WorldWideScience

Sample records for nuclear damage

  1. Nuclear damage - civil liability

    International Nuclear Information System (INIS)

    Simoes, A.C.

    1980-01-01

    An analysis is made of the civil liability for nuclear damage since there is a need to adjust the existing rules to the new situations created. The conventions that set up the new disciplining rules not considered in the common law for the liability of nuclear damage are also mentioned. (A.L.) [pt

  2. Risk of nuclear damage

    International Nuclear Information System (INIS)

    Kienzl, K.

    1997-01-01

    Following the opening and words of welcome by Mr. Fritz Unterpertinger (unit director at the Austrian Federal Ministry for the Environment, Youth and Family; BMUJF) Mrs Helga Kromp-Kolb (professor at the Institute for Meteorology and Physics of the University of Natural Resources Science Vienna) illustrated the risks of nuclear damage in Europe by means of a nuclear risk map. She explained that even from a scientific or technical point of view the assessment of risks arising from nuclear power stations was fraught with great uncertainties. Estimates about in how far MCAs (maximum credible accident) could still be controlled by safety systems vary widely and so do assessments of the probability of a core melt. But there is wide agreement in all risk assessments conducted so far that MCAs might occur within a - from a human point of view - conceivable number of years. In this connection one has to bear in mind that the occurrence of such a major accident - whatever its probability may be - could entail immense damage and the question arises whether or not it is at all justifiable to expose the general public to such a risk. Klaus Rennings (Centre for European Economic Research, Mannheim, Germany) dealt with the economic aspects of nuclear risk assessment. He explained that there are already a number of studies available aiming to assess the risk of damage resulting from a core melt accident in economic terms. As to the probability of occurrence estimates vary widely between one incident in 3,333 and 250,000 year of reactor operation. It is assumed, however, that a nuclear accident involving a core melt in Germany would probably exceed the damage caused by the Chernobyl accident. The following speakers addressed the legal aspects of risks associated with nuclear installations. Mrs Monika Gimpel-Hinteregger (professor at the Institute for Civil Law in Graz) gave an overview on the applicable Austrian law concerning third party liability in the field of nuclear energy

  3. Fatigue damage of nuclear facilities

    International Nuclear Information System (INIS)

    2001-01-01

    The conference on the fatigue damage of nuclear facilities, organized by the SFEN (french society of nuclear energy), took place at Paris the 23. of november 2000. Eleven papers were presented, showing the state of the art and the research programs in the domain of the sizing rules, safety, installations damage, examination and maintenance. (A.L.B.)

  4. Terrorism and nuclear damage coverage

    International Nuclear Information System (INIS)

    Horbach, N. L. J. T.; Brown, O. F.; Vanden Borre, T.

    2004-01-01

    This paper deals with nuclear terrorism and the manner in which nuclear operators can insure themselves against it, based on the international nuclear liability conventions. It concludes that terrorism is currently not covered under the treaty exoneration provisions on 'war-like events' based on an analysis of the concept on 'terrorism' and travaux preparatoires. Consequently, operators remain liable for nuclear damage resulting from terrorist acts, for which mandatory insurance is applicable. Since nuclear insurance industry looks at excluding such insurance coverage from their policies in the near future, this article aims to suggest alternative means for insurance, in order to ensure adequate compensation for innocent victims. The September 11, 2001 attacks at the World Trade Center in New York City and the Pentagon in Washington, DC resulted in the largest loss in the history of insurance, inevitably leading to concerns about nuclear damage coverage, should future such assaults target a nuclear power plant or other nuclear installation. Since the attacks, some insurers have signalled their intentions to exclude coverage for terrorism from their nuclear liability and property insurance policies. Other insurers are maintaining coverage for terrorism, but are establishing aggregate limits or sublimits and are increasing premiums. Additional changes by insurers are likely to occur. Highlighted by the September 11th events, and most recently by those in Madrid on 11 March 2004, are questions about how to define acts of terrorism and the extent to which such are covered under the international nuclear liability conventions and various domestic nuclear liability laws. Of particular concern to insurers is the possibility of coordinated simultaneous attacks on multiple nuclear facilities. This paper provides a survey of the issues, and recommendations for future clarifications and coverage options.(author)

  5. Civil liability for nuclear damage

    International Nuclear Information System (INIS)

    1963-01-01

    An international Convention on Civil Liability for Nuclear Damage was adopted in Vienna on 19 May 1963 by a sixty-nation conference convened by the International Atomic Energy Agency. The Convention, which is subject to ratification by the States signing it, will come into force three months after the deposit of the fifth instrument of ratification. The Convention is designee only to establish minimum rules regarding civil liability for nuclear damage; it may thus well be described as a framework convention, the main provisions of which represent the essential common denomination acceptable to as many States as possible. It leaves wide scope for national legislation and regional arrangements with a view to implementing these provisions The Convention does not purport to create a uniform civil law in this field, but it contains the minimal essential for protection of the public and forms the legal basis for uniform world-wide liability rules

  6. Nuclear damage compensation and energy reform

    International Nuclear Information System (INIS)

    Yokemoto, Masafumi

    2013-01-01

    Nuclear damage compensation and energy reform were closely related. Nuclear damage compensation cost should be part of generation cost of nuclear power. Extend of nuclear damage compensation was limited by compensation standard of Tokyo Electric Power Co. (TEPCO) following guidelines of Dispute Reconciliation Committee for Nuclear Damage Compensation. TEPCO had already paid compensation of about two trillion yen until now, which was only a part of total damage compensation cost. TEPCO had been provided more than 3.4 trillion yen by Nuclear Damage Liability Facilitation Cooperation, which would be put back by nuclear operators including TEPCO. TEPCO could obtain present raising funds and try to reconstruct business with restart of nuclear power, which might disturb energy reform. Present nuclear damage compensation scheme had better be reformed with learning more from Minamata disease case in Japan. (T. Tanaka)

  7. Legal protection against nuclear damage

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1959-04-15

    The IAEA Director General appointed an international Panel of Experts to go into the question of Civil Liability and State Responsibility for Nuclear Hazards. The Panel had before it certain basic postulates formulated after a preliminary and tentative consideration of the subject. From the viewpoint of the public, the first postulate is, of course, that the use of nuclear energy be regulated by adequate licensing and control mechanisms so as to prevent any accidents. To the extent, however, that nuclear damage cannot be prevented, there must be liability on the part of the enterprise which caused the damage and, where damage exceeds its liability or its financial resources there should be some assurance of compensation by the State. This should be so not only within the borders of one State, but especially also on an international basis. Security should be required for the possible liability of the enterprises connected with a nuclear incident. Litigation with respect to liability should be concentrated in the most convenient tribunal and be governed by a single clearly defined law. The methods of distribution should meet general standards of equity and be as expeditious as possible. Emergency measures, especially evacuation, first aid and decontamination, should be organized and financed without delay. At the same time, the liability of an enterprise should not exceed its reasonable financial capabilities. This means that a ceiling should be imposed upon the amount of third party liability to which an enterprise could be held. And the liability should generally be such as can be covered by adequate financial security. Uniformity in the treatment of victims of nuclear incidents in all these fields is a desirable goal. Yet, if a rule adopted on an international level or suggested by uniform legislation were to be viable, it should adapt itself to the social, economic and legal order already existing in individual States. This may mean that in certain fields it

  8. Legal protection against nuclear damage

    International Nuclear Information System (INIS)

    1959-01-01

    The IAEA Director General appointed an international Panel of Experts to go into the question of Civil Liability and State Responsibility for Nuclear Hazards. The Panel had before it certain basic postulates formulated after a preliminary and tentative consideration of the subject. From the viewpoint of the public, the first postulate is, of course, that the use of nuclear energy be regulated by adequate licensing and control mechanisms so as to prevent any accidents. To the extent, however, that nuclear damage cannot be prevented, there must be liability on the part of the enterprise which caused the damage and, where damage exceeds its liability or its financial resources there should be some assurance of compensation by the State. This should be so not only within the borders of one State, but especially also on an international basis. Security should be required for the possible liability of the enterprises connected with a nuclear incident. Litigation with respect to liability should be concentrated in the most convenient tribunal and be governed by a single clearly defined law. The methods of distribution should meet general standards of equity and be as expeditious as possible. Emergency measures, especially evacuation, first aid and decontamination, should be organized and financed without delay. At the same time, the liability of an enterprise should not exceed its reasonable financial capabilities. This means that a ceiling should be imposed upon the amount of third party liability to which an enterprise could be held. And the liability should generally be such as can be covered by adequate financial security. Uniformity in the treatment of victims of nuclear incidents in all these fields is a desirable goal. Yet, if a rule adopted on an international level or suggested by uniform legislation were to be viable, it should adapt itself to the social, economic and legal order already existing in individual States. This may mean that in certain fields it

  9. The law concerning liability for nuclear damage

    International Nuclear Information System (INIS)

    Kinouchi, Kazuo

    1978-01-01

    This treatise outlines the Law on Compensation for Nuclear Damage (Law No. 147, June 17, 1961) and the Law on Indemnity Agreement for Compensation of Nuclear Damage (Law, No. 148, June 17, 1961) which are both came into effect in March, 1962, and describes how these laws will be executed if an accident occurs actually in nuclear facilities. The first law which prescribes various provisions for compensation of nuclear damage is characterised as having the principle of no-fault liability and hence making a nuclear enterpriser responsible for securing adequate financial resources to indemnify general public for their damages from nuclear accidents. Thus, in compliance with the law a nuclear enterpriser should effect both the contract of the indemnity responsible insurance and the indemnity agreement for compensation of nuclear damage. The second law deals with the indemnity agreement which is concluded by a nuclear enterpriser with the government and constitutes a full measure for compensation of nuclear damage supplementing the indemnity responsible insurance. The indemnity agreement is to insure compensation liabilities for nuclear damages which the indemnity responsible insurance can not cover-that is, damages caused by earthquakes and volcanic eruptions, and also damages from normal operations of nuclear facilities and those occurs after 10 years of an accident. Then, the author describes in detail how these laws apply in a nuclear accident to damages to third parties and those to facilities of related nuclear enterpriser himself and to his employees. Finally, the author refers to the legal systems for compensation of nuclear damage in the United States, Britain, France and West Germany. (Matsushima, A.)

  10. Civil liability for nuclear and radiological damage

    International Nuclear Information System (INIS)

    Puig, D.

    2001-10-01

    The present work gives details of the nuclear damage, the accidents of Chernobil, three Mile Inland and Tokaimura with their respective legal consequences, the nature of the responsibility and bases for their establishment, conventions about civil responsibility for nuclear damages to regional and world level as well as other condition of conventions of the Ibero-American countries with regard to the approval of the conventions it has more than enough civil responsibility for nuclear and radiological accident damages

  11. Civil liability for nuclear damage law

    International Nuclear Information System (INIS)

    1974-01-01

    This Law has as its main objective to regulate civic responsability on damages or injuries that may be brought about by the usage of nuclear reactors and the use of nuclear substances or fuels and their consecuent wastes. The text of this law is consituted by 5 chapters that deal with the following subjects: CHAPTER ONE.- Objective and Definitions. CHAPTER TWO.-On Civic Responsability on Nuclear Damages or Injuries. CHAPTER THREE.- On the Limits of Responsability. CHAPTER FOUR.- On Prescription. CHAPTER FIVE.- General Regulations Concepts such as the following are defined concretely and precisely: Nuclear Accident, Nuclear Damage or Injury, Atomic Energy, Operator of a Nuclear Facility, Nuclear Facility, Radioactive Product or Waste Material, Nuclear Reactor, Nuclear Substances Remittance and Hazardous Nuclear Substance

  12. The law concerning indemnification of nuclear damage

    International Nuclear Information System (INIS)

    1977-01-01

    This Law aims at determining the basic system concerning indemnification for nuclear damage caused by the operation of reactors, fabrication, reprocessing and use of nuclear fuel materials as well as the transportation, storing or disposal of such materials or those contaminated by such materials (including fission products) accompanying these operations in view of protecting the sufferers and contributing to the wholesome development of atomic energy enterprises. The ''nuclear damage'' referred to in this Law is the damages caused by the action during the process of fission of nuclear fuel materials or the action of radiation or the poisonous action of said nuclear fuel materials or matters contaminated by said materials (those causing poisoning or deuteropathy in human bodies by taking in or inhaling such materials). Upon giving nuclear damage by the operation of reactors and others, the atomic energy entrepreneurs concerned are responsible for indemnifying the damage. Atomic energy entrepreneurs should not operate reactors without first taking the measures for indemnifying nuclear damages. Said measures are conclusion of nuclear damage indemnification responsibility insurance contract and nuclear damage indemnification contract or deposit, by which 6,000 million yen may be earmarked for such indemnification per factory, place of business or nuclear ship

  13. Convention on supplementary compensation for nuclear damage

    International Nuclear Information System (INIS)

    Chinese Nuclear Society, Beijing; U.S. Nuclear Energy Institute

    2000-01-01

    The Contracting parties recognize the importance of the measures provided in the Vienna Convention on Civil Liability for Nuclear Damage and the Paris Convention on Third party liability in the Field of Nuclear Energy as well as in national legislation on compensation for nuclear damage consistent with the principles of these conventions. The Contracting parties desire to establish a worldwide liability regime to supplement and enhance these measures with a view to increasing the amount of compensation for nuclear damage and encourage regional and global co-operation to promote a higher level of nuclear safety in accordance with the principle of international partnership and solidarity

  14. The law concerning indemnification of nuclear damage

    International Nuclear Information System (INIS)

    1979-01-01

    The law defines the basic system of indemnification of nuclear damage by the operation of reactors to protect sufferers and help the sound development of atomic energy business. The operation of reactors means hereunder the operation of reactors, processing, reprocessing and the uses of nuclear fuel materials as well as transport, storage and disposal of nuclear fuel materials or things contaminated by them, which accompany with those procedures. The nuclear damage signifies injuries due to functions of fission of nuclear fuel materials or radiation or poisonous functions of things contaminated by them. When nuclear damage happens by the operation of reactors, the atomic energy enterpriser concerned shall indemnify the damage. Atomic energy undertakers shall not operate reactors without taking measures for compensation. The measures shall be the conclusion of nuclear damage compensation insurance contracts and indemnification contracts or the deposit. The amount of less than yen 10 milliards specified by the order and acknowledged by the Director General of Science and Technology Agency shall be allotted to the compensation by these measures for each works, enterprise or nuclear ship. The government shall assist atomic energy enterprisers to indemnify, when such compensation surpasses the amount assigned and the support is considered necessary. (Okada, K.)

  15. Convention on supplementary compensation for nuclear damage

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-07-22

    The document reproduces the text of the Convention on Supplementary Compensation for Nuclear Damage which was adopted on 12 September 1997 by a Diplomatic Conference held between 8-12 September 1997 in Vienna

  16. Convention on supplementary compensation for nuclear damage

    International Nuclear Information System (INIS)

    1998-01-01

    The document reproduces the text of the Convention on Supplementary Compensation for Nuclear Damage which was adopted on 12 September 1997 by a Diplomatic Conference held between 8-12 September 1997 in Vienna

  17. Liability for nuclear damage and compensation therefor

    International Nuclear Information System (INIS)

    Prochazkova, D.

    1996-01-01

    The basic principles are outlined of the Paris Convention on Third Party Liability in the Field of Nuclear Energy, the Brussels Convention Supplementary to the Paris Convention, the Vienna Convention on Civil Liability for Nuclear Damage, and the Joint Protocol Relating to the Application of the Paris Convention and the Vienna Convention. (P.A.)

  18. Third party liability for nuclear damage

    International Nuclear Information System (INIS)

    Crancher, D.W.

    1976-12-01

    Basic principles of nuclear liability legislation are discussed including absolute and limited liability and the role of the Sovereign State in idemnifying the operator for damage in excess of limited liability. European counrties realised the need for unifying the law of nuclear instability and efforts were made accordingly towards producing workable international conventions. The world's first legislation on nuclear liability - the USA Price-Anderson Act - is described in detail and a digest of nuclear liability claims experience is given. Observations of the present status of nuclear third party liability are outlined. (Author)

  19. Genetic damage following nuclear war

    International Nuclear Information System (INIS)

    Oftedal, P.

    1984-01-01

    Genetic damage may be caused by ionizing radiation from the exploding bomb itself, or from radioactive nuclides released or formed in the explosion. Long-wave radiation in the heat flash and physical force do not contribute. Thus only a small fraction of the energy of the explosion - fission or fusion- can cause genetic damage. Neutron irradiation is generally found to be 5-20 times more efficient than gamma irradiation for the same absorbed dose. Fetuses and children are generally more radiosensitive than adults. Exposure of gonads during the proliferative stage of gonad growth may conceivably lead to a ''fluctuation test'' effect, so that a gonad may contain a sector of cells carrying identical mutations. A corresponding development may take place if the gonad stem cell population has been severely depleted by an acute exposure and recovers

  20. Radiation damage studies of nuclear structural materials

    International Nuclear Information System (INIS)

    Barat, P.

    2012-01-01

    Maximum utilization of fuel in nuclear reactors is one of the important aspects for operating them economically. The main hindrance to achieve this higher burnups of nuclear fuel for the nuclear reactors is the possibility of the failure of the metallic core components during their operation. Thus, the study of the cause of the possibility of failure of these metallic structural materials of nuclear reactors during full power operation due to radiation damage, suffered inside the reactor core, is an important field of studies bearing the basic to industrial scientific views.The variation of the microstructure of the metallic core components of the nuclear reactors due to radiation damage causes enormous variation in the structure and mechanical properties. A firm understanding of this variation of the mechanical properties with the variation of microstructure will serve as a guide for creating new, more radiation-tolerant materials. In our centre we have irradiated structural materials of Indian nuclear reactors by charged particles from accelerator to generate radiation damage and studied the some aspects of the variation of microstructure by X-ray diffraction studies. Results achieved in this regards, will be presented. (author)

  1. Liability for nuclear damage. An international perspective

    International Nuclear Information System (INIS)

    Lopuski, J.

    1993-01-01

    The book deals with some of the complex issues of liability and compensation for nuclear damage which have been considered in the course of the work of the IAEA concerning the revision of the Vienna Convention on nuclear liability. It presents, in an orderly way, personal reflections of its author based on this experience gathered in years 1989-1992 when participating in this work. Necessarily it contains in some of its parts references to documents of the IAEA Standing Committee on Nuclear Liability; these documents because of their length could not be reproduced. Consequently these parts may be fully intelligible for those who have not participated in or closely followed in Committee's work. The IAEA work on liability for nuclear damage was initiated in the wake of the impact made on the world's public opinion by the Chernobyl incident and its transboundary effects; issues of international state liability and full compensation have been raised. But humanitarian ideas have quickly been confronted with cold calculations of the cost of financial protection for victims and an open unwillingness of some nuclear states the engage their liability; conflict of interests between nuclear and non-nuclear states has been manifested. After three years of discussion no wide consensus could be reached on some basic issues, such as: relationship between international state and civil liability regimes, structures of international legislation, concept of nuclear damage, limits of compensation, role of public funds or jurisdiction. The author presents his approach to these controversial issues, trying to provide at the same time a theoretical outline for the future international legislation on nuclear liability. (author)

  2. Liability and damages in Japanese nuclear law

    International Nuclear Information System (INIS)

    Hoshino, E.

    1981-01-01

    The Japanese legislation relating to nuclear liability is based on two laws which date back to 1961, i.e. the law concerning compensation for nuclear damage and the law concerning financial damage compensation indemnification. In Japan, the legal channelling of liability is in force, a contractual recourse is not possible unless there is intent. The financial security act in Japan consists of a (third-party) liability insurance contract concluded with a private insurer and the cover contract concluded with the state. According to the agreement on financial security concluded between government and operator, the operator has to pay the state a certain sum per year. Basically, the amount covered is DM 50 million per site. This sum will be increased to DM 90 million. The operator is fully liable. The state is not bound by law to fully cover damages but will be - de facto - prepared to do so anyway. For potential damage to personnel, the social insurance law is applicable as it is in the Federal Republic of Germany. However, this damage is intended to be subject to nuclear liability, to be effected by an amendmend. (orig./HP) [de

  3. Liability for on-site nuclear property damage

    International Nuclear Information System (INIS)

    Neems, H.J.

    2000-01-01

    Typically, liability for on-site property addressed in contracts between operator and its suppliers. Nuclear power plant operators ordinarily protect themselves against risk of nuclear damage to on-site property by insurance. Nuclear liability laws do not specifically address liability for nuclear damage to on-site property. Nuclear plant owners should address risk of damage to on-site property when developing risk management program

  4. Radiation damage in nuclear waste materials

    International Nuclear Information System (INIS)

    Jencic, I.

    2000-01-01

    Final disposal of high-level radioactive nuclear waste is usually envisioned in some sort of ceramic material. The physical and chemical properties of host materials for nuclear waste can be altered by internal radiation and consequently their structural integrity can be jeopardized. Assessment of long-term performance of these ceramic materials is therefore vital for a safe and successful disposal. This paper presents an overview of studies on several possible candidate materials for immobilization of fission products and actinides, such as spinel (MgAl 2 O 4 ), perovskite (CaTiO 3 ), zircon (ZrSiO 4 ), and pyrochlore (Gd 2 Ti 2 O 7 and Gd 2 Zr 2 O 7 ). The basic microscopic picture of radiation damage in ceramics consists of atomic displacements and ionization. In many cases these processes result in amorphization (metaminctization) of irradiated material. The evolution of microscopic structure during irradiation leads to various macroscopic radiation effects. The connection between microscopic and macroscopic picture is in most cases at least qualitatively known and studies of radiation induced microscopic changes are therefore an essential step in the design of a reliable nuclear waste host material. The relevance of these technologically important results on our general understanding of radiation damage processes and on current research efforts in Slovenia is also addressed. (author)

  5. International Co-operation in providing insurance cover for nuclear damage to third parties and for damage to nuclear installations

    International Nuclear Information System (INIS)

    Deprimoz, Jacques

    1983-01-01

    This article in three parts analyses cover for damage to third parties by fixed nuclear installations, cover for damage to third parties during transport of nuclear substances and finally, cover for damage to nuclear installations. Part I reviews the principles of nuclear third party liability and describes nuclear insurance pools, the coverage and contracts provided. Part II describes inter alia the role of pools in transport operations as well as the type of contracts available, while Part III discusses material damage, the pools' capacities and the vast sums involved in indemnifying such damage. (NEA) [fr

  6. Compensation for damages in case of a nuclear accident

    International Nuclear Information System (INIS)

    Leger, M.

    2011-01-01

    This article presents the system of compensation for damages in case of a nuclear accident. This system of civil liability for nuclear damage, as a specific regime, departs on several points from the common rules of civil liability, in order to provide an adequate and equitable compensation for the damages suffered by the victims of nuclear accidents. The French system of civil liability for nuclear damage results from two International Conventions integrated in French law (Paris convention 1960 and Brussels convention 1963) and the French law of 1968, October 30 on civil liability in the area of nuclear energy. These texts define the conditions under which a nuclear operator could be held liable in case of a nuclear accident. The protocols to amend the Paris and Brussels Conventions of 2004, not yet come into force, are also presented. They ensure that increased resources are available to compensate a greater number of victims of a nuclear accident. (author)

  7. Report of the working group for nuclear damage compensation system

    International Nuclear Information System (INIS)

    1989-01-01

    The Working Group for Nuclear Damage Compensation System was established within the Atomic Energy Commision of Japan on August 2, 1988. The Group has held five meetings to make a study on the revision of the reserve for nuclear damage compensation. The nuclear damage compensation system in Japan has been established under the Law Concerning Compensation for Nuclear Damages and the Law Concerning Contract for Compensation for Nuclear Damages. The former law requires the nuclear power plant operators to set up a reserve for damage compensation to ensure positive and quick payment of compensation in the event of an accident. The reserve is currently rely on liability insurance and a government compensation contract. The Working Group has concluded that the total reserve should be increased from the current yen10 bill. to yen30 bill. The amount of the reserve specified in the enforcement law for the Law Concerning Compensation for Nuclear Damages should also be increased accordingly. The Law Concerning compensation for Nuclear damage will also be applied to damage which occurs overseas as a result of an accident in Japan. (N.K.)

  8. The 1968 Brussels convention and liability for nuclear damage

    International Nuclear Information System (INIS)

    Sands, Ph.; Galizzi, P.

    2000-01-01

    The legal regime governing civil liability for transboundary nuclear damage is expressly addressed by two instruments adopted in the 1960's: the 1960 Paris Convention on Third Party Liability in the Field of Nuclear Energy and the 1963 Vienna Convention on Civil Liability for Nuclear Damage These establish particular rules governing the jurisdiction of national courts and other matters, including channelling of liability to nuclear operators, definitions of nuclear damage, the applicable standard of care, and limitations on liability. Another instrument - the 1968 Brussels Convention on Jurisdiction and the Enforcement of Judgements in Civil and Commercial Matters (hereinafter referred to as 'the Brussels Convention') - which is not often mentioned in the nuclear context will nevertheless also be applicable in certain cases. It is premised upon different rules as to forum and applicable law, and presents an alternate vision of the appropriate arrangements governing civil liability for nuclear damage. In this paper we consider the relative merits and demerits of the Brussels Convention from the perspective of non-nuclear states which might suffer damage as a result of a nuclear accident in another state. We conclude that in the context of the applicability of the Brussels Convention the dedicated nuclear liability conventions present few attractions to non-nuclear states in Europe. We focus in particular on issues relating to jurisdiction and applicable law, and do so by reference to a hypothetical accident in the United Kingdom which has transboundary effects in Ireland. (author)

  9. DNA damage-induced inflammation and nuclear architecture.

    Science.gov (United States)

    Stratigi, Kalliopi; Chatzidoukaki, Ourania; Garinis, George A

    2017-07-01

    Nuclear architecture and the chromatin state affect most-if not all- DNA-dependent transactions, including the ability of cells to sense DNA lesions and restore damaged DNA back to its native form. Recent evidence points to functional links between DNA damage sensors, DNA repair mechanisms and the innate immune responses. The latter raises the question of how such seemingly disparate processes operate within the intrinsically complex nuclear landscape and the chromatin environment. Here, we discuss how DNA damage-induced immune responses operate within chromatin and the distinct sub-nuclear compartments highlighting their relevance to chronic inflammation. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  10. Compensation for nuclear damage in the OECD member countries

    International Nuclear Information System (INIS)

    1977-01-01

    The study aims to describe briefly the main features of the system for compensation of nuclear damage in OECD Member Countries, emphasising the practical arrangements for compensating such damage, with illustrations drawn from various national legal provisions applicable to such cases. The study indicates and compares legislative provisions which are specifically nuclear, without going into the substantive and procedural rules of the general law, reference to which frequently occurs in enactments relating to nuclear third party liability. The references to national nuclear legislation illustrate the manner in which effect has been given to international Conventions. (Auth.) [fr

  11. Nuclear Liability and Insurance for Nuclear Damage in Sweden

    International Nuclear Information System (INIS)

    Thofelt, H.

    1998-01-01

    This paper contains some facts about the Swedish nuclear energy production system and about the nuclear operators liability with the important issues. The nuclear insurance of Sweden is also explained in short terms. (author)

  12. Nuclear Liability and Insurance for nuclear Damage in Switzerland

    International Nuclear Information System (INIS)

    Reitsma, S. M. S.

    1998-01-01

    With nuclear power generating 43% of its total electricity production, Switzerland is amongst the states, employing the highest percentage of nuclear electricity. Although, the country has not ratified any of the international Nuclear Liability Conventions, its Nuclear Third Party Liability Act reflects all the principles, underlying those Conventions. The statutory liability of the operator of a Swiss nuclear installation itself being unlimited, the total insurance limit of CHF 770 m. provides the highest private insurance protection worldwide. With the support of its foreign Reinsurance Pools, the capacity for this insurance guarantee has, over more than 40 years, been built up by the Swiss Nuclear Insurance Pool. Apart from Third Party Liability cover, the Pool also provides Property insurance to Swiss nuclear installation operators and reinsurance cover to other nuclear insurers worldwide. (author)

  13. The law on indemnity agreement for compensation of nuclear damage

    International Nuclear Information System (INIS)

    1979-01-01

    Basic terms are defined, such as: operation of reactors; nuclear damage; nuclear enterpriser; nuclear ship; measure for compensation; amount of compensation and liability insurance contract. The government may conclude with nuclear enterprisers indemnity agreements, in which in the case of reparation responsibilities of the enterprisers coming into being, the government agrees to make for losses of the enterprisers not possible to be compensated by liability insurance contracts, etc., and the enterprisers comply to pay indemnity charges. Losses indemnified by the government with the said agreements (indemnity agreement) shall be losses of the enterprisers (indemnity loss) which occur from reparation of nuclear damages due to earthquakes or eruptions, or regular operation of reactors or damages to be compensated by the insurance contracts, which are not demanded by the sufferers for 10 years from the day of events, and others. The term of indemnity agreements is from the time of the conclusion to the date of suspension of the operation of reactors. Indemnity charges, amount of indemnity, limit of conclusion of indemnity agreements, notice, prescription and others are prescribed respectively. The government may dissolute indemnity agreements in specified particular cases, including violation of the provisions of the law concerning indemnification of nuclear damage by the enterprisers, etc. (Okada, K.)

  14. Compensation of damage caused by diverted nuclear substances

    International Nuclear Information System (INIS)

    Deprimoz, J.

    1981-10-01

    This paper provides a comprehensive analysis of the insurance system for nuclear liability. As a rule, if nuclear fuel, radioactive products or waste are governed by nuclear energy law providing for strict and channelled liability, their legal holder will pay for damage arising from them anywhere within 20 years after theft or diversion and 10 years after the nuclear incident. In most countries, atomic liability insurers will implicitly grant their cover through policies underwritten by legal holders. If diverted substances have a low specific radioactivity, their legal holder remains liable according to common law and insurance policies cover this conventional liability. (NEA) [fr

  15. Act of 19 June 1974 on Compensation for Nuclear Damage

    International Nuclear Information System (INIS)

    1974-01-01

    This Act which came into force on 18 September 1974 replaces the nuclear third party liability provisions of the 1962 Act on nuclear installations. Its adoption enabled the Danish Government to ratify the 1960 Paris Convention and the 1963 Brussels Supplementary Convention. In accordance with the principles prescribed by these Conventions, the Act establishes an absolute and limited third party liability system (75 million Danish Krone) and compulsory insurance for the operator of a nuclear installation situated in Denmark. In certain conditions, the State may have to intervene to ensure compensation of nuclear damage exceeding the financial security provided by the operator liable. (NEA) [fr

  16. Third party liability cover for nuclear damage and related problems

    International Nuclear Information System (INIS)

    Carbone, Ferdinando; Gambardella, Elio.

    1974-06-01

    This paper analyses the financial security and cover for third party liability for nuclear damage as provided for by Act No. 1860 of 31 December 1962 on the peaceful uses of nuclear energy. The relevant Sections of the Act are quoted and explained, as are the nuclear operator's obligation to furnish financial security for his liability. Different possible types of security and cover are described, also with reference to other national legislation. Finally, the author mentions the Paris Convention which provides the basis for Italian nuclear third party liability legislation. (NEA) [fr

  17. Economic damage caused by a nuclear reactor accident

    International Nuclear Information System (INIS)

    Goemans, T.; Schwarz, J.J.

    1988-01-01

    This study is directed towards the estimation of the economic damage which arises from a severe possible accident with a newly built 1000 MWE nuclear power plant in the Netherlands. A number of cases have been considered which are specified by the weather conditions during and the severity of the accident and the location of the nuclear power plant. For each accident case the economic damage has been estimated for the following impact categories: loss of the power plant, public health, evacuation and relocation of population, export of agricultural products, working and living in contaminated regions, decontamination, costs of transportation and incoming foreign tourism. The consequences for drinking water could not be quantified adequately. The total economic damage could reach 30 billion guilders. Besides the power plant itself, loss of export and decreasing incoming foreign tourism determine an important part of the total damage. 12 figs.; 52 tabs

  18. Survey of Codes Employing Nuclear Damage Assessment

    Science.gov (United States)

    1977-10-01

    surveyed codes were com- DO 73Mu 1473 ETN OF 1NOVSSSOLETE UNCLASSIFIED 1 SECURITY CLASSIFICATION OF THIS f AGE (Wh*11 Date Efntered)S<>-~C. I UNCLASSIFIED...level and above) TALLEY/TOTEM not nuclear TARTARUS too highly aggregated (battalion level and above) UNICORN highly aggregated force allocation code...vulnerability data can bq input by the user as he receives them, and there is the abil ’ity to replay any situation using hindsight. The age of target

  19. Radiation damage in nuclear waste ceramics

    International Nuclear Information System (INIS)

    Turcotte, R.P.; Roberts, F.P.; Rusin, J.M.; Wald, J.W.

    1982-01-01

    The text contains a number of specific observations about the radiation-induced changes in glass, glass-ceramic, and supercalcine nuclear waste forms. Other, more general conclusions can be summarized: Radiation-induced property changes follow an exponential ingrowth curve to saturation. Actinide host phases in both crystalline waste forms become X-ray amorphous. The magnitudes of the waste-form density changes observed could not be directly related to observed changes in the primary actinide phases. Although large crystal-structure changes occur in the materials studied, obvious physical degradation was not observed

  20. Damage caused to houses and equipment by underground nuclear explosions

    International Nuclear Information System (INIS)

    Delort, F.; Guerrini, C.

    1969-01-01

    A description is given of the damaged caused to various structures, buildings, houses, mechanical equipment and electrical equipment by underground nuclear explosions in granite. For each type of equipment or building are given the limiting distances for a given degree of damage. These distances have been related to a parameter characterizing the movement of the medium; it is thus possible to generalize the results obtained in granite, for different media. The problem of estimating the damage caused at a greater distance from the explosion is considered. (authors) [fr

  1. Indemnification of damage in the event of a nuclear accident

    International Nuclear Information System (INIS)

    2003-01-01

    The Workshop on the Indemnification of Damage in the Event of a Nuclear Accident, organised by the OECD Nuclear Energy Agency in close co-operation with the French authorities, was held in Paris from 26 to 28 November 2001. This event was an integral part of the International Nuclear Emergency Exercise INEX 2000. It attracted wide participation from national nuclear authorities, regulators, operators of nuclear installations, nuclear insurers and international organisations. The objective was to test the capacity of the existing nuclear liability and compensation mechanisms in the 29 countries represented at the workshop to manage the consequences of a nuclear emergency. This workshop was based upon the scenario used for the INEX 2000 Exercise, i.e. an accident simulated at the Gravelines nuclear power plant in the north of France in May 2001. These proceedings contain a comparative analysis of legislative and regulatory provisions governing emergency response and nuclear third party liability, based upon country replies to a questionnaire. This publication also includes the full responses provided to that questionnaire, as well as the texts of presentations made by special guests from Germany and Japan describing the manner in which the public authorities in their respective countries responded to two nuclear accidents of a very different nature and scale. (authors)

  2. Fundamental Technology Development for Radiation Damage in Nuclear Materials

    International Nuclear Information System (INIS)

    Kwon, Sang Chul; Kwon, J. H.; Kim, E. S. and others

    2005-04-01

    This project was performed to achieve technologies for the evaluation of radiation effects at materials irradiated at HANARO and nuclear power plants, to establish measurement equipment and software for the analysis of radiation defects and to set up facilities for the measurements of radiation damage with non-destructive methods. Major targets were 1) establishment of hot laboratories and remote handling facilities/ technologies for the radioactive material tests, 2) irradiation test for the simulation of nuclear power plant environment and measurement/calculation of physical radiation damage, 3) evaluation and analysis of nano-scale radiation damage, 4) evaluation of radiation embrittlement with ultrasonic resonance spectrum measurement and electromagnetic measurement and 5) basic research of radiation embrittlement and radiation damage mechanism. Through the performance of 3 years, preliminary basics were established for the application research to evaluation of irradiated materials of present nuclear power plants and GEN-IV systems. Particularly the results of SANS, PAS and TEM analyses were the first output in Korea. And computer simulations of radiation damage were tried for the first time in Korea. The technologies will be developed for the design of GEN-IV material

  3. Nuclear data for radiation damage assessment and related safety aspects

    International Nuclear Information System (INIS)

    Kocherov, N.P.

    1989-12-01

    The IAEA Advisory Group Meeting on Nuclear Data for Radiation Damage Assessment and Related Safety Aspects was held at the IAEA Headquarters in Vienna, 19-22 September 1989. This report contains the conclusions and recommendations of this meeting. The papers which the participants prepared for and presented at the meeting will be published as an IAEA Technical Document. (author)

  4. Vienna convention on civil liability for nuclear damage

    International Nuclear Information System (INIS)

    1996-01-01

    The Vienna Convention on Civil Liability for Nuclear Damage was adopted on 21 May 1963 and was opened for signature on the same day. It entered into force on 12 November 1977, i.e. three months after the date of deposit with the Director General of the fifth instrument of ratification, in accordance with Article 23

  5. Vienna convention on civil liability for nuclear damage

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-20

    The Vienna Convention on Civil Liability for Nuclear Damage was adopted on 21 May 1963 and was opened for signature on the same day. It entered into force on 12 November 1977, i.e. three months after the date of deposit with the Director General of the fifth instrument of ratification, in accordance with Article 23.

  6. The law on indemnity agreement for compensation of nuclear damage

    International Nuclear Information System (INIS)

    1977-01-01

    The Government can conclude the contract with atomic energy entrepreneurs promising that it would indemnify the loss caused by the payment of indemnity by the latter for the nuclear damage which cannot be covered with responsibility insurance contract and other measures for indemnifying the damages upon the occurrence of responsibility of said entrepreneurs, who promises to pay the rate for indeminty. The loss to be indemnified by the Government with said contract should be limited to the loss caused by the payment of indemnity by said entrepreneurs for the damage caused by earthquakes or volcanic activities, normal operation of reactors (to be specified by the cabinet order) or the damage which can be covered with the responsibility insurance contract so long as the fact becoming its cause is concerned and the indemnification for which was not demanded by the sufferer in 10 years elapsed since the outbreak of such fact, and the damage caused by the entry of nuclear ships in foreign territorial waters, which cannot be covered with the measures for indemnifying the damage. The sum of the rate for indemnity is specified

  7. Indemnification of Damage in the Event of a Nuclear Accident

    International Nuclear Information System (INIS)

    2006-01-01

    The Second International Workshop on the Indemnification of Nuclear Damage was held in Bratislava, Slovak Republic, from 18 to 20 May 2005. The workshop was co-organised by the OECD Nuclear Energy Agency and the Nuclear Regulatory Authority of the Slovak Republic. It attracted wide participation from national nuclear authorities, regulators, operators of nuclear installations, nuclear insurers and international organisations. The purpose of the workshop was to assess the third party liability and compensation mechanisms that would be implemented by participating countries in the event of a nuclear accident taking place within or near their borders. To accommodate this objective, two fictitious accident scenarios were developed: one involving a fire in a nuclear installation located in the Slovak Republic and resulting in the release of significant amounts of radioactive materials off-site, and the other a fire on board a ship transporting enriched uranium hexafluoride along the Danube River. The first scenario was designed to involve the greatest possible number of countries, with the second being restricted to countries with a geographical proximity to the Danube. These proceedings contain the papers presented at the workshop, as well as reports on the discussion sessions held. (author)

  8. Costs for insurance of civil responsibility for nuclear damage during transportation of nuclear materials

    International Nuclear Information System (INIS)

    Amelina, M.E.; Arsent'ev, S.V.; Molchanov, A.S.

    2009-01-01

    The article considers the method of calculation of rates for insurance of civil responsibility for nuclear damage during transportation of nuclear materials, which can minimize the insurer's costs for this type of insurance in situation when there is no statistics available and it is not possible to calculate the insurance rate by the traditional means using the probability theory

  9. Study on radiation damage of electron and γ-rays and mechanism of nuclear hardening

    International Nuclear Information System (INIS)

    Jing Tao

    2001-01-01

    Radiation damage effects of electrons and γ-rays are presented. The damage defects are studied by experimental methods. On the basis of these studies the damage mechanism and nuclear hardening techniques are studied

  10. Advanced nuclear data for radiation-damage calculations

    International Nuclear Information System (INIS)

    MacFarlane, R.E.; Foster, D.G. Jr.

    1983-01-01

    Accurate calculations of atomic displacement damage in materials exposed to neutrons require detailed spectra for primary recoil nuclei. Such data are not available from direct experimental measurements. Moreover, they cannot always be computed accurately starting from evaluated nuclear data libraries such as ENDF/B-V that were developed primarily for neutron transport applications, because these libraries lack detailed energy-and-angle distributions for outgoing charged particles. Fortunately, a new generation of nuclear model codes is now available that can be used to fill in the missing spectra. One example is the preequilibrium statistical-model code GNASH. For heating and damage applications, a supplementary code called RECOIL has been developed. RECOIL uses detailed reaction data from GNASH, together with angular distributions based on Kalbach-Mann systematics to compute the energy and angle distributions of recoil nuclei. The energy-angle distributions for recoil nuclei and outgoing particles are written out in the new ENDF/B File 6 format. The result is a complete set of nuclear data that can be used to calculate displacement-energy production, heat production, gas production, transmutation, and activation. Sample results for iron are given and compared to the results of conventional damage models such as those used in NJOY

  11. Damage assessment of nuclear containment against aircraft crash

    Energy Technology Data Exchange (ETDEWEB)

    Iqbal, Mohd Ashraf, E-mail: iqbal_ashraf@rediffmail.com; Sadique, Md. Rehan, E-mail: rehan.sadique@gmail.com; Bhargava, Pradeep, E-mail: bhpdpfce@iitr.ac.in; Bhandari, N.M., E-mail: nmbcefce@iitr.ac.in

    2014-10-15

    Highlights: • Damage assessment of nuclear containment is studied against aircraft crash. • Four impact locations have been identified at the outer containment shell. • The mid of the total height has been found to be most vulnerable location. • The crown of dome has been found to be the strongest location. • Phantom F4 caused more localized and severe damage compared to other aircrafts. - Abstract: The behavior of nuclear containment structure has been studied against aircraft crash with an emphasis on the influence of strike location. The impact locations identified on the BWR Mark III type nuclear containment structure are mid-height, junction of dome and cylinder, crown of dome and arc of dome. The containment at each of the above locations has been impacted normally by Phantom F-4, Boeing 707-320 and Airbus A320 aircrafts. The loading of the aircraft has been assigned through the corresponding reaction-time response curve. ABAQUS/Explicit finite element code has been used to carry out the three-dimensional numerical simulations. The concrete damaged plasticity model was used to simulate the behavior of concrete while the behavior of steel reinforcement was incorporated using the Johnson–Cook elasto-viscoplastic material model. The mid-height of containment has been found to experience most severe deformation against each aircraft. Phantom F4 has been found to be most disastrous at each location. The results have been compared with those of the available studies with respect to the containment deformation.

  12. Risk in Nuclear Industry. Liability for Nuclear Damage. Status of the Problem in the Russian Federation

    International Nuclear Information System (INIS)

    Kovalevich, Oleg M.; Gavrilov, Sergey D.; Voronov, Dmitry B.

    2001-01-01

    Russia is one of a few nuclear power states obtaining the whole number of nuclear fuel cycle (NFC) components - from mining of uranium and on-site electricity production, from NPP spent nuclear fuel processing and extracted fissile materials and radionuclides, which are available in industry, in medicine and in other relevant areas, to radioactive waste processing and disposal. For this reason it is very important to solve the problem of nuclear fuel cycle safety as it is a single system task with an adequate approach for all cycle components. The problem is that NFC facilities are technologically various and refer to different industries (mining, machinery engineering, power engineering, chemistry, etc.). Besides, the above facilities need the development of various scientific bases. The most NFC facilities is directly connected with peaceful use of nuclear energy and with military nuclear industry, as the defense orders stimulated the development of NFC. The specific attention to safety problems at the beginning of nuclear complex foundation adversely affected the state attitude towards the risk in nuclear industry, it has left the traces at present. In our paper we touch upon the problems of risk and the liability for nuclear damage for the third persons. The problems of nuclear damage compensation for nuclear facilities personnel and for the owners (operating organizations) are beyond our subject

  13. Station blackout core damage frequency in an advanced nuclear reactor

    International Nuclear Information System (INIS)

    Carvalho, Luiz Sergio de

    2004-01-01

    Even though nuclear reactors are provided with protection systems so that they can be automatically shut down in the event of a station blackout, the consequences of this event can be severe. This is because many safety systems that are needed for removing residual heat from the core and for maintaining containment integrity, in the majority of the nuclear power plants, are AC dependent. In order to minimize core damage frequency, advanced reactor concepts are being developed with safety systems that use natural forces. This work shows an improvement in the safety of a small nuclear power reactor provided by a passive core residual heat removal system. Station blackout core melt frequencies, with and without this system, are both calculated. The results are also compared with available data in the literature. (author)

  14. The Brussels I Regulation and Liability for Nuclear Damage

    International Nuclear Information System (INIS)

    Handrlica, J.

    2010-01-01

    Prior to 2004, the map of the European Union seemed to be basically identical to the map of the contracting parties to the Paris Convention on Third Party Liability in the Field of Nuclear Energy of 1960 ('the Paris Convention'). The 2004 and 2007 enlargements were mainly composed of the contracting parties to the Vienna Convention on Civil Liability for Nuclear Damage of 1963 ('the Vienna Convention'). In various discussions, the term 'nuclear liability patchwork' is used to describe this existing situation. One of the problems arising from this 'patchwork' is that, while a uniform legal framework was established for matters of jurisdiction and the enforcement of decisions under the authority given to the European Union ('EU') by the Council Regulation on jurisdiction and the recognition and enforcement of judgements in civil and commercial matters ('Brussels Regulation'), this overall framework does not apply to particular matters governed by the special conventions to which member states may be contracting parties, see Article 71 of the Brussels Regulation. This paper aims to outline the 'patchwork' of these rules that are applicable to nuclear third party liability cases in the EU and to point out the main consequences arising from this legal framework difficult to comprehend.5 Its scope, however, is limited to the legal issues arising from a nuclear incident occurring in a nuclear installation situated within the territory of the European Union

  15. Terrorism cover in France for property damage including nuclear risks

    International Nuclear Information System (INIS)

    Stanislas, A.

    2004-01-01

    The obligation to include terrorism cover in all Property Damage policies issued on the French Market is ruled by an Act of 1986 and introduced under Section R 126-2 of the French Code of Insurance. This section stipulates that Property Damage policies must provide cover for damage resulting from acts of terrorism, with the same deductible and the same limit than that of the other damage covered in the policy. Soon after the dramatic events of September 11, 2001 in the United States and although reinsurers worldwide restricted their offer of capacities, French insurers recognized that they had to maintain this global cover for the benefit of their insurers. After difficult discussions between insurers, reinsurers, brokers, risk managers and representatives of the State, the creation of a new Pool, backed with a State guarantee, was decided in less than three months. Effective January 1, 2002 and called Gestion d'Assurance et de Reassurance des Risques Attentats et Actes de Terrorisme (GAREAT), the Pool offers a multiple layers stop-loss cover for Property Damage only, i.e. excluding TPL policies. Considering that nuclear risks should be treated in the same way as other industrial risks, it was decided that they would be covered by GAREAT as well. In the meantime, by a Decree of December 28, 2001 modifying Section R 126-2, a special provision, aiming at reducing the limit and thus the price of this cover, was introduced in the Code. The purpose of this paper is to expose the present situation applying through GAREAT and, after two years of operation to discuss future developments, including other sources of capacity for the coverage of acts of terrorism in nuclear risks insurance.(author)

  16. Indemnification for nuclear damages - recent developments in the United States

    International Nuclear Information System (INIS)

    Shapar, H.K.

    1981-10-01

    Public liability for nuclear damages in the United States is dealt with by a Federal statutory system. The Price-Anderson Act provides a system of compensation for such damages with an overall limit of $560 million. This fund is composed of private insurance, a utility assessment pool, and Federal government indemnity. The 1979 accident at the Three Mile Island nuclear station resulted in a less-than-full-scale test of the system. For the most part, the system has performed as intended although certain problems have been brought to light. Legislative proposal since the accident have focused on increasing the $560 million limitation on liability, but so far none of these proposals has been acted upon by the U.S. Congress. In the next several years, the Nuclear Regulatory Commission and possibly Congress will consider application of the Price-Anderson system to high-level waste facilities. The Commission must file with the Congress within two years a comprehensive report on the Price-Anderson Act, including recommendations for its continuation and amendment. (NEA) [fr

  17. Prevention of damage and 'residual risk' in nuclear power laws

    International Nuclear Information System (INIS)

    Greipl, C.

    1992-01-01

    The concept of prevention of damage within the framework of nuclear power laws includes averting danger for the protection of third parties and preventing risks for the partial protection of third parties with the proviso that still a desire to use the concept 'residual risk' in addition, it should be limited, on the grounds of what can be reasonably expected, to those risks which cannot be reduced any further by the government, i.e. to risks which the public in general and third parties ('actually') must accept. In the future, questions regarding safety systems should be taken into account exclusively withing the context of 'what is necessary for protection against damage in keeping with the latest developments in science and technology' and not at the discretion of the law in denying permission according to Article 7 Paragraph 2 Atomic Energy Law. (orig.) [de

  18. Protocol to amend the Vienna convention on civil liability for nuclear damage. Convention on supplementary compensation for nuclear damage. Final act

    International Nuclear Information System (INIS)

    1998-01-01

    The document reproduces the Final Act of the Diplomatic Conference held in Vienna between 8-12 September 1997 which adopted the Protocol to Amend the Vienna Convention on Civil Liability for Nuclear Damage, and the Convention on Supplementary Compensation for Nuclear Damage

  19. Protocol to amend the Vienna convention on civil liability for nuclear damage. Convention on supplementary compensation for nuclear damage. Final act

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-07-23

    The document reproduces the Final Act of the Diplomatic Conference held in Vienna between 8-12 September 1997 which adopted the Protocol to Amend the Vienna Convention on Civil Liability for Nuclear Damage, and the Convention on Supplementary Compensation for Nuclear Damage

  20. 75 FR 64717 - Convention on Supplementary Compensation for Nuclear Damage Contingent Cost Allocation

    Science.gov (United States)

    2010-10-20

    ... DEPARTMENT OF ENERGY Convention on Supplementary Compensation for Nuclear Damage Contingent Cost... Supplementary Compensation for Nuclear Damage (``CSC'') including its obligation to contribute to an international supplementary fund in the event of certain nuclear incidents. The NOI provided a September 27...

  1. Legislative Study on China’s Compensation for Nuclear Damage Liability

    Directory of Open Access Journals (Sweden)

    Jiu Liu

    2018-06-01

    Full Text Available The civil nuclear industry plays an important role in improving environmental quality and safeguarding energy security in China. Nevertheless, the industry is facing a huge risk of nuclear accident damage. The legal system of nuclear damage compensation is of vital importance for the industry to address potential risks. The Nuclear Safety Law, which has recently been published in China, stipulates two articles about nuclear damage compensation in principle. However, in general, the current nuclear damage compensation legal system in China has not yet been made systematic and there are still problems, such as a lack of maneuverability and details. This paper adopts qualitative and quantitative methodologies to summarize and analyze the current legislation and regulation pertaining to civil nuclear damage compensation liability in China and analyzes the shortages and deficiencies of these rules in detail by using legal analysis methods. Suggestions to establish and perfect China’s legal system of nuclear damage compensation are proposed to safeguard the healthy development of the civil nuclear industry and remedy damages brought about by nuclear accidents. Such a legal system should contain the elements of clear legislative goals and objectives, a specific definition and scope of nuclear damage, strict and sole responsibility principles for operators, an appropriate liability amount, a stable financial guarantee for operators, and national supplementary liability.

  2. Nuclear oxidative damage correlates with poor survival in colorectal cancer.

    LENUS (Irish Health Repository)

    Sheridan, J

    2012-02-01

    Oxidative DNA damage results from DNA adducts such as 8-oxo-7, 8 dihydro-2\\'-deoxyguanosine (8-oxo-dG), which is a pro-mutagenic lesion. No known association between 8-oxo-dG, disease progression and survival exists in colorectal cancer (CRC). We examined levels of 8-oxo-dG in sporadic CRC to determine its relationship with pathological stage and outcome. A total of 143 CRC patients and 105 non-cancer patients were studied. Nuclear and cytoplasmic 8-oxo-dG was assessed using immunohistochemistry. Double immunofluorescence using 8-oxo-dG and manganese superoxide dismutase (MnSOD) antibodies localised cytoplasmic 8-oxo-dG. Apoptosis was detected using TUNEL. Nuclear staining levels were similar in tumour tissue and matched normal mucosa in both epithelial (P=0.22) and stromal (P=0.85) cells. Epithelial cytoplasmic staining was greater in tumour tissue (P<0.001). Double immunofluorescence localised cytoplasmic 8-oxo-dG to mitochondria. Epithelial and stromal nuclear 8-oxo-dG decreased with local disease spread, but highest levels were found in distant disease (P<0.01). Survival was related to epithelial nuclear and stromal staining in normal mucosa (P<0.001) and tumour (P<0.01) but was unrelated to cytoplasmic staining. Normal control cells in tissue from cancer patients with high levels of 8-oxo-dG failed to undergo cell death. 8-oxo-dG may be an important biomarker of disease risk, progression and survival for CRC patients.

  3. Research on spatial Model and analysis algorithm for nuclear weapons' damage effects

    International Nuclear Information System (INIS)

    Liu Xiaohong; Meng Tao; Du Maohua; Wang Weili; Ji Wanfeng

    2011-01-01

    In order to realize the three dimension visualization of nuclear weapons' damage effects. Aiming at the characteristics of the damage effects data, a new model-MRPCT model is proposed, and this model can carry out the modeling of the three dimension spatial data of the nuclear weapons' damage effects. For the sake of saving on the memory, linear coding method is used to store the MRPCT model. On the basis of Morton code, spatial analysis of the damage effects is completed. (authors)

  4. Ukraine. Law on civil liability for nuclear damage and its financial security (13 december 2001)

    International Nuclear Information System (INIS)

    Anon.

    2002-01-01

    The objective of this law is to regulate civil liability for the compensation of damage resulting from activities involving the utilisation of nuclear energy for peaceful purposes. It governs relations in respect of civil liability for nuclear damage, establishes the rules and procedures for compensation for damage caused by a nuclear incident, defines the methods of ensuring financial security of civil liability and establishes its limits. (N.C.)

  5. The amendment of the law on compensation for nuclear damage in Japan

    International Nuclear Information System (INIS)

    Tanikawa, H.

    2000-01-01

    The legal regime relating to the compensation for nuclear damage in Japan is governed by 'the Law on Compensation for Nuclear Damage' and the 'Law on indemnity Agreement for Compensation of Nuclear Damage'. The basic liability scheme on compensation for nuclear damage in the Compensation law is constituted on the basis of strict and unlimited liability, and such liability is channeled to a nuclear undertaker who is engaged on the operation of the reactor, etc.Furthermore, in order to operate a reactor a nuclear undertaker has to have provided financial security for compensation of nuclear damage by means of contracts, for liability insurance in respect of potential nuclear damage and an indemnity agreement for compensation of nuclear damage or the deposit. In addition to this financial security, in the event that nuclear damage occurs, and if necessary, the Government shall give to a nuclear undertaker such aid as required for him to compensate the nuclear damage. The financial security amount specified in the compensation Law has been increased to JPY (Japan yen) 60 billion. The necessity for special requirements in relation to financial security and/or the level of its amount in case of decommissioning of reactors, storage of nuclear spent fuel outside the power plant, radioisotopes other than nuclear fuel materials, or high level waste of nuclear fuel material, or the operation of experimental reactors for nuclear fusion, etc. shall be examined in the near future according to developments made in this field and the corresponding necessity for financial security for each case. (N.C.)

  6. Present status and prospects of the compensation system for nuclear damage in China

    International Nuclear Information System (INIS)

    Zhou, Z.; Liu, C.

    1993-01-01

    In handling liability for nuclear damage matters, China currently adheres to the rules stipulated in the administrative legal document regarding liability to third parties for nuclear damage enacted by the State Council, in which it is defined that the principles of absolute liability, limitation of liability and single competent court are applicable in China. The Chinese government shall enact state laws on liability for nuclear damage on the basis of the above-mentioned legal document and with active consideration of the function of the state in the compensation for nuclear damage

  7. Legal analysis at the Law for Civil liabilities by nuclear damage

    International Nuclear Information System (INIS)

    Gonzalez G, A.

    2000-01-01

    The present work has the objective to analyse in specific terms the legal regime of the Civil liability by nuclear damage. It has been the intention of that this compilation is the initiation of a large way which awake the interests of jurists and specialists dedicated to study the aspects as the liability by nuclear damage, compensation guarantee, risk and nuclear damage among others. The peaceful applications of the nuclear energy require the necessity of a legal ordinance that it is updated according to the nuclear technology development that the regulations of the common law do not cover. This work is initiated mentioning some antecedents of the nuclear energy law in Mexico. Also is realized the study of the elemental concepts and definitions about the subject as the evolution of the legal figure in the National law frame where the jurist must do an incursion in the nuclear field and make use of scientific and technical terminology. It was analysed and it was made the reflection of the legal figure of liability, its exoneration cases, about the concepts of risk and nuclear damage overcoming the conceptual error among them. It is talked about the study of nuclear damage and its repairing as financial guarantee to compensate to the people injured by a nuclear accident. Finally, it was treated about the legal analysis and proposals of additions and reforms for updating the Nuclear damage liability Law, concluding with general contributions to the Law resulting products of this work. (Author)

  8. Fatigue damage of nuclear facilities; Endommagement par fatigue des installations nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-07-01

    The conference on the fatigue damage of nuclear facilities, organized by the SFEN (french society of nuclear energy), took place at Paris the 23. of november 2000. Eleven papers were presented, showing the state of the art and the research programs in the domain of the sizing rules, safety, installations damage, examination and maintenance. (A.L.B.)

  9. Just and reasonable distribution of funds for limited damages in the event of nuclear disasters

    International Nuclear Information System (INIS)

    Schattke, H.

    1985-01-01

    A suggestion is made to make legal dispositions for the distribution of funds before a nuclear event. The concept incorporates the following material-legal elements: Proportionate reduction of damages compensation claims in case the funds for liability and coverage are insufficient; creation of reserve funds for late damage; legal preference of personal damage and only subsequent satisfaction of demand for compensation of nuclear industries. (orig.) [de

  10. Nuclear energy: liability for damage to the environment according to the National Environmental Law

    International Nuclear Information System (INIS)

    Eiras, Sergio Alves; Couto, Roberto Toscano

    1995-01-01

    Liability for damage of the environment is the kind of subject which arouses heated debates in the nuclear energy field among the jurists. Brazil lacks a specific environmental law upon which settlement on questions of nuclear damage could be based. In spite of such lackness, considerable progress has been achieved with the obligatory elaboration of the Environmental Impact Assessment (EIA), the constitutional rules establishing competence and responsibilities on this matter, and some scattered laws. The objective of this work is to focus the responsibility of the Union that exercised the monopoly of nuclear activities, its agents and the team of experts which elaborate the EIA as well as the damage to the environment from a nuclear accident. This study is based on the legal definitions of nuclear reactor, radioactive waste and product, radioisotope, among others. It also focuses some proposed amendments of the law regulating both the civil and criminal liabilities for nuclear damage. (author). 7 refs

  11. Safety technical investigation activities for shipment of damaged spent fuels from Fukushima Daiichi Nuclear Power Station

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-08-15

    Japan Nuclear Energy Safety Organization(JNES) carries out the investigation for damaged fuel transportation from Fukushima Daiichi Nuclear Power Station(1F) under safety condition to support Nuclear Regulation Authority (NRA). In 2012 fiscal year, JNES carried out the investigation of spent fuel condition in unit 4 of 1F and actual result of leak fuel transport in domestic /other countries. From this result, Package containing damaged fuel from unit 4 in 1F were considered. (author)

  12. New tendencies in the legal mark give the civil liability for nuclear damages

    International Nuclear Information System (INIS)

    Gil Portela, Rosario; Alonso Gonzalez, Ivonne

    1998-01-01

    The development gives an indispensable legal mark for the execution a nuclear program it includes relative special dispositions to the civil liability for nuclear damages. The existence gives an international regime in this matter and its current improvement, give the one that Cuba is State it leaves, it conditions the inclusion additional requirements in the national legislative system on civil liability relatives to the possible damages that it could cause to the personal one and environment in general a nuclear accident

  13. Radiation damage studies related to nuclear waste forms

    International Nuclear Information System (INIS)

    Gray, W.J.; Wald, J.W.; Turcotte, R.P.

    1981-12-01

    Much of the previously reported work on alpha radiation effects on crystalline phases of importance to nuclear waste forms has been derived from radiation effects studies of composite waste forms. In the present work, two single-phase crystalline materials, Gd 2 Ti 2 O 7 (pyrochlore) and CaZrTi 2 O 7 (zirconolite), of relative importance to current waste forms were studied independently by doping with 244 Cm at the 3 wt % level. Changes in the crystalline structure measured by x-ray diffraction as a function of dose show that damage ingrowth follows an expected exponential relationship of the form ΔV/V 0 = A[1-exp(-BD)]. In both cases, the materials became x-ray amorphous before the estimated saturation value was reached. The predicted magnitudes of the unit cell volume changes at saturation are 5.4% and 3.5%, respectively, for Gd 2 Ti 2 O 7 and CaZrTi 2 O 7 . The later material exhibited anisotropic behavior in which the expansion of the monoclinic cell in the c 0 direction was over five times that of the a 0 direction. The effects of transmutations on the properties of high-level waste solids have not been studied until now because of the long half-lives of the important fission products. This problem was circumvented in the present study by preparing materials containing natural cesium and then irradiating them with neutrons to produce 134 Cs, which has only a 2y half-life. The properties monitored at about one year intervals following irradiation have been density, leach rate and microstructure. A small amount of x-ray diffraction work has also been done. Small changes in density and leach rate have been observed for some of the materials, but they were not large enough to be of any consequence for the final disposal of high level wastes

  14. The new definition of nuclear damage in the 1997 protocol to amend the 1963 vienna convention on civil liability for nuclear damage

    International Nuclear Information System (INIS)

    Soljan, V.

    2000-01-01

    This communication analyzes the content and the impact of the new definition of nuclear damage contented in the amendment protocol of the Vienna Convention relative to the civil liability in the 1963 Convention. Having in mind the experience of the Three Mile Island and Chernobyl accidents, it is demonstrated that the costs of preventive measures, damage to the environment and economic loss may constitute substantial portions of the total damage following a nuclear accident. Then, the new definition is studied in detail, on insisting on the notion of economic loss. A development is devoted to the question of damage to the environment. The preventive measures are studied and their conditions of the compensation receivability evoked with the criteria of reasonable measures. (N.C.)

  15. Aging and oxidatively damaged nuclear DNA in animal organs

    DEFF Research Database (Denmark)

    Møller, Peter; Løhr, Mille; Folkmann, Janne K

    2010-01-01

    Oxidative stress is considered to contribute to aging and is associated with the generation of oxidatively damaged DNA, including 8-oxo-7,8-dihydroguanine. We have identified 69 studies that have measured the level of oxidatively damaged DNA in organs of animals at various ages. In general, organs...... with limited cell proliferation, i.e., liver, kidney, brain, heart, pancreas, and muscle, tended to show accumulation of DNA damage with age, whereas organs with highly proliferating cells, such as intestine, spleen, and testis, showed more equivocal or no effect of age. A restricted analysis of studies...... evidence for aging-associated accumulation of oxidatively damaged DNA in organs with limited cell proliferation....

  16. Nuclear damage under the 1997 protocol: conventional thinking?

    International Nuclear Information System (INIS)

    Warren, G.

    2000-01-01

    This communication expresses the critical point of view of nuclear insurers about the international civil liability system and tackles questions about the current revision of this system. After having examined the nuclear risk nature in the insurance point of view and remind the objective of nuclear conventions in this context, the author expresses the opinion that compensation means, planned by these conventions, can be suitable to limited nuclear accident but would be insufficient to face the consequences of a serious nuclear accident. (N.C.)

  17. Ecological impacts and damage - comparison of selected components for nuclear and conventional power plants (example of Mochovce nuclear power plant)

    International Nuclear Information System (INIS)

    Bucek, M.

    1984-01-01

    A comparison is given of ecological damage for the nuclear power plant in Mochovce and a conventional power plant with the same power. Ecological effects and damage are divided into three groups: comparable damage, ecological damage caused only by conventional power plants and ecological damage caused only by nuclear power plants. In the first group the factors compared are land requisition, consumption of utility water and air consumption. In the second group are enumerated losses of crops (cereals, sugar beet, potatoes, oleaginous plants) and losses caused by increased disease rate owing to polluted environment by conventional power plants. In the third group health hazards are assessed linked with ionizing radiation. Also considered are vent stack escapes. (E.S.)

  18. Nur77 forms novel nuclear structures upon DNA damage that cause transcriptional arrest

    International Nuclear Information System (INIS)

    Leseleuc, Louis de; Denis, Francois

    2006-01-01

    The orphan nuclear receptor Nur77 has been implicated in both growth and apoptosis, and its function and activity can be modulated by cellular redistribution. Green fluorescent protein-tagged Nur77 was used to evaluate the role of Nur77 intracellular redistribution in response to genotoxic stress. Selected DNA damaging agents and transcription inhibition lead to rapid redistribution of Nur77 into nuclear structures distinct from conventional nuclear bodies. These nuclear bodies formed transiently were tightly bound to the nuclear matrix and conditions that lead to their appearance were associated with Nur77 transcriptional inhibition. The formation of Nur77 nuclear bodies might be involved in programmed cell death modulation upon exposure to DNA damaging agents that inhibit transcription by sequestrating this proapoptotic factor in dense nuclear structures

  19. Legal responsibility for damage caused by nuclear accidents

    International Nuclear Information System (INIS)

    Brink, J.J. van den.

    1986-04-01

    In this essay a treatment is given of the legal third-party risks of licencees of nuclear power plants. It is regarded to what extent the actual responsibility arrangements provide an adequate protection to the citizen against potential risks of a nuclear power plant. (Auth.)

  20. New national legislation on compensation of nuclear damage

    International Nuclear Information System (INIS)

    Guerra Machado de Faria, N.

    1981-10-01

    This paper describes the nuclear third party liability system within the Brazilian legal framework. Following some considerations regarding the development of nuclear energy it then focuses on the relationship between accident prevention and third party liability and on the political administrative framework related to the nuclar industry in Brazil. (NEA) [fr

  1. Through the looking glass: placing India's new civil liability regime for nuclear damage in context

    International Nuclear Information System (INIS)

    Gruendel, Robert J.; Kini, Els Reynaers

    2012-01-01

    Until India adopted the Civil Liability for Nuclear Damage Act, 2010 (Liability Act) and the Civil Liability for Nuclear Damage Rules, 2011 (Liability Rules or Rules), no specific legislation was in place to govern nuclear liability or to compensate victims for damages due to a nuclear incident in India. Before delving into a more legal-technical analysis of the Liability Act and Rules (Part B), it is worth first briefly touching upon India's general energy situation, which necessarily influences India's policies, laws and negotiating strategies while also driving the significant business opportunities in the nuclear energy sector (Part A). Taking a look at India's energy sector today also underscores the sheer size of India's plans to build new nuclear power plants, which stands in dramatic contrast to the goals of many other countries. In this article, we will address the relationship of the Liability Act with the Convention on Supplementary Compensation for Nuclear Damage (CSC) (Part C), while also touching upon the current status of an Indian nuclear insurance pool (Part D) and discussing some recent domestic developments, including the filing of public interest litigations and amendments to the Liability Rules (Part E), before presenting some concluding thoughts (Part F)

  2. Concrete alkali-silica reaction and nuclear radiation damage

    International Nuclear Information System (INIS)

    Ichikawa, Tsuneki

    2008-01-01

    The deterioration of concrete by alkali-silica reaction of aggregates (ASR) and the effect of nuclear radiations on the ASR have been reviewed based on our studies on the mechanism of ASR and the effect of nuclear radiations on the resistivity of minerals to alkaline solution. It has been found that the ASR is initiated by the attack of alkaline solution in concrete to silicious aggregates to convert them into hydrated alkali silicate. The consumption of alkali hydroxide by the aggregates induces the dissolution of Ca 2+ ions into the solution. The alkali silicate surrounding the aggregates then reacts with Ca 2+ ions to convert to insoluble tight and rigid reaction rims. The reaction rim allows the penetration of alkaline solution but prevents the leakage of viscous alkali silicate, so that alkali silicate generated afterward is accumulated in the aggregate to give an expansive pressure enough for cracking the aggregate and the surrounding concrete. The effect of nuclear radiation on the reactivity of quartz and plagioclase, a part of major minerals composing volcanic rocks as popular aggregates, to alkaline solution has been examined for clarifying whether nuclear radiations accelerates the ASR. It has been found that the irradiation of these minerals converts them into alkali-reactive amorphous ones. The radiation dose for plagioclase is as low as 10 8 Gy, which suggests that the ASR of concrete surrounding nuclear reactors is possible to be accelerated by nuclear radiation. (author)

  3. Nuclear Reaction Data and Uncertainties for Radiation Damage. Summary Report of the Technical Meeting

    International Nuclear Information System (INIS)

    Griffin, P.J.; Sjöstrand, H.; Simakov, S.P.

    2016-08-01

    This Meeting was organized to implement the recommendation of the second Research Coordinated Meeting (RCM) of the International Atomic Energy Agency (IAEA) Coordinated Research Project (CRP) “Primary Radiation Damage Cross Sections” to analyse the accuracy and consistency of the radiation damage-relevant nuclear data in the major nuclear data evaluations with the eventual goal of identifying the most reliable data and providing quantitative uncertainty estimates. Participants have considered the status of the primary nuclear data, such as reaction recoils spectra in the latest releases of ENDF, JEFF, JENDL, FENDL, ROSFOND and TENDL nuclear data libraries, and the ways of deriving the damage quantities KERMA, NRT- or arc-dpa and gas production cross sections as well as the recipes for an assessment of their uncertainties. This report contains the contemporary view of the Meeting participants on these issues in the form of a consolidated set of statements, recommendations and individual summaries. (author)

  4. Tornado damage at the Grand Gulf, Mississippi nuclear power plant site: aerial and ground surveys

    International Nuclear Information System (INIS)

    Fujita, T.T.; McDonald, J.R.

    1978-05-01

    A tornado struck the Grand Gulf nuclear power generating station, Port Gibson, Mississippi, about 11:30 p.m. on April 17, 1978. Storm damage investigators from the University of Chicago and Texas Tech University were dispatched to survey the damage. The meteorological situation that spawned the Grand Gulf tornado and seven others in the area is discussed. Aerial surveys of the entire damage path and detailed surveys of the plant site are presented. An engineering evaluation of the damage is also presented based primarily on information gained from detailed ground surveys

  5. The Indian civil liability for nuclear damage act, 2010. Legislation with flaws?

    International Nuclear Information System (INIS)

    Pelzer, Norbert

    2011-01-01

    1. India has had no special legislation so far about liability under civil law for nuclear damage. Instead, the general law about damages outside of contractual provisions applied. 2. The ambitious Indian civil nuclear program requires intensified international cooperation. The potential partners in that cooperation demand that liability regulations be adopted on the basis of the principles of the international nuclear liability conventions so as to grant legal assurance to their export industries. 3. In May 2010, draft liability legislation was introduced into the Indian parliament. Final deliberations were held on August 30, 2010. On September 21, 2010, the President confirmed the draft legislation, thereby making it law. The draft legislation had been a matter of dispute in India from the outset. 4. The law applies to nuclear facilities owned or controlled by the Indian central government. Only the government or government institutions or state-owned companies can be owners of a nuclear facility. The owner is liable without fault having to be proven. The details of liability follow the provisions of the liability conventions. 5. The law provides for legal channelling of liability to the owner of a nuclear facility. 6. Regular courts of law have no competence to rule about claims for damages under the law. Instead, a 'Claims Commissioner' appointed ad hoc by the government, or a 'Nuclear Claims Commission,' are competent. 7. The 2010 Indian nuclear liability law is a piece of legislation with deficiencies. Key elements are incompatible with the principles of international nuclear liability regimes. (orig.)

  6. The order for enforcing the law on indemnity agreement for compensation of nuclear damage

    International Nuclear Information System (INIS)

    1977-01-01

    The states to be specified by the cabinet order stipulated in Item 2, Article 3 to the Law on Indemmity Agreement for Compensation of Nuclear Damage (hereinafter referred to as the Law) are the states meeting the following requirements. There are no violation of the stipulations according to the specified articles of the Law for the Regulation of Nuclear Source Materials, Nuclear Fuel Materials and Reactors, no damage of the facilities provided for the operation of reactors and others, and no natural calamity or no action of third parties which become the causes for the occurrence of nuclear damage. The nuclear damage to be specified according to the cabinet order stipulated in No. 5, Article 3 of the Law is the one caused by tidal waves. The indemnification rate stipulated in Article 6 of the Law to be decided by the cabinet order is 5/10000 (and 2.5/10000 regarding the indemnification contract with universities or colleges). Atomic energy entrepreneurs should notify the specified items to the Government with reference to the indemnification contracts concerning the operation of reactors, fabrication, reprocessing, use and transportation of nuclear fuel materials or matters contaminated by nuclear fuel materials

  7. Deliberations on Compensation and Remediation of Nuclear Damage to the Environment

    International Nuclear Information System (INIS)

    Pelzer, N.

    2010-01-01

    At its meeting held on 17 and 18 November 2009, the OECD NEA's Nuclear Law Committee (NLC) discussed the issue of obtaining financial security to cover liability for environmental damage. The experts from the insurance industry observed that the liability for environmental damage under the '2004 Paris Convention on Third Party Liability in the Field of Nuclear Energy' (2004 Paris Convention)2 may differ from the liability established under the 'Directive 2004/35/EC of the European Parliament and of the Council of 21 April 2004 on environmental liability with regard to the prevention and remedying of environmental damage' (referred to as 'directive'). This discussion put into focus the question whether the term 'liability' of the operator under the 2004 Paris Convention and under the directive covers identical concepts of 'compensation'. It is true that the directive, according to its Article 4, excludes nuclear risks or environmental damage or the imminent threat of such damage originating from defined nuclear activities from its scope of application. However, it reserves the right to amend that exclusion by 2014 [Article 18(2) and (3)]. Irrespective of this legal situation, there exists an understandable interest of the insurance industry and of other stakeholders as well to get clarification on which type of obligation the operator has to meet under both instruments, or in other words: which liability and coverage consequences does damage to the environment entail for the operator?

  8. Possible genetic damage in the Czech nuclear powe plant werkers

    Czech Academy of Sciences Publication Activity Database

    Šrám, Radim; Rössner st., Pavel; Rubeš, J.; Beskid, Olena; Dušek, Zdík; Chvátalová, Irena; Schmuczerová, J.; Milcová, Alena; Solanský, I.; Bavorová, H.; Očadlíková, D.; Kopečná, O.; Musilová, P.

    2006-01-01

    Roč. 593, 1-2 (2006), s. 50-63 ISSN 0027-5107 R&D Projects: GA MŽP SL/5/160/05 Institutional research plan: CEZ:AV0Z50390512 Keywords : nuclear power plant * chromosomal aberrations * occupational risk Subject RIV: DN - Health Impact of the Environment Quality Impact factor: 4.111, year: 2006

  9. Risks and benefits of the interventions aimed at minimizing nuclear damage in the Chernobyl accident

    International Nuclear Information System (INIS)

    Rossiello, L.A.; Failla, L.

    1997-01-01

    The damages that the absorption of ionizing radiation (i.r.) can cause to humans may be classified as 1) nonstochastic (somatic or deterministic) or 2) stochastic (probabilistic) , which result, for example, from high doses of i.r. absorbed after a serious nuclear accident. Though the Chernobyl case involved both kinds of damage, this paper deals only with stochastic damage risk, and confine our considerations to individuals who were directly Affected and received high i.r. doses. The purpose of this paper is to provide elements on which to base future decisions on the evacuation and return of populations affected by serious nuclear accidents. Unlike the abundant literature on the subject, and as a necessary complement thereto within the bounds of a strict synthesis, to identify the most significant parameters applicable to single individuals rather than to the population at large, and referring solely to risks of stochastic damage

  10. Assessment of seismic damages in nuclear power plant buildings

    International Nuclear Information System (INIS)

    Corsanego, A.; DelGrosso, A.; Ferro, G.

    1987-01-01

    Performance of nuclear power plant sites, buildings and components is in today's practice continuously evaluated by means of monitoring systems composed by a variety of instruments, allowing records of the most significant behavioral parameters to be gathered by electronic data acquisition equipment. A great emphasis has been devoted in recent years to the development of ''intelligent'' monitoring systems able to perform interpretation of the response of structures and components automatically, only requiring human intervention and sophisticated data processing techniques when degradation of the safety margins is likely to have been produced. Such computerized procedures can be formulated through logic or algorithmic processes and normally are consistently based upon simplified, heuristic behavioral models and probabilistic reasoning schemes. This paper is devoted to discuss the development of an algorithmic procedure intended for automatic, real-time interpretation of the recorded response of nuclear power plant buildings and foundations during seismic events

  11. International conventions on civil liability for nuclear damage. Revised 1976 ed.

    International Nuclear Information System (INIS)

    1976-01-01

    This revised edition contains the texts of the following multilateral conventions and instruments concerning civil liability for nuclear damage: The Vienna Convention of 21 May 1963 on Civil Liability for Nuclear Damage; The Paris Convention of 29 July 1960 on Third Party Liability in the Field of Nuclear Energy (incorporating the provisions of the Additional Protocol of 28 January 1964); The Brussels Convention of 31 January 1963; Supplementary to the Paris Convention of 29 July 1960 (and incorporating the provisions of the Additional Protocol signed in Paris on 28 January 1964); and the Brussels Convention of 25 May 1962 on the Liability of Operators of Nuclear Ships. Final Act and Resolutions of the International Conference on Civil Liability for Nuclear Damage, held in Vienna from 29 April to 19 May 1963; Final Act of the International Legal Conference on Maritime Carriage of Nuclear Substances, held in Brussels from 29 November to 2 December 1971; and Convention Relating to Civil Liability in the Field of Maritime Carriage of Nuclear Material, adopted at Brussels on 17 December 1971

  12. Liability for nuclear damage: an international perspective. Reflections on the revision of the Vienna Convention

    International Nuclear Information System (INIS)

    Lopuski, J.

    1993-01-01

    This book deals with deals of the complex issues of liability and compensation for nuclear damage which have been considered in the course of the work of the IAEA concerning the revision of the Vienna Convention on nuclear liability. It presents, in an orderly way, personal reflections of its author based on his experience gathered in years 1989-1992 when participating in this work. Necessarily it contains in some of its parts references to documents of the IAEA Standing Committee on Nuclear Liability; these documents because of their length could not be reproduced. Consequently these parts may not be fully intelligible for those who have not participated in or closely followed the Committee's work. The IAEA work on liability for nuclear damage was initiated in the wake of the impact made on the world's public opinion by the Chernobyl incident and its transboundary effects; issues of international state liability and full compensation have been raised. But humanitarian ideas have quickly been confronted with cold calculations of the cost of financial protection for victims and an open unwillingness of some nuclear states has been manifested. After three years of discussions no wide consensus could be reached on some basic issues, such as: relationship between international state and civil liability regimes, structure of international legislation, concept of nuclear damage, limits of compensation, role of public funds or jurisdiction. The author presents his approach to these controversial issue, trying to provide at the same time a theoretical outline for the future international legislation on nuclear liability. (author)

  13. Management of severely damaged nuclear fuel and related waste

    International Nuclear Information System (INIS)

    1991-01-01

    This report is concerned primarily with severe fuel damage accidents in large electric power producing reactors such as those in the TMI and Chernobyl plants. It does include, as appropriate, knowledge gained from accidents in other power, research and military reactors. It is believed that the conclusions and recommendations apply to a large extent to severe fuel damage accidents in all types of reactors. The period considered in this publication begins after the initial crisis of an accident has been brought under control. (This initial crisis could be from one day to several weeks after the event, depending on the specific conditions). Accordingly, it is assumed that the plant is shut down, the reactor is under control and decay heat removal is in progress in a stable manner so that attention must be given to cleanup. This report addresses the principles involved in planning, engineering, construction, operation and other activities to characterize, clean up and dispose of the fuel and related waste. The end of the period under consideration is when the fuel and abnormal wastes are packaged either for interim storage or final disposal and activities are started either to restore the plant to service or to establish a safe state from which decommissioning planning can start. 36 refs, 3 figs, 4 tabs.

  14. Data analysis on reducing damage on equipment's available in Malaysian Nuclear Agency

    International Nuclear Information System (INIS)

    Hasif Mohamad; Saipo Bahari Abdul Ratan; Ahmad Firdaus Che Hassan; Mazlipah Mohamed Ramlan; Mohd Hazri Mohd Salleh; Ghazali Bachok

    2010-01-01

    Technical Support Division (BST) in the underlying unit of Instrumentation and Automation Center (PIA), has been entrusted to carry out repair work on the equipment's available at Nuclear Malaysia as well as help rehabilitate and provide advisory services to foreign companies in need of our services. These data taken to determine the cause of damage to seek a solution to reduce damage in future. Tools do get involved are autoclave, Water Distiller, Barometer, Vaccum Pump and Chiller and Freezer. (author)

  15. Draft Federal Act of the Russian Federation 'The Civil Liability for Nuclear Damage and its Financial Security'

    International Nuclear Information System (INIS)

    Lebedeva, Yulia

    2014-01-01

    The use of nuclear power by states in the modern world requires supplements to international law through the development of national legislation on civil liability for nuclear damage and compensation. The situation in the Russian Federation is no exception. Russian law on civil liability for nuclear damage has not fully evolved, and currently, there is no specific law covering liability for nuclear damage, nor is there a law regarding the financial and insurance mechanisms for compensation. Instead, the current laws establish a state system of benefits and compensation for damage to health and property of citizens. Since 1996, Russia has been actively working to develop a draft federal act to cover liability for nuclear damage. A bill was first introduced in the State Duma of the Federal Assembly of the Russian Federation on 16 July 1996, and was originally called 'The Compensation for Nuclear Damage and Nuclear Insurance'. In 1997, the official representative of the Government of the Russian Federation, Head of Russian Federal Inspectorate for Nuclear and Radiation Safety, Yuri Vishnevsky, was appointed to present this bill for discussion in the chambers of the Federal Assembly of the Russian Federation. In September 1998, the State Duma rejected the draft federal act and instead adopted in the first reading a different draft federal act: No. 96700118-2, 'The Civil Liability for Nuclear Damage and its Financial Security' ('the bill'). In this case, the State Duma Committee on Ecology was charged with incorporating the incoming amendments into a final bill and submitting it to the State Duma for a second reading. In 2005, Russia ratified the Vienna Convention on Civil Liability for Nuclear Damage. This ratification required significant amendments to 'The Civil Liability for Nuclear Damage and its Financial Security' bill. But, even though the Russian Federation had not yet ratified the Vienna Convention, the drafters were still careful to take into account the

  16. Ubiquitination of HTLV-I Tax in response to DNA damage regulates nuclear complex formation and nuclear export

    Directory of Open Access Journals (Sweden)

    Marriott Susan J

    2007-12-01

    Full Text Available Abstract Background The HTLV-I oncoprotein, Tax, is a pleiotropic protein whose activity is partially regulated by its ability to interact with, and perturb the functions of, numerous cellular proteins. Tax is predominantly a nuclear protein that localizes to nuclear foci known as Tax Speckled Structures (TSS. We recently reported that the localization of Tax and its interactions with cellular proteins are altered in response to various forms of genotoxic and cellular stress. The level of cytoplasmic Tax increases in response to stress and this relocalization depends upon the interaction of Tax with CRM1. Cellular pathways and signals that regulate the subcellular localization of Tax remain to be determined. However, post-translational modifications including sumoylation and ubiquitination are known to influence the subcellular localization of Tax and its interactions with cellular proteins. The sumoylated form of Tax exists predominantly in the nucleus while ubiquitinated Tax exists predominantly in the cytoplasm. Therefore, we hypothesized that post-translational modifications of Tax that occur in response to DNA damage regulate the localization of Tax and its interactions with cellular proteins. Results We found a significant increase in mono-ubiquitination of Tax in response to UV irradiation. Mutation of specific lysine residues (K280 and K284 within Tax inhibited DNA damage-induced ubiquitination. In contrast to wild-type Tax, which undergoes transient nucleocytoplasmic shuttling in response to DNA damage, the K280 and K284 mutants were retained in nuclear foci following UV irradiation and remained co-localized with the cellular TSS protein, sc35. Conclusion This study demonstrates that the localization of Tax, and its interactions with cellular proteins, are dynamic following DNA damage and depend on the post-translational modification status of Tax. Specifically, DNA damage induces the ubiquitination of Tax at K280 and K284

  17. Economic damage caused by a nuclear reactor accident

    International Nuclear Information System (INIS)

    Baan, P.J.A.

    1988-01-01

    The impacts of a nuclear reactor accident have been estimated for: the public water supply; the use of surface water for sprinkling in agriculture, for industry water supply, recreation, etc.; and fisheries. Contamination of water sources may affect the public water supply severely. In such a situation demand of water cannot always be met. Agriculture faces production losses, if demand for uncontaminated surface water cannot be met. The impacts on recreation can also be significant. The losses to other water users are less substantial. Fisheries may lose (export) markets, as people become reluctant to buy fish and fish products. 33 refs.; 3 figs.; 35 tabs

  18. Fatigue damage in nuclear power plants: cases study

    International Nuclear Information System (INIS)

    Goltrant, O.; Thebault, Y.

    2001-01-01

    Some fatigue cracks have been detected on nuclear power plants components. Generally they appears under local solicitations not correctly predicted. Two cases are presented in this paper to illustrate the problem: the pitting during mechanical fatigue where the stresses are induced by the pumps vibrations or by fluid flow; the mixing zones of RRA circuit (N4 bearing) where the stresses are induced by the flow of different temperature fluids. The examination allowed the identification of the cracking origin and the development of corrective solutions. (A.L.B.)

  19. Yugoslavia-Act on Liability for Nuclear Damage of 19 April 1978

    International Nuclear Information System (INIS)

    Anon.

    1979-01-01

    This Act, which came into force eight days after its publication, is based to a great extent on the provisions of the 1963 Vienna Convention on Civil Liability for Nuclear Damage, ratified by Yugoslavia on 12 August 1977. Under the Act, a nuclear operator is held absolutely liable for any nuclear damage caused by a nuclear indicent occurring in his installation. This liability is limited to 450 million dinars (approximately 22 million US$). To cover his liability, an operator must take out insurance or other financial security, whose amount will be determinated by the competent authority according to the characteristics of the installation involved but in no event should it be below 150 million dinars. Within the meaning of the Act, the operator may be an organisation of associated labour which has obtained site approval, licences for test runs and entry into operation of the installation, or any person recognised as such by the State. (NEA) [fr

  20. Vibration analysis and vibration damage assessment in nuclear and process equipment

    International Nuclear Information System (INIS)

    Pettigrew, M.J.; Taylor, C.E.; Fisher, N.J.; Yetisir, M.; Smith, B.A.W.

    1997-01-01

    Component failures due to excessive flow-induced vibration are still affecting the performance and reliability of process and nuclear components. The purpose of this paper is to discuss flow-induced vibration analysis and vibration damage prediction. Vibration excitation mechanisms are described with particular emphasis on fluid elastic instability. The dynamic characteristics of process and power equipment are explained. The statistical nature of some parameters, in particular support conditions, is discussed. The prediction of fretting-wear damage is approached from several points-of-view. An energy approach to formulate fretting-wear damage is proposed. (author)

  1. Investigation of potential fire-related damage to safety-related equipment in nuclear power plants

    International Nuclear Information System (INIS)

    Wanless, J.

    1985-11-01

    Based on a review of vendor information, fire damage reports, equipment qualification and hydrogen burn test results, and material properties, thirty-three types of equipment found in nuclear power plants were ranked in terms of their potential sensitivity to fire environments. The ranking considered both the functional requirements and damage proneness of each component. A further review of the seven top-ranked components was performed, considering the relative prevalence and potential safety significance of each. From this, relays and hand switches dominate as first choices for fire damage testing with logic equipment, power supplies, transmitters, and motor control centers as future candidates

  2. Liability for damage resulting from acts of the nuclear and radiological terrorism

    International Nuclear Information System (INIS)

    Handrlica, J.

    2008-01-01

    Nuclear terrorism is defined as an attack on a nuclear installation serving peaceful uses (such as a nuclear power plant) or non-peaceful uses. Radiological terrorism, which may be more likely, is defined as an action which doesn't trigger a nuclear reaction but gives rise to the release of radioactivity. The aim of this paper is to analyze the existing legal framework covering such situations. The relevant provisions of the Vienna and Paris Conventions on civil liability for nuclear damage, which represent a legal framework for nuclear liability at the international level, are discussed. The focus is on the identification of the the liable subject, including definition of the scope and nature of its liability. (author)

  3. Entry into force of the Convention on Supplementary Compensation for Nuclear Damage: Opening the umbrella

    International Nuclear Information System (INIS)

    McRae, Ben

    2015-01-01

    There are 431 commercial nuclear power plants around the world. On 14 April 2015, 193 of these power plants were covered by a nuclear liability instrument (118 power plants by the Paris Convention and 75 by the Vienna Convention). With the entry into force of the Convention on Supplementary Compensation for Nuclear Damage (CSC)4 on 15 April 2015, the number of power plants covered by a nuclear liability instrument increased to 340. Thus, the entry into force of the CSC marked a major milestone towards the establishment of a global nuclear liability regime. This article discusses several events that have promoted progress towards a global nuclear liability regime and then addresses several questions that may arise as countries consider actions necessary to achieve such a regime. (author)

  4. The inadequate liability and compensation regime for damage caused by nuclear activities

    International Nuclear Information System (INIS)

    Dyke, Jon M. Van

    2010-09-01

    The specific obligation to provide restitution and compensation when nuclear activities cause injuries has been recognized repeatedly and is now certainly part of customary international law. But problems remain regarding how to measure damages, how to implement the duty to repair the injuries, and what specific obligations exist to protect neighboring states from transboundary pollution. Although some treaties exist governing liability for harm resulting from nuclear accidents, they are not adequate to protect victims and have not been widely ratified. The failure to require nuclear operators to prepare for damage that may result from accidents constitutes a subsidy to the nuclear industry and makes it difficult to compare the real costs of nuclear energy with the costs of other energy sources. This survey of settled norms and unresolved issues demonstrates that further work is needed to develop a comprehensive and authoritative regime to govern harm from nuclear activities. Although it is clear that both the operators of nuclear facilities and the states that have jurisdiction over them would be responsible to provide restitution and compensation for such harm under a strict liability regime, the types of injuries that must be compensated and the range of damages that must be covered remain subjects of controversy. Although the underlying customary international law principles (the no-harm principle and the polluter-pays principle) are clear, the actual treaties that have been drafted are inadequate and they have not been widely ratified. Victims of damage from nuclear activities would have difficulty finding a neutral tribunal in which to bring their claims and would face procedural obstacles including caps on liabilities and inappropriately short statutes of limitations as well as difficulties regarding proof of damages. The failure to develop a proper regime that would ensure full restitution and compensation for harm resulting from nuclear facilities

  5. The convention on supplementary compensation for nuclear damage (CSC). A cornerstone of a global nuclear liability regime?

    International Nuclear Information System (INIS)

    Pelzer, Norbert

    2015-01-01

    International discussions on compensation of nuclear damage seem to be governed by the magic word ''global nuclear liability regime''. It is said that only such regime promises to guarantee full and timely compensation at conditions acceptable and favourable for both the victims and the operator liable and at the same time promotes nuclear industry. Surely, nuclear incidents may have worldwide implications, and a globally unified legal framework appears to be desirable or is even necessitated. But until today we have not yet achieved a global regime. There are international nuclear liability conventions some of which may be qualified to form such regime. But which of them is best qualified and which one could be accepted by all States? Mainly the USA opt for, and strongly support, the 1997 ''Convention on Supplementary Compensation for Nuclear Damage'' (CSC) to be the only international instrument which is apt to form a global regime. This paper will deal with the question whether this assertion is convincing. It will also be asked whether we need a global regime.

  6. The convention on supplementary compensation for nuclear damage (CSC). A cornerstone of a global nuclear liability regime?

    Energy Technology Data Exchange (ETDEWEB)

    Pelzer, Norbert

    2015-06-15

    International discussions on compensation of nuclear damage seem to be governed by the magic word ''global nuclear liability regime''. It is said that only such regime promises to guarantee full and timely compensation at conditions acceptable and favourable for both the victims and the operator liable and at the same time promotes nuclear industry. Surely, nuclear incidents may have worldwide implications, and a globally unified legal framework appears to be desirable or is even necessitated. But until today we have not yet achieved a global regime. There are international nuclear liability conventions some of which may be qualified to form such regime. But which of them is best qualified and which one could be accepted by all States? Mainly the USA opt for, and strongly support, the 1997 ''Convention on Supplementary Compensation for Nuclear Damage'' (CSC) to be the only international instrument which is apt to form a global regime. This paper will deal with the question whether this assertion is convincing. It will also be asked whether we need a global regime.

  7. Nuclear data for analysis of radiation damage processes

    International Nuclear Information System (INIS)

    Aruga, Takeo

    1999-01-01

    Parameters needed to analyze radiation damages for neutron irradiations are presented, taking iron samples irradiated with JMTR neutrons for an example. Special interests have been put on a comparison between results obtained by irradiations for one case with a full neutron spectrum and the other with a Cd-shielded neutron spectrum. A possibility is described that although atomic displacement rates for the two case differ only less than 2%, production rates of freely migrating defects can differ appreciably, due to recoiled atoms by (n, γ) reactions. More over, it is also suggested that although the median energy of PKA, defined as a PKA energy above (or below) which one half of the total atomic displacements are to be produced, may differ only slightly between the two cases, final radiation effects can be significantly different. The effects of charged particles emitted with high energies due to nucleon irradiations are stressed in relation to the significance of defects produced by PKAs with lower energies than several keV, especially for the case of irradiations with highly energetic nucleons as anticipated in GeV proton irradiations. (author)

  8. Nuclear data for analysis of radiation damage processes

    Energy Technology Data Exchange (ETDEWEB)

    Aruga, Takeo [Department of Materials Science Research, Japan Atomic Energy Research Institute, Tokai, Ibaraki (Japan)

    1999-03-01

    Parameters needed to analyze radiation damages for neutron irradiations are presented, taking iron samples irradiated with JMTR neutrons for an example. Special interests have been put on a comparison between results obtained by irradiations for one case with a full neutron spectrum and the other with a Cd-shielded neutron spectrum. A possibility is described that although atomic displacement rates for the two case differ only less than 2%, production rates of freely migrating defects can differ appreciably, due to recoiled atoms by (n, {gamma}) reactions. More over, it is also suggested that although the median energy of PKA, defined as a PKA energy above (or below) which one half of the total atomic displacements are to be produced, may differ only slightly between the two cases, final radiation effects can be significantly different. The effects of charged particles emitted with high energies due to nucleon irradiations are stressed in relation to the significance of defects produced by PKAs with lower energies than several keV, especially for the case of irradiations with highly energetic nucleons as anticipated in GeV proton irradiations. (author)

  9. Aspects of the Brazilian law on civil liability for nuclear damage

    International Nuclear Information System (INIS)

    Rocha, L.M.G. da

    1980-06-01

    The civil liability for nuclear damage in the Brazilian law is analysed. The innovations introduced by the 6.453 act of October 17 th, 1977 are emphasized. The influence of international conventions on the Brazilian law are also mentioned. (A.L.) [pt

  10. Compensation for nuclear damage: a comparison among the international regime, Japan and China

    NARCIS (Netherlands)

    Liu, J.; Faure, Michael

    2016-01-01

    Following the Fukushima disaster in Japan in 2011, how the compensation system for nuclear damage should be improved has obtained broad attention. The compensation system, including liability rules, insurance and government involvement, does not only concern to what extent the victims can be

  11. Protocol to amend the Vienna convention on civil liability for nuclear damage

    International Nuclear Information System (INIS)

    1998-01-01

    The document reproduces the text of the Protocol to Amend the Vienna Convention on Civil Liability for Nuclear Damage which was adopted by a Diplomatic Conference, 8-12 September 1997, and the consolidated text of the 1963 Vienna Convention as amended by the Protocol

  12. Protocol to amend the Vienna convention on civil liability for nuclear damage

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-07-22

    The document reproduces the text of the Protocol to Amend the Vienna Convention on Civil Liability for Nuclear Damage which was adopted by a Diplomatic Conference, 8-12 September 1997, and the consolidated text of the 1963 Vienna Convention as amended by the Protocol

  13. Development of seismic damage assessment system for nuclear power plant structures in Korea

    International Nuclear Information System (INIS)

    Hyun, Chang-Hun; Lee, Sung-Kyu; Choi, Kang-Ryoung; Koh, Hyun-Moo; Cho, HoHyun

    2003-01-01

    A seismic damage assessment system that analyses in real-time the actual seismic resistance capacity and the damage level of power plant structures has been developed. The system consists of three parts: a 3-D inelastic seismic analysis, a damage assessment using a damage index based on the previous 3-D analysis, and a 3-D graphic representation. PSC containment structures are modelled by finite shell elements using layered method and analysis is performed by means of time history inelastic seismic analysis method, which takes into account material nonlinearities. HHT-α, one kind of direct integration method, is adopted for the seismic analysis. Two damage indices at finite element and structural levels are applied for the seismic damage assessment. 3-D graphical representation of dynamic responses and damage index expedites procedure for evaluating the damage level. The developed system is now being installed at the Earthquake Monitoring Center of KINS (Korea Institute of Nuclear Safety) to support site inspections after an earthquake occurrence, and decisions about effective emergency measures, repair and operations of the plant. (author)

  14. Legal analysis at the Law for Civil liabilities by nuclear damage; Analisis juridico a la Ley de responsabilidad civil por danos nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez G, A

    2000-07-01

    The present work has the objective to analyse in specific terms the legal regime of the Civil liability by nuclear damage. It has been the intention of that this compilation is the initiation of a large way which awake the interests of jurists and specialists dedicated to study the aspects as the liability by nuclear damage, compensation guarantee, risk and nuclear damage among others. The peaceful applications of the nuclear energy require the necessity of a legal ordinance that it is updated according to the nuclear technology development that the regulations of the common law do not cover. This work is initiated mentioning some antecedents of the nuclear energy law in Mexico. Also is realized the study of the elemental concepts and definitions about the subject as the evolution of the legal figure in the National law frame where the jurist must do an incursion in the nuclear field and make use of scientific and technical terminology. It was analysed and it was made the reflection of the legal figure of liability, its exoneration cases, about the concepts of risk and nuclear damage overcoming the conceptual error among them. It is talked about the study of nuclear damage and its repairing as financial guarantee to compensate to the people injured by a nuclear accident. Finally, it was treated about the legal analysis and proposals of additions and reforms for updating the Nuclear damage liability Law, concluding with general contributions to the Law resulting products of this work. (Author)

  15. Organizing irresponsibility? The (inter)national management of a nuclear accident damages as discursive regime

    International Nuclear Information System (INIS)

    Topcu, Sezin

    2014-01-01

    This article analyzes the historical process related to the international organization of responsibilities and the management of the damages in case of a nuclear disaster. The author shows that the political and legal settings on which the discourse of an 'international regime of civil responsibility' (that emerged in the 1960's) relies, have globally aimed at maintaining a 'historical and spectacular gap' between the damages the nuclear operators are taking responsibility for, and the real and extensive damages engendered by a major accident. She argues that the existence of such a 'gap' is inherent to the nuclear sector, that it is a form of government (both of economic affairs and of the public space) which was historically constructed, and that the existence of such a gap is crucial for the survival of the nuclear industry itself. Thus the notion of 'responsibility' in the nuclear sector appears to serve mainly as a discursive regime, as a means to organize not only responsibilities but also irresponsibilities, whatever the geographic scale (national or international) at which they should be managed

  16. Efficient prevention and compensation of catastrophic risks. The example of damage by nuclear accidents

    International Nuclear Information System (INIS)

    Vanden Borre, T.

    2001-01-01

    This book deals with the liability for damage due to catastrophic risks. The nuclear liability law serves as an example of such a catastrophic risk. The question that we tried to answer is what an efficient compensation scheme for catastrophic risks should look like. This question is dealt with both from a law and an economic point of view and from a comparative point of view. The main element in comparing the laws in different countries is the comparison between Belgian and Dutch civil (nuclear) liability law. But also American nuclear liability law is part of the analysis (the Price-Anderson Act). The book consists of four parts: (nuclear) civil liability law, legal and economic approach, analysis of other compensation systems and conclusions. The big themes in this book are therefore civil (nuclear) liability law, insurance law and environmental liability law [nl

  17. Mitochondrial and Nuclear DNA Damage and Repair in Age-Related Macular Degeneration

    Directory of Open Access Journals (Sweden)

    Janusz Blasiak

    2013-01-01

    Full Text Available Aging and oxidative stress seem to be the most important factors in the pathogenesis of age-related macular degeneration (AMD, a condition affecting many elderly people in the developed world. However, aging is associated with the accumulation of oxidative damage in many biomolecules, including DNA. Furthermore, mitochondria may be especially important in this process because the reactive oxygen species produced in their electron transport chain can damage cellular components. Therefore, the cellular response to DNA damage, expressed mainly through DNA repair, may play an important role in AMD etiology. In several studies the increase in mitochondrial DNA (mtDNA damage and mutations, and the decrease in the efficacy of DNA repair have been correlated with the occurrence and the stage of AMD. It has also been shown that mitochondrial DNA accumulates more DNA lesions than nuclear DNA in AMD. However, the DNA damage response in mitochondria is executed by nucleus-encoded proteins, and thus mutagenesis in nuclear DNA (nDNA may affect the ability to respond to mutagenesis in its mitochondrial counterpart. We reported that lymphocytes from AMD patients displayed a higher amount of total endogenous basal and oxidative DNA damage, exhibited a higher sensitivity to hydrogen peroxide and UV radiation, and repaired the lesions induced by these factors less effectively than did cells from control individuals. We postulate that poor efficacy of DNA repair (i.e., is impaired above average for a particular age when combined with the enhanced sensitivity of retinal pigment epithelium cells to environmental stress factors, contributes to the pathogenesis of AMD. Collectively, these data suggest that the cellular response to both mitochondrial and nuclear DNA damage may play an important role in AMD pathogenesis.

  18. The protection against nuclear risks under the international nuclear liability law: the geographical and technical scope of the international conventions on third party liability for nuclear damage

    International Nuclear Information System (INIS)

    Kissich, S.J.

    2001-10-01

    This Ph.D.-research deals with the International Conventions on Third Party Liability for Nuclear Damage. In 1960, the Paris Convention was established with the aim of providing a special uniform nuclear third party liability regime for Western Europe. This Convention was supplemented in 1963 by the Brussels Supplementary Convention. Also in 1963, the Vienna Convention, which aimed to establish a world-wide system based on the same principles as the Paris Convention, was adopted. A further Convention was adopted in 1971 to ensure that nuclear third party liability law and not maritime law would apply to carriage of nuclear materials by sea. In 1988, the Paris and Vienna Conventions have been linked by the adoption of a Joint Protocol. In 1997, the process of amending the 1963 Vienna Convention was successfully concluded and a Convention on Supplementary Compensation was adopted. This Ph.D.-research consists of seven chapters: following an introduction, the second chapter gives a general view of the existing international legal sources. The third chapter describes the international civil nuclear liability law concept and its leading principles. The main element of this work is the question of the technical and geographical scope of the international nuclear liability conventions (chapter IV and V). The conventions are only applicable to nuclear incidents, which occur in a nuclear installation or incidental to the carriage or storage of nuclear material. The nuclear damage must arise out of the radioactive properties of nuclear substances which are also defined by legal terms. In addition, the scope of the conventions is limited by the nature of the installations. The geographical scope of application is established by the provisions on geographical coverage. Only the 1963 Vienna Convention does not contain any specific provision dealing with the territorial scope of its application. The geographical scope determines where the nuclear incident or the nuclear damage

  19. Issues and decisions for nuclear power plant management after fuel damage events

    International Nuclear Information System (INIS)

    1997-04-01

    Experience has shown that the on-site activities following an incident that results in severely damaged fuel at a nuclear power plant required extraordinary effort. Even in cases that are not extreme but in which fuel damage is greater than mentioned in the specifications for operation, the recovery will require extensive work. This publication includes information from several projects at the IAEA since 1989 that have resulted in a Technical Report, a TECDOC and a Workshop. While the initial purpose of the projects was focused on providing technical information transfer to the experts engaged in recovery work at the damaged unit of Chernobyl NPP, the results have led to a general approach to managing events in which there is substantial fuel damage. This TECDOC summarizes the work to focus on management issues that may be encountered in any such event whether small or large. 11 refs, 2 figs, 5 tabs

  20. Nuclear magnetic resonance-based metabolomics for prediction of gastric damage induced by indomethacin in rats

    International Nuclear Information System (INIS)

    Um, So Young; Park, Jung Hyun; Chung, Myeon Woo; Kim, Kyu-Bong; Kim, Seon Hwa; Choi, Ki Hwan; Lee, Hwa Jeong

    2012-01-01

    Highlights: ► NMR based metabolomics – gastric damage by indomethacin. ► Pattern recognition analysis was performed to biomarkers of gastric damage. ► 2-Oxoglutarate, acetate, taurine and hippurate were selected as putative biomarkers. ► The gastric damage induced by NSAIDs can be screened in the preclinical step of drug. - Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) have side effects including gastric erosions, ulceration and bleeding. In this study, pattern recognition analysis of the 1 H-nuclear magnetic resonance (NMR) spectra of urine was performed to develop surrogate biomarkers related to the gastrointestinal (GI) damage induced by indomethacin in rats. Urine was collected for 5 h after oral administration of indomethacin (25 mg kg −1 ) or co-administration with cimetidine (100 mg kg −1 ), which protects against GI damage. The 1 H-NMR urine spectra were divided into spectral bins (0.04 ppm) for global profiling, and 36 endogenous metabolites were assigned for targeted profiling. The level of gastric damage in each animal was also determined. Indomethacin caused severe gastric damage; however, indomethacin administered with cimetidine did not. Simultaneously, the patterns of changes in their endogenous metabolites were different. Multivariate data analyses were carried out to recognize the spectral pattern of endogenous metabolites related to indomethacin using partial least square-discrimination analysis. In targeted profiling, a few endogenous metabolites, 2-oxoglutarate, acetate, taurine and hippurate, were selected as putative biomarkers for the gastric damage induced by indomethacin. These metabolites changed depending on the degree of GI damage, although the same dose of indomethacin (10 mg kg −1 ) was administered to rats. The results of global and targeted profiling suggest that the gastric damage induced by NSAIDs can be screened in the preclinical stage of drug development using a NMR based metabolomics approach.

  1. Nuclear magnetic resonance-based metabolomics for prediction of gastric damage induced by indomethacin in rats

    Energy Technology Data Exchange (ETDEWEB)

    Um, So Young [Department of Pharmacology, National Institute of Toxicological Research, Korea Food and Drug Administration, 643 Yeonje-ri, Gangoe-myeon, Cheongwon-gun, Chungbuk (Korea, Republic of); Division of Life and Pharmaceutical Science and College of Pharmacy, Ewha Womans University, 52 Ewahyeodae-gil, Seodaemun-gu, Seoul (Korea, Republic of); Park, Jung Hyun [Division of Life and Pharmaceutical Science and College of Pharmacy, Ewha Womans University, 52 Ewahyeodae-gil, Seodaemun-gu, Seoul (Korea, Republic of); Chung, Myeon Woo [Department of Pharmacology, National Institute of Toxicological Research, Korea Food and Drug Administration, 643 Yeonje-ri, Gangoe-myeon, Cheongwon-gun, Chungbuk (Korea, Republic of); Kim, Kyu-Bong [College of Pharmacy, Dankook University, Dandae-ro, Cheonan, Chungnam (Korea, Republic of); Kim, Seon Hwa [Department of Pharmacology, National Institute of Toxicological Research, Korea Food and Drug Administration, 643 Yeonje-ri, Gangoe-myeon, Cheongwon-gun, Chungbuk (Korea, Republic of); Division of Life and Pharmaceutical Science and College of Pharmacy, Ewha Womans University, 52 Ewahyeodae-gil, Seodaemun-gu, Seoul (Korea, Republic of); College of Pharmacy, Dankook University, Dandae-ro, Cheonan, Chungnam (Korea, Republic of); Choi, Ki Hwan, E-mail: hyokwa11@korea.kr [Department of Pharmacology, National Institute of Toxicological Research, Korea Food and Drug Administration, 643 Yeonje-ri, Gangoe-myeon, Cheongwon-gun, Chungbuk (Korea, Republic of); Lee, Hwa Jeong, E-mail: hwalee@ewha.ac.kr [Division of Life and Pharmaceutical Science and College of Pharmacy, Ewha Womans University, 52 Ewahyeodae-gil, Seodaemun-gu, Seoul (Korea, Republic of)

    2012-04-13

    Highlights: Black-Right-Pointing-Pointer NMR based metabolomics - gastric damage by indomethacin. Black-Right-Pointing-Pointer Pattern recognition analysis was performed to biomarkers of gastric damage. Black-Right-Pointing-Pointer 2-Oxoglutarate, acetate, taurine and hippurate were selected as putative biomarkers. Black-Right-Pointing-Pointer The gastric damage induced by NSAIDs can be screened in the preclinical step of drug. - Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) have side effects including gastric erosions, ulceration and bleeding. In this study, pattern recognition analysis of the {sup 1}H-nuclear magnetic resonance (NMR) spectra of urine was performed to develop surrogate biomarkers related to the gastrointestinal (GI) damage induced by indomethacin in rats. Urine was collected for 5 h after oral administration of indomethacin (25 mg kg{sup -1}) or co-administration with cimetidine (100 mg kg{sup -1}), which protects against GI damage. The {sup 1}H-NMR urine spectra were divided into spectral bins (0.04 ppm) for global profiling, and 36 endogenous metabolites were assigned for targeted profiling. The level of gastric damage in each animal was also determined. Indomethacin caused severe gastric damage; however, indomethacin administered with cimetidine did not. Simultaneously, the patterns of changes in their endogenous metabolites were different. Multivariate data analyses were carried out to recognize the spectral pattern of endogenous metabolites related to indomethacin using partial least square-discrimination analysis. In targeted profiling, a few endogenous metabolites, 2-oxoglutarate, acetate, taurine and hippurate, were selected as putative biomarkers for the gastric damage induced by indomethacin. These metabolites changed depending on the degree of GI damage, although the same dose of indomethacin (10 mg kg{sup -1}) was administered to rats. The results of global and targeted profiling suggest that the gastric damage induced by

  2. Main features of the convention on supplementary compensation for nuclear damage - an over view

    International Nuclear Information System (INIS)

    Boulanenkov, V.

    2000-01-01

    The Chernobyl accident prompted widespread awareness of the need for improved protection of the public from the consequences of nuclear accidents. It was generally recognised that urgent efforts should be undertaken to strengthen the international nuclear liability regime based on two civil law conventions, namely the 1963 Vienna Convention on Civil Liability for Nuclear Damage and the 1960 Paris Convention on Third Party Liability in the Field of Nuclear Energy. The work initiated by the Agency - it was assigned to the Standing Committee established in 1990 - followed a two-track approach: to improve the existing civil liability regime, including revision of the Vienna Convention for which the IAEA is depositary; and, to develop a comprehensive international liability regime. The issue of compensation additional to that available under the two basic conventions received full attention in the negotiations. In the latter context, this work resulted in the adoption by a diplomatic conference convened by the IAEA in September 1997 of a new instrument, i.e. the Convention on Supplementary Compensation for Nuclear Damage (the CSC). The CSC is a product of many years of multilateral negotiations and represents a balance of various legal, economic and political considerations. While not all concerns may have been fully met, it represents a significant improvement in the protection of the public from the consequences of nuclear accidents. (author)

  3. Liability for nuclear damage: an international perspective. Reflections on the revision of the Vienna Convention

    Energy Technology Data Exchange (ETDEWEB)

    Lopuski, J

    1994-12-31

    This book deals with deals of the complex issues of liability and compensation for nuclear damage which have been considered in the course of the work of the IAEA concerning the revision of the Vienna Convention on nuclear liability. It presents, in an orderly way, personal reflections of its author based on his experience gathered in years 1989-1992 when participating in this work. Necessarily it contains in some of its parts references to documents of the IAEA Standing Committee on Nuclear Liability; these documents because of their length could not be reproduced. Consequently these parts may not be fully intelligible for those who have not participated in or closely followed the Committee`s work. The IAEA work on liability for nuclear damage was initiated in the wake of the impact made on the world`s public opinion by the Chernobyl incident and its transboundary effects; issues of international state liability and full compensation have been raised. But humanitarian ideas have quickly been confronted with cold calculations of the cost of financial protection for victims and an open unwillingness of some nuclear states has been manifested. After three years of discussions no wide consensus could be reached on some basic issues, such as: relationship between international state and civil liability regimes, structure of international legislation, concept of nuclear damage, limits of compensation, role of public funds or jurisdiction. The author presents his approach to these controversial issue, trying to provide at the same time a theoretical outline for the future international legislation on nuclear liability. (author).

  4. Liability for nuclear damage: an international perspective. Reflections on the revision of the Vienna Convention

    Energy Technology Data Exchange (ETDEWEB)

    Lopuski, J.

    1993-12-31

    This book deals with deals of the complex issues of liability and compensation for nuclear damage which have been considered in the course of the work of the IAEA concerning the revision of the Vienna Convention on nuclear liability. It presents, in an orderly way, personal reflections of its author based on his experience gathered in years 1989-1992 when participating in this work. Necessarily it contains in some of its parts references to documents of the IAEA Standing Committee on Nuclear Liability; these documents because of their length could not be reproduced. Consequently these parts may not be fully intelligible for those who have not participated in or closely followed the Committee`s work. The IAEA work on liability for nuclear damage was initiated in the wake of the impact made on the world`s public opinion by the Chernobyl incident and its transboundary effects; issues of international state liability and full compensation have been raised. But humanitarian ideas have quickly been confronted with cold calculations of the cost of financial protection for victims and an open unwillingness of some nuclear states has been manifested. After three years of discussions no wide consensus could be reached on some basic issues, such as: relationship between international state and civil liability regimes, structure of international legislation, concept of nuclear damage, limits of compensation, role of public funds or jurisdiction. The author presents his approach to these controversial issue, trying to provide at the same time a theoretical outline for the future international legislation on nuclear liability. (author).

  5. Development of a seismic damage assessment program for nuclear power plant structures

    Energy Technology Data Exchange (ETDEWEB)

    Koh, Hyun Moo; Cho, Yang Heui; Shin, Hyun Mok [Seoul National Univ., Seoul (Korea, Republic of)] (and others)

    2001-12-15

    The most part of the nuclear power plants operating currently in Korea are more than 20 years old and obviously we cannot pretend that their original performance is actually maintained. In addition, earthquake occurrences show an increasing trend all over the world, and Korea can no more be considered as a zone safe from earthquake. Therefore, need is to guarantee the safety of these power plant structures against seismic accident, to decide to maintain them operational and to obtain data relative to maintenance/repair. Such objectives can be reached by damage assessment using inelastic seismic analysis considering aging degradation. It appears to be more important particularly for the structure enclosing the nuclear reactor that must absolutely protect against any radioactive leakage. Actually, the tendency of the technical world, led by the OECD/NEA, BNL in the United States, CEA in France and IAEA, is to develop researches or programs to assess the seismic safety considering aging degradation of operating nuclear power plants. Regard to the above-mentioned international technical trend, a technology to establish inelastic seismic analysis considering aging degradation so as to assess damage level and seismic safety margin appears to be necessary. Damage assessment and prediction system to grasp in real-time the actual seismic resistance capacity and damage level by 3-dimensional graphic representations are also required.

  6. Development of a seismic damage assessment program for nuclear power plant structures

    Energy Technology Data Exchange (ETDEWEB)

    Koh, Hyun Moo; Cho, Ho Hyun; Cho, Yang Hui [Seoul National Univ., Seoul (Korea, Republic of)] (and others)

    2000-12-15

    Some of nuclear power plants operating currently in Korea have been passed about 20 years after construction. Moreover, in the case of KORI I the service year is over 20 years, so their abilities are different from initial abilities. Also, earthquake outbreak increase, our country is not safe area for earthquake. Therefore, need is to guarantee the safety of these power plant structures against seismic accident, to decide to maintain them operational and to obtain data relative to maintenance/repair. Such objectives can be reached by damage assessment using inelastic seismic analysis considering aging degradation. It appears to be more important particularly for the structure enclosing the nuclear reactor that must absolutely protect against any radioactive leakage. Actually, the tendency of the technical world, led by the OECD/NEA, BNL in the United States, CEA in France and IAEA, is to develop researches or programs to assess the seismic safety considering aging degradation of operating nuclear power plants. Regard to the above-mentioned international technical trend, a technology to establish inelastic seismic analysis considering aging degradation so as to assess damage level and seismic safety margin appears to be necessary. Damage assessment and prediction system to grasp in real-time the actual seismic resistance capacity and damage level by 3-dimensional graphic representations are also required.

  7. The order for enforcing the law on indemnity agreement for compensation of nuclear damage

    International Nuclear Information System (INIS)

    1980-01-01

    The cabinet ordinance is established under the provisions of the law concerning atomic energy damage indemnification contract. The damage indemnifications in this law cover the occasions when there is not the cause for atomic energy damages due to the violation of the specified provisions of the law concerning the regulation of nuclear raw materials, nuclear fuel materials and reactors, the failures of operation facilities for reactors and natural calamity or the deed of a third party. The rate of indemnification fees is stipulated at 5/10,000. An enterpriser of atomic energy business shall inform the following matters to the government concerning the indemnification contracts. The objects of operation of reactors; the types, thermal output and number of reactors; the names and addresses of works or places of business where reactors are set up; the locations, structures and equipments of reactor facilities; beginning dates and expected ending dates of the operation on reactors; the kinds and estimated quantities of use in a year of nuclear fuel materials employed for reactors; the methods of disposal of spent fuels and the matters concerning liability insurance contracts. The matters to be reported to the government are specified respectively for the indemnification contracts for the processing, reprocessing, use, transport and disposal of nuclear fuel materials. The payment of indemnification fees and indemnities, the cancellation of indemnification contracts and the fines for default are particularly defined. (Okada, K.)

  8. Changes in nuclear protein acetylation in u.v.-damaged human cells

    International Nuclear Information System (INIS)

    Ramanathan, B.; Smerdon, M.J.

    1986-01-01

    The levels of nuclear protein acetylation in u.v.-irradiated human fibroblasts have been investigated. Initially, we measured the levels of acetylation in total acid-soluble nuclear proteins and observed two distinct differences between the irradiated and unirradiated (control) cells. Immediately after irradiation, there is a 'wave' of protein hyperacetylation that lasts for 2-6 h, followed by a hypoacetylation phase, lasting for many hours, and the total level of acetylation does not return to that of control cells until 24-72 h after u.v. damage. Both the magnitude and duration of each phase is dependent on the dose of u.v. light used. The wave of hyperacetylation is more pronounced at low u.v. doses, while the wave of hypoacetylation is more pronounced at higher u.v. doses. Furthermore, the duration of each phase is prolonged when cells are exposed to 2 mM hydroxyurea, an agent which retards the rate of excision repair at u.v.-damaged sites. Examinations of the acetylation levels of the individual nuclear proteins indicated that acetylation of the core histones follows the same pattern observed for the total acid-soluble protein fractions. Furthermore, these were the only major proteins in the total acid-soluble fraction observed to undergo the early, rapid hyperacetylation immediately following u.v. damage. These results raise the possibility that a causal relationship exists between nuclear protein acetylation and nucleotide excision repair of DNA in human cells. (author)

  9. Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage

    Directory of Open Access Journals (Sweden)

    Rolletschek Alexandra

    2009-06-01

    Full Text Available Abstract Background P53 is a key tumor suppressor protein. In response to DNA damage, p53 accumulates to high levels in differentiated cells and activates target genes that initiate cell cycle arrest and apoptosis. Since stem cells provide the proliferative cell pool within organisms, an efficient DNA damage response is crucial. Results In proliferating embryonic stem cells, p53 is localized predominantly in the cytoplasm. DNA damage-induced nuclear accumulation of p53 in embryonic stem cells activates transcription of the target genes mdm2, p21, puma and noxa. We observed bi-phasic kinetics for nuclear accumulation of p53 after ionizing radiation. During the first wave of nuclear accumulation, p53 levels were increased and the p53 target genes mdm2, p21 and puma were transcribed. Transcription of noxa correlated with the second wave of nuclear accumulation. Transcriptional activation of p53 target genes resulted in an increased amount of proteins with the exception of p21. While p21 transcripts were efficiently translated in 3T3 cells, we failed to see an increase in p21 protein levels after IR in embryonal stem cells. Conclusion In embryonic stem cells where (anti-proliferative p53 activity is not necessary, or even unfavorable, p53 is retained in the cytoplasm and prevented from activating its target genes. However, if its activity is beneficial or required, p53 is allowed to accumulate in the nucleus and activates its target genes, even in embryonic stem cells.

  10. Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage.

    Science.gov (United States)

    Solozobova, Valeriya; Rolletschek, Alexandra; Blattner, Christine

    2009-06-17

    P53 is a key tumor suppressor protein. In response to DNA damage, p53 accumulates to high levels in differentiated cells and activates target genes that initiate cell cycle arrest and apoptosis. Since stem cells provide the proliferative cell pool within organisms, an efficient DNA damage response is crucial. In proliferating embryonic stem cells, p53 is localized predominantly in the cytoplasm. DNA damage-induced nuclear accumulation of p53 in embryonic stem cells activates transcription of the target genes mdm2, p21, puma and noxa. We observed bi-phasic kinetics for nuclear accumulation of p53 after ionizing radiation. During the first wave of nuclear accumulation, p53 levels were increased and the p53 target genes mdm2, p21 and puma were transcribed. Transcription of noxa correlated with the second wave of nuclear accumulation. Transcriptional activation of p53 target genes resulted in an increased amount of proteins with the exception of p21. While p21 transcripts were efficiently translated in 3T3 cells, we failed to see an increase in p21 protein levels after IR in embryonal stem cells. In embryonic stem cells where (anti-proliferative) p53 activity is not necessary, or even unfavorable, p53 is retained in the cytoplasm and prevented from activating its target genes. However, if its activity is beneficial or required, p53 is allowed to accumulate in the nucleus and activates its target genes, even in embryonic stem cells.

  11. Japan's compensation system for nuclear damage - As related to the TEPCO Fukushima Daiichi nuclear accidents

    International Nuclear Information System (INIS)

    Nomura, Toyohiro; Matsuura, Shigekazu; Takahashi, Yasufumi; Takenaka, Chihiro; Hokugo, Taro; Kamada, Toshihiko; Kamai, Hiroyuki

    2012-01-01

    Following the TEPCO Fukushima Daiichi nuclear power plant accident, extraordinary efforts were undertaken in Japan to implement a compensation scheme for the proper and efficient indemnification of the affected victims. This publication provides English translations of key Japanese legislative and administrative texts and other implementing guidance, as well as several commentaries by Japanese experts in the field of third party nuclear liability. The OECD Nuclear Energy Agency (NEA) has prepared this publication in co-operation with the government of Japan to share Japan's recent experience in implementing its nuclear liability and compensation regime. The material presented in the publication should provide valuable insights for those wishing to better understand the regime applied to compensate the victims of the accident and for those working on potential improvements in national regimes and the international framework for third party nuclear liability

  12. Nuclear Liability and Insurance of Nuclear Damage in the Czech republic

    International Nuclear Information System (INIS)

    Zaruba, P.

    1998-01-01

    The paper gives a short introduction to the past and present situation of operation and construction of nuclear power plants in the Czech Republic, including some basic technical data and background information. It then continues in providing up to date information on the Czech nuclear legislation and consideration of various questions and problems in the light of the respective legal clauses (e.g. minimum insurance requirements, treatment of small reactors and small quantities of nuclear material, state guarantees etc.). The paper gives more detailed information about practical application of the insurance clauses of the Atomic Act, including some time related questions. A considerable part of the paper is dedicated to the past history and present functions and activities of the Czech Nuclear Insurance Pool which was officially founded in 1995 and is without doubt one of the most active and successful national nuclear insurance pools of the former East European countries. (author)

  13. Psychological health damage as an environmental effect: Metropolitan Edison Co. v. People Against Nuclear Energy

    International Nuclear Information System (INIS)

    Hoff, E.H.

    1984-01-01

    The Supreme court took a narrow view of the term environmental in Metropolitan Edison Co. v. People Against Nuclear Energy when it stated that the purpose of the National Environmental Policy Act (NEPA) is to protect the physical environment. Psychological health damage caused by the perception of the risk of a nuclear accident is not an environmental effect cognizable under NEPA unless their is a demonstrable relationship. Litigants seeking the protection of NEPA must carefully examine the origin and nature of alleged psychological harms and frame their complains to establish a close relationship between a change in the physical environment and the alleged psychological harm

  14. Liability according to civil law regarding border-crossing nuclear damage

    International Nuclear Information System (INIS)

    Baer, Caroline

    1987-12-01

    The problem of the liability in border-crossing damage caused by a nuclear-reactor accident is divided into two different areas: the liability according to international law of the state, and liability according to civil right of the licensee of a nuclear power plant. In this study attention is paid to the question of the liability according to civil right: is it possible that an aggrieved obtains compensation for damage? This is investigated on the basis of three standard questions of international private law: which judge is qualified, which law is to be applied, and is acknowledgement and execution of foreign sentences possible? First a historical survey is given of international agreements and national legislations regarding third-party liability. (author). 112 refs

  15. Changes in nuclear protein acetylation in u. v. -damaged human cells

    Energy Technology Data Exchange (ETDEWEB)

    Ramanathan, B.; Smerdon, M.J.

    1986-07-01

    We have investigated the levels of nuclear protein acetylation in u.v.-irradiated human fibroblasts. We measured the levels of acetylation in total acid-soluble nuclear proteins and observed two distinct differences between the irradiated and unirradiated (control) cells. Immediately after irradiation, there is a wave of protein hyperacetylation (i.e. a total acetylation level greater than that of unirradiated cells) that lasts for 2-6 h depending on the experimental conditions. This hyperacetylation phase is then followed by a hypoacetylation phase, lasting for many hours, and the total level of acetylation does not return to that of control cells until 24-72 h after u.v. damage. Both the magnitude and duration of each phase is dependent on the dose of u.v. light used. The wave of hyperacetylation is more pronounced at low u.v. doses (i.e. less than 5 J/m2), while the wave of hypoacetylation is more pronounced at higher u.v. doses (greater than or equal to 8 J/m2). Furthermore, the duration of each phase is prolonged when cells are exposed to 2 mM hydroxyurea. Examination of the acetylation levels of the individual nuclear proteins indicated that acetylation of the core histones follows the same pattern observed for the total acid-soluble protein fractions. Furthermore, these were the only major proteins in the total acid-soluble fraction observed to undergo the early, rapid hyperacetylation immediately following u.v. damage. Acetylation of histone H1 was negligible in both damaged and control cells, while three prominent non-histone proteins were acetylated only after long labeling times (greater than 4 h) in each case, gradually becoming hyperacetylated in the u.v.-damaged cells. These results raise the possibility that a causal relationship exists between nuclear protein acetylation and nucleotide excision repair of DNA in human cells.

  16. Effect of radiation damage on operating safety of steel pressure vessels of nuclear reactors

    International Nuclear Information System (INIS)

    Vacek, M.; Havel, S.; Stoces, B.; Brumovsky, M.

    1980-01-01

    The effects are assessed of the environment upon mechanical properties of steel used generally for pressure vessels of light water nuclear reactors. Changes caused by radiation affect the reliability of vessels. Deterioration of steel properties is mainly due to neutron radiation. The article deals with factors bearing upon damage and with methods allowing to evaluate the reliability of vessels and predict their service life. Operating reliability of vessels is very unfavourably affected by planned and accidental reactor transients. (author)

  17. Specific defences to the liability of a nuclear operator for damages resulting from a nuclear incident

    International Nuclear Information System (INIS)

    Schwartz, J.A.; Cunningham, G.H.

    1988-01-01

    This paper reviews the cases in which the nuclear operator may be partly or totally exonerated from his liability for a nuclear accident (insurrection, civil war, exceptional natural disasters, intentional act of the victim, etc.) under the Paris and Vienna Conventions and national laws. The laws of the countries reviewed are the following: United States, Japan, Canada, United Kingdom, Brazil, Belgium, the Federal Republic of Germany, France (NEA) [fr

  18. An overview of the international regime governing liability for nuclear damage

    International Nuclear Information System (INIS)

    Sturms, W.; Reye, S.

    1995-01-01

    Since 1986, the IAEA has been seized with considerations of all aspects of international nuclear liability, with a view to establishing a comprehensive international regime that would obtain widest adherence. The practical work is currently being done in the IAEA Standing Committee on Liability for Nuclear Damage. The efforts, which were first concentrated on the improvement of the existing civil liability regime, resulted in adoption, in 1988, of the Joint Protocol to the Vienna Convention and the Paris Convention, combining them into one expanded regime. At present, the work is focused on the following questions: (a) Revision of the Vienna Convention: In this context, specific draft amendments are considered relating to some key issues where need for improvement has been recognized, such as geographical scope, application to military installations, expansion of the definition of damage to cover environmental damage, preventative measures and consequential losses, increase of liability limits, provision of funds by the Installation State, extension of time limits for submission of claims, restriction of exonerations, etc. (b) International State liability and its relationship with the civil liability regime: Emphasis is placed on proposals for Installation State involvement in the provision of public funds in addition to compensation paid by the operator. (c) Elaboration of a supplementary funding system to cover damage exceeding compensation available under the Vienna and Paris Conventions

  19. Evaluation of cytogenetic damage in nuclear medicine personnel occupationally exposed to low-level ionising radiation

    International Nuclear Information System (INIS)

    Garaj-Vrhovac, V.; Kopjar, N.; Poropat, M.

    2005-01-01

    Despite intensive research over the last few decades, there still remains considerable uncertainty as to the genetic impact of ionising radiation on human populations, particularly at low levels. The aim of this study was to provide data on genetic hazards associated with occupational exposure to low doses of ionising radiation in nuclear medicine departments. The assessment of DNA damage in peripheral blood lymphocytes of medical staff was performed using the chromosome aberration (CA) test. Exposed subjects showed significantly higher frequencies of CA than controls. There were significant inter-individual differences in DNA damage within the exposed population, indicating differences in genome sensitivity. Age and gender were not confounding factors, while smoking enhanced the levels of DNA damage only in control subjects. The present study suggests that chronic exposure to low doses of ionising radiation in nuclear medicine departments causes genotoxic damage. Therefore, to avoid potential genotoxic effects, the exposed medical personnel should minimise radiation exposure wherever possible. Our results also point to the significance of biological indicators providing information about the actual risk to the radiation exposed individuals.(author)

  20. Summary Report of the Technical Meeting on Primary Radiation Damage: From Nuclear Reaction to Point Defects

    International Nuclear Information System (INIS)

    Stoller, R. E.; Nordlund, K.; Simakov, S.P.

    2012-11-01

    The Meeting was convened to bring together the experts from both the nuclear data and materials research communities because of their common objective of accurately characterizing irradiation environments and resulting material damage. The meeting demonstrated that significant uncertainties remain regarding both the status of nuclear data and the use of these data by the materials modeling community to determine the primary damage state obtained in irradiated materials. At the conclusion of the meeting, the participants agreed that there is clear motivation to initiate a CRP that engages participants from the nuclear data and materials research communities. The overall objective of this CRP would be to determine the best possible parameter (or a few parameters) for correlating damage from irradiation facilities with very different particle types and energy spectra, including fission and fusion reactors, charged particle accelerators, and spallation irradiation facilities. Regarding progress achieved during the last decade in the atomistic simulation of primary defects in crystalline materials, one of the essential and quantitative outcomes from the CRP is expected to be cross sections for point defects left after recoil cascade quenching. (author)

  1. Transportation of failed or damaged foreign research reactor spent nuclear fuel

    International Nuclear Information System (INIS)

    Messick, C.E.; Mustin, T.P.; Massey, C.D.

    1998-01-01

    Since resuming the Foreign Research Reactor Spent Nuclear Fuel (FRR SNF) Acceptance Program in 1996, the Program has had to deal with difficult issues associated with the transportation of failed or damaged spent fuel. In several instances, problems with failed or damaged fuel have prevented the acceptance of the fuel at considerable cost to both the Department of Energy (DOE) and research reactor operators. In response to the problems faced by the Acceptance Program, DOE has undertaken significant steps to better define the spent fuel acceptance criteria. DOE has worked closely with the U.S. Nuclear Regulatory Commission to address failed or damaged research reactor spent fuel and to identify cask certificate issues which must be resolved by cask owners and foreign regulatory authorities. The specific issues associated with the transport of Materials Testing Reactor (MTR)-type FRR SNF will be discussed. The information presented will include U.S. Nuclear Regulatory Commission regulatory issues, cask certificate issues, technical constraints, and lessons learned. Specific information will also be provided on the latest efforts to revise DOE's Appendix B, Transport Package (Cask) Acceptance Criteria. The information presented in this paper will be important to foreign research reactor operators, shippers, and cask vendors, so that appropriate amendments to the Certificate of Compliance for spent fuel casks can be submitted in a timely manner to facilitate the safe and scheduled transport of FRR SNF

  2. Transportation of failed or damaged foreign research reactor spent nuclear fuel

    International Nuclear Information System (INIS)

    Messick, Charles E.; Mustin, Tracy P.; Massey, Charles D.

    1999-01-01

    Since initiating the Foreign Research Reactor Spent Nuclear Fuel (FRR SNF) Acceptance Program in 1996, the Program has had to deal with difficult issues associated with the transportation of failed or damaged spent fuel. In several instances, problems with failed or damaged fuel have prevented the acceptance of the fuel at considerable cost to both the Department of Energy and research reactor operators. In response to the problems faced by the Acceptance Program, DOE has undertaken significant steps to better define the spent fuel acceptance criteria. DOE has worked closely with the U.S. Nuclear Regulatory Commission to address failed or damaged research reactor spent fuel causing a degradation of the fuel assembly exposing fuel meat and to identify cask certificate issues which must be resolved by cask owners and foreign regulatory authorities. The specific issues and implementation challenges associated with the transport of MTR type FRR SNF will be discussed. The information presented will include U.S. Nuclear Regulatory Commission regulatory issues, cask certificate issues, technical constraints, implementation status, and lessons learned. Specific information will also be provided on the latest efforts to revise DOE's Appendix B, Transport Package (Cask) Acceptance Criteria. The information presented in this paper will be of interest to foreign research reactor operators, shippers, and cask vendors in evaluating the condition of their fuel to ensure it can be transported in accordance with appropriate cask certificate requirements. (author)

  3. The OECD/NEA workshop on the indemnification of nuclear damage in the event of a nuclear accident

    International Nuclear Information System (INIS)

    Wagstaff, F.

    2002-01-01

    Since 1993, the OECD Nuclear Energy Agency (OECD/NEA) has run the International Nuclear Emergency Exercise (INEX) Program. The program serves to discuss an effective accident management approach on the basis of a simulated nuclear accident situation together with the states involved and their institutions, and also elaborate measures for its further improvement. At the present time, the INEX Program has reached Phase 3 in which, for the first time, also aspects of liability for the consequences of accidents were included. These aspects were made the subject of a workshop held after an emergency exercise. The scenario covered was based on an INES level-4 accident in the French Gravelines Nuclear Power Station situated close to the French-Belgian border. The workshop dealt with these topics, among others: the application of the Paris Convention on Third Party Liability, the Brussels Supplementary Convention, and the Vienna Convention on Civil Liability for Nuclear Damage as well as the Supplementary Compensation Convention of 1997. It was seen that there was a clear need for further discussion, especially to shed more light on the interrelationship of these treaties. (orig.) [de

  4. Vienna Convention and Its Revision and convention on Supplementary Compensation for Nuclear Damage on September 12, 1997

    International Nuclear Information System (INIS)

    Soljan, V.

    1998-01-01

    After Chernobyl, the perception of common interest in modernization of the international regime that regulate various aspects of nuclear energy, has been evident among states with nuclear power plants as well as those likely to be involved in or affected by a nuclear incident. The adoption of the protocol Amending the Vienna Convention on Civil liability for Nuclear Damage, 1963 and the Convention on Supplementary Compensation for nuclear damage in September 1997, represents important part of the entire result that has been achieved from the 1986. This article gives a brief survey on the background of the process of modernization of the international regime of liability for nuclear damage and examines solutions contained in the provisions of the conventions. (author)

  5. Quantitative PCR analysis of diepoxybutane and epihalohydrin damage to nuclear versus mitochondrial DNA

    Energy Technology Data Exchange (ETDEWEB)

    LaRiviere, Frederick J. [Department of Chemistry, Washington and Lee University, Lexington, VA 24450 (United States); Newman, Adam G.; Watts, Megan L.; Bradley, Sharonda Q.; Juskewitch, Justin E. [Department of Chemistry, Colby College, 5757 Mayflower Hill Drive, Waterville, ME 04901 (United States); Greenwood, Paul G. [Department of Biology, Colby College, Waterville, ME 04901 (United States); Millard, Julie T., E-mail: jtmillar@colby.edu [Department of Chemistry, Colby College, 5757 Mayflower Hill Drive, Waterville, ME 04901 (United States)

    2009-05-12

    The bifunctional alkylating agents diepoxybutane (DEB) and epichlorohydrin (ECH) are linked to the elevated incidence of certain cancers among workers in the synthetic polymer industry. Both compounds form interstrand cross-links within duplex DNA, an activity suggested to contribute to their cytotoxicity. To assess the DNA targeting of these compounds in vivo, we assayed for damage within chicken erythro-progenitor cells at three different sites: one within mitochondrial DNA, one within expressed nuclear DNA, and one within unexpressed nuclear DNA. We determined the degree of damage at each site via a quantitative polymerase chain reaction, which compares amplification of control, untreated DNA to that from cells exposed to the agent in question. We found that ECH and the related compound epibromohydrin preferentially target nuclear DNA relative to mitochondrial DNA, whereas DEB reacts similarly with the two genomes. Decreased reactivity of the mitochondrial genome could contribute to the reduced apoptotic potential of ECH relative to DEB. Additionally, formation of lesions by all agents occurred at comparable levels for unexpressed and expressed nuclear loci, suggesting that alkylation is unaffected by the degree of chromatin condensation.

  6. Quantitative PCR analysis of diepoxybutane and epihalohydrin damage to nuclear versus mitochondrial DNA

    International Nuclear Information System (INIS)

    LaRiviere, Frederick J.; Newman, Adam G.; Watts, Megan L.; Bradley, Sharonda Q.; Juskewitch, Justin E.; Greenwood, Paul G.; Millard, Julie T.

    2009-01-01

    The bifunctional alkylating agents diepoxybutane (DEB) and epichlorohydrin (ECH) are linked to the elevated incidence of certain cancers among workers in the synthetic polymer industry. Both compounds form interstrand cross-links within duplex DNA, an activity suggested to contribute to their cytotoxicity. To assess the DNA targeting of these compounds in vivo, we assayed for damage within chicken erythro-progenitor cells at three different sites: one within mitochondrial DNA, one within expressed nuclear DNA, and one within unexpressed nuclear DNA. We determined the degree of damage at each site via a quantitative polymerase chain reaction, which compares amplification of control, untreated DNA to that from cells exposed to the agent in question. We found that ECH and the related compound epibromohydrin preferentially target nuclear DNA relative to mitochondrial DNA, whereas DEB reacts similarly with the two genomes. Decreased reactivity of the mitochondrial genome could contribute to the reduced apoptotic potential of ECH relative to DEB. Additionally, formation of lesions by all agents occurred at comparable levels for unexpressed and expressed nuclear loci, suggesting that alkylation is unaffected by the degree of chromatin condensation.

  7. Nuclear Containment Inspection Using AN Array of Guided Wave Sensors for Damage Localization

    Science.gov (United States)

    Cobb, A. C.; Fisher, J. L.

    2010-02-01

    Nuclear power plant containments are typically both the last line of defense against the release of radioactivity to the environment and the first line of defense to protect against intrusion from external objects. As such, it is important to be able to locate any damage that would limit the integrity of the containment itself. Typically, a portion of the containment consists of a metallic pressure boundary that encloses the reactor primary circuit. It is made of thick steel plates welded together, lined with concrete and partially buried, limiting areas that can be visually inspected for corrosion damage. This study presents a strategy using low frequency (<50 kHz) guided waves to find corrosion-like damage several meters from the probe in a mock-up of the containment vessel. A magnetostrictive sensor (MsS) is scanned across the width of the vessel, acquiring waveforms at a fixed interval. A beam forming strategy is used to localize the defects. Experimental results are presented for a variety of damage configurations, demonstrating the efficacy of this technique for detecting damage smaller than the ultrasonic wavelength.

  8. Novel Concepts for Damage-Resistant Alloys in Next Generation Nuclear Power Systems

    Energy Technology Data Exchange (ETDEWEB)

    Stephen M. Bruemmer; Peter L. Andersen; Gary Was

    2002-12-27

    The discovery of a damage-resistant alloy based on Hf solute additions to a low-carbon 316SS is the highlight of the Phase II research. This damage resistance is supported by characterization of radiation-induced microstructures and microchemistries along with measurements of environmental cracking. The addition of Hf to a low-carbon 316SS reduced the detrimental impact of radiation by changing the distribution of Hf. Pt additions reduced the impact of radiation on grain boundary segregation but did not alter its effect on microstructural damage development or cracking. Because cracking susceptibility is associated with several material characteristics, separate effect experiments exploring strength effects using non-irradiated stainless steels were conducted. These crack growth tests suggest that irradiation strength by itself can promote environmental cracking. The second concept for developing damage resistant alloys is the use of metastable precipitates to stabilize the microstructure during irradiation. Three alloys have been tailored for evaluation of precipitate stability influences on damage evolution. The first alloy is a Ni-base alloy (alloy 718) that has been characterized at low neutron irradiation doses but has not been characterized at high irradiation doses. The other two alloys are Fe-base alloys (PH 17-7 and PH 17-4) that have similar precipitate structures as alloy 718 but is more practical in nuclear structures because of the lower Ni content and hence lesser transmutation to He.

  9. Damaged Spent Nuclear Fuel at U.S. DOE Facilities Experience and Lessons Learned

    International Nuclear Information System (INIS)

    Brett W. Carlsen; Eric Woolstenhulme; Roger McCormack

    2005-01-01

    From a handling perspective, any spent nuclear fuel (SNF) that has lost its original technical and functional design capabilities with regard to handling and confinement can be considered as damaged. Some SNF was damaged as a result of experimental activities and destructive examinations; incidents during packaging, handling, and transportation; or degradation that has occurred during storage. Some SNF was mechanically destroyed to protect proprietary SNF designs. Examples of damage to the SNF include failed cladding, failed fuel meat, sectioned test specimens, partially reprocessed SNFs, over-heated elements, dismantled assemblies, and assemblies with lifting fixtures removed. In spite of the challenges involved with handling and storage of damaged SNF, the SNF has been safely handled and stored for many years at DOE storage facilities. This report summarizes a variety of challenges encountered at DOE facilities during interim storage and handling operations along with strategies and solutions that are planned or were implemented to ameliorate those challenges. A discussion of proposed paths forward for moving damaged and nondamaged SNF from interim storage to final disposition in the geologic repository is also presented

  10. The order for enforcing the law concerning indemnification of nuclear damage

    International Nuclear Information System (INIS)

    1980-01-01

    The cabinet ordinance is established under the law concerning the indemnification for atomic energy damages. The matters stipulated by the ordinance in the law include the following matters: the operation of reactors; the processing of nuclear fuel materials, such as uranium 235, specified uranium and its compounds, plutonium and its compounds, etc.; reprocessing; the employment of such nuclear fuel materials; the transportation, storage and disposal of such materials, particular spent fuels and the things contaminated by nuclear fuel materials, which occur according to the operation of reactors and other practices above mentioned. The amounts of indemnification are respectively 10 billion yen for the operation of reactors whose thermal outputs are more than 10,000 kilowatts and reprocessing, 2 billion yen for the operation of reactors whose thermal outputs are more than 100 kilowatts and less than 10,000 kilowatts and the transportation of spent fuel accompanying the operation of reactors or reprocessing, 200 million yen for the operation of reactors whose thermal outputs are less than 100 kilowatts, and the processing and employment of nuclear fuel materials, the transportation of nuclear fuel materials accompanying the operation of reactors, and the processing, reprocessing and employment of nuclear fuel materials. The payment of casualty indemnification includes that according to the provisions of the government official casualty indemnification law and that due to official causes under the provisions of the seamen insurance law. (Okada, K.)

  11. A quantitative 14-3-3 interaction screen connects the nuclear exosome targeting complex to the DNA damage response

    DEFF Research Database (Denmark)

    Blasius, Melanie; Wagner, Sebastian A; Choudhary, Chuna Ram

    2014-01-01

    RNA metabolism is altered following DNA damage, but the underlying mechanisms are not well understood. Through a 14-3-3 interaction screen for DNA damage-induced protein interactions in human cells, we identified protein complexes connected to RNA biology. These include the nuclear exosome...

  12. Nondestructive Evaluation of Functionally Graded Subsurface Damage on Cylinders in Nuclear Installations Based on Circumferential SH Waves

    Directory of Open Access Journals (Sweden)

    Zhen Qu

    2016-01-01

    Full Text Available Subsurface damage could affect the service life of structures. In nuclear engineering, nondestructive evaluation and detection of the evaluation of the subsurface damage region are of great importance to ensure the safety of nuclear installations. In this paper, we propose the use of circumferential horizontal shear (SH waves to detect mechanical properties of subsurface regions of damage on cylindrical structures. The regions of surface damage are considered to be functionally graded material (FGM and the cylinder is considered to be a layered structure. The Bessel functions and the power series technique are employed to solve the governing equations. By analyzing the SH waves in the 12Cr-ODS ferritic steel cylinder, which is frequently applied in the nuclear installations, we discuss the relationship between the phase velocities of SH waves in the cylinder with subsurface layers of damage and the mechanical properties of the subsurface damaged regions. The results show that the subsurface damage could lead to decrease of the SH waves’ phase velocity. The gradient parameters, which represent the degree of subsurface damage, can be evaluated by the variation of the SH waves’ phase velocity. Research results of this study can provide theoretical guidance in nondestructive evaluation for use in the analysis of the reliability and durability of nuclear installations.

  13. High dose radiation damage in nuclear energy structural materials investigated by heavy ion irradiation simulation

    International Nuclear Information System (INIS)

    Zheng Yongnan; Xu Yongjun; Yuan Daqing

    2014-01-01

    Structural materials in ITER, ADS and fast reactor suffer high dose irradiations of neutrons and/or protons, that leads to severe displacement damage up to lOO dpa per year. Investigation of radiation damage induced by such a high dose irradiation has attracted great attention along with the development of nuclear energy facilities of new generation. However, it is deeply hampered for the lacking of high dose neutron and proton sources. Irradiation simulation of heavy ions produced by accelerators opens up an effective way for laboratory investigation of high dose irradiation induced radiation damage encountered in the ITER, ADS, etc. Radiation damage is caused mainly by atomic displacement in materials. The displacement rate of heavy ions is about lO 3 ∼10 7 orders higher than those of neutrons and protons. High displacement rate of heavy ions significantly reduces the irradiation time. The heavy ion irradiation simulation technique (HIIS) technique has been developed at China Institute of Atomic Energy and a series of the HIIS experiments have been performed to investigate radiation damage in stainless steels, tungsten and tantalum at irradiation temperatures from room temperature to 800 ℃ and in the irradiation dose region up to 100 dpa. The experimental results show that he radiation swelling peak for the modified stainless steel appears in the temperature region around 580 ℃ and the radiation damage is more sensitive to the temperature, the size of the radiation induced vacancy cluster or void increase with the increasing of the irradiation dose, and among the three materials the home-made modified stainless steel has the best radiation resistant property. (authors)

  14. Radiation damage studies in nuclear waste storage matrices: a few remarks

    International Nuclear Information System (INIS)

    Limoge, Y.

    1997-01-01

    For safe management of high level nuclear waste (HLNW) we have to predict the behaviour of the storage matrix that will have to sustain irradiation over a long period of 10 4 to 10 5 years. 2 approaches are possible and in fact complementary. The first approach is an experimental one: the selected material is submitted to an acceleration of the damage by using various forms of external or internal radiations delivering a higher flux than the stored wastes themselves. The second approach is a cognitive one that requires the modelling of the radiation damage. The second approach seems to have been less developed than the first one. The second approach is a multi-step one. The first step is to review and model all possible phenomena occurring in irradiated material. The second step is to review the different kinds of defects produced by irradiation, their possible mutual interaction and their elimination modes that are followed by the material to go back to equilibrium. There have been a lot of detailed studies of defect formation under ionizing conditions in silica and simple silica based glass, mainly for electronic industry purposes. Fewer studies have been done on nuclear glasses. This article makes a point about the necessity and need for reliable simulation of long-term irradiation effects on nuclear glasses

  15. Review of the Shoreham Nuclear Power Station Probabilistic Risk Assessment: internal events and core damage frequency

    International Nuclear Information System (INIS)

    Ilberg, D.; Shiu, K.; Hanan, N.; Anavim, E.

    1985-11-01

    A review of the Probabilistic Risk Assessment of the Shoreham Nuclear Power Station was conducted with the broad objective of evaluating its risks in relation to those identified in the Reactor Safety Study (WASH-1400). The scope of the review was limited to the ''front end'' part, i.e., to the evaluation of the frequencies of states in which core damage may occur. Furthermore, the review considered only internally generated accidents, consistent with the scope of the PRA. The review included an assessment of the assumptions and methods used in the Shoreham study. It also encompassed a reevaluation of the main results within the scope and general methodological framework of the Shoreham PRA, including both qualitative and quantitative analyses of accident initiators, data bases, and accident sequences which result in initiation of core damage. Specific comparisons are given between the Shoreham study, the results of the present review, and the WASH-1400 BWR, for the core damage frequency. The effect of modeling uncertainties was considered by a limited sensitivity study so as to show how the results would change if other assumptions were made. This review provides an independently assessed point value estimate of core damage frequency and describes the major contributors, by frontline systems and by accident sequences. 17 figs., 81 tabs

  16. Damage-plasticity model of the host rock in a nuclear waste repository

    Energy Technology Data Exchange (ETDEWEB)

    Koudelka, Tomáš; Kruis, Jaroslav, E-mail: kruis@fsv.cvut.cz [Department of Mechanics, Faculty of Civil Engineering, Czech Technical University in Prague, Thákurova 7, 166 29 Prague (Czech Republic)

    2016-06-08

    The paper describes damage-plasticity model for the modelling of the host rock environment of a nuclear waste repository. Radioactive Waste Repository Authority in Czech Republic assumes the repository to be in a granite rock mass which exhibit anisotropic behaviour where the strength in tension is lower than in compression. In order to describe this phenomenon, the damage-plasticity model is formulated with the help of the Drucker-Prager yield criterion which can be set to capture the compression behaviour while the tensile stress states is described with the help of scalar isotropic damage model. The concept of damage-plasticity model was implemented in the SIFEL finite element code and consequently, the code was used for the simulation of the Äspö Pillar Stability Experiment (APSE) which was performed in order to determine yielding strength under various conditions in similar granite rocks as in Czech Republic. The results from the performed analysis are presented and discussed in the paper.

  17. The principle of proportionateness in the nuclear law to provide against damage

    International Nuclear Information System (INIS)

    Marburger, P.

    1983-01-01

    The author explains the principle of proportionateness as applied in licensing procedures for nuclear installations to provide against damage, as required by section 7, sub-section (2), no. 3 of the Atomic Energy Act. He stated that in his opinion, the appropriateness as an important element of the principle of proportionateness in the law pertaining to technical safety calls for a balanced evaluation so that in principle, additional safety requirements ought to be set only if they undoubtedly bring about additional improvements, improvements that clearly outweigh any disadvantages. This, he said, is also the opinion of the Federal Constitutional Court, as expressed in the indicial declaration of law. Appropriate consideration is also to be given to economic aspects (risk/cost evaluations) when deciding upon appropriate measures to provide against damage. (WB) [de

  18. The effect of uncertainties in nuclear reactor plant-specific failure data on core damage frequency

    International Nuclear Information System (INIS)

    Martz, H.F.

    1995-05-01

    It is sometimes the case in PRA applications that reported plant-specific failure data are, in fact, only estimates which are uncertain. Even for detailed plant-specific data, the reported exposure time or number of demands is often only an estimate of the actual exposure time or number of demands. Likewise the reported number of failure events or incidents is sometimes also uncertain because incident or malfunction reports may be ambiguous. In this report we determine the corresponding uncertainty in core damage frequency which can b attributed to such uncertainties in plant-specific data using a simple but typical nuclear power reactor example

  19. Study of DNA damage with a new system for irradiation of samples in a nuclear reactor

    Energy Technology Data Exchange (ETDEWEB)

    Gual, Maritza R., E-mail: mrgual@instec.c [Instituto Superior de Tecnologias y Ciencias Aplicadas, InSTEC, Avenida Salvador Allende y Luaces, Quinta de Los Molinos, Plaza de la Revolucion, Havana, AP 6163 (Cuba); Milian, Felix M. [Universidade Estadual de Santa Cruz, UESC (Brazil); Deppman, Airton [Instituto de Fisica, Universidad de Sao Paulo, IF-USP, Rua do Matao, Travessa R, no. 187, Ciudade Universitaria, Butanta, CEP 05508-900, Sao Paulo (Brazil); Coelho, Paulo R.P. [Instituto de Pesquisas Energeticas e Nucleares, IPEN-CNEN/SP (Brazil)

    2011-02-15

    In this paper, we report results of a quantitative analysis of the effects of neutrons on DNA, and, specifically, the production of simple and double breaks of plasmid DNA in aqueous solutions with different concentrations of free-radical scavengers. The radiation damage to DNA was evaluated by electrophoresis through agarose gels. The neutron and gamma doses were measured separately with thermoluminescent detectors. In this work, we have also demonstrated usefulness of a new system for positioning and removing samples in channel BH3 of the IEA-R1 reactor at the Instituto de Pesquisas Energeticas e Nucleares (Brazil) without necessity of interrupting the reactor operation.

  20. Equipment for testing a group of nuclear reactor fuel elements for damage to the cans

    International Nuclear Information System (INIS)

    Mohm, F.

    1977-01-01

    Equipment is described for use in sodium cooled nuclear reactors, with which the fuel elements consisting of bundles of fuel and fertile rods can be examined for damage to the cans. Fission poducts occurring in the liquid coolant act as indicators. The coolant is sucked via pipelines which penetrate into the elements into a collecting container, and a special pipeline is available for every element of a group, where the highest points of individual pipelines at different hydrostatic heads are taken to the collecting container. This permits the checking of one line at a time due to pressure changes. (UWI) [de

  1. Accident prevention and security measures to prevent intentional harm and damage through nuclear energy

    International Nuclear Information System (INIS)

    Rauschning, D.

    1984-01-01

    The author explains the authorities' duty to provide for protection against intentional damage or physical harm through the use of nuclear energy. It belongs to the competence of the various authorities to define ways and means to afford protection, and to establish an appropriate network of provisions. There are provisions belonging to criminal law, those concerning liability and indemnity, and security regulations incorporated in the law on licensing and supervision. The author presents a detailed account of the law applicable and discusses the conflict of interests between governmental duties and intentions and the civil rights of the individual affected by the provisions. (HSCH) [de

  2. Analysis of simulation results of damaged nuclear fuel accidents at NPPs with shell-type nuclear reactors

    Directory of Open Access Journals (Sweden)

    Igor L. Kozlov

    2015-03-01

    Full Text Available Lessons from the accident at the Fukushima Daiichi NPP made it necessary to reevaluate and intensificate the work on modeling and analyzing various scenarios of severe accidents with damage to the nuclear fuel in the reactor, containment and spent nuclear fuel storage pool with the expansion of the primary initiating event causes group listing. Further development of computational tools for modeling the explosion prevention criteria as to steam and gas mixtures, considering the specific thermal-hydrodynamic conditions and mechanisms of explosive situations arrival at different stages of a severe accident development, is substantiated. Based on the analysis of the known shell-type nuclear reactors accidents results the explosion safety thermodynamic criteria are presented, the parameters defining the steam and gas explosions conditions are found, the need to perform the further verification and validation of deterministic codes serving to simulate general accident processes behavior as well as phase-to-phase interaction calculated dependencies is established. The main parameters controlling and defining the criteria explosion safety effective regulation areas and their optimization conditions are found.

  3. Notes on third party liability for nuclear damage in connection with the construction of the first nuclear power plant in Brazil

    International Nuclear Information System (INIS)

    Simoes, A.C.

    1975-01-01

    Responsibilities for the construction and operation of the first nuclear power plant have been transferred from the National Nuclear Energy Commission to Electrobras, a public undertaking set up for this purpose. In view of such transfer of responsibilities and the implementation of further nuclear power projects, liability for nuclear damage has to be regulated in a way consistent with international conventions. A working group associating representatives of national authorities and public utilities was entrusted with the task of drafting rules for co-ordinating their respective activities in relation to the execution of the first nuclear power project; these rules were issued by Ministerial order in 1970. The working group also prepared a draft law on civil liability for nuclear damage, based on the Vienna Convention. This draft law has reached its final stage and, after promulgation, will enable Brazil to ratify the Vienna Convention. (author)

  4. Oxidative damage of mitochondrial and nuclear DNA induced by ionizing radiation in human hepatoblastoma cells

    International Nuclear Information System (INIS)

    Morales, Albert; Miranda, Merce; Sanchez-Reyes, Alberto; Biete, Alberto; Fernandez-Checa, Jose C.

    1998-01-01

    Purpose: Since reactive oxygen species (ROS) act as mediators of radiation-induced cellular damage, the aim of our studies was to determine the effects of ionizing radiation on the regulation of hepatocellular reduced glutathione (GSH), survival and integrity of nuclear and mitochondrial DNA (mtDNA) in human hepatoblastoma cells (Hep G2) depleted of GSH prior to radiation. Methods and Materials: GSH, oxidized glutathione (GSSG), and generation of ROS were determined in irradiated (50-500 cGy) Hep G2 cells. Clonogenic survival, nuclear DNA fragmentation, and integrity of mtDNA were assessed in cells depleted of GSH prior to radiation. Results: Radiation of Hep G2 cells (50-400 cGy) resulted in a dose-dependent generation of ROS, an effect accompanied by a decrease of reduced GSH, ranging from a 15% decrease for 50 cGy to a 25% decrease for 400 cGy and decreased GSH/GSSG from a ratio of 17 to a ratio of 7 for controls and from 16 to 6 for diethyl maleate (DEM)-treated cells. Depletion of GSH prior to radiation accentuated the increase of ROS by 40-50%. The depletion of GSH by radiation was apparent in different subcellular sites, being particularly significant in mitochondria. Furthermore, depletion of nuclear GSH to 50-60% of initial values prior to irradiation (400 cGy) resulted in DNA fragmentation and apoptosis. Consequently, the survival of Hep G2 to radiation was reduced from 25% of cells not depleted of GSH to 10% of GSH-depleted cells. Fitting the survival rate of cells as a function of GSH using a theoretical model confirmed cellular GSH as a key factor in determining intrinsic sensitivity of Hep G2 cells to radiation. mtDNA displayed an increased susceptibility to the radiation-induced loss of integrity compared to nuclear DNA, an effect that was potentiated by GSH depletion in mitochondria (10-15% intact mtDNA in GSH-depleted cells vs. 25-30% of repleted cells). Conclusion: GSH plays a critical protective role in maintaining nuclear and mtDNA functional

  5. The regulation for enforcing the law concerning indemnification of nuclear damage

    International Nuclear Information System (INIS)

    1978-01-01

    These provisions are established on the basis of and to enforce the ''Law concerning the indemnification of nuclear damage''. Atomic energy enterprises who want to get the approval in connection with the Law shall file the applications to the Director General of Science and Technology Agency, in which the name and the address of the applicant, kinds of the operation of nuclear reactors, the name and the address of the factory or the establishment concerning the operation of nuclear reactors, the thermal output of the reactors, the kinds and quantities of nuclear fuel materials or the things contaminated by such materials to be transported, and the time of starting and the expected time of ending the operation of the reactors, etc. To such applications, shall be attached actually surveyed maps indicating the area of the factory or the establishment concerning the operation of the reactors and the documents certifying the conclusion of obligatory insurances and indemnification contracts, etc. The securities which can be deposited and recovering of such securities are prescribed. (Okada, K.)

  6. Act No 6453 of 17th October, 1977 on civil liability for nuclear damage and criminal responsibility for acts relating to nuclear activities, and other provisions

    International Nuclear Information System (INIS)

    1978-01-01

    This Act was published on 17 October 1977. It is based to a great extent on the provisions of the Vienna Convention on Civil Liability for Nucler Damage of 21 May 1963. Under the Act the operator of a nuclear installation is exclusively liable regardless of fault for compensation of nuclear damage due to a nuclear incident. This exclusive liability is limited to an amount equal to 1,500,000 Treasury Bonds and the operator must take out and maintain insurance or other financial security to cover his liability. The Federative Government will guarantee, up to the prescribed limit, payment of compensation for nuclear damage where it is acknowledged that the operator's liability is involved. As regards apportionment of compensation, persons are granted priority over property. This Act is original in that it contains provisions on criminal liability with penalties ranging from two to ten years imprisonment. (NEA) [fr

  7. Questions raised by the concept of nuclear damage in the ambit of the nuclear Conventions with particular regard to the German viewpoint

    International Nuclear Information System (INIS)

    Steinkemper, H.

    1985-01-01

    An important consequence of the amendment of the Paris Convention and the Brussels Supplementary Convention by the Protocols of 16 November 1982 is the replacement of the European Monetary Agreement unit of account by the International Monetary Fund's Special Drawing Right. The increase by a factor of 2.5 of the maximum amounts under the Brussels Convention is also an essential aspect of the revision. The question of damage covered by the nuclear third party liability regime was not affected by the 1982 amendments. This is why the author considers it appropriate to examine in further detail a number of important questions in this field. The paper deals with the following aspects: the scope and limits of the concept of nuclear damage; the right to be indemnified for disamenities and costs arising from evacuation and prevention measures; and the problem of the nuclear link of causality for damage likely to be attributed also to non-nuclear causes. (NEA) [fr

  8. Probabilistic analysis of turbine missile damage to nuclear power plant structures

    International Nuclear Information System (INIS)

    Twisdale, L.A.; Dunn, W.L.; Frank, R.A.

    1983-01-01

    This paper summarizes the results of the EPRI project that focused on the development of the overall probabilistic methodology to assess the risks of turbine missile induced damage to nuclear power plant structures and components. The project was structured to use the results of other EPRI projects that provided information on turbine failure and missile generation frequencies, models to predict the characteristics and exit conditions of the missiles, and experimental data for use in updating empirical impact formulas for reinforced concrete barriers. The research effort included: (1) adaptation and implementation of the missile generation probability and turbine casing impact models developed in Ref. [2]; (2) development of a methodology for the prediction of the motion of the postulated missile fragments that perforate the turbine casing; (3) development of a model using the experimental impact data to predict the effects of fragment impact on nuclear power plant barriers and components; (4) construction of a probabilistic damage assessment methodology using Monte Carlo simulation methodology; and (5) implementation of the methodology into an independent computer program (TURMIS), demonstration of its application to an example case study problem, and assessment of prediction sensitivity. (orig./RW)

  9. The usefulness of the nuclear cardiology in the cellular implant in patients with severe myocardial damage

    International Nuclear Information System (INIS)

    Omelas A, M.; Arguero S, R.; Garrido G, M.H.; Rodriguez C, A.; Careaga, G.; Castano G, R.; Nambo, M.J.; Pascual P, J.; Ortega R, A.; Gaxiola A, A.; Magana S, J.A.; Estrada A, H.; Equipo de Tecnicos en Medicina Nuclear

    2005-01-01

    The recent therapeutic advances as the cellular implant as well as those different protocols of image acquisition in the field of the Nuclear Cardiology its have allowed that the patient with severe myocardial damage and without some possibility of revascularization is benefited with these advances. Doubtless the Tl-201 par excellence has an important paper for standardize the more appropriate therapeutic behavior for the heart attack patient; reason by this investigation protocol was developed. The objective of the study was to identify the heart attack regions without viable tissue with SPECT in patient with important myocardial damage without some possibility of traditional revascularization; for the 'Stem cell' cellular implantation therapy. The methodology it was carried out by a study of myocardial perfusion in 10 patients with important myocardial damage previous cellular implants, with PICANUC/ SPECT methodology and using a software (Emory Tool Box) for the image processing validated by the University of Emory Atlanta GA; and using as tracer the Tl - 201 to identify the heart attack regions without presence of viable tissue with an analysis model of 17 segments standardized for the left ventricle; qualifying this way the myocardial perfusion in: 0 (normal), 1 (light), 2 (moderate), 3 (severe), 4 (absent) and x (bad technique). The conclusions were that the SPECT study with PICANUC methodology with Tl-201 is safe and effective for the precise localization for the cellular implantation via direct intra myocardial. (Author)

  10. Displacement damage effects on CMOS APS image sensors induced by neutron irradiation from a nuclear reactor

    International Nuclear Information System (INIS)

    Wang, Zujun; Huang, Shaoyan; Liu, Minbo; Xiao, Zhigang; He, Baoping; Yao, Zhibin; Sheng, Jiangkun

    2014-01-01

    The experiments of displacement damage effects on CMOS APS image sensors induced by neutron irradiation from a nuclear reactor are presented. The CMOS APS image sensors are manufactured in the standard 0.35 μm CMOS technology. The flux of neutron beams was about 1.33 × 10 8 n/cm 2 s. The three samples were exposed by 1 MeV neutron equivalent-fluence of 1 × 10 11 , 5 × 10 11 , and 1 × 10 12 n/cm 2 , respectively. The mean dark signal (K D ), dark signal spike, dark signal non-uniformity (DSNU), noise (V N ), saturation output signal voltage (V S ), and dynamic range (DR) versus neutron fluence are investigated. The degradation mechanisms of CMOS APS image sensors are analyzed. The mean dark signal increase due to neutron displacement damage appears to be proportional to displacement damage dose. The dark images from CMOS APS image sensors irradiated by neutrons are presented to investigate the generation of dark signal spike

  11. Fatigue damage evaluation of stainless steel pipes in nuclear power plants using positron annihilation lineshape analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kawaguchi, Yasuhiro [Institute of Nuclear Safety System, Inc., Mihama, Fukui (Japan); Nakamura, Noriko; Yusa, Satoru [Ishikawajima-Harima Heavy Industries Co., Tokyo (Japan)

    2002-09-01

    Since positron annihilation lineshape analysis can evaluate the degree of fatigue damage by detecting defects such as dislocations in metals, we applied this method to evaluate that in a type 316 stainless steel pipe which was used in the primary system of a nuclear power plant. Using {sup 68}Ge as a positron source, an energy spread of annihilation gamma ray peak from the material was measured and expressed as the S-parameter. Actual plant material cut from a surge line pipe of a pressurizer in a pressurized water reactor type nuclear power plant was measured by positron annihilation lineshape analysis and the S-parameter was obtained. Comparing the S-parameter with a relationship between the S-parameter and fatigue life ratio of the type 316 stainless steel, we evaluated the degree of fatigue damage of the actual material. Furthermore, to verify the evaluation, microstructures of the actual material were investigated with TEM (transmission electron microscope) to observe dislocation densities. As a result, a change in the S-parameter of the actual material from standard as-received material (type 316 stainless steel) was in the range from -0.0013 to 0.0014, while variations in the S-parameter of the standard as-received material were about {+-}0.002, and hence the differences between the actual material and the as-received material were negligible. Moreover, the dislocation density of the actual plant material observed with TEM was almost the same as that of the as-received one. In conclusion, we could confirm the applicability of the positron annihilation lineshape analysis to fatigue damage evaluation of stainless steel. (author)

  12. Glutathione-deficient Plasmodium berghei parasites exhibit growth delay and nuclear DNA damage.

    Science.gov (United States)

    Padín-Irizarry, Vivian; Colón-Lorenzo, Emilee E; Vega-Rodríguez, Joel; Castro, María Del R; González-Méndez, Ricardo; Ayala-Peña, Sylvette; Serrano, Adelfa E

    2016-06-01

    Plasmodium parasites are exposed to endogenous and exogenous oxidative stress during their complex life cycle. To minimize oxidative damage, the parasites use glutathione (GSH) and thioredoxin (Trx) as primary antioxidants. We previously showed that disruption of the Plasmodium berghei gamma-glutamylcysteine synthetase (pbggcs-ko) or the glutathione reductase (pbgr-ko) genes resulted in a significant reduction of GSH in intraerythrocytic stages, and a defect in growth in the pbggcs-ko parasites. In this report, time course experiments of parasite intraerythrocytic development and morphological studies showed a growth delay during the ring to schizont progression. Morphological analysis shows a significant reduction in size (diameter) of trophozoites and schizonts with increased number of cytoplasmic vacuoles in the pbggcs-ko parasites in comparison to the wild type (WT). Furthermore, the pbggcs-ko mutants exhibited an impaired response to oxidative stress and increased levels of nuclear DNA (nDNA) damage. Reduced GSH levels did not result in mitochondrial DNA (mtDNA) damage or protein carbonylations in neither pbggcs-ko nor pbgr-ko parasites. In addition, the pbggcs-ko mutant parasites showed an increase in mRNA expression of genes involved in oxidative stress detoxification and DNA synthesis, suggesting a potential compensatory mechanism to allow for parasite proliferation. These results reveal that low GSH levels affect parasite development through the impairment of oxidative stress reduction systems and damage to the nDNA. Our studies provide new insights into the role of the GSH antioxidant system in the intraerythrocytic development of Plasmodium parasites, with potential translation into novel pharmacological interventions. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  13. MAP kinase-signaling controls nuclear translocation of tripeptidyl-peptidase II in response to DNA damage and oxidative stress

    Energy Technology Data Exchange (ETDEWEB)

    Preta, Giulio; Klark, Rainier de; Chakraborti, Shankhamala [Center for Molecular Medicine (CMM), Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm (Sweden); Glas, Rickard, E-mail: rickard.glas@ki.se [Center for Molecular Medicine (CMM), Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm (Sweden)

    2010-08-27

    Research highlights: {yields} Nuclear translocation of TPPII occurs in response to different DNA damage inducers. {yields} Nuclear accumulation of TPPII is linked to ROS and anti-oxidant enzyme levels. {yields} MAPKs control nuclear accumulation of TPPII. {yields} Inhibited nuclear accumulation of TPPII decreases DNA damage-induced {gamma}-H2AX expression. -- Abstract: Reactive oxygen species (ROS) are a continuous hazard in eukaroytic cells by their ability to cause damage to biomolecules, in particular to DNA. Previous data indicated that the cytosolic serine peptidase tripeptidyl-peptidase II (TPPII) translocates into the nucleus of most tumor cell lines in response to {gamma}-irradiation and ROS production; an event that promoted p53 expression as well as caspase-activation. We here observed that nuclear translocation of TPPII was dependent on signaling by MAP kinases, including p38MAPK. Further, this was caused by several types of DNA-damaging drugs, a DNA cross-linker (cisplatinum), an inhibitor of topoisomerase II (etoposide), and to some extent also by nucleoside-analogues (5-fluorouracil, hydroxyurea). In the minority of tumor cell lines where TPPII was not translocated into the nucleus in response to DNA damage we observed reduced intracellular ROS levels, and the expression levels of redox defense systems were increased. Further, treatment with the ROS-inducer {gamma}-hexa-chloro-cyclohexane ({gamma}-HCH, lindane), an inhibitor of GAP junctions, restored nuclear translocation of TPPII in these cell lines upon {gamma}-irradiation. Moreover, blocking nuclear translocation of TPPII in etoposide-treated cells, by using a peptide-derived inhibitor (Z-Gly-Leu-Ala-OH), attenuated expression of {gamma}-H2AX in {gamma}-irradiated melanoma cells. Our results indicated a role for TPPII in MAPK-dependent DNA damage signaling.

  14. The regulation for enforcing the law concerning indemnification of nuclear damage

    International Nuclear Information System (INIS)

    1980-01-01

    The regulation is set up under the provisions of the law concerning the indemnification for atomic energy damages, to enforce them. An atomic energy business enterpriser who intends to get the approval of indemnification measures specified under the law shall file an application to the General Director of the Science Technology Agency, attaching particular documents and writing the following matters: his name and address; the kinds of operation of reactors; the names and addresses of works or places of business where reactors are operated; the thermal output of reactors; the kinds and quantities of nuclear fuel materials processed or employed; the kinds and quantities of nuclear fuel materials or contaminated materials to be transported; the kinds and quantities of nuclear fuel materials or contaminated materials to be disposed; beginning dates and expected ending dates of the operation of reactors; and other items stipulated concerning liability insurance and indemnification contracts. The negotiable securities qualified to be trusted include government bonds; municipal bonds; bonds issued by particular legal persons; bonds issued by banks, Central Cooperative Bank for Agriculture and Forestry, or Bank for Commerce and Industrial Cooperatives, and secured debentures under the secured debenture trust law. The recovering of trusted securities and identification cards are defined, respectively. (Okada, K.)

  15. Act No. 225 of 17 March 1979 containing regulations on third party liability for damage caused by nuclear incidents; Nuclear Incidents (Third Party Liability) Act

    International Nuclear Information System (INIS)

    1979-01-01

    This Act on nuclear third party liability provides that the maximum amount of liability of the operator of a nuclear installation in the Netherlands is set at 100 million guilders in accordance with the Paris Convention; it also implements the Brussels Supplementary Convention's additional compensation mechanism. The new Act further provides that if damage is suffered on the Netherlands' territory as a result of a nuclear incident for which compensation is payable pursuant to the Brussels Convention or to the Act, and that the funds available for this purpose are insufficient to secure compensation of such damage to an amount of one thousand million guilders, the State shall make available the public funds needed to compensate such damage up to that amount. (NEA) [fr

  16. Radiation Damage in Nuclear Fuel for Advanced Burner Reactors: Modeling and Experimental Validation

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, Niels Gronbech; Asta, Mark; Ozolins, Nigel Browning' Vidvuds; de Walle, Axel van; Wolverton, Christopher

    2011-12-29

    The consortium has completed its existence and we are here highlighting work and accomplishments. As outlined in the proposal, the objective of the work was to advance the theoretical understanding of advanced nuclear fuel materials (oxides) toward a comprehensive modeling strategy that incorporates the different relevant scales involved in radiation damage in oxide fuels. Approaching this we set out to investigate and develop a set of directions: 1) Fission fragment and ion trajectory studies through advanced molecular dynamics methods that allow for statistical multi-scale simulations. This work also includes an investigation of appropriate interatomic force fields useful for the energetic multi-scale phenomena of high energy collisions; 2) Studies of defect and gas bubble formation through electronic structure and Monte Carlo simulations; and 3) an experimental component for the characterization of materials such that comparisons can be obtained between theory and experiment.

  17. The regulation for enforcing the law concerning indemnification of nuclear damage

    International Nuclear Information System (INIS)

    1977-01-01

    The atomic energy entrepreneurs wishing to obtain the approval according to Item 1, Article 7 of the Law Concerning Indemnification of Nuclear Damage should file application (one original and one duplicate) describing the following items to the Director of the Science and Technology Agency: (1) in case of taking indemnification measures including the conclusion of responsibility insurance contracts and indemnification contracts, the particulars of the contracts including the sum of money involved, (2) in case of taking indemnification measures including deposit, the particulars of the deposit including the sum of money involved, and (3) in case of taking loss indemnification measures including the conclusion of responsibility insurance contracts and indemnification contracts or other measures than deposit, the particulars of such measures. (Rikitake, Y.)

  18. Detecting Structural Damage of Nuclear Power Plant by Interactive Data Mining Approach

    International Nuclear Information System (INIS)

    Yufei Shu

    2006-01-01

    This paper presents a nonlinear structural damage identification technique, based on an interactive data mining approach, which integrates a human cognitive model in a data mining loop. A mining control agent emulating human analysts is developed, which directly interacts with the data miner, analyzing and verifying the output of the data miner and controlling the data mining process. Additionally, an artificial neural network method, which is adopted as a core component of the proposed interactive data mining method, is evolved by adding a novelty detecting and retraining function for handling complicated nuclear power plant quake-proof data. Plant quake-proof testing data has been applied to the system to show the validation of the proposed method. (author)

  19. Tracking of Airborne Radionuclides from the Damaged Fukushima Dai-Ichi Nuclear Reactors by European Networks

    DEFF Research Database (Denmark)

    Masson, O.; Baeza, A.; Bieringer, J.

    2011-01-01

    Radioactive emissions into the atmosphere from the damaged reactors of the Fukushima Dai-ichi nuclear power plant (NPP) started on March 12th, 2011. Among the various radionuclides released, iodine-131 (131I) and cesium isotopes (137Cs and 134Cs) were transported across the Pacific toward the North...... period and spatial variations across more than 150 sampling locations in Europe made it possible to characterize the contaminated air masses. After the Chernobyl accident, only a few measurements of the gaseous 131I fraction were conducted compared to the number of measurements for the particulate...... reactors have provided a significant amount of new data on the ratio of the gaseous 131I fraction to total 131I, both on a spatial scale and its temporal variation. It can be pointed out that during the Fukushima event, the 134Cs to 137Cs ratio proved to be different from that observed after the Chernobyl...

  20. Fundamental Processes of Coupled Radiation Damage and Mechanical Behavior in Nuclear Fuel Materials for High Temperature Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Phillpot, Simon; Tulenko, James

    2011-09-08

    The objective of this work has been to elucidate the relationship among microstructure, radiation damage and mechanical properties for nuclear fuel materials. As representative nuclear materials, we have taken an hcp metal (Mg as a generic metal, and Ti alloys for fast reactors) and UO2 (representing fuel). The degradation of the thermo-mechanical behavior of nuclear fuels under irradiation, both the fissionable material itself and its cladding, is a longstanding issue of critical importance to the nuclear industry. There are experimental indications that nanocrystalline metals and ceramics may be more resistant to radiation damage than their coarse-grained counterparts. The objective of this project look at the effect of microstructure on radiation damage and mechanical behavior in these materials. The approach to be taken was state-of-the-art, large-scale atomic-level simulation. This systematic simulation program of the effects of irradiation on the structure and mechanical properties of polycrystalline Ti and UO2 identified radiation damage mechanisms. Moreover, it will provided important insights into behavior that can be expected in nanocrystalline microstructures and, by extension, nanocomposites. The fundamental insights from this work can be expected to help in the design microstructures that are less susceptible to radiation damage and thermomechanical degradation.

  1. Fundamental Processes of Coupled Radiation Damage and Mechanical Behavior in Nuclear Fuel Materials for High Temperature Reactors

    International Nuclear Information System (INIS)

    Phillpot, Simon; Tulenko, James

    2011-01-01

    The objective of this work has been to elucidate the relationship among microstructure, radiation damage and mechanical properties for nuclear fuel materials. As representative nuclear materials, we have taken an hcp metal (Mg as a generic metal, and Ti alloys for fast reactors) and UO2 (representing fuel). The degradation of the thermo-mechanical behavior of nuclear fuels under irradiation, both the fissionable material itself and its cladding, is a longstanding issue of critical importance to the nuclear industry. There are experimental indications that nanocrystalline metals and ceramics may be more resistant to radiation damage than their coarse-grained counterparts. The objective of this project look at the effect of microstructure on radiation damage and mechanical behavior in these materials. The approach to be taken was state-of-the-art, large-scale atomic-level simulation. This systematic simulation program of the effects of irradiation on the structure and mechanical properties of polycrystalline Ti and UO2 identified radiation damage mechanisms. Moreover, it will provided important insights into behavior that can be expected in nanocrystalline microstructures and, by extension, nanocomposites. The fundamental insights from this work can be expected to help in the design microstructures that are less susceptible to radiation damage and thermomechanical degradation.

  2. Law no. 6.453 of 17th October, 1977 on civil liability for nuclear damage and criminal responsibility for acts relating to nuclear activities, and other provisions

    International Nuclear Information System (INIS)

    1977-01-01

    This Act was published on 17 october 1977. Under the Act the operator of a nuclear installation is exclusively liable regardless of fault for compensation of nuclear damage due to a nuclear incident. This exclusive liability is limited to an amount equal to 1,500,000 Treasury Bonds and the operator must take out the maintain insurance or other financial security to cover his liability. The Federative Government will guarantee, up to the prescribed limit, payment of compensation for nuclear damage where it is acknowledged that the operator's liability is involved. As regards apportionment of compensation, persons are granted priority over property. This Act is original in that it contains provisions on criminal liability with penalties ranging from two to ten years imprisonment

  3. Three technical issues in fatigue damage assessment of nuclear power plant components

    International Nuclear Information System (INIS)

    Ware, A.G.; Shah, V.N.

    1991-01-01

    This paper addresses three technical issues that affect the fatigue damage assessment of nuclear power plant components: the effect of the environment on the fatigue life, the importance of the loading sequence in calculating the fatigue crack-initiation damage, and the adequacy of current inservice inspection requirements and methods to characterize fatigue cracks. The environmental parameters that affect the fatigue life of carbon and low alloy steel components are the sulphur content in the steel, the temperature, the amount of dissolved oxygen in the coolant, and the presence of oxidizing agents such as copper oxide. The occurrence of large-amplitude stress cycles early in a component's life followed by low-amplitude stress cycles may cause crack initiation at a cumulative usage factor less than 1.0. The current inservice inspection requirements include volumetric inspections of welds but not of some susceptible sites in the base metal. In addition, the conventional ultrasonic testing techniques need to be improved for reliable detection and accurate sizing of fatigue cracks. 28 refs., 4 figs., 1 tab

  4. Review of legislation on civil liability for nuclear damage; Revision de la legislacion relativa a la responsabilidad civil por danos nucleares

    Energy Technology Data Exchange (ETDEWEB)

    Menendez-Moran, E.

    2011-07-01

    The entry into force of Law 12/2011 is postponed until the Protocols modifying the Paris and Brussels conventions take effect, since their content complements that of the Conventions. The most significant modifications are the extension of the suppositions of nuclear damage, the geographical scope of application and the time period for claiming personal damages, which is accompanied by higher coverage limits of up to 1,200 million euros. It also includes liability for damages caused by radioactive materials in the custody of the installation owner. (Author)

  5. Compensation for damages in case of a nuclear accident; L'indemnisation des prejudices en cas d'accident nucleaire

    Energy Technology Data Exchange (ETDEWEB)

    Leger, M. [CEA Saclay, 91 - Gif sur Yvette (France)

    2011-01-15

    This article presents the system of compensation for damages in case of a nuclear accident. This system of civil liability for nuclear damage, as a specific regime, departs on several points from the common rules of civil liability, in order to provide an adequate and equitable compensation for the damages suffered by the victims of nuclear accidents. The French system of civil liability for nuclear damage results from two International Conventions integrated in French law (Paris convention 1960 and Brussels convention 1963) and the French law of 1968, October 30 on civil liability in the area of nuclear energy. These texts define the conditions under which a nuclear operator could be held liable in case of a nuclear accident. The protocols to amend the Paris and Brussels Conventions of 2004, not yet come into force, are also presented. They ensure that increased resources are available to compensate a greater number of victims of a nuclear accident. (author)

  6. About the burial of nuclear power plants, damaged or in the process of decommissioning

    International Nuclear Information System (INIS)

    Elbrond, J.

    1994-01-01

    Some underground mining methods leave deep empty holes in the earth's surface behind them. In this paper it is described how to use such mining methods for the burial of damaged nuclear power plants and for the decommissioning by burial of nuclear reactors. The design of a new power plant should be integrated with that of an escapeway - an underground arrangement for burial. The described mining methods are block caving for catastrophy burial, and various stoping methods for planned burial and decommissioning. Blind shaft sinking by full face boring machines for burial and decommissioning of the reactor vessel is also described. All the described activities of mining and shaft sinking are well known. The total costs of burial by these methods are estimated using standard mining industry cost data. These include the costs for normal mine ventilation and groundwater control. However, the estimates of the cost and duration do not include the capital and operational costs of the pre- and post burial activities of ventilation and groundwater control related to the radioactivity. (author)

  7. Probabilistic approaches applied to damage and embrittlement of structural materials in nuclear power plants

    International Nuclear Information System (INIS)

    Vincent, L.

    2012-01-01

    The present study deals with the long-term mechanical behaviour and damage of structural materials in nuclear power plants. An experimental way is first followed to study the thermal fatigue of austenitic stainless steels with a focus on the effects of mean stress and bi-axiality. Furthermore, the measurement of displacement fields by Digital Image Correlation techniques has been successfully used to detect early crack initiation during high cycle fatigue tests. A probabilistic model based on the shielding zones surrounding existing cracks is proposed to describe the development of crack networks. A more numeric way is then followed to study the embrittlement consequences of the irradiation hardening of the bainitic steel constitutive of nuclear pressure vessels. A crystalline plasticity law, developed in agreement with lower scale results (Dislocation Dynamics), is introduced in a Finite Element code in order to run simulations on aggregates and obtain the distributions of the maximum principal stress inside a Representative Volume Element. These distributions are then used to improve the classical Local Approach to Fracture which estimates the probability for a microstructural defect to be loaded up to a critical level. (author) [fr

  8. Acetylation dynamics of human nuclear proteins during the ionizing radiation-induced DNA damage response

    DEFF Research Database (Denmark)

    Bennetzen, Martin; Andersen, J.S.; Lasen, D.H.

    2013-01-01

    Genotoxic insults, such as ionizing radiation (IR), cause DNA damage that evokes a multifaceted cellular DNA damage response (DDR). DNA damage signaling events that control protein activity, subcellular localization, DNA binding, protein-protein interactions, etc. rely heavily on time...

  9. Mycobacterium tuberculosis Ku can bind to nuclear DNA damage and sensitize mammalian cells to bleomycin sulfate.

    Science.gov (United States)

    Castore, Reneau; Hughes, Cameron; Debeaux, Austin; Sun, Jingxin; Zeng, Cailing; Wang, Shih-Ya; Tatchell, Kelly; Shi, Runhua; Lee, Kyung-Jong; Chen, David J; Harrison, Lynn

    2011-11-01

    Radiotherapy and chemotherapy are effective cancer treatments due to their ability to generate DNA damage. The major lethal lesion is the DNA double-strand break (DSB). Human cells predominantly repair DSBs by non-homologous end joining (NHEJ), which requires Ku70, Ku80, DNA-PKcs, DNA ligase IV and accessory proteins. Repair is initiated by the binding of the Ku heterodimer at the ends of the DSB and this recruits DNA-PKcs, which initiates damage signaling and functions in repair. NHEJ also exists in certain types of bacteria that have dormant phases in their life cycle. The Mycobacterium tuberculosis Ku (Mt-Ku) resembles the DNA-binding domain of human Ku but does not have the N- and C-terminal domains of Ku70/80 that have been implicated in binding mammalian NHEJ repair proteins. The aim of this work was to determine whether Mt-Ku could be used as a tool to bind DSBs in mammalian cells and sensitize cells to DNA damage. We generated a fusion protein (KuEnls) of Mt-Ku, EGFP and a nuclear localization signal that is able to perform bacterial NHEJ and hence bind DSBs. Using transient transfection, we demonstrated that KuEnls is able to bind laser damage in the nucleus of Ku80-deficient cells within 10 sec and remains bound for up to 2 h. The Mt-Ku fusion protein was over-expressed in U2OS cells and this increased the sensitivity of the cells to bleomycin sulfate. Hydrogen peroxide and UV radiation do not predominantly produce DSBs and there was little or no change in sensitivity to these agents. Since in vitro studies were unable to detect binding of Mt-Ku to DNA-PKcs or human Ku70/80, this work suggests that KuEnls sensitizes cells by binding DSBs, preventing human NHEJ. This study indicates that blocking or decreasing the binding of human Ku to DSBs could be a method for enhancing existing cancer treatments.

  10. Nuclear medicine in the detection of radiation associated normal tissue damage of kidney, brain and salivary glands

    International Nuclear Information System (INIS)

    Liu Xiaomei; Li Dongxue; Pan Liping

    2005-01-01

    The radiation induced damage of kidney, brain and salivary glands is an important complicating disease after limit radiotherapy. The routine technology of nuclear medicine, such as tracing and imaging technique conduce to dose-effect calculations used in the planning of modern radiotherapy to three major organ systems and early detection of irradiation induced organ dysfunctions, as well as increased availability of radiotherapy. (authors)

  11. Optional Protocol concerning the compulsory settlement of disputes to the Vienna Convention on civil liability for nuclear damage

    International Nuclear Information System (INIS)

    1999-01-01

    The document reproduces the text of the Optional Protocol Concerning the Compulsory Settlement of Disputes to the Vienna Convention on Civil Liability for Nuclear Damage which was adopted on 21 May 1963 by the International Conference held in Vienna from 29 April to 19 May 1963. It came into force on 13 May 1999

  12. TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs

    Science.gov (United States)

    Huang, Shar-yin N.; Murai, Junko; Dalla Rosa, Ilaria; Dexheimer, Thomas S.; Naumova, Alena; Gmeiner, William H.; Pommier, Yves

    2013-01-01

    Chain-terminating nucleoside analogs (CTNAs) that cause stalling or premature termination of DNA replication forks are widely used as anticancer and antiviral drugs. However, it is not well understood how cells repair the DNA damage induced by these drugs. Here, we reveal the importance of tyrosyl–DNA phosphodiesterase 1 (TDP1) in the repair of nuclear and mitochondrial DNA damage induced by CTNAs. On investigating the effects of four CTNAs—acyclovir (ACV), cytarabine (Ara-C), zidovudine (AZT) and zalcitabine (ddC)—we show that TDP1 is capable of removing the covalently linked corresponding CTNAs from DNA 3′-ends. We also show that Tdp1−/− cells are hypersensitive and accumulate more DNA damage when treated with ACV and Ara-C, implicating TDP1 in repairing CTNA-induced DNA damage. As AZT and ddC are known to cause mitochondrial dysfunction, we examined whether TDP1 repairs the mitochondrial DNA damage they induced. We find that AZT and ddC treatment leads to greater depletion of mitochondrial DNA in Tdp1−/− cells. Thus, TDP1 seems to be critical for repairing nuclear and mitochondrial DNA damage caused by CTNAs. PMID:23775789

  13. Lightweight Damage Tolerant, High-Temperature Radiators for Nuclear Power and Propulsion

    Science.gov (United States)

    Craven, Paul D.; SanSoucie, Michael P.

    2015-01-01

    NASA is increasingly emphasizing exploration to bodies beyond near-Earth orbit. New propulsion systems and new spacecraft are being built for these missions. As the target bodies get further out from Earth, high energy density systems, e.g., nuclear fusion, for propulsion and power will be advantageous. The mass and size of these systems, including supporting systems such as the heat exchange system, including thermal radiators, will need to be as small as possible. Conventional heat exchange systems are a significant portion of the total thermal management mass and size. Nuclear electric propulsion (NEP) is a promising option for high-speed, in-space travel due to the high energy density of nuclear fission power sources and efficient electric thrusters. Heat from the reactor is converted to power for use in propulsion or for system power. The heat not used in the power conversion is then radiated to space as shown in figure 1. Advanced power conversion technologies will require high operating temperatures and would benefit from lightweight radiator materials. Radiator performance dictates power output for nuclear electric propulsion systems. Pitch-based carbon fiber materials have the potential to offer significant improvements in operating temperature, thermal conductivity, and mass. These properties combine to allow significant decreases in the total mass of the radiators and significant increases in the operating temperature of the fins. A Center-funded project at NASA Marshall Space Flight Center has shown that high thermal conductivity, woven carbon fiber fins with no matrix material, can be used to dissipate waste heat from NEP systems and because of high specific power (kW/kg), will require less mass and possibly less total area than standard metal and composite radiator fins for radiating the same amount of heat. This project uses an innovative approach to reduce the mass and size required for the thermal radiators to the point that in-space NEP and power

  14. Damage Curves of a Nuclear Reactor Structure exposed to Air Blast Loading

    International Nuclear Information System (INIS)

    Brandys, I.; Ornai, D.; Ronen, Y.

    2014-01-01

    Nuclear Power Plant (NPP) radiological hazards due to accidental failure or deliberated attacks are of most concern due to their destructive and global consequences: large area contaminations, injuries, exposure to ionizing radiation (which can cause death or illness, depends on the levels of exposure), loss of lives of both humans and animals, and severe damage to the environment. Prevention of such consequences is of a global importance and it has led to the definition of safety & design guidelines, and regulations by various authorities such as IAEA, U.S. NRC, etc. The guidelines define general requirements for the integrity of a NPP’s physical barriers (such as protective walls) when challenged by external events, for example human induced explosion. A more specific relation to the design of a NPP is that its structures and equipment (reactor building, fuel building, safeguards building, diesel-generator building, pumping station, nuclear auxiliaries building, and effluent treatment building) must function properly: shutdown the reactor, removal of decayed heat, storage of spent fuel, and treatment and containment of radioactive effluents) under external explosion. It requires that the NPP’s structures and equipment resistance to external explosion should be analyzed and verified. The air blast loading created by external explosion, as well as its effects & consequences on different kinds of structures are described in the literature. Structural elements response to the air blast can be analyzed in general by a Single Degree of Freedom (SDOF) system that converts a distributed mass, loads, and resistance to concentrated mass, force, and stiffness located at a representative point of the structure's element where the displacements are the highest one. Proper shielding should be designed if the explosion blast effects are greater than the resistance capacity.External explosion effects should be considered within the Screening Distance Value (SDV) of the NPP

  15. Radiation damage study in montmorillonites. Application to the high-level nuclear waste disposal in France

    International Nuclear Information System (INIS)

    Sorieul, St.

    2003-11-01

    Smectite is a major component of bentonite, a material considered for engineered barriers in high level nuclear wastes repositories (HLNWR). In order to predict the long-term performance of the bentonite, various physical and chemical factors such as, e.g., thermal gradient, redox potential or mechanical stresses are currently considered. By contrast, little is known about radiation effects in smectite, although it might affect the properties of this mineral through cumulative radiation damages produced by ionizing radiations. The present study focuses on radiation damage in montmorillonite considered herein as a simplified model of bentonite. Two reference clays have been selected, one from Liaoning (China, CHI), containing native radiation-induced defects, and the other (called MX) separated from the MX80 reference bentonite (Wyoming, USA). They are distinguished by layer composition, particularly iron content (1 % and 4 % for CHI and MX, respectively). Radiation effects have been studied by combining X-ray diffraction, Fourier transform infrared spectroscopy, Electron Paramagnetic Resonance (EPR) and Moessbauer spectroscopies. Ionizing irradiation induces two main effects. First, several paramagnetic point defects are identified as trapped holes located on oxygen atoms of the smectite structure. These defects are characterized by different thermal stabilities, according to annealing experiments. Their creation is limited by saturation curve with maximum damage around 100 MGy. The response of the two montmorillonites is different in terms of nature and production of point defects, indicating a role of layer composition and structural precursors. Besides, EPR and Moessbauer results show substantial modifications of the oxidation state of structural iron, which are sample and dose-dependent. Irradiation induces reduction and oxidation of iron in CHI and MX samples, respectively. Moreover, physico-chemical treatments show that intensity of redox effects varies

  16. Stochastic evaluation of the dynamic response and the cumulative damage of nuclear power plant piping

    International Nuclear Information System (INIS)

    Suzuki, Kohei; Aoki, Shigeru; Hanaoka, Masaaki

    1981-01-01

    This report deals with a fundamental study concerning an evaluation of uncertainties of the nuclear piping response and cumulative damage under excess-earthquake loadings. The main purposes of this study cover following several problems. (1) Experimental estimation analysis of the uncertainties concerning the dynamic response and the cumulative failure by using piping test model. (2) Numerical simulation analysis by Monte Carlo method under the assumption that relation between restoring force and deformation is characterized by perfectly elasto-plastic one. (Checking the mathematical model.) (3) Development of the conventional uncertainty estimating method by introducing a perturbation technique based on an appropriate equivalently linearized approach. (Checking the estimation technique.) (4) An application of this method to more realistical cases. Through above mentioned procedures some important results are obtained as follows; First, fundamental statistical properties of the natural frequencies and the number of cycle to failure crack initiation are evaluated. Second, the effect of the frequency fluctuation and the yielding fluctuation are estimated and examined through Monte Carlo simulation technique. It has become clear that the yielding fluctuation gives significant effect on the piping power response up to its failure initiation. Finally some results through proposed perturbation technique are discussed. Statistical properties estimated coincide fairly well with those through numerical simulation. (author)

  17. Long-term prediction of corrosion damage in nuclear waste systems

    International Nuclear Information System (INIS)

    Hidekazu Asano; Feron, Damien; Gens, Robert; Padovani, Cristiano; Naoki Taniguchi

    2014-01-01

    Complete text of publication follows: The Fifth International Workshop on Long-Term Prediction of Corrosion Damage in Nuclear Waste Systems was held at the Taisetsu Crystal Hall in Asahikawa, Hokkaido, Japan from October 6 to 10, 2013, following the four previous successful workshops (Cadarache, France, 2001; Nice, France, 2004; Pennsylvania State University, USA, 2007 and Bruges, Belgium, 2010). It was organised by the Japan Society of Corrosion Engineering (JSCE) and supported by the European Federation of Corrosion (EFC): Nuclear Corrosion Working Party (WP4) as of EFC event No.360. Furthermore, it was supported by the Division of Nuclear Fuel Cycle and Environment (NUCE) of the Atomic Energy Society of Japan (AESJ) and The Japan Society of Mechanical Engineers (JSME). Twenty nine (29) oral presentations were distributed among eleven (11) sessions covering a broad range of subjects. Another twenty eight (28) studies were presented at a poster session. A total of sixty seven (67) participants from twelve (12) countries attended the event. The presentations and the following discussion provided contextual information about the state of some national programmes and covered in detail a range of experimental and modelling studies aimed at evaluating the corrosion behaviour of a range of candidate materials and designs for the storage and disposal of radioactive wastes considered across the globe. These included modelling studies aimed at evaluating the durability of container designs for high level waste (HLW), spent nuclear fuel (SNF) and intermediate level waste (ILW), experimental studies of the corrosion behaviour of copper, carbon steel, and stainless steel in conditions relevant to storage (atmospheric) or disposal (near neutral or alkaline), as well as studies of archaeological artifacts and natural analogues aimed at supporting long-term predictions. Specific sessions were dedicated to microbial induced corrosion (MIC) and to the corrosion properties of

  18. A role for nuclear translocation of tripeptidyl-peptidase II in reactive oxygen species-dependent DNA damage responses

    Energy Technology Data Exchange (ETDEWEB)

    Preta, Giulio; Klark, Rainier de [Center for Molecular Medicine (CMM), Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm (Sweden); Glas, Rickard, E-mail: rickard.glas@ki.se [Center for Molecular Medicine (CMM), Department of Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm (Sweden)

    2009-11-27

    Responses to DNA damage are influenced by cellular metabolism through the continuous production of reactive oxygen species (ROS), of which most are by-products of mitochondrial respiration. ROS have a strong influence on signaling pathways during responses to DNA damage, by relatively unclear mechanisms. Previous reports have shown conflicting data on a possible role for tripeptidyl-peptidase II (TPPII), a large cytosolic peptidase, within the DNA damage response. Here we show that TPPII translocated into the nucleus in a p160-ROCK-dependent fashion in response to {gamma}-irradiation, and that nuclear expression of TPPII was present in most {gamma}-irradiated transformed cell lines. We used a panel of nine cell lines of diverse tissue origin, including four lymphoma cell lines (T, B and Hodgkins lymphoma), a melanoma, a sarcoma, a colon and two breast carcinomas, where seven out of nine cell lines showed nuclear TPPII expression after {gamma}-irradiation. Further, this required cellular production of ROS; treatment with either N-acetyl-Cysteine (anti-oxidant) or Rotenone (inhibitor of mitochondrial respiration) inhibited nuclear accumulation of TPPII. The local density of cells was important for nuclear accumulation of TPPII at early time-points following {gamma}-irradiation (at 1-4 h), indicating a bystander effect. Further, we showed that the peptide-based inhibitor Z-Gly-Leu-Ala-OH, but not its analogue Z-Gly-(D)-Leu-Ala-OH, excluded TPPII from the nucleus. This correlated with reduced nuclear expression of p53 as well as caspase-3 and -9 activation in {gamma}-irradiated lymphoma cells. Our data suggest a role for TPPII in ROS-dependent DNA damage responses, through alteration of its localization from the cytosol into the nucleus.

  19. Harmonization of the Romanian legislation in the field of civil liability for nuclear damages with the international legislation in the field

    International Nuclear Information System (INIS)

    Chiripus, Vlad

    2005-01-01

    The paper is an overview of the Romanian legal provisions in the filed of civil liability for nuclear damages in the last three decades introducing the concept and the evolution of its legal regime towards a total harmonization with the European legislation. Its modernity even from (and in spite of) its communist beginnings in 1947 (Law no. 61 regarding the deployment of nuclear activities in the Romanian Socialist Republic) is emphasized. It focuses on the key laws - Law no. 703/2001 on civil liability for nuclear damages, and Government Decision no. 894/2003 for the approval of the Norms for enforcement of Law no. 703/2001- that currently define the Romanian regime for civil liability for nuclear damages. This encompasses the relevant responsibilities of nuclear operators, the Romanian nuclear damage compensation system, statute of limitation for claims, types of insurance and financial guarantees. These refer civil liability for nuclear damages, limits of nuclear operators' liability, specific requirements regarding the insurance, responsibilities of control and supervision bodies, assessment of nuclear damage. This makes Romania - in terms of legislation - one of the most advanced countries in the field. (author)

  20. Nuclear magnetic resonance analysis of freeze-thaw damage in natural pumice concrete

    Directory of Open Access Journals (Sweden)

    Wang, Xiaoxiao

    2016-06-01

    Full Text Available This paper presents an analysis of the damage propagation features of the pore structure of natural pumice lightweight aggregate concrete (LWC under freeze-thaw cyclic action. After freeze-thaw cycling, we conducted nuclear magnetic resonance (NMR tests on the concrete and acquired the porosity, distribution of transverse relaxation time T2, and magnetic resonance imaging (MRI results. The results showed the following. The T2 distribution of the LWC prior to freeze-thaw cycling presented four peaks representative of a preponderance of small pores. After 50, 100, 150, and 200 freeze-thaw cycles, the total area of the T2 spectrum and the porosity increased significantly. The MRI presented the changing spatial distribution of pores within the LWC during freeze-thaw cycling. Ultrasonic testing technology was applied simultaneously to analyze the NMR results, which verified that the new NMR technology demonstrated high accuracy and practicability for research regarding freeze-thaw concrete damage.En este trabajo se analiza la propagación de los daños que se producen en la estructura porosa de hormigón aligerado a base de piedra pómez natural sometido a la acción cíclica de hielo-deshielo. Después de realizarse los ensayos de hielo-deshielo, el hormigón se analizó mediante resonancia magnética nuclear (RMN, determinándose la porosidad y la distribución del tiempo de relajación transversal, T2, y registrándose las imágenes captadas por resonancia magnética. De acuerdo con los resultados obtenidos, antes de los ciclos de hielo-deshielo la distribución de T2 del hormigón aligerado presentaba cuatro picos, indicativos de un predominio de poros pequeños. Después de que se sometiera a 50, 100, 150, y 200 ciclos, se observó un aumento importante tanto de la porosidad como de la superficie total del espectro de T2. Las imágenes captadas por resonancia magnética evidenciaron la modificación de la distribución espacial de los poros del

  1. Metallographic examination of damaged N reactor spent nuclear fuel element SFEC5,4378

    Energy Technology Data Exchange (ETDEWEB)

    Marschman, S.C.; Pyecha, T.D.; Abrefah, J.

    1997-08-01

    N-Reactor spent nuclear fuel (SNF) is currently residing underwater in the K Basins at the Hanford site, in Richland, Washington. This report presents results of the metallographic examination of specimens cut from an SNF element (Mark IV-E) with breached cladding. The element had resided in the K-West (KW) Storage Basin for at least 10 years after it was discharged from the N-Reactor. The storage containers in the KW Basin were nominally closed, isolating the SNF elements from the open pool environment. Seven specimens from this Mark IV-E outer fuel element were examined using an optical metallograph. Included were two specimens that had been subjected to a conditioning process recommended by the Independent Technical Assessment Team, two specimens that had been subjected to a conditioning process recommended in the Integrated Process Strategy Report, and three that were in the as-received, as-cut condition. One of the as-received specimens had been cut from the damaged (or breached) end of the element. All other specimens were cut from the undamaged mid-region of the fuel element. The specimens were visually examined to (1) identify uranium hydride inclusions present in the uranium metal fuel, (2) measure the thickness of the oxide layer formed on the uranium edges and assess the apparent integrity and adhesion of the oxide layer, and (3) look for features in the microstructure that might provide an insight into the various corrosion processes that occurred during underwater storage in the KW Basin. These features included, but were not limited to, the integrity of the cladding and the fuel-to-cladding bond, obvious anomalies in the microstructure, excessive pitting or friability of the fuel matrix, and obvious anomalies in the distribution of uranium hydride or uranium carbide inclusions. Also, the observed metallographic features of the conditioned specimens were compared with those of the as-received (unconditioned) specimens. 11 refs., 93 figs., 2 tabs.

  2. The alkaline comet assay as a biomarker of primary DNA damage in peripheral blood leukocytes of nuclear medicine personnel

    International Nuclear Information System (INIS)

    Kopjar, N.; Garaj-Vrhovac, V.

    2003-01-01

    The aim of this study was to assess whether occupational exposure to chronic low doses of ionizing radiation in nuclear medicine departments may lead to genotoxicity. The alkaline comet assay was selected as a bio-marker of exposure to evaluate the levels of primary DNA damage in peripheral blood leukocytes of exposed and corresponding control subjects. Statistically significant differences were found between comet tail length and tail moment values measured in leukocytes from the exposed and control groups. Within exposed group significant inter-individual differences in DNA damage were assessed, indicating different genome sensitivity. In majority of exposed subjects the levels of DNA damage were in positive correlation with the duration of occupational exposure, while the influences of age and dosimeter readings could be excluded. However, the levels of primary DNA damage detected both in control and exposed subjects were significantly influenced by smoking. The present study indicates the possibility of genotoxic risks related to occupational exposure in nuclear medicine departments. Therefore, the exposed personnel should carefully apply the radiation protection procedures to minimize, as low as possible, radiation exposure to avoid possible genotoxic effects. According to results obtained, the alkaline comet assay could be usefully applied as a sensitive additional bio-marker in the regular health screening of workers occupationally exposed to low doses of ionizing radiation. (authors)

  3. 75 FR 43945 - Convention on Supplementary Compensation for Nuclear Damage Contingent Cost Allocation

    Science.gov (United States)

    2010-07-27

    ... of nuclear power around the world to meet the challenges of climate change, energy security, and... than power reactors having a thermal power rating of over 300 Megawatts. Also, nuclear facilities other... United States nuclear reactor operators. 934(a)(1). \\3\\ The Price-Anderson Act (``Price-Anderson'' or...

  4. Co-visualization of DNA damage and ion traversals in live mammalian cells using a fluorescent nuclear track detector

    International Nuclear Information System (INIS)

    Kodaira, Satoshi; Konishi, Teruaki; Kobayashi, Alisa

    2015-01-01

    The geometric locations of ion traversals in mammalian cells constitute important information in the study of heavy ion-induced biological effect. Single ion traversal through a cellular nucleus produces complex and massive DNA damage at a nanometer level, leading to cell inactivation, mutations and transformation. We present a novel approach that uses a fluorescent nuclear track detector (FNTD) for the simultaneous detection of the geometrical images of ion traversals and DNA damage in single cells using confocal microscopy. HT1080 or HT1080–53BP1-GFP cells were cultured on the surface of a FNTD and exposed to 5.1-MeV/n neon ions. The positions of the ion traversals were obtained as fluorescent images of a FNTD. Localized DNA damage in cells was identified as fluorescent spots of γ-H2AX or 53BP1-GFP. These track images and images of damaged DNA were obtained in a short time using a confocal laser scanning microscope. The geometrical distribution of DNA damage indicated by fluorescent γ-H2AX spots in fixed cells or fluorescent 53BP1-GFP spots in living cells was found to correlate well with the distribution of the ion traversals. This method will be useful for evaluating the number of ion hits on individual cells, not only for micro-beam but also for random-beam experiments. (author)

  5. Scoping of material damage with FISPACT-II and different nuclear data libraries: transmutation, activation, and PKAs

    International Nuclear Information System (INIS)

    Gilbert, M.R.; Sublet, J.-Ch.

    2016-01-01

    The uncertainty associated with nuclear data, and the simulated predictions of transmutation, activation, and primary damage events derived from them, is not only that derived based on the quantified errors in a particular nuclear library. Uncertainty also manifests in comparisons between different libraries – if they do not produce the same results, then, since it often impossible to know a priori which library is best, predicted results must be considered to have an uncertainty (at least) as much as the variation between libraries. Of course, this situation is further complicated by the fact that it is not always possible, or practical, to produce results with multi-libraries. There is thus a need, within the nuclear data community, to assess different libraries, and make recommendations about the best choice of library for particular applications, in this case material science

  6. IAEA advisory group meeting on nuclear data for radiation damage assessment and related safety aspects, Vienna, 12-16 October 1981

    International Nuclear Information System (INIS)

    Kocherov, N.

    1982-01-01

    This Advisory Group Meeting on Nuclear Data for Radiation Damage Assessment and Related Safety Aspects was convened by the IAEA Nuclear Data Section, at IAEA Headquarters in Vienna, Austria, from 12-16 October 1981. The meeting was attended by 34 participants from 15 countries and 2 international organizations. The main objective of the meeting was to review the requirements for and the status of nuclear data needed for radiation damage estimates in reactor structural materials and related reactor safety aspects, and to develop recommendations to the Nuclear Data Section of the IAEA for its future activities in this field. (author)

  7. The Chernobyl case: its repercussions on the International System on Civil Liability for Nuclear Damages

    International Nuclear Information System (INIS)

    Gonzalez Guadarrama, J.L.

    1992-01-01

    With the discovery of the Nuclear Energy the world has been development her life the present investigation is based in the accident of the one of the most important Nuclear Power Plant in the world, situated in the Union of Socialist Sovietic Republics. The Nuclear Power Plant of Chernobyl. Us found in the investigation what not exist one legislation agree with the needs of development of the actual world in matter of the liability civil in case of the nuclear accidents. Found only the Convention of the Vienna. the Convention of the Brussels the which only cover the transportation the Nuclear substances in ships and others transportation medios. The complementary a the convention of the Paris and actually The Communication in case of the nuclear accidents and radiological accidents. In the present work think what the Community International haven the needs of created one legislation with character international what can help a the many countries what have Nuclear Power Plants, on all for protection of the her habitants. The International Atomic Energy Agency together with the International Justice Court and the United Nations Organization (U.N.O.) aplicated the law in matter of the nuclear accidents derivates of the liability responsibility in the use of the Nuclear Plants for elaboration the Electrical Energy or for Investigation in matter the nuclear energy both with identical responsibility civil in case the nuclear accident. (Author)

  8. Damage of the Unit 1 reactor building overhead bridge crane at Onagawa Nuclear Power Station caused by the Great East Japan Earthquake and its repair works

    International Nuclear Information System (INIS)

    Sugamata, Norihiko

    2014-01-01

    The driving shaft bearings of the Unit 1 overhead bridge crane were damaged by the Great East Japan Earthquake at Onagawa Nuclear Power Station. The situation, investigation and repair works of the bearing failure are introduced in this paper. (author)

  9. Vienna convention on civil liability for nuclear damage. Signatures, ratifications, accessions and successions and text of reservations/declarations. Status as of 31 December 1996

    International Nuclear Information System (INIS)

    1997-01-01

    The document refers to the Vienna Convention on Civil Liability for Nuclear Damage (IAEA-INFCIRC-500), giving the status of signatures, ratifications, accessions and successions, and the texts of reservations/declarations as of 31 December 1996

  10. Vienna convention on civil liability for nuclear damage. Signatures, ratifications, accessions and successions and text of reservations/declarations. Status as of 31 December 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-02-28

    The document refers to the Vienna Convention on Civil Liability for Nuclear Damage (IAEA-INFCIRC-500), giving the status of signatures, ratifications, accessions and successions, and the texts of reservations/declarations as of 31 December 1996.

  11. Evaluation of nuclear power plant component failure probability and core damage probability using simplified PSA model

    International Nuclear Information System (INIS)

    Shimada, Yoshio

    2000-01-01

    It is anticipated that the change of frequency of surveillance tests, preventive maintenance or parts replacement of safety related components may cause the change of component failure probability and result in the change of core damage probability. It is also anticipated that the change is different depending on the initiating event frequency or the component types. This study assessed the change of core damage probability using simplified PSA model capable of calculating core damage probability in a short time period, which is developed by the US NRC to process accident sequence precursors, when various component's failure probability is changed between 0 and 1, or Japanese or American initiating event frequency data are used. As a result of the analysis, (1) It was clarified that frequency of surveillance test, preventive maintenance or parts replacement of motor driven pumps (high pressure injection pumps, residual heat removal pumps, auxiliary feedwater pumps) should be carefully changed, since the core damage probability's change is large, when the base failure probability changes toward increasing direction. (2) Core damage probability change is insensitive to surveillance test frequency change, since the core damage probability change is small, when motor operated valves and turbine driven auxiliary feed water pump failure probability changes around one figure. (3) Core damage probability change is small, when Japanese failure probability data are applied to emergency diesel generator, even if failure probability changes one figure from the base value. On the other hand, when American failure probability data is applied, core damage probability increase is large, even if failure probability changes toward increasing direction. Therefore, when Japanese failure probability data is applied, core damage probability change is insensitive to surveillance tests frequency change etc. (author)

  12. Damage-Tolerant, Lightweight, High-Temperature Radiator for Nuclear Powered Spacecraft

    Data.gov (United States)

    National Aeronautics and Space Administration — Game-changing propulsion systems are often enabled by novel designs using advanced materials. Radiator performance dictates power output for nuclear electric...

  13. Necessity of radiation education suggested from press report during earthquake damage of Kashiwazaki-Kariwa Nuclear Power Station

    International Nuclear Information System (INIS)

    Hamamoto, Kazuko; Narabayashi, Tadashi; Itami, Toshio; Kobayashi, Masahide; Akizuki, Teruo; Onishi, Hidetoshi

    2009-01-01

    Although Kashiwazaki-Kariwa Nuclear Power Station was affected by Chuetsu-Oki earthquake, the important components in the reactor building were hardly damaged, and fundamental nuclear safety was ensured. However, as the mass communication media reported the pictures of the black smoke of fire accident of the transformer, sloshing of the pool, etc. without declaration of 'Safety' by the Central Government or sufficient explanation, the habitants on the site and the Japan's people were put into anxiety and thus, harmful rumor was spread. The people obtain the information from the mass communication media, and they believed all the reports of the mass media. Behind it, there is a fundamental knowledge among them that Radiation = 'dangerous', 'bad for health' and 'awful' = Nuclear Power Generation. This knowledge has been fixed more firmly due to the report of the earthquake damage. In order to escape from this deep-rooted scheme, it is necessary to spread the correct knowledge on the radiation. At this time, the Official Curriculum Guidelines for Junior High School are revised, and the radiation education is started for the first time in 30 years. We analyzed and evaluated the results of the survey performed by Radiation Education Forum, and, simultaneously, we considered the necessity of the radiation education judging from the reports of the mass communication media. (author)

  14. Applications of seismic damage hazard analysis for the qualification of existing nuclear and offshore facilities

    International Nuclear Information System (INIS)

    Bazzurro, P.; Manfredini, G.M.; Diaz Molina, I.

    1995-01-01

    The Seismic Damage Hazard Analysis (SDHA) is a methodology which couples conventional Seismic Hazard Analysis (SHA) and non-linear response analysis to seismic loadings. This is a powerful tool in the retrofit process: SDHA permits the direct computation of the probability of occurrence of damage and, eventually, collapse of existing and upgraded structural systems. The SDHA methodology is a significant step towards a better understanding and quantification of structural seismic risk. SDHA incorporates and explicitly accounts for seismic load variability, seismic damage potential variability and structural resistance uncertainty. In addition, SDHA makes available a sound strategy to perform non-linear dynamic analyses. A limited number of non-linear dynamic analyses is sufficient to obtain estimates of damage and its probability of occurrence. The basic concepts of the SDHA methodology are briefly reviewed. Illustrative examples are presented, regarding a power house structure, a tubular structure and seabed slope stability problem. (author)

  15. Account of the effect of nuclear collision cascades in model of radiation damage of RPV steels

    International Nuclear Information System (INIS)

    Kevorkyan, Yu.R.; Nikolaev, Yu.A.

    1997-01-01

    A kinetic model is proposed for describing the effect of collision cascades in model of radiation damage of reactor pressure vessel steels. This is a closed system of equations which can be solved only by numerical methods in general case

  16. Indemnification of damage to the environment caused by non-nuclear industrial activities

    International Nuclear Information System (INIS)

    Smets, H.

    1985-01-01

    Environmental damage has reached catastrophic proportions, implying the death of hundreds of people or expenses of many hundreds of million dollars. The financial impact of this damage is however small at the level of the industrial sector concerned which could bear its costs. If States would take measures to redistribute such costs, they would avoid having to compensate victims of the gravest accidents. Special procedures were introduced for this purpose in certain industrial sectors. (NEA) [fr

  17. The order for enforcing the law on indemnity agreement for compensation of nuclear damage

    International Nuclear Information System (INIS)

    1987-01-01

    This report shows the Cabinet Order No.46 of March 6, 1962. The Order consists of eleven Articles. The provisions under Article 1 and Article 2 specify requirements for conforming to the Law concerning Contract for Compensation and Indemnity for Nuclear Energy Loss. The provisions under Article 3 provide for the compensation premium rate (5/10,000). Data to be reported to the government are given under Article 4. Such data include purpose, type and thermal output of the reactor; location and structure of the nuclear reactor facilities; arrangements in the nuclear reactor facilities; plan for operation of the nuclear reactor; type and yearly amount of nuclear fuel substances used; method for disposal of spent fuel; matters concerning contract for liability insurance; location, structure, etc. of processing facilities, reprocessing facilities and waste disposal facilities; route and method for transporting materials contaminated with nuclear source materials or nuclear fuel substances; etc. Managers of nuclear energy business should pay the security money every year, which goes to the national treasury. (Nogami, K.)

  18. Federal Act of 29 April 1964 on Liability for Nuclear Damage (Atomic Liability Act)

    International Nuclear Information System (INIS)

    Under this Act, the operator of a nuclear installation is liable for any nuclear incident occurring in such installation or which is caused by nuclear substances in his charge. If an incident is caused by a radioisotope, the person in possession of the radioisotope at the time of the incident is liable therefore. When an incident occurs during transport of nuclear substances, the carrier is liable in three cases only: when such substances are neither despatched to nor originating from installations on Austrian territory; when they are despatched without the written consent of the Austrian operator who is to receive them; and when they are not destined for a nuclear installation. Other provisions of the Act fix liability ceilings, a basis for apportionment of compensation when several victims are involved and the amount of security for coverage of the operators liability. The Act came into force on 1 September 1964. (NEA) [fr

  19. Ion-irradiation-induced damage in nuclear materials: Case study of a-SiO2 and MgO

    International Nuclear Information System (INIS)

    Bachiller-Perea, Diana

    2016-01-01

    One of the most important challenges in Physics today is the development of a clean, sustainable, and efficient energy source that can satisfy the needs of the actual and future society producing the minimum impact on the environment. For this purpose, a huge international research effort is being devoted to the study of new systems of energy production; in particular, Generation IV fission reactors and nuclear fusion reactors are being developed. The materials used in these reactors will be subjected to high levels of radiation, making necessary the study of their behavior under irradiation to achieve a successful development of these new technologies. In this thesis two materials have been studied: amorphous silica (a-SiO 2 ) and magnesium oxide (MgO). Both materials are insulating oxides with applications in the nuclear energy industry. High-energy ion irradiations have been carried out at different accelerator facilities to induce the irradiation damage in these two materials; then, the mechanisms of damage have been characterized using principally Ion Beam Analysis (IBA) techniques. One of the challenges of this thesis was to develop the Ion Beam Induced Luminescence or iono-luminescence (which is not a widely known IBA technique) and to apply it to the study of the mechanisms of irradiation damage in materials, proving the power of this technique. For this purpose, the iono-luminescence of three different types of silica (containing different amounts of OH groups) has been studied in detail and used to describe the creation and evolution of point defects under irradiation. In the case of MgO, the damage produced under 1.2 MeV Au + irradiation has been characterized using Rutherford backscattering spectrometry in channeling configuration and X-ray diffraction. Finally, the iono-luminescence of MgO under different irradiation conditions has also been studied.The results obtained in this thesis help to understand the irradiation-damage processes in materials

  20. Use of classical criterions of a decision making for choice of measures on decrease of economic damage from nuclear and radiation accidents

    International Nuclear Information System (INIS)

    Rylov, M.I.; Kamynov, Sh.V.; Mozhaev, A.S.; Anisimov, N.A.; Nikitin, V.S.

    2004-01-01

    Application of classical criteria of decision making for choice of measures on the decrease of economic damage from possible nuclear and radiation accidents during spent fuel unloading from nuclear submarines and storage in the process of their utilization was demonstrated. Economic damage was chosen as optimization index, three versions of possible accidents and limited number of measures on the decrease of their effect were treated for illustration of the suggested approach. On the base of analysis of classical criteria the optimal strategy for decrease of economic damage was chosen [ru

  1. The nuclear accident of Fukushima Daiichi - Management of contaminated waters from damaged reactors. Situation at the end of June 2103

    International Nuclear Information System (INIS)

    2013-01-01

    This report first describes the water accumulation and continuous flow in buildings of the Fukushima nuclear power station. This water has different origins: some was used to cool the damaged reactors, and some comes from the underground. Waters under buildings must to pumped, processed and stored. The report describes the main objectives of water processing (desalinating and partial removal of radionuclides) and how they are addressed by Tepco. The last part briefly describes how and where Tepco is storing this always increasing volume of processed waters, with of course other water-tightness problems

  2. Act No. 732 of December 7, 1988. Act to amend the Act on civil liability for nuclear damage

    International Nuclear Information System (INIS)

    1988-01-01

    This Act amends Act No. 332 of June 19, 1974 on civil liability for nuclear damage, enabling Denmark to ratify the 1982 Protocols to amend the Paris Convention and the Brussels Supplementary Convention as well as the 1988 Joint Protocol relating to the application of the Vienna and the Paris Convention. The 1988 Act raises the nuclear operator's liability from 75 million DKr to 60 million SDRs while cover involving State funds is raised from 120 million units of account to 300 million SDRs. The Act entered into force on July 1, 1989 except for the provision on State funds which becomes effective when the 1982 Protocol amending the Brussels Convention comes into force. (NEA) [fr

  3. Dark current spectroscopy of space and nuclear environment induced displacement damage defects in pinned photodiode based CMOS image sensors

    International Nuclear Information System (INIS)

    Belloir, Jean-Marc

    2016-01-01

    CMOS image sensors are envisioned for an increasing number of high-end scientific imaging applications such as space imaging or nuclear experiments. Indeed, the performance of high-end CMOS image sensors has dramatically increased in the past years thanks to the unceasing improvements of microelectronics, and these image sensors have substantial advantages over CCDs which make them great candidates to replace CCDs in future space missions. However, in space and nuclear environments, CMOS image sensors must face harsh radiation which can rapidly degrade their electro-optical performances. In particular, the protons, electrons and ions travelling in space or the fusion neutrons from nuclear experiments can displace silicon atoms in the pixels and break the crystalline structure. These displacement damage effects lead to the formation of stable defects and to the introduction of states in the forbidden bandgap of silicon, which can allow the thermal generation of electron-hole pairs. Consequently, non ionizing radiation leads to a permanent increase of the dark current of the pixels and thus a decrease of the image sensor sensitivity and dynamic range. The aim of the present work is to extend the understanding of the effect of displacement damage on the dark current increase of CMOS image sensors. In particular, this work focuses on the shape of the dark current distribution depending on the particle type, energy and fluence but also on the image sensor physical parameters. Thanks to the many conditions tested, an empirical model for the prediction of the dark current distribution induced by displacement damage in nuclear or space environments is experimentally validated and physically justified. Another central part of this work consists in using the dark current spectroscopy technique for the first time on irradiated CMOS image sensors to detect and characterize radiation-induced silicon bulk defects. Many types of defects are detected and two of them are identified

  4. Light ions cyclotron bombardment to simulate fast neutron radiation damage in nuclear materials

    International Nuclear Information System (INIS)

    Segura, E.; Lucki, G.; Aguiar, D.

    1984-01-01

    The applicability and limitations of the use of cyclotron light ions bombardment to simulate the effects of the neutron irradiation are presented. Light ions with energies of about 10 MeV are capable to produce homogeneous damage in specimens suitable for measuring bulk mechanical properties although their low damage rate of 10 -5 dpa.sec -1 limit the dose range to a few dpa. On the other hand, cyclotron alpha particle implantation provides a fast and convenient way of introducing helium with a minimum of side effects so that we can take advantage of this technique to get better understanding of the mechanism by which this insoluble gas produces high temperature embrittlement. Some experimental details such as dimensions and cooling techniques are described. Finally a description of the infrastructure for cyclotron alpha particle implantation and a creep-test facility of the Division of Radiation Damage at IPEN-CNEN/SP are presented. (Author) [pt

  5. Evaluation of fatigue damage in nuclear power plants: evolution and new tools of analysis

    International Nuclear Information System (INIS)

    Cicero, R.; Corchon, F.

    2011-01-01

    This paper presents new fatigue mechanisms requiring analysis, tools developed for evaluation and the latest trends and studies that are currently working in the nuclear field, and allow proper management referring facilities the said degradation mechanism.

  6. Fukushima Daiichi nuclear acccident. Damaged facilities of the site - Situation as on March 2018

    International Nuclear Information System (INIS)

    2018-03-01

    After a recall of the events that led to the Fukushima Daiichi accident, this note presents the situation in March 2018 of the actions of control of the damaged facilities and of their effluents. The last part presents the three steps of the facility control recovery plan retained by TEPCO

  7. Nuclear insulin-like growth factor 1 receptor phosphorylates proliferating cell nuclear antigen and rescues stalled replication forks after DNA damage.

    Science.gov (United States)

    Waraky, Ahmed; Lin, Yingbo; Warsito, Dudi; Haglund, Felix; Aleem, Eiman; Larsson, Olle

    2017-11-03

    We have previously shown that the insulin-like growth factor 1 receptor (IGF-1R) translocates to the cell nucleus, where it binds to enhancer-like regions and increases gene transcription. Further studies have demonstrated that nuclear IGF-1R (nIGF-1R) physically and functionally interacts with some nuclear proteins, i.e. the lymphoid enhancer-binding factor 1 (Lef1), histone H3, and Brahma-related gene-1 proteins. In this study, we identified the proliferating cell nuclear antigen (PCNA) as a nIGF-1R-binding partner. PCNA is a pivotal component of the replication fork machinery and a main regulator of the DNA damage tolerance (DDT) pathway. We found that IGF-1R interacts with and phosphorylates PCNA in human embryonic stem cells and other cell lines. In vitro MS analysis of PCNA co-incubated with the IGF-1R kinase indicated tyrosine residues 60, 133, and 250 in PCNA as IGF-1R targets, and PCNA phosphorylation was followed by mono- and polyubiquitination. Co-immunoprecipitation experiments suggested that these ubiquitination events may be mediated by DDT-dependent E2/E3 ligases ( e.g. RAD18 and SHPRH/HLTF). Absence of IGF-1R or mutation of Tyr-60, Tyr-133, or Tyr-250 in PCNA abrogated its ubiquitination. Unlike in cells expressing IGF-1R, externally induced DNA damage in IGF-1R-negative cells caused G 1 cell cycle arrest and S phase fork stalling. Taken together, our results suggest a role of IGF-1R in DDT. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  8. Civil liability for nuclear damage: selected questions connected with the revision of the Vienna Convention

    International Nuclear Information System (INIS)

    Lopuski, J.

    1993-01-01

    This paper concentrates on certain issues raised by the revision of the Vienna Convention. After a general theoretical review of the risk of and the responsibility for nuclear activities in the existing international civil liability regime, the author analyzes the concept of liability, its extent - whether nuclear liability can be absolute and refers to the possible exonerations - and the channelling of risk and liability in this field. The potential sources of compensation and funds for the operator's liability are also taken into consideration. The author also proposes several solutions taking into account the similar systems already established by other international conventions in force, mainly in the maritime field. 14 refs

  9. Neutron irradiation damage of nuclear graphite studied by high-resolution transmission electron microscopy and Raman spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Krishna, R. [Dalton Cumbrian Facility, Dalton Nuclear Institute, The University of Manchester, Westlakes Science & Technology Park, Moor Row, Whitehaven, Cumbria, CA24 3HA (United Kingdom); Jones, A.N., E-mail: Abbie.Jones@manchester.ac.uk [Nuclear Graphite Research Group, School of MACE, The University of Manchester, Manchester, M13 9PL (United Kingdom); McDermott, L.; Marsden, B.J. [Nuclear Graphite Research Group, School of MACE, The University of Manchester, Manchester, M13 9PL (United Kingdom)

    2015-12-15

    Nuclear graphite components are produced from polycrystalline artificial graphite manufacture from a binder and filler coke with approximately 20% porosity. During the operational lifetime, nuclear graphite moderator components are subjected to fast neutron irradiation which contributes to the change of material and physical properties such as thermal expansion co-efficient, young's modulus and dimensional change. These changes are directly driven by irradiation-induced changes to the crystal structure as reflected through the bulk microstructure. It is therefore of critical importance that these irradiation changes and there implication on component property changes are fully understood. This work examines a range of irradiated graphite samples removed from the British Experimental Pile Zero (BEPO) reactor; a low temperature, low fluence, air-cooled Materials Test Reactor which operated in the UK. Raman spectroscopy and high-resolution transmission electron microscopy (HRTEM) have been employed to characterise the effect of increased irradiation fluence on graphite microstructure and understand low temperature irradiation damage processes. HRTEM confirms the structural damage of the crystal lattice caused by irradiation attributed to a high number of defects generation with the accumulation of dislocation interactions at nano-scale range. Irradiation-induced crystal defects, lattice parameters and crystallite size compared to virgin nuclear graphite are characterised using selected area diffraction (SAD) patterns in TEM and Raman Spectroscopy. The consolidated ‘D’peak in the Raman spectra confirms the formation of in-plane point defects and reflected as disordered regions in the lattice. The reduced intensity and broadened peaks of ‘G’ and ‘D’ in the Raman and HRTEM results confirm the appearance of turbulence and disordering of the basal planes whilst maintaining their coherent layered graphite structure. - Highlights: • Irradiated graphite

  10. Neutron irradiation damage of nuclear graphite studied by high-resolution transmission electron microscopy and Raman spectroscopy

    International Nuclear Information System (INIS)

    Krishna, R.; Jones, A.N.; McDermott, L.; Marsden, B.J.

    2015-01-01

    Nuclear graphite components are produced from polycrystalline artificial graphite manufacture from a binder and filler coke with approximately 20% porosity. During the operational lifetime, nuclear graphite moderator components are subjected to fast neutron irradiation which contributes to the change of material and physical properties such as thermal expansion co-efficient, young's modulus and dimensional change. These changes are directly driven by irradiation-induced changes to the crystal structure as reflected through the bulk microstructure. It is therefore of critical importance that these irradiation changes and there implication on component property changes are fully understood. This work examines a range of irradiated graphite samples removed from the British Experimental Pile Zero (BEPO) reactor; a low temperature, low fluence, air-cooled Materials Test Reactor which operated in the UK. Raman spectroscopy and high-resolution transmission electron microscopy (HRTEM) have been employed to characterise the effect of increased irradiation fluence on graphite microstructure and understand low temperature irradiation damage processes. HRTEM confirms the structural damage of the crystal lattice caused by irradiation attributed to a high number of defects generation with the accumulation of dislocation interactions at nano-scale range. Irradiation-induced crystal defects, lattice parameters and crystallite size compared to virgin nuclear graphite are characterised using selected area diffraction (SAD) patterns in TEM and Raman Spectroscopy. The consolidated ‘D’peak in the Raman spectra confirms the formation of in-plane point defects and reflected as disordered regions in the lattice. The reduced intensity and broadened peaks of ‘G’ and ‘D’ in the Raman and HRTEM results confirm the appearance of turbulence and disordering of the basal planes whilst maintaining their coherent layered graphite structure. - Highlights: • Irradiated graphite exhibits

  11. Analysis of displacement damage in materials in nuclear fusion facilities (DEMO, IFMIF and TechnoFusion)

    International Nuclear Information System (INIS)

    Mota, F.; Vila, R.; Ortiz, C.; Garcia, A.; Casal, N.; Ibarra, A.; Rapisarda, D.; Queral, V.

    2011-01-01

    Present pathway to fusion reactors includes a rigorous material testing program. To reach this objective, irradiation facilities must produce the displacement damage per atom (dpa), primary knock-on atom (PKA) spectrum and gaseous elements by transmutation reactions (He, H) as closely as possible to the ones expected in the future fusion reactors (as DEMO).The irradiation parameters (PKA spectra and damage function) of some candidate materials for fusion reactors (Al 2 O 3 , SiC and Fe) have been studied and then, the suitability of some proposed experimental facilities, such as IFMIF and TechnoFusion, to perform relevant tests with these materials has been assessed.The following method has been applied: neutron fluxes present in different irradiation modules of IFMIF have been calculated by the neutron transport McDeLicious code. In parallel, the energy differential cross sections of PKA have been calculated by using the NJOY code. After that, the damage generated by the PKA spectra was analyzed using the MARLOWE code (binary collision approximation) and custom analysis codes. Finally, to analyze the ions effects in different irradiation conditions in the TechnoFusion irradiation area, the SRIM and Marlowe codes have been used. The results have been compared with the expected ones for a DEMO HCLL reactor.

  12. Analysis of displacement damage in materials in nuclear fusion facilities (DEMO, IFMIF and TechnoFusion)

    Energy Technology Data Exchange (ETDEWEB)

    Mota, F., E-mail: fernando.mota@ciemat.es [Laboratorio Nacional de Fusion por Confinamiento Magnetico-CIEMAT, 28040 Madrid (Spain); Vila, R.; Ortiz, C.; Garcia, A.; Casal, N.; Ibarra, A.; Rapisarda, D.; Queral, V. [Laboratorio Nacional de Fusion por Confinamiento Magnetico-CIEMAT, 28040 Madrid (Spain)

    2011-10-15

    Present pathway to fusion reactors includes a rigorous material testing program. To reach this objective, irradiation facilities must produce the displacement damage per atom (dpa), primary knock-on atom (PKA) spectrum and gaseous elements by transmutation reactions (He, H) as closely as possible to the ones expected in the future fusion reactors (as DEMO).The irradiation parameters (PKA spectra and damage function) of some candidate materials for fusion reactors (Al{sub 2}O{sub 3}, SiC and Fe) have been studied and then, the suitability of some proposed experimental facilities, such as IFMIF and TechnoFusion, to perform relevant tests with these materials has been assessed.The following method has been applied: neutron fluxes present in different irradiation modules of IFMIF have been calculated by the neutron transport McDeLicious code. In parallel, the energy differential cross sections of PKA have been calculated by using the NJOY code. After that, the damage generated by the PKA spectra was analyzed using the MARLOWE code (binary collision approximation) and custom analysis codes. Finally, to analyze the ions effects in different irradiation conditions in the TechnoFusion irradiation area, the SRIM and Marlowe codes have been used. The results have been compared with the expected ones for a DEMO HCLL reactor.

  13. Multifunctional Ebselen drug functions through the activation of DNA damage response and alterations in nuclear proteins.

    Science.gov (United States)

    Azad, Gajendra K; Balkrishna, Shah Jaimin; Sathish, Narayanan; Kumar, Sangit; Tomar, Raghuvir S

    2012-01-15

    Several studies have demonstrated that Ebselen is an anti-inflammatory and anti-oxidative agent. Contrary to this, studies have also shown a high degree of cellular toxicity associated with Ebselen usage, the underlying mechanism of which remains less understood. In this study we have attempted to identify a possible molecular mechanism behind the above by investigating the effects of Ebselen on Saccharomyces cerevisiae. Significant growth arrest was documented in yeast cells exposed to Ebselen similar to that seen in presence of DNA damaging agents (including methyl methane sulfonate [MMS] and hydroxy urea [HU]). Furthermore, mutations in specific lysine residues in the histone H3 tail (H3 K56R) resulted in increased sensitivity of yeast cells to Ebselen presumably due to alterations in post-translational modifications of histone proteins towards regulating replication and DNA damage repair. Our findings suggest that Ebselen functions through activation of DNA damage response, alterations in histone modifications, activation of checkpoint kinase pathway and derepression of ribonucleotide reductases (DNA repair genes) which to the best of our knowledge is being reported for the first time. Interestingly subsequent to Ebselen exposure there were changes in global yeast protein expression and specific histone modifications, identification of which is expected to reveal a fundamental cellular mechanism underlying the action of Ebselen. Taken together these observations will help to redesign Ebselen-based therapy in clinical trials. Copyright © 2011 Elsevier Inc. All rights reserved.

  14. Research status on radiation damage in nuclear materials and recommendations for IAEA activities. Technical report

    International Nuclear Information System (INIS)

    Caro, Alfredo; Caro, Magdalena

    2002-03-01

    This report addresses the synergy between the continuous progress of parallel computing and the spectacular advances in the theoretical framework that describes materials. Together, they contributed to significantly advance our comprehension of materials properties like mechanical behavior. It also highlights its impact on nuclear technology, as it provides physical insight into the complex processes responsible for the degradation of structural materials under neutron irradiation

  15. Fire damage data analysis as related to current testing practices for nuclear power applications

    International Nuclear Information System (INIS)

    Klevan, J.; MacDougall, E.A.; Hall, R.E.

    1978-01-01

    A review of reports of specific fires which have occurred in nuclear power plants in the United States is presented. A limited comparison of cable and similar fires with results of the IEEE 383 fire test used to evaluate cable insulation is also presented

  16. Dual Liability for Nuclear Damage in Conventions and Finnish Legislation in the Field of Transport

    International Nuclear Information System (INIS)

    Manninen, J.

    1986-01-01

    The exception made in the 1960 Paris Convention on Third Party Liability in the Field of Nuclear Energy to the otherwise absolute channelling of liability in order to avoid conflicts with the then existing international agreements in the field of transport is briefly described. The dual liability created by this provision is studied, as well as the question whether and when the victim might prefer to base his claim on a transport agreement instead of the Paris Convention. The so-called nuclear clauses in the new agreements in the transport field are analysed. The problems caused by the absence of a nuclear clause in the Guatemala City and Montreal Protocols, amending the Warsaw Convention relating to international air carriage are noted. Finally the relationship between nuclear liability legislation and transport legislation in Finland, as well as the cases where a dual liability existed at the time of the ratification of the Paris Convention and the changes which have taken place since then are described. (NEA) [fr

  17. Outline of the Guidelines on the Scope of Nuclear Damage. Annex III of Technical Volume 5

    International Nuclear Information System (INIS)

    2015-01-01

    Damage associated with evacuation - Subject areas: evacuation area (restricted area), in-house evacuation area, deliberate evacuation area, evacuation-prepared area in case of emergency, evacuation recommendation spot, and areas for which temporary evacuation was requested by Minamisoma City. – Evacuation, temporary entry, homecoming expenses (evacuation expenses are paid only until evacuee remove to a new residence). – Injury or death (medical treatment expenses, etc., due for instance to a deterioration in the state of health resulting from evacuation and other such actions). – Mental anguish. – Loss or reduction, etc., of property value (including cost of refinement and decontamination in addition to actual loss or reduction of value): – Real estate within Area 3 is estimated to be a total loss. – Real estate value within Areas 1 and 2 is estimated to have decreased from pre-accident prices. – Securing of homes: – For residential houses, compensation for up to 75% of the difference between the original price and the pre-accident price of the house. – For housing land in Area 3, compensation for the difference between the price of newly acquired land and the price of land formerly held. For housing land in Areas 1 and 2, in case where mitigation is allowed as reasonable, compensation of 75% of the difference between the two prices. – For rented houses, compensation for the difference in rent between the new houses and houses standing for the previous eight years. – Business damage (agriculture, forestry and fisheries, general industry, including manufacturing). – Damages due to inability to work. – Examination expenses (human and material)

  18. ASME Section XI philosophy related to operating nuclear plant fatigue damage protection

    International Nuclear Information System (INIS)

    Gosselin, S.R.

    1995-01-01

    When faced with operating fatigue concerns, nuclear plants traditionally look to the requirements contained in the original construction design code, ASME Section 3, as a basis for component operability. These rules constitute the requirements for nuclear power plant vessel and component construction and, when combined with the Owner's Design Specification, provide reasonable assurance of reliable operation. However, once construction is complete and operation begins, the purpose of any subsequent evaluations shifts from component ''design qualification'' to component ''fitness for service.'' This is a role that has been assumed for ASME Section 11. This paper presents a philosophy, recently endorsed by the ASME Section 11 Executive Committee, intended to guide future Code activities regarding fatigue and its impact on component serviceability

  19. Accidents in the operation of nuclear power stations. Action for damages against foreign operators

    International Nuclear Information System (INIS)

    Willner, K.

    1986-01-01

    On the occasion of a lecture evening of the Leo Goodman Library in Munich questions of civil liability of foreign reactor operators in cases of nuclear accidents were discussed by participants of various universities. Special subjects were i.a. problems of civil procedural and insurance law, absolute liability according to sec. 25 Atomic Energy Act as well as questions of applicable law. (WG) [de

  20. Determination of possible damage/degradation of the Sandia National Laboratories Personal Nuclear Accident Dosimeter (PNAD)

    International Nuclear Information System (INIS)

    Potter, Charles Augustus; Ward, Dann C.

    2008-01-01

    This report describes the results of an inspection performed on the existing stock of SNL Personal Nuclear Accident Dosimeters (PNADs). The current stock is approximately 20 years old, and has not been examined since their initial acceptance. A small random sample of PNADs were opened (a destructive process) and the contents visually examined. Sample contents were not degraded and indicate that the existing stock of SNL PNADs is acceptable for continued use

  1. Radioactive impact in South Korea from the damaged nuclear reactors in Fukushima: evidence of long and short range transport

    International Nuclear Information System (INIS)

    Hong, G H; Lee, H M; Kim, S H; Hernández-Ceballos, M A; Lozano, R L; Bolívar, J P; Kim, Y I; Yeh, S-W; Baskaran, M

    2012-01-01

    Traces of long-lived fallout-derived radioisotopes ( 134 Cs and 137 Cs) were found in wet and dry deposition samples collected from the west and east coasts of South Korea from March to May 2011 following the release of radionuclides from the damaged nuclear power plants in Fukushima, Japan. The analysis of air mass back trajectory and atmospheric pressure systems indicated that the Fukushima-derived radiocaesium had predominantly reached South Korea from the west by surface westerlies from 11 March to 5 April; however, after 6 April, air masses arrived from Japan directly due to a high pressure system that developed to the east of Japan. Spatial variation of deposition fluxes of radiocaesium in South Korea was partly attributed to the presence of local longitudinal orography. (paper)

  2. An Experimental Investigation On Minimum Compressive Strength Of Early Age Concrete To Prevent Frost Damage For Nuclear Power Plant Structures In Cold Climates

    International Nuclear Information System (INIS)

    Koh, Kyungtaek; Kim, Dogyeum; Park, Chunjin; Ryu, Gumsung; Park, Jungjun; Lee, Janghwa

    2013-01-01

    Concrete undergoing early frost damage in cold weather will experience significant loss of not only strength, but also of permeability and durability. Accordingly, concrete codes like ACI-306R prescribe a minimum compressive strength and duration of curing to prevent frost damage at an early age and secure the quality of concrete. Such minimum compressive strength and duration of curing are mostly defined based on the strength development of concrete. However, concrete subjected to frost damage at early age may not show a consistent relationship between its strength and durability. Especially, since durability of concrete is of utmost importance in nuclear power plant structures, this relationship should be imperatively clarified. Therefore, this study verifies the feasibility of the minimum compressive strength specified in the codes like ACI-306R by evaluating the strength development and the durability preventing the frost damage of early age concrete for nuclear power plant. The results indicate that the value of 5 MPa specified by the concrete standards like ACI-306R as the minimum compressive strength to prevent the early frost damage is reasonable in terms of the strength development, but seems to be inappropriate in the viewpoint of the resistance to chloride ion penetration and freeze-thaw. Consequently, it is recommended to propose a minimum compressive strength preventing early frost damage in terms of not only the strength development, but also in terms of the durability to secure the quality of concrete for nuclear power plants in cold climates

  3. DART, a BCA code to assess and compare primary irradiation damage in nuclear materials submitted to neutron and ion flux - 02002

    International Nuclear Information System (INIS)

    Luneville, L.; Simeone, D.

    2016-01-01

    When a material is subjected to a flux of high-energy particles, its constituent atoms can be knocked from their equilibrium positions with a wide range of energies, depending on the exact nature of the collision. The spectrum of damage energy, derived from the exact knowledge of the recoil spectra for each nuclear reaction occurring in the solid, constitutes a vital data set required for understanding how materials evolve under irradiation. The knowledge of such damage energy is relevant to compare the impact of different facilities on the structural behavior and relevant properties of materials. The DART code was developed for two distinct reasons: the first one was a correct determination of the Primary Knocked on Atoms (PKA) spectrum from reliable cross section data libraries and the second was a crude estimation of the damage energy induced by different irradiations. This last term can be a quick estimation of radiation damage produced in the same material by different nuclear plants and particle accelerators. Based on the Binary Collision Approximation, this code allows computing the primary spectra produced by neutrons, ions and electrons as well as the damage energy deposited by these particles in a poly atomic material. It is then a tool to compare radiation damage induced in nuclear reactors as well as in ion beam facilities. This brief paper is followed by the slides of the presentation

  4. An Experimental Investigation On Minimum Compressive Strength Of Early Age Concrete To Prevent Frost Damage For Nuclear Power Plant Structures In Cold Climates

    Energy Technology Data Exchange (ETDEWEB)

    Koh, Kyungtaek; Kim, Dogyeum; Park, Chunjin; Ryu, Gumsung; Park, Jungjun; Lee, Janghwa [Korea Institute Construction Technology, Goyang (Korea, Republic of)

    2013-06-15

    Concrete undergoing early frost damage in cold weather will experience significant loss of not only strength, but also of permeability and durability. Accordingly, concrete codes like ACI-306R prescribe a minimum compressive strength and duration of curing to prevent frost damage at an early age and secure the quality of concrete. Such minimum compressive strength and duration of curing are mostly defined based on the strength development of concrete. However, concrete subjected to frost damage at early age may not show a consistent relationship between its strength and durability. Especially, since durability of concrete is of utmost importance in nuclear power plant structures, this relationship should be imperatively clarified. Therefore, this study verifies the feasibility of the minimum compressive strength specified in the codes like ACI-306R by evaluating the strength development and the durability preventing the frost damage of early age concrete for nuclear power plant. The results indicate that the value of 5 MPa specified by the concrete standards like ACI-306R as the minimum compressive strength to prevent the early frost damage is reasonable in terms of the strength development, but seems to be inappropriate in the viewpoint of the resistance to chloride ion penetration and freeze-thaw. Consequently, it is recommended to propose a minimum compressive strength preventing early frost damage in terms of not only the strength development, but also in terms of the durability to secure the quality of concrete for nuclear power plants in cold climates.

  5. Radiation exposure and health damage of residents at Semipalatinsk nuclear test site

    International Nuclear Information System (INIS)

    Tolebay, Rakhypbekov; Noso, Yoshihiro; Takechi, Nobuo

    2016-01-01

    Although the nuclear test site of Semipalatinsk (former Soviet Union and presently the Republic of Kazakhstan) stopped nuclear tests 25 years ago, there are presumably more than 200,000 victims near the site, including persons with a low dose and a high dose. Semey Medical University and Shimane University, together with the Kazakh Scientific Institute for Radiation Medicine and Ecology, have been conducting the measurement of radiation concentration of soil and the thyroid screening of residents. The following were surveyed: (1) chromosomal abnormality for 55 female residents (average 45 years in age) in heavily polluted areas and 25 female residents (average 42 years in age) in non-polluted areas, (2) mental abnormality of residents in polluted areas and non-polluted areas of Semey City, and (3) changes in the frequency of surgery cases for cancer between 1989 and 2014 at Semey Medical University Cancer Center. As for chromosomal abnormality, 3-5 times many mutation cases were observed in heavily polluted areas than in non-polluted areas. The nodules of thyroid gland were four times more frequent in heavily polluted areas. The frequency of a whole variety of cancers was nearly twice in polluted areas compared with in non-polluted areas, most of which were digestive system cancer, lung cancer, and breast cancer in the order. The frequency of mental abnormality has also increased nearly twice as compared to non-polluted areas, and it included neurological disorder, adjustment disorder, neuralgia, moderate depression, and learning disability. These results suggest that some physical effects can be caused by exposure. In the future, this study will investigate the effects of radiation exposure at the nuclear test site. (A.O.)

  6. Concrete Materials with Ultra-High Damage Resistance and Self- Sensing Capacity for Extended Nuclear Fuel Storage Systems

    Energy Technology Data Exchange (ETDEWEB)

    Li, Mo [Univ. of California, Irvine, CA (United States); Nakshatrala, Kalyana [Univ. of Houston, TX (United States); William, Kasper [Univ. of Houston, TX (United States); Xi, Yungping [Univ. of Colorado, Boulder, CO (United States)

    2017-02-08

    The objective of this project is to develop a new class of multifunctional concrete materials (MSCs) for extended spent nuclear fuel (SNF) storage systems, which combine ultra-high damage resistance through strain-hardening behavior with distributed multi-dimensional damage self-sensing capacity. The beauty of multifunctional concrete materials is two-fold: First, it serves as a major material component for the SNF pool, dry cask shielding and foundation pad with greatly improved resistance to cracking, reinforcement corrosion, and other common deterioration mechanisms under service conditions, and prevention from fracture failure under extreme events (e.g. impact, earthquake). This will be achieved by designing multiple levels of protection mechanisms into the material (i.e., ultrahigh ductility that provides thousands of times greater fracture energy than concrete and normal fiber reinforced concrete; intrinsic cracking control, electrochemical properties modification, reduced chemical and radionuclide transport properties, and crack-healing properties). Second, it offers capacity for distributed and direct sensing of cracking, strain, and corrosion wherever the material is located. This will be achieved by establishing the changes in electrical properties due to mechanical and electrochemical stimulus. The project will combine nano-, micro- and composite technologies, computational mechanics, durability characterization, and structural health monitoring methods, to realize new MSCs for very long-term (greater than 120 years) SNF storage systems.

  7. Once again: The inviolability of fundamental rights and the exclusion of damage in connection with the nuclear law

    International Nuclear Information System (INIS)

    Wagner, H.

    1979-01-01

    According to the opinion stated by the author, the Atomic Energy Act and the relevant ordinances are guarenteiing to a sufficient extent the inviolability of fundamental rights, and the courts are effectively safeguarding these rights. The objective standard of value set up by the basic law and on legal system cannot be interpreted to be intended to completely exclude damage, but rather to institute precantions to be taken in order to prevent damage, taking into account the rights and risks involved and considering all of the declared purposes of the Atomic Energy Act, namely not only that of protection from hazards but also that of furtheranice of the paceful use of nuclear energy. In contrast to this, the opponent in the discussion argues that the present Atomic Energy Act is to be interpreted to contain a preventive prohibition reserving the right to grant licenses, and that any activity likely to represent a prejudice to our Basic Law is not in accordance with the constitution. It is the duty of the judiciary, the opponent says, to try to reconcile the requirements of technology and prosperity for the benefit of human life. (HSCH) [de

  8. Loosening and damage mechanism of thread-joined structures in nuclear power equipment

    International Nuclear Information System (INIS)

    Tang Hui

    1999-01-01

    The author proposes a loosening mechanism of thread-joined structures under vibrate environments in the nuclear power equipment and structures, which is on the base of the macro and imperceptible-mechanics analysis. It has answered the problems on the seizing, the adhesive wearing, the generation of cracks, the thread-tooth fracture. So it has a conclusion that the loosening of thread-joined structures is essential trend, in other words, the locking property of thread-pair is failure under vibrate environments

  9. Damage-tolerant design and inspection philosophy for nuclear and other pressure vessels

    International Nuclear Information System (INIS)

    Adams, N.J.I.

    1980-01-01

    Statistical analyses of pressure vessel failure rates indicate that, to date, the record is very good. However, the public hazard and environmental consequences of failure in certain industrial processes now give cause for much greater concern. With the exception of an Appendix in ASME III, the current design codes and requirements for new vessels are all based on the assumption that they are free from cracklike defects, but engineers recognize tht such perfect vessels cannot be manufactured. Taking into account failure mechanisms, material properties, pre- and in-service inspection, proof testing, failure statistics and probabilistic methods, views are put forward on how a damage-tolerant design and inspection philosophy may be developed to reduce further the possibility of ''rogue'' vessel failure. 21 refs

  10. Application of positron annihilation line-shape analysis to fatigue damage for nuclear plant materials

    International Nuclear Information System (INIS)

    Maeda, N.; Uchida, M.; Ohta, Y.; Yoshida, K.

    1996-01-01

    Positron annihilation line-shape analysis is sufficiently sensitive to detect microstructural defects such as vacancies and dislocations. We are developing a portable positron annihilation system and applying this technique to fatigue damage in type 316 stainless steel and SA508 low alloy steel. The positron annihilation technique was found to be sensitive in the early fatigue life, i.e. up to 10% of the fatigue life, but showed little sensitivity in later stages of the fatigue life in type 316 stainless steel and SA508 low alloy steel. Type 316 stainless steel a higher positron annihilation sensitivity than that of SA508. It was considered that the amount of dislocation density change in the stainless steel was greater than that in the low alloy steel, because the initial microstructure contained a low dislocation density because of the solution heat treatment for the type 316 stainless steel. (orig.)

  11. Diffuse vascular damage in a transplanted kidney: an indication for nuclear magnetic resonance?

    Science.gov (United States)

    Burdese, M; Consiglio, V; Mezza, E; Savio, D; Guarena, C; Rossetti, M; Messina, M; Soragna, G; Suriani, C; Rabbia, C; Segoloni, G P; Piccoli, G B

    2005-06-01

    Vascular lesions are an increasing challenge after renal transplantation due to the wider indications for recipients and acceptance criteria for donors. Diagnostic approach and prognostic interpretation are still matter of controversy. The case reported herein may summarize some of the issues in this regard. A 54-year-old woman, on renal replacement therapy since 1974, and a kidney graft recipient from 1975 to 1999, received a second graft in 2001. The donor age was 65 years (cold ischemia 22 hours; two mismatches). The early posttransplant follow-up was characterized by delayed graft function, hypertension, and diabetes. During the initial hypertension workup, renal graft ultrasound (US) Doppler demonstrated increased vascular resistances, stable over time (resistance index 0.74 to 0.77); renal scintiscan displayed homogeneously parenchymoa and angio-magnetic resonance imaging (MRI), an homogeneous parenchymal vascularization. Initial immunosuppression with tacrolimus and steroids was modulated by adding mycophenolate mofetil to taper tacrolimus (to reduce nephrotoxicity and hypertension). Despite this, kidney function slowly deteriorated; serum creatinine reached 3 to 3.5 mg/dL by the second year. After a severe hypertensive crisis with unchanged scintiscan and US doppler examinations, angio-MRI revealed the almost complete disappearance of parenchymal enhancement beyond the lobar arteries. A renal biopsy confirmed the severe vascular damage. The patient was switched to rapamycine and a low-dose of an angiotension converting enzyme (ACE) inhibitor. She did relatively well (serum creatinine 2.2 to 3 mg/dL) for 6 months, when rapid functional impairment forced her to restart hemodialysis. This case, almost paradigmatic of the problems occurring when the rigid vasculature of long-term dialysis patients is matched with "marginal kidneys," suggests that MRI may be a sensible good to define vascular damage in the grafted kidney.

  12. Ubiquitin Accumulation on Disease Associated Protein Aggregates Is Correlated with Nuclear Ubiquitin Depletion, Histone De-Ubiquitination and Impaired DNA Damage Response.

    Directory of Open Access Journals (Sweden)

    Adi Ben Yehuda

    Full Text Available Deposition of ubiquitin conjugates on inclusion bodies composed of protein aggregates is a definitive cytopathological hallmark of neurodegenerative diseases. We show that accumulation of ubiquitin on polyQ IB, associated with Huntington's disease, is correlated with extensive depletion of nuclear ubiquitin and histone de-ubiquitination. Histone ubiquitination plays major roles in chromatin regulation and DNA repair. Accordingly, we observe that cells expressing IB fail to respond to radiomimetic DNA damage, to induce gamma-H2AX phosphorylation and to recruit 53BP1 to damaged foci. Interestingly ubiquitin depletion, histone de-ubiquitination and impaired DNA damage response are not restricted to PolyQ aggregates and are associated with artificial aggregating luciferase mutants. The longevity of brain neurons depends on their capacity to respond to and repair extensive ongoing DNA damage. Impaired DNA damage response, even modest one, could thus lead to premature neuron aging and mortality.

  13. Damage evaluation of 500 MWe Indian Pressurized Heavy Water Reactor nuclear containment for aircraft impact

    Energy Technology Data Exchange (ETDEWEB)

    Kukreja, Mukesh [Reactor Safety Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085 (India)]. E-mail: mrkukreja@yahoo.com

    2005-08-01

    Safety assessment of Indian nuclear containments has been carried out for aircraft impact. The loading time history for Boeing and Airbus categories of aircrafts is generated based on the principle of momentum transfer of crushable aircrafts. The case studies include the analysis of BWR Mark III containment as a benchmark problem and analyses of Pressurised Heavy Water Reactor containment (inner and outer containment) for impulsive loading due to aircraft impact. Initially, the load is applied on outer containment wall model and subsequently the load is transferred to inner containment after the local perforation of the outer containment wall is noticed in the transient simulation. The analysis methodology evolved in the present work would be useful for studying the behavior of double containment walls and multi barrier structural configurations for aircraft impact with higher energies. The present analysis illustrates that with the provision of double containments for Indian nuclear power plants, adequate reserve strength is available for the case of an extremely low probability event of missile impact generated due to the commercial aircrafts operated in India.

  14. Damage evaluation of 500 MWe Indian Pressurized Heavy Water Reactor nuclear containment for aircraft impact

    International Nuclear Information System (INIS)

    Kukreja, Mukesh

    2005-01-01

    Safety assessment of Indian nuclear containments has been carried out for aircraft impact. The loading time history for Boeing and Airbus categories of aircrafts is generated based on the principle of momentum transfer of crushable aircrafts. The case studies include the analysis of BWR Mark III containment as a benchmark problem and analyses of Pressurised Heavy Water Reactor containment (inner and outer containment) for impulsive loading due to aircraft impact. Initially, the load is applied on outer containment wall model and subsequently the load is transferred to inner containment after the local perforation of the outer containment wall is noticed in the transient simulation. The analysis methodology evolved in the present work would be useful for studying the behavior of double containment walls and multi barrier structural configurations for aircraft impact with higher energies. The present analysis illustrates that with the provision of double containments for Indian nuclear power plants, adequate reserve strength is available for the case of an extremely low probability event of missile impact generated due to the commercial aircrafts operated in India

  15. Monitoring and modeling stress corrosion and corrosion fatigue damage in nuclear reactors

    International Nuclear Information System (INIS)

    Andresen, P.L.; Ford, F.P.; Solomon, H.D.; Taylor, D.F.

    1990-01-01

    Stress corrosion and corrosion fatigue are significant problems in many industries, causing economic penalties from decreased plant availability and component repair or replacement. In nuclear power reactors, environmental cracking occurs in a wide variety of components, including reactor piping and steam generator tubing, bolting materials and pressure vessels. Life assessment for these components is complicated by the belief that cracking is quite irreproducible. Indeed, for conditions which were once viewed as nominally similar, orders of magnitude variability in crack growth rates are observed for stress corrosion and corrosion fatigue of stainless steels and low-alloy steels in 288 degrees C water. This paper shows that design and life prediction approaches are destined to be overly conservative or to risk environmental failure if life is predicted by quantifying only the effects of mechanical parameters and/or simply ignoring or aggregating environmental and material variabilities. Examples include the Nuclear Regulatory Commission (NRC) disposition line for stress-corrosion cracking of stainless steel in boiling water reactor (BWR) water and the American Society of Mechanical Engineers' Section XI lines for corrosion fatigue

  16. LORD-Q: a long-run real-time PCR-based DNA-damage quantification method for nuclear and mitochondrial genome analysis

    Science.gov (United States)

    Lehle, Simon; Hildebrand, Dominic G.; Merz, Britta; Malak, Peter N.; Becker, Michael S.; Schmezer, Peter; Essmann, Frank; Schulze-Osthoff, Klaus; Rothfuss, Oliver

    2014-01-01

    DNA damage is tightly associated with various biological and pathological processes, such as aging and tumorigenesis. Although detection of DNA damage is attracting increasing attention, only a limited number of methods are available to quantify DNA lesions, and these techniques are tedious or only detect global DNA damage. In this study, we present a high-sensitivity long-run real-time PCR technique for DNA-damage quantification (LORD-Q) in both the mitochondrial and nuclear genome. While most conventional methods are of low-sensitivity or restricted to abundant mitochondrial DNA samples, we established a protocol that enables the accurate sequence-specific quantification of DNA damage in >3-kb probes for any mitochondrial or nuclear DNA sequence. In order to validate the sensitivity of this method, we compared LORD-Q with a previously published qPCR-based method and the standard single-cell gel electrophoresis assay, demonstrating a superior performance of LORD-Q. Exemplarily, we monitored induction of DNA damage and repair processes in human induced pluripotent stem cells and isogenic fibroblasts. Our results suggest that LORD-Q provides a sequence-specific and precise method to quantify DNA damage, thereby allowing the high-throughput assessment of DNA repair, genotoxicity screening and various other processes for a wide range of life science applications. PMID:24371283

  17. The convention on supplementary compensation for nuclear damage and asian states: the advantages and disadvantages of Korea's adherence to the convention

    International Nuclear Information System (INIS)

    Park, K.G.

    2000-01-01

    This paper intends to make some assessments of the advantages and disadvantages which would result from Korea's ratification of the Convention on Supplementary Compensation for Nuclear Damage (CSC), opened for signature on 29 September 1997 in Vienna, Austria. I have presented elsewhere a view on the creation of an Asian regional regime in the event of a transboundary nuclear accident, but here I will focus on the applicability of a global regime especially to Asian States. (author)

  18. Environmental impact of nuclear industry and power generation in the Russian Federation: assessment of contribution to general damage

    International Nuclear Information System (INIS)

    Vetrov, V.

    2002-01-01

    wastewater, agriculture, communal effluents, wash-off from polluted watershed. Among the vast amount of surface freshwater resource in Russia, it is only in the Techa River (The Mayak Combined Works impact zone, Urals, Ob river basin) that the technogenous 90 Sr concentrations are close to or exceeds MPC for drinking water. The total area of forests loss in the RF as a result of radioactive contamination throughout the nuclear history is approximately one order of magnitude less than those distracted by cumulative man-made factors during just 1998. Therefore, a simple analysis allows a conclusion that the leading nuclear industry enterprises are out of the list of major sources of hazardous pollution and environmental damage in the provinces of their locations

  19. Those who 'Cry Wolf' about nuclear safety damage their own credibility

    Energy Technology Data Exchange (ETDEWEB)

    Shepherd, John [nuclear 24, Redditch (United Kingdom)

    2016-06-15

    Do you recall the fable of the boy who cried wolf? I was reminded of this following the latest call by Germany's Federal Environment Minister, Barbara Hendricks, for Belgium to take two of its nuclear reactors off the grid, citing ''questions'' about the units' safety. Those in positions of power and influence in one country should take care to be as responsible in their dealings with their neighbours as they are in handling domestic matters of state. Those who see 'danger' where there is none are not being good neighbours. They are generating fear and alarm without good cause and should mind their own business.

  20. International Court of Justice on Potential Transboundary Damage and its Consequences in Nuclear Law

    International Nuclear Information System (INIS)

    Cletienne, M.

    2010-01-01

    On 4 May 2006, Argentina filed in the International Court of Justice ('ICJ') an application instituting proceedings against Uruguay. Argentina claimed that Uruguay, by authorizing the construction of a pulp mill (the 'CMB mill') and the construction and commissioning of another pulp mill (the 'Orion mill'), breached its obligations under the 1975 Statute of the River Uruguay, a treaty between Argentina and Uruguay, notably the obligation to take all necessary measures for the optimum and rational utilisation of the River Uruguay. On 20 April 2010,1 the court rendered its decision settling this environmental dispute between Argentina and Uruguay. This paper will first summarize the judgement and then consider the main contribution of this decision to international environmental law, e.g. the recognition of an international customary rule to conduct an environmental impact assessment. Finally, the potential consequences of the decision in nuclear law will be addressed in the last part

  1. Damage evaluation of 500 MWe Indian pressurized heavy water reactor nuclear containment for air craft impact

    International Nuclear Information System (INIS)

    Kukreja, Mukesh; Singh, R.K; Vaze, K.K; Kushwaha, H.S.

    2003-01-01

    Non-linear transient dynamic analysis of 500 MWe Indian Pressurized Heavy Water Reactor (PHWR) nuclear containment has been carried out for the impact of Boeing and Airbus category of aircraft operated in India. The impulsive load time history is generated based on the momentum transfer of the crushable aircraft (soft missiles) of Boeing and Airbus families on the containment structure. The case studies include the analyses of outer containment wall (OCW) single model and the combined model with outer and inner containment wall (ICW) for impulsive loading due to aircraft impact. Initially the load is applied on OCW single model and subsequently the load is transferred to ICW after the local perforation of the OCW is noticed in the transient simulation. In the first stage of the analysis it is demonstrated that the OCW would suffer local perforation with a peak local deformation of 117 mm for impact due to B707-320 and 196 mm due to impact of A300B4 without loss of the overall integrity. However, this first barrier (OCW) cannot absorb the full impulsive load. In the second stage of the analysis of the combined model, the ICW is subjected to lower impulse duration as the load is transferred after 0.19 sec for B707-320 and 0.24 sec for A300B4 due to the local perforation of OCW. This results in the local deformation of approx. 115 mm for B707-320 and 124 mm for A300B4 in ICW and together both the structures (OCW and ICW) are capable of absorbing the full impulsive load. The analysis methodology evolved in the present work would be useful for studying the behaviour of double containment walls and multi barrier structural configurations for aircraft impact with higher energies. The present analysis illustrates that with the provision of double containments for Indian nuclear power plants, adequate reserve strength is available for the case of an extremely low probability event of missile impact generated due commercial aircraft operated in India. (author)

  2. Morocco. Act no. 12-02 on civil liability for nuclear damage. Promulgated on 7 january 2005. Chapter 1. General provisions

    International Nuclear Information System (INIS)

    Anon.

    2005-01-01

    Three texts concern Morocco with the Act on civil liability for Nuclear damage (2005), International Atomic energy Agency with the code of conduct on the safety of research reactors (2004), United Nations with U.N. Security Council Resolution 1540 (2004). (N.C.)

  3. Economic models of compensation for damages caused by nuclear accidents: some lessons for the revision of the Paris and Vienna Conventions

    International Nuclear Information System (INIS)

    Faure, Michael G.

    1995-01-01

    Alternative systems of compensation for damages caused by nuclear accidents have been proposed. In respect, the question merits attention to whether these alternative models of compensation discussed in the economic literature could be implemented when discussing the revision of the Paris and Vienna Conventions. 55 refs., 1 tab

  4. RAD18 and associated proteins are immobilized in nuclear foci in human cells entering S-phase with ultraviolet light-induced damage

    International Nuclear Information System (INIS)

    Watson, Nicholas B.; Nelson, Eric; Digman, Michelle; Thornburg, Joshua A.; Alphenaar, Bruce W.; McGregor, W. Glenn

    2008-01-01

    Proteins required for translesion DNA synthesis localize in nuclear foci of cells with replication-blocking lesions. The dynamics of this process were examined in human cells with fluorescence-based biophysical techniques. Photobleaching recovery and raster image correlation spectroscopy experiments indicated that involvement in the nuclear foci reduced the movement of RAD18 from diffusion-controlled to virtual immobility. Examination of the mobility of REV1 indicated that it is similarly immobilized when it is observed in nuclear foci. Reducing the level of RAD18 greatly reduced the focal accumulation of REV1 and reduced UV mutagenesis to background frequencies. Fluorescence lifetime measurements indicated that RAD18 and RAD6A or polη only transferred resonance energy when these proteins colocalized in damage-induced nuclear foci, indicating a close physical association only within such foci. Our data support a model in which RAD18 within damage-induced nuclear foci is immobilized and is required for recruitment of Y-family DNA polymerases and subsequent mutagenesis. In the absence of damage these proteins are not physically associated within the nucleoplasm

  5. Inducibility of nuclear Rad51 foci after DNA damage distinguishes all Fanconi anemia complementation groups from D1/BRCA2

    Energy Technology Data Exchange (ETDEWEB)

    Godthelp, Barbara C. [Department of Toxicogenetics, Leiden University Medical Center, Wassenaarseweg 72, NL-2333 AL Leiden (Netherlands); Wiegant, Wouter W. [Department of Toxicogenetics, Leiden University Medical Center, Wassenaarseweg 72, NL-2333 AL Leiden (Netherlands); Waisfisz, Quinten [Department of Clinical Genetics and Human Genetics, Free University Medical Center, Van der Boechorststraat 7, NL-1081 BT Amsterdam (Netherlands); Medhurst, Annette L. [Department of Clinical Genetics and Human Genetics, Free University Medical Center, Van der Boechorststraat 7, NL-1081 BT Amsterdam (Netherlands); Arwert, Fre [Department of Clinical Genetics and Human Genetics, Free University Medical Center, Van der Boechorststraat 7, NL-1081 BT Amsterdam (Netherlands); Joenje, Hans [Department of Clinical Genetics and Human Genetics, Free University Medical Center, Van der Boechorststraat 7, NL-1081 BT Amsterdam (Netherlands); Zdzienicka, Malgorzata Z. [Department of Toxicogenetics, Leiden University Medical Center, Wassenaarseweg 72, NL-2333 AL Leiden (Netherlands) and Department of Molecular Cell Genetics, Collegium Medicum, N. Copernicus University, Bydgoszcz (Poland)]. E-mail: m.z.zdzienicka@lumc.nl

    2006-02-22

    Fanconi anemia (FA) is a cancer susceptibility disorder characterized by chromosomal instability and hypersensitivity to DNA cross-linking agents. So far 11 complementation groups have been identified, from which only FA-D1/BRCA2 and FA-J are defective downstream of the central FANCD2 protein as cells from these groups are capable of monoubiquitinating FANCD2. In this study we show that cells derived from patients from the new complementation groups, FA-I, FA-J and FA-L are all proficient in DNA damage induced Rad51 foci formation, making the cells from FA-D1/BRCA2 patients that are defective in this process the sole exception. Although FA-B patient HSC230 was previously reported to also have biallelic BRCA2 mutations, we found normal Rad51 foci formation in cells from this patient, consistent with the recent identification of an X-linked gene being mutated in four unrelated FA-B patients. Thus, our data show that none of the FA proteins, except BRCA2, are required to sequester Rad51 into nuclear foci. Since cells from the FA-D1 and FA-J patient groups are both able to monoubiquitinate FANCD2, the 'Rad51 foci phenotype' provides a convenient assay to distinguish between these two groups. Our results suggest that FANCJ and FANCD1/BRCA2 are part of the integrated FANC/BRCA DNA damage response pathway or, alternatively, that they represent sub-pathways in which only FANCD1/BRCA2 is directly connected to the process of homologous recombination.

  6. Inducibility of nuclear Rad51 foci after DNA damage distinguishes all Fanconi anemia complementation groups from D1/BRCA2

    International Nuclear Information System (INIS)

    Godthelp, Barbara C.; Wiegant, Wouter W.; Waisfisz, Quinten; Medhurst, Annette L.; Arwert, Fre; Joenje, Hans; Zdzienicka, Malgorzata Z.

    2006-01-01

    Fanconi anemia (FA) is a cancer susceptibility disorder characterized by chromosomal instability and hypersensitivity to DNA cross-linking agents. So far 11 complementation groups have been identified, from which only FA-D1/BRCA2 and FA-J are defective downstream of the central FANCD2 protein as cells from these groups are capable of monoubiquitinating FANCD2. In this study we show that cells derived from patients from the new complementation groups, FA-I, FA-J and FA-L are all proficient in DNA damage induced Rad51 foci formation, making the cells from FA-D1/BRCA2 patients that are defective in this process the sole exception. Although FA-B patient HSC230 was previously reported to also have biallelic BRCA2 mutations, we found normal Rad51 foci formation in cells from this patient, consistent with the recent identification of an X-linked gene being mutated in four unrelated FA-B patients. Thus, our data show that none of the FA proteins, except BRCA2, are required to sequester Rad51 into nuclear foci. Since cells from the FA-D1 and FA-J patient groups are both able to monoubiquitinate FANCD2, the 'Rad51 foci phenotype' provides a convenient assay to distinguish between these two groups. Our results suggest that FANCJ and FANCD1/BRCA2 are part of the integrated FANC/BRCA DNA damage response pathway or, alternatively, that they represent sub-pathways in which only FANCD1/BRCA2 is directly connected to the process of homologous recombination

  7. Safety and dose management during decommissioning of a fire damaged nuclear reactor

    International Nuclear Information System (INIS)

    Pomfret, D.G.

    2000-01-01

    Windscale Piles 1 and 2 in Cumbria in the UK were constructed in the early 1950s. They were not intended to produce electricity but were for military purposes only. They were graphite-moderated, air-cooled reactors with horizontal fuel channels fuelled with uranium rods clad in finned aluminium. In October 1957, Windscale Pile 1 suffered a core fire during a planned release of Wigner energy and both Piles were subsequently closed down. Following the fire, Pile 2 was defuelled entirely and as much fuel as was possible was removed from Pile 1. However, it is estimated that up to 15 Te of fuel remains in the core, a large proportion of which is located in the central Fire Affected Zone (FAZ). The condition of the fuel and graphite moderator in the FAZ is not known. It is possible that the moderator could contain voidage, greatly reduced density graphite and fused materials in a disordered matrix. It is probable that there is residual Wigner energy in the graphite. Use of water as part of the attempt to extinguish the fire, together with the possibility that the solidification of molten materials or other local sealing mechanisms could have excluded air mean that uranium hydrides, carbides and other pyrophorics may be present within the core. Pile 1 is now being decommissioned and a considerable amount of preparatory work has already been carried out during Phase 1. Phase 2 decommissioning, which will remove the residual fuel, the moderator and associated steelwork, condition the wastes and place them in a purpose built store is now underway. This work will be carried out for the site licensee, the United Kingdom Energy Authority, by a consortium of British Nuclear Fuels plc, Rolls Royce and NUKEM. This paper will describe the methods to be used to decommission Pile 1 and the systems and procedures which will be used to ensure that it is done safely and with the lowest reasonably practicable environmental impact. It will also describe the methods which will be used to

  8. Hydrogen peroxide-induced DNA damage is independent of nuclear calcium but dependent on redox-active ions.

    Science.gov (United States)

    Jornot, L; Petersen, H; Junod, A F

    1998-01-01

    In cells undergoing oxidative stress, DNA damage may result from attack by .OH radicals produced by the Fenton reaction, and/or by nucleases activated by nuclear calcium. In the present study, the participation of these two mechanisms was investigated in HeLa cells. Nuclear-targeted aequorin was used for selectively monitoring Ca2+ concentrations within the nuclei ([Ca2+]n), in conjunction with the cell-permeant calcium chelator bis-(o-aminophenoxy)ethane-N,N,N', N'-tetraacetic acid acetoxymethyl ester (BAPTA/AM), the lipid-soluble broad-spectrum metal chelator with low affinity for Ca2+ and Mg2+ N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN), and the high-affinity iron/copper chelator 1, 10-phenanthroline (PHE). In Ca2+-containing medium, H2O2 induced extensive DNA strand breaks and an increase in [Ca2+]n that was almost identical to that observed in the cytosol ([Ca2+]c). In cells bathed in Ca2+-free/EGTA medium, in which the increases in [Ca2+]n and [Ca2+]c due to H2O2 were significantly reduced, similar levels of DNA fragmentation also occurred. In cells preloaded with BAPTA/AM or TPEN, the small increase of [Ca2+]n normally elicited by H2O2 in Ca2+-free medium was completely buffered, and DNA damage was largely prevented. On the other hand, pretreatment with PHE did not affect the calcium response in the nuclei, but completely prevented DNA strand breakage induced by H2O2. Re-addition of 100 microM CuSO4 and 100 microM FeSO4 to TPEN- and PHE-treated cells prior to H2O2 challenge reversed the effect of TPEN and PHE, whereas 1 mM was necessary to negate the effect of BAPTA/AM. The levels of DNA strand breakage observed, however, did not correlate with the amounts of 8-hydroxy 2'-deoxyguanosine (8-OHdG): H2O2 did not produce 8-OHdG, whereas PHE alone slightly increased 8-OHdG levels. CuSO4 and FeSO4 enhanced the effects of PHE, particularly in the presence of H2O2. Exposure of cells to a mixture of CuSO4/FeSO4 also resulted in a significant increase in

  9. Liability for nuclear damage: financial and definitional limitations with particular reference to the EEC rules prohibiting subsidies and anti-competitive practices and agreements

    International Nuclear Information System (INIS)

    Sands, P.

    1992-01-01

    In March 1990 the Commission of the European Communities (EEC) held that a package of state aids (subsidies) to the United Kingdom nuclear industry were compatible with Article 92 of the EEC Treaty. The decision was significant because it held that the package of measures constituted ''state aids'' and that the nuclear industry was subject to Article 92 of the EEC Treaty; and it set some of the parameters to determine the conditions under which the Commission will authorise such state aids. The decision has implications for the emerging rules governing civil liability for damage caused by waste, including nuclear waste, currently being prepared by the EC Commission and the International Atomic Energy Agency Standing Committee on Nuclear Liability. (author)

  10. Analysis of the microstructural evolution of the damage by neutron irradiation in the pressure vessel of a nuclear power reactor BWR

    International Nuclear Information System (INIS)

    Moranchel y R, M.

    2012-01-01

    Nuclear reactor pressure vessel type BWR, installed in Mexico and in many other countries, are made of an alloy of low carbon steel. The American Society for Testing and Materials (Astm) classifies this alloy as A533-B, class 1. Both the vessel and other internal structures are continuously exposed to the neutron flux from the reactions of fission in nuclear fuel. A large number of neutrons reach the vessel and penetrate certain depth depending on their energy. Its penetration in the neutron collides with the nuclei of the atoms out of their positions in the crystal lattice of steel, producing vacancies, interstitial, segregations, among other defects, capable of affecting its mechanical properties. Analyze the micro-structural damage to the vessel due to neutron irradiation, is essential for reasons of integrity of this enclosure and safety of any nuclear power plant. The objective of this thesis work is theoretical and experimentally determine the microstructural damage of a type nuclear reactor vessel steel BWR, due to neutron radiation from the reactor core, using microscopic and spectroscopic techniques as well as Monte Carlo simulation. Microscopy Optical, Scanning Electron Microscopy, Transmission Electron Microscopy, Energy Dispersion of X-rays Spectrometry and X-rays Diffractometry were the techniques used in this research. These techniques helped in the characterization of both the basis of design of pressure vessel steel and steel irradiated, after eight years of neutron irradiation on the vessel, allowing know the surface morphology and crystal structures of the previous steel and post-irradiation, analyze the change in the microstructure of the steel vessel, morphological damage to surface level in an irradiated sample, among which are cavities in the order of microns produced by Atomic displacements due to the impact of neutronic, above all in the first layers of thickness of the vessel, the effect of swelling, regions of greater damage and Atomic

  11. Diffusional mass transport phenomena in the buffer material and damaged zone of a borehole wall in an underground nuclear fuel waste vault

    International Nuclear Information System (INIS)

    Page, S.; Cheung, S.C.H.

    1983-06-01

    The effects of the geometry of the borehole and the characteristics of the damaged borehole rock wall on the movement of the radionuclides from an underground nuclear waste vault have been studied. The results show that radionuclide transport will occur mainly through the buffer into the damaged zone of the borehole wall. As the degree of facturing of the damaged zone increases, the total radionuclide flux will increase up to a limit which can be approximated by a one-dimensional radial diffusion model. For large degrees of fracturing of the damaged zone, an increase in the radial buffer material thickness will decrease the total flux, whereas, for small degrees of fracturing, an increase in the radial buffer thickness may slightly increase the total flux. Increasing the vertical buffer thickness will significantly decrease the total flux when the degree of fracturing of the damaged zone is small. An increase in the vertical extent of the damaged zone will cause an increase in total flux

  12. A three-dimensional methodology for the assessment of neutron damage and nuclear energy deposition in graphite components of advanced gas-cooled reactors

    Energy Technology Data Exchange (ETDEWEB)

    Morgan, D.O.; Robinson, A.T.; Allen, D.A.; Picton, D.J.; Thornton, D.A. [TCS, Serco, Rutherford House, Olympus Park, Quedgeley, Gloucester, Gloucestershire GL2 4NF (United Kingdom); Shaw, S.E. [EDF Energy, Barnet Way, Barnwood, Gloucester GL4 3RS (United Kingdom)

    2011-07-01

    This paper describes the development of a three-dimensional methodology for the assessment of neutron damage and nuclear energy deposition (or nuclear heating) throughout the graphite cores of the UK's Advanced Gas-cooled Reactors. Advances in the development of the Monte Carlo radiation transport code MCBEND have enabled the efficient production of detailed fully three-dimensional models that utilise three-dimensional source distributions obtained from Core Follow data supplied by the reactor physics code PANTHER. The calculational approach can be simplified to reduce both the requisite number of intensive radiation transport calculations, as well as the quantity of data output. These simplifications have been qualified by comparison with explicit calculations and they have been shown not to introduce significant systematic uncertainties. Simple calculational approaches are described that allow users of the data to address the effects on neutron damage and nuclear energy deposition predictions of the feedback resulting from the mutual dependencies of graphite weight loss and nuclear energy deposition. (authors)

  13. Cumulative damage fatigue tests on nuclear reactor Zircaloy-2 fuel tubes at room temperature and 3000C

    International Nuclear Information System (INIS)

    Pandarinathan, P.R.; Vasudevan, P.

    1980-01-01

    Cumulative damage fatigue tests were conducted on the Zircaloy-2 fuel tubes at room temperature and 300 0 C on the modified Moore type, four-point-loaded, deflection-controlled, rotating bending fatigue testing machine. The cumulative cycle ratio at fracture for the Zircaloy-2 fuel tubes was found to depend on the sequence of loading, stress history, number of cycles of application of the pre-stress and the test temperature. A Hi-Lo type fatigue loading was found to be very much damaging at room temperature and this feature was not observed in the tests at 300 0 C. Results indicate significant differences in damage interaction and damage propagation under cumulative damage tests at room temperature and at 300 0 C. Block-loading fatigue tests are suggested as the best method to determine the life-time of Zircaloy-2 fuel tubes under random fatigue loading during their service in the reactor. (orig.)

  14. Claims Handling Co-operation between Nuclear Insurance Pools in a Case of Transboundary Damage - Multilateral and Bilateral Agreements in Progress

    International Nuclear Information System (INIS)

    Zaruba, P.

    2008-01-01

    The paper is a short progress report on matters concerning the core reason for insurance of nuclear third party liability - registration, handling, organizing and settling of claims in case of a major nuclear incident, underlining claims handling co-operation between national nuclear insurance pools when damage to health or property becomes international. The contents of this paper is in close relation to information provided on this subject during the 6th International Conference in 2006. Commercial insurance companies have gained extensive experience with handling large scale claims (e.g. after floods and other natural disasters) and are capable in gathering and organizing a high number of professional loss surveyors and adjusters in a very short period of time. In case of nuclear insurance pools co-operation between members (commercial insurance companies) is an added value and can be used practically all over the country bringing into action the network of branches and offices of all the pool members. This advantage is also used in case of cross border claims when it is necessary to gather information and claims advises from a large number of subjects and from many countries, sometimes very far apart. The international network of nuclear insurance pools is an ideal tool for this task and can be mobilized practically at once. Operators of nuclear installations, especially nuclear power plants, do not have the possibility to put aside hundreds of workers to handle claims and are also usually not sufficiently equipped with the necessary know-how. The same goes for governments and government agencies which in many countries guarantee the payments of claims to victims. National nuclear insurance pools are on the other hand well equipped for this task which usually has to be in place for many years after a nuclear incident. Multilateral and bilateral agreements between national nuclear insurance pools and other institutions should be prepared and signed before any

  15. Investigating α-particle radiation damage in phyllosilicates using synchrotron microfocus-XRD/XAS: implications for geological disposal of nuclear waste

    Science.gov (United States)

    Bower, W. R.; Pearce, C. I.; Pimblott, S. M.; Haigh, S. J.; Mosselmans, J. F. W.; Pattrick, R. A. D.

    2014-12-01

    The response of mineral phases to the radiation fields that will be experienced in a geological disposal facility (GDF) for nuclear waste is poorly understood. Phyllosilicates are critical phases in a GDF with bentonite clay as the backfill of choice surrounding high level wastes in the engineered barrier, and clays and micas forming the most important reactive component of potential host rocks. It is essential that we understand changes in mineral properties and behaviour as a result of damage from both α and γ radiation over long timescales. Radiation damage has been demonstrated to affect the physical integrity and oxidation state1 of minerals which will also influence their ability to react with radionuclides. Using the University of Manchester's newly commissioned particle accelerator at the Dalton Cumbrian Facility, UK, model phyllosilicate minerals (e.g. biotite, chlorite) were irradiated with high energy (5MeV) alpha particles at controlled dose rates. This has been compared alongside radiation damage found in naturally formed 'radiohalos' - spherical areas of discolouration in minerals surrounding radioactive inclusions, resulting from alpha particle penetration, providing a natural analogue to study lattice damage under long term bombardment1,2. Both natural and artificially irradiated samples have been analysed using microfocus X-ray absorption spectroscopy and high resolution X-ray diffraction mapping on Beamline I18 at Diamond Light Source; samples were probed for redox changes and long/short range disorder. This was combined with lattice scale imaging of damage using HR-TEM (TitanTM Transmission Electron Microscope). The results show aberrations in lattice parameters as a result of irradiation, with multiple damage-induced 'domains' surrounded by amorphous regions. In the naturally damaged samples, neo-formed phyllosilicate phases are shown to be breakdown products of highly damaged regions. A clear reduction of the Fe(III) component has been

  16. Probabilistic residual life assessment of high temperature pipings in nuclear power plants against creep fatigue damage: final report

    International Nuclear Information System (INIS)

    Gupta, Sanjay

    2014-02-01

    Residual life assessment of components of nuclear power plants is essential for their operational safety, reliability and financial viability. The high risks involved in the event of failures in nuclear power plants have led to the development of design philosophies that incorporate extreme conservatism in design. The implications of such conservatism in design leads to more frequent maintenance operations than necessary

  17. The Convention on Supplementary Compensation for Nuclear Damage and participation by developing countries: A South African perspective

    International Nuclear Information System (INIS)

    Davies, David B.

    2014-01-01

    This article contends that it is essential that new entrant countries into the nuclear energy industry have comprehensive nuclear legislation; it is less clear, however, whether new entrant countries find it essential to join any of the various international nuclear liability conventions, as some countries have been slow or resistant to the idea. This article will take a closer look at the potential influencing factors driving membership or non-membership in the CSC by a developing country. First, however, is a discussion of the basic principles of international nuclear third party liability, the CSC itself, developing countries' current participation in the various international nuclear liability conventions and the advantages and disadvantages of the CSC. The author's views regarding participation by a developing country in the CSC will also be presented. (author)

  18. Investigation of a Novel NDE Method for Monitoring Thermomechanical Damage and Microstructure Evolution in Ferritic-Martensitic Steels for Generation IV Nuclear Energy Systems

    Energy Technology Data Exchange (ETDEWEB)

    Nagy, Peter

    2013-09-30

    The main goal of the proposed project is the development of validated nondestructive evaluation (NDE) techniques for in situ monitoring of ferritic-martensitic steels like Grade 91 9Cr-1Mo, which are candidate materials for Generation IV nuclear energy structural components operating at temperatures up to ~650{degree}C and for steam-generator tubing for sodium-cooled fast reactors. Full assessment of thermomechanical damage requires a clear separation between thermally activated microstructural evolution and creep damage caused by simultaneous mechanical stress. Creep damage can be classified as "negligible" creep without significant plastic strain and "ordinary" creep of the primary, secondary, and tertiary kind that is accompanied by significant plastic deformation and/or cavity nucleation and growth. Under negligible creep conditions of interest in this project, minimal or no plastic strain occurs, and the accumulation of creep damage does not significantly reduce the fatigue life of a structural component so that low-temperature design rules, such as the ASME Section III, Subsection NB, can be applied with confidence. The proposed research project will utilize a multifaceted approach in which the feasibility of electrical conductivity and thermo-electric monitoring methods is researched and coupled with detailed post-thermal/creep exposure characterization of microstructural changes and damage processes using state-of-the-art electron microscopy techniques, with the aim of establishing the most effective nondestructive materials evaluation technique for particular degradation modes in high-temperature alloys that are candidates for use in the Next Generation Nuclear Plant (NGNP) as well as providing the necessary mechanism-based underpinnings for relating the two. Only techniques suitable for practical application in situ will be considered. As the project evolves and results accumulate, we will also study the use of this technique for monitoring other GEN IV

  19. Protocols to Amend the Paris, Vienna and Brussels Supplementary Conventions and the Convention on Supplementary Compensation for Nuclear Damage: Status of their Implementation into National Legislation

    International Nuclear Information System (INIS)

    Schwartz, J.

    2006-01-01

    Over the last decade, a number of very significant developments have taken place in modernising the existing international nuclear liability regimes. The first major advancement was the adoption, in September 1997, of the Protocol to amend the 1963 Vienna Convention on Civil Liability for Nuclear Damage (VC Protocol) and of a new Convention on Supplementary Compensation for Nuclear Damage (CSC). This was followed, in February 2004, by the adoption of Protocols to amend both the 1960 Paris Convention on Third Party Liability in the Field of Nuclear Energy (PC Protocol) and the 1963 Brussels Convention Supplementary to the Paris Convention (BSC Protocol). The principle goal of all these new instruments is to provide a greater amount of compensation to a larger number of victims in respect of a broader scope of nuclear damage suffered as a result of a nuclear accident. The second, but still very important objective is the maintenance of compatibility between the revised Paris and Vienna Conventions to ensure the smooth functioning of the 1988 Joint Protocol Relating to the Application of the Vienna Convention (VC) and the Paris Convention (PC). In addition, the PC States wish to ensure that their newly revised Convention will not prevent a Contracting Party from joining the more global regime established by the CSC. However, it remains to be seen to what extent these new instruments will attract a sufficient number of adherents to make them truly effective. While the VC Protocol is already in force, it has not drawn wide support from the 1963 VC States or from countries with important nuclear generating capacity which have not yet joined that latter any Convention. In addition, notwithstanding its adoption almost 10 years ago, the CSC has not yet entered into force and it remains questionable whether it will ever attract the necessary number of adherents for that purpose, especially in light of its strict requirements in this regard. As for the PC and BSC Protocols to

  20. Nuclear DNA damage-triggered NLRP3 inflammasome activation promotes UVB-induced inflammatory responses in human keratinocytes

    International Nuclear Information System (INIS)

    Hasegawa, Tatsuya; Nakashima, Masaya; Suzuki, Yoshiharu

    2016-01-01

    Ultraviolet (UV) radiation in sunlight can result in DNA damage and an inflammatory reaction of the skin commonly known as sunburn, which in turn can lead to cutaneous tissue disorders. However, little has been known about how UV-induced DNA damage mediates the release of inflammatory mediators from keratinocytes. Here, we show that UVB radiation intensity-dependently increases NLRP3 gene expression and IL-1β production in human keratinocytes. Knockdown of NLRP3 with siRNA suppresses UVB-induced production of not only IL-1β, but also other inflammatory mediators, including IL-1α, IL-6, TNF-α, and PGE_2. In addition, inhibition of DNA damage repair by knockdown of XPA, which is a major component of the nucleotide excision repair system, causes accumulation of cyclobutane pyrimidine dimer (CPD) and activation of NLRP3 inflammasome. In vivo immunofluorescence analysis confirmed that NLRP3 expression is also elevated in UV-irradiated human epidermis. Overall, our findings indicate that UVB-induced DNA damage initiates NLRP3 inflammasome activation, leading to release of various inflammatory mediators from human keratinocytes. - Highlights: • UVB radiation induces NLRP3 inflammasome activation in human keratinocytes. • NLRP3 knockdown suppresses production of UVB-induced inflammatory mediators. • UVB-induced DNA damage triggers NLRP3 inflammasome activation. • NLRP3 expression in human epidermis is elevated in response to UV radiation.

  1. Nuclear DNA damage-triggered NLRP3 inflammasome activation promotes UVB-induced inflammatory responses in human keratinocytes

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Tatsuya, E-mail: tatsuya.hasegawa@to.shiseido.co.jp; Nakashima, Masaya; Suzuki, Yoshiharu

    2016-08-26

    Ultraviolet (UV) radiation in sunlight can result in DNA damage and an inflammatory reaction of the skin commonly known as sunburn, which in turn can lead to cutaneous tissue disorders. However, little has been known about how UV-induced DNA damage mediates the release of inflammatory mediators from keratinocytes. Here, we show that UVB radiation intensity-dependently increases NLRP3 gene expression and IL-1β production in human keratinocytes. Knockdown of NLRP3 with siRNA suppresses UVB-induced production of not only IL-1β, but also other inflammatory mediators, including IL-1α, IL-6, TNF-α, and PGE{sub 2}. In addition, inhibition of DNA damage repair by knockdown of XPA, which is a major component of the nucleotide excision repair system, causes accumulation of cyclobutane pyrimidine dimer (CPD) and activation of NLRP3 inflammasome. In vivo immunofluorescence analysis confirmed that NLRP3 expression is also elevated in UV-irradiated human epidermis. Overall, our findings indicate that UVB-induced DNA damage initiates NLRP3 inflammasome activation, leading to release of various inflammatory mediators from human keratinocytes. - Highlights: • UVB radiation induces NLRP3 inflammasome activation in human keratinocytes. • NLRP3 knockdown suppresses production of UVB-induced inflammatory mediators. • UVB-induced DNA damage triggers NLRP3 inflammasome activation. • NLRP3 expression in human epidermis is elevated in response to UV radiation.

  2. A bridge between two conventions on civil liability for nuclear damage: The Joint Protocol relating to the application of the Vienna Convention and the Paris Convention

    International Nuclear Information System (INIS)

    Busekist, Otto von

    2006-01-01

    The adoption of the Joint Protocol and its signature on 21 September 1988, at the closure of the diplomatic conference jointly convened in Vienna by the IAEA and the NEA, was hailed as landmark in efforts towards the establishment of a comprehensive civil nuclear liability regime. The importance of liability and compensation for transfrontier damage caused by a nuclear incident is indeed one of the lessons learned from the Chernobyl accident. The present article attempts to describe the history of the Joint Protocol during the many years it took to develop this link between the two conventions, to provide comment on its objectives and content, and to discuss some important questions related to its application

  3. A bridge between two Conventions on civil liability for nuclear damage: the Joint protocol Relating to the application of the Vienna Convention and the Paris Convention

    International Nuclear Information System (INIS)

    Busekist, O. von.

    1989-01-01

    The adoption of the Joint-Protocol and its signature on 21 September 1988, at the closure of the diplomatic conference jointly convened in Vienna by the IAEA and NEA, was hailed as a landmark in efforts towards the establishment of a comprehensive civil nuclear liability regime. The importance of liability and compensation for transfrontier damage caused by a nuclear incident is indeed one of the lessons learned from the Chernobyl accident. This article describes the history of the Joint Protocol during the many years it took to develop this link between the two Conventions, provides a comment on its objectives and content, and discusses some important questions related to its application. (NEA) [fr

  4. Towards a global system of compensation for transboundary nuclear damage: reflexions on the interrelationship of civil and international state liability

    International Nuclear Information System (INIS)

    Handl, G.

    1993-01-01

    International state liability is an essential complementary element of any global and comprehensive nuclear compensation system. Civil liability alone will not be able to fully compensate victims of a nuclear accident and will therefore not fully internalize the costs of nuclear activities. To make it effective and politically acceptable, state liability must be fully integrated procedurally with any civil liability system as a last tier of compensation following a simple process for handling together both civil and state liability claims at the international level, with individuals being able to sue Installation States. 69 refs

  5. Medical treatment of radiation damages and medical emergency planning in case of nuclear power plant incidents and accidents

    International Nuclear Information System (INIS)

    Ohlenschlaeger, L.

    1981-03-01

    Medical measures in case of radiation damages are discussed on the basis of five potential categories of radiation incidents and accidents, respectively, viz. contaminations, incorporations, external local and general radiation over-exposures, contaminated wounds, and combinations of radiation damages and conventional injuries. Considerations are made for diagnostic and therapeutic initial measures especially in case of minor and moderate radiation accidents. The medical emergency planning is reviewed by means of definations used in the practical handling of incidents or accidents. The parameters are: extent of the incident or accident, number of persons involved, severity of radiation damage. Based on guiding symptoms the criteria for the classification into minor, moderate or severe radiation accidents are discussed. Reference is made to the Medical Radiation Protection Centers existing in the Federal Republic of Germany and the possibility of getting advices in case of radiation incidents and accidents. (orig.) [de

  6. Estimation of probability density functions of damage parameter for valve leakage detection in reciprocating pump used in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jong Kyeom; Kim, Tae Yun; Kim, Hyun Su; Chai, Jang Bom; Lee, Jin Woo [Div. of Mechanical Engineering, Ajou University, Suwon (Korea, Republic of)

    2016-10-15

    This paper presents an advanced estimation method for obtaining the probability density functions of a damage parameter for valve leakage detection in a reciprocating pump. The estimation method is based on a comparison of model data which are simulated by using a mathematical model, and experimental data which are measured on the inside and outside of the reciprocating pump in operation. The mathematical model, which is simplified and extended on the basis of previous models, describes not only the normal state of the pump, but also its abnormal state caused by valve leakage. The pressure in the cylinder is expressed as a function of the crankshaft angle, and an additional volume flow rate due to the valve leakage is quantified by a damage parameter in the mathematical model. The change in the cylinder pressure profiles due to the suction valve leakage is noticeable in the compression and expansion modes of the pump. The damage parameter value over 300 cycles is calculated in two ways, considering advance or delay in the opening and closing angles of the discharge valves. The probability density functions of the damage parameter are compared for diagnosis and prognosis on the basis of the probabilistic features of valve leakage.

  7. Estimation of probability density functions of damage parameter for valve leakage detection in reciprocating pump used in nuclear power plants

    International Nuclear Information System (INIS)

    Lee, Jong Kyeom; Kim, Tae Yun; Kim, Hyun Su; Chai, Jang Bom; Lee, Jin Woo

    2016-01-01

    This paper presents an advanced estimation method for obtaining the probability density functions of a damage parameter for valve leakage detection in a reciprocating pump. The estimation method is based on a comparison of model data which are simulated by using a mathematical model, and experimental data which are measured on the inside and outside of the reciprocating pump in operation. The mathematical model, which is simplified and extended on the basis of previous models, describes not only the normal state of the pump, but also its abnormal state caused by valve leakage. The pressure in the cylinder is expressed as a function of the crankshaft angle, and an additional volume flow rate due to the valve leakage is quantified by a damage parameter in the mathematical model. The change in the cylinder pressure profiles due to the suction valve leakage is noticeable in the compression and expansion modes of the pump. The damage parameter value over 300 cycles is calculated in two ways, considering advance or delay in the opening and closing angles of the discharge valves. The probability density functions of the damage parameter are compared for diagnosis and prognosis on the basis of the probabilistic features of valve leakage

  8. Estimation of Probability Density Functions of Damage Parameter for Valve Leakage Detection in Reciprocating Pump Used in Nuclear Power Plants

    Directory of Open Access Journals (Sweden)

    Jong Kyeom Lee

    2016-10-01

    Full Text Available This paper presents an advanced estimation method for obtaining the probability density functions of a damage parameter for valve leakage detection in a reciprocating pump. The estimation method is based on a comparison of model data which are simulated by using a mathematical model, and experimental data which are measured on the inside and outside of the reciprocating pump in operation. The mathematical model, which is simplified and extended on the basis of previous models, describes not only the normal state of the pump, but also its abnormal state caused by valve leakage. The pressure in the cylinder is expressed as a function of the crankshaft angle, and an additional volume flow rate due to the valve leakage is quantified by a damage parameter in the mathematical model. The change in the cylinder pressure profiles due to the suction valve leakage is noticeable in the compression and expansion modes of the pump. The damage parameter value over 300 cycles is calculated in two ways, considering advance or delay in the opening and closing angles of the discharge valves. The probability density functions of the damage parameter are compared for diagnosis and prognosis on the basis of the probabilistic features of valve leakage.

  9. Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage

    International Nuclear Information System (INIS)

    Noda, Taichi; Takahashi, Akihisa; Kondo, Natsuko; Mori, Eiichiro; Okamoto, Noritomo; Nakagawa, Yosuke; Ohnishi, Ken; Zdzienicka, Malgorzata Z.; Thompson, Larry H.; Helleday, Thomas; Asada, Hideo

    2011-01-01

    The role of the Fanconi anemia (FA) repair pathway for DNA damage induced by formaldehyde was examined in the work described here. The following cell types were used: mouse embryonic fibroblast cell lines FANCA -/- , FANCC -/- , FANCA -/- C -/- , FANCD2 -/- and their parental cells, the Chinese hamster cell lines FANCD1 mutant (mt), FANCGmt, their revertant cells, and the corresponding wild-type (wt) cells. Cell survival rates were determined with colony formation assays after formaldehyde treatment. DNA double strand breaks (DSBs) were detected with an immunocytochemical γH2AX-staining assay. Although the sensitivity of FANCA -/- , FANCC -/- and FANCA -/- C -/- cells to formaldehyde was comparable to that of proficient cells, FANCD1mt, FANCGmt and FANCD2 -/- cells were more sensitive to formaldehyde than the corresponding proficient cells. It was found that homologous recombination (HR) repair was induced by formaldehyde. In addition, γH2AX foci in FANCD1mt cells persisted for longer times than in FANCD1wt cells. These findings suggest that formaldehyde-induced DSBs are repaired by HR through the FA repair pathway which is independent of the FA nuclear core complex. -- Research highlights: → We examined to clarify the repair pathways of formaldehyde-induced DNA damage. Formaldehyde induces DNA double strand breaks (DSBs). → DSBs are repaired through the Fanconi anemia (FA) repair pathway. → This pathway is independent of the FA nuclear core complex. → We also found that homologous recombination repair was induced by formaldehyde.

  10. Ddx19 links mRNA nuclear export with progression of transcription and replication and suppresses genomic instability upon DNA damage in proliferating cells.

    Science.gov (United States)

    Hodroj, Dana; Serhal, Kamar; Maiorano, Domenico

    2017-09-03

    The DEAD-box Helicase 19 (Ddx19) gene codes for an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. In unperturbed cells, Ddx19 localizes in the cytoplasm and at the cytoplasmic face of the nuclear pore. Here we review recent findings related to an additional Ddx19 function in the nucleus in resolving RNA:DNA hybrids (R-loops) generated during collision between transcription and replication, and upon DNA damage. Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of the Ddx19 protein from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops, and down regulation of Ddx19 expression induces DNA double strand breaks only in proliferating cells. Overall these observations put forward Ddx19 as an important novel mediator of the crosstalk between transcription and replication.

  11. Damage of reactor recirculation pump of No.3 plant in Fukushima No.2 Nuclear Power Station, Tokyo Electric Power Co., Inc

    International Nuclear Information System (INIS)

    1990-01-01

    No.3 plant in Fukushima No.2 Nuclear Power Station is a BWR plant with the rated output of 1100 MW, and as for the damage of its reactor recirculation pump, the investigation of the cause and the examination of countermeasures are advanced by the special committee. It is presumed that the submerged bearing ring of this pump caused the fatigue fracture due to the insufficient penetration in the fillet-welded part. The ring broke into pieces, and the main disk of the impeller was broken by the wear due to the pieces. Further, the damage of washers and the falling-off of bolts occurred. The metallic particles generated by wear were about 30 kg, and it is presumed that several kg of them adhered to fuel. Hereafter, the investigation of the cause will be continued, and the countermeasures for preventing the recurrence are examined. On January 1, 1989, the vibration of the pump increased, and the alarm was issued. However, the operation was continued carefully. On January 6, the vibration increased again, and on January 7, the reactor was stopped. The third regular inspection was begun on the same day, and the damage of the pump was found. (K.I.)

  12. Damage caused to houses and equipment by underground nuclear explosions; Degats dus aux explosions nucleaires souterraines sur les habitations et les equipements

    Energy Technology Data Exchange (ETDEWEB)

    Delort, F; Guerrini, C [Commissariat a l' Energie Atomique, Bruyeres-le-Chatel (France). Centre d' Etudes

    1969-07-01

    A description is given of the damaged caused to various structures, buildings, houses, mechanical equipment and electrical equipment by underground nuclear explosions in granite. For each type of equipment or building are given the limiting distances for a given degree of damage. These distances have been related to a parameter characterizing the movement of the medium; it is thus possible to generalize the results obtained in granite, for different media. The problem of estimating the damage caused at a greater distance from the explosion is considered. (authors) [French] Les degats sur diverses structures, constructions, habitations, equipements mecaniques et materiels electriques provoques par des explosions nucleaires souterraines dans le granite sont decrits. On a indique pour chaque type de materiel ou de construction, les distances limites correspondant a un degre de gravite de dommage observe. Ces distances ont ete reliees a un parametre caracterisant le mouvement du milieu, permettant ainsi de generaliser les resultats obtenus dans le granite, a differents milieux. Le probleme de la prevision des degats en zone lointaine a ete aborde. (auteurs)

  13. Nuclear abnormalities in cells from nasal epithelium: a promising assay to evaluate DNA damage related to air pollution in infants

    Directory of Open Access Journals (Sweden)

    Michelle Mergener

    2014-12-01

    Full Text Available OBJECTIVES: This study intends to provide a quick, easy, and inexpensive way to assess nuclear abnormalities such as micronuclei and bud frequencies; binucleated, karyorrhectic, karyolytic, pycnotic, and condensed chromatin cells in nasal scrapings of infants, which are particularly important for conducting genotoxic studies related to the inhaled atmosphere in pediatric populations. METHODS: Nasal swab samples were collected from 40 infants under 12 months of age using a small cytobrush. 2,000 cells from each infant sample were analyzed and classified according to the frequency of nuclear abnormalities. RESULTS: Rates of nuclear abnormalities found agree with values reported in other studies of neonates and children. This study found 0.13% of cells with micronuclei; 1.20% karyorrhexis; 0.03% pyknosis; 10.85% karyolysis; 1.11% condensed chromatin; 0.54 binucleated cells; and 0.02% nuclear bud. Differences were not observed between genders or environmental passive smoking, nor was any age correlation found. CONCLUSION: The assay proposed here is suitable for assessing the frequency of nuclear abnormalities from nasal cells in infants.

  14. Fanconi anemia proteins localize to chromatin and the nuclear matrix in a DNA damage- and cell cycle-regulated manner.

    Science.gov (United States)

    Qiao, F; Moss, A; Kupfer, G M

    2001-06-29

    Fanconi anemia (FA) is a genetic disease characterized by congenital defects, bone marrow failure, and cancer susceptibility. Cells from patients with FA exhibit genomic instability and hypersensitivity to DNA cross linking agents such as mitomycin C. Despite the identification of seven complementation groups and the cloning of six genes, the function of the encoded gene products remains elusive. The FancA (Fanconi anemia complementation group A), FancC, and FancG proteins have been detected within a nuclear complex, but no change in level, binding, or localization has been reported as a result of drug treatment or cell cycle. We show that in immunofluorescence studies, FancA appears as a non-nucleolar nuclear protein that is excluded from condensed, mitotic chromosomes. Biochemical fractionation reveals that the FA proteins are found in nuclear matrix and chromatin and that treatment with mitomycin C results in increase of the FA proteins in nuclear matrix and chromatin fractions. This induction occurs in wild-type cells and mutant FA-D (Fanconi complementation group D) cells but not in mutant FA-A cells. Immunoprecipitation of FancA protein in chromatin demonstrates the coprecipitation of FancA, FancC, and FancG, showing that the FA proteins move together as a complex. Also, fractionation of mitotic cells confirms the lack of FA proteins in chromatin or the nuclear matrix. Furthermore, phosphorylation of FancG was found to be temporally correlated with exit of the FA complex from chromosomes at mitosis. Taken together, these findings suggest a role for FA proteins in chromatin and nuclear matrix.

  15. ''Safety rules of fatigue damage for nuclear facilities pressurized equipment at the sizing and the operation stage''

    International Nuclear Information System (INIS)

    Grandemange, J.M.; Faidy, C.

    2001-01-01

    This paper presents the method applied in the nuclear industry in the domain of the fatigue risk safety. It recalls the fatigue curves origins and presents the technical requirements implemented during the design and the construction. It also presents the follow-up of transients in service and the periodical examinations. (A.L.B.)

  16. The usefulness of the nuclear cardiology in the cellular implant in patients with severe myocardial damage; La utilidad de la cardiologia nuclear en el implante celular en pacientes con dano miocardico severo

    Energy Technology Data Exchange (ETDEWEB)

    Omelas A, M.; Arguero S, R.; Garrido G, M.H.; Rodriguez C, A.; Careaga, G.; Castano G, R.; Nambo, M.J.; Pascual P, J.; Ortega R, A.; Gaxiola A, A.; Magana S, J.A.; Estrada A, H.; Equipo de Tecnicos en Medicina Nuclear [Centro Medico Nacional Siglo XXI IMSS Hospital de Cardiologia-Servicio de Medicina Nuclear Mexico DF (Mexico)

    2005-07-01

    The recent therapeutic advances as the cellular implant as well as those different protocols of image acquisition in the field of the Nuclear Cardiology its have allowed that the patient with severe myocardial damage and without some possibility of revascularization is benefited with these advances. Doubtless the Tl-201 par excellence has an important paper for standardize the more appropriate therapeutic behavior for the heart attack patient; reason by this investigation protocol was developed. The objective of the study was to identify the heart attack regions without viable tissue with SPECT in patient with important myocardial damage without some possibility of traditional revascularization; for the 'Stem cell' cellular implantation therapy. The methodology it was carried out by a study of myocardial perfusion in 10 patients with important myocardial damage previous cellular implants, with PICANUC/ SPECT methodology and using a software (Emory Tool Box) for the image processing validated by the University of Emory Atlanta GA; and using as tracer the Tl - 201 to identify the heart attack regions without presence of viable tissue with an analysis model of 17 segments standardized for the left ventricle; qualifying this way the myocardial perfusion in: 0 (normal), 1 (light), 2 (moderate), 3 (severe), 4 (absent) and x (bad technique). The conclusions were that the SPECT study with PICANUC methodology with Tl-201 is safe and effective for the precise localization for the cellular implantation via direct intra myocardial. (Author)

  17. Study by electronic structure calculations of the radiation damage in the UO2 nuclear fuel: behaviour of the point defects and fission gases

    International Nuclear Information System (INIS)

    Vathonne, Emerson

    2014-01-01

    Uranium dioxide (UO 2 ) is worldwide the most widely used fuel in nuclear plants in the world and in particular in pressurized water reactors (PWR). In-pile the fission of uranium nuclei creates fission products and point defects in the fuel. The understanding of the evolution of these radiation damages requires a multi-scale modelling approach of the nuclear fuel, from the scale of the pellet to the atomic scale. We used an electronic structure calculation method based on the density functional theory (DFT) to model radiation damage in UO 2 at the atomic scale. A Hubbard-type Coulomb interaction term is added to the standard DFT formalism to take into account the strong correlations of the 5f electrons in UO 2 . This method is used to study point defects with various charge states and the incorporation and diffusion of krypton in uranium dioxide. This study allowed us to obtain essential data for higher scale models but also to interpret experimental results. In parallel of this study, three ways to improve the state of the art of electronic structure calculations of UO 2 have been explored: the consideration of the spin-orbit coupling neglected in current point defect calculations, the application of functionals allowing one to take into account the non-local interactions such as van der Waals interactions important for rare gases and the use of the Dynamical Mean Field Theory combined to the DFT method in order to take into account the dynamical effects in the 5f electron correlations. (author) [fr

  18. Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage

    Energy Technology Data Exchange (ETDEWEB)

    Noda, Taichi [Department of Biology, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521 (Japan); Department of Dermatology, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521 (Japan); Takahashi, Akihisa [Department of Biology, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521 (Japan); Kondo, Natsuko [Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Kumatori-cho, Sennan-gun, Osaka 590-0494 (Japan); Mori, Eiichiro [Department of Biology, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521 (Japan); Okamoto, Noritomo [Department of Otorhinolaryngology, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521 (Japan); Nakagawa, Yosuke [Department of Oral and Maxillofacial Surgery, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521 (Japan); Ohnishi, Ken [Department of Biology, Ibaraki Prefectual University of Health Sciences, 4669-2 Ami, Ami-mati, Inasiki-gun, Ibaraki 300-0394 (Japan); Zdzienicka, Malgorzata Z. [Department of Molecular Cell Genetics, Collegium Medicum in Bydgoszcz, Nicolaus-Copernicus-University in Torun, ul. Sklodowskiej-Curie 9, 85-094 Bydgoszcz (Poland); Thompson, Larry H. [Biosciences and Biotechnology Division, L452, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, CA 94551-0808 (United States); Helleday, Thomas [Gray Institute for Radiation Oncology and Biology, University of Oxford, Old Road Campus Research Building, Off Roosevelt Drive, Oxford, OX3 7DQ (United Kingdom); Department of Genetics, Microbiology and Toxicology Stockholm University, SE-106 91 Stockholm (Sweden); Asada, Hideo [Department of Dermatology, School of Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521 (Japan); and others

    2011-01-07

    The role of the Fanconi anemia (FA) repair pathway for DNA damage induced by formaldehyde was examined in the work described here. The following cell types were used: mouse embryonic fibroblast cell lines FANCA{sup -/-}, FANCC{sup -/-}, FANCA{sup -/-}C{sup -/-}, FANCD2{sup -/-} and their parental cells, the Chinese hamster cell lines FANCD1 mutant (mt), FANCGmt, their revertant cells, and the corresponding wild-type (wt) cells. Cell survival rates were determined with colony formation assays after formaldehyde treatment. DNA double strand breaks (DSBs) were detected with an immunocytochemical {gamma}H2AX-staining assay. Although the sensitivity of FANCA{sup -/-}, FANCC{sup -/-} and FANCA{sup -/-}C{sup -/-} cells to formaldehyde was comparable to that of proficient cells, FANCD1mt, FANCGmt and FANCD2{sup -/-} cells were more sensitive to formaldehyde than the corresponding proficient cells. It was found that homologous recombination (HR) repair was induced by formaldehyde. In addition, {gamma}H2AX foci in FANCD1mt cells persisted for longer times than in FANCD1wt cells. These findings suggest that formaldehyde-induced DSBs are repaired by HR through the FA repair pathway which is independent of the FA nuclear core complex. -- Research highlights: {yields} We examined to clarify the repair pathways of formaldehyde-induced DNA damage. Formaldehyde induces DNA double strand breaks (DSBs). {yields} DSBs are repaired through the Fanconi anemia (FA) repair pathway. {yields} This pathway is independent of the FA nuclear core complex. {yields} We also found that homologous recombination repair was induced by formaldehyde.

  19. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: The DAMAGE study

    DEFF Research Database (Denmark)

    Reiling, Erwin; van Vliet-Ostaptchouk, Jana V; van 't Riet, Esther

    2009-01-01

    ). After a meta-analysis, only one SNP in SIRT4 (rs2522138) remained significant (P=0.01). Extending the second stage with samples from the Danish Steno Study (n=1220 participants) resulted in a common odds ratio (OR) of 0.92 (0.85-1.00), P=0.06. Moreover, in a large meta-analysis of three genome......Mitochondria play an important role in many processes, like glucose metabolism, fatty acid oxidation and ATP synthesis. In this study, we aimed to identify association of common polymorphisms in nuclear-encoded genes involved in mitochondrial protein synthesis and biogenesis with type II diabetes...

  20. Protective Role of Nuclear Factor E2-Related Factor 2 against Acute Oxidative Stress-Induced Pancreatic β-Cell Damage

    Directory of Open Access Journals (Sweden)

    Jingqi Fu

    2015-01-01

    Full Text Available Oxidative stress is implicated in the pathogenesis of pancreatic β-cell dysfunction that occurs in both type 1 and type 2 diabetes. Nuclear factor E2-related factor 2 (NRF2 is a master regulator in the cellular adaptive response to oxidative stress. The present study found that MIN6 β-cells with stable knockdown of Nrf2 (Nrf2-KD and islets isolated from Nrf2-knockout mice expressed substantially reduced levels of antioxidant enzymes in response to a variety of stressors. In scramble MIN6 cells or wild-type islets, acute exposure to oxidative stressors, including hydrogen peroxide (H2O2 and S-nitroso-N-acetylpenicillamine, resulted in cell damage as determined by decrease in cell viability, reduced ATP content, morphology changes of islets, and/or alterations of apoptotic biomarkers in a concentration- and/or time-dependent manner. In contrast, silencing of Nrf2 sensitized MIN6 cells or islets to the damage. In addition, pretreatment of MIN6 β-cells with NRF2 activators, including CDDO-Im, dimethyl fumarate (DMF, and tert-butylhydroquinone (tBHQ, protected the cells from high levels of H2O2-induced cell damage. Given that reactive oxygen species (ROS are involved in regulating glucose-stimulated insulin secretion (GSIS and persistent activation of NRF2 blunts glucose-triggered ROS signaling and GSIS, the present study highlights the distinct roles that NRF2 may play in pancreatic β-cell dysfunction that occurs in different stages of diabetes.

  1. Probabilistic modelling of the damage of geological barriers of the nuclear waste deep storage - ENDOSTON project, final report

    International Nuclear Information System (INIS)

    2010-01-01

    As the corrosion of metallic casings of radioactive waste storage packages releases hydrogen under pressure, and as the overpressure disturbs the stress fields, the authors report the development of methodologies and numerical simulation tools aimed at a better understanding of the mechanisms of development and propagation of crack networks in the geological barrier due to this overpressure. They present a probabilistic model of the formation of crack networks in rocks, with the probabilistic post-processing of a finite element calculation. They describe the modelling of crack propagation and damage in quasi-brittle materials. They present the ENDO-HETEROGENE model for the formation and propagation of cracks in heterogeneous media, describe the integration of the model into the Aster code, and report the model validation (calculation of the stress intensity factor, grid dependence). They finally report a test case of the ENDO-HETEROGENE model

  2. Whole thorax irradiation of non-human primates induces persistent nuclear damage and gene expression changes in peripheral blood cells.

    Directory of Open Access Journals (Sweden)

    Shanaz A Ghandhi

    Full Text Available We investigated the cytogenetic and gene expression responses of peripheral blood cells of non-human primates (NHP, Macaca mulatta that were whole-thorax irradiated with a single dose of 10 Gy. In this model, partial irradiation of NHPs in the thoracic region (Whole Thorax Lung Irradiation, WTLI allows the study of late radiation-induced lung injury, while avoiding acute radiation syndromes related to hematopoietic and gastrointestinal injury. A transient drop in circulating lymphocytes and platelets was seen by 9 days, followed by elevations in respiratory rate, circulating neutrophils, lymphocytes, and monocytes at 60-100 days, corresponding to computed tomography (CT and histologic evidence of pneumonitis, and elective euthanasia of four animals. To evaluate long-term DNA damage in NHP peripheral blood lymphocytes after 10 Gy WTLI, we used the cytokinesis-block micronucleus (CBMN assay to measure chromosomal aberrations as post-mitotic micronuclei in blood samples collected up to 8 months after irradiation. Regression analysis showed significant induction of micronuclei in NHP blood cells that persisted with a gradual decline over the 8-month study period, suggesting long-term DNA damage in blood lymphocytes after WTLI. We also report transcriptomic changes in blood up to 30 days after WTLI. We isolated total RNA from peripheral blood at 3 days before and then at 2, 5 and 30 days after irradiation. We identified 1187 transcripts that were significantly changed across the 30-day time course. From changes in gene expression, we identified biological processes related to immune responses, which persisted across the 30-day study. Response to oxygen-containing compounds and bacteria were implicated by gene-expression changes at the earliest day 2 and latest, day 30 time-points. Gene expression changes suggest a persistent altered state of the immune system, specifically response to infection, for at least a month after WTLI.

  3. Whole thorax irradiation of non-human primates induces persistent nuclear damage and gene expression changes in peripheral blood cells.

    Science.gov (United States)

    Ghandhi, Shanaz A; Turner, Helen C; Shuryak, Igor; Dugan, Gregory O; Bourland, J Daniel; Olson, John D; Tooze, Janet A; Morton, Shad R; Batinic-Haberle, Ines; Cline, J Mark; Amundson, Sally A

    2018-01-01

    We investigated the cytogenetic and gene expression responses of peripheral blood cells of non-human primates (NHP, Macaca mulatta) that were whole-thorax irradiated with a single dose of 10 Gy. In this model, partial irradiation of NHPs in the thoracic region (Whole Thorax Lung Irradiation, WTLI) allows the study of late radiation-induced lung injury, while avoiding acute radiation syndromes related to hematopoietic and gastrointestinal injury. A transient drop in circulating lymphocytes and platelets was seen by 9 days, followed by elevations in respiratory rate, circulating neutrophils, lymphocytes, and monocytes at 60-100 days, corresponding to computed tomography (CT) and histologic evidence of pneumonitis, and elective euthanasia of four animals. To evaluate long-term DNA damage in NHP peripheral blood lymphocytes after 10 Gy WTLI, we used the cytokinesis-block micronucleus (CBMN) assay to measure chromosomal aberrations as post-mitotic micronuclei in blood samples collected up to 8 months after irradiation. Regression analysis showed significant induction of micronuclei in NHP blood cells that persisted with a gradual decline over the 8-month study period, suggesting long-term DNA damage in blood lymphocytes after WTLI. We also report transcriptomic changes in blood up to 30 days after WTLI. We isolated total RNA from peripheral blood at 3 days before and then at 2, 5 and 30 days after irradiation. We identified 1187 transcripts that were significantly changed across the 30-day time course. From changes in gene expression, we identified biological processes related to immune responses, which persisted across the 30-day study. Response to oxygen-containing compounds and bacteria were implicated by gene-expression changes at the earliest day 2 and latest, day 30 time-points. Gene expression changes suggest a persistent altered state of the immune system, specifically response to infection, for at least a month after WTLI.

  4. Irradiation damage

    Energy Technology Data Exchange (ETDEWEB)

    Howe, L.M

    2000-07-01

    There is considerable interest in irradiation effects in intermetallic compounds from both the applied and fundamental aspects. Initially, this interest was associated mainly with nuclear reactor programs but it now extends to the fields of ion-beam modification of metals, behaviour of amorphous materials, ion-beam processing of electronic materials, and ion-beam simulations of various kinds. The field of irradiation damage in intermetallic compounds is rapidly expanding, and no attempt will be made in this chapter to cover all of the various aspects. Instead, attention will be focused on some specific areas and, hopefully, through these, some insight will be given into the physical processes involved, the present state of our knowledge, and the challenge of obtaining more comprehensive understanding in the future. The specific areas that will be covered are: point defects in intermetallic compounds; irradiation-enhanced ordering and irradiation-induced disordering of ordered alloys; irradiation-induced amorphization.

  5. Irradiation damage

    International Nuclear Information System (INIS)

    Howe, L.M.

    2000-01-01

    There is considerable interest in irradiation effects in intermetallic compounds from both the applied and fundamental aspects. Initially, this interest was associated mainly with nuclear reactor programs but it now extends to the fields of ion-beam modification of metals, behaviour of amorphous materials, ion-beam processing of electronic materials, and ion-beam simulations of various kinds. The field of irradiation damage in intermetallic compounds is rapidly expanding, and no attempt will be made in this chapter to cover all of the various aspects. Instead, attention will be focused on some specific areas and, hopefully, through these, some insight will be given into the physical processes involved, the present state of our knowledge, and the challenge of obtaining more comprehensive understanding in the future. The specific areas that will be covered are: point defects in intermetallic compounds; irradiation-enhanced ordering and irradiation-induced disordering of ordered alloys; irradiation-induced amorphization

  6. Damage dosimetry and embrittlement monitoring of nuclear pressure vessels in real time by magnetic properties measurement. Final report

    International Nuclear Information System (INIS)

    Ougouag, A.M.; Stubbins, J.F.; Williams, J.F.; Shong, Wei-Ja.

    1995-04-01

    This program developed a nondestructive technique for gauging the progress of embrittlement of nuclear pressure vessel steels (PVS) by means of monitoring radiation-induced changes in magnetic properties. The technique was developed by running a series of experiments in reactor on typical nuclear pressure vessel steels and weldment material. Following irradiation, changes in magnetic properties were measured and correlated with irradiation dose and with mechanical properties changes, where possible. The changes in magnetic properties were unique to the irradiation environment, and were much larger than those produce by thermal aging in the absence of irradiation. Special techniques for magnetic properties change measurement were developed and complimented by more standard magnetic properties measurement techniques including SQUID measurements. The results of the experiments revealed that magnetic properties were very sensitive to irradiation. Changes in microstructurally-related magnetic properties of as much as 40% were noted after irradiation exposure of as little as 10 17 n/cm 2 (E > 0.1 MeV). The magnetic properties changes plateaued out after doses of around as 10 18 n/cm 2 (E > 0.1 MeV). It is unclear whether further changes would be noted at higher doses which would also be useful for tracking the embrittlement phenomenon. This is recommended for further study. The work supported here resulted in several publications in the open scientific literature

  7. Biological Sexing of a 4000-Year-Old Egyptian Mummy Head to Assess the Potential of Nuclear DNA Recovery from the Most Damaged and Limited Forensic Specimens.

    Science.gov (United States)

    Loreille, Odile; Ratnayake, Shashikala; Bazinet, Adam L; Stockwell, Timothy B; Sommer, Daniel D; Rohland, Nadin; Mallick, Swapan; Johnson, Philip L F; Skoglund, Pontus; Onorato, Anthony J; Bergman, Nicholas H; Reich, David; Irwin, Jodi A

    2018-03-01

    High throughput sequencing (HTS) has been used for a number of years in the field of paleogenomics to facilitate the recovery of small DNA fragments from ancient specimens. Recently, these techniques have also been applied in forensics, where they have been used for the recovery of mitochondrial DNA sequences from samples where traditional PCR-based assays fail because of the very short length of endogenous DNA molecules. Here, we describe the biological sexing of a ~4000-year-old Egyptian mummy using shotgun sequencing and two established methods of biological sex determination (R X and R Y ), by way of mitochondrial genome analysis as a means of sequence data authentication. This particular case of historical interest increases the potential utility of HTS techniques for forensic purposes by demonstrating that data from the more discriminatory nuclear genome can be recovered from the most damaged specimens, even in cases where mitochondrial DNA cannot be recovered with current PCR-based forensic technologies. Although additional work remains to be done before nuclear DNA recovered via these methods can be used routinely in operational casework for individual identification purposes, these results indicate substantial promise for the retrieval of probative individually identifying DNA data from the most limited and degraded forensic specimens.

  8. Biological Sexing of a 4000-Year-Old Egyptian Mummy Head to Assess the Potential of Nuclear DNA Recovery from the Most Damaged and Limited Forensic Specimens

    Directory of Open Access Journals (Sweden)

    Odile Loreille

    2018-03-01

    Full Text Available High throughput sequencing (HTS has been used for a number of years in the field of paleogenomics to facilitate the recovery of small DNA fragments from ancient specimens. Recently, these techniques have also been applied in forensics, where they have been used for the recovery of mitochondrial DNA sequences from samples where traditional PCR-based assays fail because of the very short length of endogenous DNA molecules. Here, we describe the biological sexing of a ~4000-year-old Egyptian mummy using shotgun sequencing and two established methods of biological sex determination (RX and RY, by way of mitochondrial genome analysis as a means of sequence data authentication. This particular case of historical interest increases the potential utility of HTS techniques for forensic purposes by demonstrating that data from the more discriminatory nuclear genome can be recovered from the most damaged specimens, even in cases where mitochondrial DNA cannot be recovered with current PCR-based forensic technologies. Although additional work remains to be done before nuclear DNA recovered via these methods can be used routinely in operational casework for individual identification purposes, these results indicate substantial promise for the retrieval of probative individually identifying DNA data from the most limited and degraded forensic specimens.

  9. Liver damages and nuclear abnormalities in erythrocytes of Atherinella brasiliensis (Actynopterigii, Atherinopsidade from two beaches in Southeast of Brazil

    Directory of Open Access Journals (Sweden)

    Welingtom S. Fernandez

    2011-06-01

    Full Text Available There are few environmental studies using biomarkers for the species Atherinella brasiliensis in Brazil. In the present work, the presence of hepatic histopathological lesions and nuclear abnormalities in erythrocytes were investigated in A. brasiliensis from Lamberto, a beach under influence of domestic wastes and marine activities. For comparison, fish were also sampled in Puruba, a non-polluted beach, located in the northeastern of São Paulo State. The frequency of lesions found in liver was in higher numbers in individuals from Lamberto than Puruba beach. The most critical injuries observed in A. brasiliensis were the presence of necrotic areas, leucocytes infiltration and piknotic nucleus. A high occurrence of cells with vacuolization was also observed. The hepatic lesion index of the fish from Lamberto beach showed significant high values (Iorg=13 when compared with fish from Puruba beach (Iorg=7 suggesting the influence of the several human activities in the studied site. Notched and blebed nucleous were observed in this study, and significant differences were found between the studied sites. However, these differences did not reflect the total nuclear alterations.Existem poucos estudos no Brasil usando biomarcadores em Atherinella brasiliensis. No presente trabalho foram investigadas a presença de lesões histopatológicas hepáticas e as alterações nucleares em eritrócitos de A. brasiliensis amostrados na praia do Lamberto, local submetido à influência de resíduos domésticos e atividades humanas. Para comparação, indivíduos da espécie foram também amostrados na praia de Puruba, local não impactado, localizado no noroeste do estado de São Paulo. Peixes provenientes da praia do Lamberto apresentaram lesões hepáticas em número maior do que aqueles da praia de Puruba. Áreas necróticas, infiltração de leucócitos e núcleos picnóticos foram os danos de maior importância observados em A. brasiliensis, apesar de uma

  10. Grain boundary sweeping and liquefaction-induced fission product behavior in nuclear fuel under severe-core damage accident conditions

    International Nuclear Information System (INIS)

    Rest, J.

    1984-05-01

    The theoretical FASTGRASS-VFP model has been used in the interpretation of fission gas, iodine, tellurium, and cesium release from: (1) irradiated high-burnup LWR fuel in a flowing steam atmosphere during high-temperature, in-cell heating tests performed at Oak Ridge National Laboratory; and (2) trace-irradiated and high-burnup LWR fuel during severe-fuel-damage (SFD) tests performed in the PBF reactor in Idaho. A theory of grain boundary sweeping of gas bubbles, gas bubble behavior during fuel liquefaction (destruction of grain boundaries due to formation of a U-rich melt phase), and U-Zr eutectic melting has been included within the FASTGRASS-VFP formalism. Results of the analyses demonstrate that intragranular fission product behavior during both types of tests can be interpreted in terms of a grain-growth/grain-boundary-sweeping mechanism that enhances the flow of fission products from within the grains to the grain boundaries. Whereas fuel liquefaction leads to an enhanced release of fission products in trace-irradiated fuel, the occurrence of fuel liquefaction in high-burnup fuel can degrade fission product release. This phenomenon is due in part to reduced gas-bubble mobilities in a viscous medium as compared to vapor transport, and in part to a degradation of grain growth rates and the subsequent decrease in grain-boundary sweeping of intragranular fission products into the liquefied lamina. The analysis shows that total UO 2 dissolution due to eutectic melting leads to increased release for both trace-irradiated and high-burnup fuel. The FASTGRASS-VFP predictions, measured release rates from the above tests, and previously published release rates are compared and differences between fission product behavior in trace-irradiated and in high-burnup fuel are highlighted

  11. An integrated approach to the probabilistic assessments of aircraft strikes and structural mode of damages to nuclear power plants

    International Nuclear Information System (INIS)

    Godbout, P.; Brais, A.

    1975-01-01

    The possibilities of an aircraft striking a Canadian nuclear power plant in the vicinity of an airport and of inducing structural failure modes have been evaluated. This evaluation, together with other studies, may enhance decisions in the development of general criteria for the siting of reactors near airports. The study made use, for assessment, of the probabilistic approach and made judicious applications of the finite Canadian, French, German, American and English resources that were available. The tools, techniques and methods used for achieving the above, form what may be called an integrated approach. This method of approach requires that the study be made in six consecutive steps as follows: the qualitative evaluation of having an aircraft strike on a site situated near an airport with the use of the logic model technique; the statistical data gathering on aircraft movements and accidents; evaluating the probability distribution and calculating the basic event probabilities; evaluating the probability of an aircraft strike and the application of the sensitivity approach; generating the probability density distribution versus strike impact energy, that is, the evaluation of the energy envelope; and the probabilistic evaluation of structural failure mode inducements

  12. Nuclear

    International Nuclear Information System (INIS)

    2014-01-01

    This document proposes a presentation and discussion of the main notions, issues, principles, or characteristics related to nuclear energy: radioactivity (presence in the environment, explanation, measurement, periods and activities, low doses, applications), fuel cycle (front end, mining and ore concentration, refining and conversion, fuel fabrication, in the reactor, back end with reprocessing and recycling, transport), the future of the thorium-based fuel cycle (motivations, benefits and drawbacks), nuclear reactors (principles of fission reactors, reactor types, PWR reactors, BWR, heavy-water reactor, high temperature reactor of HTR, future reactors), nuclear wastes (classification, packaging and storage, legal aspects, vitrification, choice of a deep storage option, quantities and costs, foreign practices), radioactive releases of nuclear installations (main released radio-elements, radioactive releases by nuclear reactors and by La Hague plant, gaseous and liquid effluents, impact of releases, regulation), the OSPAR Convention, management and safety of nuclear activities (from control to quality insurance, to quality management and to sustainable development), national safety bodies (mission, means, organisation and activities of ASN, IRSN, HCTISN), international bodies, nuclear and medicine (applications of radioactivity, medical imagery, radiotherapy, doses in nuclear medicine, implementation, the accident in Epinal), nuclear and R and D (past R and D programmes and expenses, main actors in France and present funding, main R and D axis, international cooperation)

  13. Proliferating Cell Nuclear Antigen-dependent Rapid Recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged Sites after UV Irradiation in HeLa Cells*

    Science.gov (United States)

    Ishii, Takashi; Shiomi, Yasushi; Takami, Toshihiro; Murakami, Yusuke; Ohnishi, Naho; Nishitani, Hideo

    2010-01-01

    The licensing factor Cdt1 is degraded by CRL4Cdt2 ubiquitin ligase dependent on proliferating cell nuclear antigen (PCNA) during S phase and when DNA damage is induced in G1 phase. Association of both Cdt2 and PCNA with chromatin was observed in S phase and after UV irradiation. Here we used a micropore UV irradiation assay to examine Cdt2 accumulation at cyclobutane pyrimidine dimer-containing DNA-damaged sites in the process of Cdt1 degradation in HeLa cells. Cdt2, present in the nucleus throughout the cell cycle, accumulated rapidly at damaged DNA sites during G1 phase. The recruitment of Cdt2 is dependent on prior PCNA chromatin binding because Cdt2 association was prevented when PCNA was silenced. Cdt1 was also recruited to damaged sites soon after UV irradiation through its PIP-box. As Cdt1 was degraded, the Cdt2 signal at damaged sites was reduced, but PCNA, cyclobutane pyrimidine dimer, and XPA (xeroderma pigmentosum, complementation group A) signals remained at the same levels. These findings suggest that Cdt1 degradation following UV irradiation occurs rapidly at damaged sites due to PCNA chromatin loading and the recruitment of Cdt1 and CRL4Cdt2, before DNA damage repair is completed. PMID:20929861

  14. Improved estimates of separation distances to prevent unacceptable damage to nuclear power plant structures from hydrogen detonation for gaseous hydrogen storage. Technical report

    International Nuclear Information System (INIS)

    1994-05-01

    This report provides new estimates of separation distances for nuclear power plant gaseous hydrogen storage facilities. Unacceptable damage to plant structures from hydrogen detonations will be prevented by having hydrogen storage facilities meet separation distance criteria recommended in this report. The revised standoff distances are based on improved calculations on hydrogen gas cloud detonations and structural analysis of reinforced concrete structures. Also, the results presented in this study do not depend upon equivalencing a hydrogen detonation to an equivalent TNT detonation. The static and stagnation pressures, wave velocity, and the shock wave impulse delivered to wall surfaces were computed for several different size hydrogen explosions. Separation distance equations were developed and were used to compute the minimum separation distance for six different wall cases and for seven detonating volumes (from 1.59 to 79.67 lbm of hydrogen). These improved calculation results were compared to previous calculations. The ratio between the separation distance predicted in this report versus that predicted for hydrogen detonation in previous calculations varies from 0 to approximately 4. Thus, the separation distances results from the previous calculations can be either overconservative or unconservative depending upon the set of hydrogen detonation parameters that are used. Consequently, it is concluded that the hydrogen-to-TNT detonation equivalency utilized in previous calculations should no longer be used

  15. Korea act on compensation for nuclear damage (as amended on 16 January 2001). Norway act on radiation protection and use of radiation (12 May 2000). Poland atomic energy act (29 November 2000)

    International Nuclear Information System (INIS)

    2001-01-01

    This volume reprints the English and French translation of three nuclear laws. The first law concerns Korea and its purpose is to protect victims and to contribute to the sound development of the nuclear industry by establishing matters relating to compensation in the event of nuclear damage arising during the operation of a nuclear reactor. The second law concerns Norway and its purpose is to prevent the harmful effects of radiation on human health and to contribute to the protection of the environment. It applies to any production, import, export, transport, transfer, possession, installation, use, handling and waste management of radiation sources. It applies also to human activities which causes increased levels of naturally-occurring ionizing radiation in the environment, and to planning and emergency preparedness against incidents and accidents. The last law is the atomic energy act of Poland. It defines the activities related to the peaceful use of atomic energy, involving real and potential exposures to ionizing radiation emitted by artificial radioactive sources, nuclear materials, devices generating ionizing radiation, radioactive waste and spent fuel. It defines also duties of the head of the organisational entity conducting these activities, the authorities competent in the area of nuclear safety and radiological protection, and the principles of third party liability for nuclear damage. The act also establishes financial penalties for the violation of nuclear regulations and the rules for imposing such penalties. It applies also to practices conducted in conditions of exposure to natural ionizing radiation enhanced by human activity. Finally, it defines the principles of radioactive contamination monitoring and establishes rules governing activities undertaken in the event of a radiological emergency as well as in chronic exposure conditions in the aftermath of a radiological emergency or a past practice

  16. Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage

    International Nuclear Information System (INIS)

    Yang, Bei; Fu, Jingqi; Zheng, Hongzhi; Xue, Peng; Yarborough, Kathy; Woods, Courtney G.; Hou, Yongyong; Zhang, Qiang; Andersen, Melvin E.; Pi, Jingbo

    2012-01-01

    Chronic human exposure to inorganic arsenic (iAs), a potent environmental oxidative stressor, is associated with increased prevalence of type 2 diabetes, where impairment of pancreatic β-cell function is a key pathogenic factor. Nuclear factor E2-related factor 2 (Nrf2) is a central transcription factor regulating cellular adaptive response to oxidative stress. However, persistent activation of Nrf2 in response to chronic oxidative stress, including inorganic arsenite (iAs 3+ ) exposure, blunts glucose-triggered reactive oxygen species (ROS) signaling and impairs glucose-stimulated insulin secretion (GSIS). In the current study, we found that MIN6 pancreatic β-cells with stable knockdown of Nrf2 (Nrf2-KD) by lentiviral shRNA and pancreatic islets isolated from Nrf2-knockout (Nrf2−/−) mice exhibited reduced expression of several antioxidant and detoxification enzymes in response to acute iAs 3+ exposure. As a result, Nrf2-KD MIN6 cells and Nrf2−/− islets were more susceptible to iAs 3+ and monomethylarsonous acid (MMA 3+ )-induced cell damage, as measured by decreased cell viability, augmented apoptosis and morphological change. Pretreatment of MIN6 cells with Nrf2 activator tert-butylhydroquinone protected the cells from iAs 3+ -induced cell damage in an Nrf2-dependent fashion. In contrast, antioxidant N‐acetyl cysteine protected Nrf2-KD MIN6 cells against acute cytotoxicity of iAs 3+ . The present study demonstrates that Nrf2-mediated antioxidant response is critical in the pancreatic β-cell defense mechanism against acute cytotoxicity by arsenic. The findings here, combined with our previous results on the inhibitory effect of antioxidants on ROS signaling and GSIS, suggest that Nrf2 plays paradoxical roles in pancreatic β-cell dysfunction induced by environmental arsenic exposure. -- Highlights: ► Lack of Nrf2 reduced expression of antioxidant genes induced by iAs 3+ in β-cells. ► Deficiency of Nrf2 in β-cells sensitized to iAs 3+ and MMA 3

  17. Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Bei [Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709 (United States); Department of Histology and Embryology, College of Basic Medical Sciences, China Medical University, Shenyang 110001 (China); Fu, Jingqi; Zheng, Hongzhi; Xue, Peng; Yarborough, Kathy; Woods, Courtney G.; Hou, Yongyong; Zhang, Qiang; Andersen, Melvin E. [Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709 (United States); Pi, Jingbo, E-mail: jpi@thehamner.org [Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709 (United States)

    2012-11-01

    Chronic human exposure to inorganic arsenic (iAs), a potent environmental oxidative stressor, is associated with increased prevalence of type 2 diabetes, where impairment of pancreatic β-cell function is a key pathogenic factor. Nuclear factor E2-related factor 2 (Nrf2) is a central transcription factor regulating cellular adaptive response to oxidative stress. However, persistent activation of Nrf2 in response to chronic oxidative stress, including inorganic arsenite (iAs{sup 3+}) exposure, blunts glucose-triggered reactive oxygen species (ROS) signaling and impairs glucose-stimulated insulin secretion (GSIS). In the current study, we found that MIN6 pancreatic β-cells with stable knockdown of Nrf2 (Nrf2-KD) by lentiviral shRNA and pancreatic islets isolated from Nrf2-knockout (Nrf2−/−) mice exhibited reduced expression of several antioxidant and detoxification enzymes in response to acute iAs{sup 3+} exposure. As a result, Nrf2-KD MIN6 cells and Nrf2−/− islets were more susceptible to iAs{sup 3+} and monomethylarsonous acid (MMA{sup 3+})-induced cell damage, as measured by decreased cell viability, augmented apoptosis and morphological change. Pretreatment of MIN6 cells with Nrf2 activator tert-butylhydroquinone protected the cells from iAs{sup 3+}-induced cell damage in an Nrf2-dependent fashion. In contrast, antioxidant N‐acetyl cysteine protected Nrf2-KD MIN6 cells against acute cytotoxicity of iAs{sup 3+}. The present study demonstrates that Nrf2-mediated antioxidant response is critical in the pancreatic β-cell defense mechanism against acute cytotoxicity by arsenic. The findings here, combined with our previous results on the inhibitory effect of antioxidants on ROS signaling and GSIS, suggest that Nrf2 plays paradoxical roles in pancreatic β-cell dysfunction induced by environmental arsenic exposure. -- Highlights: ► Lack of Nrf2 reduced expression of antioxidant genes induced by iAs{sup 3+} in β-cells. ► Deficiency of Nrf2 in

  18. Report realized on behalf of the Commission of the Foreign Affairs on the law project, adopted by the Senate, authorizing the approbation of the agreement between the French Republic Government and the Russian Federation Government relative to the civil liability concerning the nuclear damages occurring from the providing of goods devoted to nuclear installations in Russian Federation and coming from the French Republic

    International Nuclear Information System (INIS)

    Andre, R.

    2003-01-01

    In the framework of the civil liability concerning the nuclear damages occurring from the providing of goods devoted to the russian installations, this document presents the international cooperation between the France and the russian institutes and administrations. The objective of this document is to supply a juridical framework concerning the goods realized in Russia by France. The cooperation field with Russia is wide. Nevertheless, it concerns in first part, the 190 nuclear submarine dismantling. (A.L.B.)

  19. Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response.

    Science.gov (United States)

    Low, Ley-Hian; Chow, Yuh-Lit; Li, Yijia; Goh, Choo-Peng; Putz, Ulrich; Silke, John; Ouchi, Toru; Howitt, Jason; Tan, Seong-Seng

    2015-03-13

    During injury, cells are vulnerable to apoptosis from a variety of stress conditions including DNA damage causing double-stranded breaks. Without repair, these breaks lead to aberrations in DNA replication and transcription, leading to apoptosis. A major response to DNA damage is provided by the protein kinase ATM (ataxia telangiectasia mutated) that is capable of commanding a plethora of signaling networks for DNA repair, cell cycle arrest, and even apoptosis. A key element in the DNA damage response is the mobilization of activating proteins into the cell nucleus to repair damaged DNA. BRAT1 is one of these proteins, and it functions as an activator of ATM by maintaining its phosphorylated status while also keeping other phosphatases at bay. However, it is unknown how BRAT1 is trafficked into the cell nucleus to maintain ATM phosphorylation. Here we demonstrate that Ndfip1-mediated ubiquitination of BRAT1 leads to BRAT1 trafficking into the cell nucleus. Without Ndfip1, BRAT1 failed to translocate to the nucleus. Under genotoxic stress, cells showed increased expression of both Ndfip1 and phosphorylated ATM. Following brain injury, neurons show increased expression of Ndfip1 and nuclear translocation of BRAT1. These results point to Ndfip1 as a sensor protein during cell injury and Ndfip1 up-regulation as a cue for BRAT1 ubiquitination by Nedd4 E3 ligases, followed by nuclear translocation of BRAT1. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  20. Nuclear

    International Nuclear Information System (INIS)

    Anon.

    2000-01-01

    The first text deals with a new circular concerning the collect of the medicine radioactive wastes, containing radium. This campaign wants to incite people to let go their radioactive wastes (needles, tubes) in order to suppress any danger. The second text presents a decree of the 31 december 1999, relative to the limitations of noise and external risks resulting from the nuclear facilities exploitation: noise, atmospheric pollution, water pollution, wastes management and fire prevention. (A.L.B.)

  1. Earthquake damage to underground facilities

    International Nuclear Information System (INIS)

    Pratt, H.R.; Hustrulid, W.A.; Stephenson, D.E.

    1978-11-01

    The potential seismic risk for an underground nuclear waste repository will be one of the considerations in evaluating its ultimate location. However, the risk to subsurface facilities cannot be judged by applying intensity ratings derived from the surface effects of an earthquake. A literature review and analysis were performed to document the damage and non-damage due to earthquakes to underground facilities. Damage from earthquakes to tunnels, s, and wells and damage (rock bursts) from mining operations were investigated. Damage from documented nuclear events was also included in the study where applicable. There are very few data on damage in the subsurface due to earthquakes. This fact itself attests to the lessened effect of earthquakes in the subsurface because mines exist in areas where strong earthquakes have done extensive surface damage. More damage is reported in shallow tunnels near the surface than in deep mines. In mines and tunnels, large displacements occur primarily along pre-existing faults and fractures or at the surface entrance to these facilities.Data indicate vertical structures such as wells and shafts are less susceptible to damage than surface facilities. More analysis is required before seismic criteria can be formulated for the siting of a nuclear waste repository

  2. Estimated airborne release of plutonium from Atomics International's Nuclear Materials Development Facility in the Santa Susana site, California, as a result of postulated damage from severe wind and earthquake hazard

    International Nuclear Information System (INIS)

    Mishima, J.; Ayer, J.E.

    1981-09-01

    The potential mass of airborne releases of plutonium (source term) that could result from wind and seismic damage is estimated for the Atomics International Company's Nuclear Materials Development Facility (NMDF) at the Santa Susana site in California. The postulated source terms will be useful as the basis for estimating the potential dose to the maximum exposed individual by inhalation and to the total population living within a prescribed radius of the site. The respirable fraction of airborne particles is thus the principal concern. The estimated source terms are based on the damage ratio, and the potential airborne releases if all enclosures suffer particular levels of damage. In an attempt to provide a realistic range of potential source terms that include most of the normal processing conditions, a best estimate bounded by upper and lower limits is provided. The range of source terms is calculated by combining a high best estimate and a low damage ratio, based on a fraction of enclosures suffering crush or perforation, with the airborne release from enclosures based upon an upper limit, average, and lower limit inventory of dispersible materials at risk. Two throughput levels are considered. The factors used to evaluate the fractional airborne release of materials and the exchange rates between enclosed and exterior atmospheres are discussed. The postulated damage and source terms are discussed for wind and earthquake hazard scenarios in order of their increasing severity

  3. Seguro Nuclear

    International Nuclear Information System (INIS)

    Oliveira, S.C.C. de.

    1978-04-01

    A description of the constitutive elements of insurance and its features in the field of law, and special legislation about the matter are given. The relationship between the liability of the nuclear power plant operator and the international conventions about civil liability on nuclear damage is discussed. Some considerations on damage reparing in the United States, Germany, France and Spain are presented. (A.L.S.L.) [pt

  4. Vienna convention on civil liability for nuclear damage and optional protocol concerning the compulsory settlement of disputes. Status lists as of 12 September 2000. Signature, ratification, accession, or succession. Declarations/reservations made upon expressing consent to be bound and objections thereto. Declarations/reservations made upon signature

    International Nuclear Information System (INIS)

    2000-01-01

    The document provides the status list to the Protocol to Amend the Vienna Convention on Civil Liability for Nuclear Damage and optional protocol concerning the compulsory settlement of disputes as of 12 September 2000

  5. Radiation-induced damage of membranes

    International Nuclear Information System (INIS)

    Yonei, Shuji

    1977-01-01

    An outline of membranous structure was stated, and radiation-induced damage of membranes were surveyed. By irradiation, permeability of membranes, especially passive transportation mechanism, was damaged, and glycoprotein in the surface layers of cells and the surface layer structures were changed. The intramembranous damage was induced by decrease of electrophoresis of nuclear mambranes and a quantitative change of cytochrome P450 of microsomal membranes of the liver, and peroxidation of membranous lipid and SH substitute damage of membranous protein were mentioned as the mechanism of membranous damage. Recovery of membranous damage depends on radiation dose and temperature, and membranous damage participates largely in proliferation death. (tsunoda, M.)

  6. Analysis of the micro-structural damages by neutronic irradiation of the steel of reactor vessels of the nuclear power plant of Laguna Verde. Characterization of the design steel

    International Nuclear Information System (INIS)

    Moranchel y Rodriguez, M.; Garcia B, A.; Longoria G, L. C.

    2010-09-01

    The vessel of a nuclear reactor is one of the safety barriers more important in the design, construction and operation of the reactor. If the vessel results affected to the grade of to have fracture and/or cracks it is very probable the conclusion of their useful life in order to guarantee the nuclear safety and the radiological protection of the exposure occupational personnel, of the public and the environment avoiding the exposition to radioactive sources. The materials of the vessel of a nuclear reactor are exposed continually to the neutronic irradiation that generates the same nuclear reactor. The neutrons that impact to the vessel have the sufficient energy to penetrate certain depth in function of the energy of the incident neutron until reaching the repose or to be absorbed by some nucleus. In the course of their penetration, the neutrons interact with the nuclei, atoms, molecules and with the same crystalline nets of the vessel material producing vacuums, interstitial, precipitate and segregations among other defects that can modify the mechanical properties of the steel. The steel A533-B is the material with which is manufactured the vessel of the nuclear reactors of nuclear power plant of Laguna Verde, is an alloy that, among other components, it contains atoms of Ni that if they are segregated by the neutrons impact this would favor to the cracking of the same vessel. This work is part of an investigation to analyze the micro-structural damages of the reactor vessels of the nuclear power plant of Laguna Verde due to the neutronic irradiation which is exposed in a continuous way. We will show the characterization of the design steel of the vessel, what offers a comprehension about their chemical composition, the superficial topography and the crystalline nets of the steel A533-B. It will also allow analyze the existence of precipitates, segregates, the type of crystalline net and the distances inter-plains of the design steel of the vessel. (Author)

  7. Project of law authorizing the approval of the agreement between the government of the French republic and the government of the Russian federation relative to the civil liability by way of nuclear damage owing to the supply of materials from the French republic devoted to nuclear facilities in the Russian federation

    International Nuclear Information System (INIS)

    Raffarin, J.P.; Villepin, D. de

    2002-01-01

    An agreement between France and Russia was signed on June 20, 2000 about the civil liability of Russia because of the supply of French material devoted to Russian nuclear facilities. This agreement was necessary because Russia do not belong to any of the two big international civil liability systems relative to nuclear energy, i.e. the Paris convention from July 29, 1960 (in the OECD framework) and the Vienna convention from May 21, 1963 (in the IAEA framework). This agreement offers a protection to the French nuclear suppliers against any damage claims in the case of a nuclear accident occurring on the Russian federation territory. This project of law aims at approving this agreement. (J.S.)

  8. Royal Order of 13 May 1980 fixing the maximum amount of liability of the operator for damage caused by a nuclear incident

    International Nuclear Information System (INIS)

    1980-01-01

    The purpose of this Order is to raise the maximum liability of the nuclear operator to one milliard Belgium francs per nuclear incident. This measure was taken with a view to keeping the operator's maximum liability at least at a constant value. (NEA) [fr

  9. Analysis of the microstructural evolution of the damage by neutron irradiation in the pressure vessel of a nuclear power reactor BWR; Analisis de la evolucion microestructural del dano por irradiacion neutronica en la vasija de presion de un reactor nuclear de potencia BWR

    Energy Technology Data Exchange (ETDEWEB)

    Moranchel y R, M.

    2012-07-01

    Nuclear reactor pressure vessel type BWR, installed in Mexico and in many other countries, are made of an alloy of low carbon steel. The American Society for Testing and Materials (Astm) classifies this alloy as A533-B, class 1. Both the vessel and other internal structures are continuously exposed to the neutron flux from the reactions of fission in nuclear fuel. A large number of neutrons reach the vessel and penetrate certain depth depending on their energy. Its penetration in the neutron collides with the nuclei of the atoms out of their positions in the crystal lattice of steel, producing vacancies, interstitial, segregations, among other defects, capable of affecting its mechanical properties. Analyze the micro-structural damage to the vessel due to neutron irradiation, is essential for reasons of integrity of this enclosure and safety of any nuclear power plant. The objective of this thesis work is theoretical and experimentally determine the microstructural damage of a type nuclear reactor vessel steel BWR, due to neutron radiation from the reactor core, using microscopic and spectroscopic techniques as well as Monte Carlo simulation. Microscopy Optical, Scanning Electron Microscopy, Transmission Electron Microscopy, Energy Dispersion of X-rays Spectrometry and X-rays Diffractometry were the techniques used in this research. These techniques helped in the characterization of both the basis of design of pressure vessel steel and steel irradiated, after eight years of neutron irradiation on the vessel, allowing know the surface morphology and crystal structures of the previous steel and post-irradiation, analyze the change in the microstructure of the steel vessel, morphological damage to surface level in an irradiated sample, among which are cavities in the order of microns produced by Atomic displacements due to the impact of neutronic, above all in the first layers of thickness of the vessel, the effect of swelling, regions of greater damage and Atomic

  10. Nuclear survivin and its relationship to DNA damage repair genes in non-small cell lung cancer investigated using tissue array.

    Directory of Open Access Journals (Sweden)

    Songliu Hu

    Full Text Available To investigate the predictive role and association of nuclear survivin and the DNA double-strand breaks repair genes in non-small cell lung cancer (NSCLC: DNA-dependent protein kinase catalytic subunit (DNA-PKcs, Ku heterodimeric regulatory complex 70-KD subunit (Ku70 and ataxia-telangiectasia mutated (ATM.The protein expression of nuclear survivin, DNA-PKcs, Ku70 and ATM were investigated using immunohistochemistry in tumors from 256 patients with surgically resected NSCLC. Furthermore, we analyzed the correlation between the expression of nuclear survivin, DNA-PKcs, Ku70 and ATM. Univariate and multivariate analyses were performed to determine the prognostic factors that inuenced the overall survival and disease-free survival of NSCLC.The expression of nuclear survivin, DNA-PKcs, Ku70 and ATM was significantly higher in tumor tissues than in normal tissues. By dichotomizing the specimens as expressing low or high levels of nuclear survivin, nuclear survivin correlated significantly with the pathologic stage (P = 0.009 and lymph node status (P = 0.004. The nuclear survivin levels were an independent prognostic factor for both the overall survival and the disease-free survival in univariate and multivariate analyses. Patients with low Ku70 and DNA-PKcs expression had a greater benefit from radiotherapy than patients with high expression of Ku70 (P = 0.012 and DNA-PKcs (P = 0.02. Nuclear survivin expression positively correlated with DNA-PKcs (P<0.001 and Ku70 expression (P<0.001.Nuclear survivin may be a prognostic factor for overall survival in patients with resected stage I-IIIA NSCLC. DNA-PKcs and Ku70 could predict the effect of radiotherapy in patients with NSCLC. Nuclear survivin may also stimulates DNA double-strand breaks repair by its interaction with DNA-PKcs and Ku70.

  11. Nuclear Installations Act 1965

    International Nuclear Information System (INIS)

    1965-01-01

    This Act governs all activities related to nuclear installations in the United Kingdom. It provides for the licensing procedure for nuclear installations, the duties of licensees, the competent authorities and carriers of nuclear material in respect of nuclear occurrences, as well as for the system of third party liability and compensation for nuclear damage. The Act repeals the Nuclear Installations (Licensing and Insurance) Act 1959 and the Nuclear Installations (Amendment Act) 1965 except for its Section 17(2). (NEA) [fr

  12. Estimated airborne release of plutonium from the 102 Building at the General Electric Vallecitos Nuclear Center, Vallecitos, California, as a result of postulated damage from severe wind and earthquake hazard

    International Nuclear Information System (INIS)

    Mishima, J.; Ayer, J.E.; Hays, I.D.

    1980-12-01

    This report estimates the potential airborne releases of plutonium as a consequence of various severities of earthquake and wind hazard postulated for the 102 Building at the General Electric Vallecitos Nuclear Center in California. The releases are based on damage scenarios developed by other specialists. The hazard severities presented range up to a nominal velocity of 230 mph for wind hazard and are in excess of 0.8 g linear acceleration for earthquakes. The consequences of thrust faulting are considered. The approaches and factors used to estimate the releases are discussed. Release estimates range from 0.003 to 3 g Pu

  13. Influence of mineralogy and moisture content on plasticity and induced anisotropic damage of a clay-stone: application to nuclear waste disposals

    International Nuclear Information System (INIS)

    Chiarelli, A.S.; Sibai, M.; Karami, M.; Ledesert, B.; Hoteit, N.

    2000-01-01

    The influence of mineralogy and moisture content on mechanical behaviour of a clay-stone rock is studied by the way of uniaxial and triaxial compression tests and microscopic observations. Some parameters characteristic of phenomena like plasticity and induced anisotropic damage are discussed as a function of these two factors. Rock behaviour becomes more brittle when calcite content grows or when clay or moisture content decreases. At the micro-level, plasticity is induced by slip of clay sheets and induced anisotropic damage appears by growth of oriented microcracks at the interface between grains and matrix. (authors)

  14. Analysis of Ling'ao nuclear power station unit 1 exciter No.11 bearing white metal damage and its operating temperature abnormally high

    International Nuclear Information System (INIS)

    Jia Kaili

    2005-01-01

    On the base of analyzing the type of exciter No.11 bearing white metal damage, the root cause and its solution are found. No damage was found on bearing white metal in the later time. On the base of analyzing the structure of the generator end bracket, it is pointed out that when the generator frame is full of pressed gas, the end bracket will deform, that result in the load on No.11 bearing increase, as a result causes the bearing temperature high. A proposal to this problem is presented. (author)

  15. Radiation damage

    CERN Document Server

    Heijne, Erik H M; CERN. Geneva

    1998-01-01

    a) Radiation damage in organic materials. This series of lectures will give an overview of radiation effects on materials and components frequently used in accelerator engineering and experiments. Basic degradation phenomena will be presented for organic materials with comprehensive damage threshold doses for commonly used rubbers, thermoplastics, thermosets and composite materials. Some indications will be given for glass, scintillators and optical fibres. b) Radiation effects in semiconductor materials and devices. The major part of the time will be devoted to treat radiation effects in semiconductor sensors and the associated electronics, in particular displacement damage, interface and single event phenomena. Evaluation methods and practical aspects will be shown. Strategies will be developed for the survival of the materials under the expected environmental conditions of the LHC machine and detectors. I will describe profound revolution in our understanding of black holes and their relation to quantum me...

  16. Nuclear fear revisited

    Science.gov (United States)

    Crease, Robert P.

    2010-10-01

    In 1988 the science historian Spencer Weart published a groundbreaking book called Nuclear Fear: A History of Images, which examined visions of radiation damage and nuclear disaster in newspapers, television, film, literature, advertisements and popular culture.

  17. Nuclear power. BGH ruling of 16.1.1997 (Az: III ZR 117/95) relating to the action for damages in the matter of the shut-down Muehlheim-Kaerl-Kaerlich Reactor

    International Nuclear Information System (INIS)

    Anon.

    1997-01-01

    The German Federal High Court (BGH) non-appealably rejected part of the claims for damages of the owner/operator of the Muehlheim-Kaerlich nuclear power station asserted in an action against the Federal State of Rhineland-Palatinate and remanded the case to the lower court for clarification of the remaining claims. The plant operator claimed compensation for damage incurred in the wake of the annulment of the first partial permit issued for the nuclear power plant in 1975 and declared to be void for reasons of non-compliance with the licensing provisions of section 7, sub-section 2 AtG (Atomic Energy Act), and breach of official duty of civil servants of the licensing authority of Rhineland-Palatinate. Due to this decision of the Federal Administrative Court, the plant was shut down in 1988. The claims asserted by the operator relate among other items to compensation for construction, operation and shut-down operation costs. (orig./CB) [de

  18. Radiation Damage and Dimensional Changes

    International Nuclear Information System (INIS)

    El-Barbary, A.A.; Lebda, H.I.; Kamel, M.A.

    2009-01-01

    The dimensional changes have been modeled in order to be accommodated in the reactor design. This study has major implications for the interpretation of damage in carbon based nuclear fission and fusion plant materials. Radiation damage of graphite leads to self-interstitials and vacancies defects. The aggregation of these defects causes dimensional changes. Vacancies aggregate into lines and disks which heal and contract the basal planes. Interstitials aggregate into interlayer disks which expand the dimension

  19. Apportioning liability for transborder damage

    International Nuclear Information System (INIS)

    Krause-Ablass, W.D.

    1988-01-01

    The author analyses the different legal systems applicable to transfrontier nuclear damage. Using examples, he describes the mechanisms enabling a victim of such damage to identify the competent court and the relevant law, according to whether the provisions of the Paris or the Vienna Convention come into play or whether the rules of private international law, incorporated in the various national laws are applicable (NEA) [fr

  20. Tort Damages

    NARCIS (Netherlands)

    L.T. Visscher (Louis)

    2008-01-01

    textabstractAbstract: In this Chapter, I provide an overview of Law and Economics literature regarding tort damages. Where necessary, attention is also spent to rules of tort liability. Both types of rules provide behavioral incentives to both injurers and victims, with respect to their level of

  1. Nuclear Law: A Key Against Nuclear Terrorism

    International Nuclear Information System (INIS)

    Cardozo, P.

    2004-01-01

    The role of the legal instruments in the war against nuclear terrorism. Control of radioactive sources. Elements of Nuclear Law: Definition: it is the body of special legislation that regulates the pacific uses of nuclear energy and the conduct of the persons engaged in activities related to fissionable materials and ionizing radiation . Objective: to provide a legal framework in order to protect individuals , property and the environment against the harmful effects of the use of nuclear energy and ionising radiation. Principles of nuclear energy legislation: safety principle, exclusively operator responsibility, authorization, independence of the regulatory body, inspections and enforcement, nuclear damage compensation, international cooperation. National regulatory infrastructure. Establishment of special law in Emergency Preparedness for nuclear or radiological disaster. IAEA Conventions. Transportation of nuclear material. IAEA regulations on radioactive material. Compensation for nuclear damage. Nuclear safety, security and terrorism. International and domestic instruments. Anti terrorism acts. International agreements on Safety Cooperation. (Author)

  2. There is possible damages on the nuclear power plants (NPP) of so-frontiers states and operations of the forces of the civil defense (cd) in these situations

    International Nuclear Information System (INIS)

    Ocaqov, H.O.

    2002-01-01

    Full text: According to our forecasts if any type of accident occurs at the nuclear power plant located on the territory of Armenian Republic the radioactive pollution will spread over the territory of Azerbaijan. The injection of radioactive substances and formation of a polluted zone on the significant area including some parts of the territory of Nakhichevan Republic, Nagorny Karabakh, Kelbajar and Kedabek regions are possible. In extraordinary situations occurred due to radiation accidents or under detection of a radioactive pollution the restriction of subsequent irradiation of the population is accomplished by protective measures. These measures are connected to the breakdown of normal live ability of the population, economic and social functioning of the territory i.e. it is an interference causing not only economic and ecological damage but also having adverse influence on the population. A decrease of risk to a possible low level (optimization) is carried out due to the following two circumstances: A time it of risk of a potential irradiation from all possible sources of radiation is regulated and for each source the boundary of risk is established; Under a decrease of potential radiation risk there is the minimum level of risk, below which a risk is considered as negligible and further decrease of risk is inexpedient. Under the accident control and under a realization of urgent reestablishment works it is recommended not to admit an equivalent dose (ED) of radiation more than approximately 500 mSv except for actions on rescue of life or on prevention of further development of the accident and the irradiation of large number of people. Assumed increase of radiation is admitted only for men older than 30 years only on voluntary written approval and preliminary informing them about possible doses of radiation at accident liquidation and about a risk for their health. The persons attracted for realization of emergency and saving work, are considered on the

  3. DNA damage in neurodegenerative diseases

    Energy Technology Data Exchange (ETDEWEB)

    Coppedè, Fabio, E-mail: fabio.coppede@med.unipi.it; Migliore, Lucia, E-mail: lucia.migliore@med.unipi.it

    2015-06-15

    Highlights: • Oxidative DNA damage is one of the earliest detectable events in the neurodegenerative process. • The mitochondrial DNA is more vulnerable to oxidative attack than the nuclear DNA. • Cytogenetic damage has been largely documented in Alzheimer's disease patients. • The question of whether DNA damage is cause or consequence of neurodegeneration is still open. • Increasing evidence links DNA damage and repair with epigenetic phenomena. - Abstract: Following the observation of increased oxidative DNA damage in nuclear and mitochondrial DNA extracted from post-mortem brain regions of patients affected by neurodegenerative diseases, the last years of the previous century and the first decade of the present one have been largely dedicated to the search of markers of DNA damage in neuronal samples and peripheral tissues of patients in early, intermediate or late stages of neurodegeneration. Those studies allowed to demonstrate that oxidative DNA damage is one of the earliest detectable events in neurodegeneration, but also revealed cytogenetic damage in neurodegenerative conditions, such as for example a tendency towards chromosome 21 malsegregation in Alzheimer's disease. As it happens for many neurodegenerative risk factors the question of whether DNA damage is cause or consequence of the neurodegenerative process is still open, and probably both is true. The research interest in markers of oxidative stress was shifted, in recent years, towards the search of epigenetic biomarkers of neurodegenerative disorders, following the accumulating evidence of a substantial contribution of epigenetic mechanisms to learning, memory processes, behavioural disorders and neurodegeneration. Increasing evidence is however linking DNA damage and repair with epigenetic phenomena, thereby opening the way to a very attractive and timely research topic in neurodegenerative diseases. We will address those issues in the context of Alzheimer's disease

  4. DNA damage in neurodegenerative diseases

    International Nuclear Information System (INIS)

    Coppedè, Fabio; Migliore, Lucia

    2015-01-01

    Highlights: • Oxidative DNA damage is one of the earliest detectable events in the neurodegenerative process. • The mitochondrial DNA is more vulnerable to oxidative attack than the nuclear DNA. • Cytogenetic damage has been largely documented in Alzheimer's disease patients. • The question of whether DNA damage is cause or consequence of neurodegeneration is still open. • Increasing evidence links DNA damage and repair with epigenetic phenomena. - Abstract: Following the observation of increased oxidative DNA damage in nuclear and mitochondrial DNA extracted from post-mortem brain regions of patients affected by neurodegenerative diseases, the last years of the previous century and the first decade of the present one have been largely dedicated to the search of markers of DNA damage in neuronal samples and peripheral tissues of patients in early, intermediate or late stages of neurodegeneration. Those studies allowed to demonstrate that oxidative DNA damage is one of the earliest detectable events in neurodegeneration, but also revealed cytogenetic damage in neurodegenerative conditions, such as for example a tendency towards chromosome 21 malsegregation in Alzheimer's disease. As it happens for many neurodegenerative risk factors the question of whether DNA damage is cause or consequence of the neurodegenerative process is still open, and probably both is true. The research interest in markers of oxidative stress was shifted, in recent years, towards the search of epigenetic biomarkers of neurodegenerative disorders, following the accumulating evidence of a substantial contribution of epigenetic mechanisms to learning, memory processes, behavioural disorders and neurodegeneration. Increasing evidence is however linking DNA damage and repair with epigenetic phenomena, thereby opening the way to a very attractive and timely research topic in neurodegenerative diseases. We will address those issues in the context of Alzheimer's disease

  5. Dynamics of radiation damage and repair processes in coniferous stands in a 10-km region of the Chernobyl nuclear power station

    International Nuclear Information System (INIS)

    Kozubov, G.M.; Taskaev, A.I.

    1995-01-01

    Properties of morphogenesis, growth dynamics, anatomy and ultrastructure of wood and needle, reproductive processes in coniferous plants were studied under different level of radiation effect in the 10-km zone in 1986-1992. It was established that the full drying of pine forests began under absorbed dose 80-100 Gy/year. Threshold doses, after which repair processes were possible, reached to 10-12 Gy/year for Picea abies and 50 Gy/year for Pinus sylvestris. Three maine stages are revealed in dynamics of radiation damage and repair processes in studied conifers and their morphological and functional characteristic is presented. 14 refs., 3 figs., 2 tabs

  6. Induction of DNA damage in γ-irradiated nuclei stripped of nuclear protein classes: differential modulation of double-strand break and DNA-protein crosslink formation

    International Nuclear Information System (INIS)

    Xue, L.-Y.; Friedman, L.R.; Oleinick, N.L.; Chiu, S.-M.

    1994-01-01

    The influence of chromatin proteins on the induction of DNA double-strand breaks (dsb) and DNA-protein crosslinks (dpc) by γ-radiation was investigated. Low molecular weight non-histone proteins and classes of histones were extracted with increasing concentrations of NaC1, whereas nuclear matrix proteins were not extractable even by 2.0 M NACl. The yield of dsb increased with progressive removal of proteins from chromatin. The data support our previous conclusion that nuclear matrix protein rather than the majority of the histones are the predominant substrates for dpc production, although the involvement of a subset of tightly bound histones (H3 and H4) has not been excluded. This finding demonstrates that chromatin proteins can differentially modify the yield of two types of radiation-induced DNA lesions. (author)

  7. Radiation damage of structural materials

    CERN Document Server

    Koutsky, Jaroslav

    1994-01-01

    Maintaining the integrity of nuclear power plants is critical in the prevention or control of severe accidents. This monograph deals with both basic groups of structural materials used in the design of light-water nuclear reactors, making the primary safety barriers of NPPs. Emphasis is placed on materials used in VVER-type nuclear reactors: Cr-Mo-V and Cr-Ni-Mo-V steel for RPV and Zr-Nb alloys for fuel element cladding. The book is divided into 7 main chapters, with the exception of the opening one and the chapter providing a phenomenological background for the subject of radiation damage. Ch

  8. Evaluation methods for corrosion damage of components in cooling systems of nuclear power plants by coupling analysis of corrosion and flow dynamics (1). Major targets and development strategies of the evaluation methods

    International Nuclear Information System (INIS)

    Naitoh, Masanori; Uchida, Shunsuke; Koshizuka, Seiichi; Ninokata, Hisashi; Hiranuma, Naoki; Dosaki, Koji; Nishida, Koji; Akiyama, Minoru; Saitoh, Hiroaki

    2008-01-01

    Problems in major components and structural materials in nuclear power plants have often been caused by flow induced vibration and corrosion and their overlapping effects. In order to establish safe and reliable plant operation, future problems for structural materials should be predicted based on combined analyses of flow dynamics and corrosion and they should be mitigated before becoming serious issues for plant operation. Three approaches have been prepared for predicting future problems in structural materials: 1. Computer program packages for predicting future corrosion fatigue on structural materials, 2. Computer program packages for predicting future corrosion damage on structural materials, and 3. Computer program packages for predicting wall thinning caused by flow accelerated corrosion. General features of evaluation methods and their computer packages, technical innovations required for their development, and application plans for the developed approaches for plant operation are introduced in this paper. (author)

  9. Analysis of the micro-structural damages by neutronic irradiation of the steel of reactor vessels of the nuclear power plant of Laguna Verde. Characterization of the design steel; Analisis de los danos micro-estructurales por irradiacion neutronica del acero de la vasija de los reactores de la Central Nuclear de Laguna Verde. Caracterizacion del acero de diseno

    Energy Technology Data Exchange (ETDEWEB)

    Moranchel y Rodriguez, M.; Garcia B, A. [IPN, Escuela Superior de Fisica y Matematicas, Departamento de Fisica, Av. Luis Enrique Erro s/n, Unidad Profesional Adolfo Lopez Mateos, Col. Lindavista, 07738 Mexico D. F. (Mexico); Longoria G, L. C., E-mail: mmoranchel@ipn.m [ININ, Direccion de Investigacion Cientifica, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2010-09-15

    The vessel of a nuclear reactor is one of the safety barriers more important in the design, construction and operation of the reactor. If the vessel results affected to the grade of to have fracture and/or cracks it is very probable the conclusion of their useful life in order to guarantee the nuclear safety and the radiological protection of the exposure occupational personnel, of the public and the environment avoiding the exposition to radioactive sources. The materials of the vessel of a nuclear reactor are exposed continually to the neutronic irradiation that generates the same nuclear reactor. The neutrons that impact to the vessel have the sufficient energy to penetrate certain depth in function of the energy of the incident neutron until reaching the repose or to be absorbed by some nucleus. In the course of their penetration, the neutrons interact with the nuclei, atoms, molecules and with the same crystalline nets of the vessel material producing vacuums, interstitial, precipitate and segregations among other defects that can modify the mechanical properties of the steel. The steel A533-B is the material with which is manufactured the vessel of the nuclear reactors of nuclear power plant of Laguna Verde, is an alloy that, among other components, it contains atoms of Ni that if they are segregated by the neutrons impact this would favor to the cracking of the same vessel. This work is part of an investigation to analyze the micro-structural damages of the reactor vessels of the nuclear power plant of Laguna Verde due to the neutronic irradiation which is exposed in a continuous way. We will show the characterization of the design steel of the vessel, what offers a comprehension about their chemical composition, the superficial topography and the crystalline nets of the steel A533-B. It will also allow analyze the existence of precipitates, segregates, the type of crystalline net and the distances inter-plains of the design steel of the vessel. (Author)

  10. Romanian Nuclear Liability Legislation

    International Nuclear Information System (INIS)

    Banu, R.

    2006-01-01

    The regime of civil liability for nuclear damages in the Romanian legislation is defined especially by the Law no. 703/2001 on civil liability for nuclear damage, as well as the Government Decision no. 894/2003 for the approval of the Norms for the enforcement of Law no. 703/2001. These two documents constitute the legal framework that regulates the third party civil liability for nuclear damages. The paper is proposing to present the main elements of the relatively recent legal framework, namely: the principles content in the international acts on civil liability for nuclear damages, the subject to whom such law applies, the regime of civil liability for nuclear damages in Romania and provisions regarding the terrorist acts.(author)

  11. Nuclear risk

    International Nuclear Information System (INIS)

    Mulkers, G.

    1988-01-01

    This file includes data on risks insured by the nuclear insurance pool in Belgium and on the Chernobyl accident covering injury, economic damage and compensation for the latter. Also included are the texts of the IAEA Conventions on Early Notification and on Assistance in Case of a Nuclear Accident as well as that of a Convention on long-distance transfrontier atmospheric pollution signed in Geneva [fr

  12. American nuclear insurers

    International Nuclear Information System (INIS)

    Oliveira, R.A.

    1988-01-01

    Nuclear liability insurance covers liability for damages directly caused by the nuclear energy hazard. This coverage includes offsite bodily injury and property damage sustained by members of the general public, and bodily injury to onsite third party personnel. Recent nuclear liability claims allege bodily injury and property damage resulting from releases or radioactive materials to the environmental and occupational radiation worker exposures. Routine reactor operations involving radioactive waste have the potential to result in such claims. The nuclear insurance Pools believe that one way such claims can be minimized is through the implementation of an effective radioactive waste management program

  13. Analysis of core damage frequency: Nuclear power plant Dukovany, VVER/440 V-213 Unit 1, internal events. Volume 1: Main report

    International Nuclear Information System (INIS)

    Pugila, W.J.

    1994-01-01

    This report presents the final results from the Level 1 probabilistic safety assessment (PSA) for the Dukovany VVER/440 V-213 nuclear power plant, Unit 1. Section 1.1 describes the objectives of this study. Section 1.2 discusses the approach that was used for completing the Dukovany PSA. Section 1.3 summarizes the results of the PSA. Section 1.4 provides a comparison of the results of the Dukovany PSA with the results of other PSAs for different types of reactors worldwide. Section 1.5 summarizes the conclusions of the Dukovany PSA

  14. In honour of N. Yngve Öhrn: surveying proton cancer therapy reactions with Öhrn's electron nuclear dynamics method. Aqueous clusters radiolysis and DNA-base damage by proton collisions

    Science.gov (United States)

    Mclaurin, Patrick M.; Privett, Austin J.; Stopera, Christopher; Grimes, Thomas V.; Perera, Ajith; Morales, Jorge A.

    2015-02-01

    Proton cancer therapy (PCT) utilises high-energy H+ projectiles to cure cancer. PCT healing arises from its DNA damage in cancerous cells, which is mostly inflicted by the products from PCT water radiolysis reactions. While clinically established, a complete microscopic understanding of PCT remains elusive. To help in the microscopic elucidation of PCT, Professor Öhrn's simplest-level electron nuclear dynamics (SLEND) method is herein applied to H+ + (H2O)3-4 and H+ + DNA-bases at ELab = 1.0 keV. These are two types of computationally feasible prototypes to study water radiolysis reactions and H+-induced DNA damage, respectively. SLEND is a time-dependent, variational, non-adiabatic and direct-dynamics method that adopts a nuclear classical-mechanics description and an electronic single-determinantal wavefunction. Additionally, our SLEND + effective-core-potential method is herein employed to simulate some computationally demanding PCT reactions. Due to these attributes, SLEND proves appropriate for the simulation of various types of PCT reactions accurately and feasibly. H+ + (H2O)3-4 simulations reveal two main processes: H+ projectile scattering and the simultaneous formation of H and OH fragments; the latter process is quantified through total integrals cross sections. H+ + DNA-base simulations reveal atoms and groups displacements, ring openings and base-to-proton electron transfers as predominant damage processes. The authors warmly dedicate this SLEND investigation in honour of Professor N. Yngve Öhrn on the occasion of his 80th birthday celebration during the 54th Sanibel Symposium in St. Simons' Island, Georgia, on February 16-21, 2014. Associate Professor Jorge A. Morales was a former chemistry PhD student under the mentorship of Professor Öhrn and Dr Ajith Perera took various quantum chemistry courses taught by Professor Öhrn during his chemistry PhD studies. Both Jorge and Ajith look back to those great times of their scientific formation under

  15. Responsability of nuclear industry

    International Nuclear Information System (INIS)

    Cadiz Deleito, J.C.

    1985-01-01

    Since the beginning of nuclear industry, civil responsibility with damages to the public health and properties was a critical problem, because the special conditions of this industry (nuclear accident, damages could be very high but probability of these events is very low). Legal precepts, universally accepted, in the first 60 years for all countries interested in nuclear energy are being revised, then 20 years of experience. The civil responsibility limited is being questioned and indemnities updated. (author)

  16. Design of the accelerator stand with the ecr-source for simulation experiments on the of radiation damage of the steels of the nuclear industry

    International Nuclear Information System (INIS)

    Chalykh, B.B.; Kuybeda, R.P.; Kulevoy, T.V.; Ziyatdinova, A.V.

    2014-01-01

    The imitation experiments of irradiation resistivity for steels used in nuclear industry by heavy ion beams are promising demand for material properties investigation. The formation of the defects on the real-existing reactors is fraught with many difficulties such as a long-term session of exposure and induced radioactivity in samples. Simulation of radiation defects on accelerators of charged particles does not have such a drawback. To form radiation defects in matter, it is necessary to have beams of various ions with different energy. The concept of the test bench based on a ECR heavy-ion source for the imitation experiments of the materials resistance under irradiation is presented and discussed.

  17. Estimating the lifetimes of titanium containers for nuclear fuel waste: A damage function for the crevice corrosion of grade-2 titanium

    International Nuclear Information System (INIS)

    Shoesmith, D.W.; Ikeda, B.M.; Quinn, M.J.; Kolar, M.

    1995-06-01

    The assumptions upon which the lifetime failure model used in the postclosure assessment is based are reevaluated. In particular, the conservations involved in assuming that crevice initiation would occur, and that sufficient oxygen would be present to maintain crevice propagation to failure, are discussed. Unless the period required to saturate the environment around the container can be specified with some certainty, it remains necessary to assume corrosion would initiate rapidly on all containers. A modified version of the container lifetime model has been developed which avoids the need to use averaged temperature profiles. In this model, these profiles are converted to propagation rate profiles using an experimental activation energy and then numerically integrated to predict container failure times. A damage function is developed relating the maximum depth of penetration by crevice corrosion to either the time since emplacement in the vault or the total amount of oxygen consumed. This function is used to estimate the maximum penetration depth expected if all the oxygen available in a borehole is consumed in crevice corrosion and to determine the impact on container lifetimes of various repassivation criteria. The factors likely to cause repassivation are summarized, and a number of engineering approaches to extending container lifetimes suggested. (author). 22 refs., 1 tab., 17 figs

  18. [Economic damage caused by lowered prices in the agro-food sector in areas contaminated by radioactive materials leaked from the nuclear power plant severely damaged by the 2011 Great East Japan Earthquake--consideration from the viewpoints of epidemiology, economics and social psychology].

    Science.gov (United States)

    Sugita, Minoru; Miyakawa, Michiko

    2013-01-01

    Large amounts of radioactive materials were leaked into the environment from the Fukushima Daiichi Nuclear Power Plant (FDNPP) of the Tokyo Electric Power Company, which was severely damaged by the 2011 Tohoku Region Pacific Coast Earthquake and accompanying tsunami. Economic damage due to lowered prices and supplies of food products produced in the areas contaminated by the radioactive materials leaked from the damaged FDNPP to the agro-food sector in the affected areas is notable. In Japanese, this is known as fuhyo higai. In this study, we investigated fuhyo higai from the viewpoints of epidemiology, economics, and social psychology in an effort to seek solutions. Information was obtained from articles in print and on the Internet. Fuhyo higai, or economic damage of the agro-food sector, which is the main industry in the contaminated areas, is serious because it is difficult to reassure the general population regarding food safety. This fuhyo higai does not derive solely from rumor. It has been reported that improving the science literacy of the general population is important as a countermeasure against fuhyo higai, but this may not be effective because of the human social structure and behavior of people who seek subjective safety. Almost all radiological laboratory results of samples of food produced in the contaminated areas were below detectable limits. Very high values were rarely detected. In general, information about the dose-response relationship is obtained under the assumption that there may be error in the response but not in the dose. The rare cases of extremely high radiological values of food samples from the contaminated areas may correspond to large errors in dose. However, it is difficult to deny a high-dose risk. The reported information on the dose-response relationship obtained under the assumption that there is no error in dose is not sufficient. Thus, response, i.e., health risk, cannot be correctly estimated. This leads the general

  19. Electricity and nuclear energy

    International Nuclear Information System (INIS)

    Krafft, P.

    1987-01-01

    Consequences of getting out from nuclear energy are discussed. It is concluded that the Chernobyl accident is no reason to withdraw confidence from Swiss nuclear power plants. There are no sufficient economizing potential and other energies at disposal to substitute nuclear energy. Switching to coal, oil and gas would increase environmental damages. Economic and social cost of getting out would be too high

  20. Nuclear Energy in Perspective

    International Nuclear Information System (INIS)

    1989-01-01

    This report provides the interested non-specialist reader with insights on five major issues associated with nuclear power generation: nuclear development and economics, protection of man and the environment, power plant safety, radioactive waste management and compensation for damage from a nuclear accident

  1. Damaged Skylab

    Science.gov (United States)

    1973-01-01

    The Saturn V vehicle, carrying the unmarned orbital workshop for the Skylab-1 mission, lifted off successfully and all systems performed normally. Sixty-three seconds into the flight, engineers in the operation support and control center saw an unexpected telemetry indication that signalled that damages occurred on one solar array and the micrometeoroid shield during the launch. The micrometeoroid shield, a thin protective cylinder surrounding the workshop protecting it from tiny space particles and the sun's scorching heat, ripped loose from its position around the workshop. This caused the loss of one solar wing and jammed the other. Still unoccupied, the Skylab was stricken with the loss of the heat shield and sunlight beat mercilessly on the lab's sensitive skin. Internal temperatures soared, rendering the station uninhabitable, threatening foods, medicines, films, and experiments. This image, taken during a fly-around inspection by the Skylab-2 crew, shows a crippled Skylab in orbit. The crew found their home in space to be in serious shape; the heat shield gone, one solar wing gone, and the other jammed. The Marshall Space Flight Center (MSFC) developed, tested, rehearsed, and approved three repair options. These options included a parasol sunshade and a twin-pole sunshade to restore the temperature inside the workshop, and a set of metal cutting tools to free the jammed solar panel.

  2. Structural damage

    International Nuclear Information System (INIS)

    Gray, R.E.; Bruhn, R.W.

    1992-01-01

    Virtually all structures show some signs of distress due to deterioration of the building components, to changed loads, or to changed support conditions. Changed support conditions result from ground movements. In mining regions many cases of structural distress are attributed to mining without considering alternative causes. This is particularly true of coal mining since it occurs under extensive areas. Coal mining is estimated to have already undermined more than eight million acres and may eventually undermine 40 million acres in the United States. Other nonmetal and metal underground mines impact much smaller areas. Although it is sometimes difficult, even with careful study, to identify the actual cause of damage, persons responsible for underground coal mining should at least be aware of possible causes of building stress other than mine subsidence. This paper presents information on distress to structures and briefly reviews a number of causes of ground movements other than subsidence: Mass movements, dissolution, erosion, frost action, shrinking and swelling, yield into excavations and compressibility

  3. Nuclear Safety

    International Nuclear Information System (INIS)

    1978-09-01

    In this short paper it has only been possible to deal in a rather general way with the standards of safety used in the UK nuclear industry. The record of the industry extending over at least twenty years is impressive and, indeed, unique. No other industry has been so painstaking in protection of its workers and in its avoidance of damage to the environment. Headings are: introduction; how a nuclear power station works; radiation and its effects (including reference to ICRP, the UK National Radiological Protection Board, and safety standards); typical radiation doses (natural radiation, therapy, nuclear power programme and other sources); safety of nuclear reactors - design; key questions (matters of concern which arise in the public mind); safety of operators; safety of people in the vicinity of a nuclear power station; safety of the general public; safety bodies. (U.K.)

  4. Radiation damage prediction system using damage function

    International Nuclear Information System (INIS)

    Tanaka, Yoshihisa; Mori, Seiji

    1979-01-01

    The irradiation damage analysis system using a damage function was investigated. This irradiation damage analysis system consists of the following three processes, the unfolding of a damage function, the calculation of the neutron flux spectrum of the object of damage analysis and the estimation of irradiation effect of the object of damage analysis. The damage function is calculated by applying the SAND-2 code. The ANISN and DOT3, 5 codes are used to calculate neutron flux. The neutron radiation and the allowable time of reactor operation can be estimated based on these calculations of the damage function and neutron flux. The flow diagram of the process of analyzing irradiation damage by a damage function and the flow diagram of SAND-2 code are presented, and the analytical code for estimating damage, which is determined with a damage function and a neutron spectrum, is explained. The application of the irradiation damage analysis system using a damage function was carried out to the core support structure of a fast breeder reactor for the damage estimation and the uncertainty evaluation. The fundamental analytical conditions and the analytical model for this work are presented, then the irradiation data for SUS304, the initial estimated values of a damage function, the error analysis for a damage function and the analytical results are explained concerning the computation of a damage function for 10% total elongation. Concerning the damage estimation of FBR core support structure, the standard and lower limiting values of damage, the permissible neutron flux and the allowable years of reactor operation are presented and were evaluated. (Nakai, Y.)

  5. Liability for damage to the global commons

    International Nuclear Information System (INIS)

    Leigh, K.

    1993-01-01

    The 'global commons' discussed in this paper are the areas beyond the limits of national jurisdiction. Responsibility to prevent environmental damage to these areas is clearly recognized in customary international law. On the other hand, although liability for such damage undoubtedly has a useful role to play in protecting these areas, the precise nature of liability for such damage is unclear. Some issues, such as whether liability for such damage is strict or tied to breaching a standard of care and the definition of environmental damage, equally arise in relation to damage to the environment of States. Others, such as who could take action to enforce the liability and the nature of the remedy, raise special problems in the case of damage to the global commons. The work under way in the IAEA Standing Committee on Liability for Nuclear Damage provides an opportunity for clarifying these issues in relation to nuclear damage to the global commons. Treaties dealing with particular types of damage which have recently been adopted or are currently being developed in other fields provide a starting point in dealing with this matter. More work, however, needs to be done

  6. Effective atomic number, energy loss and radiation damage studies in some materials commonly used in nuclear applications for heavy charged particles such as H, C, Mg, Fe, Te, Pb and U

    Science.gov (United States)

    Kurudirek, Murat

    2016-05-01

    Commonly used nuclear physics materials such as water, concrete, Pb-glass, paraffin, freon and P 10 gases, some alloys such as brass, bronze, stainless-steel and some scintillators such as anthracene, stilbene and toluene have been investigated with respect to the heavy charged particle interaction as means of projected range and effective atomic number (Zeff) in the energy region 10 keV to 10 MeV. Calculations were performed for heavy ions such as H, C, Mg, Fe, Te, Pb and U. Also, the energy loss and radiation damage were studied using SRIM Monte Carlo code for anthracene for different heavy ions of 100 keV kinetic energy. It has been observed that the variation in Zeff becomes less when the atomic number of the ions increase. Glass-Pb, bronze, brass, stainless-steel and Freon gas were found to vary less than 10% in the energy region 10 keV to 10 MeV. For total proton interaction, discrepancies up to 10% and 18% between two databases namely PSTAR and SRIM were noted in mass stopping power and Zeff of water, respectively. The range calculations resulted with a conclusion that the metal alloys and glass-Pb have lowest values of ranges confirming best shielding against energetic heavy ions whereas freon and P 10 gases have the highest values of ranges in the entire energy region. The simulation results showed that the energy loss (%) to target electrons decreases as the Z of the incident ion increases. Also, it was observed that the radiation damage first increases with Z of the ion and then keeps almost constant for ions with Z≥52.

  7. Historical aspects of the nuclear right development

    International Nuclear Information System (INIS)

    Puig, Diva E.

    1999-01-01

    This paper analyses the historical aspects of the nuclear right development. It makes the evolution of the fundamental principles of nuclear right, in special, the civil responsibility for nuclear damages. (author)

  8. The C-terminal region of Rad52 is essential for Rad52 nuclear and nucleolar localization, and accumulation at DNA damage sites immediately after irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Koike, Manabu, E-mail: m_koike@nirs.go.jp [DNA Repair Gene Res., National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Yutoku, Yasutomo [DNA Repair Gene Res., National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan); Graduate School of Science, Chiba University, Yayoicho, Inage-ku, Chiba 263-8522 (Japan); Koike, Aki [DNA Repair Gene Res., National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555 (Japan)

    2013-05-31

    Highlights: •Rad52 might play a key role in the repair of DSB immediately after irradiation. •EYFP-Rad52 accumulates rapidly at DSB sites and colocalizes with Ku80. •Accumulation of Rad52 at DSB sites is independent of the core NHEJ factors. •Localization and recruitment of Rad52 to DSB sites are dependent on the Rad52 CTR. •Basic amino acids in Rad52 CTR are highly conserved among vertebrate species. -- Abstract: Rad52 plays essential roles in homologous recombination (HR) and repair of DNA double-strand breaks (DSBs) in Saccharomyces cerevisiae. However, in vertebrates, knockouts of the Rad52 gene show no hypersensitivity to agents that induce DSBs. Rad52 localizes in the nucleus and forms foci at a late stage following irradiation. Ku70 and Ku80, which play an essential role in nonhomologous DNA-end-joining (NHEJ), are essential for the accumulation of other core NHEJ factors, e.g., XRCC4, and a HR-related factor, e.g., BRCA1. Here, we show that the subcellular localization of EYFP-Rad52(1–418) changes dynamically during the cell cycle. In addition, EYFP-Rad52(1–418) accumulates rapidly at microirradiated sites and colocalizes with the DSB sensor protein Ku80. Moreover, the accumulation of EYFP-Rad52(1–418) at DSB sites is independent of the core NHEJ factors, i.e., Ku80 and XRCC4. Furthermore, we observed that EYFP-Rad52(1–418) localizes in nucleoli in CHO-K1 cells and XRCC4-deficient cells, but not in Ku80-deficient cells. We also found that Rad52 nuclear localization, nucleolar localization, and accumulation at DSB sites are dependent on eight amino acids (411–418) at the end of the C-terminal region of Rad52 (Rad52 CTR). Furthermore, basic amino acids on Rad52 CTR are highly conserved among mammalian, avian, and fish homologues, suggesting that Rad52 CTR is important for the regulation and function of Rad52 in vertebrates. These findings also suggest that the mechanism underlying the regulation of subcellular localization of Rad52 is

  9. Injection of nano-particles in mitigating flow accelerated corrosion (FAC) damage in the secondary system of nuclear power plants (NPPs)

    International Nuclear Information System (INIS)

    Lim, Dong Seok; Ku, Hee Kwon; Cho, Jae Seon

    2015-01-01

    NPPs produces electric energy through phase transition of water. According to this, a piping, which is flow path, integrity is essential for safety functions. Erosion, FAC and fittings are corrosion failure mechanism by increasing service life. Especially, there are 10-kilometers of piping in secondary systems. It needs to estimate FAC and apply periodic management. Iron oxides produced by FAC cause power reduction and Loss Of Coolant Accident (LOCA) will be occurred through the continued piping wall thinning. In this study, corrosion rate of pipe materials with carbon steel(SA106.Gr.B) and low-alloy steel (SA335.P22) was evaluated for pipe configuration and dissolved oxygen concentration on 150 °C, pH 9.5∼10.0 and flow velocity of 5m/s. Temperature of 150°C is well known that causes high FAC rate and pH consider a NPPs in-service condition. Further corrosion rate test was performed to develop FAC reduction technology through Pt-nanoparticle injection. In this study, corrosion rate is evaluated by weight depletion method. The results of material impact assessment show that corrosion rate of carbon steel is more higher than that of low-alloy steel because of Cr content. And also, the results of pipe configuration test show that case with 90° elbow had maximum wall thinning than with 180° horizontal pipe. The dissolved oxygen concentration test shows that low oxygen condition, ≤5 ppb, had high corrosion rate compared to normal condition and the corrosion rate decreased 50% at Pt-nanoparticle injection test on maximum corrosion rate condition compared to maximum wall thinning condition without Pt-nanoparticle injection. In this study, samples provided by each test case had analyzed through SEM-EDX (Scanning Electron Microscopy-Energy Dispersive X-ray Spectroscopy). Behavior evaluation for oxide film was performed and Electrochemical corrosion potential (ECP) was measured for electrochemistry evaluation. To apply Pt-nanoparticle injection technology on nuclear

  10. A rigorous treatment of uncertainty quantification for Silicon damage metrics

    International Nuclear Information System (INIS)

    Griffin, P.

    2016-01-01

    These report summaries the contributions made by Sandia National Laboratories in support of the International Atomic Energy Agency (IAEA) Nuclear Data Section (NDS) Technical Meeting (TM) on Nuclear Reaction Data and Uncertainties for Radiation Damage. This work focused on a rigorous treatment of the uncertainties affecting the characterization of the displacement damage seen in silicon semiconductors. (author)

  11. Apportioning liability for transborder damages

    International Nuclear Information System (INIS)

    Krause-Ablass, W.-D.

    1988-01-01

    The legal situation in the case of cross border damage being caused by reactor accidents or transportation of nuclear material through more than one country is analysed. Two questions have to be asked - which country's courts have jurisdiction over the claims for damage? and which law is applicable? In considering the jurisdiction problem, the Paris and Vienna Conventions are discussed and also other rules of jurisdiction. The way the law is applicable is discussed in the second section. When the action for liability is based on the Paris or Vienna Convention the issue of reciprocity may arise and this is discussed. After a nuclear incident a potential plaintiff may have a choice amongst various jurisdictions and various available laws. Success may depend on the right choice of the forum chosen. This is illustrated by two examples. (U.K.)

  12. Burn-up Credit Criticality Safety Benchmark Phase III-C. Nuclide Composition and Neutron Multiplication Factor of a Boiling Water Reactor Spent Fuel Assembly for Burn-up Credit and Criticality Control of Damaged Nuclear Fuel

    International Nuclear Information System (INIS)

    Suyama, K.; Uchida, Y.; Kashima, T.; Ito, T.; Miyaji, T.

    2016-01-01

    Criticality control of damaged nuclear fuel is one of the key issues in the decommissioning operation of the Fukushima Daiichi Nuclear Power Station accident. The average isotopic composition of spent nuclear fuel as a function of burn-up is required in order to evaluate criticality parameters of the mixture of damaged nuclear fuel with other materials. The NEA Expert Group on Burn-up Credit Criticality (EGBUC) has organised several international benchmarks to assess the accuracy of burn-up calculation methodologies. For BWR fuel, the Phase III-B benchmark, published in 2002, was a remarkable landmark that provided general information on the burn-up properties of BWR spent fuel based on the 8x8 type fuel assembly. Since the publication of the Phase III-B benchmark, all major nuclear data libraries have been revised; in Japan from JENDL-3.2 to JENDL-4, in Europe from JEF-2.2 to JEFF-3.1 and in the US from ENDF/B-VI to ENDF/B-VII.1. Burn-up calculation methodologies have been improved by adopting continuous-energy Monte Carlo codes and modern neutronics calculation methods. Considering the importance of the criticality control of damaged fuel in the Fukushima Daiichi Nuclear Power Station accident, a new international burn-up calculation benchmark for the 9 x 9 STEP-3 BWR fuel assemblies was organised to carry out the inter-comparison of the averaged isotopic composition in the interest of the burnup credit criticality safety community. Benchmark specifications were proposed and approved at the EGBUC meeting in September 2012 and distributed in October 2012. The deadline for submitting results was set at the end of February 2013. The basic model for the benchmark problem is an infinite two-dimensional array of BWR fuel assemblies consisting of a 9 x 9 fuel rod array with a water channel in the centre. The initial uranium enrichment of fuel rods without gadolinium is 4.9, 4.4, 3.9, 3.4 and 2.1 wt% and 3.4 wt% for the rods using gadolinium. The burn-up conditions are

  13. Nuclear factor erythroid 2-related factor 2 antioxidant response element pathways protect bovine mammary epithelial cells against H2O2-induced oxidative damage in vitro.

    Science.gov (United States)

    Ma, Y F; Wu, Z H; Gao, M; Loor, J J

    2018-03-21

    The experiment was conducted to determine the role of nuclear factor (erythroid-derived 2)-like factor 2 (NFE2L2, formerly Nrf2) antioxidant response element (ARE) pathway in protecting bovine mammary epithelial cells (BMEC) against H 2 O 2 -induced oxidative stress injury. An NFE2L2 small interfering RNA (siRNA) interference or a pCMV6-XL5-NFE2L2 plasmid fragment was transfected to independently downregulate or upregulate expression of NFE2L2. Isolated BMEC in triplicate were exposed to H 2 O 2 (600 μM) for 6 h to induce oxidative stress before transient transfection with scrambled siRNA, NFE2L2-siRNA, pCMV6-XL5, and pCMV6-XL5-NFE2L2. Cell proliferation, apoptosis and necrosis rates, antioxidant enzyme activities, reactive oxygen species (ROS) and malondialdehyde (MDA) production, protein and mRNA expression of NFE2L2 and downstream target genes, and fluorescence activity of ARE were measured. The results revealed that compared with the control, BMEC transfected with NFE2L2-siRNA3 had proliferation rates that were 9 or 65% lower without or with H 2 O 2 , respectively. These cells also had apoptosis and necrosis rates that were 27 and 3.5 times greater with H 2 O 2 compared with the control group, respectively. In contrast, transfected pCMV6-XL5-NFE2L2 had proliferation rates that were 64.3% greater or 17% lower without or with H 2 O 2 compared with the control group, respectively. Apoptosis rates were 1.8 times lower with H 2 O 2 compared with the control. In addition, compared with the control, production of ROS and MDA and activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), and glutathione-S-transferase (GST) increased markedly in cells transfected with pCMV6-XL5-NFE2L2 and without H 2 O 2 . However, compared with the control, production of ROS and MDA and activity of CAT and GSH-Px increased markedly, whereas activities of SOD and GST decreased in cells transfected with pCMV6-XL5-NFE2L2 and incubated with H 2 O 2

  14. Insurance of nuclear risk

    International Nuclear Information System (INIS)

    Lacroix, M.

    1976-01-01

    Insurance for large nuclear installations covers mainly four types of risk: third party liability which in accordance with the nuclear conventions, is borne by a nuclear operator following an incident occurring in his installation or during transport of nuclear substances; material damage to the installation itself, which precisely is not covered by third party liability insurance; machinery breakdown, i.e. accidental damage or interruption of operation. Only the first category must be insured. In view of the magnitude of the risk, nuclear insurance resorts to co-insurance and reinsurance techniques which results in a special organisation of the nuclear insurance market, based on national nuclear insurance pools and on the Standing Committee on Atomic Risk of the European Insurance Committee. Conferences of the chairmen of nuclear insurance pools are convened regularly at a worldwide level. (NEA) [fr

  15. Radiation damage of structural materials

    International Nuclear Information System (INIS)

    Koutsky, J.; Kocik, J.

    1994-01-01

    Maintaining the integrity of nuclear power plants (NPP) is critical in the prevention or control of severe accidents. This monograph deals with both basic groups of structural materials used in the design of light-water nuclear reactors, making the primary safety barriers of NPPs. Emphasis is placed on materials used in VVER-type nuclear reactors: Cr-Mo-V and Cr-Ni-Mo-V steel for reactor pressure vessels (RPV) and Zr-Nb alloys for fuel element cladding. The book is divided into seven main chapters, with the exception of the opening one and the chapter providing phenomenological background for the subject of radiation damage. Chapters 3-6 are devoted to RPV steels and chapters 7-9 to zirconium alloys, analyzing their radiation damage structure, changes of mechanical properties due to neutron irradiation as well as factors influencing the degree of their performance degradation. The recovery of damaged materials is also discussed. Considerable attention is paid to a comparison of VVER-type and western-type light-water materials

  16. Zerumbone, a Bioactive Sesquiterpene, Ameliorates Diabetes-Induced Retinal Microvascular Damage through Inhibition of Phospho-p38 Mitogen-Activated Protein Kinase and Nuclear Factor-κB Pathways

    Directory of Open Access Journals (Sweden)

    Wayne Young Liu

    2016-12-01

    Full Text Available Zerumbone ameliorates retinal damage by blocking advanced glycation end products and their receptor system in streptozotocin-diabetic rats. Because of the multiple factors involved in diabetic retinopathy (DR etiology, the mechanisms of zerumbone that are mainly responsible for its ameliorative effect on DR need to be further clarified. In the present study, zerumbone (20 mg or 40 mg/kg or fenofibric acid (100 mg/kg was orally administered to diabetic rats by intragastric gavage once daily for three consecutive months. Zerumbone displayed similar characteristics to fenofibric acid in reducing retinal vascular permeability and leukostasis in diabetic rats. Fundus photographs showed that large retinal vessel diameters were decreased in zerumbone-treated diabetic rats. Zerumbone not only down-regulated the gene expression of retinal angiogenic parameters, but also reduced the expression of inflammatory cytokines and chemokines in the retina of diabetic rats. Moreover, zerumbone reduced the p38 MAPK phosphorylation and abrogated the nuclear translocation of NF-κB p65 in the retina of diabetic rats. In conclusion, treatment of diabetic rats with zerumbone attenuates the severity of retinal inflammation and angiogenesis, via inhibition of p38 MAPK and NF-κB signaling pathways. These benefits of zerumbone for DR appear to be linked to its antihyperglycemic and antihyperlipidemic effects.

  17. Nuclear energy and society

    International Nuclear Information System (INIS)

    Bakacs, Istvan; Czeizel, Endre; Hajdu, Janos; Marx, Gyoergy.

    1984-01-01

    The text of a round-table discussion held on the occasion of the 50th anniversary of the discovery of neutron is given. The participants were the Chief Engineer of the Paks Nuclear Power Plant, the first nuclear power plant in Hungary started in November 1982, a geneticist treating the problems of genetic damages caused by nuclear and chemical effects, a nuclear physicist and a journalist interested in the social aspects of nuclear energy. They discussed the political, economical and social problems of nuclear energy in the context of its establishment in Hungary. (D.Gy.)

  18. Risks and nuclear insurance

    International Nuclear Information System (INIS)

    Debaets, M.; Springett, G.D.; Luotonen, K.; Virole, J.

    1988-01-01

    When analysing the nuclear insurance market, three elements must be taken into account: the nuclear operator's liability is regulated by national laws and/or international Conventions, such operators pay large premiums to insure their nuclear installations against property damage and finally, the nuclear insurance market is made up of pools and is mainly a monopoly. This report describes the different types of insurance coverage, the system governing nuclear third party liability under the Paris Convention and the Brussels Supplementary Convention and several national laws in that field. The last part of the report deals with liability and insurance aspects of international transport of nuclear materials [fr

  19. Nuclear insurance

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    The yearbook contains among others the figures of the nuclear insurance line. According to these these the DKVG (German nuclear power plant insurance association) has 102 member insurance companies all registered in the Federal Republic of Germany. By using reinsurance capacities of the other pools at present property insurance amounts to 1.5 billion DM and liability insurance to 200 million DM. In 1991 the damage charges on account of DKV amounted to 3.1 (1990 : 4.3) million DM. From these 0.6 million DM are apportioned to payments and 2.5 million DM to reserves. One large damage would cost a maximum gross sum of 2.2 billion DM property and liability insurance; on account of DKVG 750 million DM. (orig./HSCH) [de

  20. Report of the U.S. Nuclear Regulatory Commission Piping Review Committee. Summary and evaluation of historical strong-motion earthquake seismic response and damage to aboveground industrial piping

    International Nuclear Information System (INIS)

    1985-04-01

    The primary purpose of this report is to collect in one reference document the observation and experience that has been developed with regard to the seismic behavior of aboveground, building-supported, industrial-type process piping (similar to piping used in nuclear power plants) in strong-motion earthquakes. The report will also contain observations regarding the response of piping in strong-motion experimental tests and appropriate conclusions regarding the behavior of such piping in large earthquakes. Recommendations are included covering the future design of such piping to resist earthquake motion damage based on observed behavior in large earthquakes and simulated shake table testing. Since available detailed data on the behavior of aboveground (building-supported) piping are quite limited, this report will draw heavily on the observations and experiences of experts in the field. In Section 2 of this report, observed earthquake damage to aboveground piping in a number of large-motion earthquakes is summarized. In Section 3, the available experience from strong-motion testing of piping in experimental facilities is summarized. In Section 4 are presented some observations that attempt to explain the observed response of piping to strong-motion excitation from actual earthquakes and shake table testing. Section 5 contains the conclusions based on this study and recommendations regarding the future seismic design of piping based on the observed strong-motion behavior and material developed for the NPC Piping Review Committee. Finally, in Section 6 the references used in this study are presented. It should be understood that the use of the term piping in this report, in general, is limited to piping supported by building structures. It does not include behavior of piping buried in soil media. It is believed that the seismic behavior of buried piping is governed primarily by the deformation of the surrounding soil media and is not dependent on the inertial response

  1. Plan and reports of coupled irradiation (JRR-3 and JOYO of research reactors) and hot facilities work (WASTEF, JMTR-HL, MMF and FMF). R and D project on irradiation damage management technology for structural materials of long-life nuclear plant

    International Nuclear Information System (INIS)

    Matsui, Yoshinori; Yamamoto, Masaya; Yoshitake, Tsunemitsu; Yoshikawa, Katsunori; Iwamatsu, Shigemi; Ichikawa, Shoichi; Yamagata, Ichiro; Soga, Tomonori; Yonekawa, Minoru; Kitamura, Ryoichi; Miyake, Osamu; Takahashi, Hiroyuki; Ishikawa, Kazuyoshi; Kikuchi, Taiji; Usami, Koji; Endo, Shinya; Ichise, Kenichi; Numata, Masami; Onozawa, Atsushi; Aizawa, Masao; Kusunoki, Tsuyoshi; Nakata, Masahito; Abe, Kazuyuki; Ito, Kazuhiro; Takaya, Shigeru; Nagae, Yuji; Wakai, Eiichi; Aoto, Kazumi

    2010-03-01

    'R and D Project on Irradiation Damage Management Technology for Structural Materials of Long-life Nuclear Plant' was carried out from FY2006 in a fund of a trust enterprise of the Ministry of Education, Culture, Sports, Science and Technology. The coupled irradiations or single irradiation by JOYO fast reactor and JRR-3 thermal reactor were performed for about two years. The irradiation specimens are very important materials to establish of 'Evaluation of Irradiation Damage Indicator' in this research. For the acquisition of the examination specimens irradiated by the JOYO and JRR-3, we summarized about the overall plan, the work process and the results for the study to utilize these reactors and some facilities of hot laboratory (WASTEF, JMTR-HL, MMF and FMF) of the Oarai Research and Development Center and the Nuclear Science Research Institute in the Japan Atomic Energy Agency. (author)

  2. Civil Liability for Nuclear Damage. Official Records

    International Nuclear Information System (INIS)

    1964-01-01

    These Official Records of the Conference contain the summary records of the plenary meetings and of the meetings of the Committee of the Whole, the text of the Convention, the Optional Protocol, the Final Act, the resolutions adopted by the Conference and the reports of the committees and sub-committees, as well as all other documents which were submitted to the plenary and the Committee of the Whole. These Official Records also contain a complete index of documents relevant to each Article of the Convention according to its number in the final text. The history of the preparatory studies and documents is summarized on pages 39, 40 and 65-86. The symbols of International Atomic Energy Agency documents are composed of capital letters combined with figures. Mention of such a symbol indicates a reference to an International Atomic Energy Agency document. The summary records of the plenary meetings and of the meetings of the Committee of the Whole contained in this volume were originally circulated in mimeographed form as documents CN-12/OR/1 to 7 and CN-12, CW/OR. 1 to 24 respectively. As printed in this volume they include the corrections to the provisional summary records that were requested by the delegations and such drafting and editorial changes as were considered necessary. These official records are available in English, French, Russian and Spanish. (author)

  3. Damage analysis: damage function development and application

    International Nuclear Information System (INIS)

    Simons, R.L.; Odette, G.R.

    1975-01-01

    The derivation and application of damage functions, including recent developments for the U.S. LMFBR and CTR programs, is reviewed. A primary application of damage functions is in predicting component life expectancies; i.e., the fluence required in a service spectrum to attain a specified design property change. An important part of the analysis is the estimation of the uncertainty in such fluence limit predictions. The status of standardizing the procedures for the derivation and application of damage functions is discussed. Improvements in several areas of damage function development are needed before standardization can be completed. These include increasing the quantity and quality of the data used in the analysis, determining the limitations of the analysis due to the presence of multiple damage mechanisms, and finally, testing of damage function predictions against data obtained from material surveillance programs in operating thermal and fast reactors. 23 references. (auth)

  4. Radiation-damage calculations with NJOY

    International Nuclear Information System (INIS)

    MacFarlane, R.E.; Muir, D.W.; Mann, F.W.

    1983-01-01

    Atomic displacement, gas production, transmutation, and nuclear heating can all be calculated with the NJOY nuclear data processing system using evaluated data in ENDF/B format. Using NJOY helps assure consistency between damage cross sections and those used for transport, and NJOY provides convenient interface formats for linking data to application codes. Unique features of the damage calculation include a simple momentum balance treatment for radiative capture and a new model for (n, particle) reactions based on statistical model calculations. Sample results for iron and nickel are given and compared with the results of other methods

  5. In-pool damaged fuel bundle recovery

    International Nuclear Information System (INIS)

    Piascik, T.G.; Patenaude, R.S.

    1988-01-01

    While preparing to rerack the Oyster Creek Nuclear Generating Station, GPU Nuclear had need to move a damaged fuel bundle. This bundle had no upper tie plate and could not be moved in the normal manner. GPU Nuclear formed a small, dedicated project team to disassemble, package and move this damaged bundle. The team was composed of key personnel from GPU Nuclear Fuels Projects, OCNGS Operations and Proto-Power / Bisco, a specialty contractor who has fuel bundle reconstitution and rod consolidation experience, remote tooling, underwater video systems and experienced technicians. Proven tooling, clear procedures and a simple approach were important, but the key element was the spirit of teamwork and leadership exhibited by the people involved

  6. In-pool damaged fuel bundle recovery

    International Nuclear Information System (INIS)

    Piascik, T.G.; Patenaude, R.S.

    1988-01-01

    While preparing to rerack the Oyster Creek Nuclear Generating Station, GPU Nuclear had need to move a damaged fuel bundle. This bundle had no upper tie plate and could not be moved in the normal manner. GPU Nuclear formed a small, dedicated project team to disassemble, package, and move this damaged bundle. The team was composed of key personnel from GPU Nuclear Fuels Projects, OCNGS Operations and Proto-Power/Bisco, a specialty contractor who has fuel bundle reconstitution and rod consolidation experience, remote tooling, underwater video systems and experienced technicians. Proven tooling, clear procedures and a simple approach were important, but the key element was the spirit of teamwork and leadership exhibited by the people involved. In spite of several emergent problems which a task of this nature presents, this small, close knit utility/vendor team completed the work on schedule and within the exposure and cost budgets

  7. Nuclear Hostages

    International Nuclear Information System (INIS)

    Cooper, C.L.

    1978-01-01

    The global spread of nuclear reactors for the production of energy seems inevitable. Nuclear power plants will be supplied--if not by the United States, then by one of several other exporters. But other aspects of this development are less certain. One is the relationship between proliferation of nuclear energy plants and that of nuclear weapons. Another is the actual constraint that such vulnerable potential targets as nuclear power plants would have on would-be aggressors. In the last analysis, this would depend on the rationality of a nation's leadership. What can be said for the concept of nuclear power plants as potential hostages is that by installing a reactor on its territory, a country increases its vulnerability to grave, possibly unacceptable damage in the event of war. As a result, that nation's leaders might be inclined to raise the threshold of their sensitivity to provocation by neighbors and to restrain their own inclinations toward aggression. Admittedly this is a frail substitute for robust international agreements, but in the present order of things it is not a trivial consideration. Many incidents once regarded by the great powers as easi belli have more recently been either resolved by diplomacy or ignored altogether. The idea must not be pressed too far. The export of a nuclear power plant to a Third World country cannot be advocated simply as a means to constrain its own military adventurism. Aside from the promise of a vast increase in energy supply for developing nations, nuclear powered generating stations could actually improve relations among countries. The risk of widespread radioactive contamination by nuclear power plants hit by even conventional bombs could introduce a positive new element into the military calculations of powers outside the NATO-Warsaw Pact arena. As they balance military and diplomatic solutions to local conflicts, moderation rather than bellicosity might become the better part of valor

  8. The energy overcompensating disintegrations of residual target nuclei damaged in hadron-nucleus collisions

    International Nuclear Information System (INIS)

    Strugalski, Z.

    1995-01-01

    Massive target nuclei damaged in hadron-nucleus collisions at high energies are used to disintegrate into nuclear fragments. In many cases such breakup is egzoergic - some portion of nuclear energy is released; this portion should be overcompensating the energy used for the nuclear damage, in some cases. 30 refs

  9. Radiation damage of nonmetallic solids

    International Nuclear Information System (INIS)

    Goland, A.N.

    1975-01-01

    A review of data and information on radiation damage in nonmetallic solids is presented. Discussions are included on defects in nonmetals, radiation damage processes in nonmetals, electronic damage processes, physical damage processes, atomic displacement, photochemical damage processes, and ion implantation

  10. Damages by radiation in glasses

    International Nuclear Information System (INIS)

    Olguin, F.; Gutierrez, C.; Cisniega, G.; Flores, J.H.; Golzarri, J.I.; Espinoza, G.

    1997-01-01

    As a part of the works carried out to characterize the electrons beam from the Pelletron accelerator of the Mexican Nuclear Center aluminium-silicate glass samples were irradiated. The purpose of these irradiations is to cause alterations in the amorphous microstructure of the material by means of the creation of color centers. The population density of these defects, consequence to the irradiation, is function of the exposure time which varied from 1 to 30 minutes, with an electronic beam energy of 400 keV, doing the irradiations at free atmosphere. the obtained spectra are correlated by damage which the radiation produced. (Author)

  11. Femoral nerve damage (image)

    Science.gov (United States)

    The femoral nerve is located in the leg and supplies the muscles that assist help straighten the leg. It supplies sensation ... leg. One risk of damage to the femoral nerve is pelvic fracture. Symptoms of femoral nerve damage ...

  12. Continuum damage mechanics method for fatigue growth of surface cracks

    International Nuclear Information System (INIS)

    Feng Xiqiao; He Shuyan

    1997-01-01

    With the background of leak-before-break (LBB) analysis of pressurized vessels and pipes in nuclear plants, the fatigue growth problem of either circumferential or longitudinal semi-elliptical surface cracks subjected to cyclic loading is studied by using a continuum damage mechanics method. The fatigue damage is described by a scalar damage variable. From the damage evolution equation at the crack tip, a crack growth equation similar to famous Paris' formula is derived, which shows the physical meaning of Paris' formula. Thereby, a continuum damage mechanics approach is developed to analyze the configuration evolution of surface cracks during fatigue growth

  13. Nuclear liability act and nuclear insurance

    International Nuclear Information System (INIS)

    Clarke, Roy G.; Goyette, R.; Mathers, C.W.; Germani, T.R.

    1976-01-01

    The Nuclear Liability Act, enacted in June 1970 and proclaimed effective October 11, 1976, is a federal law governing civil liability for nuclear damage in Canada incorporating many of the basic principles of the international conventions. Exceptions to operator liability for breach of duty imposed by the Act and duty of the operator as well as right of recourse, time limit on bringing actions, special measures for compensation and extent of territory over which the operator is liable are of particular interest. An operator must maintain $75,000,000. of insurance for each nuclear installation for which he is the operator. The Nuclear Insurance Association of Canada (NIAC) administers two ΣPoolsΣ or groups of insurance companies where each member participates for the percentage of the total limit on a net basis, one pool being for Physical Damage Insurance and the other for Liability Insurance. The Atomic Energy Control Board recommends to the Treasury Board the amount of insurance (basic) for each installation. Basic insurance required depends on the exposure and can range from $4 million for a fuel fabricator to $75 million for a power reactor. Coverage under the Operator's Policy provides for bodily injury, property damage and various other claims such as damage from certain transportation incidents as well as nuclear excursions. Workmen's Compensation will continue to be handled by the usual channels. (L.L.)

  14. Simulation study of radiation damage induced by energetic helium nuclei

    International Nuclear Information System (INIS)

    Hoang Dac Luc; Vo Tuong Hanh; Hoang Dac Dat

    2003-01-01

    High energy alpha particles produced by neutron-induced nuclear reactions can damage severely reactor materials. Simulation of this process is described using theoretical calculation and ion irradiation experiments at different displacement doses and Helium doses. (author)

  15. Simulation study of radiation damage induced by energetic helium nuclei

    CERN Document Server

    Hoang Dac Luc; Hoang Dac Dat

    2003-01-01

    High energy alpha particles produced by neutron-induced nuclear reactions can damage severely reactor materials. Simulation of this process is described using theoretical calculation and ion irradiation experiments at different displacement doses and Helium doses.

  16. DNA damage in plant herbarium tissue.

    Science.gov (United States)

    Staats, Martijn; Cuenca, Argelia; Richardson, James E; Vrielink-van Ginkel, Ria; Petersen, Gitte; Seberg, Ole; Bakker, Freek T

    2011-01-01

    Dried plant herbarium specimens are potentially a valuable source of DNA. Efforts to obtain genetic information from this source are often hindered by an inability to obtain amplifiable DNA as herbarium DNA is typically highly degraded. DNA post-mortem damage may not only reduce the number of amplifiable template molecules, but may also lead to the generation of erroneous sequence information. A qualitative and quantitative assessment of DNA post-mortem damage is essential to determine the accuracy of molecular data from herbarium specimens. In this study we present an assessment of DNA damage as miscoding lesions in herbarium specimens using 454-sequencing of amplicons derived from plastid, mitochondrial, and nuclear DNA. In addition, we assess DNA degradation as a result of strand breaks and other types of polymerase non-bypassable damage by quantitative real-time PCR. Comparing four pairs of fresh and herbarium specimens of the same individuals we quantitatively assess post-mortem DNA damage, directly after specimen preparation, as well as after long-term herbarium storage. After specimen preparation we estimate the proportion of gene copy numbers of plastid, mitochondrial, and nuclear DNA to be 2.4-3.8% of fresh control DNA and 1.0-1.3% after long-term herbarium storage, indicating that nearly all DNA damage occurs on specimen preparation. In addition, there is no evidence of preferential degradation of organelle versus nuclear genomes. Increased levels of C→T/G→A transitions were observed in old herbarium plastid DNA, representing 21.8% of observed miscoding lesions. We interpret this type of post-mortem DNA damage-derived modification to have arisen from the hydrolytic deamination of cytosine during long-term herbarium storage. Our results suggest that reliable sequence data can be obtained from herbarium specimens.

  17. Nuclear energy

    International Nuclear Information System (INIS)

    Anon.

    1994-01-01

    The Administrative Court of Braunschweig judges the Ordinance on Advance Funding of Repositories (EndlagervorausleistungsVO) to be void. The Hannover Regional Court passes a basic judgment concerning the Gorleben salt mine (repository) and an action for damages. The Federal Administrative Court dismisses actions against part-permits for the Hanau fuel element fabrication plant. The Koblenz Higher Administrative Court dismisses actions against a part-permit for the Muelheim-Kaerlich reactor. 31st Amendment of the German Criminal Code passed, involving amendments in environmental criminal code, defined in the 2nd amendment to the Act on Unlowful Practices Causing Damage to the Environment (UKG); here: Amendments to the law relating to the criminal code and penal provisions governing unlawful conduct in the operation of nuclear installations. (orig.) [de

  18. Nuclear energy and nuclear technology

    International Nuclear Information System (INIS)

    Luescher, E.

    1982-01-01

    This book originated in the training courses for teachers of grammar- and secondary schools in Dillingen (Bavaria). The aim of these courses is to become informed about the latest state in one field of physics. The lectures are well-known experts in the respective fields. In the latest study (1980) of the National Academy of Sciences the experts came to the conclusion that without further development nuclear power plants the utilization of too much coal would become necessary and involve irreversible environmental damage (see chapter 6). There are two important obstacles impeding the further extension of nuclear energy. The first problem to be solved is the processing and storage of radioactive waste. This is a more technical task and can be treated in a satisfactory way. The second obstacle is less easy to take as the population has to be convinced that a nuclear power plant can be operated with almost unbelievable safety (see chapter 5) and be shut down safely in the case of incidents. The most promising possibility of controlled nuclear fusion as energy source is still many decades- if feasible at all- away from being performed (see chapter. 7). In the Soviet Union 25% of the electric energy production shall be proceed from nuclear power plants by the year 1990. (orig./GL) [de

  19. Air pollution and brain damage.

    Science.gov (United States)

    Calderón-Garcidueñas, Lilian; Azzarelli, Biagio; Acuna, Hilda; Garcia, Raquel; Gambling, Todd M; Osnaya, Norma; Monroy, Sylvia; DEL Tizapantzi, Maria Rosario; Carson, Johnny L; Villarreal-Calderon, Anna; Rewcastle, Barry

    2002-01-01

    Exposure to complex mixtures of air pollutants produces inflammation in the upper and lower respiratory tract. Because the nasal cavity is a common portal of entry, respiratory and olfactory epithelia are vulnerable targets for toxicological damage. This study has evaluated, by light and electron microscopy and immunohistochemical expression of nuclear factor-kappa beta (NF-kappaB) and inducible nitric oxide synthase (iNOS), the olfactory and respiratory nasal mucosae, olfactory bulb, and cortical and subcortical structures from 32 healthy mongrel canine residents in Southwest Metropolitan Mexico City (SWMMC), a highly polluted urban region. Findings were compared to those in 8 dogs from Tlaxcala, a less polluted, control city. In SWMMC dogs, expression of nuclear neuronal NF-kappaB and iNOS in cortical endothelial cells occurred at ages 2 and 4 weeks; subsequent damage included alterations of the blood-brain barrier (BBB), degenerating cortical neurons, apoptotic glial white matter cells, deposition of apolipoprotein E (apoE)-positive lipid droplets in smooth muscle cells and pericytes, nonneuritic plaques, and neurofibrillary tangles. Persistent pulmonary inflammation and deteriorating olfactory and respiratory barriers may play a role in the neuropathology observed in the brains of these highly exposed canines. Neurodegenerative disorders such as Alzheimer's may begin early in life with air pollutants playing a crucial role.

  20. Using NJOY99 and MCNP4B2 to Estimate the Radiation Damage Displacements per Atom per Second in Steel Within the Boiling Water Reactor Core Shroud and Vessel Wall from Reactor-Grade Mixed-Oxide/Uranium Oxide Fuel for the Nuclear Power Plant at Laguna Verde, Veracruz, Mexico

    International Nuclear Information System (INIS)

    Vickers, Lisa

    2003-01-01

    The government of Mexico has expressed interest in utilizing the Laguna Verde boiling water reactor (BWR) nuclear power plant for the disposition of reprocessed spent uranium oxide (UOX) fuel in the form of reactor-grade mixed-oxide (MOX) fuel. MOX fuel would replace spent UOX fuel as a fraction in the core from 18 to 30% depending on the fuel loading cycle. MOX fuel is expected to increase the neutron fluence, flux, fuel centerline temperature, reactor core pressure, and yield higher energy neutrons.There is concern that a core with a fraction of MOX fuel (i.e., increased 239 Pu wt%) would increase the radiation damage displacements per atom per second (dpa-s -1 ) in steel within the core shroud and vessel wall as compared to only conventional, enriched UOX fuel in the core. The evaluation of radiation damage within the core shroud and vessel wall is a concern because of the potentially adverse affect to personnel and public safety, environment, and operating life of the reactor.The primary uniqueness of this paper is the computation of radiation damage (dpa-s -1 ) using NJOY99-processed cross sections for steel within the core shroud and vessel wall. Specifically, the unique radiation damage results are several orders of magnitude greater than results of previous works. In addition, the conclusion of this paper was that the addition of the maximum fraction of one-third MOX fuel to the LV1 BWR core did significantly increase the radiation damage in steel within the core shroud and vessel wall such that without mitigation of radiation damage by periodic thermal annealing or reduction in operating parameters such as neutron fluence, core temperature, and pressure, it posed a potentially adverse affect to the personnel and public safety, environment, and operating life of the reactor

  1. Development of international law concerning nuclear liability

    International Nuclear Information System (INIS)

    Ifflaender, G.; Kantner, G.

    1979-01-01

    A short overview is given of the most important international conventions relating to civil liability for damage to, or loss of, life of persons or property, caused by nuclear incidents during the operation of stationary and non-stationary nuclear installations or transport of nuclear material. In accord with the international provisions, in the German Democratic Republic too, nuclear operators are exclusively liable for such damage unless it has been caused intentionally by the injury party. (author)

  2. Macroscopic morphology of radiation damage in copper

    International Nuclear Information System (INIS)

    Black, K.E.

    1977-01-01

    This Thesis describes the damage produced in copper single crystals when they are irradiated with neutrons from a nuclear reactor, and shows that the morphology of the damage is dependent on the temperature of irradiation. The production of point defects in the initial stages of the bombardment and their subsequent diffusion is described in Chapter One. Chapter Two describes the techniques used to etch and thus make visible the damage regions. The defect clusters were examined with a microscope. A typical selection of micrographs of the damage is presented and discussed in Chapter Three. In the final chapter, Chapter Four, the results of the present work are discussed in the light of work done by other research workers. The Thesis ends with a brief suggestion for future work to be carried out on neutron irradiated copper single crystals

  3. 3D cellular automata finite element (CAFE) modelling and experimental observation of damage in quasi-brittle nuclear materials: Indentation of a SiC-SiC-fibre ceramic matrix composite

    International Nuclear Information System (INIS)

    Saucedo Mora, Luis; Mostafavi, Mahmoud; Marrow, T. James; Khoshkhou, Danial; Connolly, Brian; Reinhard, Christina; Atwood, Robert; Zhao, Shuang

    2015-01-01

    Cellular automata integrated with finite elements (CAFE) have been used to develop a method to account for the effect of microstructure on quasi-brittle damage development. The microstructure is simulated explicitly by subdividing a finite element into smaller cells. A heterogeneous structure is created from key cells (seeds) using defined characteristics; the influence of the initial finite element mesh is effectively removed during the development of the microstructure. Graded microstructures, textures, particle anisotropy and multiple phases can be readily simulated, such as those in composites and porous materials. A mesh-free framework has been developed to compute the damage development through the microstructure, using cellular automata. With this method, we can study the development of discontinuous cracking and damage coalescence, and its sensitivity to microstructure. Experiments have been carried out to observe the three-dimensional development of damage, using high-resolution synchrotron X-ray computed tomography and digital volume correlation to observe Hertzian indentation of a SiC-SiC fibre composite, quantifying damage by measurement of the displacement fields within the material. The results demonstrate the applicability of the modelling strategy to damage development, and show how model input data may be obtained from small specimen tests, which could be performed at elevated temperatures with irradiated materials. (authors)

  4. Continuum Damage Mechanics A Continuum Mechanics Approach to the Analysis of Damage and Fracture

    CERN Document Server

    Murakami, Sumio

    2012-01-01

    Recent developments in engineering and technology have brought about serious and enlarged demands for reliability, safety and economy in wide range of fields such as aeronautics, nuclear engineering, civil and structural engineering, automotive and production industry.  This, in turn, has caused more interest in continuum damage mechanics and its engineering applications.   This book aims to give a concise overview of the current state of damage mechanics, and then to show the fascinating possibility of this promising branch of mechanics, and to provide researchers, engineers and graduate students with an intelligible and self-contained textbook.   The book consists of two parts and an appendix.  Part I  is concerned with the foundation of continuum damage mechanics.  Basic concepts of material damage and the mechanical representation of damage state of various kinds are described in Chapters 1 and 2.  In Chapters 3-5, irreversible thermodynamics, thermodynamic constitutive theory and its application ...

  5. Reflection on penal policy in nuclear matters

    International Nuclear Information System (INIS)

    Cisse, A.

    1996-01-01

    This document expresses ethical reflexions as far as nuclear energy development is concerned. The potential diversion of the peaceful use of nuclear energy results in the necessity of a criminal policy which would control the nuclear regulations. For each potential nuclear infringement, systems of laws are established either to prevent damages or to penalize them. (TEC)

  6. Nuclear insurance fire risk

    International Nuclear Information System (INIS)

    Dressler, E.G.

    2001-01-01

    Nuclear facilities operate under the constant risk that radioactive materials could be accidentally released off-site and cause injuries to people or damages to the property of others. Management of this nuclear risk, therefore, is very important to nuclear operators, financial stakeholders and the general public. Operators of these facilities normally retain a portion of this risk and transfer the remainder to others through an insurance mechanism. Since the nuclear loss exposure could be very high, insurers usually assess their risk first-hand by sending insurance engineers to conduct a nuclear insurance inspection. Because a serious fire can greatly increase the probability of an off-site release of radiation, fire safety should be included in the nuclear insurance inspection. This paper reviews essential elements of a facility's fire safety program as a key factor in underwriting nuclear third-party liability insurance. (author)

  7. Lessons from nuclear disasters

    International Nuclear Information System (INIS)

    Shigematsu, Itsuzo

    2005-01-01

    The most severe and worst of all nuclear disasters is, needless to say, the explosion of an atomic bomb. The WHO committee on the effects of nuclear war, established in 1982, concluded that the only approach to the treatment of the health effects of nuclear warfare is primary prevention, that is, the prevention of nuclear war. Nuclear disasters have also occurred in nuclear power plants and nuclear facilities, causing various damage and acute anxiety among the workers and general public, but thus far the related health effects have not always been correctly evaluated. Such problems as exposed population, individual exposed dose and health risks which are associated with these evaluation efforts are discussed here. (author)

  8. Nuclear safety and nuclear insurance

    International Nuclear Information System (INIS)

    Abramovitz, A.

    1983-01-01

    To an extent, public opinion is against Koeberg, inspite of the fact that Escom, Koeberg's prospective licensee, are liable for damages caused in the event of an accident, that they carry public liability insurance bought in the market place to the maximum of ten million rand, and if that is not enough the government will take over responsibility for the rest. A question is put that if this kind of protection carries on, won't there always be a minority of the public who will find nuclear power socially, psychologically and politically unacceptable

  9. Analysis of radiation damaged nanocrystals

    International Nuclear Information System (INIS)

    Sitek, J.; Dekan, J.; Sedlackova, K.; Sagatova, A.

    2014-01-01

    Ribbon-shaped specimens of the master alloy were prepared by planar flow casting. The ribbons with nominal composition of (Fe_1_-_xN_x)_8_1Nb_7B_1_2 (x = 0, 0.25, 0.5, 0.75) were about 25 μm thick and 10 mm wide. To achieve nanocrystalline state, the amorphous ribbons were annealed in vacuum at the temperature of 550 grad C for 1 hour. Samples were irradiated by neutrons in nuclear reactor with fluence of 10"1"6 n/cm"2 and 10"1"7 n/cm"2. and by electrons in linear accelerator with dose 1 MGy at the Slovak Medical University. Moessbauer spectra were collected in transmission geometry by a conventional constant-acceleration spectrometer with a "5"7Co(Rh) source. All spectra were measured at room temperature and evaluated by the CONFIT program, which allows simultaneous treatment of crystalline and residual amorphous phase by means of individual lines and distribution of hyperfine components. After summarizing all obtained results, the fluence 10"1"6 n/cm"2 is still not sufficiently high significantly damage amorphous and crystalline structure. This fluence more or less modify the structure than damage. After fluence 10"17"n/cm"2 we observed beginning of the. structural damage. Our results show, that high electron dose also modify the structure of nanocrystaline alloys. In further study of this alloy it would be necessary to find the limit of electron dose under that the alloy is resistant against electron's damage. From point of view Moessbauer spectroscopy the most sensitive parameter is direction of net magnetic moment. (authors)

  10. Nuclear law - Nuclear safety

    International Nuclear Information System (INIS)

    Pontier, Jean-Marie; Roux, Emmanuel; Leger, Marc; Deguergue, Maryse; Vallar, Christian; Pissaloux, Jean-Luc; Bernie-Boissard, Catherine; Thireau, Veronique; Takahashi, Nobuyuki; Spencer, Mary; Zhang, Li; Park, Kyun Sung; Artus, J.C.

    2012-01-01

    This book contains the contributions presented during a one-day seminar. The authors propose a framework for a legal approach to nuclear safety, a discussion of the 2009/71/EURATOM directive which establishes a European framework for nuclear safety in nuclear installations, a comment on nuclear safety and environmental governance, a discussion of the relationship between citizenship and nuclear, some thoughts about the Nuclear Safety Authority, an overview of the situation regarding the safety in nuclear waste burying, a comment on the Nome law with respect to electricity price and nuclear safety, a comment on the legal consequences of the Fukushima accident on nuclear safety in the Japanese law, a presentation of the USA nuclear regulation, an overview of nuclear safety in China, and a discussion of nuclear safety in the medical sector

  11. Nuclear Liability Legislation in Slovenia

    International Nuclear Information System (INIS)

    Skraban, A.

    1998-01-01

    This paper reviews Slovenian national legislation in the field of third party liability for nuclear damage, applicability of the international nuclear liability treaties in Slovenia legal system and outlines some main provisions of national legislation. It is worth mentioning that legal instruments covering third party liability and compulsory insurance of such liability exist in Slovenia for almost 20 years and that our nuclear facilities are covered by relevant international treaties and conventions in this field, among them also by the Vienna Convention on Civil Liability for Nuclear Damage (from 1977) and the Joint Protocol Relating to the Application of the Vienna Convention and the Paris Convention (from 1994). (author)

  12. Seismic damage assessment of reinforced concrete containment structures

    International Nuclear Information System (INIS)

    Cho, HoHyun; Koh, Hyun-Moo; Hyun, Chang-Hun; Kim, Moon-Soo; Shin, Hyun Mock

    2003-01-01

    This paper presents a procedure for assessing seismic damage of concrete containment structures using the nonlinear time-history numerical analysis. For this purpose, two kinds of damage index are introduced at finite element and structural levels. Nonlinear finite element analysis for the containment structure applies PSC shell elements using a layered approach leading to damage indices at finite element and structural levels, which are then used to assess the seismic damage of the containment structure. As an example of such seismic damage assessment, seismic damages of the containment structure of Wolsong I nuclear power plant in Korea are evaluated against 30 artificial earthquakes generated with a wide range of PGA according to US NRC regulatory guide 1.60. Structural responses and corresponding damage index according to the level of PGA and nonlinearity are investigated. It is also shown that the containment structure behaves elastically for earthquakes corresponding to or lower than DBE. (author)

  13. Nuclear liability legislation in Slovenia

    International Nuclear Information System (INIS)

    Skraban, A.

    2000-01-01

    This paper gives some basic data about nuclear installations in Slovenia, reviews Slovenian national legislation in the field of third-party liability for nuclear damage, applicability of the international nuclear liability treaties in the Slovenian legal system and outlines some main provisions of national legislation. It also aims to give some facts about history and present status of nuclear insurance pool and the insurance of nuclear risks in Slovenia. Paper finally indicates also some future legislative steps with respect to nuclear third party liability, at national and international level. (author)

  14. Creep-fatigue damage under multiaxial conditions

    International Nuclear Information System (INIS)

    Lobitz, D.W.; Nickell, R.E.

    1977-02-01

    ASME Code rules for design against creep-fatigue damage for Class 1 nuclear components operating at elevated temperatures are currently being studied by ASME working groups and task forces with a view toward major modification. In addition, the design rules being developed for Class 2 and Class 3 components would be affected by any major modifications of Class 1 Rules. The report represents an attempt to evaluate the differences between two competing procedures--linear damage summation and strainrange partitioning--for multiaxial stress conditions. A modified version of strainrange partitioning is also developed to alleviate some limitations on nonproportional loading

  15. Radiation damage to mushrooms

    International Nuclear Information System (INIS)

    Sattler, P.W.

    1986-01-01

    This document contains newspaper cuttings and correspondence with various ministries in Hessen on the subject of radiation damage to mushrooms from the Odenwald area. The reader is given, amongst other things, detailed information on radiation damage to different types of mushroom in 1986. (MG) [de

  16. Animal damage to birch

    Science.gov (United States)

    James S. Jordan; Francis M. Rushmore

    1969-01-01

    A relatively few animal species are responsible for most of the reported damage to the birches. White-tailed deer, yellow-bellied sapsuckers, porcupines, moose, and hares are the major animals involved. We will review reports of damage, discuss the underlying causes, and describe possible methods of control. For example, heavy deer browsing that eliminates birch...

  17. Animal damage management handbook.

    Science.gov (United States)

    Hugh C. Black

    1994-01-01

    This handbook treats animal damage management (ADM) in the West in relation to forest, range, and recreation resources; predator management is not addressed. It provides a comprehensive reference of safe, effective, and practical methods for managing animal damage on National Forest System lands. Supporting information is included in references after each chapter and...

  18. DNA damage and autophagy

    International Nuclear Information System (INIS)

    Rodriguez-Rocha, Humberto; Garcia-Garcia, Aracely; Panayiotidis, Mihalis I.; Franco, Rodrigo

    2011-01-01

    Both exogenous and endogenous agents are a threat to DNA integrity. Exogenous environmental agents such as ultraviolet (UV) and ionizing radiation, genotoxic chemicals and endogenous byproducts of metabolism including reactive oxygen species can cause alterations in DNA structure (DNA damage). Unrepaired DNA damage has been linked to a variety of human disorders including cancer and neurodegenerative disease. Thus, efficient mechanisms to detect DNA lesions, signal their presence and promote their repair have been evolved in cells. If DNA is effectively repaired, DNA damage response is inactivated and normal cell functioning resumes. In contrast, when DNA lesions cannot be removed, chronic DNA damage triggers specific cell responses such as cell death and senescence. Recently, DNA damage has been shown to induce autophagy, a cellular catabolic process that maintains a balance between synthesis, degradation, and recycling of cellular components. But the exact mechanisms by which DNA damage triggers autophagy are unclear. More importantly, the role of autophagy in the DNA damage response and cellular fate is unknown. In this review we analyze evidence that supports a role for autophagy as an integral part of the DNA damage response.

  19. Transport Nuclear Liability Insurance

    International Nuclear Information System (INIS)

    Folens, M.

    2006-01-01

    Although transport of nuclear substances represents only a very small part of the global transport of dangerous goods, it takes place every day all over the world and it is part of our daily life. Transport of nuclear material takes also place at every stage of the nuclear fuel cycle; radioactive materials are carried out all over the world by all major modes of transport: sea, air, road and rail. Despite the large number of nuclear transports, they are not considered as posing a serious risk. A major nuclear incident is almost always associated with the operating of fixed installations such as nuclear power plants; just think about Three Mile Island and Chernobyl. This perception is strengthened by the absence so far of serious accidents in the nuclear transport sector and this finding is in fact proof of the very safe conditions of nuclear transport. But accidents can never be excluded entirely and in some cases damages could be as large as those caused by fixed installations. This means that protection of the interests of possible victims should also be covered in a correct way. That is why the special nuclear liability regime has also been developed to cover damage caused by a nuclear transport accident. As stated by Patrick Reyners, the prime motivation for originally adopting a special nuclear regime was the harmonisation of national legislation and that nowhere more than in the field of international transport operations is such harmonisation felt desirable . The international legal regime has been developed along two tracks, one based on the mode of transport and the other based on the notion of dangerous goods. The linkage between those two tracks is of permanent concern and the mode of transport is the key element to determine which international instrument should be applicable. The purpose of this paper is to briefly introduce the financial security provided by the insurance industry to cover the international nuclear liability regime for nuclear

  20. Bruce B fuelling-with-flow operations: fuel damage investigation

    Energy Technology Data Exchange (ETDEWEB)

    Manzer, A.M. [CANTECH Associates Ltd., Burlington, Ontario (Canada); Morikawa, D. [Atomic Energy of Canada Limited, Mississauga, Ontario (Canada); Hains, A.J.; Cichowlas, W.M. [Nuclear Safety Solutions Limited, Toronto, Ontario (Canada); Roberts, J.G.; Wylie, J. [Bruce Power, Ontario (Canada)

    2005-07-01

    This paper summarizes the fuel bundle damage characterization done by Nuclear Safety Solutions Limited (NSS) and the out-reactor flow visualization tests done at Atomic Energy of Canada Limited (AECL) to reproduce the damage observed on irradiated fuel bundles. The bearing pad damage mechanism was identified and the tests showed that a minor change to the fuelling sequence would eliminate the mechanical interaction. The change was implemented in January 2005. Since then, the bearing pad damage appears to have been greatly reduced based on the small number of discharged bundles inspected to date. (author)

  1. Bruce B fuelling-with-flow operations: fuel damage investigation

    International Nuclear Information System (INIS)

    Manzer, A.M.; Morikawa, D.; Hains, A.J.; Cichowlas, W.M.; Roberts, J.G.; Wylie, J.

    2005-01-01

    This paper summarizes the fuel bundle damage characterization done by Nuclear Safety Solutions Limited (NSS) and the out-reactor flow visualization tests done at Atomic Energy of Canada Limited (AECL) to reproduce the damage observed on irradiated fuel bundles. The bearing pad damage mechanism was identified and the tests showed that a minor change to the fuelling sequence would eliminate the mechanical interaction. The change was implemented in January 2005. Since then, the bearing pad damage appears to have been greatly reduced based on the small number of discharged bundles inspected to date. (author)

  2. Constructive and critical approach of the radiation damage simulation

    International Nuclear Information System (INIS)

    Becquart, Ch.

    2002-11-01

    This work deals with the problem of radiation damage in materials for applications in development of fission and nuclear fusion technologies. It is organised in 3 sections. In section 1 are presented the mechanisms of formation and the evolution kinetics of the primary damage. Section 2 is devoted to the study of the sensitivity of the radiation damage at different approximations. Section 3 discusses the contribution of the ab initio calculations to the study of radiation damage and more particularly the point defects in a dilute Fe-Cu ferritic alloy. This work is illustrated by several publications added in each section. (O.M.)

  3. Metabolite Damage and Metabolite Damage Control in Plants

    Energy Technology Data Exchange (ETDEWEB)

    Hanson, Andrew D. [Horticultural Sciences Department and; Henry, Christopher S. [Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, Illinois 60439, email:; Computation Institute, University of Chicago, Chicago, Illinois 60637; Fiehn, Oliver [Genome Center, University of California, Davis, California 95616, email:; de Crécy-Lagard, Valérie [Microbiology and Cell Science Department, University of Florida, Gainesville, Florida 32611, email: ,

    2016-04-29

    It is increasingly clear that (a) many metabolites undergo spontaneous or enzyme-catalyzed side reactions in vivo, (b) the damaged metabolites formed by these reactions can be harmful, and (c) organisms have biochemical systems that limit the buildup of damaged metabolites. These damage-control systems either return a damaged molecule to its pristine state (metabolite repair) or convert harmful molecules to harmless ones (damage preemption). Because all organisms share a core set of metabolites that suffer the same chemical and enzymatic damage reactions, certain damage-control systems are widely conserved across the kingdoms of life. Relatively few damage reactions and damage-control systems are well known. Uncovering new damage reactions and identifying the corresponding damaged metabolites, damage-control genes, and enzymes demands a coordinated mix of chemistry, metabolomics, cheminformatics, biochemistry, and comparative genomics. This review illustrates the above points using examples from plants, which are at least as prone to metabolite damage as other organisms.

  4. DNA damage and polyploidization.

    Science.gov (United States)

    Chow, Jeremy; Poon, Randy Y C

    2010-01-01

    A growing body of evidence indicates that polyploidization triggers chromosomal instability and contributes to tumorigenesis. DNA damage is increasingly being recognized for its roles in promoting polyploidization. Although elegant mechanisms known as the DNA damage checkpoints are responsible for halting the cell cycle after DNA damage, agents that uncouple the checkpoints can induce unscheduled entry into mitosis. Likewise, defects of the checkpoints in several disorders permit mitotic entry even in the presence of DNA damage. Forcing cells with damaged DNA into mitosis causes severe chromosome segregation defects, including lagging chromosomes, chromosomal fragments and chromosomal bridges. The presence of these lesions in the cleavage plane is believed to abort cytokinesis. It is postulated that if cytokinesis failure is coupled with defects of the p53-dependent postmitotic checkpoint pathway, cells can enter S phase and become polyploids. Progress in the past several years has unraveled some of the underlying principles of these pathways and underscored the important role of DNA damage in polyploidization. Furthermore, polyploidization per se may also be an important determinant of sensitivity to DNA damage, thereby may offer an opportunity for novel therapies.

  5. Project of law authorizing the approval of the agreement between the government of the French republic and the government of the Russian federation relative to the civil liability by way of nuclear damage owing to the supply of materials from the French republic devoted to nuclear facilities in the Russian federation; Projet de loi autorisant l'approbation de l'accord entre le gouvernement de la republique francaise et le gouvernement de la federation de Russie relatif a la responsabilite civile au titre de dommages nucleaires du fait de fournitures en provenance de la republique francaise destinees a des installations nucleaires en federation de Russie

    Energy Technology Data Exchange (ETDEWEB)

    Raffarin, J.P.; Villepin, D. de

    2002-07-01

    An agreement between France and Russia was signed on June 20, 2000 about the civil liability of Russia because of the supply of French material devoted to Russian nuclear facilities. This agreement was necessary because Russia do not belong to any of the two big international civil liability systems relative to nuclear energy, i.e. the Paris convention from July 29, 1960 (in the OECD framework) and the Vienna convention from May 21, 1963 (in the IAEA framework). This agreement offers a protection to the French nuclear suppliers against any damage claims in the case of a nuclear accident occurring on the Russian federation territory. This project of law aims at approving this agreement. (J.S.)

  6. Radiation damage calculations for compound materials

    International Nuclear Information System (INIS)

    Greenwood, L.R.

    1989-01-01

    Displacement damage calculations can be performed for 40 elements in the energy range up to 20 MeV with the SPECTER computer code. A recent addition to the code, called SPECOMP, can intermix atomic recoil energy distributions for any four elements to calculate the proper displacement damage for compound materials. The calculations take advantage of the atomic recoil data in the SPECTER libraries, which were determined by the DISCS computer code, using evaluated neutron cross section and angular distribution data in ENDF/B-V. Resultant damage cross sections for any compound can be added to the SPECTER libraries for the routine calculation of displacements in any given neutron field. Users do not require access to neutron cross section files. Results are presented for a variety of fusion materials and a new ceramic superconductor material. Future plans and nuclear data needs are discussed. 11 refs., 6 figs., 1 tab

  7. Lessons of nuclear robot history

    International Nuclear Information System (INIS)

    Oomichi, Takeo

    2014-01-01

    Severe accidents occurred at Fukushima Daiichi Nuclear Power Station stirred up people's great expectation of nuclear robot's deployment. However unexpected nuclear disaster, especially rupture of reactor building caused by core meltdown and hydrogen explosion, made it quite difficult to introduce nuclear robot under high radiation environment to cease accidents and dispose damaged reactor. Robotics Society of Japan (RSJ) set up committee to look back upon lessons learned from 50 year's past experience of nuclear robot development and summarized 'Lessons of nuclear robot history', which was shown on the home page website of RSJ. This article outlined it with personal comment. History of nuclear robot developed for inspection and maintenance at normal operation and for specific required response at nuclear accidents was reviewed with many examples at home and abroad for TMI, Chernobyl and JCO accidents. Present state of Fukushima accident response robot's introduction and development was also described with some comments on nuclear robot development from academia based on lessons. (T. Tanaka)

  8. Development of damage functions for high-rise building components

    International Nuclear Information System (INIS)

    Kustu, O.; Miller, D.D.; Brokken, S.T.

    1982-10-01

    The component approach for predicting the effects that ground motion from underground nuclear explosions will have on structures involves predicting the damage to each structural and nonstructural component of a building on the basis of the expected local deformation that most affects the damage to the component. This study was conducted to provide the basic data necessary to evaluate the component approach. Available published laboratory test data for various high-rise building components were collected. These data were analyzed statistically to determine damage threshold values and their variabilities, which in turn were used to derive component damage functions. The portion of construction costs attributable to various building components was determined statistically. This information was needed because component damage functions define damage as a percentage of the replacement values of the component, and, in order to calculate the overall building damage factor, the relative cost of each component must be estimated. The feasibility of the component approach to damage prediction is demonstrated. It is recommended that further experimental research directed towards developing an adequate data base of component damage thresholds for all significant building components should be encouraged. Parallel to this effort, detailed damage data from specific buildings damaged in earthquakes should be collected to verify the theoretical procedure

  9. LSD and Genetic Damage

    Science.gov (United States)

    Dishotsky, Norman I.; And Others

    1971-01-01

    Reviews studies of the effects of lysergic acid diethylamide (LSD) on man and other organisms. Concludes that pure LSD injected in moderate doses does not cause chromosome or detectable genetic damage and is not a teratogen or carcinogen. (JM)

  10. Diabetes and nerve damage

    Science.gov (United States)

    Diabetic neuropathy; Diabetes - neuropathy; Diabetes - peripheral neuropathy ... In people with diabetes, the body's nerves can be damaged by decreased blood flow and a high blood sugar level. This condition is ...

  11. Nuclear and conventional energy transformation

    International Nuclear Information System (INIS)

    Schikarski, W.

    1979-03-01

    Atmospheric pollution from fossil fuel- and nuclear power plants have been compared. SO 2 is the substance chosen from coal- and oil fuel power plants. Measured values for chemical pollution are at levels 10 times, and radioactive pollution near to nuclear power plants, 10.000 times, below that which would cause damage to health. (A.R.H.) [pt

  12. Analysis and research status of severe core damage accidents

    International Nuclear Information System (INIS)

    1984-03-01

    The Severe Core Damage Research and Analysis Task Force was established in Nuclear Safety Research Center, Tokai Research Establishment, JAERI, in May, 1982 to make a quantitative analysis on the issues related with the severe core damage accident and also to survey the present status of the research and provide the required research subjects on the severe core damage accident. This report summarizes the results of the works performed by the Task Force during last one and half years. The main subjects investigated are as follows; (1) Discussion on the purposes and necessities of severe core damage accident research, (2) proposal of phenomenological research subjects required in Japan, (3) analysis of severe core damage accidents and identification of risk dominant accident sequences, (4) investigation of significant physical phenomena in severe core damage accidents, and (5) survey of the research status. (author)

  13. Nuclear Medicine

    Science.gov (United States)

    ... Parents/Teachers Resource Links for Students Glossary Nuclear Medicine What is nuclear medicine? What are radioactive tracers? ... funded researchers advancing nuclear medicine? What is nuclear medicine? Nuclear medicine is a medical specialty that uses ...

  14. Nuclear safety. Seguranca nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Aveline, A [Rio Grande do Sul Univ., Porto Alegre, RS (Brazil). Inst. de Fisica

    1981-01-01

    What is nuclear safety Is there any technical way to reduce risks Is it possible to put them at reasonable levels Are there competitiveness and economic reliability to employ the nuclear energy by means of safety technics Looking for answers to these questions the author describes the sources of potential risks to nuclear reactors and tries to apply the answers to the Brazilian Nuclear Programme. (author).

  15. Integrity Analysis of Damaged Steam Generator Tubes

    International Nuclear Information System (INIS)

    Stanic, D.

    1998-01-01

    Variety of degradation mechanisms affecting steam generator tubes makes steam generators as one of the critical components in the nuclear power plants. Depending of their nature, degradation mechanisms cause different types of damages. It requires performance of extensive integrity analysis in order to access various conditions of crack behavior under operating and accidental conditions. Development and application of advanced eddy current techniques for steam generator examination provide good characterization of found damages. Damage characteristics (shape, orientation and dimensions) may be defined and used for further evaluation of damage influence on tube integrity. In comparison with experimental and analytical methods, numerical methods are also efficient tools for integrity assessment. Application of finite element methods provides relatively simple modeling of different type of damages and simulation of various operating conditions. The stress and strain analysis may be performed for elastic and elasto-plastic state with good ability for visual presentation of results. Furthermore, the fracture mechanics parameters may be calculated. Results obtained by numerical analysis supplemented with experimental results are the base for definition of alternative plugging criteria which may significantly reduce the number of plugged tubes. (author)

  16. Nuclear danger in the modern world

    International Nuclear Information System (INIS)

    Sulejmenov, O.O.

    2000-01-01

    It is noted, that nowadays a nuclear danger proceeds from nuclear depositions of countries having own nuclear weapons. Since Kazakhstan is one of the first country in the world which fulfilled regulations of Lisbon Protocol and liquidated own nuclear potential, author regards that Kazakhstan have moral right for initiating process of attachment to Comprehensive Nuclear Test Ban Treaty by countries having nuclear weapon. Now for Kazakhstan there are urgent problems: financing of post-conversion processes; re-cultivation of territory contaminated by residuals from nuclear weapons test; rehabilitation of population health, damaged from test of mass destruction weapon. Scientists of Kazakhstan estimated damage from nuclear test on Kazakstan territory in 10 billion dollars. It is necessary international efforts of all public organizations of the world for all world sites. One of the financing source could be means from reduction of nuclear arms production

  17. Invisible nuclear; converting nuclear

    International Nuclear Information System (INIS)

    Park, Jongmoon

    1993-03-01

    This book consists of 14 chapters which are CNN era and big science, from East and West to North and South, illusory nuclear strategy, UN and nuclear arms reduction, management of armaments, advent of petroleum period, the track of nuclear power generation, view of energy, internationalization of environment, the war over water in the Middle East, influence of radiation and an isotope technology transfer and transfer armament into civilian industry, the end of nuclear period and the nuclear Nonproliferation, national scientific and technological power and political organ and executive organ.

  18. Draft statement by the Watt Committee on Safety and related topics as respects nuclear power

    Energy Technology Data Exchange (ETDEWEB)

    1982-03-01

    The following topics are examined, with particular reference to nuclear power: the nature of risk; waste disposal to the environment (ecological damage and radiation damage due to nuclear plants and fossil-fuel plants); the benefits of nuclear power (including discussion of the following matters: need to conserve fossil fuels; safety; and possibility of diversion to nuclear weapons).

  19. Safety of nuclear ships

    International Nuclear Information System (INIS)

    1978-01-01

    Interest in the utilization of nuclear steam supply systems for merchant ships and icebreakers has recently increased considerably due to the sharp rise in oil prices and the continuing trend towards larger and faster merchant ships. Canada, for example, is considering construction of an icebreaker in the near future. On the other hand, an accident which could result in serious damage to or the sinking of a nuclear ship is potentially far more dangerous to the general public than a similar accident with a conventional ship. Therefore, it was very important to evaluate in an international forum the safety of nuclear ships in the light of our contemporary safety philosophy, taking into account the results of cumulative operating experience with nuclear ships in operation. The philosophy and safety requirement for land-based nuclear installations were outlined because of many common features for both land-based nuclear installations and nuclear ships. Nevertheless, essential specific safety requirements for nuclear ships must always be considered, and the work on safety problems for nuclear ships sponsored by the NEA was regarded as an important step towards developing an international code of practice by IMCO on the safety of nuclear merchant ships. One session was devoted to the quantitative assessment of nuclear ship safety. The probability technique of an accident risk assessment for nuclear power plants is well known and widely used. Its modification, to make it applicable to nuclear propelled merchant ships, was discussed in some papers. Mathematical models for describing various postulated accidents with nuclear ships were developed and reported by several speakers. Several papers discussed a loss-of-coolant accident (LOCA) with nuclear steam supply systems of nuclear ships and engineering design features to prevent a radioactive effluence after LOCA. Other types of postulated accidents with reactors and systems in static and dynamic conditions were also

  20. Coal transportation road damage

    International Nuclear Information System (INIS)

    Burtraw, D.; Harrison, K.; Pawlowski, J.A.

    1994-01-01

    Heavy trucks are primarily responsible for pavement damage to the nation's highways. In this paper we evaluate the pavement damage caused by coal trucks. We analyze the chief source of pavement damage (vehicle weight per axle, not total vehicle weight) and the chief cost involved (the periodic overlay that is required when a road's surface becomes worn). This analysis is presented in two stages. In the first section we present a synopsis of current economic theory including simple versions of the formulas that can be: used to calculate costs of pavement wear. In the second section we apply this theory to a specific example proximate to the reference environment for the Fuel Cycle Study in New Mexico in order to provide a numerical measure of the magnitude of the costs

  1. Natural resource damage assessment

    International Nuclear Information System (INIS)

    Seddelmeyer, J.

    1991-01-01

    The assessment and collection of natural resource damages from petroleum and chemical companies unfortunate enough to have injured publicly owned natural resources is perhaps the most rapidly expanding area of environmental liability. The idea of recovering for injury to publicly owned natural resources is an extension of traditional common law tort concepts under which a person who negligently injures another or his property is called upon to compensate the injured party. Normally, once liability has been established, it is a fairly straightforward matter to calculate the various elements of loss, such as the cost to repair or replace damaged property, or medical expenses, and lost income. More difficult questions, such as the amount to be awarded for pain and suffering or emotional distress, are left to the jury, although courts limit the circumstances in which the jury is permitted to award such damages

  2. Plight of China nuclear liability law and solutions of nuclear operating companies

    International Nuclear Information System (INIS)

    Su Guangchao; Wang Yonggang; Tang Yangyang

    2010-01-01

    With the development of nuclear use for peaceful purposes and the intensification of international cooperation in the field of nuclear energy, many countries attach more and more importance to legal risks of nuclear liability, and the companies in nuclear industry also enhance research on restrictive articles of nuclear liability in their international businesses. However, because China has neither signed any international convention on civil liability for nuclear damage nor adopted any law on atomic energy and on compensation for nuclear damage, many impediments often occur in international cooperation and trade. This essay is trying to outline the status and structure of international nuclear liability, analyze nuclear liabilities in international procurement for nuclear operating companies and respective solutions. (authors)

  3. Analysis of emergency operating procedures effectiveness for core damage prevention using computer code RELAP for nuclear power plants with VVER-1000/B-320 in reference to primary to secondary circuit leak with external power loss and BRU-A stuck open failure

    International Nuclear Information System (INIS)

    Arkhangelski, L.; Sheveliov, D. V.

    1999-01-01

    This report presents analysis of development emergency operating procedures effectiveness for possible accident on nuclear power plant with WWER-1000 reactor type. Accident initiating event is the primary to secondary circuit leak caused by steam generator primary cover lift-up. In according to conservative assumptions the following additional failures were considered: dump valve BRU-A stuck open failure; loss of external power. The results of this work are represented as a comparative analysis of two possible ways of accident evolution: according to functioning automatic safety systems responses; according to accident management based on development emergency operating procedures with operator intervention. Developed emergency operating procedures assure the following significant goals to mitigate accident sequences: optimal use of ECCS water inventory; severe core damage prevention; mitigation of environment radioactive contamination. (authors)

  4. Damage of fuel assembly premature changing in a power reactor

    International Nuclear Information System (INIS)

    Rudik, A.P.

    1987-01-01

    Material balance, including energy recovery and nuclear fuel flow rate, under conditions of premature FA extraction from power reactor is considered. It is shown that in cases when before and after FA extraction reactor operates not under optimal conditions damage of FA premature changing is proportional to the first degree of fuel incomplete burning. If normal operating conditions of reactor or its operation after FA changing is optimal, the damage is proportional to the square of fuel incomplete burning

  5. PBF severe fuel damage program: results and comparison to analysis

    International Nuclear Information System (INIS)

    McDonald, P.E.; Buescher, B.J.; Gruen, G.E.; Hobbins, R.R.; McCardell, R.K.

    1983-01-01

    The United States Nuclear Regulatory Commission has initiated a severe fuel damage research program in the Power Burst Facility (PBF) to investigate fuel rod and core response, and fission product and hydrogen release and transport under degraded core cooling accident conditions. This paper presents a description of Phase I of the PBF Severe Fuel Damage Program, discusses the results of the first experiment, and compares those results with analysis performed using the TRAC-BD1 computer code

  6. Nuclear for curious

    International Nuclear Information System (INIS)

    Fontesse, Max

    2015-01-01

    The author aims at proposing a popularisation of nuclear science. In a first part which addresses general aspects and uses of radioactivity, he presents and describes the matter structure, proposes a historical overview, introduces the various forms of nuclear activity (α, β, and γ radioactivity) and natural radioactivity. He explains why radiation can be called ionizing radiation (action of ionizing radiations on matter, comparison between α, β, X, and γ radiations). He presents the various radiological units, addresses issues related to radiation protection (main damages on human body, impact of a radiation on the whole body), and describes various uses of radioactivity (nuclear medicine, dating, heritage conservation, and others). In the second part, the author addresses uses of nuclear energy. He describes artificial radioactivity (nuclear fission, criticality), the various types of nuclear reactors (natural uranium graphite gas, heavy water, pressurised water, boiling water, fast breeders), and the nuclear fuel cycle (mining extraction, refinery, isotopic enrichment, assembly fabrication, cooling in pool, reprocessing, nuclear wastes, MOX fuel). The third part addresses perspectives: EPR, future reactors, nuclear fusion

  7. Contribution to the damage measurement of reinforced concrete buildings under seismic solicitations: proposal of an improvement for the evaluation of the damaging potential of a signal and of the damage for the girders structures: introduction to the reliability analysis of the damage in terms of the damaging potential of a seismic signal

    International Nuclear Information System (INIS)

    Naze, P.A.

    2004-12-01

    Building damage measurement during and after an earthquake remains an economical as well as technical stake as difficult to cope with as the problem it raises all the more because its importance depends on the field or the building function: civil, medical, military, nuclear... Even building ruin remains one of the most critical diagnosis to establish. Then since prediction of earthquake still remains impossible, foreseeing structural damages due to seismic motion has become a key point in earthquake engineering. This work aims at evaluating the relevance of classical seismic signal damaging potential indices and at proposing improvement of these indices in order to provide better prediction of structural damage due to earthquake. The first part supplies a non exhaustive state of the art of main Damaging Potential Indices IP and Damage Indices ID used in earthquake engineering. In the second part, IP/ID correlations results are analysed in order to evaluate IP relevance, to justify displacement based approach use (capacity spectrum method) for damage prediction and to make good the proposal for improvement of Damaging Potential Index. But studding seismic signal damaging potential is usually not enough to foresee damage firstly because scalar representation of damaging potential is not easy to link to physics reality and secondly because of damage scattering often observed for a single value of seismic signal damaging potential. In the same way, a single damage index value may correspond to very different structural damage states. Hence, this work carries on with a contribution to damage index reliability improvement, able to detect real structural damage appearance as well as to quantify this damage by associating the distance between one structural sate and the structural collapse, defined as an instability. (author)

  8. Radiation damage effects in solids special topic volume with invited peer reviewed papers only

    CERN Document Server

    Virk, Hardev Singh

    2013-01-01

    Public interest and concern about radiation damage effects has increased during recent times. Nuclear radiation proved to be a precursor for the study of radiation damage effects in solids. In general, all types of radiation, e.g. X-ray, gamma ray, heavy ions, fission fragments and neutrons produce damage effects in materials. Radiation damage latent tracks in solids find applications in nuclear and elementary particle physics, chemistry, radiobiology, earth sciences, nuclear engineering, and a host of other areas such as nuclear safeguards, virus counting, ion track filters, uranium exploration and archaeology. Radiation dosimetry and reactor shielding also involve concepts based on radiation damage in solids. This special volume consists of ten Chapters, including Review and Research Papers on various topics in this field.Physical scientists known to be investigating the effects of radiation on material were invited to contribute research and review papers on the areas of their specialty. The topics include...

  9. Report realized on behalf of the Foreign Affairs Commission, of Defense and Armed Forces on the law project allowing the agreement approbation between the French Republic Government and the Russian Federal Government relative to the civil liability concerning the nuclear damages occurring from goods supplying to nuclear facilities in Russian Federation and becoming from the French Republic

    International Nuclear Information System (INIS)

    2002-01-01

    The first part presents the international civil liability system in the nuclear domain and details then the 20 june 2000 agreement. It presents also the main aspects of the french-russian cooperation in the nuclear domain. (A.L.B.)

  10. Nuclear energy and nuclear law in Macedonia and neighbor countries Bulgaria, Serbia and Albania

    OpenAIRE

    Ampovska, Marija

    2013-01-01

    In this paper the emphasis is on nuclear energy and its peaceful use in the world, in accordance with the construction of nuclear law on international level and in the scope of the national regime. The world today is living in a nuclear renaissance where nuclear energy is used in great quantity and the usage is growing. On the other side, the 1986 Chernobyl accident confirmed prior theoretical assessments that a nuclear accident might cause damage of an extreme magnitude. The detrimental effe...

  11. Comments on establishing a causal link between an ''occurrence or succession of occurrences having the same origin'' and ''damage'', required for implementing the Convention on Third Party Liability in the field on nuclear energy

    International Nuclear Information System (INIS)

    Hebert, J.

    1985-01-01

    This paper considers the problems of proving the causal link between a nuclear incident and bodily injury when the latter is a non-stochastic effect or a stochastic effect of ionizing radiation and the author suggests that a solution should be sought in presumption. In the absence of such a solution, inconsistencies with the present tendency to raise coverage amounts might be misunderstood by public opinion if an incident were to occur. To conclude, the author suggests that proof of the causal link should act as a trigger for transfers of financial charges between the different categories of persons. (NEA) [fr

  12. The compensation of damage in Germany following the Chernobyl accident

    International Nuclear Information System (INIS)

    Eich, W.

    2003-01-01

    In the framework of the workshop on the indemnification of damage in the event of a nuclear accident, this paper presents the proceeding of the the discussion on the compensation of damage in Germany following the Chernobyl accident. This paper presents also the national experiences and opinions, a documentation of the Federal Office of Administration on the topic, the example of Tokai-mura accident third party liability and compensation and the third party liability in the field of nuclear law in Ireland. (A.L.B.)

  13. mapDamage

    DEFF Research Database (Denmark)

    Ginolhac, Aurélien; Rasmussen, Morten; Gilbert, Tom

    2011-01-01

    Ancient DNA extracts consist of a mixture of contaminant DNA molecules, most often originating from environmental microbes, and endogenous fragments exhibiting substantial levels of DNA damage. The latter introduce specific nucleotide misincorporations and DNA fragmentation signatures in sequenci...... of the SAMtools suite and R environment and has been validated on both GNU/Linux and MacOSX operating systems....

  14. Core damage risk indicators

    International Nuclear Information System (INIS)

    Szikszai, T.

    1994-01-01

    The purpose of this document is to show a method for the fast recalculation of the PSA. To avoid the information loose, it is necessary to simplify the PSA models, or at least reorganize them. The method, introduced in this document, require that preparation, so we try to show, how to do that. This document is an introduction. This is the starting point of the work related to the development of the risk indicators. In the future, with the application of this method, we are going to show an everyday use of the PSA results to produce the indicators of the core damage risk. There are two different indicators of the plant safety performance, related to the core damage risk. The first is the core damage frequency indicator (CDFI), and the second is the core damage probability indicator (CDPI). Of course, we cannot describe all of the possible ways to use these indicators, rather we will try to introduce the requirements to establish such an indicator system and the calculation process

  15. Harmonisation of Nuclear Liability Regimes in Europe

    International Nuclear Information System (INIS)

    Sladonja, B.

    2000-01-01

    After we have learned about the current discussions concerning the Paris Convention revision exercise and the open matters relating to the liability limits and insurance for nuclear damages, prescription period, definition of nuclear damage etc. and different approaches in some PCC in adopting their legislation as well as about the adoption of the Protocol to Amend the Vienna Convention and Convention on Supplementary Compensation for Nuclear Damage, within the Vienna Convention countries, during the obtained Session 9 of this Conference we will focus our attention on the matters which has been discovered from the moment when the reports has been written till the date of this Conference

  16. Nuclear fuels

    International Nuclear Information System (INIS)

    2008-01-01

    The nuclear fuel is one of the key component of a nuclear reactor. Inside it, the fission reactions of heavy atoms, uranium and plutonium, take place. It is located in the core of the reactor, but also in the core of the whole nuclear system. Its design and properties influence the behaviour, the efficiency and the safety of the reactor. Even if it represents a weak share of the generated electricity cost, its proper use represents an important economic stake. Important improvements remain to be made to increase its residence time inside the reactor, to supply more energy, and to improve its robustness. Beyond the economical and safety considerations, strategical questions have to find an answer, like the use of plutonium, the management of resources and the management of nuclear wastes and real technological challenges have to be taken up. This monograph summarizes the existing knowledge about the nuclear fuel, its behaviour inside the reactor, its limits of use, and its R and D tracks. It illustrates also the researches in progress and presents some key results obtained recently. Content: 1 - Introduction; 2 - The fuel of water-cooled reactors: aspect, fabrication, behaviour of UO 2 and MOX fuels inside the reactor, behaviour in loss of tightness situation, microscopic morphology of fuel ceramics and evolution under irradiation - migration and localisation of fission products in UOX and MOX matrices, modeling of fuels behaviour - modeling of defects and fission products in the UO 2 ceramics by ab initio calculations, cladding and assembly materials, pellet-cladding interaction, advanced UO 2 and MOX ceramics, mechanical behaviour of the fuel assembly, fuel during a loss of coolant accident, fuel during a reactivity accident, fuel during a serious accident, fuel management inside reactor cores, fuel cycle materials balance, long-term behaviour of the spent fuel, fuel of boiling water reactors; 3 - the fuel of liquid metal fast reactors: fast neutrons radiation

  17. Reassessing the nuclear liability regime

    International Nuclear Information System (INIS)

    Havinh Phuong

    1985-01-01

    The nuclear liability regime was thoroughly reviewed by nuclear plant operators, officials of regulatory authorities, and legal and insurance experts at the Symposium on Nuclear Third Party Liability and Insurance, held in September 1984 in Munich, Federal Republic of Germany. The symposium highlighted specific areas where adjustments or improvements would be needed in order to cope with practical problems encountered or emerging issues. By focusing on questions of legitimate concern to the public, it also sought to promote confidence in a compensation system for public protection that is in many ways unique. Topics addressed included the following: greater harmonization of the compensation amounts for nuclear damage established in different countries and in territorial scope; the concept of unlimited liability; the time limitation for compensation claims; the problem of proving causation; the concept of nuclear damage; and insurance coverage

  18. Nuclear low and environmental protection

    International Nuclear Information System (INIS)

    Vencato, A.C.B.

    1982-01-01

    The imperceptible character of nuclear radiation on the human senses and their harmful effects on living beings and the environment is emphasised. This is based on a review of published works about the concepts of energy and ecology. The potential hazards of a possible nuclear accident and the damage it would cause to a community as well as the problem of radioactive waste disposal are raised. The conclusions and recommendations of the Brazilian Physics Society's Report on Nuclear Pollution are endorsed. The general guidelines of Brazilian Legislation are presented. The legal aspects of nuclear reactor licensing in West Germany, the United Kingdom, France and Brazil are shown from the point of view of the applicable legal system, the licensing bodies, the general frame and scope, public participation, technical safety bodies, as well as the inspection procedures. The concepts of absolute and objective civil responsibility for nuclear damage are reviewed. The judicial principle of equity is considered in view of the exceptional character of the nuclear risk. The main aspects of the international Conventions of Paris, Brussels and Viena on civil ability of nuclear damage are presented. Some philosphical and judicial questions are discussed emphasising the instrumentality of the law control and effective protection. The final suggestion is the exchange of ideas with a view to obtain the maximum safety in the operation of nuclear installations. (author) [pt

  19. Nuclear hazard/fire hazard: an elusive and important linkage

    International Nuclear Information System (INIS)

    Mariani, L.P.

    1977-01-01

    The Brown's Ferry Fire signaled a yellow alert for nuclear safety related fire protection and showed that fire protection engineering must be regarded as a bona fide nuclear discipline. A single-failure design criteria violation resulted in fire damage to plant systems and plant instrumentation. Localized damage lead to significant consequences. Although the linkage between fire and nuclear hazard is termed subtle, effective standards and criteria development must be aimed to future plants. Combined fire protection and nuclear engineering inspections are planned

  20. Parvoviral nuclear import: bypassing the host nuclear-transport machinery.

    Science.gov (United States)

    Cohen, Sarah; Behzad, Ali R; Carroll, Jeffrey B; Panté, Nelly

    2006-11-01

    The parvovirus Minute virus of mice (MVM) is a small DNA virus that replicates in the nucleus of its host cells. However, very little is known about the mechanisms underlying parvovirus' nuclear import. Recently, it was found that microinjection of MVM into the cytoplasm of Xenopus oocytes causes damage to the nuclear envelope (NE), suggesting that the nuclear-import mechanism of MVM involves disruption of the NE and import through the resulting breaks. Here, fluorescence microscopy and electron microscopy were used to examine the effect of MVM on host-cell nuclear structure during infection of mouse fibroblast cells. It was found that MVM caused dramatic changes in nuclear shape and morphology, alterations of nuclear lamin immunostaining and breaks in the NE of infected cells. Thus, it seems that the unusual nuclear-import mechanism observed in Xenopus oocytes is in fact used by MVM during infection of host cells.

  1. Numerical study of damage in unsaturated Geological and Engineered barriers

    International Nuclear Information System (INIS)

    Arson, C.; Gatmiri, B.

    2011-01-01

    The theoretical framework of a damage model dedicated to non-isothermal unsaturated porous media is presented. The damage variable is a second-order tensor, and the model is formulated in independent state variables. The behavior laws are derived from a postulated expression of Helmholtz free energy. The damaged rigidities are computed by applying the Principle of Equivalent Elastic Energy (PEEE). Internal length parameters are introduced in the expressions of liquid water and vapor conductivities, to account for cracking effects on fluid flows. The damage model has been implemented in Θ-Stock Finite Element program. The mechanical aspect of the damage model is validated by simulating a triaxial compression test on a dry isothermal brittle material. Then, a sophisticated model of nuclear waste disposal, involving two non-isothermal unsaturated porous media, is reproduced. The results obtained in elasticity are in good agreement with the results presented in the corresponding reference article. A parametric study on initial damage is then performed to assess the influence of the Excavated Damaged Zone (EDZ) on the response of the nuclear waste repository during the heating phase. The trends meet the theoretical expectations. (authors)

  2. [Nuclear theory

    International Nuclear Information System (INIS)

    Haxton, W.

    1990-01-01

    This report discusses research in nuclear physics. Topics covered in this paper are: symmetry principles; nuclear astrophysics; nuclear structure; quark-gluon plasma; quantum chromodynamics; symmetry breaking; nuclear deformation; and cold fusion

  3. Abstracts of 3. congress of global anti-nuclear alliance

    International Nuclear Information System (INIS)

    2000-01-01

    The 3 congress of global anti-nuclear alliance was held on 18-20 May, 2000 in Astana. There were 55 reports on different aspects of nuclear disarmament; nuclear safeguards; safe operation of nuclear power plants; rehabilitation of population and lands, damaged from many-years tests in Semipalatinsk site; radiobiological monitoring of ecosystems and others presented at the congress

  4. Nuclear radiation and the properties of concrete

    International Nuclear Information System (INIS)

    Kaplan, M.F.

    1983-08-01

    Concrete is used for structures in which the concrete is exposed to nuclear radiation. Exposure to nuclear radiation may affect the properties of concrete. The report mentions the types of nuclear radiation while radiation damage in concrete is discussed. Attention is also given to the effects of neutron and gamma radiation on compressive and tensile strength of concrete. Finally radiation shielding, the attenuation of nuclear radiation and the value of concrete as a shielding material is discussed

  5. Brazilian nuclear legislation. Revision n.1/2002; Legislacao nuclear brasileira. Revisao n. 1/2002

    Energy Technology Data Exchange (ETDEWEB)

    Matos, Gilberto Cardoso de

    2002-07-01

    This work intends to facilitate the access to the Brazilian nuclear legislation and other legal instruments, foreseeing the use of nuclear energy and ionizing radiation in health, work and environment areas up to 2002. Legislation on the civil liability of nuclear damage, the law of licensing taxes, controlling and inspection are also included.

  6. Nuclear insurance problems in Spain

    International Nuclear Information System (INIS)

    Gomez del Campo, Julian.

    1977-01-01

    The purpose of this paper is to study the problems raised in Spain by third party liability insurance for nuclear damage. National law in this field is based on the Paris Convention on nuclear third party liability and defines the conditions of liability of operators of nuclear installations. The insurance contract requirements must comply with the regulations on cover for nuclear risks, under the control of the Finance Ministry's competent services. Certain exceptional nuclear risks which cannot be covered entirely by ordinary insurance policies, are taken over by the Consorcio de Compensacion de Seguros which belongs to this Ministry. From the insurance viewpoint, the regulations make a distinction between nuclear and radioactive installations and nuclear transport. (NEA) [fr

  7. Nuclear topics

    International Nuclear Information System (INIS)

    Lukner, C.

    1982-07-01

    The pamphlet touches on all aspects of nuclear energy, from the world energy demands and consumption, the energy program of the Federal Government, nuclear power plants in the world, nuclear fusion, nuclear liability up to the nuclear fuel cycle and the shutdown of nuclear power plants. (HSCH) [de

  8. Immunoassay of DNA damage

    International Nuclear Information System (INIS)

    Gasparro, F.P.; Santella, R.M.

    1988-01-01

    The direct photomodification of DNA by ultraviolet light or the photo-induced addition of exogenous compounds to DNA components results in alterations of DNA structure ranging from subtle to profound. There are two consequences of these conformational changes. First, cells in which the DNA has been damaged are capable of executing repair steps. Second, the DNA which is usually of very low immunogenicity now becomes highly antigenic. This latter property has allowed the production of a series of monoclonal antibodies that recognize photo-induced DNA damage. Monoclonal antibodies have been generated that recognize the 4',5'-monoadduct and the crosslink of 8-methoxypsoralen in DNA. In addition, another antibody has been prepared which recognizes the furan-side monoadduct of 6,4,4'-trimethylangelicin in DNA. These monoclonal antibodies have been characterized as to sensitivity and specificity using non-competitive and competitive enzyme-linked-immunosorbent assays (ELISA). (author)

  9. Neutron induced radiation damage

    International Nuclear Information System (INIS)

    Williams, M.M.R.

    1977-01-01

    We derive a general expression for the number of displaced atoms of type j caused by a primary knock-on of type i. The Kinchin-Pease model is used, but considerably generalised to allow for realistic atomic potentials. Two cases are considered in detail: the single particle problem causing a cascade and the neutron initiated problem which leads to multiple subcascades. Numerical results have been obtained for a variety of scattering laws. An important conclusion is that neutron initiated damage is much more severe than atom-initiated damage and leads to the number of displaced atoms being a factor of (A+1) 2 /4A larger than the single primary knock-on theory predicts. A is the ratio of the atomic mass to the neutron mass. The importance of this result to the theory of neutron sputtering is explained. (orig.) [de

  10. Immunoassay of DNA damage

    Energy Technology Data Exchange (ETDEWEB)

    Gasparro, F P; Santella, R M

    1988-09-01

    The direct photomodification of DNA by ultraviolet light or the photo-induced addition of exogenous compounds to DNA components results in alterations of DNA structure ranging from subtle to profound. There are two consequences of these conformational changes. First, cells in which the DNA has been damaged are capable of executing repair steps. Second, the DNA which is usually of very low immunogenicity now becomes highly antigenic. This latter property has allowed the production of a series of monoclonal antibodies that recognize photo-induced DNA damage. Monoclonal antibodies have been generated that recognize the 4',5'-monoadduct and the crosslink of 8-methoxypsoralen in DNA. In addition, another antibody has been prepared which recognizes the furan-side monoadduct of 6,4,4'-trimethylangelicin in DNA. These monoclonal antibodies have been characterized as to sensitivity and specificity using non-competitive and competitive enzyme-linked-immunosorbent assays (ELISA).

  11. Radiation damage in DNA

    International Nuclear Information System (INIS)

    Lafleur, V.

    1978-01-01

    A number of experiments are described with the purpose to obtain a better insight in the chemical nature and the biological significance of radiation-induced damage in DNA, with some emphasis on the significance of alkali-labile sites. It is shown that not only reactions of OH radicals but also of H radicals introduce breaks and other inactivating damage in single-standed phiX174 DNA. It is found that phosphate buffer is very suitable for the study of the reactions of H radicals with DNA, as the H 2 PO 4 - ions convert the hydrated electrons into H radicals. The hydrated electron, which does react with DNA, does not cause a detectable inactivation. (Auth.)

  12. Radiation damage of uranium

    International Nuclear Information System (INIS)

    Lazarevic, Dj.

    1966-11-01

    Study of radiation damage covered the following: Kinetics of electric resistance of uranium and uranium alloy with 1% of molybdenum dependent on the second phase and burnup rate; Study of gas precipitation and diffusion of bubbles by transmission electron microscopy; Numerical analysis of the influence of defects distribution and concentration on the rare gas precipitation in uranium; study of thermal sedimentation of uranium alloy with molybdenum; diffusion of rare gas in metal by gas chromatography method

  13. Cavitation damage of ceramics

    International Nuclear Information System (INIS)

    Kovalenko, V.I.; Marinin, V.G.

    1988-01-01

    Consideration is given to results of investigation of ceramic material damage under the effect of cavitation field on their surface, formed in water under the face of exponential concentrator, connected with ultrasonic generator UZY-3-0.4. Amplitude of vibrations of concentrator face (30+-2)x10 -6 m, frequency-21 kHz. It was established that ceramics resistance to cavitation effect correlated with the product of critical of stress intensity factor and material hardness

  14. Nondestructive damage detection and evaluation technique for seismically damaged structures

    Science.gov (United States)

    Adachi, Yukio; Unjoh, Shigeki; Kondoh, Masuo; Ohsumi, Michio

    1999-02-01

    The development of quantitative damage detection and evaluation technique, and damage detection technique for invisible damages of structures are required according to the lessons from the 1995 Hyogo-ken Nanbu earthquake. In this study, two quantitative damage sensing techniques for highway bridge structures are proposed. One method is to measure the change of vibration characteristics of the bridge structure. According to the damage detection test for damaged bridge column by shaking table test, this method can successfully detect the vibration characteristic change caused by damage progress due to increment excitations. The other method is to use self-diagnosis intelligent materials. According to the reinforced concrete beam specimen test, the second method can detect the damage by rupture of intelligent sensors, such as optical fiber or carbon fiber reinforced plastic rod.

  15. Nuclear power and nuclear weapons

    International Nuclear Information System (INIS)

    Vaughen, V.C.A.

    1983-01-01

    The proliferation of nuclear weapons and the expanded use of nuclear energy for the production of electricity and other peaceful uses are compared. The difference in technologies associated with nuclear weapons and nuclear power plants are described

  16. Pulsed nuclear power plant

    International Nuclear Information System (INIS)

    David, C.V.

    1986-01-01

    This patent describes a nuclear power plant. This power plant consists of: 1.) a cavity; 2.) a detonatable nuclear device in a central region of the cavity; 3.) a working fluid inside of the cavity; 4.) a method to denote a nuclear device inside of the cavity; 5.) a mechanical projection from an interior wall of the cavity for recoiling to absorb a shock wave produced by the detonation of the nuclear device and thereby protecting the cavity from damage. A plurality of segments defines a shell within the cavity and a plurality of shock absorbers, each connecting a corresponding segment to a corresponding location on the wall of the cavity. Each of these shock absorbers regulate the recoil action of the segments; and 6.) means for permitting controlled extraction of a quantity of hot gases from the cavity produced by the vaporization of the working fluid upon detonation of the nuclear device. A method of generating power is also described. This method consists of: 1.) introducing a quantity of water in an underground cavity; 2.) heating the water in the cavity to form saturated steam; 3.) detonating a nuclear device at a central location inside the cavity; 4.) recoiling plate-like elements inside the cavity away from the central location in a mechanically regulated and controlled manner to absorb a shock wave produced by the nuclear device detonation and thereby protect the underground cavity against damage; 5.) extracting a quantity of superheated steam produced by the detonation of the nuclear device; and 6.) Converting the energy in the extracted superheated steam into electrical power

  17. Nuclear Safety Review 2013

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-07-15

    The Nuclear Safety Review 2013 focuses on the dominant nuclear safety trends, issues and challenges in 2012. The Executive Overview provides crosscutting and worldwide nuclear safety information along with a summary of the major sections covered in this report. Sections A-E of this report cover improving radiation, transport and waste safety; strengthening safety in nuclear installations; improving regulatory infrastructure and effectiveness; enhancing emergency preparedness and response (EPR); and civil liability for nuclear damage. The Appendix provides details on the activities of the Commission on Safety Standards (CSS), and activities relevant to the IAEA Safety Standards. The world nuclear community has made noteworthy progress in strengthening nuclear safety in 2012, as promoted by the IAEA Action Plan on Nuclear Safety (hereinafter referred to as ''the Action Plan''). For example, an overwhelming majority of Member States with operating nuclear power plants (NPPs) have undertaken and essentially completed comprehensive safety reassessments ('stress tests') with the aim of evaluating the design and safety aspects of plant robustness to protect against extreme events, including: defence in depth, safety margins, cliff edge effects, multiple failures, and the prolonged loss of support systems. As a result, many have introduced additional safety measures including mitigation of station blackout. Moreover, the IAEA's peer review services and safety standards have been reviewed and strengthened where needed. Capacity building programmes have been built or improved, and EPR programmes have also been reviewed and improved. Furthermore, in 2012, the IAEA continued to share lessons learned from the Fukushima Daiichi accident with the nuclear community including through three international experts' meetings (IEMs) on reactor and spent fuel safety, communication in the event of a nuclear or radiological emergency, and protection against extreme earthquakes and tsunamis.

  18. Nuclear Safety Review 2013

    International Nuclear Information System (INIS)

    2013-07-01

    The Nuclear Safety Review 2013 focuses on the dominant nuclear safety trends, issues and challenges in 2012. The Executive Overview provides crosscutting and worldwide nuclear safety information along with a summary of the major sections covered in this report. Sections A-E of this report cover improving radiation, transport and waste safety; strengthening safety in nuclear installations; improving regulatory infrastructure and effectiveness; enhancing emergency preparedness and response (EPR); and civil liability for nuclear damage. The Appendix provides details on the activities of the Commission on Safety Standards (CSS), and activities relevant to the IAEA Safety Standards. The world nuclear community has made noteworthy progress in strengthening nuclear safety in 2012, as promoted by the IAEA Action Plan on Nuclear Safety (hereinafter referred to as ''the Action Plan''). For example, an overwhelming majority of Member States with operating nuclear power plants (NPPs) have undertaken and essentially completed comprehensive safety reassessments ('stress tests') with the aim of evaluating the design and safety aspects of plant robustness to protect against extreme events, including: defence in depth, safety margins, cliff edge effects, multiple failures, and the prolonged loss of support systems. As a result, many have introduced additional safety measures including mitigation of station blackout. Moreover, the IAEA's peer review services and safety standards have been reviewed and strengthened where needed. Capacity building programmes have been built or improved, and EPR programmes have also been reviewed and improved. Furthermore, in 2012, the IAEA continued to share lessons learned from the Fukushima Daiichi accident with the nuclear community including through three international experts' meetings (IEMs) on reactor and spent fuel safety, communication in the event of a nuclear or radiological emergency, and protection against extreme earthquakes and tsunamis

  19. Compilation of radiation damage test data. I

    International Nuclear Information System (INIS)

    Schoenbacher, H.; Stolarz-Izycka, A.

    1979-01-01

    This report summarizes radiation damage test data on commercially available organic cable insulation and jacket materials: ethylene-propylene rubber, Hypalon, neoprene rubber, polyethylene, polyurethane, polyvinylchloride, silicone rubber, etc. The materials have been irradiated in a nuclear reactor to integrated absorbed doses from 5 X 10 5 to 5 X 10 6 Gy. Mechanical properties, e.g. tensile strength, elongation at break, and hardness, have been tested on irradiated and non-irradiated samples. The results are presented in the form of tables and graphs, to show the effect of the absorbed dose on the measured properties. (Auth.)

  20. Monitoring ageing of components in nuclear plants

    International Nuclear Information System (INIS)

    Fritz, M.R.

    1992-01-01

    There are several mechanisms of ageing or damage in nuclear components, of which the best known can be classified into three categories: generalized damage mechanisms (wear, corrosion, erosion,...), local damage phenomena (fatigue, corrosion,...) and material property degradations. For ageing evaluation, the first requirement is a good understanding of the damage mechanisms and the determination of the kinetic laws and major influencing factors. When these factors are measurable physical parameters, ageing monitoring and periodic evaluation of damage level become possible. From the set of tools available for ageing evaluation, four are presented here in more detail: the transient logging procedure, the defect injuriousness analysis, the fatigue meter, the probabilistic approach to structural integrity. (author)

  1. Monitoring ageing of components in nuclear plants

    Energy Technology Data Exchange (ETDEWEB)

    Fritz, M R [FRAMATOME, Paris (France)

    1992-07-01

    There are several mechanisms of ageing or damage in nuclear components, of which the best known can be classified into three categories: generalized damage mechanisms (wear, corrosion, erosion,...), local damage phenomena (fatigue, corrosion,...) and material property degradations. For ageing evaluation, the first requirement is a good understanding of the damage mechanisms and the determination of the kinetic laws and major influencing factors. When these factors are measurable physical parameters, ageing monitoring and periodic evaluation of damage level become possible. From the set of tools available for ageing evaluation, four are presented here in more detail: the transient logging procedure, the defect injuriousness analysis, the fatigue meter, the probabilistic approach to structural integrity. (author)

  2. Nuclear fundamentals remain

    Directory of Open Access Journals (Sweden)

    Stošić Zoran V.

    2012-01-01

    Full Text Available For Japan, the situation has become extremely difficult since counter-measures to deal with the nuclear accident had to be carried out along with dealing with the broader disaster caused by earthquake and the tsunami. In terms of damage, the Tohoku earthquake and the tsunami have caused the most fatalities and the largest economic loss ever from an earthquake and/or tsunami. The impact of this natural disaster is present not only in Japan but world-wide. The state of affairs in the global energy sector is affected by the consequences which may be lasting for decades. These effects are subject of this article dealing not with the nuclear accident at Fukushima Daiichi NPPs itself, but rather with the world-wide consequences and after effect on nuclear energy development. This includes: environmental damages, socio-economic effects, actions of safety authorities, extended protective measures against external events, the impact on global nuclear energy, triggered nuclear phase-outs and changes in new build plans as well as the sustainability of energy mix itself and an outlook.

  3. The fatigue in the nuclear boilers

    International Nuclear Information System (INIS)

    Hutin, J.P.

    2001-01-01

    This paper presents the main conclusions concerning the presentations of the 23 november 2000 conference on fatigue damage of nuclear facilities. The author presents also some propositions of research and development programs. (A.L.B.)

  4. Conditioning of nuclear reactor fuel

    International Nuclear Information System (INIS)

    1975-01-01

    A method of conditioning the fuel of a nuclear reactor core to minimize failure of the fuel cladding comprising increasing the fuel rod power to a desired maximum power level at a rate below a critical rate which would cause cladding damage is given. Such conditioning allows subsequent freedom of power changes below and up to said maximum power level with minimized danger of cladding damage. (Auth.)

  5. Nuclear EMP induced chaos

    Energy Technology Data Exchange (ETDEWEB)

    Dance, B

    1983-08-01

    In the event of nuclear war, the availability of first class communications facilities and of reliable electricity supplies would be of absolutely vital importance to any of the population surviving the first onslaught not only for their own welfare, but also for the preservation of their nation's retaliation deterrent capability. However, it is to be expected that a single nuclear explosion of adequate size on the outside of the atmosphere would generate a pulse of sufficient intensity to damage communications equipment (including telephones, radio transmitters and receivers) and to interrupt main supplies. The situation caused by electromagnetic pulses (EMP) is discussed.

  6. The nuclear controversy international

    International Nuclear Information System (INIS)

    Doederlein, J.M.

    1975-01-01

    The present paper deals with the following questions: How quickly can the developed nations get as much energy as possible from the nuclear power plants they are building. How can we get a maximum output from a maximum number of nuclear plants to reduce the health and the environment damage that we get from fossil fired power plants. How can we reduce the strain on future generations because of the atmospheric pollution and reduce the strain on future generations because we use up all the oil and the gas that we should leave to them for worthier purposes than energy production. (orig.) [de

  7. Military Robotics and Collateral Damage

    National Research Council Canada - National Science Library

    Kott, Robert Douglass ;Alexander

    2004-01-01

    .... Such concepts raise important questions in terms of their impact on collateral damage. In a broader context, western warfare in general places a continuously growing emphasis on issues of collateral damage...

  8. Nuclear rights - nuclear wrongs

    Energy Technology Data Exchange (ETDEWEB)

    Paul, E.F.; Miller, F.D.; Paul, J.; Ahrens, J.

    1986-01-01

    This book contains 11 selections. The titles are: Three Ways to Kill Innocent Bystanders: Some Conundrums Concerning the Morality of War; The International Defense of Liberty; Two Concepts of Deterrence; Nuclear Deterrence and Arms Control; Ethical Issues for the 1980s; The Moral Status of Nuclear Deterrent Threats; Optimal Deterrence; Morality and Paradoxical Deterrence; Immoral Risks: A Deontological Critique of Nuclear Deterrence; No War Without Dictatorship, No Peace Without Democracy: Foreign Policy as Domestic Politics; Marxism-Leninism and its Strategic Implications for the United States; Tocqueveille War.

  9. Nuclear moments

    CERN Document Server

    Kopferman, H; Massey, H S W

    1958-01-01

    Nuclear Moments focuses on the processes, methodologies, reactions, and transformations of molecules and atoms, including magnetic resonance and nuclear moments. The book first offers information on nuclear moments in free atoms and molecules, including theoretical foundations of hyperfine structure, isotope shift, spectra of diatomic molecules, and vector model of molecules. The manuscript then takes a look at nuclear moments in liquids and crystals. Discussions focus on nuclear paramagnetic and magnetic resonance and nuclear quadrupole resonance. The text discusses nuclear moments and nucl

  10. Radiation damage in semiconductor detectors

    International Nuclear Information System (INIS)

    Kraner, H.W.

    1981-12-01

    A survey is presented of the important damage-producing interactions in semiconductor detectors and estimates of defect numbers are made for MeV protons, neutrons and electrons. Damage effects of fast neutrons in germanium gamma ray spectrometers are given in some detail. General effects in silicon detectors are discussed and damage constants and their relationship to leakage current is introduced

  11. Compensation for the damage caused by the Chernobyl disaster

    International Nuclear Information System (INIS)

    Joirysch, A.; Supataeva, O.

    1993-01-01

    The teachings of the accident at the nuclear power plant of Chernobyl clearly showed that the existing rules of Russian legislation cannot handle the problems in respect of civil liability for nuclear damage. This paper describes how the Soviet State and Soviet law tried to cope with the question of compensation for damage to human health and property in a special legal situation, due to the lack of any particular legislation covering this area and to the fact that the USSR is a Party neither to the Vienna nor the Paris Convention. In 1991 a law of the Russian Federation 'On the social protection of citizens who suffered as a consequence of the Chernobyl disaster' established a State system of services and compensation for such damage and the procedure for financing was laid down by a ministerial letter. 4 refs

  12. Power Burst Facility severe-fuel-damage test program

    International Nuclear Information System (INIS)

    McCardell, R.K.; MacDonald, P.E.

    1982-01-01

    As a result of the Three Mile Island Unit 2 (TMI-2) accident, the United States Nuclear Regulatory Commission (USNRC) has initiated a severe fuel damage research program to investigate fuel rod and core response, and fission product and hydrogen release and transport during degraded core cooling accidents. This paper presents a discussion of the expected benefits of the PBF severe fuel damage tests to the nuclear industry, a description of the first five planned experiments, the results of pretest analysis performed to predict the fuel bundle heatup for the first two experiments, and a discussion of Phase II severe fuel damage experiments. Modifications to the fission product detection system envisioned for the later experiments are also described

  13. Tokamak ARC damage

    International Nuclear Information System (INIS)

    Murray, J.G.; Gorker, G.E.

    1985-01-01

    Tokamak fusion reactors will have large plasma currents of approximately 10 MA with hundreds of megajoules stored in the magnetic fields. When a major plasma instability occurs, the disruption of the plasma current induces voltage in the adjacent conducting structures, giving rise to large transient currents. The induced voltages may be sufficiently high to cause arcing across sector gaps or from one protruding component to another. This report reviews a tokamak arcing scenario and provides guidelines for designing tokamaks to minimize the possibility of arc damage

  14. Fatigue Damage in Wood

    DEFF Research Database (Denmark)

    Clorius, Christian Odin; Pedersen, Martin Bo Uhre; Hoffmeyer, Preben

    1996-01-01

    An investigation of fatigue failure in wood subjected to load cycles in compression parallel to grain is presented. Fatigue failure is found to depend both on the total time under load and on the number of cycles.Recent accelerated fatigue research on wood is reviewed, and a discrepancy between...... to 10 Hz are used. The number of cycles to failure is found to be a poor measure of the fatigue performance of wood. Creep, maximum strain, stiffness and work are monitored throughout the fatigue tests. Accumulated creep is suggested identified with damage and a correlation between stiffness reduction...

  15. Contextualizing aquired brain damage

    DEFF Research Database (Denmark)

    Nielsen, Charlotte Marie Bisgaard

    2014-01-01

    Contextualizing aquired brain damage Traditional approaches study ’communicational problems’ often in a discourse of disabledness or deficitness. With an ontology of communcation as something unique and a presupposed uniqueness of each one of us, how could an integrational approach (Integrational...... for people with aquired brain injuries will be presented and comparatively discussed in a traditional versus an integrational perspective. Preliminary results and considerations on ”methods” and ”participation” from this study will be presented along with an overview of the project's empirical data....

  16. Severe fuel damage projects

    International Nuclear Information System (INIS)

    Sdouz, G.

    1987-10-01

    After the descriptions of the generation of a Severe Fuel Damage Accident in a LWR the hypothetical course of such an accident is explained. Then the most significant projects are described. At each project the experimental facility, the most important results and the concluding models and codes are discussed. The selection of the projects is concentrated on the German Projekt Nukleare Sicherheit (PNS), tests performed at the Idaho National Engineering Laboratory (INEL) and smaller projects in France and Great Britain. 25 refs., 26 figs. (Author)

  17. Tokamak ARC damage

    Energy Technology Data Exchange (ETDEWEB)

    Murray, J.G.; Gorker, G.E.

    1985-01-01

    Tokamak fusion reactors will have large plasma currents of approximately 10 MA with hundreds of megajoules stored in the magnetic fields. When a major plasma instability occurs, the disruption of the plasma current induces voltage in the adjacent conducting structures, giving rise to large transient currents. The induced voltages may be sufficiently high to cause arcing across sector gaps or from one protruding component to another. This report reviews a tokamak arcing scenario and provides guidelines for designing tokamaks to minimize the possibility of arc damage.

  18. Neutron radiation damage studies in the structural materials of a 500 ...

    Indian Academy of Sciences (India)

    UTTIYOARNAB SAHA

    2018-02-23

    Feb 23, 2018 ... data library evaluated by the USA, ENDF/B-VII.1, wherein revisions were taken place in the new evaluations of basic nuclear data .... energy available for damage production after correct- ...... is a normalization factor such that.

  19. Corrosion problems in nuclear power industry

    International Nuclear Information System (INIS)

    Flis, J.; Janik-Czachor, M.

    1980-01-01

    Characteristics were given of steels and alloys used in the PWR nuclear power plants and of water used in the primary and secondary systems. Corrosion damages of materials and installations were described. It was indicated that the damages were due mainly to stress corrosion cracking. Main preventive methods were listed. (author)

  20. Thoracic damage control surgery.

    Science.gov (United States)

    Gonçalves, Roberto; Saad, Roberto

    2016-01-01

    The damage control surgery came up with the philosophy of applying essential maneuvers to control bleeding and abdominal contamination in trauma patients who are within the limits of their physiological reserves. This concept was extended to thoracic injuries, where relatively simple maneuvers can shorten operative time of in extremis patients. This article aims to revise the various damage control techniques in thoracic organs that must be known to the surgeon engaged in emergency care. RESUMO A cirurgia de controle de danos surgiu com a filosofia de se aplicar manobras essenciais para controle de sangramento e contaminação abdominal, em doentes traumatizados, nos limites de suas reservas fisiológicas. Este conceito se estendeu para as lesões torácicas, onde manobras relativamente simples, podem abreviar o tempo operatório de doentes in extremis. Este artigo tem como objetivo, revisar as diversas técnicas de controle de dano em órgãos torácicos, que devem ser de conhecimento do cirurgião que atua na emergência.