either group. However, a total of 38 different nucleotide substitutions were identified in the examined mitochondrial genes in both groups, all of which are statistically non-significant. Fifteen substitutions caused an amino acid change and 12 were considered novel mutations. As a conclusion, mtDNA mutations and Y chromosome microdeletions in male infertility should be examined in larger numbers in order to clarify the effect of genetic factors.

  3. Further evidence of the clinical, hormonal, and genetic heterogeneity of Klinefelter syndrome: a study of 216 infertile Egyptian patients.

    Science.gov (United States)

    Abdel-Razic, Moheb M; Abdel-Hamid, Ibrahim A; Elsobky, Ezzat; El-Dahtory, Faeza

    2012-01-01

    This study aims to provide further insight into the phenotypic heterogeneity of Klinefelter syndrome (KS) by presenting clinical, hormonal, and genetic data from a large series of Egyptian infertile patients with KS. A retrospective case series of KS patients was studied over a period from January 2003 to April 2010. All patients underwent a complete history and physical examination; color duplex examination; semen analysis; measurement of total testosterone (T), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and prolactin (PRL); and chromosomal typing. Mosaic KS diagnosis was confirmed by fluorescence in situ hybridization. The series included 216 KS patients (198 nonmosaic, 16 mosaic, and 2 KS variants). Typical clinical signs of hypoandrogenism were observed in 86% of patients. Gynecomastia affected 20.8% of the patients. Eunuchoidal body proportions, with arm span exceeding height and lower segment length exceeding upper segment length, were detected in 43.9% and 64.4% of the patients, respectively. In all patients, a reduction in testicular size and azoospermia were detected. Normal levels of T, FSH, LH, E2, and PRL were detected in 44.5%, 3.7%, 3.3%, 93.5%, and 91.2% of patients, respectively. Differences were not significant between patients with classic KS and those with mosaic KS in terms of the frequency of clinical signs of hypoandrogenism, gynecomastia, low T concentrations, or high concentrations of FSH, LH, E2, and PRL (all P > .05). The results of the current study emphasize the heterogeneous clinical, hormonal, and genetic phenotype of infertile KS patients. Our findings support the usefulness of cytogenetic studies in infertile patients showing small testicular size and azoospermia, regardless of the presence of other clinical or endocrine findings.

  4. Free radical scavenging window of infertile patients with polycystic ovary syndrome: correlation with embryo quality.

    Science.gov (United States)

    Huang, Bo; Li, Zhou; Ren, Xinling; Ai, Jihui; Zhu, Lixia; Jin, Lei

    2017-06-01

    The activity of free radicals in follicular fluid was related to ovarian responsiveness, in vitro fertilization (IVF), and embryo transfer success rate. However, studies analyzing the relationship between the free radical scavenging capacity and embryo quality of infertile women with polycystic ovarian syndrome (PCOS) were lacking. The aim of this study was to evaluate the relationship between the free radical scavenging window of women with PCOS and their embryo quality. The free radical scavenging capacity of follicular fluid from women with PCOS was determined by a,a-diphenyl-b-picrylhydrazyl (DPPH), 2,2-azinobis (3-ethylbenzthiazoline-6-sulphonic acid) assay, superoxide radical, and reactive oxygen species (ROS) assay. In the DPPH and ROS assays, the follicular fluid from grades I and II embryos was significantly higher than the follicular fluid from grades III and IVembryos. The lower control limit of DPPH radical scavenging capacity and upper control limit of ROS level were 13.2% and 109.0 cps, respectively. The calculated lower control limit and upper control limit were further confirmed in the follicular fluid of embryos of all grades. These cut-off values of free radical scavenging activity of follicular fluid could assist embryologists in choosing the development of embryos in PCOS patients undergoing IVF.

  5. Endocrine disorders & female infertility.

    Science.gov (United States)

    Unuane, David; Tournaye, Herman; Velkeniers, Brigitte; Poppe, Kris

    2011-12-01

    Female infertility occurs in about 37% of all infertile couples and ovulatory disorders account for more than half of these. The ovaries are in continuous interaction with the other endocrine organs. The interplay may account for infertility occurring at different levels and may render the diagnosis of infertility a difficult exercise for the involved physician. A hypothalamic cause of female infertility should be considered in an appropriate clinical context, with tests pointing to a hypogonadotropic hypogonadism. It can be functional, physiological or related to organic causes. Hyperprolactinemia has well characterized effects on the normal gonadal function and treatment is well established. Acromegaly and Cushing's disease may impair fertility at different levels, mechanisms involved however remain ill defined. Thyroid disorders, both hyperthyroidism and hypothyroidism, can interact with the ovaries, through a direct effect on ovarian function, but autoimmunity may be involved, as well as alterations of the sex hormone binding protein levels. Primary ovarian disorders, such as the polycystic ovary syndrome and primary ovarian insufficiency are frequent diseases, for which novel treatments are currently being developed and discussed. We will propose an algorithm for the diagnosis and approach of the female patient presenting with infertility on the basis of the available evidence in literature. Copyright © 2011 Elsevier Ltd. All rights reserved.

  6. Extended letrozole regimen versus clomiphene citrate for superovulation in patients with unexplained infertility undergoing intrauterine insemination: a randomized controlled trial.

    Science.gov (United States)

    Fouda, Usama M; Sayed, Ahmed M

    2011-06-21

    The aim of this randomized controlled trial was to compare the efficacy of extended letrozole regimen with clomiphene citrate in women with unexplained infertility undergoing superovulation and intrauterine insemination (IUI). Two hundred and fourteen patients with unexplained infertility were randomized into two equal groups using computer generated list and were treated by either letrozole 2.5 mg/day from cycle day 1 to 9 (extended letrozole group, 211 cycles) or clomiphene citrate 100 mg/day from cycle day 3 to 7 (clomiphene citrate group,210 cycles). Intrauterine insemination was performed 36 to 40 hours after HCG administration. Both groups were comparable with regard to number of mature follicles (2.24 +/- 0.80 Vs 2.13 +/- 0.76) and the day of HCG administration. Serum estradiol was significantly greater in clomiphene citrate group (356 +/- 151 Vs 822 +/- 302 pg/ml, P = superovulation and IUI. ClinicalTrials.gov, NCT01232075.

  7. Extended letrozole regimen versus clomiphene citrate for superovulation in patients with unexplained infertility undergoing intrauterine insemination: A randomized controlled trial

    Directory of Open Access Journals (Sweden)

    Sayed Ahmed M

    2011-06-01

    Full Text Available Abstract Background The aim of this randomized controlled trial was to compare the efficacy of extended letrozole regimen with clomiphene citrate in women with unexplained infertility undergoing superovulation and intrauterine insemination (IUI. Methods Two hundred and fourteen patients with unexplained infertility were randomized into two equal groups using computer generated list and were treated by either letrozole 2.5 mg/day from cycle day 1 to 9 (extended letrozole group, 211 cycles or clomiphene citrate 100 mg/day from cycle day 3 to 7 (clomiphene citrate group,210 cycles. Intrauterine insemination was performed 36 to 40 hours after HCG administration. Results Both groups were comparable with regard to number of mature follicles (2.24 +/- 0.80 Vs 2.13 +/- 0.76 and the day of HCG administration. Serum estradiol was significantly greater in clomiphene citrate group (356 +/- 151 Vs 822 +/- 302 pg/ml, P = Conclusion The extended letrozole regimen had a superior efficacy as compared with clomiphene citrate in patients of unexplained infertility undergoing superovulation and IUI. Trial registration ClinicalTrials.gov, NCT01232075

  8. Understanding Infertility - The Basics

    Science.gov (United States)

    ... Home FAQs Frequently Asked Questions Quick Facts About Infertility FAQs About Infertility FAQs About the Psychological Component of Infertility FAQs About Cloning and Stem Cell Research SART's ...

  9. Sexual Dysfunction and Infertility

    Science.gov (United States)

    ... Home FAQs Frequently Asked Questions Quick Facts About Infertility FAQs About Infertility FAQs About the Psychological Component of Infertility FAQs About Cloning and Stem Cell Research SART's ...

  10. Psychological Component of Infertility

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    ... Home FAQs Frequently Asked Questions Quick Facts About Infertility FAQs About Infertility FAQs About the Psychological Component of Infertility FAQs About Cloning and Stem Cell Research SART's ...

  11. Smoking and Infertility

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    ... Home FAQs Frequently Asked Questions Quick Facts About Infertility FAQs About Infertility FAQs About the Psychological Component of Infertility FAQs About Cloning and Stem Cell Research SART's ...

  12. Ovarian Drilling for Infertility

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    ... Home FAQs Frequently Asked Questions Quick Facts About Infertility FAQs About Infertility FAQs About the Psychological Component of Infertility FAQs About Cloning and Stem Cell Research SART's ...

  13. Stress and Infertility

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    ... Home FAQs Frequently Asked Questions Quick Facts About Infertility FAQs About Infertility FAQs About the Psychological Component of Infertility FAQs About Cloning and Stem Cell Research SART's ...

  14. Seminal vesicles and diabetic neuropathy: ultrasound evaluation in patients with couple infertility and different levels of glycaemic control

    Institute of Scientific and Technical Information of China (English)

    Sandro La Vignera; Rosita A Condorelli; Enzo Vicari; Rosario D'Agata; Aldo E Calogero

    2011-01-01

    The aim of this study was to evaluate the ultrasound characteristics of the seminal vesicles (SVs) of infertile patients with diabetes mellitus (DM) and diabetic neuropathy (DN) and to investigate possible changes in ultrasound characteristics related to glycaemic control.To accomplish this,45 infertile patients with type 2 DM and symptomatic DN were selected.Twenty healthy fertile men and 20 patients with idiopathic oligoasthenoteratozoospermia without DM represented the control groups.DM patients were arbitrarily divided into three groups according to glycaemic control level (A=glycosylated haemoglobin <7%; B=glycosylated haemoglobin between 7% and 10%; C=glycosylated haemoglobin > 10%).Patients underwent prostate-vesicular transrectal ultrasonography and sperm analysis.The following SV ultrasound parameters were recorded:(i) body antero-posterior diameter (APD); (ii) fundus APD; (iii) parietal thicknesses of the right and left SVs; and (iv) the number of polycyclic areas within both SVs.We then calculated the following parameters:(i) fundus/body (F/B) ratio; (ii) difference of the parietal thickness between the right and the left SV; and (iii) pre-and post-ejaculatory APD difference.All DM patients had a higher F/B ratio compared to controls (P<0.05).Group C had a higher F/B ratio compared to the other DM groups (P<0.05).All DM patients had a lower pre-and post-ejaculatory difference of the body SV APD compared to controls (P<0.05).Groups A and B had a similar pre-and post-ejaculatory difference of the body SV APD,whereas this difference was lower in Group C (P<0.05).In conclusion,infertile DM patients with DN showed peculiar SV ultrasound features suggestive of functional atony,and low glycaemic control was associated with greater expression of these features.

  15. Single Nucleotide Polymorphism Analysis of Protamine Genes in Infertile Men

    Directory of Open Access Journals (Sweden)

    Ahamad Salamian

    2008-01-01

    Full Text Available Background: Single nucleotide polymorphism (SNPs are considered as one of the underlyingcauses of male infertility. Proper sperm chromatin packaging which involves replacement ofhistones with protamines has profound effect on male fertility. Over 20 SNPs have been reportedfor the protamine 1 and 2.Materials and Methods: The aim of this study was to evaluate the frequency of two previouslyreported SNPs using polymerase chain reaction (PCR-restriction fragment length polymorphism(RFLP approach in 35, 96 and 177 normal, oligozoospermic and azoospermic individuals. TheseSNPs are: 1. A base pair substitution (G at position 197 instead of T in protamine type 1 Openreading frame (ORF including untranslated region, which causes an Arg residue change to Serresidue in a highly conserved region. 2. cytidine nucleotide change to thymidine in position of 248of protamine type 2 ORF which caused a nonsense point mutation.Results: The two mentioned SNPs were not present in the studied population, thus concluding thatthese SNPs can not serves as molecular markers for male infertility diagnosis.Conclusion: The results of our study reveal that in a selected Iranian population, the SNP G197Tand C248T are completely absent and are not associated with male infertility and therefore theseSNPs may not represent a molecular marker for genetic diagnosis of male infertility.

  16. Avaliação histeroscópica em pacientes com infertilidade Hysteroscopic evaluation in patients with infertility

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    Ricardo Bassil Lasmar

    2010-08-01

    Full Text Available OBJETIVO: descrever os achados da histeroscopia em pacientes com infertilidade. MÉTODOS: série retrospectiva de 953 pacientes com diagnóstico de infertilidade avaliadas por histeroscopia. As 957 pacientes em pesquisa de infertilidade foram submetidas à histeroscopia, preferencialmente na primeira fase do ciclo menstrual. Quando necessário, foram realizadas as biópsias, dirigida (sob visão direta durante o exame ou orientada, utilizando uma cureta de Novak após definir o local a ser biopsiado durante o exame histeroscópico. Foram utilizadas porcentagens para determinação da frequência dos desfechos e teste de χ2 para correlações. O programa estatístico EpiInfo 2000 (CDC foi utilizado para análise dos dados. RESULTADOS: cavidade uterina normal foi encontrada em 436 casos (45,8%. Esse foi o diagnóstico mais frequente em mulheres com infertilidade primária e naquelas com nenhum ou um aborto (pPURPOSE: to describe hysteroscopy findings in infertile patients. METHODS: this was a retrospective series of 953 patients with diagnosis of infertility evaluated by hysteroscopy. A total of 957 patients investigated for infertility were subjected to hysteroscopy, preferentially during the first phase of the menstrual cycle. When necessary, directed biopsies (under direct visualization during the exam or guided biopsies were obtained using a Novak curette after defining the site to be biopsied during the hysteroscopic examination. Outcome frequencies were determined as percentages, and the χ2 test was used for the correlations. The statistical software EpiInfo 2000 (CDC was used for data analysis. RESULTS: a normal uterine cavity was detected in 436 cases (45.8%. This was the most frequent diagnosis for women with primary infertility and for women with one or no abortion (p<0.05. Abnormal findings were obtained in 517 of 953 cases (54.2%, including intrauterine synechiae in 185 patients (19.4%, endometrial polyps in 115 (12.1%, endocervical

  17. Correlation study between sperm concentration, hyaluronic acid-binding capacity and sperm aneuploidy in Hungarian patients.

    Science.gov (United States)

    Mokánszki, Attila; Molnár, Zsuzsanna; Ujfalusi, Anikó; Balogh, Erzsébet; Bazsáné, Zsuzsa Kassai; Varga, Attila; Jakab, Attila; Oláh, Éva

    2012-12-01

    Infertile men with low sperm concentration and/or less motile spermatozoa have an increased risk of producing aneuploid spermatozoa. Selecting spermatozoa by hyaluronic acid (HA) binding may reduce genetic risks such as chromosomal rearrangements and numerical aberrations. Fluorescence in-situ hybridization (FISH) has been used to evaluate the presence of aneuploidies. This study examined spermatozoa of 10 oligozoospermic, 9 asthenozoospermic, 9 oligoasthenozoospermic and 17 normozoospermic men by HA binding and FISH. Mean percentage of HA-bound spermatozoa in the normozoospermic group was 81%, which was significantly higher than in the oligozoospermic (Psex chromosomes (P=0.014) and chromosome 17 (P=0.0019), diploidy (P=0.03) and estimated numerical chromosome aberrations (P=0.004) were significantly higher in the oligoasthenozoospermic group compared with the other groups. There were statistically significant relationships (Pchromosome aberrations (r=-0.668) and between HA binding and estimated numerical chromosome aberrations (r=-0.682). HA binding and aneuploidy studies of spermatozoa in individual cases allow prediction of reproductive prognosis and provision of appropriate genetic counselling. Infertile men with normal karyotypes and low sperm concentrations and/or less motile spermatozoa have significantly increased risks of producing aneuploid (diminished mature) spermatozoa. Selecting spermatozoa by hyaluronic acid (HA) binding, based on a binding between sperm receptors for zona pellucida and HA, may reduce the potential genetic risks such as chromosomal rearrangements and numerical aberrations. In the present study we examined sperm samples of 45 men with different sperm parameters by HA-binding assay and fluorescence in-situ hybridization (FISH). Mean percentage of HA-bound spermatozoa in the normozoospermic group was significantly higher than the oligozoospermic, the asthenozoospermic and the oligoasthenozoospermic groups. Using FISH, disomy of sex

  18. The prevalence of ureaplasma urealyticum, mycoplasma hominis, chlamydia trachomatis and neisseria gonorrhoeae infections, and the rubella status of patients undergoing an initial infertility evaluation

    Science.gov (United States)

    Imudia, Anthony N.; Detti, Laura; Puscheck, Elizabeth E.; Yelian, Frank D.

    2008-01-01

    Purpose To determine the prevalence of positive test for Ureaplasma urealyticum (UU), Mycoplasma hominis (MH), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) infections, and their corresponding Rubella status when undergoing workup for infertility. Methods Retrospective chart review to determine infection status for UU, MH, CT, and NG as determined by cervical swab, as well as the serum Rubella antibody titer. Results A total of 46 patients of the patients reviewed were positive for UU (20.1%), three patients were positive for MH (1.3%), five patients were positive for CT (2.2%) and one patient was positive for NG (0.4%). Rubella immunity was confirmed in 90.3% of patients. Conclusion Approximately one quarter of women presenting to an infertility clinic seeking to conceive were found to have a positive test for UU, MH, CT or NG infection. Additionally, almost 10% of the patients were Rubella non-immune at the time of presentation for infertility evaluation. PMID:18202910

  19. Is hyperprolactinemia the main cause of infertility?

    Directory of Open Access Journals (Sweden)

    Mikaily J

    1999-06-01

    Full Text Available Hyperprolactinemia probably is one of infertility causes. Its incidence is 20% in infertile patients. In this study importance of hyperprolactinema was studied. Importance of hyperprolactinemia as a primary factor of infertility, is uncertain. We studied 500 infertile women in infertility center of Shariati hospital. Prevalence of hyperprolactinemia was 19%. Hyperprolactinemia as a sole cause of infertility was found in only 0.8%. There was a good correlation between galactorrhea and hyperprolactinemia (P=0.00007. Galactorrhea is not a screening test for hyperprolactinemia (sensivity=25%, but its specifity is high (91%. If we omit prolactin assay for patients without galactorrhea, we will miss primary cause of infertility in probably 0.1% of patients, so we find that performing prolactin assay for patients without galactorrhea is under question. Subpopulation of infertile patients with hyperprolactinemia are not different with infertile population in mean age (P=0.09, mean duration of infertility (P=0.28 and type of infertility. We suggest that hyperprolactinemia is not a primary or sole factor of infertility

  20. Testicular Shear Wave Elastography in Normal and Infertile Men: A Prospective Study on 601 Patients.

    Science.gov (United States)

    Rocher, Laurence; Criton, Aline; Gennisson, Jean-Luc; Izard, Vincent; Ferlicot, Sophie; Tanter, Mickael; Benoit, Gerard; Bellin, Marie France; Correas, Jean-Michel

    2017-04-01

    Our aim in the study described here was to prospectively establish the feasibility of using and reproducibility of testicular shear-wave elastography in the assessment of testicular stiffness in 62 normal patients and 539 infertile men with obstructive azoospermia (OA), non-Klinefelter syndrome non-obstructive azoospermia (non-KS NOA), Klinefelter syndrome NOA (KS NOA), oligoasthenoteratozoospermia (OAT) or a left varicocele. The feasibility rate was 96.9%, with an intra-class correlation coefficient of 0.85 (95% confidence interval: 0.83-0.88). Median stiffness (interquartile range) values were 2.4 kPa (2.0, 2.9), 2.1 kPa (1.8, 2.5), 2.4 kPa (2.0, 2.7), 2.0 kPa (1.7, 2.4), 2.6 kPa (2, 3.2) and 2.2 kPa (1.8, 2.6) for men with a normal testis (n = 108), OAT (n = 689), OA (n = 119), non-KS NOA (n = 183), KS NOA (n = 70) and varicocele (n = 132), respectively. Testicular shear wave elastography is a feasible and reproducible technique. A significant positive association was found between stiffness and testis volume (p = 0.001). Testicular stiffness was higher in OA than in non-KS NOA populations (p = 1.e-10) and in KS NOA than in NOA populations (p = 2.0e-8), but the substantial number of overlapping values limited the clinical impact.

  1. Infertility and Women

    Science.gov (United States)

    ... with production or quality of sperm. What causes female infertility? About 25 percent of women with infertility have ... 40 percent of infertility cases are due to female infertility, but just as many cases are due to ...

  2. Infertility: psychotherapeutic issues.

    Science.gov (United States)

    Rosenthal, M B

    1992-01-01

    In supportive therapy with infertility patients, the clinician tries to relieve dysphoria and enhance self-esteem. Dynamically informed supportive interventions are designed to decrease guilt that may relate to past sexual activities, sexually related diseases, or abortions. These interventions should also be empathetic, promote optimism and reality testing, help with problem solving, allow catharsis and ventilation, decrease feelings of isolation and loneliness, educate and clarify, and praise and encourage where appropriate. Mental health clinicians have an important role to play in the treatment of these patients, provided they learn enough about the psychology of the experience of infertility and about the technology utilized in its treatment. As the number of people seeking treatment for infertility grows, the need for skilled therapists for this population will grow at a parallel rate.

  3. Infertility despite surgery for cryptorchidism in childhood can be classified by patients with normal or elevated follicle-stimulating hormone and identified at orchidopexy

    DEFF Research Database (Denmark)

    Cortes, D; Thorup, J; Lindenberg, S

    2003-01-01

    FSH value. CONCLUSION: Despite surgery for cryptorchidism, infertility was probable in a third (44 of 135) of the patients. We expected high FSH values in these patients, but in 45% (20/44) the FSH values were normal. These patients may have relative FSH deficiency. At orchidopexy these patients were...

  4. Can intracytoplasmic sperm injection prevent total fertilization failure and enhance embryo quality in patients with non-male factor infertility?

    Science.gov (United States)

    Kim, Ju Yeong; Kim, Jee Hyun; Jee, Byung Chul; Lee, Jung Ryeol; Suh, Chang Suk; Kim, Seok Hyun

    2014-07-01

    To determine whether intracytoplasmic sperm injection (ICSI) could prevent total fertilization failure (TFF) and enhance the embryo quality in patients with non-male factor infertility. A total of 296 in vitro fertilization (IVF) cycles performed in patients with non-male factor infertility between April 2009 and March 2013 were included in this retrospective study. During the period, ICSI and conventional IVF were performed in 142 and 154 cycles, respectively. The usual indications for ICSI were in the cycles of patients with (1) known low fertilization rate, (2) repetitive implantation failure, (3) advanced maternal age, (4) presence of endometrioma, (5) low oocyte yield (number of oocytes ≤3), or (6) poor quality oocytes. The rate of TFF, normal fertilization, abnormal pronuclei (PN) formation, embryo quality, and pregnancy outcomes between the patients treated with ICSI and conventional IVF cycles were compared. The patients treated with ICSI (ICSI group, n=142) presented fewer number of oocytes than patients treated with conventional IVF cycles (n=154). The TFF rate was not different (4.2% vs. 0.6%, P=0.059), but the ICSI group presented a significantly higher rate of normal fertilization (83.4% vs. 79.1%, P=0.04) and lower rate of abnormal PN formation (3.9% vs. 13.3%, Pfertilization rate and the embryo quality. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  5. Long-term life and partnership satisfaction in infertile patients: a 5-year longitudinal study.

    Science.gov (United States)

    Schanz, Stefan; Reimer, Thorisa; Eichner, Martin; Hautzinger, Martin; Häfner, Hans-Martin; Fierlbeck, Gerhard

    2011-08-01

    To describe the long-term effects of infertility on life and partnership satisfaction. Longitudinal cohort study. A university outpatient andrology and gynecology infertility clinic. 275 men and 272 women treated for infertility between August 2000 and December 2001. None. The Life Satisfaction Questionnaire (FLZ), the Partnership Questionnaire (PFB), and sociodemographic items at baseline (T1) and 5 years later (T2). Compared with a representative sample, our male and female participants had higher Finance and Partnership scores and lower Health scores on the FLZ at T1. They also had markedly higher PFB scores, with the exception of Conflict Behavior. After 5 years (T2), 101 men and 113 women rated the Partnership and Sexuality FLZ subscales as well as all the PFB subscales statistically significantly lower than at baseline. Only the women rated the Self-esteem FLZ subscale lower than at baseline (T1). Participants who became parents had lower Leisure and Partnership FLZ subscale scores, and fathers had lower Finance FLZ subscale scores. Satisfaction declined over 5 years for both men and women, but only in the partnership-related domains. Women were more affected than men. The success of infertility treatment had only a minor influence on a couple's future satisfaction. Copyright © 2011. Published by Elsevier Inc.

  6. Expression of N-acetyl-glucosamine-6-O-sulfotransferase in the endometrium of implantation window stage from infertile patients

    Institute of Scientific and Technical Information of China (English)

    Dai Hui-hua; Zhang Hong-mei; Liu Jia-yin

    2007-01-01

    Objective: To observe the expression of N-acetyl-glucosamine-6-O-sulfotransferase (GN-6-ST)in the endometrium during the window stage of implantation from infertile women before IVF-ET treatment, we compared the GN-6-ST gene expression level between the women with succeeded and failed implantation, and investigated the roles of selectin and its ligands in the embryo implantation.Methods: The hysteroscopy and endometrial biopsies were performed in patients prior to undergoing IVF-ET treatment in the IVF Center of the First Affiliated Hospital of Nanjing Medical University from July 2004 to March 2005.Fourteen patients who succeeded in implantation were taken as study group, while the 28 infertile patients with failed implantation served as control group.The RT-PCR method was used to detect the mRNA levels of N-ac-etyl-glucosamine-6-O-sulfotransferase in the endometrium during the window stage of imp-lantation of the women from both groups.Results: For these infertile patients with succeeded implantation, the average mRNA expression level of acetylglucosamine-6-O-sulfotransferase in the endometrium during the window stage of implantation was (0.65±0.33),while for those with failed implantation cycle, the average mRNA expression level was (0.41±0.36), which was significantly lower than that of study group, P<0.05.Conclusions: The combination of the selectin and ligands may play a role in the embryo implantation capacibility.

  7. Effect of different ultrasound contrast materials and temperatures on patient comfort during intrauterine and tubal assessment for infertility

    Energy Technology Data Exchange (ETDEWEB)

    Fenzl, Vanja, E-mail: vanja.radic@inet.hr [Department of Gynecology and Obstetrics, University Hospital “Merkur”, Zajčeva 19 (Croatia); University of Applied Health Studies, Mlinarska Cesta 38, 10000 Zagreb (Croatia)

    2012-12-15

    Hysterosalpingo-contrast sonography (HyCoSy) is safe and easy to perform outpatient method in the evaluation of female infertility. During this procedure a certain level of discomfort and pain are experienced by patients. On the basis of reducing avoidable pain inductors the aim of this study was to compare pain sensation due to different warmth of applied contrasts (sterile saline and Echovist{sup ®}). Prospective and randomized study was performed on patients requiring tubal and uterine assessment during standard infertility work up. One group of patients was examined using both contrasts at room temperature and the other group using preheated contrasts at body temperature. Pain experience of the procedure was rated by patients for each contrast by numerical scale (0–10) immediately after the procedure. There was significant statistical difference between pain scores during application of two contrasts in each group; Echovist induces significantly less pain in comparison to sterile saline at the same temperature (P = 0.002, 0.001). Between two groups there is also statistically significant difference in pain during introduction of the same contrast at different temperature (P < 0.001). The most tolerable for the patient is body temperature of the applied contrasts although their structure and concentrations can be another factor associated with tolerability of the procedure.

  8. Novel association between sperm deformity index and oxidative stress-induced DNA damage in infertile male patients

    Institute of Scientific and Technical Information of China (English)

    Tamer M. Said; Nabil Aziz; Rakesh K. Sharma; Iwan Lewis-Jones; Anthony J. Thomas Jr; Ashok Agarwal

    2005-01-01

    Aim: To investigate the impact of abnormal sperm morphology using the sperm deformity index (SDI) on reactive oxygen species (ROS) production and its correlation with sperm DNA damage. Methods: Semen samples were collected from men undergoing infertility screening (n = 7) and healthy donors (n = 6). Mature spermatozoa were isolated and incubated with 5 mmol/L β-nicotinamide adenine dinucleotide phosphate (NADPH) for up to 24 h to induce ROS. Sperm morphology was evaluated using strict Tygerberg's criteria and the SDI. ROS levels and DNA damage were assessed using chemiluminescence and terminal deoxynucleotidyl transferase-mediated fluoresceindUTP nick end labeling (TUNEL) assays, respectively. Results: SDI values (median [interquartiles]) were higher in patients than donors (2 [1.8, 2.1] vs. 1.53 [1.52, 1.58], P = 0.008). Aliquots treated with NADPH showed higher ROS levels (1.22 [0.30, 1.87] vs. 0.39 [0.10, 0.57], P = 0.03) and higher incidence of DNA damage than those not treated (10 [4.69, 24.85] vs. 3.85 [2.58, 5.10], P = 0.008). Higher DNA damage was also seen following 24 h of incubation in patients compared to donors. SDI correlated with the percentage increase in sperm DNA damage following incubation for 24 h in samples treated with NADPH (r = 0.7, P = 0.008) and controls (r = 0.58, P = 0.04).Conclusion: SDI may be a useful tool in identifying potential infertile males with abnormal prevalence of oxidative stress (OS)-induced DNA damage. NADPH plays a role in ROS-mediated sperm DNA damage, which appears to be more evident in infertile patients with semen samples containing a high incidence of morphologically abnormal spermatozoa.

  9. Imaging female infertility.

    Science.gov (United States)

    Sadow, Cheryl A; Sahni, V Anik

    2014-02-01

    The purpose of this pictorial review is to discuss causes of female infertility, in particular, those etiologies in which imaging plays a key role in detection. Included are disorders of cervical, ovarian, fallopian tube, and uterine origin. We also discuss the role of various imaging modalities including hysterosalpingography, pelvic ultrasonography, hysterosonography, and pelvic MR imaging in elucidating the cause of female infertility. Radiologists need to know the conditions to be aware of when these patients are sent for diagnostic imaging, as well as how to direct further management, if necessary, should an abnormality be detected.

  10. Male infertility microsurgical training

    Institute of Scientific and Technical Information of China (English)

    Akanksha Mehta; Philip S Li

    2013-01-01

    Microsurgical training is imperative for urologists and clinical andrologists specializing in male infertility.Success in male infertility microsurgery is heavily dependent on the surgeon's microsurgical skills.Laboratory-based practice to enhance microsurgical skills improves the surgeon's confidence,and reduces stress and operating time,benefiting both the patient and the surgeon.This review provides guidelines for setting up a microsurgical laboratory to develop and enhance microsurgical skills using synthetic and animal models.The role of emerging techniques,such as robotic-assisted microsurgery,is also discussed.

  11. Varicocele and male infertility

    DEFF Research Database (Denmark)

    Fuglesang Jensen, Christian S.; Østergren, Peter; Dupree, James M

    2017-01-01

    to explain the differential effect of varicoceles on infertility. As a consequence, careful patient selection for treatment based on couple fertility status, varicocele grade, and semen quality is critical for achieving a chance of a subsequent pregnancy. A substantial amount of data on the effects...

  12. 继发不孕沙眼衣原体和解脲支原体的检测与治疗%Inspect and Therapy of Chlamydia Trachomatis and Ureaplasna Urealyticam in Secondary Infertile Patients

    Institute of Scientific and Technical Information of China (English)

    谌小卫; 尹玉竹; 滕奔琦; 李小毛; 范建辉

    2002-01-01

    Objective To study the infection and therapy of Chlamydia Trachomatis(CT) and Ureaplasna Urealyticam(UU) in secondary infertile patients. Methods Cervical discharge of secondary infertile patients was detected for CT and UUby the techonology of Polymerase Chain Reaction(PCR). Results The positive rate of CT and UU were 42.3 % and 35.9%respectively in infertile group,which were higher than those in control group (P< 0.05) .Higher salpingemphraxis rate occurredin infertile cases with the history of intrauterine operation ( P < 0.025). Compared with cases with unobstructed fallopian tube,salpingemphraxis patients had higher positive rate of CT or UU ( P < 0.05). After systemic therapy, 36 cases (46.2 % ) werepregnant. Conclusions It is suggesive that secondary infertility is related to salpingemphraxis resulting from genital CT and UUinfection,and timely therapy can improve the prognosis of secondary infertility.

  13. Original article Expectations towards medical personnel – a study with infertility clinic patients

    Directory of Open Access Journals (Sweden)

    Katarzyna Redo

    2014-09-01

    Full Text Available Background Contacts with medical personnel are important for patients’ experiences. The role of physicians’ psychosocial competence was noted in Polish studies, but systematic analyses of infertile patients’ expectations have not been conducted. This study was designed to learn about patients’ views on relationships with medical personnel. It was assumed that: 1 staff involvement in infertility treatment would be reflected in expectations towards persons in different roles, 2 expectations might be related to patients’ gender, duration of infertility, and type of treatment, 3 expectations of couples would be related. Participants and procedure Fifty-one married couples filled in a purposely designed questionnaire. Items related to information, attitudes and support were divided into three sections – expectations towards physicians, other medical personnel, psychologists – and were scored on a scale of 1 to 5 points. Results No gender effect of duration of treatment, type of infertility or treatment method on expectations was found. Partners expected the same level of information from physicians and the same level of emotional support from psychologists. Other expectations were consistently higher in women. There was a clear division of expectations towards different groups of personnel – the expectation to make the best medical choices was assigned to physicians, while the expectation to provide a supportive relationship and coping skills was assigned to psychologists, but all were expected to respect patients’ privacy, choices and decisions. Conclusions The findings indicate the division of expectations towards different groups of personnel, with the tendency of women to articulate their expectations more clearly and strongly, but towards the same aspects of staff functioning as men do.

  14. NF kappaB expression increases and CFTR and MUC1 expression decreases in the endometrium of infertile patients with hydrosalpinx: a comparative study

    Directory of Open Access Journals (Sweden)

    Song Yong

    2012-10-01

    Full Text Available Abstract Background Hydrosalpinx are associated with infertility, due to reduced rates of implantation and increased abortion rates. The aims of this study were to investigate the expression of cystic fibrosis transmembrane conductance regulator (CFTR, nuclear factor kappa B (NF KappaB and mucin-1 (MUC-1, and analyze the correlation between the expression of CFTR and NF KappaB or MUC1, in the endometrium of infertile women with and without hydrosalpinx. Methods Thirty-one infertile women with laparoscopy-confirmed unilateral or bilateral hydrosalpinx and 20 infertile women without hydrosalpinx or pelvic inflammatory disease (control group were recruited. Endometrial biopsy samples were collected and the expression of CFTR, NF KappaB and MUC1 were analyzed using immunohistochemistry and quantitative real-time PCR. Results CFTR, NF KappaB and MUC1 mRNA and protein expression tended to increase in the secretory phase compared to the proliferative phase in both groups; however, these differences were not significantly different. The endometrium of infertile patients with hydrosalpinx had significantly higher NF KappaB mRNA and protein expression, and significantly lower CFTR and MUC1 mRNA and protein expression, compared to control infertile patients. A positive correlation was observed between CFTR and MUC1 mRNA expression (r = 0.65, P CFTR mRNA and NF KappaB mRNA expression (r = −0.59, P Conclusions Increased NF KappaB expression and decreased CFTR and MUC1 expression in the endometrium of infertile patients with hydrosalpinx reinforce the involvement of a molecular mechanism in the regulation of endometrial receptivity.

  15. ROLE OF DIAGNOSTIC HYSTEROLAPAROSCOPY IN EVALUATION OF FEMALE INFERTILITY

    OpenAIRE

    Jayanthy; Suvarna; Nirmala

    2016-01-01

    AIM To evaluate the role of hysterolaparoscopy in female infertility. SETTINGS AND DESIGN Patients with female infertility presenting to outpatient Department of Obstetrics and Gynaecology in Kempegowda Institute of Medical sciences, Bengaluru were evaluated for infertility by hysterolaparoscopy and chromopertubation. MATERIALS AND METHODS Seventy consenting subjects excluding male factor infertility with normal hormonal profile and no contraindication to ...

  16. [TNF-alpha, C-reactive protein and serum adiponectin modified in infertile patients with insulin resistance].

    Science.gov (United States)

    Vital Reyes, Victor Saúl; López Alarcón, Mardya; Zavala Ortega, Isabel; Hinojosa Cruz, Juan Carlos; Téllez Velasco, Sergio; Gris Calvo, Judith

    2008-11-01

    Women's reproductive potential is closely related to nutritional status. Some of the molecules that participate in ovarian regulation are produced in the adipose tissue, and therefore their production is associated with adiposity. To determine serum leptin, adiponectin, C-reactive protein, interleukin-6, and tumor necrosis factor alpha in infertile women with or without insulin resistance; and to associate these molecules with adiposity. Thirty-one infertile women were included. Nutritional status was evaluated through clinical and biochemical parameters. Patients were stratified according with their body mass index and the presence of insulin resistance. For statistics, parametric analyses were conducted. The prevalence of overweight was 67.5%; high adiposity was present in 92.3% and central distribution of fat in 96.2% of studied women. Hypercholesterolemia was found in 32.3% of patients, hypertriglyceridemia in 25.8%, and 61.3% presented hyperinsulinemia. Overweight women presented lower adiponectin, and higher TNF-alpha and C-reactive protein concentrations, than those with normal body mass index (p dislipidemias, and IR was high in our population studied. We conclude that adiposity is closely associated with some of the molecules that participate in the reproductive process and that also regulate inflammatory responses.

  17. Coping with infertility: a transcultural perspective.

    Science.gov (United States)

    Li, Jing; Liu, Botao; Li, Min

    2014-09-01

    To review the most important and interesting articles in infertility published in the last year. This systematic review covers 60 studies published in journals or dissertations in Science Direct and PubMed in the last year, including those related to prevention and treatment as well as related psychosocial services in infertility. We also propose some suggestions about coping with infertility in China. Infertility is a multidisciplinary problem that requires medical, social, and political efforts to prevent and offer infertile patients the best diagnostic, therapeutic, and psychosocial services. Cultural factors should be taken into consideration when designing coping strategies.

  18. Karyotype analysis in large sample cases from Shenyang Women's and Children's hospital: a study of 16,294 male infertility patients.

    Science.gov (United States)

    Gao, M; Pang, H; Zhao, Y-H; Hua, J; Tong, D; Zhao, H; Liu, Y; Zhao, Y; Zhang, M; Yan, X-J; Chen, H; Ma, H-P; Jin, T-Y; Dong, S-L

    2017-05-01

    To explore that it is necessary to routinely detect chromosomes in infertile patients, we investigated peripheral blood lymphocyte karyotype in 16,294 male infertile patients in the north-east of China and analysed the incidence and type of chromosomal anomaly and polymorphism. G-banding karyotype analysis of peripheral blood lymphocytes was performed in 16,294 cases. Semen analysis was performed three times in all the men. PCR and FISH confirmed the presence of the SRY gene. The rate of chromosomal anomaly in the 16,294 male infertile patients was 4.15% (677/16,294). The rates of chromosomal anomaly were 0.24% in normal semen group, 12.6% in light oligoasthenospermia group, 4.7% in moderate-to-severe oligoasthenospermia group and 9.59% in azoospermia group. There are two male infertile patients with 45,X chromosome karyotype. One X male patient had confirmed the presence of the SRY gene and FISH analysis demonstrated its location on the p arm of chromosome 13. The other X male patient had not found SRY gene in its whole-genome DNA. Meanwhile, sperm motility is slightly oligo-asthenozoospermic at the age of 35-39 and nearly azoospermic at the age of 40-45. As the rates of chromosomal anomaly are 0.24% and 12.6% even in normal semen group and light oligoasthenospermia group, the rates of chromosomal polymorphism are 5.36% and 25.51% in normal semen group and light oligoasthenospermia group, respectively; it is necessary to explore peripheral blood lymphocyte karyotype in all infertile couples. We mentioned that Y, 1, 2, 9 and 12 chromosomes were quite important about male infertility. These findings demonstrate that autosomal retention of SRY can be submicroscopic and emphasise the importance of PCR and FISH in the genetic workup of the monosomic X male. At the same time, it suggested that male infertility might be related to meiotic disturbances with spermatogenetic arrest in Y-autosome translocations, which could result in infertility by reduction of sperm

  19. Incorporating patient preference into the management of infertility in women with polycystic ovary syndrome

    Directory of Open Access Journals (Sweden)

    Okoroafor UC

    2012-05-01

    Full Text Available Ugochi C Okoroafor, Emily S JungheimDepartment of Obstetrics and Gynecology, Washington University, St Louis, MO, USAAbstract: Polycystic ovary syndrome (PCOS is a heterogeneous condition characterized by anovulation, hyperandrogenism, and polycystic ovaries. Because of the heterogeneous nature of PCOS, women affected by the condition often require a customized approach for ovulation induction when trying to conceive. Treating symptoms of PCOS in overweight and obese women should always incorporate lifestyle changes with the goal of weight-loss, as many women with PCOS will ovulate after losing 5%–10% of their body weight. On the other hand, other factors must be considered including the woman’s age, age-related decline in fertility, and previous treatments she may have already tried. Fortunately, multiple options for ovulation induction exist for women with PCOS. This paper reviews specific ovulation induction options available for women with PCOS, the benefits and efficacy of these options, and the related side effects and risks women can anticipate with the various options that may affect treatment adherence. The paper also reviews the recommended evidence-based strategies for treating PCOS-related infertility that allow for incorporation of the patient’s preference. Finally, it briefly reviews emerging data and ongoing studies regarding newer agents that have shown great promise as first-line agents for the treatment of infertility in women with PCOS.Keywords: polycystic ovary syndrome, anovulation, clomiphene citrate, letrozole, metformin, obesity

  20. Understanding Infertility - The Basics

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    Full Text Available ... Facts About Infertility FAQs About Infertility FAQs About the Psychological Component of Infertility FAQs About Cloning and ... Page not found! Please click on one of the links in the navigation bar. FAQs Reproductive Health ...

  1. Understanding Infertility - The Basics

    Medline Plus

    Full Text Available ... Home FAQs Frequently Asked Questions Quick Facts About Infertility FAQs About Infertility FAQs About the Psychological Component of Infertility FAQs About Cloning and Stem Cell Research SART's ...

  2. Characterisation of the bacterial community in expressed prostatic secretions from patients with chronic prostatitis/chronic pelvic pain syndrome and infertile men: a preliminary investigation

    Institute of Scientific and Technical Information of China (English)

    Dong-Sheng Hou; Wen-Min Long; Jian Shen; Li-Ping Zhao; Xiao-Yan Pang; Chen XU

    2012-01-01

    The expressed prostatic secretions (EPSs) of men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS),infertile men and normal men were subjected to microbiological study.EPSs were collected from the subjects,which included 26 normal men,11 infertile patients and 51 CP/CPPS patients.DNA was extracted from each specimen,and the V3 regions of the 16S rRNA genes were amplified using universal bacterial primers.The results showed that the EPS 16S rRNA gene-positive rate in the CP/CPPS and infertile patients was much higher than in the normal men,but without any difference among the three patient groups.The denaturing gradient gel electrophoresis (DGGE) method was used to characterize the EPS bacterial community structure of the prostate fluid from patients with CP/CPPS or infertility issues.Principal component analysis (PCA) and partial least squares (PLS) analyses of PCR-DGGE profiles revealed that the EPS bacterial community structure differed among the three groups.Three bands were identified as the key factors responsible for the discrepancy between CP/CPPS patients and infertile patients (P<0.05).Two bands were identified as priority factors in the discrepancy of category ⅢA and category ⅢB prostatitis patients (P<0.05).According to this research,the ecological balance of the prostate and low urethra tract,when considered as a microenvironment,might play an important role in the maintenance of a healthy male reproductive tract.

  3. Apoptosis is increased and cell proliferation is decreased in out-of-phase endometria from infertile and recurrent abortion patients

    Directory of Open Access Journals (Sweden)

    Irigoyen Marcela

    2010-10-01

    Full Text Available Abstract Background Various endometrial abnormalities have been associated with luteal phase deficiency: a significant dyssynchrony in the maturation of the glandular epithelium and the stroma and a prevalence of out-of-phase endometrial biopsy specimens. Out-of phase endometrium is a controversial disorder related to failed implantation, infertility and early pregnancy loss. Given that the regulation of the apoptotic process in endometrium of luteal phase deficiency is still unknown, the aim of this study was to evaluate cell proliferation, apoptosis and the levels of the main effector caspase, caspase-3 in the luteal in-phase and out-of-phase endometrium. Methods Thirty-seven endometrial samples from sterile or recurrent abortion patients were included in this study: 21 in-phase samples (controls and 16 samples with out-of-phase endometrium. Biopsy specimens of eutopic endometrium were obtained from all subjects during days 21-25 of the menstrual cycle. The endometrium with endometrial maturity of cycle day 25 or less at the time of menstruation was considered out-of phase. Endometrial tissues were fixed in 10% buffered formaldehyde. For apoptosis quantification, sections were processed for in situ immunohistochemical localization of nuclei exhibiting DNA fragmentation, by the terminal deoxynucleotidyl transferase (TdT-mediated dUTP digoxygenin nick-end labeling (TUNEL technique. Expressions of Proliferating Cell Nuclear Antigen (PCNA as a marker of cell proliferation, and of cleaved caspase-3 as a marker of apoptosis, were assessed by immunohistochemistry in the luteal in-phase and out-of-phase endometrium from infertile and recurrent abortion patients. Results Luteal out-of-phase endometrium had increased apoptosis levels compared to in-phase endometrium (p Conclusions this study represents the first report describing variations at the cell proliferation and cell death levels in the out-of-phase endometrium in comparison with in

  4. Patients' attitudes to medical and psychosocial aspects of care in fertility clinics: Findings from the Copenhagen Multi-centre Psychosocial Infertility (COMPI) Research Programme

    DEFF Research Database (Denmark)

    Schmidt, L; Holstein, B E; Boivin, J

    2003-01-01

    among infertile people. METHODS: We conducted an epidemiological study based on questionnaires among all new couples attending five fertility clinics with a response rate of 80.0% and a total of 2250 patients. RESULTS: The vast majority of both men and women considered a high level of medical...

  5. High frequency of chronic bacterial and non-inflammatory prostatitis in infertile patients with prostatitis syndrome plus irritable bowel syndrome.

    Directory of Open Access Journals (Sweden)

    Enzo Vicari

    Full Text Available BACKGROUND: Although prostatitis syndrome (PS and irritable bowel syndrome (IBS are common disorders, information on the prevalence of IBS in infertile patients with PS is relatively scanty. Therefore, this study was undertaken to estimate the frequency of PS and IBS and to evaluate the prevalence of the various diagnostic categories of prostatitis. METHODOLOGY/PRINCIPAL FINDINGS: This study enrolled 152 patients with PS, diagnosed by the NIH-Chronic Prostatitis Symptom Index (NIH-CPSI in an andrological setting, and 204 patients with IBS, diagnosed according to the Rome III diagnostic criteria in a gastroenterological setting. The patients with PS were asked to fulfill the Rome III questionnaire for IBS, whereas patients with IBS were asked to complete the NIH-CPSI. The simultaneous presence of PS and IBS was observed in 30.2% and 31.8% of the patients screened by andrologists and gastroenterologists, respectively. Altogether, 111 patients had PS plus IBS (31.2%. They had a total NIH-CPSI and pain subscale scores significantly higher than patients with PS alone. Gastrointestinal symptoms in patients with PS plus IBS were similar to those reported by patients with IBS alone and significantly greater in patients with PS alone. Patients with PS plus IBS had a significantly higher frequency of chronic bacterial prostatitis (category II and lower of non-inflammatory prostatitis (category IIIB, compared to patients with PS alone. The frequency of inflammatory prostatitis (category IIIA resulted similar. CONCLUSIONS/SIGNIFICANCE: Prostatitis syndromes and IBS are frequently associated in patients with PS- or IBS-related symptoms. These patients have an increased prevalence of chronic bacterial and non-inflammatory prostatitis.

  6. Obesity leads to higher risk of sperm DNA damage in infertile patients

    Science.gov (United States)

    Dupont, Charlotte; Faure, Céline; Sermondade, Nathalie; Boubaya, Marouane; Eustache, Florence; Clément, Patrice; Briot, Pascal; Berthaut, Isabelle; Levy, Vincent; Cedrin-Durnerin, Isabelle; Benzacken, Brigitte; Chavatte-Palmer, Pascale; Levy, Rachel

    2013-01-01

    There has been a growing interest over the past few years in the impact of male nutrition on fertility. Infertility has been linked to male overweight or obesity, and conventional semen parameter values seem to be altered in case of high body mass index (BMI). A few studies assessing the impact of BMI on sperm DNA integrity have been published, but they did not lead to a strong consensus. Our objective was to explore further the relationship between sperm DNA integrity and BMI, through a 3-year multicentre study. Three hundred and thirty male partners in subfertile couples were included. Using the terminal uridine nick-end labelling (TUNEL) assay, we observed an increased rate of sperm DNA damage in obese men (odds ratio (95% confidence interval): 2.5 (1.2–5.1)). PMID:23792341

  7. Management of Unexplained Infertility

    Directory of Open Access Journals (Sweden)

    Ozgur Kan

    2014-06-01

    In the management of the unexplained infertility, the initial treatment must be observational approach and changing the life style. It is demonstrated that using only the clomiphene citrate or intrauterine insemination is not effective. For this reason, as the patients age and ovarian reserve considered, after the observational approach, the initial treatment must be the combination of clomiphene citrate and intrauterine insemination. With this approach, pregnancy rate is rises to 10 percent for a cycle. Management wise, choosing the cheapest effective treatment for increased fertilization should be the priority, before moving onto more expensive and aggresive approaches. Apart from the diagnostic work-up, which more or less the same for every patient, treatment protocol should be individualised for every infertile couple. [Archives Medical Review Journal 2014; 23(3.000: 506-518

  8. Frozen-thawed spermatozoa from oligozoospermic ejaculates are susceptible to in situ DNA fragmentation in polyvinylpyrrolidone-based sperm-immobilization medium.

    Science.gov (United States)

    Salian, Sujit Raj; Kalthur, Guruprasad; Uppangala, Shubhashree; Kumar, Pratap; Adiga, Satish Kumar

    2012-08-01

    To elucidate the effect of sperm immobilization media that are and are not based on polyvinylpyrrolidone (PVP) on the DNA integrity of fresh and frozen-thawed spermatozoa during standard intracytoplasmic sperm injection (ICSI) conditions. Experimental prospective study. Embryology research laboratory. Forty-six ejaculates from normozoospermic and oligozoospermic men. Assessment of sperm DNA fragmentation by single-cell gel electrophoresis assay. DNA integrity of fresh and frozen-thawed spermatozoa from normozoospermic and oligozoospermic ejaculates exposed to PVP-based and non-PVP-based media. Exposure of fresh and frozen thawed spermatozoa from normozoospermic and oligozoospermic ejaculates to PVP-based medium in an ICSI dish for 30 minutes statistically significantly increased the DNA fragmentation. In contrast, the extent of DNA fragmentation in non-PVP-based medium did not statistically significantly differ from control. A PVP-based medium can induce a statistically significant amount of sperm DNA fragmentation in an ICSI dish, and frozen-thawed sperm from oligozoospermic ejaculates are more susceptible to in situ DNA fragmentation. Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  9. Infertility Infertilidad

    Directory of Open Access Journals (Sweden)

    Práxedes Rojas Quintana

    2011-08-01

    Full Text Available Literature review on the main issues related to infertile couples. It includes concept and classification, physiology of ovulation, causes in women and men, basic tests that are commonly performed evolution and prognosis, and health actions to provide appropriate orientation to the infertile couple. It is aimed at creating a teaching complementary material for Medicine and Nursing students, as well as for residents and specialists in general medicine and gynecology.Revisión bibliográfica sobre los principales temas referidos a la infertilidad de las parejas. Incluye concepto y clasificación, fisiología de la ovulación, causas en la mujer y en el hombre, exámenes complementarios básicos que se les realiza, evolución y pronóstico, así como acciones de salud para la orientación correcta de la pareja infértil. Tiene como objetivo crear un material de apoyo a la docencia, para estudiantes de la carrera de Medicina y de Enfermería, así como para residentes y especialistas en Medicina General Integral y Ginecoobstetricia.

  10. Male Infertility and Its Causes in Human

    Directory of Open Access Journals (Sweden)

    Toshinobu Miyamoto

    2012-01-01

    Full Text Available Infertility is one of the most serious social problems facing advanced nations. In general, approximate half of all cases of infertility are caused by factors related to the male partner. To date, various treatments have been developed for male infertility and are steadily producing results. However, there is no effective treatment for patients with nonobstructive azoospermia, in which there is an absence of mature sperm in the testes. Although evidence suggests that many patients with male infertility have a genetic predisposition to the condition, the cause has not been elucidated in the vast majority of cases. This paper discusses the environmental factors considered likely to be involved in male infertility and the genes that have been clearly shown to be involved in male infertility in humans, including our recent findings.

  11. Seminal vesicles of infertile patients with male accessory gland infection: ultrasound evaluation after prolonged treatment with tadalafil, a selective phosphodiesterase-5 inhibitor.

    Science.gov (United States)

    La Vignera, S

    2013-12-01

    The aim of this study was to investigate possible ultrasound seminal vesicle (SV) changes in infertile patients with 'hypertrophic-congestive' (HCUF) or 'fibro-sclerotic' (FSUF) ultrasound form of male accessory gland infection (MAGI) after prolonged administration of tadalafil (TAD), a selective phosphodiesterase-5 inhibitor. Forty infertile patients with HCUF and 40 patients with FSUF and erectile dysfunction were selected and arbitrarily divided into two groups, who were prescribed TAD 5 mg daily for 3 months, the first 20 consecutive patients with HCUF (group A1) or FSUF (group A2) or placebo, the second 20 consecutive patients with HCUF (group B1) or FSUF (group B2). All patients underwent scrotal and prostate-vesicular transrectal ultrasound evaluation and semen analysis (WHO, 2010) before and after treatment. Group A1 patients showed a significant reduction in fundus/body ratio and higher pre- and post-ejaculatory body SV antero-posterior diameter difference compared with the other three groups. These patients showed also a significant increase in SV ejection fraction and a significant improvement in the total sperm count, progressive motility, seminal levels of fructose and ejaculate volume. These results suggest that infertile patients with HCUF had an improvement in SV ultrasound features suggestive of chronic inflammation after daily treatment with low doses of TAD.

  12. Immunology and male infertility.

    Science.gov (United States)

    Mumford, D M

    1978-10-01

    This article has attempted to review evidence that suggests that immune factors may be operative in a small but significant number of infertile men. Although our current understanding of the possible processes by which autosensitization to previously sequestered reproductive antigens occurs is incomplete, there are laboratory assays presently available that give an indication, but do not prove, that immune factors may be contributing to the infertile state. Continued research is needed to develop new assays and more purified sperm antigens, which might enhance our knowledge of the underlying immunoreproductive changes. Until these are available, the following procedures should be considered when investigating a patient with infertility of suspected immune origin. The patient's history should be taken, and a physical examination should be performed. A complete blood count, urinalysis, and complete semen analysis and culture should be taken. Next, in vivo cervical tests (Sims-Huhner) are performed, followed by sperm antibody assessment (serum, semen) and perhaps in vitro cervical mucus sperm assays (especially the crossed hostility test). After the tests have been completed, the following possibe treatments exist: 1. Treatment of underlying infections 2. Correction of obstructions 3. Corticosteroid (or testosterone?) therapy 4. Washed sperm insemination 5. First portion of fresh ejaculate insemination 6. Artificial insemination with homologous donor 7. Adoption.

  13. Nursing Progress and Psychological Characters of Infertile Patients%不孕症患者的心理特点及其护理进展

    Institute of Scientific and Technical Information of China (English)

    黄丹

    2012-01-01

    总结近年来的相关文献,探讨不孕症患者的心理特点及护理对策,分析不孕症患者不良情绪产生的原因、心理特点及常用护理方法等问题,发现思想、家庭及疾病是导致不孕症的主要原因,而由此产生的焦虑、抑郁情绪以及性生活满意度降低是患者主要心理特点,应采取有针对性的护理方法,给予不孕症妇女宽松舒适的医疗、生活、社交环境以及支持、理解和帮助,不仅可增强其自信心和自尊心,而且有助于缓解其焦虑抑郁情绪,从而提高受孕率.%Psychological characters and nursing strategies of infertile patients were explored by reviewing the related literature in recent years. The main reasons being the cause of infertility were thinking, family and disease through analyzing the source of bad moods in infertile patients, mental characters of infertility and common nursing method, therefore originated mental characters of the patients were anxiety, depression and low sexual satisfaction and the corresponding nursing should be performed to provide comfortable medical care, life, social environment, support, understanding and help to infertile women, which would help to not only enhance the confidence and self-respect, but also alleviate anxiety and depression thereby to raise conception rate.

  14. Low Birth Weight Is Associated with a Decreased Overall Adult Health Status and Reproductive Capability – Results of a Cross-Sectional Study in Primary Infertile Patients

    Science.gov (United States)

    Boeri, Luca; Ventimiglia, Eugenio; Capogrosso, Paolo; Ippolito, Silvia; Pecoraro, Angela; Paciotti, Marco; Scano, Roberta; Galdini, Alessandro; Valsecchi, Luca; Papaleo, Enrico; Montorsi, Francesco; Salonia, Andrea

    2016-01-01

    Individuals born with low birth weight (LBW) risk cardiometabolic complications later in life. However the impact of LBW on general health status and male reproductive function has been scantly analysed. We investigated the clinical and seminal impact of different birth weights (BW) in white-European men presenting for primary couple’s infertility. Demographic, clinical, and laboratory data from 827 primary infertile men were compared with those of 373 consecutive fertile men. Patients with BW ≤2500, 2500–4200, and ≥4200gr were classified as having LBW, normal (NBW), and high BW (HBW), respectively. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI). Testicular volume was assessed with a Prader orchidometer. Semen analysis values were assessed based on 2010 WHO reference criteria. Descriptive statistics and regression models tested associations between semen parameters, clinical characteristics and BW categories. LBW, NBW and HBW were found in 71 (8.6%), 651 (78.7%) and 105 (12.7%) infertile men, respectively. LBW was more frequent in infertile patients than fertile men (p = 0.002). Infertile patients with LBW had a higher rate of comorbidities (p = 0.003), lower mean testicular volume (p = 0.007), higher FSH (p = 0.02) and lower tT levels (p = 0.04) compared to other BW groups. Higher rates of asthenozoospermia (p = 0.02) and teratozoospermia (p = 0.03) were also found in LBW men. At logistic regression models, LBW was univariably associated with pathologic progressive motility (p≤0.02) and pathologic sperm morphology (p<0.005). At multivariable logistic regression analysis, LBW achieved independent predictor status for both lower sperm motility and pathologic sperm morphology (all p≤0.04). Only LBW independently predicted higher CCI values (p<0.001). In conclusion, we found that LBW was more frequent in infertile than in fertile men. Infertile individuals with LBW showed a higher rate of comorbidities and

  15. ROLE OF DIAGNOSTIC HYSTEROLAPAROSCOPY IN EVALUATION OF FEMALE INFERTILITY

    Directory of Open Access Journals (Sweden)

    Jayanthy

    2016-01-01

    Full Text Available AIM To evaluate the role of hysterolaparoscopy in female infertility. SETTINGS AND DESIGN Patients with female infertility presenting to outpatient Department of Obstetrics and Gynaecology in Kempegowda Institute of Medical sciences, Bengaluru were evaluated for infertility by hysterolaparoscopy and chromopertubation. MATERIALS AND METHODS Seventy consenting subjects excluding male factor infertility with normal hormonal profile and no contraindication to laparoscopy underwent ultra-sonography. Then all patients were subjected to combined hysterolaparoscopy including chromopertubation and the results were recorded. STATISTICAL ANALYSIS USED T-test. RESULTS We studied 70 patients comprising of 40(57.1% cases of primary infertility and 30(42.9% patients of secondary infertility. In our study most commonly found pathologies were PCOD, endometriosis and tubal blockage. CONCLUSIONS Results show that hysterolaparoscopy has a promising role in diagnosing and treating infertility. hysterolaparoscopy has emerged as a new hope for infertile couples before they proceed to time-consuming and expensive assisted reproduction techniques.

  16. Psychopathology, emotional aspects and psychological counselling in infertility: a review.

    Science.gov (United States)

    De Berardis, D; Mazza, M; Marini, S; Del Nibletto, L; Serroni, N; Pino, M C; Valchera, A; Ortolani, C; Ciarrocchi, F; Martinotti, G; Di Giannantonio, M

    2014-01-01

    Over the years, infertility has been variably defined. Infertility affects approximately 80 million people from all parts of the world. An important area of discussion has been represented by the possible causal link between psychopathology and infertility. In the past, the prevalence of psychiatric problems among infertile couples was estimated to be 25-60%. The incidence of depression and anxiety in infertile couples is significantly high than in fertile controls and in the general population respectively. Infertility has been linked to obsessive-compulsive symptoms, psychoticism, substance abuse and eating disorders. Psychological impact of infertility is greater in women than in men. Additionally, authors found that infertile patients were more alexithymic than healthy controls. In relation to the different needs, different psychological therapeutic interventions may be indicated. Psychological counseling can provide valuable assistance in dealing with infertility treatments and their eventual failures.

  17. Unilateral adrenal tumor, erectile dysfunction and infertility in a patient with 21-hydroxylase deficiency: effects of glucocorticoid treatment and surgery.

    Science.gov (United States)

    Scaroni, C; Favia, G; Lumachi, F; Opocher, G; Bonanni, G; Mantero, F; Armanini, D

    2003-02-01

    In untreated congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21OHDS) the presence of adrenal and testicular tumors had been described; however little is known about the effect of the enzymatic defect on fertility in males. We studied a male adult patient affected by 21OHDS for infertility, after a long period of discontinuation of glucocorticoid therapy and then during resumption of treatment and 8 months after monoadrenalectomy. The initial spermatic count revealed azoospermia and testicular needle aspiration showed a cytological picture consistent with prepuberty. The morphofunctional study revealed a right adrenal mass with reduced uptake at radioscan. Treatment was resumed with onset of impotency, which improved after reduction of the dose of glucocorticoids. The patient was monoadrenalectomised and his spermatic count increased. The patient shows that corticosteroid therapy in 21OHDS should be continued lifelong to avoid adrenal hyperplasia with possible areas of autonomy and to allow regular fertility. Impotence during treatment is probably due to a decrease of excessive adrenal androgens while testicular androgen production is still suppressed.

  18. Endometriosis: Does It Cause Infertility?

    Science.gov (United States)

    ... Home FAQs Frequently Asked Questions Quick Facts About Infertility FAQs About Infertility FAQs About the Psychological Component of Infertility FAQs About Cloning and Stem Cell Research SART's ...

  19. Diagnostic Testing for Female Infertility

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  20. Infertility and Adenomyosis

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    Sebastiano Campo

    2012-01-01

    Full Text Available Classically, the diagnosis of adenomyosis has only been possible on a hysterectomy specimen, usually in women in their late fourth and fifth decades, and, therefore, evaluating any relationship with infertility was simply not possible. As a consequence, to this day, no epidemiologic data exists linking adenomyosis to a state of subfertility. Today, new imaging techniques have enabled a noninvasive diagnosis at a much earlier time and a number of single-case or small series reports have appeared showing that medical, surgical, or combined treatment can restore fertility in women with adenomyosis, an indirect proof of an association. At the functional level, several anomalies found in the so-called junctional zone, or inner myometrium, in adenomyosis patients have been shown to be associated with poor reproductive performance, mainly through perturbed uterine peristalsis. Additional evidence for an association comes from experimental data: in baboons, adenomyosis is associated with lifelong primary infertility, as well as to endometriosis. Finally, indirect proof comes from studies of the eutopic and ectopic endometrium in women with adenomyosis proving the existence of an altered endometrial function and receptivity. In conclusion, sufficient indirect proof exists linking adenomyosis to infertility to warrant systematic clinical studies.

  1. Tarlov cyst and infertility.

    Science.gov (United States)

    Singh, Pankaj Kumar; Singh, Vinay Kumar; Azam, Amir; Gupta, Sanjeev

    2009-01-01

    Tarlov cysts or spinal perineurial cysts are uncommon lesions. These are mostly incidental findings on magnetic resonance imaging or myelograms. The objectives of this study were to describe Tarlov cysts of the sacral region as a potential cause for retrograde ejaculations and review available management options. Case report and literature review. A 28-year-old man presented with back pain and retrograde ejaculations resulting in infertility. After microsurgical excision of large perineurial cysts, back pain resolved, but semen quality showed only marginal improvement. Later, the couple successfully conceived by intrauterine insemination. To the best of our knowledge, this is the first reported case of Tarlov cyst associated with retrograde ejaculation and infertility. Despite being mostly asymptomatic and an incidental finding, Tarlov cyst is an important clinical entity because of its tendency to increase in size with time. Tarlov cysts of the sacral and cauda equina region may be a rare underlying cause in otherwise unexplained retrograde ejaculations and infertility. Microsurgical excision may be a good option in a select group of patients.

  2. Testicular expression of survivin and human telomerase reverse transcriptase (hTERT) associated with spermatogenic function in infertile patients

    Institute of Scientific and Technical Information of China (English)

    Steffen Weikert; Frank Christoph; Wolfgang Schulze; Hans Krause; Carsten Kempkensteffen; Martin Schostak; Kurt Miller; Mark Schrader

    2006-01-01

    Aim: To characterize the coexpression of survivin, an inhibitor of apoptosis (IAF), and human telomerase reverse transcriptase (hTERT) in human testes with varying spermatogenic function. Methods: Transcript levels of survivin mRNA and hTERT mRNA were determined in normal testes (n = 11) and testes with defective spermatogenesis (n = 28) using real-time reverse-transcription polymerase chain reaction (RT-PCR). The histological work-up was performed according to a modified Johnsen score. Results: Expressions of both survivin and hTERT were highest at median levels of 96.8 and 709 in normal spermatogenesis and dropped to 53.3 and 534 in testes with postmeiotic spermatogenic arrest (n = 10). In severe spermatogenic failure (n = 18), survivin expression was lacking in most specimens (n = 16), whereas at least low levels of testicular hTERT expression were largely detectable with a normalized expression of 73 in premeiotic spermatogenic arrest (n = 7) and 45 in patients with Sertoli cell-only syndrome (SCOS)(n = 3). Both survivin and hTERT expressions increased with a progressing Johnsen score (P for trend = 0.001).Conclusion: Although both survivin and hTERT are correlated with spermatogenic function, they show different expression patterns in testes of infertile patients. These findings substantiate results from studies in the rodent testis suggesting a predominant expression of survivin in meiotically dividing germ cells.

  3. Patient predictors for outcome of gonadotrophin ovulation induction in women with normogonadotrophic anovulatory infertility: a meta-analysis

    NARCIS (Netherlands)

    J.S.E. Laven (Joop); M.J.C. Eijkemans (René); E.G. Hughes; B.C.J.M. Fauser (Bart); A.G.M.G.J. Mulders (Annemarie)

    2003-01-01

    textabstractA systematic review was conducted to determine whether initial screening characteristics of women with normogonadotrophic anovulatory infertility predict clinically significant outcomes of ovulation induction with gonadotrophins, and to obtain pooled estimates of their

  4. Preservation of sperm of cancer patients: extent of use and pregnancy outcome in a tertiary infertility center

    Institute of Scientific and Technical Information of China (English)

    Amnon Botchan; Shiri Karpol; Ofer Lehavi; Gedalia Paz; Sandra E Kleiman; Leah Yogev; Haim Yavetz

    2013-01-01

    Sperm cryopreservation is the best modality to ensure future fertility for males diagnosed with cancer.The extent to which cryopreserved sperm is actually used for impregnation,the fertility treatment options that are available and the success rates of these treatments have not been investigated in depth.The medical records of 682 patients who cryopreserved sperm cells due to cancer treatment were analyzed.Seventy of these patients withdrew their frozen sperm for fertility treatments over a 20-year period (most within the first 4 years after cryopreservation).Sperm quality of different malignancies and outcomes of assisted reproduction treatment (ART) for pregnancy achievement in relation to the type of treatment and the type of malignancy were evaluated.The results showed that the rate of using cryo-thawed sperm from cancer patients for fertility treatments in our unit was 10.3%.Sperm quality indices differed between different types of malignancies,with the poorest quality measured in testicular cancer.Conception was achieved in 46 of the 184 ART cycles (25%),and resulted in 36 deliveries.The use of intracytoplasmic sperm injection (ICSI)methodology yielded a significantly higher pregnancy rate (37.4%) than intrauterine insemination (IUI; 11.5%) and was similar to other groups of infertile couples using these modalities.In vitrofertilization (IVF) failed to produce pregnancies.In conclusion,the rate of use of cryopresseved sperm in cancer patients is relatively low (10.3%).Achievement of pregnancies by ICSI presents the best option but when there are enough stored sperm samples and adequate quality,IUI can be employed.Cryopreservation is nevertheless the best option to preserve future fertility potential and hope for cancer patients.

  5. Use of testicular sperm for ICSI in oligozoospermic couples: how far should we go?

    Science.gov (United States)

    Zini, Armand; Bach, Phil V; Al-Malki, Ahmad H; Schlegel, Peter N

    2017-01-01

    In 1992 and subsequently, several reports indicated that ICSI was a successful technique to achieve clinical pregnancy and live birth using spermatozoa with severely impaired characteristics. The initial optimism over the ability of ICSI to overcome significant sperm abnormalities was later tempered by the findings of more recent publications suggesting that some sperm deficits may not be as effectively treated with ICSI. In search for effective treatment for couples with severe male factor, a number of small retrospective and prospective studies have reported high pregnancy and live birth rates using testicular sperm for men with necrozoospermia, cryptozoospermia and oligozoospermia with or without elevated sperm DNA damage. Although the data suggest that there may be some benefit in performing testicular sperm retrieval (TSR)-ICSI in select groups of non-azoospermic infertile men, there are potential risks involved with TSR. Clinicians should balance these risks prior to the recommendation of TSR-ICSI on the result of a semen analysis or sperm DNA test alone. Careful evaluation and management of male factor infertility is important. The use of TSR-ICSI in the absence of specific sperm DNA defects is still experimental.

  6. THE SOCIAL AND CLINICAL CHARACTERISTIC OF PATIENTS WITH THE ISOLATED GENITAL TUBERCULOSIS ASSOCIATED WITH INFERTILITY, THE ACTIVE AND CLINICALLY CURED TUBERCULOSIS OF RESPIRATORY ORGANS IN COMBINATION WITH PREGNANCY

    Directory of Open Access Journals (Sweden)

    A. V. Mordyk

    2015-01-01

    Full Text Available Due to the high incidence of tuberculosis of women of reproductive age research at 270 patients was conducted. The group of research included women with infertility and genital tuberculosis, pregnant women with active tuberculosis of lungs, pregnant women with clinically cured tuberculosis of respiratory organs. Pregnant women with tuberculosis of lungs were more often from sociopathic families, had venereal diseases, HIV infection, hepatitises.

  7. Ultrasonographic and clinical correlates of seminal plasma interleukin-8 levels in patients attending an andrology clinic for infertility.

    Science.gov (United States)

    Lotti, F; Corona, G; Mancini, M; Filimberti, E; Degli Innocenti, S; Colpi, G M; Baldi, E; Noci, I; Forti, G; Adorini, L; Maggi, M

    2011-12-01

    This study was aimed at evaluating the association between seminal plasma interleukin-8 (sIL-8) and colour-Doppler ultrasound (CDU) characteristics of the male genital tract in a series of patients fulfilling the criteria of male accessory gland infections (MAGI). Of 250 subjects seeking medical care for couple infertility, 79 (mean age: 36.4 ± 7.5 years) met the criteria of MAGI and scored higher than the rest of the sample on the National Institutes of Health-Chronic Prostatitis Symptom Index score. All patients underwent simultaneous hormone evaluation and seminal analysis (including sIL-8), along with scrotal and transrectal CDU before and after ejaculation. After adjusting for age, sIL-8 in patients with MAGI was significantly related to several abnormal semen and CDU parameters. In particular, leucocytospermia was closely associated with sIL-8. Ejaculate volume, unlike other semen or hormonal parameters, was negatively associated with sIL-8. When scrotal CDU was performed, sIL-8 was positively related to CDU inhomogeneous, hypo-echoic, hyper-echoic epididymis and to epididymal calcifications. In addition, a positive correlation among sIL-8, hyperaemic epididymis and an increased size of epididymal tail was found. When transrectal CDU was performed, an association among sIL-8 and hyper-echoic seminal vesicles, dilated ejaculatory ducts and duct calcifications was also observed. Finally, sIL-8 was positively related to prostate CDU abnormalities such as calcifications, inhomogeneous/hypo-echoic texture, hyperaemia and high arterial blood flow. No association was found with testis parameters. In conclusion, sIL-8 levels in patients with MAGI are associated with several parameters and CDU abnormalities of epididymis, seminal vesicles, ejaculatory ducts and prostate, but not of the testis. Furthermore, sIL-8 positively correlates with CDU signs of ejaculatory duct inflammatory subobstruction.

  8. Experiencing Male Infertility

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    Esmée Hanna

    2015-10-01

    Full Text Available This article examines the qualitative research literature that exists in relation to men’s experiences of male infertility. Since men have often been marginalized in the realm of reproduction, including academic research on infertility, it is important to focus on any qualitative research that gives voices to male perspectives and concerns. Given the distress documented by studies of infertile women, we focus in particular on the emotive responses and lived experiences of men in relation to infertility. In this article then, we present an analysis of the core themes across 19 qualitative articles, which include “infertility as crisis”; “emoting infertility- men as “being strong”’ “infertility as a source of stigma”; and the “desire for fatherhood.” In light of these insights, we identify key areas for future research and development including men’s emotional responses to infertility, how men seek support for infertility, the intersection between masculinity and infertility, the relationship between the desire to father and infertility, and the outcomes of infertility for men in terms of other aspects of their lives. We suggest that such research would facilitate making the experiences of men more central within our understandings of infertility within a field that has primarily been female focused.

  9. Communication at an online infertility expert forum: provider responses to patient's emotional and informational cues.

    NARCIS (Netherlands)

    Aarts, J.W.M.; Oers, A.M.; Faber, M.J.; Cohlen, B.J.; Nelen, W.L.D.M.; Kremer, J.A.M.; Dulmen, A.M. van

    2015-01-01

    Online patient-provider communication has become increasingly popular in fertility care. However, it is not known to what extent patients express cues or concerns and how providers respond. In this study, we investigated cues and responses that occur in online patient-provider communication at an in

  10. Primary infertility (image)

    Science.gov (United States)

    Primary infertility is a term used to describe a couple that has never been able to conceive a pregnancy ... to do so through unprotected intercourse. Causes of infertility include a wide range of physical as well ...

  11. SERUM PROLACTIN ASSAY: AN IMPORTANT SCREENING METHOD IN PRIMARY AND SECONDARY INFERTILITY IN FEMALE

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    Sanjaya

    2016-02-01

    Full Text Available BACKGROUND Infertility represents a common condition nowadays with important medical, economic and psychological implications. Traditionally, measurement of Prolactin has been considered an important component of infertility workup in women. AIMS The study was designed to evaluate the serum prolactin assay in patients with primary and secondary infertility. METHOD In this retrospective case control study, we investigated one fifty (150 infertile women in the age range of 20-40 years attending Department of Obs. and Gynae. MLB Medical College, Jhansi, for infertility treatment. Fifty (50 fertile women with similar age range were selected as controls. The association between infertility and levels of serum Prolactin was reviewed. RESULTS Hyperprolactinemia was depicted in 24.66% infertile women. Prevalence of primary infertility was 68%, while that of secondary infertility cases was 32%. There was a correlation between Prolactin levels in infertile subjects (p <0.05. CONCLUSION There was higher prevalence of hyperprolactinemia in infertile patients

  12. Uterine adenomyosis in infertile patients: MR imaging findings and clinical conclusions; MRT der uterinen Adenomyose bei infertilen Patientinnen: Ergebnisse und klinische Rueckschluesse

    Energy Technology Data Exchange (ETDEWEB)

    Zangos, S.; Eichler, K.; Herzog, C.; Marquardt, F.; Peters, J.; Jacobi, V.; Mack, M.G.; Vogl, T.J. [Inst. fuer Diagnostische und Interventionelle Radiologie, J.W. Goethe-Univ. Frankfurt (Germany); Kissler, S.; Mueller, A.; Siebzehnruebl, E.; Kaufmann, M. [Klinik fuer Gynaekologie und Geburtshilfe, J. W. Goethe-Univ. Frankfurt (Germany); Hamscho, N.; Gruenwald, F. [Klinik fuer Nuklearmedizin, J. W. Goethe-Univ. Frankfurt (Germany)

    2004-11-01

    Purpose: To evaluate the clinical value of magnetic resonance imaging (MRI) of the uterus and the pelvis in infertile female with symptomatic endometriosis for the assessment of uterine morphology and function. Materials and Methods: Forty-one infertile women (mean age: 33.2 years) with symptomatic endometriosis documented by laparoscopy were evaluated with highfield MRI (Sonata, Siemens) using T2- and T1-weighted sequences. In addition, the patients underwent hysterosalpingoscintigraphy (HSSG) for evaluation of the uterotubal transport capacity. Pathologic findings of the uterine junction zone were correlated with the laparoscopic results, clinical symptoms and uterotubal transport capacity. Results: Adenomyosis was diagnosed on T2-weighted MR-images in 35 (85.4%) patients (focal adenomatosis in 26 patients and diffuse adenomatosis in 9). Patients showing signs of adenomyosis tended to be older than patients without adenomyosis (mean age 34.1 years vs. 30.1 years) and showed a longer history of symptomatic endometriosis. A positive transport capacity in HSSG was observed in 73.1% (19/26) of the patients with focal adenomyosis and only 22.2% (2/9) of patients with diffuse adenomyosis. In 83.3% (5/6) of the patients without signs of adenomyosis, a positive uterotubal transport was documented. Conclusion: MRI of the uterus is a helpful diagnostic tool for the diagnosis of adenomyosis and for planning further therapies. Patients with the diagnosis of adenomyosis showed a reduced uterotubal transport capacity that depended on the severity of adenomyotic changes and might be a possible cause of infertility. (orig.)

  13. A comparison of heterosexual and LGBTQ cancer survivors' outlooks on relationships, family building, possible infertility, and patient-doctor fertility risk communication.

    Science.gov (United States)

    M Russell, Andrea; Galvin, Kathleen M; Harper, Maya M; Clayman, Marla L

    2016-10-01

    Little research about cancer-related infertility has examined the experiences and needs of lesbian, gay, bisexual, transgender, or queer (LGBTQ) cancer survivors. This research seeks to understand how LGBTQ survivors are similar to or different from heterosexual survivors with respect to cancer treatments' effects on relationships, plans for parenthood, and fertility preservation decision making. Semi-structured telephone interviews conducted with adolescent or young adult (AYA) cancer survivors (n = 56) were coded for themes. Interviews consisted of questions about pre- and post-diagnosis thoughts about relationships, parenthood, possible infertility, and how information about fertility risks was received. While LGBTQ (n = 22) and heterosexual (n = 34) survivors reported similar challenges when dating post-diagnosis, heterosexual survivors were more likely to report fertility concerns as affecting romantic relationships (p LGBTQ survivors seemed more open to raising non-biological children or not becoming a parent than heterosexual survivors. LGBTQ survivors generally reported being satisfied with or indifferent to the information that they were given regarding fertility loss, despite reporting receiving similar amounts of information as compared to heterosexual patients (p LGBTQ patients' views on relationships, parenthood, and family building seemed to result in less distress when faced with infertility. However, interventions facilitating information exchange about dating, fertility risks, and family building options may be valuable to LGBTQ and heterosexual cancer survivors. LGBTQ cancer survivors may display more adaptive coping with respect to relationships and fertility loss. Oncology professionals may want to proactively introduce positive coping strategies to reduce distress among AYA cancer survivors at risk for infertility.

  14. Immune Aspects of Female Infertility

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    Andrea Brazdova

    2016-05-01

    Full Text Available Immune infertility, in terms of reproductive failure, has become a serious health issue involving approximately 1 out of 5 couples at reproductive age. Semen that is defined as a complex fluid containing sperm, cellular vesicles and other cells and components, could sensitize the female genital tract. The immune rejection of male semen in the female reproductive tract is explained as the failure of natural tolerance leading to local and/or systemic immune response. Present active immune mechanism may induce high levels of anti-seminal/sperm antibodies. It has already been proven that iso-immunization is associated with infertility. Comprehensive studies with regards to the identification of antibody-targets and the determination of specific antibody class contribute to the development of effective immuno-therapy and, on the other hand, potential immuno-contraception, and then of course to complex patient diagnosis. This review summarizes the aspects of female immune infertility.

  15. Predictors of patients remaining anovulatory during clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility

    NARCIS (Netherlands)

    B. Imani (Babak); M.J.C. Eijkemans (René); E.R. te Velde (Egbert); J.D.F. Habbema (Dik); B.C.J.M. Fauser (Bart)

    1998-01-01

    textabstractThe diagnostic criteria used to identify patients suffering from polycystic ovary syndrome remain controversial. The present prospective longitudinal follow-up study was designed to identify whether certain criteria assessed during standardized initial scree

  16. Predictors of patients remaining anovulatory during clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility

    NARCIS (Netherlands)

    B. Imani (Babak); M.J.C. Eijkemans (René); E.R. te Velde (Egbert); J.D.F. Habbema (Dik); B.C.J.M. Fauser (Bart)

    1998-01-01

    textabstractThe diagnostic criteria used to identify patients suffering from polycystic ovary syndrome remain controversial. The present prospective longitudinal follow-up study was designed to identify whether certain criteria assessed during standardized initial

  17. Reproductive Outcome after Hysteroscopic Metroplasty in Patients with Infertility and Recurrent Pregnancy Loss

    OpenAIRE

    Gligor Tofoski; Jadranka Georgievska

    2014-01-01

    Introduction: Reproductive outcome can be negatively affected in patients with congenital uterine anomalies (CUA), increasing the number of unsuccessful pregnancies and obstetric complications. Compared with the population with normally formed uterus, patients with CUA have higher abortion rate, higher fetal loss rate and decreased live birth rate. Hysteroscopic metroplasty (HM) is a standard, safe and minimally invasive method for the treatment of correctible types of congenital uterine anom...

  18. Exploration of Infertile Couples’ Support Requirements: A Qualitative Study

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    Fatemeh Jafarzadeh-Kenarsari

    2015-04-01

    Full Text Available Background: Due to high prevalence of infertility, increasing demand for infertility treatment, and provision of high quality of fertility care, it is necessary for healthcare professionals to explore infertile couples’ expectations and needs. Identification of these needs can be a prerequisite to plan the effective supportive interventions. The current study was, therefore, conducted in an attempt to explore and to understand infertile couples’ experiences and needs. Materials and Methods: This is a qualitative study based on a content analysis approach. The participants included 26 infertile couples (17 men and 26 women and 7 members of medical personnel (3 gynecologists and 4 midwives as the key informants. The infertile couples were selected from patients attending public and private infertility treatment centers and private offices of infertility specialists in Isfahan and Rasht, Iran, during 2012-2013. They were selected through purposive sampling method with maximum variation. In-depth unstructured interviews and field notes were used for data gathering among infertile couples. The data from medical personnel was collected through semi-structured interviews. The interview data were analyzed using conventional content analysis method. Results: Data analysis revealed four main categories of infertile couples’ needs, including: i. Infertility and social support, ii. Infertility and financial support, iii. Infertility and spiritual support and iv. Infertility and informational support. The main theme of all these categories was assistance and support. Conclusion: The study showed that in addition to treatment and medical needs, infertile couples encounter various challenges in different emotional, psychosocial, communicative, cognitive, spiritual, and economic aspects that can affect various areas of their life and lead to new concerns, problems, and demands. Thus, addressing infertile couples’ needs and expectations alongside their

  19. Hysteroscopic evaluation of post abortive infertile females

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    Ehab Elhelw

    2016-09-01

    Full Text Available Objectives: To study the hysteroscopic findings in cases of secondary infertility following abortion compared to cases with primary infertility. Methods: This was a case control study of 200 selected infertile women undergoing diagnostic hysteroscopy as a part of their infertility work-up. These 200 patient were classified into the following: A – 100 patients in whom abortion has occurred whether evacuation and curettage (E.&C. was done or not and B – 100 patients complaining of primary infertility. Results: Hysteroscopy was normal in about 44% of patients group and 45% in control group. Observed abnormalities were septate uterus in 17 cases, intrauterine synechiae in 30 cases, submucus myoma in 10 cases, deformed cavity in 5 cases and endometrial polyp in 35 cases. Endometrial abnormalities (fibrosis, inflammation or atrophy were observed in 7 patients. No significance was found regarding the total number of intrauterine pathologies when comparing the groups of primary versus secondary infertility. Patients group showed higher prevalence of Intra Uterine Septum and Intra Uterine Adhesions. Control group showed higher prevalence of endometrial polyp, submucous myoma and Endometritis. Other findings showed nearly equal prevalence in the two groups. Conclusion: There is a direct correlation between the number of abortions, number of evacuations (E.&C. and degree of intra-uterine adhesion, and an increase in the number of abortions is associated with an increase in the degree of intra-uterine adhesions. However, in this study, there was no significant difference between degree of intra-uterine adhesions in the two groups (patient group and control group. Our data are an additional argument to suggest hysteroscopy as part of investigation in infertile woman. Routine diagnostic hysteroscopy should be part of an infertility work-up in primary and secondary infertility.

  20. Bacteriospermia and Sperm Quality in Infertile Male Patient at University of Benin Teaching Hospital, Benin City, Nigeria

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    Ibadin, O. K.

    2008-01-01

    Full Text Available Male Urogenital tract infection plays an important role in men infertility. Asymptomtic bacteriospermia has been regarded as of the contributing factor to male infertility. In this study, 87 semen samples of infertile men attending the Human Reproduction Research Programme and Invitrofertilization unit (HRRP/IVF of University Benin Teaching Hospital were evaluated Bacteriologically using standard Bacterial culture method. Standard semen analysis was performed according to WHO guidelines. Among the total cases, 36 (41.4% showed at least one pathogen. Staphylococcus aureus (16.1%, Staphylococcus Saprophyticus (9.1%, Escherichia Coli (6.9% Proteus mirabilis (3.4% Klebsiella spp (2.3% Pseudomonas aerouginosa (1.1% and Proteus vulgaris (2.3%. There was a significant relation between bacteriospermia and the rate of number of total motility and morphologically abnormal sperms (p 0.05. It seems that leukocytopermia is not a good maker to predict bacteriospermia.

  1. General aspects of fertility and infertility.

    Science.gov (United States)

    Damario, Mark A

    2014-01-01

    Fertility rates have been declining in most Western nations over the past several decades, although it is not entirely clear if an increased rate of infertility substantially contributes to this. As compared to other species, the reproductive efficiency of humans is relatively low. Factors related to fertility include age, exposure to sexually transmitted diseases, frequency of intercourse, coital timing, as well as diet and lifestyle habits. Infertility is considered a disease due to its major disruption of major organ systems and life functions. An infertility evaluation is recommended after 12 months or more of regular, unprotected intercourse and may be considered after 6 months for those female patients over the age of 35 or with other known abnormalities. A proper infertility evaluation is a comprehensive examination of possibly identifiable infertility factors of both female and male partners, lending itself to the most appropriate and potentially effective treatment.

  2. Quality indicators for all dimensions of infertility care quality: consensus between professionals and patients

    NARCIS (Netherlands)

    Dancet, E.A.; D'Hooghe, T.M.; Spiessens, C.; Sermeus, W.; Neubourg, D. De; Karel, N.; Kremer, J.A.M.; Nelen, W.L.D.M.

    2013-01-01

    STUDY QUESTION: What is the relative importance of the six dimensions of quality of care according to different stakeholders and can a quality indicator set address all six quality dimensions and incorporate the views from professionals working in different disciplines and from patients? SUMMARY ANS

  3. Analysis of chromosome karyotypeamong 1 22 infertile males patients%122例男性不育患者染色体核型分析

    Institute of Scientific and Technical Information of China (English)

    周伟; 李新伟; 张群芝

    2015-01-01

    目的:对男性不育患者进行染色体核型的检测,探讨男性不育与染色体核型异常的关系。方法:按常规方法制作染色体标本的方法,对122例男性不育患者进行核型分析。结果:共检出染色体异常17例,异常率为13.93%。其中性染色体异常12例,占男性不育患者的9.84%,常染色体异常5例,占男性不育患者的4.10%。在所有的核型中,Klinefelter 综合征的发生率最高,占异常核型的23.53%。结论:染色体异常是导致男性不育的重要原因之一,染色体核型分析对男性不育患者的诊断和治疗具有重要的指导意义。%Objectives:To analyze the karyotypes of infertile male patients so as to investigate the relation-ship between male infertility and chromosome abnormalities.Methods:The chromosome karyotypes of 1 22 male in-fertile patients were analyzed by routinely cultured peripheral blood lymphocytes.Results:There were 1 7 cases of abnormal karyotypes which accounted for 1 3.93%,including 1 2 (9.84%)cases of sex abnormal karyotype and 5 (4.1 0%)cases of autosome abnormal karyotype.The klinefelter syndrome was the most common disease caused by abnormal karyotype and the ratio was 23.53% in all the abnormal karyotypes.Conclusion:Chromosome abnormali-ty is an important cause of male infertility.Karyotype analysis is important for the diagnosis and treatment of male infertility.

  4. Management of primary ciliary dyskinesia/Kartagener's syndrome in infertile male patients and current progress in defining the underlying genetic mechanism

    Directory of Open Access Journals (Sweden)

    Yan-Wei Sha

    2014-02-01

    Full Text Available Kartagener's syndrome (KS is an autosomal recessive genetic disease accounting for approximately 50% of the cases of primary ciliary dyskinesia (PCD. As it is accompanied by many complications, PCD/KS severely affects the patient's quality of life. Therapeutic approaches for PCD/KS aim to enhance prevention, facilitate rapid definitive diagnosis, avoid misdiagnosis, maintain active treatment, control infection and postpone the development of lesions. In male patients, sperm flagella may show impairment in or complete absence of the ability to swing, which ultimately results in male infertility. Assisted reproductive technology will certainly benefit such patients. For PCD/KS patients with completely immotile sperm, intracytoplasmic sperm injection may be very important and even indispensable. Considering the number of PCD/KS susceptibility genes and mutations that are being identified, more extensive genetic screening is indispensable in patients with these diseases. Moreover, further studies into the potential molecular mechanisms of these diseases are required. In this review, we summarize the available information on various aspects of this disease in order to delineate the therapeutic objectives more clearly, and clarify the efficacy of assisted reproductive technology as a means of treatment for patients with PCD/KS-associated infertility.

  5. Evaluation and treatment of infertility.

    Science.gov (United States)

    Lindsay, Tammy J; Vitrikas, Kristen R

    2015-03-01

    Infertility is defined as the inability to achieve pregnancy after one year of regular, unprotected intercourse. Evaluation may be initiated sooner in patients who have risk factors for infertility or if the female partner is older than 35 years. Causes of infertility include male factors, ovulatory dysfunction, uterine abnormalities, tubal obstruction, peritoneal factors, or cervical factors. A history and physical examination can help direct the evaluation. Men should undergo evaluation with a semen analysis. Abnormalities of sperm may be treated with gonadotropin therapy, intrauterine insemination, or in vitro fertilization. Ovulation should be documented by serum progesterone level measurement at cycle day 21. Evaluation of the uterus and fallopian tubes can be performed by hysterosalpingography in women with no risk of obstruction. For patients with a history of endometriosis, pelvic infections, or ectopic pregnancy, evaluation with hysteroscopy or laparoscopy is recommended. Women with anovulation may be treated in the primary care setting with clomiphene to induce ovulation. Treatment of tubal obstruction generally requires referral for subspecialty care. Unexplained infertility in women or men may be managed with another year of unprotected intercourse, or may proceed to assisted reproductive technologies, such as intrauterine insemination or in vitro fertilization.

  6. Psychosocial Consequences of Infertility on Infertile Women.

    Science.gov (United States)

    Fatima, P; Rahman, D; Hossain, H B; Hossain, H N; Mughi, C R

    2015-10-01

    This study explores to find out the qualitative and quantitative psychosocial consequences of infertility in women coming for infertility treatment in tertiary infertility center. A total of 400 infertile couples who agreed to participate in the study were asked to fill up the questionnaires and later interviewed to access the psychosocial consequences of infertility on their personal life in a tertiary infertility clinic in Dhaka at Center for Assisted Reproduction (CARe Hospital), Dhaka from June 2011 to December 2011 and agreed to participate in the study were included in the study. The data was analyzed and the quantitative and qualitative psychosocial factors were evaluated. Four hundred infertile couple who filled the questionnaires was included in the study. Sixty three percent of the women belonged to age group >20 30 years at the time of interview. Regarding age at marriage 43.8% of the women were married by 20 years, 51.3% were married between 20 30 years. Mean±SD duration of present married life was 7.20±4.45 (range 1 to 28) years and 74.4% of the women were living with their husbands. Of them 75.5% women were housewife. When asked whether they knew what was the reason of infertility in the couple, 32.5% knew the cause was in the female partner, 14.5%, knew the cause was in the male partner, 10.3% knew the cause was in both partners, 21.5% knew cause of infertility was not in any of the partners, and 21.3% had no idea about the cause of infertility. The male partner's response about the issue of prognosis and outcome of couple's infertility revealed 37.3% believed their wives will conceive someday, 31.3% had no intention for a second marriage, 13% were indifferent, 11.3% blamed their wives for infertility and 4.8% threatened for a second marriage. Only 2.5% of the male partners were suggested on consulting and continuing treatment by specialist. The family pressure by in-laws and relatives towards their infertility was that 57.3% insisted on consulting

  7. Out-of-pocket fertility patient expense: data from a multicenter prospective infertility cohort.

    Science.gov (United States)

    Wu, Alex K; Odisho, Anobel Y; Washington, Samuel L; Katz, Patricia P; Smith, James F

    2014-02-01

    The high costs of fertility care may deter couples from seeking care. Urologists often are asked about the costs of these treatments. To our knowledge previous studies have not addressed the direct out-of-pocket costs to couples. We characterized these expenses in patients seeking fertility care. Couples were prospectively recruited from 8 community and academic reproductive endocrinology clinics. Each participating couple completed face-to-face or telephone interviews and cost diaries at study enrollment, and 4, 10 and 18 months of care. We determined overall out-of-pocket costs, in addition to relationships between out-of-pocket costs and treatment type, clinical outcomes and socioeconomic characteristics on multivariate linear regression analysis. A total of 332 couples completed cost diaries and had data available on treatment and outcomes. Average age was 36.8 and 35.6 years in men and women, respectively. Of this cohort 19% received noncycle based therapy, 4% used ovulation induction medication only, 22% underwent intrauterine insemination and 55% underwent in vitro fertilization. The median overall out-of-pocket expense was $5,338 (IQR 1,197-19,840). Couples using medication only had the lowest median out-of-pocket expenses at $912 while those using in vitro fertilization had the highest at $19,234. After multivariate adjustment the out-of-pocket expense was not significantly associated with successful pregnancy. On multivariate analysis couples treated with in vitro fertilization spent an average of $15,435 more than those treated with intrauterine insemination. Couples spent about $6,955 for each additional in vitro fertilization cycle. These data provide real-world estimates of out-of-pocket costs, which can be used to help couples plan for expenses that they may incur with treatment. Copyright © 2014 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  8. Two cases of Robertsonian translocations in oligozoospermic males and their consequences for pregnancies induced by intracytoplasmic sperm injection

    NARCIS (Netherlands)

    R.F.A. Weber (Robert); F.J. Los; N.S. den Hollander (Nicolette); M. Dhont; M.H. Pieters; J.O. van Hemel; P.A. in 't Veld

    1997-01-01

    textabstractTwo case histories are presented documenting structural chromosome abnormalities in infertile males. The abnormalities were detected only after application of intracytoplasmic sperm injection (ICSI) was repeatedly unsuccessful or resulted in an abnormal preg

  9. Two cases of Robertsonian translocations in oligozoospermic males and their consequences for pregnancies induced by intracytoplasmic sperm injection

    NARCIS (Netherlands)

    P.A. In't Veld (Peter); R.F.A. Weber (Rob); F.J. Los; N.S. den Hollander (Nicolette); M. Dhont; M.H.E.C. Pieters (Math H. E.); J.O.V. Hemel (Jan O. Van)

    1997-01-01

    textabstractTwo case histories are presented documenting structural chromosome abnormalities in infertile males. The abnormalities were detected only after application of intracytoplasmic sperm injection (ICSI) was repeatedly unsuccessful or resulted in an abnormal pregnancy. A mosaic Robertsonian t

  10. Two cases of Robertsonian translocations in oligozoospermic males and their consequences for pregnancies induced by intracytoplasmic sperm injection

    NARCIS (Netherlands)

    R.F.A. Weber (Robert); F.J. Los; N.S. den Hollander (Nicolette); M. Dhont; M.H. Pieters; J.O. van Hemel; P.A. in 't Veld

    1997-01-01

    textabstractTwo case histories are presented documenting structural chromosome abnormalities in infertile males. The abnormalities were detected only after application of intracytoplasmic sperm injection (ICSI) was repeatedly unsuccessful or resulted in an abnormal preg

  11. Real emotional experience of male infertile patients:a qualitative study%男性不育症患者情感体验的质性研究

    Institute of Scientific and Technical Information of China (English)

    邓桂英; 王文兰; 欧阳结颜; 李彩英

    2013-01-01

    目的探讨男性不育症患者情感体验,为指导护士实施心理疏导提供依据。方法采用深度访谈法收集8例不育症男性患者资料,采用现象学分析法进行分析描述,了解男性不育症患者真实情感体验。结果不育症患者情感体验主要有5个主题:否认与焦虑,痛苦与接受,羞愧与孤立,哀伤与无价值感,性功能紊乱。结论不育症患者内心深处情感体验复杂,医护人员应主动了解不育症患者的负性情感,给予有效的正向情感引导,并尽可能提供完善的社会支持,使其尽快摆脱不育的阴霾。%Objective To investigate the real emotional experience of the male infertile patients.Method The clinical data of 8 male infertile patients were collected by in-depth interview and analyzed by phenomenologic analysis to investigate their real emotional experience.Result Five themes in related to their emotional experience were concluded,including denial and anxiety, pain and acceptance,shame and isolation,senses of sadness and worthlessness and sexual dysfunction.Conclusions Infertile patients have complex emotional experience deep in their heart.Therefore,the medical staff should take the initiative to understand negative emotions,give effective guidance of positive emotions and provide comprehensive social supports.

  12. Effectiveness of highly purified urofollitropin treatment in patients with idiopathic azoospermia before testicular sperm extraction.

    Science.gov (United States)

    Cocci, Andrea; Cito, Gianmartin; Russo, Giorgio I; Falcone, Marco; Capece, Marco; Timpano, Massimiliano; Della Camera, Pier Andrea; Morselli, Simone; Tasso, Giovanni; Morelli, Girolamo; Morgia, Giuseppe; Minervini, Andrea; Serni, Sergio; Carini, Marco; Natali, Alessandro; Gacci, Mauro

    2017-08-07

    Recent evidences demonstrated that male factor alone is responsible for about 30% cases of infertility. Human follicle-stimulating hormone (hFSH) has been introduced to increase sperm concentration, spermatogonial population, or both natural or assisted pregnancy rates (PRs) in oligozoospermic subjects with normal concentrations of gonadotropins. Fifty infertile men affected by idiopathic azoospermia were enrolled in this study, after undergoing medical history, physical and clinical examination, baseline semen parameters and hormonal plasma concentrations. Inclusion criteria were infertility for at least 2 years, idiopathic azoospermia, FSH <12 mIU/ml. Twenty-five patients were allocated to treatment with hFSH three times/week per 3 months (Fostimon), and 25 patients underwent just testicular sperm extraction (TESE) without medical treatment. All patients underwent, after 3 months, assisted reproduction techniques (ARTs) with TESE. The primary outcome was represented by the differences in the sperm retrieval rate (SRR) between groups, while the secondary outcomes were the differences in PR and fertilization rate (FR). We observed a PR of 15% (3/25) and 28% (7/25) in control and treated group, respectively. SRR after medical treatment and ART was 24% (6/25), while in the control group was 12.5% (2/25). The sperm in the ejaculate of five patients (20%) after medical treatment exhibited a mean concentration of 0.9 million/ml and a mean motility of 12%. The FR was significantly greater in the treatment group with respect to the control group, 30% and 20%, respectively. FSH treatment showed greater efficacy rather than control by increasing the rate of PR and FR in azoospermic patients who underwent TESE.

  13. Cigarette smoking and male infertility

    Directory of Open Access Journals (Sweden)

    Taymour Mostafa

    2010-07-01

    Full Text Available Numerous studies have identified specific body systems affected by the hazardous effects of the cigarette smoking particularly the respiratory and cardiovascular systems. The effect of smoking on male reproduction has also been studied where semen quality was investigated in different cross-sectional studies including infertile patients with conflicting results. This article aimed to assess the relationship between smoking and male infertility. A review of published articles was carried out, using PubMed, medical subject heading (MSH databases and Scopus engine excluding the effects of smoking outside male infertility. Key words used to assess exposure, outcome, and estimates for the concerned associations were: smoking, semen, male infertility, sperm, humans, and fertility. Most of the reports showed that smoking reduces sperm production, sperm motility, sperm normal forms and sperm fertilising capacity through increased seminal oxidative stress and DNA damage. Few papers reported nonsignificant differences in semen parameters between smokers or non-smokers. It is concluded that although some smokers may not experience reduced fertility, men with marginal semen quality can benefit from quitting smoking.

  14. Use of the internet related to infertility by infertile women and men in Turkey.

    Science.gov (United States)

    Satir, Duygu Gulec; Kavlak, Oya

    2017-01-01

    To determine differences in use of the Internet related to infertility between infertile women and men, whether they benefit or are negatively affected from information on the Internet, and share this information with health professional. This cross-sectional study was carried out with 285 infertile women and 158 men between December 2015 and February 2016. Data were collected by a survey Form which included questions related to sociodemographic characteristics, related to infertility (duration of treatment, type of treatment) and questions about use of the Internet. Chi-square analysis was used to evaluate the differences in Internet use and independent variables for patients. Seventy-four percent of women and 68.4% of men used the Internet related to infertility. Women and men most often looked for information related to assisted reproductive technology and the causes of infertility. Men searched for information related to fertility drugs used in treatment significantly less than women. They often visited the websites of fertility centers and doctors. A high percentage of them have benefited from information on the Internet. Almost half of the women and men shared the information obtained from the Internet with health professional. Most frequently, infertile patients use the Internet to obtain information related to infertility and they benefited from information on the Internet. For health professional it is important to direct Internet users to safe and true information resources.

  15. VALUE OF DIAGNOSTIC HYSTEROSCOPY IN INFERTILITY AS FIRST LINE INVESTIGATION

    Directory of Open Access Journals (Sweden)

    Vidya

    2013-01-01

    Full Text Available ABSTRACT: AIM OF THE STUDY: To evaluate the value of Diagnostic Hysteroscopy in a primary work-up of infertility To compare its use in primary versus secondary infert ility MATERIAL & METHODS: Prospective study from Jan 2012 – Oct 2012 at Radha krishna Multispecialty Hospital and IVF centre, Girinagar ,B angalore INCLUSION CRITERIA: Both primary and secondary infertile women A Total No. of patients – 170 (110 primary infertilit y & 60 secondary infertility were studied Intervention Office Hysteroscopy Main outcome measure Abnormalities of uterine cavity RESULTS: 30 %( n=51 of the total infertile patients studied had uterine a bnormalities .34% (n=37 of primary infertility patients had uterine ab normalities whereas 23 %( n=14 of secondary infertility patients also had uterine abno rmalities. The acquired and congenital causes for uterine abnormalities accounted for 20 % ( n=22 and 14% (n=15 respectively in the primary infertility group whereas it accounted for 17 %( n=10 and 6% (n=4 respectively in the secondary infertility group CONCLUSION: Routine use of diagnostic hysteroscopy in the work-up of infertility is recommended. Diagnostic hysteroscopy has a similar importance in the evaluation of both primary and secondary infertility

  16. Correlation between Chlamydia and Mycoplasma infections, cytokines level and the male infertility%衣原体属与支原体属感染及细胞因子水平和男性不育的相关性研究

    Institute of Scientific and Technical Information of China (English)

    刘燕婕; 周慧

    2013-01-01

    OBJECTIVE To explore the correlation between Chlamydia trachomatis (Ct),Ureaplasma urealyticum (Uu) infections,the cytokine level and the male infertility so as to analyze the causes of male infertility.METHODS According to the standard of WHO,the routine semen analysis,Ct antigen and Uu culture were performed for the fertile group and the infertile group.ELISA experiment was used to detect IL-2,IL-6,IL-8 and TNF-α in seminal plasma.RESULTS The infection rates of Ct,Uu and mixed Ct+Uu were significantly higher in the infertile group than in the fertile group (P<0.05).The incidence rate of Ct infections was 27.78% in the oligozoospermic group,28.20% in the asthenozoospermia group,and 26.83% in the azoospermia group; the incidence rate of Uu infections was 41.67% in the oligozoospermic group,43.59% in the asthenozoospermia group,and 46.34% in the azoospermia group; in the fertile group,the incidence rate of Ct infections was 5.71%,Uu infections 8.57%,the difference was significant (P<0.05).In the infertile group,the level of IL-2,IL-6,IL-8,or TNF alpha was significantly higher in the patients with Uu or Ct infections than in the patients without Uu or Ct infection (P<0.05).Compared with the fertile group,the level of IL-2,IL-6,IL-8,or TNF alpha in the oligozoospermic group or the azoospermia group was increased significantly (P<0.05).The difference in the level of IL-2 or TNF-αbetween the fertile group and the asthenozoospermia group was not significant,and the difference in the level of IL-6 or IL-8 between the asthenozoospermia group and the fertile group was significant (P<0.05).CONCLUSION The Ct or Uu infections in the genital tract of the male is closely related to the male infertility,and the infertility caused by infections may be related to the immune response involved in the cytokines.%目的 探讨男性不育症患者精液沙眼衣原体(Ct)、解脲脲支原体(Uu)感染与细胞因子水平的相关性,

  17. Genetic dosage and position effect of small supernumerary marker chromosome (sSMC) in human sperm nuclei in infertile male patient.

    Science.gov (United States)

    Olszewska, Marta; Wanowska, Elzbieta; Kishore, Archana; Huleyuk, Nataliya; Georgiadis, Andrew P; Yatsenko, Alexander N; Mikula, Mariya; Zastavna, Danuta; Wiland, Ewa; Kurpisz, Maciej

    2015-11-30

    Chromosomes occupy specific distinct areas in the nucleus of the sperm cell that may be altered in males with disrupted spermatogenesis. Here, we present alterations in the positioning of the human chromosomes 15, 18, X and Y between spermatozoa with the small supernumerary marker chromosome (sSMC; sSMC(+)) and spermatozoa with normal chromosome complement (sSMC(-)), for the first time described in the same ejaculate of an infertile, phenotypically normal male patient. Using classical and confocal fluorescent microscopy, the nuclear colocalization of chromosomes 15 and sSMC was analyzed. The molecular cytogenetic characteristics of sSMC delineated the karyotype as 47,XY,+der(15)(pter->p11.2::q11.1->q11.2::p11.2->pter)mat. Analysis of meiotic segregation showed a 1:1 ratio of sSMC(+) to sSMC(-) spermatozoa, while evaluation of sperm aneuploidy status indicated an increased level of chromosome 13, 18, 21 and 22 disomy, up to 7 × (2.7 - 15.1). Sperm chromatin integrity assessment did not reveal any increase in deprotamination in the patient's sperm chromatin. Importantly, we found significant repositioning of chromosomes X and Y towards the nuclear periphery, where both chromosomes were localized in close proximity to the sSMC. This suggests the possible influence of sSMC/XY colocalization on meiotic chromosome division, resulting in abnormal chromosome segregation, and leading to male infertility in the patient.

  18. Structured exercise training programme versus hypocaloric hyperproteic diet in obese polycystic ovary syndrome patients with anovulatory infertility: a 24-week pilot study.

    Science.gov (United States)

    Palomba, S; Giallauria, F; Falbo, A; Russo, T; Oppedisano, R; Tolino, A; Colao, A; Vigorito, C; Zullo, F; Orio, F

    2008-03-01

    Lifestyle modifications are successfully employed to treat obese and overweight women with polycystic ovary syndrome (PCOS). The aims of the current pilot study were (i) to compare the efficacy on reproductive functions of a structured exercise training (SET) programme with a diet programme in obese PCOS patients and (ii) to study their clinical, hormonal and metabolic effects to elucidate potentially different mechanisms of action. Forty obese PCOS patients with anovulatory infertility underwent a SET programme (SET group, n = 20) and a hypocaloric hyperproteic diet (diet group, n = 20). Clinical, hormonal and metabolic data were assessed at baseline, and at 12- and 24-week follow-ups. Primary endpoint was cumulative pregnancy rate. The two groups had similar demographic, anthropometric and biochemical parameters. After intervention, a significant improvement in menstrual cycles and fertility was noted in both groups, with no differences between groups. The frequency of menses and the ovulation rate were significantly (P diet group but the increased cumulative pregnancy rate was not significant. Body weight, body mass index, waist circumference, insulin resistance indexes and serum levels of sex hormone-binding globulin, androstenedione and dehydroepiandrosterone sulphate changed significantly (P diet interventions improve fertility in obese PCOS patients with anovulatory infertility. We hypothesize that in both interventions an improvement in insulin sensitivity is the pivotal factor involved in the restoration of ovarian function but potentially acting through different mechanisms.

  19. Etiological Analysis of 132 Patients with Secondary Infertility%132例继发性不孕患者病因分析

    Institute of Scientific and Technical Information of China (English)

    马新茹

    2012-01-01

    Objective To analyze the etiology of secondary infertility and to explore the effective clinical preventive measures. Methods One hundred and thirty - two patients with secondary infertility hospitalized in Maternal and Child Health Hospital of Qingyuan County from February 2010 to October 2011 were selected as the observation group, and 130 patients without infertility problems were simultaneously served as the control group. The menstrual hygiene, abortion history, endocrine disorders, ovarian dysfunction and sexually transmitted diseases were analyzed whether or not to be the risk factors for secondary infertility. Results The proportions of patients with the history of induced abortion, endocrine disorders, ovarian dysfunction and sexually transmitted diseases in the observation group were 44.7%, 27.3%, 31.1% and 21.2% respectively, which were significantly higher than those (10.8% , 14.6%, 15.4%, and 11.5%) of the control group. There were statistically significant differences between the two groups (P<0.05). The above four items were the risk factors for secondary infertility. Conclusions Clinical health- care workers should know about the risk factors of secondary infertility and take appropriate preventive measures targeted to the causes so as to reduce the incidence of the disease.%目的 分析继发性不孕患者病因并探讨有效的临床预防措施. 方法 选择2010年2月- 2011年10月在本院诊治的继发性不孕患者132例作为观察组,并选择同期来医院就诊的非不孕患者130例作为对照组,分析经期卫生、人工流产史、内分泌失调、卵巢功能障碍以及性传播疾病是否为继发性不孕发生的危险因素. 结果 观察组患者有人工流产史、内分泌失调、卵巢功能障碍以及性传播疾病的患者比例分别为44.7%、27.3%、31.1%、21.2%,均明显高于对照组的10.8%、14.6%、15.4%、11.5%,组间差异均有统计学意义(P<0.05),以上各项为继发性

  20. Hysterosalpingographic findings in infertility

    Energy Technology Data Exchange (ETDEWEB)

    Park, M. S.; Kim, K. S.; Kim, J. S.; Bai, B. C. [Seoul Red Cross Hospital, Seoul (Korea, Republic of)

    1981-12-15

    Four hundred and fifty four cases of H.S.G. in infertility were analyzed and following brief results were obtained. 1. Most frequent age group was 25-29 year old, and those number of patient were 188 (41.4%). 2. Most frequent abnormal uterine findings was intravasation (113 cases), and malposition (119), irregular margin (104), filling defect (37), and diverticulum (6) in decreasing order. 3. Most frequent abnormal tubal finding was obstruction (199 cases), and hydrosalpinx (99), diverticulosis (22), intravasation (17), peritubal adhesion (13), and beaded tube (10) in decreasing order. 4. Nagative findings was seen in 155 cases (34.1%) of uterus and in 227 cases (50.0%) of fallopian tubes. 5. Nagative findings in both uterus and fallopian tubes was seen only 87 cases (19.2%)

  1. Small Supernumerary Marker Chromosomes in Human Infertility.

    Science.gov (United States)

    Armanet, Narjes; Tosca, Lucie; Brisset, Sophie; Liehr, Thomas; Tachdjian, Gérard

    2015-01-01

    Small supernumerary marker chromosomes (sSMC) are structurally abnormal chromosomes that cannot be unambiguously identified by banding cytogenetics. The objective of this study was to provide an overview of sSMC frequency and characterization in a context of infertility and to review the literature describing sSMC in relation with male and female infertility. Therefore, a systematic literature review on sSMC associated with infertility was conducted by means of a PubMed literature and a sSMC database (http://ssmc-tl.com/sSMC.html) search. A total of 234 patients with infertility were identified as carriers of sSMC. All chromosomes, except chromosomes 10, 19 and the X, were involved in sSMC, and in 72% the sSMC originated from acrocentric chromosomes. Euchromatic imbalances were caused by the presence of sSMC in 30% of the cases. Putative genes have been identified in only 1.2% of sSMC associated with infertility. The implication of sSMC in infertility could be due to a partial trisomy of some genes but also to mechanical effects perturbing meiosis. Further precise molecular and interphase-architecture studies on sSMC are needed in the future to characterize the relationship between this chromosomal anomaly and human infertility.

  2. [Risk factors associated to female infertility].

    Science.gov (United States)

    Romero Ramos, Ricardo; Romero Gutiérrez, Gustavo; Abortes Monroy, Ignacio; Medina Sánchez, Héctor Gerardo

    2008-12-01

    Incidence of female infertility is growing worldwide and the its rate varies from 10 to 20%. It has been reported diverse risk factors associated with this medical complication. To identify the risk factors with significant association with female infertility. A case-control study was carried out. There were included 440 patients, divided into 220 women with primary or secondary female infertility (cases) and 220 women without infertility recruited at mediate postpartum (controls). Twenty sociodemographic and clinical risk factors for female infertility were analyzed. Statistical analysis was performed with percentages, arithmetic media, standard error, Student t test and chi squared. An alpha value was set at 0.05. There were 6 factors with statistical significance: advanced age (p < 0.001), elevated body mass index (p < 0.001), age of onset of sexual activity (p < 0.001), prior pelvic surgeries (p < 0.001), and presence of stress (p < 0.001). Other risk factors such as smoking, chemical and radiological treatments, pelvic inflammatory disease, exercise, contraceptive use, alcohol intake, drugs, coffee, solvents, glue and insecticides, were not significant. There are clinical and demographic risk factors associated with female infertility. Them identification in women at reproductive age could diminish the frequency of female infertility and, thus, avoid them consequences.

  3. Evaluation of the general health of the infertile couples

    Directory of Open Access Journals (Sweden)

    Mohammad Hossein Baghiani Moghadam

    2011-01-01

    Full Text Available Background: The prevalence of infertility is variable between 5-30% around the world. In Iran, more than 2 million couples suffer from infertility. Infertility causes depression, anxiety, social isolation and sexual dysfunction. Objective: This descriptive study was undertaken to determine general health in infertile couples.Materials and Methods: One hundred and fifty infertile couples attending Yazd Research and Clinical Center for Infertility were randomly selected during March till September 2009. The GHQ-28 questionnaires were completed by researchers, based on face to face interview. It contains 28 items, which have been divided to four sub- items. The results come out by scoring the patients answer from 0 to 84. All data were analyzed by Chi-square and t-test in SPSS software. Results: GHQ scores of all sub-scales and total in women were more than men, which shows general health condition in women is worse than men. There was no relation between the duration of infertility and general health scores. Conclusion: This study suggests that the infertility has significant effect (p=0.001 on health situation of infertile couples, especially infertile women. They are at risk of somatic symptoms (p=0.0001, social dysfunction (p=0.0001 and severe depression (p=0.0001. GHQ could provided help and support in order to improve the health situation of infertile couples.

  4. A prospective study on role of dehydroepiandrosterone (DHEA) on improving the ovarian reserve markers in infertile patients with poor ovarian reserve.

    Science.gov (United States)

    Singh, Neeta; Zangmo, Rinchen; Kumar, Sunesh; Roy, K K; Sharma, J B; Malhotra, Neena; Vanamail, Perumal

    2013-11-01

    The aim of this study was to evaluate the role of dehydroepiandrosterone (DHEA) supplementation on the ovarian reserve markers in infertile patients who were poor responders in previous in vitro fertilization (IVF) cycles. A prospective clinical trial was conducted on 30 patients with history of poor response in previous IVF cycles. These patients were treated with DHEA, (Tab Eema-D, Corona Remedies Pvt Ltd., Ahmedabad, Gujurat, India) 25 mg thrice a day for four months. Ovarian stimulation was done using the previous protocol. Clinical parameters were measured before and treatment with DHEA. Results were analysed using Student's "t" paired test. DHEA resulted in a significant increase (p 38 years). Peak estradiol level on the day of human chorionic gonadotrophin administration also increased significantly (p DHEA has a significant effect in improving the ovarian reserve in poor responders with previously failed IVF cycles. It can help in enhancing clinical pregnancy rate in these patients.

  5. Kisspeptin, unexplained infertility and embryo implantation

    Directory of Open Access Journals (Sweden)

    Aaida Mumtaz

    2017-03-01

    Full Text Available Background Kisspeptin (KP is a neuropeptide that causes the release of the gonadotropin releasing hormone, which controls hypothalamo pituitary ovarian axis and exerts a number of peripheral effects on reproductive organs. The primary objective of this study was to compare baseline KP levels in females with different types of infertility and identify possible correlations with risk of failure to conceive, preclinical abortion and pregnancy after intracytoplasmic sperm injection (ICSI. Materials and Methods A longitudinal cohort study was carried out from August 2014 until May 2015 by recruiting 124 female patients undergoing ICSI, after obtaining ethical approval from the Australian Concept Infertility Medical Center. Cause of infertility due to male, female and unexplained factors was at a frequency of 32 (24%, 33 (31% and 59 (45% among the individuals respectively. KP levels were measured by ELISA assay before the initiation of the ICSI treatment protocol. Outcome of ICSI was categorized into three groups of non-pregnant with beta-human chorionic gonadotropin (β-hCG25 mIU/ml and no cardiac activity, and clinical pregnancy declared upon confirmation of cardiac activity. Results based on cause of infertility and outcome groups were analyzed by one-way ANOVA. Results Females with unexplained infertility had significantly lower levels of KP when compared with those with male factor infertility (176.69 ± 5.03 vs. 397.6 ± 58.2, P=0.001. Clinical pregnancy was observed in 28 (23% females of which 17 (71% had a female cause of infertility. In the non-pregnant group of 66 (53% females, common cause of infertility was unexplained 56(85%. A weak positive correlation of KP levels with fertilized oocytes and endometrial thickness was observed (P=0.04 and 0.01 respectively. Conclusion Deficiency of KP in females with unexplained infertility was associated with reduced chances of implantation after ICSI.

  6. Infertility, infertility treatment, and fetal growth restriction

    DEFF Research Database (Denmark)

    Zhu, Jin Liang; Obel, Carsten; Hammer Bech, Bodil

    2007-01-01

    OBJECTIVE: To examine the association between infertility, with or without treatment, and fetal growth, as well as perinatal and infant mortality. METHODS: From the Danish National Birth Cohort (1997-2003), we identified 51,041 singletons born of fertile couples (time to pregnancy 12 months or less......), 5,787 born of infertile couples conceiving naturally (time to pregnancy more than 12 months), and 4,317 born after treatment. We defined small for gestational age (SGA) as the lowest 5% of birth weight by sex and gestational age. RESULTS: Crude estimates suggested an increased risk of perinatal...... effect on fetal growth. A small-to-moderate increased risk of perinatal mortality in infertile couples cannot be ruled out due to the small number of cases. LEVEL OF EVIDENCE: II. Udgivelsesdato: 2007-Dec...

  7. Correlation between sperm quality and trace elements in infertile patients%不育症患者精液微量元素与精液质量之间的相关性分析

    Institute of Scientific and Technical Information of China (English)

    郑利平; 朱旭; 覃坚; 马南花; 罗开玲

    2012-01-01

    Objective To explore the correlation between semen trace elements and quality in infertile patients. Methods Zinc,I-ron, copper, calcium, magnesium, cadmium in seminal plasma and semen quality were detected for 103 healthy controls (control group) and 500 infertile patients(infertile group). The correlation between seminal level of trace elements and the parameters of semen routine test were analyzed by Spearman correlation analysis. Results Seminal level of zinc in infertile group were significantly lower than control group,but levels of copper and cadmium were higher(P0. 05). Zinc level was positively correlated with sperm motility and density in infertile group(P0.05).不育组精浆钙、镁、铁含量与精液pH值呈负相关(P<0.05),锌含量与精子活率、精子密度呈正相关(P<0.05),镉含量与精子密度、精子活率、活跃精子密度呈负相关(P<0.05).结论 不育症患者精浆中微量元素含量与精液参数存在密切的相关性.

  8. Infertility and Reproductive Function in Patients with Congenital Adrenal Hyperplasia: Pathophysiology, Advances in Management, and Recent Outcomes.

    Science.gov (United States)

    Lekarev, Oksana; Lin-Su, Karen; Vogiatzi, Maria G

    2015-12-01

    Individuals with congenital adrenal hyperplasia have reduced fertility. However, reproductive outcomes have improved over the years. This review provides an update on the multiple pathologic processes that contribute to reduced fertility in both sexes, from alterations of the hypothalamic-pituitary-gonadal axis to the direct effect on gonadal function by elevated circulating adrenal androgens. In addition, elevated serum progesterone concentrations may hinder ovulation and embryo implantation in women, whereas in men testicular adrenal rest tumors can be a major cause of infertility. Suppression of adrenal androgen secretion represents the first line of therapy toward spontaneous conception in both sexes. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. 泰国少精无精不育男性中Y染色体微缺失和染色体异常的发病率%Frequency of Y chromosome microdeletions and chromosomal abnormalities in infertile Thai men with oligozoospermia and azoospermia

    Institute of Scientific and Technical Information of China (English)

    T.Vutyavanich; W.Piromlertamorn; W.Sirirungsi; S.Sirisukkasem

    2007-01-01

    Aim:To investigate the possible causes of oligozoospermia and azoospermia in infertile Thai men, and to find the frequencies of Y chromosome microdeletions and cytogenetic abnormalities in this group. Methods: From June 2003 to November 2005, 50 azoospermic and 80 oligozoospermic men were enrolled in the study. A detailed history was taken for each man, followed by general and genital examinations. Y chromosome microdeletions were detected by multiplex polymerase chain reaction (PCR) using 11 gene-specific primers that covered all three regions of the azoospermic factor (AZFa, AZFb and AZFc). Fifty men with normal semen analysis were also studied. Karyotyping was done with the standard G- and Q-banding. Serum concentrations of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL) and testosterone were measured by electrochemiluminescence immunoassays (ECLIA). Results: Azoospermia and oligozoospermia could be explained by previous orchitis in 22.3%, former bilateral cryptorchidism in 19.2%, abnormal karyotypes in 4.6% and Y chromosome microdeletions in 3.8% of the subjects. The most frequent deletions were in the AZFc region (50%), followed by AZFb (33%) and AZFbc (17%).No significant difference was detected in hormonal profiles of infertile men, with or without microdeletions.Conclusion: The frequencies of Y chromosome microdeletions and cytogenetic abnormalities in oligozoospermic and azoospermic Thai men are comparable with similarly infertile men from other Asian and Western countries.

  10. How patient-centred care relates to patients' quality of life and distress: a study in 427 women experiencing infertility.

    NARCIS (Netherlands)

    Aarts, J.W.M.; Huppelschoten, A.G.; Empel, I.W.H. van; Boivin, J.; Verhaak, C.M.; Kremer, J.A.M.; Nelen, W.L.D.M.

    2012-01-01

    BACKGROUND: The aim of this study was to investigate to what extent patients' experiences with fertility care are associated with their quality of life (QoL), and levels of anxiety and depression. METHODS: We performed a cross-sectional questionnaire study within 29 Dutch fertility clinics, includin

  11. [Genetic aspects of male infertility].

    Science.gov (United States)

    2014-04-01

    We examined 118 men with infertility. Among them we identified phenotypic syndromes associated with infertility in 4 and chromosomal abnormalities in 16. Further molecular genetic study of 98 infertile men found that microdeletions in AZFc-locus had 3, pathological AR allele had 2, CFTR gene mutation had 4 of them. In 37 infertile men an increased DNA fragmentation index (>20%) was found.

  12. Donation of oocytes as treatment for infertility in patients with premature ovarian failure: awarded the "Nicolau de Moraes Barros" prize for gynecology

    Directory of Open Access Journals (Sweden)

    José Gonçalves Franco Júnior

    Full Text Available A total of 7 cycles of embryo transfer by oocyte donation were performed on 5 patients with premature ovary failure (POF. All donors were under 35 of age and the recipients average age was 38.6 years. For synchronization between donor and recipient a semi programmed menstrual cycle was used by means of oral contraceptive followed by ovarian stimulation of donor with clomiphene citrate and human menopausal gonadotrophin. The recipients were easily adjusted to the donors by a flexible model of gradually increasing doses of estradiol valerianate. The average number of oocytes donated was 3.14 and average embryo cleavage rate was 80.2%. The average number of embryos transferred was 2.57. Embryo implantation rate was 22.2%. Clinical gestations occurred in 57.1% of the cycles. This series is probably the first one in Brazilian literature on oocyte donation as treatment for infertility in patients with premature ovarian failure.

  13. Psychiatric Aspects of Infertility

    Directory of Open Access Journals (Sweden)

    Hacer Sezgin

    2014-06-01

    Full Text Available Infertility can be defined as a crisis with cultural, religious, and class related aspects, which coexists with medical, psychiatric, psychological, and social problems. Relation between psychiatric and psychological factors stem from a mutual interaction of both. Family is an important institution in maintaining human existence and raising individuals in line with society's expectations. Fertility and reproduction are seen as universal functions unique to women with raising children as the expected result of the family institution. Incidence of infertility has increased recently and can become a life crisis for a couple. Even though not being able to have a child affects both sexes emotionally, women feel greater amounts of stress, pressure, anxiety, and depression.Consequences of infertility arise from short and long-term devastating effects on both individual's physical and mental health, and marital system. Many studies focus on infertility related psychological and psychiatric disorders (depression, anxiety, grief, marital conflict, gender differences, relation between the causes of infertility and psychopathology, the effects of psychiatric evaluation and intervention -when necessaryon the course of infertility treatment, pregnancy rates, and childbirth. The most important underlying causes of high levels of stress and anxiety that infertile women experience are the loss of maternity, reproduction, sense of self, and genetic continuity. In this review article is to investigate the relationship between medically unexplained symptoms and psychiatric symptoms. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2014; 6(2.000: 165-185

  14. Genetic causes of male infertility.

    Science.gov (United States)

    Stouffs, Katrien; Seneca, Sara; Lissens, Willy

    2014-05-01

    Male infertility, affecting around half of the couples with a problem to get pregnant, is a very heterogeneous condition. Part of patients are having a defect in spermatogenesis of which the underlying causes (including genetic ones) remain largely unknown. The only genetic tests routinely used in the diagnosis of male infertility are the analyses for the presence of Yq microdeletions and/or chromosomal abnormalities. Various other single gene or polygenic defects have been proposed to be involved in male fertility. Yet, their causative effect often remains to be proven. The recent evolution in the development of whole genome-based techniques may help in clarifying the role of genes and other genetic factors involved in spermatogenesis and spermatogenesis defects. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  15. Importance of Seminal Hyaluronidase Activity and Hypo-Osmotic Swelling Test in Male Infertility

    Directory of Open Access Journals (Sweden)

    A.S. Tambe

    2011-07-01

    Full Text Available The conventional seminal parameters like sperm density, motility, morphology, etc. are not perfect indicators of seminal functional quality. Hence, Seminal Hyaluronidase Activity (SHA and Hypo-osmotic Swelling (HOS score of sperms that evaluate healthy sperms of fertilizing potential, were studied in male partners of infertile couples. The semen samples were obtained, by masturbation after 4 days of abstinence, from recently Fertility Proven Males (Group-I, n=30 and Male Partners of Infertile Couples Normozoospermic (Group-II, n=30 and Oligozoospermic (Group-III, n=30]. After performing routine seminal analysis, the semen samples were subjected for SHA and HOS score assessment. The mean  standard deviation values of SHA (mm of ring diameter were 9.901.65, 8.771.87 and 6.501.33 in Group-I, Group-II and Group-III, respectively. Similarly, the mean  standard deviation values of HOS score (% were 65.508.69, 58.7715.95 and 39.009.78 in Group-I, Group-II and Group-III, respectively. The difference in values of SHA and HOS score amongst different Groups was very highly significant statistically (p0.001. Also, we found significant correlation of SHA and HOS score with sperm density, % motility and % normal morphology. This study shows that Normozoospermic Infertile Males, although having normal conventional seminal parameters, have lower SHA and HOS score than Fertility Proven Males. Thus, it emphasizes the importance of SHA and HOS score assessment in infertile males.

  16. Infertility: Inability or Disability?

    Directory of Open Access Journals (Sweden)

    Abha Khetarpal

    2012-06-01

    Full Text Available Disability is a complex phenomenon. It reflects an interaction between features of a person’s body and features of the society in which he or she lives. International Classification of Functioning, Disability and Health (ICF, lays stress on the functional as well as the structural problem of a person. All the definitions of disability also include the disorders of the reproductive and endocrine system. So infertility and impotency should also be included in the category of disability. It affects the participation in areas of life and can have a disabling affect on an individual. Like any other disability the couple has to adapt and integrate infertility in their sense of self thus infertility comes as a major life crisis. Medically, infertility, in most cases, is considered to be the result of a physical impairment or a genetic abnormality. Socially, couples are incapable of their reproductive or parental roles. On social level, infertility in most cultures remains associated with social stigma and taboo just like the social model of disability. Couples who are unable to reproduce may be looked down upon due to social stigmatisation. Infertility can lead to divorces and separation leading to a broken family life. Without labelling infertility as a disability, it is difficult for the people to access services and welfare benefits offered by the government. Infertility treatments are highly sophisticated so they are very expensive and are even not covered by insurance and government aid.In the light of all this it becomes imperative to categorise infertility as disability.

  17. Iatrogenic causes of infertility.

    Science.gov (United States)

    Schoysman, R; Segal, L

    1990-01-01

    The Authors review the list of the iatrogenic causes of infertility. In their opinion the more delicate the structure, the more heavy the price paid to clumsy or erroneous investigation. Such eventual incompetence may lead to further damage of the already existing situation. The Authors however look at the future with relative optimism: incidents become rarer, specialists in gynecology and infertility pay more attention to the delicacy of genital structures and there is an encouraging tendency to refer to infertility specialists those cases who need adequate work-up of their condition.

  18. Do alterations in follicular fluid proteases contribute to human infertility?

    Science.gov (United States)

    Cookingham, Lisa Marii; Van Voorhis, Bradley J; Ascoli, Mario

    2015-05-01

    Cathepsin L and ADAMTS-1 are known to play critical roles in follicular rupture, ovulation, and fertility in mice. Similar studies in humans are limited; however, both are known to increase during the periovulatory period. No studies have examined either protease in the follicular fluid of women with unexplained infertility or infertility related to advanced maternal age (AMA). We sought to determine if alterations in cathepsin L and/or ADAMTS-1 existed in these infertile populations. Patients undergoing in vitro fertilization (IVF) for unexplained infertility or AMA-related infertility were prospectively recruited for the study; patients with tubal or male factor infertility were recruited as controls. Follicular fluid was collected to determine gene expression (via quantitative polymerase chain reaction), enzyme concentrations (via enzyme-linked immunosorbent assays), and enzymatic activities (via fluorogenic enzyme cleavage assay or Western blot analysis) of cathepsin L and ADAMTS-1. The analysis included a total of 42 patients (14 per group). We found no statistically significant difference in gene expression, enzyme concentration, or enzymatic activity of cathepsin L or ADAMTS-1 in unexplained infertility or AMA-related infertility as compared to controls. We also found no statistically significant difference in expression or concentration with advancing age. Cathepsin L and ADAMTS-1 are not altered in women with unexplained infertility or AMA-related infertility undergoing IVF, and they do not decline with advancing age. It is possible that differences exist in natural cycles, contributing to infertility; however, our findings do not support a role for protease alterations as a common cause of infertility.

  19. Diagnostic Testing for Male Factor Infertility

    Science.gov (United States)

    ... Home FAQs Frequently Asked Questions Quick Facts About Infertility FAQs About Infertility FAQs About the Psychological Component of Infertility FAQs About Cloning and Stem Cell Research SART's ...

  20. Endometriosis and Infertility: Can Surgery Help?

    Science.gov (United States)

    ... Home FAQs Frequently Asked Questions Quick Facts About Infertility FAQs About Infertility FAQs About the Psychological Component of Infertility FAQs About Cloning and Stem Cell Research SART's ...

  1. Cryptic infertility and therapeutic options.

    Science.gov (United States)

    Check, J H

    2001-01-01

    Too often infertile patients are given a "herd type" fertility investigation which ultimately leads to expensive, time consuming, and risky in vitro fertilization. However, attention to certain simple details available by non-invasive methods, e.g., checking for premature luteinization, luteinized unruptured follicle syndrome, or performing the post-coital test at the appropriate interval, can lead to a quick solution of the infertility problem. Caution about persistent infertility related to iatrogenic factors, e.g., development of poor post-coital tests or excessively thin endometrium from clomiphene citrate, or development of luteinized unruptured follicle syndrome or premature luteinization by taking follicle maturing drugs, or creating a hostile environment from taking follicle maturing drugs when the woman already made a mature follicle (and would have had a higher success rate with luteal phase support with progesterone) will help achieve pregnancies without necessarily proceeding to the most expensive and invasive procedure of in vitro fertilization. Finally, many wasted cycles of treatment could be avoided by including the simple but very important hypo-osmotic swelling test and measurement of sperm autoantibodies with the first initial semen analysis.

  2. Y-Chromosomal Microdeletion in Idiopathic Azoospermic and Severe Oligozoospermic Indonesian Men

    Directory of Open Access Journals (Sweden)

    Ponco Birowo

    2017-04-01

    Full Text Available Aim: to detect Y-chromosomal microdeletion in Indonesian men with azoospermia or severe oligozoospermia using multiplex PCR. Methods: we performed 2 multiplex PCR amplifications of the Azoospermia Factor (AZF region in 71 men. Criteria for including a patient were fulfilled if they presented with azoospermia or severe oligozoospermia, with or without additional abnormalities of sperm motility or of head morphology, raised or normal levels of FSH, normal levels of LH and testosterone, and with no evidence of testicular tumors or other abnormalities. Five men participated as control persons. Results: partial deletion of AZFa was found in 11 men (15.49%, complete deletion of AZFb in 1 man (1.4%, and complete deletion of AZFc in 1 man (1.4%. The unspecific type of deletion was also detected, including the DBY gene in 2 men (2.81%, and partial deletion of both AZFa and AZFb in 2 men (2.81%. No AZF deletion was observed in the control probands. Related to the type of deletion, the AZFa and AZFb deletion showed spermatogenesis arrest in most tubules, while deletion of the DBY gene is associated with the sertoli cell only (SCO syndrome. Conclusion: the frequency of partial deletion of AZFa was found to be relatively high in our center. The type of deletion is associated with the testicular histology.

  3. OVARIAN AGING AND INFERTILITY TREATMENT

    Directory of Open Access Journals (Sweden)

    Helena Meden Vrtovec

    2003-12-01

    Full Text Available Background. Due to changes in the socio-economic environment the first pregnancy is being more often postponed to advanced age; an increasing number of women seek medical help for infertility in their late thirties. Degenerative processes in the ovary start as early as after 35 years of age. When the woman is over 38, the signs of hormonal changes occur (FSH, inhibin, the menstrual cycle changes, and fertility is being increasingly reduced. Infertility treatment by assisted reproduction technology (ART has proved less efficient in older than in younger women.Material and methods. In a retrospective analysis we evaluated the success rates achieved with homologous intrauterine insemination (IUI, in vitro fertilization and embryo-transfer (IVF-ET, intracytoplasmic sperm injection (ICSI, and compared them in regard to the women > 38 years vs. < 38 years.Results. After IUI the pregnancy rate in the women over 38 was 3.7% per patient (1.5% per cycle and 28.0% (9.9% in the women younger than 38 years. After IVF-ET the pregnancy rate in the over 38-year group was 16% per patient (14% per cycle, and 28% per patient (25% per cycle in the less than 38-year group. After ICSI, the pregnancy rate in the group over 38 years was 11% per patient (9% per cycle, and 25% per patient (22% per cycle in the less than 38-year group. In the analysed population, the spontaneous abortion rate was 26.0% in the group of women aged over 38 years, and 14.0% in the group of women aged less than 38 years.Conclusions. Before introduction of an ART procedure the woman with advanced age should be properly counselled and well informed about poor success of their infertility treatment and high spontaneous abortion rate.

  4. Male infertility workup needs additional testing of expressed prostatic secretion and/or post-massage urine.

    Directory of Open Access Journals (Sweden)

    Margus Punab

    Full Text Available The male factor accounts for almost 50% of infertility cases. Inflammation may reduce semen quality via several pathways, including oxidative stress (OxS. As male infertility routinely is assessed using semen analysis only, the possible presence of non-leukocytospermic asymptomatic inflammatory prostatitis may be overlooked. We compared local and systemic OxS levels in male partners of infertile couples with different inflammation patterns in their genital tract and/or oligospermia. Subjects (n=143 were grouped according to inflammation in their semen, expressed prostatic secretion (EPS, and/or post-massage urine (post-M. Systemic (8-isoprostanes in urine and local (diene conjugates and total antioxidant capacity in seminal plasma OxS was measured The levels of OxS markers were significantly elevated in both severe inflammation groups--leukocytospermic men and subjects whose inflammation was limited only to EPS and/or post-M. Comparison between oligospermic and non-oligospermic men with genital tract inflammation, and oligozoospermic men with or without inflammation in the genital tract indicated that inflammation but not oligospermia status had significant impact on the measured OxS markers. Hence, a high leukocyte count in prostate-specific materials (EPS, post-M, even in absence of clear leukocytopsermia, is an important source of local and systemic OxS that may be associated with male infertility and affect general health. We suggest including the tests for detection of inflammation of the prostate into the workup of infertile men as was suggested in the WHO 1993 recommendation.

  5. Coital frequency and infertility: which male factors predict less frequent coitus among infertile couples?

    Science.gov (United States)

    Perlis, Nathan; Lo, Kirk C; Grober, Ethan D; Spencer, Leia; Jarvi, Keith

    2013-08-01

    To determine the coital frequency among infertile couples and which factors are associated with less frequent coitus. Cross-sectional study. Tertiary-level male infertility clinic. A total of 1,298 infertile men. Administration of computer-based survey, semen analysis, and serum hormone evaluation. Monthly coital frequency. A total of 1,298 patients presented to clinic for infertility consultation and completed the computer-based survey. The median male age was 35 years (interquartile range [IQR] 32-39 years) and the median duration of infertility was 2 years (IQR 1-4 years) before consultation. Median monthly coital frequency was seven (IQR 5-10; range 0-40); 24% of couples were having intercourse ≤ 4 times per month. Overall, 0.6%, 2.7%, 4.8%, 5.8%, and 10.8% of the men reported having intercourse 0, 1, 2, 3, and 4 times per month, respectively. When simultaneously taking into account the influence of age, libido, erectile function, and semen volume on coital frequency, older patients had 1.05 times higher odds (per year of age) of less frequent coitus (odds ratio 1.05, 95% confidence interval 1.03-1.08). In addition, patients with better erectile function had 1.12 times higher odds (per point on Sexual Health Inventory for Men scale) of more frequent coitus (odds ratio 1.12, 95% confidence interval 1.09-1.18). Similar to the general population, most infertile couples report having coitus more than four times per month. Older male age and erectile dysfunction are independent risk factors for less frequent coitus among infertile men, which could have an impact on fertility. Coital frequency should be considered in infertility assessments. Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  6. Oxidative stress induces idiopathic infertility in Egyptian males

    African Journals Online (AJOL)

    Yomi

    2012-01-19

    Jan 19, 2012 ... Oxidative stress (OS) would play a vital role in etiology of ... To examine OS effect on Egyptian men fertility, sperm samples were obtained from infertile .... 1 ml semen. According to seminal quality profile, the infertile patients were .... donors and idiopathic men in terms of semen volume (ml) and leukocytes ...

  7. 多囊卵巢综合征不孕症患者状态--特质焦虑调查分析%Investigation and Analysis of State:Trait Anxiety in Polycystic Ovary Syndrome Patients with Infertility

    Institute of Scientific and Technical Information of China (English)

    华宙佳; 丁彩飞

    2013-01-01

      [目的]调查多囊卵巢综合征(polycystic ovary syndrome, PCOS)不孕患者状态-特质焦虑情况。[方法]采用状态-特质焦虑问卷调查分析172例PCOS不孕患者和77例非PCOS不孕症患者的心理健康状况。[结果]⑴两组调查人群的人口统计学资料基本类同,PCOS不孕组状态焦虑评分(43.29+10.06)分明显高于非PCOS不孕组(38.00±8.32)分,两组焦虑评分比较差异有统计学意义(P<0.05);⑵PCOS不孕组特质焦虑评分(43.49±8.98)分明显高于非PCOS不孕组(37.86±12.79)分,两组差异有统计学意义(P<0.05);⑶PCOS不孕组状态焦虑总分受不孕时间的影响最大,两者呈正相关(t=3.292,P<0.05);与年龄呈负相关(t=2.760,P<0.05)。[结论]PCOS不孕症患者具有较高水平状态焦虑和特质焦虑,其状态焦虑程度与不孕时间和年龄具有相关性。%Objective] Survey state-trait anxiety situation in polycystic ovary syndrome(PCOS) patients with infertility. [Methods]The State-Trait Anxiety Inventory(STAI) was used to assess psychological health in 172 PCOS patients with infertility and 77 infertile women without PCOS. [Results] ①The de-mographic variables of the three groups were similar to each other, score of state anxiety of the PCOS infertility group(43.29+10.06) was higher than the group of infertile without PCOS(38.00+8.32), the level of the two groups had significant differences. ②The trait anxiety score of the PCOS infertility group( 43.49+8.98) was higher than the group of infertile without PCOS(37.86+12.79) ,it had statistical y significant difference. ③The time of infertility had the biggest influence on the state anxiety of PCOS infertility group, both were positively correlated(t=3.292);and the total score of state anxiety had a negative correlation with age(t=2.760).[Conclusion]PCOS infertility patients have a higher level state anxiety and trait anxiety, its state anxiety level

  8. Epidemiology of infertility: social problems of the infertile couples

    African Journals Online (AJOL)

    Epidemiology of infertility: social problems of the infertile couples. Margaret .... imbalance in the power relations between men and women to such an .... India in 1993, the African Academy of Sciences issued a dissent- ..... York: Plenum Press.

  9. REPRODUCTIVE FUNCTION INDICATORS COUPLES BRYANSK REGION, INFERTILITY

    Directory of Open Access Journals (Sweden)

    Dekhnich Svetlana Nikolaevna

    2013-03-01

    Full Text Available The purpose of research - the study of the dynamics and trends of the major reproductive health Bryansk region. Novelty: established medical-social aspects of reproductive health at the regional level. The methodology of the work. Direct observation of the state of the reproductive health, clinical tools, functional methods, statistical methods, data from vykopirovka "outpatient medical card" applied to autonomous public institutions Bryansk Regional Health Center for Family Planning and Reproduction (Gause BOTSPSR from 2008 to 2012. Results. Revealed a high incidence of infertility, high frequency tube-peritoneal and endocrine factors of the disease. Among patients with infertility, most suffered various gynecological surgeries, which significantly reduced ovarian reserve and the quality of oocytes during IVF. Field of application of the results. The data obtained can be used in reproductive medicine clinics, which will allow a more considered approach to the appointment of surgical interventions in patients with infertility, greater use of assisted reproduction techniques.

  10. Epigenetics of reproductive infertility.

    Science.gov (United States)

    Das, Laxmidhar; Parbin, Sabnam; Pradhan, Nibedita; Kausar, Chahat; Patra, Samir K

    2017-06-01

    Infertility is a complex pathophysiological condition. It may caused by specific or multiple physical and physiological factors, including abnormalities in homeostasis, hormonal imbalances and genetic alterations. In recent times various studies implicated that, aberrant epigenetic mechanisms are associated with reproductive infertility. There might be transgenerational effects associated with epigenetic modifications of gametes and studies suggest the importance of alterations in epigenetic modification at early and late stages of gametogenesis. To determine the causes of infertility it is necessary to understand the altered epigenetic modifications of associated gene and mechanisms involved therein. This review is devoted to elucidate the recent mechanistic advances in regulation of genes by epigenetic modification and emphasizes their possible role related to reproductive infertility. It includes environmental, nutritional, hormonal and physiological factors and influence of internal structural architecture of chromatin nucleosomes affecting DNA and histone modifications in both male and female gametes, early embryogenesis and offspring. Finally, we would like to emphasize that research on human infertility by gene knock out of epigenetic modifiers genes must be relied upon animal models.

  11. Infertility and uterine fibroids.

    Science.gov (United States)

    Zepiridis, Leonidas I; Grimbizis, Grigoris F; Tarlatzis, Basil C

    2016-07-01

    Uterine fibroids are the most common tumors in women and their prevalence is higher in patients with infertility. At present, they are classified according to their anatomical location, as no classification system includes additional parameters such as their size or number. There is a general agreement that submucosal fibroids negatively affect fertility, when compared to women without fibroids. Intramural fibroids above a certain size (>4 cm), even without cavity distortion, may also negatively influence fertility. However, the presence of subserosal myomas has little or no effect on fertility. Many possible theories have been proposed to explain how fibroids impair fertility: mechanisms involving alteration of local anatomical location, others involving functional changes of the myometrium and endometrium, and finally endocrine and paracrine molecular mechanisms. Nevertheless, any of the above mentioned mechanisms can cause reduced reproductive potential, thereby leading to impaired gamete transport, reduced ability for embryo implantation, and creation of a hostile environment. The published experience defines the best practice strategy, as not many large, well-designed, and properly powered studies are available. Myomectomy appears to have an effect in fertility improvement in certain cases. Excision of submucosal myomas seems to restore fertility with pregnancy rates after surgery similar to normal controls. Removal of intramural myomas affecting pregnancy outcome seems to be associated with higher pregnancy rates when compared to non-operated controls, although evidence is still nοt sufficient. Treatment of subserosal myomas of reasonable size is not necessary for fertility reasons. The results of endoscopic and open myomectomy are similar; thus, endoscopic treatment is the recommended approach due to its advantages in patient's postoperative course.

  12. Infertility Research at the NICHD

    Science.gov (United States)

    ... Resources Interviews & Selected Staff Profiles Multimedia Focus on Infertility Research at the NICHD Skip sharing on social ... Unravel the Complex Causes of and Treatments for Infertility According to the Centers for Disease Control and ...

  13. Endometriosis: Does It Cause Infertility?

    Science.gov (United States)

    ... Society for Reproductive Medicine Endometriosis: Does It Cause Infertility? This fact sheet was developed in collaboration with ... a surgical procedure called laparoscopy. Does endometriosis cause infertility? If you have endometriosis, it may be more ...

  14. Influência do período de abstinência sexual sobre as características seminais de homens inférteis Influence of abstinence period on seminal characteristics in infertile men

    Directory of Open Access Journals (Sweden)

    Fábio Firmbach Pasqualotto

    2006-01-01

    December 2004. We excluded men with a normal semen analysis or women with abnormalities suggestive of infertility. Each man produced two semen samples in a short period of time (30 min to 1 h. We evaluated semen volume, total motile sperm count and percentage sperm motility. Comparisons were made between the first and second semen samples. After pooling the samples, we compared the total motile sperm count between the first sample and the pooled samples. Statistical evaluation was performed by Student's t test and the chi2 test. RESULTS: in oligozoospermic men, there were no differences in the semen characteristics between the first and the second seminal samples (p>0.05. The total motile sperm count increased significantly in the second sample in comparison to the first sample in asthenozoospermic (42.4±6.8 vs 51.5±7.2x10(6 sperm/mL and oligoasthenozoospermic men (11.1±7.4 vs 14.35±7.2x10(6 sperm/mL (p<0.05. The pool of two ejaculates increased the total motile sperm count in comparison to the first sample (p<0.05 in oligozoospermic, asthenozoospermic and oligoasthenozoospermic men by 110.5, 110.3 and 136.03%, respectively. CONCLUSIONS: a short period of abstinence is associated with higher sperm motility in infertile men. The pool of two semen samples is a way to increase the total motile sperm count in this group of patients whose wives want to undergo an intrauterine insemination instead of in vitro fertilization.

  15. Oxidative stress & male infertility.

    Science.gov (United States)

    Makker, Kartikeya; Agarwal, Ashok; Sharma, Rakesh

    2009-04-01

    The male factor is considered a major contributory factor to infertility. Apart from the conventional causes for male infertility such as varicocoele, cryptorchidism, infections, obstructive lesions, cystic fibrosis, trauma, and tumours, a new and important cause has been identified: oxidative stress. Oxidative stress is a result of the imbalance between reactive oxygen species (ROS) and antioxidants in the body. It is a powerful mechanism that can lead to sperm damage, deformity and eventually, male infertility. This review discusses the physiological need for ROS and their role in normal sperm function. It also highlights the mechanism of production and the pathophysiology of ROS in relation to the male reproductive system and enumerate the benefits of incorporating antioxidants in clinical and experimental settings.

  16. Treatment of Chinese Herbal Medicine for Female Infertility.

    Science.gov (United States)

    Jiang, Dan; Li, Lily; Zeng, Bai-Yun

    2017-01-01

    Female infertility is when a woman of reproductive age and sexual active, without contraception, cannot get pregnant after a year and more or keeps having miscarriages. Although conventional treatments for infertility such as hormone therapy, in vitro fertilization and many more, helped many female patients with infertility get pregnant during past a few decades, it is far from satisfactory with prolonging treatment time frames and emotional and financial burden. In recent years, more patients with infertile problems are seeking to alternative and complementary medicines to achieve a better outcome. In particular, Chinese herbal medicine (CHM) is increasingly popular for treating infertility due to its effectiveness and complimentary with conventional treatments. However, the mechanisms of action of CHM in treating female infertility are not well understood. In this chapter authors reviewed research development of CHM applied in many infertile models and CHM clinical studies in many conditions associated with female infertility, published in past 15 years. The data of review showed that CHM has either specific target mechanisms of action or multitarget mechanisms of action, via regulating relevant hormone levels in female reproductive system, improving ovary function, enhancing uterine receptivity. More studies are warranted to explore the new drugs from CHM and ensure safety, efficacy, and consistency of CHM. © 2017 Elsevier Inc. All rights reserved.

  17. Procreative sex in infertile couples: the decay of pleasure?

    Directory of Open Access Journals (Sweden)

    Marci Roberto

    2012-11-01

    Full Text Available Abstract Background Infertility represents a major challenge to the emotional balance and sexual life of couples, with long-lasting and gender-specific effects. The objective of this study is to explore personality features of infertile patients and detect possible sexual disorders in couples undergoing infertility treatment. Materials and methods In this prospective study 60 infertile couples and 52 fertile control couples were asked to complete standardized and validated questionnaires: the Adjective Check List (ACL to enquire about personality features and the Female Sexual Function Index (FSFI or the International Index of Erectile Function (IIEF to assess sexual functioning of female and male partners. The study population was divided into 3 groups: Group A (N = 30, recently diagnosed infertile couples Group B (N = 30, infertile couples already undergoing Intrauterine Insemination and Group C (N = 52, fertile control group. Results Infertile patients did not display any distinguishing personality features. Regarding sexual function, men of all the three groups scored higher in both questionnaires (sexual satisfaction, desire and orgasm than their female partners. Comparing results between groups, Group A male partners obtained lower scores in all the subscales. Women belonging to Group A and Group B showed an impairment of sexual arousal, satisfaction, lubrification and orgasm when compared to fertile controls. Conclusions Even if at the very first stages of infertility treatment no personality disturbances can be detected, the couples’ sexual life is already impaired with different sexual disorders according to gender.

  18. Is There a Relationship between Ovarian Epithelial Dysplasia and Infertility?

    Directory of Open Access Journals (Sweden)

    Gautier Chene

    2012-01-01

    Full Text Available Aim. Ovarian epithelial dysplasia was initially described in material from prophylactic oophorectomies performed in patients at genetic risk of ovarian cancer. Similar histopathological abnormalities have been revealed after ovulation stimulation. Since infertility is also a risk factor for ovarian neoplasia, the aim of this study was to study the relationship between infertility and ovarian dysplasia. Methods. We blindly reviewed 127 histopathological slides of adnexectomies or ovarian cystectomies according to three groups—an exposed group to ovulation induction (n = 30, an infertile group without stimulation (n = 35, and a spontaneously fertile control group (n = 62—in order to design an eleven histopathological criteria scoring system. Results. The ovarian dysplasia score was significantly higher in exposed group whereas dysplasia score was low in infertile and control groups (resp., 8.21 in exposed group, 3.69 for infertile patients, and 3.62 for the controls. In the subgroup with refractory infertility there was a trend towards a more severe dysplasia score (8.53 in ovulation induction group and 5.1 in infertile group. Conclusion. These results raise questions as to the responsibility of drugs used to induce ovulation and/or infertility itself in the genesis of ovarian epithelial dysplasia.

  19. Infertility: Medical and Social Choices.

    Science.gov (United States)

    Congress of the U.S., Washington, DC. Office of Technology Assessment.

    This report illustrates a range of options for Congressional action in nine principal areas of public policy related to infertility: (1) collecting data on reproductive health; (2) preventing infertility; (3) information to inform and protect consumers; (4) providing access to infertility services; (5) reproductive health of veterans; (6) transfer…

  20. Forgotten intrauterine device contributing to infertility.

    Science.gov (United States)

    Igberase, Gabriel O

    2011-07-01

    The aim of the study is to show that long standing forgotten intrauterine device contributes to infertility, reporting three cases presented at Central Hospital Warri, Nigeria, a government tertiary health center. Three cases of forgotten intrauterine contraceptive device (IUCD) contributing to infertility were seen. Two were inserted for contraceptive reasons while one was inserted while being managed for uterine synechae. Health care providers should ensure proper documentation of all procedures carried out, adequate counseling which should include taking an informed consent and also ensuring both short and long term follow up of their clients. Also all patients being evaluated for infertility and clients with past history of intrauterine device must have a speculum examination and ultrasound scan carried out.

  1. Forgotten intrauterine device contributing to infertility

    Directory of Open Access Journals (Sweden)

    Gabriel O. Igberase

    2011-10-01

    Full Text Available The aim of the study is to show that long standing forgotten intrauterine device contributes to infertility, reporting three cases presented at Central Hospital Warri, Nigeria, a government tertiary health center. Three cases of forgotten intrauterine contraceptive device (IUCD contributing to infertility were seen. Two were inserted for contraceptive reasons while one was inserted while being managed for uterine synechae. Health care providers should ensure proper documentation of all procedures carried out, adequate counseling which should include taking an informed consent and also ensuring both short and long term follow up of their clients. Also all patients being evaluated for infertility and clients with past history of intrauterine device must have a speculum examination and ultrasound scan carried out.

  2. Infertility, infertility treatment and behavioural problems in the offspring

    DEFF Research Database (Denmark)

    Zhu, Jin Liang; Obel, Carsten; Basso, Olga

    2011-01-01

    Behavioural patterns in children of infertile couples may be influenced by both the underlying causes of infertility and stress in the couples. Treatment procedures, such as culture media and manipulation of gametes and embryos, may also result in developmental problems. We examined behavioural...... problems in children as a function of infertility and infertility treatment, using data from three population-based birth cohorts in Denmark (Aalborg-Odense Birth Cohort, Aarhus Birth Cohort and Danish National Birth Cohort). Information on time to pregnancy and infertility treatment was collected during...... to pregnancy of >12 months and no infertility treatment had a behavioural pattern similar to children of fertile parents. Teachers reported a higher total difficulties score for children born after infertility treatment, but no significant differences were seen on any subscales of the teachers' report...

  3. Psychosocial Problems during Infertility Treatment

    Directory of Open Access Journals (Sweden)

    Nurcan Kirca

    2013-06-01

    Full Text Available Infertility is a complex situation crisis which is often psychologically-threatening and emotionally stressful for both partners as well as economically expensive and causes physical pain due to the operations performed for diagnosis and treatment purposes. Infertility has physical, psychological, social, emotional and financial impacts. Infertile couples are under a great social pressure, and need to conceal the problem as it is exceptionally private for them. Infertile individuals are destitute of support when they do not share their pregnancy problems with their families and relatives. Couples define their infertility experience as the most stressful experience of their lives.

  4. The efficacy of varicocelectomy for 132 infertile patients with varicocele%132例不育男性精索静脉曲张患者手术疗效分析

    Institute of Scientific and Technical Information of China (English)

    唐运革; 唐立新; 王奇玲; 刘晃; 汤乐; 钟安

    2011-01-01

    目的 分析不育男性精索静脉曲张(VC)患者手术后的疗效.方法 132例不育男性VC患者接受小切口腹膜后精索静脉高位结扎手术(改良Palomo术)前后精液按WHO标准常规检测分析,并在术后24个月随访配偶妊娠情况.结果 132例患者术后精子密度、前向运动精子百分率、正常形态精子百分率和总精子数均较术前明显升高(P<0.001),术后配偶的受孕率为53.0%(70/132).多因素分析结果提示仅不育时间对患者配偶妊娠结局有影响,不育时间每增加1个月,妊娠机会降低为0.937(95%CI:0.907~0.968)倍.不育时间36个月及以上组配偶妊娠率为37.5%,显著低于12~23个月组的73.7%和24~35个月组的70.7%(P=0.002).结论 手术治疗精索静脉曲张可以改善不育男性精液参数,提高妊娠率.不育时间超过3年,术后获得妊娠的概率降低.%Objective To evaluate the efficacy of varicocelectomy for infertile patients with varicocele. Methods Total of 132 patients with varicocele were enrolled in the study. The qualities of semen of these patients before and after varicocelectomy were assessed. Semen analysis was performed based on the methods described in the WHO manual. Their spouses were followed up for 24 months on pregnancy. Results After varicoceletomy, a significant increase was found in sperm density, percentage of progressive motility, percentage of sperm with normal mophology and total sperm number (P<0.001). The pregnancy rate of their spouses were 53.0%(70/132). The pregnancy probability of the patients' spouses was affected by their infertile months. The pregnancy probability dcreased 0.937(95% CI:0.907-0.968) fold in parallel with the infertile time prolonging 1 month. The pregnancy rate was 37.5% for patients with infertile months over 36 months. It was significantly lower than that of patients with 12 to 23 infertile months (73.7%) or the patients with 24 to 35 infertile months(70.7%)(P<0.01). Conclusion

  5. Lycopene and male infertility

    Institute of Scientific and Technical Information of China (English)

    Damayanthi Durairajanayagam; Ashok Agarwal; Chloe Ong; Pallavi Prashast

    2014-01-01

    Excessive amounts of reactive oxygen species (ROS) cause a state of oxidative stress, which result in sperm membrane lipid peroxidation, DNA damage and apoptosis, leading to decreased sperm viability and motility. Elevated levels of ROS are a major cause of idiopathic male factor infertility, which is an increasingly common problem today. Lycopene, the most potent singlet oxygen quencher of all carotenoids, is a possible treatment option for male infertility because of its antioxidant properties. By reacting with and neutralizing free radicals, lycopene could reduce the incidence of oxidative stress and thus, lessen the damage that would otherwise be inlficted on spermatozoa. It is postulated that lycopene may have other beneifcial effects via nonoxidative mechanisms in the testis, such as gap junction communication, modulation of gene expression, regulation of the cell cycle and immunoenhancement. Various lycopene supplementation studies conducted on both humans and animals have shown promising results in alleviating male infertility-lipid peroxidation and DNA damage were decreased, while sperm count and viability, and general immunity were increased. Improvement of these parameters indicates a reduction in oxidative stress, and thus the spermatozoa is less vulnerable to oxidative damage, which increases the chances of a normal sperm fertilizing the egg. Human trials have reported improvement in sperm parameters and pregnancy rates with supplementation of 4-8 mg of lycopene daily for 3-12 months. However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene as a treatment for male infertility.

  6. Parenting after Infertility

    Science.gov (United States)

    Olshansky, Ellen

    2009-01-01

    Becoming a parent after experiencing infertility can pose unique challenges to early parenthood. Parents may struggle with the normal anxiety and fatigue, as well as possible depression, that accompany new parenthood, but with added guilt or shame because of how much they wanted a child and how hard they worked to become parents. These feelings…

  7. Fertility and Infertility.

    Science.gov (United States)

    Orgebin-Crist, Marie-Claire; And Others

    In this report, emphasis is placed on major research developments in the reproductive sciences, their impact on the health of individuals as well as on that of society, and on current trends that may provide new opportunities for future research in fertility and infertility. In the first section, major developments in the reproductive sciences are…

  8. Fertility and Infertility.

    Science.gov (United States)

    Orgebin-Crist, Marie-Claire; And Others

    In this report, emphasis is placed on major research developments in the reproductive sciences, their impact on the health of individuals as well as on that of society, and on current trends that may provide new opportunities for future research in fertility and infertility. In the first section, major developments in the reproductive sciences are…

  9. Parenting after Infertility

    Science.gov (United States)

    Olshansky, Ellen

    2009-01-01

    Becoming a parent after experiencing infertility can pose unique challenges to early parenthood. Parents may struggle with the normal anxiety and fatigue, as well as possible depression, that accompany new parenthood, but with added guilt or shame because of how much they wanted a child and how hard they worked to become parents. These feelings…

  10. Lycopene and male infertility

    Directory of Open Access Journals (Sweden)

    Damayanthi Durairajanayagam

    2014-06-01

    Full Text Available Excessive amounts of reactive oxygen species (ROS cause a state of oxidative stress, which result in sperm membrane lipid peroxidation, DNA damage and apoptosis, leading to decreased sperm viability and motility. Elevated levels of ROS are a major cause of idiopathic male factor infertility, which is an increasingly common problem today. Lycopene, the most potent singlet oxygen quencher of all carotenoids, is a possible treatment option for male infertility because of its antioxidant properties. By reacting with and neutralizing free radicals, lycopene could reduce the incidence of oxidative stress and thus, lessen the damage that would otherwise be inflicted on spermatozoa. It is postulated that lycopene may have other beneficial effects via nonoxidative mechanisms in the testis, such as gap junction communication, modulation of gene expression, regulation of the cell cycle and immunoenhancement. Various lycopene supplementation studies conducted on both humans and animals have shown promising results in alleviating male infertility-lipid peroxidation and DNA damage were decreased, while sperm count and viability, and general immunity were increased. Improvement of these parameters indicates a reduction in oxidative stress, and thus the spermatozoa is less vulnerable to oxidative damage, which increases the chances of a normal sperm fertilizing the egg. Human trials have reported improvement in sperm parameters and pregnancy rates with supplementation of 4-8 mg of lycopene daily for 3-12 months. However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene as a treatment for male infertility.

  11. Psychological determinants of life satisfaction in women undergoing infertility treatment

    Directory of Open Access Journals (Sweden)

    Aleksandra Anna Dembińska

    2016-01-01

    Full Text Available Background Infertility treatment is a long-term process, spread out over months, or even years, and carries no guarantee of success. It generates an incessant state of uncertainty which becomes a chronic state of psychological discomfort. Each stage of treatment may become a source of more trouble. Women deciding to undergo infertility treatment are exposed to many negative feelings concerning different aspects of their life. Participants and procedure The present study was an attempt to understand psychological determinants of life satisfaction in women undergoing infertility treatment. The study group included 470 women treated for infertility. Results Patients perceiving more social support in general, as well as more of the support types used in the study, i.e. emotional, instrumental, informational and institutional support, and support from family and friends, have better self-esteem, higher acceptance of their infertility, higher satisfaction with life, higher hope as an emotional state, and lower levels of anxiety and depression. Three negative emotional states, i.e. anxiety, depression and irritation, are predictors influencing (lowering life satisfaction of women struggling with infertility. The strongest of these predictors is depression, which is also a factor lowering the acceptance of one’s own infertility. The conducted analyses revealed that predictors influencing the life satisfaction of patients treated for infertility are self-esteem and acceptance of one’s own infertility (apart from the aforementioned emotional state – anxiety, depression, irritation. It was found that the higher the self-esteem and acceptance of one’s own infertility, the higher was the satisfaction with life. Conclusions Knowledge of these determinants is extremely valuable for medical personnel conducting treatments, because, according to many studies, the psychological state of women suffering from procreation problems is connected not only with

  12. 循证医学在治疗多囊卵巢综合征中的应用%Evidence-based Clinical Treatment for a Infertile Patient Diagnosed with Polycystic Ovary Syndrome

    Institute of Scientific and Technical Information of China (English)

    蔡召忠; 徐华; 连玉红; 魏娟; 瞿萍; 邓守恒

    2011-01-01

    采用循证治疗的方法为1例已婚未育PCOS患者制定合理的治疗方案,有效提高了治疗疗效和妊娠率.%We take an individualized evidence-based treatment for infertile patients diagnosed with polycystic ovary syndrome. The results showed that treatment efficacy and pregnancy rate had been significantly improved.

  13. Infertility: Ongoing Global challenge of new millennium

    Directory of Open Access Journals (Sweden)

    Kantibhai Naranbhai Sonaliya

    2016-06-01

    Full Text Available Background: Infertility tends to be the global challenge even in the second decade of the new millennium. Especially in developing countries like India, it is still one the most lethal social evil responsible for a big proportion of cases of psychological disturbances including suicide. Again, recently, few conditions other than communicable or Non-communicable diseases are given place among the categories of significant public health problems like Road Traffic Accidents, Burns, Poisoning, drowning and few more. But, for developing countries like India, the list is incomplete without inclusion of Infertility (there may be several others also. In public health, tuberculosis, leprosy and some other diseases are considered social diseases which produce social stigma for the patients and/or his family members.1 In same manner, Infertility is an important cause of social stigmatization since centuries for a couple suffering from, especially for woman involved. During a transitory phase of industrialization and socio-economic development, the situation is changed a minute smidgen at urban areas of India but at rural parts, sub-urban or even at urban slums (mainly among pockets of recent migrants the situation is as same as a few hundred years ago. A female of no religion, caste, social status or higher level of education are barred from some stringent mores related to infertility. Infertile females are still not allowed to take part in so many religious or social ceremonies; on the contrary, they have to face more harassment including domestic violence than their counterparts, who have given birth to the child. Due to social, psychological, economic disturbances, they are forced to take multiple sorts of treatments including religious quacks. So many infertile women are exploited physically and economically also in such weird ways of treatment to gain a pregnancy.

  14. Hysterosalpingographic findings in infertile women: A seven year ...

    African Journals Online (AJOL)

    2011-03-23

    Mar 23, 2011 ... cost effectiveness still makes it the standard procedure for evaluating female infertility ... patient and personnel, higher cost than ultrasound, and sometimes scarcity of ..... Source of Support: Nil, Conflict of Interest: None declared.

  15. Laparohysteroscopy in female infertility: A diagnostic cum therapeutic tool in Indian setting.

    Science.gov (United States)

    Puri, Suman; Jain, Dinesh; Puri, Sandeep; Kaushal, Sandeep; Deol, Satjeet Kaur

    2015-01-01

    To evaluate the role of laparohysteroscopy in female infertility andto study the effect of therapeutic procedures in achieving fertility. Patients with female infertility presenting to outpatient Department of Obstetrics and Gynecology were evaluated over a period of 18 months. Fifty consenting subjects excluding male factor infertility with normal hormonal profile and no contraindication to laparoscopy were subject to diagnostic laparoscopy and hysteroscopy. T-test. We studied 50 patients comprising of 24 (48%) cases of primary infertility and 26 (52%) patients of secondary infertility. The average age of active married life for 50 patients was between 8 and 9 years. In our study, the most commonly found pathologies were PCOD, endometroisis and tubal blockage. 11 (28.2) patients conceived after laparohysteroscopy followed by artificial reproductive techniques. This study demonstrates the benefit of laparohysteroscopy for diagnosis and as a therapeutic tool in patients with primary and secondary infertility. We were able to achieve a higher conception rate of 28.2%.

  16. 不孕患者子宫内膜病变的临床病理分析%Clinical and pathological analysis of infertile patients with endometrial lesions

    Institute of Scientific and Technical Information of China (English)

    叶松; 曹凤妹; 詹永春; 汤琪乐

    2014-01-01

    目的:探讨不孕患者子宫内膜病变的病理类型以及对治疗效果的影响。方法:选取不孕患者104例,于月经来潮后12h内行诊断性刮宫并进行病理分析。分泌反应类患者给予活血补肾为主的中医治疗,增生反应类患者给予克罗米芬口服。结果:子宫内膜病变中以分泌类反应较多,其中尤其以分泌欠佳所占比例最大,而增生类反应中以增生反应较多见。不同程度分泌异常患者随着病变严重程度增加,治疗效果也越来越差,组间比较差异明显,具有统计学意义(P<0.05)。不同类型增生异常患者治疗效果差别不大,无统计学意义(P>0.05)。结论:分泌类反应患者的病理诊断有助于对患者预后作出判断;增生类反应者虽然不同类型预后差别不大,但是治疗手段却不同,因此病理诊断也十分必要。%Objectives:To investigate the pathological type of infertility patients with endometrial lesions and their impact on the treatment effect.Methods:1 04 infertile patients were selected and applied diagnostic curet-tage within 1 2h since the beginning of menstrual period for pathological analysis.Patients in the secretory reaction class received Chinese medicine treatment highlighting Huoxue tonifying the kidney;patients in the proliferative re-sponse class were given oral clomiphene citrate.Results:Of the endometrial lesions,secretion response took the majority,especially poor secretion;while for the proliferation class,proliferative reaction was the majority.With the increasing severity degrees of diacrisis,treatment effect was getting worse and worse,with statistically significant differences between groups (P0.05).Conclusion:The pathological diagnosis of patients in the secretory response class is helpful to judge the prognosis;while for patients with proliferative response;al-though prognostic difference is not significant,treatment methods are different,so it is

  17. Overtreatment in couples with unexplained infertility.

    Science.gov (United States)

    Kersten, F A M; Hermens, R P G M; Braat, D D M; Hoek, A; Mol, B W J; Goddijn, M; Nelen, W L D M

    2015-01-01

    What is the percentage of overtreatment, i.e. fertility treatment started too early, in couples with unexplained infertility who were eligible for tailored expectant management? Overtreatment occurred in 36% of couples with unexplained infertility who were eligible for an expectant management of at least 6 months. Prognostic models in reproductive medicine can help to identify infertile couples that would benefit from fertility treatment. In couples with unexplained infertility with a good chance of natural conception within 1 year, based on the Hunault prediction model, an expectant management of 6-12 months, as recommended in international fertility guidelines, prevents unnecessary treatment. A retrospective cohort study in 25 participating clinics, with follow-up of all couples who were seen for infertility in 2011-2012. In all, 9818 couples were seen for infertility in the participating clinics. Couples were eligible to participate if they were diagnosed with unexplained infertility and had a good prognosis of natural conception (>30%) within 1 year based on the Hunault prediction model. Data to assess overtreatment were collected from medical records. Multilevel regression analyses were performed to investigate associations of overtreatment with patient and clinic characteristics. Five hundred and forty-four couples eligible for expectant management were included in this study. Among these, overtreatment, i.e. starting medically assisted reproduction within 6 months, occurred in 36%. The underlying quality indicators showed that in 34% no prognosis was calculated and that in 42% expectant management was not recommended. Finally, 16% of the couples for whom a correct recommendation of expectant management for at least 6 months was made, started treatment within 6 months anyway. Overtreatment was associated with childlessness, higher female age and a longer duration of infertility. No associations between overtreatment and clinic characteristics were found. The

  18. 多囊卵巢综合征不孕患者的助孕方法分析%Analysis of assisted reproduction methods for infertile patients with polycystic ovary syndrome

    Institute of Scientific and Technical Information of China (English)

    姚凤媚; 黄少娥; 姚敏玲

    2014-01-01

    目的:探讨多囊卵巢综合征不孕患者的助孕方法。方法采用回顾性分析的方法,分析2012年1月~2014年1月在花都区妇幼保健院经治的98例因患有多囊卵巢综合征而不孕的患者的临床资料,针对每位患者发生不孕的原因,并采取相应的治疗,如调整生活方式、促排卵治疗、手术治疗以及辅助生殖。结果在本组98例不孕患者中,经过治疗成功妊娠的患者91例,治疗有效率为92.86%。结论对于多囊卵巢综合征不孕患者采取的调整生活方式、促排卵治疗、手术治疗以及辅助生殖等治疗临床效果好,有利于患者正常妊娠。%Objective To explore the efficacy of assisted reproduction methods for infertile patients with polycystic ovary syndrome. Methods 98 infertility patients that suffering from polycystic ovary syndrome in Huadu District MCH from January 2012 to January 2014,their clinical data were retrospectively analyzed, the patients were given appropriate treatment for different causes of infertility,such as lifestyle adjustments,ovulation induction therapy,surgery and assisted reproductive therapy. Results There were 91 infertility patients with polycystic ovary syndrome successful pregnancy after the treatment,the effective rate was 92.86%. Conclusion it have get better clinical efficacy of lifestyle adjustments,ovulation induction therapy, surgery and assisted reproductive therapy for infertile patients with polycystic ovary syndrome,it conducive to patients with normal pregnancy.

  19. Pituitary gonodal axis in fertile and infertile human males

    Energy Technology Data Exchange (ETDEWEB)

    Hafiez, A.A.; Mahmoud, K.Z.; Abbas, E.Z.; Halawa, F. (Cairo Univ. (Egypt))

    1984-08-01

    Radioimmunoassays of serum PRL, LH, FSH, testosterone and estradiol were performed in normal fertile subjects and infertile patients. The findings in the fertile group suggest that prolactin in human males has a role in steroidogenesis. Oligospermic and azospermic patients revealed hormonal patterns which were significantly higher than in the fertile group. Hyperprolactinemia was found in most cases of both infertile groups indicating that PRL has a significant role.

  20. Chronic endometritis and infertility.

    Science.gov (United States)

    Park, Hyun Jong; Kim, You Shin; Yoon, Tae Ki; Lee, Woo Sik

    2016-12-01

    Chronic endometritis (CE) is a condition involving the breakdown of the peaceful co-existence between microorganisms and the host immune system in the endometrium. A majority of CE cases produce no noticeable signs or mild symptoms, and the prevalence rate of CE has been found to be approximately 10%. Gynecologists and pathologists often do not focus much clinical attention on CE due to the time-consuming microscopic examinations necessary to diagnose CE, its mild clinical manifestations, and the benign nature of the disease. However, the relationship between CE and infertility-related conditions such as repeated implantation failure and recurrent miscarriage has recently emerged as an area of inquiry. In this study, we reviewed the literature on the pathophysiology of CE and how it may be associated with infertility, as well as the literature regarding the diagnosis and treatment of CE. In addition, we discuss the value of hysteroscopic procedures in the diagnosis and treatment of CE.

  1. Chronic endometritis and infertility

    Science.gov (United States)

    Park, Hyun Jong; Kim, You Shin; Yoon, Tae Ki

    2016-01-01

    Chronic endometritis (CE) is a condition involving the breakdown of the peaceful co-existence between microorganisms and the host immune system in the endometrium. A majority of CE cases produce no noticeable signs or mild symptoms, and the prevalence rate of CE has been found to be approximately 10%. Gynecologists and pathologists often do not focus much clinical attention on CE due to the time-consuming microscopic examinations necessary to diagnose CE, its mild clinical manifestations, and the benign nature of the disease. However, the relationship between CE and infertility-related conditions such as repeated implantation failure and recurrent miscarriage has recently emerged as an area of inquiry. In this study, we reviewed the literature on the pathophysiology of CE and how it may be associated with infertility, as well as the literature regarding the diagnosis and treatment of CE. In addition, we discuss the value of hysteroscopic procedures in the diagnosis and treatment of CE. PMID:28090456

  2. Female infertility: role of vaginal hormonal cytology, endometrial biopsy and endocrinological evaluation.

    Science.gov (United States)

    Afroz, Nishat; Singh, Mamta; Verma, Manju; Bansal, Vandana

    2006-03-01

    Female infertility can be categorised into those who fail to ovulate (anovulatory infertility) because of some defect at hypothalamic-pituitary-ovarian axis and those who are ovulatory (ovulatory infertility), but are infertile because of some lesion present in genital tract. The role of vaginal hormonal cytology, endometrial biopsy and endocrinological evaluation in the detection of ovulation and various ovulatory dysfunction was studied in 42 infertile female patients. On the basis of cytological findings, of the 42 patients, 14 were found to be ovulatory, 26 anovulatory (which include 5 cases of atrophic changes) and 2 inconsistent due to inflammatory changes. Endometrial biopsy showed evidence of ovulation in 15, anovulation in 27 cases. Hormonal evaluation indicated some sort of endocrinological disorders in 15 patients, which may underlie anovulatory infertility in these patients, while results were within normal range in the rest 27 patients. Results of vaginal cytology and endometrial biopsy showed correlation in respect to ovulation in 93.33% of the cases.

  3. Expression of endometrial leukaemia inhibitory factor gene in patients with unexplained infertility%原因不明性原发不孕患者子宫内膜白血病抑制因子基因的表达

    Institute of Scientific and Technical Information of China (English)

    郭晓霞; 程绮馨; 王应雄

    2001-01-01

    Objective To investigate the expression of endometrial leukaemia inhibitory factor(LIF) gene in patients with unexplained infertility. Methods  By a quantitative reverse transcription-polymerase chain reaction (RT-PCR),the expression of LIF gene on endometrium during mid-luteal phase was detected in 35 unexplained infertility (infertility group) cases and 20 infertile cases due to tubal obstruction or male factor (control group). Results The level of LIF mRNA expression on endometrium during mid-luteal phase in infertility group was 0.448±0.239,significantly lower than those in the control group (1.093±0.761,P<0.01). Conclusions Our findings suggested LIF might play an important role in the process of implantation. The decreased expression of LIF gene might be one of the major causes of unexplained infertility.%目的探讨白血病抑制因子(LIF)基因在子宫内膜的表达与原因不明性原发不孕的关系。方法采用逆转录聚合酶链反应(RT-PCR)技术,对35例原因不明性原发不孕患者(病例组)和20例继发不孕患者(对组照)的黄体中期子宫内膜行LIF mRNA检测。结果对照组患者黄体中期LIF mRNA表达水平为1.093±0.761(±s,下同),病例组患者为0.448±0.239,两组相比,差异有极显著性(P<0.01)。结论 LIF可能参与了胚泡着床过程。LIF的基因表达缺陷或减弱,可能是导致原因不明性原发不孕的原因之一。

  4. Fertility prognosis for infertile couples

    DEFF Research Database (Denmark)

    Bostofte, E; Bagger, P; Michael, A

    1993-01-01

    OBJECTIVE: To develop a fertility prognosis model for infertile couples. DESIGN: Prospective follow-up study. PARTICIPANTS: In the period November 30, 1977 to June 1, 1985, 321 consecutive couples were investigated for infertility at Hvidovre University Hospital. Investigation of the female...... MEASURE: The Cox regression model was used to predict the time required to conceive based on informations provided by fertility investigations. RESULTS: Three of 16 prognostic variables (the period of infertility, the female infertility factor, and the P-test) possess significant prognostic information....... The period of infertility and the P-test are best scored as continuous variables, whereas the female infertility factor are best categorized in four classes, i.e., normal, ovulation or cervical disorder, anatomic disorder, or a combination of disorders. CONCLUSIONS: The three prognostic variables...

  5. Polycystic ovaries and infertility: Our experience

    OpenAIRE

    Lavanya Rajashekar; Deepika Krishna; Madhuri Patil

    2008-01-01

    Background: Polycystic ovary syndrome (PCOS) is one of the most common (15-20%) endocrine disorders in women of childbearing age. Although it is a major cause of infertility, its etiology remains unknown and its treatment difficult. Aim: To evaluate the incidence, treatment and outcome of patients with PCOS. DESIGN: Retrospective analysis. Materials and Methods: PCOS patients (914 of the 1057) attending the outpatient department (OPD) from June 2003 to February 2008 were evaluated for this ...

  6. 非肥胖型PCOS不孕患者超声测量肥胖指标的临床研究%Clinical study on obese indexes measured by ultrasonography in infertile patients with non-obese PCOS

    Institute of Scientific and Technical Information of China (English)

    何冰; 万里凯; 谭卫红; 陆建柳; 覃捷; 滕敏; 覃利华

    2013-01-01

    目的:探讨体重指数(BMI)正常的不孕症患者中,多囊卵巢综合征(Polycystic Ovary Syndrome,PCOS)即非肥胖型PCOS (NOB-PCOS)与非PCOS(对照组)患者之间内脏脂肪厚度(visceral fat thicknes,VFT)及判断肥胖相关的人体测量值的差异,为更好地治疗NOB-PCOS不孕症提供依据.方法:检测不孕症患者中BMI正常的140例PCOS及81例非P-COS患者的基础性激素,用超声检测腹部皮下脂肪、内脏脂肪、肝前脂肪、肝前皮下脂肪厚度,测量身高、体重、腹围、腰围、臀围等,对两组间上述指标进行分析.结果:NOB-PCOS组血清促黄体生成素(LH)、睾酮(T)明显高于非PCOS组(P<0.05);NOB-PCOS组腹围、腹部皮下脂肪厚度及内脏脂肪厚度明显高于非PCOS组(P<0.05).结论:NOB-PCOS不孕症患者腹围、腹部皮下脂肪及内脏脂肪厚度等判断肥胖的指标大于非PCOS患者,治疗时应引起重视.%Objective:To explore the differences of visceral fat thickness (VFT) and obesity-related body measurements between infertile patients with normal body mass index (BMI) and polycystic ovary syndrome (PCOS) and infertile patients with normal BMI and without PCOS,and provide a basis for cure infertile patients with non-obese PCOS.Methods:The levels of basic sex hormones in 140 infertile patients with PCOS and normal BMI and 81 infertile patients with normal BMI,ultrasound was used to detect the thicknesses of abdominal subcutaneous fat,visceral fat,prehepatic fat and prehepatic subcutaneous fat; body height,body weight,abdominal circumference,waist circumference and hip circumference were measured; the above-mentioned indexes in the two groups were analyzed.Results:The serum levels of luteinizing hormone (LH) and testosterone in non-obese PCOS group were statistically significantly higher than those in non -PCOS group (P < 0.05) ; abdominal circumference,abdominal subcutaneous fat thickness and visceral fat thickness in non-obese PCOS group were

  7. Need for accessible infertility care in Ghana: the patients’ voice

    Science.gov (United States)

    Osei, Nana Yaw

    2016-01-01

    Abstract According to the Ghana Statistical Service (GSS) infertility and childlessness are the most important reason for divorce in Ghana. The traditional Ghanaian society is pro-natal and voluntary childlessness is very uncommon. Patient groups are almost non-existent in Sub-Saharan Africa, aggravating the situation of childless couples. Due to the lack of enough and affordable high quality infertility services, many women resort to traditional healing, witchcraft and spiritual mediation. Considering the severe sociocultural and economic consequences of childlessness, especially for women, there is an urgent need for accessible and affordable high quality infertility care in Ghana. PMID:27909570

  8. Chromosomal polymorphisms are associated with female infertility and adverse reproductive outcomes after infertility treatment: a 7-year retrospective study.

    Science.gov (United States)

    Cheng, Ran; Ma, Yaxian; Nie, Ying; Qiao, Xiaoyong; Yang, Zhilan; Zeng, Rujun; Xu, Liangzhi

    2017-07-01

    Data from 19,950 women were retrospectively analysed to determine the effect of chromosomal polymorphisms on female infertility and pregnancy outcome; fertile women were used as controls. Frequency of chromosomal polymorphisms and adverse pregnancy outcomes were compared between groups. A significantly higher incidence of chromosomal polymorphisms was found in total infertile patients, and patients with tubal infertility, ovulatory dysfunction, cervical and uterine abnormalities, and unexplained infertility compared with controls (5.53% [P Infertile women had a higher incidence of 9qh+ and inv(9) compared with controls (P chromosomal polymorphisms on female infertility (adjusted OR 1.662, 95% CI 1.551 to 1.796, P infertility groups, miscarriage rates were higher in women with chromosomal polymorphisms than in women with normal chromosomes (4.95% versus 0.96%, P = 0.001 and 6.17% versus 1.08%, P Chromosomal polymorphisms adversely affected spontaneous miscarriage rates (adjusted OR 1.625, 95% CI 1.514 to 1.769, P = 0.005). Copyright © 2017 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

  9. Germ cell transplantation in infertility mouse

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    This work investigated the spermatogenesis in an infertility BALB/c-nu mouse model by reinfusing germline stem cells into seminiferous tubules.Donor germ cells were isolated from male FVB/NJ-GFP transgenic mice.Seminiferous tubule microiniection was applied to achieve intratubular germ cell transfer.The germ cells were injected into exposed testes of the infertility mice.We used green fluorescence and DNA analysis of donor cells from GFP transgenic mice as genetic marker.The natural mating and Southern blot methods were applied to analyze the effect of sperm cell transplantation and the sperm function after seminiferous tubule microinjecUon.The spermatogenesis was morphologically observed from the seminiferous tubules in 41/60(68.33%)of the injected recipient mice using allogeneic donor cells.In the colonized testes,matured spermatozoa were seen in the lumen of the seminiferous tubules.In this research,BALB/c-nu infertility mouse model,the recipient animal,was used to avoid immunological rejection of donor cells,and germ cell transplantation was applied to overcome infertility caused by busulfan treatment.These results demonstrate that this technique of germ cell transplantation is of great use.Germ cell transplantation could be potentially valuable to oncological patients.

  10. Y chromosome microdeletions in Turkish infertile men

    Directory of Open Access Journals (Sweden)

    Zamani Ayse

    2006-01-01

    Full Text Available AIMS: To detect the frequency and types of both chromosomal abnormalities and Y chromosome microdeletions in infertile men attending to our university intracytoplasmic sperm injection ICSI/IVF centre and fertile control subjects in our patient population. SETTINGS AND DESIGN: A total of 50 infertile men who were referred to IVF center of Meram medical faculty were selected for the molecular azospermia factor (AZF screening program. MATERIALS AND METHODS: Karyotype analysis and polymerase chain reaction amplification using 15 Y-specific sequence-tagged sites of AZF region were done. RESULTS: The total prevalence of chromosomal abnormalities was found to be 10% (5/50, including 4 patients with numerical and 1 patient with structural abnormalities. Overall, 4 of the 50 patients tested (8% exhibited deletions of the Y chromosome, 3 of them being azospermic and 1 of them oligospermic men. The frequency of the microdeletions in subgroups with azospermia and oligozoospermia was found to be 10.7% (3/29 and 4.7% (1/21 respectively. Microdeletions of AZFb and AZFc regions were detected in all of the 4 patients. Neither AZFa nor AZFd microdeletions were indicated. CONCLUSIONS: Our findings suggest that one must know whether there is a genetic cause for male infertility before patients can be subjected to ISCI or testicular sperm extraction (TESE/ISCI treatment.

  11. Quality and quantity of infertility care in Bangladesh.

    Science.gov (United States)

    Fatima, P; Ishrat, S; Rahman, D; Banu, J; Deeba, F; Begum, N; Anwary, S A; Hossain, H B

    2015-01-01

    Infertility is an important health issue which has been neglected in the developing countries. First test-tube babies (triplet) in Bangladesh were born on 30th May, 2001. Although there is no tertiary level infertility center in the public sector, several private centers have come up with the facilities. The objective of the study was to find i) the quality and quantity of infertility care in Bangladesh and ii) the cause of infertility in the attending patients iii) the treatment seeking behaviors iv) and the reasons for not taking treatment among the attending patients. There are now 10 tertiary level Infertility centers in Bangladesh. The information was collected in a preformed datasheet about the facilities and the profile of the patients and the treatment seeking behavior of the attending patients. Out of the ten centers two centers refused to respond and did not disclose their data. Around 16700 new patients are enrolled in a year in the responsive clinics. Five percent (5%) of the patients underwent ART, 7% of the patients gave only one visit, 84% of the patients completed their evaluation, 76% of the patients took treatment. Causes of infertility in the patients taking treatment were male factor in 36.4%, bilateral tubal block in 20.2%, PCOS and anovulation in 31.7%, endometriosis in 19.6%, unexplained in 10.95, combined in 3.5%, ovarian failure in 1.4%, testicular failure in 0.33%, congenital anomaly in 0.3%. The main reason for not taking treatment was financial constrainment. The quality and quantity of infertility care is dependent on the available resources and on the use of the resources by the patients. In developing countries the resources are merging and confined to specified areas which cannot meet the demand of their population. The study gives us the idea of the need and the demand of the services in the country.

  12. Genetics Home Reference: Y chromosome infertility

    Science.gov (United States)

    ... Home Health Conditions Y chromosome infertility Y chromosome infertility Enable Javascript to view the expand/collapse boxes. ... PDF Open All Close All Description Y chromosome infertility is a condition that affects the production of ...

  13. Analysis of Androgen Receptor Gene Mutations in female with infertility

    Directory of Open Access Journals (Sweden)

    Soyar Sari

    2017-06-01

    Full Text Available Background : Infertility is a multifactorial disease. Hormonal disorders and genetic factors are important in female infertility. Development and maturation of ovulation are depending on the molecular signaling pathways in response to androgens. Over hundreds of mutations leading to resistance gene function in androgen receptor (AR has been recorded. One of them is polymorphic region 5'UTR. Thus regarding to the role of androgen receptor in infertility, the aim of the present study was to investigate the association between gene mutations AR and infertility in Iranian women Materials and Methods: In this study of 50 infertile women and 80 healthy women as a control, blood samples were taken. After extraction of DNA, PCR method was used to determine the AR gene mutations. Results: In the present study in '5UTR area at position +25 androgen receptor gene a T nucleotide deletion was observed. , therefore single nucleotide mutations did not change in the androgen receptor gene expression, so indicates the lack of communication between the AR gene mutations in the promoter region of 23 to 214+ in women with infertility. According to the results of this study are significant differences between the two groups of patients and healthy women was not found (P=0.5. Conclusion: Results indicated no correlation between mutations in the promoter region of 23 to 214+ AR genes in the population studied women with infertility

  14. Models Predicting Success of Infertility Treatment: A Systematic Review

    Science.gov (United States)

    Zarinara, Alireza; Zeraati, Hojjat; Kamali, Koorosh; Mohammad, Kazem; Shahnazari, Parisa; Akhondi, Mohammad Mehdi

    2016-01-01

    Background: Infertile couples are faced with problems that affect their marital life. Infertility treatment is expensive and time consuming and occasionally isn’t simply possible. Prediction models for infertility treatment have been proposed and prediction of treatment success is a new field in infertility treatment. Because prediction of treatment success is a new need for infertile couples, this paper reviewed previous studies for catching a general concept in applicability of the models. Methods: This study was conducted as a systematic review at Avicenna Research Institute in 2015. Six data bases were searched based on WHO definitions and MESH key words. Papers about prediction models in infertility were evaluated. Results: Eighty one papers were eligible for the study. Papers covered years after 1986 and studies were designed retrospectively and prospectively. IVF prediction models have more shares in papers. Most common predictors were age, duration of infertility, ovarian and tubal problems. Conclusion: Prediction model can be clinically applied if the model can be statistically evaluated and has a good validation for treatment success. To achieve better results, the physician and the couples’ needs estimation for treatment success rate were based on history, the examination and clinical tests. Models must be checked for theoretical approach and appropriate validation. The privileges for applying the prediction models are the decrease in the cost and time, avoiding painful treatment of patients, assessment of treatment approach for physicians and decision making for health managers. The selection of the approach for designing and using these models is inevitable. PMID:27141461

  15. Cardiovascular risk may be increased in women with unexplained infertility.

    Science.gov (United States)

    Verit, Fatma Ferda; Yildiz Zeyrek, Fadile; Zebitay, Ali Galip; Akyol, Hurkan

    2017-03-01

    Growing evidence suggests that increased cardiovascular disease (CVD) risk is associated with female infertility caused by conditions such as polycystic ovarian disease, obesity, thyroid dysfunction, and endometriosis. The aim of this study was to evaluate whether any relationship exists between CVD and unexplained infertility. Sixty-five women with unexplained infertility and 65 fertile controls were enrolled in the study. CVD risk markers such as low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), triglycerides (TG), insulin resistance (defined by the homeostasis model assessment ratio), and high-sensitivity C-reactive protein (hs-CRP) were assessed. TG, TC, LDL, and hs-CRP levels were higher and HDL levels were lower in patients with unexplained infertility than in fertile controls (p<0.05 for all). Positive associations were found between unexplained infertility and TG, TC, LDL, and hs-CRP levels, and a negative correlation was found for HDL (p<0.05 for all). Multivariate logistic regression analysis showed that TG, HDL, and hs-CRP were independent variables associated with unexplained infertility. Our study showed that women with unexplained infertility had an atherogenic lipid profile and elevated hs-CRP levels, suggesting a higher risk of developing CVD in the future. Further studies with larger groups are needed to investigate the nature of this link.

  16. EVIDENCE BASED INCIDENCE OF TUBAL FACTOR IN SECONDARY INFERTILITY AS DETECTED BY HYSTEROSALPINGOGRAPHY IN WESTERN MAHARASHTRA

    Directory of Open Access Journals (Sweden)

    Anil

    2016-05-01

    Full Text Available BACKGROUND It is documented that 15% of all women experience primary or secondary infertility at one point in time in their reproductive life. Tubal causes of infertility account for 35 to 40% of causes of infertility. HSG is still a commonly used investigation in the evaluation of the female genital tract and the main indication for the HSG is infertility. AIMS  To find out incidence of tubal factor in secondary infertility in Western Maharashtra population.  To establish reliability of Hysterosalpingography in evaluating tubal status. MATERIALS AND METHOD A retrospective study of 464 hysterosalpingographies of women having secondary infertility was done over period of two years. The patients having tubal defects were further studied and statistically analysed. Statistical analysis was performed with the SPSS computer software, version 17.0. Results were presented in tables and graphs. RESULTS  Hysterosalpingography has proved to be an ideal (or ‘gold standard’ test to detect tubal abnormalities in infertile women.  The commonest structural cause of infertility in Western Maharashtra as per this study was bilateral tubal blockage and was commoner in patients with secondary infertility. CONCLUSIONS Evaluation of tubal patency and tubal integrity is a key component of the diagnostic work-up in infertile couples. In conclusion, bilateral tubal occlusion remains the major tubal pathology in female infertility in Western Maharashtra. Tubal blockages with subsequent tubal factor infertility are still common among infertile couples. This may probably be due to chronic pelvic inflammatory disease or pelvic infection following sexually transmitted infections, mismanaged pregnancies and septic abortions, since the majority of the women presented with secondary infertility. Measures to prevent the occurrence of these infections should be paramount.

  17. Clinical Analysis of Thyroid Function in Patients with Infertility Screening%不孕症患者甲状腺功能筛查的临床分析

    Institute of Scientific and Technical Information of China (English)

    李善凤; 莫应萍

    2015-01-01

    Objective:To investigate the relevance of hypothyroidism associated with adverse pregnancy history,the role of thyroid function tests in clinical treatment of infertility.Method:Thyroid function was detected in 190 patients with ovarian factor infertility,as the sterility group;and compared with the same period outpatient physical examination female 190 cases control,as the physical examination group.Result:There were six types in the sterility group,hyperthyroidism had 5 cases,accounted for 2.63%;clinical hyperthyroidism had 4 cases,accounted for 2.11%;subclinical hyperthyroidism had 1 case,accounted for 0.53%;hypothyroidism had 11cases,accounted for 5.79%;clinical hypothyroidism had 1 case,accounted for 0.53%;subclinical hypothyroidism had 10 cases,accounted for 5.26%.There were six types in the physical examination group,hyperthyroidism had 3 cases,accounted for 1.58%;clinical hyperthyroidism had 2 cases,accounted for 1.05%;subclinical hyperthyroidism had 1 case,accounted for 0.53%;hypothyroidism had 2 cases,accounted for 1.05%;clinical hypothyroidism had 1 case,accounted for 0.53%;subclinical hypothyroidism had 1 case,accounted for 0.53%.The thyroid dysfunction in the sterility group was obviously higher than that of the physical examination group,the proportion of hypothyroidism patients in the sterility group was significantly higher than that of the physical examination group(P<0.05).Conclusion:Hypothyroidism is associated with adverse pregnancy history have significant correlation,thyroid function screening during infertile patients is necessary.%目的:探讨甲状腺功能减退与不良孕产史的相关性,甲状腺功能检测在临床诊治不孕症中的作用.方法:对190例因卵巢因素不孕的患者行甲状腺功能检测,作为不孕组;并与同期门诊体检女性190例对照,作为体检组.观察比较两组甲状腺情况.结果:不孕组患者包括6种情况,甲状腺功能亢进5例(2.63%);临床型甲状腺功能亢进4例(2

  18. Infertility, infertility treatment and twinning: the Danish National Birth Cohort

    DEFF Research Database (Denmark)

    Zhu, Jin Liang; Basso, Olga; Obel, Carsten

    2007-01-01

    BACKGROUND: We have previously observed that an increasing time to pregnancy (TTP) is associated with a reduced frequency of twin deliveries in couples not receiving infertility treatment. By using updated information, we assessed the frequencies of dizygotic (DZ) and monozygotic (MZ) twin...... deliveries as a function of infertility (TTP > 12 months), as well as infertility treatment. METHODS: From the Danish National Birth Cohort (1997-2003), we identified 51 730 fertile couples with TTP 12 months and 5163 infertile couples who conceived after treatment. Information on zygosity, available...... for part of the cohort (1997-2000), was based on standardized questions on the similarities between the twins at the age of 3-5 years. RESULTS: Compared with fertile couples, the frequency of DZ twin deliveries was lower for infertile couples conceiving naturally (odds ratio 0.4, 95% confidence interval 0...

  19. Male Infertility: MedlinePlus Health Topic

    Science.gov (United States)

    ... Retrograde ejaculation Semen analysis Sperm release pathway Testicular biopsy Related Health Topics Assisted Reproductive Technology Female Infertility Infertility National Institutes of Health The ...

  20. Hijama (wet cupping) for female infertility treatment: a pilot study

    OpenAIRE

    Hassan Abduljabbar; Anhar Gazzaz; Samiha Mourad; Ayman Oraif

    2016-01-01

    Background: To assess the effectiveness of wet cupping (Hijama) as a treatment of female factor infertility. The primary outcome measured was pregnancy rates after Hijama. The secondary outcome measured was the effect on the reproductive hormonal profile before and after Hijama. Methods: A pilot clinical study was conducted for the use of Hijama as treatment for female infertility at King Abdulaziz University Hospital from September 2013 to May 2015. Inclusion criteria included: patients w...

  1. Perspectives of complementary and alternative medicine (CAM) practitioners in the support and treatment of infertility.

    Science.gov (United States)

    O'Reilly, Erin; Sevigny, Marika; Sabarre, Kelley-Anne; Phillips, Karen P

    2014-10-14

    Infertility patients are increasingly using complementary and alternative medicine (CAM) to supplement or replace conventional fertility treatments. The objective of this study was to determine the roles of CAM practitioners in the support and treatment of infertility. Ten semi-structured interviews were conducted in Ottawa, Canada in 2011 with CAM practitioners who specialized in naturopathy, acupuncture, traditional Chinese medicine, hypnotherapy and integrated medicine. CAM practitioners played an active role in both treatment and support of infertility, using a holistic, interdisciplinary and individualized approach. CAM practitioners recognized biological but also environmental and psychosomatic determinants of infertility. Participants were receptive to working with physicians, however little collaboration was described. Integrated infertility patient care through both collaboration with CAM practitioners and incorporation of CAM's holistic, individualized and interdisciplinary approaches would greatly benefit infertility patients.

  2. Infertility despite surgery for cryptorchidism in childhood can be classified by patients with normal or elevated follicle-stimulating hormone and identified at orchidopexy

    DEFF Research Database (Denmark)

    Cortes, D; Thorup, J; Lindenberg, S;

    2003-01-01

    42 formerly bilateral cryptorchid boys had repeat testicular biopsies taken. Infertility was suspected in men with sperm/mL in the best sample of semen and concomitant poor sperm motility, and who were classified by follicle-stimulating hormone (FSH) values. At orchidopexy the number...

  3. Symptomatic sick sinus syndrome requiring permanent pacemaker implantation in a patient uwith mirror image dextrocardia with situs inversus and infertility.

    Science.gov (United States)

    Kahali, Dhiman; Mandal, Saroj; Mandal, Debasmita; Ghose, Arijit; Kanjilal, Souvik

    2013-01-01

    Situs inversus with dextrocardia is a congenital condition in which the heart is a mirror image of the anatomically normal heart on the right side. A patient presented with the sick sinus syndrome accompanying mirror image dextrocardia which was associated with double superior vena cava and a left sided inferior vena cava A permanent transvenous demand pacemaker was inserted because of repeated episodes of dizziness and a single episode of syncope with ECG showing bradycardia with junctional escape rhythm. Precise knowledge of the venous system and the location of the apex of the right ventricle were necessary prior to permanent pacemaker implantation. Without such knowledge pacing may be technically challenging.

  4. Differential expression of VASA gene in ejaculated spermatozoa from normozoospermic men and patients with oligozoospermia%生殖细胞特异基因VASA在正常和少精子症患者精子中的表达研究

    Institute of Scientific and Technical Information of China (English)

    Xin Guo; Yao-Ting Gui; Ai-Fa Tang; Li-Hua Lu; Xin Gao; Zhi-Ming Cai

    2007-01-01

    Aim: To detect the expression of VASA in human ejaculated spermatozoa, and to compare the expression of VASA between normozoospermic men and patients with oligozoospermia. Methods: Ejaculated spermatozoa were collected from normozoospermic men and patients with oligozoospermia by masturbation, and subsequently segregated through a discontinuous gradient of Percoll to obtain the spermatozoa. Reverse transcription polymerase chain reaction (RT-PCR), quantitative RT-PCR (QRT-PCR), immunoflurescence and Western blotting were used to detect the expression of VASA in mRNA and protein levels. Results: VASA mRNA was expressed in the ejaculated spermatozoa. QRT-PCR analysis showed that VASA mRNA level was approximately 5-fold higher in normozoospermic men than that in oligozoospermic men. Immunofluorescence and Western blotting analysis showed that VASA protein was located on the cytoplasmic membrane of heads and tails of spermatozoa, and its expression was significantly decreased in oligozoospermic men, which is similar to the result of QRT-PCR. Conclusion: The expression of VASA mRNA and protein was significantly decreased in the sperm of oligozoospermic men, which suggested the lower expression of the VASA gene might be associated with pathogenesis in some subtypes of male infertility and VASA could be used as a molecular marker for the diagnosis of male infertility.%目的:探讨生殖细胞高度特异性基因VASA在正常和少精子症患者精子中的表达,明确该基因在精子发生中的作用和相关机制.方法:正常和少精子症患者精液通过Percoll梯度分离获得精子.采用RT-PCR、realtime PCR、Western blot和免疫荧光方法分析该基因转录产物和蛋白表达.结果:VASA mRNA在射出精子中表达,正常精子VASA mRNA水平是少精子症精子的5倍;免疫荧光显示VASA蛋白主要定位在精子头部质膜和尾部,其表达强度正常组明显高于病变组,Western blot结果与免疫荧光结果相一致.结论:少

  5. Changes in the sex hormone level in serum of infertility female patients%女性不孕症患者血清性激素水平的变化及临床意义

    Institute of Scientific and Technical Information of China (English)

    芮燕文; 郑彤彤; 戴婵娟; 朱文娇

    2015-01-01

    Objectives:To explore the change and clinical significance of the sex hormone level in serum of infertility female patients.Methods:Retrospective analysis was conducted on the changes of sex hormone level in serum of 1 1 8 infertility female patients (including 38 eumenorrhea patients and 80 irregular menstruation patients) and 78 healthy women who were as the control group.The sex hormone changes of infertility patients with irregular menstruation were compared with the control group.Results:Comparing eumenorrhea infertility patients with healthy women,FSH,LH,PRL,T,E2 and P level increased,with no significant difference (P>0. 05 ).Compa-ring irregular menstruation infertility patients with healthy women,there was significant increase in FSH,LH,PRL and P level (P<0. 05 )and decrease in E2 (P<0. 05 ).Comparing irregular menstruation infertility patients with control group,there was significant increase in FSH,LH,PRL and P level(P<0. 05 )in hyperprolactinemia and pituitary microadenoma patients as well as decrease in E2 (P<0. 05 ).For Uterine ovarian dysfunction patients, there was significant increase in LH,PRL and P level (P<0. 05 ).For corpus luteum dysfunction patients,there was significant increase in LH and P level (P<0. 05 ).Conclusion:Pathogenic factors of irregular menstruation infertility patients are associated with endocrine disorder,but eumenorrhea infertility patients may be not totally as-sociated with endocrine disorder and other causes may be included.The changes in sex hormone in serum may serve as diagnostic basis for irregular infertility patients.%目的:探讨女性不孕症患者血清性激素水平的变化及临床意义。方法:回顾性分析118例不孕症患者(月经正常组38例,月经异常组80例)与78例健康对照组个体血清性激素水平的变化,并将病因明确的月经异常不孕症患者的血清性激素水平与对照组比较。结果:月经正常不孕症患者与对照组相比, FSH

  6. Detection of invariant natural killer T cells in ejaculates from infertile patients with chronic inflammation of genital tract.

    Science.gov (United States)

    Duan, Yong-Gang; Chen, Shujian; Haidl, Gerhard; Allam, Jean-Pierre

    2017-04-03

    Chronic inflammation of genital tract is thought to play a major role in male fertility disorder. Natural killer (NK) T cells are a heterogeneous group of T cells that share properties of both T cells and NK cells which display immunoregulatory properties. However, little is known regarding the presence and function of NK T cells in ejaculates from patients with chronic inflammation of genital tract. Invariant NK T (iNK T) cells were detected by invariant (Vα24-JαQ) TCR chain in ejaculates from patients suffering from chronic inflammation of genital tract (CIGT) using flow cytometry and immunofluorescence of double staining (n=40). Inflammatory cytokines interleukin (IL)-6, IL-17, and IFN-γ were detected in cell-free seminal plasma using an enzyme-linked immunosorbent assay (ELISA). The correlation between the percentage of iNK T cells and spermatozoa count, motility, vitality, seminal IL-6, IL-17, and IFN-γ was investigated. Significant percentages of iNK T cells above 10% were detected in 50% (CIGT-NKT(+) group). A negative correlation was detected between the percentage of iNK T cells and spermatozoa count (r=-.5957, P=.0056), motility (r=-.6163, P=.0038), and vitality (r=-.8032, P=.0019) in CIGT-NKT(+) group (n=20). Interestingly, a significant correlation of iNK T cells to seminal IL-6 (r=.7083, P=.0005), IFN-γ (r=.9578, PT cells and IL-17 (r=-.1557, P=.5122) in CIGT-NKT(+) group. The proliferative response of iNK T cells could accompany an inflammatory response to spermatozoa and consequently influence sperm quality through secretion of IFN-γ but not IL-17 under chronic inflammatory condition.

  7. Prevalence of Chromosomal Abnormalities in Infertile Couples in Romania

    Directory of Open Access Journals (Sweden)

    Mierla Dana

    2015-06-01

    Full Text Available The purpose of this study was to establish a correlation between the presence of chromosomal abnormalities in one of the partners and infertility. This retrospective study was performed at the Department of Reproductive Medicine, Life Memorial Hospital, Bucharest, Romania, between August 2007 to December 2011. Two thousand, one hundred and ninety-five patients with reproductive problems were investigated, and the frequency of chromosomal abnormalities was calculated. The control group consisting of 87 fertile persons who had two or more children, was investigated in this retrospective study. All the patients of this study were investigated by cytogenetic techniques and the results of the two groups were compared by a two-tailed Fisher’s exact test. In this study, 94.99% patients had a normal karyotype and 5.01% had chromosomal abnormalities (numerical and structural chromosomal abnormalities. In the study group, numerical chromosomal abnormalities were detected in 1.14% of infertile men and 0.62% of infertile women, and structural chromosomal abnormalities were detected in 1.38% of infertile men and 1.87% of infertile women, respectively. The correlation between the incidence of chromosomal anomalies in the two sexes in couple with reproductive problems was not statistically significant. Recently, a possible association between infertility and chromosomal abnormalities with a significant statistical association has been reported. Our study shows that there is no association between chromosomal abnormalities and infertility, but this study needs to be confirmed with further investigations and a larger control group to establish the role of chromosomal abnormalities in the etiology of infertility.

  8. Prevalence of chromosomal abnormalities in infertile couples in romania.

    Science.gov (United States)

    Mierla, D; Malageanu, M; Tulin, R; Albu, D

    2015-06-01

    The purpose of this study was to establish a correlation between the presence of chromosomal abnormalities in one of the partners and infertility. This retrospective study was performed at the Department of Reproductive Medicine, Life Memorial Hospital, Bucharest, Romania, between August 2007 to December 2011. Two thousand, one hundred and ninety-five patients with reproductive problems were investigated, and the frequency of chromosomal abnormalities was calculated. The control group consisting of 87 fertile persons who had two or more children, was investigated in this retrospective study. All the patients of this study were investigated by cytogenetic techniques and the results of the two groups were compared by a two-tailed Fisher's exact test. In this study, 94.99% patients had a normal karyotype and 5.01% had chromosomal abnormalities (numerical and structural chromosomal abnormalities). In the study group, numerical chromosomal abnormalities were detected in 1.14% of infertile men and 0.62% of infertile women, and structural chromosomal abnormalities were detected in 1.38% of infertile men and 1.87% of infertile women, respectively. The correlation between the incidence of chromosomal anomalies in the two sexes in couple with reproductive problems was not statistically significant. Recently, a possible association between infertility and chromosomal abnormalities with a significant statistical association has been reported. Our study shows that there is no association between chromosomal abnormalities and infertility, but this study needs to be confirmed with further investigations and a larger control group to establish the role of chromosomal abnormalities in the etiology of infertility.

  9. Ethical issues in infertility.

    Science.gov (United States)

    Serour, Gamal I; Serour, Ahmed G

    2017-03-01

    Infertility is a global medico-socio-cultural problem with gender-based suffering particularly in developing countries. Conventional methods of treatment for infertility do not usually raise ethical concerns. However, assisted reproductive technology (ART) has initiated considerable ethical debate, disagreement, and controversy. There are three ethical principles that provide an ethical basis for ART: the principle of liberty, principle of utility, and principle of justice. Medical ethics are based on the moral, religious, and philosophical ideas and principles of the society and are influenced by economics, policies, and law. This creates tension between the principles of justice and utility, which can result in disparity in the availability of and access to ART services between the rich and the poor. The moral status of the embryo is the key for all the ethical considerations and law regarding ART in different societies. This has resulted in cross-border ART. Conscientious objection of healthcare providers should not deprive couples from having access to a required ART service.

  10. Thyroid dysfunction in infertile women

    Directory of Open Access Journals (Sweden)

    S G Perminova

    2011-12-01

    Full Text Available Objective. To study the rate and structure of thyroid diseases in infertile women and to asses their reproductive system depending upon the thyroid pathology. Subjects and methods. The study was based on the results of screening of T status of 496 women with infertility (main group and 80 fertile women (control group. Traditional methods of diagnosis of infertility were used along with special methods of investigation including assessment of function and structure of T (TTH, fT4, fT3, AT-TPO, AT-rTTH, ultrasound examination of T, thin-niddle aspirational biopsy, scintigraphy of T. A complex evaluation of the reproductive system status in infertile women was done depending on the type of T pathology. Results. Infertile women were found to suffer from thyroid dysfunction 3.8 times as more often as fertile ones (48% and 12.5%, p <0.05. Its structure included mainly AT-TPO carrier phenomenon in combination with ultrasound markers of thyroid autoimmunity (24%, hypothyroidism following thyroid autoimmunity (9.4% demonstrating itself as clinical (0.8%, subclinical (8.6%, and euthyroid (7.8% goiters. The portion of women with infertility and hyperthyroidism was small (0.6%. An association of thyroid autoimmunity with idiopathic infertility, endometriosis, endocrine infertility was found. Conclusion. It is necessary to perform a screening assessment of the function and structure of T in infertile women within diagnostic search for the reasons of infertility and in-time correction of the revealed thyroid dysfunction.

  11. Assessment of Correlation between Androgen Receptor CAG Repeat Length and Infertility in Infertile Men Living in Khuzestan, Iran

    Directory of Open Access Journals (Sweden)

    Saeid Reza Khatami

    2015-02-01

    Full Text Available Background: The androgen receptor (AR gene contains a polymorphic trinucleotide repeat that encodes a polyglutamine tract in its N-terminal transactivation domain (NTAD. We aimed to find a correlation between the length of this polymorphic tract and azoospermia or oligozoospermia in infertile men living in Khuzestan, Iran. Materials and Methods: In this case-control study during two years till 2010, we searched for microdeletions in the Y chromosome in 84 infertile male patients with normal karyotype who lived in Khuzestan Province, Southwest of Iran. All cases (n=12 of azoospermia or oligozoospermia resulting from Y chromosome microdeletions were excluded from our study. The number of CAG repeats in exon 1 of the AR gene was determined in 72 patients with azoospermia or oligozoospermia and in 72 fertile controls, using the polymerase chain reaction (PCR and polyacrylamide gel electrophoresis. Results: Microdeletions were detected in 14.3% (n=12 patients suffering severe oligozoospermia. The mean CAG repeat length was 18.99 ± 0.35 (range, 11-26 and 19.96 ± 0.54 (range, 12-25 in infertile males and controls, respectively. Also in the infertile group, the most common allele was 19 (26.38%, while in controls, it was 25 (22.22%. Conclusion: Y chromosome microdeletions could be one of the main reasons of male infertility living in Khuzestan Province, while there was no correlation between CAG length in AR gene with azoospermia or oligozoospermia in infertile men living in Khuzestan, Iran.

  12. A cytogenetic study of couples with recurrent spontaneous abortions and infertile patients with recurrent IVF/ICSI failure

    Directory of Open Access Journals (Sweden)

    Mozdarani Hossein

    2008-01-01

    Full Text Available Purpose: This study was conducted to determine the frequency and contribution of chromosomal abnormalities in miscarriages and in couples with recurrent in vitro fertilization/intra cytoplasmic sperm injection (IVF/ICSI failure. Materials and Methods: A total of 221 individuals; 79 with three or more recurrent spontaneous abortions and 142 with at least three IVF/ICSI failures. Chromosomal analysis from peripheral blood lymphocytes was performed according to standard cytogenetic methods using G-banding technique. Results: Abnormal karyotype was found in 21 (9.50% individuals. Of these 21 subjects, 4 (19.04% exhibited sex chromosomal abnormalities and 17 (80.96% had autosomal abnormalities. Male partners had significantly higher chromosomal abnormalities (5.88% than of females (3.61%. These abnormalities were also higher in patients with recurrent spontaneous abortions than with IVF/ICSI failure (P < 0.05. Conclusions: These data may be indicative that chromosomal abnormalities are involved more in spontaneous abortions than in recurrent IVF/ICSI failure. Cytogenetic analysis could be valuable for these couples when clinical data fail to clarify the cause.

  13. Indonesian infertility patients’ health seeking behaviour and patterns of access to biomedical infertility care: an interviewer administered survey conducted in three clinics

    Directory of Open Access Journals (Sweden)

    Bennett Linda Rae

    2012-09-01

    Full Text Available Abstract Background Indonesia has high levels of biological need for infertility treatment, great sociological and psychological demand for children, and yet existing infertility services are underutilized. Access to adequate comprehensive reproductive health services, including infertility care, is a basic reproductive right regardless of the economic circumstances in which individuals are born into. Thus, identifying and implementing strategies to improve access to assisted reproductive technology (ART in Indonesia is imperative. The principle objectives of this article are to improve our understanding of infertility patients’ patterns of health seeking behaviour and their patterns of access to infertility treatment in Indonesia, in order to highlight the possibilities for improving access. Methods An interviewer-administered survey was conducted with 212 female infertility patients recruited through three Indonesian infertility clinics between July and September 2011. Participants were self-selected and data was subject to descriptive statistical analysis. Results Patients identified a number of barriers to access, including: low confidence in infertility treatment and high rates of switching between providers due to perceived treatment failure; the number and location of clinics; the lack of a well established referral system; the cost of treatment; and patients also experienced fear of receiving a diagnosis of sterility, of vaginal examinations and of embarrassment. Women’s age of marriage and the timing of their initial presentation to gynaecologists were not found to be barriers to timely access to infertility care. Conclusions The findings based on the responses of 212 female infertility patients indicated four key areas of opportunity for improving access to infertility care. Firstly, greater patient education about the nature and progression of infertility care was required among this group of women. Secondly, increased resources

  14. Indonesian infertility patients’ health seeking behaviour and patterns of access to biomedical infertility care: an interviewer administered survey conducted in three clinics

    Science.gov (United States)

    2012-01-01

    Background Indonesia has high levels of biological need for infertility treatment, great sociological and psychological demand for children, and yet existing infertility services are underutilized. Access to adequate comprehensive reproductive health services, including infertility care, is a basic reproductive right regardless of the economic circumstances in which individuals are born into. Thus, identifying and implementing strategies to improve access to assisted reproductive technology (ART) in Indonesia is imperative. The principle objectives of this article are to improve our understanding of infertility patients’ patterns of health seeking behaviour and their patterns of access to infertility treatment in Indonesia, in order to highlight the possibilities for improving access. Methods An interviewer-administered survey was conducted with 212 female infertility patients recruited through three Indonesian infertility clinics between July and September 2011. Participants were self-selected and data was subject to descriptive statistical analysis. Results Patients identified a number of barriers to access, including: low confidence in infertility treatment and high rates of switching between providers due to perceived treatment failure; the number and location of clinics; the lack of a well established referral system; the cost of treatment; and patients also experienced fear of receiving a diagnosis of sterility, of vaginal examinations and of embarrassment. Women’s age of marriage and the timing of their initial presentation to gynaecologists were not found to be barriers to timely access to infertility care. Conclusions The findings based on the responses of 212 female infertility patients indicated four key areas of opportunity for improving access to infertility care. Firstly, greater patient education about the nature and progression of infertility care was required among this group of women. Secondly, increased resources in terms of the number and

  15. Quantification of human telomerase RNA (Htr) and human telomerase reverse transcriptase (Htert)Mrna in testicular tissue of infertile patients

    Institute of Scientific and Technical Information of China (English)

    Mark Schrader; Markus Miller; Ridiger Heicappell; Bernd Straub; Kurt Miller

    2001-01-01

    Aim: To evaluate the quantitative detection of human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT) mRNA as diagnostic parameters in the workup of testicular tissue specimens from patients presenting with non-obstructive azoospemia. Methods: hTR and hTERT mRNA expression were quantified in 38 cryopreserved testicular tissue specimens by fluorescence real-time reverse transcription- polymerase chain reaction (RT-PCR)in a LightCycler(r). This was paralleled by conventional histological workup in all tissue specimens and additional semithin sectioning preparation in cases with maturation arrest ( n = 12) and Sertoli-cell-only syndrome ( n = 12). Results: The average normalized hTERT expression (NhTERT) Was 131.9 ± 48.0 copies (mean ± SD) in tissue specimens with full spermatogenesis, NhTERT = 51.2 ± 17.2 copies in those with maturation arrest and NhTERT = 2.7 ± 2.4 copies in those with Sertoli-cell-only syndrome (SCOS). The discriminant analysis showed that detection of NhTERT (NhTR) had a predictive value of 86.8 % (55.3 % ) for correct classification in one of the three histological subgroups.Conclusion: Our results demonstrate that quantitative detection of hTERT mRNA expression in testicular tissue enables a molecular-diagnostic classification of gametogenesis. Quantitative detection of hTERT in testicular biopsies is thus well suited for supplementing the histopathological evaluation.

  16. 探讨多囊卵巢综合征不孕患者治疗方式%To Investigate the Treatment of Infertility in Patients With Polycystic Ovary Syndrome

    Institute of Scientific and Technical Information of China (English)

    张春许

    2015-01-01

    Objective Explore effective methods for treating infertility polycystic ovary syndrome. Methods 54 cases of polycystic ovary syndrome infertility patients were selected from January 2012 to December 2013 in our hospital, all patients were given medicine treatment of artificial cycle. Results This group of patients were treated with 37 cases, effective in 11 cases, invalid in 6 cases, effective rate was 88.9%, the curative effect was satisfactory. Conclusion Artificial periodic therapy for polycystic ovary syndrome infertility, can adjust the menstrual cycle, improve clinical symptoms, improve pregnancy rate, the exact effect.%目的:探讨有效的治疗多囊卵巢综合征不孕的方法。方法选择我院2012年1月~2013年12月收治的54例多囊卵巢综合征不孕患者的临床资料,全部患者均给予中药人工周期法治疗。结果本组患者经治疗37例,有效11例,无效6例,有效率88.9%,疗效较为满意。结论采用中医人工周期疗法治疗多囊卵巢综合征不孕,可调整月经周期,改善临床症状,提高妊娠率,疗效确切。

  17. Research on Correlation between Alexithymia and Quality of Life in Infertile Patients%不孕不育患者述情障碍与其生活质量相关性研究

    Institute of Scientific and Technical Information of China (English)

    王玲

    2014-01-01

    Alexithymia is a kind of cognitive emotional disorders affecting the individual emotional experience and presentation ,often leads to inappropriate behavior and affects the effect of psychological and physical therapy .Infertility is a disease involving personal privacy ,family and social problems .This research showed that there was a higher degree of alexithymia in infertility patients ,mainly manifested in the lack of the emotional ability ,often expressing their emotions in the form of a physical disorders ,such as anxiety and depression .It indicated that we should use appropriate means of communication to accurately grasp the patients ’ conditions and inner feelings when treating patients with infertility , supplemented by appropriate psychological treatment in order to improve treatment effect .%述情障碍是影响个人情绪体验和表达方式的一种认知情感障碍,常导致患者不恰当的疾病行为并影响心理、躯体治疗效果。不孕不育是一个涉及个人隐私、家庭及社会问题的疾病,研究显示不孕不育患者存在较高程度的述情障碍,主要表现在缺乏描述情感的能力,易于用躯体障碍的形式来表现其焦虑、抑郁等情绪。从研究结论可知,在对不孕不育患者进行治疗时,应采用恰当的沟通方式,准确把握其病情及内心感受,并辅以恰当心理治疗,以提高治疗效果。

  18. Systematic characterization of seminal plasma piRNAs as molecular biomarkers for male infertility

    Science.gov (United States)

    Hong, Yeting; Wang, Cheng; Fu, Zheng; Liang, Hongwei; Zhang, Suyang; Lu, Meiling; Sun, Wu; Ye, Chao; Zhang, Chen-Yu; Zen, Ke; Shi, Liang; Zhang, Chunni; Chen, Xi

    2016-01-01

    Although piwi-interacting RNAs (piRNAs) play pivotal roles in spermatogenesis, little is known about piRNAs in the seminal plasma of infertile males. In this study, we systematically investigated the profiles of seminal plasma piRNAs in infertile males to identify piRNAs that are altered during infertility and evaluate their diagnostic value. Seminal plasma samples were obtained from 211 infertile patients (asthenozoospermia and azoospermia) and 91 fertile controls. High-throughput sequencing technology was employed to screen piRNA profiles in seminal plasma samples pooled from healthy controls and infertile patients. The results identified 61 markedly altered piRNAs in infertile patient groups compared with control group. Next, a quantitative RT-PCR assay was conducted in the training and validation sets to measure and confirm the concentrations of altered piRNAs. The results identified a panel of 5 piRNAs that were significantly decreased in seminal plasma of infertile patients compared with healthy controls. ROC curve analysis and risk score analysis revealed that the diagnostic potential of these 5 piRNAs to distinguish asthenozoospermic and azoospermic individuals from healthy controls was high. In summary, this study identifies a panel of piRNAs that can accurately distinguish fertile from infertile males. This finding may provide pathophysiological clues about the development of infertility. PMID:27068805

  19. Laparohysteroscopy in female infertility: A diagnostic cum therapeutic tool in Indian setting

    OpenAIRE

    Puri, Suman; Jain, Dinesh; Puri, Sandeep; Kaushal, Sandeep; Deol, Satjeet Kaur

    2015-01-01

    Aims: To evaluate the role of laparohysteroscopy in female infertility andto study the effect of therapeutic procedures in achieving fertility. Settings and Design: Patients with female infertility presenting to outpatient Department of Obstetrics and Gynecology were evaluated over a period of 18 months. Materials and Methods: Fifty consenting subjects excluding male factor infertility with normal hormonal profile and no contraindication to laparoscopy were subject to diagnostic laparoscopy a...

  20. Local Signaling Environments and Human Male Infertility: What Can Be Learned from Mouse Models

    OpenAIRE

    2010-01-01

    Infertility is one of the most prevalent public health problems facing young adult males in today’s society. A clear, treatable cause of infertility cannot be determined in a large number of these patients, and a growing body of evidence suggests that infertility in many of these men may be due to genetic causes. Studies utilizing animal models, and most importantly, mouse knockout technology, have been integral not only for the study of normal spermatogenesis but also for identifying protein...

  1. Serum Levels of Melatonin and Oxidative Stress Markers and Correlation between Them in Infertile Men

    OpenAIRE

    Sara Soleimani Rad; Shamsi Abbasalizadeh; Amir Ghorbani Haghjo

    2013-01-01

    Introduction: Infertility is the problem of 15% of young couples in different societies. One of the factors that could affect fertility is oxidative stress. Therefore, the aim of the present study is to investigate the level of Melatonin, a free radical scavenger, and its correlation with oxidative biomarkers in infertile men. Methods:For this purpose, fertile and infertile men in 2 groups, 30 people in each group, were studied. The fertile men were selected from husbands of patients admitted...

  2. Infertility in Women: Hysterosalpingographic Assessment of the Fallopian Tubes in Lagos, Nigeria

    Science.gov (United States)

    Akinola, R. A.; Akinola, O. I.; Fabamwo, A. O.

    2009-01-01

    Tubal disease constitutes a major factor in infertility especially in developing countries. This study was undertaken to assess the hysterosalpingographic patterns seen in infertile patients in an urban centre in Lagos. Two hundred and twenty patients who reported from the gynaecology clinic to the radiology department of Lagos State University…

  3. Infertility in Women: Hysterosalpingographic Assessment of the Fallopian Tubes in Lagos, Nigeria

    Science.gov (United States)

    Akinola, R. A.; Akinola, O. I.; Fabamwo, A. O.

    2009-01-01

    Tubal disease constitutes a major factor in infertility especially in developing countries. This study was undertaken to assess the hysterosalpingographic patterns seen in infertile patients in an urban centre in Lagos. Two hundred and twenty patients who reported from the gynaecology clinic to the radiology department of Lagos State University…

  4. 'Mama and papa nothing': living with infertility among an urban population in Kigali, Rwanda.

    Science.gov (United States)

    Dhont, N; van de Wijgert, J; Coene, G; Gasarabwe, A; Temmerman, M

    2011-03-01

    Not being able to procreate has severe social and economic repercussions in resource-poor countries. The purpose of this research was to explore the consequences of female and/or male factor infertility for men and women in Rwanda. Both quantitative and qualitative methods were used. Couples presenting with female and/or male factor infertility problems at the infertility clinic of the Kigali University Teaching Hospital (n = 312), and fertile controls who recently delivered (n = 312), were surveyed about domestic violence, current and past relationships and sexual functioning. In addition, five focus group discussions were held with a subsample of survey participants, who were either patients diagnosed with female- or male-factor fertility or their partners. Domestic violence, union dissolutions and sexual dysfunction were reported more frequently in the survey by infertile than fertile couples. The psycho-social consequences suffered by infertile couples in Rwanda are severe and similar to those reported in other resource-poor countries. Although women carry the largest burden of suffering, the negative repercussions of infertility for men, especially at the level of the community, are considerable. Whether the infertility was caused by a female factor or male factor was an important determinant for the type of psycho-social consequences suffered. In Rwanda, as in other resource-poor countries, infertility causes severe suffering. There is an urgent need to recognize infertility as a serious reproductive health problem and to put infertility care on the public health agenda.

  5. Application of Beck self-rating depression scale among patients with infertility%Beck抑郁自评问卷在不孕症患者中的应用

    Institute of Scientific and Technical Information of China (English)

    谭丽; 张婷婷; 王姿雅; 徐博文

    2011-01-01

    Objective: To research the reliability and validity of Beck self- rating depression scale among patients with infertility,provide a basis for choosing depression self - assessment tool for patients with infertility.Methods: Beck self - rating depression scale was used to investigate 176 patients with infertihty, factor analysis was used to research the reliability and validity of Beck self - rating depression scale.Results: Beck self- rating depression scale chose four factors including pessimism, depression, diminished capacity and low self- evaluation; the Cronbach α coefficients of four dimensions were 0.583, 0.554, 0.398 and 0.529, respectively; the total Cronbach α coefficient was 0.718; the correlation coefficient between dimensions and total score of the questionnaire was 0.43 ~ 0.809 ( P < 0.01 ).Conclusion: The reliability and validity of Beck self - rating depression scale are good, Beck self - rating depression scale can reflect the depression status of infertile cases effectively; the depression status of infertile cases is high, necessary preventive measures should be adopted to intervene the adverse psychological state early.%目的:研究Beck抑郁自评问卷在不孕症患者中使用的信度和效度,为不孕症患者抑郁状态自评工具的选择提供依据.方法:应用Beck抑郁白评问卷(BDI),对176例不孕症患者进行调查,采用因素分析方法研究BDI的信度和效度.结果:BDI提取了悲观情绪、抑郁情绪、能力减退、自我评价低4个因子;该问卷Cronbach α系数4个构面分别是0.583,0.554、0.398、0.529,总Cronbach α系数为0.718;各分维度与问卷总分的相关在0.43~0.809之间(P<0.01).结论:Beck抑郁自评问卷具有较好的信度和效度,可以有效反映不孕症患者的抑郁状态.不孕症患者抑郁状态较高,应采取必要的预防措施对其不良心理状态进行早期干预.

  6. Infertility in men with inflammatory bowel disease

    Institute of Scientific and Technical Information of China (English)

    Takeshi Shin; Hiroshi Okada

    2016-01-01

    Inflammatory bowel disease(IBD) predominantly affects young adults. Fertility-related issues are therefore im-portant in the m-anagem-ent of patients with IBD. However, relatively m-odest attention has been paid to reproductive issues faced by m-en with IBD. To investigate the effects of IBD and its treatm-ent on m-ale fertility, we reviewed the current literature using a system-atic search for published studies. A PubM ed search were perform-ed using the m-ain search term-s "IBD AND m-ale infertility", "Crohn’s disease AND m-ale infertility", "ulcerative colitis AND m-ale infertility". References in review articles were used if relevant. We noted that active inflammation, poor nutrition, alcohol use, sm-oking, m-edications, and surgery m-ay cause infertility in m-en with IBD. In surgery such as proctocolectom-y with ileal pouch-anal anastom-osis, rectal incision seem-s to be associated with sexual dysfunction. Of the m-edications used for IBD, sulfasalazine reversibly reduces m-ale fertility. No other m-edications appear to affect m-ale fertility significantly, although sm-all studies suggested som-e adverse effects. There are lim-ited data on the effects of drugs for IBD on m-ale fertility and pregnancy outcom-es; however, patients should be inform-ed of the possible effects of paternal drug exposure. This review provides inform-ation on fertility-related issues in m-en with IBD and discusses treatm-ent options.

  7. Effects of Nursing Care Based on Watson’s Theory of Human Caring on Anxiety, Distress, And Coping, When Infertility Treatment Fails: A Randomized Controlled Trial

    National Research Council Canada - National Science Library

    Yeter Durgun Ozan; Hülya Okumuş

    2017-01-01

    ...: Watson's theory of human caring is recommended as a guide to nursing patients with infertility treatment to decrease levels of anxiety and distress, and to increase the positive coping style among infertile women...

  8. Infertility and assisted reproduction in Denmark. Epidemiology and psychosocial consequences.

    Science.gov (United States)

    Schmidt, Lone

    2006-11-01

    treatment are interwoven with each others in a complex pattern, a pattern that both differed and was similar when comparing women and men. The infertility-related communication strategy (secrecy, formal, open-minded)identified in the qualitative interviews was later confirmed in the COMPI Infertility Cohort. Using the formal strategy and not talking about the emotional aspects of infertility and its treatment suggested high fertility problem stress. The coping strategies studied showed significant social differences and active-avoidance coping was a significant predictor of high fertility problem stress. A positive effect of infertility on the marriage, marital benefit was common. Men using the secrecy communication strategy had increased risk of low marital benefit. Difficult partner communication was a significant predictor of high fertility problem stress and among men, of low marital benefit. The intervention study showed that it was possible for the participants to change their communication with partner and other people close to them and that participants achieved an increased awareness of what, how much and when to discuss with others. High fertility problem stress and high marital benefit were associated with high importance ratings of patient-centred care and intentions to use professional psychosocial services. Among women, high fertility problem stress was a predictor of lower satisfaction ratings with fertility treatment. High marital benefit was a predictor of high satisfaction ratings of both medical and patient-centred care. In conclusion, infertility is a common experience among couples attempting to become parents. Assisted reproduction in the public health-care system in Denmark has high success rates, i.e. pregnancies,deliveries and high patient satisfaction. A large minority of people in fertility treatment experience high fertility problem stress,and some use communication and coping strategies that predicts high stress. Developing and evaluating

  9. Preliminary investigation and analysis of demand for ethics education in patients with infertility%不孕症患者伦理教育需求的初步调查与分析

    Institute of Scientific and Technical Information of China (English)

    郭靖; 王玲; 陈佩; 赵晓明; 袁蕙芸

    2012-01-01

    Objective To identify the medical demand of patients with infertility and the content and implementation method of ethics education. Methods A total of 150 patients with infertility were randomly selected, and the questionnaire survey of demand for ethics education was conducted. The questionnaire was designed on the basis of expert consultation, which included the demand for medical service and difficulty in asking for medical help, current situation of ethics education, awareness of patients on treatment, content and effect of ethics education and ways of ethics education. The recovery rate of questionnaire was 100% . Results Patients with infertility needed medical advice urgently, but the current situation of ethics education provided by medical institutions was not optimistic. Patients were not completely aware of the treatment course and legal consequence, and were not clear of the content of ethics education. Besides, the degree of acceptance for the mode of ethics education also needed to be improved. Conclusion Ethics education for patients with infertility is necessary and feasible, in which strengthening informed consent principle is the key problem to perfect the current ethics education. Medical institutions should design the content and process of ethics education standardly, and implement the ethics education though different ways, so that patients with infertility can get a variety of information.%目的 明确不孕症患者的就诊需求和伦理教育的内容与实施方法.方法 采取随机抽样法,选取150例不孕症患者进行伦理教育需求的问卷调查.在专家访谈的基础上自拟调查问卷,内容主要包括不孕症患者的就诊需求和困难、伦理教育的现状、患者对治疗的知情同意情况、伦理教育的内容和效果以及伦理教育途径5个方面.问卷有效回收率为100%.结果 不孕症患者就医愿望迫切,而医疗机构对患者健康与伦理教育的现状并不乐观,患者对

  10. Influencing factors analysis of the postoperative pregnancy in patients with endometriosis-associated infertility%子宫内膜异位症合并不孕患者术后妊娠影响因素分析

    Institute of Scientific and Technical Information of China (English)

    郭晶; 郝敏; 王永红; 王伟

    2013-01-01

    Objective To investigate the influencing factors of the postoperative pregnancy in patients with endometriosisassociated infertility.Methods 66 patients with endometriosis-associated infertility who underwent laparoscopic treatment in our hospital were followed up to assess fertility outcome.The clinical data was analyzed retrospectively.Results The overall postoperative pregnancy rate within 36 months was 56.1%.The postoperative pregnancy rate was 40.9%,13.6% and 1.5% in the first,the second and the third year respectively.There were significant differences among the three groups(P < 0.05).The ovarian stimulation treatment is protective factor of postoperative pregnancy (OR =0.191,P <0.05),and age,type of infertility,infertility time are risk factors (OR =6.281,5.427,7.890,P < 0.05).However,the postoperative pregnancy rate had no correlation with GnRHa treatment,r-AFS staging,EMT categories (P > 0.05).Conclusion Age,type of infertility,infertility time,ovarian stimulation treatment are proved to be very valuable in predicting the fertility outcome.%目的 探讨子宫内膜异位症(内异症)合并不孕患者腹腔镜术后妊娠的影响因素.方法 回顾性分析2007年1月至2011年12月在山西医科大学第二医院进行腹腔镜手术治疗的内异症合并不孕、随访资料完整的66例患者的临床资料,随访术后妊娠相关因素.结果 66例患者术后3年累积妊娠率为56.1%;术后第1、2、3年的妊娠率分别为40.9%、13.6%和1.5%,组间比较差异有统计学意义(P<0.05).使用促排卵治疗是术后妊娠的保护因素(OR =0.191,P<0.05),而年龄、不孕类型、不孕时间为危险因素(OR =6.281、5.427、7.890,P<0.05);是否使用促性腺激素释放激素激动剂(GnRHa)、不同r-AFS分期及不同临床病理类型术后妊娠率比较差异无统计学意义(P>0.05).结论 患者年龄、不孕时间、不孕类型、是否使用促排卵药物是影响内异症合并不

  11. Predictive value of hormonal parameters for live birth in women with unexplained infertility and male infertility

    National Research Council Canada - National Science Library

    Murto, Tiina; Bjuresten, Kerstin; Landgren, Britt-Marie; Stavreus-Evers, Anneli

    2013-01-01

    ... for long-term possibility of live birth. In this cross-sectional study, with 71 infertile women with diagnosis unexplained infertility and male infertility, blood samples were obtained during the proliferative and secretory phases...

  12. Incidence investigation and its effect on fertility of male infertility patients with chronic prostatitis%男性不育患者慢性前列腺炎的发病调查及其对生育的影响

    Institute of Scientific and Technical Information of China (English)

    张磊; 夏亭; 刘啸

    2015-01-01

    Objective:To explore the incidence condition and its adverse effect on fertility of male infertility patients with chronic prostatitis(CP).Methods:262 patients with male infertility were selected.The prostate disease historys were given inquiry and examination diagnosis.The adverse effect of CP on fertility of patients was analyzed.Results:102 patients were diagnosed with CP, and the incidence rate of CP was 38.93%.22 cases(8.40%) were Ⅱ,ⅢA type prostatitis,14 cases(5.34%) were ⅢB type,66 cases(25.19%) were Ⅳ type.The incidence rate of seminal fluid not liquefaction of CP patients was significantly higher than that of patients without CP(P<0.05).Conclusion:In patients with male infertility,the incidence of CP is relatively common.It easily leads to patients with seminal fluid not liquefaction problem(effect on fertility).%目的:探究男性不育患者慢性前列腺炎(CP)的发病状况及其对生育的不利影响。方法:收治男性不育患者262例,对前列腺疾病史进行询问及检查诊断,分析CP对患者生育的不利影响。结果:诊断明确患有CP的患者102例,CP发生率38.93%,其中Ⅱ、ⅢA型前列腺炎22例(8.40%),ⅢB型14例(5.34%),Ⅳ型66例(25.19%)。CP患者的精液不液化发生率明显高于未患CP患者(P<0.05)。结论:在男性不育患者中,CP的发生较为常见,极易导致患者出现精液不液化的问题(影响生育)。

  13. Focus Issue on Male Infertility

    Directory of Open Access Journals (Sweden)

    Hideyuki Kobayashi

    2012-01-01

    Full Text Available Male infertility problems can occur when sperms are limited in number or function. In this paper, we describe the clinical evaluation of male infertility. A detailed history, physical examination, and basic semen analysis are required. In addition, ultrasound, karyotyping, and hormonal studies are needed to determine specific causes of infertility. In addition, the World Health Organization (WHO, 2009 has developed a manual to provide guidance in performing a comprehensive semen analysis. Among the possible reasons for male infertility, nonobstructive azoospermia is the least treatable, because few or no mature sperm may be produced. In many cases, men with nonobstructive azoospermia typically have small-volume testes and elevated FSH. Although treatment may not completely restore the quality of semen from men with subnormal fertility, in some cases a successful pregnancy can still be achieved through assisted reproductive technology.

  14. Pregnancy rate following bromocriptine treatment in infertile women with galactorrhea.

    Science.gov (United States)

    Eftekhari, Nahid; Mohammadalizadeh, Sakineh

    2009-02-01

    Infertility is one of the most common causes of women refer to gynecology clinics. Galactorrhea is defined as one of the causes of infertility caused by luteal phase defect and anovulatory cycles. The study aim was to investigate the effect of bromocriptine on pregnancy rate in infertile women with galactorrhea with or without high prolactin level. In a prospective study, consecutive women with infertility and galactorrhea who referred to Afzalipour Hospital and a private clinic during 5 years from May 2001 to May 2006 were included. The study was conducted on 205 infertile women (18-39 years) with galactorrhea. They were treated with 2.5 mg bromocriptine BID for up to 6 months. The mean duration of sterility was 43.1 +/- 37.1 months (range, 12-16). 76.1% of patients showed positive signs for pregnancy. The pregnancy rate was 81.7% in the patients with high prolactin level (>20 ng/dl) and 74.3% in the patients with normal prolactin level (P = 0.26). There was a significant difference between mean duration of treatment with bromocriptine in women with and without pregnancy, 103.71 and 193.03 days, respectively (P galactorrhea, we suggest treatment with bromocriptine in these patients regardless of serum prolactin level.

  15. Impact of asymptomatic urogenital tract infections on ejaculate parameters in infertile men with varicocele

    Directory of Open Access Journals (Sweden)

    L. F. Kurilo

    2016-01-01

    Full Text Available Varicocele, a pathology developing in 15 % males, is associated with 30 % male infertility cases. The role of urogenital infections coinciding with varicocele in infertile men has not been studied in sufficient detail.Objective: to examine the effects of bacterial and viral infections on ejaculate parameters in infertile patients with varicocele. The study included 49 patients with infertility and varicocele and 26 healthy males undergoing prophylactic medical examination. Highlevel infection was recorded after examination of ejaculates and urethral scrapes of 49 patients: bacterial (30.6 % and viral (14.3 % pathogens. Quantitative analysis of viral DNA showed high contamination of ejaculates with herpes viruses (> 3 lg10/ml. Detailed analysis of spermatograms demonstrated a decrease in all basic parameters in patients with varicocele and infertility compared with those in healthy subjects. The presence of infectious agents had a statistically significant negative effect on ejaculate parameters. Spermiological examination revealed high level of sperm abnormalities (astenozoospermia, oligoteratozoospermia, and oligoastenoteratozoospermia in patients with infertility, varicocele and bacterioviral infection of urogenital tract compared with uninfected infertile patients with varicocele. Laboratory tests for bacterial and viral infections should be recommended in infertility associated with varicocele even in the absence of clinical signs of these infections. Quantitative analysis of urogenital pathogens allows one to determine the necessity of etiotherapy of hidden infection and to monitor the effectiveness of treatment.

  16. Infertility Counseling and Support: When and Where to Find It

    Science.gov (United States)

    ... Home FAQs Frequently Asked Questions Quick Facts About Infertility FAQs About Infertility FAQs About the Psychological Component of Infertility FAQs About Cloning and Stem Cell Research SART's ...

  17. [The validation of the use of prostatilen and testilin for treating male infertility].

    Science.gov (United States)

    Boĭko, M I

    1995-01-01

    The paper substantiates the use in clinical setting of medicinal preparations obtaining from prostate and tests, in male infertility. Using male rats for an experimental model of infertility it was shown that prostatilene and testilin exert a stimulating effect on spermatogenesis and androgenic functions of the testis. Those agents appear to correct androgenic-estrogenic balance in the animal organism as a model of infertility. The experiment permitted a conclusion to be drawn to the effect that prostatilene and testilin are liable to be of clinical benefit when used to stimulate spermatogenesis in infertility and hypoandrogenization; besides, the rise in androgens may stimulate copulative function in patients with sexual problems.

  18. Chromosomal disorders and male infertility

    Institute of Scientific and Technical Information of China (English)

    Gary L Harton; Helen G Tempest

    2012-01-01

    infertility in humans is surprisingly common occurring in approximately 15% of the population wishing to start a family.Despite this,the molecular and genetic factors underlying the cause of infertility remain largely undiscovered.Nevertheless,more and more genetic factors associated with infertility are being identified.This review will focus on our current understanding of the chromosomal basis of male infertility specifically:chromosomal aneuploidy,structural and numerical karyotype abnormalities and Y chromosomal microdeletions.Chromosomal aneuploidy is the leading cause of pregnancy loss and developmental disabilities in humans.Aneuploidy is predominantly maternal in origin,but concerns have been raised regarding the safety of intracytoplasmic sperm injection as infertile men have significantly higher levels of sperm aneuploidy compared to their fertile counterparts.Males with numerical or structural karyotype abnormalities are also at an increased risk of producing aneuploid sperm.Our current understanding of how sperm aneuploidy translates to embryo aneuploidy will be reviewed,as well as the application of preimplantation genetic diagnosis (PGD) in such cases.Clinical recommendations where possible will be made,as well as discussion of the use of emerging array technology in PGD and its potential applications in male infertility.

  19. Chromosomal disorders and male infertility.

    Science.gov (United States)

    Harton, Gary L; Tempest, Helen G

    2012-01-01

    Infertility in humans is surprisingly common occurring in approximately 15% of the population wishing to start a family. Despite this, the molecular and genetic factors underlying the cause of infertility remain largely undiscovered. Nevertheless, more and more genetic factors associated with infertility are being identified. This review will focus on our current understanding of the chromosomal basis of male infertility specifically: chromosomal aneuploidy, structural and numerical karyotype abnormalities and Y chromosomal microdeletions. Chromosomal aneuploidy is the leading cause of pregnancy loss and developmental disabilities in humans. Aneuploidy is predominantly maternal in origin, but concerns have been raised regarding the safety of intracytoplasmic sperm injection as infertile men have significantly higher levels of sperm aneuploidy compared to their fertile counterparts. Males with numerical or structural karyotype abnormalities are also at an increased risk of producing aneuploid sperm. Our current understanding of how sperm aneuploidy translates to embryo aneuploidy will be reviewed, as well as the application of preimplantation genetic diagnosis (PGD) in such cases. Clinical recommendations where possible will be made, as well as discussion of the use of emerging array technology in PGD and its potential applications in male infertility.

  20. Diagnostic Office Vaginohysteroscopy in Evaluation of Infertility Prior to IVF: A Retrospective Analysis of 1000 Cases.

    Science.gov (United States)

    Kumar, Praveen; Mohan, Surender; Talwar, Pankaj; Rai, Seema; Nagaraja, N; Sharma, Prashant

    2017-08-01

    The aim of this study was to analyze the utility of routine use of diagnostic office vaginohysteroscopy in the evaluation of uterine cavity in infertility patients prior to IVF-ET. We conducted a retrospective analysis of 1000 women who had undergone routine diagnostic office vaginohysteroscopy as an institutional protocol in the evaluation of infertility prior to IVF-ET cycle at a tertiary care hospital. They were divided into two groups: primary infertility (group I) and secondary infertility (group II). The primary outcome was the finding of an abnormal uterine cavity (congenital abnormality vs acquired abnormality). One thousand women underwent routine diagnostic office vaginohysteroscopy in the evaluation of infertility prior to IVF-ET. There were no intraoperative or postoperative complications. Vaginohysteroscopy revealed an abnormal uterine cavity in 13.8% (1000 patients) of women. Primary infertility group (I) had 13.19% (811 patients), and secondary infertility group (II) had 16.4% (189 patients) abnormal uterine cavities. Diagnostic office vaginohysteroscopy has a definite role in the uterine cavity evaluation in infertility patients prior to IVF, but routine use should not be recommended considering the low incidence of abnormal uterine cavity findings. Moreover, the majority of these uterine cavity abnormalities can be detected by less invasive tests such as HSG, TVS, SSG and 3D ultrasound.

  1. Chromosomal analysis in peripheral blood of 739 infertile patients with adverse pregnancy history%739例有不良孕产史及不育不孕患者外周血染色体分析

    Institute of Scientific and Technical Information of China (English)

    何娟

    2011-01-01

    Objective:To explore the relationship between abnormal chromosomal karyotype in peripheral blood and adverse pregnancy history, infertility. Methods;739 infertile patients with adverse pregnancy history received culture and preparation section of lymphocytes in peripheral blood and C -binding chromosome karyotyping. Results:21 patients were found with chromosomal polymorphism, 8 patients were found with balanced translocation (including 1 patient with Robertsonian translocation) , 1 patient was found with pericentric inversion of chromosome 21,5 patients were found with chimera, the proportion of abnormal karyotypes was 4. 74%. Conclusion: Unexplained spontaneous abortion, stillbirth, teratism are related to chromosomal abnormality. The carriers of abnormal chromosome without phenotype can transmit it to their infants, induce infertility and adverse pregnant phenomena, such as abortion, stillbirth and teratism. Genetic counseling should be provided to the carriers, and prenatal diagnosis should be carried out among the pregnant women, which play important roles in a-voiding the birth of infants with chromosomal diseases, reducing birth defect and improving the quality of birth population in the region.%目的:探讨外周血异常染色体核型与不良孕产史、不育不孕的关系.方法:对739例有不良孕产史及不育不孕夫妇的外周血淋巴细胞进行培养、制片及G显带染色体核型分析.结果:检出染色体多态性21例,平衡易位8例(其中1例为罗伯逊易位),21号染色体臂间倒位1例,嵌合体5例,异常核型约占4.74%.结论:不明原因的流产、死胎、畸胎与染色体异常有关.无表型的异常染色体携带者可将异常染色体核型传给子代,不仅可引起不孕不育,还可以引起流产、死胎、畸胎等不良孕产现象.对检出携带者应为其提供遗传咨询,对妊娠成功者进行产前诊断,避免染色体病患儿的出生,减少出生缺陷,对提高本地区人口素质具有重要意义.

  2. Chlamydia trachomatis urogenital infection in women with infertility.

    Science.gov (United States)

    Wilkowska-Trojniel, M; Zdrodowska-Stefanow, B; Ostaszewska-Puchalska, I; Zbucka, M; Wołczyński, S; Grygoruk, C; Kuczyński, W; Zdrodowski, M

    2009-01-01

    The study objective was to evaluate the prevalence of urogenital Chlamydia trachomatis (C.tr.) infection in women with diagnosed infertility. The study involved patients from the Department of Gynecological Endocrinology and from the Center for Reproductive Medicine "Kriobank" in Bialystok. Female patients (n=71), aged 23-41, were divided into two groups according to the main diagnosis: A--tubal infertility (23) and B--infertility of another origin (48). For direct testing, PCR method was used to detect C.tr. infection in cervical samples (Roche, Molecular Systems, N.J., USA). Specific IgA and IgG anti-chlamydial antibodies in the serum were determined by immunoenzymatic assay (medac, Hamburg, Germany). Diagnostic procedures were performed at the Centre for STD Research and Diagnostics in Bialystok. In group A, C.tr. infection was detected in: 8.7% patients, in group B--8.3%. Specific anti-C.tr. antibodies IgA were detected in: 13.0% in group A and 6.3% in group B, IgG respectively in 39.1% and in 10.4%. 1. C.tr. infection is very important etiological factor of female infertility. 2. The detection of specific antichlamydial antibodies is a valuable, noninvasive diagnostic procedure. 3. Infertile women should be routinely tested for C.tr. infection.

  3. The role of Tadalafil in treatment of infertility

    Institute of Scientific and Technical Information of China (English)

    Giorgio Cavallini; Giulio Biagiotti

    2012-01-01

    Objective: It was the aim of this research to assess whether Tadalafil 5 mg once daily can improves the sperm count of unexplained infertile males with erectile deficiency induced by the emotional stress of attempting to father children. Methods: Two groups, each made up of 30 unexplained infertile males with psychogenic erectile deficiency related to attempts to father children received Tadalafil 5 mg once daily (Group 1) or a placebo (Group 2) for one month. Unexplained infertile men are intended as normospermic men who could not father children over a one year period and whose female partner is free of factors causing infertility. The endpoints were:differences between the groups in restoring erectile response, modifying sperm count, side effects and modifications of sperm analyses with respect to resolution or not of the erectile deficiency irrespective of the substance (Tadalafil or placebo) used. The means were compared using analysis of variance and the percentages using the chi square test. Results:The patients who received Tadalafil had their sperm volume, concentration and motility increased, but not the percentage of typical forms. Patients who received a placebo had no significant improvement. Additional analyses indicated that sperm volume, concentration and motility (but not morphology) significantly increased only in the patients who restored erectile response to sexual stimulation, independently of Tadalafil or placebo administration. No significant side effects were present. Conclusions: It is thought that therapies aimed at removing emotional stress linked to the performance anxiety of fathering children might improve sperm count in unexplained infertile couples.

  4. [Orchitis and male infertility].

    Science.gov (United States)

    Schuppe, H-C; Pilatz, A; Hossain, H; Meinhardt, A; Bergmann, M; Haidl, G; Weidner, W

    2010-05-01

    Infections and inflammations of the genital tract are considered the most frequent causes of reduced male fertility, but conclusive epidemiological data are not available. In view of the exposure of germ cells to pathogenic components as well as the cells and mediators involved in the inflammatory processes, irreversible damage to spermatogenesis and corresponding decline of ejaculate quality are to be expected, particularly in cases of chronic orchitis. While the consequences of orchitis and epididymo-orchitis that exhibit clinical symptoms due to systemic or local infections are well known, including testicular atrophy and complete loss of fertility, those cases of inflammatory reactions of the testicles that manifest an asymptomatic or subclinical course, or are not even due to an infection, have received little attention until now. However, systematic histopathological analyses have shown a high prevalence of asymptomatic inflammatory reactions in testicular biopsies from infertile men. The mostly focal lymphocytic infiltrates correlate with the degree of damage to spermatogenesis and corresponding clinical and endocrinological parameters of testicular function. Noninvasive diagnostic techniques are not yet available so that chronic asymptomatic inflammations of the testicles as the primary cause or cofactor of male fertility disorders are underestimated. Except for administration of pathogen-specific antibiotics, treatment recommendations are to a large extent still lacking.

  5. Genetics of human male infertility.

    Science.gov (United States)

    Poongothai, J; Gopenath, T S; Manonayaki, S

    2009-04-01

    Infertility is defined as a failure to conceive in a couple trying to reproduce for a period of two years without conception. Approximately 15 percent of couples are infertile, and among these couples, male factor infertility accounts for approximately 50 percent of causes. Male infertility is a multifactorial syndrome encompassing a wide variety of disorders. In more than half of infertile men, the cause of their infertility is unknown (idiopathic) and could be congenital or acquired. Infertility in men can be diagnosed initially by semen analysis. Seminograms of infertile men may reveal many abnormal conditions, which include azoospermia, oligozoospermia, teratozoospermia, asthenozoospermia, necrospermia and pyospermia. The current estimate is that about 30 percent of men seeking help at the infertility clinic are found to have oligozoospermia or azoospermia of unknown aetiology. Therefore, there is a need to find the cause of infertility. The causes are known in less than half of these cases, out of which genetic or inherited disease and specific abnormalities in the Y chromosome are major factors. About 10-20 percent of males presenting without sperm in the ejaculate carry a deletion of the Y chromosome. This deleted region includes the Azoospermia Factor (AZF) locus, located in the Yq11, which is divided into four recurrently deleted non-overlapping subregions designated as AZFa, AZFb, AZFc and AZFd. Each of these regions may be associated with a particular testicular histology, and several candidate genes have been found within these regions. The Deleted in Azoospermia (DAZ) gene family is reported to be the most frequently deleted AZF candidate gene and is located in the AZFc region. Recently, a partial, novel Y chromosome 1.6-Mb deletion, designated "gr/gr" deletion, has been described specifically in infertile men with varying degrees of spermatogenic failure. The DAZ gene has an autosomal homologue, DAZL (DAZ-Like), on the short arm of the chromosome 3 (3

  6. Salpingitis isthmica nodosa in female infertility and tubal diseases

    DEFF Research Database (Denmark)

    Skibsted, L; Sperling, Lene; Hansen, U

    1991-01-01

    with infertility, pregnancies, outcome of pregnancies, births, pelvic inflammatory disease and salpingitis. Sections from the isthmus were present in the specimens from 223 tubes from 193 patients and were analysed by the same pathologist. Originally, SIN was found in 12 patients but on re...

  7. Coenzyme Q10 and male infertility.

    Science.gov (United States)

    Balercia, G; Mancini, A; Paggi, F; Tiano, L; Pontecorvi, A; Boscaro, M; Lenzi, A; Littarru, G P

    2009-07-01

    We had previously demonstrated that Coenzyme Q10 [(CoQ10) also commonly called ubiquinone] is present in well-measurable levels in human seminal fluid, where it probably exerts important metabolic and antioxidant functions; seminal CoQ10 concentrations show a direct correlation with seminal parameters (count and motility). Alterations of CoQ10 content were also shown in conditions associated with male infertility, such as asthenozoospermia and varicocele (VAR). The physiological role of this molecule was further clarified by inquiring into its variations in concentrations induced by different medical or surgical procedures used in male infertility treatment. We therefore evaluated CoQ10 concentration and distribution between seminal plasma and spermatozoa in VAR, before and after surgical treatment, and in infertile patients after recombinant human FSH therapy. The effect of CoQ10 on sperm motility and function had been addressed only through some in vitro experiments. In two distinct studies conducted by our group, 22 and 60 patients affected by idiopathic asthenozoospermia were enrolled, respectively. CoQ10 and its reduced form, ubiquinol, increased significantly both in seminal plasma and sperm cells after treatment, as well as spermatozoa motility. A weak linear dependence among the relative variations, at baseline and after treatment, of seminal plasma or intracellular CoQ10, ubiquinol levels and kinetic parameters was found in the treated group. Patients with lower baseline value of motility and CoQ10 levels had a statistically significant higher probability to be responders to the treatment. In conclusion, the exogenous administration of CoQ10 increases both ubiquinone and ubiquinol levels in semen and can be effective in improving sperm kinetic features in patients affected by idiopathic asthenozoospermia.

  8. Screening for chromosomal abnormalities in 2650 infertile couples undergoing ICSI.

    Science.gov (United States)

    Kayed, Hesham F; Mansour, Ragaa T; Aboulghar, Mohamed A; Serour, Gamal I; Amer, Alaa E; Abdrazik, Ashraf

    2006-03-01

    Chromosomal abnormalities are the major contributor to the genetic risks of infertility treatment associated with intracytoplasmic sperm injection (ICSI). The study objective was to assess prospectively the frequency of chromosomal aberrations in couples undergoing ICSI. A total of 2650 infertile couples (5300 patients) underwent chromosome analysis before undergoing ICSI in the Egyptian IVF-ET Centre. Heparinized blood samples were cultured, harvested and banded according to standard methods. Overall, 96.94% of the patients studied (5138/5300) had a normal karyotype, while the remaining 162 patients (3.06%) had an abnormal karyotype. Male patients constituted the majority of abnormalities; 138 males (85.19%) and 24 females (14.81%). These chromosomal aberrations included 117 cases (2.2%) of sex chromosome abnormalities; 113 males and four females. Forty-five patients (0.85%) had autosomal aberrations; 25 of them were males and 20 were females. The current data show that chromosomal abnormalities affect 3.06% of infertile patients, and occur in both sexes, but more predominantly in males undergoing ICSI for male factor infertility. It is recommended that chromosomal analysis be performed before undergoing ICSI, to identify patients who can be offered preimplantation genetic diagnosis.

  9. Clinical analysis on ovulation induction for infertile patients with polycystic ovary syndrome%多囊卵巢综合征不孕症患者的促排卵治疗临床分析

    Institute of Scientific and Technical Information of China (English)

    王彩虹

    2012-01-01

    目的:探讨应用盐酸二甲双胍配合促排卵药治疗多囊卵巢综合征(PCOS)引起不孕的临床效果.方法:选择该院不孕症门诊就诊的患者,分成PCOS组102例,调月经周期同时服盐酸二甲双胍2~3个月后,促排卵治疗;非PCOS组490例,对月经不调和有内分泌疾病的患者调月经周期同时治疗内分泌疾病2~3个月后,促排卵治疗.观察治疗后的妊娠率、卵巢过度刺激综合征(OHSS)发生率、多胎妊娠和早期流产发生情况.结果:PCOS组的妊娠率、OHSS发生率明显高于非PCOS组,P<0.01;多胎发生情况也高于非PCOS组,P<0.01;早期流产的发生无明显差异,P>0.05.结论:盐酸二甲双胍配合促排卵治疗多囊卵巢综合征引起不孕的临床效果较好,能明显提高妊娠率,OHSS发生率在15%~16%,且程度较轻,结局良好.但是PCOS不孕患者促排卵时OHSS的发生和多胎妊娠很难完全避免.%Objective: To explore the clinical efficacy of metformin hydrochloride combined with ovulation induction for treatment of infertility caused by polycystic ovary syndrome (PCOS) . Methods: The infertile patients from outpatient department of infertility of the hospital were selected and divided into PCOS group (102 cases) and non-PCOS group (490 cases) , the cases in PCOS group were treated with regulating menstrual cycle and oral administration of metformin hydrochloride for 2—3 months combined with ovulation induction; while the cases with abnormal menstruation and endocrine diseases in non — PCOS group were treated with regulating menstrual cycle and curing endocrine diseases for 2—3 months combined with ovulation induction. The pregnancy rates, the incidences of ovarian hyperstimulation syndrome (OHSS) , the rates of multiple pregnancy, and the incidences of early abortion after treatment in the two groups were observed. Results; The pregnancy rate, the incidence of OHSS, and the rate of multiple pregnancy in PCOS group were

  10. Clinical Analysis of Laparoscopic Surgery for Syndrome of 70 Infertility Patients with Polycystic Ovary Syndrome%腹腔镜治疗多囊卵巢综合征不孕患者70例临床分析

    Institute of Scientific and Technical Information of China (English)

    罗辑; 周燕

    2014-01-01

    Objective Laparoscopic treatment of polycystic ovarian syndrome caused by comprehensive pregnancy infertility patients clinical analysis. Methods In 2000 January to 2014 January in my hospital treated 70 cases of patients with polycystic ovary syndrome were selected, pregnancy rate and abortion rate in patients with laparoscopic treatment. Results After ovulation rate was 91.4%, pregnancy rate 73.3%. In 12 patients after 3 months not ovulation, 6 cases recovered to clomiphene citrate ovulation, menstruation is the operation had markedly. Conclusion Laparoscopic operation for the treatment of infertility caused by polycystic ovary syndrome is a rapid, ef ective method for the treatment of.%目的:对腹腔镜治疗多囊卵巢综合征所致不孕患者的妊娠情况进行临床分析。方法2000年1月~2014年1月对作者所在医院收治的70例多囊卵巢综合征患者,观察选用腹腔镜治疗后患者的妊娠率及流产率。结果术后排卵率为91.4%,妊娠率为73.3%。12例术后3个月内未排卵,予氯米芬6例恢复排卵,其余月经情况较手术前均有明显好转。结论腹腔镜手术用于治疗多囊卵巢综合征所致不孕是一种快捷、有效的治疗方法。

  11. Human parasitic protozoan infection to infertility: a systematic review.

    Science.gov (United States)

    Shiadeh, Malihe Nourollahpour; Niyyati, Maryam; Fallahi, Shirzad; Rostami, Ali

    2016-02-01

    Protozoan parasitic diseases are endemic in many countries worldwide, especially in developing countries, where infertility is a major burden. It has been reported that such infections may cause infertility through impairment in male and female reproductive systems. We searched Medline, PubMed, and Scopus databases and Google scholar to identify the potentially relevant studies on protozoan parasitic infections and their implications in human and animal model infertility. Literature described that some of the protozoan parasites such as Trichomonas vaginalis may cause deformities of the genital tract, cervical neoplasia, and tubal and atypical pelvic inflammations in women and also non-gonoccocal urethritis, asthenozoospermia, and teratozoospermia in men. Toxopalasma gondii could cause endometritis, impaired folliculogenesis, ovarian and uterine atrophy, adrenal hypertrophy, vasculitis, and cessation of estrus cycling in female and also decrease in semen quality, concentration, and motility in male. Trypanosoma cruzi inhibits cell division in embryos and impairs normal implantation and development of placenta. Decrease in gestation rate, infection of hormone-producing glands, parasite invasion of the placenta, and overproduction of inflammatory cytokines in the oviducts and uterine horns are other possible mechanisms induced by Trypanosoma cruzi to infertility. Plasmodium spp. and Trypanosoma brucei spp. cause damage in pituitary gland, hormonal disorders, and decreased semen quality. Entamoeba histolytica infection leads to pelvic pain, salpingitis, tubo-ovarian abscess, and genital ulcers. Cutaneous and visceral leishmaniasis can induce genital lesion, testicular amyloidosis, inflammation of epididymis, prostatitis, and sperm abnormality in human and animals. In addition, some epidemiological studies have reported that rates of protozoan infections in infertile patients are higher than healthy controls. The current review indicates that protozoan parasitic

  12. Novel concepts in male infertility

    Directory of Open Access Journals (Sweden)

    Sandro C. Esteves

    2011-02-01

    Full Text Available Extraordinary advances have been achieved in the field of male infertility in the last decades. There are new concepts in sperm physiology and several modern tools for the assessment of spermatogenesis kinetics in vivo. New tests using molecular biology and DNA damage assays allow the clinician to correctly diagnose men so far classified as having idiopathic male infertility. In the field of treatment, microsurgery has increased success rates either for reconstruction of the reproductive tract or the retrieval of spermatozoa for assisted conception. Emerging evidence suggests that life-style and environmental conditions are of utmost importance in male fertility and subfertility. This review discusses several concepts that have changed over the last years, such as the duration of the spermatogenic cycle in humans, Y-chromosome infertility, the reproductive potential of non-mosaic Klinefelter syndrome men, the impact of paternal age and sperm DNA in male infertility, the role of antioxidants in the treatment of infertile men, the predictive factors and techniques for sperm retrieval in non-obstructive azoospermia, and the microsurgical treatment of clinical varicoceles. Whenever possible, levels of evidence are provided as suggested by the Oxford Center of Evidence-based Medicine.

  13. Genetic aspects of male infertility

    Directory of Open Access Journals (Sweden)

    Bartosz Witczak

    2015-01-01

    Full Text Available Currently, infertility affects up to 140 million people worldwide. It is considered that the male factor is responsible for nearly a half of problems in obtaining pregnancy. Increasingly, infertility treatment clinics, as well as standard examinations, also offer genetic tests in the diagnostics of the male infertility factor, such as: karyotype analysis, detection of Y chromosome microdeletions, and examination of the chromosome composition of sperm by the fluorescent in situ hybridisation method (FISH. Genetic factors, defined to date, which cover both chromosomal aberrations and monogenic disorders, are responsible for approximately 10–15% of cases of male infertility. Usually, their phenotypic manifestations are disorders in spermatogenesis, structural changes in the genital organs (e.g. reduced size of the testicles, or sperm dysfunction. Molecular studies intensively carried out in the area of diagnostics and treatment of infertility indicate an increasingly large number of relationships between genetic factors and fertility; however, many genes related with human fertility still remain unidentified.

  14. Knowledge, attitude, and practices of infertility among Saudi couples

    Directory of Open Access Journals (Sweden)

    Abolfotouh MA

    2013-07-01

    Full Text Available Mostafa A Abolfotouh,1 Abdullah A Alabdrabalnabi,2 Rehab B Albacker,3 Umar A Al-Jughaiman,4 Samar N Hassan5 1King Abdullah International Medical Research Center (KAIMRC, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 2University of Dammam, College of Medicine, Dammam, Saudi Arabia; 3King Saud University, College of Medicine, Riyadh, Saudi Arabia; 4King Faisal University, College of Medicine, Dammam, Saudi Arabia; 5Division of Reproductive Medicine, Department of Obstetrics and Gynecology, King Abdulaziz Medical City, Riyadh, Saudi Arabia Introduction: Infertility places a huge psychological burden on infertile couples, especially for women. Greater knowledge of the factors affecting fertility may help to decrease the incidence of infertility by allowing couples to avoid certain risk factors. The aim of our study was (1 to assess the knowledge and attitudes of infertile and fertile Saudi participants on infertility, possible risk factors, and social consequences; and (2 to determine the practices of infertile Saudi couples to promote their fertility before having them attend an in vitro fertilization (IVF clinic. Methods and materials: We conducted a cross-sectional study on 277 fertile participants from outpatient clinics and 104 infertile patients from the IVF clinic at King Abdulaziz Medical City between June 24, 2012 and July 4, 2012, using a previously validated interview questionnaire. Descriptive and analytical statistics were applied with a significance threshold of P ≤ 0.05. Results: A generally poor level of knowledge (59% and a neutral attitude (76% toward infertility were reported by participants. Mistaken beliefs commonly held by the study participants regarding the causes of infertility were Djinns and supernatural causes (58.8%, black magic (67.5%, intrauterine devices (71.3%, and contraceptive pills (42.9%. The healer/Sheikh was reported as the primary and secondary preference for infertility

  15. 不同体质量指数男性不育患者心理评估%Psychological assessments in male infertility patients with dif-ferent body mass index

    Institute of Scientific and Technical Information of China (English)

    白双勇; 王剑松; 赵庆华

    2015-01-01

    Objective To explore mental health status of male infertility patients with different body mass index (BMI) in order to provide basis for clinical intervention .Methods Accord‐ing to BMI 292 male infertility patients were assigned to 3 groups :normal (n=84) ,overweight (n=114) and obesity group (n=91) .Assessments were conducted with the Symptom Checklist‐90 (SCL‐90) among 3 groups .Results The total ,obsession ,interpersonal relation ,depression and anxiety scores of the SCL‐90 were significantly higher in overweight and obesity group compared with norm (P<0 .05) ,so were the total and obsession compare with normal group (P<0 .05 or 0 .01);the total ,depression and anxiety score were significantly higher in normal group compared with norm (P<0 .05);the BMI was positively related to obsession ,depression and anxiety score notably (P<0 .05) .Conclusion Obesity and overweight male infertility patients have different degrees of psycho‐problems , to them purposeful mental interventions should be given .%目的:探讨不同体质量指数男性不育症患者的心理健康状况,为临床干预提供依据。方法将292例男性不育患者按照体质量指数分为3组,正常组84例,超重组117例,肥胖组91例。对3组患者应用症状自评量表进行测评分析。结果超重组和肥胖组症状自评量表总分及强迫、人际关系、抑郁、焦虑因子分均显著高于常模(P<0.05),总分及强迫因子分显著高于正常组(P<0.05或0.01);正常组总分及抑郁、焦虑因子分显著高于常模(P<0.05);入组被试体质量指数与强迫、抑郁、焦虑因子分呈显著正相关(P<0.05)。结论肥胖和超重男性不育患者存在不同程度的心理问题,应对其予以有针对性的心理干预。

  16. 多囊卵巢综合征不孕患者促排卵药物疗效对比%Efficacy comparison of ovulation induction on infertility patients with polycystic ovary syndrome

    Institute of Scientific and Technical Information of China (English)

    王惠清

    2016-01-01

    目的:比较多囊卵巢综合征不孕患者促排卵药物的疗效。方法随机选取2013年10月至2014年10月多囊卵巢综合征不孕患者80例,分为研究组(来曲唑组)与对照组(氯米芬组),每组40例。对比观察两组患者治疗后排卵与妊娠情况。结果研究组患者优势卵泡率为86.11%,对照组为59.21%;研究组患者排卵率为88.71%,对照组排卵率为64.44%;研究组患者妊娠率为40.00%,对照组妊娠率为20.00%;差异均有统计学意义(P <0.05)。结论相对于氯米芬,来曲唑应用于多囊卵巢综合征不孕患者,能更好的诱导优势卵泡生长发育,取得更佳的子宫内膜环境,提升妊娠率,值得临床推广应用。%Objective To compare the effect of ovulation induction on infertile patients with polycystic ovary syndrome. Methods From October 2013 to October 2014,80 infertile patients with polycystic ovary syndrome were divided into study group(letrozole group)and control group(clomiphene group),with 40 cases in each group. Ovulation and pregnancy was observed after treatment. Results The dominant follicle rate was 86. 11% in study group,and was 59. 21% in the control group;the ovula-tion rate in study group was 88. 71% ,and was 64. 44% in the control group;the pregnancy rate in study group was 40. 00% ,and was 20. 00% in the control group,the differences were significant(P < 0. 05). Conclusions Compared to clomiphene,letrozole in treatment of infertile patients with polycystic ovary syndrome,can better induce the dominant follicle growth,achieve better endometrial environment,im-prove the pregnancy rate,is worthy of clinical application.

  17. Treatments for Diseases That Cause Infertility

    Science.gov (United States)

    ... its symptoms is available from the NICHD PCOS topic page . Treatments for infertility in women with PCOS include ... this topic can be found on the NICHD topic page on endometriosis . Treatments for the infertility that can ...

  18. Subclinical Pelvic Inflammatory Disease and Infertility

    National Research Council Canada - National Science Library

    Wiesenfeld, Harold C; Hillier, Sharon L; Meyn, Leslie A; Amortegui, Antonio J; Sweet, Richard L

    2012-01-01

    OBJECTIVE:The reported incidence of acute pelvic inflammatory disease (PID) has decreased but rates of tubal infertility have not, suggesting that a large proportion of PID leading to infertility may be undetected...

  19. REVIEW ARTICLE: Infertility and Environment

    Directory of Open Access Journals (Sweden)

    Siddhartha Chatterjee

    2012-01-01

    Full Text Available Environment is coming up as one of the causative factors for many physical and mental diseases. Infertility is not only a medicalproblem; it is a social and psychological problem as well. Air and soil pollutions are disturbing the male and female reproductiveprocesses in various ways. Endocrine disruptors otherwise called Estrogen Mimics not only induce endometriosis, but can influence the reproductive process by competing with estrogen receptors. Insecticides and environmental toxicants also disrupt the reproductive process. Psychological stress is an important factor for infertility. This is also a stimulating factor for many gynecological conditions like Polycystic Ovary Syndrome (PCOS. In treating the infertile couples, psychological treatment & support areof equal importance as that of medical treatment.

  20. Women with polycystic ovary syndrome and treatment strategies of infertility patients%多囊卵巢综合征合并不孕患者治疗策略的研究

    Institute of Scientific and Technical Information of China (English)

    谭伟涛

    2013-01-01

    目的:探讨多囊卵巢综合征合并不孕患者治疗方法的选择及影响因素。方法选取2009年7月至2012年6月收治的多囊卵巢综合征合并不孕患者82例,分为研究组患者42例采用二甲双胍、炔雌醇环丙孕酮(达英-35)联合来曲唑治疗;对照组患者40例单纯采用来曲唑促排卵治疗。治疗时间为3~6个月,两组患者比较排卵率、妊娠率及妊娠后流产率。结果研究组患者正常排卵率为72.7%,对照组患者正常排卵率为62.3%(P >0.05),差异无统计学意义。研究组妊娠18例、流产2例;对照组妊娠8例、流产3例,两组比较差异具有统计学意义(P <0.05)。结论多囊卵巢综合征合并不孕症患者在接受促排卵治疗前先行二甲双胍、达英-35治疗可明显提高患者的妊娠率,降低流产率。对治疗患者不孕症疗效显著。%Objective The choice and influence factors combined infertility treatment of women with polycystic ovary syndrome. Methods From 2009 July to 2012 polycystic ovarian syndrome admitted from June 82 cases with infertility patients, divided into 42 cases of study group were treated with metformin, ethinylestradiol and cyproterone acetate (with 35) combined with letrozole therapy; the control group of 40 patients treated with letrozole induced ovulation treatment. The treatment time was 3 - 6 months, the abortion rate between two groups of ovulation rate, pregnancy rate and pregnancy. Results The patients in study group with normal ovulation rate was 72.7%, the control group with normal ovulation rate was 62.3% (P > 0.05), no significant difference. 2 cases of study group 18 cases of pregnancy, abortion; control group of 8 cases of pregnancy, abortion 3 cases, statistically significant differences between the two groups (P < 0.05). Conclusion Polycystic ovarian syndrome complicated with infertility patients undergoing ovulation induction therapy before metformin, Diane-35 35

  1. 自发性不育男性中谷胱甘肽S转移酶Mu-1基因的缺失使其精子和精浆的氧化损伤程度增加%Increased oxidative damage of sperm and seminal plasma in men with idiopathic infertility is higher in patients with glutathione S-transferase Mu-1 null genotype

    Institute of Scientific and Technical Information of China (English)

    B.Aydemir; I.Onaran; A.R.Kiziler; B.Alici; M.C.Akyolcu

    2007-01-01

    Aim:To examine whether a relationship exists between glutathione S-transferase Mu-1 (GSTM1) gene polymorphism and the susceptibility of sperm and seminal plasma from patients with idiopathic infertility to oxidative stress.Methods: Fifty-two men with idiopathic infertility and 60 healthy fertile men were recruited to this study. GSTM1 gene polymorphism was determined by polymerase chain reaction (PCR) and both the infertile and control individuals were divided into GSTM1 null and GSTM1 positive groups according to their GSTM1 gene structure. We compared reactive oxygen species (ROS) generation, malondialdehyde (MDA), protein carbonyls and glutathione (GSH) concentrations, and glutathione S-transferase (GST) activity in seminal plasma and spermatozoa from infertile patients and controls with respect to GSTM1 genotype. Results: Significantly higher levels of oxidative stress and damage markers were found in idiopathic infertile men with the GSTM1 null genotype compared with those with the GSTM1 positive genotype. There was no significant difference in genotype distribution for the GSTM1 variant between the idiopathic infertile subjects and fertile subjects. Patients with the GSTM1 null genotype also had lower sperm concentrations than those with GSTM1 positive genotype. Conclusion: Our results suggest that the susceptibility of sperm and seminal plasma to oxidative stress is significantly greater in idiopathic infertile men with the GSTM1 null genotype compared with those possessing the gene. Therefore, in patients with idiopathic infertility,GSTM1 polymorphism might be an important source of variation in susceptibility of spermatozoa to oxidative damage.

  2. Enhanced Fertility after Diagnostic Hysterosalpingography in Unexplained Infertility

    Directory of Open Access Journals (Sweden)

    M Fallah- Tafti

    2009-07-01

    Full Text Available Introduction: Infertility is a common complication present in 10-15% of the population. It causes serious problems for the family. There are different methods for evaluation and treatment of infertility. One of the routine tests is hysterosalpingography that was first used in1922 and with changes in types of contrast media and its techniques, it is the primary test for simultaneous evaluation of tube, uterus body and cervix. Methods: This descriptive clinical outcome study was carried out on the base of a case series study. The study was performed on 117 patients who referred for HSG procedure and were followed for 2 years for detection of pregnancy. Data was analyzed by SPSS.14, and statistical tests included student’s t-test, chi-square and Fisher exact test. Results: The mean age of patients was 26±4.7 years. Duration of infertility was 6 years. Of the total, 98(83.8% cases had one or both patent tubes on HSG. They didn’t have any established causes of infertility after scrutiny of other findings and 51(43.6% cases became pregnant during 2 years (CI=95%,34.6-52.6%. Notable point was that 86.3% of pregnancies occurred in the first 6-months after HSG procedure. Conclusion: HSG plays a significant role in infertility diagnosis and treatment in spite of the new techniques and methods for infertility diagnosis and treatment; so follow up and control of patient for 6 months after HSG is recommended. If HSG fails, other procedures such as laparoscopy can be done.

  3. Evaluation of Risk Factors Associated with Endometriosis in Infertile Women

    Science.gov (United States)

    Ashrafi, Mahnaz; Sadatmahalleh, Shahideh Jahanian; Akhoond, Mohammad Reza; Talebi, Mehrak

    2016-01-01

    Background Endometriosis affects women’s physical and mental wellbeing. Symptoms include dyspareunia, dysmenorrhea, pelvic pain, and infertility. The purpose of this study is to assess the correlation between some relevant factors and symptoms and risk of an endometriosis diagnosis in infertile women. Materials and Methods A retrospective study of 1282 surgical patients in an infertility Institute, Iran between 2011 and 2013 were evaluated by laparoscopy. Of these, there were 341 infertile women with endometriosis (cases) and 332 infertile women with a normal pelvis (comparison group). Chi-square and t tests were used to compare these two groups. Logistic regression was done to build a prediction model for an endometriosis diagnosis. Results Gravidity [odds ratio (OR): 0.8, confidence interval (CI): 0.6-0.9, P=0.01], parity (OR: 0.7, CI: 0.6-0.9, P=0.01), family history of endometriosis (OR: 4.9, CI: 2.1-11.3, Pgalactorrhea (OR: 2.3, CI: 1.5-3.5, P=0.01), history of pelvic surgery (OR: 1.9, CI: 1.3-2.7, P0.05). Fatigue, diarrhea, constipation, dysmenorrhea, dyspareunia, pelvic pain and premenstrual spotting were more significant among late-stage endometriosis patients than in those with early-stage endometriosis and more prevalent among patients with endometriosis than that of the comparison group. In the logistic regression model, gravidity, family history of endometriosis, history of galactorrhea, history of pelvic surgery, dysmenorrhoea, pelvic pain, dysparaunia, premenstrual spotting, fatigue, and diarrhea were significantly associated with endometriosis. However, the number of pregnancies was negatively related to endometriosis. Conclusion Endometriosis is a considerable public health issue because it affects many women and is associated with the significant morbidity. In this study, we built a prediction model which can be used to predict the risk of endometriosis in infertile women. PMID:27123195

  4. Evaluation of Risk Factors Associated with Endometriosis in Infertile Women

    Directory of Open Access Journals (Sweden)

    Mahnaz Ashrafi

    2016-05-01

    Full Text Available Background: Endometriosis affects women’s physical and mental wellbeing. Symptoms include dyspareunia, dysmenorrhea, pelvic pain, and infertility. The purpose of this study is to assess the correlation between some relevant factors and symptoms and risk of an endometriosis diagnosis in infertile women. Materials and Methods: A retrospective study of 1282 surgical patients in an infertility Institute, Iran between 2011 and 2013 were evaluated by laparoscopy. Of these, there were 341 infertile women with endometriosis (cases and 332 infertile women with a normal pelvis (comparison group. Chi-square and t tests were used to compare these two groups. Logistic regression was done to build a prediction model for an endometriosis diagnosis. Results: Gravidity [odds ratio (OR: 0.8, confidence interval (CI: 0.6-0.9, P=0.01], parity (OR: 0.7, CI: 0.6-0.9, P=0.01, family history of endometriosis (OR: 4.9, CI: 2.1-11.3, P0.05. Fatigue, diarrhea, constipation, dysmenorrhea, dyspareunia, pelvic pain and premenstrual spotting were more significant among late-stage endometriosis patients than in those with early-stage endometriosis and more prevalent among patients with endometriosis than that of the comparison group. In the logistic regression model, gravidity, family history of endometriosis, history of galactorrhea, history of pelvic surgery, dysmenorrhoea, pelvic pain, dysparaunia, premenstrual spotting, fatigue, and diarrhea were significantly associated with endometriosis. However, the number of pregnancies was negatively related to endometriosis. Conclusion: Endometriosis is a considerable public health issue because it affects many women and is associated with the significant morbidity. In this study, we built a prediction model which can be used to predict the risk of endometriosis in infertile women.

  5. Genotyping of Israeli infertile men with idiopathic oligozoospermia.

    Science.gov (United States)

    Madgar, I; Green, L; Kent-First, M; Weissenberg, R; Gershoni-Baruch, R; Goldman, B; Friedman, E

    2002-09-01

    Microdeletions of the long arm of the Y chromosome involving the azoospermia factor (AZF) region are associated with severe oligo- or azoospermia. Abnormal androgen receptor (AR) structure or function has also been implicated in male infertility. To assess the contribution of these genetic defects to male infertility, 61 Israeli men with severe oligo- (n = 15) or azoospermia (n = 46), were screened for Y chromosome microdeletions, and the AR-(CAG)n repeat length. Fifty fertile Israeli men were similarly analyzed. PCR amplification of 20-54 simple tag sequences (STSs) located at Yq was used to determine the rate and extent of Y chromosome microdeletions. PCR with primers flanking the AR-(CAG)n region and subsequent size fractionation on gradient acrylamide gels were used to determine AR-(CAG)n length. Five azoospermic individuals (5/61-8.2% and 5/46-10.8% of azoospermic patients) displayed Y chromosome microdeletions. The mean CAG repeat number in infertile men was 18.6 +/- 3.0 compared with 16.6 + 2.7 in fertile men (n = 50), a statistically significant difference (p = 0.003). Y chromosome microdeletions contribute to male infertility in our azoospermic population, and the mean length of the AR-CAG is significantly longer in our infertile population than in fertile men.

  6. The biology of infertility: research advances and clinical challenges

    Science.gov (United States)

    Matzuk, Martin M; Lamb, Dolores J

    2013-01-01

    Reproduction is required for the survival of all mammalian species, and thousands of essential ‘sex’ genes are conserved through evolution. Basic research helps to define these genes and the mechanisms responsible for the development, function and regulation of the male and female reproductive systems. However, many infertile couples continue to be labeled with the diagnosis of idiopathic infertility or given descriptive diagnoses that do not provide a cause for their defect. For other individuals with a known etiology, effective cures are lacking, although their infertility is often bypassed with assisted reproductive technologies (ART), some accompanied by safety or ethical concerns. Certainly, progress in the field of reproduction has been realized in the twenty-first century with advances in the understanding of the regulation of fertility, with the production of over 400 mutant mouse models with a reproductive phenotype and with the promise of regenerative gonadal stem cells. Indeed, the past six years have witnessed a virtual explosion in the identification of gene mutations or polymorphisms that cause or are linked to human infertility. Translation of these findings to the clinic remains slow, however, as do new methods to diagnose and treat infertile couples. Additionally, new approaches to contraception remain elusive. Nevertheless, the basic and clinical advances in the understanding of the molecular controls of reproduction are impressive and will ultimately improve patient care. PMID:18989307

  7. [Infertility over forty: Pros and cons of IVF].

    Science.gov (United States)

    Belaisch-Allart, J; Maget, V; Mayenga, J-M; Grefenstette, I; Chouraqui, A; Belaid, Y; Kulski, O

    2015-09-01

    The population attempting pregnancy and having babies is ageing. The declining fertility potential and the late age of motherhood are increasing significantly the number of patients over forty consulting infertility specialists. Assisted reproductive technologies (ART) cannot compensate the natural decline in fertility with age. In France, in public hospital, ART is free of charge for women until 43 years, over 43, social insurance does not reimburse ART. Hence, 43 years is the usual limit, but between 40 and 42 is ART useful? The answer varies according to physicians, couples or society. On medical level, the etiology of the infertility must be taken into account. If there is an explanation to infertility (male or tubal infertility) ART is better than abstention. If the infertility is only due to age the question is raised. In France, the reimbursement by the society of a technique with very low results is discussed. However efficacy is not absolutely compulsory in Medicine. On the opposite to give false hopes may be discussed too. To obtain a reasonable consensus is rather difficult.

  8. [Evaluation of the male of the infertile couple].

    Science.gov (United States)

    Freour, T; Delvigne, A; Barrière, P

    2010-12-01

    The exploration of male infertility combines clinical examination and complementary analysis, including biology and ultrasonography. The purpose of this review is to analyze the data available on the accuracy of interview, testicular ultrasonography, sperm analysis and post-coital test. Medical history and patient's interview remain central in the exploration of the infertile man. Despite some limitations, studies on testicular sonography confirm the high prevalence of testicular lesions in infertile men. Up to now, sperm analysis remains the pivotal element of the exploration of male fertility. The new WHO manual for semen analysis published in 2010 should help in redefining its place in the global exploration of male infertility. Despite its statutory character in France, the interest of systematic sperm bacterial examination remains to be demonstrated. Concerning sperm DNA fragmentation, its use as a first-line test should not be recommended. Finally, high levels of evidence do not exist concerning the use of post-coital test as a predictor of pregnancy in infertile couples. Copyright © 2010 Elsevier Masson SAS. All rights reserved.

  9. Seminal biomarkers for the evaluation of male infertility

    Directory of Open Access Journals (Sweden)

    Jared M Bieniek

    2016-01-01

    Full Text Available For men struggling to conceive with their partners, diagnostic tools are limited and often consist of only a standard semen analysis. This baseline test serves as a crude estimation of male fertility, leaving patients and clinicians in need of additional diagnostic biomarkers. Seminal fluid contains the highest concentration of molecules from the male reproductive glands, therefore, this review focuses on current and novel seminal biomarkers in certain male infertility scenarios, including natural fertility, differentiating azoospermia etiologies, and predicting assisted reproductive technique success. Currently available tests include antisperm antibody assays, DNA fragmentation index, sperm fluorescence in situ hybridization, and other historical sperm functional tests. The poor diagnostic ability of current assays has led to continued efforts to find more predictive biomarkers. Emerging research in the fields of genomics, epigenetics, proteomics, transcriptomics, and metabolomics holds promise for the development of novel male infertility biomarkers. Seminal protein-based assays of TEX101, ECM1, and ACRV1 are already available or under final development for clinical use. Additional panels of DNA, RNA, proteins, or metabolites are being explored as we attempt to understand the pathophysiologic processes of male infertility. Future ventures will need to continue data integration and validation for the development of clinically useful infertility biomarkers to aid in male infertility diagnosis, treatment, and counseling.

  10. Mendelian genetics of male infertility

    Science.gov (United States)

    Hwang, Kathleen; Yatsenko, Alexander N.; Jorgez, Carolina J.; Mukherjee, Sarmistha; Nalam, Roopa Lata; Matzuk, Martin M.; Lamb, Dolores J.

    2013-01-01

    Infertility is defined as the inability of a couple to conceive despite trying for a year, and it affects approximately 15% of the reproductive-age population. It is considered a genetically lethal factor, as the family lineage stops at that individual with no progeny produced. A genetic defect associated with an infertile individual cannot be transmitted to the offspring, ensuring the maintenance of reproductive fitness of the species. However, with the advent of assisted reproductive techniques (ART), we are now able to overcome sterility and bypass nature’s protective mechanisms that developed through evolution to prevent fertilization by defective or deficient sperm. PMID:21382200

  11. THE CHANGING FACE OF MEDICINE IN THE 21ST CENTURY – THE EXAMPLE OF INFERTILE CLOMID FAILED INSULIN RESISTANT POLYCYSTIC OVARIAN PATIENTS SUBMITTED TO ASSISTED REPRODUCTIVE THERAPY (ART I N PAKISTAN

    Directory of Open Access Journals (Sweden)

    Sarwat Jehan

    2014-12-01

    Full Text Available The outcome of metformin administration in insulin resistant infertile polycystic ovary syndrome (PCOS patients who had failed clomid. The research was conducted at the University Assisted Reproductive Techniques (ART Institute in Pakistan – a developing country with a high prevalence of diabetes. 166 PCOS patients submitted to ART out of 277 referrals (59.9%. Of these 78 (47% achieved pregnancies with 75.6% take home babies and 24.4% reproductive failure prior to ART, Intra Cytoplasmic Sperm Injection (ICSI and In Vitro Fertilization (IVF. The total healthy take home baby rate was 47% of the 166 patients. These seventy eight (78 patients became pregnant prior to ART after starting metformin for insulin resistance. 88 required ART and 19 of these delivered a healthy baby. Metformin (500 to 2500 mg daily was started prior to pregnancy and continued throughout pregnancy. Metformin 1500 mg daily for 3 months resulted in 59 live and well neonates averaging 3.1kg. Metformin <1500 mg daily and / or administration for less than 3 months prior to Pregnancy resulted in 18 abortions and 1 intrauterine death at 30 weeks gestation with no live neonate. Almost 50% became pregnant without ART. When ART was needed 19 out of 88 patients delivered a live baby. Almost 50% of patients with failed ART elsewhere became pregnant on this regime with take home healthy babies and 6 did not require ART. Metformin 1500mg daily administrated for at least 3 months prior to pregnancy and continued throughout pregnancy had an uncomplicated neonatal outcome in 59 patients compared to lower doses or shorter duration of administration in 19 patients who had a uniformly poor pregnancy outcome. The European Society of Human Reproduction and Embryology (ESHRE and American Society for Reproductive Society (ASRM guidelines are biologically and statistically flawed. In South Asia infertile PCOS patients require a long term life cycle approach. Early insulin resistance should be

  12. Infertility and Life Satisfaction among Women

    Science.gov (United States)

    McQuillan, Julia; Stone, Rosalie A. Torres; Greil, Arthur L.

    2007-01-01

    Using data from a random sample of 580 midwestern women, the authors explore the association between lifetime infertility and life satisfaction. Past research shows lower life satisfaction among those seeking help for infertility. The authors find no direct effects of lifetime infertility, regardless of perception of a problem, on life…

  13. Spermatozoal protein profiles in male infertility with asthenozoospermia

    Institute of Scientific and Technical Information of China (English)

    LI Hong-jun; YU Ning; ZHANG Xin-yu; JIN Wei; LI Han-zhong

    2010-01-01

    Background Infertility is a major medical and social problem, and elementary research on the spermatozoal proteins and their functions are relatively scarce and there are very few confirmed and effective options for the treatment of male infertility. Thus, it is essential to find candidate proteins that affect male infertility. This study was designed to detect the proteins with differential expression in sperm from infertile patients and normal donors.Methods Semen samples from patients with idiopathic asthenozoospermia (n=114) and from fertile men with normal spermiograms (n=37) were collected. Semen sample analysis, sperm protein extraction, SDS-PAGE electrophoresis and Western blotting analysis were performed. Results were analyzed by SPSS 16.0 statistical software.Results Western blotting analysis of spermatic proteins displayed a major differentially expressed protein in spermatozoa from fertile and idiopathic asthenozoospermia patients. Densities and volumes of the identified protein in the patients were significantly decreased compared to normal donors (P=0.034 and P=0.036, respectively). The protein was identified as DEAD-box protein 4 (DDX4, VASA). The expression and correction value (CV) of DDX4/VASA in the patients was reduced significantly compared to normal donors (P=0.037 and P=0.031, respectively).Conclusions The expression of spermatic protein DDX4/VASA associates with spermatic motility, implying that DDX4NASA may be a candidate marker for evaluation of spermatic motility.

  14. Zeta Sperm Selection Improves Pregnancy Rate and Alters Sex Ratio in Male Factor Infertility Patients: A Double-Blind, Randomized Clinical Trial

    Directory of Open Access Journals (Sweden)

    Nasr Esfahani Mohammad Hossein

    2016-07-01

    Full Text Available Background Selection of sperm for intra-cytoplasmic sperm injection (ICSI is usually considered as the ultimate technique to alleviate male-factor infertility. In routine ICSI, selection is based on morphology and viability which does not necessarily preclude the chance injection of DNA-damaged or apoptotic sperm into the oocyte. Sperm with high negative surface electrical charge, named “Zeta potential”, are mature and more likely to have intact chromatin. In addition, X-bearing spermatozoa carry more negative charge. Therefore, we aimed to compare the clinical outcomes of Zeta procedure with routine sperm selection in infertile men candidate for ICSI. Materials and Methods From a total of 203 ICSI cycles studied, 101 cycles were allocated to density gradient centrifugation (DGC/Zeta group and the remaining 102 were included in the DGC group in this prospective study. Clinical outcomes were com- pared between the two groups. The ratios of Xand Y bearing sperm were assessed by fluorescence in situ hybridization (FISH and quantitative polymerase chain reaction (qPCR methods in 17 independent semen samples. Results In the present double-blind randomized clinical trial, a significant increase in top quality embryos and pregnancy rate were observed in DGC/Zeta group compared to DGC group. Moreover, sex ratio (XY/XX at birth significantly was lower in the DGC/Zeta group compared to DGC group despite similar ratio of X/Y bearings sper- matozoa following Zeta selection. Conclusion Zeta method not only improves the percentage of top embryo quality and pregnancy outcome but also alters the sex ratio compared to the conventional DGC method, despite no significant change in the ratio of Xand Ybearing sperm population (Registration number: IRCT201108047223N1.

  15. The efficacy of metformin and clomiphene citrate combination compared with clomiphene citrate alone for ovulation induction in infertile patients with PCOS

    Directory of Open Access Journals (Sweden)

    Papa Dasari

    2009-01-01

    Full Text Available Context: Low ovulatory and pregnancy rates with clomiphene citrate (CC in anovulatory polycystic ovarian syndrome (PCOS. Aim: To find out the ovulatory and pregnancy rates in infertile PCOS subjects who receive CC alone and a combination of metformin and CC. Setting and Design: A prospective controlled clinical trial conducted in the outpatient department from August 2003 to August 2005. Materials and Methods: Twenty-four infertile PCOS women received CC alone at incremental doses of 50 mg up to 150 mg for three cycles and then at a dose of 150 mg for another three cycles (control group. The study group (16 PCOS received the same dose of CC along with 1500mg of metformin. Ovulation was monitored by transvaginal sonography up to six cycles or till pregnancy occurred. Statistical Analysis: This was carried out using software SSPS, version 10. Fisher′s exact test was used to calculate the ovulatory rates. Nine subjects of the control group who failed to conceive with CC had opted for CC and metformin and their ovulatory rate was calculated using statistical software, namely SPSS 15.0, Stata 8.0, MedCalc 9.0.1 and Systat 11.0 using Fischer′s exact test. Results: The metformin and clomiphene combination resulted in a significantly higher rate of ovulation ( P = 0.0016. The pregnancy rate was 8% with CC and 24% with metformin and CC. The CC failure group also ovulated at a similar rate as that of the study group. Conclusions: The ovulatory rate and the pregnancy rate with the metformin-CC combination was found to be higher when compared with CC alone. Metformin increased the ovulatory rate in CC failures, also implying increased sensitivity to CC.

  16. Psychological stress and infertility. Part 2: Psychometric test data.

    Science.gov (United States)

    Brand, H J

    1982-12-01

    The hypothesis tested in this study was that a group of female functional infertile patients would show significantly more personality maladjustment than a group with definite organic reproductive pathology and a normal fertile group. No significant differences between the functional and organic groups were found on any of the subscores of four personality questionnaires. The normal group (wives of sterile men) scored higher on extraversion than both the functional and organic groups. On self-control the normal group also scored lower (negative connotation) than the other two groups. In general no evidence for personality maladjustment in functional infertility was found.

  17. Is infertility after surgery for cryptorchidism congenital or acquired?

    DEFF Research Database (Denmark)

    Cortes, D; Thorup, J M; Visfeldt, J

    1998-01-01

    We evaluated whether deletions of the DAZ (deleted in azoospermia) gene, abnormal karyotypes or hypogonadotropic hypogonadism (HH) were demonstrable in infertile men who had undergone surgery in childhood for cryptorchidism with a simultaneous testicular biopsy that demonstrated no or almost...... no germ cells. In six men with infertility after surgery for cryptorchidism, the adult karyotype and analyses for the DAZ gene, serum follicle-stimulating hormone, luteinizing hormone, and testosterone were performed from a peripheral blood sample. Testicular volume was also measured. All patients...

  18. Causes of infertility in men with Down syndrome.

    Science.gov (United States)

    Stefanidis, K; Belitsos, P; Fotinos, A; Makris, N; Loutradis, D; Antsaklis, A

    2011-10-01

    Men with Down syndrome are considered as infertile although the causes of infertility are not known in detail yet. Although this constitutes a general rule there are three confirmed cases of parenting by fathers with Down syndrome. Many investigators have addressed the causes of infertility and their studies indicate that the causes may be hormonal deficits, morphological alterations of the gonads, abnormal spermatogenesis, psychological and social factors related to the mental retardation. It is obvious that the extra chromosome 21 has a detrimental direct and indirect effect on the reproductive capacity of the affected male patient. But the definite cause of the insufficient and inadequate spermatogenesis remains to be discovered. © 2011 Blackwell Verlag GmbH.

  19. Is infertility after surgery for cryptorchidism congenital or acquired?

    DEFF Research Database (Denmark)

    Cortes, Dina; Thorup, J M; Visfeldt, J

    1998-01-01

    We evaluated whether deletions of the DAZ (deleted in azoospermia) gene, abnormal karyotypes or hypogonadotropic hypogonadism (HH) were demonstrable in infertile men who had undergone surgery in childhood for cryptorchidism with a simultaneous testicular biopsy that demonstrated no or almost...... no germ cells. In six men with infertility after surgery for cryptorchidism, the adult karyotype and analyses for the DAZ gene, serum follicle-stimulating hormone, luteinizing hormone, and testosterone were performed from a peripheral blood sample. Testicular volume was also measured. All patients...... exhibited a 46,XY karyotype. There were no deletions of the DAZ-gene, no HH and no testicular atrophy. The infertility was thus not proved to be congenital, and consequently, surgical treatment is indicated before the germ cells disappear from undescended testes. This appears to be before 15 months of age....

  20. Ultrastructural Study of an Atypical Case of Infertility

    Directory of Open Access Journals (Sweden)

    Ernesto Sánchez Sánchez

    2007-01-01

    Full Text Available An atypical case of infertility associated with severe sperm abnormalities is presented. A 29-year-old man with 4 years of primary infertility had no history of significant illness, and no hereditary pathology or male infertility existed in his family. Physical examination of the patient showed no pathological findings. The analyses of four semen samples showed: sperm count, 67-83 106/ml; 0% motility. The morphological analysis showed absence of flagellum, 14-16%; short-tail spermatozoa, 45-64%; coiled tails, 12-17%; and an abnormal proportion of spermatids and spermatocytes. Normal spermatozoa were found in 11-16%. Endocrine profile was found within the normal range. Testicular biopsy revealed impaired spermatogenesis. Scanning electron microscopy revealed sperm heads with intact nuclei and acrosomal regions. To our surprise, some of the stunted tails were uniflagellate. To our knowledge, this is a very uncommon case of sperm tail defect.

  1. 饮酒对男性不育患者精液质量及精子DNA完整性的影响分析%The analysis of alcohol influence the male infertility patients' semen quality and sperm DNA integrity

    Institute of Scientific and Technical Information of China (English)

    王琛

    2013-01-01

    Objective:Discuss the influence of alcohol on male infertility patients' semen quality and sperm DNA integrity.Methods:Select 73 male infertility patients who long term drinking (greater than 10 years) as alcohol group,and 112 Non drinking healthy male as contrast group.Detect two groups' semen and sperm DNA integrity.Results:The sperm density,motility and percentage of A -class sperm motility of alcohol group were significantly lower than that Non drinking group P < 0.05).Sperm DNA fragmentation index (DFI) also increased significantly (P < 0.05).The two groups showed significant difference.Conclusion:Long-term drinking influence semen quality and sperm's DNA integrity.%目的 探讨饮酒对男性不育患者精液质量及精子DNA完整性的影响.方法 选择73例长期饮酒(酒龄大于10年)的男性不育患者为饮酒组,对照组为112例非饮酒的健康正常男性,对其进行精液常规及精子DNA完整性检测.结果 饮酒组的精子密度、活率和A级精子活力百分率明显低于对照组(P<0.05),精子DNA断裂指数(DFI)明显增高(P<0.05),两组差别有显著性意义.结论 长期饮酒会对男性精液质量产生不良影响及损伤男性精子DNA的完整性.

  2. Outcome and influencing factors analysis of palace laparoscopy in treatment of infertile patients with fallopian tube%宫腹腔镜诊治输卵管性不孕患者结局及影响因素分析

    Institute of Scientific and Technical Information of China (English)

    彭汝娇; 刘姜伶; 郑诗丹; 梁红梅; 余红秀; 方云

    2016-01-01

    Objective By exploring natural pregnancy rate and its related influencing factors of after the operation of palace laparoscopy to infertile patients with fallopian tube, to provide basis for doctors to accurately assess the opportunity of natural pregnancy after tubal infertility and to select the appropriate pregnancy program. Methods 93 cases of infertile patients with fallopian tube using palace laparoscopy operation with 2 year complete follow-up records were selected as the study objects. Natural pregnancy rate after operation was analyzed. They were divided into pregnancy group and non-pregnancy group according to natural pregnancy or not after operation. The main factors influencing the pregnancy rate after operation were aimed to find out. Results Among the 93 cases of patients, there were 36 cases of natural pregnancy within 2 years after palace laparoscopy operation, and the total natural pregnancy rate was 38.71%(36/93). The total natural pregnancy rate within 6 months was 30.11%(28/93).There were 6 cases of the total natural pregnancy rate within 7-12 months after operation.The cumulative natural pregnancy rate was 36.56%within 1 year after operation, which was close to total pregnancy rate.There were 2 cases of the total natural pregnancy rate within 13-24 months after operation.Pregnancy rate 1 year after operation was decreased significantly (P<0.05). In the relevant influencing factors, history of infertility, abortion, history of pelvic surgery and pelvic inflammatory disease, combined pelvic endometriosis, moderate and severe pelvic adhesion 7 factors were significant impacted on the postoperative pregnancy rate of the patients (P<0.05). Conclusion Infertility diagnosis should be treated as soon as possible, once it is established. After the operation, doctors should provide the optimal and individualized follow-up conception for the patients with the infertility, the related history and the operation condition. For the patients, whose fallopian

  3. A potential tool for diagnosis of male infertility: Plasma metabolomics based on GC-MS.

    Science.gov (United States)

    Zhou, Xinyi; Wang, Yang; Yun, Yonghuan; Xia, Zian; Lu, Hongmei; Luo, Jiekun; Liang, Yizeng

    2016-01-15

    Male infertility has become an important public health problem worldwide. Nowadays the diagnosis of male infertility frequently depends on the results of semen quality or requires more invasive surgical intervention. Therefore, it is necessary to develop a novel approach for early diagnosis of male infertility. According to the presence or absence of normal sexual function, the male infertility is classified into two phenotypes, erectile dysfunction (ED) and semen abnormalities (SA). The aim of this study was to investigate the GC-MS plasma profiles of infertile male having erectile dysfunction (ED) and having semen abnormalities (SA) and discover the potential biomarkers. The plasma samples from healthy controls (HC) (n=61) and infertility patients with ED (n=26) or with SA (n=44) were analyzed by gas chromatography-mass spectrometry (GC-MS) for discrimination and screening potential biomarkers. The partial least squares-discriminant analysis (PLS-DA) was performed on GC-MS dataset. The results showed that HC could be discriminated from infertile cases having SA (AUC=86.96%, sensitivity=78.69%, specificity=84.09%, accuracy=80.95%) and infertile cases having ED (AUC=94.33%, sensitivity=80.33%, specificity=100%, accuracy=87.36%). Some potential biomarkers were successfully discovered by two commonly used variable selection methods, variable importance on projection (VIP) and original coefficients of PLS-DA (β). 1,5-Anhydro-sorbitol and α-hydroxyisovaleric acid were identified as the potential biomarkers for distinguishing HC from the male infertility patients. Meanwhile, lactate, glutamate and cholesterol were the found to be the important variables to distinguish between patients with erectile dysfunction from those with semen abnormalities. The plasma metabolomics may be developed as a novel approach for fast, noninvasive, and acceptable diagnosis and characterization of male infertility.

  4. Risk of major congenital malformations associated with infertility and its treatment by extent of iatrogenic intervention.

    Science.gov (United States)

    Farhi, Jacob; Fisch, Benjamin

    2007-06-01

    Cumulative evidence from large cohort studies, multicenter studies, and meta-analyses suggests that assisted reproductive technologies are associated with an elevated risk of congenital malformations. Theoretically, there are several putative factors in infertility treatments which may be related to the development of congenital malformations. These include, in part, the exposure to gonadotrophin stimulation and the exposure to supra-physiological levels of E2; the altered physiological environment of implantation; the in-vitro culture conditions at early stages of embryonic development; the artificial selection of sperm for fertilization and the sperm injection process in ICSI and the process of embryo cryopreservation. However, it is also possible that the culprit is not the infertility treatment that leads to the increased risk of congenital malformations but a factor or factors inherent to infertile patients. The aim of this review is to present the current data, summarize it and define the association between major congenital malformation and different types of infertility treatments as well as to infertility per se. We conducted an extensive search of the medical literature (Pubmed, 1985-2006) to identify all data relating major congenital malformations to infertile couples, infertility treatments or to characteristics of the infertile population. The rates of congenital malformations associated with infertility were analyzed by the degree of iatrogenic intervention to better define the relative risks. The findings confirmed the increased risk of congenital malformations in relation to in vitro fertilization even in singleton infants. There was no difference in the occurrence of major congenital malformations by either the laboratory maneuvers of sperm or embryos of varying complexity or by the specific medications used for ovarian stimulation or luteal support. Increased risk for congenital malformations was also found in infertile couples in relation to

  5. Hysterolaparoscopy in the Evaluation and Management of Female Infertility.

    Science.gov (United States)

    Kabadi, Y M; Harsha, B

    2016-10-01

    To study the role of hysterolaparoscopy in the evaluation and management of female infertility. A retrospective study of the 94 case files of all the patients who underwent diagnostic hysterolaparoscopy for infertility between January 2014 to June 2015 in the department of Obstetrics and Gynecology, Karnataka Institute of Medical Sciences, Hubli. These infertile women were confirmed to have normal ovulatory cycles, hormonal assays and seminogram report. Dye studies as well as inspection for abnormal pelvic and intrauterine pathology and necessary therapeutic interventions were done during the procedure. Abnormal pelvic and intrauterine pathology by hysterolaparoscopy were categorized. Out of 94 cases, 53.1 % patients had primary, 17.1 % patients had secondary infertility, and 29.8 % came for tubal recanalization. As a whole pelvic pathology was confirmed in 51.7 % and intrauterine pathology in 18.1 % patients by hysterolaparoscopy. The most common laparoscopic abnormality detected was ovarian pathology (20.8 %), followed by pelvic inflammatory disease (17.5 %). Tubal block comprised 7.7 % whereas distorted uterus by fibroid in 6.6 % and pelvic endometriosis in 5.4 %. In hysteroscopy, the incidence of uterine anomaly was 13 (13.8 %). Septate uterus is the most common with a mean incidence of approximately 7 (53.8 %). Diagnostic hysterolaparoscopy is an effective diagnostic and therapeutic modality for certain significant and correctable abnormalities in pelvis, tubes and uterus which are missed by other imaging modalities.

  6. Infertility factors at the Groote Schuur Hospital Fertility Clinic

    African Journals Online (AJOL)

    1989-07-15

    Jul 15, 1989 ... the rest between 2 and 5 factors contributed to the infertility of the couple. ... The selection criteria at the Fertility Clinic at Groote Schuur. Hospital .... explained by the fact that most of the patients were referred by private ...

  7. Outcome of Loupe-Assisted Sub-inguinal Varicocelectomy in Infertile Men

    OpenAIRE

    Abdelrahman, Selim S.; Eassa, Bayoumy I.

    2012-01-01

    Background Sub-inguinal varicocelectomy is widely used among surgeons. Objectives The aim of this study was to evaluate the outcome of varicocelectomy using a modified microsurgical method, specifically a loupe-assisted method, and its effects on sperm parameters in infertile men. Patients and Methods This study was performed in 40 patients who presented with varicocele. All patients had at least a 1-year history of infertility with abnormal semen parameters and varicocele proven by physical ...

  8. 不孕不育症患者婚姻调适状况及其与人格特征的相关性%Correlation between marital adjustment and personality characteristics in infertile patients

    Institute of Scientific and Technical Information of China (English)

    邓桂英; 王文兰; 欧阳结颜; 关纪红

    2014-01-01

    目的:探讨不孕不育症患者婚姻调适状况及其与人格特征的相关性。方法采用Locke-Wollance婚姻调适测定量表和艾森克人格问卷(Eysenck personality questionnaire,EPQ),对156例不孕不育症已婚患者进行问卷调查。了解患者婚姻调适状况及其与人格特征的相关性。结果156例不孕不育症患者婚姻调适总分为(100.7±15.5)分,其中婚姻调适良好为51.3%,婚姻失调为48.7%;婚龄≤5年组较婚龄>5年组患者婚姻调适好(P<0.01)。在人格特征中精神质(P)、神经质(N)维度得分为倾向型,内外向(E)和掩饰性(L)维度得分为中间型;婚姻调适良好组与婚姻失调组、婚龄≤5年组与婚龄>5年组患者人格特征在精神质(P)、内外向(E)和神经质(N)维度得分比较,差异具有统计学意义(均P<0.01);患者婚姻调适与精神质(P)、神经质(N)维度呈负相关,与内外向(E)维度呈正相关;患者婚龄与精神质(P)、神经质(N)则呈正相关,与内外向(E)、掩饰性(L)维度呈负相关。结论不孕不育症患者家庭婚姻失调较多,婚姻调适与婚龄影响不孕不育症患者人格特征。提示不孕不育症患者影响其身心健康,应早期对其进行心理干预,特别是对于婚姻调适不良及婚龄>5年患者。%Objective To study the correlation between marital adjustment and personality characteristics in infertile patients. Method The Locke-Wollance marital adjustment measurement scale and Eysenck personality questionnaire(EPQ)were used among 156 patients with infertility to investigate the correlation between marital adjustment and personality characteristics in infertile patients. Results The total score on the marital adjustment was(100.7±15.5). The rate of good marital adjustment was 51.3%and the rate of marital maladjustment was 48.7%. Those with a marital time of shorter than 5

  9. Abnormal expression of centrosome protein (centrin) in spermatozoa of male human infertility

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    To study the relations between male infertility and centrosome protein (centrin) and the functions of centrin in spermatogenesis, the matured spermatozoa of 10 normal male people and 18 male infertility patients were stained by immunofluorescence labeling antibody against centrin. The results showed that two fluorescence signal dots appeared in the normal male spermatozoa and were located at the base of flagellum. They are proximal centriole and distal centriole. However, in some spermatozoa of the male infertility, centrin protein was located abnormally at the base of flagellum and its staining signals were spread, the normal proximal and distal centrioles were confused and could not be recognized separately. These results suggest that abnormality of centrosome protein may be related to male infertility. This discovery may be used as a marker of abnormal sperm and male infertility.

  10. Genetic aspects of human male infertility: the frequency of chromosomal abnormalities and Y chromosome microdeletions in severe male factor infertility.

    Science.gov (United States)

    Vicdan, Arzu; Vicdan, Kubilay; Günalp, Serdar; Kence, Aykut; Akarsu, Cem; Işik, Ahmet Zeki; Sözen, Eran

    2004-11-10

    The main purpose of this study is to detect the frequency and type of both chromosomal abnormalities and Y chromosome microdeletions in patients with severe male factor infertility and fertile control subjects. The association between the genetic abnormality and clinical parameters was also evaluated. This study was carried out in 208 infertile and 20 fertile men. Results of 208 patients, 119 had non-obstructive azoospermia and 89 had severe oligoasthenoteratozoospermia (OAT). Seventeen out of 119 (14.3%) azoospermic patients and two out of 89 (2.2%) patients with OAT had Y chromosome microdeletions. In total, 19 cases with deletions were detected in 208 infertile men, with a frequency of 9.1%. The AZFc locus, mainly DAZ gene cluster was the most frequently deleted region. Five other cases with azoospermia (4.2%) and two cases with OAT (2.2%) had a chromosomal abnormality, with a total number of seven (3.4%). Including Y chromosome deletions and structural chromosome abnormalities, the rate of genetic abnormalities was 12.5% (26/208) in our patients. On the other hand, 20 men with proven fertility and fathers of five cases with microdeletions were genetically normal. Y chromosome deletions and chromosomal abnormalities were associated with various histological alterations in testis. Sertoli cell-only (SCO) syndrome and maturation arrest predominated in these cases, whereas hypospermatogenesis occurred more frequently in genetically normal patients. Various chromosomal abnormalities and deletions of Y chromosome can cause spermatogenic breakdown resulting in chromosomally derived infertility. All these findings strongly support the recommendation of genetic screening of infertile patients.

  11. Unexplained infertility: association with inherited thrombophilia.

    Science.gov (United States)

    Fatini, Cinzia; Conti, Lucia; Turillazzi, Valentina; Sticchi, Elena; Romagnuolo, Ilaria; Milanini, Maria Novella; Cozzi, Cinzia; Abbate, Rosanna; Noci, Ivo

    2012-05-01

    Unexplained infertility represents one of the most common diagnoses in fertility care. Attention is being paid to the association between inherited thrombophilia and infertility causes. In this study we investigated the prevalence of inherited thrombophilia according to infertility causes. We studied Prothrombin gene G20210A mutation, Factor V Leiden, deficiencies in protein S and C and antithrombin in 930 Caucasian infertile women referred to Fertility Center of the Department of Sciences for Woman and Child's Health, University of Florence, of whom 230 with unexplained, 195 female and 283 male infertility, and in 240 women who have conceived naturally without hormonal stimulation therapy. A significant relationship between inherited thrombophilia [OR 95%CI 1.97 (1.05-3.68), p = 0.03] and unexplained infertility was observed, whereas no association between thrombophilia and female and male infertility was found. Significantly higher prevalence of prothrombin gene mutation in unexplained infertile women in comparison to that observed in fertile women was observed (5.7% vs 2.1% p = 0.04); the prevalence of the other thrombophilia determinants was higher, even if not significantly, in the unexplained infertile group. This study demonstrates the relationship between inherited thrombophilia and unexplained infertility, thus suggesting the contribution of genetic components in modulating unexplained infertility, behind anovulation, male and tubal factor. Copyright © 2012 Elsevier Ltd. All rights reserved.

  12. Psychological Factors Affecting Infertile Women

    Directory of Open Access Journals (Sweden)

    Sati Unal

    2010-10-01

    Full Text Available AIM: This study was performed to determine the psychological factors affecting infertile women presenting at the infertility outpatients department. METHOD: The sample of this cross-sectional study consisted of 344 women who presented at the IVF center of a special branch hospital or a university hospital, March 2008 through September 2008, as determined by the non-random sampling method. All participating women gave their informed consent. The data were collected using the Data Form that consisted of questions on socio-demographic features and the Infertility Distress Scale (IDS. In the results, percentages were provided along with the Kruskal-Wallis H, Mann-Whitney U and Spearman correlation tests. RESULTS: The mean IDS was 39.01±9.6. There was a statistically significant linear relationship between the mean IDS score and age (r=0.106, p=0.048, marriage duration (r=0.232, p<0.001 and duration of desire to have a child (r=0.217, p<0.001. Women who were primary school graduates (X²=13.03, p=0.004, did not work (p=0.007, had no social security benefits (p=0.021 or from low socioeconomic status (X²=24.85, p<0.001 had significantly higher mean IDS scores. CONCLUSION: The results of this study show women become more adversely affected by infertility as their age, duration of marriage, and duration of desire to have a child increase. Women who are primary school graduates, do not work, have no social security benefits or have lower income are affected more negatively. We believe that taking these features into account when evaluating and planning supportive approaches for women presenting at the infertility treatment center and determining the psychological state of the women using the IDS will increase treatment success. [TAF Prev Med Bull 2010; 9(5.000: 481-486

  13. Analysis of the spermatic vein blood gas from the infertility patients with varicocele%精索静脉曲张不育症患者精索静脉血气分析

    Institute of Scientific and Technical Information of China (English)

    杨营利; 王雷

    2013-01-01

    目的 探讨精索静脉曲张(varicocele,VC)导致男性不育的具体发病机制.方法 选择50例VC不育症患者及40例对照组作为研究对象,分别取其左侧精索内静脉以及周围静脉血进行血气分析,然后比较.结果 (1)VC不育症患者左侧精索静脉血中的PH、PO2、SO2及HCO3-低于外周静脉血(P<0.05),PCO2及K+高于外周静脉血(P<0.05),而其他指标差异无统计学意义(P>0.05).(2)VC不育症患者左侧精索静脉血中的PH、PO2、SO2及HCO3-低于对照组(P<0.05),40例对照组PCO2及K+高于对照组(P<0.05),而其他指标差异无统计学意义(P>0.05).(3)VC不育症患者精液密度及活率低于对照组(P<0.05),畸形率高于对照组(P<0.05).结论 VC不育症患者精索静脉中的PH、PO2、SO2、HCO3-降低和PCO2、K+升高是导致精液密度及活率降低同时畸形率升高进而引起男性不育的原因.%Objectives To investigate the nosogenesis of why varicosele can result in infertility.Methods The left spermatic and peripheral vein blood was taken from 50 infertility patients with varicocele and 40 normal cases,and the blood gas was mearsured.Results (1) The PH,PO2,SaO2,HCO3-of the left spermatic vein blood was lower than that of the peripheral vein blood from the male with varicocele (P < 0.05),the PCO2,K + of the left spermatic vein blood was higher than that of the peripheral vein blood from the male with varicocele(P <0.05),but the other indexof them was not significant(P > 0.05).(2) The PH,PO2,SaO2,HCO3-of the left spermatic vein blood from the male with varicocele was lower than that from the normal male(P < 0.05),the PCO2,K + of the left spermatic vein blood from the male with varicocele was higher than that from the normal male(P <0.05),but the other index of them was not significant(P > 0.05).(3)The density and motility rate of sperm fromthe male with 4 varicocele was lower than that from the normal male(P < 0.05),and the abnormal rateof

  14. Clinical value of serum immune antibody detection in infertile patients and treatment experiment%不孕症患者血清免疫性抗体检测的临床价值与治疗体会

    Institute of Scientific and Technical Information of China (English)

    姜玉娟

    2016-01-01

    目的:研究不孕症患者血清免疫性抗体检测的临床价值。方法选取吉林省人口生命科学技术研究院2013~2014年收治的不孕症患者150例为观察组,正常生育妇女150例为对照组,观察组患者给予肾上腺皮质激素类和隔绝疗法进行治疗。比较两组治疗前抗精子抗体( Antisperm antibody,AsAb)、抗子宫内膜抗体(Endometrial antibody,EMAb)、抗卵巢抗体(antiovary antibody,AoAb)、抗透明带抗体(Anti zona pellucida antibodies,AzpAb)阳性比例的差异和观察组治疗前后的变化情况,并评价疗效。结果观察组治疗前AsAb阳性、EMAb 阳性、AoAb 阳性、AzpAb 阳性的例数(34、17、11、10)均高于对照组(2、1、1、1)( P <0.05);观察组治疗后AsAb阳性、EMAb阳性、AoAb阳性、AzpAb阳性的例数(19、7、3、3)低于治疗前(34、17、11、10)(P<0.05)。观察组治疗后自然受孕和人工受孕的例数高于治疗前的例数(8 vs 0,16 vs 0)(P <0.05)。结论免疫抑制治疗不孕有良好的效果,通过检测和分析自身免疫抗体的变化诊断和治疗不孕症具有可行性,值得临床推广应用。%Objective To study the clinical value of serum immune antibody detection in infertile patients. Methods 150 infertile patients who were treated in population life science and technology institute of Jilin province from March 2013 to March 2015 were selected as observation group, and 150 normal reproductive women were selected as control group. The observation group was treated with adrenal cortical hormone and isolated therapy. The differences of positive rate of AsAb, EMAb, AoAb and AzpAb of two groups before treatment were compared, and in order to investigate the effect of treatment, a contrast observation of AsAb, EMAb, AoAb and AzpAb of oberservation group was made. Results The rates of AsAb positive, EMAb positive, AoAb positive and AzpAb positive of observation group were higher than those of the control group(P<0. 05). The

  15. The effects of tomato juice on male infertility.

    Science.gov (United States)

    Yamamoto, Yu; Aizawa, Koichi; Mieno, Makiko; Karamatsu, Mika; Hirano, Yasuko; Furui, Kuniko; Miyashita, Tatsuya; Yamazaki, Kazumitsu; Inakuma, Takahiro; Sato, Ikuo; Suganuma, Hiroyuki; Iwamoto, Teruaki

    2017-01-01

    This study aimed to investigate the effects of tomato juice consumption on seminal plasma lycopene levels and sperm parameters in infertile men. Subjects were male infertility patients with poor sperm concentration (juice group, an antioxidant group, and a control group. The subjects in the tomato juice group and the antioxidant group daily consumed one can of tomato juice (containing 30 mg of lycopene) or one antioxidant capsule (containing vitamin C 600 mg, vitamin E 200 mg, and glutathione 300 mg), respectively, for 12 weeks (feeding period). Seminal plasma lycopene levels and sperm parameters were measured every 6 weeks during the feeding period. Forty-four patients completed the study (control group: 12, antioxidant group: 15, tomato juice group: 17). In the tomato juice group, plasma lycopene level was significantly increased at the 12th week of the feeding period. Moreover, a decrease in seminal plasma white blood cells and an increase in sperm motility in the tomato juice group were statistically significant at the 12th and 6th weeks, respectively, compared to the control group. In the antioxidant capsule group, no significant improvement was observed in semen parameters. In conclusion, regular consumption of tomato juice seems to improve sperm motility in infertile patients. This is the first report to show that commercially available food, such as tomato juice, might be beneficial for male infertility.

  16. A new strategy for professional medical support couples with infertility

    Directory of Open Access Journals (Sweden)

    O. B. Zhukov

    2013-01-01

    Full Text Available From our point of view, the problem of infertility in a pair of appropriately addressed jointly by the two related disciplines. This process has been actively helping set newsupplements Spematon and Pregnoton. The study included 50 couples planning to conceive: 25 couples with male factor infertility secretory type (group 1, 25 couples with infertility caused by varicocele in the postoperative period (group 2. The first group included patients with hyperprolactinemia relative to a second group – 25 somatically healthy patients. All groups patients takes Spematon and Pregnoton during 3 months. Terms of infertility in couples ranged from 1 to 4,5 years and an average reached 2,8 ± 1,6 years. According to the results of the comparative analysis the reproductive value of sperm had been enhanced, functional status of the female reproductive system had been improved, the menstrual cycle had been normalized and relatively elevated levels of prolactin had been decreased after co-application of these supplements. Five woman became pregnant.

  17. The association between male infertility and sperm disomy: Evidence for variation in disomy levels among individuals and a correlation between particular semen parameters and disomy of specific chromosome pairs

    Directory of Open Access Journals (Sweden)

    Wright David

    2004-12-01

    Full Text Available Abstract Background The association between infertility and sperm disomy is well documented. Results vary but most report that men with severely compromised semen parameters have a significantly elevated proportion of disomic sperm. The relationship between individual semen parameters and segregation of specific chromosome pairs is however less well reported as is the variation of disomy levels in individual men. Methods In order to address these questions the technique of fluorescent in-situ hybridisation (FISH was utilised to determine the disomy levels of chromosomes X, Y and 21 in 43 sperm samples from 19 infertile males. The results generated from this study were analysed using logistic regression. Results In this study we compared levels of sperm concentration, motility and morphology with levels of sperm disomy for chromosome 21 and the sex chromosomes. Our results suggest that there is considerable variation in disomy levels for certain men. They also suggest that oligozoospermic males have significantly elevated levels of sex chromosome disomy but not disomy 21; they suggest that severe asthenozoospermic males have significantly elevated levels of disomy 21 but not sex chromosome disomy. Surprisingly, severe teratozoopsermic males appeared to have significantly lower levels of sperm disomy for both the sex chromosomes and chromosome 21. Conclusion We suggest that the association between sex chromosome disomy and oligozoospermia may be due to reduced recombination in the XY pairing region and discuss the relevance of our findings for the correlations between sperm disomy and sperm motility and morphology.

  18. Tuberculosis of the cervix and infertility: report of a rare case.

    Science.gov (United States)

    Guié, P; Iovenitti, P; N'guessan, K; Tegnan, J; Koffi, K; Carta, G; Anongba, S

    2008-01-01

    Tubercolosis is a frequent bacterial infection in less developed countries. Lung and lymph node localisations are common, while the genital apparatus is less involved. In this work a rare case of cervical tuberculosis followed by some lesions causing infertility in a 20-year-old woman is reported. The diagnosis was confirmed by a histological examination from a biopsy of the cervix. The patient was offered six-month antituberculosis therapy which eliminated the cervical lesions. A few years later she came under our care for infertility due to uterine adhesions diagnosed by hysterosalpingography. Now the patient is being treated for infertility complicated by amenorrhoea.

  19. Clinical, genetic, biochemical, and testicular biopsy findings among 1,213 men evaluated for infertility.

    Science.gov (United States)

    Olesen, Inge Ahlmann; Andersson, Anna-Maria; Aksglaede, Lise; Skakkebaek, Niels Erik; Rajpert-de Meyts, Ewa; Joergensen, Niels; Juul, Anders

    2017-01-01

    To study the pathologic findings among men evaluated for infertility. A retrospective, single-center, cross-sectional study. University hospital-based research center. We included data from 1,213 medical records from infertile men referred for diagnostic work-up from 2005 to 2009. None. Health history, clinical findings, chromosome/genetic aberrations, semen quality, reproductive hormones. In total, 64.4% of the infertile men had one or more reproductive disorders or factors influencing fertility, leaving 35.6% diagnosed as idiopathic infertile. In 244 patients (20%), including seven cases of testicular cancer and/or germ cell neoplasia in situ, a pathologic finding was first detected during diagnostic work-up. Two hundred four patients (16.8%) had a history of cryptorchidism and 154 (12.7%) of varicocele (grade 2 and 3). Thirty-three patients had chromosomal abnormalities, including 16 with sex chromosome abnormalities (11 with 47,XXY). Y-chromosome microdeletions were detected in 65 patients (5.4%). One hundred thirty-three had azoospermia, of which 58 had testicular biopsy findings (Sertoli cell-only syndrome: n = 23; spermatogenic arrest: n = 7; impaired spermatogenesis and atrophy: n = 28). Additionally, in idiopathic infertile men and infertile men with additional symptoms of testicular dysgenesis syndrome, 22.5% presented with a degree of Leydig cell insufficiency, with the highest frequency (33.1%) among patients with sperm concentration infertility in two-thirds of infertile men referred to our center. Thus, male infertility may be a sign of an underlying disease that warrants attention. Copyright © 2016. Published by Elsevier Inc.

  20. 聚焦解决模式在男性不育症患者微创取精术中的应用%Application of Solution Focused Approach for Male Infertile Patients Undergoing Microtraumatic Sperm Extraction

    Institute of Scientific and Technical Information of China (English)

    甘蔚明; 邓妙玲; 马胜利

    2014-01-01

    目的:探讨聚焦解决模式在男性不育症患者微创取精术中的应用效果。方法以聚焦解决模式为依据,制订干预措施,并应用于65例男性不育微创取精术患者中。干预8~10次,持续3个月,采用自尊心和性关系问卷(泽藻造枣-藻泽贼藻藻皂葬灶凿则藻造葬-贼蚤燥灶泽澡蚤责择怎藻泽贼蚤燥灶灶葬蚤则藻,杂耘A砸)和生活定向测验(蕴韵栽-砸)评估患者的心理及行为状况。结果干预后患者的杂耘A砸得分比干预前明显提高,比较差异有统计学意义(孕<0.01);干预后符合悲观倾向的由58例下降到17例,符合乐观倾向的由7例上升至48例,干预前后生活定向测验(蕴韵栽-砸)得分差异有统计学意义(孕<0.01)。结论以聚焦解决模式为基础的护理干预,能为男性不育微创取精术患者提供有效的心理护理和行为指导。%Objective To explore the effect of application of solution focused approach for male infertile patients who underwent microtraumatic sperm extraction. Methods We carried out intervention plans on the basis of solution focused approach and applied these plans in 65 male patients with infertility who underwent microtraumatic sperm extraction. These patients received intervention eight to ten times in three months, and then their psychological and behavioural conditions were assessed by SEAR and LOT-R. Results After the intervention, the patients' SEAR scores were significantly higher than those before the intervention (P <0.01);the number of patients with pessimism declined from 58 to 17, while the number of patients with optimism increased from 7 to 48. The differences in the scores of LOT-R before and after the intervention had statistic significance (P<0.01). Conclusions The nursing intervention based on solution focused approach can provide male patients with infertility who underwent microtraumatic sperm extraction with effective psychological nursing and

  1. 夫精人工授精前对不孕症患者的伦理关怀%Ethical Care for Infertile Patients before AIH( Artificial Insemination by Husband)

    Institute of Scientific and Technical Information of China (English)

    田晓华; 赵邦霞; 陈冬丽

    2011-01-01

    实施夫精人工授精术前给予不孕患者适当的伦理关怀,消除患者困惑、压抑、自卑心理,保障不孕患者的基本权利,帮助其树立治疗信心,让此项技术更好地造福于不孕不育患者,同时规范医疗机构和医务人员的医疗行为,并对实施夫精人工授精过程中产生的伦理问题提出探讨.%Before the implementation of AIH, ethical care for infertile patients is of great benefits. For instance, it will help to eliminate patient's negative psychological states such as confusion, depression, and self-abasement. And it also protects patient's basic legal rights and helps them to pump up confidence for treatment. Therefore, the pre - AIH ethical care could enable AIH to better benefit the patients, and meanwhile regulate the medical behaviors of medical institutions and professionals. This paper also explores relevant ethical issues in the implementation of AIH.

  2. Effects of the level of seminal plasma fructose on the infertile patients with reproductive tract infections%生殖道感染对男性不育患者精浆果糖的影响

    Institute of Scientific and Technical Information of China (English)

    毛金观; 李琴

    2015-01-01

    ObjectiveTo investigate the correlation between male infertility patients with reproductive tract infection and seminal plasma fructose.Methods1 390 patients were divided into asthenozoospermia (691 cases), normal group (422 cases), oligospermia (134 cases), severe oligozoospermia (62 cases), obstructive azoospermia (39 cases), non-obstructive azoospermia (24 cases), oligozoospermia (18 cases). Retrospectively analyzed the sperm quality of male infertility patients and seminal plasma fructose and seminal plasma elastase data.Results Compared with normal group, the seminal plasma fructose levels of obstructive azoospermia group and oligospermia group all showed significantly decreasing (t=5.049, 2.797,P<0.05). The non obstructive azoospermia showed significantly increasing (t=2.985,P<0.05). In normal sperm group, the seminal plasma fructose level of the confirmed infection patients compared with normal group showed significant decreasing (t=2.844,P<0.05). In oligospermia group, the seminal plasma fructose level of the confirmed infection patients compared with normal group also showed significant decreasing (t=2.647,P<0.05).ConclusionThe level of seminal plasma fructose can reduce in the infertile patients with reproductive tract infections.%目的:探讨男性不育患者生殖道感染与精浆果糖的相关性。方法选择2008年7月至2012年6月嘉兴市妇幼保健院收治的1390例不育症患者,分为弱精子症(691例)、正常精子组(422例)、少弱精子症(134例)、严重少精子症(62例)、梗阻性无精子症(39例)、非梗阻性无精子症(24例)、少精子症(18例)。回顾性分析男性不育患者的精子质量与精浆果糖及精浆弹性硬蛋白酶资料。结果(1)与正常精子组比较,梗阻性无精子症、弱精子症患者的精浆果糖水平降低,差异有统计学意义(t=5.049、2.797,均P<0.05);非梗阻性无精子症的精浆果糖水平增高,

  3. 新疆地区男性不育患者人乳头瘤病毒感染和抗精子抗体的回顾性研究%Retrospective analysis of association between human papilloma virus infection and antisperm antibodies in male infertile patients in Xinjiang area

    Institute of Scientific and Technical Information of China (English)

    杨晓芳; 张英; 王欣

    2015-01-01

    Objective To explore the association between human papilloma virus(HPV)infection and antisperm antibodies(As-Ab)in male infertile patients in Xinjiang area.Methods A total of 127 cases of infertile male patients were selected as experimental group,other 130 cases of normal male were enrolled in the control group.HPV sperm infection was detected by using reverse dot blot hybridization kit.The levels of AsAbs in semen specimen were measured by using the enzyme-linked immunosorbent assay (ELISA).Results The infection rate of male infertile patients(67.7%)was higher than that of normal male(1 6.2%),with signifi-cant differences(P <0.05).The positive rate of AsAb of male infertile patients with HPV infection(38.4%)was higher than that of male infertile patients without HPV infection(1 7.1%),with significant differences(P <0.05).Compared with male infertile pa-tients without HPV infection,the percentages of sperm motility and grade (a+b)sperm motility were decreased in male infertile pa-tients with HPV infection,wihile the sperm malformation rate was increased in male infertile patients with HPV infection,with sig-nificant differences(P <0.05).Conclusion The HPV infection rate of male infertile patients is relatively high in this area.HPV sperm infection could be associated with AsAb that may further reduce male fertility.%目的:探讨新疆地区男性不育患者人乳头瘤病毒(HPV)感染与抗精子抗体(AsAb)的关系。方法选取127例男性不育患者作为试验组,130例正常生育男性作为对照组。采用反向斑点杂交方法检测 HPV 精液感染,采用酶联免疫吸附试验(ELISA)检测精液中 AsAb 水平。结果男性不育患者 HPV 感染率(67.7%)高于正常生育男性 HPV 感染率(16.2%),差异有统计学意义(P <0.05);HPV 精液感染的男性不育患者,AsAb 阳性率(38.4%)高于无 HPV 感染的不育男性(17.1%),差异具有统计学意义。与 HPV 感染阴性男性不育患者比较,HPV 感染男性不育患者

  4. Genetic screening in infertile Mexican men: chromosomal abnormalities, Y chromosome deletions, and androgen receptor CAG repeat length.

    Science.gov (United States)

    Martínez-Garza, Sandra Guadalupe; Gallegos-Rivas, Mayra Celina; Vargas-Maciel, Marcos; Rubio-Rubio, Juan Manuel; de Los Monteros-Rodríguez, Mario Espinosa; González-Ortega, Claudia; Cancino-Villarreal, Patricia; de Lara, Luis G Vazquez; Gutiérrez-Gutiérrez, Antonio Martín

    2008-01-01

    In our study, we analyzed chromosomal abnormalities, Y chromosome deletions, androgen receptor CAG repeat length and their association with defective spermatogenesis in infertile Mexican men. Eighty-two infertile patients and 40 controls were screened for karyotypic abnormalities, Y chromosome microdeletions, and CAG repeats. Nine infertile males (11%) carried chromosomal abnormalities and 10 (12.2%) presented Y chromosome microdeletions. The mean CAG repeat length was 21.6 and 20.88 base pairs in idiopathic infertile males and controls, respectively. Our results suggest that chromosomal aberrations and Y-chromosomal microdeletions are related to male infertility in Mexican men. In addition, expansion of the CAG repeat segments of the androgen receptor is not correlated with male idiopathic infertility.

  5. Evolution of psychology and counseling in infertility.

    Science.gov (United States)

    Boivin, Jacky; Gameiro, Sofia

    2015-08-01

    Five key paradigm shifts are described to illustrate the evolution of psychology and counseling in infertility. The first paradigm shift was in the 1930s when psychosomatic concepts were introduced in obstetrics and gynecology as causal factors to explain why some couples could not conceive despite the absence of organic pathology. In the second shift, the nurse advocacy movement of the 1970s stimulated the investigation of the psychosocial consequences of infertility and promoted counseling to help couples grieve childlessness when medical treatments often could not help them conceive. The third shift occurred with the advent of IVF, which created a demand for mental health professionals in fertility clinics. Mental health professionals assessed the ability of couples to withstand the demands of this new high technology treatment as well as their suitability as potential parents. The fourth shift, in the 1990s, saw reproductive medicine embrace the principles of evidence-based medicine, which introduced a much more rigorous approach to medical practice (effectiveness and safety) that extended to psychosocial interventions. The most recent paradigm shift, in the new millennium, occurred with the realization that compliance with protracted fertility treatment depended on the adoption of an integrated approach to fertility care. An integrated approach could reduce treatment burden arising from multiple sources (i.e., patient, clinic, and treatment). This review describes these paradigm shifts and reflects on future clinical and research directions for mental health professionals.

  6. Polycystic ovaries and infertility: Our experience

    Directory of Open Access Journals (Sweden)

    Lavanya Rajashekar

    2008-01-01

    Full Text Available Background: Polycystic ovary syndrome (PCOS is one of the most common (15-20% endocrine disorders in women of childbearing age. Although it is a major cause of infertility, its etiology remains unknown and its treatment difficult. Aim: To evaluate the incidence, treatment and outcome of patients with PCOS. DESIGN: Retrospective analysis. Materials and Methods: PCOS patients (914 of the 1057 attending the outpatient department (OPD from June 2003 to February 2008 were evaluated for this study. Of the 914 patients investigated, 814 came for treatment and these patients were studied for hormonal disturbances and their response to various modalities of treatment. Results: Of the 2270 infertility patients, 46.50% (1057 had PCOS, out of these, 86.47% (914 were investigated and 77% (814 came for treatment. Our overall pregnancy rate was 48.40% (394/814. The pregnancy rate per cycle with timed intercourse (TI was 44.77% (47/105, 17.09% (286/1673 with intrauterine insemination (IUI, 29.82% (51/171 with in vitro fertilization (IVF and 22.22% (10/45 with frozen embryo transfer (FET. The maximum number of pregnancies (85.29%, 284/333 were achieved in the first three treatment cycles. The abortion rate was 19.01% (73/384 and the incidence of ectopic pregnancy was 5.47% (21/384. Complications seen were in the form of ovarian hyperstimulation (OHSS, retention cyst on day two and multiple pregnancies in 11.71% (228/1946 of the total treatment cycles. Conclusion: Most PCOS symptoms could be adequately controlled or eliminated with proper diagnosis and treatment. Thus, ovulation induction (OI protocols and treatment modalities must be balanced for optimal results.

  7. Comparison of Hysterosalpingography and Combined Laparohysteroscopy for the Evaluation of Primary Infertility.

    Science.gov (United States)

    Nigam, A; Saxena, P; Mishra, A

    2015-01-01

    Background Hysterosalpingography (HSG) is a useful screening test for the evaluation of female infertility. Laparoscopy has proven role in routine infertility work up but role of hysteroscopy in an infertile patient with normal HSG for additional information is a subject of debate. Hysteroscopy permits direct visualization of the cervical canal and the uterine cavity and thereby helping in the evaluation of shape, and cavitary lesion. Objective To detect uterine abnormalities in infertile women by various approaches i.e. HSG and hysteroscopy and evaluating the role of combining hysteroscopy with laparoscopy for the evaluation of tubo-uterine factor for primary infertility. Method One twenty eight infertile women were evaluated and HSG was performed as a basic test for evaluation of tubes and uterine cavity. Women were subjected to combined laparoscopic and hysteroscopic examination on evidence of HSG abnormalities. In absence of any HSG abnormality, women were subjected to ovulation induction for three to six months and if they did not conceive during this period they were undertaken for combined laparo-hysteroscopic evaluation. Result The positive predictive value of HSG for detecting the intrauterine abnormalities was 70% among 126 patients where the hysteroscopy could be performed successfully. The diagnostic accuracy of HSG for intrauterine abnormalities revealed false negative rate of 12.96%. The most frequent pathologies encountered by laparoscopy were tubal and/or peritoneal and were found in 68% (87/128) of women. Total 64.06% infertile women had some abnormality on laparoscopy. This detection rate has been increased from 64.06% to 71.86% on including the concomitant hysteroscopy. Conclusion HSG is a good diagnostic modality to detect uterine as well as tubal abnormalities in infertile patient. HSG and hysteroscopy are complementary to each other and whenever the patient is undertaken for diagnostic laparoscopy for the infertility, hysteroscopy should be

  8. A Survey on Infertility in Royan Institute

    Directory of Open Access Journals (Sweden)

    Mohammad Kamali

    2007-01-01

    Full Text Available Background: Infertility is defined as failure in pregnancy after one year of unprotected intercourse.Several centers have reported different causes of infertility. The most common causes of infertility are:male factor such as sperm disturbance, female factor such as ovulation dysfunction and tubal factor,both male and female factor, and unexplained infertility .The aim of this study was to survey theepidemiology of infertility in Royan institute.Material and Methods: In this descriptive retrospective study, 2492 infertile couples were studied.These couples were selected by systematic sampling among couples referred to Royan institutebetween 1995 and 2001.All existing demographic data and diagnostic methods were recorded inquestionnaires .Results were analyzed using SPSS version 11.5.Results: In this study, the frequency of primary and secondary infertility was 90.1% and 9.9%,respectively. Among 2492 couples, 50.5% had male factor, 28.6% had female factor, 11.6% had bothmale and female factors and in 9.3% of couples, the cause of infertility was unknown .Results showedthat 32.3% of men had normal spermogram, 23.6% of couples had azoospermia, and 40.3% had spermdisturbance including oligospermia, asthenospermia, oligoasthenospermia and teratospermia .3.8%were not able to collect sample for semen analysis. Among women, different infertility factors included:ovarian factor (20.36%, tubal factor (12.64%, uterine factor (4.13%, endometriosis (1.28% andrecurrent abortion (0.68%. 50.48% of women were normal.Conclusion: Although male factor was the most common cause of infertility in Royan institute, we cannot conclude that this factor is the most common cause of infertility in Iran since this center isconsidered referral especially for male infertility. We suggest performance of similar researches inother centers to evaluate the most common causes of infertility in Iran.

  9. Traditional Chinese medical herbs staged therapy in infertile women with endometriosis: a clinical study

    OpenAIRE

    Ding, Zhaorong; Lian, Fang

    2015-01-01

    Background: Endometriosis is a common gynecological disease defined as the presence of endometrioid tissue (glands and stroma) outside the uterus. About 30 to 40% patients with endometriosis are infertile. In traditional Chinese medical system, endometriosis associated infertility is mostly caused by kidney deficiency and blood stasis. The herb of reinforcing kidney and removing blood stasis is designed to treat the disease. Material and methods: All the 80 up-to-standard patients were divide...

  10. Ozone Therapy in Treatment of Female Infertility

    Directory of Open Access Journals (Sweden)

    Maradi A. Burduli

    2015-03-01

    Full Text Available Ozone therapy and physiotherapy have been successfully used in obstetric practice. The paper summarizes the results of studies on the use of ozone therapy in the postoperative rehabilitation of gynecological patients operated on for female infertility of various origins. Biomechanisms systemic impact methods of ozone therapy on the human body to meet the requirements of the tactics of the impact on the etiopathogenic mechanisms of chronic inflammatory diseases of the pelvic organs and their complications. It is advisable to wider use of ozone therapy in the complex treatment standards gynecological patients. Postoperative rehabilitation, including ozone therapy, can have a significant impact on the clinical course of gynecological and extragenital pathology, pregnancy rate and its outcomes.

  11. Value of hysteroscopy in management of unexplained infertility

    Directory of Open Access Journals (Sweden)

    Aisha M. Elbareg

    2014-12-01

    Conclusion: As a cause of unexplained infertility, subtle uterine abnormalities are diagnosed only during hysteroscopy and they are relatively common in infertility women. Although the presence of these abnormalities is not detected by the basic investigations for infertility, their correction seems to be necessary when infertility is desired and other infertility causes are excluded.

  12. 中西医结合治疗高催乳素血症不孕症临床分析%Clinical Analysis of Traditional Chinese and Western Medicine Treatment on Infertility Patients with Hyperprolactinemia

    Institute of Scientific and Technical Information of China (English)

    徐碧红; 李茂清

    2012-01-01

    目的:观察中西医治疗高催乳素血症不孕症患者43例的的临床疗效.方法:将86例高催乳素不孕症患者,随机分为对照组、治疗组两组.对照组43例患者给予溴隐亭治疗,治疗组加服自拟疏肝补肾汤,连服3个月.观察两组患者的临床疗效、性激素[包括催乳素(PRL)、黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)、孕酮(P)、睾酮(T)]水平,临床症状积分及妊娠情况等.结果:治疗组、对照组的临床疗效95.3%、79.1%;治疗后两组均可降低PRL水平,提高E2、P水平(P>0.05);但治疗组在临床症状改善方面明显优于对照组(P<0.05);治疗组妊娠率显著高于对照组(P<0.05).结论:中西医治疗高催乳素血症不孕症具有良好的疗效,可改善患者临床症状,提高妊娠率,减少溴隐亭的不良反应,值得临床推广应用.%Objective: To observe the effect of traditional Chinese and western medicine treatment on 43 infertility patients with hyperprolactinemia. Methods;S6 patients of infertility with high prolaetin were randomly divided into control group and treatment group. 43 patients in the control group were given bromocriptine,the treatment group also took liver -soothing and kidney - nourishing decoction for 3 months. The clinical efficacy, sex hormones (including PRL,LH,FSH, E2, P, T) levels, clinical symptom score and pregnancy rate were observed. Results: The clinical efficacy of treatment group and control group were 95. 3% and 79. 1 % ;after treatment the two groups could reduce PRL levels effectively and improve E2,P levels( P >0. 05 ) ;but in the treatment groups clinical symptoms improvement were better than that in the control group( P <0.05) ;the pregnancy rate of treatment group was significantly higher than that of the control group( P <0.05). Conclusion: Traditional Chinese and western medicine treatment has good curative effect on infertility patients with hyperprolactinemia and can improve clinical

  13. Comprehensive 5-Year Study of Cytogenetic Aberrations in 668 Infertile Men

    Science.gov (United States)

    Yatsenko, Alexander N.; Yatsenko, Svetlana A.; Weedin, John W.; Lawrence, Amy E.; Patel, Ankita; Peacock, Sandra; Matzuk, Martin M.; Lamb, Dolores J.; Cheung, Sau Wai; Lipshultz, Larry I.

    2010-01-01

    Purpose The causes of male infertility are heterogeneous but more than 50% of cases have a genetic basis. Specific genetic defects have been identified in less than 20% of infertile males and, thus, most causes remain to be elucidated. The most common cytogenetic defects associated with nonobstructive azoospermia are numerical and structural chromosome abnormalities, including Klinefelter syndrome (47,XXY) and Y chromosome microdeletions. To refine the incidence and nature of chromosomal aberrations in males with infertility we reviewed cytogenetic results in 668 infertile men with oligozoospermia and azoospermia. Materials and Methods High resolution Giemsa banding chromosome analysis and/or fluorescence in situ hybridization were done in 668 infertile males referred for routine cytogenetic analysis between January 2004 and March 2009. Results The overall incidence of chromosomal abnormalities was about 8.2%. Of the 55 patients with abnormal cytogenetic findings sex chromosome aneuploidies were observed in 29 (53%), including Klinefelter syndrome in 27 (49%). Structural chromosome abnormalities involving autosomes (29%) and sex chromosomes (18%) were detected in 26 infertile men. Abnormal cytogenetic findings were observed in 35 of 264 patients (13.3%) with azoospermia and 19 of 365 (5.2%) with oligozoospermia. Conclusions Structural chromosomal defects and low level sex chromosome mosaicism are common in oligozoospermia cases. Extensive cytogenetic assessment and fluorescence in situ hybridization may improve the detection rate in males with oligozoospermia. These findings highlight the need for efficient genetic testing in infertile men so that couples may make informed decisions on assisted reproductive technologies to achieve parenthood. PMID:20172548

  14. Male factor infertility and ART

    Institute of Scientific and Technical Information of China (English)

    Herman Tournaye

    2012-01-01

    For years,the management and treatment of male factor infertility has been ‘experience’ and not ‘evidence’ based.Although not evidence-based,current clinical practice involves extensive use of assisted reproductive techniques (ART).Where specific treatments are not indicated or have failed,ART have become popular adjunctive treatments for alleviating male factor infertility.According to the limited evidence available,intrauterine insemination (IUI) may be considered as a first-line treatment in a couple in which the female partner has a normal fertility status and at least 1x 106 progressively motile spermatozoa are recovered after sperm preparation.If no pregnancy is achieved after 3-6 cycles of IUI,optimized in vitro fertilization (IVF) can be proposed.When less than 0.5x 106 progressively motile spermatozoa are obtained after seminal fluid processing or sperm are recovered surgically from the testis or epididymis,intracytoplasmic sperm injection (ICSI) should be performed.Although the outcome of no other ART has ever been scrutinized as much before,no large-scale ‘macroproblems’ have as yet been observed after ICSI.Yet,ICSI candidates should be rigorously screened before embarking on IVF or ICSI,and thoroughly informed of the limitations of our knowledge on the hereditary aspects of male infertility and the safety aspects of ART.

  15. Predictive value of hormonal parameters for live birth in women with unexplained infertility and male infertility

    National Research Council Canada - National Science Library

    Murto, Tiina; Bjuresten, Kerstin; Landgren, Britt-Marie; Stavreus-Evers, Anneli

    2013-01-01

    .... The objective of the present study was to characterize hormone levels in an arbitrary menstrual cycle in women with unexplained infertility and male infertility, and to determine the predictive value...

  16. Relevance of genetic investigation in male infertility.

    Science.gov (United States)

    Asero, P; Calogero, A E; Condorelli, R A; Mongioi', L; Vicari, E; Lanzafame, F; Crisci, R; La Vignera, S

    2014-05-01

    Genetic causes can be directly responsible for various clinical conditions of male infertility and spermatogenic impairment. With the increased use of assisted reproduction technologies our understanding of genetic basis of male infertility has large implications not only for understanding the causes of infertility but also in determining the prognosis and management of such couples. For these reasons, the genetic investigations represent today an essential and useful tool in the treatment of male infertility. Several evidences are available for the clinical practice regarding the diagnosis; however, there are less information relative to the treatment of the genetic causes of male infertility. Focus of this review is to discuss the main and more common genetic causes of male infertility to better direct the genetics investigation in the treatment of spermatogenic impairment.

  17. Understanding Infertility and the Potential Role of Stem Cells in Infertility Treatment: A Short Communication

    OpenAIRE

    Chirputkar R; Vaidya A

    2015-01-01

    Infertility is increasing at a great rate across the globe. Various male as well as female factors are known to contribute to infertility. Although hormonal replacement therapy and assisted reproduction treatments like in vitro fertilization and intracytoplasmic sperm injection are well established clinical modalities to treat infertility, stem cells are now being considered as potentially new therapeutic agents for the treatment of infertility due to their high differentiation potential. Sev...

  18. Predictive value of hormonal parameters for live birth in women with unexplained infertility and male infertility

    OpenAIRE

    Murto, Tiina; Bjuresten, Kerstin; Landgren, Britt-Marie; Stavreus-Evers, Anneli

    2013-01-01

    Background: Infertile women might get pregnant sometime after fertility treatment, but today, there is no prediction model on who will eventually have children. The objective of the present study was to characterize hormone levels in an arbitrary menstrual cycle in women with unexplained infertility and male infertility, and to determine the predictive value for long-term possibility of live birth. Methods: In this cross-sectional study, with 71 infertile women with diagnosis unexplained infe...

  19. Domestic violence in Iranian infertile women

    OpenAIRE

    Sheikhan, Zohre; Ozgoli, Giti; Azar, Mahyar; AlaviMajd, Hamid

    2014-01-01

    Background: Millions of men and women suffer from infertility worldwide. In many cultures, infertile women are at risk of social and emotional problems. Infertility may affect the public health in many countries. Domestic violence is the intentional use of physical force, power or threat against oneself, another person or another group or community which leads to injury, death, mental harm, lack of development or deprivation. This study aimed to assess the prevalence of domestic violence agai...

  20. Role of Ultrasound in Male Infertility

    Energy Technology Data Exchange (ETDEWEB)

    Moon, Min Hoan; Sung, Chang Kyu [Dept. of Radiology, SMG-SNU Boramae Medical Center, Seoul National University College of Medicine, Seoul (Korea, Republic of)

    2012-06-15

    US evaluation is the mainstay of diagnostic imaging of infertile men. In this editorial, we review the spectrum of diseases responsible for male infertility, discuss the way in which US imaging studies can be used for evaluation of male infertility, and illustrate characteristic US imaging features that allow for specific diagnosis. The discussion will be divided into three main categories: obstruction in sperm passage, impairment of sperm function, and defect in sperm genesis.

  1. Bacterial vaginosis among women with tubal factor infertility in Nigeria.

    Science.gov (United States)

    Durugbo, Innocent I; Nyengidiki, Tamunomie K; Bassey, Goddy; Wariso, Kennedy T

    2015-11-01

    To determine the prevalence of bacterial vaginosis among women with tubal factor infertility. A cross-sectional prospective study of women with tubal factor infertility was conducted at a Nigerian teaching hospital between March and September 2014. An equal number of fertile women attending the family planning clinic were recruited as controls. Interviews were conducted to collect data on sociodemographic characteristics, history and characteristics of vaginal discharge, knowledge, and practices. Bacterial vaginosis was diagnosed using the Amsel criteria. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to determine predisposing factors. Overall, 178 women with tubal factor infertility were recruited. Bacterial vaginosis was noted in 50 (28.1%) of these women, compared with 14 (7.9%) of 178 fertile women (P vaginosis when they were of low socioeconomic class (OR 11.89; 95% CI 5.20-27.69), practiced vaginal douching (OR 19.15; 95% CI 7.26-47.75), used vaginal drying agents (OR 17.04; 95% CI 6.91-43.24), had an early sexual debut (OR 32.08; 95% CI 12.02-88.89), and had a history of sexually transmitted infections (OR 12.42; 95% CI 5.36-29.35). The prevalence of bacterial vaginosis was high among patients with tubal factor infertility. Socioeconomic and cultural factors contribute to the risk of the condition. Copyright © 2015 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

  2. Primary infertility associated with neuroendocrine tumor (Carcinoid) of the appendix

    Institute of Scientific and Technical Information of China (English)

    Brad B Swelstad; Paul R Brezina; Clark T Johnson; Nina Resetkova; Irene Woo; Lisa Kolp

    2012-01-01

    Neuroendocrine tumors of the appendix(NET-A), formerly called appendiceal carcinoids, are rare tumors of the gastrointestinal tract.Appendiceal tumors have also been associated with infertility. However, in many of these cases, significant abdominal pathology, specifically pseudomyxoma peritonei, was identified during definitive surgical intervention.A34-year-old nulligravid woman undergoing infertility evaluation presented to an academic tertiary care fertility center. An abnormal mass was identified on hysterosalpingogram andCT confirmed appendiceal mass. Surgical removal of the mass was performed and histopathology was consistent with anNET-A with negative margins extending to the serosa.Two months after surgical intervention, the patient spontaneously conceived pregnancy and subsequently delivered a normal infant.This case exemplifies the importance of careful inspection of radiologic films by the gynecologic physician. Of added interest, this case describes an asymptomaticNET-A associated with primary infertility. To our knowledge, this is the first report of an incidentally indentifiedNET-A that resulted in primary infertility.

  3. Sperm mitochondrial DNA deletion in Iranian infertiles with asthenozoospermia.

    Science.gov (United States)

    Bahrehmand Namaghi, I; Vaziri, H

    2017-04-01

    Asthenozoospermia is an important cause of male infertility. The mutations in sperm mitochondrial DNA (mtDNA) result in either functionless or malfunctioning some proteins, subsequently affecting sperm motility leading to asthenozoospermia. The purpose of this study was to investigate sperm mtDNA 4,977-bp deletion in infertile men with low sperm motility/immotile spermatozoa compared to healthy subjects with high sperm motility. Semen samples of 256 asthenozoospermic infertiles and 200 controls from northern Iran were collected. After extraction of spermatozoa total DNA, Gap-polymerase chain reaction (Gap-PCR) was performed. The deletion was observed in 85.93% of patients with asthenozoospermia compared with 14% in controls [OR = 37.5397, 95% confidence interval = 12.937-108.9276, p asthenozoospermia-induced infertility in the population examined. Large-scale mtDNA deletions in spermatozoa may induce bioenergetic disorders. Nevertheless, to validate our results broader research may be needed.

  4. Chromosomal Abnormalities in Infertile Men from Southern India.

    Science.gov (United States)

    Suganya, Jaganathan; Kujur, Smita B; Selvaraj, Kamala; Suruli, Muthiah S; Haripriya, Geetha; Samuel, Chandra R

    2015-07-01

    Male infertility has been associated with aneuploidies and structural chromosomal abnormalities, Yq microdeletions and specific gene mutations and/or polymorphisms. Besides genetic factors, any block in sperm delivery, endocrine disorders, testicular tumours, infectious diseases, medications, lifestyle factors and environmental toxins can also play a causative role. This study aimed to determine the constitutional karyotype in infertile males having normal female partners in a south Indian population. A total of 180 men with a complaint of primary infertility ranging from 1 to 25 years were screened for chromosomal abnormalities through conventional analysis of GTG-banded metaphases from cultured lymphocytes. Four individuals were diagnosed to have Klinefelter syndrome. Two cases exhibited reciprocal translocations and one showed a maternally inherited insertion. Polymorphisms were seen in sixty-seven patients (37.2%). The occurrence of chromosomal abnormalities in 4.6% and variants involving the heterochromatic regions of Y, chromosome 9 and the acrocentric chromosomes in 38.2% of the infertile men with an abnormal seminogram strongly reiterates the inclusion of routine cytogenetic testing and counselling in the diagnostic work-up prior to the use of assisted reproduction technologies.

  5. Mitochondrial Genetic Variation in Iranian Infertile Men with Varicocele

    Directory of Open Access Journals (Sweden)

    Mohammad Mehdi Heidari

    2016-09-01

    Full Text Available Background: Several recent studies have shown that mitochondrial DNA mutations lead to major disabilities and premature death in carriers. More than 150 mutations in human mitochondrial DNA (mtDNA genes have been associated with a wide spectrum of disorders. Varicocele, one of the causes of infertility in men wherein abnormal inflexion and distension of veins of the pampiniform plexus is observed within spermatic cord, can increase reactive oxygen species (ROS production in semen and cause oxidative stress and sperm dysfunction in patients. Given that mitochondria are the source of ROS production in cells, the aim of this study was to scan nine mitochondrial genes (MT-COX2, MT-tRNALys, MT-ATP8, MT-ATP6, MT-COX3, MT-tRNAGly, MT-ND3, MT-tRNAArg and MT-ND4L for mutations in infertile patients with varicocele. Materials and Methods: In this cross-sectional study, polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP and DNA sequencing were used to detect and identify point mutations respectively in 9 mitochondrial genes in 72 infertile men with varicocele and 159 fertile men. In brief, the samples showing altered electrophoretic patterns of DNA in the SSCP gel were sent for DNA sequencing to identify the exact nucleotide variation. Results: Ten type nucleotide variants were detected exclusively in mitochondrial DNA of infertile men. These include six novel nucleotide changes and four variants previously reported for other disorders. Conclusion: Mutations in mitochondrial genes may affect respiratory complexes in combination with environmental risk factors. Therefore these nucleotide variants probably lead to impaired ATP synthesis and mitochondrial function ultimately interfering with sperm motility and infertility.

  6. Mammographic breast density in infertile and parous women.

    Science.gov (United States)

    Letizia, Meggiorini Maria; Rita, Vestri Anna; Grazia, De Stefano Maria; Valentina, Cipolla; Filippo, Bellati; Diana, Maffucci; Paola, Nusiner Maria; Cesare, Aragona; Carlo, De Felice

    2016-02-09

    Mammographic breast density is a useful marker for breast cancer risk, as breast density is considered one of the strongest breast cancer risk factors. The study objective was to evaluate and compare mammographic breast density in infertile and parous women, as infertility may be associated with high breast density and cancer occurrence. This study evaluated mammographic breast density using two different systems, BIRADS and Boyd. A selected patient population of 151 women with primary infertility (case group) was compared to 154 parous women who had at least one previous pregnancy (control group). Both groups were premenopausal women aged ≥ 35. Evaluation of mammographic features showed that 66.9% of case group patients and 53.9% of control group patients were classified BIRADS-3/BIRADS-4; p BIRADS-3/BIRADS-4 was 1.78 (95% CI: 1.10-2.89). Using the Boyd classification system, 53.6% of case group patients and 31.8% of control group patients were classified E/F; p BIRADS classification systems indicate to what extend breast cancer lesions may be missed on mammography due to masking by dense tissue. Therefore, patients with a high BIRADS or Boyd score should undergo further investigation.

  7. Elevated antithyroid peroxidase antibodies indicating Hashimoto's thyroiditis are associated with the treatment response in infertile women with polycystic ovary syndrome.

    Science.gov (United States)

    Ott, Johannes; Aust, Stefanie; Kurz, Christine; Nouri, Kazem; Wirth, Stefan; Huber, Johannes C; Mayerhofer, Klaus

    2010-12-01

    In infertile women suffering from polycystic ovary syndrome (PCOS), anti-thyroid peroxidase antibodies values exceeding the upper level of normal were found in significantly more clomiphene citrate resistant patients compared clomiphene citrate responders and metformin responders. Thus, elevated antiTPO levels are associated with poor treatment response in infertile women who suffer from PCOS.

  8. Dropout is a problem in lifestyle intervention programs for overweight and obese infertile women : a systematic review

    NARCIS (Netherlands)

    Mutsaerts, M. A. Q.; Kuchenbecker, W. K. H.; Mol, B. W.; Land, J. A.; Hoek, A.

    2013-01-01

    What are the dropout rates in lifestyle intervention programs (LIPs) for overweight and obese infertile women and can intervention- or patient-related baseline factors associated with dropout be identified in these women? The median dropout rate was 24 in overweight and obese infertile women who par

  9. Missing Motherhood: Jordanian Women's Experiences with Infertility

    Directory of Open Access Journals (Sweden)

    Hala Mahmoud Obeidat

    2014-01-01

    Full Text Available Aim, Background, and Introduction. Bearing and rearing children are an important part of life in nearly all cultures and are a central role for Jordanian Muslim women. Infertility can create anxiety, stress, and depression for couples who are infertile. Women frequently bear the emotional stigma of a couple’s infertility. There is a paucity of literature focusing on Jordanian Muslim women experiencing infertility and failed assistive reproductive technology. Therefore, this study explored these women’s lived experience. Methods. Qualitative data were collected through interviews with 30 Jordanian Muslim women who experienced failed assistive reproductive technology for infertility. Perceptions of experiences with failed treatment of infertility were documented and analyzed. Results. Major themes were identified: missing out on motherhood and living with infertility, experiencing marital stressors, feeling social pressure, experiencing depression and disappointment, having treatment associated difficulties, appreciating support from family and friends, using coping strategies, and fear of an unknown future. Discussion, Conclusion, and Implications for Clinical Practice. Being infertile significantly influences the physical, emotional, social, and spiritual health of Jordanian Muslim women as well as their quality of life. Perceived social support and personal coping strategies were used by study participants to mediate failed attempts to conceive. Designing and implementing culturally appropriate interventions for Muslim women globally who are experiencing infertility are essential.

  10. Infertility trial outcomes: healthy moms and babies.

    Science.gov (United States)

    Silver, Robert

    2014-05-01

    Traditionally, the primary outcome of infertility trials has been a positive pregnancy test or a clinically recognized pregnancy. However, parents desire a healthy baby that grows up to be a healthy adult, rather than a positive pregnancy test. Too often results of infertility trials are lacking in crucial obstetric details. This is problematic because treatments for infertility have the capacity to increase the risk for a variety of adverse obstetric outcomes. This review will outline important obstetric variables that should be included when reporting infertility research. The rationale for including these data, precise definitions of the variables, and cost-effective strategies for obtaining these obstetric details will be highlighted.

  11. Mitochondrial DNA mutations and male infertility

    Directory of Open Access Journals (Sweden)

    Kumar D

    2009-01-01

    Full Text Available Infertility can be defined as difficulty in conceiving a child after 1 year of unprotected intercourse. Infertility can arise either because of the male factor or female factor or both. According to the current estimates, 15% of couples attempting their first pregnancy could not succeed. Infertility is either primary or secondary. Mitochondria have profound effect on all biochemical pathways, including the one that drivessperm motility. Sperm motility is heavily dependent on the ATP generated by oxidative phosphorylation in the mitochondrial sheath. In this review, the very positive role of mitochondrial genome′s association with infertility is discussed

  12. Role of female pelvic anatomy in infertility.

    Science.gov (United States)

    Harris-Glocker, Miranda; McLaren, Janet F

    2013-01-01

    Infertility is defined as a couple's failure to achieve pregnancy after one year of regular, unprotected intercourse. The etiology of infertility can be due to female factors, male factors, combined male and female factors, or have an unknown etiology. This review focuses on the role of female pelvic anatomy in infertility. Normal anatomy and the physiology of reproduction will be discussed, as well as the anatomic and pathophysiologic processes that cause infertility including ovulatory disorders, endometriosis, pelvic adhesions, tubal blockage, mullerian anomalies, and abnormalities affecting the uterine cavity such as leiomyomata and endometrial polyps.

  13. Serum Levels of Melatonin and Oxidative Stress Markers and Correlation between Them in Infertile Men

    Directory of Open Access Journals (Sweden)

    Sara Soleimani Rad

    2013-11-01

    Full Text Available Introduction: Infertility is the problem of 15% of young couples in different societies. One of the factors that could affect fertility is oxidative stress. Therefore, the aim of the present study is to investigate the level of Melatonin, a free radical scavenger, and its correlation with oxidative biomarkers in infertile men. Methods:For this purpose, fertile and infertile men in 2 groups, 30 people in each group, were studied. The fertile men were selected from husbands of patients admitted to Alzahra obstetric and gynecology hospital, according to WHO standards. The infertile men were selected from patients referred to infertility ward. Blood sampling from the participants carried out at a specific time, sera collected and the levels of malondialdehyde, total antioxidant capacity and Melatonin were detected in the sera. The data were analyzed using t-test and Sperman's correlation method. Results: Melatonin level in the sera from fertile men were 522 (39.32 ng/L and in infertile men were 511.78 (34.6 ng/L. MDA level in fertile and infertile men were 2.26 (0.34 vs 2.99 (0.44 nmol/ml which was significantly different. The level of TAC in the sera from fertile men were significantly higher than in infertile men. The result obtained for correlation coefficient Spearman's test revealed a significant, strong and direct correlation between Melatonin and TAC and a significant and reverse correlation between melatonin and MDA.Conclusion: It is concluded that melatonin could be involved in infertility. In other word, melatonin treatment and antioxidant-rich nutrition could help fertility by combating oxidative stress.

  14. Genetics Home Reference: CATSPER1-related nonsyndromic male infertility

    Science.gov (United States)

    ... related nonsyndromic male infertility CATSPER1-related nonsyndromic male infertility Enable Javascript to view the expand/collapse boxes. ... All Close All Description CATSPER1 -related nonsyndromic male infertility is a condition that affects the function of ...

  15. The influence of nursing intervention on obese patients with polycystic ovary syndrome combined with infertility%护理干预对肥胖型多囊卵巢综合征不孕患者的影响

    Institute of Scientific and Technical Information of China (English)

    黄李芸; 饶红超; 罗梅莲

    2014-01-01

    Objective To explore the nursing intervention on pregnancy rate and endocrine indexes in obese patients with polycystic ovary syndrome(PCOS)combined with infertility.Meth-ods 40 infertile patients with polycystic ovary syndrome were randomly divided into control group and observation group.Control group was given the therapy of medication induced ovulation while the observation group was given nursing intervention before treatment for four months in advance. The pregnancy rate and endocrine index were compared.Results The pregnancy rate in the ob-servation group was 45%(9 /20)which was significantly higher than 15%(3 /20)in the control group.The difference was statistical significant(P <0.05).Through nursing interventions,obesi-ty,polycystic ovary syndrome,infertility endocrine indexes including testosterone (T),luteinizing hormone (LH),LH /FSH and insulin resistance index (HOMA-IR)had changed compared with the condition before.The difference was significant.Conclusion The systematic nursing inter-vention is significant on polycystic ovary syndrome,particularly for obese women with polycystic o-vary syndrome.It could increase pregnancy rates,endocrine metabolism,lifestyle and mental health,so it is worthy of promotion.%目的:探讨护理干预对肥胖型多囊卵巢综合征不孕患者妊娠率、内分泌指标的影响。方法将40例多囊卵巢综合征不孕患者随机分为对照组和观察组,对照组仅采取药物促排卵治疗,观察组在药物治疗前给予4个月护理干预,观察比较2组的妊娠率、内分泌指数。结果观察组妊娠率为45%(9/20),显著高于对照组的15%(3/20),差异具有统计学意义(P <0.05);通过护理干预,肥胖型多囊卵巢综合征不孕患者内分泌指数包括睾酮(T)、黄体生成素(LH)、LH /FSH、胰岛素抵抗指数(HOMA-IR)较干预前有所变化,差异具有统计学意义(P <0.05)。结论系统的护理干预对多囊卵

  16. Chromosomal anomalies in infertile azoospermic and oligospermic men

    Directory of Open Access Journals (Sweden)

    Kalantari P

    2001-08-01

    Full Text Available In this study, chromosome analyses were performed on 70 infertile Azoospermic and Oligospermic (<20 million/ml men, and also cultures of peripheral blood lymphocytes by high resolution banding method were analysed as well. It is revealed 8 (11.43 percent men with chromosomal abnormality. There were 31.4 percent patients with azoospermia and 68.6 percent with oligospermia from several thousands to 20×10^6 million/ml and their duration of infertility was at least 2 years. All patients with numerical chromosome anomalies had azoospermia and the most frequent anomaly was 47, XXY chromosomal constitution (klinfelter's syndrome, found in 8.57 percent of patients. We found that chromosomal anomalies found in this study were sex chromosome anomalies and an increased rate of numerical chromosomal abnormalities was among men with azoospermia. As a conclusion, we suggest that all men with azoospermia be considered for cytogenetical evaluation. 

  17. Androgen receptor roles in spermatogenesis and infertility.

    Science.gov (United States)

    O'Hara, Laura; Smith, Lee B

    2015-08-01

    Androgens such as testosterone are steroid hormones essential for normal male reproductive development and function. Mutations of androgen receptors (AR) are often found in patients with disorders of male reproductive development, and milder mutations may be responsible for some cases of male infertility. Androgens exert their action through AR and its signalling in the testis is essential for spermatogenesis. AR is not expressed in the developing germ cell lineage so is thought to exert its effects through testicular Sertoli and peri-tubular myoid (PTM) cells. AR signalling in spermatogenesis has been investigated in rodent models where testosterone levels are chemically supressed or models with transgenic disruption of AR. These models have pinpointed the steps of spermatogenesis that require AR signalling, specifically maintenance of spermatogonial numbers, blood-testis barrier integrity, completion of meiosis, adhesion of spermatids and spermiation, together these studies detail the essential nature of androgens in the promotion of male fertility.

  18. Embryo splitting: a role in infertility?

    Science.gov (United States)

    Wood, C

    2001-01-01

    Embryo splitting may be used to increase the potential fertility of couples requiring IVF. Using cattle as a model, it is possible to increase pregnancy rates from 70% per transfer of good quality in-vivo-produced embryos, to 110% by transferring the two demi-embryos resulting from the bisection of one embryo. The 30-40% greater chance of conception would reduce costs for the government, health authorities and patients, and reduce stress, time and complications for women having IVF treatment. Embryo splitting may also provide donor embryos for infertile couples that cannot conceive naturally or with IVF. The shortage of children for adoption and donor embryos may be overcome by the production of demi-embryos.

  19. Genetic variants in TP53 and MDM2 associated with male infertility in Chinese population

    Institute of Scientific and Technical Information of China (English)

    Cong Huang; Wei Liu; Gui-Xiang Ji; Ai-Hua Gu; Jian-Hua Qu; Ling Song; Xin-Ru Wang

    2012-01-01

    The TP53,a transcriptional regulator and tumor suppressor,is functionally important in spermatogenesis.MDM2 is a key regulator of the p53 pathway and modulates p53 activity.Both proteins have been functionally linked to germ cell apoptosis,which may affect human infertility,but very little is known on how common polymorphisms in these genes may influence germ cell apoptosis and the risk of male infertility.Thus,this study was designed to test whether three previously described polymorphisms 72Arg>Pro (rs1042522) and the Ex2+ 19C>T (rs2287498) in TP53,and the 5' untranslated region (5' UTR) 309T>G (rs937283) in MDM2,are associated with idiopathic male infertility in a Chinese population.The three polymorphisms were genotyped using OpenArray assay in a hospital-based case-control study,including 580 infertile patients and 580 fertile controls.Our analyses revealed that TP53 Ex2+ 19C>T and MDM2309T>G polymorphisms are associated with mate infertility.Furthermore,we detected a nearly statistically significant additive interaction between TP53 rs2287498 and MDM2 rs937283 for the development of male.infertility (Pinteraction=0.055).In summary,this study found preliminary evidence,demonstrating that genetic variants in genes of the TP53 pathway are risk factors for male infertility.

  20. Prevalence of Ureaplasma and Mycoplasma in Infertile Men in Van Region and Effects to Semen Parameters

    Directory of Open Access Journals (Sweden)

    Kerem Taken

    2016-01-01

    Full Text Available Aim: The purpose of this study was to assess the prevalence of Ureaplasma urealyticum (UU and Mycoplasma hominis (MH in semen cultures of cases with primary infertility in the Van Province, and also to determine the effect of therapy on sperm parameters. Material and Method: The study included 106 individuals divided into three groups: The infertile group (41 cases, the group with lower urinary tract symptoms (33 cases, and the control group (32 cases. The patients in the infertile group had no history of varicocele, testicular torsion, hydrocele, undescended testis, and hormonal disorders. The control group included cases without infertility and lower urinary tract symptoms. The parameters of culture-positive cases in the infertile group were determined before and after therapy. The identification of Mycoplasma species was made using the Biomerieux® Mycoplasma IST 2 (RCS Lyon-France kit. The sperm count was carried out with the Makler counting chamber (Self Medical Industries, Haifa, Israel. Results: In the infertile group, UU was isolated from 17 and MH was isolated from 3 cases. In the group with lower urinary tract symptoms, UU was isolated from 15 (45.5% and MH was isolated from 6 (18.8% cases. In the control group, UU was isolated from 6 (18.8% cases, but MH was isolated from none of the cases. In the infertile group, the sperm counts in 3 culture-positive cases (15% and in 10 culture-negative cases (50% were

  1. Role of genetic mutations in folate-related enzyme genes on Male Infertility

    Science.gov (United States)

    Liu, Kang; Zhao, Ruizhe; Shen, Min; Ye, Jiaxin; Li, Xiao; Huang, Yuan; Hua, Lixin; Wang, Zengjun; Li, Jie

    2015-01-01

    Several studies showed that the genetic mutations in the folate-related enzyme genes might be associated with male infertility; however, the results were still inconsistent. We performed a meta-analysis with trial sequential analysis to investigate the associations between the MTHFR C677T, MTHFR A1298C, MTR A2756G, MTRR A66G mutations and the MTHFR haplotype with the risk of male infertility. Overall, a total of 37 studies were selected. Our meta-analysis showed that the MTHFR C677T mutation was a risk factor for male infertility in both azoospermia and oligoasthenoteratozoospermia patients, especially in Asian population. Men carrying the MTHFR TC haplotype were most liable to suffer infertility while those with CC haplotype had lowest risk. On the other hand, the MTHFR A1298C mutation was not related to male infertility. MTR A2756G and MTRR A66G were potential candidates in the pathogenesis of male infertility, but more case-control studies were required to avoid false-positive outcomes. All of these results were confirmed by the trial sequential analysis. Finally, our meta-analysis with trial sequential analysis proved that the genetic mutations in the folate-related enzyme genes played a significant role in male infertility. PMID:26549413

  2. Chromosomal abnormalities in infertile men referred to iran blood transfusion organization research center.

    Science.gov (United States)

    Frouzandeh, Mahjoubi; Saeideh, Soleimani; Sanaz, Mantegy

    2010-10-01

    The prevalence of somatic chromosomal abnormalities in infertile male individuals has been reported to vary in different literatures. The aim of this study was to investigate the frequency of chromosomal aberrations among infertile men referred to the Cytogenetic Laboratory of Iran Blood Transfusion Organization Research Centre (IBTO). Chromosomal analysis was performed on phytohemag-glutinin (PHA)-stimulated peripheral lymphocyte cultures of 1052 infertile men using standard cytogenetic methods. The study took place during 1997 to 2007. Total chromosome alterations were revealed in 161 (15.30%) infertile men. The most prevalent chromosomal abnormality in the infertile men was 47, XXY, that was seen in 94 (58.38%) men while one of them had a mosaic karyotype: mos 47, XX[54]/47,XXY[18]/46,XY[9]. In 37 (22.98%) cases, structural aberrations were detected. There were 30 (18.63%) cases of sex reversal. Cytogenetic studies of these patients showed increased chromosomal abnormalities in infertile men in comparison with that of the normal population, justifying the need for cytogenetic analysis of men with idiopathic infertility.

  3. Association of polymorphism in cell death pathway gene FASLG withhuman male infertility

    Institute of Scientific and Technical Information of China (English)

    Deepika Jaiswal; Sameer Trivedi; Neeraj K Agrawal; Kiran Singh

    2015-01-01

    Objective: To investigate –844C>T single nucleotide polymorphism (SNP) present in the promoter of cell death pathway gene FASLG with male infertile phenotype. Methods:Genotyping for SNP FASLG (rs763110) was done by polymerase chain reaction followed by analysis with specific endonuclease (PCR-RFLP). DNA sequencing was used to ascertain PCR-RFLP results. Results: FASLG –844C>T polymorphism, allele and genotype distribution did not differ significantly between patients and controls (OR: 1.03, 95% CI= 0.7638 to 1.3952, P=0.83). Thus SNP-844C>T of the FASLG gene is not associated with male infertility risk in the analyzed patients. Conclusion: Human male infertility is a complex disorder and thus other genetic or environmental factors may be contributing to the complex etiology, and further study in other region of Indian populations will verify whether it is associated with male infertility risk.

  4. Clinical, genetic, biochemical, and testicular biopsy findings among 1,213 men evaluated for infertility

    DEFF Research Database (Denmark)

    Olesen, Inge Ahlmann; Andersson, Anna-Maria; Aksglaede, Lise

    2017-01-01

    OBJECTIVE: To study the pathologic findings among men evaluated for infertility. DESIGN: A retrospective, single-center, cross-sectional study. SETTING: University hospital-based research center. PARTICIPANT(S): We included data from 1,213 medical records from infertile men referred for diagnostic...... work-up from 2005 to 2009. INTERVENTIONS(S): None. MAIN OUTCOME MEASURE(S): Health history, clinical findings, chromosome/genetic aberrations, semen quality, reproductive hormones. RESULT(S): In total, 64.4% of the infertile men had one or more reproductive disorders or factors influencing fertility......, leaving 35.6% diagnosed as idiopathic infertile. In 244 patients (20%), including seven cases of testicular cancer and/or germ cell neoplasia in situ, a pathologic finding was first detected during diagnostic work-up. Two hundred four patients (16.8%) had a history of cryptorchidism and 154 (12...

  5. Mood disorders, psychiatric symptoms, and distress in women presenting for infertility evaluation.

    Science.gov (United States)

    Downey, J; Yingling, S; McKinney, M; Husami, N; Jewelewicz, R; Maidman, J

    1989-09-01

    Women who undergo treatment for infertility frequently report depression, but it is crucial to distinguish between subjective distress, symptoms, and clinical depressive disorders. In the initial assessment of a prospective, longitudinal study, 59 women presenting for infertility treatment were compared with 35 women presenting for routine gynecological care. Infertility patients and controls were not significantly different on self-report measures of partner satisfaction, sexual functioning, or self-esteem. There was also no difference in psychiatric symptomatology, or in the percentage of subjects who were currently experiencing or had ever experienced a major depressive episode. However, the infertility patients perceived themselves to have been already quite affected by their inability to conceive. For instance, 49.2% reported changes in their sexual functioning and 74.6% reported changes in their mood.

  6. Comparison of reproductive outcome in oligozoospermic men with high sperm DNA fragmentation undergoing intracytoplasmic sperm injection with ejaculated and testicular sperm.

    Science.gov (United States)

    Esteves, Sandro C; Sánchez-Martín, Fernando; Sánchez-Martín, Pascual; Schneider, Danielle T; Gosálvez, Jaime

    2015-12-01

    To investigate the effectiveness of intracytoplasmic sperm injection (ICSI) using testicular sperm as a strategy to overcome infertility in men with high sperm DNA fragmentation (SDF). Prospective, observational, cohort study. Private IVF centers. A total of 147 couples undergoing IVF-ICSI and day 3 fresh ETs whose male partner has oligozoospermia and high SDF. Sperm injections were carried out with ejaculated sperm (EJA-ICSI) or testicular sperm (TESTI-ICSI) retrieved by either testicular sperm extraction (TESE) or testicular sperm aspiration (TESA). SDF levels were reassessed on the day of oocyte retrieval in both ejaculated and testicular specimens. Percentage of testicular and ejaculated spermatozoa containing fragmented DNA (%DFI) and clinical pregnancy, miscarriage, and live-birth rates. The %DFI in testicular sperm was 8.3%, compared with 40.7% in ejaculated sperm. For the TESTI-ICSI group versus the EJA-ICSI group, respectively, the clinical pregnancy rate was 51.9% and 40.2%, the miscarriage rate was 10.0% and 34.3%, and the live-birth rate was 46.7% and 26.4%. ICSI outcomes were significantly better in the group of men who had testicular sperm used for ICSI compared with those with ejaculated sperm. SDF was significantly lower in testicular specimens compared with ejaculated counterparts. Our results suggest that TESTI-ICSI is an effective option to overcome infertility when applied to selected men with oligozoospermia and high ejaculated SDF levels. Copyright © 2015 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  7. The relationship of γH2AH and sperm DNA damage in male infertility patients%γH2AX与男性不育患者精子DNA 损伤的关系及意义

    Institute of Scientific and Technical Information of China (English)

    钟慧芝; 吕福通; 谢丹尼; 莫毅; 林发全

    2015-01-01

    目的:研究γH2AX在男性不育患者精液中的表达水平,探讨γH2AX用于评价男性不育患者精子DNA双链断裂(DSBs)损伤程度的可行性。方法选取就诊于广西医科大学第一附属医院生殖医学研究中心、男性科门诊并确诊为男性不育患者27例(男性不育组),另外选取23例确认有生育能力的健康男性的精液样本作为对照组。通过 PureSperm 密度梯度离心法(DGC)优选精子,运用单向凝胶电泳技术(SCGE)和流式细胞术方法对健康男性、男性不育组患者的精液进行精子双链DNA损伤和γH2AX含量的测定和比较。结果男性不育组患者精子DSBs损伤程度和γH2AX表达含量均高于对照组(P<0.01),而经密度梯度离心法优选精子后,两组男性精子的DSBs损伤程度和γH2AX表达含量均显著下降(P<0.01)。结论γH2AX在男性不育患者精子中的含量明显高于健康男性,可作为检测精子DNA双链断裂损伤程度的一个新的标志物。%Objective To investigate whether γH2AX could be a useful biomarker for evaluating the DNA double‐stranded . Methods Semem samples in case group were from 27 infertile males who were diagnosed in Andriatrics department or reproductive centre in the First Affiliated Hospital of Guangxi Medical University .The other semen samples were from 23 healthy donors with fertility as comparison .The levels of γH2AX were detected by flow cytometry .Single cell gel electropherosis(SCGE)was applied to assess the level of DSBs of sperm .Density gradient centrifugation(DGC) was applied to optimized spermatozoa .Results TheγH2AX levels and the DSBs of the sperm of the infertile subjects were significantly higher than those of healthy males(P<0 .01) , and the levels of γH2AX and the DSBs of sperm significantly decreased in two groups by DGC(P<0 .01) .Conclusion The level of spermatozoaγH2AX is higher in male infertility patients than in healthy

  8. Epigenetics, spermatogenesis and male infertility.

    Science.gov (United States)

    Rajender, Singh; Avery, Kelsey; Agarwal, Ashok

    2011-01-01

    Epigenetic modifications characterized by DNA methylation, histone modifications, and chromatin remodeling are important regulators in a number of biological processes, including spermatogenesis. Several genes in the testes are regulated through epigenetic mechanisms, indicating a direct influence of epigenetic mechanisms on the process of spermatogenesis. In the present article, we have provided a comprehensive review of the epigenetic processes in the testes, correlation of epigenetic aberrations with male infertility, impact of environmental factors on the epigenome and male fertility, and significance of epigenetic changes/aberrations in assisted reproduction. The literature review suggested a significant impact of epigenetic aberrations (epimutations) on spermatogenesis, and this could lead to male infertility. Epimutations (often hypermethylation) in several genes, namely MTHFR, PAX8, NTF3, SFN, HRAS, JHM2DA, IGF2, H19, RASGRF1, GTL2, PLAG1, D1RAS3, MEST, KCNQ1, LIT1, and SNRPN, have been reported in association with poor semen parameters or male infertility. Environmental toxins/drugs may affect fertility via epigenetic modifications. For example, 5-aza-2'-deoxycytidine, an anticancer agent, causes a decrease in global DNA methylation that leads to altered sperm morphology, decreased sperm motility, decreased fertilization capacity, and decreased embryo survival. Similarly, Endocrine disruptors, such as methoxychlor (an estrogenic pesticide) and vinclozolin (an anti-androgenic fungicide) have been found by experiments on animals to affect epigenetic modifications that may cause spermatogenic defects in subsequent generations. Assisted reproduction procedures that have been considered rather safe, are now being implicated in inducing epigenetic changes that could affect fertility in subsequent generations. Techniques such as intracytoplasmic sperm injection (ICSI) and round spermatid injection (ROSI) may increase the incidence of imprinting disorders and

  9. 卵巢早衰性不孕症预后及妊娠结局研究%Studyof prognosis and pregnancy outcome for infertility patients with premature ovarian

    Institute of Scientific and Technical Information of China (English)

    周雪梅; 辛亚兰; 袁丽萍; 王霞; 吴羽; 廖芸

    2015-01-01

    Objectives:To investigate the related etiology factors,prognosis and the effect on pregnancy for infertility patients with premature ovarian failure (POF).Methods:42 infertility patients with POF were selected as study objects (POF group),and 60 patients with tubal infertility were collected as control (control group).The re-lated pathogenesis factors,clinical prognosis and pregnancy outcome of two groups was analyzed.Results:In POF group,all patients had menopause history,with fewer gravidity number on average than the control group (P 0.05).In POF group,the hor-mone levels of FSH,LH and E,the volume of uterine and bilateral ovarian,and the count of antral follicle was sig-nificantly different from those in the control group (P 0.05).After 1 years of treatment,both menstrual cycle recovery rate and self -conscious symptom improvement rate in POF group were over 95%,while FSH,E,LH,volume of uterus and ovarian,antral follicle also improved continually,however,the compliance rate of clinical indicators on ovarian function was still low.Two groups were followed up for 2 years.The natural pregnancy rate of POF group was 7.4% (3 /42)with 4.8% assis-ted reproductive rate and 4.8% carried infant rate;while in control group,the natural pregnancy rate was 25%(15 /60),assisted reproductive rate was 28.3%,with 38.3%(23 /60)carried infant rate;the difference in natural pregnancy rate,assisted reproductive rate and carried infant rate between the two groups was statistically significant (P <0.05).Conclusion:The etiology of infertility with premature ovarian failure is complex,relevant to various factors.The treatment effect is poor,with low recovery rate of ovarian function,and the pregnancy rate and carried infant rate after treatment is also low.Therefore,it is important to strengthen prevention,early diagnosis and early treatment for POF.%目的:探讨卵巢早衰(POF)性不孕症的发病相关因素、预后及其对妊娠结局的影响。方法:以42例卵巢早

  10. CFTR M470V detection in male infertility patients%中国男性不育患者CFTR基因M470V检测及其意义

    Institute of Scientific and Technical Information of China (English)

    杜强; 邹宝林; 潘永峰; 李铮; 宋永胜; 吴斌

    2013-01-01

    目的:明确我国生育力正常男性人群和男性不育人群中的CFTR基因M470V多态性分布情况,以探讨CFTR基因M470V多态性改变与男性不育之间的关系.方法:知情同意的情况下收集临床诊断明确的非梗阻性无精子症患者67例、先天性双侧输精管缺如患者95例,以及因女方因素拟行试管婴儿助孕、精液常规检查正常的男性135例.外周血基因组DNA抽提,应用Cycling probe法检测M470V SNP类型,应用SPSS 13.0进行数据分析,使用卡方检验,P<0.05视为有显著性差异.结果:三组比较(生育力正常男性人群与先天性双侧输精管缺如患者以及非梗阻性无精子症患者)CFTR基因M470V基因型和等位基因分布频率无统计学差异(P值分别为0.4221和0.1794,P>0.05).MV基因型为最常见的基因型,在生育力正常男性人群中的基因型频率为0.4296,其次为VV基因型,基因型频率为0.3704,最少见的为MM基因型,基因型频率为0.2.MM、MV、VV基因型在生育力正常男性人群中的分布符合哈迪-温伯格平衡定律(χ2=1.7871,P=0.1813,P>0.05).V470等位基因为生育力正常男性人群中最常见的等位基因,其等位基因频率为0.5852,M470等位基因与V470等位基因在生育能力正常的男性人群中的分布比例约为0.7∶1,相比欧洲白种人(1∶1)偏低.结论:中国CFTR基因M470V多态性改变本身与患者罹患先天性双侧输精管缺如或非梗阻性无精子症无关.M/M、M/V、V/V基因型在中国生育力正常男性人群中的分布符合哈迪-温伯格平衡定律,M470与V470的分布比例约为0.7∶1.%Objectives: To confirm the distribution of M470V polymorphism in normal male and infertile male in order to probe the etiology of infertile Chinese male. Methods:With the patients ' permission, we collected 67 non - obstructive azoospermia patients, 95 congenital bilateral absence of the vas deferens patients and 135 patients whose semen was normal but try in

  11. Is Infertility Associated with Childhood Autism?

    Science.gov (United States)

    Grether, Judith K.; Qian, Yinge; Croughan, Mary S.; Wu, Yvonne W.; Schembri, Michael; Camarano, Loretta; Croen, Lisa A.

    2013-01-01

    Concerns persist about a possible link between infertility and risk of autism spectrum disorders (ASD). Interpretation of existing studies is limited by racial/ethnic homogeneity of study populations and other factors. Using a case-control design, we evaluated infertility history and treatment documented in medical records of members of Kaiser…

  12. Genes Causing Male Infertility in Humans

    Institute of Scientific and Technical Information of China (English)

    Lawrence C. Layman

    2002-01-01

    There are an accumulating number of identified gene mutations that cause infertility in humans. Most of the known gene mutations impair normal puberty and subsequently cause infertility by either hypothalamic /pituitary deficiency of important tropic factors to the gonad or by gonadal genes.

  13. Is Infertility Associated with Childhood Autism?

    Science.gov (United States)

    Grether, Judith K.; Qian, Yinge; Croughan, Mary S.; Wu, Yvonne W.; Schembri, Michael; Camarano, Loretta; Croen, Lisa A.

    2013-01-01

    Concerns persist about a possible link between infertility and risk of autism spectrum disorders (ASD). Interpretation of existing studies is limited by racial/ethnic homogeneity of study populations and other factors. Using a case-control design, we evaluated infertility history and treatment documented in medical records of members of Kaiser…

  14. Effect of the Modern Life on Infertility

    Directory of Open Access Journals (Sweden)

    Keziban Amanak

    2014-08-01

    Full Text Available Infertility is defined as failing to become pregnant at the end of one year although unprotected sexual intercourse of the couples. Infertility affects 15 % of couples at the reproductive age according to data of the World Health Organization. It was stated that approximately 1,5-2 million individuals in our country face infertility problem and problem increases gradually. One of the most important factors of increasing infertility problem is the adverse effects of modern life on our existence. Adverse effects of modern life are the common problems of the whole World. Postponement of gestational age as the result of modern life, obesity, electromagnetic waves, hormone-injected and genetically modified foodstuffs, stress, smoking and using alcohol, sexually transmitted diseases are among the increasing infertility causes. Adverse effects of the modern life on infertility may be minimized if the midwives and nurses know the harmful effects of modern life on infertility and provide consultancy services to couples, wishing to have a child. Effects of modern life on infertility and consultancy role of the midwives-nurses are discussed in this article. [TAF Prev Med Bull 2014; 13(4.000: 345-350

  15. The CAG repeat polymorphism of mitochondrial polymerase gamma (POLG) is associated with male infertility in Tunisia.

    Science.gov (United States)

    Baklouti-Gargouri, S; Ghorbel, M; Chakroun, N; Sellami, A; Fakhfakh, F; Ammar-Keskes, L

    2012-05-01

    Male fertility largely depends on sperm quality, which may be affected by environmental and genetic factors. Recent data emphasised the implication of the polymorphism of mitochondrial DNA polymerase gamma (POLG) CAG repeats in male infertility. In this report, we explored a possible role of the (POLG) gene polymorphism in male infertility in Tunisian men. The polymorphic CAG repeat in the nuclear POLG gene was studied in 339 male subjects (216 patients with infertility (69 azoospermic, 115 oligoasthenoteratospermic and 32 normospermic) and 123 fertile) after DNA amplification by PCR, followed by genotyping using an automatic sequencer. The heterozygous and the homozygous mutant genotypes (10/ ≠ 10 and ≠ 10/ ≠ 10) were significantly more frequent among infertile patients than among fertile controls (11.2% versus 1.6%, P = 1.3 × 10(-3) and 4.6% versus 0.8%, P = 4.2 × 10(-7) respectively). We also found a significant difference between the frequencies of 10/ ≠ 10 genotype in azoospermic (4.4%) and in oligoasthenoteratospermic (15.6%) infertile patients (P = 2.6 × 10(-2) ). However, the homozygous mutant genotype (≠ 10/ ≠ 10) was seen at similar frequencies in azoospermic, normospermic and oligoasthenospermic men (4.4%, 3.1% and 5.2% respectively). Under our conditions, the findings showed an association between POLG CAG repeat polymorphism and male infertility in Tunisian population.

  16. Single nucleotide polymorphisms of the heat shock protein 90 gene in varicocele-associated infertility

    Directory of Open Access Journals (Sweden)

    Pericles A. Hassun Filho

    2005-06-01

    Full Text Available PURPOSE: Varicoceles are associated with impaired testicular function and male infertility, but the molecular mechanisms by which fertility is affected have not been satisfactorily explained. Spermatogenesis might be affected by increased scrotal temperature, such as that caused by varicocele. HSP90 is a molecular chaperone expressed in germ cells and is related to spermatogenesis, motility, and both heat and oxidative stress. Possible correlations between coding single region nucleotide polymorphisms (cSNPs in the HSP90 gene in patients with varicocele associated with infertility were analyzed, and polymorphisms in these exons were characterized through DNA sequencing. MATERIALS AND METHODS: PCR-SSCP and DNA sequencing were used to search for mutations in 18 infertile patients with varicocele, 11 patients with idiopathic infertility and 12 fertile men. DNA was extracted from leucocytes for PCR amplification and SSCP analysis. DNA from samples with an altered band pattern in the SSCP was then sequenced to search for polymorphisms. RESULTS: Three silent polymorphisms that do not lead to amino acid substitutions were identified. CONCLUSION: Mutations in the HSP90 gene do not appear to be a common cause of male factor infertility. The low incidence of gene variation, or SNPs, in infertile men demonstrates that this gene is highly conserved and thus confirms its key role in spermatogenesis and response to heat stress.

  17. Chromosomal abnormalities and y chromosome microdeletions in infertile men with varicocele and idiopathic infertility of South Indian origin

    National Research Council Canada - National Science Library

    Rao, Lakshmi; Babu, Arvind; Kanakavalli, Murthy; Padmalatha, Venkata; Singh, Amarpal; Singh, Prashant Kumar; Deenadayal, Mamata; Singh, Lalji

    2004-01-01

    .... The objective of our present study was to investigate the chromosomal abnormalities and Y chromosome microdeletions in infertile men of South Indian origin with varicocele and idiopathic infertility...

  18. 接受辅助生殖技术治疗患者的心理健康状况及其心理干预措施的研究进展%Psychological survey and psychological interventions in infertility patients with assisted reproductive ;technology

    Institute of Scientific and Technical Information of China (English)

    赵冰玲; 韦立红; 韦继红

    2016-01-01

    In recent years,assisted reproductive technology (ART)is one of the most effective methods to treat infertility. Infertility patients have severe psychological problems at different treatment stages.Researches showed that the success of ART treatment,not only related with the patient′s own pathology and physiology,but also related with the patient′s psychological pressure during the treatment.The clinical successful pregnancy rate is associated with mental health,so psychological intervention during ART process is very important for infertility patients and medical staff.More attention about psychological interventions and education should be paid to infertility patients with ART.%目前,辅助生殖技术(ART)是治疗不孕不育最有效的方法。不孕不育患者在接受 ART治疗的不同阶段均面临不同的心理压力。接受 ART 治疗患者的临床成功妊娠率与其心理健康水平相关,若心理压力过大,可降低妊娠率和成功分娩率。因此,对接受 ART 治疗患者的心理干预,是ART 治疗过程中重要的组成部分。笔者拟对接受 ART 治疗患者的心理健康状况及其心理干预措施的研究进展进行综述。

  19. Male infertility in spinal cord trauma

    Directory of Open Access Journals (Sweden)

    Cristiano Utida

    2005-08-01

    Full Text Available Every year there are 10 thousand new cases of patients victimized by spinal cord trauma (SCT in the United States and it is estimated that there are 7 thousand new cases in Brazil. Eighty percent of patients are fertile males. Infertility in this patient group is due to 3 main factors resulting from spinal cord lesions: erectile dysfunction, ejaculatory disorder and low sperm counts. Erectile dysfunction has been successfully treated with oral and injectable medications, use of vacuum devices and penile prosthesis implants. The technological improvement in penile vibratory stimulation devices (PVS and rectal probe electro-ejaculation (RPE has made such procedures safer and accessible to patients with ejaculatory dysfunction. Despite the normal number of spermatozoa found in semen of spinal cord-injured patients, their motility is abnormal. This change does not seem to be related to changes in scrotal thermal regulation, frequency of ejaculation or duration of spinal cord damage but to factors related to the seminal plasma. Despite the poor seminal quality, increasingly more men with SCT have become fathers through techniques ranging from simple homologous insemination to sophisticated assisted reproduction techniques such as intracytoplasmic sperm injection (ICSI.

  20. STUDY OF GENITAL TUBERCULOSIS IN INFERTILE WOMEN

    Directory of Open Access Journals (Sweden)

    Shrikant

    2016-06-01

    Full Text Available AIM To determine the incidence of female Genital Tuberculosis (GTB and to analyse clinicopathological features for GTB and comparison of Polymerase Chain Reaction (PCR, Acid Fast Bacillus (AFB staining and Histopathology (HPR. STUDY SETTING A prospective study conducted on 50 infertile patients in the Department of Obstetrics and Gynaecology at Krishna Hospital, Karad, for a period of 2 years between December 2013 and December 2015. METHODS Patients were investigated for the presence of Mycobacterium Tuberculosis (MTB on samples collected by endometrial curettage by PCR, AFB and HPR. Additional tests like Hysterosalpingography (HSG Laparoscopic chromopertubation and hysteroscopy were performed if not done earlier. RESULT PCR demonstrated MTB DNA in 9 patients, and 2 were positive with AFB and HPR. Within positive patients HSG findings were suggestive of TB in 3 cases and laparoscopy in 5 cases and hysteroscopy in 4 cases. Two MTB PCR positive patients conceived spontaneously after 6 months of anti-tubercular treatment. CONCLUSION Genital tuberculosis is a diagnostic challenge if untreated it is chronic, progressive and destructive disease. Early diagnosis is crucial because once the infection damages the tubes, reverting tubal patency is very difficult. Molecular tests like DNA PCR have enabled us to detect the organism in its latent stage and initiation of treatment early in the disease can prevent many irreversible changes in the female genital tract.

  1. Patients’ Knowledge about Causes and Solutions of Infertility in South West Nigeria

    Directory of Open Access Journals (Sweden)

    Olukunmi ‘Lanre OLAITAN

    2012-07-01

    Full Text Available Background: Infertility inability to conceive after exposure to continuous unprotected sex for twelve months, is a major cause of marriage conflict in south west Nigeria. Knowledge of causes and solutions to infertility among selected patients were assessed in 18 hospital/fertility centre across the 6 states in south west geo-political zone of Nigeria. Aims and objectives: To assess the knowledge of patients about causes and solutions to infertility in south west Nigeria. Methods/study Design: A survey of a consecutive sample of 390 cases of infertility were carried out in 18 hospital/fertility centers with a total of 65 cases of infertility evaluated in each of the 6 States centers between 2009 – 2012. Chi-square statistics was employed to test the hypotheses formulated at α=0.05 level of significance. Results/Findings: The knowledge of causes and solutions to infertility in the patients were established in all the States; (Lagos, Ogun, Oyo, Osun, Ondo and Ekiti. The commonest causes of infertility among these patients were, RTIs, damaged fallopian tubes, anovulation, poor semen analysis, distorted uterus. Low libido, previous use of IUCDs and uterine fibroids representing 81%, 70%, 68.7%, 65.9%, 65.9%, 65.7%, 65.3% and 62% respectively. The least common causes were taking of psychoactive drugs and working in hot condition/wearing of tight underclothing which was seen in 33.7% and 38.5% of the patients respectively. The patients also have knowledge about solutions of infertility in this order, that ART, regular sexual intercourse, taking hormonal drugs, antibiotics of choice, multivitamins and surgical removal of fibroids as follows; 72.3%, 69.2% 69%, 66.9%, 65.4% and 64.6% respectively. However, the least common solutions according to the patients are seen thus; engaging in varieties of sexual styles/positions, adoption of a child, corrective tubal surgery and wearing of loose/free underclothing representing 25.1%, 33.6%, 33.8% and 35

  2. Relationship between semen routine parameters with reproductive hormones in male infertile patients%男性不育患者精液常规参数与生殖激素的关系

    Institute of Scientific and Technical Information of China (English)

    文春蓉; 杨鹏

    2016-01-01

    目的:对男性不育患者进行精液常规检查和血清生殖激素检测,探讨二者之间的关系及其对男性不育的影响。方法选取2014年6月至2015年2月在该院门诊就诊的42例不育男性作为研究对象,根据精液常规检查中精子密度和精子活力指标将其分为弱精子组(20例)和无精子组(22例),同时选取已生育、精液常规检查结果正常的17例男性作为对照组,测定三组研究对象5项生殖激素,包括卵泡刺激素(FSH)、黄体生成素(LH)、泌乳素(PRL)、雌二醇(E2)和睾酮(T)水平,并分别进行比较。结果弱精子组与对照组5项生殖激素水平比较,差异均无统计学意义(P>0.05);无精子组与对照组血清FSH、LH水平比较,差异均有统计学意义(P<0.05),但PRL、E2、T水平比较,差异均无统计学意义(P>0.05);无精子组与弱精子组血清FSH、LH水平比较,差异均有统计学意义(P<0.05),而PRL、E2、T水平比较,差异均无统计学意义(P>0.05)。结论男性不育患者同时进行精液常规检查和生殖激素检测很有必要,可以为病因分析和临床诊治及预后判断提供重要依据。%Objective To perform the semen routine and serum reproductive hormones detection in male infertile pa-tients and to investigate their relation and influence on male infertility. Methods Forty-two patients with male infertility in the outpatients department of our hospital from June 2014 to February 2015 were selected as the research subjects and divided into asthenospermia(20 cases) group and the azoospermia group(22 cases) according to the indicators of sperm density and sperm motility. At the same time 17 males with fertility and normal semen routine results were selected as the control group. The 5 repro-ductive hormones of follicle stimulating hormone (FSH),luteinizing hormone (LH),prolactin (PRL),estradiol (E2) and testos

  3. 排卵障碍性不孕症病人的人格特征与心理研究%Analysis of personality traits and psychological status of patients with anovulatory infertility

    Institute of Scientific and Technical Information of China (English)

    徐桂华; 王秋琴; 柏亚妹; 金胜姬; 何贵蓉

    2015-01-01

    Objective:To know about the psychological state and personality traits and their relations of patients with anovulatory infertility,and so as to provide evidences for making scientific,reasonable and effective inter-ventions in our country.Methods:The random sampling was used to choose 1 6 5 cases of infertile out patients from reproduction unit in TCM hospital in Jiangsu province from January to October in 2013.The self made questionnaire was used to collect basic data of patients,16PF was used to evaluate patients’personality traits, and SCL 90 was used to evaluate their psychological status.The collected data was analyzed and compared by SPSS 18.0.Results:Factors A、E、H、M、N、O and Q4 of patients’personality traits are significantly higher than norm,while B、C、F、Q1 and Q2 are lower(P<0.05).Total score of SCL 90 before and after showed an overall downward trend from the 1st to 6th month in our investigation(F=5.88,P=0.003).In the first month of this research,all factors were significantly higher than norm except the terror factor(P<0.05).Obsessive com-pulsive,depression,hostility factors are positive before ovulation,while sensitivity,depression,hostility are pos-itive after ovulation.In the sixth month,the anxiety factor is higher than the norm before ovulation while the depression factor after(P<0.05).Somatization symptom,obsessive compulsive symptoms,terror factor are significantly lower than the norm before ovulation(P<0.05),Besides,panic and psychosis factors are also sig-nificantly lower than the norm after ovulation(P<0.05).Compared with the first months,prior to ovulation in the sixth months,all factor scores were significantly decreased(P<0.05),but except the terror factor after.The duration of infertility,age,fertility desire,marriage,culture,type of infertility,the monthly income of family and career are risk factors of mental state(P<0.05).Factor Q1 of personality traits is most close to total score of SCL 90(β′=-0.179).Followed by

  4. A maternally inherited autosomal point mutation in human phospholipase C zeta (PLCζ) leads to male infertility.

    Science.gov (United States)

    Kashir, Junaid; Konstantinidis, Michalis; Jones, Celine; Lemmon, Bernadette; Lee, Hoi Chang; Hamer, Rebecca; Heindryckx, Bjorn; Deane, Charlotte M; De Sutter, Petra; Fissore, Rafael A; Parrington, John; Wells, Dagan; Coward, Kevin

    2012-01-01

    Male factor and idiopathic infertility contribute significantly to global infertility, with abnormal testicular gene expression considered to be a major cause. Certain types of male infertility are caused by failure of the sperm to activate the oocyte, a process normally regulated by calcium oscillations, thought to be induced by a sperm-specific phospholipase C, PLCzeta (PLCζ). Previously, we identified a point mutation in an infertile male resulting in the substitution of histidine for proline at position 398 of the protein sequence (PLCζ(H398P)), leading to abnormal PLCζ function and infertility. Here, using a combination of direct-sequencing and mini-sequencing of the PLCζ gene from the patient and his family, we report the identification of a second PLCζ mutation in the same patient resulting in a histidine to leucine substitution at position 233 (PLCζ(H233L)), which is predicted to disrupt local protein interactions in a manner similar to PLCζ(H398P) and was shown to exhibit abnormal calcium oscillatory ability following predictive 3D modelling and cRNA injection in mouse oocytes respectively. We show that PLCζ(H233L) and PLCζ(H398P) exist on distinct parental chromosomes, the former inherited from the patient's mother and the latter from his father. Neither mutation was detected utilizing custom-made single-nucleotide polymorphism assays in 100 fertile males and females, or 8 infertile males with characterized oocyte activation deficiency. Collectively, our findings provide further evidence regarding the importance of PLCζ at oocyte activation and forms of male infertility where this is deficient. Additionally, we show that the inheritance patterns underlying male infertility are more complex than previously thought and may involve maternal mechanisms.

  5. Consequences of infertility in developing countries.

    Science.gov (United States)

    Rouchou, Brittany

    2013-05-01

    Infertility affects more than 10% of the world's population. In developing countries, there are severe social, psychological and economic consequences for infertile men and women. All of the cited references are compiled from primary peer-reviewed research articles that were conducted through one-to-one interviews or focus groups in countries of developing regions, such as Africa, Asia and the Middle East. The following paper seeks to raise awareness of the consequences of infertility in developing nations and identify infertility as an under-observed, but significant public health issue. It is proposed that education programmes tailored to each society's specific religious beliefs and grounded traditions must be implemented in order to reverse the social stigma, detrimental psychological effects, and loss of economic security that results from infertility.

  6. Epigenetic regulatory mechanisms associated with infertility

    DEFF Research Database (Denmark)

    Minocherhomji, Sheroy; Madon, Prochi F; Parikh, Firuza R

    2010-01-01

    Infertility is a complex human condition and is known to be caused by numerous factors including genetic alterations and abnormalities. Increasing evidence from studies has associated perturbed epigenetic mechanisms with spermatogenesis and infertility. However, there has been no consensus...... on whether one or a collective of these altered states is responsible for the onset of infertility. Epigenetic alterations involve changes in factors that regulate gene expression without altering the physical sequence of DNA. Understanding these altered epigenetic states at the genomic level along...... with higher order organisation of chromatin in genes associated with infertility and pericentromeric regions of chromosomes, particularly 9 and Y, could further identify causes of idiopathic infertility. Determining the association between DNA methylation, chromatin state, and noncoding RNAs...

  7. Early Marriage: a Policy for Infertility Prevention

    Directory of Open Access Journals (Sweden)

    Mohammad Ali Karimzadeh

    2008-06-01

    Full Text Available Female fertility begins to decline many years prior to the onset of menopause despite continued regular ovulatory cycles. Age related infertility is due to oocyte abnormalities and decreased ovarian reserve. Treatment of infertility when the cause is limited to decreased ovarian reserve is empirical at present except for oocyte donation. This mini review of the literature covers all available English biomedical journals that have been published from 1995 to 2008. The search based on combination of the words age, fertility, infertility, and oocyte abnormalities. The important findings from this search strategy are summarized and presented in the sub headings including female age and fertility, miscarriage and in vitro fertilization. Regarding infertility prevention, this mini review suggested that early marriage is a primordial, effective, inexpensive and easy way to prevent infertility.

  8. Genetic Association Between Androgen Receptor Gene CAG Repeat Length Polymorphism and Male Infertility: A Meta-Analysis.

    Science.gov (United States)

    Pan, Bihui; Li, Rui; Chen, Yao; Tang, Qiuqin; Wu, Wei; Chen, Liping; Lu, Chuncheng; Pan, Feng; Ding, Hongjuan; Xia, Yankai; Hu, Lingqing; Chen, Daozhen; Sha, Jiahao; Wang, Xinru

    2016-03-01

    The association between polymorphism of androgen receptor gene CAG (AR-CAG) and male infertility in several studies was controversial. Based on studies on association between AR-CAG repeat length and male infertility in recent years, an updated meta-analysis is needed. We aimed to evaluate the association between AR-CAG repeat length and male infertility in advantage of the data in all published reports.We searched for reports published before August 2015 using PubMed, CNKI, VIP, and WanFang. Data on sample size, mean, and standard deviation (SD) of AR-CAG repeat length were extracted independently by 3 investigators.Forty-four reports were selected based on criteria. The overall infertile patients and azoospermic patients were found to have longer AR-CAG repeat length (standard mean difference (SMD) = 0.19, 95% confidence interval (CI): 0.10-0.28, P CAG repeat length was longer in infertile men in Asian, Caucasian, and mixed races (SMD = 0.25, 95% CI: 0.08-0.43, P CAG repeat length was associated with male infertility. The subgroup study on races shows that increased AR-CAG repeat length was associated with male infertility in Asian, Caucasian, and mixed races. Increased AR-CAG repeat length was also associated with azoospermia.This meta-analysis supports that increased androgen receptor CAG length is capable of causing male infertility susceptibility.

  9. Analyses of optimal body mass index for infertile patients with either polycystic or non-polycystic ovary syndrome during assisted reproductive treatment in China

    Science.gov (United States)

    Wang, Fang; Dai, Wei; Yang, Xin-hong; Guo, Yi-hong; Sun, Ying-pu

    2016-01-01

    We observed the effect of body mass index (BMI) on pregnancy outcomes in Chinese patients undergoing assisted reproductive treatment (ART). All the patients were divided into polycystic ovary syndrome (PCOS) group and non-PCOS group, and then according to BMI, each group was subdivided into 6 subgroups: group 1 (BMI  26.0 kg/m2). We found that in 20 to 25-year-old patients, the pregnancy rate was not significantly correlated with BMI in PCOS patients; while in non-POCS patients, the pregnancy rate significantly decreased at the BMI cut-off point value of 24–26 kg/m2. The pregnancy rate significantly declined at the BMI cut-off point values of 22–24 kg/m2 and 18–20 kg/m2, respectively in 25 to 35-year-old and in over 35-year-old PCOS patients; while in over 25-year-old non-PCOS patients, no significant correlation between pregnancy rate and BMI was observed. We conclude that for under 25-year-old non-PCOS patients, ART should be performed after BMI is controlled under 26 kg/m2. For PCOS patients, if age is 25 to 35 years or over 35 years, BMI should be controlled below 24 kg/m2 or below 20 kg/m2, respectively. PMID:27686055

  10. Revised criteria for PCOS in WHO Group II anovulatory infertility – a revival of hypothalamic amenorrhoea?

    DEFF Research Database (Denmark)

    Lauritsen, Mette Petri; Pinborg, Anja; Loft, Anne

    2015-01-01

    OBJECTIVE: To evaluate revised criteria for polycystic ovarian morphology (PCOM) in the diagnosis of polycystic ovary syndrome (PCOS) in anovulatory infertility. DESIGN: Prospective cohort study. PATIENTS: WHO Group II anovulatory infertile women (n = 75). MEASUREMENTS: Clinical, sonographic......% vs 41% (P = 0·003) had an LH/FSH ratio >2 and 19% vs 41% (P = 0·04) had hirsutism and/or elevated total testosterone, free testosterone, and/or androstenedione. The non-PCOM group included significantly more women with secondary infertility. The median AMH in the non-PCOM group was 47 pmol/l, which...... was twofold lower than in the PCOM group but above the upper limit of normo-ovulatory women. CONCLUSIONS: According to a revised threshold of 25 follicles, almost half the anovulatory infertile women do not have PCOM. The characteristics of these women may be compatible with hypothalamic anovulation...

  11. Genetic factors contributing to human primary ciliary dyskinesia and male infertility.

    Science.gov (United States)

    Ji, Zhi-Yong; Sha, Yan-Wei; Ding, Lu; Li, Ping

    2016-06-07

    Primary ciliary dyskinesia (PCD) is an autosomal-recessive disorder resulting from the loss of normal ciliary function. Symptoms include neonatal respiratory distress, chronic sinusitis, bronchiectasis, situs inversus, and infertility. However, only 15 PCD-associated genes have been identified to cause male infertility to date. Owing to the genetic heterogeneity of PCD, comprehensive molecular genetic testing is not considered the standard of care. Here, we provide an update of the progress on the identification of genetic factors related to PCD associated with male infertility, summarizing the underlying molecular mechanisms, and discuss the clinical implications of these findings. Further research in this field will impact the diagnostic strategy for male infertility, enabling clinicians to provide patients with informed genetic counseling, and help to adopt the best course of treatment for developing directly targeted personalized medicine.

  12. Clinical analysis of 129 infertility patients with both fallopian tubes unobstructed and cavitas pelvis fluidify%129例双侧输卵管通畅伴盆腔积液不孕患者的临床分析

    Institute of Scientific and Technical Information of China (English)

    梁雪飞; 王书佳; 柳雪琴

    2010-01-01

    目的 探讨盆腔积液与不孕的关系.方法 回顾性分析阴道超声提示盆腔积液而子宫输卵管造影提示双侧输卵管通畅的129例不孕患者的临床资料.经中药治疗3个月后,盆腔积液消失86例,盆腔积液不消失43例,对两者妊娠率进行比较.结果 盆腔积液消失患者妊娠率为30.23%(26/86),盆腔积液不消失患者妊娠率为6.98%(3/43),两者妊娠率比较差异有统计学意义(P<0.05).未妊娠患者中87例行腹腔镜检查,其中55例为子宫内膜异位症,25例因慢性盆腔炎性疾病引起不同程度的盆腔粘连,1例大量盆腔积液为腹膜结核,6例仅见淡红色盆腔积液而未发现其他异常.31例患者腹腔镜检查术后通过体外受精-胚胎移植获得妊娠.结论 盆腔积液在不孕中有重要临床意义,应积极寻找原因并治疗,以使患者得到有效治疗.%Objective To evaluate the relationship between cavitas pelvis fluidify and infertility.Methods The clinical data of 129 infertility patients which ultrasound hint cavitas pelvis fluidify but hysterosalpingography hint both fallopian tubes to be unobstructed were analyzed retrospectively. The patients were divided into two groups, after 3 months cure with traditional Chinese medicine, the cavitas pelvis fluidify of 86 cases were obsolescent as group Ⅰ , the cavitas pelvis fluidify of 43 cases were no obsolescent as group Ⅱ. Compared their pregnancy rates. Results The pregnancy rate of group Ⅰ was 30.23%(26/86),group Ⅱ was 6.98%(3/43 ), there was significant deviation between the two groups (P < 0.05 ). Eighty-seven patients who were no pregnant were diagnosed laparoscopy, there were 55 cases with endometriosis (EMS), 25 cases with cavitas pelvis accretion, 1 case with tuberculosis of peritoneum, 6 cases with carmoisine cavitas pelvis fluidify without other abnormal. Thirty-one of these patients were pregnant through in vitro fertilization and embryo transfer. Conclusion Cavitas pelvis

  13. First Contact: the intersection of demographics, knowledge, and appraisal of treatment at the initial infertility visit

    Science.gov (United States)

    CHILDRESS, Krista J.; LAWSON, Angela K.; GHANT, Marissa S.; MENDOZA, Gricelda; CARDOZO, Eden R.; CONFINO, Edmond; MARSH, Erica E.

    2015-01-01

    Objective To determine the impact of the initial infertility visit on treatment-related knowledge, patient anxiety, and appraisals of treatment. Study Design Prospective survey. Setting Academic medical center. Patients 234 English-speaking women, ages 18-50, attending their first infertility visit Intervention(s) Participants completed a survey assessing health literacy, knowledge, anxiety, and appraisals of the treatment process before and after their infertility visit. Main Outcome Measure(s) 1) Knowledge of infertility and treatment and, 2) Anxiety and appraisal scores. Results Most participants were white and earned >$100,000/year and had at least a college education. Baseline knowledge of reproductive anatomy, ART, and fertility factors was modest, but improved after the initial visit. Factors associated with higher knowledge included higher education and income, White or Asian ethnicity, and English as their primary language. Patient appraisals of treatment represented by the positive (Challenge) and negative (Threat and Loss) subscale scores on the Appraisal of Life Events (ALE) scale, changed from the pre-visit survey to the post-visit survey. Negative appraisals of treatment and anxiety scores decreased and positive appraisals of treatment increased after the initial visit. Lower knowledge was associated with higher positive appraisal scores lower health literacy was associated with higher anxiety and appraisal scores (positive and negative) post-visit. Black women had higher Challenge scores compared to White and Asian women. Hispanic women had higher anxiety scores than non-Hispanic women. Conclusions Infertility patients have modest baseline knowledge of fertility and infertility treatment. The initial infertility visit can improve this knowledge and decrease both negative appraisals of treatment and anxiety levels. Differences in knowledge and appraisal were seen across ethnic groups and other demographic variables. Physicians should individualize

  14. Infertility

    Science.gov (United States)

    ... problems You've been diagnosed with endometriosis or pelvic inflammatory disease You've had multiple miscarriages You've undergone ... the fallopian tube (salpingitis). This can result from pelvic inflammatory disease, which is usually caused by a sexually transmitted ...

  15. Influence of social supportive care on long term prognosis of infertility patients%社会支持护理对不孕症病人远期预后的影响

    Institute of Scientific and Technical Information of China (English)

    陈雪; 林彤

    2016-01-01

    Objective:To probe into the influence of social support nursing on long term prognosis of infertility patients.Methods:A total of 178 cases of patients with infertility in our hospital from September 2012 to January 2015 were selected;according to 1 ∶ 1 principle and random number table method,patients were divided into support group and control group,89 cases,in each the patients in control group was treated with routine treat-ment and general health education,the patients in support group were given social supportive care on the basis of routine treatment and general health education,nursing observation time of two group was 1 month.Results:After nursing,there were statistically significant difference in scores of anxiety and depression,and scores of ob-jective support,subjective support and social support utilization between both groups(P <0.05);there was sta-tistically significant difference in the rate of intrauterine pregnancy between both groups after six months and 1 years of follow up(P <0.05);During 1 year follow up,scores of somatizootion,obsessive compulsive symp-toms,interpersonal sensitivity,hostility,phobia,paranoid ideation and psychiatric of support group were lower than those control group(P <0.05).Pearson correlation analysis showed that:objective support score was neg-atively correlated with scores of physical,compulsive symptoms and interpersonal relationship(P <0.05),sub-jective support score was negatively correlated with hostility,terror,paranoid score(P <0.05).Conclusion:So-cial supportive care could help to improve infertility patients’social support status,relieve anxiety and depres-sion,and improve mental health of them,and social support existed correlation with mental health of patients.%[目的]探讨社会支持护理对不孕症病人远期预后的影响。[方法]选择2012年9月—2015年1月在我院诊治的不孕症病人178例,按1∶1原则根据随机数字表法分为支持组与对照组各89例,对照组实施

  16. The Potential Use of Intrauterine Insemination as a Basic Option for Infertility: A Review for Technology-Limited Medical Settings

    Directory of Open Access Journals (Sweden)

    Abdelrahman M. Abdelkader

    2009-01-01

    Full Text Available Objective. There is an asymmetric allocation of technology and other resources for infertility services. Intrauterine insemination (IUI is a process of placing washed spermatozoa transcervically into the uterine cavity for treatment of infertility. This is a review of literature for the potential use of IUI as a basic infertility treatment in technology-limited settings. Study design. Review of articles on treatment of infertility using IUI. Results. Aspects regarding the use of IUI are reviewed, including ovarian stimulation, semen parameters associated with good outcomes, methods of sperm preparation, timing of IUI, and number of inseminations. Implications of the finding in light of the needs of low-technology medical settings are summarized. Conclusion. The reviewed evidence suggests that IUI is less expensive, less invasive, and comparably effective for selected patients as a first-line treatment for couples with unexplained or male factor infertility. Those couples may be offered three to six IUI cycles in technology-limited settings.

  17. Definition and epidemiology of unexplained infertility.

    Science.gov (United States)

    Gelbaya, Tarek A; Potdar, Neelam; Jeve, Yadava B; Nardo, Luciano G

    2014-02-01

    The diagnosis of unexplained infertility can be made only after excluding common causes of infertility using standard fertility investigations,which include semen analysis, assessment of ovulation, and tubal patency test. These tests have been selected as they have definitive correlation with pregnancy. It is estimated that a standard fertility evaluation will fail to identify an abnormality in approximately 15% to 30% of infertile couples. The reported incidence of such unexplained infertility varies according to the age and selection criteria in the study population. We conducted a review of the literature via MEDLINE. Articles were limited to English-language, human studies published between 1950 and 2013. Since first coined more than 50 years ago, the term unexplained infertility has been a subject of debate. Although additional investigations are reported to explain or define other causes of infertility, these have high false-positive results and therefore cannot be recommended for routine clinical practice. Couples with unexplained infertility might be reassured that even after 12 months of unsuccessful attempts, 50% will conceive in the following 12 months and another 12% in the year after.

  18. Infertility and pregnancy loss in euthyroid women with thyroid autoimmunity.

    Science.gov (United States)

    Artini, Paolo Giovanni; Uccelli, Alessia; Papini, Francesca; Simi, Giovanna; Di Berardino, Olga Maria; Ruggiero, Maria; Cela, Vito

    2013-01-01

    Thyroid autoimmunity is the most prevalent autoimmune state that affects up to 5-20% of women during the age of fertility. Prevalence of thyroid autoimmunity is significantly higher among infertile women, especially when the cause of infertility is endometriosis or polycystic ovary syndrome. Presence of thyroid autoimmunity does not interfere with normal embryo implantation and have been observed comparable pregnancy rates after assisted reproduction techniques in patients with or without thyroid autoimmunity. Instead, the risk of early miscarriage is substantially raised with the presence of thyroid autoimmunity, even if there was a condition of euthyroidism before pregnancy. Furthermore the controlled ovarian hyperstimulation, used as preparation for assisted reproduction techniques, can severely impair thyroid function increasing circulating estrogen levels. Systematic screening for thyroid disorders in women with a female cause of infertility is controversial but might be important to detect thyroid autoimmunity before to use assisted reproduction techniques and to follow-up these parameters in these patients after controlled ovarian hyperstimulation and during pregnancy.

  19. A study of different treatment of infertile patients with polycystic ovary syndrome%探讨多囊卵巢综合征不孕患者的治疗方式

    Institute of Scientific and Technical Information of China (English)

    崔珺

    2016-01-01

    Objective TO investiGate tHe treatment Of infertiLe patients WitH pOLycystic Ovary syndrOme( PCOS). Methods One Hundred and tHirty-tWO infertiLe patients WitH pOLycystic Ovary syndrOme frOm September 2013 tO September 2014 Were seLected as researcH subjects,tHey Were divided intO ObservatiOn GrOup and cOntrOL GrOup accOrdinG tO tHe differ-ent fOrms Of treatment. THe patients Of cOntrOL GrOup Were treated WitH cLOmipHene,Human menOpausaL GOnaOtrOpin( HMG) and Human cHOriOnic GOnadOtrOpin HOrmOne tO prOmOte OvuLatiOn,tHe patients Of ObservatiOn GrOup Were Given tWO periOds O-raL desOGestreL and eiGHt WeeKs Of metfOrmin firstLy,tHen fOLLOW tHe metHOd Of treatment Of tHe cOntrOL GrOup. THe bOdy WeiGHt,Ovarian vOLume,tHe cHanGes Of LH and testOsterOne LeveLs,OvuLatiOn rate and preGnancy rates WitHin siX mOntHs Were cOmpared after treatment. Results After effective treatment,tHe bOdy WeiGHt,Ovarian vOLume,tHe cHanGes Of LH and testOsterOne LeveLs Of tWO GrOups Had siGnificant differences( P﹤0. 05 );tHe OvuLatiOn rate and preGnancy rates WitHin siX mOntHs Of tHe ObservatiOn GrOup Were siGnificantLy better tHan tHOse Of tHe cOntrOL GrOup( P﹤0. 05 ). Conclusions In terms Of tHe treatment Of infertiLe patients WitH pOLycystic Ovary syndrOme,tHe cLinicaL effect Of desOGestreL cOmbined WitH metfOrmin On prOmOte OvuLatiOn is siGnificantLy better tHan simpLy prOmOte OvuLatiOn.%目的:探讨多囊卵巢综合征不孕患者的治疗方式。方法选取郑州市妇幼保健院2013年9月至2014年9月收治的132例多囊卵巢综合征不孕患者作为研究对象,根据治疗方式的不同分为观察组和对照组,对照组患者采取氯米芬、尿促性素和绒毛膜促性素激素促进排卵治疗,观察组患者先口服2个周期的去氧孕烯及8周的二甲双胍,再给予对照组方法治疗,比较两组患者治疗前后体质量、月经周期、卵巢体积、黄体生成素和睾酮水平的变化情况以及卵巢排卵率和半年内的

  20. Estimating the prevalence of infertility in Canada

    Science.gov (United States)

    Bushnik, Tracey; Cook, Jocelynn L.; Yuzpe, A. Albert; Tough, Suzanne; Collins, John

    2012-01-01

    BACKGROUND Over the past 10 years, there has been a significant increase in the use of assisted reproductive technologies in Canada, however, little is known about the overall prevalence of infertility in the population. The purpose of the present study was to estimate the prevalence of current infertility in Canada according to three definitions of the risk of conception. METHODS Data from the infertility component of the 2009–2010 Canadian Community Health Survey were analyzed for married and common-law couples with a female partner aged 18–44. The three definitions of the risk of conception were derived sequentially starting with birth control use in the previous 12 months, adding reported sexual intercourse in the previous 12 months, then pregnancy intent. Prevalence and odds ratios of current infertility were estimated by selected characteristics. RESULTS Estimates of the prevalence of current infertility ranged from 11.5% (95% CI 10.2, 12.9) to 15.7% (95% CI 14.2, 17.4). Each estimate represented an increase in current infertility prevalence in Canada when compared with previous national estimates. Couples with lower parity (0 or 1 child) had significantly higher odds of experiencing current infertility when the female partner was aged 35–44 years versus 18–34 years. Lower odds of experiencing current infertility were observed for multiparous couples regardless of age group of the female partner, when compared with nulliparous couples. CONCLUSIONS The present study suggests that the prevalence of current infertility has increased since the last time it was measured in Canada, and is associated with the age of the female partner and parity. PMID:22258658

  1. Influence of neurtophil elastase on sperm quality in male infertile patients%男性不育患者精浆中性粒细胞弹性蛋白酶浓度对精子质量的影响

    Institute of Scientific and Technical Information of China (English)

    何碧英; 彭明

    2016-01-01

    目的:探讨男性不育患者精子的质量与精浆中性粒细胞弹性蛋白酶的相关性。方法检测130例不育男性的中性粒细胞弹性蛋白酶浓度,根据精液中性粒细胞弹性蛋白酶浓度将研究对象分为三组,大于1000 ng/m L为A组,250~1000 ng/mL为B组,小于250 ng/mL为C组,对各组精浆中的精液基本参数和生化指标(酸性磷酸酶、枸橼酸、锌和果糖)进行测定。结果(1)A、B、C三组间,精液密度和精子活动率差异有统计学意义(P<0.05),且中性粒细胞弹性蛋白酶浓度与精液密度(r=-0.43)和精子活动率(r=-0.37),精液体积及正常精子形态差异无统计学意义(P>0.05);(2)A、B、C三组间,酸性磷酸酶、柠檬酸和锌浓度差异有统计学意义(P<0.05),且中性粒细胞弹性蛋白酶的浓度与磷酸酶(r=-0.19)、柠檬酸(r=-0.17)和锌(r=-0.23)的浓度呈显著负相关,三组间果糖浓度差异无统计学意义(P>0.05)。结