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Sample records for nt-probnp predice mal

  1. Impredicative concurrent abstract predicates

    DEFF Research Database (Denmark)

    Svendsen, Kasper; Birkedal, Lars

    2014-01-01

    We present impredicative concurrent abstract predicates { iCAP { a program logic for modular reasoning about concurrent, higher- order, reentrant, imperative code. Building on earlier work, iCAP uses protocols to reason about shared mutable state. A key novel feature of iCAP is the ability to dene...

  2. Axiomatizing GSOS with Predicates

    Directory of Open Access Journals (Sweden)

    Luca Aceto

    2011-08-01

    Full Text Available In this paper, we introduce an extension of the GSOS rule format with predicates such as termination, convergence and divergence. For this format we generalize the technique proposed by Aceto, Bloom and Vaandrager for the automatic generation of ground-complete axiomatizations of bisimilarity over GSOS systems. Our procedure is implemented in a tool that receives SOS specifications as input and derives the corresponding axiomatizations automatically. This paves the way to checking strong bisimilarity over process terms by means of theorem-proving techniques.

  3. Dative experiencer predicates in Hungarian

    NARCIS (Netherlands)

    Rákosi, G.

    2006-01-01

    Dative experiencer predicates in Hungarian investigates the argument structure and the syntax of appeal to- and important-type predicates in Hungarian. Couched in terms of Reinhart’s (2000, 2002) Theta System, the thesis presents arguments for the need to resort to the lexicon in setting up

  4. Toward predicate approaches to modality

    CERN Document Server

    Stern, Johannes

    2016-01-01

    In this volume, the author investigates and argues for, a particular answer to the question: What is the right way to logically analyze modalities from natural language within formal languages? The answer is: by formalizing modal expressions in terms of predicates. But, as in the case of truth, the most intuitive modal principles lead to paradox once the modal notions are conceived as predicates. The book discusses the philosophical interpretation of these modal paradoxes and argues that any satisfactory approach to modality will have to face the paradoxes independently of the grammatical category of the modal notion. By systematizing modal principles with respect to their joint consistency and inconsistency, Stern provides an overview of the options and limitations of the predicate approach to modality that may serve as a useful starting point for future work on predicate approaches to modality. Stern also develops a general strategy for constructing philosophically attractive theories of modal notions conce...

  5. THE NOMINAL PREDICATE (ALBANIAN - ENGLISH)

    OpenAIRE

    Shkelqim Millaku

    2017-01-01

    The aim of this paper is to description the nominal of predicate between two languages (Albanian – English). The purpose of the following discussing is to show that some noun phrases, namely predicate nominal’s, do not seem to exhibit. What is considering the typical behavior of noun phrase? First, they do not seem to be assigned case. Second, they may not assign are roles in normal sense so that they are probably as Theta-marker arguments, unlike referential Noun Phrases.[1] In Albanian lang...

  6. Restricted Predicates for Hypothetical Datalog

    Directory of Open Access Journals (Sweden)

    Fernando Sáenz-Pérez

    2015-12-01

    Full Text Available Hypothetical Datalog is based on an intuitionistic semantics rather than on a classical logic semantics, and embedded implications are allowed in rule bodies. While the usual implication (i.e., the neck of a Horn clause stands for inferring facts, an embedded implication plays the role of assuming its premise for deriving its consequence. A former work introduced both a formal framework and a goal-oriented tabled implementation, allowing negation in rule bodies. While in that work positive assumptions for both facts and rules can occur in the premise, negative assumptions are not allowed. In this work, we cover this subject by introducing a new concept: a restricted predicate, which allows negative assumptions by pruning the usual semantics of a predicate. This new setting has been implemented in the deductive system DES.

  7. Observation Predicates in Flow Logic

    DEFF Research Database (Denmark)

    Nielson, Flemming; Nielson, Hanne Riis; Sun, Hongyan

    2003-01-01

    in such a way that the hard constraints are satisfi ed exactly when the observation predicates report no violations. The development is carried out in a large fragment of a first order logic with negation and also takes care of the transformations necessary in order to adhere to the stratification restrictions...... inherent in Alternation-free Least Fixed Point Logic and similar formalisms such as Datalog....

  8. Grand Mal Seizure

    Science.gov (United States)

    ... grand mal seizures include: A family history of seizure disorders Any injury to the brain from trauma, a ... the risk of birth defects. If you have epilepsy and plan to become pregnant, work with your ...

  9. Gupta, Dr Chhitar Mal

    Indian Academy of Sciences (India)

    Gupta, Dr Chhitar Mal Ph.D. (Agra), FNA, FNASc, FAMS, FTWAS Council Service: 1998-2000. Date of birth: 1 September 1944. Specialization: Membrane Biology, Bio-organic Chemistry and Molecular Biophysics Address: Distinguished Professor and Infosys Chair, Institute of Bioinformatics & Applied Biotechnology, Room ...

  10. Mal de terre

    CERN Document Server

    Reeves, Hubert

    2003-01-01

    Notre planète va mal: réchauffement climatique, épuisement des ressources naturelles, pollutions des sols et de l'eau provoquées par les industries civiles et guerrières, disparité des richesses, malnutrition des hommes, taux d'extinction effarant des espèces vivantes, etc.

  11. The Grammar of Mental Predicates in Japanese.

    Science.gov (United States)

    Onishi, Masayuki

    1997-01-01

    Examines Japanese equivalents of the six mental predicates defined as semantic universals in Natural Semantic Metalanguage theory, with special attention to syntax and semantics of complementation types. It is shown that each primitive predicate has a specific set of syntactic frames for expressing primitive meaning and that extended meanings that…

  12. An Approach to the Nominal Predicates in English and Romanian

    Directory of Open Access Journals (Sweden)

    Nicoleta Florina Mincă

    2017-06-01

    Full Text Available The paper is meant to be an approach to the use of nominal predicates in English and Romanian. In English there are two kinds of nominal predicates: the nominal predicate proper, concerned with the state or quality of the subject, and the double/complex predicate, which is a rather widespread form in English. In Romanian nominal predicates can be split into two categories: the proper nominal predicate, made up of a predicative and the copula “a fi” and the verbal nominal predicate, made up of a predicative and a lexical and grammatical copula. The predicative achievement within the nominal predicate structure is often similar to the subject achievement.

  13. Memoria del mal

    Directory of Open Access Journals (Sweden)

    Semprún, Jorge

    2011-06-01

    Full Text Available In May 2003 the twelfth edition of the «Aranguren Conferences» was held. Jorge Semprún gave three keynote speeches titled «Kant and the Maquis’ rucksack», «The radical evil and the Buchenwald latrines» and «Literature and memory of the evil: from Sartre to Paul Ricoeur», all of them grouped under the generic denomination Memory of Evil. The thread running through the three speeches was Semprún’s experience as a political deportee at Buchenwald concentration camp, so close to the Weimar camp of Schiller and Goethe. There, he could experience the radical evil, but also the brotherhood through the antifascist resistance groups who coordinated the various clandestine political groups at the camp. This experience helped him review some of the philosophical readings he had done as a philosphy student at the Sorbonne, as well as those readings he took an interest in following the end of the war. In this way, Semprún went over various authors (Immanuel Kant, André Malraux, Edmund Husserl, Jacques Maritain, Martin Heidegger, Karl Marx, Hannah Arendt, Jean Paul Sartre, Paul Ricoeur or Primo Levi arguing their relationship with the issue of Evil.

    En mayo de 2003 se celebró la duodécima edición de las «Conferencias Aranguren». Jorge Semprún dictó tres conferencias magistrales tituladas «Kant y la mochila del maquis», «El mal radical y las letrinas de Buchenwald» y «Literatura y memoria del mal: de Sartre a Paul Ricoeur», agrupadas todas ellas bajo el título genérico de Memoria del mal. El hilo conductor de las tres intervenciones fue la experiencia de Semprún como deportado político en el campo de concentración de Buchenwald, tan cercano al Weimar de Schiller y Goethe. Allí pudo experimentar el mal radical, pero también la fraternidad, a través de los grupos de resistencia antifascista que coordinaban en el campo los distintos grupos políticos clandestinos. Esta experiencia le sirvió para repasar las lecturas

  14. Relations as Plural-Predications in Plato

    OpenAIRE

    Scaltsas, Theodore

    2013-01-01

    Plato was the first philosopher to discover the metaphysical phenomenon of plural-subjects and plural-predication; e.g. you and I are two, but neither you, nor I are two. I argue that Plato devised an ontology for plural-predication through his Theory of Forms, namely, plural-partaking in a Form. Furthermore, I argue that Plato used plural-partaking to offer an ontology of related individuals without reifying relations. My contention is that Plato’s theory of plural-relatives has evaded detec...

  15. There is no such Thing as Predication

    Czech Academy of Sciences Publication Activity Database

    Peregrin, Jaroslav

    2011-01-01

    Roč. 40, č. 97 (2011), s. 29-51 ISSN 0010-5155 R&D Projects: GA ČR(CZ) GAP401/10/0146 Institutional support: RVO:67985955 Keywords : predication * inferential roles Subject RIV: AA - Philosophy ; Religion

  16. The first order fuzzy predicate logic (I)

    International Nuclear Information System (INIS)

    Sheng, Y.M.

    1986-01-01

    Some analysis tools of fuzzy measures, Sugeno's integrals, etc. are introduced into the semantic of the first order predicate logic to explain the concept of fuzzy quantifiers. The truth value of a fuzzy quantification proposition is represented by Sugeno's integral. With this framework, several important notions of formation rules, fuzzy valutions and fuzzy validity are discussed

  17. A note on extending decision algorithms by stable predicates

    Directory of Open Access Journals (Sweden)

    Alfredo Ferro

    1988-11-01

    Full Text Available A general mechanism to extend decision algorithms to deal with additional predicates is described. The only conditions imposed on the predicates is stability with respect to some transitive relations.

  18. A Graph Calculus for Predicate Logic

    Directory of Open Access Journals (Sweden)

    Paulo A. S. Veloso

    2013-03-01

    Full Text Available We introduce a refutation graph calculus for classical first-order predicate logic, which is an extension of previous ones for binary relations. One reduces logical consequence to establishing that a constructed graph has empty extension, i. e. it represents bottom. Our calculus establishes that a graph has empty extension by converting it to a normal form, which is expanded to other graphs until we can recognize conflicting situations (equivalent to a formula and its negation.

  19. From Concepts to Predicates within Constructivist Epistemology

    DEFF Research Database (Denmark)

    Badie, Farshad

    2017-01-01

    Constructivism is a philosophical approach that appears in a variety of guises, some of them pedagogical, some epistemological and some in complex combinations. This article is based on constructivist epistemology. More specifically, constructivist epistemology provides a ground for conceptual an...... analysis of humans’ concept constructions, conceptions and concept learning processes. It will focus on conceptual specification and logical description of a flow from concepts to predicates....

  20. Representational System Predicate Use and Convergence in Counseling: Gloria Revisited.

    Science.gov (United States)

    Mercier, Mary Ann; Johnson, Marilyn

    1984-01-01

    Analayzed transcripts of Three Approaches to Psychotherapy (Shostrom, 1966) for counselor and client representational system predicate use. Although different patterns of predicate use emerged, only limited support for Neurolinguistic Programming theory was found. The findings of different patterns of predicate use were related to convergence and…

  1. Predicative possession in Medieval Slavic Bible translations Predicative Possession in Early Biblical Slavic

    Directory of Open Access Journals (Sweden)

    Julia McAnallen

    2011-08-01

    Full Text Available Late Proto-Slavic (LPS had an inventory of three constructions for expressing predicative possession. Using the earliest Slavic Bible translations from Old Church Slavic (OCS, and to a lesser degree Old Czech, a number of conclusions can be drawn about the status of predicative possession for LPS. The verb iměti ‘have’ was the most frequent and least syntactically and semantically restricted predicative possessive construction (PPC. Existential PPCs with a dative possessor appear primarily with kinship relations, abstract possessums, and in a number of other fixed construction types; existential PPCs with the possessor in an u + genitive prepositional phrase primarily appear with concrete and countable possessums. Both existential PPCs call for an animate, most often pronominal, possessor. The u + genitive was the rarest type of PPC in LPS, though it had undoubtedly grammaticalized as a PPC.

  2. Justifying Objective Bayesianism on Predicate Languages

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    Jürgen Landes

    2015-04-01

    Full Text Available Objective Bayesianism says that the strengths of one’s beliefs ought to be probabilities, calibrated to physical probabilities insofar as one has evidence of them, and otherwise sufficiently equivocal. These norms of belief are often explicated using the maximum entropy principle. In this paper we investigate the extent to which one can provide a unified justification of the objective Bayesian norms in the case in which the background language is a first-order predicate language, with a view to applying the resulting formalism to inductive logic. We show that the maximum entropy principle can be motivated largely in terms of minimising worst-case expected loss.

  3. The Necessary Predication between State and Law

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    Daniel Nunes Pereira

    2017-02-01

    Full Text Available This study aims to demonstrate that the central idea of "rule of law" is per se redundant since there is a necessary and reciprocal predication between terms. It is based on the "State-Law" historical and philosophically founded (Westphalia, Bodin and Hobbes, phenomenologically (Schmitt’s Political Theology and normatively (Hans Kelsen’s Legal Positivism based. The rationale on the Sstate leading role suggests that State power must be complete to achieve its goals, which is given by normativity. It is clear that both, State and Law, have the same substance, "Sovereignty", whose implementation coincides with the human agency of cognitive reconfiguration of Politics by religious thought.

  4. El Gobierno del mal menor

    DEFF Research Database (Denmark)

    Agustin, Oscar Garcia

    2012-01-01

    El Gobierno no aspira a ser bueno ni malo. Se conforma con ser el Gobierno del mal menor, cuyas medidas drásticas y poco populares están destinadas a salvar a los ciudadanos del desastre que no ha llegado todavía pero podría llegar....

  5. Spatial Relation Predicates in Topographic Feature Semantics

    Science.gov (United States)

    Varanka, Dalia E.; Caro, Holly K.

    2013-01-01

    Topographic data are designed and widely used for base maps of diverse applications, yet the power of these information sources largely relies on the interpretive skills of map readers and relational database expert users once the data are in map or geographic information system (GIS) form. Advances in geospatial semantic technology offer data model alternatives for explicating concepts and articulating complex data queries and statements. To understand and enrich the vocabulary of topographic feature properties for semantic technology, English language spatial relation predicates were analyzed in three standard topographic feature glossaries. The analytical approach drew from disciplinary concepts in geography, linguistics, and information science. Five major classes of spatial relation predicates were identified from the analysis; representations for most of these are not widely available. The classes are: part-whole (which are commonly modeled throughout semantic and linked-data networks), geometric, processes, human intention, and spatial prepositions. These are commonly found in the ‘real world’ and support the environmental science basis for digital topographical mapping. The spatial relation concepts are based on sets of relation terms presented in this chapter, though these lists are not prescriptive or exhaustive. The results of this study make explicit the concepts forming a broad set of spatial relation expressions, which in turn form the basis for expanding the range of possible queries for topographical data analysis and mapping.

  6. Semantic role labeling for protein transport predicates

    Directory of Open Access Journals (Sweden)

    Martin James H

    2008-06-01

    Full Text Available Abstract Background Automatic semantic role labeling (SRL is a natural language processing (NLP technique that maps sentences to semantic representations. This technique has been widely studied in the recent years, but mostly with data in newswire domains. Here, we report on a SRL model for identifying the semantic roles of biomedical predicates describing protein transport in GeneRIFs – manually curated sentences focusing on gene functions. To avoid the computational cost of syntactic parsing, and because the boundaries of our protein transport roles often did not match up with syntactic phrase boundaries, we approached this problem with a word-chunking paradigm and trained support vector machine classifiers to classify words as being at the beginning, inside or outside of a protein transport role. Results We collected a set of 837 GeneRIFs describing movements of proteins between cellular components, whose predicates were annotated for the semantic roles AGENT, PATIENT, ORIGIN and DESTINATION. We trained these models with the features of previous word-chunking models, features adapted from phrase-chunking models, and features derived from an analysis of our data. Our models were able to label protein transport semantic roles with 87.6% precision and 79.0% recall when using manually annotated protein boundaries, and 87.0% precision and 74.5% recall when using automatically identified ones. Conclusion We successfully adapted the word-chunking classification paradigm to semantic role labeling, applying it to a new domain with predicates completely absent from any previous studies. By combining the traditional word and phrasal role labeling features with biomedical features like protein boundaries and MEDPOST part of speech tags, we were able to address the challenges posed by the new domain data and subsequently build robust models that achieved F-measures as high as 83.1. This system for extracting protein transport information from Gene

  7. AN EXPERIMENT WITH THE USE OF PREDICATE TRANSFORMERS IN UNITY

    NARCIS (Netherlands)

    DIJKSTRA, RM

    1995-01-01

    Recent work on UNITY is directed towards replacing the relations from UNITY logic by predicated transformers. In one of his Notes on UNITY. Jayadev Misra uses UNITY logic to prove a theorem about dynamic graphs. In this paper we use predicate transformers to prove the same theorem. We consider the

  8. Lecture Note on Discrete Mathematics: Predicates and Quantifiers

    DEFF Research Database (Denmark)

    Nordbjerg, Finn Ebertsen

    2016-01-01

    This lecture note supplements the treatment of predicates and quantifiers given in standard textbooks on Discrete Mathematics (e.g.: [1]) and introduces the notation used in this course. We will present central concepts that are important, when predicate logic is used for specification...

  9. Graph-Based Methods for Discovery Browsing with Semantic Predications

    DEFF Research Database (Denmark)

    Wilkowski, Bartlomiej; Fiszman, Marcelo; Miller, Christopher M

    2011-01-01

    . Poorly understood relationships may be explored through novel points of view, and potentially interesting relationships need not be known ahead of time. In a process of "cooperative reciprocity" the user iteratively focuses system output, thus controlling the large number of relationships often generated...... in literature-based discovery systems. The underlying technology exploits SemRep semantic predications represented as a graph of interconnected nodes (predication arguments) and edges (predicates). The system suggests paths in this graph, which represent chains of relationships. The methodology is illustrated...

  10. Automatic Predicate Argument Analysis of the Penn TreeBank

    National Research Council Canada - National Science Library

    Palmer, Martha; Rosenzweig, Joseph; Cotton, Scott

    2001-01-01

    ... had/presided over a meeting/conference with B There are several different lexical items that can be used to refer to the same type of event, and several different predicate argument patterns that can be...

  11. Temporal construals of bare predicates in Mandarin Chinese

    NARCIS (Netherlands)

    Sun, Hongyuan

    2014-01-01

    This dissertation contributes to the research on tense and eventualities across languages. It presents the first systematic investigation and detailed theoretical analysis of the temporal interpretations of sentences with bare (aspectually unmarked) predicates in Mandarin. Traditionally considered

  12. Matching therapists' predicates: an in vivo test of effectiveness.

    Science.gov (United States)

    Dowd, E T; Hingst, A G

    1983-08-01

    The theory of neurolinguistic programming predicts that a therapist's matching of a client's primary representational system, as expressed in the client's predicates, should result in increased therapist's rapport and social influence. This hypothesis was tested in an actual interview situation. Six relatively inexperienced therapists, two each in predicate matching, predicate mismatching, and predicate no-matching conditions, conducted a 30-min. interview with nine undergraduate student volunteers each, for a total of 54 subjects. After the appropriate interview condition was completed, subjects rated ther therapists on the Counselor Rating Form and the Counseling Evaluation Inventory. No significant differences among the three conditions on any of the measures were found. Results are compared with those of previous research on assessment and primary representational matching in analogue situations.

  13. Automated Predicate Abstraction for Real-Time Models

    Directory of Open Access Journals (Sweden)

    Bahareh Badban

    2009-11-01

    Full Text Available We present a technique designed to automatically compute predicate abstractions for dense real-timed models represented as networks of timed automata. We use the CIPM algorithm in our previous work which computes new invariants for timed automata control locations and prunes the model, to compute a predicate abstraction of the model. We do so by taking information regarding control locations and their newly computed invariants into account.

  14. Toward a unified analysis of terms and predications

    DEFF Research Database (Denmark)

    Rijkhoff, Jan

    1990-01-01

    Aristotle stated that movement or change "[...] pertain[s] exclusively to quality, quantity, and locality, each of which embraces contrasts" (Physics, V. II; see also Rijksbaron 1989). I will argue that operators as well as satellites, both in the term phrase and in the predication, can be charac...

  15. Le Predicat Adjectif en Esperanto (The Predicate Adjective in Esperanto)

    Science.gov (United States)

    Lo Jocomo, Francois

    1977-01-01

    A study of the predicate adjective in Esperanto based on the opposition established between the complementary classifications, monemes and words. Because morphological complications do not exist in Esperanto, study of the two classifications could proceed to the benefit of the study of other languages. (Text is in French.) (AMH)

  16. Predication and the Problem of Universals | Legg | Philosophical ...

    African Journals Online (AJOL)

    This paper contrasts the scholastic realisms of David Armstrong and Charles Peirce. It is argued that the so-called 'problem of universals' is not a problem in pure ontology (concerning whether universals exist) as Armstrong construes it to be. Rather, it extends to issues concerning which predicates should be applied where, ...

  17. El mal de ojo en Toledo

    OpenAIRE

    Salvador Hernández, Pedro Pablo

    2017-01-01

    La presente tesis doctoral estudia el fenómeno del Mal de Ojo en la provincia de Toledo desde una perspectiva antropológica. El trabajo se estructura en tres partes. Por un lado, se analiza el marco general de la antropología médica, la medicina popular, el curanderismo y los síndromes culturales. Por otro lado, se aborda el fenómeno del Mal de Ojo, analizando los síntomas, la etiología, el tratamiento y la prevención de esta enfermedad cultural. La tercera parte recoge cuatro estudios de cas...

  18. Analysis of refrigerant mal-distribution

    DEFF Research Database (Denmark)

    Kærn, Martin Ryhl; Elmegaard, Brian

    2009-01-01

    to be two straight tubes. The refrigerant maldistribution is then induced to the evaporator by varying the vapor quality at the inlet to each tube and the air-flow across each tube. Finally it is shown that mal-distribution can be compensated by an intelligent distributor, that ensures equal superheat...

  19. Argument-predicate distance as a filter for enhancing precision in extracting predications on the genetic etiology of disease

    Directory of Open Access Journals (Sweden)

    Lang François-Michel

    2006-06-01

    Full Text Available Abstract Background Genomic functional information is valuable for biomedical research. However, such information frequently needs to be extracted from the scientific literature and structured in order to be exploited by automatic systems. Natural language processing is increasingly used for this purpose although it inherently involves errors. A postprocessing strategy that selects relations most likely to be correct is proposed and evaluated on the output of SemGen, a system that extracts semantic predications on the etiology of genetic diseases. Based on the number of intervening phrases between an argument and its predicate, we defined a heuristic strategy to filter the extracted semantic relations according to their likelihood of being correct. We also applied this strategy to relations identified with co-occurrence processing. Finally, we exploited postprocessed SemGen predications to investigate the genetic basis of Parkinson's disease. Results The filtering procedure for increased precision is based on the intuition that arguments which occur close to their predicate are easier to identify than those at a distance. For example, if gene-gene relations are filtered for arguments at a distance of 1 phrase from the predicate, precision increases from 41.95% (baseline to 70.75%. Since this proximity filtering is based on syntactic structure, applying it to the results of co-occurrence processing is useful, but not as effective as when applied to the output of natural language processing. In an effort to exploit SemGen predications on the etiology of disease after increasing precision with postprocessing, a gene list was derived from extracted information enhanced with postprocessing filtering and was automatically annotated with GFINDer, a Web application that dynamically retrieves functional and phenotypic information from structured biomolecular resources. Two of the genes in this list are likely relevant to Parkinson's disease but are not

  20. Kewenangan Baitul Mal Aceh dalam Pendistribusian Zakat

    Directory of Open Access Journals (Sweden)

    Surya Darma

    2017-08-01

    ABSTRACT: Aceh is a province in Indonesia that is granted a special authority to govern and manage its own government affairs. One of them is zakat as one of the original source of income. Baitul Mal institution is established by qanun (local law to manage the zakat fund. In regard with its management procedure as the original revenue of the area, which is managed by Baitul Mal, is regulated in qanun and governor regulation. Its expenditure or distribution is in accordance with the guidance of the Islamic Sharia, that is, it may only be the part specified in the Qur'an, not for others. One of the forms of its distributions’ forms is the provision of vocational capital to productive zakat recipients through Productive Zakat Management Units. It is done in the form of interest-free loans. It is slightly different, as the zakat must be divided in full without needing to be returned. Although its interest-free loan is legal, it requires further explanation to avoid negative views. The finding shows that in 2013, 2014 and 2015, Baitul Mal Aceh, gains its funds more than expected. It requires careful handling in order to avoid  any problems in the future.

  1. Towards a Formal Occurrence Logic based on Predicate Logic

    DEFF Research Database (Denmark)

    Badie, Farshad; Götzsche, Hans

    2015-01-01

    In this discussion we will concentrate on the main characteristics of an alternative kind of logic invented by Hans Götzsche: Occurrence Logic, which is not based on truth functionality. Our approach is based on temporal logic developed and elaborated by A. N. Prior. We will focus on characterising...... argumentation based on formal Occurrence Logic concerning events and occurrences, and illustrate the relations between Predicate Logic and Occurrence Logic. The relationships (and dependencies) is conducive to an approach that can analyse the occurrences of ”logical statements based on different logical...... principles” in different moments. We will also conclude that the elaborated Götzsche’s Occurrence Logic could be able to direct us to a truth-functional independent computer-based logic for analysing argumentation based on events and occurrences....

  2. Mal, daño y justicia

    Directory of Open Access Journals (Sweden)

    Carlos THIEBAUT

    2009-11-01

    Full Text Available RESUMEN: Algunas experiencias del siglo XX -Auschwitz, el Gulag, Hiroshima- han vuelto a herir la conciencia ilustrada y replanteado el problema del mal en nuestra cultura. Más que una indagación metafísica sobre la naturaleza del mal, el artículo aboga por un análisis de cómo llegamos a elaborar su experiencia, un proceso que aquí prefiere concebirse como una indagación en torno al daño. Se analizan las estructuras conceptuales, modales y temporales de esa experiencia y, en la segunda parte, se propone la idea de que la elaboración pública del daño es una clave para comprender la dimensión normativa del espacio público.ABSTRACT: Some experiences of the Twentieth Century have, yet again, wounded the Enlightment program and have rephrased the problem of evil in our culture. The article avoids a metaphysical inquiry into the essence of evil and proposes an analysis of how we come to work and elabórate its experience, a process that is here understood as the experience of harm. Its conceptual, modal and temporal structures are analysed and, in its second part, the idea that the public labouring of harm is a clue to understanding the normative dimensión of the public sphere is proposed.

  3. Checking Consistency of C and Verilog using Predicate Abstraction and Induction

    National Research Council Canada - National Science Library

    Clarke, Edmund; Kroening, Daniel

    2004-01-01

    .... In contrast to existing tools that perform predicate abstraction, our approach is SAT-based and allows all ANSI-C and Verilog operators in the predicates. We report experimental results on an out-of-order RISC processor. We compare the performance of the new technique to Bounded Model Checking (BMC).

  4. Non-leftmost Unfolding in Partial Evaluation of Logic Programs with Impure Predicates

    DEFF Research Database (Denmark)

    Albert, Elvira; Puebla, German; Gallagher, John Patrick

    2006-01-01

    -leftmost unfolding steps can result in incorrect results since the independence of the computation rule no longer holds in the presence of impure predicates. Existing proposals allow non-leftmost unfolding steps, but at the cost of accuracy: bindings and failure are not propagated backwards to predicates which...

  5. Neurolinguistic Programming: The Impact of Imagery Tasks on Sensory Predicate Usage.

    Science.gov (United States)

    Graunke, Bruce; Roberts, T. Kevin

    1985-01-01

    Investigated the impact of varied imagining tasks on individuals' use of sensory predicates. Results demonstrated that subjects were able to vary their type of sensory predicates according to the task demands or situational context. Findings are incongruent with Bandler and Grinder's (1979) conceptualization of representational systems.…

  6. Mental Imagery as Revealed by Eye Movements and Spoken Predicates: A Test of Neurolinguistic Programming.

    Science.gov (United States)

    Elich, Matthew; And Others

    1985-01-01

    Tested Bandler and Grinder's proposal that eye movement direction and spoken predicates are indicative of sensory modality of imagery. Subjects reported images in the three modes, but no relation between imagery and eye movements or predicates was found. Visual images were most vivid and often reported. Most subjects rated themselves as visual,…

  7. Savoir gérer le mal

    Directory of Open Access Journals (Sweden)

    Michel Maffesoli

    2015-09-01

    Full Text Available Le sens commun, conservatoire immémorial de la sagesse humaine « sait », de savoir incorporé, que le mal, l’ombre, la mort, la douleur sont des caractéristiques essentielles de l’existence en son entièreté. Dès lors les créatures quelles qu’elles soient, sont des manifestations de la vie et, dès lors, méritent une attitude « compassionnelle », fraternelle, parce qu’ensemble elles constituent le flux vital. C’est ainsi que l’on peut comprendre l’utilité sociale de ces divers « mondes intermédiaires » que sont les croyances, religieuses ou philosophiques, au « double », au « daimon », aux esprits et autres figures tutélaires ou effrayantes. Elles aident à vivre, au jour le jour, la souffrance en la communalisant.

  8. Predicate Argument Structure Analysis for Use Case Description Modeling

    Science.gov (United States)

    Takeuchi, Hironori; Nakamura, Taiga; Yamaguchi, Takahira

    In a large software system development project, many documents are prepared and updated frequently. In such a situation, support is needed for looking through these documents easily to identify inconsistencies and to maintain traceability. In this research, we focus on the requirements documents such as use cases and consider how to create models from the use case descriptions in unformatted text. In the model construction, we propose a few semantic constraints based on the features of the use cases and use them for a predicate argument structure analysis to assign semantic labels to actors and actions. With this approach, we show that we can assign semantic labels without enhancing any existing general lexical resources such as case frame dictionaries and design a less language-dependent model construction architecture. By using the constructed model, we consider a system for quality analysis of the use cases and automated test case generation to keep the traceability between document sets. We evaluated the reuse of the existing use cases and generated test case steps automatically with the proposed prototype system from real-world use cases in the development of a system using a packaged application. Based on the evaluation, we show how to construct models with high precision from English and Japanese use case data. Also, we could generate good test cases for about 90% of the real use cases through the manual improvement of the descriptions based on the feedback from the quality analysis system.

  9. Parts of Speech in Non-typical Function: (Asymmetrical Encoding of Non-verbal Predicates in Erzya

    Directory of Open Access Journals (Sweden)

    Rigina Turunen

    2011-01-01

    Full Text Available Erzya non-verbal conjugation refers to symmetric paradigms in which non-verbal predicates behave morphosyntactically in a similar way to verbal predicates. Notably, though, non-verbal conjugational paradigms are asymmetric, which is seen as an outcome of paradigmatic neutralisation in less frequent/less typical contexts. For non-verbal predicates it is not obligatory to display the same amount of behavioural potential as it is for verbal predicates, and the lexical class of non-verbal predicate operates in such a way that adjectival predicates are more likely to be conjugated than nominals. Further, besides symmetric paradigms and constructions, in Erzya there are non-verbal predicate constructions which display a more overt structural encoding than do verbal ones, namely, copula constructions. Complexity in the domain of non-verbal predication in Erzya decreases the symmetry of the paradigms. Complexity increases in asymmetric constructions, as well as in paradigmatic neutralisation when non-verbal predicates cannot be inflected in all the tenses and moods occurring in verbal predication. The results would be the reverse if we were to measure complexity in terms of the morphological structure. The asymmetric features in non-verbal predication are motivated language-externally, because non-verbal predicates refer to states and occur less frequently as predicates than verbal categories. The symmetry of the paradigms and constructions is motivated language-internally: a grammatical system with fewer rules is economical.

  10. Arendt, Eichmann y la banalidad del mal

    Directory of Open Access Journals (Sweden)

    López, Marina

    2010-04-01

    Full Text Available In this text I describe the characteristics that Hannah Arendt attributes to the SS agents through the figure of Eichmann, during the German Nazi regime of the 20th century. According to this characterization, I intend to show, on the one hand, that there is not a break in Arendt’s thought on evil, i.e. from The Origins of Totalitarianism to Eichmann in Jerusalem: a report on the banality of evil, but a continuous line of thought. And, on the other hand, I try to follow the clues that Arendt gives concerning the “banality” that defines the behavior of individuals such as Eichmann. Both premises will permit me to point out what, in my understanding, the banalization of humanity implies, not only in the context of the Jewish Holocaust, but in each of the societies in which the elimination of spontaneity is a reality.

    En el texto se describen las características que Hannah Arendt, a través de la figura de Eichmann, atribuye a los agentes SS durante el régimen nazi alemán de mediados del siglo XX. Con la caracterización se persigue mostrar, en principio, que no hay una ruptura en el pensamiento de Hannah Arendt respecto a su manera de considerar el mal, desde Los orígenes del Totalitarismo hasta Eichmann en Jerusalén, un estudio sobre la banalidad del mal, sino una continuidad y, por otra parte, seguir las pistas que Arendt propone en torno a la “banalidad” que define el comportamiento de individuos como Eichmann. Ambas premisas nos permitirán poner de relieve lo que, a nuestro parecer, implica la banalización de la humanidad no sólo en el contexto del Holocausto judío, sino en cada una de las sociedades en las que la eliminación de la espontaneidad es una realidad.

  11. Intestinal mal-rotation in adults. CT findings

    International Nuclear Information System (INIS)

    Vazquez Munoz, Enrique; Ramiro Ramiro, Esther; Perez Villacastin, Benjamin; Learra Martinez, Maria C.; Franco Lopez, Maria A.

    2004-01-01

    We review 7 adult cases of intestinal mal-rotation who were studied with CT. All patients had a small bowel located in the right hemi abdomen, abnormal location of superior mesenteric vein relative to superior mesenteric artery. Superior mesenteric vein was located anteriorly and to the left of superior mesenteric artery. In patients who suffered intestinal volvulus a 'whirlpool' sign was observed, due to the helicoidal torsion of the intestine and mesentery surrounding superior mesenteric artery. In 3 cases CT demonstrated absence or poor development of the pancreas uncinate process. In 2 patients CT revealed polysplenia. CT played a major role in 3 patients with volvulus as a complication of intestinal mal-rotation. CT also demonstrated unsuspected mal-rotation in one asymptomatic patient. In 3 cases with classic symptoms CT confirmed the intestinal mal-rotation diagnosed by barium studies. (author)

  12. PENGARUH KEBUDAYAAN KONTEMPORER DALAM PERANCANGAN ARSITEKTUR MAL

    Directory of Open Access Journals (Sweden)

    Freddy H. Istanto

    2000-01-01

    Full Text Available Market is traditionally known as the place where the seller and the buyers meet. In its development, it grows to be big shopping centers and even malls. Along with it, the concept of market has also changed within this building. It is not only the place where the transaction between the sellers and the buyers happen but also it expands to be the one where each person has turned to be the "player" in the nowadays "cultural-theatre". Being the designers, the architect is challenged to respond the changing pattern in the society by making use of the building. Abstract in Bahasa Indonesia : Pasar dikenal sebagai tempat dimana penjual dan pembeli bertemu. Dalam perkembangan lebih lanjut muncul pusat-pusat pertokoan yang sangat besar sampai hadirnya shopping-mall. Di dalam bangunan inilah konsep pasar secara tradisional telah berkembang, tidak saja tempat transaksi antara penjual dan pembeli, tetapi telah melebar menjadi tempat dimana setiap individu telah menjadi "pemain" di dalam sebuah teater kebudayaan masa kini. Arsitek sebagai perancang bangunan harus menyikapi perubahan-perubahan perilaku yang terjadi di masyarakat dalam menggunakan bangunannya. Kata kunci: kebudayaan kontemporer, arsitek, arsitektur mal, kebudayaan milenium tiga.

  13. THE CREATION OF ANALYTICAL PREDICATION CONCEPT IN MULTILEVEL ORGANIZATION SYSTEM MANAGEMENT

    Directory of Open Access Journals (Sweden)

    O. M. Pisareva

    2013-01-01

    Full Text Available This article deals with analytical and forecasting methodology problems in the integrated business systems management. The theoretical framework of analytical predication concept in multilevel organization systems is presented.

  14. Semantic motivation for the denotational identity of arguments in predication structures

    Directory of Open Access Journals (Sweden)

    Viara Maldjieva

    2015-11-01

    Full Text Available Semantic motivation for the denotational identity of arguments in predication structures This text is an attempt at a preliminary outline of the factors that motivate the denotational identity of argument content in the predication structure as well as the consequences of this identity for the shape of the sentence expression which is a realization of such a structure. The first question this analysis attempts to answer concerns the structure of predicative concepts that constitute the predication structure with arguments of the identical content? The second question the cursory analysis done attempts to answer concerns the manner, in which the identity existing on the semantic structure level is signaled on the surface, in the formal structure.

  15. The Agreement between Conjoined Subjects and Predicate: Croatian Church Slavonic Corpus Analysis

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    Ana Kovačević

    2017-08-01

    Full Text Available The abundance of grammatical categories in Slavonic and their overlap are particularly evident in the agreement between conjoined subjects and predicate. When they are accompanied by agreement conditions, such as word order and animacy in Slavic languages, different agreement patterns, dependent also on concrete context and speaker, are to be expected. In this paper the study of the agreement between conjoined subjects and predicate is based on an analysis of the medieval Glagolitic Croatian Church Slavonic corpus. Number, gender, and person are grammatical categories, i. e., features of conjoined noun phrases and predicate agreement. The analysis includes noun phrases conjoined by coordinating and some non-coordinating conjunctions as well as noun phrases conjoined by a gradational ‛not only [. . .] but also’ structure. Comitative and reciprocal noun phrases are included as well. The research in the given corpus shows that the conjoined noun phrases with predicate agreement can be syntactic (predicate showing agreement with one conjunct or semantic (predicate showing agreement with all conjuncts. Syntactic agreement appears as the so-called contact agreement (predicate showing agreement with the closest conjunct and as distant agreement (predicate showing agreement with the most distant conjunct. Semantic agreement is applied mostly in accordance with G. G. Corbett’s resolution rules for Slavic languages. However, the analysis shows that some resolution rules for number should be revised due to dual number. Although absent from the majority of contemporary Slavic languages, it is precisely in historical Slavic idioms that dual number reveals its identity, highlighted in agreement study as well.

  16. Link predication based on matrix factorization by fusion of multi class organizations of the network

    OpenAIRE

    Jiao, Pengfei; Cai, Fei; Feng, Yiding; Wang, Wenjun

    2017-01-01

    Link predication aims at forecasting the latent or unobserved edges in the complex networks and has a wide range of applications in reality. Almost existing methods and models only take advantage of one class organization of the networks, which always lose important information hidden in other organizations of the network. In this paper, we propose a link predication framework which makes the best of the structure of networks in different level of organizations based on nonnegative matrix fac...

  17. Genomic characterization and linkage mapping of the apple allergen genes Mal d 2 (thaumatin-like protein) and Mal d 4 (profilin)

    NARCIS (Netherlands)

    Gao, Z.S.; Weg, van de W.E.; Schaart, J.G.; Arkel, van G.; Breiteneder, H.; Hoffmann-Sommergruber, K.; Gilissen, L.J.W.J.

    2005-01-01

    Four classes of apple allergens (Mal d 1, ¿2, ¿3 and ¿4) have been reported. By using PCR cloning and sequencing approaches, we obtained genomic sequences of Mal d 2 (thaumatin-like protein) and Mal d 4 (profilin) from the cvs Prima and Fiesta, the two parents of a European reference mapping

  18. AKSESIBILITAS HOTEL HORISON BEKASI DENGAN MAL METROPOLITAN

    Directory of Open Access Journals (Sweden)

    Nadia Nursintia

    2016-03-01

    Full Text Available Abstract - Development of accommodation services is growing very fast, the construction of hotels ranging from low to star property confirms that the business is very profitable and promising. Growing hotel development as the presence and development of tourism in a region. Concept of mix used and are now growing in demand by developers. In addition to shorten the land, its facilities are increasingly in demand, because the concept of developing the land into two business buildings comprising the hotel and mall, can provide ease of access for service users to carry out all the activities that support their activities. Accessibility is a very important thing to be considered for the service users to choose the hotel accommodation that will be flown them. Distance, transportation, facilities, road conditions, and ease of location had been the benchmark and consideration to get a suitable hotel for their activities.   Keyword : Accessibility, Hotel   Abstrak - Perkembangan jasa akomodasi saat ini berkembang sangat cepat, dibangunnya hotel mulai dari hotel rendah hingga bintang menegaskan bahwa bisnis properti ini sangat menguntungkan dan menjanjikan. Pembangunan hotel berkembang seiring hadirnya dan berkembangnya pariwisata di suatu daerah. Konsep mix used pun kini semakin berkembang dan diminati oleh para pengembang. Selain karena mempersingkat lahan, fasilitas nya pun semakin diminati, karena konsep mengembangkan satu lahan menjadi dua bangunan usaha yang terdiri dari hotel dan mal, dapat memberikan kemudahan akses untuk para pengguna jasa untuk melakukan segala aktifitas yang mendukung kegiatannya. Aksesbilitas merupakan hal yang sangat penting yang menjadi pertimbangan bagi para pengguna jasa akomodasi untuk memilih hotel yang akan mereka singgahi. Jarak, transportasi, fasilitas, kondisi jalan, dan kemudahan lokasi lah yang menjadi tolak ukur dan pertimbangan untuk mendapatkan hotel yang cocok bagi kegiatan mereka.   Kata Kunci

  19. Mal de meleda with congenital cataract: A novel case report

    Directory of Open Access Journals (Sweden)

    Anisha Sethi

    2015-01-01

    Full Text Available Mal de meleda (MdM, a rare autosomal recessive genodermatosis is characterized by erythema and hyperkeratosis of the palms and soles with a sharp demarcation and that progress with age (progrediens and extend to the dorsal aspects of the hands and feet (transgrediens. It has been associated with various conditions albeit rarely with congenial cataract. Ocular lens and the skin have the same embryological origins. We hereby present this novel case report of Mal de meleda in association with congenital posterior subcapsular cataract which to the best of our knowledge has not been reported from India before.

  20. EXPANSION OF TURBO PROLOGUE PROGRAMMING SYSTEM BY PREDICATES FOR LIST PROCESSING

    Directory of Open Access Journals (Sweden)

    A. T. Kovalkov

    2008-01-01

    Full Text Available Lists are considered as a main data structure in logic Turbo Prologue programming language. However the language does not contain in-set predicates (procedures for list processing. In order to facilitate a problem programming process where lists are used it is proposed to apply a Turbo Prologue version that has a set of predicates in the form of recursive rules for executing frequently repeated operations with lists such as unification of lists, italicization and deletion of some list elements, sorting-out, list reversing and many others. The modified version contains a reference to new input predicates. The proposed Turbo Prologue version is easily expanded by new rules. Usage of this version makes programmer’s work easier and promotes development of new programs where it is necessary to work with lists.

  1. Evolution of mal ABC transporter operons in the Thermococcales and Thermotogales

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    Gogarten J Peter

    2008-01-01

    Full Text Available Abstract Background The mal genes that encode maltose transporters have undergone extensive lateral transfer among ancestors of the archaea Thermococcus litoralis and Pyrococcus furiosus. Bacterial hyperthermophiles of the order Thermotogales live among these archaea and so may have shared in these transfers. The genome sequence of Thermotoga maritima bears evidence of extensive acquisition of archaeal genes, so its ancestors clearly had the capacity to do so. We examined deep phylogenetic relationships among the mal genes of these hyperthermophiles and their close relatives to look for evidence of shared ancestry. Results We demonstrate that the two maltose ATP binding cassette (ABC transporter operons now found in Tc. litoralis and P. furiosus (termed mal and mdx genes, respectively are not closely related to one another. The Tc. litoralis and P. furiosus mal genes are most closely related to bacterial mal genes while their respective mdx genes are archaeal. The genes of the two mal operons in Tt. maritima are not related to genes in either of these archaeal operons. They are highly similar to one another and belong to a phylogenetic lineage that includes mal genes from the enteric bacteria. A unique domain of the enteric MalF membrane spanning proteins found also in these Thermotogales MalF homologs supports their relatively close relationship with these enteric proteins. Analyses of genome sequence data from other Thermotogales species, Fervidobacterium nodosum, Thermosipho melanesiensis, Thermotoga petrophila, Thermotoga lettingae, and Thermotoga neapolitana, revealed a third apparent mal operon, absent from the published genome sequence of Tt. maritima strain MSB8. This third operon, mal3, is more closely related to the Thermococcales' bacteria-derived mal genes than are mal1 and mal2. F. nodosum, Ts. melanesiensis, and Tt. lettingae have only one of the mal1-mal2 paralogs. The mal2 operon from an unknown species of Thermotoga appears to

  2. Potential Risk Estimation Drowning Index for Children (PREDIC): a pilot study from Matlab, Bangladesh.

    Science.gov (United States)

    Borse, N N; Hyder, A A; Bishai, D; Baker, T; Arifeen, S E

    2011-11-01

    Childhood drowning is a major public health problem that has been neglected in many low- and middle-income countries. In Matlab, rural Bangladesh, more than 40% of child deaths aged 1-4 years are due to drowning. The main objective of this paper was to develop and evaluate a childhood drowning risk prediction index. A literature review was carried out to document risk factors identified for childhood drowning in Bangladesh. The Newacheck model for special health care needs for children was adapted and applied to construct a childhood drowning risk index called "Potential Risk Estimation Drowning Index for Children" (PREDIC). Finally, the proposed PREDIC Index was applied to childhood drowning deaths and compared with the comparison group from children living in Matlab, Bangladesh. This pilot study used t-tests and Receiver Operating Characteristic (ROC) curve to analyze the results. The PREDIC index was applied to 302 drowning deaths and 624 children 0-4 years old living in Matlab. The results of t-test indicate that the drowned children had a statistically (t=-8.58, p=0.0001) significant higher mean PREDIC score (6.01) than those in comparison group (5.26). Drowning cases had a PREDIC score of 6 or more for 68% of the children however, the comparison group had 43% of the children with score of 6 or more which was statistically significant (t=-7.36, p<0.001). The area under the curve for the Receiver Operating Characteristic curve was 0.662. Index score construction was scientifically plausible; and the index is relatively complete, fairly accurate, and practical. The risk index can help identify and target high risk children with drowning prevention programs. PREDIC index needs to be further tested for its accuracy, feasibility and effectiveness in drowning risk reduction in Bangladesh and other countries. Copyright © 2011 Elsevier Ltd. All rights reserved.

  3. Lexical development of noun and predicate comprehension and production in isiZulu.

    Science.gov (United States)

    Nicolas, Ramona Kunene; Ahmed, Saaliha

    2016-07-28

    This study seeks to investigate the development of noun and predicate comprehension and production in isiZulu-speaking children between the ages of 25 and 36 months. It compares lexical comprehension and production in isiZulu, using an Italian developed and validated vocabulary assessment tool: The Picture Naming Game (PiNG) developed by Bello, Giannantoni, Pettenati, Stefanini and Caselli (2012). The PiNG tool includes four subtests, one each for subnoun comprehension (NC), noun production (NP), predicate comprehension (PC), and predicate production (PP). Children are shown these lexical items and then asked to show comprehension and produce certain lexical items. After adaptation into the South African context, the adapted version of PiNG was used to directly assess the lexical development of isiZulu with the three main objectives to (1) test the efficiency of the adaptation of a vocabulary tool to measure isiZulu comprehension and production development, (2) test previous findings done in many cross-linguistic comparisons that have found that both comprehension and production performance increase with age for a lesser-studied language, and (3) present our findings around the comprehension and production of the linguistic categories of nouns and predicates. An analysis of the results reported in this study show an age effect throughout the entire sample. Across all the age groups, the comprehension of the noun and predicate subtests was better performed than the production of noun and predicate subtests. With regard to lexical items, the responses of children showed an influence of various factors, including the late acquisition of items, possible problems with stimuli presented to them, and the possible input received by the children from their home environment.

  4. Lexical development of noun and predicate comprehension and production in isiZulu

    Directory of Open Access Journals (Sweden)

    Ramona Kunene Nicolas

    2016-07-01

    Full Text Available This study seeks to investigate the development of noun and predicate comprehension and production in isiZulu-speaking children between the ages of 25 and 36 months. It compares lexical comprehension and production in isiZulu, using an Italian developed and validated vocabulary assessment tool: The Picture Naming Game (PiNG developed by Bello, Giannantoni, Pettenati, Stefanini and Caselli (2012. The PiNG tool includes four subtests, one each for subnoun comprehension (NC, noun production (NP, predicate comprehension (PC, and predicate production (PP. Children are shown these lexical items and then asked to show comprehension and produce certain lexical items. After adaptation into the South African context, the adapted version of PiNG was used to directly assess the lexical development of isiZulu with the three main objectives to (1 test the efficiency of the adaptation of a vocabulary tool to measure isiZulu comprehension and production development, (2 test previous findings done in many cross-linguistic comparisons that have found that both comprehension and production performance increase with age for a lesser-studied language, and (3 present our findings around the comprehension and production of the linguistic categories of nouns and predicates. An analysis of the results reported in this study show an age effect throughout the entire sample. Across all the age groups, the comprehension of the noun and predicate subtests was better performed than the production of noun and predicate subtests. With regard to lexical items, the responses of children showed an influence of various factors, including the late acquisition of items, possible problems with stimuli presented to them, and the possible input received by the children from their home environment.

  5. A zase ta malá povodí...

    Czech Academy of Sciences Publication Activity Database

    Tesař, Miroslav

    2017-01-01

    Roč. 67, č. 8 (2017), s. 33-38 ISSN 1211-0760. [Hydrologie malého povodí 2017. Praha, 18.04.2017-20.04.2017] Institutional support: RVO:67985874 Keywords : small basin * experimental hydrology * water balance * conference * watershed * hydrology * watershed Subject RIV: DA - Hydrology ; Limnology OBOR OECD: Hydrology

  6. Development and evaluation of a biomedical search engine using a predicate-based vector space model.

    Science.gov (United States)

    Kwak, Myungjae; Leroy, Gondy; Martinez, Jesse D; Harwell, Jeffrey

    2013-10-01

    Although biomedical information available in articles and patents is increasing exponentially, we continue to rely on the same information retrieval methods and use very few keywords to search millions of documents. We are developing a fundamentally different approach for finding much more precise and complete information with a single query using predicates instead of keywords for both query and document representation. Predicates are triples that are more complex datastructures than keywords and contain more structured information. To make optimal use of them, we developed a new predicate-based vector space model and query-document similarity function with adjusted tf-idf and boost function. Using a test bed of 107,367 PubMed abstracts, we evaluated the first essential function: retrieving information. Cancer researchers provided 20 realistic queries, for which the top 15 abstracts were retrieved using a predicate-based (new) and keyword-based (baseline) approach. Each abstract was evaluated, double-blind, by cancer researchers on a 0-5 point scale to calculate precision (0 versus higher) and relevance (0-5 score). Precision was significantly higher (psearching than keywords, laying the foundation for rich and sophisticated information search. Copyright © 2013 Elsevier Inc. All rights reserved.

  7. Kill the Song--Steal the Show: What Does Distinguish Predicative Metaphors from Decomposable Idioms?

    Science.gov (United States)

    Caillies, Stephanie; Declercq, Christelle

    2011-01-01

    This study examined the semantic processing difference between decomposable idioms and novel predicative metaphors. It was hypothesized that idiom comprehension results from the retrieval of a figurative meaning stored in memory, that metaphor comprehension requires a sense creation process and that this process difference affects the processing…

  8. Boolean-Like and Frequentistic Nonstandard Semantics for First-Order Predicate Calculus without Functions

    Czech Academy of Sciences Publication Activity Database

    Kramosil, Ivan

    2001-01-01

    Roč. 5, č. 1 (2001), s. 45-57 ISSN 1432-7643 R&D Projects: GA AV ČR IAA1030803 Institutional research plan: AV0Z1030915 Keywords : first-order predicate calculus * standard semantics * Boolean-like semantics * frequentistic semantics * completness theorems Subject RIV: BA - General Mathematics

  9. Cipient Predication : Unifying Double Object, Dative Experiencer and Existential/Presentational Constructions

    NARCIS (Netherlands)

    Brandt, P.M.

    2003-01-01

    The principal claim of this dissertation is that there is a unique structural core shared by Double Object, Dative Experiencer and Existential/Presentational constructions. This core is argued to take the form of a Cipient Predication structure, `cipient covering traditional notions like (affected)

  10. Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migration.

    Science.gov (United States)

    Somogyi, Kálmán; Rørth, Pernille

    2004-07-01

    Cells migrating through a tissue exert force via their cytoskeleton and are themselves subject to tension, but the effects of physical forces on cell behavior in vivo are poorly understood. Border cell migration during Drosophila oogenesis is a useful model for invasive cell movement. We report that this migration requires the activity of the transcriptional factor serum response factor (SRF) and its cofactor MAL-D and present evidence that nuclear accumulation of MAL-D is induced by cell stretching. Border cells that cannot migrate lack nuclear MAL-D but can accumulate it if they are pulled by other migrating cells. Like mammalian MAL, MAL-D also responds to activated Diaphanous, which affects actin dynamics. MAL-D/SRF activity is required to build a robust actin cytoskeleton in the migrating cells; mutant cells break apart when initiating migration. Thus, tension-induced MAL-D activity may provide a feedback mechanism for enhancing cytoskeletal strength during invasive migration.

  11. Modelling of innovative SANEX process mal-operations

    International Nuclear Information System (INIS)

    McLachlan, F.; Taylor, R.; Whittaker, D.; Woodhead, D.; Geist, A.

    2016-01-01

    The innovative (i-) SANEX process for the separation of minor actinides from PUREX highly active raffinate is expected to employ a solvent phase comprising 0.2 M TODGA with 5 v/v% 1-octanol in an inert diluent. An initial extract / scrub section would be used to extract trivalent actinides and lanthanides from the feed whilst leaving other fission products in the aqueous phase, before the loaded solvent is contacted with a low acidity aqueous phase containing a sulphonated bis-triazinyl pyridine ligand (BTP) to effect a selective strip of the actinides, so yielding separate actinide (An) and lanthanide (Ln) product streams. This process has been demonstrated in lab scale trials at Juelich (FZJ). The SACSESS (Safety of Actinide Separation processes) project is focused on the evaluation and improvement of the safety of such future systems. A key element of this is the development of an understanding of the response of a process to upsets (mal-operations). It is only practical to study a small subset of possible mal-operations experimentally and consideration of the majority of mal-operations entails the use of a validated dynamic model of the process. Distribution algorithms for HNO_3, Am, Cm and the lanthanides have been developed and incorporated into a dynamic flowsheet model that has, so far, been configured to correspond to the extract-scrub section of the i-SANEX flowsheet trial undertaken at FZJ in 2013. Comparison is made between the steady state model results and experimental results. Results from modelling of low acidity and high temperature mal-operations are presented. (authors)

  12. O conceito de mal radical The concept of radical evil

    Directory of Open Access Journals (Sweden)

    Adriano Correia

    2005-01-01

    Full Text Available A noção de mal radical aparece em Kant no contexto da discussão da religião nos limites da simples razão e busca dar conta da complexa relação entre o respeito pela lei moral e o amor-próprio na definição do móbil para a ação. Na busca por identificar o fundamento da propensão para o mal no homem, Kant se vê diante da dificuldade de ter de articular natureza e liberdade, e ainda que a noção de mal radical possa conservar algumas ambigüidades, permite conceber uma noção de responsabilidade compatível com uma inata propensão para o mal. Neste texto busco explicitar alguns passos fundamentais na construção do conceito por Kant.The concept of radical evil appears in Kant's theory when he discusses the religion in the limits of the mere reason and aims explain the complex relationship between respect for the moral law and the self-love, for establish the motive of the action. By aiming identify the basis of human inclination to evil, Kant is faced with the trouble of have to put nature and freedom in connection. Despite of the concept of radical evil retain some ambiguity, it allows conceive a notion of responsibility suitable to an inherent inclination to evil. In this paper is my purpose to explain some basic moments of Kantian formulation of that notion.

  13. Kill the song—steal the show: what does distinguish predicative metaphors from decomposable idioms?

    Science.gov (United States)

    Caillies, Stéphanie; Declercq, Christelle

    2011-06-01

    This study examined the semantic processing difference between decomposable idioms and novel predicative metaphors. It was hypothesized that idiom comprehension results from the retrieval of a figurative meaning stored in memory, that metaphor comprehension requires a sense creation process and that this process difference affects the processing time of idiomatic and metaphoric expressions. In the first experiment, participants read sentences containing decomposable idioms, predicative metaphors or control expressions and performed a lexical decision task on figurative targets presented 0, 350, and 500 ms, or 750 after reading. Results demonstrated that idiomatic expressions were processed sooner than metaphoric ones. In the second experiment, participants were asked to assess the meaningfulness of idiomatic, metaphoric and literal expressions after reading a verb prime that belongs to the target phrase (identity priming). The results showed that verb identity priming was stronger for idiomatic expressions than for metaphor ones, indicating different mental representations.

  14. PREDICATE OF ‘MANGAN’ IN SASAK LANGUAGE: A STUDY OF NATURAL SEMANTIC METALANGUAGE

    Directory of Open Access Journals (Sweden)

    Sarwadi

    2016-11-01

    Full Text Available The aim of this study were to know semantic meaning of predicate Ngajengan, Daharan, Ngelor, Mangan, Ngrodok (Eating, Kaken (Eating, Suap, Bejijit, (Eating Bekeruak (Eating, Ngerasak (Eating and Nyangklok (Eating. Besides that, to know the lexical meaning of each words and the function of words in every sentences especially the meaning of eating in Sasaknese language. The lexical meaning of Ngajengan, Daharan, Ngelor, Mangan, Ngrodok (Eating, Kaken (Eating, Suap, Bejijit, (Eating Bekeruak (Eating, Ngerasak (Eating and Nyangklok (Eating was doing something to eat but the differences of these words are usage in sentences. Besides that, the word usage based on the subject and object and there is predicate that need tool to state eat meals or food.

  15. EARLY IDENTIFICATION OF SOFTWARE DEFECTS USING OCL PREDICATES TO IMPROVE SOFTWARE QUALITY

    Directory of Open Access Journals (Sweden)

    A. JALILA

    2015-03-01

    Full Text Available Formal specification-based testing has been used widely to assess potential faults or prove their absence in a given system at the earliest. This research work has proposed an automated fault-based testing framework to test the specification of the system using Object Constraint Language (OCL. Accordingly, the possible faults in OCL specification of the system has been anticipated by mutating its method based on OCL predicate-based fault classes. Then, test cases are generated using Genetic Algorithm with simulated annealing technique. In this paper, a novel OCL-predicate based fitness function is defined to evaluate the generated test data. Finally, this paper presents the experimental results, which indicate that the proposed methodology provides more test coverage with the reduced test suite and test run. This results in cost-effective software development so as to improve software quality.

  16. Predicate Offences of Money Laundering and Anti Money Laundering Practices in Bangladesh Among South Asian Countries

    Directory of Open Access Journals (Sweden)

    Islam Mohammad Saiful

    2017-12-01

    Full Text Available The purpose of the study is to identify the main reasons of money laundering in Bangladesh among the twenty seven predicate offences of money laundering prescribed by Bangladesh Bank and position of Bangladesh among South Asian Countries regarding anti-money laundering practices. Besides, an anti-money laundering model has been developed to combat against money laundering as 14 percent bankers think that only existing know your customer form and transaction profile of banking sector are not enough to detect money laundering. To conduct the study, 91 bankers have been surveyed to take response through structured questionnaire regarding their opinion about the predicate offences of money laundering and sufficiency of existing KYC form of banking sector to detect money laundering. From the responses, factor analysis, test of hypothesis, correlation and regression analysis have been conducted using SPSS software. The study identifies that predicate offences of money laundering can be minimized mainly through scrutinizing the activities of local criminals with foreign network and strict anti-corruption measures through automation in National Board of Revenue, strict policy adoption of criminal detection and support from foreign experts. Besides, regression model shows that only six predicate offences of money laundering explains 87.2 percent of money laundering that should get more emphasize to combat against money laundering. From the comparative analysis, it has been found that Bangladesh in holding better position just after India among six South Asian Countries according to Basel AML Index score. This study provides a complete understanding of the position of Bangladesh in case of money laundering and anti-money laundering practices. The integration of four domains, i.e. AML model development, factor analysis, econometric analysis and comparative analysis of AML index will provide insights to managers and policy makers about the money laundering

  17. Link predication based on matrix factorization by fusion of multi class organizations of the network.

    Science.gov (United States)

    Jiao, Pengfei; Cai, Fei; Feng, Yiding; Wang, Wenjun

    2017-08-21

    Link predication aims at forecasting the latent or unobserved edges in the complex networks and has a wide range of applications in reality. Almost existing methods and models only take advantage of one class organization of the networks, which always lose important information hidden in other organizations of the network. In this paper, we propose a link predication framework which makes the best of the structure of networks in different level of organizations based on nonnegative matrix factorization, which is called NMF 3 here. We first map the observed network into another space by kernel functions, which could get the different order organizations. Then we combine the adjacency matrix of the network with one of other organizations, which makes us obtain the objective function of our framework for link predication based on the nonnegative matrix factorization. Third, we derive an iterative algorithm to optimize the objective function, which converges to a local optimum, and we propose a fast optimization strategy for large networks. Lastly, we test the proposed framework based on two kernel functions on a series of real world networks under different sizes of training set, and the experimental results show the feasibility, effectiveness, and competitiveness of the proposed framework.

  18. Metaphysical Modality, Modality of Predicate and the Theory of "Decisive Necessity”

    Directory of Open Access Journals (Sweden)

    L. Nabavi

    2010-01-01

    Full Text Available Aristotle in the Organon (1949: 9,30 a ,15-19 explicitly states that in a categorical syllogism when the minor premise is absolute (without modality operator and the major is necessary, the conclusion will be necessary too. This Aristotle's view has been the source of many conflicts and disputes in the history of logic. The famous logicians and historians of logic in the twentieth century as "Nicholas Rescher" and "Becker" believe that Aristotle's view is justifiable and defensible (at least compared to the first figure only if, the modality of major premise is considered as the property of predicate (modality de re. Today, we know very well that the modality of predicate is closely linked to Metaphysical and philosophical Modality. “Shihab al-Din al- Suhrawardi” in the theory of "Decisive (Battateh Necessity” by accepting this base, explicitly states that, in the beginning, the modality must be mentioned as a part of the predicate and then the modality of relation or copula is summarized and reduced to necessity. The modern formalization of the most important part of this theory is as follows: ("x (àAx É à Bx º ("x □ (àAx É à BxThis paper discusses the historical overview of the metaphysical modality firstly and then shows that the theory of "Decisive Necessity” is true and justified in a model of modal logic with equivalent accessibility relation and homogeneous possible world view (fixed domain.

  19. PREDICE score as a predictor of 90 days mortality in patients with heart failure

    Science.gov (United States)

    Purba, D. P. S.; Hasan, R.

    2018-03-01

    Hospitalization in chronic heart failure patients associated with high mortality and morbidity rate. The 90 days post-discharge period following hospitalization in heart failure patients is known as the vulnerable phase, it carries the high risk of poor outcomes. Identification of high-risk individuals by using prognostic evaluation was intended to do a closer follow up and more intensive to decreasing the morbidity and mortality rate of heart failure.To determine whether PREDICE score could predict mortality within 90 days in patients with heart failure, an observational cohort study in patients with heart failure who were hospitalized due to worsening chronic heart failure. Patients were in following-up for up to 90 days after initial evaluation with the primary endpoint is death.We found a difference of the significantstatistical between PREDICE score in survival and mortality group (p=0.001) of 84% (95% CI: 60.9% - 97.4%).In conclusion, PREDICE score has a good ability to predict mortality within 90 days in patients with heart failure.

  20. Finding-equal regression method and its application in predication of U resources

    International Nuclear Information System (INIS)

    Cao Huimo

    1995-03-01

    The commonly adopted deposit model method in mineral resources predication has two main part: one is model data that show up geological mineralization law for deposit, the other is statistics predication method that accords with characters of the data namely pretty regression method. This kind of regression method may be called finding-equal regression, which is made of the linear regression and distribution finding-equal method. Because distribution finding-equal method is a data pretreatment which accords with advanced mathematical precondition for the linear regression namely equal distribution theory, and this kind of data pretreatment is possible of realization. Therefore finding-equal regression not only can overcome nonlinear limitations, that are commonly occurred in traditional linear regression or other regression and always have no solution, but also can distinguish outliers and eliminate its weak influence, which would usually appeared when Robust regression possesses outlier in independent variables. Thus this newly finding-equal regression stands the best status in all kind of regression methods. Finally, two good examples of U resource quantitative predication are provided

  1. Maltose-binding protein effectively stabilizes the partially closed conformation of the ATP-binding cassette transporter MalFGK2

    KAUST Repository

    Weng, Jingwei; Gu, Shuo; Gao, Xin; Huang, Xuhui; Wang, Wenning

    2017-01-01

    Maltose transporter MalFGK2 is a type-I importer in the ATP-binding cassette (ABC) transporter superfamily. Upon the binding of its periplasmic binding protein, MalE, the ATPase activity of MalFGK2 can be greatly enhanced. Crystal structures of the MalFGK2-MalE-maltose complex in a so-called

  2. Maltose-binding protein effectively stabilizes the partially closed conformation of the ATP-binding cassette transporter MalFGK2

    KAUST Repository

    Weng, Jingwei

    2017-02-23

    Maltose transporter MalFGK2 is a type-I importer in the ATP-binding cassette (ABC) transporter superfamily. Upon the binding of its periplasmic binding protein, MalE, the ATPase activity of MalFGK2 can be greatly enhanced. Crystal structures of the MalFGK2-MalE-maltose complex in a so-called

  3. Mucin 1 (MUC1 is a novel partner for MAL2 in breast carcinoma cells

    Directory of Open Access Journals (Sweden)

    McGuckin Michael A

    2009-01-01

    Full Text Available Abstract Background The MAL2 gene, encoding a four-transmembrane protein of the MAL family, is amplified and overexpressed in breast and other cancers, yet the significance of this is unknown. MAL-like proteins have trafficking functions, but their molecular roles are largely obscure, partly due to a lack of known binding partners. Methods Yeast two-hybrid screening of a breast carcinoma cDNA expression library was performed using a full-length MAL2 bait, and subsequent deletion mapping experiments were performed. MAL2 interactions were confirmed by co-immunoprecipitation analyses and confocal microscopy was employed to compare protein sub-cellular distributions. Sucrose density gradient centrifugation of membranes extracted in cold Triton X-100 was employed to compare protein distributions between Triton X-100-soluble and -insoluble fractions. Results The tumor-associated protein mucin 1 (MUC1 was identified as a potential MAL2 partner, with MAL2/MUC1 interactions being confirmed in myc-tagged MAL2-expressing MCF-10A cells using co-immunoprecipitation assays. Deletion mapping experiments demonstrated a requirement for the first MAL2 transmembrane domain for MUC1 binding, whereas the MAL2 N-terminal domain was required to bind D52-like proteins. Confocal microscopy identified cytoplasmic co-localisation of MUC1 and MAL2 in breast cell lines, and centrifugation of cell lysates to equilibrium in sucrose density gradients demonstrated that MAL2 and MUC1 proteins were co-distributed between Triton X-100-soluble and -insoluble fractions. However co-immunoprecipitation analyses detected MAL2/MUC1 interactions in Triton X-100-soluble fractions only. Myc-MAL2 expression in MCF-10A cells was associated with both increased MUC1 detection within Triton X-100-soluble and -insoluble fractions, and increased MUC1 detection at the cell surface. Conclusion These results identify MUC1 as a novel MAL2 partner, and suggest a role for MAL2 in regulating MUC1

  4. Sequential Action of MalE and Maltose Allows Coupling ATP Hydrolysis to Translocation in the MalFGK2 Transporter.

    Science.gov (United States)

    Bao, Huan; Dalal, Kush; Cytrynbaum, Eric; Duong, Franck

    2015-10-16

    ATP-binding cassette (ABC) transporters have evolved an ATP-dependent alternating-access mechanism to transport substrates across membranes. Despite important progress, especially in their structural analysis, it is still unknown how the substrate stimulates ATP hydrolysis, the hallmark of ABC transporters. In this study, we measure the ATP turnover cycle of MalFGK2 in steady and pre-steady state conditions. We show that (i) the basal ATPase activity of MalFGK2 is very low because the cleavage of ATP is rate-limiting, (ii) the binding of open-state MalE to the transporter induces ATP cleavage but leaves release of Pi limiting, and (iii) the additional presence of maltose stimulates release of Pi, and therefore increases the overall ATP turnover cycle. We conclude that open-state MalE stabilizes MalFGK2 in the outward-facing conformation until maltose triggers return to the inward-facing state for substrate and Pi release. This concerted action explains why ATPase activity of MalFGK2 depends on maltose, and why MalE is essential for transport. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  5. Predicate Structures, Gesture, and Simultaneity in the Representation of Action in British Sign Language: Evidence From Deaf Children and Adults

    Science.gov (United States)

    Cormier, Kearsy

    2013-01-01

    British Sign Language (BSL) signers use a variety of structures, such as constructed action (CA), depicting constructions (DCs), or lexical verbs, to represent action and other verbal meanings. This study examines the use of these verbal predicate structures and their gestural counterparts, both separately and simultaneously, in narratives by deaf children with various levels of exposure to BSL (ages 5;1 to 7;5) and deaf adult native BSL signers. Results reveal that all groups used the same types of predicative structures, including children with minimal BSL exposure. However, adults used CA, DCs, and/or lexical signs simultaneously more frequently than children. These results suggest that simultaneous use of CA with lexical and depicting predicates is more complex than the use of these predicate structures alone and thus may take deaf children more time to master. PMID:23670881

  6. Historia de la voluntad y banalidad del mal

    Directory of Open Access Journals (Sweden)

    Prior Olmos, Ángel

    2010-04-01

    Full Text Available This article discusses the connections existing in The Life of the Mind between the theory of the banality of evil and the history of the will. It interprets Eichmann in Jerusalem as a work about bureaucratic evil, but above all as research concerning both moral and juridical responsibility. From the history of the will it highlights three different aspects that can be connected with the problem of responsibility: the ontology of contingency, the idea of individuality linked to the will and the capacity of transcendence and resistance that we see in the Duns Scotus’ theory, where liberty equals indifference. Finally, it suggests a link between the banality of evil and the ontology of good as these are present in “Some questions of moral philosophy” (1965-1966, the fight against Gnosticism and the defense of a relationship between morality and evil’s intelligibility.

    El artículo plantea las conexiones entre la tesis de la banalidad del mal y la historia de la voluntad presente en La vida del espíritu. Interpreta Eichmann en Jerusalén como una obra sobre el mal burocrático, pero sobre todo como estudio acerca de la responsabilidad, tanto jurídica como moral. De la historia de la voluntad resalta tres aspectos que pueden ser puestos en conexión con el problema de la responsabilidad: la ontología de la contingencia, la idea de individualidad vinculada a la voluntad y la capacidad de trascendencia y resistencia subyacentes en la teoría de Duns Escoto de la libertad como indiferencia. Por último, sugiere una vinculación entre la banalidad del mal y la ontología del bien desarrolladas en “Algunas cuestiones de filosofía moral”, de 1965-1966, la lucha contra el gnosticismo y la defensa de una relación entre moralidad e inteligibilidad del mal.

  7. El problema del mal y la violencia en Colombia

    Directory of Open Access Journals (Sweden)

    Victor Eligio Espinosa Galán

    2015-09-01

    Full Text Available La historia de la humanidad está marcada por conflictos de distinta naturaleza: religiosos, ideológicos, raciales, etc., expresados en guerras, ataques terroristas, masacres, entre muchas otras situaciones de crueldad que muestran maldad y sevicia ejercida sobre seres humanos. Ante estos acontecimientos que nos enfrentan a la pregunta: ¿qué es aquello que nos hace humanos?, parece, en un contexto como el colombiano, que se asiste a formas oficiales de una agencia de maldad como posibilidad de un ethos cultural que hace plausibles las acciones más perversas en una desoladora minimización de responsabilidad moral, necesaria para construcción de una sociedad justa y en paz. Este escrito es un esfuerzo por pensar el problema del mal en el contexto de la violencia en Colombia y dar cuenta de algunos aspectos de la reflexión filosófica sobre el mal, el sufrimiento y el sentido de la vida; se toma como contexto el conflicto armado en Colombia y las narraciones de sus protagonistas.

  8. PASBio: predicate-argument structures for event extraction in molecular biology

    Science.gov (United States)

    Wattarujeekrit, Tuangthong; Shah, Parantu K; Collier, Nigel

    2004-01-01

    Background The exploitation of information extraction (IE), a technology aiming to provide instances of structured representations from free-form text, has been rapidly growing within the molecular biology (MB) research community to keep track of the latest results reported in literature. IE systems have traditionally used shallow syntactic patterns for matching facts in sentences but such approaches appear inadequate to achieve high accuracy in MB event extraction due to complex sentence structure. A consensus in the IE community is emerging on the necessity for exploiting deeper knowledge structures such as through the relations between a verb and its arguments shown by predicate-argument structure (PAS). PAS is of interest as structures typically correspond to events of interest and their participating entities. For this to be realized within IE a key knowledge component is the definition of PAS frames. PAS frames for non-technical domains such as newswire are already being constructed in several projects such as PropBank, VerbNet, and FrameNet. Knowledge from PAS should enable more accurate applications in several areas where sentence understanding is required like machine translation and text summarization. In this article, we explore the need to adapt PAS for the MB domain and specify PAS frames to support IE, as well as outlining the major issues that require consideration in their construction. Results We introduce PASBio by extending a model based on PropBank to the MB domain. The hypothesis we explore is that PAS holds the key for understanding relationships describing the roles of genes and gene products in mediating their biological functions. We chose predicates describing gene expression, molecular interactions and signal transduction events with the aim of covering a number of research areas in MB. Analysis was performed on sentences containing a set of verbal predicates from MEDLINE and full text journals. Results confirm the necessity to analyze

  9. Logical Characterisation of Concept Transformations from Human into Machine relying on Predicate Logic

    DEFF Research Database (Denmark)

    Badie, Farshad

    2016-01-01

    Providing more human-like concept learning in machines has always been one of the most significant goals of machine learning paradigms and of human-machine interaction techniques. This article attempts to provide a logical specification of conceptual mappings from humans’ minds into machines......’ knowledge bases. I will focus on the representation of the mappings (transformations) relying on First-Order Predicate Logic. Additionally, the structure of concepts in the common ground between humans and machines will be analysed. It seems quite necessary to pay attention to the philosophy...

  10. Glucose and maltose metabolism in MIG1-disrupted and MAL-constitutive strains of Saccharomyces cerevisiae

    DEFF Research Database (Denmark)

    Klein, Christopher; Olsson, Lisbeth; Rønnow, B

    1997-01-01

    in a mixed glucose-maltose medium revealed that the MAL-constitutive strains were more alleviated than the single MIG1-disrupted transformant. While all transformants exhibited higher maximum specific growth rates (0.24-0.25 h(-1)) in glucose-maltose mixtures than the wild type strain (0.20 h(-1)), the MAL-constitutive...

  11. Characterization of different crystal forms of the alpha-glucosidase MalA from Sulfolobus solfataricus

    DEFF Research Database (Denmark)

    Ernst, Heidi Asschenfeldt; Willemoës, Martin; Lo Leggio, Leila

    2005-01-01

    MalA is an alpha-glucosidase from the hyperthermophilic archaeon Sulfolobus solfataricus. It belongs to glycoside hydrolase family 31, which includes several medically interesting alpha-glucosidases. MalA and its selenomethionine derivative have been overproduced in Escherichia coli...

  12. Effect of postharvest storage on the expression of the apple allergen Mal d 1

    NARCIS (Netherlands)

    Sancho, Ana I.; Foxall, Robert; Browne, Tom; dey, Rickmer; Zuidmeer, Laurian; Marzban, Gorji; Waldron, Keith W.; van Ree, Ronald; Hoffmann-Sommergruber, Karin; Laimer, Margit; Mills, E. N. Clare

    2006-01-01

    Consumption of fresh apples can cause allergy in susceptible individuals. A competitive enzyme-linked immunosorbent assay (ELISA) has been developed to determine Mal d 1 levels in apple pulp using a monoclonal antibody (BIP-1). The ELISA was able to rank ten cultivars according to their Mal d 1

  13. Epigenetic silencing of MAL, a putative tumor suppressor gene, can contribute to human epithelium cell carcinoma

    Directory of Open Access Journals (Sweden)

    Zhang Jun

    2010-11-01

    Full Text Available Abstract Background To identify new and useful candidate biomarkers in head and neck squamous cell carcinoma (HNSCC, we performed a genome-wide survey and found that Myelin and lymphocyte-associated protein (MAL was a gene that was markedly down-regulated in HNSCC. Hence, we investigated the mechanism of MAL silencing and the effects of MAL on the proliferation, invasion, and apoptotic potential in HNSCC. Results MAL was significantly down-regulated in 91.7% of HNSCC specimens at the mRNA level as compared with adjacent normal tissues (P = 0.0004. Moreover, the relative transcript levels of the MAL gene were remarkably decreased by five-fold in nine HNSCC cell lines as compared with normal head and neck epithelium cells. MAL gene expression was restored in 44%, 67%, and 89% in HNSCC cell lines treated with TSA, 5-Aza-dC, and TSA plus 5-Aza-dC, respectively. Furthermore, bisulfate-treated DNA sequencing demonstrated that the two CpG islands (that is, M1 and M2 located in MAL promoter region were completely methylated in the HNSCC cell lines (CpG methylated ratio was more than 90%, and only one CpG island (that is, M1 was partially methylated in HNSCC tissues (CpG methylated ratio between 20% and 90%. A significant reduction in cell proliferation and a change in the cell cycle profile were also observed in MAL transfectants. Matrigel assay demonstrated that the invasiveness of HNSCC cells significantly decreased. A significant increase in the population of apoptotic cells was observed in MAL transfected cells. The exogenous expression of the MAL gene suppressed malignant phenotypes, while the cell death induced by MAL gene transfer was a result of apoptosis as demonstrated by the induction of cleavage of the poly (that is, ADP-ribose polymerase. Additionally, tumor growth was suppressed in cells expressing MAL as compared with cells not expressing MAL. Conclusion Our data suggest that the epigenetic inactivation of MAL, as a candidate tumor

  14. Fernandez osteotomy of radio distal with mal united fracture

    International Nuclear Information System (INIS)

    Garcia Herrera, Alvaro; Bocanegra, Sergio; Suarez, Fabio

    2003-01-01

    We review prospectively our experience in the military hospital in Bogota, Colombia, with the opening-wedge osteotomy for the treatment of a mal united fracture of the distal end of the radius in fifty-six consecutive patients from 1990 to 2002. The indications for operation were pain predominantly in the radio-ulnar joint and functional limitation with grip strength loss. Preoperative radiographs revealed an average ulnar inclination of 14 degrees, an average ulnar variance of four millimeters, and increased dorsal tilt (colles deformity) that averaged 28 degrees. All patients had limited function. The average grip strength was a force of fifteen kilograms compared with a force of thirty-one kilograms in the contralateral hand. Postoperatively, all of the patients had substantial improvement in function, relief of pain and grip strength increased. The functional results were rated as very good in eleven patients, good in thirty-six, fair in nine

  15. [Clonage of the "malA" region of "Escherichia coli" K12: nucleotide sequence of the regulatory region and the promoters, identification and purification of the MalT-activator protein (author's transl)].

    Science.gov (United States)

    Raibaud, O; Débarbouillé, M; Cossart, P

    1982-01-01

    A 5,800-bp (base pair) HindIII-EcoRI DNA fragment containing malT, the positive regulator gene of the maltose regulon, and most of malP, the structural gene for maltodextrin phosphorylase, was cloned into pBR322. A sequence of 802 bp was established in a DNA segment containing the promotor for malPQ and the promoter for malT. A total of 611 bp separates the initiation codons for these two genes, which are transcribed in opposite directions. The malT product was identified as a 94,000 dalton polypeptide.

  16. Convex polyhedral abstractions, specialisation and property-based predicate splitting in Horn clause verification

    DEFF Research Database (Denmark)

    Kafle, Bishoksan; Gallagher, John Patrick

    2014-01-01

    We present an approach to constrained Horn clause (CHC) verification combining three techniques: abstract interpretation over a domain of convex polyhedra, specialisation of the constraints in CHCs using abstract interpretation of query-answer transformed clauses, and refinement by splitting...... in conjunction with specialisation for propagating constraints it can frequently solve challenging verification problems. This is a contribution in itself, but refinement is needed when it fails, and the question of how to refine convex polyhedral analyses has not been studied much. We present a refinement...... technique based on interpolants derived from a counterexample trace; these are used to drive a property-based specialisation that splits predicates, leading in turn to more precise convex polyhedral analyses. The process of specialisation, analysis and splitting can be repeated, in a manner similar...

  17. Estados de mal epiléptico na sindrome Delennox-Gastaut: aspectos terapeuticos

    Directory of Open Access Journals (Sweden)

    José Geraldo Speciali

    1977-09-01

    Full Text Available Foram descritas as condutas terapêuticas utilizadas nos estados de mal epiléptico, convulsivos e não convulsivos, observados em 14 pacientes com síndrome de Lennox-Gastaut. Verificou-se relação temporal entre aparecimento de estado de mal epiléptico e início de tratamento com clonazepam e difenilhidantoina; a retirada dessas medicações foi seguida pelo desaparecimento dos estados de mal. Indicou-se a possibilidade de tratamento dos estados de mal epiléptico modificando-se o esquema terapêutico administrado por via oral, reservando-se o tratamento parenteral para os estados com comprometimento progressivo da consciência e/ou dos distúrbios neurovegetativos.

  18. "Kevad uhkelt sammub mal kui jumalanna..." : [luuletused] / Ljubov Dergatshova ; tlk. Arvo Valton

    Index Scriptorium Estoniae

    Dergatshova, Ljubov

    2006-01-01

    Sisu: "Kevad uhkelt sammub mal kui jumalanna..." ; "Maga, pojake, maga mu päike..." ; "Mis kaunis õhtu! Lumi tahke..." ; "Raskel tunnil sirutab kes käe...". Luuletused paralleelselt ersa ja eesti keeles

  19. On Kripke-style semantics for the provability logic of Gödel’s proof predicate with quantifiers on proofs

    NARCIS (Netherlands)

    Yavorskiy, R.

    Kripke-style semantics is suggested for the provability logic with quantifiers on proofs corresponding to the standard Gödel proof predicate. It is proved that the set of valid formulas is decidable. The arithmetical completeness is still an open issue.

  20. Symmetric and Asymmetric Patterns of Attraction Errors in Producing Subject-Predicate Agreement in Hebrew: An Issue of Morphological Structure

    Science.gov (United States)

    Deutsch, Avital; Dank, Maya

    2011-01-01

    A common characteristic of subject-predicate agreement errors (usually termed attraction errors) in complex noun phrases is an asymmetrical pattern of error distribution, depending on the inflectional state of the nouns comprising the complex noun phrase. That is, attraction is most likely to occur when the head noun is the morphologically…

  1. BAYT AL-MAL AND ITS ROLE IN ECONOMIC DEVELOPMENT: A CONTEMPORARY STUDY

    Directory of Open Access Journals (Sweden)

    Md. Habibur RAHMAN

    2015-08-01

    Full Text Available Bayt al-Mal, known as the public treasury of Islamic state, was established by the Prophet-may peace be upon Him- and then it was further extended and expanded by Abu Bakr and Umar, who succeeded the Prophet as the Caliph of the Islamic state. It is the state treasury that keeps the sole authority to mobilize the funds of the state. This paper aims to study the potential role and contribution of Bayt al-Mal to economic development in the contemporary context. It will be a qualitative paper and the analytical and descriptive method will be applied. Historically Bayt al-Mal played a great role in the distribution and redistribution of funds. It performed the function that is similar to the function of the ministry of finance at present. It also carried out the jobs of central bank in terms of monitoring, issuing currencies, controlling credits and so forth. Through discussing its sources and expenditures the paper posits that the role of Bayt al-Mal can be revived and accelerated by, for example, providing small-medium funds, managing Zakah and awqaf, channeling the funds, issuing various financial instruments and so forth. Bayt al-Mal could have a significant role in the eradication of poverty from the state. The paper concludes that with the rapid growth of Islamic finance, the Bayt al-Mal can be utilized in parallel in order to have a robust economic development.

  2. Sobre a psicogênese do "mal de engasgo"

    Directory of Open Access Journals (Sweden)

    Durval Marcondes

    1947-06-01

    Full Text Available O A. ressalta o aspecto psicológico da etiologia do cardiospasmo ou mal de engasgo, assunto até agora não abordado nos meios científicos brasileiros. Sem pretender afastar outros elementos causais que tenham sido, porventura, verificados e que poderão, talvez, agir concomitantemente, o A. é de opinião que o mal de engasgo é um disturbio funcional condicionado psìquicamente, cujas conseqüências se tornam irreversíveis depois de certo tempo. As conclusões apresentadas baseiam-se no material fornecido por pacientes em tratamento psicanalítico que apresentam fenômenos disfágicos, e por vários casos das clínicas de orientação infantil entre cujos problemas se incluem, além da dificuldade de engulir, a anorexia e a bulimia. Com respeito às atividades emocionais típicas que formam o substrato psicológico do mal de engasgo, o ponto fundamental está em que êste representa um compromisso, expresso ao nível oral, entre tendências passivo-receptivas e ativo-expulsivas. A essa situação psíquica correspondem condições de ambiente, atuais ou pretéritas, que, de modo contraditório, favorecem uma atitude de dependência infantil, ao mesmo tempo que acarretam repetidas frustrações. Trata-se, em geral, de mães dominadoras que, enquanto superprotegem a criança, agem para com ela com demasiado rigor. A superproteção centraliza-se sobretudo no que se refere aos alimentos, que se investem, assim, de grande significado emocional. O A. apresenta o resumo de uma observação clínica que apoia seu ponto de vista. Também a anorexia e a bulimia, em seu substrato psicodinâmico, estão relacionadas com o problema do apego e da emancipação e giram em torno da pessoa da mãe e da função alimentar. A solução do conflito faz-se, porém, num dos casos, pela rejeição do alimento e, noutro, pela avidez. O mal de engasgo constitui o meio têrmo entre os dois extremos. Existem, igualmente, nas neuroses gástricas e em sua conseq

  3. Sobre el mal radical. Ensayo de la heterodoxia kantiana

    Directory of Open Access Journals (Sweden)

    Gómez Caffarena, José

    2004-06-01

    Full Text Available The kantian theory of a «radical evil inhabiting human nature» contrasts with a general anthropological optimistic tenor perceptible in kantian philosophy. It meant a significant turning point in the often too superficial optimistic trends of the Enlightenment. Hut its literal sense (appealing to an act of pre-individual freedom has an obvious difficulty. The present paper proposes an heterodox interpretation, which would avoid the difficulty, although so losing part of the tempting enigmatic reach of the kantian proposal.

    La teoría del «mal radical en la naturaleza humana», expuesta por Kant en La religión dentro de los límites de la mera razón, hace contraste con el optimismo antropológico que empapa el Criticismo. Constituyó, sin duda, una importante denuncia frente a la banalidad de muchos optimismos ilustrados. Pero su letra (acto de libertad pre-individual tiene una obvia dificultad. El artículo propone una reinterpretación que la evitaría, aunque desdramatizando un tanto el tentador alcance enigmático de la propuesta kantiana.

  4. Assessment of allelic diversity in intron-containing Mal d 1 genes and their association to apple allergenicity

    Directory of Open Access Journals (Sweden)

    Bolhaar Suzanne THP

    2008-11-01

    Full Text Available Abstract Background Mal d 1 is a major apple allergen causing food allergic symptoms of the oral allergy syndrome (OAS in birch-pollen sensitised patients. The Mal d 1 gene family is known to have at least 7 intron-containing and 11 intronless members that have been mapped in clusters on three linkage groups. In this study, the allelic diversity of the seven intron-containing Mal d 1 genes was assessed among a set of apple cultivars by sequencing or indirectly through pedigree genotyping. Protein variant constitutions were subsequently compared with Skin Prick Test (SPT responses to study the association of deduced protein variants with allergenicity in a set of 14 cultivars. Results From the seven intron-containing Mal d 1 genes investigated, Mal d 1.01 and Mal d 1.02 were highly conserved, as nine out of ten cultivars coded for the same protein variant, while only one cultivar coded for a second variant. Mal d 1.04, Mal d 1.05 and Mal d 1.06 A, B and C were more variable, coding for three to six different protein variants. Comparison of Mal d 1 allelic composition between the high-allergenic cultivar Golden Delicious and the low-allergenic cultivars Santana and Priscilla, which are linked in pedigree, showed an association between the protein variants coded by the Mal d 1.04 and -1.06A genes (both located on linkage group 16 with allergenicity. This association was confirmed in 10 other cultivars. In addition, Mal d 1.06A allele dosage effects associated with the degree of allergenicity based on prick to prick testing. Conversely, no associations were observed for the protein variants coded by the Mal d 1.01 (on linkage group 13, -1.02, -1.06B, -1.06C genes (all on linkage group 16, nor by the Mal d 1.05 gene (on linkage group 6. Conclusion Protein variant compositions of Mal d 1.04 and -1.06A and, in case of Mal d 1.06A, allele doses are associated with the differences in allergenicity among fourteen apple cultivars. This information

  5. An Insider Threat Neutralization Mitigation Model Predicated On Cognitive Dissonance (ITNMCD

    Directory of Open Access Journals (Sweden)

    Keshnee Padayachee

    2015-07-01

    Full Text Available The insider threat concern is a complex issue, as the problem domain intersects the social, technical and socio-technical dimensions. Consequently, counteracting the insider threat involves influencing the insider’s perceptions and behaviour in order to ensure compliance. When an individual’s actions and beliefs are incongruent, this induces a phenomenon known as cognitive dissonance. In order to reduce this dissonance, individuals are self-motivated either to change their behaviours or beliefs, or to rationalize their behaviour. Neutralization is a technique used by criminals to rationalize maleficence. In terms of the insider threat, it has been proposed that if the justifications for committing an offence are eliminated, then the insider is less likely to commit the offence. This process is known as neutralization mitigation. The research reported on here proposes that inducing cognitive dissonance may be a means of mitigating the neutralizations that the insider may use to justify maleficence. To integrate these concepts into a pragmatic implementable solution the Insider Threat Neutralization Mitigation model predicated on Cognitive Dissonance (ITNMCD is proposed. A proof-of-concept was developed and the model concept was evaluated using the design science method.

  6. Predication of skin temperature and thermal comfort under two-way transient environments.

    Science.gov (United States)

    Zhou, Xin; Xiong, Jing; Lian, Zhiwei

    2017-12-01

    In this study, three transient environmental conditions consisting of one high-temperature phase within two low-temperature phases were developed, thus creating a temperature rise followed by a temperature fall. Twenty-four subjects (including 12 males and 12 females) were recruited and they underwent all three test scenarios. Skin temperature on seven body parts were measured during the whole period of the experiment. Besides, thermal sensation was investigated at specific moments by questionnaires. Thermal sensation models including PMV model, Fiala model and the Chinese model were applied to predict subjects' thermal sensation with comparisons carried out among them. Results show that most predicated thermal sensation by Chinese model lies within the range of 0.5 scale of the observed sensation vote, and it agrees best with the observed thermal sensation in transient thermal environment than PMV and Fiala model. Further studies should be carried out to improve performance of Chinese model for temperature alterations between "very hot" to "hot" environment, for prediction error in the temperature-fall situation of C5 (37-32°C) was over 0.5 scale. Copyright © 2017 Elsevier Ltd. All rights reserved.

  7. Integrated analyzing method for the progress event based on subjects and predicates in events

    International Nuclear Information System (INIS)

    Minowa, Hirotsugu; Munesawa, Yoshiomi

    2014-01-01

    It is expected to make use of the knowledge that was extracted by analyzing the mistakes of the past to prevent recurrence of accidents. Currently main analytic style is an analytic style that experts decipher deeply the accident cases, but cross-analysis has come to an end with extracting the common factors in the accident cases. We propose an integrated analyzing method for progress events to analyze among accidents in this study. Our method realized the integration of many accident cases by the integration connecting the common keyword called as 'Subject' or 'Predicate' that are extracted from each progress event in accident cases or near-miss cases. Our method can analyze and visualize the partial risk identification and the frequency to cause accidents and the risk assessment from the data integrated accident cases. The result of applying our method to PEC-SAFER accident cases identified 8 hazardous factors which can be caused from tank again, and visualized the high frequent factors that the first factor was damage of tank 26% and the second factor was the corrosion 21%, and visualized the high risks that the first risk was the damage 3.3 x 10 -2 [risk rank / year] and the second risk was the destroy 2.5 x 10 -2 [risk rank / year]. (author)

  8. A brief history of typical absence seizures - Petit mal revisited.

    Science.gov (United States)

    Brigo, Francesco; Trinka, Eugen; Lattanzi, Simona; Bragazzi, Nicola Luigi; Nardone, Raffaele; Martini, Mariano

    2018-03-01

    In this article, we have traced back the history of typical absence seizures, from their initial clinical description to the more recent nosological position. The first description of absence seizures was made by Poupart in 1705 and Tissot in 1770. In 1824, Calmeil introduced the term "absences", and in 1838, Esquirol for the first time used the term petit mal. Reynolds instead used the term "epilepsia mitior" (milder epilepsy) and provided a comprehensive description of absence seizures (1861). In 1854, Delasiauve ranked absences as the seizure type with lower severity and introduced the concept of idiopathic epilepsy. Otto Binswanger (1899) discussed the role of cortex in the pathophysiology of "abortive seizures", whereas William Gowers (1901) emphasized the importance of a detailed clinical history to identify nonmotor seizures or very mild motor phenomena which otherwise may go unnoticed or considered not epileptic. At the beginning of the 20th Century, the term pyknolepsy was introduced, but initially was not universally considered as a type of epilepsy; it was definitely recognized as an epileptic entity only in 1945, based on electroencephalogram (EEG) recordings. Hans Berger, the inventor of the EEG, made also the first EEG recording of an atypical absence (his results were published only in 1933), whereas the characteristic EEG pattern was reported by neurophysiologists of the Harvard Medical School in 1935. The discovery of EEG made it also possible to differentiate absence seizures from so called "psychomotor" seizures occurring in temporal lobe epilepsy. Penfield and Jasper (1938) considered absences as expression of "centrencephalic epilepsy". Typical absences seizures are now classified by the International League Against Epilepsy among generalized nonmotor (absence) seizures. Copyright © 2018 Elsevier Inc. All rights reserved.

  9. Metabolic and functional connectivity changes in mal de debarquement syndrome.

    Directory of Open Access Journals (Sweden)

    Yoon-Hee Cha

    Full Text Available Individuals with mal de debarquement syndrome (MdDS experience a chronic illusion of self-motion triggered by prolonged exposure to passive motion, such as from sea or air travel. The experience is one of rocking dizziness similar to when the individual was originally on the motion trigger such as a boat or airplane. MdDS represents a prolonged version of a normal phenomenon familiar to most individuals but which persists for months or years in others. It represents a natural example of the neuroplasticity of motion adaptation. However, the localization of where that motion adaptation occurs is unknown. Our goal was to localize metabolic and functional connectivity changes associated with persistent MdDS.Twenty subjects with MdDS lasting a median duration of 17.5 months were compared to 20 normal controls with (18F FDG PET and resting state fMRI. Resting state metabolism and functional connectivity were calculated using age, grey matter volume, and mood and anxiety scores as nuisance covariates.MdDS subjects showed increased metabolism in the left entorhinal cortex and amygdala (z>3.3. Areas of relative hypometabolism included the left superior medial gyrus, left middle frontal gyrus, right amygdala, right insula, and clusters in the left superior, middle, and inferior temporal gyri. MdDS subjects showed increased connectivity between the entorhinal cortex/amygdala cluster and posterior visual and vestibular processing areas including middle temporal gyrus, motion sensitive area MT/V5, superior parietal lobule, and primary visual cortex, while showing decreased connectivity to multiple prefrontal areas.These data show an association between resting state metabolic activity and functional connectivity between the entorhinal cortex and amygdala in a human disorder of abnormal motion perception. We propose a model for how these biological substrates can allow a limited period of motion exposure to lead to chronic perceptions of self-motion.

  10. Contribución al conocimiento de los malófagos (Phthiraptera, Amblycera, Ischnocera de aves peruanas. Parte 1

    Directory of Open Access Journals (Sweden)

    Luis A. Gomez-Puerta

    2015-12-01

    Full Text Available En el presente trabajo se reporta nueve especies de malófagos colectados de aves peruanas. Dos malófagos Amblycera: Heteromenopon laticapitis y Menacanthus pici, así como siete malófagos Ischnocera: Alcedoffula theresae, Brueelia brunneinucha, Chelopistes meleagridis, Columbicola columbae, Paragoniocotes aratingae, Penenirmus jungens y Saemundssonia (Saemundssonia lari, fueron determinados mediante el diagnóstico morfológico. Se realiza una breve descripción de cada malófago, así como la discusión de sus hospederos y distribución.

  11. Interaction of PLP with GFP-MAL2 in the human oligodendroglial cell line HOG.

    Directory of Open Access Journals (Sweden)

    Raquel Bello-Morales

    Full Text Available The velocity of the nerve impulse conduction of vertebrates relies on the myelin sheath, an electrically insulating layer that surrounds axons in both the central and peripheral nervous systems, enabling saltatory conduction of the action potential. Oligodendrocytes are the myelin-producing glial cells in the central nervous system. A deeper understanding of the molecular basis of myelination and, specifically, of the transport of myelin proteins, will contribute to the search of the aetiology of many dysmyelinating and demyelinating diseases, including multiple sclerosis. Recent investigations suggest that proteolipid protein (PLP, the major myelin protein, could reach myelin sheath by an indirect transport pathway, that is, a transcytotic route via the plasma membrane of the cell body. If PLP transport relies on a transcytotic process, it is reasonable to consider that this myelin protein could be associated with MAL2, a raft protein essential for transcytosis. In this study, carried out with the human oligodendrocytic cell line HOG, we show that PLP colocalized with green fluorescent protein (GFP-MAL2 after internalization from the plasma membrane. In addition, both immunoprecipitation and immunofluorescence assays, indicated the existence of an interaction between GFP-MAL2 and PLP. Finally, ultrastructural studies demonstrated colocalization of GFP-MAL2 and PLP in vesicles and tubulovesicular structures. Taken together, these results prove for the first time the interaction of PLP and MAL2 in oligodendrocytic cells, supporting the transcytotic model of PLP transport previously suggested.

  12. Maltase protein of Ogataea (Hansenula) polymorpha is a counterpart to resurrected ancestor protein ancMALS of yeast maltases and isomaltases

    DEFF Research Database (Denmark)

    Viigand, Katrin; Visnapuu, Triinu; Mardo, Karin

    2016-01-01

    and mutation of the genes. We studied substrate specificity of the maltase protein MAL1 from an earlier diverged yeast, Ogataea polymorpha (Op), in the light of this hypothesis. MAL1 has extended substrate specificity and its properties are strikingly similar to those of resurrected ancMALS. Moreover, amino......, indicating the power of the method to predict substrate binding. Deletion of either the maltase (MAL1) or α-glucoside permease (MAL2) gene in Op abolished the growth of yeast on MAL1 substrates, confirming the requirement of both proteins for usage of these sugars....

  13. [Clinical applications of dosing algorithm in the predication of warfarin maintenance dose].

    Science.gov (United States)

    Huang, Sheng-wen; Xiang, Dao-kang; An, Bang-quan; Li, Gui-fang; Huang, Ling; Wu, Hai-li

    2011-12-27

    To evaluate the feasibility of clinical application for genetic based dosing algorithm in the predication of warfarin maintenance dose in Chinese population. The clinical data were collected and blood samples harvested from a total of 126 patients undergoing heart valve replacement. The genotypes of VKORC1 and CYP2C9 were determined by melting curve analysis after PCR. They were divided randomly into the study and control groups. In the study group, the first three doses of warfarin were prescribed according to the predicted warfarin maintenance dose while warfarin was initiated at 2.5 mg/d in the control group. The warfarin doses were adjusted according to the measured international normalized ratio (INR) values. And all subjects were followed for 50 days after an initiation of warfarin therapy. At the end of a 50-day follow-up period, the proportions of the patients on a stable dose were 82.4% (42/51) and 62.5% (30/48) for the study and control groups respectively. The mean durations of reaching a stable dose of warfarin were (27.5 ± 1.8) and (34.7 ± 1.8) days and the median durations were (24.0 ± 1.7) and (33.0 ± 4.5) days in the study and control groups respectively. Significant differences existed in the durations of reaching a stable dose between the two groups (P = 0.012). Compared with the control group, the hazard ratio (HR) for the duration of reaching a stable dose was 1.786 in the study group (95%CI 1.088 - 2.875, P = 0.026). The predicted dosing algorithm incorporating genetic and non-genetic factors may shorten the duration of achieving efficiently a stable dose of warfarin. And the present study validates the feasibility of its clinical application.

  14. Social, societal, and economic burden of mal de debarquement syndrome.

    Science.gov (United States)

    Macke, Allison; LePorte, Andrew; Clark, Brian C

    2012-07-01

    Mal de debarquement syndrome (MdDS) is a disorder of phantom perception of self-motion of unknown cause. The purpose of this work was to describe the quality of life (QOL) of patients with MdDS and to estimate the economic costs associated with this disorder. A modified version of a QOL survey used for another neurological disease (multiple sclerosis; MSQOL-54) was used to assess the impact of MdDS on QOL in 101 patients. The estimated economic costs were based on self-reported direct and indirect costs of individuals living in the United States using Medicare reimbursement payment rates for 2011 in 79 patients. Patients with MdDS reported a poor overall QOL as indicated by a mean composite QOL score of 59.26 ± 1.89 (out of 100). The subcategories having the lowest QOL rating were role limitations due to physical problems (18.32 ± 3.20), energy (34.24 ± 1.47), and emotional problems (36.30 ± 4.00). The overall physical health composite score including balance was 49.40 ± 1.69, and the overall mental health composite score was 52.40 ± 1.83. The cost to obtain a diagnosis was $2,997 ± 337, which included requiring an average of 19 physician visits per patient. The direct cost of MdDS medical care was $826 ± 140 per patient per year, which mainly included diagnostic imaging and physician visits. The indirect costs (i.e., lost wages) were $9,781 ± 2,347 per patient per year. Among 65 patients who were gainfully employed when they acquired MdDS, the indirect costs were $11,888 ± 2,786 per patient per year. Thus, the total annual cost of the disorder ranged from $11,493 ± 2,341 to $13,561 ± 2,778 per patient per year depending on employment status prior to developing MdDS. MdDS negatively and dramatically impacts QOL, and also imposes a substantial economic burden on MdDS patients. These findings underscore the need for further basic and clinical research on MdDS.

  15. Estado de mal epiléptico en pediatría

    Directory of Open Access Journals (Sweden)

    Jorge Malagón Valdez

    2013-09-01

    Full Text Available El estado de mal epiléptico es una emergencia médica en la cual se presentan crisis epilépticas por 30 minutos o más de actividad continua, o bien dos o más crisis consecutivas sin recuperación completa de la conciencia entre las mismas. Actualmente se considera que una crisis epiléptica convulsiva o no, que dure más de 5 minuto se deberá considerar un estado de mal epiléptico. Se han utilizado diversos fármacos para el tratamiento de esta patología y sus secuelas. Hay un consenso generalizado en que se debe realizar un manejo agresivo para disminuir su morbi-mortalidad, sin olvidarse que la causa del estado de mal es importante para su manejo, control y sus secuelas.

  16. La seducción del mal en Estrella Distante de Roberto Bolaño

    OpenAIRE

    Montes, Cristian

    2013-01-01

    En el presente artículo se trabajará en torno a la novela Estrella distante de Roberto Bolaño. La intención del análisis será demostrar cómo se expresa y opera la seducción del mal al interior de la representación y proponer cuáles son las formas en que el mal encarna en una figura representativa de la dictadura militar chilena.

  17. Rising Mal-Employment and the Great Recession: The Growing Disconnection between Recent College Graduates and the College Labor Market

    Science.gov (United States)

    Fogg, Neeta P.; Harrington, Paul E.

    2011-01-01

    This article looks at the phenomenon of mal-employment among college graduates in the United States, beginning with an overview of labor-market trends and the effects of the Great Recession on the job-market experiences of young people, including recent college graduates. It then defines "mal-employment" and examines its incidence over…

  18. Maturity and storage influence on the apple (Malus domestica) allergen Mal d 3, a nonspecific lipid transfer protein

    NARCIS (Netherlands)

    Sancho, Ana I.; Foxall, Robert; Rigby, Neil M.; Browne, Thomas; Zuidmeer, Laurian; van Ree, Ronald; Waldron, Keith W.; Mills, E. N. Clare

    2006-01-01

    Consumption of apples can provoke severe allergic reactions, in susceptible individuals, due to the presence of the allergen Mal d 3, a nonspecific lipid transfer protein, found largely in the fruit skin. Levels of Mal d 3 were determined in peel as a function of apple cultivar, position of the

  19. [Heinike Heinsoo. Mā ja pūd lēväd, meid eb lē : the subject and the predicate in Votic] / Johanna Laakso

    Index Scriptorium Estoniae

    Laakso, Johanna, 1962-

    2012-01-01

    Arvustus: Heinike Heinsoo. Mā ja pūd lēväd, meid eb lē : the subject and the predicate in Votic. Tallinn : Teaduste Akadeemia Kirjastus, 2010. (Linguistica Uralica. Supplementary series ; vol. 4)

  20. LHV predication models and LHV effect on the performance of CI engine running with biodiesel blends

    International Nuclear Information System (INIS)

    Tesfa, B.; Gu, F.; Mishra, R.; Ball, A.D.

    2013-01-01

    Highlights: • Lower heating values of neat biodiesel and its blends were measured experimentally. • Lower heating value prediction models were developed based on the density and viscosity values of the fuel. • The predication models were validated by measured values and previous models. • The prediction models were used to predict the lower heating value of 24 biodiesel feedstock types produced globally. • The effects of lower heating vale on brake specific fuel consumption and thermal efficiency were investigated. - Abstract: The heating value of fuel is one of its most important physical properties, and is used for the design and numerical simulation of combustion processes within internal combustion (IC) engines. Recently, there has been a significant increase in the use of dual fuel and blended fuels in compression ignition (CI) engines. Most of the blended fuels include biodiesel as one of the constituents and hence the objective of this study is to investigate the effect of biodiesel content to lower heating value (LHV) and to develop new LHV prediction models that correlate the LHV with biodiesel fraction, density and viscosity. Furthermore, this study also investigated the effects of the LHV on CI engines performance parameters experimentally. To achieve the above mentioned objectives density, viscosity and LHV of rapeseed oil biodiesel, corn oil biodiesel and waste oil biodiesel at different blend fraction values (B0, B5, B10, B20, B50, B75, and B100, where ‘B5’ denotes a blend of 5% biodiesel and 95% mineral diesel, etc.) were measured as per EN ISO 3675:1998, EN ISO 3104:1996 and DIN 51900 standards. The engine experimental work was conducted on a four-cylinder, four-stroke, direct injection (DI) and turbocharged diesel engine by using rapeseed oil and normal diesel blends. Based on the experimental results, models were developed which have the capability to predict the LHV corresponding to different fractions, densities and viscosities of

  1. Le mal de Pott: à propos de 82 cas

    Directory of Open Access Journals (Sweden)

    Badr Fedoul

    2011-03-01

    Full Text Available Nous rapportant dans cette étude, les résultats de l’expérience du service de neurochirurgie du CHU Hassan II de Fès dans la prise en charge du mal de pott dans la région de Fès. Il s’agit d’une étude rétrospective de quatre-vingt-deux cas; étalée sur une période de cinq ans (janvier 2002 au décembre 2006. L’objectif de ce travail était d’illustrer les différents aspects épidémiologiques, diagnostiques et thérapeutiques de la localisation vertébrale de la tuberculose dans notre pratique. L'âge moyen de nos patients était de 43,1 ans, avec une légère prédominance féminine (53,82%. La durée d'évolution de la maladie était longue (dix mois en moyenne; ceci est expliquée par la symptomatologie initiale insidieuse faite de rachialgies (98,78% et une admission des patients au stade de complications neurologiques (41,46%. La radiographie standard était réalisée chez tous nos patients, et complétée par la TDM dans 86.58% des cas ce qui a permis de déceler la prédominance de l'atteinte dorsale et lombaire. L'IRM est l'examen de choix, elle était demandée chez tous les malades déficitaires (37,8%.Tous nos patients ont bénéficié d'un traitement antibacillaire associé à une immobilisation du foyer pottique. Une décompression par voie antérieure était réalisée chez 29 patients (35,36 %; alors que la laminectomie n'était pratiquée que chez 5 patients (6.09 %, tandis que l'évacuation de l'abcès de psoas était réalisée chez 25 patients (30,48 %. Le diagnostic de certitude histologique était posé dans 51 cas (62,19%. Les meilleurs résultats étaient obtenus chez les malades opérés par voie antérieure, 26 cas (89,65% de récupération totale et 3 cas (10,34% partielle. L'évolution vers la consolidation et la fusion vertébrale était la règle chez tous nos malades et ceci au bout de 4 à 18 mois après le traitement.

  2. Pengaruh Unsur Alam terhadap Minat Berkunjung Kembali di Mal

    Directory of Open Access Journals (Sweden)

    Riza Septriani Dewi

    2016-12-01

    Full Text Available Pusat perbelanjaan yang berkonsep alam dianggap lebih diminati pengunjung. Penelitian ini mengkaji tentang pengaruh unsur-unsur alam terhadap minat konsumen untuk berkunjung kembali. Variabel yang akan dikaji terdiri dari variabel bebas, yaitu air (diam-bergerak dan vegetasi (tanaman rendah-tanaman tinggi, dan variabel terikat, yaitu persepsi alam dan sikap berkunjung kembali. Penelitian ini menggunakan metode eksperimen stimulus-respon melalui pendekatan kuantitatif dengan prinsip between-subject factorial design. Simulasi gambar digital dari interior pusat perbelanjaan pada 4 kondisi sebagai kombinasi variabel tersebut di atas digunakan sebagai stimulus percobaan, di mana 4 kelompok responden, masing-masing 20 orang, akan menilai stimulus eksperimen dalam kondisi berbeda, atas dasar persepsi alam dan sikap berkunjung kembali. Data eksperimen dihitung dan dianalisa dengan statistik one-way ANOVA. Efek kombinasi variabel air bergerak dan tanaman tinggi ternyata tidak memberikan pengaruh yang signifikan terhadap persepsi alam responden. Efek kombinasi variabel air diam dengan tanaman tinggi tidak memberikan pengaruh yang signifikan terhadap minat responden untuk berkunjung kembali. Namun, efek kombinasi variabel air mengalir dengan tanaman rendah cenderung lebih mengundang persepsi alam yang baik dan minat berkunjung kembali. Hasil eksperimen ini diharapkan dapat menjadi rekomendasi bagi perkembangan ilmu desain dan sebagai salah satu referensi bagi desainer dan pengembang.Kata Kunci: mal; minat berkunjung; persepsi alam; perilaku konsumen.Effects of Natural Elements on Interest to Revisit a MallShopping malls with a natural concept are more attractive to visitors. This study examined the influence of natural interior design elements on client interest to revisit a mall. The assessed elements consisted of independent variables, namely water (still-standing/flowing and vegetation (ground plants/potted plants, and dependent variables, namely nature

  3. MAL Is a Regulator of the Recruitment of Myelin Protein PLP to Membrane Microdomains

    NARCIS (Netherlands)

    Bijlard, Marjolein; de Jonge, Jenny C.; Klunder, Bert; Nomden, Anita; Hoekstra, Dick; Baron, Wia

    2016-01-01

    In oligodendrocytes (OLGs), an indirect, transcytotic pathway is mediating transport of de novo synthesized PLP, a major myelin specific protein, from the apical-like plasma membrane to the specialized basolateral-like myelin membrane to prevent its premature compaction. MAL is a well-known

  4. Synthesis, crystal structure and magnetic properties of [Cu(mal)(abpt ...

    African Journals Online (AJOL)

    Complex 1 consist of a neutral mononuclear [Cu(mal)(abpt)(H2O)] unit and water molecule of crystallization in a distorted square pyramidal coordination sphere, while complex 2 is viewed as being made up of [Cu(sq)(abpt)2] units with the squarato ligand bridging the two copper(II) cations. Variable temperature magnetic ...

  5. Preparation of MAl O : Eu2+, Sm3+ (M = Ca, Sr, Ba) Phosphors by ...

    African Journals Online (AJOL)

    NJD

    2007-10-15

    Oct 15, 2007 ... clearly show that most peaks are assigned to those of the MAl2O4 structure. Moreover, their structures change with change of M. Samples A and B exhibit monoclinic crystal systems and sample. C a hexagonal structure. The doping Eu2+ and co-doping Sm3+ have very little influence on the structure of the ...

  6. Mal de Meleda: A Report of Two Cases In One Family

    Directory of Open Access Journals (Sweden)

    M.Kantor

    2006-08-01

    Full Text Available Mal de Meleda is a rare autosomal recessive skin disorder, characterized by transgressive palmoplantar keratoderma, lichenoid skin lesions, perioral erythema, brachydactyly and nail abnormalities. We are reporting two cases of a clinically typical disease in a family. No consanguineous relationship between the parents was known and cases could not be detected in three generations of the patient's family.

  7. Preparation of MAl 2 O 4 : Eu 2+ , Sm 3+ (M = Ca, Sr, Ba) Phosphors ...

    African Journals Online (AJOL)

    A series of MAl2O4: Eu2+, Sm3+ (M = Ca, Sr, Ba) phosphors was prepared by the combustion method, and the influence of these alkaline earth metals on the structure and luminescent performances for these phosphors was investigated. A relationship was established between their composition, crystallization capacity and ...

  8. Reminių lietuvių kalbos pagrindinių sakinio dalių perteikimas norvegų kalboje. Norwegian Equivalents to Lithuanian Rhemic Subject and Predicate

    Directory of Open Access Journals (Sweden)

    Aurelija Griškevičienė

    2008-01-01

    Full Text Available In Norwegian, like in other analytical languages, the distribution of information in terms of Functional Sentence Perspective (FSP is heavily constrained by the grammatically defined word order, whereas the main means of expression of FSP in written Lithuanian is the word order, which is grammatically unrestricted thus enabling to convey the new information by any sentence part. The aim of this article is to summarise and classify expressions of Norwegian equivalents to the rhemic subject and predicate in the Lithuanian language. The analysis resorts for illustrations to the short story “Gyvenimas po klevu” by Granauskas and its translation into Norwegian.The analysis shows, one of the best ways to shift the rhemic from the usual position at the begin­ning of a sentence in the Norwegian language is by applying the passive voice. The subject can equally be made rhemic by the cleft, presentative construction, the reduplication of a sentence part. The subject rhemisation can happen by replacing it with other sentence parts of the same meaning. To retain the rhemic subject in translation, not only can a word order be reshuffled, but even an extra sentence added to convey new information.In Norwegian, the predicate has a strictly defined second position. Therefore, the rhemic predicate is impossible to indicate by a word order. In Norwegian sentences where new information is presented through the predicate, the position of the predicate is considered rhemic, and no other means to express the rhemic predicated are employed. In translation, the rhemic predicate can be expressed through the nominalization, which facilitates the needed shift. As the empiric material demonstrates, the predicate replacement by any other sentence part is the most frequent way for the rhemisation of the predicate. It is also possible to make verb-for-verb replacement. In certain cases, extra themic elements, helping to shift the focus predicate.The use of lexical means

  9. Combining loop unrolling strategies and code predication to reduce the worst-case execution time of real-time software

    Directory of Open Access Journals (Sweden)

    Andreu Carminati

    2017-07-01

    Full Text Available Worst-case execution time (WCET is a parameter necessary to guarantee timing constraints on real-time systems. The higher the worst-case execution time of tasks, the higher will be the resource demand for the associated system. The goal of this paper is to propose a different way to perform loop unrolling on data-dependent loops using code predication targeting WCET reduction, because existing techniques only consider loops with fixed execution counts. We also combine our technique with existing unrolling approaches. Results showed that this combination can produce aggressive WCET reductions when compared with the original code.

  10. High temperature increases the masculinization rate of the all-female (XX) rainbow trout "Mal" population.

    Science.gov (United States)

    Valdivia, Karina; Jouanno, Elodie; Volff, Jean-Nicolas; Galiana-Arnoux, Delphine; Guyomard, René; Helary, Louise; Mourot, Brigitte; Fostier, Alexis; Quillet, Edwige; Guiguen, Yann

    2014-01-01

    Salmonids are generally considered to have a robust genetic sex determination system with a simple male heterogamety (XX/XY). However, spontaneous masculinization of XX females has been found in a rainbow trout population of gynogenetic doubled haploid individuals. The analysis of this masculinization phenotype transmission supported the hypothesis of the involvement of a recessive mutation (termed mal). As temperature effect on sex differentiation has been reported in some salmonid species, in this study we investigated in detail the potential implication of temperature on masculinization in this XX mal-carrying population. Seven families issued from XX mal-carrying parents were exposed from the time of hatching to different rearing water temperatures ((8, 12 and 18°C), and the resulting sex-ratios were confirmed by histological analysis of both gonads. Our results demonstrate that masculinization rates are strongly increased (up to nearly two fold) at the highest temperature treatment (18°C). Interestingly, we also found clear differences between temperatures on the masculinization of the left versus the right gonads with the right gonad consistently more often masculinized than the left one at lower temperatures (8 and 12°C). However, the masculinization rate is also strongly dependent on the genetic background of the XX mal-carrying families. Thus, masculinization in XX mal-carrying rainbow trout is potentially triggered by an interaction between the temperature treatment and a complex genetic background potentially involving some part of the genetic sex differentiation regulatory cascade along with some minor sex-influencing loci. These results indicate that despite its rather strict genetic sex determinism system, rainbow trout sex differentiation can be modulated by temperature, as described in many other fish species.

  11. Attribute-Based Signcryption: Signer Privacy, Strong Unforgeability and IND-CCA Security in Adaptive-Predicates Model (Extended Version

    Directory of Open Access Journals (Sweden)

    Tapas Pandit

    2016-08-01

    Full Text Available Attribute-Based Signcryption (ABSC is a natural extension of Attribute-Based Encryption (ABE and Attribute-Based Signature (ABS, where one can have the message confidentiality and authenticity together. Since the signer privacy is captured in security of ABS, it is quite natural to expect that the signer privacy will also be preserved in ABSC. In this paper, first we propose an ABSC scheme which is weak existential unforgeable and IND-CCA secure in adaptive-predicates models and, achieves signer privacy. Then, by applying strongly unforgeable one-time signature (OTS, the above scheme is lifted to an ABSC scheme to attain strong existential unforgeability in adaptive-predicates model. Both the ABSC schemes are constructed on common setup, i.e the public parameters and key are same for both the encryption and signature modules. Our first construction is in the flavor of CtE&S paradigm, except one extra component that will be computed using both signature components and ciphertext components. The second proposed construction follows a new paradigm (extension of CtE&S , we call it “Commit then Encrypt and Sign then Sign” (CtE&S . The last signature is generated using a strong OTS scheme. Since, the non-repudiation is achieved by CtE&S paradigm, our systems also achieve the same.

  12. [Eugen Helimski, Urlike Kahrs. Nordselkupisches Wörterbuch von F. G. Mal'cev (1903)] / Ago Künnap

    Index Scriptorium Estoniae

    Künnap, Ago, 1941-

    2003-01-01

    Raamatust: Helimski, Eugen, Kahrs, Urlike. Nordselkupisches Wörterbuch von F. G. Mal'cev (1903). Hamburg, 2001. (Hamburger Sibirische und Finnisch-Ugrische Materialen / Habent Sua Fata Manuscripts; 1)

  13. La Seducción del mal en estrella distante de Roberto Bolaño

    OpenAIRE

    Montes, Cristian

    2013-01-01

    En el presente artículo se trabajará en torno a la novela Estrella distante de Roberto Bolaño. La intención del análisis será demostrar cómo se expresa y opera la seducción del mal al interior de la representación y proponer cuáles son las formas en que el mal encarna en una figura representativa de la dictadura militar chilena. This article is based on the Roberto Bolaño novel Estrella Distante. The analysis aims to demonstrate the ways that the seduction of evil is expressed and operates...

  14. Une localisation exceptionnelle de la tuberculose vertébrale Mal de Pott sous-occipital

    Science.gov (United States)

    Yahyaoui, Sana; Majdoub, Senda; Zaghouani, Houneida; Fradj, Hosni Ben; Bakir, Dejla; Bouajina, Elyes; Kraiem, Chakib

    2013-01-01

    Le mal de Pott est la forme la plus commune de la tuberculose osseuse touchant essentiellement le rachis dorso-lombaire. La localisation sous-occipitale reste exceptionnelle. Le diagnostic de cette entité est le plus souvent tardif ce qui expose à des complications graves. Les radiographies standard ne sont parlantes qu’à un stade tardif de la maladie, d'où l'intérêt de l'imagerie moderne notamment la tomodensitométrie (TDM) et l'imagerie par résonance magnétique (IRM) qui permettent un diagnostic précoce. Nous rapportons un nouveau cas de tuberculose sous-occipitale. Le diagnostic était posé sur l'imagerie en coupe et confirmé histologiquement à la biopsie transorale. Sont rappelés les aspects en imagerie de cette localisation particulière du mal de Pott. PMID:23819005

  15. Rotational Mal-Alignment after Reamed Intramedullary Nailing for tibial shaft fracture.

    Science.gov (United States)

    Khan, Sher Baz; Mohib, Yasir; Rashid, Rizwan Haroon; Rashid, Haroonur

    2016-10-01

    Intra-medullary (IM) nailing is standard of care for unstable tibial shaft fractures. Malrotation is very common but it is under-recognised, inpart because of variation in normal anatomy and partly due to difficulty in accurately assessing rotation. This study was planned to evaluate the frequency of rotational mal-alignment after reamed tibia IMnailing. This cross-sectional study was conducted at Aga khan University Hospital, Karachi, and comprised patients with tibia shaft fractures managed with IMnailing from January to December 2014. All the patients were assessed intra-operatively for rotational alignment using the knee and ankle fluoroscopic images. There were 81 patients with a mean age of 38±16.9 years. There were 64(79%) male patients. Overall the incidence of malrotation was in 20(24.7%) cases. Rotational mal-alignment is one of the preventable complications after IMnailing which can be assesed intra-operatively under fluoroscope.

  16. SmartMal: a service-oriented behavioral malware detection framework for mobile devices.

    Science.gov (United States)

    Wang, Chao; Wu, Zhizhong; Li, Xi; Zhou, Xuehai; Wang, Aili; Hung, Patrick C K

    2014-01-01

    This paper presents SmartMal--a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA) concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server's main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users' regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices.

  17. ANALISA PERBEDAAN MOTIVASI DAN PERSEPSI BERBELANJA DI MAL ANTARA ORANG TUA (IBU DAN PARA REMAJA PUTRINYA

    Directory of Open Access Journals (Sweden)

    Sasung Luckytawati

    2008-10-01

    The conceptual framework consists of the following constructs: consumption motivation social and con umption motivation objective as independent variables, and Mall Perception that consist ambience, design, layout, variety, excitement, involvement, desire to stay and desire to return as dependent variable. Moreover, five hypotheses were developed and tested. instrument test of validity and reliability used to test the measures, while independent t-test and multiple regressions were used in hypotheses testing. Data were collected from 100 dyadic pairs of mothers and daughters who had recently visited Mal at Jakarta. The resuIts indicate that mothers and daughters are motivated to consume by different factors, and tha they differ significantly in terms of their perceptions of critical mal environmental variables. Keywords: Consumption motivation social, Consumer behaviour, Mall Perception, and Design factors.

  18. Delayed surgical treatment for neglected or mal-reduced talar fractures.

    Science.gov (United States)

    Huang, Peng-Ju; Cheng, Yuh-Min

    2005-10-01

    From 1993 to 2002, we treated nine patients for neglected or mal-reduced talar fractures. Average patient age was 39 (20-64) years and average follow-up 53 months. The time interval between injury and index operation ranged from 4 weeks to 4 years. Surgical procedures included open reduction with or without bone grafting in six cases, open reduction combined with ankle fusion in one case, talar neck osteotomy in one case, and talar neck osteotomy combined with subtalar fusion in one case. All cases had solid bone union. One patient developed avascular necrosis of the talus needing subsequent ankle arthrodesis. In six patients, adjacent hindfoot arthrosis occurred. The overall AOFAS ankle-hindfoot score was in average 77.4. We conclude that in neglected and mal-reduced talar fractures, surgical treatment can lead to a favourable outcome if the hindfoot joints are not arthritic.

  19. Ablative fractional laser enhances MAL-induced PpIX accumulation

    DEFF Research Database (Denmark)

    Haak, C S; Christiansen, K; Erlendsson, Andrés M

    2016-01-01

    BACKGROUND AND OBJECTIVES: Pretreatment of skin with ablative fractional laser enhances accumulation of topical provided photosensitizer, but essential information is lacking on the interaction between laser channel densities and pharmacokinetics. Hence our objectives were to investigate how...... (range 46-133min) induced fluorescence levels similar to curettage and 180min incubation. Furthermore, MAL 80 and 160mg/g induced similar fluorescence intensities in skin exposed to laser densities of 1, 2 and 5% (p>0.0537, 30-180min). CONCLUSION: MAL-induced protoporphyrin accumulation is augmented...... protoporphyrin accumulation was affected by laser densities, incubation time and drug concentration. METHODS: We conducted the study on the back of healthy male volunteers (n=11). Test areas were pretreated with 2940nm ablative fractional Er:YAG laser, 11.2mJ per laser channel using densities of 1, 2, 5, 10...

  20. Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum

    International Nuclear Information System (INIS)

    Holmes, Margaret A.; Buckner, Frederick S.; Van Voorhis, Wesley C.; Mehlin, Christopher; Boni, Erica; Earnest, Thomas N.; DeTitta, George; Luft, Joseph; Lauricella, Angela; Anderson, Lori; Kalyuzhniy, Oleksandr; Zucker, Frank; Schoenfeld, Lori W.; Hol, Wim G. J.; Merritt, Ethan A.

    2006-01-01

    The crystal structure of a conserved hypothetical protein, MAL13P1.257 from P. falciparum, has been determined at 2.17 Å resolution. The structure represents a new protein fold and is the first structural representative for Pfam sequence family PF05907. The structure of a conserved hypothetical protein, PlasmoDB sequence MAL13P1.257 from Plasmodium falciparum, Pfam sequence family PF05907, has been determined as part of the structural genomics effort of the Structural Genomics of Pathogenic Protozoa consortium. The structure was determined by multiple-wavelength anomalous dispersion at 2.17 Å resolution. The structure is almost entirely β-sheet; it consists of 15 β-strands and one short 3 10 -helix and represents a new protein fold. The packing of the two monomers in the asymmetric unit indicates that the biological unit may be a dimer.

  1. Torsional vibration analysis in turbo-generator shaft due to mal-synchronization fault

    Science.gov (United States)

    Bangunde, Abhishek; Kumar, Tarun; Kumar, Rajeev; Jain, S. C.

    2018-03-01

    A rotor of turbo-generator shafting is many times subjected to torsional vibrations during its lifespan. The reasons behind these vibrations are three-Phase fault, two-phase fault, line to ground fault, faulty-mal synchronization etc. Sometimes these vibrations can cause complete failure of turbo-generator shafting system. To calculate moment variation during these faults on the shafting system vibration analysis is done using Finite Elements Methods to calculate mass and stiffness matrix. The electrical disturbance caused during Mal-synchronization is put on generator section, and corresponding second order equations are solved by using “Duhamel Integral”. From the moment variation plots at four sections critically loaded sections are identified.

  2. Magnetic moment of short lived {beta}-emitter {sup 24m}Al

    Energy Technology Data Exchange (ETDEWEB)

    Nishimura, D., E-mail: daiki@vg.phys.sci.osaka-u.ac.jp; Komurasaki, J.; Matsuta, K.; Mihara, M.; Matsumiya, R. [Osaka University, Department of Physics (Japan); Momota, S. [Kochi University of Technology (Japan); Ohtsubo, T. [Niigata University, Department of Physics (Japan); Izumikawa, T. [Niigata University, RI Center (Japan); Hirano, H. [Niigata University, Department of Physics (Japan); Kitagawa, A.; Kanazawa, M.; Torikoshi, M.; Sato, S. [National Institute of Radiological Sciences (Japan); Fukuda, M.; Ishikawa, D. [Osaka University, Department of Physics (Japan); Minamisono, T. [Fukui University of Technology (Japan); Watanabe, R.; Kubo, T. [Niigata University, Department of Physics (Japan); Nojiri, Y. [Kochi University of Technology (Japan); Alonso, J. R. [Lawrence Berkeley Laboratory (United States)

    2007-11-15

    The magnetic moment of short lived {beta}-emitter {sup 24m}Al (426 keV, I{sup {pi}} = 1{sup +}, T{sub 1/2} = 131 ms) has been measured by means of {beta}-NMR technique, for the first time. From the {beta}-NMR spectrum, the magnetic moment was determined as |{mu}({sup 24m}Al)|=(2.99{+-}0.09){mu}{sub N}. Combined with the known magnetic moment of the mirror partner {sup 24m}Na, the expectation value of < S{sub z} > is obtained to be (0.08 {+-} 0.12). These values are reproduced well by the shell model calculation.

  3. Theoretical Characteristics of Metalloporphyrins (OEP) M (CH 3 ) (M=Al, Ga, In and Tl)

    OpenAIRE

    Lepetit , M.B.; Kabbaj , O.K.; Zrineh , A.

    2017-01-01

    International audience; A theoretical study of metalloporphyrins molecules (OEP) M (CH 3) (M=Al, Ga, In and Tl) are brought to a few experimental data and to give background for future development of these complexes. The Quantum Chemistry Program (ORCA) program package based on Density Functional Theory (DFT) and Time-dependent Density Functional Theory (TDDFT) for transitions at the B3LYP level with ANO 2ζ+P base was used for calculations and determination of structural properties, electroni...

  4. The (Mal)Practice of Dowry in Contemporary India. A Challenge to Marriage and Family Ministry

    OpenAIRE

    Jainus Xavier, Nixen Raj; Jainus Xavier, Nixen Raj; Knieps-Port le Roi, Thomas

    2012-01-01

    The author explores the (mal)practice of dowry in contemporary India and the challenge it presents to marriage and family ministry. He explains how originally harmless and well-intended dowry customs changed under the influence of historical circumstances that turned them into a business-like family strategy aimed at rising families’ social status, wealth and power. This evolution had dramatic consequences for Indian marriage and family life and especially for women. Dowry-related violence an...

  5. Hybrid (laparoscopy + stent) treatment of celiac trunk compression syndrome (Dunbar syndrome, median arcuate ligament syndrome (MALS)).

    Science.gov (United States)

    Michalik, Maciej; Dowgiałło-Wnukiewicz, Natalia; Lech, Paweł; Majda, Kaja; Gutowski, Piotr

    2016-01-01

    Celiac trunk (CT) compression syndrome caused by the median arcuate ligament (MAL) is a rarely diagnosed disease because of its nonspecific symptoms, which cause a delay in the correct diagnosis. Intestinal ischemia occurs, which causes symptoms of abdominal angina. One method of treatment for this disease is surgical release of the CT - the intersection of the MAL. Laparoscopy is the first step of the hybrid technique combined with percutaneous angioplasty and stenting of the CT. To demonstrate the usefulness and advantages of the laparoscopic approach in the treatment of Dunbar syndrome. Between 2013 and 2016 in the General and Minimally Invasive Surgery Department of the Medical Sciences Faculty of the University of Warmia and Mazury in Olsztyn, 6 laparoscopic procedures were performed because of median arcuate ligament syndrome. During the laparoscopy the MAL was cut with a harmonic scalpel. One month after laparoscopy 5 patients had Doppler percutaneous angioplasty of the CT with stent implantation in the Vascular Surgery Department in Pomeranian Medical University in Szczecin. In one case, there was a conversion of laparoscopic surgery to open due to unmanageable intraoperative bleeding. In one case, postoperative ultrasound examination of the abdominal cavity demonstrated the presence of a large hematoma in the retroperitoneal space. All patients reported relief of symptoms in the first days after the operation. The hybrid method, combining laparoscopy and angioplasty, seems to be a long-term solution, which increases the comfort of the patient, brings the opportunity for normal functioning and minimizes the risk of restenosis.

  6. MAL2 and tumor protein D52 (TPD52 are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

    Directory of Open Access Journals (Sweden)

    Fanayan Susan

    2010-09-01

    Full Text Available Abstract Background The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12. Independent expression microarray studies predict MAL2 overexpression in ovarian carcinoma, but these had remained unconfirmed. MAL2 binds tumor protein D52 (TPD52, which is frequently overexpressed in ovarian carcinoma, but the clinical significance of MAL2 and TPD52 overexpression was unknown. Methods Immunohistochemical analyses of MAL2 and TPD52 expression were performed using tissue microarray sections including benign, borderline and malignant epithelial ovarian tumours. Inmmunohistochemical staining intensity and distribution was assessed both visually and digitally. Results MAL2 and TPD52 were significantly overexpressed in high-grade serous carcinomas compared with serous borderline tumours. MAL2 expression was highest in serous carcinomas relative to other histological subtypes, whereas TPD52 expression was highest in clear cell carcinomas. MAL2 expression was not related to patient survival, however high-level TPD52 staining was significantly associated with improved overall survival in patients with stage III serous ovarian carcinoma (log-rank test, p Conclusions MAL2 is frequently overexpressed in ovarian carcinoma, and TPD52 overexpression is a favourable independent prognostic marker of potential value in the management of ovarian carcinoma patients.

  7. Maltase protein of Ogataea (Hansenula) polymorpha is a counterpart to the resurrected ancestor protein ancMALS of yeast maltases and isomaltases

    Science.gov (United States)

    Viigand, Katrin; Visnapuu, Triinu; Mardo, Karin; Aasamets, Anneli

    2016-01-01

    Abstract Saccharomyces cerevisiae maltases use maltose, maltulose, turanose and maltotriose as substrates, isomaltases use isomaltose, α‐methylglucoside and palatinose and both use sucrose. These enzymes are hypothesized to have evolved from a promiscuous α‐glucosidase ancMALS through duplication and mutation of the genes. We studied substrate specificity of the maltase protein MAL1 from an earlier diverged yeast, Ogataea polymorpha (Op), in the light of this hypothesis. MAL1 has extended substrate specificity and its properties are strikingly similar to those of resurrected ancMALS. Moreover, amino acids considered to determine selective substrate binding are highly conserved between Op MAL1 and ancMALS. Op MAL1 represents an α‐glucosidase in which both maltase and isomaltase activities are well optimized in a single enzyme. Substitution of Thr200 (corresponds to Val216 in S. cerevisiae isomaltase IMA1) with Val in MAL1 drastically reduced the hydrolysis of maltose‐like substrates (α‐1,4‐glucosides), confirming the requirement of Thr at the respective position for this function. Differential scanning fluorimetry (DSF) of the catalytically inactive mutant Asp199Ala of MAL1 in the presence of its substrates and selected monosaccharides suggested that the substrate‐binding pocket of MAL1 has three subsites (–1, +1 and +2) and that binding is strongest at the –1 subsite. The DSF assay results were in good accordance with affinity (K m) and inhibition (K i) data of the enzyme for tested substrates, indicating the power of the method to predict substrate binding. Deletion of either the maltase (MAL1) or α‐glucoside permease (MAL2) gene in Op abolished the growth of yeast on MAL1 substrates, confirming the requirement of both proteins for usage of these sugars. © 2016 The Authors. Yeast published by John Wiley & Sons, Ltd. PMID:26919272

  8. Performances of air source heat pump system for a kind of mal-defrost phenomenon appearing in moderate climate conditions

    International Nuclear Information System (INIS)

    Wang, W.; Feng, Y.C.; Zhu, J.H.; Li, L.T.; Guo, Q.C.; Lu, W.P.

    2013-01-01

    Highlights: ► Mal-defrost performances of ASHP in moderate environment are investigated. ► The system COP decreases to 2.3 under environment temperature of 7.9 °C. ► The decrease of the ASHP heating capacity can get to 43.4%. ► The origins of this special mal-defrost phenomenon were discussed. ► Suggestions were proposed to modify the current defrosting control strategies. - Abstract: To quantify the performance drop of the air source heat pump (ASHP) system under a special kind of mal-defrost phenomenon appearing in moderate climate conditions, a field test was conducted for 8 days at the initial stage of a heating season in Beijing, China. The mal-defrost was found with the more than 60% frosted area of the outdoor heat exchanger after the system running 5 days. During this frosting period, the system COP was significantly degraded, only 2.3 under an environment temperature of 7.9 °C. Comparing the test data before and after frosting, it was found that the mal-defrost decreased the COP up to 40.4% and the heating capacity to 43.4%. Such low energy efficiency continued quite a long time until the defrost control was started up manually by the authors. After defrosting, the COP reclaimed to the normal level of 5.0. The origins of this special mal-defrost phenomenon were discussed. And some suggestions were proposed to modify the current defrosting control strategy, which were helpful to avoid the mal-defrost problem in the current ASHP system and therefore improve the system performances

  9. Contact-induced change or dialectal relic in heritage American-Danish? The use of the indefinite article in copula clauses with person-identifying subject predicate

    DEFF Research Database (Denmark)

    Heegård, Jan

    2018-01-01

    The article analyses the use and non-use of the indefinite article in the identifying copula construction with bare noun as the subject predicate in American Danish. With a point of departure in the semantics associated with use and non-use of the indefinite article in Standard Danish and Danish ...

  10. Pequeno mal epiléptico em crianças. Considerações sobre o efeito do tridione em 4 casos

    Directory of Open Access Journals (Sweden)

    Antonio B. Lefévre

    1949-03-01

    Full Text Available The author administered Tridione in four patients under five years of age with "petit mal" seizures. In all cases there was complete disappearance of the seizures eventhough small doses were used. In one case the EEG, taken after the Tridione treatment, did not show the previous "petit mal" pattern. In no case there were signs of intolerance. In conclusion the author thoroughly agree that Tridione is the drug of choice in "petit mal" seizures.

  11. DMPD: The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 17449723 The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. Sh...Show The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. PubmedID 17449723 Title The Tro...ll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling. Authors Sheedy F

  12. Luminescence properties of Eu2+-doped MAl2-xSixO4-xNx (M = Ca, Sr, Ba) conversion phosphor for white LED applications

    NARCIS (Netherlands)

    Li, Y.Q.; With, de G.; Hintzen, H.T.J.M.

    2006-01-01

    Undoped and Eu-doped MAl2-xSixO4-2Nx (M = Ca, Sr, Ba) were synthesized by a solid-state reaction method at 1300 - 1400 ¿C under nitrogen-hydrogen atmosphere. The solubility of (SiN)+, in MAl2O4 was determined. Nitrogen can be incorporated into MAl2O4 by replacement of (AlO)+ by (SiN)+, whose amount

  13. Malária grave em gestantes Severe malaria in pregnant women

    Directory of Open Access Journals (Sweden)

    Flavia Barbosa Fernandes

    2010-12-01

    Full Text Available OBJETIVO: analisar a evolução clínica de três pacientes grávidas com malária grave internadas em unidade de terapia intensiva de um hospital localizado em Porto Velho (RO. MÉTODOS: foi realizado estudo descritivo em três gestantes, portadoras de malária por Plasmodium falciparum, internadas em unidade de terapia intensiva em Porto Velho, no período de 2005 a 2006. As variáveis categóricas utilizadas foram os critérios de classificação da Organização Mundial de Saúde para classificação de malária grave e os índices Acute Physiology and Chronic Health disease Classification System II (APACHE II e Sepsis Related Organ Failure Assessment (SOFA preditores de morbidade e gravidade das doenças em unidade de terapia intensiva. RESULTADOS: a malária adquirida pelas gestantes, caracterizada pela infecção por Plasmodium falciparum na forma grave da doença, resultou em óbito para as três pacientes e seus conceptos. CONCLUSÕES: embora a casuística seja pequena, a importância deste estudo reflete a repercussão da malária grave em gestantes, bem como a necessidade de um acompanhamento pré-natal mais criterioso e atento à identificação precoce do início das complicações da malária em gestantes.PURPOSE: to analyze the clinical course of three pregnant patients with severe malaria admitted to the intensive care unit of a hospital in Porto Velho (RO, Brazil. METHODS: a descriptive study was conducted on three pregnant women infected with Plasmodium falciparum malaria, admitted to the intensive care unit of a hospital in Porto Velho from 2005 to 2006. Categorical variables used were the classification criteria of the World Health Organization which ranks severe malaria and the Acute Physiology and Chronic Health Disease Classification System II (APACHE II and Sepsis Related Organ Failure Assessment (SOFA predictors of morbidity and severity of intensive care unit diseases. RESULTS: the malaria acquired by the pregnant

  14. Hybrid (laparoscopy + stent treatment of celiac trunk compression syndrome (Dunbar syndrome, median arcuate ligament syndrome (MALS

    Directory of Open Access Journals (Sweden)

    Maciej Michalik

    2016-12-01

    Full Text Available Introduction : Celiac trunk (CT compression syndrome caused by the median arcuate ligament (MAL is a rarely diagnosed disease because of its nonspecific symptoms, which cause a delay in the correct diagnosis. Intestinal ischemia occurs, which causes symptoms of abdominal angina. One method of treatment for this disease is surgical release of the CT – the intersection of the MAL. Laparoscopy is the first step of the hybrid technique combined with percutaneous angioplasty and stenting of the CT. Aim: To demonstrate the usefulness and advantages of the laparoscopic approach in the treatment of Dunbar syndrome. Material and methods : Between 2013 and 2016 in the General and Minimally Invasive Surgery Department of the Medical Sciences Faculty of the University of Warmia and Mazury in Olsztyn, 6 laparoscopic procedures were performed because of median arcuate ligament syndrome. During the laparoscopy the MAL was cut with a harmonic scalpel. One month after laparoscopy 5 patients had Doppler percutaneous angioplasty of the CT with stent implantation in the Vascular Surgery Department in Pomeranian Medical University in Szczecin. Results : In one case, there was a conversion of laparoscopic surgery to open due to unmanageable intraoperative bleeding. In one case, postoperative ultrasound examination of the abdominal cavity demonstrated the presence of a large hematoma in the retroperitoneal space. All patients reported relief of symptoms in the first days after the operation. Conclusions : The hybrid method, combining laparoscopy and angioplasty, seems to be a long-term solution, which increases the comfort of the patient, brings the opportunity for normal functioning and minimizes the risk of restenosis.

  15. PERTANGGUNGAN JAWAB PIDANA PEJABAT ATAS TINDAKAN MAL-ADMINISTRASI DALAM PENERBITAN IZIN DI BIDANG LINGKUNGAN

    Directory of Open Access Journals (Sweden)

    Ahmad Basuki

    2011-09-01

    Full Text Available The democratic strengthen is very influencing to the demand of good governance in managing the government. One of the positive demand is it has been adopted the principle of accountability of the constitution of protection and management of environment for official functionary on the act of mal administration in establishing permit of environment field, Based on the principle community who become sacrifice of pollution of environment can appeal the legal permit and the responsibility of criminal case towards the official functionary of disadvantages they have got.

  16. Kärnproblem : opinionsbildning i kärnavfallsdiskursen i Malå

    OpenAIRE

    Sjölander, Annika

    2004-01-01

    At the centre of this study lies one of the critical questions faced by (late-)modern society, namely that of taking care of the long-lived radioactive waste from nuclear power production. The problems of nuclear waste management are pictured as embracing a complex web of essential issues for society today, in terms of both its capacities and its shortcomings – so called core issues. The principal aim of the thesis is to examine the nuclear waste discourse in Malå, Västerbotten, from a critic...

  17. No hay mal que por bien no venga: el optimismo según Rousseau

    OpenAIRE

    Baranzelli, Dante A.

    2004-01-01

    El deísmo rousseauniano desestima la existencia del caos o del Mal general. Por el contrario, ve en el sistema del mundo un orden perfecto que obedece a la divina Providencia, identificada con la legalidad universal de la naturaleza. Mas con ello su intención no es despreciar el sufrimiento de los individuos. De hecho Rousseau reconoce y admite la presencia, e incluso la abundancia, de diversos males que afectan al hombre. ¿Acaso él mismo no es un claro ejemplo de ello?

  18. Escaping History: Benjamin Fondane's 'Mal des fantômes' and Interiority

    OpenAIRE

    Dickow, A

    2017-01-01

    AbstractThis article undertakes a detailed comparison of the work of Emmanuel Levinas and the poet-philosopher Benjamin Fondane. Fondane’s most iconic poem, quoted at the entrance to the Hall of Names in Jerusalem’s Holocaust museum, resembles a poetic illustration of Levinas’s key themes, such as the ‘face’ and the concept of ‘ethical speech.’ Likewise, Fondane’s long poem ‘Le Mal des fantômes’ illustrates Levinas and Fondane’s shared conception of the subject’s interiority and day-to-day ex...

  19. Exposure to Glycolytic Carbon Sources Reveals a Novel Layer of Regulation for the MalT Regulon

    Directory of Open Access Journals (Sweden)

    Sylvia A. Reimann

    2011-01-01

    Full Text Available Bacteria adapt to changing environments by means of tightly coordinated regulatory circuits. The use of synthetic lethality, a genetic phenomenon in which the combination of two nonlethal mutations causes cell death, facilitates identification and study of such circuitry. In this study, we show that the E. coli ompR malTcon double mutant exhibits a synthetic lethal phenotype that is environmentally conditional. MalTcon, the constitutively active form of the maltose system regulator MalT, causes elevated expression of the outer membrane porin LamB, which leads to death in the absence of the osmoregulator OmpR. However, the presence and metabolism of glycolytic carbon sources, such as sorbitol, promotes viability and unveils a novel layer of regulation within the complex circuitry that controls maltose transport and metabolism.

  20. De culpable a perseguido: Baudelaire y el proceso de Las Flores del Mal

    Directory of Open Access Journals (Sweden)

    Juan Zapata

    2018-01-01

    Full Text Available ¿Cómo el poeta de Las Flores del Mal pasó de ser un escritor proscrito, y en consecuencia sospechoso, al autor perseguido e incomprendido que ha inmortalizado la historia literaria? ¿Cómo Baudelaire pudo desviar a su favor una circunstancia que, a primera  vista, era desafortunada? Baudelaire supo utilizar el escándalo que provocó la publicación de Las Flores del Mal para promover su figura pública. Un análisis de las posturas discursivas desplegadas por Baudelaire antes, durante y después del proceso nos permitirá comprender mejor la inversión que el poeta hace de su condenación, al transformar la sanción penal y moral, así como la exclusión a la que esta conduce, en un signo de su grandeza y de su gloria póstuma.

  1. A review of the prevalence and factors responsible for mal-nutrition in Pakistan

    Directory of Open Access Journals (Sweden)

    Hafsa Hina

    2015-01-01

    Full Text Available Problems occupying special attention identified by the World Health Organization also include Childhood malnutrition (Beagle hole et al., 1993. Development goals are also program by the United Nations to halve the problem of under nutrition (Alderman et al., 2005. Despite of the involvement of international organizations still under nutrition has a main contribution to the high mortality rate of the children in the most part of the world (Caulfield et al., 2004. Poverty plays a main part in the high prevalence of childhood under nutrition. The child is said to be under-weight when its weight is lower than the weight of the reference rage for that age. The weight for height deficiency is known as wasting, while height for age deficiency as stunting. Wasting may be due to acute food shortage while prolonged food deprivation can cause stunting (Cosminsky et al., 1993; de Onis et al., 2000; Fernandez et al., 2002; and Zere & McIntyre, 2003. The factors responsible for the predisposition of children to mal nutrition vary and ranges from political instability to the economical status of the area (de Onis et al., 2000. Therefore protocols developed for the preventive measures of mal-nutrition should be multifaceted. 

  2. Olhar de dirigentes sindicais sobre qualidade de vida no trabalho e mal-estar no trabalho

    Directory of Open Access Journals (Sweden)

    Remigio Todeschini

    2013-06-01

    Full Text Available O objeto do artigo consistiu em conhecer as percepções de dirigentes sindicais metalúrgicos e químicos sobre o tema Qualidade de Vida no Trabalho (QVT e as fontes de mal-estar no trabalho nessas categorias profissionais. A natureza metodológica aplicada foi quantitativa e qualitativa com utilização do software Alceste. Participaram da pesquisa 81 dirigentes sindicais brasileiros (56 dirigentes químicos e 25 metalúrgicos, 85% do gênero masculino e 15% do gênero feminino oriundos das regiões sudeste, sul e nordeste do país, com aplicação do questionário via e-mail. Os resultados encontrados forneceram bases empíricas para a formulação de recomendações em Ergonomia da Atividade visando prevenir as fontes de mal-estar no trabalho. Foram reforçadas as bases teóricas da Abordagem de Ergonomia da Atividade Aplicada à Qualidade de Vida no Trabalho (EAA_QVT e o desenho de subsídios para a formulação de políticas públicas neste campo.

  3. The use of plasma rich in growth factors (PRGF-Endoret) in the treatment of a severe mal perforant ulcer in the foot of a person with diabetes.

    Science.gov (United States)

    Orcajo, Beatriz; Muruzabal, Francisco; Isasmendi, María Concepción; Gutierrez, Nerea; Sánchez, Mikel; Orive, Gorka; Anitua, Eduardo

    2011-08-01

    A 71 year old person with diabetes with a severe mal perforant ulcer in the right foot was treated twice with autologous plasma-rich in growth factors (PRGF) obtained from her own blood. After PRGF treatment the severe mal perforant ulcer completely healed in 10 weeks. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  4. Association of Mal/TIRAP S180L variant polymorphism with decreased infection risk in patients with advanced HIV-1 infection.

    NARCIS (Netherlands)

    Papadopoulos, A.I.; Ferwerda, B.; Antoniadou, A.; Sakka, V.; Galani, L.; Kavatha, D.; Panagopoulos, P.; Poulakou, G.; Protopapas, K.; Meer, J.W.M. van der; Netea, M.G.; Giamarellos-Bourboulis, E.J.

    2012-01-01

    OBJECTIVES: MyD88 adaptor-like (Mal/TIRAP) is an adaptor protein bridging activation of Toll-like receptors 2 and 4 after stimulation by exogenous and endogenous ligands. We investigated the association between the presence of the S180L SNP of Mal and the risk of severe infection in individuals with

  5. Critical point predication device

    International Nuclear Information System (INIS)

    Matsumura, Kazuhiko; Kariyama, Koji.

    1996-01-01

    An operation for predicting a critical point by using a existent reverse multiplication method has been complicated, and an effective multiplication factor could not be plotted directly to degrade the accuracy for the prediction. The present invention comprises a detector counting memory section for memorizing the counting sent from a power detector which monitors the reactor power, a reverse multiplication factor calculation section for calculating the reverse multiplication factor based on initial countings and current countings of the power detector, and a critical point prediction section for predicting the criticality by the reverse multiplication method relative to effective multiplication factors corresponding to the state of the reactor core previously determined depending on the cases. In addition, a reactor core characteristic calculation section is added for analyzing an effective multiplication factor depending on the state of the reactor core. Then, if the margin up to the criticality is reduced to lower than a predetermined value during critical operation, an alarm is generated to stop the critical operation when generation of a period of more than a predetermined value predicted by succeeding critical operation. With such procedures, forecasting for the critical point can be easily predicted upon critical operation to greatly mitigate an operator's burden and improve handling for the operation. (N.H.)

  6. MAL2 and tumor protein D52 (TPD52) are frequently overexpressed in ovarian carcinoma, but differentially associated with histological subtype and patient outcome

    International Nuclear Information System (INIS)

    Byrne, Jennifer A; Sutherland, Robert L; Fazio, Anna de; O'Brien, Philippa M; Maleki, Sanaz; Hardy, Jayne R; Gloss, Brian S; Murali, Rajmohan; Scurry, James P; Fanayan, Susan; Emmanuel, Catherine; Hacker, Neville F

    2010-01-01

    The four-transmembrane MAL2 protein is frequently overexpressed in breast carcinoma, and MAL2 overexpression is associated with gain of the corresponding locus at chromosome 8q24.12. Independent expression microarray studies predict MAL2 overexpression in ovarian carcinoma, but these had remained unconfirmed. MAL2 binds tumor protein D52 (TPD52), which is frequently overexpressed in ovarian carcinoma, but the clinical significance of MAL2 and TPD52 overexpression was unknown. Immunohistochemical analyses of MAL2 and TPD52 expression were performed using tissue microarray sections including benign, borderline and malignant epithelial ovarian tumours. Inmmunohistochemical staining intensity and distribution was assessed both visually and digitally. MAL2 and TPD52 were significantly overexpressed in high-grade serous carcinomas compared with serous borderline tumours. MAL2 expression was highest in serous carcinomas relative to other histological subtypes, whereas TPD52 expression was highest in clear cell carcinomas. MAL2 expression was not related to patient survival, however high-level TPD52 staining was significantly associated with improved overall survival in patients with stage III serous ovarian carcinoma (log-rank test, p < 0.001; n = 124) and was an independent predictor of survival in the overall carcinoma cohort (hazard ratio (HR), 0.498; 95% confidence interval (CI), 0.34-0.728; p < 0.001; n = 221), and in serous carcinomas (HR, 0.440; 95% CI, 0.294-0.658; p < 0.001; n = 182). MAL2 is frequently overexpressed in ovarian carcinoma, and TPD52 overexpression is a favourable independent prognostic marker of potential value in the management of ovarian carcinoma patients

  7. Pathogenicity of Phytophthora austrocedrae on Austrocedrus chilensis and its relation with mal del ciprés in Patagonia

    Science.gov (United States)

    A. G. Greslebin; E. M. Hansen

    2010-01-01

    Field observations, isolations and pathogenicity tests were performed on Austrocedrus chilensis (Cupressaceae) trees to determine the pathogenicity of Phytophthora austrocedrae and its role in the aetiology of the cypress disease mal del ciprés (MDC) in Argentina. It was found that P. austrocedrae...

  8. La Justificación de la Presencia del Mal en el Mundo desde la Estética Agustiniana

    Directory of Open Access Journals (Sweden)

    David Ezequiel Téllez Maqueo

    2016-07-01

    Full Text Available La posibilidad de establecer una conciliación entre Dios como principio absoluto de bondad, y el mal presente en la realidad en sus más diversas manifestaciones (miseria, guerras, enfermedad, ignorancia, etc., ha sido una preocupación constante en la historia del pensamiento occidental. Si Dios existe, ¿cómo puede suceder que exista mal en el mundo? Para dar una respuesta racional satisfactoria se han planteado diversas respuestas. Pero Agustin de Hipona representa la primera teodicea dominante de la historia occidental, por lo que el conocimiento de su postura ante este problema es digno de interés. Para ello, el objetivo de estas líneas es triple: 1 establecer en qué consiste la solución estética de san Agustin al problema del mal, II señalar algunas de las críticas más conocidas que ha recibido en el siglo XX, y III afirmar que la solución agustiniana puede seguir siendo base de una teodicea capaz de hacer compatible la existencia de Dios y el mal en el mundo, tras la valoración de las distintas posturas críticas que ha recibido.

  9. Characterization of recombinant Mal d 4 and its application for component-resolved diagnosis of apple allergy

    NARCIS (Netherlands)

    Ma, Y.; Zuidmeer, L.; Bohle, B.; Bolhaar, S. T. H.; Gadermaier, G.; Gonzalez-Mancebo, E.; Fernandez-Rivas, M.; Knulst, A. C.; Himly, M.; Asero, R.; Ebner, C.; van Ree, R.; Ferreira, F.; Breiteneder, H.; Hoffmann-Sommergruber, K.

    2006-01-01

    BACKGROUND: Profilins are ubiquitous panallergens that have been extensively characterized; yet, their clinical relevance is still unclear. OBJECTIVE: The aim of the present study was to produce recombinant apple profilin (rMal d 4) and to evaluate its allergenic activity and its potency for

  10. A Novel Bifunctional Amino Acid Racemase With Multiple Substrate Specificity, MalY From Lactobacillus sakei LT-13: Genome-Based Identification and Enzymological Characterization

    Directory of Open Access Journals (Sweden)

    Shiro Kato

    2018-03-01

    Full Text Available The Lactobacillus sakei strain LK-145 isolated from Moto, a starter of sake, produces potentially large amounts of three D-amino acids, D-Ala, D-Glu, and D-Asp, in a medium containing amylase-digested rice as a carbon source. The comparison of metabolic pathways deduced from the complete genome sequence of strain LK-145 to the type culture strain of Lactobacillus sakei strain LT-13 showed that the L- and D-amino acid metabolic pathways are similar between the two strains. However, a marked difference was observed in the putative cysteine/methionine metabolic pathways of strain LK-145 and LT-13. The cystathionine β-lyase homolog gene malY was annotated only in the genome of strain LT-13. Cystathionine β-lyase is an important enzyme in the cysteine/methionine metabolic pathway that catalyzes the conversion of L-cystathionine into L-homocysteine. In addition to malY, most genome-sequenced strains of L. sakei including LT-13 lacked the homologous genes encoding other putative enzymes in this pathway. Accordingly, the cysteine/methionine metabolic pathway likely does not function well in almost all strains of L. sakei. We succeeded in cloning and expressing the malY gene from strain LT-13 (Ls-malY in the cells of Escherichia coli BL21 (DE3 and characterized the enzymological properties of Ls-MalY. Spectral analysis of purified Ls-MalY showed that Ls-MalY contained a pyridoxal 5′-phosphate (PLP as a cofactor, and this observation agreed well with the prediction based on its primary structure. Ls-MalY showed amino acid racemase activity and cystathionine β-lyase activity. Ls-MalY showed amino acid racemase activities in various amino acids, such as Ala, Arg, Asn, Glu, Gln, His, Leu, Lys, Met, Ser, Thr, Trp, and Val. Mutational analysis revealed that the -amino group of Lys233 in the primary structure of Ls-MalY likely bound to PLP, and Lys233 was an essential residue for Ls-MalY to catalyze both the amino acid racemase and β-lyase reactions. In

  11. DIREITO DE EXCEÇÃO: OS RISCOS DE UM MAL NECESSÁRIO

    Directory of Open Access Journals (Sweden)

    Mariana Belchior Ribeiro Freire

    2010-08-01

    Full Text Available O presente trabalho tem como escopo analisar o estado de exceção no seu liame entre a manutenção do status quo ante e o salto para a revolução. Sob a óptica dos pensamentos de renomados filósofos (Jean Bodin, Thomas Hobbes, Rosseau, Hans Kelsen e Carl Schmitt, procuramos analisar os benefícios e os riscos da instituição do estado de exceção, tendo em vista que se pode considerar este um mal necessário. O estado de exceção é um avanço nas democracias contemporâneas, como observaremos a sua previsão importa uma segurança à sociedade de que é possível mudar preservando alguns direitos constitucionais.

  12. Uruguay mining inventory results of the Mal Abrigo aerial photography chemical prospect ion

    International Nuclear Information System (INIS)

    Zeegers, H.; Artignan, D.; Vairon, P.

    1982-01-01

    This report presents the results of the chemical prospecting strategic multielemental carried out, of the mining Inventory framework from the Uruguay aerial photography Mal Abrigo (sector M 25, area 82). The covered surface is of 660 km with a total of 753 samples, corresponding to an approximate sampling density of 1.14 samples for krri2; in parallel pH measures and radioactivity were made. The samples were analyzed in the laboratories of the BRGM (Orleans), for 22 elements for Spectrometry of Emission Captures. The geochemical answer in connection with the litology was good. Sixteen anomalies, little contrasted has been retained in what concerns to the elements Pb, Zn, Cu, Ace, Ag, and W; eight of those which are constituted for regrouping points. The main purpose has been to search ultramafic rocs in Cerro Chato -Durazno province.

  13. SmartMal: A Service-Oriented Behavioral Malware Detection Framework for Mobile Devices

    Directory of Open Access Journals (Sweden)

    Chao Wang

    2014-01-01

    Full Text Available This paper presents SmartMal—a novel service-oriented behavioral malware detection framework for vehicular and mobile devices. The highlight of SmartMal is to introduce service-oriented architecture (SOA concepts and behavior analysis into the malware detection paradigms. The proposed framework relies on client-server architecture, the client continuously extracts various features and transfers them to the server, and the server’s main task is to detect anomalies using state-of-art detection algorithms. Multiple distributed servers simultaneously analyze the feature vector using various detectors and information fusion is used to concatenate the results of detectors. We also propose a cycle-based statistical approach for mobile device anomaly detection. We accomplish this by analyzing the users’ regular usage patterns. Empirical results suggest that the proposed framework and novel anomaly detection algorithm are highly effective in detecting malware on Android devices.

  14. Mal de Debarquement Syndrome: A Rare Entity—A Case Report and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Veronica Nwagwu

    2015-01-01

    Full Text Available Mal de Debarquement Syndrome (MDS is a rare, understudied, underdiagnosed, and self-limiting condition. Etiology and incidence are unknown. It is characterized by abnormal sensation of motion/balance reported after travel by air, land, and sea; being reexposed to motion/activity relieves it. Symptoms may last from minutes to years. Workup though required reveals no findings; it is a diagnosis of exclusion. While no efficacious treatment exists, amitriptyline and benzodiazepines as well as supportive therapy have proved to be useful. We have described a 40-year-old Caucasian female who presented for the evaluation of persistent rocking and swaying sensation after a ship cruise which lasted for one week. Patient was treated with benzodiazepines after extensive workup and is now stable. A high index of suspicion is required to make a diagnosis.

  15. malERA: An updated research agenda for malaria elimination and eradication.

    Science.gov (United States)

    Rabinovich, Regina N; Drakeley, Chris; Djimde, Abdoulaye A; Hall, B Fenton; Hay, Simon I; Hemingway, Janet; Kaslow, David C; Noor, Abdisalan; Okumu, Fredros; Steketee, Richard; Tanner, Marcel; Wells, Timothy N C; Whittaker, Maxine A; Winzeler, Elizabeth A; Wirth, Dyann F; Whitfield, Kate; Alonso, Pedro L

    2017-11-01

    Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are setting ambitious goals for reducing the burden and eliminating malaria through the "Global Technical Strategy" and 21 countries are aiming to eliminate malaria by 2020. The commitment to achieve these targets should be celebrated. However, the need for innovation to achieve these goals, sustain elimination, and free the world of malaria is greater than ever. Over 180 experts across multiple disciplines are engaged in the Malaria Eradication Research Agenda (malERA) Refresh process to address problems that need to be solved. The result is a research and development agenda to accelerate malaria elimination and, in the longer term, transform the malaria community's ability to eradicate it globally.

  16. malERA: An updated research agenda for malaria elimination and eradication.

    Directory of Open Access Journals (Sweden)

    Regina N Rabinovich

    2017-11-01

    Full Text Available Achieving a malaria-free world presents exciting scientific challenges as well as overwhelming health, equity, and economic benefits. WHO and countries are setting ambitious goals for reducing the burden and eliminating malaria through the "Global Technical Strategy" and 21 countries are aiming to eliminate malaria by 2020. The commitment to achieve these targets should be celebrated. However, the need for innovation to achieve these goals, sustain elimination, and free the world of malaria is greater than ever. Over 180 experts across multiple disciplines are engaged in the Malaria Eradication Research Agenda (malERA Refresh process to address problems that need to be solved. The result is a research and development agenda to accelerate malaria elimination and, in the longer term, transform the malaria community's ability to eradicate it globally.

  17. ACCUMULATION OF POLYHYDROXYALKANOIC ACIDS BY AZOTOBACTER CHROOCOCCUM MAL-201 FROM ORGANIC WASTE

    Directory of Open Access Journals (Sweden)

    Soma Pal Saha

    2013-08-01

    Full Text Available Azotobacter chroococcum MAL-201 (MTCC 3853, a free-living nitrogen-fixing bacterium accumulated intracellular poly(3-hydroxybutyric acid [P(3HB] accounting 69% of cell dry weight (CDW when grown in nitrogrn-free Stockdale medium containing 2% (w/v glucose. It also produced copolymer of poly(3-hydroxybutyrate co-3-hydroxyvalerate [P(3HB-co-3HV] using glucose as primary carbon source and valerate cas cosubstrate. To make the polymer production cost effective four types of waste material of different origin were tested for growth and polymer production. Stockdale medium supplemented with 1% (w/v waste materials failed to yield good growth and polymer accumulation. Two–step cultivation was adopted for better growth and enhanced polymer accumulation. The candy factory waste was most suitable for synthesis of P(3HB accounting 17.8 and 40.58% using single and two-step cultivation conditions respectively. Wastes of domestic and poultry origin produced P(3HB-co-3HV with 3HV content 28.8 and 21.5 mol% respectively in two-step cultivation. Increase concentration of these wastes resulted in further upliftment of 3HV content of polymer with reduced growth and polymer accumulation. However, at optimum incubation the strain MAL-201 cells accumulated P(3HB 48.5% of CDW (at 40h from candy factory waste and P(3HB-co-3HV 24.75 % of CDW with 3HV 34.65 mol % from domestic waste. Intrinsic viscosity, molecular weight and thermal degradation of the polymers accumulated in the cells grown in glucose, glucose with valerate and glucose with waste were compared.

  18. MAL Overexpression Leads to Disturbed Expression of Genes That Influence Cytoskeletal Organization and Differentiation of Schwann Cells

    Directory of Open Access Journals (Sweden)

    Daniela Schmid

    2014-09-01

    Full Text Available In the developing peripheral nervous system, a coordinated reciprocal signaling between Schwann cells and axons is crucial for accurate myelination. The myelin and lymphocyte protein MAL is a component of lipid rafts that is important for targeting proteins and lipids to distinct domains. MAL overexpression impedes peripheral myelinogenesis, which is evident by a delayed onset of myelination and reduced expression of the myelin protein zero (Mpz/P0 and the low-affinity neurotrophin receptor p75NTR . This study shows that MAL overexpression leads to a significant reduction of Mpz and p75NTR expression in primary mouse Schwann cell cultures, which was already evident before differentiation, implicating an effect of MAL in early Schwann cell development. Their transcription was robustly reduced, despite normal expression of essential transcription factors and receptors. Further, the cAMP response element-binding protein (CREB and phosphoinositide 3-kinase signaling pathways important for Schwann cell differentiation were correctly induced, highlighting that other so far unknown rate limiting factors do exist. We identified novel genes expressed by Schwann cells in a MAL-dependent manner in vivo and in vitro. A number of those, including S100a4, RhoU and Krt23, are implicated in cytoskeletal organization and plasma membrane dynamics. We showed that S100a4 is predominantly expressed by nonmyelinating Schwann cells, whereas RhoU was localized within myelin membranes, and Krt23 was detected in nonmyelinating as well as in myelinating Schwann cells. Their differential expression during early peripheral nerve development further underlines their possible role in influencing Schwann cell differentiation and myelination.

  19. El mal de ojo y su relación con el marasmo y kwashiorkor: El caso de las madres de Turbo, Antioquia, Colombia Mal de ojo and its relationship with marasm and kwashiorkor: the Turbo mother’s case

    Directory of Open Access Journals (Sweden)

    Gildardo Uribe Gil

    2007-03-01

    Full Text Available Objetivo: Describir las percepciones y prácticas socio-culturales de las madres frente al proceso de desnutrición aguda grave de los niños: marasmo y kwashiorkor. Metodología: Etnografía descriptiva. Se realizaron 20 entrevistas semiestructuradas, 2 entrevistas grupales y observación en los hogares y en el hospital. El análisis se realizó manualmente. Resultados: Las madres perciben la desnutrición aguda grave como una consecuencia del mal de ojo, el cual afecta a los niños menores de 7 años. El mal de ojo se clasifica como "ojo secador" y "ojo de la calle". Para las madres, el ojo secador enmagrece totalmente a los niños, lo cual podríamos asimilar al marasmo. No es claro si el ojo de la calle conlleva al kwashiorkor, pero es claro que el kwashirkor es causado por el mal de ojo. Los médicos tradicionales, como los rezanderos, ocupan un lugar importante en el tratamiento de las enfermedades de filiación cultural. Conclusiones: En el modelo biomédico no existen ni el mal de ojo ni la desnutrición como enfermedad. La desnutrición se conceptúa como estado y finalmente se objetiviza en cifras estadísticas, lo cual dificulta la atención integral de los niños. El estudio devela un mundo desconocido por el sistema biomédico, y un mundo de prácticas culturales frente al proceso de desnutrición, que adecuadamente valoradas permitirían mejorar la atención integral y evitar la muerte infantil por desnutrición aguda grave o por el mal de ojo.Objective: To describe perceptions and socio- cultural practices by the mothers facing severe malnutrition in children: Marasm and Kwashiorkor. Methodology: Descriptive ethnography. Twenty semi-structured interviews and two tribal ones were carried. Homes and hospitalized children were observed. Analysis was manually performed. Results: Mother perceives severe malnutrition like "mal de ojo" consequence afflicting children under seven. Mal de ojo is classified as "drying-eye" or as "street

  20. Malária grave importada: relato de caso Severe imported malaria: case report

    Directory of Open Access Journals (Sweden)

    Alessandra Alves

    2007-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A malária ainda representa um problema de saúde global. A forma grave da doença é causada principalmente por P. falciparum e pode cursar com complicações cerebrais, renais, pulmonares, hematológicas, circulatórias e hepáticas. O objetivo deste estudo foi relatar um caso de paciente portador de malária grave importada. RELATO DO CASO: Paciente do sexo masculino, 30 anos, pardo, filipino, marinheiro, proveniente de embarcação vinda da Nigéria, com história de dor abdominal no hipocôndrio direito, icterícia, febre e rebaixamento do nível de consciência. Os exames laboratoriais de admissão mostraram hiperbilirrubinemia de 50 mg/dL, acidose metabólica grave, trombocitopenia, creatinina de 5,6 mg/dL, leucocitose com desvio até metamielócitos. O escore APACHE II foi de 37, com risco de óbito de 88%. Durante a internação foi diagnosticada malária por P. falciparum pelo teste de gota espessa. Mesmo com tratamento antimalárico adequado, o paciente evoluiu com insuficiência renal aguda necessitando de hemodiálise e síndrome de angústia respiratória aguda (SARA, necessitando de ventilação mecânica (VM, choque refratário tratado com aminas vasoativas, além de quadro hematológico, configurando um caso grave de disfunção de múltiplos de órgãos. Ainda apresentou pneumonia associada à VM e sepse relacionada ao uso de cateteres. Após a alta hospitalar, o paciente não apresentou seqüelas cerebral, pulmonar ou renal. CONCLUSÕES: Dos critérios definidores de malária grave descritos na literatura, o paciente preenchia: insuficiência renal aguda, síndrome da angústia respiratória aguda (SARA, acidose metabólica, alteração do nível de consciência, hemoglobinúria macroscópica, hiperparasitemia e hiperbilirrubinemia, que se relaciona a uma mortalidade maior que 10%, na dependência do tratamento precoce e dos recursos disponíveis. A malária grave exige diagnóstico e tratamento

  1. Le problème du mal dans le Guide des Perplexes et son arrière-plan talmudique

    Directory of Open Access Journals (Sweden)

    Costa, José

    2010-12-01

    Full Text Available At first sight, the question of evil is regarded in the Guide for the Perplexed in a paradoxical manner. Thus, in Guide I, 2, Maimonides examines the notions of good and evil as subjective evaluations possessing neither the rigour not the exactness of the notions of true and false. However, the question of evil occupies an essential place in the Guide, as various modern authors have shown. This question is important to Maimonides because he is, in this respect, the heir of the rabbinic tradition and his conception of evil is largely based on an interaction with the Talmudic and Midrašic texts. Therefore, we would like to review thirty-nine rabbinic ‘quotes’ which appear in chapters 8 to 24 in the third part of the Guide and deal with the origin of evil, the meaning of suffering and the evil inclination. Maimonides reappropriates the midrašim that are susceptible of being in agreement with his rationalist positions and also quotes some rabbinic traditions that are too close to mu ͑tazilism, undoubtedly aware of the more profound resemblance that exists between the rabbinic and mu ͑tazilite doctrines of evil and retribution.A primera vista, el problema del mal es abordado en la Guía de Perplejos de manera paradójica. Para Maimónides, las nociones de bien y mal son subjetivas y no resultan ni rigorosas ni exactas, a la inversa de las nociones de verdad y falsedad (Guía I, 2. Sin embargo, el problema del mal es muy importante en la Guía, como lo demostraran varios autores. Maimónides es el heredero de la tradición rabínica y existe en la Guía una interacción entre la filosofia de Maimónides y los textos talmúdicos y midrásicos. Es particularmente el caso de las treinta y nueve citas rabínicas de la Guía II, 8-24, que tratan del origen del mal, del significado del sufrimiento y de la inclinación al mal. Maimónides cita los midrašim que concuerdan con sus posiciones racionalistas y evoca también algunas tradiciones rab

  2. Epilepsia"Petit Mal" aspectos clínicos, eletrencefalográficos e evolutivos

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    Paulo Pinto Pupo

    1961-01-01

    Full Text Available In the past few years somewhat new yet often differing points of view have been affirmed refering to Petit Mal epilepsy, with regard to its clinical, eletrencephalographic and evolutive aspects. The classical concept of PM epilepsy as established by Lennox and Gibbs, with its well defined clinical and EEGraphic characteristics is continually being modified with new research work on clinical and EEGraphic aspects. Numerous clinical cases have been published whose evolution clashes with that classically described and likewise numerous are those cases where the EEG shows signs of focal electric activity besides spike and wave dis-rythmia. Cases have been known where surgical exerese on the focus causes temporary desappearance of the spike and wave disrythmia. The present concept now holding sway is that PM epilepsy is a kind of reaction of infantile encephalon to diverse harmful causes. From this it will be seen we are very far from the concept that PM epilepsy is a pure form of idiopathic epilepsy. For these reasons we decided to re-examine those cases observed between 1950 and 1960. With this in mind we chose 141 PM epilepsy cases, from among over 23000 epileptics, all examined under a standard criterion by a small group of senior assistants. All cases suspected of Psm epilepsy were excluded. The analysis of this group of patients was compared to that of another group with GM as well as PM seizures (104 patients; in 52 of these cases, studies were made concerning the evolutive, clinical and EEGra-phic aspects. METHOD: Clinical criterion was used for selection of the cases. The results of the analysis from the clinical and EEGraphic point of view were exhibited in demonstrative graphs. From the clinical point of view we strove to find out positive hereditary elements, organic cerebral injury factor (intellectual deficit, mood and behaviour disturbances, neurologic or somatic signs, as well as other development anomalies, the presence of febrile

  3. Hypothesis: The Vestibular and Cerebellar Basis of the Mal de Debarquement Syndrome

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    Bernard Cohen

    2018-02-01

    Full Text Available The Mal de Debarquement syndrome (MdDS generally follows sea voyages, but it can occur after turbulent flights or spontaneously. The primary features are objective or perceived continuous rocking, swaying, and/or bobbing at 0.2 Hz after sea voyages or 0.3 Hz after flights. The oscillations can continue for months or years and are immensely disturbing. Associated symptoms appear to be secondary to the incessant sensation of movement. We previously suggested that the illness can be attributed to maladaptation of the velocity storage integrator in the vestibular system, but the actual neural mechanisms driving the MdDS are unknown. Here, based on experiments in subhuman primates, we propose a series of postulates through which the MdDS is generated: (1 The MdDS is produced in the velocity storage integrator by activation of vestibular-only (VO neurons on either side of the brainstem that are oscillating back and forth at 0.2 or 0.3 Hz. (2 The groups of VO neurons are driven by signals that originate in Purkinje cells in the cerebellar nodulus. (3 Prolonged exposure to roll, either on the sea or in the air, conditions the roll-related neurons in the nodulus. (4 The prolonged exposure causes a shift of the pitch orientation vector from its original position aligned with gravity to a position tilted in roll. (5 Successful treatment involves exposure to a full-field optokinetic stimulus rotating around the spatial vertical countering the direction of the vestibular imbalance. This is done while rolling the head at the frequency of the perceived rocking, swaying, or bobbing. We also note experiments that could be used to verify these postulates, as well as considering potential flaws in the logic. Important unanswered questions: (1 Why does the MdDS predominantly affect women? (2 What aspect of roll causes the prolongation of the tilted orientation vector, and why is it so prolonged in some individuals? (3 What produces the increase in symptoms of

  4. Migrações internas e malária urbana - Bahia, Brasil Internal migration and urban malaria - Bahia, Brazil

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    Sebastião Loureiro de Souza

    1986-10-01

    Full Text Available Estuda-se as características sócio-econômicas dos indivíduos acometidos pela malária, em 1983, na área urbana de Camaçari - Bahia, Brasil, com destaque para os subgrupos migrantes e não migrantes. As condições de vida precárias de ambos os subgrupos são apontadas como os determinantes do surto de malária desencadeado no local.It is proposed to study the socio-economic characteristics of individuals who were infected with malaria in the urban area of Camaçari, Bahia, Brazil, in 1983. Special emphasis being given to the subgroups of migrants and nonmigrants. The precarious living conditions of both subgroups are identified as determinative of the malaria outbreak which occurred there.

  5. Analytical Characterization of the Hydrolysis of Barley Malt Macromolecules During Enzymatic Degradation Over Time Using AF4/MALS/RI.

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    Rübsam, Heinrich; Becker, Thomas; Gastl, Martina

    2017-06-01

    The changes on the molecular weight distribution (MWD) and particle size distribution (PSD) during hydrolysis of barley malt in isothermal mashing procedures were determined using asymmetrical flow field flow fractionation coupled to multiangle laser light scattering and refractive index (AF4/MALS/RI). Mash/trials were focused on amylolytic starch degradation. Therefore, temperatures (65, 70, and 75 °C) were selected according to α- and β-amylases range of activity. Samples were produced by triplicate, tracking amylolytic processes over time periods from 10 to 90 min in each mash/trial. AF4/MALS/RI analysis demonstrated significant differences on the values of the MWD and PSD according to the temperature/time profile used. At mashing times over 30 min at a temperature of 65 °C, when α- and β-amylase are both active, the decrease over time of the MWD and PSD was significantly higher (P < 0.005) than at 70 °C when mainly α-amylase is active. At 75 °C, also the activity of α-amylase decreased and the MWD and PSD were significantly lower (P < 0.005) than at 70 or 65 °C at any time of the procedure. The MWD and PSD of beer components influence beer palate fullness, thus AF4/ MALS/RI would be a powerful tool for breweries to adapt their technological processes to obtain beers with particular sensorial attributes. © 2017 Institute of Food Technologists®.

  6. La naturaleza del mal en el pensamiento de Hannah Arendt | The nature of evil in Hannah Arendt’s thinking

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    María Cristina Hermida del Llano

    2016-12-01

    Full Text Available RESUMEN. La cuestión del mal ocupa un lugar central en el pensamiento de Hannah Arendt al constituir un concepto transversal que recorre todos sus trenes de pensamiento. Se somete a análisis la “naturaleza del mal” a través del estudio de su obra y de su propia experiencia vital, especialmente al cubrir el juicio de Eichmann en Jerusalén, donde ella afirmaría que éste representaba “la banalidad del mal”. Se trata de averiguar si en su particular concepción del mal influyó Voltaire, por qué surge el mal, por qué se manifiesta de forma permanente en la historia y si puede ser destruido   ABSTRACT. The topic of evil has a central place in Hannah Arendt’s thinking as it lies at the core of all her trains of thought. We analyze the “nature of evil” in Hannah Arendt’s philosophy through the study of her work and of her life experience, especially when she covered the trial of Eichmann in Jerusalem where she pointed out that Eichmann represented “the banality of evil”. Our goal in this contribution is to understand whether the philosophy of Voltaire could have influenced Arendt’s conception of evil, why it arises, why it persists throughout history, and whether it can be destroyed

  7. Recombinant Mal d 1 facilitates sublingual challenge tests of birch pollen-allergic patients with apple allergy.

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    Kinaciyan, T; Nagl, B; Faustmann, S; Kopp, S; Wolkersdorfer, M; Bohle, B

    2016-02-01

    It is still unclear whether allergen-specific immunotherapy (AIT) with birch pollen improves birch pollen-related food allergy. One reason for this may be the lack of standardized tests to assess clinical reactions to birch pollen-related foods, for example apple. We tested the applicability of recombinant (r) Mal d 1, the Bet v 1-homolog in apple, for oral challenge tests. Increasing concentrations of rMal d 1 in 0.9% NaCl were sublingually administered to 72 birch pollen-allergic patients with apple allergy. The dose of 1.6 μg induced oral allergy syndromes in 26.4%, 3.2 μg in 15.3%, 6.3 μg in 27.8%, 12.5 μg in 8.3%, 25 μg in 11.1%, and 50 μg in 4.2% of the patients. No severe reactions occurred. None of the patients reacted to 0.9% NaCl alone. Sublingual administration of 50 μg of rMal d 1 induced no reactions in three nonallergic individuals. Our approach allows straight forward, dose-defined sublingual challenge tests in a high number of birch pollen-allergic patients that inter alia can be applied to evaluate the therapeutic efficacy of birch pollen AIT on birch pollen-related food allergy. © 2015 The Authors. Allergy Published by John Wiley & Sons Ltd.

  8. Albertet, “En amor trob tantz de mals seignoratges” (BdT 16.13

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    Francesca Sanguineti

    2008-12-01

    Full Text Available The article provides a commentary and a new critical edition of Albertet’s poem “En amor trob tantz de mals seignoratges”, in which the troubadour praises some of the most courtly ladies of his time. The poem can be linked to the genre of the collective eulogy, where the enumerated ladies are praised essentially for political reasons, since the commendation is clearly addressed to the men hidden behind them: famous specimena of this genre are the ‘tournoiements des dames’ by Huon d’Oisy and Richard de Semilli and Raimbaut de Vaqueiras’ “Carros” (BdT 392.32. Albertet’s song starts with a misogynic tone, since the poet declares that celebrating or loving ladies is worthless, given their immoral behaviour, and with a polemic against the strict rules of courtly love. This misogyny, as is further discovered, is a rhetorical device to praise women as well as a tool to renew the genre of the love song from a thematic point of view.

  9. (Mal)nutrition and the new epidemiological trend in a context of development and inequalities.

    Science.gov (United States)

    Souza, Nathália Paula de; Lira, Pedro Israel Cabral de; Fontbonne, Annick; Pinto, Fernanda Cristina de Lima; Cesse, Eduarda Ângela Pessoa

    2017-07-01

    The current context of intense social, economic and political transformations has contributed to changes in the health profile of the population and generated discussions about the impact of these changes on the reorganization of society. At the present moment, the increase in non-communicable illnesses and diseases raises major concerns about the paradox of malnutrition and obesity. Based on an in-depth reading and interpretation of texts, documents and databases, this article discusses issues related to nutrition, considering the dimensions of shortages and excesses, the evolution of nutrition over time, and the connection with the new epidemiological trend. We begin with a conceptual characterization, the historical background and the anthropological connections with the guiding theme of the article. We then describe the prevalence, distribution and secular trend of malnutrition and obesity, as well as the temporal relationship with the new epidemiological trend in Brazil within a context of development and inequalities. Finally, we reflect on the issue of (mal)nutrition in post-modernity, the new interests at stake in the health-disease process, as well as international experiences and strategies of partnerships designed to overcome these problems. We conclude by discussing some current advances and challenges in relation to the complexity and speed of contemporary changes.

  10. Decodificando la esencia del mal, o del terror a la muerte del hijo

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    Maximiliano Korstanje

    2011-01-01

    Full Text Available Durante muchos años filósofos y teólogos se han cuestionado sobre la cuestión de la caída. Es innumerable la bibliografía sobre el tema como así también las propias dudas sobre la omnipresencia y sabiduría de un Dios que implícitamente o no permite la presencia del pecado por medio de su propia creación. El mito fundador de querubín Lucifer no sólo simboliza la relación entre el hombre y la traición sino también el amor filial entre el padre y su creación las cuales concilian la negación cultural de la muerte de la progenie o generaciones más jóvenes. Utilizando la teoría antropológica de los dones de M. Mauss, el presente trabajo teórico intentará explicar el origen mítico del mal dentro de la tradición judeo-cristiana como una de las elaboraciones más temidas, la muerte del hijo.

  11. Quema de libros y antitotalitarismo. Manuel Rivas Los libros arden mal y Ray Bradbury Fahrenheit 451

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    Mechthild Albert

    2015-07-01

    Full Text Available El presente artículo se propone comparar dos novelas cuyo común denominador es el compromiso antitotalitario con motivo de la quema de libros considerada como el culmen de la barbarie anticultural, a saber Los libros arden mal (2006 de Manuel Rivas y Fahrenheit 451 (1953 de Ray Bradbury. Partiendo de las reflexiones de Fernando Rodríguez de la Flor en torno al biblioclasmo (2004, el paralelo se centra en los siguientes aspectos: la descripción zoo- y antropomorfizada de los libros en llamas; el biblioclasmo como expresión del totalitarismo, denotando asimismo una relación ambivalente y dialéctica entre cultura y barbarie; los movimientos subversivos dedicados a mantener el culto al libro y la tradición filosófico-literaria; la intertextualidad y el papel destacado de la Biblia en cuanto Libro de los libros. En conclusión se podrá constatar que, a pesar de numerosos puntos en común, en particular su compromiso antitotalitario, ambos autores se distinguen en concreto por su orientación política y el enfoque de su crítica cultural

  12. El mal en las palabras: El hombre tempestad Evil in Words: El hombre tempestad

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    Ángela Uribe Botero

    2009-06-01

    Full Text Available En este trabajo se muestra cómo es posible que el mal pueda estar contenido en cierta forma de hablar. En términos de J. L. Austin, y de la mano de Hannah Arendt, a la luz de un ejemplo tomado de la historia colombiana, se ilustra la fuerza ilocucionaria de ciertas expresiones. El ejemplo está contenido en uno de los discursos más célebres del expresidente colombiano Laureano Gómez Castro. El texto concluye mostrando cómo, con los enunciados que Gómez emite, antes que cumplir las promesas que hace en su discurso o describir una serie de cosas, miente y en tanto hace esto, cambia el mundo en la forma de actuar sobre él con maldad.This text shows how evil can be contained in certain way of speaking. In terms of J. L. Austin, and considering Hannah Arendt, with the help of an example taken from recent Colombian history, it illustrates the ilocucionary force of certain expressions. The example is found in one of the most important speeches of former president Laureano Gómez Castro. The text concludes by showing how, Gómez, rather than maintaining promises that he makes in his speech or describing a series of things, lies, and in so doing, changes the world through his way of evilly acting above it.

  13. Santa Clara de Nanay: the MAL-ED cohort in Peru.

    Science.gov (United States)

    Yori, Pablo Peñataro; Lee, Gwenyth; Olórtegui, Maribel Paredes; Chávez, César Banda; Flores, Julian Torres; Vasquez, Angel Orbe; Burga, Rosa; Pinedo, Silvia Rengifo; Asayag, César Ramal; Black, Robert E; Caulfield, Laura E; Kosek, Margaret

    2014-11-01

    The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study communities in Peru are located in Loreto province, in a rural area 15 km from the city of Iquitos. This riverine population of approximately 5000 individuals is fairly representative of Loreto. The province lags behind the rest of the country in access to water and sanitation, per capita income, and key health indicators including infant mortality (43.0 vs 16.0 per 1000 nationwide) and under-5 mortality (60.6 vs 21.0 per 1000). Total fertility rates are higher than elsewhere in the country (4.3 vs 2.6). Nationwide, the prevalence of human immunodeficiency virus is estimated at 0.45%, the prevalence of tuberculosis is 117 per 100 000, and the incidence of malaria is 258 per 100 000. Stunting in this community is high, whereas acute undernutrition is relatively uncommon. The population suffers from high rates of diarrheal disease. Prevalent enteric pathogens include Ascaris, Giardia, enterotoxigenic Escherichia coli, Shigella, and Campylobacter. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  14. Simulação no contexto de problemas mal estruturados

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    Antônio Sérgio de Souza

    1994-12-01

    Full Text Available Simulação é atualmente reconhecida como uma poderosa ferramenta no projeto, análise e operação de sistemas produtivos. Apesar dos avanços recentes em linguagens de simulação, interfaces gráficas e geradores de aplicações, simulação ainda é uma técnica cara e pouco eficiente. Discute-se no texto algumas causas deste fato no contexto de problemas mal estruturados, como é o caso de planejamento e controle da produção. Discute-se a necessidade de realização da modelagem conceitual, não apenas como um passo estanque no processo de simulação, mas de forma progressiva e dinâmica, durante todo o ciclo de vida do projeto, servindo como uma interface entre os contextos real e de simulação.Simulation is now recognized as powerful tool in project, analyses and operation of produtive systems. Although the recent advances in simulation languages, graphical interfaces and in generating applications, simulation is still an expensive and not so efficient technique. In this text we dicuss some reasons for this in the context of not well strutured problems, asit is the case of production planning and control. It is also dicussed the necessity of developing the conceptual modeling of the real system, not only as a separated step in the simulation process, but in a progressive and dynamic way, during the project's life cycle as an interface between the real system and simulation.

  15. Effect of play therapy on behavioral problems of mal-adjusted pre-school children

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    Mehdi Khanbani

    2011-01-01

    Full Text Available Objective: The present research was conducted to study the effect of play therapy on reducing behavioral problems of mal-adjusted children (children with oppositional defiant disorder. Method: By using multistage cluster sampling, regions 6, 7, and 8 in Tehran were selected, and among kindergartens of these areas, 3 kindergartens under the support of welfare organization were randomly selected. From pre-school children of these 3 kindergartens, 40 children that could have behavioral disorder according to their teachers and parents complaints, were carefully tested, and among them, by the results obtained from child symptom inventory questionnaire (CSI-4, teacher's form, and a researcher-made self-control checklist, 16 children who showed severe symptoms of oppositional defiant disorder were selected, and they were randomly divided into control and experimental group. This research is quasi-experimental, and is done by the use of pre-test, post-test, and control group. Results: values of calculated F for oppositional defiant disorder in control and experimental group is meaningful after fixing the effect of pre-test (F(1,12=74/94, P<0/001 so there is a meaningful difference between means of disobedience disorder post-test scores in experimental and control group by having the fixed effect of pre-test effect. Comparison of adjusted means of 2 groups shows that the mean of attention-deficit hyperactivity disorder (ADHD in experimental group (M=14/09 is lower than control group (M=36/66. Therefore, applying play therapy in experimental group in comparison with control group, who did not receive these instructions, caused reduction in attention-deficit hyperactivity disorder (ADHD in pre-school children. Conclusion: Results of this research show that the children's disobedience is reduced by benefiting from play therapy.

  16. Comparison of measles complications in well nourished and mal-nourished children

    International Nuclear Information System (INIS)

    Qaisar, I.; Ahmad, A.; Ahmad, A.

    2009-01-01

    Measles is the most common and the most infectious of the viral infections of childhood. It can cause severe pneumonia, diarrhoea, encephalitis, and death. A significant proportion of deaths due to measles in young children worldwide are attributable to low weight for age. To compare the measles complications in well-nourished and mal-nourished children, this cross-sectional study was conducted at Paediatric out-patient department and paediatric unit 1 Bahawal Victoria Hospital Bahawalpur. Total 120 patients were included in the study. All patients presented with signs and symptoms suggestive of measles according to WHO criteria. These patients were divided into well nourished and malnourished according to the modified Gomez classification. Both groups were evaluated for measles complications like pneumonia, diarrhoea, encephalitis, corneal ulceration, thrombocytopenia, otitis media and myocarditis by detailed history and complete physical examination, and statistically analysed. In the studied patients, 75 were males and 45 were females. Mean age was 23 months. Fifty-nine (49.2%) patients were well-nourished and 61 (50.8%) were undernourished. Fifty-two (43.3%) patients were having pneumonia. Fifty-three (44.2%) patients were having diarrhoea. Twenty-six (21.7%) patients were having encephalitis. Corneal ulceration was found in 9 (7.5%) patients. Thrombocytopenia and otitis media was present in 1 patient in each group. Fourteen patients expired. Measles is a global epidemic problem having many serious complications, including pneumonia, diarrhoea, encephalitis, corneal ulcerations etc. Moreover these complications are more frequent in under nourished children. Efforts should be made to improve the nutritional status of the children and to eradicate this disease by effective vaccination. (author)

  17. Early childhood growth and cognitive outcomes: Findings from the MAL-ED study.

    Science.gov (United States)

    Scharf, Rebecca J; Rogawski, Elizabeth T; Murray-Kolb, Laura E; Maphula, Angelina; Svensen, Erling; Tofail, Fahmida; Rasheed, Muneera; Abreu, Claudia; Vasquez, Angel Orbe; Shrestha, Rita; Pendergast, Laura; Mduma, Estomih; Koshy, Beena; Conaway, Mark R; Platts-Mills, James A; Guerrant, Richard L; DeBoer, Mark D

    2018-02-02

    Although many studies around the world hope to measure or improve developmental progress in children to promote community flourishing and productivity, growth is sometimes used as a surrogate because cognitive skills are more difficult to measure. Our objective was to assess how childhood measures of anthropometry correlate with measures of child development in low-income settings with high prevalence of poor nutrition and enteric disease, to inform studies considering growth outcomes in the absence of direct child developmental skill assessment. Children from the MAL-ED study were followed from birth to 24 months of age in field sites in 8 low- and middle-income countries across 3 continents. Monthly weight, length, and head circumference measurements were performed. At 24 months, the Bayley Scales of Infant and Toddler Development was administered. We correlated cognitive measures at 24 months with anthropometric measurements from birth to 2 years comparing 3 constructs: absolute attained monthly measures, summative difference in measures from the mean growth curve, and rate of change in measures. Growth faltering at multiple time periods is related to Bayley cognitive outcomes at 24 months. Birthweight, overall growth by 18-24 months, and rate of growth in the 6- to 18-month period were most associated with 24-month developmental scores. In this study, head circumference measurements, compared with length, was more closely linked to cognitive scores at 24 months. Notably, all studies between growth and cognitive outcomes exhibited low r 2 values (0.001-0.049). Anthropometric measures, particularly head circumference, were related to cognitive development, although explaining a low percent of variance. When feasible, direct measures of child development may be more useful. © 2018 John Wiley & Sons Ltd.

  18. MalHaploFreq: A computer programme for estimating malaria haplotype frequencies from blood samples

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    Smith Thomas A

    2008-07-01

    Full Text Available Abstract Background Molecular markers, particularly those associated with drug resistance, are important surveillance tools that can inform policy choice. People infected with falciparum malaria often contain several genetically-distinct clones of the parasite; genotyping the patients' blood reveals whether or not the marker is present (i.e. its prevalence, but does not reveal its frequency. For example a person with four malaria clones may contain both mutant and wildtype forms of a marker but it is not possible to distinguish the relative frequencies of the mutant and wildtypes i.e. 1:3, 2:2 or 3:1. Methods An appropriate method for obtaining frequencies from prevalence data is by Maximum Likelihood analysis. A computer programme has been developed that allows the frequency of markers, and haplotypes defined by up to three codons, to be estimated from blood phenotype data. Results The programme has been fully documented [see Additional File 1] and provided with a user-friendly interface suitable for large scale analyses. It returns accurate frequencies and 95% confidence intervals from simulated dataset sets and has been extensively tested on field data sets. Additional File 1 User manual for MalHaploFreq. Click here for file Conclusion The programme is included [see Additional File 2] and/or may be freely downloaded from 1. It can then be used to extract molecular marker and haplotype frequencies from their prevalence in human blood samples. This should enhance the use of frequency data to inform antimalarial drug policy choice. Additional File 2 executable programme compiled for use on DOS or windows Click here for file

  19. Comprometimento pulmonar na malária (revisão Pulmonary involvement in malaria

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    Marcos Boulos

    1993-02-01

    Full Text Available Com uma incidência de 3 a 10% dos casos e letalidade próxima a 70%, o comprometimento pulmonar constitui uma das manifestações mais graves da malária por Plasmodium falciparum. Embora sua patogênese não esteja perfeitamente esclarecida, reconhece-se que a hiperativação do sistema imune por antígenos liberados pelo Plasmodium falciparum desempenhe um importante papel no desencadeamento e agravamento das lesões. A estrutura alvo parece ser o endotélio capilar, responsável pelo fluxo de líquidos para o espaço intersticial. Essas células são ativadas por ação de citocinas, produzidas por linfócitos e macrófagos durante a resposta imune, e passam a expressar em sua membrana celular receptores e moléculas de aderência que facilitam a sequestração de eritrócitos parasitados e também a aderência de células capazes de produzir mediadores inflamatórios. A reação inflamatória e a lesão endotelial que se seguem, juntamente com as alterações hemodinâmicas induzidas pelo bloqueio capilar devido ao acúmulo local de eritrócitos e células inflamatórias causam alterações de permeabilidade vascular e, consequentemente, acúmulo de líquido nos espaços intersticiais e alvéolos. Nos casos mais graves, as manifestações clínicas assemelham-se às do quadro da Síndrome do desconforto respiratório do adulto. Comprometimento pulmonar grave pode se instalar rapidamente em qualquer estágio da evolução clínica da malária, mesmo após a cura parasitológica, desconhecendo-se os fatores desencadeantes. Hiperparasitismo, insuficiência renal e gravidez constituem fatores predisponentes. O prognóstico dependerá da rapidez com que o diagnóstico for estabelecido e o correto tratamento instituído. Além do tratamento instituído contra o parasita, especial atenção deverá ser dispensada à monitorização hemodinâmica, se possível através de cateter de Swan-Ganz, à manutenção de adequada oxigenação e balanço h

  20. Isolation of Mal d 1 and Api g 1 - specific recombinant antibodies from mouse IgG Fab fragment libraries - Mal d 1-specific antibody exhibits cross-reactivity against Bet v 1.

    Science.gov (United States)

    Haka, Jaana; Niemi, Merja H; Iljin, Kristiina; Reddy, Vanga Siva; Takkinen, Kristiina; Laukkanen, Marja-Leena

    2015-05-27

    Around 3-5% of the population suffer from IgE-mediated food allergies in Western countries and the number of food-allergenic people is increasing. Individuals with certain pollen allergies may also suffer from a sensitisation to proteins in the food products. As an example a person sensitised to the major birch pollen allergen, Bet v 1, is often sensitised to its homologues, such as the major allergens of apple, Mal d 1, and celery, Api g 1, as well. Development of tools for the reliable, sensitive and quick detection of allergens present in various food products is essential for allergic persons to prevent the consumption of substances causing mild and even life-threatening immune responses. The use of monoclonal antibodies would ensure the specific detection of the harmful food content for a sensitised person. Mouse IgG antibody libraries were constructed from immunised mice and specific recombinant antibodies for Mal d 1 and Api g 1 were isolated from the libraries by phage display. More detailed characterisation of the resulting antibodies was carried out using ELISA, SPR experiments and immunoprecipitation assays. The allergen-specific Fab fragments exhibited high affinity towards the target recombinant allergens. Furthermore, the Fab fragments also recognised native allergens from natural sources. Interestingly, isolated Mal d 1-specific antibody bound also to Bet v 1, the main allergen eliciting the cross-reactivity syndrome between the birch pollen and apple. Despite the similarities in Api g 1 and Bet v 1 tertiary structures, the isolated Api g 1-specific antibodies showed no cross-reactivity to Bet v 1. Here, high-affinity allergen-specific recombinant antibodies were isolated with interesting binding properties. With further development, these antibodies can be utilised as tools for the specific and reliable detection of allergens from different consumable products. This study gives new preliminary insights to elucidate the mechanism behind the pollen

  1. Brucella TIR-like protein TcpB/Btp1 specifically targets the host adaptor protein MAL/TIRAP to promote infection.

    Science.gov (United States)

    Li, Wenna; Ke, Yuehua; Wang, Yufei; Yang, Mingjuan; Gao, Junguang; Zhan, Shaoxia; Xinying, Du; Huang, Liuyu; Li, Wenfeng; Chen, Zeliang; Li, Juan

    2016-08-26

    Brucella spp. are known to avoid host immune recognition and weaken the immune response to infection. Brucella like accomplish this by employing two clever strategies, called the stealth strategy and hijacking strategy. The TIR domain-containing protein (TcpB/Btp1) of Brucella melitensis is thought to be involved in inhibiting host NF-κB activation by binding to adaptors downstream of Toll-like receptors. However, of the five TIR domain-containing adaptors conserved in mammals, whether MyD88 or MAL, even other three adaptors, are specifically targeted by TcpB has not been identified. Here, we confirmed the effect of TcpB on B.melitensis virulence in mice and found that TcpB selectively targets MAL. By using siRNA against MAL, we found that TcpB from B.melitensis is involved in intracellular survival and that MAL affects intracellular replication of B.melitensis. Our results confirm that TcpB specifically targets MAL/TIRAP to disrupt downstream signaling pathways and promote intra-host survival of Brucella spp. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Situação da malária na tríplice fronteira entre Brasil, Colômbia e Peru

    Directory of Open Access Journals (Sweden)

    Paulo César Peiter

    2013-12-01

    Full Text Available O objetivo deste artigo é analisar a situação da vigilância da malária na tríplice fronteira entre Brasil, Colômbia e Peru. É um estudo qualitativo com aplicação de questionários em cidades da fronteira realizado em 2011. Os resultados foram analisados pela metodologia DOFA e apontaram diferenças significativas entre os sistemas de vigilância da malária na fronteira. Observou-se como debilidades a desarticulação entre atores responsáveis, a insuficiência de pessoal treinado, a alta rotatividade das equipes e a falta de médicos especialistas em malária nos hospitais locais. Verificou-se ainda o desconhecimento sobre a malária e suas formas de prevenção na população entrevistada. As fortalezas são a inserção de novos atores institucionais, a melhora da qualificação profissional, a distribuição de mosquiteiros impregnados e possibilidades de complementaridade entre os sistemas de vigilância a serem aproveitadas pela cooperação entre as equipes de saúde da fronteira, pois o controle da malária só pode ter sucesso tomando-se esta região em seu conjunto.

  3. A formação humana e a incapacidade de pensar: considerações sobre o problema do mal em Hannah Arendt

    Directory of Open Access Journals (Sweden)

    Marcos Alexandre Alves

    2017-08-01

    Full Text Available Este artigo pretende apresentar o tema da formação humana conectado à incapacidade de pensar, tecendo considerações sobre o problema do mal no pensamento de Hannah Arendt. A autora é conhecida como pensadora da política que concentrou atenção especial ao problema do mal que assolou o mundo na primeira metade do século XX. A partir da análise de Origens do Totalitarismo, de 1951, e de Eichmann em Jerusalém: um relato sobre a banalidade do mal, de 1963, pretende-se refletir acerca dos mecanismos que produzem o adormecimento da capacidade de pensar frente à necessidade da formação humana. A partir dessa análise, se perceberá que o problema do mal assume um viés radical, uma possibilidade de destruição completa do humano. Na análise do caso Eichmann, Arendt percebeu que o réu agia banalmente, manifestando sua incapacidade de pensar, o que tornou possível a normalização da insensibilidade frente o diferente. Portanto, a banalidade do mal implica na incapacidade de pensar, uma ameaça sempre constante à formação humana

  4. Malária pulmonar: aspectos na tomografia computadorizada de alta resolução - relato de caso

    Directory of Open Access Journals (Sweden)

    Rodrigues Rosana

    2004-01-01

    Full Text Available Neste trabalho é relatado o caso de paciente do sexo masculino, de 38 anos de idade, que desenvolveu quadro de malária com comprometimento pulmonar. A tomografia computadorizada de alta resolução evidenciou espessamento de septos interlobulares e de bainhas peribroncovasculares, com áreas esparsas de atenuação em vidro fosco e de consolidações, além de derrame pleural bilateral, aspectos compatíveis com edema pulmonar. O paciente recebeu tratamento específico, evoluindo bem e tendo alta 11 dias após a internação.

  5. Treatment of the Mal de Debarquement Syndrome: A 1-Year Follow-up

    Directory of Open Access Journals (Sweden)

    Mingjia Dai

    2017-05-01

    Full Text Available The mal de debarquement syndrome (MdDS is a movement disorder, occurring predominantly in women, is most often induced by passive transport on water or in the air (classic MdDS, or can occur spontaneously. MdDS likely originates in the vestibular system and is unfamiliar to many physicians. The first successful treatment was devised by Dai et al. (1, and over 330 MdDS patients have now been treated. Here, we report the outcomes of 141 patients (122 females and 19 males treated 1 year or more ago. We examine the patient’s rocking frequency, body drifting, and nystagmus. The patients are then treated according to these findings for 4–5 days. During treatment, patients’ heads were rolled while watching a rotating full-field visual surround (1. Their symptom severity after the initial treatment and at the follow-up was assessed using a subjective 10-point scale. Objective measures, taken before and at the end of the week of treatment, included static posturography. Significant improvement was a reduction in symptom severity by more than 50%. Objective measures were not possible during the follow-up because of the wide geographic distribution of the patients. The treatment group consisted of 120 classic and 21 spontaneous MdDS patients. The initial rate of significant improvement after a week of treatment was 78% in classic and 48% in spontaneous patients. One year later, significant improvement was maintained in 52% of classic and 48% of spontaneous subjects. There was complete remission of symptoms in 27% (32 of classic and 19% (4 of spontaneous patients. Although about half of them did not achieve a 50% improvement, most reported fewer and milder symptoms than before. The success of the treatment was generally inversely correlated with the duration of the MdDS symptoms and with the patients’ ages. Prolonged travel by air or car on the way home most likely contributed to the symptomatic reversion from the initial successful treatment

  6. Efeitos benéficos e maléficos da malva sylvestris

    Directory of Open Access Journals (Sweden)

    Ana Carolina Locatelli Ecker

    2016-04-01

    Full Text Available Objetivo. Revisar os efeitos benéficos e maléficos da Malva sylvestris para a saúde humana. Materiais e métodos. Foi realizada uma busca na base de dados BIREME, em setembro de 2014, por meio das pala­vras chaves malva AND sylvestris. Foram incluídos os artigos na língua inglesa e portuguesa sem limite de tempo. Foram excluídos os estudos repetidos e aqueles que não abordavam o tema. Resultados. Atra­vés da busca realizada, foram encontrados 56 artigos, destes, foram excluídos dois repetidos, um por encontrar-se no idioma chinês e, 41 por estarem fora do tema (benefícios para animais e solo, proprie­dades químicas da erva, pesquisa em campo de determinadas regiões do mundo abrangendo índices de utilização de muitas espécies de plantas para fins medicinais. Assim, foram, incluídos 12 artigos. Com grande importância terapêutica, a erva tem sido utilizada na área da saúde em geral para inflamações internas e externas, fins quimio-preventivos e antissépticos. Também alivia secreções como catarros, congestionamento das vias respiratórias e age como calmante no sistema neurológico. Segundo pes­quisas, o chá de malva apresenta resultados mais vantajosos do que tratamentos medicamentosos e é uma das mais utilizadas como auto-medicação. Conclusão. A Malva sylvestris é utilizada para muitos fins benéficos para o ser humano desde tempos remotos, mas sua comprovação científica tem ocorrido atualmente, evidenciando a veracidade de suas vantagens na saúde e no tratamento de patologias.

  7. EJERCICIO Y LA DETECCION DEL MAL AGUDO DE MONTAÑA GRAVE

    Science.gov (United States)

    Garófoli, Adrián; Montoya, Paola; Elías, Carlos; Benzo, Roberto

    2012-01-01

    El Mal Agudo de Montaña (MAM) es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral) pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2 700m y 4 300m en 63 sujetos que ascendían al cerro Aconcagua (6 962m). Se consideró desaturación de oxígeno con ejercicio a una disminución >=5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. 6 sujetos presentaron MAM grave (9.5%) y requirieron evacuación. La saturación de oxígeno en reposo a 2 700m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2 700m más la saturación inapropiada en reposo a 4 300m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave. PMID:20228017

  8. Securitización en el desierto: Una respuesta al terrorismo en Malí y en Níger, 2009 - 2013.

    OpenAIRE

    Guerrero Escobar, Laura Catalina

    2014-01-01

    Este es un estudio sobre las dinámicas de seguridad en Malí durante el periodo de 2009 a 2013. La investigación busca explicar de qué manera se ha dado un proceso de securitización de los grupos insurgentes frente a la amenaza generada por la proliferación de grupos armados no estatales en el territorio comprendido entre Malí y Níger. Se toma a Níger con el ánimo de ver la existencia de un subcomplejo regional de seguridad entre este país y Malí. De esta manera se afirma que el aumento de las...

  9. malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication

    Science.gov (United States)

    2017-01-01

    Basic science holds enormous power for revealing the biological mechanisms of disease and, in turn, paving the way toward new, effective interventions. Recognizing this power, the 2011 Research Agenda for Malaria Eradication included key priorities in fundamental research that, if attained, could help accelerate progress toward disease elimination and eradication. The Malaria Eradication Research Agenda (malERA) Consultative Panel on Basic Science and Enabling Technologies reviewed the progress, continuing challenges, and major opportunities for future research. The recommendations come from a literature of published and unpublished materials and the deliberations of the malERA Refresh Consultative Panel. These areas span multiple aspects of the Plasmodium life cycle in both the human host and the Anopheles vector and include critical, unanswered questions about parasite transmission, human infection in the liver, asexual-stage biology, and malaria persistence. We believe an integrated approach encompassing human immunology, parasitology, and entomology, and harnessing new and emerging biomedical technologies offers the best path toward addressing these questions and, ultimately, lowering the worldwide burden of malaria. PMID:29190277

  10. Fingerpainting am Touchscreen. Fünf Mal- und Zeichen-Apps für Android-Tablets

    Directory of Open Access Journals (Sweden)

    Christoph Kaindel

    2015-06-01

    Full Text Available Malen auf dem Touchscreen eines Smartphones oder Tablets ist eine natürliche und intuitive Tätigkeit; anders als bei der Nutzung eines Grafiktabletts am PC gibt es so gut wie keine Umstellungsphase. Christoph Kaindel hat für uns fünf Mal- und Zeichen-Apps unter die Lupe genommen. Bereits für Kinder ist in den diversen Appstores eine große Zahl an einfachen Mal-Apps zu finden, mit meist nur wenigen Einstellungsmöglichkeiten und oft fragwürdiger Qualität. Am anderen Ende des Spektrums liegt der professionelle Einsatz von Tablets im Grafikbereich, für den spezialisierte und entsprechend teure Geräte notwendig sind. Ich werde einige Apps aus dem Mittelfeld vorstellen, die sich für einfache wie anspruchsvolle Vorhaben und Projekte eignen, auch auf schwächeren Tablets laufen und preisgünstig oder gratis sind. Alle Apps bieten die Möglichkeit, unterwegs zu malen, zu skizzieren, Fotos zu verfremden und die entstandenen Bilder am PC weiter bearbeiten zu können. Für PCs gibt es einige empfehlenswerte kostenlose Malprogramme, die ich bereits in einem anderen Artikel (http://medienimpulse.at/articles/view/616 vorgestellt habe.

  11. Presencia de Anopheles (Nyssorhynchus benarrochi en áreas de selva con transmisión malárica

    Directory of Open Access Journals (Sweden)

    Roberto Fernández L

    2004-10-01

    Full Text Available Objetivos: Demostrar la presencia de An. (Nys. benarrochi en áreas de transmisión malárica, donde es frecuentemente identificado como An. evansae. Materiales y métodos: Se colectaron mosquitos en San José (Pucallpa, Muniches y Andoas (Alto Amazonas, localidades con transmisión de malaria. Con estos mosquitos se efectuaron crías biológicas en laboratorio con la finalidad de obtener material de estudio como son exuvias de larvas, pupas, adultos hembras y machos. Se efectuaron montajes de exuvias de larvas y pupas asociados con sus respectivos adultos, disecciones de las genitalias de machos y biometría de los adultos machos y hembras. Resultados: Además de las verificaciones efectuadas en el campo, basadas en el estudio de inmaduros y adultos, las crías biológicas efectuadas confirmaron la presencia de An. benarrochi en las localidades mencionadas. Asimismo, confirmaron también la existencia de gran variabilidad de los caracteres morfológicos externos, que pueden inducir al error en las identificaciones. Conclusiones: En las áreas maláricas estudiadas, la especie identificada como An. (Nys. evansae corresponde a An. (Nys. benarrochi, demostrado con nuestros estudios. Dada la variabilidad de caracteres que dificultan la identificación de las especies afines, es necesario realizar estudios completos con la finalidad de conocer la fauna local de anofelinos.

  12. A banalidade do mal e as possibilidades da educação moral: contribuições arendtianas

    Directory of Open Access Journals (Sweden)

    Marcelo Andrade

    2010-01-01

    Full Text Available Más que una época de crisis, enfrentamos hoy una crisis de época en la cual la educación desempeña un papel fundamental. En este sentido, el presente trabajo es una relectura de la obra de Hannah Arendt, filósofa que pensó y vivió en tiempos sombríos, con el fin de aclarar algunos conceptos que son fundamentales para que hoy pueda repensarse la educación moral o la educación en valores. A través de un estudio centrado en las obras Eichmann en Jerusalén: un estudio sobre la banalidad del mal y La vida del espíritu, este trabajo busca comprender cómo y por qué Hannah Arendt acuñó el concepto banalidad del mal y en qué sentido este se relaciona con el vacío del pensamiento y con una propuesta de educación en valores.

  13. Abuso de drogas e transtornos alimentares entre mulheres: sintomas de um mal-estar de gênero?

    Directory of Open Access Journals (Sweden)

    Regina Helena Simões-Barbosa

    Full Text Available Resumo: O artigo discute o abuso de drogas e os transtornos alimentares sob as perspectivas críticas de gênero e do cuidado em saúde. Postula-se que o sofrimento subjetivo pode se expressar no corpo por meio das doenças psicossomáticas. Nessa perspectiva, a insaciável fome consumista das drogas ou de bens supérfluos, bem como o adoecimento pela fome voluntária em busca de um ideal de esbeltez, como na anorexia e bulimia, podem ser sintomas que denunciam o sofrimento feminino. Uma revisão nos campos da saúde coletiva e das teorias feministas destaca a magnitude dos fenômenos da medicalização e mercantilização da saúde presentes na psiquiatrização do mal-estar feminino. Na transição de gênero das sociedades capitalistas, as cobranças sociais pelo desempenho dos velhos e novos papéis femininos acentuam sentimentos de inadequação, traduzidos no mal-estar de gênero que circunda o abuso de drogas e os transtornos alimentares, analisados como patologias de protesto. Propõe-se o resgate do ideário do Programa de Assistência Integral à Saúde da Mulher, orientado pela integralidade, para enfrentar tais desafios.

  14. First successful reduction of clinical allergenicity of food by genetic modification: Mal d 1-silenced apples cause fewer allergy symptoms than the wild-type cultivar

    DEFF Research Database (Denmark)

    Dubois, A. E. J.; Pagliarani, G.; Brouwer, R. M.

    2015-01-01

    BACKGROUND: Genetic modification of allergenic foods such as apple has the potential to reduce their clinical allergenicity, but this has never been studied by oral challenges in allergic individuals. METHODS: We performed oral food challenges in 21 apple-allergic individuals with Elstar apples...... which had undergone gene silencing of the major allergen of apple, Mal d 1, by RNA interference. Downregulation of Mal d 1 gene expression in the apples was verified by qRT-PCR. Clinical responses to the genetically modified apples were compared to those seen with the wild-type Elstar using a visual...

  15. Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

    Science.gov (United States)

    Dunne, Aisling; Ejdeback, Mikael; Ludidi, Phumzile L; O'Neill, Luke A J; Gay, Nicholas J

    2003-10-17

    The Toll/interleukin 1 receptor (TIR) domain is a region found in the cytoplasmic tails of members of the Toll-like receptor/interleukin-1 receptor superfamily. The domain is essential for signaling and is also found in the adaptor proteins Mal (MyD88 adaptor-like) and MyD88, which function to couple activation of the receptor to downstream signaling components. Experimental structures of two Toll/interleukin 1 receptor domains reveal a alpha-beta-fold similar to that of the bacterial chemotaxis protein CheY, and other evidence suggests that the adaptors can make heterotypic interactions with both the receptors and themselves. Here we show that the purified TIR domains of Mal and MyD88 can form stable heterodimers and also that Mal homodimers and oligomers are dissociated in the presence of ATP. To identify structural features that may contribute to the formation of signaling complexes, we produced models of the TIR domains from human Toll-like receptor 4 (TLR4), Mal, and MyD88. We found that although the overall fold is conserved the electrostatic surface potentials are quite distinct. Docking studies of the models suggest that Mal and MyD88 bind to different regions in TLRs 2 and 4, a finding consistent with a cooperative role of the two adaptors in signaling. Mal and MyD88 are predicted to interact at a third non-overlapping site, suggesting that the receptor and adaptors may form heterotetrameric complexes. The theoretical model of the interactions is supported by experimental data from glutathione S-transferase pull-downs and co-immunoprecipitations. Neither theoretical nor experimental data suggest a direct role for the conserved proline in the BB-loop in the association of TLR4, Mal, and MyD88. Finally we show a sequence relationship between the Drosophila protein Tube and Mal that may indicate a functional equivalence of these two adaptors in the Drosophila and vertebrate Toll pathways.

  16. Alterações do desenvolvimento de crianças prematuras nascidas de mães com malária no periodo gestacional

    OpenAIRE

    Simões, Maria da Conceição Ribeiro

    2012-01-01

    Objetivo : O estudo buscou avaliar as alterações no desenvolvimento de crianças prematuras nascidas de mães com malária no periodo gestacional, em Porto Velho, Rondônia. O objetivo principal é descrever as alterações encontradas nessas crianças aplicando um teste preditivo para alterações no desenvolvimento e compará-las à um grupo controle de crianças prematuras nascidas de mães que não apresentaram malária no periodo gestacional. Métodos : Por ser um estudo do tipo transvers...

  17. Mal tiempo, tiempo maligno, tiempo de subversión ritual. La temposensitividad agrofestiva invernal

    Directory of Open Access Journals (Sweden)

    Del Campo Tejedor, Alberto

    2006-06-01

    ícolas y expresivo (rituales y fiestas; y, finalmente, un tiempo bipolar, que se experimenta desde antiguo en dos estaciones —invierno y verano—, base de una temposensitividad agrofestiva igualmente dicotómica, que es analizada a raíz de la siguiente hipótesis: durante los meses de buen tiempo, especialmente mayo y junio, los rituales de nuestro entorno funcionan con un sentido propiciatorio y de exaltación positiva, escenificando miméticamente la unión entre tierra, vegetación, animal y hombre a través de prototipos o arquetipos que recrean simbólicamente el orden natural de las cosas. Por el contrario, las fiestas y rituales invernales —desde Todos los Santos hasta el Carnaval, y muy especialmente los días en torno a la Navidad— tienen en común su carácter grotesco y de inversión del orden, que expresa en clave simbólica, con una lógica jocoseria y ambigua, el lado oscuro de la existencia, conjurando ritualmente los miedos al mal tiempo, al tiempo aciago y nefasto, al tiempo del frío, la noche, el hambre y la muerte.

  18. Mal de Asclepio o Síndrome Judicial Médico

    Directory of Open Access Journals (Sweden)

    Hernán Urbina Joiro

    2015-12-01

    Full Text Available

    Se asocian crecientemente, de manera criminal, abogados, pacientes y médicos perversos contra médicos honestos, alineando el factor que peor puede degradar la medicina de hoy y potenciar sus otros males. Siendo dios de la medicina, el nacimiento y la muerte de Asclepio estuvieron marcados por la vileza, la que hoy amenaza de muerte a la profesión médica. Pero no hay que olvidar que finalmente Asclepio pudo ser resguardado de la perversidad.

    No se trata de la situación de quien denuncia legítimamente una transgresión cometida por un médico. El Mal de Asclepio o Síndrome Judicial Médico describe la actuación calculada por auténticos «enfermos» —en el sentido sociopático—, con manifiesta intención de ocasionar daño a médicos inocentes, comúnmente a través de prácticas delictivas, ocasionando además males permanentes en la salud física y mental de quienes se habían esforzado, irónicamente, para sanar a los demás, en esta era de degradación de la profesión médica, en este momento extraño donde el bastón de Asclepio, dios de la medicina, fue cambiado por el caduceo de Mercurio, dios del comercio y también de los ladrones (1.

    Asclepio fue un hijo no nacido, rescatado por un prodigio desde el vientre de su madre muerta y a punto de ser consumida por la pira funeraria. Coronis —o Corónide—, la madre, lo concibió tras un asalto del dios Apolo en la rivera de un río y, sin saber de su estado, cumplió con un pacto matrimonial arreglado por su padre, lo que incitó a Apolo a dar muerte a su joven esposo e impulsó a Artemisa, hermana de Apolo, a asesinar a flechazos a la propia Coronis. Fue el mismo Apolo quien, en el último momento, resolvió extraer del cadáver de Coronis al niño que puso por nombre Asclepio y que en adelante lucharía contra la muerte, incluso resucitando difuntos, hasta que la propia muerte —Hades— convenció de mala fe a Zeus, lo indujo al error —que más tarde

  19. O problema do mal: a interpretação de São Boaventura = The problem of evil: the interpretation of Saint Bonaventure

    Directory of Open Access Journals (Sweden)

    Vasconcellos, Manoel

    2012-01-01

    Full Text Available Tomando, especialmente, o Breviloquium como guia, podemos entender o modo como São Boaventura analisa o problema do mal e sua relação com o pecado. O homem foi criado bom, para viver num mundo bom. Com o pecado, rompeu com o projeto divino, instaurando o mal no mundo. Deus, o princípio primeiro e perfeitíssimo, contudo, não deixa de levar à perfeição sua obra, razão pela qual vem ao encontro do homem para vencer o pecado e o mal. Numa reflexão em que Filosofia e Teologia se entrecruzam, Boaventura, ao discorrer sobre a origem, transmissão e superação do mal, deixa transparecer o papel singular e afirmativo do homem, pois, apesar do pecado, não perdeu sua atração natural às virtudes, sendo capaz de agir bem

  20. Development of hypo-allergenic apples: silencing of the major allergen Mal d 1 gene in "Elstar" apple and the effect of grafting

    DEFF Research Database (Denmark)

    Krath, Britta; Eriksen, Folmer Damsted; Pedersen, Bjarne H.

    2009-01-01

    Many people who are allergic to birch pollen are also allergic to apple fruit, due to cross-allergenicity. Since apples are the most extensively consumed fruit in Europe, it is highly relevant to develop a hypo-allergenic apple. Apples with significantly reduced levels of the allergen, Mal d 1, may...

  1. CADM1, MAL and miR124-2 methylation analysis in cervical scrapes to detect cervical and endometrial cancer

    NARCIS (Netherlands)

    De Strooper, Lise M. A.; van Zummeren, Marjolein; Steenbergen, Renske D. M.; Bleeker, Maaike C. G.; Hesselink, Albertus T.; Schuurs-Wisman, G. Bea A.; Snijders, Peter J. F.; Heideman, Danielle A. M.; Meijer, Chris J. L. M.

    2014-01-01

    Aims Gene promoter hypermethylation is recognised as an essential early step in carcinogenesis, indicating important application areas for DNA methylation analysis in early cancer detection. The current study was set out to assess the performance of CADM1, MAL and miR124-2 methylation analysis in

  2. Molecular characterization of multivalent bioconjugates by size-exclusion chromatography (SEC) with multi-angle laser light scattering (MALS)

    Science.gov (United States)

    Pollock, Jacob F.; Ashton, Randolph S.; Rode, Nikhil A.; Schaffer, David V.; Healy, Kevin E.

    2013-01-01

    The degree of substitution and valency of bioconjugate reaction products are often poorly judged or require multiple time- and product- consuming chemical characterization methods. These aspects become critical when analyzing and optimizing the potency of costly polyvalent bioactive conjugates. In this study, size-exclusion chromatography with multi-angle laser light scattering was paired with refractive index detection and ultraviolet spectroscopy (SEC-MALS-RI-UV) to characterize the reaction efficiency, degree of substitution, and valency of the products of conjugation of either peptides or proteins to a biopolymer scaffold, i.e., hyaluronic acid (HyA). Molecular characterization was more complete compared to estimates from a protein quantification assay, and exploitation of this method led to more accurate deduction of the molecular structures of polymer bioconjugates. Information obtained using this technique can improve macromolecular engineering design principles and better understand multivalent macromolecular interactions in biological systems. PMID:22794081

  3. La seducción del mal: crimen, arte, dictadura y poesía en "Estrella distante"

    OpenAIRE

    Díaz de la Cruz, Elena

    2017-01-01

    Trabajo de fin de Grado. Grado en Filología Hispánica. Curso académico 2016-2017 [ES]En la presente investigación se trabajará en torno al mal y su seducción a través del arte contemporáneo, la dictadura, el crimen, y todo ello envuelto en la poesía como forma de llevar a cabo la finalidad más antipoética que nos pudiéramos imaginar. El espacio “entre”, lo indefinido y el abismo va a ser el terreno donde la poesía cobra vida pero, además, crea un aura de diferentes posibilidades en torno a...

  4. Intrinsic magnetic properties of Sm2Fe17-xMxNy/Cy (M=Al, Ga or Si)

    International Nuclear Information System (INIS)

    Kubis, M.; Eckert, D.; Gebel, B.; Mueller, K.-H.; Schultz, L.

    2000-01-01

    Curie temperature T c , saturation polarization J s and anisotropy field H a of Sm 2 Fe 17-x M x N y /C y with M=Al, Ga or Si (x≤3, y∼3) were determined by thermomagnetic measurements and a numerical fitting procedure of demagnetization curves. An increasing amount of the substitutional element M leads to an increase of T c of the Sm 2 Fe 17-x M x parent compounds and generally to a decrease of T c , J s and H a for the interstitial nitrides and carbides. However, for small M contents, x≤1, an increased H a was observed compared to the substitution-free interstitial compounds. Gas-carburized and melt-carburized Sm 2 Fe 15 Ga 2 C y samples showed large differences in J s and H a but identical T c values

  5. Regresso às origens: pistas para a construção do bem e do mal

    Directory of Open Access Journals (Sweden)

    Miguel Ângelo Rodrigues Fernandes

    2011-01-01

    Full Text Available Nowadays, divisions still impose themselves. One of those divisions has become particularly relevant in contemporary culture. On one side, the Axis of Good. On the other, the Axis of Evil. In between both ends, conflicts for power. That dualism and those conflicts, building blocks of the process of constructing cultural identities, being contemporary, find part of their history in discourses of old, of which Christianity is a part. / Atualmente, as divisões continuam a impor-se. Uma dessas divisões tornou-se particularmente pregnante na cultura contemporânea. De um lado, o Eixo do Bem. Do outro, o Eixo do Mal. Mediando os dois polos, conflitos de poder. Esse dualismo e esses conflitos, constituintes do processo de construção de identidades culturais, ainda que contemporâneos, encontram parte da sua história em discursos antigos, que o Cristianismo integra.

  6. Viveret Patrick, 2005, Pourquoi ça ne va pas plus mal?, Fayard, 264 p.

    Directory of Open Access Journals (Sweden)

    Fabien Thurette

    2008-05-01

    Full Text Available Patrick Viveret est philosophe de formation et Conseiller-maître à la Cour des comptes. Il a, en outre, été chargé d’une mission, confiée par l'éphémère Secrétaire d'État à l'économie solidaire Guy Hascoët, puis prolongée par le Président Chirac sur une « autre approche de la richesse », dont le rapport final a été publié sous le titre Reconsidérer la richesse (2004.Dans son essai Pourquoi ça ne va pas plus mal ? publié en 2005, Patrick Viveret nous livre une analyse philosophique sur le « m...

  7. The method of producing climate change datasets impacts the resulting policy guidance and chance of mal-adaptation

    Directory of Open Access Journals (Sweden)

    Marie Ekström

    2016-12-01

    Full Text Available Impact, adaptation and vulnerability (IAV research underpin strategies for adaptation to climate change and help to conceptualise what life may look like in decades to come. Research draws on information from global climate models (GCMs though typically post-processed into a secondary product with finer resolution through methods of downscaling. Through worked examples set in an Australian context we assess the influence of GCM sub-setting, geographic area sub-setting and downscaling method on the regional change signal. Examples demonstrate that choices impact on the final results differently depending on factors such as application needs, range of uncertainty of the projected variable, amplitude of natural variability, and size of study region. For heat extremes, the choice of emissions scenario is of prime importance, but for a given scenario the method of preparing data can affect the magnitude of the projection by a factor of two or more, strongly affecting the indicated adaptation decision. For catchment level runoff projections, the choice of emission scenario is less dominant. Rather the method of selecting and producing application-ready datasets is crucial as demonstrated by results with opposing sign of change, raising the real possibility of mal-adaptive decisions. This work illustrates the potential pitfalls of GCM sub-sampling or the use of a single downscaled product when conducting IAV research. Using the broad range of change from all available model sources, whilst making the application more complex, avoids the larger problem of over-confidence in climate projections and lessens the chance of mal-adaptation.

  8. Light fractionation increases the efficacy of ALA-PDT but not of MAL-PDT: What is the role of (vascular) endothelial cells?

    Science.gov (United States)

    de Bruijn, H. S.; de Vijlder, H. C.; de Haas, E. R. M.; van der Ploeg-van den Heuvel, A.; Kruijt, B.; Poel-Dirks, D.; Sterenborg, H. J. C. M.; ten Hagen, T. L. M.; Robinson, D. J.

    2009-06-01

    Photodynamic therapy (PDT) using protoporpyrin IX (PpIX) precursors like 5-aminolevulinic acid (ALA) or methyl-aminolevulinate (MAL) has shown to be effective in the treatment of various skin diseases. Using ALA we have shown in numerous studies a significantly improved efficacy by applying light fractionation with a long dark interval. In contrast, in the hairless mouse model, the PDT efficacy using MAL is unaffected by adopting this approach. More acute edema is found after ALA-PDT suggesting a difference in response of endothelial cells to PDT. To investigate the role of endothelial cells, cryo-sections of hairless mouse skin after 4 hours of topical MAL or ALA application were stained with a fluorescent endothelial cell marker (CD31). Co-localization of this marker with the PpIX fluorescence was performed using the spectral imaging function of the confocal microscope. We have also used intra-vital confocal microscopy to image the PpIX fluorescence distribution in correlation with the vasculature of live mouse skin. Our results show PpIX fluorescence at depth in cryo-sections of mouse skin after 4 hours of topical application. Co-localization has shown to be difficult due to the changes in tissue organization caused by the staining procedure. As expected we found high PpIX fluorescence levels in the epidermis after both MAL and ALA application using intra-vital microscopy. After ALA application more PpIX fluorescence was found deep in the dermal layer of the skin than after MAL. Furthermore we detected localized fluorescence in unidentified structures that could not be correlated to blood vessels or nerves.

  9. First successful reduction of clinical allergenicity of food by genetic modification: Mal d 1-silenced apples cause fewer allergy symptoms than the wild-type cultivar.

    Science.gov (United States)

    Dubois, A E J; Pagliarani, G; Brouwer, R M; Kollen, B J; Dragsted, L O; Eriksen, F D; Callesen, O; Gilissen, L J W J; Krens, F A; Visser, R G F; Smulders, M J M; Vlieg-Boerstra, B J; Flokstra-de Blok, B J; van de Weg, W E

    2015-11-01

    Genetic modification of allergenic foods such as apple has the potential to reduce their clinical allergenicity, but this has never been studied by oral challenges in allergic individuals. We performed oral food challenges in 21 apple-allergic individuals with Elstar apples which had undergone gene silencing of the major allergen of apple, Mal d 1, by RNA interference. Downregulation of Mal d 1 gene expression in the apples was verified by qRT-PCR. Clinical responses to the genetically modified apples were compared to those seen with the wild-type Elstar using a visual analogue scale (VAS). Gene silencing produced two genetically modified apple lines expressing Mal d 1.02 and other Mal d 1 gene mRNA levels which were extensively downregulated, that is only 0.1-16.4% (e-DR1) and 0.2-9.9% (e-DR2) of those of the wild-type Elstar, respectively. Challenges with these downregulated apple lines produced significantly less intense maximal symptoms to the first dose (Vmax1) than with Elstar (Vmax1 Elstar 3.0 mm vs 0.0 mm for e-DR1, P = 0.017 and 0.0 mm for e-DR2, P = 0.043), as well as significantly less intense mean symptoms per dose (meanV/d) than with Elstar (meanV/d Elstar 2.2 mm vs 0.2 mm for e-DR1, P = 0.017 and 0.0 mm for e-DR2, P = 0.043). Only one subject (5%) remained symptom-free when challenged with the Elstar apple, whereas 43% did so with e-DR1 and 63% with e-DR2. These data show that mRNA silencing of Mal d 1 results in a marked reduction of Mal d 1 gene expression in the fruit and reduction of symptoms when these apples are ingested by allergic subjects. Approximately half of the subjects developed no symptoms whatsoever, and virtually all subjects wished to consume the apple again in the future. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. O puru-puru da Amazônia (Pinta, Carate, Mal del Pinto etc

    Directory of Open Access Journals (Sweden)

    F. Nery Guimarães

    1948-03-01

    Full Text Available 1 "Purú-purú" é uma palavra indígena que quer dizer "pintado" ou "manchado", peculiar à Amazonia Brasileira. Com êsse nome é designada uma dermatose referida entre os selvicolas desde 1774, por Ribeiro Sampaio. Certas tribus, com alta incidência da moléstia passaram a ser cahamadas também "Purú-purús", o mesmo acontecendo com o rio onde habitavam - Rio Purús. 2 A doença existe na bacia do Rio Solimões e seus principais afluentes: Javari, Juruá, Purús, Içá, Japurá, e Negro. Por esses rios, o fóco da dermatose se continua nos países limitrofes com o Brasil: Guianas, Venezuela, Colombia, Perú (Equador e Bolivia. 3 Desde 1890 essa dermatose foi relacionada à pinta (carate ou mal del pinto por P. S. de Magalhães, idéa essa depois defendida por Juliano Moreira, Carlos Chagas, Roquete Pinto, Wappeus, O. da Fonseca Filho, Da Matta, Brumpt e outros, baseados na semelhança clínica e na terapêutica. Recentemente (1945, essa provavel identidade das duas dermatoses, recebeu fundamento sorológico de Biocca (que verificou a positividade das reações de Kline e Kahn em doentes de purú-purú, e, pelo presente trabalho, recebe base clínico-epidemio-anatomo-patológica. 4 Sob o ponto de vista clínico, as lesões cutaneas discromicas da moléstia, são de 3 órdens: a lesões papulo-eritemato-escamosas, isoladas ou não, arredondadas, pruriginosas e de bordos nitidos; b lesões maculo-escamosas, maiores mais pálidas, ás vezes já mostrando alterações pigmentares na parte central; c máculas discromod´rmicas, lisas ou ligeiramente escamosas, com maior ou menor alteração pigmentar, as quais assumem diferentes aspéctos, consequentes à hipo - ou hiperpigmentação, variaveis também com a côr do paciente. As colorações predominantes nas manchas, são o branco, o preto e o vermelho, com tonalidades eminentemente variaveis. Embora raramente, nessas extensas dermodiscromias, observa-se superposição de lesões papulo

  11. Buddha and tiger; Mal Buddha, mal Tiger

    Energy Technology Data Exchange (ETDEWEB)

    Schott, Christina

    2010-02-15

    Thailand is foremost in renewable energy in South East Asia, and the country is planning to extend its capacities in this field. At the same time, the country dreams of atomic energy and also pushes doubtful megascale projects in its neighbouring countries. (orig.)

  12. Contribuição ao estudo do mal de cadeiras na Ilha de Marajó

    Directory of Open Access Journals (Sweden)

    Geth Jansen

    1941-01-01

    Full Text Available Como resultado de inspeções feitas à ilha de Marajó o autor assinala: 1º O mal de cadeiras continua existindo na ilha de Marajó sob a forma enzoótica, ao contrário do que pensavam os criadores, julgando-o extinto. As doenças designadas por estes como "barriga inchada" e "mormo seco", responsaveis pela grande mortalidade dos equinos, foram identificadas pelo autor como tal de cadeiras. 2º O autor considera indispensável para a pesquisa do trypanosoma o processo de inoculação em animais de laboratório, tendo utilizado para esse fim camondongos e ratos brancos. 3º Os surtos epizoóticos anuais coincidem com a época das chuvas, ocasião em que surgem os insetos hematófagos, o que faz pensar no papel desses últimos como transmissores. 4º Os cavalos podem atravessar o ano com trypanosomas no sangue e em estado de saude aparente, constituindo assim depositários do mal de cadeiras. 5º O extermínio da capivara, em consequência do seu aproveitamento econômico não modificou o carater endêmico da doença na ilha de Marajó. 6º O autor observou que os trypanosomas no tubo digestivo de Stomoxys e Tabanideos, ao cabo de 8 horas, apresentavam com movimentos diminuidos e em formas arrendondadas, não conseguindo inoculações positivas com esse material. 7º A saliva de um morcego do gênero Desmodus, que se infectou no laboratório, alimentando-se em animal doente, colhida de modo a evitar lesões da mucosa e consequente contaminação pelos trypanosomas do sangue circulante, mostrou-se incapaz de infectar, por inoculação, animais sensiveis. Este mesmo morcego não transmitiu a doença a um cão, o qual sugou durante 80 dias. Recentemente (1941 empregando um exemplar do gênero Desmodus, também infectado experimentalmente por alimentação em animal de laboratório, conseguimos transmitir o Trypanosoma equinum a uma cobaia normal. Este assunto será ventilado posteriormente.

  13. SUPERVISION IMPLEMENTATION IN MANAGEMENT QUALITY: AN ATTEMPT TO IMPROVE THE QUALITY OF LEARNING AT MADRASAH ALIYAH DARUL A’MAL METRO

    Directory of Open Access Journals (Sweden)

    Subandi Subandi

    2016-03-01

    Full Text Available The primary purpose of this qualitative study is to identify and analyze supervision by implementing management quality to improve the quality of learning at Madrasah Aliyah Darul A’mal Metro, Lampung. The quality of management implementation is elaborated in the steps of assurance of learning quality. Two instruments, which consist of observation and questionnaire, were used in this study of which each instrument was analyzed based the deductive framework. The results of this study from each instrument revealed four steps of assurance of learning quality, among others (1 by socializing academic supervision program and its advantages to all stake holders, and (2 by implementing stages of assurance through academic supervision by the principals of Madrasah Aliyah Darul A’mal and supervisor, (3 performing supervision that is equipped with valid instrument to measure learning success, (4 performing the follow-up program by clinical and group discussion to provide appropriate model of performance.

  14. Crystallization, data collection and data processing of maltose-binding protein (MalE) from the phytopathogen Xanthomonas axonopodis pv. citri

    International Nuclear Information System (INIS)

    Souza, C. S.; Ferreira, L. C. S.; Thomas, L.; Barbosa, J. A. R. G.; Balan, A.

    2009-01-01

    The Xanthomonas axonopodis pv. citri maltose-binding protein MalE has been crystallized at 293 K using the hanging-drop vapour-diffusion method. Maltose-binding protein is the periplasmic component of the ABC transporter responsible for the uptake of maltose/maltodextrins. The Xanthomonas axonopodis pv. citri maltose-binding protein MalE has been crystallized at 293 K using the hanging-drop vapour-diffusion method. The crystal belonged to the primitive hexagonal space group P6 1 22, with unit-cell parameters a = 123.59, b = 123.59, c = 304.20 Å, and contained two molecules in the asymetric unit. It diffracted to 2.24 Å resolution

  15. Avaliação de genótipos tetraploides de bananeira cultivados em área infestada pelo agente causal do mal-do-Panamá

    Directory of Open Access Journals (Sweden)

    Sebastião de Oliveira e Silva

    2011-03-01

    Full Text Available O mal-do-Panamá é uma doença que causa grandes prejuízos à bananicultura no Brasil, uma vez que as principais cultivares em uso são suscetíveis ao Fusarium. Este trabalho teve como objetivos avaliar características agronômicas e resistência ao mal-do-Panamá de híbridos tetraploides de bananeira. O experimento foi conduzido no campo experimental da Embrapa Mandioca e Fruticultura Tropical, em delineamento casualizado, com 14 tratamentos e 10 repetições, nos anos de 2000 e 2001. Foram avaliados 14 tetraploides (FHIA-03, PV03-44, PC42-01, PV42-53, PV42-68, PV42-81, PV42-85, PV42-129, PV42-142, PV42-143, SH3640, ST12-31, ST42-08 e YB42-21 e a cultivar Maçã, usada como testemunha. Avaliaram-se as características altura da planta (m e diâmetro do pseudocaule (cm a 30 cm do solo, peso da massa do cacho (kg, penca (kg e fruto (g, número de pencas por cacho, de frutos por penca e de dias do florescimento à colheita, e a incidência do mal-do-Panamá. As médias dos genótipos foram agrupadas pelo teste de Scott e Knott, a 5% de probabilidade. Observa-se uma ampla variação genética nos caracteres avaliados. Os genótipos FHIA 03, ST12-31, SH3640, PV42-142, PV42-53 e PV42-68apresentam boas características agronômicas e resistência ao mal-do-Panamá.

  16. Lower expression of CADM1 and higher expression of MAL in Merkel cell carcinomas are associated with Merkel cell polyomavirus infection and better prognosis.

    Science.gov (United States)

    Iwasaki, Takeshi; Matsushita, Michiko; Nonaka, Daisuke; Nagata, Keiko; Kato, Masako; Kuwamoto, Satoshi; Murakami, Ichiro; Hayashi, Kazuhiko

    2016-02-01

    Merkel cell carcinoma (MCC) is a clinically aggressive neuroendocrine skin cancer; 80% of the cases are associated with the Merkel cell polyomavirus (MCPyV). We previously reported that MCPyV-negative MCCs have more irregular nuclei with abundant cytoplasm and significantly unfavorable outcomes than do MCPyV-positive MCCs. These results suggest that some cell adhesion or structural stabilization molecules are differently expressed depending on MCPyV infection status. Thus, we investigated the association of prognosis or MCPyV infection status in MCCs with cell adhesion molecule 1 (CADM1)/differentially expressed in adenocarcinoma of the lung protein 1 (DAL-1)/membrane protein, palmitoylated 3 (MPP3) tripartite complex and mal T-cell differentiation protein (MAL) expression, which play important roles in cell adhesion and oncogenesis and are related to cancer outcomes in various malignancies, to elucidate the role of these molecules. We analyzed the pathological and molecular characteristics of 26 MCPyV-positive and 15 MCPyV-negative MCCs. Univariate Cox regression analysis showed that advanced age (hazard ratio [HR], 8.249; P = .007) and high CADM1 expression (HR, 5.214; P = .012) were significantly unfavorable overall survival parameters, whereas MCPyV infection (HR, 0.043, P Merkel cells expressed DAL-1 and MAL but not CADM1. This study revealed that MCPyV-negative MCCs significantly expressed higher CADM1 and lower MAL than MCPyV-positive MCCs; these expression levels were markedly related to unfavorable outcomes. These data will give us important insights to develop novel molecular target therapies for MCCs. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. Efeito de ação educativa participativa no conhecimento de professores do ensino básico sobre malária

    Directory of Open Access Journals (Sweden)

    Martha Cecilia Suárez-Mutis

    2011-10-01

    Full Text Available OBJETIVO: Descrever uma estratégia educativa participativa de construção de conhecimentos relacionados à malária entre professores em um município altamente endêmico. MÉTODOS: Foi feito um estudo observacional. Um curso de 40 horas foi realizado sob enfoque multidisciplinar e problematizador para 46 professores, prioritariamente da área rural, no município de Barcelos, AM, em 2008. O processo educativo participativo incluiu oficinas e aulas práticas. Para investigar os conhecimentos, aplicou-se um questionário previamente validado, antes e após o curso, avaliado por abordagens quantitativa e qualitativa usando a análise temática para respostas abertas. RESULTADOS: Previamente ao curso, os professores tinham pouca informação sobre os mecanismos de transmissão, meios de prevenção e a associação da malária aos seus vetores, bem como conceitos restritos sobre saúde. Após o curso, não somente aumentou o conhecimento dos professores sobre a malária como também emergiram reflexões sobre o papel do professor na sociedade. CONCLUSÕES: O efeito da ação educativa na construção de um saber contextualizado sobre malária e saúde indica o potencial da estratégia desenvolvida. Processos de educação permanente são necessários à sustentabilidade dos novos saberes e práticas, orientados pela promoção da saúde.

  18. Geography, population, demography, socioeconomic, anthropometry, and environmental status in the MAL-ED cohort and case-control study Sites in Fortaleza, Ceará, Brazil.

    Science.gov (United States)

    Lima, Aldo A M; Oriá, Reinaldo B; Soares, Alberto M; Filho, José Q; de Sousa, Francisco; Abreu, Cláudia B; Bindá, Alexandre; Lima, Ila; Quetz, Josiane; Moraes, Milena; Maciel, Bruna; Costa, Hilda; Leite, Alvaro M; Lima, Noélia L; Mota, Francisco S; Di Moura, Alessandra; Scharf, Rebecca; Barrett, Leah; Guerrant, Richard L

    2014-11-01

    The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort in the study's Fortaleza, Brazil, catchment area has a population of approximately 82 300 inhabitants. Most of the households (87%) have access to clean water, 98% have electricity, and 69% have access to improved toilet/sanitation. Most childbirths occur at the hospital, and the under-5 mortality rate is 20 per 1000 live births. The MAL-ED case-control study population, identified through the Institute for the Promotion of Nutrition and Human Development (IPREDE), serves 600 000 inhabitants from areas totaling about 42% of the city of Fortaleza. IPREDE receives referrals from throughout the state of Ceará for infant nutrition, and provides services including teaching activities and the training of graduate students and health professionals, while supporting research projects on child nutrition and health. In this article, we describe the geographic, demographic, socioeconomic, anthropometric, and environmental status of the MAL-ED cohort and case-control study populations in Fortaleza, Brazil. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  19. Transglycosylation properties of maltodextrin glucosidase (MalZ) from Escherichia coli and its application for synthesis of a nigerose-containing oligosaccharide

    Energy Technology Data Exchange (ETDEWEB)

    Song, Kyung-Mo [Center for Agricultural Biomaterials and Department of Food Science and Biotechnology, Seoul National University, Seoul 151-921 (Korea, Republic of); Shim, Jae-Hoon [Department of Biology, University of Incheon, Incheon 406-772 (Korea, Republic of); Park, Jong-Tae; Kim, Sung-Hee [Center for Agricultural Biomaterials and Department of Food Science and Biotechnology, Seoul National University, Seoul 151-921 (Korea, Republic of); Kim, Young-Wan [Department of Food and Biotechnology, Korea University, Jochiwon 339-700 (Korea, Republic of); Boos, Winfried [Department of Biology, University of Konstanz, Konstanz 78457 (Germany); Park, Kwan-Hwa, E-mail: parkkh@incheon.ac.kr [Department of Biology, University of Incheon, Incheon 406-772 (Korea, Republic of)

    2010-06-18

    The transglycosylation reaction of maltodextrin glucosidase (MalZ) cloned and purified from Escherichia coli K12 was characterized and applied to the synthesis of branched oligosaccharides. Purified MalZ preferentially catalyzed the hydrolysis of maltodextrin, {gamma}-cyclodextrin (CD), and cycloamylose (CA). In addition, when the enzyme was incubated with 5% maltotriose (G3), a series of transfer products were produced. The resulting major transfer products, annotated as T1, T2, and T3, were purified and their structures were determined by TLC, MALDI-TOF/MS, {sup 13}C NMR, and enzymatic analysis. T1 was identified as a novel compound, maltosyl {alpha}-1,3-maltose, whereas T2 and T3 were determined to be isopanose and maltosyl-{alpha}-1,6-maltose, respectively. These results indicated that MalZ transferred sugar moiety mainly to C-3 or C-6-OH of glucose of the acceptor molecule. To obtain highly concentrated transfer products, the enzyme was reacted with 10% liquefied cornstarch, and then glucose and maltose were removed by immobilized yeast. The T1 content of the resulting reaction mixture reached 9.0%. The mixture of T1 containing a nigerose moiety can have an immunopotentiating effect on the human body and may be a potential functional sugar stuff.

  20. Gross Mal distribution Identification and Effect of Inlet Distributor on the Phase Holdup in a Trickle Bed Reactor Using Gamma-Ray Densitometry (GRD)

    International Nuclear Information System (INIS)

    Mohd Fitri Abdul Rahman; Alexander, V.; Al-Dahhan, M.

    2016-01-01

    Local liquid and gas mal distribution and their holdups in a packed column are difficult to identify due to multiphase properties and other design factors. Good liquid and gas flow distribution important to determine to get high performance of Trickle Bed Reactor (TBR). Gross mal distribution indicates some faulty or bad flow distribution of liquid and gas. In this work, gross mal distribution of phases has been identified using Gamma Ray Densitometry (GRD) technique with three types of inlet distributors (single inlet towards the wall, single inlet at the center, and proper shower) by measuring line average diameter profile of phases (Liquid, Gas, and Solids) holdups. Gamma-ray densitometry is a non-invasive technique which can be implemented at the laboratory, pilot plant, and industrial scales reactors. Experiments were performed on 0.14 m diameter reactor made of Plexiglas filled with 0.003 m glass bead which acts as the solid. The superficial velocities for both gas and liquid were in the range 0.03 m/s to 0.27 m/s and 0.004 m/s to 0.014 m/s respectively. Proper shower distributor showed early liquid spreading than compared with other distributors. The effect of superficial gas velocity on liquid spread was seen to be non-significant, and liquid distribution is found to be almost uniform at the center region of the catalyst bed. (author)

  1. A democracia no Brasil não é um mal-entendido = Democracy in Brazil is not a misunderstanding

    Directory of Open Access Journals (Sweden)

    Coelho, Maria Francisca Pinheiro

    2014-01-01

    Full Text Available A ideia deste trabalho surgiu da famosa frase de Sérgio Buarque de Holanda, em Raízes do Brasil: “A democracia no Brasil foi sempre um lamentável mal-entendido. ” Para o autor, inspirado nos tipos ideais weberianos e sob um olhar comparativo, o Brasil com seu homem cordial – aquele que age mais pelo coração do que pela razão – e com o predomínio do espaço privado sobre o público não se apresentava como um solo receptivo aos valores de igualdade da democracia. O texto pretende sugerir que a institucionalização das regras do jogo democrático relativiza o peso da cultura, sem, contudo, alterar seus traços no ritmo compatível com as mudanças das normas. O Brasil, com todos os problemas decorrentes de uma sociedade desigual e hierárquica, situa-se atualmente entre as democracias mais consolidadas da América Latina, que mais interagem e que apresentam disposição para o diálogo

  2. Surto de malária por Haemoproteus columbae em pombos An outbreak of malaria by Haemoproteus columbae in pigeons

    Directory of Open Access Journals (Sweden)

    J.S. Resende

    2001-06-01

    Full Text Available Relata-se um surto de malária por Haemoproteus columbae em pombos-correio (Columba livia, caracterizado por um quadro agudo com mortalidade de 3% ao dia em aves de aspecto saudável ou crônico com prostração e fraqueza. O exame clínico das aves doentes evidenciou sinusite e conjuntivite e à necropsia traqueíte hemorrágica, aerossaculite, esplenomegalia, nefromegalia e hepatomegalia com hemorragias. O díptero hematófago da família Hippoboscidae Pseudolynchia canariensis foi encontrado inserido entre as penas dos indivíduos. Esfregaços de sangue periférico e cardíaco e impressões de baço e fígado corados por Giemsa permitiram a visualização de inclusões intraeritrocitárias características de Haemoproteus columbae

  3. Instrumentação anterior da coluna em espondilite tuberculosa mal de pott: Relato de caso

    Directory of Open Access Journals (Sweden)

    Farage Luciano

    2002-01-01

    Full Text Available Relatamos caso de tratamento cirúrgico com instrumentação anterior em espondilite tuberculosa (mal de Pott, em mulher de 71 anos, que se encontrava em tratamento para tuberculose na forma pulmonar e evoluiu com dor lombar, dificuldade progressiva para deambular, cifose e disfunção vesical. A ressonância magnética revelou lesão nos corpos vertebrais de T12 e L1 com abcesso paravertebral. A paciente foi tratada cirurgicamente por acesso tóraco-abdominal lateral. Os corpos vertebrais foram ressecados, foi instalado uma gaiola vertical (mesh cage e a coluna foi estabilizada com placa lateral (Z plate e parafusos fixados em T11 e L2. Essa técnica permite boa artrodese dos corpos vertebrais remanescentes e boa estabilidade da coluna, sem comprometer a eficácia dos tuberculostáticos. A paciente foi avaliada um ano após a operação e não apresentava déficit motor, dor residual e a cifose foi desfeita.

  4. Malária no Brasil: panorama epidemiológico na última década

    Directory of Open Access Journals (Sweden)

    Barata Rita de Cássia B.

    1995-01-01

    Full Text Available Este artigo apresenta, de maneira resumida, as principais alterações que marcaram a ocorrência de malária, no Brasil, nesta última década. Chama-se a atenção para o processo de focalização da doença, com a concentração da transmissão em áreas, relativamente restritas, da região amazônica. A mudança na situação epidemiológica acarreta a revisãoconceitual, levando ao abandono da concepção de "doença de massa" e à elaboração da teoria focal. Do mesmo modo, as ações de controle sofrem os impactos das transformações ocorridas e as tentativas de erradicação são abandonadas e substituídas por medidas de controle diversificadas e adaptadas a cada localidade. As novas propostas, oriundas da Conferência Ministerial de Amsterdam, são apresentadas e comentadas.

  5. Structural distortions in Sr3-xAxMO4F (A=Ca, Ba; M=Al, Ga, In) anti-Perovskites and corresponding changes in photoluminescence

    International Nuclear Information System (INIS)

    Sullivan, Eirin; Avdeev, Maxim; Vogt, Thomas

    2012-01-01

    The ordered oxyfluoride family Sr 3 − x A x MO 4 F (A=Ca, Ba and M=Al, Ga) has formed the basis of several new inorganic phosphors, and shows great potential for use in phosphor-conversion LED lamp devices. This study examines the correlation between subtle structural changes and photoluminescent behaviour in some of these materials. In order to ascertain whether cation charge compensation has any influence on structure and subsequent photoluminescent behaviour, a comparison was carried out between phases with the nominal compositions Sr 2.975 Ce 0.025 AlO 4 F and Sr 2.95 Ce 0.025 Na 0.025 AlO 4 F using structural characterisation based upon high-resolution neutron powder diffraction (NPD) data. Additionally, NPD data has been used to elucidate the role of different M cations in these materials, using Sr 2.25 Ba 0.6 Eu 0.1 M 0.95 In 0.05 O 4−α F 1−δ (M=Al, Ga) to determine the effect M cation size has on structure and photoluminescent properties. - Graphical abstract: The structure of Sr3-xAxMO4F (A=Ca, Ba and M=Al, Ga) and excitation and emission spectra for Sr 2.25 Ba 0.6 Eu 0.1 Ga 0.95 In 0.05 O 4−α F 1−δ . Highlights: ► Correlation between structural changes and photoluminescence in Sr 3−x A x MO 4 F (A=Ca, Ba, M=Al, Ga). ► Comparison of Sr 2.975 Ce 0.025 AlO 4 F and Sr 2.95 Ce 0.025 Na 0.025 AlO 4 F using high-resolution NPD. ► Study of the effect of cation charge-compensation on structure and photoluminescent behaviour. ► Examination of high-resolution NPD data for Sr 2.25 Ba 0.6 Eu 0.1 M 0.95 In 0.05 O 4−α F 1−δ (M=Al, Ga). ► Determination of the effect M cation size has on structure and photoluminescent properties.

  6. An ecosystem approach to malaria control in an urban setting Uma abordagem ecossistêmica ao controle da malária em contexto urbano

    Directory of Open Access Journals (Sweden)

    Gabriel Carrasquilla

    2001-01-01

    Full Text Available We conducted a research project aimed at strengthening local government and the community for a sustainable malaria control strategy. The project began with a baseline diagnosis of malaria prevalence, a KAP survey, entomology, and health services delivery, after which an epidemiological study was performed to identify risk factors associated with malaria, thereafter used to plan intervention measures. A program evaluation was conducted five years later. By using an ecosystem approach to reanalyze data, this paper discusses how malaria arises from a complex interaction of cultural, economic, ecological, social, and individual factors. Intervention measures require an intersectorial and transdisciplinary approach that does not exist at the moment. Health sector leadership is limited, and there is no true community participation. Implications for research, including the use of qualitative and quantitative methods, study design, and complexity of data analysis are discussed. Finally, implications for malaria control are discussed, stressing the differences between the ecosystem and integrated disease control approaches.Os autores implementaram um projeto de pesquisa voltado ao fortalecimento do governo local e da comunidade com vistas à estratégia sustentável de controle da malária. O projeto iniciou com diagnóstico prévio, incluindo prevalência da malária, entomologia, KAP (conhecimentos, atitudes e práticas e oferta de serviços de saúde; a seguir, realizou-se inquérito epidemiológico para identificar fatores de risco associados à malária e a escolha de medidas de intervenção adequadas. O programa foi avaliado após cinco anos. Ao adotar a abordagem ecossistêmica para re-analisar os dados, o artigo discute como a malária surge a partir da interação complexa entre fatores culturais, econômicos, ecológicos, sociais e individuais. Medidas de intervenção exigem abordagem intersetorial e transdisciplinar ainda não existente. A

  7. «Gente de mal vivir»: families and incorrigible sons in new Spain, 1721-1729

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    Cáceres Menéndez, Beatriz

    2006-08-01

    Full Text Available Forced transportation to the Philippine and Mariana Islands, a form of social exile and the equivalent of deportation, was used in New Spain to punish criminals and people judged to be undesirable. Those who were sent across the Pacific were always male and usually American-born Spaniards. Both the viceregal government and parents thought forced transportation to be an appropriate way to rid Mexico not only of criminals but also of men «of evil living» - people whose lives were dedicated to gambling, public drunkenness, idleness, and immorality. Parents, brothers, and even wives therefore used forced transportation to eliminate unwanted family members whose behavior threatened to tarnish family honor.

    En la Nueva España el traslado forzoso de individuos a las Islas Filipinas y Marianas fue una forma de exilio equivalente a la deportación para castigar a los criminales y a la gente considerada indeseable. Los condenados fueron siempre hombres y usualmente españoles nacidos en América. Tanto el gobierno virreinal como los padres de familia pensaron en el traslado forzoso como un medio apropiado para limpiar el Reino no sólo de criminales sino también de «gente de mal vivir», es decir, aquellos dedicados al juego, la embriaguez pública, la ociosidad y la inmoralidad. Padres, hermanos y aún esposas utilizaron el traslado obligado como un medio para eliminar a los familiares cuyos comportamientos amenazaban manchar el honor de la familia.

  8. Cloning and Molecular Characterization of an Alpha-Glucosidase (MalH) from the Halophilic Archaeon Haloquadratum walsbyi.

    Science.gov (United States)

    Cuebas-Irizarry, Mara F; Irizarry-Caro, Ricardo A; López-Morales, Carol; Badillo-Rivera, Keyla M; Rodríguez-Minguela, Carlos M; Montalvo-Rodríguez, Rafael

    2017-11-21

    We report the heterologous expression and molecular characterization of the first extremely halophilic alpha-glucosidase (EC 3.2.1.20) from the archaeon Haloquadratum walsbyi . A 2349 bp region ( Hqrw_2071 ) from the Hqr. walsbyi C23 annotated genome was PCR-amplified and the resulting amplicon ligated into plasmid pET28b(+), expressed in E. coli Rosetta cells, and the resulting protein purified by Ni-NTA affinity chromatography. The recombinant protein showed an estimated molecular mass of 87 kDa, consistent with the expected value of the annotated protein, and an optimal activity for the hydrolysis of α-PNPG was detected at 40 °C, and at pH 6.0. Enzyme activity values were the highest in the presence of 3 M NaCl or 3-4 M KCl. However, specific activity values were two-fold higher in the presence of 3-4 M KCl when compared to NaCl suggesting a cytoplasmic localization. Phylogenetic analyses, with respect to other alpha-glucosidases from members of the class Halobacteria, showed that the Hqr. walsbyi MalH was most similar (up to 41%) to alpha-glucosidases and alpha-xylosidases of Halorubrum . Moreover, computational analyses for the detection of functional domains, active and catalytic sites, as well as 3D structural predictions revealed a close relationship with an E. coli YicI-like alpha-xylosidase of the GH31 family. However, the purified enzyme did not show alpha-xylosidase activity. This narrower substrate range indicates a discrepancy with annotations from different databases and the possibility of specific substrate adaptations of halophilic glucosidases due to high salinity. To our knowledge, this is the first report on the characterization of an alpha-glucosidase from the halophilic Archaea, which could serve as a new model to gain insights into carbon metabolism in this understudied microbial group.

  9. Cloning and Molecular Characterization of an Alpha-Glucosidase (MalH from the Halophilic Archaeon Haloquadratum walsbyi

    Directory of Open Access Journals (Sweden)

    Mara F. Cuebas-Irizarry

    2017-11-01

    Full Text Available We report the heterologous expression and molecular characterization of the first extremely halophilic alpha-glucosidase (EC 3.2.1.20 from the archaeon Haloquadratum walsbyi. A 2349 bp region (Hqrw_2071 from the Hqr. walsbyi C23 annotated genome was PCR-amplified and the resulting amplicon ligated into plasmid pET28b(+, expressed in E. coli Rosetta cells, and the resulting protein purified by Ni-NTA affinity chromatography. The recombinant protein showed an estimated molecular mass of 87 kDa, consistent with the expected value of the annotated protein, and an optimal activity for the hydrolysis of α-PNPG was detected at 40 °C, and at pH 6.0. Enzyme activity values were the highest in the presence of 3 M NaCl or 3–4 M KCl. However, specific activity values were two-fold higher in the presence of 3–4 M KCl when compared to NaCl suggesting a cytoplasmic localization. Phylogenetic analyses, with respect to other alpha-glucosidases from members of the class Halobacteria, showed that the Hqr. walsbyi MalH was most similar (up to 41% to alpha-glucosidases and alpha-xylosidases of Halorubrum. Moreover, computational analyses for the detection of functional domains, active and catalytic sites, as well as 3D structural predictions revealed a close relationship with an E. coli YicI-like alpha-xylosidase of the GH31 family. However, the purified enzyme did not show alpha-xylosidase activity. This narrower substrate range indicates a discrepancy with annotations from different databases and the possibility of specific substrate adaptations of halophilic glucosidases due to high salinity. To our knowledge, this is the first report on the characterization of an alpha-glucosidase from the halophilic Archaea, which could serve as a new model to gain insights into carbon metabolism in this understudied microbial group.

  10. Efficacy and safety of 4 months of sublingual immunotherapy with recombinant Mal d 1 and Bet v 1 in patients with birch pollen-related apple allergy.

    Science.gov (United States)

    Kinaciyan, Tamar; Nagl, Birgit; Faustmann, Sandra; Frommlet, Florian; Kopp, Stephan; Wolkersdorfer, Martin; Wöhrl, Stefan; Bastl, Katharina; Huber, Hans; Berger, Uwe; Bohle, Barbara

    2018-03-01

    Birch pollen-related apple allergy is among the most prevalent food allergies in adolescent/adult subjects and mainly results from sensitization to the major birch pollen allergen Bet v 1 and subsequent cross-reaction with the apple protein Mal d 1. However, specific immunotherapy with birch pollen has inconsistent effects on apple allergy. We sought to compare the safety and efficacy of sublingual immunotherapy (SLIT) with 2 formulations containing either rMal d 1 or rBet v 1 on birch pollen-related apple allergy. Sixty participants with birch pollen-related apple allergy were randomized to daily sublingual application of placebo (n = 20) or 25 μg of rMal d 1 (n = 20) or rBet v 1 (n = 20) for 16 weeks. Adverse events were regularly recorded. Sublingual challenges with standardized doses of rMal d 1, skin prick tests with recombinant allergens, and measurements of allergen-specific IgE and IgG 4 antibodies were performed before and after treatment. Both formulations caused comparable, mainly local adverse events. No systemic reactions occurred. Compared with the placebo and rBet v 1-treated groups, SLIT with rMal d 1 reduced rMal d 1-induced oral symptoms (P = .001 and P = .038) accompanied by longitudinally reduced rMal d 1-specific cutaneous reactions (P = .022) and enhanced IgG 4 /IgE ratios (P = .012). SLIT with rBet v 1 neither improved the clinical reactivity to rMal d 1 nor enhanced rMal d 1-specific IgG 4 /IgE ratios. Participants receiving placebo showed no allergen-specific changes. Sublingual treatment with a recombinant food allergen was safe and clinically effective, as determined by using standardized challenges. We present a promising approach for the effective treatment of birch pollen-related apple allergy. Copyright © 2017 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

  11. MosquitoMap and the Mal-area calculator: new web tools to relate mosquito species distribution with vector borne disease.

    Science.gov (United States)

    Foley, Desmond H; Wilkerson, Richard C; Birney, Ian; Harrison, Stanley; Christensen, Jamie; Rueda, Leopoldo M

    2010-02-18

    Mosquitoes are important vectors of diseases but, in spite of various mosquito faunistic surveys globally, there is a need for a spatial online database of mosquito collection data and distribution summaries. Such a resource could provide entomologists with the results of previous mosquito surveys, and vector disease control workers, preventative medicine practitioners, and health planners with information relating mosquito distribution to vector-borne disease risk. A web application called MosquitoMap was constructed comprising mosquito collection point data stored in an ArcGIS 9.3 Server/SQL geodatabase that includes administrative area and vector species x country lookup tables. In addition to the layer containing mosquito collection points, other map layers were made available including environmental, and vector and pathogen/disease distribution layers. An application within MosquitoMap called the Mal-area calculator (MAC) was constructed to quantify the area of overlap, for any area of interest, of vector, human, and disease distribution models. Data standards for mosquito records were developed for MosquitoMap. MosquitoMap is a public domain web resource that maps and compares georeferenced mosquito collection points to other spatial information, in a geographical information system setting. The MAC quantifies the Mal-area, i.e. the area where it is theoretically possible for vector-borne disease transmission to occur, thus providing a useful decision tool where other disease information is limited. The Mal-area approach emphasizes the independent but cumulative contribution to disease risk of the vector species predicted present. MosquitoMap adds value to, and makes accessible, the results of past collecting efforts, as well as providing a template for other arthropod spatial databases.

  12. A computational fluid dynamics and effectiveness-NTU based co-simulation approach for flow mal-distribution analysis in microchannel heat exchanger headers

    International Nuclear Information System (INIS)

    Huang, Long; Lee, Moon Soo; Saleh, Khaled; Aute, Vikrant; Radermacher, Reinhard

    2014-01-01

    Refrigerant flow mal-distribution is a practical challenge in most microchannel heat exchangers (MCHXs) applications. Geometry design, uneven heat transfer and pressure drop in the different microchannel tubes are three main reasons leading to the flow mal-distribution. To efficiently and accurately account for these three effects, a new MCHX co-simulation approach is proposed in this paper. The proposed approach combines a detailed header simulation based on computational fluid dynamics (CFD) and a robust effectiveness-based finite volume tube-side heat transfer and refrigerant flow modeling tool. The co-simulation concept is demonstrated on a ten-tube MCHX case study. Gravity effect and uneven airflow effect were numerically analyzed using both water and condensing R134a as the working fluids. The approach was validated against experimental data for an automotive R134a condenser. The inlet header was cut open after the experimental data had been collected. The detailed header geometry was reproduced using the proposed CFD header model. Good prediction accuracy was achieved compared to the experimental data. The presented co-simulation approach is capable of predicting detailed refrigerant flow behavior while accurately predicts the overall heat exchanger performance. - Highlights: •MCHX header flow distribution is analyzed by a co-simulation approach. •The proposed method is capable of simulating both single-phase and two-phase flow. •An actual header geometry is reproduced in the CFD header model. •The modeling work is experimentally validated with good accuracy. •Gravity effect and air side mal-distribution are accounted for

  13. Sobre los saberes culturales y el fenómeno "sentirse bien-sentirse mal" On cultural knowledge and the phenomenon "feel good-fell bad"

    Directory of Open Access Journals (Sweden)

    Virtudes Rodero Sánchez

    2010-09-01

    Full Text Available El objetivo del presente estudio es identificar los saberes culturales inmersos en el fenómeno "sentirse-bien, sentirse mal", en diferentes situaciones de cuidado. Se elaboró un estudio cualitativo con un enfoque fenomenológico interpretativo, mediante el análisis de 18 narrativas a partir de entrevistas en profundidad realizadas por alumnas del Máster en Ciencias de la Enfermería en diferentes contextos de cuidados. Las categorías identificadas fueron: (1 Cronicidad y concepto de sentirse bien-sentirse mal. En la cronicidad este concepto está íntimamente relacionado con la recuperación de las actividades de la vida diaria y es componente importante en la percepción individual del concepto "calidad de vida". (2 Momentos agudos de enfermedad y concepto de sentirse bien-sentirse mal. En el análisis de los relatos del paciente aparecieron aspectos esenciales del fenómeno "sentirse bien-sentirse mal" para aumentar la comprensión de aspectos universales de algunos de sus componentes. Destacar que el fenómeno está íntimamente relacionado con la recuperación de las actividades de la vida diaria, y es un mediador importante en la percepción individual del concepto "calidad de vida". El interés de cara al cuidado es distinguir sus componentes universales, contextualizarlos en la práctica, dentro de las singularidades que presenta cada persona, de modo que nos permita su potenciación. El resultado es un cambio en la experiencia sentida.The object of the present study is to identify cultural knowledges immersed in the feeling-well, feeling-bad phenomenon in different care settings. A qualitative study was undertaken using a phenomenological interpretation approach through a meta-analysis of 18 narratives of profound interviews undertaken by Nursing Science Master Degree Students in different care situations. The categories established were: (1 Chronicity and the concept of feeling well-feeling bad. In this category, this concept is

  14. Sobre los saberes culturales y el fenómeno "sentirse bien-sentirse mal" On cultural knowledge and the phenomenon "feel good-fell bad"

    OpenAIRE

    Virtudes Rodero Sánchez; Carme Vives Relats; Sagrario Acebedo Urdiales; Carme Ferré Grau

    2010-01-01

    El objetivo del presente estudio es identificar los saberes culturales inmersos en el fenómeno "sentirse-bien, sentirse mal", en diferentes situaciones de cuidado. Se elaboró un estudio cualitativo con un enfoque fenomenológico interpretativo, mediante el análisis de 18 narrativas a partir de entrevistas en profundidad realizadas por alumnas del Máster en Ciencias de la Enfermería en diferentes contextos de cuidados. Las categorías identificadas fueron: (1) Cronicidad y concepto de sentirse b...

  15. Estudo de dose adequada da droga RO42-1611 (Arteflene) no tratamento da malária por Plasmodium falciparum

    OpenAIRE

    SILVA, Rita do Socorro Uchôa

    1997-01-01

    A resistência crescente do P. falciparum aos antimaláricos habitualmente empregados, torna urgente a avaliação de novas drogas. O Ro 42-1611 é um antimalárico derivado da planta chinesa Arlabotrys uncinatus. Usado apenas na África em três trabalhos no tratamento da malária por P. falciparum, tem sua ação desconhecida em sul-americanos com esta doença. Apesar do efeito antimalárico ter sido comprovado, ainda não se encontrou a dose adequada para o tratamento supressivo do P. falciparum. Avalia...

  16. Mal de Montaña, migraña y depresión: Coexistencia casual o causal? Posible rol de la hipoxia ambiental.

    Directory of Open Access Journals (Sweden)

    Alberto Arregui

    1995-10-01

    Full Text Available Objetivo: Estudiar la posible asociación entre mal de montaña crónico, migraña y depresión. Material y métodos: Estudio epidemiológico realizado en setiembre de 1990en 379 hombres adultos con residencia permanente en la ciudad de Cerro de Pasco (4300 m.s.n.m.; se hicieron 15 preguntas asociadas a depresión y 9 preguntas asociadas al mal de montaña crónico (MMC con las que se calcularon puntajes de depresión y del mal de montaña crónico. Los puntajes por encima de dos desviaciones estándar de la media fueron considerados como altos. Resultados: La frecuencia de migrañas fue de 48.3% entre hombres con puntajes altos de MMC y de 26.5% entre aquellos con puntajes normales (p=0.013. El 16.7% de hombres con puntaje alto de MMC tuvo puntaje alto de depresión mientras que sólo el 6.5% con puntaje normal de MMC tuvo puntaje alto de depresión (p=0.04. El riesgo de tener puntaje alto de depresión o de MMC fue más del doble entre hombres con migrañas comparados con hombres sin migrañas. La posibilidad de tener migraña o puntajes alto de MMC, fue tres veces mayor entre hombres con puntajes alto de depresión comparados con los que tuvieron puntajes de MMC más altos que aquellos sin cefaleas o con otros tipos de cefaleas. Conclusiones: Los datos muestran una coexistencia más que casual entre estas tres entidades clínicas. Se sugiere que un factor de riesgo común a las tres sea la hipoxia crónica que podría producir cambios neuroquímicos en el cerebro que explicaría, en parte, los síntomas de estos tres síndromes. Los datos también sugieren que los síntomas subjetivos que ocurren en el mal de montaña crónico son similares a los que ocurren en la depresión. (Rev Med Hered 1996; 6: 163-167.

  17. Synthesis, crystal structure and magnetic properties of [Cu(mal(abpt(H2O].3/2H2O and [Cu2(sq(abpt 2].2H2O (mal = malonate, sq = squarate, abpt = 4-amino-3,5-di-2-pyridyl-4H-1,2,4 triazole

    Directory of Open Access Journals (Sweden)

    Eno A. Ededet

    2011-04-01

    Full Text Available Two new mixed-ligand complexes of formula [Cu(mal(abpt(H2O].3/2H2O (1 and [Cu2(sq(abpt2].2H2O (2 [mal = malonate, abpt = 4-amino-3,5-di-2-pyridyl-4H-1,2,4 triazole and sq = squarate], have been prepared and characterized by X-ray crystal structure determination and magnetic studies. Complex 1 crystallizes in the monoclinic system, space group C2/c, with a = 14.0086(2 Å, b = 10.0980(2 Å, c = 25.630(4 Å; β = 97.5900(10 o, and Z = 8. Complex 2 crystallizes in the triclinic system, space group P-1 with a = 7.5696(15 Å, b = 8.4697(17 Å, c = 11.049(2 Å; β = 93.00(3o, α = 96.98(3, γ = 90.111(3 and Z = 1. Complex 1 consist of a neutral mononuclear [Cu(mal(abpt(H2O] unit and water molecule of crystallization in a distorted square pyramidal coordination sphere, while complex 2 is viewed as being made up of [Cu(sq(abpt2] units with the squarato ligand bridging the two copper(II cations. Variable temperature magnetic behaviour of the complexes reveals the existence of weak antiferromagnetic interaction for complex 1 and weak ferromagnetic intrachain interaction for complex 2.

  18. Malûliyet

    OpenAIRE

    Güçlü, Eda

    2014-01-01

    Bezmez, Dikmen. “Urban Citizenship, the Right to the City and Politics of Disability in Istanbul.” International Journal of Urban and Regional Research 37, no. 1 (January 2013): 93–114. Evcil, An. “Wheelchair Accessibility to Public Buildings in Istanbul.” Disability & Rehabilitation: Assistive Technology 4, no. 2 (March 2009): 76–85. Evcil, Nilay. “Designers’ Attitudes Towards Disabled People and the Compliance of Public Open Places: The Case of Istanbul.” European Planning Studies 18, no. 1...

  19. Effects of the substitution of iron for cobalt on the crystal and magnetic properties of PrCo4-xFexM (M=Al and Ga)

    International Nuclear Information System (INIS)

    Zlotea, C.; Isnard, O.

    2003-01-01

    We report on the structural and magnetic properties of PrCo 4-x Fe x M where x=0-4 and M=Al and Ga. The iron solubility limit in these phases is determined by means of X-ray diffraction and scanning electron microscopy. Our study confirms that single phase samples crystallizing in the CaCu 5 -type structure are stabilized for x 5 structure but with a slight preference for the 3g site. The saturation magnetization and the Curie temperature increase upon the iron substitution. The PrCo 4-x Fe x M compounds present spin reorientation transitions, whatever the substituting M and the Fe content. The substitution of iron for cobalt induces a significant increase of the spin reorientation temperature. Neutron and X-ray powder diffraction experiments as well as magnetic measurements are combined in order to clarify the effects of the presence of iron on the magnetocrystalline anisotropy and the spin reorientation transition. Finally, the magnetic phase diagrams of PrCo 4-x Fe x M (M=Al and Ga) have been determined in the whole ordered temperature range

  20. Reconciliación de Malí; mayo en Kidal, inflexión en la segunda fase del proceso

    Directory of Open Access Journals (Sweden)

    Juan Carlos Castilla

    2015-01-01

    Full Text Available La reconciliación es uno de los retos de la consolidación de la paz. El ejercicio de la soberanía por parte de las instituciones locales, puede originar diferencias con las organizaciones internacionales durante la transformación del conflicto. El desafío es coordinar estrategias y medidas en el tiempo. El proceso de reconciliación comenzó en Malí con un gobierno de transición. Durante el año 2014, el gobierno ha tratado de impulsar el proceso, en un contexto en el que se han reproducido los enfrentamientos tribales, se han dado nuevos choques entre el MNLA y las Fuerzas Armadas malíes, y dónde sigue influyendo la actividad terrorista yihadista. IBK se refirió a aspectos fundamentales para el futuro inmediato del proceso tras los acontecimientos de mayo en Kidal. Tras estos acontecimientos, las negociaciones de paz se desarrollan con la mediación argelina. La complementariedad entre la justicia nacional y la internacional será una de las claves, lo que a su vez puede interrelacionar con la potencial re-integración futura de excombatientes.

  1. Retardo no crescimento intrauterino, baixo peso ao nascer e prematuridade em recém-nascidos de grávidas com malária, na Colômbia

    Directory of Open Access Journals (Sweden)

    Alberto Tobón-Castaño

    2011-06-01

    Full Text Available INTRODUÇÃO: É frequente a associação da malária com complicações como prematuridade, retardo no crescimento intrauterino, baixo peso ao nascer e mortalidade infantil, efeitos pouco estudados em áreas hipoendêmicas para malaria. O objetivo deste estudo foi analisar a relação da malária gestacional com estes efeitos em recém-nascidosnuma região endêmica para malária na Colômbia, entre 1993 e 2007. MÉTODOS: Foram estudadas as características em 1.716 recém-nascidos num estudo de coorte. Fez-se seguimento em 394 gestantes com malária (27% por Plasmodium falciparum e 73% por P. vivax e 1.322 sem malária. RESULTADOS: Foi encontrada uma relação entre a exposição à malária na gestação e o risco maior de baixo peso ao nascer (RR = 1,37; 1,03-1,83, assim como estatura baixa (RR = 1,52; 1,25-1,85, retardo no crescimento intrauterino (RR = 1,29; 1,0-1,66 e prematuridade (RR = 1,68; 1,3-2,17. A frequência de nascimentos prematuros foi maior nas mães com malária por P. falciparum (77% que aquelas com P. vivax (RR = 1,77; IC 95%: 1,2-2,6. CONCLUSÕES: O baixo peso ao nascer e o retardo no crescimento foi associado com malária na gestação na Colômbia. A infecção por P. vivax foi relacionada com efeitos adversos sobre o recém-nascido, de modo semelhante em relação ao P. falciparum.

  2. Surto de malária induzida entre usuários de drogas injetáveis Outbreak of malaria among injectable-drug users

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Barradas Barata

    1993-02-01

    Full Text Available Em julho de 1990, foi registrado na cidade de Bauru, Estado de São Paulo, Brasil, um surto de malária envolvendo usuários de cocaína injetável. Uma ampla investigação epidemiológica, conduzida de 19 de julho a 13 de setembro, revelou que pelo menos 119 pessoas estavam envolvidas no surto, uma vez que haviam compartilhado seringas e agulhas com um ou mais casos confirmados nos 3 meses anteriores à ocorrência. Cento e duas dessas pessoas foram localizadas e entrevistadas, e destas, 99 foram submetidas a exame de gota espessa e 91 a exames sorológicos para malária. Foram confirmados por exame hemoscópico 21 casos de malária por P. vivax, e 3 outros tiveram exame sorológico positivo para P. vivax. O controle da transmissão foi obtido fornecendo-se cloroquina aos envolvidos no surto, numa dose inicial de 10 comprimidos, seguida de doses supressivas semanais de 2 comprimidos até que fosse identificado o último comunicante. Amostras de soro coletadas na ocasião revelaram, ao lado da malária, uma alta prevalência de infecções pelo HIV (58% e pelo vírus da hepatite B (40%. Foram discutidas as dificuldades para o controle do surto e a possibilidade da malária vir a se tornar uma doença endêmica entre usuários de drogas injetáveis, no Estado de São Paulo.Five cases of malaria were detected among cocaine users by the local health service in Bauru, a city with a population of 260,000, located 324 km from S. Paulo, Brazil, during the first three weeks of July 1990. Autochthonous malaria had not occurred in Bauru since 1978, and all the five cases denied having recently traveled to endemic areas. An extensive epidemiologic survey conducted from July 19 to September 13 revealed that the 5 cases were in fact part of a malaria outbreak among endovenous drug users. Moreover, at least 114 other people, who had in the last three months shared syringes and needles with one or more proved cases, were also involved in the outbreak. One

  3. Malé osobnosti veľkých dejín – veľké osobnosti malých dejín IV. Príspevky k hudobnej regionalistike, Slovenské národné múzeum – Hudobné múzeum, Brämerova kúria, Bratislava 30. listopadu – 1. prosince 2017

    Czech Academy of Sciences Publication Activity Database

    Kachlík, Jan

    2018-01-01

    Roč. 55, č. 1 (2018), s. 102-104 ISSN 0018-7003. [Malé osobnosti veľkých dejín – veľké osobnosti malých dejín IV. Príspevky k hudobnej regionalistike. Bratislava, 30.11.2017-01.12.2017] Institutional support: RVO:68378076 Keywords : music ology * conference Subject RIV: AL - Art, Architecture, Cultural Heritage OBOR OECD: Performing arts studies ( Music ology, Theater science, Dramaturgy)

  4. Malaria infection and the anthropological evolution Infecção por Malária e evolução antropológica

    Directory of Open Access Journals (Sweden)

    Sergio Sabbatani

    2010-03-01

    malária exerceu papel biológico chave, influenciando até o desenvolvimento antropológico. Os Plasmódios causadores da malária desenvolveram dois tipos de evolução, segundo um ponto de vista biológico, e filogenético. Em particular, os Plasmódios vivax, malariae, e ovale poderiam ter coevoluído com a espécie humana ou ter atingido esta durante as fases mais antigas da evolução do gênero HOMO. Por outro lado, o Plasmódio falciparum teria sido transmitido aos humanos por macacos num período mais recente, provavelmente entre o fim da Idade Mesolítica e o início da Neolítica. Os Autores mostram evidências biomoleculares, tanto diretas como indiretas, de infecção por malária, observada em indivíduos enterrados, reportando ao Mundo Antigo, e trazidas à luz no decorrer de escavações arqueológicas em alguns sítios relevantes Mediterrâneos. Nesta revisão da literatura, os autores organizam evidências modernas. Confirmam o papel da malária ao afetar a evolução das populações no Mediterrâneo. As pessoas que moram nas várias regiões do Mediterrâneo foram progressivamente influenciadas pela malária, ao longo do avanço desta doença. Além disso, as populações afetadas desenvolveram adaptações culturais, alimentares, e de comportamento, contribuindo para uma redução no risco da doença. Entretanto, pode ser que ambas modificações (as biológicas e as dos hábitos usadas pelos Plasmódios da malária, favoreceram a emergência de grupos de pessoas com maior resistência contra a malária. Todos estes fatores considerados reduziram o impacto demográfico, influenciando de uma maneira favorável o desenvolvimento em geral, e o crescimento da civilização.

  5. Nanotecnologia farmacêutica aplicada ao tratamento da malária Application of pharmaceutical nanotechnology to the treatment of malaria

    Directory of Open Access Journals (Sweden)

    Lúcio Figueira Pimentel

    2007-12-01

    Full Text Available Apesar do desenvolvimento tecnológico e científico, a malária permanece como um dos maiores problemas de saúde a serem combatidos. As estratégias modernas para o controle da doença prevêem ações conjuntas, como o combate do inseto vetor, diagnóstico rápido e preciso, garantia de terapêutica adequada, redução dos casos de resistência, além do desenvolvimento de novos agentes terapêuticos e vacina e através da otimização da ação de fármacos utilizados na atualidade. Os sistemas de liberação controlada de fármacos vêm recebendo atenção especial nesta área de pesquisa, com o desenvolvimento de estratégias para a veiculação de agentes bioativos e vacinas na forma de nanodispositivos tais como lipossomas, nanopartículas e micropartículas. Diversos nanossistemas já demonstraram eficácia na otimização de vacinas e quimioterápicos destinados ao controle da malária. Este artigo de revisão tem por objetivo avaliar o estado da arte na terapêutica da malária e demonstrar o potencial da nanotecnologia farmacêutica como ferramenta destinada ao combate da doença.In spite of living in a scientific and technological era, malaria continues to be one of the worldwide greatest health challenges. The state-of-the-art policy to keep malaria under control is expected to comprise joint-strategies, such as the vector control, fast diagnosis, therapeutic guarantee, resistance cutback, drug optimization and development of new therapeutic agents and vaccines. Nano and microcarrier systems have been receiving a special attention, including the development of strategies for carrying bioactive agents, vaccines through nanodevices, such as liposomes and nanoparticles, and microdevices, such as microparticles and microemulsions. Numerous nanosystems have already substantiated their effectiveness to optimize vaccines, insecticides, and chemotherapeutic agents applied to the control of malaria. This review is intended to explain the

  6. DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer

    International Nuclear Information System (INIS)

    Kalmár, Alexandra; Péterfia, Bálint; Hollósi, Péter; Galamb, Orsolya; Spisák, Sándor; Wichmann, Barnabás; Bodor, András; Tóth, Kinga; Patai, Árpád V.; Valcz, Gábor; Nagy, Zsófia Brigitta; Kubák, Vivien; Tulassay, Zsolt; Kovalszky, Ilona; Molnár, Béla

    2015-01-01

    Colorectal cancer (CRC) development is accompanied by changes in expression for several genes; but the details of the underlying regulatory procesess remain unknown. Our aims were to assess the role of epigenetic processes in tumour formation and to identify characteristic DNA methylation and miRNA alterations in the colorectal adenoma-carcinoma sequence. Whole genome expression profiling was performed on colonic biopsy samples (49 healthy normal, 49 colorectal adenoma (AD), 49 CRC); on laser capture microdissected (LCM) epithelial and stromal cells from 6 CRC-normal adjacent tissue (NAT) samples pairs, and on demethylated human CRC cell lines using HGU133 Plus 2.0 microarrays (Affymetrix). Methylation status of genes with gradually altering expression along the AD-CRC sequence was further analysed on 10–10 macrodissected and 5–5 LCM samples from healthy colon, from adenoma and from CRC biopsy samples using bisulfite-sequencing PCR (BS-PCR) followed by pyrosequencing. In silico miRNA prediction for the selected genes was performed with miRWALK algorithm, miRNA expression was analysed on 3 CRC-NAT sample pairs and 3 adenoma tissue samples using the Human Panel I + II (Exiqon). SFRP1 immunohistochemistry experiments were performed. A set of transcripts (18 genes including MAL, SFRP1, SULT1A1, PRIMA1, PTGDR) showed decreasing expression (p < 0.01) in the biopsy samples along the adenoma-carcinoma sequence. Three of those (COL1A2, SFRP2, SOCS3) showed hypermethylation and THBS2 showed hypomethylation both in AD and in CRC samples compared to NAT, while BCL2, PRIMA1 and PTGDR showed hypermethylation only in the CRC group. miR-21 was found to be significantly (p < 0.01) upregulated in adenoma and tumour samples compared to the healthy colonic tissue controls and could explain the altered expression of genes for which DNA methylation changes do not appear to play role (e.g. BCL2, MAL, PTGS2). Demethylation treatment could upregulate gene expression of genes that were

  7. Algoritmo para monitoramento da incidência da malária na Amazônia brasileira, 2003 a 2010

    Directory of Open Access Journals (Sweden)

    Rui Moreira Braz

    2014-03-01

    Full Text Available OBJETIVO: Avaliar um algoritmo para detecção da variação da incidência da malária nos municípios da Amazônia brasileira. MÉTODOS: Avaliou-se um sistema de monitoramento automatizado, baseado em um algoritmo desenvolvido anteriormente pelos autores. O algoritmo utiliza o diagrama de controle por quartis para classificação dos municípios em quatro grupos, conforme a variação da incidência da malária: grupo 1 (redução da incidência-aqueles com incidência abaixo dos valores esperados; grupo 2 (incidência esperada-aqueles com incidência dentro dos valores esperados; grupo 3 (epidemia-aqueles com incidência acima dos valores esperados; grupo 4 (caso esporádico-aqueles com apenas um caso durante o ano. O período de análise foi de 2003 a 2010. Foram estudados todos os municípios existentes nos nove estados que compõem a Amazônia brasileira (805 municípios em 2003 e 807 a partir de 2004. RESULTADOS: Com base nessa metodologia, os municípios da região foram assim classificados: grupo 1, 152 municípios (18,8% da região em 2003 e 109 (13,5% em 2010; grupo 2, 206 (25,6% em 2003 e 331 (41,0% em 2010; grupo 3, 391 (48,6% em 2003 e 308 (38,2% em 2010; e grupo 4, 56 (7,0% em 2003 e 59 (7,3% em 2010. CONCLUSÕES: O algoritmo possibilitou verificar que, na Amazônia brasileira, o número de municípios com epidemias de malária em 2010 diminuiu em relação a 2003, enquanto o número de municípios com incidência esperada aumentou. No mesmo período, houve pouca variação no número de municípios com redução da incidência e daqueles com casos esporádicos.

  8. A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling.

    NARCIS (Netherlands)

    Nagpal, K.; Plantinga, T.S.; Wong, J.; Monks, B.G.; Gay, N.J.; Netea, M.G.; Fitzgerald, K.A.; Golenbock, D.

    2009-01-01

    The adapter protein MyD88 adapter-like (Mal), encoded by TIR-domain containing adapter protein (Tirap) (MIM 606252), is the most polymorphic of the five adapter proteins involved in Toll-like receptor signaling, harboring eight non-synonymous single nucleotide polymorphisms in its coding region. We

  9. Debata o památkové péči v 60. letech 20. století. Ivo Loos, Jindřich Malátek a Transgas

    Czech Academy of Sciences Publication Activity Database

    Švácha, Rostislav

    2017-01-01

    Roč. 77, č. 4 (2017), s. 361-372 ISSN 1210-5538 Institutional support: RVO:68378033 Keywords : Jindřich Malátek * Ivo Loos * postwar architecture * theory of architecture and heritage care * Transgas Subject RIV: AL - Art, Architecture, Cultural Heritage

  10. Realezas entre o bem e o mal: as representações de monarcas nas páginas da Marvel Comics

    OpenAIRE

    Guerra, Fábio Vieira

    2016-01-01

    Este trabalho propõe analisar três das monarquias apresentadas nas narrativas da editora americana de quadrinhos Marvel Comics. Essas histórias têm como protagonistas seres com habilidades extraordinárias chamados de super-heróis. Pautados em uma disputa dualista entre o Bem e o Mal, os quadrinhos de super-heróis são expressão de um imaginário coletivo sobre a nação estadunidense e os valores que norteiam sua organização social e suas ações no mundo. Desse modo, a representação de outros país...

  11. Pensamentos, sentimentos, vontades e afetos: a fisio-psicologia de Nietzsche a partir do aforismo 19 de Para Além de Bem e Mal

    Directory of Open Access Journals (Sweden)

    Bruno Martins Machado

    2011-05-01

    Full Text Available O presente estudo busca apresentar como a noçáo de fisio-psicologia proposta por Nietzsche se estrutura sobre o corpo e exige uma alteraçáo particular na determinaçáo da noçáo de vontade. Para realizar tal empreendimento, tomamos como parâmetro principalmente o aforismo 19 de Para Além de Bem e Mal. Neste texto, Nietzsche apresenta uma releitura da noçáo de vontade a partir da análise da estrutura dos afetos, dos pensamentos e dos sentimentos. A importância desse empreendimento se justifica por abrir espaço para uma proposta psicológica baseada em um dinamismo que está para além dos processos conscientes.

  12. Teste de hemaglutinação na sorologia da malária humana empregando hemácias parasitadas pelo Plasmodium berghei

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    Maria Carmen Arroyo Sanchez-Ruiz

    1985-06-01

    Full Text Available Foi padronizado um teste de hemaglutinação para a sorologia da malária humana, com reagente constituído de suspensão de hemácias de camundongos infectadas pelo Plasmodium berghei e preservadas por fixação aldeídica. Em pacientes com parasitemia por P. falciparum ou P. vivax obteve-se uma sensibilidade de 98,9% nos 88 casos estudados, o teste apresentando títulos entre 40 e 640. Para o grupo de 476 soros de indivíduos não-maláricos, obteve-se uma especificidade de 96,0%. O teste apresentou elevada reprodutibilidade, mesmo para diferentes lotes de antígenos. Nos 200 soros, obtidos ao acaso, de indivíduos de área endêmica, o teste apresentou positividade de 48,5%, contra 88,0% do teste de imunofluorescência-IgG. A baixa positividade pode ser devida a que o teste de hemaglutinação detecta anticorpos IgM. Após tratamento com 2-mercaptoetanol, todos os soros de pacientes com parasitemia tornaram-se não reagentes. Em relação ao teste de imunofluorescência-IgG, o teste de hemaglutinação apresentou índice de co-positívidade de 0,989 para os soros de maláricos com parasitemia. Para os soros de não-maláricos o teste de hemaglutinação apresentou índice de co-negatividade de 0,969. Por outro lado, no grupo de soros de área endêmica, o índice de co-positividade foi de 0,528 e o de co-negatividade, de 0,833.A hemagglutination test is described for human malaria serodiagnosis with aldehyde-fixed Plasmodium berghei infected mouse erythrocytes. In patients with a P. falciparum or P. vivax patent parasitemia positive results were seen in 98.9% ofthe 88 cases tested. Titres rangedfrom 40 to 640. A 96.0% specificity wasfoundfor 476 non-malarialpatients. A close reproducibility was observed forthe test, even for dijferent reagent batches. The test was positive in 48.5% of 200 residents in malaria endemic areas, taken at random. These subjects showed 88.0% positivity of the IgG-immunofluorescence test. This lower positivity for

  13. Causas mal definidas de morte e óbitos sem assistência Ill-defined causes of death and unattended deaths, Brazil, 2003

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    Augusto Hasiak Santo

    2008-02-01

    Full Text Available OBJETIVOS: Este trabalho estuda a distribuição dos óbitos por causas mal definidas no Brasil, no ano de 2003, entre as quais identifica a proporção de mortes sem assistência. MÉTODOS: Os dados provieram do Sistema de Informações Sobre Mortalidade, coordenado pelo Ministério da Saúde. As causas mal definidas de morte compreenderam as incluídas no "Capítulo XVIII - Sintomas, sinais e achados anormais de exames clínicos e de laboratório não classificados em outra parte" da Classificação Estatística Internacional de Doenças e Problemas Relacionados à Saúde, décima revisão, capítulo este no qual a categoria R98 identificava a "morte sem assistência". RESULTADOS: No Brasil, em 2003, a causa básica de 13,3% dos óbitos foi identificada como mal definida, sendo que as proporções maiores ocorreram nas Regiões Nordeste e Norte. Do total de causas mal definidas no país, 53,3% corresponderam a mortes sem assistência, proporção esta que superou 70% nos Estados do Maranhão, Piauí, Rio Grande do Norte, Pernambuco, Bahia, Paraíba e Alagoas. CONCLUSÃO: Dada a estrutura descentralizada para o levantamento dos óbitos no país, identifica-se a maior responsabilidade dos municípios e, em seguida, dos Estados para o aprimoramento da qualidade das estatísticas de mortalidade.BACKGROUND: We studied the distribution of deaths from ill-defined causes that occurred in Brazil during 2003, from which was identified the proportion of unattended deaths. METHODS: Data were obtained from the Mortality Information System, coordinated by the Ministry of Health. Causes of death included in "Chapter XVIII - Symptoms, signs and abnormal clinical and laboratory findings, not classified elsewhere" of the International Statistical Classification of Diseases and Related Health Problems, tenth revision, were considered ill-defined, among which the category R98 identified "unattended deaths". RESULTS: In Brazil during 2003 the underlying causes of

  14. Reposição cirúrgico-ortopédica de implante mal posicionado: relato de caso Surgical-orthopedic repositioning of malpositioned implant: a case report

    Directory of Open Access Journals (Sweden)

    Luiz Carlos Ferreira da Silva

    2005-06-01

    Full Text Available A reabilitação bucal por meio da colocação de implantes dentários tem se tornado um procedimento freqüente da clínica odontológica. Falhas no planejamento ou na execução da técnica podem levar a casos onde, apesar de osseointegrado, o implante não apresenta condições de restauração satisfatória devido ao seu mal posicionamento. Diversos autores têm relatado a possibilidade de se utilizar osteotomias segmentares de maxila ou mandíbula para reposicionar um segmento alveolar com implante, mostrando que esta pode ser uma técnica efetiva e previsível para restaurar implantes em posição anatômica comprometida. O presente trabalho apresenta o caso clínico de uma paciente de 20 anos de idade onde foi realizada osteotomia segmentar de maxila associada à distração osteogênica para correção de um implante mal posicionado.Oral rehabilitation through dental implants has become a common procedure at dental practice. However, if the implant is placed in an inappropriate position either because of inadequate presurgical planning or poor surgical technique, it may be unrestorable in spite of osseointegrated. Many authors have reported the possibility of using segmental maxillary or mandibular osteotomies to reposition an alveolar segment with its implants. This can be an effective, predictable technique for restoring implants in a compromised anatomic position. This paper presents a case report describing the use of this procedure associated to distraction osteogeneis to reposition one malpositioned implant in a 20 years old girl.

  15. Correction of vitamin D deficiency using sublingually administered vitamin D2 in a Crohn's disease patient with mal-absorption and a new ileostomy.

    Science.gov (United States)

    McCullough, Patrick; Heaney, Robert

    2017-10-01

    Vitamin D deficiency has been shown to be associated with many adverse health problems. Studies have shown that patients with Crohn's disease who have low vitamin D levels have a poorer quality of life than those with more adequate levels. It has also been shown that patients with mal-absorption problems have a difficult time achieving normal vitamin D levels in spite of aggressive supplementation, and that exposure to UVB radiation may be the most effective treatment option for these patients. We present a case in which 25-hydroxyvitamin D levels were normalized within 2 weeks in a severely vitamin D deficient patient with Crohn's disease with mal-absorption and a new ileostomy, utilizing sublingually administered vitamin D2. A 58 year-old white female was admitted with a new ileostomy following partial bowel resection due to complications from Crohn's disease. She was found to be severely vitamin D deficient at the time of admission, with a level of 6.1ng/ml on hospital day 3. Her treatment with vitamin D was delayed for a few days. She was initially treated with 5000 units of vitamin D3 orally twice a day for 3days (days 7-10). After discussion with the patient and obtaining her consent, vitamin D3 was stopped, and she was then treated with a total of 8 doses of 50,000 units of vitamin D2 administered sublingually. She was given the first 3 doses on alternating days (days 11, 13, 15), and then 5 more doses on consecutive days (days 17-21). The rise in her 25-hydroxyvitamin D level in response to treatment with sublingual vitamin D2 was significant. On day 10, after receiving 3days of orally administered vitamin D3, her level was 9.8ng/ml. One week later, after receiving 3 sublingual doses of vitamin D2, it rose to 20.3ng/ml. It was then measured on alternating days twice over the next 4days, and it rose to 45.5ng/ml, and then to 47.4ng/ml on the day of discharge to home. The major finding of this study is that sublingual administration of vitamin D2 appears to

  16. Mal de Pott en pediatría: presentación de 5 casos y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    Gladys Abreu Suárez

    2002-09-01

    Full Text Available Se presentan 5 de los 6 niños afectados de mal de Pott en el período de 1995 a 2001, para una incidencia del 4,5 % del total de casos de tuberculosis infantil en Cuba. La mayoría de los niños tenía alrededor de 2 años de edad, con un predominio de la afectación lumbar en 4 pacientes. El cuadro clínico fue insidioso, y fueron más frecuentes el dolor de espalda y los trastornos a la marcha. El diagnóstico fue clinicorradiológico, y la tuberculina positiva en 4 niños. Sólo se aisló Micobacterium tuberculosis en un paciente, en el que concomitaban lesiones pulmonares. En 3 enfermos se hallaron abscesos paravertebrales (2 en la región dorsal, y el otro en el psoas. Aún se encuentran 3 pacientes en tratamiento; de los 2 curados, uno tiene pérdida de la lordosis fisiológica lumbar, y otro perdió un cuerpo vertebral con una giba residual ligera. Se concluye que, aunque la tuberculosis infantil no es un problema de salud en Cuba, y el mal de Pott no es frecuente, debe tenerse en cuenta ante un niño pequeño que se consulte con manifestaciones insidiosas de trastornos de la marcha y dolor de espalda.5 of the 6 children affected by Pott’s disease from 1995 to 2001 are presented in this paper for an incidence of 4.5 % of the total of cases of infantile tuberculosis in Cuba. Most of the children were about 2 years old. A predominance of lumbar affection was observed in 4 patients. The clinical picture was insidious and back pain and walking disorders were more frequent. The diagnosis was clinicoradiological and tuberculin was positive in 4 children. Micobacterium tuberculosis was only isolated from a patient with concomitant pulmonary injuries. Paravertebral abscesses (2 in the dorsal region and the other in the psoas were found in 3 patients. There are still 3 patients under treatment: one of the two that were cured suffers from loss of the physiological lumbar lordosis and the other lost a vertebral body and presents a mild residual

  17. Co-expression of the Thermotoga neapolitana aglB gene with an upstream 3'-coding fragment of the malG gene improves enzymatic characteristics of recombinant AglB cyclomaltodextrinase.

    Science.gov (United States)

    Lunina, Natalia A; Agafonova, Elena V; Chekanovskaya, Lyudmila A; Dvortsov, Igor A; Berezina, Oksana V; Shedova, Ekaterina N; Kostrov, Sergey V; Velikodvorskaya, Galina A

    2007-07-01

    A cluster of Thermotoga neapolitana genes participating in starch degradation includes the malG gene of sugar transport protein and the aglB gene of cyclomaltodextrinase. The start and stop codons of these genes share a common overlapping sequence, aTGAtg. Here, we compared properties of expression products of three different constructs with aglB from T. neapolitana. The first expression vector contained the aglB gene linked to an upstream 90-bp 3'-terminal region of the malG gene with the stop codon overlapping with the start codon of aglB. The second construct included the isolated coding sequence of aglB with two tandem potential start codons. The expression product of this construct in Escherichia coli had two tandem Met residues at its N terminus and was characterized by low thermostability and high tendency to aggregate. In contrast, co-expression of aglB and the 3'-terminal region of malG (the first construct) resulted in AglB with only one N-terminal Met residue and a much higher specific activity of cyclomaltodextrinase. Moreover, the enzyme expressed by such a construct was more thermostable and less prone to aggregation. The third construct was the same as the second one except that it contained only one ATG start codon. The product of its expression had kinetic and other properties similar to those of the enzyme with only one N-terminal Met residue.

  18. la originalidad del regionalismo castellano y leonés en 1931 y 1932. ¿Un proyecto genuino o la necesidad de asumir un mal menor?

    Directory of Open Access Journals (Sweden)

    Luis Felipe PALACIOS

    2016-05-01

    Full Text Available Entre 1931 y 1932, como ocurrió en otras regiones españolas, Castilla y León asistió al resurgir de un regionalismo que hasta la fecha apenas había dado síntomas de vitalidad. A partir de esta realidad la pregunta que surge es si la renovada actividad regionalista castellano y leonesa reflejaba la actualización de un sentir originario y bien arraigado o era una respuesta obligada por el avance que estaba logrando el catalanismo durante el período considerado y por el nuevo modelo de organización territorial del Estado que definió la nueva Constitución de 1931. A la vista del comportamiento y manifestaciones de las fuerzas políticas, sociales e institucionales castellano y leonesas, podemos concluir que el regionalismo castellano y leonés no respondió a un sentimiento genuino y propio sino que fue la consecuencia de la necesidad de asumir un mal menor, de la adaptación a un nuevo modelo territorial no deseado.

  19. In vivo subcellular localization of Mal de Rio Cuarto virus (MRCV) non-structural proteins in insect cells reveals their putative functions

    Energy Technology Data Exchange (ETDEWEB)

    Maroniche, Guillermo A.; Mongelli, Vanesa C.; Llauger, Gabriela; Alfonso, Victoria; Taboga, Oscar [Instituto de Biotecnologia, CICVyA, Instituto Nacional de Tecnologia Agropecuaria (IB-INTA), Las cabanas y Los Reseros s/n. Hurlingham Cp 1686, Buenos Aires (Argentina); Vas, Mariana del, E-mail: mdelvas@cnia.inta.gov.ar [Instituto de Biotecnologia, CICVyA, Instituto Nacional de Tecnologia Agropecuaria (IB-INTA), Las cabanas y Los Reseros s/n. Hurlingham Cp 1686, Buenos Aires (Argentina)

    2012-09-01

    The in vivo subcellular localization of Mal de Rio Cuarto virus (MRCV, Fijivirus, Reoviridae) non-structural proteins fused to GFP was analyzed by confocal microscopy. P5-1 showed a cytoplasmic vesicular-like distribution that was lost upon deleting its PDZ binding TKF motif, suggesting that P5-1 interacts with cellular PDZ proteins. P5-2 located at the nucleus and its nuclear import was affected by the deletion of its basic C-termini. P7-1 and P7-2 also entered the nucleus and therefore, along with P5-2, could function as regulators of host gene expression. P6 located in the cytoplasm and in perinuclear cloud-like inclusions, was driven to P9-1 viroplasm-like structures and co-localized with P7-2, P10 and {alpha}-tubulin, suggesting its involvement in viroplasm formation and viral intracellular movement. Finally, P9-2 was N-glycosylated and located at the plasma membrane in association with filopodia-like protrusions containing actin, suggesting a possible role in virus cell-to-cell movement and spread.

  20. Linfoma Nasal de Células T/Natural Killer Extranodal Refractario Mal Diagnosticado, Tratado de Manera Exitosa: Informe de Caso.

    Science.gov (United States)

    Saavedra Ramírez, José Domingo

    2017-01-01

    El linfoma de células T/natural killer extranodal ("extranodal natural killer/T-cell lymphoma", ENKL) nasal es un linfoma no Hodgkin (LNH) agresivo y poco común para el cual no se ha establecido un tratamiento de referencia claro, especialmente en el escenario de la enfermedad recidivante/refractaria. Debido a su rareza, no se han llevado a cabo ensayos aleatorizados específicamente en ENKL nasal; sin embargo, los informes de caso y las series de caso pequeñas ofrecen un conocimiento importante sobre nuevos tratamientos potenciales. Presentamos el informe de caso de un paciente con ENKL nasal (previamente mal diagnosticado como una sinusitis crónica recidivante) en quien la enfermedad progresó durante la quimioterapia con múltiples agentes pero respondió al tratamiento de segunda línea con pralatrexato como agente único. Analizamos opciones de tratamiento para el ENKL nasal recidivante/refractario y sugerimos que el pralatrexato se evalúe más a fondo en este escenario clínico.

  1. The etiology, risk factors, and interactions of enteric infections and malnutrition and the consequences for child health and development study (MAL-ED): description of the Tanzanian site.

    Science.gov (United States)

    Mduma, Estomih R; Gratz, Jean; Patil, Crystal; Matson, Kristine; Dakay, Mary; Liu, Sarah; Pascal, John; McQuillin, Lauren; Mighay, Emmanuel; Hinken, Elizabeth; Ernst, Alexandra; Amour, Caroline; Mvungi, Regisiana; Bayyo, Eliwaza; Zakaria, Yeconia; Kivuyo, Sokoine; Houpt, Eric R; Svensen, Erling

    2014-11-01

    The Haydom, Tanzania, site (TZH) of The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) Study is in north-central Tanzania, 300 km from the nearest urban center. TZH is in a remote rural district where most of the population are agropastoralists and grow maize as the staple food. The average household size is 7. The average woman achieves a parity of 6 and has 1 child death. Socioeconomic indicators are poor, with essentially no household having access to electricity, piped water, or improved sanitary facilities (compared with 14%, 7%, and 12%, respectively, reported nationally). The Demographic Health Survey Tanzania 2004 indicated that the region had high rates of stunting and underweight (40% and 31% of children aged child mortality rate of 5.8%. Human immunodeficiency virus prevalence among 18-month-old children is rural African population with profound poverty and malnutrition, but a strong community-based research infrastructure. © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  2. INTERVENCIÓN FAMILIAR PARA EL MANEJO PSICOLÓGICO EN PACIENTES ONCOLÓGICOS CON MAL PRONÓSTICO EN EL HOSPITAL DE LA MISERICORDIA

    Directory of Open Access Journals (Sweden)

    Martha Restrepo Forero

    2004-06-01

    Full Text Available Se diseñó un programa fundamentado en el modelo cognitivo conductual de Inoculación de Estrés e intervención en duelo anticipatorio basado en cuatro tareas. El programa fue aplicado a tres pacientes con mal pronóstico del Servicio de Oncohematología del Hospital de la Misericordia y a sus familias. Por medio de estudio de caso, se describieron factores de riesgo y de protección así como respuestas frente a dicha intervención. El análisis cualitativo de casos arrojó la descripción de respuestas a pérdidas previas no elaboradas, pautas de comunicación deficiente en uno de los casos, y reconocimiento de apoyo al interior de cada familia. Según el reporte de los participantes, la intervención permitió la expresión de sentimientos, la reflexión sobre el sentido de la vida, incremento de posibilidades y habilidades de comunicación y orientación hacia la solución de problemas y toma de decisiones.

  3. Caminhos de um mal-estar de civilização: reflexões intelectuais norte-americanas para pensar a democracia e o negro no Brasil

    Directory of Open Access Journals (Sweden)

    Elizabeth Cancelli

    2010-05-01

    Full Text Available

    Este trabalho tem como objetivo buscar eixos de reflexão desenvolvidos nos Estados Unidos e que foram importantes para repensar a questão da democracia e da cultura no Brasil, especialmente no que diz respeito à inclusão social do negro e à construção de uma identidade brasileira. Assim, as releituras da herança da escravidão verificadas no Sul norte-americano nas primeiras décadas do século XX e o encorajamento para a redefinição da democracia, ocorridos no auge da guerra fria e da cultural war, serão contemplados para a recuperação de vertentes importantes do pensamento brasileiro e sua inserção nos debates em torno desse “mal-estar de civilização”.

  4. Mal de Río Cuarto Virus Infection Triggers the Production of Distinctive Viral-Derived siRNA Profiles in Wheat and Its Planthopper Vector.

    Science.gov (United States)

    de Haro, Luis A; Dumón, Analía D; Mattio, María F; Argüello Caro, Evangelina Beatriz; Llauger, Gabriela; Zavallo, Diego; Blanc, Hervé; Mongelli, Vanesa C; Truol, Graciela; Saleh, María-Carla; Asurmendi, Sebastián; Del Vas, Mariana

    2017-01-01

    Plant reoviruses are able to multiply in gramineae plants and delphacid vectors encountering different defense strategies with unique features. This study aims to comparatively assess alterations of small RNA (sRNA) populations in both hosts upon virus infection. For this purpose, we characterized the sRNA profiles of wheat and planthopper vectors infected by Mal de Río Cuarto virus (MRCV, Fijivirus, Reoviridae ) and quantified virus genome segments by quantitative reverse transcription PCR We provide evidence that plant and insect silencing machineries differentially recognize the viral genome, thus giving rise to distinct profiles of virus-derived small interfering RNAs (vsiRNAs). In plants, most of the virus genome segments were targeted preferentially within their upstream sequences and vsiRNAs mapped with higher density to the smaller genome segments than to the medium or larger ones. This tendency, however, was not observed in insects. In both hosts, vsiRNAs were equally derived from sense and antisense RNA strands and the differences in vsiRNAs accumulation did not correlate with mRNAs accumulation. We also established that the piwi-interacting RNA (piRNA) pathway was active in the delphacid vector but, contrary to what is observed in virus-infected mosquitoes, virus-specific piRNAs were not detected. This work contributes to the understanding of the silencing response in insect and plant hosts.

  5. Omitted Arguments and Complexity of Predication

    Science.gov (United States)

    Port, Martin

    2010-01-01

    This work focuses on the licensing conditions and logical structure of understood-argument constructions, or complement-drop constructions, in English. There are two main types of such arguments: Indefinite Understood Arguments (IUA) and Definite Understood Arguments (DUA). IUA readings occur in such cases in "He ate, He cooked". In such cases,…

  6. RAPTOR: Ransomware Attack PredicTOR

    OpenAIRE

    Quinkert, Florian; Holz, Thorsten; Hossain, KSM Tozammel; Ferrara, Emilio; Lerman, Kristina

    2018-01-01

    Ransomware, a type of malicious software that encrypts a victim's files and only releases the cryptographic key once a ransom is paid, has emerged as a potentially devastating class of cybercrimes in the past few years. In this paper, we present RAPTOR, a promising line of defense against ransomware attacks. RAPTOR fingerprints attackers' operations to forecast ransomware activity. More specifically, our method learns features of malicious domains by looking at examples of domains involved in...

  7. A coronagraph for operational space weather predication

    Science.gov (United States)

    Middleton, Kevin F.

    2017-09-01

    Accurate prediction of the arrival of solar wind phenomena, in particular coronal mass ejections (CMEs), at Earth, and possibly elsewhere in the heliosphere, is becoming increasingly important given our ever-increasing reliance on technology. The potentially severe impact on human technological systems of such phenomena is termed space weather. A coronagraph is arguably the instrument that provides the earliest definitive evidence of CME eruption; from a vantage point on or near the Sun-Earth line, a coronagraph can provide near-definitive identification of an Earth-bound CME. Currently, prediction of CME arrival is critically dependent on ageing science coronagraphs whose design and operation were not optimized for space weather services. We describe the early stages of the conceptual design of SCOPE (the Solar Coronagraph for OPErations), optimized to support operational space weather services.

  8. Transmisión del Mal de Río Cuarto virus por ninfas de primer y tercer estadio de Delphacodes kuscheli Transmission of Mal de Río Cuarto virus by first and third-instar nymphs of Delphacodes kuscheli

    Directory of Open Access Journals (Sweden)

    Joel Arneodo

    2005-02-01

    Full Text Available Se comparó la capacidad de ninfas de primer y tercer estadío de Delphacodes kuscheli Fennah (Hemiptera: Delphacidae para adquirir y posteriormente transmitir el Mal de Río Cuarto virus (MRCV, bajo condiciones controladas. Ninfas I y III avirulíferas se alimentaron separadamente de plantas de trigo infectadas durante 48 horas, para luego ser colocadas en subgrupos de tres individuos sobre plantas de trigo sanas. Se realizaron transmisiones seriales utilizando períodos de inoculación de 24 horas. Ambos estadií os lograron adquirir y transmitir el MRCV, pero se evidenció una mayor cantidad de subgrupos infectivos cuando la adquisición se efectuó como ninfas I, así como una disminución significativa en la duración del período de latencia del virus respecto de los insectos que adquirieron el MRCV durante el tercer estadio ninfal.The ability of first and third-instar Delphacodes kuscheli Fennah (Hemiptera: Delphacidae nymphs to acquire and transmit Mal de Río Cuarto virus (MRCV, under controlled conditions, was investigated. First and third-instar nymphs were allowed acquisition feeding separately on infected wheat plants for 48 hours. The insects were then placed in groups of three for serial transmissions to healthy wheat plants, using inoculation periods of 24 hours. Both instars of D. kuscheli were demonstrated to acquire and subsequently transmit the virus. Nevertheless, transmission trials showed highest transmission efficiency and shortest latent period when MRCV was acquired by first-instar nymphs.

  9. Dynamics and Trends in Fecal Biomarkers of Gut Function in Children from 1–24 Months in the MAL-ED Study

    Science.gov (United States)

    McCormick, Benjamin J. J.; Lee, Gwenyth O.; Seidman, Jessica C.; Haque, Rashidul; Mondal, Dinesh; Quetz, Josiane; Lima, Aldo A. M.; Babji, Sudhir; Kang, Gagandeep; Shrestha, Sanjaya K.; Mason, Carl J.; Qureshi, Shahida; Bhutta, Zulfiqar A.; Olortegui, Maribel Paredes; Yori, Pablo Peñataro; Samie, Amidou; Bessong, Pascal; Amour, Caroline; Mduma, Estomih; Patil, Crystal L.; Guerrant, Richard L.; Lang, Dennis R.; Gottlieb, Michael; Caulfield, Laura E.; Kosek, Margaret N.

    2017-01-01

    Growth and development shortfalls that are disproportionately prevalent in children living in poor environmental conditions are postulated to result, at least in part, from abnormal gut function. Using data from The Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) longitudinal cohort study, we examine biomarkers of gut inflammation and permeability in relation to environmental exposures and feeding practices. Trends in the concentrations of three biomarkers, myeloperoxidase (MPO), neopterin (NEO), and α-1-antitrypsin (AAT), are described from fecal samples collected during the first 2 years of each child's life. A total of 22,846 stool samples were processed during the longitudinal sampling of 2,076 children 0–24 months of age. Linear mixed models were constructed to examine the relationship between biomarker concentrations and recent food intake, symptoms of illness, concurrent enteropathogen infection, and socioeconomic status. Average concentrations of MPO, NEO, and AAT were considerably higher than published references for healthy adults. The concentration of each biomarker tended to decrease over the first 2 years of life and was highly variable between samples from each individual child. Both MPO and AAT were significantly elevated by recent breast milk intake. All three biomarkers were associated with pathogen presence, although the strength and direction varied by pathogen. The interpretation of biomarker concentrations is subject to the context of their collection. Herein, we identify that common factors (age, breast milk, and enteric infection) influence the concentration of these biomarkers. Within the context of low- and middle-income communities, we observe concentrations that indicate gut abnormalities, but more appropriate reference standards are needed. PMID:27994110

  10. Malófagos (Phthiraptera, Amblycera, Ischnocera em aves cativas no sudeste do Brasil Chewing lice (Phthiraptera, Amblycera, Ischnocera on captive birds in southeastern Brazil

    Directory of Open Access Journals (Sweden)

    Salete Oliveira da Silva

    2009-01-01

    Full Text Available Foram identificadas 12 espécies de malófagos no Parque Zoológico Municipal Quinzinho de Barros, Sorocaba e Fundação Jardim Zoológico, Rio de Janeiro. Ciconiphilus pectiniventris em Cygnus atratus (Anseriformes, Anatidae; Kurodaia sp. em Buteo albicaudatus (Falconiformes, Accipitridae; Degeeriella sp. em Falco sparverius (Falconiformes, Falconidae; Colpocephalum sp. e Goniocotes parviceps em Pavo cristatus (Galliformes, Phasianidae; Goniodes pavonis em Rhea americana (Rheiformes, Rheidae; Colpocephalum cristatae e Heptapsogaster sp. em Cariama cristata (Gruiformes, Cariamidae; Austrophilopterus cancellosus em Ramphastos dicolorus (Piciformes, Ramphastidae; Strigiphilus crucigerus em Otus choliba (Strigiformes, Strigidae; Kurodaia sp. em Rhinoptynx clamator (Strigiformes, Strigidae e Colpocephalum pectinatum em Speotyto cunicularia (Strigiformes, Strigidae. As relações parasito hospedeiros em Strigiformes são novas no Brasil.Twelve chewing lice species were identified in Parque Zoológico Municipal Quinzinho de Barros, Sorocaba and Fundação Jardim Zoológico, Rio de Janeiro. The parasites found were: Ciconiphilus pectiniventris in Cygnus atratus (Anseriformes, Anatidae; Kurodaia sp. in Buteo albicaudatus (Falconiformes, Accipitridae; Degeeriella sp. in Falco sparverius (Falconiformes, Falconidae; Colpocephalum sp. and Goniocotes parviceps in Pavo cristatus (Galliformes, Phasianidae; Goniodes pavonis in Rhea americana (Rheiformes, Rheidae; Colpocephalum cristatae and Heptapsogaster sp. in Cariama cristata (Gruiformes, Cariamidae; Austrophilopterus cancellosus in Ramphastos dicolorus (Piciformes, Ramphastidae; Strigiphilus crucigerus in Otus choliba (Strigiformes, Strigidae; Kurodaia sp. in Rhinoptynx clamator (Strigiformes, Strigidae and Colpocephalum pectinatum in Speotyto cunicularia (Strigiformes, Strigidae. The host-lice relationships are new in Strigiformes in Brazil.

  11. Avaliação da eficácia do artesunato associado à tetraciclina na terapêutica da malária falciparum

    Directory of Open Access Journals (Sweden)

    Villalobos Salcedo Juan Miguel

    1997-01-01

    Full Text Available Realizou-se um ensaio clínico, randomizado e controlado, comparando o artesunato com o quinino e a mefloquina, em casos de malária não grave. Foram tratados 42 pacientes em regime de internação e o seguimento durou 28 dias. Realizou-se exame de gota espessa cada 12 horas até sua negativação, hemograma e bioquímica sanguínea, pré e pós-tratamento. A média da parasitemia inicial foi 42.568 parasitas/ml. Vinte e seis pacientes foram acompanhados durante 28 dias e 16 durante menos de 28 dias. Um paciente de cada grupo apresentou R I tardia e um paciente do grupo do quinino apresentou R III. As porcentagens de cura foram 88,8%, 85,7% e 81,8% para o artesunato, a mefloquina e o quinino, respectivamente, sem mostrar diferença significativa. O tempo de desaparecimento da febre não mostrou diferença significativa entre os grupos. O grupo do artesunato teve um tempo menor de clareamento da parasitemia (37,33 ± 11,52 horas quando comparado com o quinino (65,25 ± 17,44 horas, sendo estatisticamente significativa (p = 0,0016. O grupo da mefloquina (58,9 ± 16,68 horas não mostrou diferença com os outros grupos. Não se apresentaram efeitos adversos importantes em nenhum dos esquemas usados, sendo bem tolerados pelos pacientes.

  12. Reorganization of the actin cytoskeleton via transcriptional regulation of cytoskeletal/focal adhesion genes by myocardin-related transcription factors (MRTFs/MAL/MKLs)

    International Nuclear Information System (INIS)

    Morita, Tsuyoshi; Mayanagi, Taira; Sobue, Kenji

    2007-01-01

    RhoA is a crucial regulator of stress fiber and focal adhesion formation through the activation of actin nucleation and polymerization. It also regulates the nuclear translocation of myocardin-related transcription factor-A and -B (MRTF-A/B, MAL or MKL 1/2), which are co-activators of serum response factor (SRF). In dominant-negative MRTF-A (DN-MRTF-A)-expressing NIH 3T3 cell lines, the expressions of several cytoskeletal/focal adhesion genes were down-regulated, and the formation of stress fiber and focal adhesion was severely diminished. MRTF-A/B-knockdown cells also exhibited such cytoskeletal defects. In reporter assays, both RhoA and MRTF-A enhanced promoter activities of these genes in a CArG-box-dependent manner, and DN-MRTF-A inhibited the RhoA-mediated activation of these promoters. In dominant-negative RhoA (RhoA-N19)-expressing NIH 3T3 cell lines, the nuclear translocation of MRTF-A/B was predominantly prevented, resulting in the reduced expression of cytoskeletal/focal adhesion proteins. Further, constitutive-active MRTF-A/B increased the expression of endogenous cytoskeletal/focal adhesion proteins, and thereby rescued the defective phenotype of stress fibers and focal adhesions in RhoA-N19 expressing cells. These results indicate that MRTF-A/B act as pivotal mediators of stress fiber and focal adhesion formation via the transcriptional regulation of a subset of cytoskeletal/focal adhesion genes

  13. Epidemiology and Impact of Campylobacter Infection in Children in 8 Low-Resource Settings: Results From the MAL-ED Study.

    Science.gov (United States)

    Amour, Caroline; Gratz, Jean; Mduma, Estomih; Svensen, Erling; Rogawski, Elizabeth T; McGrath, Monica; Seidman, Jessica C; McCormick, Benjamin J J; Shrestha, Sanjaya; Samie, Amidou; Mahfuz, Mustafa; Qureshi, Shahida; Hotwani, Aneeta; Babji, Sudhir; Trigoso, Dixner Rengifo; Lima, Aldo A M; Bodhidatta, Ladaporn; Bessong, Pascal; Ahmed, Tahmeed; Shakoor, Sadia; Kang, Gagandeep; Kosek, Margaret; Guerrant, Richard L; Lang, Dennis; Gottlieb, Michael; Houpt, Eric R; Platts-Mills, James A

    2016-11-01

     Enteropathogen infections have been associated with enteric dysfunction and impaired growth in children in low-resource settings. In a multisite birth cohort study (MAL-ED), we describe the epidemiology and impact of Campylobacter infection in the first 2 years of life.  Children were actively followed up until 24 months of age. Diarrheal and nondiarrheal stool samples were collected and tested by enzyme immunoassay for Campylobacter Stool and blood samples were assayed for markers of intestinal permeability and inflammation.  A total of 1892 children had 7601 diarrheal and 26 267 nondiarrheal stool samples tested for Campylobacter We describe a high prevalence of infection, with most children (n = 1606; 84.9%) having a Campylobacter-positive stool sample by 1 year of age. Factors associated with a reduced risk of Campylobacter detection included exclusive breastfeeding (risk ratio, 0.57; 95% confidence interval, .47-.67), treatment of drinking water (0.76; 0.70-0.83), access to an improved latrine (0.89; 0.82-0.97), and recent macrolide antibiotic use (0.68; 0.63-0.74). A high Campylobacter burden was associated with a lower length-for-age Z score at 24 months (-1.82; 95% confidence interval, -1.94 to -1.70) compared with a low burden (-1.49; -1.60 to -1.38). This association was robust to confounders and consistent across sites. Campylobacter infection was also associated with increased intestinal permeability and intestinal and systemic inflammation.  Campylobacter was prevalent across diverse settings and associated with growth shortfalls. Promotion of exclusive breastfeeding, drinking water treatment, improved latrines, and targeted antibiotic treatment may reduce the burden of Campylobacter infection and improve growth in children in these settings. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.

  14. Dynamics and Trends in Fecal Biomarkers of Gut Function in Children from 1-24 Months in the MAL-ED Study.

    Science.gov (United States)

    McCormick, Benjamin J J; Lee, Gwenyth O; Seidman, Jessica C; Haque, Rashidul; Mondal, Dinesh; Quetz, Josiane; Lima, Aldo A M; Babji, Sudhir; Kang, Gagandeep; Shrestha, Sanjaya K; Mason, Carl J; Qureshi, Shahida; Bhutta, Zulfiqar A; Olortegui, Maribel Paredes; Yori, Pablo Peñataro; Samie, Amidou; Bessong, Pascal; Amour, Caroline; Mduma, Estomih; Patil, Crystal L; Guerrant, Richard L; Lang, Dennis R; Gottlieb, Michael; Caulfield, Laura E; Kosek, Margaret N

    2017-02-08

    Growth and development shortfalls that are disproportionately prevalent in children living in poor environmental conditions are postulated to result, at least in part, from abnormal gut function. Using data from The Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) longitudinal cohort study, we examine biomarkers of gut inflammation and permeability in relation to environmental exposures and feeding practices. Trends in the concentrations of three biomarkers, myeloperoxidase (MPO), neopterin (NEO), and α-1-antitrypsin (AAT), are described from fecal samples collected during the first 2 years of each child's life. A total of 22,846 stool samples were processed during the longitudinal sampling of 2,076 children 0-24 months of age. Linear mixed models were constructed to examine the relationship between biomarker concentrations and recent food intake, symptoms of illness, concurrent enteropathogen infection, and socioeconomic status. Average concentrations of MPO, NEO, and AAT were considerably higher than published references for healthy adults. The concentration of each biomarker tended to decrease over the first 2 years of life and was highly variable between samples from each individual child. Both MPO and AAT were significantly elevated by recent breast milk intake. All three biomarkers were associated with pathogen presence, although the strength and direction varied by pathogen. The interpretation of biomarker concentrations is subject to the context of their collection. Herein, we identify that common factors (age, breast milk, and enteric infection) influence the concentration of these biomarkers. Within the context of low- and middle-income communities, we observe concentrations that indicate gut abnormalities, but more appropriate reference standards are needed. © The American Society of Tropical Medicine and Hygiene.

  15. Hydrogenation-disproportionation-desorption-recombination in Sm2Fe16M (M=Al, Ga and Si) and magnetic properties of their carburized powders

    International Nuclear Information System (INIS)

    Kubis, M.; Rave, W.; Cao, L.; Gebel, B.; Mueller, K.-H.; Schultz, L.

    1998-01-01

    The application of the hydrogenation-disproportionation-desorption-recombination (HDDR) process in Sm 2 Fe 16 M (M=Al,Ga and Si) was investigated. The hydrogen absorption behaviour was studied by temperature-pressure analysis (TPA). In the temperature range between 500 and 800 C, Sm 2 Fe 16 M samples with M=Ga and Si show a weaker hydrogen absorption than Sm 2 Fe 16 Al. This was confirmed by X-ray diffraction which showed a complete disproportionation of Sm 2 Fe 16 Al into SmH z (1.9 2 Fe 16 Ga and Sm 2 Fe 16 Si exhibit a fraction of undecomposed material with the Th 2 Zn 17 -type structure after the disproportionation procedure. These results point to a stabilization of Sm 2 Fe 16 M against disproportionation by hydrogen for M=Ga and Si. The magnetization processes of carburized HDDR powders were studied by VSM measurements and Kerr microscopy. The demagnetization curve of our HDDR processed Sm 2 Fe 16 AlC y is well shaped, whereas those of Sm 2 Fe 16 GaC y and Sm 2 Fe 16 SiC y show a large decrease of the polarization at low fields. The favourable behaviour of Sm 2 Fe 16 AlC y is due to a homogeneous submicron grain structure. In Sm 2 Fe 16 GaC y and Sm 2 Fe 16 SiC y samples, an additional, magnetically soft phase with larger domains was observed which causes the low coercivity. As a consequence, HDDR was only favourable for the preparation of Sm 2 Fe 16 MC y hard magnets with M=Al but not for M=Ga and Si. Optimization of the HDDR process in Sm 2 Fe 16 Al and subsequent nitrogenation or carburization led to coercivities of μ 0j H c =2.9 and 2.5 T, respectively. (orig.)

  16. Rationale and design of the PREDICE project: cost-effectiveness of type 2 diabetes prevention among high-risk Spanish individuals following lifestyle intervention in real-life primary care setting.

    Science.gov (United States)

    Costa, Bernardo; Cabré, Joan J; Sagarra, Ramon; Solà-Morales, Oriol; Barrio, Francisco; Piñol, Josep L; Cos, Xavier; Bolíbar, Bonaventura; Castell, Conxa; Kissimova-Skarbek, Katarzyna; Tuomilehto, Jaakko

    2011-08-04

    can be obtained at a reasonable cost-effectiveness ratio in real-life primary health care setting by an intensive lifestyle intervention. As far as we know, the DE-PLAN-CAT/PREDICE project represents the first assessment of long-term effectiveness and cost-effectiveness of a public healthcare strategy to prevent diabetes within a European primary care setting.

  17. Evaluation of an anti-p185{sup HER2} (scFv-C{sub H}2-C{sub H}3){sub 2} fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK

    Energy Technology Data Exchange (ETDEWEB)

    Vaidyanathan, Ganesan [Duke University Medical Center, Durham, NC 27710 (United States)], E-mail: ganesan.v@duke.edu; Jestin, Emmanuelle [Duke University Medical Center, Durham, NC 27710 (United States); Olafsen, Tove; Wu, Anna M. [Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095 (United States); Zalutsky, Michael R. [Duke University Medical Center, Durham, NC 27710 (United States)

    2009-08-15

    Introduction: A 105-kDa double mutant single-chain Fv-Fc fragment (scFv-Fc DM) derived from the anti-p185{sup HER2} hu4D5v8 antibody (trastuzumab; Herceptin) has been described recently. The goal of this study was to investigate whether improved tumor targeting could be achieved with this fragment through the use of residualizing radioiodination methods. Methods: The scFv-Fc DM fragment was radioiodinated using N-succinimidyl 4-guanidinomethyl 3-[{sup 131}I]iodobenzoate ([{sup 131}I]SGMIB) and N{sup {epsilon}}-(3-[{sup 131}I]iodobenzoyl)-Lys{sup 5}-N{sup {alpha}}- maleimido-Gly{sup 1}-GEEEK ([{sup 131}I]IB-Mal-D-GEEEK), two residualizing radioiodination agents that have been used successfully with intact antibodies. Paired-label internalization assays of the labeled fragments were performed in vitro using MCF7 human breast cancer cells transfected to express HER2 (MCF7-HER2); comparisons were made to scFv-Fc DM directly radioiodinated using Iodogen. The tissue distribution of the scFv-Fc DM labeled with [{sup 125}I]IB-Mal-D-GEEEK and [{sup 131}I]SGMIB was compared in athymic mice bearing MCF7-HER2 xenografts. Results: The scFv-Fc DM fragment was labeled with [{sup 131}I]SGMIB and [{sup 131}I]IB-Mal-D-GEEEK in conjugation yields of 53% and 25%, respectively, with preservation of immunoreactivity for HER2. Internalization assays indicated that labeling via SGMIB resulted in a 1.6- to 3.5-fold higher (P<.05) retention of radioactivity, compared to that from the directly labeled fragment, in HER2-expressing cells during a 24-h observation period. Likewise, the amount of radioactivity retained in cells from the IB-Mal-D-GEEEK-labeled fragment was 1.4- to 3.3-fold higher (P<.05). Tumor uptake of radioiodine activity in athymic mice bearing MCF7-HER2 xenografts in vivo was significantly higher for the [{sup 125}I]IB-Mal-D-GEEEK-labeled scFv-Fc DM fragment compared with that of the [{sup 131}I]SGMIB-labeled fragment, particularly at later time points. The uptake of {sup

  18. Malaria diagnosis and treatment under the strategy of the integrated management of childhood illness (IMCI): relevance of laboratory support from the rapid immunochromatographic tests of ICT Malaria P.f/P.v and OptiMal.

    Science.gov (United States)

    Tarimo, D S; Minjas, J N; Bygbjerg, I C

    2001-07-01

    The algorithm developed for the integrated management of childhood illness (IMCI) provides guidelines for the treatment of paediatric malaria. In areas where malaria is endemic, for example, the IMCI strategy may indicate that children who present with fever, a recent history of fever and/or pallor should receive antimalarial chemotherapy. In many holo-endemic areas, it is unclear whether laboratory tests to confirm that such signs are the result of malaria would be very relevant or useful. Children from a holo-endemic region of Tanzania were therefore checked for malarial parasites by microscopy and by using two rapid immunochromatographic tests (RIT) for the diagnosis of malaria (ICT Malaria P.f/P.v and OptiMal. At the time they were tested, each of these children had been targeted for antimalarial treatment (following the IMCI strategy) because of fever and/or pallor. Only 70% of the 395 children classified to receive antimalarial drugs by the IMCI algorithm had malarial parasitaemias (68.4% had Plasmodium falciparum trophozoites, 1.3% only P. falciparum gametocytes, 0.3% P. ovale and 0.3% P. malariae). As indicators of P. falciparum trophozoites in the peripheral blood, fever had a sensitivity of 93.0% and a specificity of 15.5% whereas pallor had a sensitivity of 72.2% and a specificity of 50.8%. The RIT both had very high corresponding sensitivities (of 100.0% for the ICT and 94.0% for OptiMal) but the specificity of the ICT (74.0%) was significantly lower than that for OptiMal (100.0%). Fever and pallor were significantly associated with the P. falciparum asexual parasitaemias that equalled or exceeded the threshold intensity (2000/microl) that has the optimum sensitivity and specificity for the definition of a malarial episode. Diagnostic likelihood ratios (DLR) showed that a positive result in the OptiMal test (DLR = infinity) was a better indication of malaria than a positive result in the ICT (DLR = 3.85). In fact, OptiMal had diagnostic reliability (0

  19. Unravelling Local Atomic Order of the Anionic Sublattice in M(Al1-x Gax )4 with M=Sr and Ba by Using NMR Spectroscopy and Quantum Mechanical Modelling.

    Science.gov (United States)

    Pecher, Oliver; Mausolf, Bernhard; Peters, Volker; Lamberts, Kevin; Korthaus, Alexander; Haarmann, Frank

    2016-12-05

    The quasibinary section of the intermetallic phases MAl 4 and MGa 4 with M=Sr and Ba have been characterised by means of X-ray diffraction (XRD) studies and differential thermal analysis. The binary phases show complete miscibility and form solid solutions M(Al 1-x Ga x ) 4 with M=Sr and Ba. These structures crystallise in the BaAl 4 structure type with four- and five-bonded Al and/or Ga atoms (denoted as Al(4b), Al(5b), Ga(4b), and Ga(5b), respectively) that form a polyanionic Al/Ga sublattice. Solid state 27 Al NMR spectroscopic analysis and quantum mechanical (QM) calculations were applied to study the bonding of the Al centres and the influence of Al/Ga substitution, especially in the regimes with low degrees of substitution. M(Al 1-x Ga x ) 4 with M=Sr and Ba and 0.925≤x≤0.975 can be described as a matrix of the binary majority compound in which a low amount of the Ga atoms has been substituted by Al atoms. In good agreement with the QM calculations, 27 Al NMR investigations and single crystal XRD studies prove a preferred occupancy of Al(4b) for these substitution regimes. Furthermore, two different local Al environments were found, namely isolated Al(4b1) atoms and Al(4b2), due to the formation of Al(4b)-Al(4b) pairs besides isolated Al(4b) atoms within the polyanionic sublattice. QM calculations of the electric field gradient (EFG) using superlattice structures under periodic boundary conditions are in good agreement with the NMR spectroscopic results. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. O mal-estar na modernidade e a psicanálise: a psicanálise à prova do social The discontent in modernity and psychoanalysis: social-proof psychoanalysis

    Directory of Open Access Journals (Sweden)

    Joel Birman

    2005-01-01

    Full Text Available O artigo tem a intenção de indicar a presença de dois discursos teóricos opostos em Freud, no que concerne às relações entre sujeito e modernidade. Pretende-se demonstrar que na sua segunda versão, desenvolvida em Mal-estar na civilização, o discurso psicanalítico realizou uma crítica sistemática de sua versão inicial, esboçada em "Moral sexual 'civilizada' e a doença nervosa dos tempos modernos". Pela construção dos conceitos de desamparo e de mal-estar, o discurso freudiano colocou então a psicanálise à prova do social. Além disso, indica que aquela pôde construir uma leitura sobre a modernidade, ao lado das que foram realizadas por Weber e Heidegger. Finalmente, esse percurso tem ainda a finalidade de pensar a crise da psicanálise na atualidade, nas novas condições do mal-estar na modernidade.The article aims at showing the presence of two opposing theoretical discourses in Freud, in what concerns the relationship between the subject and modemity. It intends to demonstrate that in its second version, developed in Malaise dansia civilisation, the analytical discourse achieved a systematic critical review of its initial version outlined in "La morale sexuelle 'civilisée' et la maladie nerveuse des temps modemes". Through constructing the concepts of discontent and distress, the Freudian discourse thus made psychoanalysis social-proof. ln addition, it indicates that psychoanalysis was able to build a reading of modemity other than those made by Weber and Heidegger. Finally, this joumey also aims at thinking over the present crisis of psychoanalysis within the new conditions of discontent in modemity.

  1. “El florecimiento del terrorismo islámico en el Sahel, un reto para la seguridad de Europa Occidental. Estudio de caso: Malí y España (2011- 2013)”

    OpenAIRE

    Rodríguez Uribe, Mónica Alejandra

    2015-01-01

    El objetivo central de este Estudio de Caso, consiste en investigar en qué sentido la proximidad geográfica y el hecho de que la región del Sahel constituya una zona de tránsito, influyen a que el crecimiento del terrorismo islámico en Malí comprenda una amenaza tanto para la seguridad nacional, como para la estabilidad de España. Se avanzará posteriormente con la descripción de herramientas específicas, tanto judiciales como de cooperación que el gobierno español ha buscado apoyar a nivel ...

  2. Luminescent phosphors, based on rare earth substituted oxyfluorides in the A(1)3-x A(2)xMO4F family with A(1)/A(2)=Sr, Ca, Ba and M=Al, Ga

    International Nuclear Information System (INIS)

    Park, Sangmoon; Vogt, Thomas

    2009-01-01

    A new family of UV-activated phosphors made by substituting rare-earth activators such as trivalent Eu, Tb, Tm and Er into A(1) 3-x A(2) x MO 4 F host lattices (A(1)/A(2)=Sr, Ca, Ba; M=Al, Ga) are introduced and their activation and emission spectra as well as their CIE values reported. The Tm-substituted system can be activated using light with a wavelength of 360 nm. Relative intensities of a family of Tb-substituted green phosphors activated at 254 nm and with emissions centered near 548 nm are discussed.

  3. Luminescent phosphors, based on rare earth substituted oxyfluorides in the A(1){sub 3-x} A(2){sub x}MO{sub 4}F family with A(1)/A(2)=Sr, Ca, Ba and M=Al, Ga

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sangmoon, E-mail: spark@silla.ac.k [Department of Engineering in Energy and Applied Chemistry, Silla University, Busan 617-736 (Korea, Republic of); Vogt, Thomas [NanoCenter and Department of Chemistry and Biochemistry, University of South Carolina, Columbia 29208, SC (United States)

    2009-09-15

    A new family of UV-activated phosphors made by substituting rare-earth activators such as trivalent Eu, Tb, Tm and Er into A(1){sub 3-x}A(2){sub x}MO{sub 4}F host lattices (A(1)/A(2)=Sr, Ca, Ba; M=Al, Ga) are introduced and their activation and emission spectra as well as their CIE values reported. The Tm-substituted system can be activated using light with a wavelength of 360 nm. Relative intensities of a family of Tb-substituted green phosphors activated at 254 nm and with emissions centered near 548 nm are discussed.

  4. Estudio descriptivo de mal oclusiones y opciones de tratamiento en estudiantes de segundo y tercer semestre de la Universidad de las Américas del Distrito Metropolitano de Quito, período Octubre 2013 – Enero 2014

    OpenAIRE

    Santacruz Escobar, Paul Santiago

    2014-01-01

    Las mal oclusiones dentales son patologías frecuentes en la cavidad bucal a nivel mundial, debido a que esta enfermedad es multifactorial además de verse afectada por otros procesos patológicos, surge la importancia decisiva de tomar medidas de salud pública para contrarrestar las secuelas de dicha enfermedad, así como su pronta prevención. El presente estudio es de carácter descriptivo, transversal, en el cual fueron examinados 268 estudiantes entre diecisiete y veinte y cinco años de edad, ...

  5. La miseria de la literatura: el mal en las representaciones de los escritores de La literatura nazi en América, Estrella distante y la no ficción de Roberto Bolaño

    OpenAIRE

    Villacreses Benavides, Norman Xavier

    2016-01-01

    La obra y la figura como escritor de Roberto Bolaño es uno de los espacios de investigación de los estudios literarios más importantes en la actualidad. Esto se debe tanto a la repercusión de su ficción dentro de la narrativa hispanoamericana contemporánea como a sus posiciones frente al ejercicio de la literatura. Esta investigación se ha propuesto hallar de qué forma se generan las representaciones del mal dentro del universo literario de Bolaño y cuál es su funcionamiento, tomando como ele...

  6. Un cinéma palestinien « en mal d’archive » The “Archive Fever” of Palestinian Cinema

    Directory of Open Access Journals (Sweden)

    Laure Fourest

    2012-05-01

    Full Text Available À partir de l’analyse de trois films palestiniens réalisés dans les années 2000, cet article propose d’interroger l’insertion d’images d’archives par les cinéastes dans leur montage : quelles stratégies mettent-ils en œuvre et à quelles fins ? Qu’apportent des images d’archives en plus des témoignages filmés ? Comment le recours à ces images permet-il de participer au débat historiographique qui sous-tend et détermine en partie le conflit israélo-palestinien ? Dans le contexte palestinien où il n’existe pas d’institution archivistique officielle, les archives sont porteuses d’enjeux particulièrement saillants, donnant lieu à un véritable « mal d’archive ». Celui-ci fait naître une multiplicité de stratégies cinématographiques visant à questionner cette zone d’inconfort, où le maniement des qualités émotionnelles et sensorielles de l’archive peut être un moyen de faire preuve.Through the analysis of three Palestinian films created in the 2000-2010 period, this article considers filmmakers’ insertion of archival images in their montages: what strategies do they employ and for what purpose? What do archival images add to filmed testimony? How does the use of these images enable participation in the historiographical debate underlying and partly determining the Israel-Palestine conflict? In the Palestinian context, where no official archive institution exists, archives entail particularly salient issues, making their lack truly sore. This generates a multiplicity of cinematographic strategies aiming to challenge this discomfort zone, where the manipulation of the emotional and sensorial qualities of archives can be a means of proving something.

  7. Hydrogenation-disproportionation-desorption-recombination in Sm{sub 2}Fe{sub 16}M (M=Al, Ga and Si) and magnetic properties of their carburized powders

    Energy Technology Data Exchange (ETDEWEB)

    Kubis, M.; Rave, W.; Cao, L.; Gebel, B.; Mueller, K.-H.; Schultz, L. [Institut fuer Festkoerper- und Werkstofforschung Dresden e.V. (Germany)

    1998-11-20

    The application of the hydrogenation-disproportionation-desorption-recombination (HDDR) process in Sm{sub 2}Fe{sub 16}M (M=Al,Ga and Si) was investigated. The hydrogen absorption behaviour was studied by temperature-pressure analysis (TPA). In the temperature range between 500 and 800 C, Sm{sub 2}Fe{sub 16}M samples with M=Ga and Si show a weaker hydrogen absorption than Sm{sub 2}Fe{sub 16}Al. This was confirmed by X-ray diffraction which showed a complete disproportionation of Sm{sub 2}Fe{sub 16}Al into SmH{sub z} (1.9M=Al but not for M=Ga and Si. Optimization of the HDDR process in Sm{sub 2}Fe{sub 16}Al and subsequent nitrogenation or carburization led to coercivities of {mu}{sub 0j}H{sub c}=2.9 and 2.5 T, respectively. (orig.) 11 refs.

  8. Faktoring – jedna z hlavních forem financování malých a středních podniků

    Directory of Open Access Journals (Sweden)

    Müllerová Libuše

    2009-12-01

    Full Text Available Faktoring představuje službu, kterou poskytují specializované faktoringové společnosti svým klientům v souvislosti s postoupením nebo se správou pohledávek. Ve své podstatě se jedná o určitý způsob úvěrování, využívaný zejména malými a středními podniky. V praxi existuje několik forem faktoringu v závislosti na tom, do jaké míry přechází na faktora vlastnictví pohledávek a rizika jejich nesplacení. Podle toho se pak faktoringové transakce promítají do účetnictví faktora i klienta. Vzhledem k tomu, že tato služba ani její formy není upravená žádným právním předpisem, postupují faktoringové společnosti často tak, že podmínky ve smlouvách – z důvodu daňových – často zakrývají svojí formou skutečný stav. Uvedený příspěvek základní formy faktoringu vymezuje, popisuje jejich správné účtování včetně daňových dopadů. Factoring is a service, which is offered by specialized factoring agencies to their clients in case of transfer (sale or governance of receivables. In fact, it represents a specific mode of crediting which is mostly preferred by small and medium enterprises. In practices of factoring several forms are differentiated depending on scale of property and risk transfer to the factor. According to these circumstances the factoring transactions are recognized by the factor and the client. The factoring services are not so far regulated by any legal provision. For this reason factoring agencies are proceeding in such a way, that contract conditions – because of tax considerations – hide by their form the substance. The paper describes the factoring forms and interprets their correct recognition on accounting, including tax consequences.

  9. FACTORES ASOCIADOS A MAL ESTADO DE SALUD PERCIBIDO O A MALA CALIDAD DE VIDA EN PERSONAS MAYORES DE 65 AÑOS

    Directory of Open Access Journals (Sweden)

    Mercedes Azpiazu Garrido

    2002-01-01

    Full Text Available Fundamento: Hoy en d a, en los pa ses desarrollados, llegar a una edad avanzada ha dejado de ser algo excepcional, sin embargo muchas personas no logran envejecer con una buena calidad de vida. El presente trabajo tiene como objetivos, contribuir a un mejor conocimiento de los principales factores que influyen en la calidad de vida y la percepci n de la salud de los mayores de 65 a os, as como determinar qu ventajas y desventajas presenta cada uno de los tres instrumentos de medida de la salud y la calidad de vida frente a los otros dos instrumentos utilizados. M todos: A partir de 911 encuestas a personas mayores de 65 a os no institucionalizadas, realizadas a domicilio, se hizo un an lisis multivariante mediante regresi n log stica, poniendo en relaci n los resultados obtenidos en el Perfil de Salud de Nottingham (PSN, el Euroqol y el EAS con las caracter siticas sociodemogr ficas, el nivel de recursos econ micos, el grado de apoyo sociofamiliar, el estado de salud f sica y mental y la capacidad funcional. Resultados: Los principales factores que se asocian con la percepci n de un mal estado de salud y mala calidad de vida en el Euroqol y el PSN son los trastornos de ansiedad (Odd Ratios entre 1,8 (IC:1,2-2,8 para movilidad y 7,9 (IC:4,5-13,9 para Perfil 11111, trastornos depresivos (OR:1,8 (IC:1,3-2,6 para dolor/malestar ?3,3 (IC:2,1-5,1 para aislamiento social, falta de ejercicio (OR:1,4 (IC:1-2,1 para ansiedad/depresi n ?3,9 (IC:2,5-6,2 para actividades cotidianas, dependencia para las actividades b sicas de la vida diaria (OR:0,5 (IC:0,3-0,9 para reacci n emocional ?4,8 (IC:3-7,6 para actividades cotidianas y dependencia para las actividades instrumentales de la vida diaria (OR:1,5 (IC:1,1-2,1 para Escala Visual Anal gicac < 70 ? 7,1 (IC:2,9-17,2 para cuidado personal. Conclusiones: La salud mental y la capacidad funcional son los factores que m s influyen en la percepci n del estado de salud y la calidad de vida de las personas mayores

  10. Retardo no crescimento intrauterino, baixo peso ao nascer e prematuridade em recém-nascidos de grávidas com malária, na Colômbia Intrauterine growth retardation, low birth weight and prematurity in neonates of pregnant women with malaria in Colombia

    OpenAIRE

    Alberto Tobón-Castaño; Martha Arismendi Solano; Luis Gonzalo Álvarez Sánchez; Silvia Blair Trujillo

    2011-01-01

    INTRODUÇÃO: É frequente a associação da malária com complicações como prematuridade, retardo no crescimento intrauterino, baixo peso ao nascer e mortalidade infantil, efeitos pouco estudados em áreas hipoendêmicas para malaria. O objetivo deste estudo foi analisar a relação da malária gestacional com estes efeitos em recém-nascidosnuma região endêmica para malária na Colômbia, entre 1993 e 2007. MÉTODOS: Foram estudadas as características em 1.716 recém-nascidos num estudo de coorte. Fez-se s...

  11. Malária durante a gravidez: efeito sobre o curso da gestação na região amazônica Impact of malaria during pregnancy in the Amazon region

    Directory of Open Access Journals (Sweden)

    Eda Cristina da Silva Chagas

    2009-09-01

    Full Text Available OBJETIVO: Estimar o efeito da malária sobre o curso da gestação em mulheres na região amazônica e investigar possíveis fatores de risco nessa população. MÉTODOS: Este estudo transversal é parte de um projeto maior para estudar malária e gravidez na região amazônica. Foram incluídas gestantes com malária atendidas na Fundação de Medicina Tropical do Amazonas que responderam a entrevistas estruturadas. Dados socio-econômicos, comportamentais e clínicos foram levantados na primeira consulta relacionada a cada novo episódio de malária na gestante. Todas as gestantes foram acompanhadas ao longo de sua gestação. Foram considerados os seguintes fatores de risco para alterações no curso da gestação: idade materna menor do que 20 anos, primeira gestação, primeira infecção malárica e espécie de plasmódio infectante. RESULTADOS: Foram avaliados 535 episódios de malária em 417 gestantes, sendo 20,56% causados pelo P. falciparum, 78,69% pelo P. vivax e 0,75% pela associação dos dois parasitas. Alteração no curso da gestação foi um evento muito frequente (26,2%. Ameaça de aborto ocorreu em 49 casos (25,5%, aborto em dois (1,0%, ameaça de parto prematuro em 74 (25,1% e parto prematuro em três (1,0%. Ser primigesta e adolescente apresentou associação estatisticamente significativa com ameaça de parto prematuro e abortamento. CONCLUSÃO: A alteração no curso da gestação foi um evento muito frequente durante o episódio agudo de malária, embora a interrupção da gestação tenha tido baixa ocorrência em nossa casuística. Os resultados não evidenciaram um fator de risco de destaque, sugerindo que qualquer gestante pode apresentar ameaça de interrupção ou interrupção da gestação na vigência de episódio agudo de malária.OBJECTIVE: To estimate the impact of malaria on the course of pregnancy in women from the Amazon region and to investigate possible risk factors in this population. METHODS: This

  12. Structure, microstructure and determination of optical constants from transmittance data of co-doped Zn0.90Co0.05M0.05O (M=Al, Cu, Cd, Na) films

    International Nuclear Information System (INIS)

    2 A Laboratoire des Structures, Propriétés et Interactions Inter Atomiques, Université Abbes Laghrour, Khenchela 40000 (Algeria))" data-affiliation=" (LASPI2 A Laboratoire des Structures, Propriétés et Interactions Inter Atomiques, Université Abbes Laghrour, Khenchela 40000 (Algeria))" >Roguai, S.; 2 A Laboratoire des Structures, Propriétés et Interactions Inter Atomiques, Université Abbes Laghrour, Khenchela 40000 (Algeria))" data-affiliation=" (LASPI2 A Laboratoire des Structures, Propriétés et Interactions Inter Atomiques, Université Abbes Laghrour, Khenchela 40000 (Algeria))" >Djelloul, A.; Nouveau, Corinne; Souier, T.; Dakhel, A.A.; Bououdina, M.

    2014-01-01

    Highlights: • A series of Zn 0.90 Co 0.05 M 0.05 O (M=Al, Cu, Cd, Na) films has been prepared. • Thin films of these prepared samples have been deposited using USP technique. • Absorption of electronic transition has been used to fit the transmittance data. • Optical and dispersion parameters have been determined. - Abstract: ZnO, Zn 0.95 Co 0.05 O and Zn 0.90 Co 0.05 M 0.05 O (M=Al, Cd, Na, Cu) single phase films have been successfully synthesized by ultrasonic spray pyrolysis technique. Structural analysis by X-ray diffraction show that all the films have hexagonal wurtzite structure with an average crystallite size in the range of 19–25 nm. SEM analysis revealed that Cd and Na preserve the shape of nanopetals observed with ZnO or Co-ZnO films, while the doping with Al or Cu promote the formation of dense films constituted of nanorods. By the application of Levenberg–Marquardt least square method, the experimental transmittance data were fitted perfectly with the transmittance data calculated via a combination of Wemple–DiDomenico model, absorption coefficient of an electronic transition and Tauc–Urbach model. The concentration of absorbing centres N Co and oscillator strength f of d–d transition of Co 2+ ions are calculated from Smakula’s formula

  13. Luminescent properties of MAl(SO4)2 Br:Eu(3+) (M = Sr or Mg) red phosphors for near-UV light-emitting diodes.

    Science.gov (United States)

    Deshmukh, Priti B; Puppalwar, S P; Dhoble, N S; Dhoble, S J

    2015-02-01

    Eu(3+) -activated MAl(SO4 )2 Br phosphors (where M = Mg or Sr) are successfully prepared using a wet chemical reaction technique. The samples are characterized by X-ray diffraction (XRD) and photoluminescence (PL) spectroscopies. The XRD pattern revealed that both the samples are microcrystalline in nature. PL of Eu(3+) -doped SrAl(SO4 )2 Br and MgAl(SO4 )2 Br phosphors exhibited characteristic red emission coming from the (5) D0  → (7) F2 (616 nm) electron transition, when excited by 396 nm wavelength of light. The maximum intensity of luminescence was observed at a concentration of 1 mol% Eu(3+) . The intensity of the electric dipole transition at 616 nm is greater than that of the magnetic dipole transition at 594 nm. The results showed that MAl(SO4 )2 Br:Eu(3+) , (M = Mg, Sr) phosphors have potential application in near-UV light-emitting diodes as efficient red-emitting phosphor. Copyright © 2014 John Wiley & Sons, Ltd.

  14. Prostorové rozhraní informačního systému malé obce řešené v Open Source Software

    Directory of Open Access Journals (Sweden)

    Karel Jedlička

    2006-12-01

    Full Text Available Příspěvek si klade za cíl představit možnosti open source software pro implementaci prostorového rozhraní informačního systému malé obce.Zabývá se návrhem projektu po jednotlivých částech: identifikace požadavků zastupitelského úřadu (uživatele systému, popis obecné architektury systému a volba vhodných (nekomerčních technologií pro jeho implementaci. Součástí projektu je i popis vyvinuté technologie pro import nejdůležitějších datových vrstev (informací o vlastnictví do systému.Článek je doplněn výčtem využitelných datových zdrojů pro informační systém malé obce v České republice.

  15. Fertilizantes e espaçamento entre plantas na produtividade da couve-da-Malásia Fertilizers and spacing between plants in the yield of Malaysian cabbage

    Directory of Open Access Journals (Sweden)

    Wanessa Resende Ferreira

    2002-12-01

    Full Text Available As brássicas têm sido objeto constante de pesquisa devido à sua importância na alimentação humana, seja pela quantidade consumida, pelo alto valor nutricional ou por sua elevada produtividade. Brassica chinensis var. parachinensis foi introduzida no Brasil, Uberlândia, em 1992, destacando-se em relação a outras brássicas por seu alto teor de vitaminas A e C, cálcio e ferro, estando pronta para consumo em aproximadamente 30 dias. A produtividade biológica e agronômica dessa variedade foi analisada utilizando-se três tipos de fertilizantes e três espaçamentos entre plantas, visando subsidiar sua produção em escala comercial. A área foliar, massa da matéria seca e taxa de crescimento absoluto foram significativamente maiores com adubação mineral em relação à adubação orgânica. Os maiores valores referentes à taxa de crescimento relativo e taxa assimilatória líquida foram registrados em plantas mantidas nos maiores espaçamentos (30x20 e 30x30 cm. A maior produtividade agronômica foi alcançada no menor espaçamento (30x10 cm, com adubação mineral, sendo registrados 21,5 t ha-1, valor muito próximo ao registrado na Malásia e China onde essa hortaliça é cultivada em larga escala.Brassica crops have been widely studied due to their importance as food for human consumption, especially in relation to their nutritional value. Both yield and consumption are high. Brassica chinensis var. parachinensis was introduced in Brazil, in Uberlândia, in 1992, surpassing other Brassica due to its high content of vitamins A and C, calcium and iron, and being ready for consumption in about 30 days. The biological and agronomic yield of this variety was analyzed under three kinds of fertilizers and three spacings between plants with a view to its production on a commercial scale. The leaf area, dry matter mass, and absolute growth rate were higher with mineral than organic fertilizer. High values for relative growth rate and net

  16. Ejercicio y la detección del mal agudo de montaña grave Exercise and the detection of severe acute mountain sickness

    Directory of Open Access Journals (Sweden)

    Adrián Garófoli

    2010-02-01

    Full Text Available El mal agudo de montaña (MAM es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2.700 m y 4 300 m en 63 sujetos que ascendían al cerro Aconcagua (6 962 m. Se consideró desaturación de oxígeno con ejercicio a una disminución = 5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. Seis sujetos presentaron MAM grave (9.5% y requirieron evacuación. La saturación de oxígeno en reposo a 2.700 m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2.700 m más la saturación inapropiada en reposo a 4.300 m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave.Acute mountain sickness (AMS is a group of non-specific symptoms, seen in subjects that ascend from low to high altitude too quickly, without allowing sufficient time to acclimatize. Usually it is self-limiting, but the severe forms (pulmonary and cerebral edema can be fatal. Exaggerated hypoxemia at rest is related to later development of AMS but its predictive value is limited. Since exercise at altitude induces greater hypoxemia and

  17. Factores asociados a mal estado de salud percibido o a mala calidad de vida en personas mayores de 65 años

    Directory of Open Access Journals (Sweden)

    Azpiazu Garrido Mercedes

    2002-01-01

    Full Text Available Fundamento: Hoy en día, en los países desarrollados, llegar a una edad avanzada ha dejado de ser algo excepcional, sin embargo muchas personas no logran envejecer con una buena calidad de vida. El presente trabajo tiene como objetivos, contribuir a un mejor conocimiento de los principales factores que influyen en la calidad de vida y la percepción de la salud de los mayores de 65 años, así como determinar qué ventajas y desventajas presenta cada uno de los tres instrumentos de medida de la salud y la calidad de vida frente a los otros dos instrumentos utilizados. Métodos: A partir de 911 encuestas a personas mayores de 65 años no institucionalizadas, realizadas a domicilio, se hizo un análisis multivariante mediante regresión logística, poniendo en relación los resultados obtenidos en el Perfil de Salud de Nottingham (PSN, el Euroqol y el EAS con las caracterísiticas sociodemográficas, el nivel de recursos económicos, el grado de apoyo sociofamiliar, el estado de salud física y mental y la capacidad funcional. Resultados: Los principales factores que se asocian con la percepción de un mal estado de salud y mala calidad de vida en el Euroqol y el PSN son los trastornos de ansiedad (Odd Ratios entre 1,8(IC:1,2-2,8 para movilidad y 7,9(IC:4,5-13,9 para Perfil ≠11111, trastornos depresivos (OR:1,8(IC:1,3-2,6 para dolor/malestar- 3,3(IC:2,1-5,1 para aislamiento social, falta de ejercicio (OR:1,4 (IC:1-2,1 para ansiedad/depresión -3,9(IC:2,5-6,2 para actividades cotidianas, dependencia para las actividades básicas de la vida diaria (OR:0,5(IC:0,3-0,9 para reacción emocional - 4,8(IC:3-7,6 para actividades cotidianas y dependencia para las actividades instrumentales de la vida diaria (OR:1,5(IC:1,1-2,1 para Escala Visual Analógicac<70 - 7,1(IC:2,9-17,2 para cuidado personal. Conclusiones: La salud mental y la capacidad funcional son los factores que más influyen en la percepción del estado de salud y la calidad de vida de las

  18. Necropsia e mortalidade por causa mal definida no Estado de São Paulo, Brasil Autopsy and ill-defined cause of death in the state of São Paulo, Brazil

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    Mauro Abrahão Rozman

    2006-11-01

    Full Text Available OBJETIVO: Investigar a proporção de mortes por causa mal definida no Estado de São Paulo entre 1980 e 2002, considerando a influência da realização de necropsia nessa proporção. MÉTODO: O número de óbitos foi obtido do Ministério da Saúde. Dividiu-se o Estado de São Paulo em três áreas: 1 municípios com serviço de verificação de óbitos (SVO, que pode realizar necropsias; 2 municípios sem SVO; e 3 Baixada Santista, região onde houve um aumento marcante na proporção de mortes por causa mal definida entre 1980 e 1995. O impacto das necropsias na proporção de óbitos por causa mal definida foi medido com base na classificação da causa de óbito pelo primeiro médico avaliador (aquele que encaminhou o caso para o SVO para necropsia ou que preencheu a declaração de óbito sem encaminhar o caso. Os óbitos por causas externas foram excluídos por ter necropsia obrigatória. Foram avaliadas as proporções 1 de casos classificados como de causa mal definida pelo primeiro avaliador; 2 de necropsias no total de óbitos excluindo causas externas; e 3 de óbitos com causa esclarecida por necropsia entre os classificados como de causa mal definida pelo primeiro avaliador. RESULTADOS: A proporção de óbitos classificados como de causa mal definida pelo primeiro avaliador aumentou entre 1980 e 2002 em todas as áreas: nos municípios com SVO, nos municípios sem SVO e na Baixada Santista. Para o Estado de São Paulo como um todo, o aumento foi de quase 30% no período de 1980 a 2002. Para o período de 1998 a 2002, a proporção média de necropsias no total de óbitos excluindo causas externas foi de 21,2, 6,4 e 2,6%, respectivamente, nas áreas com e sem SVO e na Baixada Santista. Entre 1998 e 2002, a proporção de óbitos com causa mal definida esclarecidos pela necropsia foi de 92,9 nas áreas com SVO, 32,5 nas áreas sem SVO e 10,7% na Baixada Santista. CONCLUSÕES: A realização de necropsias explica a diferença na

  19. Genesis of the Assif El Mal Zn-Pb (Cu, Ag) vein deposit. An extension-related Mesozoic vein system in the High Atlas of Morocco. Structural, mineralogical, and geochemical evidence

    Science.gov (United States)

    Bouabdellah, M.; Beaudoin, G.; Leach, D.L.; Grandia, F.; Cardellach, E.

    2009-01-01

    The Assif El Mal Zn-Pb (Cu-Ag) vein system, located in the northern flank of the High Atlas of Marrakech (Morocco), is hosted in a Cambro-Ordovician volcaniclastic and metasedimentary sequence composed of graywacke, siltstone, pelite, and shale interlayered with minor tuff and mudstone. Intrusion of synorogenic to postorogenic Late Hercynian peraluminous granitoids has contact metamorphosed the host rocks giving rise to a metamorphic assemblage of quartz, plagioclase, biotite, muscovite, chlorite, amphibole, chloritoid, and garnet. The Assif El Mal Zn-Pb (Cu-Ag) mineralization forms subvertical veins with ribbon, fault breccia, cockade, comb, and crack and seal textures. Two-phase liquid-vapor fluid inclusions that were trapped during several stages occur in quartz and sphalerite. Primary inclusion fluids exhibit Th mean values ranging from 104??C to 198??C. Final ice-melting temperatures range from -8.1??C to -12.8??C, corresponding to salinities of ???15 wt.% NaCl equiv. Halogen data suggest that the salinity of the ore fluids was largely due to evaporation of seawater. Late secondary fluid inclusions have either Ca-rich, saline (26 wt.% NaCl equiv.), or very dilute (3.5 wt.% NaCl equiv.) compositions and homogenization temperatures ranging from 75??C to 150??C. The ??18O and ??D fluid values suggest an isotopically heterogeneous fluid source involving mixing between connate seawater and black-shale-derived organic waters. Low ??13CVPDB values ranging from -7.5??? to -7.7??? indicate a homogeneous carbon source, possibly organic matter disseminated in black shale hosting the Zn-Pb (Cu-Ag) veins. The calculated ??34SH2S values for reduced sulfur (22.5??? to 24.3???) are most likely from reduction of SO42- in trapped seawater sulfate or evaporite in the host rocks. Reduction of sulfate probably occurred through thermochemical sulfate reduction in which organic matter was oxidized to produce CO2 which ultimately led to precipitation of saddle dolomite with

  20. Malária em grávidas de uma maternidade pública de Rio Branco (Acre, Brasil Malaria in pregnant women of a public maternity of Rio Branco (Acre State, Brazil

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    Regina Jarude

    2003-04-01

    Full Text Available OBJETIVO: descrever a freqüência dos achados clínico-laboratoriais em grávidas portadoras de malária. MÉTODOS: foi realizado estudo descritivo, série de casos, de 445 grávidas da Maternidade e Clínica de Mulheres Bárbara Heliodora (Rio Branco, Acre, do período de janeiro de 1996 a dezembro de 2001, com diagnóstico parasitológico de malária. Foram revistos os prontuários do período e selecionados os casos portadores de malária. RESULTADOS: no total de pacientes (n=33.420 internadas no período, estavam incluídas 445 (1,4% grávidas. Entre essas, a freqüência da infecção por Plasmodium vivax foi de 52,8% (n=235, por P. falciparum, de 43,8% (n=195, e 3,4% (n=15 por ambos os plasmódios. As alterações clínico-laboratoriais mais freqüentes (pPURPOSE: to describe the frequency of clinical and laboratorial findings in pregnant women with malaria. METHODS: a descriptive study was performed including 445 pregnant women with a positive diagnosis of malaria of the Maternity and women's Clinic Bárbara Heliodora (Rio Branco, Acre State, from January 1996 to December 2001. These cases were reviewed and the pregant women with malaria were selected. RESULTS: a total of 33,420 patients were hospitalized in that period. Of these, 445 pregnant women (1.4% were included. Among these, the frequency of the infection with Plasmodium vivax was 52.8% (n=235, with P. falciparum, 43.8% (n=195, and 3.4% (n=15 with both plasmodia. The most frequent clinical and laboratorial alterations (p<0.05 were observed in the patients with P. falciparum: pale mucosa, jaundice hemoglobin and hematocrit decrease, hypoglycemia and increase in serum aminotransferase, urea, creatinine and in bilirubin levels. Only one patient (1/445, a pregnant woman infected with P. falciparum died. Abortions, premature birth and low birth weight were detected in 1.3, 1.1 and 1.1% of the cases, respectively. CONCLUSIONS: these findings reflect the repercussion of malaria during

  1. Mercury exposure and malaria prevalence among gold miners in Pará, Brazil Exposição a mercúrio e prevalência de malária entre garimpeiros de ouro do Pará, Brasil

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    Ellen K. Silbergeld

    2002-10-01

    Full Text Available Economic development, including resource extraction, can cause toxic exposures that interact with endemic infectious diseases. Mercury is an immunotoxic metal used in the amalgamation of gold, resulting in both occupational exposures and environmental pollution. A cross-sectional medical survey was conducted in 1997 on 135 garimpeiros in Para, Brazil, because of their risks of both mercury exposure and malaria transmission. Mean levels of blood and urine mercury were well above non-exposed background levels. Twenty-six subjects had malaria parasitemia: Health symptoms consistent with mercury exposure were reported, but neither symptoms nor signs correlated with mercury levels in blood or urine. We did not find a dose response relationship between mercury exposure and likelihood of prevalent malaria infection, but there was a possible reduction in acquisition of immunity that may be associated with conditions in gold mining, including mercury exposure.O desenvolvimento econômico, incluindo extração de recursos naturais, pode causar exposições tóxicas que interagem com doenças infecciosas endêmicas. O mercúrio é um metal imunotóxico usado na amalgamação do ouro, resultando em exposição ocupacional e poluição ambiental. Devido aos riscos da exposição ao mercúrio e transmissão de malária em 135 garimpeiros do Pará, Brasil, uma avaliação médica "cross-sectional" foi coduzida em 1997. Níveis médios de mercúrio no sangue e na urina encontram-se bem acima dos níveis basais daqueles não expostos. Vinte e seis indivíduos apresentaram parasitemia de malária; sintomas relacionados com exposição ao mercúrio foram adquiridos, mas nenhum dos sintomas/sinais está correlacionado com níveis de mercúrio no sangue ou na urina. Não foi encontrada nenhuma relação de dose-resposta entre exposição ao mercúrio e provável infecção de malária prevalente. Entretanto, verificou-se uma possível redução na aquisição de

  2. O desafio da malária: o caso brasileiro e o que se pode esperar dos progressos da era genômica The malaria challenge: the Brazilian case and what can be expected from progress in genomics

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    Luiz Hildebrando Pereira da Silva

    2002-01-01

    Full Text Available A área endêmica de malária no Brasil se estende atualmente à totalidade da região amazônica, com cerca de 500 mil casos anuais, em geral com situações de baixa e média endemicidade mas ainda apresentando focos de alto risco. Fatores demográficos e socioeconômicos são dominantes nos desafios que enfrentam os Serviços de Saúde Pública no controle da malária. No presente artigo são discutidos fatores determinantes da instabilidade da situação endêmica bem como a necessidade de ações permanentes de vigilância e de intervenção dos Serviços de Saúde para que se evitem surtos epidêmicos e alastramento das áreas endêmicas. No artigo, em seguida, apresenta-se uma síntese de progressos recentes nos estudos da era genômica e pós-genômica sobre o parasita, o vetor e o hospedeiro humano que podem favorecer, no futuro, o desenvolvimento e a melhoria dos métodos de controle da malária.Malaria endemic areas in Brazil are restricted to the Amazon Region, with an average of 500 thousand new cases every year. The situation can be defined as unstable hipoendemic with, however, foci of high endemicity. Demographic and socio economic factors are main determinants in the malaria challenge for the Public Health System. In the present paper, biological and social factors responsible for the unstable endemic situation are discussed. The need for a permanent surveillance and intervention of Public Health Services are stressed to avoid the occurrence of local epidemics and spreading of endemic areas. In the paper, are also summarised recent lines of research developed in the post genomic era in the studies of parasite, vector and human molecular genetics that would favour the development, in the future, of new tools and procedures for malaria control

  3. Malária no Estado do Amapá, Brasil, de 1970 a 2003: trajetória e controle Malaria in Amapá State, Brazil, 1970-2003: background and control

    Directory of Open Access Journals (Sweden)

    Rosilene Ferreira Cardoso

    2007-06-01

    Full Text Available O presente estudo tem por objetivo dimensionar a ocorrência de malária no Estado do Amapá, Brasil, no período de 1970 a 2003. Com dados de lâminas positivas, obtidos junto a agências de informações em saúde, foi construída uma série temporal de índice parasitário anual (IPA, por mil habitantes, considerando as informações de população obtidas junto ao Instituto Brasileiro de Geografia e Estatística. No contexto de um intenso incremento populacional, associado ao desenvolvimento regional, os resultados evidenciaram um aumento no período - não linear - dos valores de IPA, que passaram de 15,1‰, em 1970, para 74‰ no ano 2000. No reverso desse movimento, em meio aos esforços de controle da doença, observa-se uma queda desses valores a partir de 2001, que alcança a ordem prevista de 50% em 2002. Acompanhando o movimento de incidência parasitária anual da malária na Amazônia, esses resultados apontaram para o aumento dos valores do IPA no período de 1970 a 2000, observando-se uma redução nos anos subseqüentes, cumprindo com as metas estabelecidas sob o programa vigente de controle da malária no Estado.The present study aims to describe malaria occurrence from 1970 to 2003 in the State of Amapá, Brazil. With positive films obtained from health agencies, temporal series on the annual parasite incidence - API (per 1,000 inhabitants were elaborated, taking into account population data available from the Brazilian Institute of Geography and Statistics. The results showed an increase in API values, although non-linear, related to the rapid population growth associated with regional economic and social development during the period, ranging from 15.1‰ in 1970 to 74.0‰ in 2000. Reversing this trend, a decrease appeared from 2001 onward, reaching a reduction of 50% in 2002. The results showed an increase in API values from 1970 to 2000, consistent with the incidence profile for malaria occurrence in the Amazon. A

  4. Opava (K. Ú. Kateřinky, Malé Hoštice, okres Opava). " Na hoštických lukách". Doba laténská. Sídliště. Záchranný výzkum.

    Czech Academy of Sciences Publication Activity Database

    Juchelka, Jiří

    2009-01-01

    Roč. 50, 1-2 (2009), s. 312 ISSN 1211-7250 Institutional research plan: CEZ:AV0Z80010507 Keywords : Czech Silesia * Malé Hoštice * Latén Cultur e Subject RIV: AC - Archeology, Anthropology, Ethnology

  5. L'evolució del rol dramàtic de la Bella Dorment i Malèfica a les adaptacions cinematogràfiques homònimes de 1959 i 2014

    OpenAIRE

    Escobar Pérez, Marina

    2015-01-01

    Aquest treball de recerca i investigació és el resultat d'un anàlisi qualitatiu i de gènere realitzat d'acord amb la teoria audiovisual narrativa i la teoria fílmica feminista sobre la representació cinematogràfica dels personatges de la Bella Dorment i Malèfica a les pel•lícules homònimes dels anys 1959 i 2014 amb l'objectiu de determinar l'evolució del seu rol dramàtic. Este trabajo de investigación es el resultado de un análisis cualitativo y de género realizado en base a la teoría audi...

  6. Associations between chewing lice (Insecta, Phthiraptera and albatrosses and petrels (Aves, Procellariiformes collected in Brazil Associações entre malófagos (Insecta, Phthiraptera e albatrozes e petréis (Aves, Procellariiformes capturados no Brasil

    Directory of Open Access Journals (Sweden)

    Michel P. Valim

    2006-12-01

    Full Text Available Chewing lice were searched on 197 skins of 28 species of procellariiform birds collected in Brazil. A total of 38 species of lice were found on 112 skins belonging to 22 bird species. The lice were slide-mounted and identified. A list of lice species found and their host species is given and some host-louse associations are discussed under an evolutionary perspective.Malófagos foram procurados em 197 peles de 28 espécies de aves Procellariiformes capturadas no Brasil. Um total de 38 espécies de piolhos foram encontradas em 112 peles pertencentes a 22 espécies de aves. Os piolhos foram montados em lâminas e identificados. Uma lista com as espécies de piolhos encontradas e seus hospedeiros é dada, além de algumas associações entre os piolhos e as aves serem discutidas sob uma perspectiva evolutiva.

  7. Malaria diagnosis and treatment under the strategy of the integrated management of childhood illness (IMCI): relevance of laboratory support from the rapid immunochromatographic tests of ICT Malaria P.f/P.v and OptiMal

    DEFF Research Database (Denmark)

    Tarimo, D S; Minjas, J N; Bygbjerg, I C

    2001-01-01

    to be excluded as a cause of illness (e.g. prior to treatment with toxic or expensive drugs, or during malaria epidemics). Wherever the effective drugs for the first-line treatment of malaria are cheap (e.g. chloroquine and Fansidar), treatment based on clinical diagnosis alone should prove cost-saving in health...... significantly associated with the P. falciparum asexual parasitaemias that equalled or exceeded the threshold intensity (2000/microl) that has the optimum sensitivity and specificity for the definition of a malarial episode. Diagnostic likelihood ratios (DLR) showed that a positive result in the OptiMal test....... Although the RIT may seem attractive for use in primary health facilities because relatively inexperienced staff can perform them, the high cost of these tests is prohibitive. In holo-endemic areas, use of RIT or microscopical examination of bloodsmears may only be relevant when malaria needs...

  8. Malária em usuários de drogas de administração endovenosa associada à soropositividade para HIV The association of malaria, HIV seropositivity and intravenous administration in drug users

    Directory of Open Access Journals (Sweden)

    Shin Shiang Lo

    1991-02-01

    Full Text Available Infecções induzidas de malária têm sido verificadas nos últimos anos no Estado de São Paulo, Brasil concomitantemente com o aumento de casos importados procedentes da região endêmica do país. Destaca-se o registro de um caso em 1988 e onze casos em 1989 de malária induzida por Plasmodium vivax, em indivíduos residentes na cidade de Presidente Prudente, situada a oeste do Estado e considerada uma das "portas de entrada" de pessoas procedentes da Região Amazônica. Os pacientes afirmaram não terem se deslocado recentemente ou negaram deslocamentos para áreas com possibilidade de transmissão de malária. Todos fizeram uso de drogas injetáveis, participando de círculos de conhecidos afins e geralmente dividiam a mesma agulha e seringa no uso da cocaína. Foi detectado o doente de malária que transmitiu inicialmente a doença ao caso de 1988, e a um primeiro grupo de três indivíduos em 1989. Destes três casos, um transmitiu a doença a outro grupo de dois indivíduos em 1989. A partir destas primeiras infecções e do uso continuado das drogas injetáveis entre grupos, surgiram dois novos casos e houve reinfecção em dois indivíduos (um destes apresentou duas reinfecções. O exame para detecção de HIV foi positivo em cinco indivíduos, um apresentou resultado negativo e não foi realizado em outros três indivíduos. São analisadas as informações desses casos e discutida a importância de sua ocorrência no momento atual.Cases of induced malaria have been notified in S. Paulo State, Brazil, in recent years. At the same time the number of cases imported from endemic regions of Brazil has been increasing. One case of induced malaria by Plasmodium vivax was registered in Presidente Prudente, located in the west of the State, in 1988 and a further eleven cases in 1989. This city is considered to be one of the main transit ports for people who come into the State from the Amazonian region. The patients declared that they had

  9. Avaliação nutricional, produção e incidência do mal-do-panamá em bananeira 'Prata-Anã' (AAB adubada com K, no quarto ciclo

    Directory of Open Access Journals (Sweden)

    José Tadeu Alves da Silva

    2013-12-01

    Full Text Available O presente trabalho teve como objetivos estimar a dose de K para obter a máxima eficiência física e econômica, estimar o nível crítico foliar de K e relacionar o equilíbrio nutricional da bananeira 'Prata-Anã' com a incidência de plantas com mal-do-panamá no 4º ciclo. O experimento foi realizado em Latossolo Vermelho-Amarelo (LVA, textura média, na região semiárida do norte de Minas Gerais, Brasil. Os tratamentos consistiram nas aplicações de quatro doses de K (0; 400; 800 e 1.200 kg ha-1 ano de K2O. Estes foram distribuídos em blocos ao acaso, com cinco repetições. A adubação com K promoveu aumento na produção da bananeira no 4º ciclo. A máxima eficiência física (31 Mg ha-1 e a econômica (30,5 Mg ha-1 foram obtidas com as aplicações de 969 e 707 kg ha-1 ano-1 de K2O, respectivamente. Os níveis críticos foliares de K obtidos foram 29,5 e 27,1 g kg-1, para a máxima eficiência física e econômica, respectivamente. O aumento das doses de K proporcionou melhor equilíbrio nutricional à bananeira e reduziu a porcentagem de plantas infestadas com o mal-do-panamá.

  10. A proposal for an evaluation model of pharmaceutical services for malaria Uma proposta de modelo de avaliação para a assistência farmacêutica na malária

    Directory of Open Access Journals (Sweden)

    Claudia Garcia Serpa Osorio-de-Castro

    2009-09-01

    Full Text Available Malaria is a serious public health problem in over 90 countries worldwide. In Brazil the disease is prevalent in the Amazon and the control rationale is based on early diagnosis and treatment. Quality pharmaceutical services are considered a key element for control. A proposal for evaluating pharmaceutical services for malaria is presented here. A theoretical outline composed of a logical model and an indicator framework is discussed and strives to establish a basis for assessment and judgment of the way in which these services are actually delivered. The aim is to contribute to the understanding of pharmaceutical services for malaria and other endemic diseases, complying with the directives of the Brazilian National Medicines Policy.A malária é um grave problema de saúde pública em cerca de 90 países. No Brasil, a Amazônia congrega o maior número de casos. No país, o racional de enfrentamento se baseia em diagnóstico precoce e tratamento. A assistência farmacêutica de qualidade é considerada elemento-chave para o controle da doença. Apresenta-se uma proposta de avaliação da assistência farmacêutica, composta por um modelo lógico e uma grade de indicadores, discutidos de modo a estabelecer uma base de comparação e julgamento da forma na qual os serviços são ofertados. O objetivo é contribuir para o entendimento da assistência farmacêutica na malária e em outras endemias, atendendo às diretrizes da Política Nacional de Medicamentos.

  11. Linguistic Norms at the Crossover: The Verbal Tenses and Modes, and the Structure of the Predicate in «Libro decimosexto» from Comentarios de erudición by Bartolomé Jiménez Patón

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    Juan Miguel Monterrubio Prieto

    2013-11-01

    Full Text Available This study examines verb modes and tenses as well as the predicate structure in «Libro decimosexto» of Bartolomé Jiménez Patón’s Comentarios de erudición in an effort to demonstrate how the text straddles the line between Medieval and Golden Age norms. Jiménez Patón, thus, combines traits already considered archaic at the time, due perhaps to his solid training in grammar and his linguistic awareness, with those modern solutions which, towards the end of the 1500’s, were forging the new Spanish language (that of the «plain style», which he championed, one that was gradually being refined in order to take its place as the language of culture.

  12. O Enigma do Mal: uma leitura do 'De casu diaboli'de Santo Anselmo (The enigma of evil: a reading of St. Anselm’s De casu diaboli - DOI: 10.5752/P.2175-5841.2013v11n32p1551

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    Manoel Luís Cardoso Vasconcellos

    2013-12-01

    Full Text Available O presente artigo quer investigar o problema do mal na perspectiva de Santo Anselmo, tomando como ponto de partida sua obra De casu diaboli, onde o tema é abordado, a partir da íntima ligação entre mal e pecado. Ao enfocar o mal na perspectiva da queda diabólica, o Doutor Magnífico intenta mostrar a conexão entre vontade, liberdade e justiça. Sua preocupação é investigar o significado moral da má escolha, realizada por uma criatura racional e puramente espiritual, feita boa e para ser boa. O pecado, consoante o autor, não está em almejar a felicidade, pois tal desejo é dádiva divina; o mal praticado pelo anjo está, precisamente, em querer a felicidade fora da justiça, isto é, ao querer ser feliz, ele foi de encontro ao que ele deveria ser: quis ser semelhante a Deus, extrapolando a sua própria natureza, pois ele desejou algo que, enquanto criatura, não caberia a ele almejar. Este é o ponto de partida para analisar o mal e sua mais dramática consequência, o sofrimento. Palavras-chave: Mal. Vontade. Justiça. Anselmo.   Abstract This article aims to investigate the problem of evil in Saint Anselm, especially in his treatise De casu diaboli. He approaches this issue from the close connection between evil and sin. Upon analyzing evil from the diabolic fall perspective, Dr. Magnificent tries to establish a connection between will, freedom and justice. This text investigates the moral meaning of misconduct, carried out by a rational and purely spiritual creature that was created good and meant to be good. Seeking for happiness is not itself a sin, according to the author, for such a wish is a gift from God. The evil done by the angel lies in the act of wanting happiness without justice, that is, on wanting to be happy, the angel contradicted what he was supposed to be: he wanted to be like God, transcending his own nature, as he wished for something that, as a creature, he was not fit to wish for. This is the starting point to

  13. Associação de eventos de vida produtores de estresse e mal-estar psicológico: um estudo de base populacional Association of stressful life events and psychological distress: a community-based study

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    Felipe Sparrenberger

    2004-02-01

    Full Text Available Foi realizado, em 1999, estudo transversal para investigar a associação entre determinados eventos produtores de estresse e a sensação de mal-estar psicológico. A Escala de Faces foi usada para medir o desfecho. A ocorrência de morte e doença em familiar, separação conjugal, roubo, acidente, migração e perda do emprego no ano anterior à entrevista, foi investigada entre 3.942 pessoas maiores de vinte anos de idade. A análise por regressão logística seguiu modelo hierárquico incluindo, no primeiro nível, características sócio-demográficas individuais; no segundo, eventos estressantes e, no terceiro, o mal-estar psicológico. Acidente e migração não se associaram ao desfecho. O maior efeito foi para separação conjugal (OR ajustada de 2,34. Os mais altos riscos atribuíveis na população foram os das variáveis sócio-econômicas (escolaridade 38,2% e renda 32,3% e o da ocorrência de pelo menos um dos eventos (36,4%. Atuação no plano das políticas públicas, visando a reduzir a ocorrência de eventos sociais negativos e, no plano individual, auxiliando as pessoas a lidar melhor com estes fatos da vida, poderiam contribuir para reduzir substancialmente a sensação de mal-estar psicológico.A cross-sectional study was conducted in 1999 to investigate the association between stressful psychosocial events and psychological distress. A Faces Scale was used to measure the outcome. Death and illness in the family, divorce, robbery, injury, migration, and loss of employment in the previous year were investigated through interviews with 3,942 individuals over 20 years. Logistic regression followed a hierarchical model using socio-demographic characteristics at the first level; psychosocial events at the second; and psychological distress at the third. Injury and migration were not associated with the outcome. The strongest effect was associated with divorce (adjusted OR = 2.34. The highest population-attributable risks were

  14. Comportamento epidemiológico da malária no Estado de Mato Grosso, 1980-2003 Epidemiological trends of malaria in the State of Mato Grosso, from 1980 to 2003

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    Marina Atanaka-Santos

    2006-04-01

    Full Text Available Descreveu-se a evolução temporal e espacial de malária em Mato Grosso, discriminadas em períodos de 1980-1985; 1986-1991; 1992-1997 e 1998-2003, distribuídas por microrregião homogênea. O índice parasitário anual do estado cresceu até 1992, reduzindo para 1,9 casos/mil habitantes em 2003; o coeficiente de mortalidade e a taxa de letalidade foram maiores nos anos de 1980 a 1989. Das 22 microrregiões, 13 apresentaram IPA inferior a 10 casos/1.000 habitantes em todos os períodos, ocorrendo concentração de casos nas microrregiões de Colíder, Alta Floresta, Aripuanã e Alto Guaporé. Em 2003, apenas a microrregião de Aripuanã persistia com IPA superior a 50 casos/1.000 habitantes. As microrregiões de Colíder, em 1983, 1985 a 1988 e 1990 e Alta Floresta, em 1991, apresentaram óbitos acima de 50/100.000 habitantes, sendo a maioria do sexo masculino, na faixa etária de 20 a 49 anos. A distribuição da doença por microrregiões evidenciou que a malária é predominantemente focal.The temporal and spatial evolution of malaria in Mato Grosso was determined in periods from 1980-1985, 1986-1991, 1992-1997 and 1998-2003 and distributed by homogeneous microregion. The annual parasitic index of the state rose until 1992 and then diminished to 1.9 cases/1,000 inhabitants in 2003, the ratio of mortality and the lethality rate were greater in the 1980s. Of the 22 microregions, 13 presented an API inferior to 10 cases/1,000 inhabitants in all periods. Cases were concentrated in the microregions of Colíder, Alta Floresta, Aripuanã and Alto Guaporé. In 2003, only the microregion of Aripuanã continued to present an API superior to 50 cases/1,000 inhabitants. The microregions of Colíder, in 1983, 1985 to 1988 and 1990 and Alta Floresta, in 1991 presented deaths over 50/100,000 inhabitants, mainly in males aged 20-49 years. The distribution of the disease in microregions showed that malaria is predominantly found in concentrated sites.

  15. Preliminary data from {gamma}-cardiography during the abatement of an asthmatic attack (1961); Premieres donnees de la {gamma}-cardiographie au decours de l'etat de mal asthmatique (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Georges, R; Vernejoul, P de; Raynaud, C; Blanchon, P; Kellershohn, C; Turiaf, J [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1961-07-01

    The authors used gamma cardiology during the abatement of 16 cases of asthma with a view to detecting heart attacks not otherwise visible with routine methods of examination: clinical, radiological and electro-cardio-graphical. In gamma cardiology, a radioactive indicator is used and its path followed in the cavities of the heart. The method makes it possible to study the circulation in the right heart, the pulmonary crossing, and the left heart, as well as evaluation of the heart-flow. As a result of their investigations the authors, after having discussed the significance of the data obtained with the method, suggest that it is possible by the use of gamma cardiography during the abatement of an asthma attack: 1- To confirm attacks of the right heart which have already been detected by ordinary methods. 2- To confirm the presence of modifications in the recorded curves which suggest, in the case of the left heart, possible attack; such on attack is also indicated, in a small number of cases, by electrocardiography curves. Some considerations are put forward by the authors concerning the physiopathology of attacks on the left heart. (authors) [French] Les auteurs ont fait appel a la gammacardiographie au decours de 16 cas d'etat de mal asthmatique, dans le but d'objectiver des atteintes cardiaques incapables d'etre revelees par les moyens d'exploration de routine: cliniques, radiologiques et electrocardiographiques. La gammacardiographie est un procede qui enregistre a l'aide d'un indicateur radioactif, le trajet de celui-ci dans les cavites cardiaques. Elle permet l'etude de la circulation dans le coeur droit, de la traversee pulmonaire, et le coeur gauche, de meme que le calcul du debit cardiaque. Au terme de leurs investigations, les auteurs apres avoir discute la signification des donnees fournies par la methode admettent que la gammacardiographie objective au secours de l'etat de mal asthmatique: 1- La confirmation de l'atteinte du coeur droit deja etablie

  16. Retardo no crescimento intrauterino, baixo peso ao nascer e prematuridade em recém-nascidos de grávidas com malária, na Colômbia Intrauterine growth retardation, low birth weight and prematurity in neonates of pregnant women with malaria in Colombia

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    Alberto Tobón-Castaño

    2011-06-01

    Full Text Available INTRODUÇÃO: É frequente a associação da malária com complicações como prematuridade, retardo no crescimento intrauterino, baixo peso ao nascer e mortalidade infantil, efeitos pouco estudados em áreas hipoendêmicas para malaria. O objetivo deste estudo foi analisar a relação da malária gestacional com estes efeitos em recém-nascidosnuma região endêmica para malária na Colômbia, entre 1993 e 2007. MÉTODOS: Foram estudadas as características em 1.716 recém-nascidos num estudo de coorte. Fez-se seguimento em 394 gestantes com malária (27% por Plasmodium falciparum e 73% por P. vivax e 1.322 sem malária. RESULTADOS: Foi encontrada uma relação entre a exposição à malária na gestação e o risco maior de baixo peso ao nascer (RR = 1,37; 1,03-1,83, assim como estatura baixa (RR = 1,52; 1,25-1,85, retardo no crescimento intrauterino (RR = 1,29; 1,0-1,66 e prematuridade (RR = 1,68; 1,3-2,17. A frequência de nascimentos prematuros foi maior nas mães com malária por P. falciparum (77% que aquelas com P. vivax (RR = 1,77; IC 95%: 1,2-2,6. CONCLUSÕES: O baixo peso ao nascer e o retardo no crescimento foi associado com malária na gestação na Colômbia. A infecção por P. vivax foi relacionada com efeitos adversos sobre o recém-nascido, de modo semelhante em relação ao P. falciparum.INTRODUCTION: Association between malaria and pregnancy complications, such as prematurity, intrauterine growth restriction, low birthweight and infant mortality has been reported. These effects have been studied widely in areas hyperendemic for malaria, but studies in low-endemic areas are scarce. The study investigated the relation between gestational malaria and low birthweight and intrauterine growth retardation in neonates of a malarial endemic region in Colombia, between 1993 and 2007. METHODS: The pattern of development in 1,716 neonates of women with and without malaria infection during pregnancy was evaluated in a cohort study. A

  17. Intervención familiar para el manejo psicológico en pacientes oncológicos con mal pronóstico en el hospital de la Misericordia

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    Ana Carolina Rodríguez Ibarra

    2004-01-01

    Full Text Available Se diseñó un programa fundamentado en el modelo cognitivo conductual de Inoculación de Estrés e intervención en duelo anticipatorio basado en cuatro tareas. El programa fue aplicado a tres pacientes con mal pronóstico del Servicio de Oncohematología del Hospital de la Misericordia y a sus familias. Por medio de estudio de caso, se describieron factores de riesgo y de protección así como respuestas frente a dicha intervención. El análisis cualitativo de casos arrojó la descripción de respuestas a pérdidas previas no elaboradas, pautas de comunicación deficiente en uno de los casos, y reconocimiento de apoyo al interior de cada familia. Según el reporte de los participantes, la intervención permitió la expresión de sentimientos, la reflexión sobre el sentido de la vida, incremento de posibilidades y habilidades de comunicación y orientación hacia la solución de problemas y toma de decisiones.

  18. Intrinsic magnetic properties of Sm{sub 2}Fe{sub 17-x}M{sub x}N{sub y}/C{sub y} (M=Al, Ga or Si)

    Energy Technology Data Exchange (ETDEWEB)

    Kubis, M.; Eckert, D.; Gebel, B.; Mueller, K.-H. E-mail: khm@ifw-dresden.de; Schultz, L

    2000-07-01

    Curie temperature T{sub c}, saturation polarization J{sub s} and anisotropy field H{sub a} of Sm{sub 2}Fe{sub 17-x}M{sub x}N{sub y}/C{sub y} with M=Al, Ga or Si (x{<=}3, y{approx}3) were determined by thermomagnetic measurements and a numerical fitting procedure of demagnetization curves. An increasing amount of the substitutional element M leads to an increase of T{sub c} of the Sm{sub 2}Fe{sub 17-x}M{sub x} parent compounds and generally to a decrease of T{sub c}, J{sub s} and H{sub a} for the interstitial nitrides and carbides. However, for small M contents, x{<=}1, an increased H{sub a} was observed compared to the substitution-free interstitial compounds. Gas-carburized and melt-carburized Sm{sub 2}Fe{sub 15}Ga{sub 2}C{sub y} samples showed large differences in J{sub s} and H{sub a} but identical T{sub c} values.

  19. Influence of M=Al, Ga and Si on microstructure and HDDR-processing of Sm2(Fe,M)17 and magnetic properties of their nitrides and carbides

    International Nuclear Information System (INIS)

    Kubis, M.; Gutfleisch, O.; Gebel, B.; Mueller, K.-H.; Schultz, L.

    1999-01-01

    Microstructural investigations by means of scanning electron microscopy and X-ray diffraction showed that the formation of high amounts of α-Fe in as-cast Sm 2 (Fe,M) 17 alloys can be suppressed by using the substitutions M=Al or Si together with excess Sm. Ga, on the other hand, does not induce this beneficial effect. The hydrogen absorption and desorption behaviour was investigated by temperature-pressure-analysis and hydrogen differential thermal analysis. Decreasing amounts of hydrogen were absorbed in Sm 2 (Fe,M) 17 for increasing contents of all substitutions M=Ga, Al and Si due to their stabilising effect on the 2:17 phase with regard to its disproportionation. Compared with the homogenised alloys, the as-cast materials show a weaker interstitial hydrogen absorption and a stronger disproportionation reaction at lower temperatures due to the higher content of Sm-rich phases in the as-cast alloys. A second cycle of the hydrogenation-disproportionation-desorption-recombination (HDDR) process leads to a faster disproportionation reaction at lower temperatures due to the grain refinement during the first cycle. Magnetic properties of as-cast and homogenised materials were investigated after HDDR treatment and nitrogenation or carburisation of pre-milled powders. Nitrogenated and carburised samples showed coercivities up to 3.0 T and 2.3 T, respectively. There were only slight differences of the magnetic properties of materials prepared from homogenised and from as-cast samples. (orig.)

  20. Evaluación de la válvula de Ahmed en el glaucoma de mal pronóstico quirúrgico Evaluation of Ahmed valve in the glaucoma of poor surgical prognosis

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    Francisco García González

    2001-12-01

    Full Text Available Se intervinieron 8 pacientes con glaucoma de mal pronóstico quirúrgico a los que se les implantaron una válvula de Ahmed con la técnica quirúrgica convencional. Se logró controlar la presión intraocular (PIO. Las complicaciones fueron: hipotonía (75 %, desprendimiento coroideo (37,5 %, hifema (25,0 %, contacto tubo iridiano (25, 0 %, hipotalamia (12,5 % y congestión en el área del implante (12,5 %. No hubo complicaciones intraoperatorias. Se obtuvieron resultados satisfactorios a mediano plazo.8 patients with glaucoma of poor surgical prognosis were implanted an Ahmed valve by using the conventional surgical technique. It was possible to control the intraocular pressure (IOP. The complications were: hypotony (75 %, choroidal detachment (37.5 %, hyphaemia (25.0 %, contact with the iridian tube (25.0 %, hypothalamia (12.5 % and congestion in the area of the implantation (12.5 %. There were no intraoperative complications. Medium term results were satisfactory.

  1. Ionic conductivity of the lithium titanium phosphate (Li/sub 1+x/M/sub x/Ti/sub 2-x/(PO/sub 4/)/sub 3/, M=Al, Sc, Y, and La) systems

    International Nuclear Information System (INIS)

    Aono, H.; Sugimoto, E.; Sadaaka, Y.; Imanaka, N.; Adachi, G.Y.

    1989-01-01

    High lithium ionic conductivity was obtained in Li/sub 1+X/M/sub X/Ti/sub 2-X/(PO/sub 4/)/sub 3/ (M=Al, Sc, Y, and La) systems. Lithium titanium phosphate, LiTi/sub 2/(PO/sub 4/)/sub 3/, is composed of both TiO/sub 6/ octahedra and PO/sub 4/ tetrahedra, which are linked by corners to form a three dimensional network, with a space group R3-barC. Some workers have already described that the conductivity increased considerably if Ti/sup 4+/ in LiTi/sub 2/(PO/sub 4/)/sub 3/ was substituted by slightly larger cations such as Ga/sup 3+/(1),Sc/sup 3+/(2), and In/sup 3+/(3,4). These results are similar to each other because of their close ionic radii. In this communication, substitution effects of Ti/sup 4+/ in LiTi/sub 2/(PO/sub 4/)/sub 3/ by various ions (Al/sup 3+/, Sc/sup 3+/, Y/sup 3+/, and La/sup 3+/) on their conductivities are reported

  2. Problematika zálohování a uchovávání dat v malých a středních podnicích

    OpenAIRE

    Hrach, Vlastimil

    2009-01-01

    Tato bakalářská práce upozorňuje na hojně opomíjenou důležitost firemních dat a jejich ochranu. Seznamuje s procesem zálohování jako základním prvkem bezpečnosti a efektivnosti informačního systému. Prezentuje výsledky mezinárodních studií na téma „Cena ztracených dat“, popisuje technologie diskových polí RAID, obecnou topologii LAN sítí a technologie DAS, NAS a SAN. Součástí práce jsou základní i pokročilé metody zálohování vhodné pro malé a střední podniky, v závislosti na jejich potřebě a ...

  3. The MAL-ED Cohort Study: Methods and Lessons Learned When Assessing Early Child Development and Caregiving Mediators in Infants and Young Children in 8 Low- and Middle-Income Countries

    Science.gov (United States)

    Murray-Kolb, Laura E.; Rasmussen, Zeba A.; Scharf, Rebecca J.; Rasheed, Muneera A.; Svensen, Erling; Seidman, Jessica C.; Tofail, Fahmida; Koshy, Beena; Shrestha, Rita; Maphula, Angelina; Vasquez, Angel Orbe; da Costa, Hilda P.; Yousafzai, Aisha K.; Oria, Reinaldo B.; Roshan, Reeba; Bayyo, Eliwasa B.; Kosek, Margaret; Shrestha, Sanjaya; Schaefer, Barbara A.; Bessong, Pascal; Ahmed, Tahmeed; Lang, Dennis

    2014-01-01

    More epidemiological data are needed on risk and protective factors for child development. In The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study, we assessed child development in a harmonious manner across 8 sites in Bangladesh, Brazil, India, Nepal, Pakistan, Peru, South Africa, and Tanzania. From birth to 24 months, development and language acquisition were assessed via the Bayley Scales of Infant and Toddler Development and a modified MacArthur Communicative Development Inventory. Other measures were infant temperament, the child's environment, maternal psychological adjustment, and maternal reasoning abilities. We developed standard operating procedures and used multiple techniques to ensure appropriate adaptation and quality assurance across the sites. Test adaptation required significant time and human resources but is essential for data quality; funders should support this step in future studies. At the end of this study, we will have a portfolio of culturally adapted instruments for child development studies with examination of psychometric properties of each tool used. PMID:25305296

  4. Biologia de anofelinos amazônicos: XII. Ocorrência de espécies de Anopheles, dinâmica da transmissão e controle da malária na zona urbana de Ariquemes (Rondônia

    Directory of Open Access Journals (Sweden)

    Wanderli Pedro Tadei

    1988-06-01

    Full Text Available Dados sobre o grau de incidência e distribuição de espécies Anopheles, em Ariquemes (RO, evidenciaram que a diversidade é maior na periferia da cidade e que Anopheles darlingi é registrada em praticamente todas as localidades de coleta. O inquérito entomológico revelou níveis diferentes de penetração da espécie na área urbana, podendo-se constatar que os Setores 1 e 3 são áreas livres de malária; Setores 2 e 4 mostram riscos na periferia; e a Área Industrial e Setor de Áreas Especiais, Conjunto BNH, Setor 5 e Vila Velha constituem áreas de alto risco da malária. Nestes últimos, os índices de mosquitos por homem/hora foram os mais elevados, observando-se variações no decorrer das amostragens e conforme a localização da área urbana. Medidas de densidade populacional revelaram mudanças estacionais, sendo os menores valores registrados no período de inverno. A transmissão da malária é discutida, considerando-se: 1 o papel da estrutura física da cidade, na época da fundação, 2 os igarapés que margeam a área urbana e suas relações com o ciclo de desenvolvimento dos anofelinos, 3 os padrões comportamentais da atividade de picar das espécies correlacionados a ambientes naturais e às áreas ecologicamente alteradas, e 4 a importância do manuseio ambiental no controle da malária, para redução da densidade populacional. Para conter o processo migratório do vetor é proposto um cinturão de proteção à cidade, constituído de mata não densa, incluindo também proteção biológica para incentivar a zoofilia dos anofelinos. Os resultados de infecção natural, obtidos em áreas de autoctonia da malária, permitem citar A. darlingi como vetor, sendo discutida a possibilidade de que outras espécies estejam envolvidas na transmissão.

  5. Eletromiografia laríngea e análise vocal em pacientes com Mal de Parkinson: estudo comparativo Laryngeal electromyography and acoustic voice analysis in Parkinson's disease: a comparative study

    Directory of Open Access Journals (Sweden)

    Ana Paula Zarzur

    2010-02-01

    Full Text Available A doença ou Mal de Parkinson se deve à deficiência dopaminérgica nos núcleos da base que geram alterações motoras. Comprometimento da comunicação verbal ocorre em 70 a 90% dos doentes. Existem poucas referências da aplicação da eletromiografia no estudo dos músculos laríngeos em pacientes com a doença de Parkinson. OBJETIVOS: Definir o padrão contrátil da musculatura intrínseca da laringe e sua correlação com a análise acústica vocal nos parkinsonianos. CASUÍSTICA E MÉTODO: Estudo prospectivo onde 26 adultos com o diagnóstico de Mal de Parkinson foram submetidos à eletromiografia laríngea e análise acústica vocal. Foram coletados potenciais de ação, tanto em repouso vocal quanto em fonação. Para a análise acústica da voz foram utilizados os programas VOXMETRIA® e GRAM 5.1.6®. RESULTADOS: O padrão eletromiográfico predominante no grupo estudo foi o de hipercontratibilidade (ou recrutamento aumentado durante repouso vocal que ocorreu em 73% dos indivíduos, sem que houvesse registro eletromiográfico de tremor. Quanto às características vocais, detectou-se a presença de tremor vocal no traçado do espectrograma (VOXMETRIA E GRAM e na avaliação perceptivo-auditiva em 69,5 % e 61 % dos sujeitos, respectivamente. CONCLUSÃO: O tremor vocal foi a característica acústica predominante no grupo estudado, sem que houvesse correlação eletromiográfica.Parkinson's disease (PD involves a progressive depletion of dopamine in the basal ganglia leading to motor alterations. Oral communication impairment occurs in 75% to 90% of patients and has been poorly studied. AIM: to asses laryngeal electromyography (LEMG patterns and correlate them to vocal analysis in patients with Parkinson's disease. MATERIALS AND METHODS: This is a prospective study. Twenty six adults with PD underwent laryngeal electromyography. Rest and phonation potentials were analyzed. VOXMETRIA® and GRAM 5.1.6. ® were used in acoustic analysis

  6. A crítica de Alexis Philonenko ao "mal-estar" sartriano: em defesa do humanismo The criticism of Alexis Philonenko to the sartrian's malaise: in defense of the humanism

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    Malcom G Rodrigues

    2010-01-01

    Full Text Available O objetivo do artigo é discutir a crítica de Philonenko (1981 aos conceitos sartrianos de "má-fé" e "liberdade". Um dos pilares dessa crítica é a defesa da noção de "coerência do estilo", elemento indispensável para resguardar a autenticidade tão prezada por Sartre, segundo Philonenko. Contudo, continua este último, ao afirmar "eu não sou jamais nenhuma de minhas condutas, nenhuma de minhas atitudes", Sartre limita a liberdade por ele defendida ao horizonte de uma maliciosa dissimulação, quer dizer, da má-fé. Nós constatamos três imprecisões nessa crítica. Em primeiro lugar, a citada afirmação de Sartre foi mal interpretada. Mas, em segundo, se essa interpretação está correta, supondo que o estilo seja indispensável à autenticidade, ainda assim a liberdade sartriana não pode ser "para o mal", pois ela se caracteriza, em termos ontológicos, como o próprio ser da realidade humana "em situação", e não em termos morais, como uma propriedade dessa realidade, cristalizada por um olhar atento sobre si ou sobre o outro, e julgada como boa ou má. Por fim, queremos concluir que, numa possível conduta autêntica, a derrocada da má-fé não apenas prescinde do amparo a uma coerência do estilo como também pressupõe o reconhecimento angustiante de sua gratuidade.The aim of this paper is to discuss the Philonenko's criticism (1981 to the sartrian's concepts of "bad-faith" and "freedom". One of the pillars of this criticism is to defend the notion of "coherence of style", an indispensable element to safeguard the authenticity so relevant for Sartre, according Philonenko. However, when Sartre says "I'm not ever any of my conduct, none of my actions", limits the freedom advocated by himself on the horizon of a malicious deception, that is, the horizon of bad- faith. We found three inaccuracies in this criticism. First, the statement aforementioned of Sartre was misinterpreted. But secondly, if this interpretation is correct

  7. Mal-Development of the Penis and Loss of Fertility in Male Rats Treated Neonatally with Female Contraceptive 17α-Ethinyl Estradiol: A Dose-Response Study and a Comparative Study with a Known Estrogenic Teratogen Diethylstilbestrol

    Science.gov (United States)

    Mathews, Ensa; Braden, Tim D.; Williams, Carol S.; Williams, John W.; Bolden-Tiller, Olga; Goyal, Hari O.

    2009-01-01

    The objectives of this study were to find a minimal dose of 17α-ethinyl estradiol (EE) that is detrimental to the developing penis and fertility and to compare estrogenic effects between EE and diethylstilbestrol (DES). Neonatal rats received EE at 10 ng (1 μg/kg), 100 ng, 1 μg, or 10 μg per pup on alternate days from postnatal days 1 to 11 (dose-response study) or received EE or DES at 100 ng per pup daily from postnatal days 1 to 6 (comparative study). Effects of EE were dose dependent, with ≥ 100-ng dose inducing significant (p penis was malformed, characterized by underdeveloped os penis and accumulation of fat cells. Fertility was 0% in the ≥ 1-μg groups, in contrast to 60% in the 100-ng group and 100% in the 10-ng and control groups. Animals treated with ≥ 10 ng had significant reductions in the weight of bulbospongious muscle, testis, seminal vesicle, epididymal fat pad, and in epididymal sperm numbers. A comparison of EE and DES effects showed similar reductions in penile weight and length and the weight of bulbospongiosus muscle, testis, seminal vesicle, epididymis, and epididymal fat pad in both adolescent and adult rats. While 5/6 control males sired, only 1/6 in the EE group and 0/6 in the DES group sired. Hence, neonatal exposure to EE at 10 ng (environmentally relevant dose) adversely affects male reproductive organs. A dose ten times higher than this leads to permanently mal-developed penis and infertility. Furthermore, EE and DES exposures show similar level of toxicity to male reproductive organs. PMID:19729556

  8. Influence of M=Al, Ga and Si on microstructure and HDDR-processing of Sm{sub 2}(Fe,M){sub 17} and magnetic properties of their nitrides and carbides

    Energy Technology Data Exchange (ETDEWEB)

    Kubis, M.; Gutfleisch, O.; Gebel, B.; Mueller, K.-H.; Schultz, L. [Institut fuer Festkoerper- und Werkstofforschung Dresden e.V. (Germany). Inst. fuer Metallische Werkstoffe; Harris, I.R. [School of Metallurgy and Materials, University of Birmingham, Birmingham, B15 2TT (United Kingdom)

    1999-02-01

    Microstructural investigations by means of scanning electron microscopy and X-ray diffraction showed that the formation of high amounts of {alpha}-Fe in as-cast Sm{sub 2}(Fe,M){sub 17} alloys can be suppressed by using the substitutions M=Al or Si together with excess Sm. Ga, on the other hand, does not induce this beneficial effect. The hydrogen absorption and desorption behaviour was investigated by temperature-pressure-analysis and hydrogen differential thermal analysis. Decreasing amounts of hydrogen were absorbed in Sm{sub 2}(Fe,M){sub 17} for increasing contents of all substitutions M=Ga, Al and Si due to their stabilising effect on the 2:17 phase with regard to its disproportionation. Compared with the homogenised alloys, the as-cast materials show a weaker interstitial hydrogen absorption and a stronger disproportionation reaction at lower temperatures due to the higher content of Sm-rich phases in the as-cast alloys. A second cycle of the hydrogenation-disproportionation-desorption-recombination (HDDR) process leads to a faster disproportionation reaction at lower temperatures due to the grain refinement during the first cycle. Magnetic properties of as-cast and homogenised materials were investigated after HDDR treatment and nitrogenation or carburisation of pre-milled powders. Nitrogenated and carburised samples showed coercivities up to 3.0 T and 2.3 T, respectively. There were only slight differences of the magnetic properties of materials prepared from homogenised and from as-cast samples. (orig.) 21 refs.

  9. The LPi and LPi/2 Propositional and Predicate Logics

    Czech Academy of Sciences Publication Activity Database

    Cintula, Petr

    2001-01-01

    Roč. 124, č. 3 (2001), s. 289-302 ISSN 0165-0114 Institutional research plan: AV0Z1030915 Keywords : fuzzy logic * product logic * Lukasiewicz logic Subject RIV: BA - General Mathematics Impact factor: 0.470, year: 2001

  10. Identification of the Predicator Variables of Candidate Teacher Teaching Motivations

    Science.gov (United States)

    Bozpolat, Ebru

    2016-01-01

    The purpose of this study was to determine whether the internal and external teaching motivations of 3rd and 4th year students of the Faculty of Education of Cumhuriyet University are predicted by the variables of gender, department, year level, conscious preference of department they are studying in, whether there is a teacher in their family,…

  11. Linear Model for Optimal Distributed Generation Size Predication

    Directory of Open Access Journals (Sweden)

    Ahmed Al Ameri

    2017-01-01

    Full Text Available This article presents a linear model predicting optimal size of Distributed Generation (DG that addresses the minimum power loss. This method is based fundamentally on strong coupling between active power and voltage angle as well as between reactive power and voltage magnitudes. This paper proposes simplified method to calculate the total power losses in electrical grid for different distributed generation sizes and locations. The method has been implemented and tested on several IEEE bus test systems. The results show that the proposed method is capable of predicting approximate optimal size of DG when compared with precision calculations. The method that linearizes a complex model showed a good result, which can actually reduce processing time required. The acceptable accuracy with less time and memory required can help the grid operator to assess power system integrated within large-scale distribution generation.

  12. Metaphysical Modality, Modality of Predicate and the Theory of

    Directory of Open Access Journals (Sweden)

    l nabavi

    2010-05-01

    This paper discusses the historical overview of the metaphysical modality firstly and then shows that the theory of "Decisive Necessity” is true and justified in a model of modal logic with equivalent accessibility relation and homogeneous possible world view (fixed domain.

  13. Predication of Crane Condition Parameters Based on SVM and AR

    International Nuclear Information System (INIS)

    Xu Xiuzhong; Hu Xiong; Zhou Congxiao

    2011-01-01

    Through statistic analysis of vibration signals of motor on the container crane hoisting mechanism in a port, the feature vectors with vibration are obtained. Through data preprocessing and training data, Training models of condition parameters based on support vector machine (SVM) are established. The testing data of condition monitoring parameters can be predicted by the training models. During training the models, the penalty parameter and kernel function of model are optimized by cross validation. In order to analysis the accurate of SVM model, autoregressive model is used to predict the trend of vibration. The research showed the predicted results of model using SVM are better than the results by autoregressive (AR) modeling.

  14. Herbaceous biomass predication from environmental and remote sensing indicators

    CSIR Research Space (South Africa)

    Dudeni-Tlhone, N

    2012-11-01

    Full Text Available Feeding patterns and distribution of herbivores animals are known to be influenced by quality and quantity of forage such as grass. Modelling indicators of grass quality and biomass are critical in understanding such patterns and for decision makers...

  15. Verification using Satisfiability Checking, Predicate Abstraction, and Craig Interpolation

    Science.gov (United States)

    2008-09-01

    297, 2007. 4.10.1 196 [48] Roberto Bruttomesso, Alessandro Cimatti, Anders Franzen, Alberto Grig- gio, Ziyad Hanna, Alexander Nadel, Amit Palti, and...using SAT based conflict analysis. In Formal Methods in Computer Aided Design, pages 33–51, 2002. 1.1, 7 [54] Alessandro Cimatti, Alberto Griggio, and...and D. Vroon. Automatic memory reductions for RTL-level verification. In ICCAD, 2006. 1.2.4, 6.2, 7 [108] Joao P. Marques-Silva and Karem A. Sakallah

  16. MRI in predication of early hemorrhagic transformation after acute stroke

    International Nuclear Information System (INIS)

    Guo Gang; Wu Renhua; Mikulis, D.J.

    2007-01-01

    Objective: To investigate the relationship among early parenchymal enhancement, post- gadolinium (Gd) hyperintense middle cerebral artery (HMCA), and subsequent hemorrhagic transformation (HT) in patients with hyperacute ischemic stroke. Methods: Twenty-four consecutive patients with ischemic stroke who underwent MRI within 6 h [(4.3±1.4) h] of symptom onset were retrospectively reviewed. All of these patients underwent at least one follow-up MRI or non-enhanced CT study at 2 to 7 days. Post-Gd T 1 WI were analyzed for parenchymal enhancement and hyperintense MCA. Gradient echo MRI and CT were used for assessment of HT. Results: Ten patients developed HT on follow-up imaging (hemorrhagic group). Early parenchymal enhancement was found in 6 patients with HT (P 1 WI after Gd-DTPA administration are independent predictors of subsequent HT. (authors)

  17. Predicate Transformers for Recursive Procedures with Local Variables

    NARCIS (Netherlands)

    Hesselink, Wim H.

    1999-01-01

    The weakest precondition semantics of recursive procedures with local variables are developed for an imperative language with demonic and angelic operators for unbounded nondeterminate choice. This does not require stacking of local variables. The formalism serves as a foundation for a proof rule

  18. Derived rules for predicative set theory: An application of sheaves

    NARCIS (Netherlands)

    van den Berg, B.; Moerdijk, I.

    2012-01-01

    We show how one may establish proof-theoretic results for constructive Zermelo–Fraenkel set theory, such as the compactness rule for Cantor space and the Bar Induction rule for Baire space, by constructing sheaf models and using their preservation properties.

  19. Predicating magnetorheological effect of magnetorheological elastomers under normal pressure

    International Nuclear Information System (INIS)

    Dong, X; Qi, M; Ma, N; Ou, J

    2013-01-01

    Magnetorheological elastomers (MREs) present reversible change in shear modulus in an applied magnetic field. For applications and tests of MREs, a normal pressure must be applied on the materials. However, little research paid attention on the effect of the normal pressure on properties of MREs. In this study, a theoretical model is established based on the effective permeability rule and the consideration of the normal pressure. The results indicate that the normal pressure have great influence on magnetic field-induced shear modulus. The shear modulus of MREs increases with increasing normal pressure, such dependence is more significant at high magnetic field levels.

  20. The skull of Wolfgang Amadeus Mozart predicates of his death.

    Science.gov (United States)

    Vlcek, E; Druga, R; Smahel, Z; Bigoni, L; Velemínská, J

    2006-01-01

    W. A. Mozart died due to the consequences of chronic epidural hematoma after sustaining a dull injury to his head, probably at an early age. Exacerbation of the process was repeated over a period of many years and manifested itself as pyrexial disease, meningeal irritation with intense headaches. After the attack subsided, the illness manifested itself again. After the last attack of the likely infected nidus, Mozart died on December 5, 1791. Historic data about the composer's behavior indicate development of a temporal syndrome or temporal epilepsy with typical clinical manifestations.

  1. Children's Comprehension of Plural Predicate Conjunction

    Science.gov (United States)

    Tieu, Lyn; Romoli, Jacopo; Poortman, Eva; Winter, Yoad; Crain, Stephen

    2018-01-01

    Previous developmental studies of conjunction have focused on the syntax of phrasal and sentential coordination (Lust, 1977; de Villiers, Tager-Flusberg & Hakuta, 1977; Bloom, Lahey, Hood, Lifter & Fiess, 1980, among others). The present study examined the flexibility of children's interpretation of conjunction. Specifically, when two…

  2. A importância do perfil clínico-laboratorial no diagnóstico diferencial entre malária e hepatite aguda viral Importance of clinical and laboratory profiles for the differential diagnosis of malaria and acute viral hepatitis

    Directory of Open Access Journals (Sweden)

    Cacyane Naiff do Amaral

    2003-10-01

    Full Text Available OBJETIVOS: Destacar o perfil clínico-laboratorial de malária e hepatite aguda viral em dois grupos de crianças, ressaltando semelhanças e diferenças entre os dois quadros; subsidiar o aumento da sensibilidade clínica de presunção diagnóstica precoce de malária na infância. MÉTODOS: Foram estudados dois grupos de 30 crianças, de dois a dez anos de idade, portadoras de primo infecção malárica ou hepatite viral aguda, confirmados pela pesquisa de plasmódio e pesquisa de marcadores virais de hepatite A e B. As crianças foram submetidas às seguintes avaliações no primeiro dia de atendimento: hemograma, contagem de plaquetas, dosagem de enzimas hepáticas, uréia, creatinina e bilirrubinas. Os achados clínicos e laboratoriais foram descritos e comparados entre os dois grupos. Proporções de indivíduos com exames físicos alterados foram comparadas nos dois grupos, pelo teste exato de Fisher. RESULTADOS: A apresentação clínica inicial da doença foi semelhante em todos os pacientes: febre, cefaléia, sintomas digestivos e colúria. Metade dos portadores de malária não apresentou a tríade clássica, apesar de todos terem apresentado febre moderada ou alta, ao contrário dos portadores de hepatite. Na avaliação laboratorial, os portadores de malária apresentaram mais anemia e plaquetopenia quando comparados aos portadores de hepatite. Foram marcantes, nos portadores de hepatite, as elevações de bilirrubinas e enzimas hepáticas. CONCLUSÕES: A propedêutica detalhada e a avaliação criteriosa dos exames laboratoriais inespecíficos constituem peças fundamentais para a diferenciação clínica entre os dois diagnósticos, reforçando a identificação precoce do parasita e, conseqüentemente, o tratamento rápido de malária em crianças.OBJECTIVE: To establish clinical and diagnostic findings of malaria and acute viral hepatitis in children, stressing similarities and differences, so as to enhance the sensitivity of

  3. The MAL-ED study: a multinational and multidisciplinary approach to understand the relationship between enteric pathogens, malnutrition, gut physiology, physical growth, cognitive development, and immune responses in infants and children up to 2 years of age in resource-poor environments.

    Science.gov (United States)

    2014-11-01

    Highly prevalent conditions with multiple and complex underlying etiologies are a challenge to public health. Undernutrition, for example, affects 20% of children in the developing world. The cause and consequence of poor nutrition are multifaceted. Undernutrition has been associated with half of all deaths worldwide in children aged Malnutrition and the Consequences for Child Health (MAL-ED) Study, led by the Fogarty International Center of the National Institutes of Health and the Foundation for the National Institutes of Health, has been established at sites in 8 countries with historically high incidence of diarrheal disease and undernutrition. Central to the study is the hypothesis that enteropathogen infection contributes to undernutrition by causing intestinal inflammation and/or by altering intestinal barrier and absorptive function. It is further postulated that this leads to growth faltering and deficits in cognitive development. The effects of repeated enteric infection and undernutrition on the immune response to childhood vaccines is also being examined in the study. MAL-ED uses a prospective longitudinal design that offers a unique opportunity to directly address a complex system of exposures and health outcomes in the community-rather than the relatively rarer circumstances that lead to hospitalization-during the critical period of development of the first 2 years of life. Among the factors being evaluated are enteric infections (with or without diarrhea) and other illness indicators, micronutrient levels, diet, socioeconomic status, gut function, and the environment. MAL-ED aims to describe these factors, their interrelationships, and their overall impact on health outcomes in unprecedented detail, and to make individual, site-specific, and generalized recommendations regarding the nature and timing of possible interventions aimed at improving child health and development in these resource-poor settings. Published by Oxford University Press on

  4. La desaparición forzada de personas: análisis crítico del derecho administrativo colombiano a través de los estándares del sistema interamericano de protección de derechos humanos. Estudio de caso de los mal llamados “falsos positivos”

    OpenAIRE

    Quintero Mendoza, Juan Sebastián

    2016-01-01

    La categorización jurídica de los mal llamados “falsos positivos” en Colombia es un tema controversial: en algunas ocasiones se habla de ejecuciones extrajudiciales, otras veces de homicidio en persona protegida y en otros casos de desapariciones forzadas, dependiendo de la institución que juzgue los casos. Ahora bien, al no existir unidad de criterios en la categorización jurídica de los “falsos positivos”, se hace imprescindible la integración de conceptos en torno a entender dichos hechos...

  5. Construindo o estado de conhecimento do bem-estar e mal-estar docente na revista de educação da PUCRS = Building the state of knowledge of teachers well-being and burnout in "Revista Educação" of PUCRS

    Directory of Open Access Journals (Sweden)

    Pinheiro, Leandro Brum

    2011-01-01

    Full Text Available A imprensa atual tem retratado diversas situações de professores e alunos em alto nível de mal-estar: stress, violência, rendimento baixo nas avaliações institucionais, perda do valor da profissão docente, entre outros. Todavia, a Academia tem resgatado também as diversas tentativas de compreensão e promoção do bem-estar na escola. A Pontifícia Universidade Católica do Rio Grande do Sul, através da Revista Educação, tem tratado destes dois temas com séria análise contextual e profundidade científica, sendo por isso escolhida como a fonte de pesquisas deste artigo. Com o fim de analisar a construção do estado de conhecimento do bem-estar e mal-estar docente na citada revista, tomamos desde o primeiro caderno publicado (1978 até o mais recente (2009, selecionando os artigos sobre as temáticas e organizando-os em seis categorias: a década em que foi escrito, os autores e suas universidades de origem, a classificação dos artigos em resultados de pesquisa ou de revisão bibliográfica, os autores mais citados e a temática dominante – o bem-estar ou o mal-estar docente. A partir das categorizações levantadas para os nove artigos selecionados, observou-se que a produção destes começou a se tornar mais frequente a partir dos anos 90, em especial com contribuições de professores da PUCRS e da Universidade do Algarve – Portugal. A maioria destes artigos era de revisão bibliográfica. Outra conclusão importante é que houve, a partir do início desta década, uma preocupação maior com o bem-estar docente do que propriamente com o mal-estar docente. Assim, é nosso desejo que este artigo possa promover futuras pesquisas nesta área, enfatizando o bem-estar dos professores, consolidando a tendência mundial das publicações sobre o tema

  6. Prescrições para tratamento de malária não complicada em gestantes na Amazônia Legal: evidências do Projeto Mafalda*

    Directory of Open Access Journals (Sweden)

    Tatiana Chama Borges Luz

    2013-06-01

    Full Text Available Objetivos: Avaliar prescrições de antimaláricos segundo indicadores de qualidade e descrever relatos de eventos adversos entre gestantes com malária não complicada. Métodos: Estudo descritivo de prontuários de gestantes maiores de 15 anos, residentes em municípios de alto risco na Amazônia Legal. Antimaláricos caracterizados segundo frequência de prescrição, tipo de plasmódio e de unidade de saúde de atendimento, e de possíveis eventos adversos. Para comparação das variáveis estudas utilizou-se o teste do qui-quadrado de Pearson. Resultados: Foram avaliados 262 prontuários de gestantes. A maioria das gestantes pesquisadas recebeu diagnóstico de infecção por P. vivax (71,2%. Cloroquina foi o fármaco mais prescrito (65,6%. Fármacos não recomendados foram encontrados em 9,0% e 16,2% das prescrições para P. vivax e P. falciparum , respectivamente. Prescrições para P. falciparum , em proporção significativamente maior, contiveram esquemas e posologia e/ou duração do tratamento não adequados ao protocolo oficial (p = 0,001, bem como sem especificação da posologia (p = 0,004. Não houve diferenças significativas entre hospitais de referência e unidades básicas de saúde quanto aos esquemas de tratamento, proporções de prescrições contendo esquemas de tratamento não adequados e sem especificação da posologia. Cloroquina foi o fármaco mais envolvido em ocorrências de eventos adversos. Conclusões: Os resultados mostraram deficiências na prescrição de antimaláricos para gestantes, especialmente quanto à adequação ao protocolo oficial.

  7. Mal-estar, sofrimento e sintoma: releitura da diagnóstica lacaniana a partir do perspectivismo animista Discontent, suffering and symptom: a Lacanian diagnostic re-reading via animist perspectivism

    Directory of Open Access Journals (Sweden)

    Christian Ingo Lenz Dunker

    2011-01-01

    Full Text Available O objetivo deste artigo é apresentar a noção de forma de vida como conceito útil para a recontextualização da diagnóstica psicanalítica, decorrente dos trabalhos de Jacques Lacan, no quadro da metadiagnóstica da modernidade, desenvolvida pelas teorias sociais, especialmente as de extração crítica. Para justificar a utilidade clínica e crítica do conceito de forma de vida vamos realizar uma redescrição das oposições fundamentais da diagnóstica psicanalítica (falta e excesso, produção e improdução, determinação e indeterminação, consideradas, respectivamente, como derivativos da esfera do desejo, da linguagem e do trabalho. Para tanto, propomos uma homologia entre a psicopatologia psicanalítica e a noção de perspectivismo ameríndio, desenvolvida por Viveiros de Castro (2002, que adquire neste trabalho uma dupla finalidade: 1 responder a críticas dirigidas ao estruturalismo lacaniano em psicopatologia; e 2 justificar a distinção entre sintoma, sofrimento e mal-estar.The objective of this article is to explore the notion of life form as a useful concept for recontextualizing psychoanalytic diagnosis, as inspired by the works of Jacques Lacan, within the framework of the metadiagnosis of modernity developed by social theories, especially those of a critical inclination. To justify the clinical and critical utility of the concept of life form, the text embarks on a re-description of the fundamental oppositions of psychoanalytic diagnosis (lack and excess, production and non-production, determination and indetermination as derived from the spheres of desire, language and work respectively. This aim in mind, the text proposes a homology between psychoanalytic psychopathology and the notion of Amerindian perspectivism developed by Viveiros de Castro (2002, which assumes a double purpose in this work: (1 to respond to critiques of Lacanian structuralism in psychopathology; and (2 to justify the distinction between

  8. Photoelectric guided AGV based on MC9S12XS128MAL%基于MC9S12XS128MAL控制的光电导引式AGV

    Institute of Scientific and Technical Information of China (English)

    刘波; 汪宇辰; 梁伟健; 叶波; 周杰

    2013-01-01

    Aiming at the drawbacks that automatic guided vehicles (AGV) are bulky and expensive,a system based on Freescale micro processor Mc9S12XS128MAL was used to design the economic photoelectric guided AGV system with the sophisticated intelligent car racing of the Froescale cup and the cheep electric wheelchairs.Experimental study on the ultrosonic sensors was carried out on a test rig.The obastacle distance in emergency was measured experimentally.The LCD module was introduced to display the real time velocity with using photoelectric encoders.Two brushless DC motors were used to drive the wheels,the deviation accumulated algorithm was proposed,The function was realized that the brushless DC motors successfully drive the AGV forward and to turn through differential control.At last,the control method was validated in the experiment.The results indicate that the AGV system is of quick dynamic response and stable operation,and the automatic control of the AGV is excellently realized.%针对目前国内自动导引运输车(AGV)体积大、价格贵的问题,在技术成熟的“飞思卡尔”智能汽车竞赛和价格低廉的电动轮椅车的基础上,设计了一款基于“飞思卡尔”MC9S12XS128MAL微处理器控制的经济型光电导引式AGV系统.在试验台上对超声波传感器进行了测试,确定了紧急情况下的避障距离;采用光电码盘测速,由液晶模块显示出AGV的实时速度;同时结合无刷直流电机驱动原理,提出了基于偏差累积算法的控制方法,实现了差动方式的无刷直流电机驱动AGV直线行驶和转弯的功能,最后通过实验验证了该控制方法的有效性.研究结果表明,此AGV系统响应迅速、运行稳定,很好地实现了AGV的自动控制.

  9. Quantification of Internal Stress-Strain Fields in Human Tendon: Unraveling the Mechanisms that Underlie Regional Tendon Adaptations and Mal-Adaptations to Mechanical Loading and the Effectiveness of Therapeutic Eccentric Exercise

    Science.gov (United States)

    Maganaris, Constantinos N.; Chatzistergos, Panagiotis; Reeves, Neil D.; Narici, Marco V.

    2017-01-01

    of the stress created by the exercise and is not only reliant upon the type of muscle contraction performed. To better understand the micromechanical behavior and regional adaptability/mal-adaptability of tendon tissue it is important to estimate its internal stress-strain fields. Recent relevant advancements in numerical techniques related to tendon loading are discussed. PMID:28293194

  10. The MAL: A Malware Analysis Lexicon

    Science.gov (United States)

    2013-02-01

    grandfather, James Murray, and his heroic, Victorian project to build the first edition of the Oxford English Dictionary. He recruited a network of...code to ensure that the binaries in question have not been altered. binary registry pattern matching The practice of searching the binary of an...artifact for particular patterns indicative of certain properties.6 bit flipping A technique used in fuzzers that randomly inverts a single bit in

  11. Case 1432: MAL 8(1)

    DEFF Research Database (Denmark)

    Lookofsky, Joseph

    2014-01-01

    This publication reports a decision by the Supreme Court (Højesteret) of Denmark, 22 juni 2012 in case 210/2011 (1. afd.). Dregg v. Chr. Jensen Shipping. Published in Danish: Ugeskrift for Retsvæsen 2012 p. 3001 et seq. The decision relates to the U.N. Model Arbitration Law and the...

  12. Brasil: un arte popular mal comunicado

    Directory of Open Access Journals (Sweden)

    Dilma De Mela Silva

    2015-01-01

    Full Text Available En "Auge y caída de los vÍdeo juegos" el autor señala que las tecnologías digitales cambian aceleradamente. Cada cambio impacta en el entorno de la sociedad y la cultura ¿Cómo adaptarse a estos retos? ¿Cómo controlarlos? se responde en el artículo. Otro artículo hace alusión a la conmemoración de los 10 años de la Declaración del Nuevo Orden Internacional de la Información y Comunicación - NOIIC-. Radio boletín informativo para niños cita las recomendaciones dadas en el Seminario realizado por el CIESPAL, la O E A , Radio Nederland y la Fundación Friedrich E. y confirma la necesidad de que si se va a comunicar a los niños, es necesario capacitarse. Se analiza el decálogo del comunicador infantil, enfatizando en que los niños valen y exigen. "Avances psicológicos de la publicidad" es un resumen del libro de William Meyers "Los creadores de imagen" trata básicamente del poder de persuasión de Madison Avenue en sus campañas publicitarias y explica la cultura consumista en Estados Unidos, luego de la segunda guerra Mundial.

  13. Der Schmatzomat – Schokolade mal anders verpacken

    OpenAIRE

    Braun, Meike; Hochstein, Maximilian; Furmans, Kai

    2014-01-01

    Am Institut für Fördertechnik und Logistiksysteme (IFL) wurde zur Unterstützung und Entlastung der behinderten und nicht behinderten Mitarbeiter der Ostalb-Werkstätten der Samariterstiftung eine Apparatur zur Verpackung von Schokoladenriegeln entwickelt. Grundlage des „Schmatzomaten“ sind dabei rein mechanische Prinzipien, die den Durchsatz der verpackten Schokoladenriegel (des „Schmatz“) erhöhen, gleichzeitig aber auch zu einer Erleichterung des Gesamtprozess führen. At Institut für Förde...

  14. Fenomena Mal bagi Masyarakat Urban di Jakarta

    Directory of Open Access Journals (Sweden)

    Amarena Nediari

    2013-04-01

    Full Text Available Mall building is a place where urban communities come together with their specific interest. People go to the mall with their independent needs without any emotional bonding between each other. As a public space, mall is trying to meet the needs of urban communities especially as an entertaining space for the visitors. Go to the mall has become a way of life in urban society, as a destination for the whole family. While on the other hand the existence of many mall building are the traits of sick city, because as a public space, city does not meet the social and environmental objectives anymore. Jakarta has more than 75 building mall, it has exceeded the limit of the population. Mall has become a phenomenon because it has met the lifestyle of urban society but on the other side mall has spent water absorption area. This disagreement about mall building requires a mall that friendly to the environment, so that the green open spaces and water absorption area can be provided or replaced as well. The next discussion is about mall that should build friendly to the environment and its importance to the urban community. 

  15. Le mal et ses complots imaginaires

    OpenAIRE

    Frankfurter, David

    2012-01-01

    Les récits d’abus rituels sataniques que les médias ont largement diffusés, aux États-Unis et au Royaume-Uni, entre le début des années 1980 et la fin des années 1990, soutenaient le parallèle avec les allégations avancées, durant l’Antiquité et au début des Temps modernes, contre les chrétiens, les hérétiques, les juifs ou les sorcières. Quelle est la nature de ces parallèles ? Cet article examine plusieurs types de modèles convoqués lors de diverses occurrences historiques des peurs panique...

  16. Brasil: un arte popular mal comunicado

    OpenAIRE

    Dilma De Mela Silva

    2015-01-01

    En "Auge y caída de los vÍdeo juegos" el autor señala que las tecnologías digitales cambian aceleradamente. Cada cambio impacta en el entorno de la sociedad y la cultura ¿Cómo adaptarse a estos retos? ¿Cómo controlarlos? se responde en el artículo. Otro artículo hace alusión a la conmemoración de los 10 años de la Declaración del Nuevo Orden Internacional de la Información y Comunicación - NOIIC-. Radio boletín informativo para niños cita las recomendaciones dadas en el Seminario realizado po...

  17. Oxygen minimum seafloor ecological (mal) functioning

    Digital Repository Service at National Institute of Oceanography (India)

    Moodley, L.; Nigam, R.; Ingole, B.S.; PrakashBabu, C.; Panchang, R.; Nanajkar, M.; Sivadas, S.; van Breugel, P.; van Ijzerloo, L.; Rutgers, R.; Heip, C.H.R.; Soetaert, K.; Middelburg, J.J.

    OM transformation is hampered (“batteries not included”, Lane 2006) resulting in rapid/immediate OM transfer out of the fast- biological cycle into the “slow (geological)” carbon cycle. From a biogeochemical point of view, the question of what..., N., 2006. Batteries not included, what can’t bacteria do? Nature, 441, 274-277. Law, G.T.W., Shimmield, T.M., Shimmield, G.B., Cowie, G.L. Breuer, E.R., Harvey, S.M., 2009. Manganese, iron, and sulphur cycling on the Pakistan margin. Deep Sea...

  18. PENGARUH KEBUDAYAAN KONTEMPORER DALAM PERANCANGAN ARSITEKTUR MAL

    OpenAIRE

    Freddy H. Istanto

    2000-01-01

    Market is traditionally known as the place where the seller and the buyers meet. In its development, it grows to be big shopping centers and even malls. Along with it, the concept of market has also changed within this building. It is not only the place where the transaction between the sellers and the buyers happen but also it expands to be the one where each person has turned to be the "player" in the nowadays "cultural-theatre". Being the designers, the architect is challenged to respond t...

  19. REPRESENTACIÓN DE RELACIONES SEMÁNTICAS ENTRE PROBLEMAS Y OBJETIVOS MEDIANTE LÓGICA DE PREDICADOS REPRESENTAÇÃO DE RELACIONAMENTOS SEMÁNTICOS ENTRE PROBLEMAS E OBJETIVOS MEDIANTE LÓGICA DE PREDICADOS PREDICATE-LOGIC-BASED REPRESENTATION OF SEMANTIC RELATIONSHIPS BETWEEN GOALS AND PROBLEMS

    Directory of Open Access Journals (Sweden)

    Carlos Mario Zapata

    2011-06-01

    Full Text Available El mundo organizacional siempre tendrá objetivos que alcanzar y se encontrará en el camino obstáculos que dificultan su consecución. El primer paso para resolver problemas y establecer objetivos es identificarlos y representarlos, lo cual casi siempre se hace por medio del lenguaje natural, evidenciando la carencia de métodos formales para el planteamiento de sus enunciados. Por ello, en este artículo se proponen estructuras para expresar objetivos y problemas de manera que se facilite su análisis y se puedan establecer relaciones semánticas y de consistencia entre ellos, empleando lógica de predicados, ya que este mecanismo permite una traducción directa desde lenguaje natural hacia una representación formal de frases para constatar la veracidad o falsedad del enunciado.O mundo organizacional sempre terá objetivos que atingir e se encontrará no caminho obstáculos que dificultam sua consecução. O primeiro passo para resolver problemas e estabelecer objetivos é identificá-los e representá-los, o qual quase sempre se faz por meio da linguagem natural, evidenciando a carência de métodos formais para a proposta de seus enunciados. Por isso, neste artigo propõem-se estruturas para expressar objetivos e problemas, de maneira que se facilite sua análise e possam ser estabelecidos relacionamentos semânticos e de consistência entre eles, empregando lógica de predicados, já que este mecanismo permite uma tradução direta desde linguagem natural para uma representação formal de frases para constatar a veracidade ou falsidade do enunciado.Organizational world will always have goals to reach and obstacles to fight, in order to reach those goals. Identifying and representing goals and problems are previous stages in solving problems and establishing goals. These tasks are commonly made in natural language, and no formal methods are used on them. For this reason, in this paper we propose first-order-predicate-logic structures for

  20. Réaction du polyisobutène chloré sur l'anhydride maléique : mécanisme. Catalyse par l'anhydride dichloromaléique Reaction of Chlorinated Polyisobutene on Maleic Anhydride. Mechanism. Catalysis by Dichloromaleic Anhydride

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    Sillion B.

    2006-11-01

    Full Text Available Dans cet article le mécanisme de la réaction de condensation du polyisobutène chloré sur l'anhydride maléique, qui sert dans la synthèse d'additif pour lubrifiant, est étudié par une cinétique globale et par un travail sur composés modèles. Il est montré que, dans cette réaction, l'anhydride maléique joue un double rôle : de catalyseur de déshydrochloration par une réactivité de type acide de Lewis organique, de réactif comme diénophile. Grâce à ces résultats, il est proposé une catalyse par l'anhydride dichloromaléique, qui permet une amélioration sensible du procédé. This article examines the mechanism of the chlorinated-polyisobutene condensation reaction on maleic anhydride. The overall kinetics and model compounds are investigated for this reaction which is used in the synthesis of lubricant additives. Maleic anhydride is shown to play the dual role of a dehydrochlorination catalyst by having a reactivity of the organic Lewis acid type and of a reactant like dienophile. These results are used to propose a catalysis by dichloromaleic anhydride which appreciably improves the process.

  1. Doença de alzheimer e demandas de cuidados: o que os enfermeiros sabem? Mal de Alzheimer y demandas de cuidados: ¿Cuánto saben los enfermeros? Alzheimer diseases and care demands: what do nurses know?

    Directory of Open Access Journals (Sweden)

    Silvana Poltroniere

    2011-06-01

    Full Text Available O objetivo deste estudo foi desvelar o conhecimento de enfermeiros de unidades de internação clínica acerca da Doença de Alzheimer (DA e da demanda de cuidados de pacientes e familiares. Estudo descritivo-exploratório, com abordagem qualitativa. Os dados foram obtidos através de entrevista semi-estruturada. A saturação dos dados ocorreu com 11 enfermeiros de dois hospitais privados. Da análise de conteúdo, emergiram seis categorias: caracterização da DA, fatores de risco, formas de diagnóstico, complicações, medicações para tratamento, cuidados com doente e família. Observou-se que os enfermeiros possuem um conhecimento limitado sobre a DA, focando as ações de cuidado na alteração clínica que motivou a internação hospitalar. Reconhecem sinais e sintomas, mas se mostram como figuras coadjuvantes na assistência, quando deveriam posicionar-se de forma mais autônoma frente ao cuidado e à atenção à família.El objetivo de este estudio fue revelar el conocimiento de enfermeros de unidades de internación clínica sobre la Enfermedad o Mal de Alzheimer (EA y las exigencias del cuidado de los pacientes y sus familias. Estudio descriptivo exploratorio, con abordaje cualitativo. Los datos fueron obtenidos a través de entrevista semiestructurada. La saturación de datos se realizó con once enfermeros de dos hospitales privados. Del análisis de contenido, emergieron seis categorías: caracterización de la EA, factores de riesgo, formas de diagnóstico, complicaciones, medicación para tratamiento, cuidados con el enfermo y la familia. Se observó que los enfermeros poseen un conocimiento parcial sobre la EA, enfocando las acciones de cuidado en la alteración clínica que causó la internación hospitalaria. Reconocen señales y síntomas, pero se muestran figuras coadyuvantes en la asistencia, cuando deberían posicionarse de forma más autónoma frente al cuidado y a la atención a la familia.The aim of the present study

  2. Posição viciosa de cabeça por astigmatismo mal corrigido: relato de caso Abnormal head position caused by incorrect prescription for astigmatism: case report

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    Flávia Augusta Attié de Castro

    2005-10-01

    Full Text Available A posição viciosa de cabeça é uma condição compensatória que visa proporcionar aos pacientes melhor rendimento visual. Pode ser causada por problemas oftalmológicos, como distúrbios oculomotores (nistagmos, estrabismos e altos astigmatismos. No entanto, compromete a estética e, a longo prazo, pode causar transtornos ortopédicos (coluna cervical e assimetrias faciais. Relatamos o caso de uma garota, JL, 8 anos, com cabeça inclinada para esquerda havia vários anos. Fazia uso de óculos prescritos em outro serviço para correção de astigmatismo misto: OD= +2,00 DE Ç -5,50 DC a 180º e OE= +2,25 DE Ç -5,75 DC a 180º. No exame oftálmico, a paciente apresentava cabeça inclinada para a esquerda e acuidade visual com correção de 0,5 no OD e 0,7 OE. Os testes de cobertura simples e alternado não evidenciaram desvio ocular. Rotações oculares, biomicroscopia e fundoscopia também não mostraram alterações. Na refratometria sob cicloplegia e teste de lentes foram encontrados: OD= +3,50 DE Ç -6,00 DC a 10º e OE= +3,50 DE Ç -6,00 DC a 170º, com acuidade visual igual a 1,0 nos olhos direito e esquerdo. Foram prescritas as lentes encontradas no exame e a paciente retornou com a correção nova sem a inclinação de cabeça. Erros refracionais mal corrigidos também podem gerar torcicolo e, muitas vezes, passam despercebidos. Refratometria sob cicloplegia e teste de lentes são fundamentais para um diagnóstico preciso.Abnormal head position is a compensatory condition which improves patients' vision. It can be caused by ophthalmological problems such as oculomotor imbalances (strabismus, nystagmus and high astigmatisms. However, it results in esthetic impairment, orthopedic trouble and facial asymmetries. We describe a case of a girl, JL, 8 years, with abnormal head position tilted to the left since the last glasses were prescribed. The correction used by the patient was: right eye = +2.00 sph à -5.5 cyl 180° and left eye = +2

  3. Salivary gland proteins of the human malaria vector, Anopheles dirus B (Diptera: Culicidae Proteínas das glândulas salivares do Anopheles dirus B (Diptera: Culicidae, vetor da malária humana

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    Narissara Jariyapan

    2007-02-01

    Full Text Available Salivary gland proteins of the human malaria vector, Anopheles dirus B were determined and analyzed. The amount of salivary gland proteins in mosquitoes aged between 3 - 10 days was approximately 1.08 ± 0.04 µg/female and 0.1 ± 0.05 µg/male. The salivary glands of both sexes displayed the same morphological organization as that of other anopheline mosquitoes. In females, apyrase accumulated in the distal regions, whereas alpha-glucosidase was found in the proximal region of the lateral lobes. This differential distribution of the analyzed enzymes reflects specialization of different regions for sugar and blood feeding. SDS-PAGE analysis revealed that at least seven major proteins were found in the female salivary glands, of which each morphological region contained different major proteins. Similar electrophoretic protein profiles were detected comparing unfed and blood-fed mosquitoes, suggesting that there is no specific protein induced by blood. Two-dimensional polyacrylamide gel analysis showed the most abundant salivary gland protein, with a molecular mass of approximately 35 kilodaltons and an isoelectric point of approximately 4.0. These results provide basic information that would lead to further study on the role of salivary proteins of An. dirus B in disease transmission and hematophagy.Proteínas das glândulas salivares do Anopheles dirus B (Diptera: Culicidae, vetor da malária humana foram determinadas e analisadas. A quantidade de proteínas das glândulas salivares em mosquitos com três a 10 dias de idade foi de aproximadamente 1,08 ± 0,04 µg/ fêmea e de 0,1 ± 0,05 µg/macho. As glândulas salivares de ambos os sexos mostraram organização morfológica semelhante à de outros mosquitos anofelinos. Em fêmeas, apirase acumula-se nas regiões distais, enquanto alfa-glucosidase foi encontrada na região proximal dos lóbulos laterais. Esta distribuição diferencial das enzimas analisadas reflete a especialização de

  4. EL MALESTAR EN LA RELACIÓN MÉDICO- PACIENTE O MAL ESTAR NA RELAÇÃO MÉDICO-PACIENTE UNEASINESS IN THE PHYSICIAN-PATIENT RELATIONSHIP

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    Gabriela Manitta

    2005-01-01

    Full Text Available Lo que se plantea en torno al malestar en la relación médico- paciente es la posibilidad de reconocer la locura que engendran algunas normas, tales como aquella que pretende transformar la acción médica en una operación de autómata. El médico puede asumir una posición diferente si está dispuesto a preservar en sí el lugar de su propia ignorancia acerca de la particularidad inalienable de cada enfermo, de esa historia individual en la que anida el síntoma. Pues aun cuando se esté en condiciones de afirmar que se han respetado los derechos del paciente, nada se sabe de él. Es necesario que el médico pueda situarse frente al sujeto como frente a un misterio para poder reconocer la particularidad de éste y para que el paciente pueda reconocerse en su particularidadO que se coloca em torno do mal estar na relação médico-pacinte é a possibilidde de reconhecer a loucura provocada por algumas normas, tais como aquela que pretende transformar a ação médico numa operação autômata. O médico pode assumir uma posição diferente se está disposto a preservar em si, o lugar de sua própria ignorância em relação à singularidade inalienável de cada doente, de sua história individual que se localiza no sintoma. Mesmo quando se está em condições de afirmar que os direitos do paciente foram respeitados, nada se sabe dele. É necessário que o médico se situe frente ao sujeito, estando frente a um mistério para poder reconhecer a singularidade deste, e para que o paciente também possa reconhecer-se em sua singularidadeThe possibility to recognize the madness that certain norms generate, such as the one that pretends to transform the medical action into an automaton's operation is stated around the uneasiness in the physician-patient relationship. Physicians may assume a different position if they are willing to keep in themselves the sight of their own ignorance about the inalienable particularity of each sick person, and of

  5. Cistatina C como predictor de síndrome cardio-renal y mal pronóstico en pacientes internados por insuficiencia cardíaca aguda y función renal normal

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    Iván Constantin

    2016-01-01

    Full Text Available Introducción: El desarrollo de disfunción renal en el contexto de una falla cardíaca aguda se conoce como síndrome cardiorrenal (SCR tipo 1. El empeoramiento de la función renal (EFR durante la internación es un predictor de mal pronóstico. La cistatina C ha surgido como un marcador de función renal alternativo a la creatinina. Objetivo: Demostrar la utilidad clínica de la cistatina C como predictor de EFR y factor pronóstico en pacientes con insuficiencia cardíaca aguda y sin disfunción renal evaluada por creatinina al ingreso. Material y métodos: Se llevó a cabo un estudio observacional, prospectivo, de pacientes consecutivos con diagnóstico de insuficiencia cardíaca aguda y sin disfunción renal, definida como un valor de creatinina < 1,3 mg/dl al ingreso. Se realizó un dosaje de cistatina C al ingreso. El punto final primario fue EFR y los secundarios fueron mortalidad hospitalaria, mortalidad total y reinternación por insuficiencia cardíaca. Resultados: Se incluyeron 166 pacientes con una mediana de edad de 85 años (IIC 77,7-89. La incidencia de EFR fue del 29,7%, con una mortalidad hospitalaria del 3,1% y una mortalidad total del 24,4%. La mediana de seguimiento fue de 193 días. El valor de cistatina C fue significativamente mayor en los pacientes que desarrollaron EFR (1,72 ± 0,58 mg/dl vs. 1,51 ± 0,41 mg/dl; p = 0,03 y en los pacientes que murieron en el seguimiento (1,76 ± 0,49 mg/dl vs. 1,51 ± 0,46 mg/dl; p = 0,004. La cistatina C resultó un predictor independiente de mortalidad (OR 3,03, IC 95% 1,22-7,47 y de EFR (OR 2,38, IC 95% 1,02- 5,5 en el análisis multivariado. Se halló un punto de corte óptimo de 1,6 mg/dl de cistatina, con una sensibilidad del 61,22% y una especificidad del 60,34% para el desarrollo de EFR y del 61,54% y 61,98%, respectivamente, para mortalidad total. Conclusión: El valor de cistatina C al ingreso es predictor de desarrollo de EFR durante la internación y de mayor mortalidad en

  6. Factores que determinan el mal pronóstico y la exacerbación del asma en niños que asisten a consulta de alergología pediátrica Factors determining the poor prognosis and asthma exacerbation in children seen in the pediatric allergy service

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    Alain R. Rodríguez-Orozco

    2007-03-01

    Full Text Available El asma es una de las enfermedades de mayor impacto en la práctica pediátrica. Este es un estudio descriptivo, transversal que se realizó con el objetivo de identificar los factores que determinan la exacerbación y el mal pronóstico del asma bronquial en los niños. Se estudiaron 45 pacientes con diagnóstico de asma bronquial. Las crisis se presentaron en el hogar en el 76 % y en el 24 %, en la escuela. Los desencadenantes de las crisis agudas de asma bronquial fueron: el ejercicio (73 %, las infecciones respiratorias (57 % y la rinitis (55 %. Los factores de mal pronóstico más frecuentemente encontrados fueron: rinorrea sin catarro (60 %, sexo masculino (51 %, 3 o más episodios de sibilancias en los 6 meses previos (42 % y asma en los padres (37 %. La presencia de las exacerbaciones y los criterios de mal pronóstico repercuten en el control y en la calidad de vida del niño asmático y deben detectarse en la consulta de atención primaria.Asthma is one of the diseases with a greater impact on pediatric practice. This descriptive, cross-sectional study was undertaken to identify those factors determining the exacerbation and poor prognosis of bronchial asthma in children. Forty five patients with diagnosis of bronchial asthma were studied. The crises were developed at home in 76 % and at school in 24 % of the children. Triggering causes of acute crises of bronchial asthma were: exercise (73 %, respiratory infections (57 %, and rhinitis (55 %. The factors of poor prognosis most frequently found were: rhinorrhea without cold (60 %, male sex (51%, three or more episodes of wheezes in previous months (42 %, and asthma in parents (37 %. The presence of exacerbations and the criteria of poor prognosis influence on the control and quality of life of the asthmatic children, and they should be detected at the primary care level.

  7. Controle da transmissão da malária em área de garimpo no Estado do Amapá com participação da iniciativa privada Control of malaria transmission in a gold-mining area in Amapá State, Brazil, with participation by private enterprise

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    Álvaro Augusto Couto

    2001-08-01

    Full Text Available Reportamos no presente trabalho a caracterização epidemiológica da malária, seguida da implantação de um programa de controle da endemia em uma área de garimpo, localizada ao norte do estado do Amapá. Considera-se a influência desta região no número total de casos do estado e o impacto da doença na população representada pelos funcionários e empreiteiros da Mineração Novo Astro S/A, bem como pela comunidade da Vila de Lourenço, Município de Calçoene, Amapá e garimpos adjacentes. O impacto das ações de controle adotadas no âmbito do programa, caracterizam-se pela significativa redução da incidência da malária na área e a redução da morbi-mortalidade. Ressalta-se a importância da participação da iniciativa privada, principalmente aquelas que desenvolvem projetos de grande porte na região Amazônica brasileira, no controle das endemias prevalentes na região, particularmente a malária.This paper reports on the epidemiological characterization of malaria following implementation of a program to control the endemic in a gold-mining area in northern Amapá State. The study focuses on total malaria cases in Amapá and the impact of the disease on the population, as represented by the Mineração Novo Astro S/A company and its employees as well as the community of Vila de Lourenço in the municipality of Calçoene, and adjacent gold miners. The effect of control measures in the program area is indicated by a significant reduction in malaria incidence and malaria-related morbidity and mortality. The importance of participation by private enterprise is emphasized, particularly in large projects for the control of endemic diseases (notably malaria in the Amazon Region.

  8. Retrospective study of malaria prevalence and Anopheles genus in the area of influence of the binational Itaipu reservoir Estudo retrospectivo da prevalência de malária e do gênero Anopheles na área de influência do reservatório de Itaipu Binacional

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    Ana Lucia Falavigna-Guilherme

    2005-04-01

    Full Text Available The importance of hydroelectric dams beside the human interchange in the maintenance of malarious foci and the occurrence of the Anopheles genus on the Binational Itaipu Reservoir were the main points of this retrospective study. Data were collected from existing registrations at National, State and Municipal Health Departments and literature systematic overview, from January 1984 to December 2003. The occurrence of some outbreak of malaria, mainly by Plasmodium vivax, and the prevalence of species of the Anopheles genus different from Anopheles darlingi in the region are discussed. The malaria in the left bank of Paraná River is a focal problem, which must be approached locally through health, educational and social actions to prevent the continuity of outbreaks in the area. Concomitantly, it is necessary to plan and apply effective surveillance measures in the influence area of the Itaipu Reservoir.A importância de reservatórios de hidroelétricas e do intercâmbio humano na manutenção de focos de malária e a ocorrência do gênero Anopheles no reservatório de Itaipu Binacional foram os pontos destacados neste estudo retrospectivo. Os dados foram coletados de registros existentes em órgãos municipais, estadual e nacional de saúde e por revisão sistemática da literatura, no período de janeiro de 1984 a dezembro de 2003. A ocorrência de alguns surtos de malária, principalmente por Plasmodium vivax, e a prevalência de espécies do gênero Anopheles diferentes de Anopheles darlingi na região foram discutidos. A malária na margem esquerda do rio Paraná é um problema focal que deve ser abordado localmente através de medidas voltadas à saúde, educação e área social que previnam a continuidade da ocorrência de surtos na área. Concomitantemente, é necessário planejar e aplicar medidas efetivas de vigilância epidemiológica na área de influência do reservatório de Itaipu.

  9. Diagnóstico tardio de malária em área endêmica de dengue na extra-Amazônia Brasileira: experiência recente de uma unidade sentinela no estado do Rio de Janeiro Delayed diagnosis of malaria in a dengue endemic area in the Brazilian extra-Amazon: recent experience of a malaria surveillance unit in state of Rio de Janeiro

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    Anielle de Pina Costa

    2010-10-01

    Full Text Available INTRODUÇÃO: A letalidade da malária na região extra-amazônica é cerca de 80 vezes maior do que na Amazônia, que concentra 99,8% dos casos do país. Em áreas de transmissão de dengue, como o Rio de Janeiro, o atraso no diagnóstico e tratamento da malária dos pacientes com febre, provenientes de áreas endêmicas de malária, pode ser, entre outros fatores, devido à confusão entre o diagnóstico das duas doenças pelos generalistas da rede de assistência médica. Neste trabalho, apresentamos as consequências do atraso diagnóstico em três pacientes com malária por Plasmodium falciparum; P. malariae e P. vivax, que, após o périplo habitual para tratamento de dengue, procuraram a nossa instituição onde foram corretamente diagnosticados e submetidos aos tratamentos adequados. MÉTODOS: Descrição de três casos de malária diagnosticada tardiamente e encaminhados ao IPEC/ FIOCRUZ, entre os anos de 2007 e 2008. RESULTADOS: uma brasileira proveniente de Moçambique, primo-infectada por P. falciparum, com malária diagnosticada após 6 dias do início da febre, morreu com malária cerebral e choque. Outro paciente com malária por P. malariae teve um curso grave e prolongado, mas ficou curado após o tratamento específico. A terceira paciente diagnosticada tardiamente apresentou malária por P. vivax adquirida na região de Mata Atlântica no Estado do Rio. CONCLUSÕES: Os profissionais de saúde do Rio devem ser treinados para aperfeiçoar a vigilância e o tratamento oportuno da malária e evitar desfechos mórbidos e fatais. Sugere-se que uma investigação de focos de malária autóctone em áreas de mata no estado seja realizada.INTRODUCTION: The mortality of malaria in the extra-Amazon region is about 80 times higher than in the Amazon region, where malaria is concentrated (99.8% of cases. In areas of dengue transmission, delay in the diagnosis and treatment of malaria in patients with fever who reside in areas of malaria

  10. Efficacy of sulfadoxine-pyrimethamine and mefloquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Amazon basin of Peru Eficácia da sulfadoxina-pirimetamina e mefloquina no tratamento de malária não-complicada por Plasmodium falciparum na bacia amazônica peruana

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    Alan J. Magill

    2004-06-01

    Full Text Available In vivo antimalarial drug efficacy studies of uncomplicated Plasmodium falciparum malaria at an isolated site in the Amazon basin of Peru bordering Brazil and Colombia showed >50% RII/RIII resistance to sulfadoxine-pyrimethamine but no evidence of resistance to mefloquine.Testes in vivo foram realizados para avaliar resistência a drogas antimalária, em pessoas com malária não complicada, causada por Plasmodium falciparum, numa região isolada da Bacia Amazônica, na fronteira com o Brasil e a Colômbia. Os testes mostraram resistência >50% RII/RIII a sulfadoxina-pirimetamina, mas não evidenciaram resistência a mefloquina.

  11. A utilização de uma rede neural artificial para previsão da incidência da malária no município de Cantá, estado de Roraima Use of an artificial neural network to predict the incidence of malaria in the city of Cantá, state of Roraima

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    Guilherme Bernardino da Cunha

    2010-10-01

    Full Text Available INTRODUÇÃO: A malária é uma doença endêmica na Amazônia Legal Brasileira, apresentando riscos diferentes para cada região. O Município de Cantá, no Estado de Roraima, apresentou para todo o período estudado, um dos maiores índices parasitários anuais do Brasil, com valor sempre maior que 50. O presente estudo visa à utilização de uma rede neural artificial para previsão da incidência da malária nesse município, a fim de auxiliar os coordenadores de saúde no planejamento e gestão dos recursos. MÉTODOS: Os dados foram coletados no site do Ministério da Saúde, SIVEP - Malária entre 2003 e 2009. Estruturou-se uma rede neural artificial com três neurônios na camada de entrada, duas camadas intermediárias e uma camada de saída com um neurônio. A função de ativação foi à sigmoide. No treinamento, utilizou-se o método backpropagation, com taxa de aprendizado de 0,05 e momentum 0,01. O critério de parada foi atingir 20.000 ciclos ou uma meta de 0,001. Os dados de 2003 a 2008 foram utilizados para treinamento e validação. Comparam-se os resultados com os de um modelo de regressão logística. RESULTADOS: Os resultados para todos os períodos previstos mostraram-se que as redes neurais artificiais obtiveram um menor erro quadrático médio e erro absoluto quando comparado com o modelo de regressão para o ano de 2009. CONCLUSÕES: A rede neural artificial se mostrou adequada para um sistema de previsão de malária no município estudado, determinando com pequenos erros absolutos os valores preditivos, quando comparados ao modelo de regressão logística e aos valores reais.INTRODUCTION: Malaria is endemic in the Brazilian Amazon region, with different risks for each region. The City of Cantá, State of Roraima, presented one of the largest annual parasite indices in Brazil for the entire study period, with a value always greater than 50. The present study aimed to use an artificial neural network to predict the

  12. Biologia de anofelinos amazônicos: XII. Ocorrência de espécies de Anopheles, dinâmica da transmissão e controle da malária na zona urbana de Ariquemes (Rondônia)

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    Tadei, Wanderli Pedro; Santos, Joselita Maria Mendes dos; Costa, Wellington Luciano de Souza; Scarpassa, Vera Margarete

    1988-01-01

    Dados sobre o grau de incidência e distribuição de espécies Anopheles, em Ariquemes (RO), evidenciaram que a diversidade é maior na periferia da cidade e que Anopheles darlingi é registrada em praticamente todas as localidades de coleta. O inquérito entomológico revelou níveis diferentes de penetração da espécie na área urbana, podendo-se constatar que os Setores 1 e 3 são áreas livres de malária; Setores 2 e 4 mostram riscos na periferia; e a Área Industrial e Setor de Áreas Especiais, Conju...

  13. Caracterização das epidemias de malária nos municípios da Amazônia Brasileira em 2010 Caracterización de las epidemias de malaria en los municipios de la Amazonia brasileña en 2010 Characteristics of malaria epidemics in the municipalities of the Brazilian Amazon, 2010

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    Pedro Luiz Tauil

    2013-05-01

    Full Text Available Epidemias de malária ocorrem anualmente nos municípios da Região Amazônica, Brasil, no entanto os serviços de saúde não adotam, de maneira sistemática, instrumentos para detecção e contenção oportunas desses eventos. O objetivo foi caracterizar as epidemias de malária na região segundo duração, espécie de Plasmodium e vulnerabilidade das populações. Foi avaliado um sistema de monitoramento automatizado da incidência da malária, com base no diagrama de controle segundo quartis, para identificar as epidemias da doença. Em 2010, ocorreram epidemias em 338 (41,9% municípios da região. Houve epidemias por P. falciparum e por P. vivax, separadamente, e também por ambas as espécies. Epidemias com duração de um a quatro meses ocorreram em 58,3% dos municípios epidêmicos; de cinco a oito meses, em 24,3%; e de nove a 12 meses, em 17,4%. O monitoramento automatizado da variação da incidência da malária poderá contribuir para detecção precoce das epidemias e melhorar o seu controle oportuno.Las epidemias de malaria ocurren anualmente en los municipios de la Región Amazónica, Brasil, no obstante, los servicios de salud no adoptan de manera sistemática instrumentos para la detección y contención oportuna de este tipo de eventos. El objetivo fue caracterizar las epidemias de malaria en la región según su duración, especie de Plasmodium y vulnerabilidad de las poblaciones. Se evalúo un sistema de supervisión automatizado de la incidencia de la malaria, en base al diagrama de control según cuartiles, con el fin de identificar las epidemias de la enfermedad. En 2010, se produjeron epidemias en 338 (41,9% municipios de la región. Hubo epidemias por P. falciparum y por P. vivax, separadamente, y también por ambas especies. Hubo epidemias con una duración de uno a cuatro meses que se produjeron en un 58,3% de los municipios epidémicos; de cinco a ocho meses, en un 24,3%; y de nueve a 12 meses, en un 17,4%. La

  14. Malaria epidemics in Europe after the First World War: the early stages of an international approach to the control of the disease Malária epidêmica na Europa após a Primeira Guerra Mundial: estágios iniciais de uma abordagem internacional de controle da doença

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    Gabriel Gachelin

    2011-06-01

    Full Text Available The severity and endemicity of malaria declined gradually in Europe until WWI. During and after the war, the number of malaria cases increased substantially and peaked in 1922-1924. This prompted the Hygiene Commission of the League of Nations to establish a Malaria Commission in 1923 to define the most efficient anti-malaria procedures. Additionally, between 1924 and 1930 there were several international meetings and collaborations concerning malaria, which involved the main institutes of parasitology and the Rockefeller Foundation. The Commission reports, the guidelines for anti-malaria campaigns and the scientific programs which came out of these meetings and collaborations are analyzed in the present paper.Antes da Segunda Guerra Mundial, a severidade e endemicidade da malária diminuíram gradualmente na Europa. Durante e após a guerra, o número de casos cresceu substancialmente, chegando ao máximo entre 1922 e 1924. Isso fez com que a Comissão de Higiene da Liga das Nações estabelecesse, em 1923, a Comissão de Malária, para definir procedimentos mais eficazes contra a doença. Entre 1924 e 1930 encontros e colaborações internacionais, nos quais estiveram envolvidos os principais intitutos de parasitologia e a Fundação Rockefeller, discutiram a enfermidade. Os relatórios da Comissão, as diretrizes para campanhas antimaláricas e os programas científicos decorrentes desses encontros e colaborações são analisados no artigo.

  15. THE SAFETY MEASURE OF PROHIBITING TO EXERCISE A PROFESSION, IMPOSED BY THE COURT IN CASE OF MAL PRAXIS, MAY ENVISAGE THE PROFESSION OF DOCTOR IN THE WIDER SENSE (AS A WHOLE OR ONLY THE SPECIALTY THAT OCCASIONED THE COMMITTING OF THE OFFENCE PROVIDED IN THE CRIMINAL LAW

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    Traian DIMA

    2018-05-01

    Full Text Available The present paper examines the possibility for the courts of law to order, in case of medical malpractice, the safety measure of prohibiting to exercise the profession of doctor in the wider sense, or only the specialty that occasioned the committing of the offence provided in the criminal law, analyzing the judicial practice regarding this issue. In accordance with Article 450 paragraph (2 of Law no. 95/2006, “disciplinary liability of doctors does not exclude criminal, tort or civil liability”. Between the regulation contained in Article 450 paragraph (2 of Law no. 95/2006 and the safety measure of prohibiting to exercise the profession of doctor, as criminal penalty, there is a close connection, within the meaning that the special law, in particular Law no. 95/2006 derogates from the general criminal law, in particular Article 111 of the Criminal Code in connection with the prohibition of exercising the medical profession. The disciplinary penalties that may be imposed against doctors for mal praxis are listed in Article 455 of Law no. 95/2006. Article 455 letter (e sets out, as disciplinary penalty which may be imposed against doctors “the prohibition to exercise the profession or certain medical activities” for a period ranging between one month and one year. Comparing the provisions of Article 455 letter (e of Law no. 95/2006 with the provisions of Article 111 of the Criminal Code, it may be noticed that the scope of disciplinary accountability of the doctor having committed the civil mal praxis is more comprehensive than the scope of the safety measure imposed by the criminal court.

  16. Le Mal africain – pas si mal que ça !

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    Mike Singleton

    2011-02-01

    Full Text Available De l’avis engagé d’une génération précédente d’observateurs occidentaux, aussi bien leurs propres couches populaires que la plupart des peuples primitifs se sont laissé faire par le rouleau compresseur de la Modernité. En Angleterre, où un surplus de fumier chevalin avait “libéré” pour le marché de l’emploi une main-d’œuvre paysanne aussi dépaysée que pléthorique (Wrigley, 1988, les Luddites (Thompson, 1968, dignes descendants d’autres défenseurs des causes perdues du Royaume comme les «Dig...

  17. Territorial hypothesis predicts the trade-off between reproductive opportunities and parental care in three species of damselfishes (Pomacentridae: Actinopterygii La hipótesis territorial predice la compensación entre las oportunidades reproductivas y el cuidado parental en tres especies de peces damisela (Pomacentridae: Actinopterygii

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    Eduardo Bessa

    2012-03-01

    Full Text Available Paternal care is rare in most animals, but common in fishes, including Pomacentridae. One way of explaining it is through the territorial hypothesis, which predicts that paternal care may evolve when caring for a territory with eggs will not cost more than territories without eggs. Here we describe the reproductive behavior of three pomacentrids from São Paulo, Brazil, and evaluate if the territorial hypothesis explains their behavioral variation through five predictions. We checked if females have multiple spawns (prediction 1, if they forage more (prediction 2 and if territory defence demands more when eggs are present (prediction 3. We also described how visible eggs are (prediction 4 and how available nesting sites are (prediction 5. Chromis multilineata differed from Abudefduf saxatilis and Stegastes fuscus by not guarding the eggs, spending less time with territoriality and fanning eggs; and more time feeding and foraging. Females of the three species are iteroparous. Females' A. saxatilis and S. fuscus foraged more than males, which spent the same amount of time in territorial defence before and after eggs were delivered. These two species also have very conspicuous egg clutches on clean rock surfaces defended by them. On the other hand, males and females of C. multilineata spent the same time foraging, while territoriality took more effort after eggs were present and it spawns cryptic eggs amid Sargassum, a common and disperse micro-environment in São Paulo rocky shores. Territorial hypothesis explains why paternal care by A. saxatilis and S. fuscus lasts longer than by C. multilineata.El cuidado paterno es raro en la mayoría de los animales, pero común en los peces, incluyendo los Pomacentridae. Una forma de explicar este fenómeno es la hipótesis territorial, que predice que el cuidado paterno puede evolucionar cuando la protección de un territorio con huevos no cuesta más que la de territorios sin huevos. Aquí se describe el

  18. Malária e aspectos hematológicos em moradores da área de influência dos futuros reservatórios das hidrelétricas de Santo Antônio e Jirau, Rondônia, Brasil Malaria and hematological aspects among residents to be impacted by reservoirs for the Santo Antônio and Jirau Hydroelectric Power Stations, Rondônia State, Brazil

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    Tony Hiroshi Katsuragawa

    2009-07-01

    Full Text Available Em Rondônia, prevê-se a construção de mais duas usinas hidrelétricas (UHE no rio Madeira, a montante da cidade de Porto Velho, Rondônia, Brasil (de Santo Antônio e Jirau. O objetivo deste trabalho foi analisar a prevalência da malária antes do início da implantação das obras civis e fazer considerações sobre os impactos da doença com o ingresso de milhares de trabalhadores e agregados atraídos pelas oportunidades de emprego e comércio. Os resultados obtidos mostram que a malária se faz presente em toda região, em variados graus de prevalência. Além disso, a existência de potenciais portadores assintomáticos de malária entre a população nativa pode ter relevância epidemiológica e deve ser considerada nos programas de controle da malária, vinda tanto das autoridades públicas quanto das empresas responsáveis pela instalação das UHE, visando o diagnóstico e tratamento precoce, controle vetorial, abastecimento de água e aplicação de infra-estrutura nos centros urbanos.In Rondônia State, Brazil, two new hydroelectric plants, Santo Antônio and Jirau, are scheduled for construction on the Madeira River, upriver from the State capital, Porto Velho. The current study analyzes malaria prevalence before the construction and provides information on the possible impacts of malaria burden related to the influx of thousands of persons attracted by direct and indirect employment opportunities. According to the findings, malaria is present throughout the region, with varying prevalence rates. The existence of potential asymptomatic malaria carriers among the local population may be epidemiologically relevant and should be considered in the malaria control programs organized by public authorities and companies responsible for building the power plants, aimed at early diagnosis and treatment, vector control, water supply, and infrastructure in the urban areas.

  19. Primary health care in municipalities at high risk for malaria Atención primaria a la salud en municipios de alto riesgo para malaria Atenção primária à saúde em municípios de alto risco para malária

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    Ana Cristina Soares Ferreira

    2011-12-01

    Programa Nacional de Control de Malaria y la Atención Básica de un modo general.Neste estudo pretendeu-se caracterizar aspectos da Atenção Básica, na região da Amazônia Legal, principal área endêmica para malária, no Brasil. O Ministério da Saúde recomenda a expansão da Atenção Básica nas áreas malarígenas. Foi realizado inquérito transversal, aplicado aos portadores de malária, em 6 municípios, durante os meses de janeiro e fevereiro de 2007. Os dados coletados foram tabulados e analisados, utilizando-se técnicas quantitativas. Registros de campo auxiliaram na composição das impressões do contexto dessas políticas nos locais pesquisados. A qualidade do acesso a consultas e medicamentos, o vínculo com os profissionais e com as Unidades Básicas de Saúde, o sistema de referência e contrarreferência, e a abordagem familiar e comunitária da saúde pelos profissionais, nos municípios do estudo, ainda são deficientes nesse nível de atenção. Há baixa integração entre o Programa Nacional de Controle de Malária e a Atenção Básica, de modo geral.

  20. Mal posición de tornillos pediculares lumbares que producen radiculalgia mecánica postoperatoria con estimulación neurofisiológica intraoperatoria normal: el valor de la estimulación neurofisiológica del trayecto del tornillo

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    Vicente García González

    2013-12-01

    Full Text Available OBJETIVO: Valorar una exploración neurofisiológica que identifique estos casos intraoperatoriamente y evite la mal posición de tornillos pediculares. MÉTODOS: En 293 pacientes intervenidos de escoliosis por vía posterior con tornillos pediculares y técnica "free hand", se implantaron 6.739 tornillos. De estos, ocho pacientes (2,7%, con edad promedio de 24 años, presentaron dolor radicular lumbar postoperatorio. En la TC postoperatoria se encontraron 10 tornillos lumbares (2L1-3L2-4L3-1L4 con prominencia mínima en la parte inferior del pedículo. Se evaluaron los umbrales de EMG del tornillo y del trayecto. RESULTADOS: En cirugía inicial no se detectaron anomalías en la palpación del trayecto, ni en el control radioscópico, ni alteraciones neurofisiológicas en la estimulación neurofisiológica con t-EMG. Todos presentaron dolor radicular en bipedestación y sedestación que remitía con reposo en cama. Los tornillos fueron retirados quirúrgicamente a los 37 días en promedio (R:4-182. En esta cirugía se repitió la monitorización neurofisiológica y volvió a mostrar valores normales (> 11mA. Tras la retirada de los tornillos, se realizó estimulación del trayecto que mostró en la parte media, umbrales por debajo de los valores normales (3,9-10,7mA. Tras un seguimiento promedio de 4,4 años (R:2,6-6.8, cinco pacientes referían tener molestias radiculares ocasionales y uno tenía déficit motor mínimo en la extremidad afectada. CONCLUSIONES: Se presenta un tipo de mal posicionamiento de tornillo pedicular lumbar que produce radiculalgia en bipedestación-sedestación y que no es detectado con monitorización convencional. La estimulación neurofisiológica del trayecto en la zona media, tras retirada del tornillo pedicular, produjo umbrales bajos de estimulación. Se recomienda estimulación sistemática del trayecto antes de la inserción del tornillo pedicular lumbar.

  1. Análise da freqüência de recaídas de malária por Plasmodium vivax em região não endêmica (São Paulo, Brasil Analysis of the frequency of relapses due to malaria caused by Plasmodium vivax in a non endemie area (São Paulo, Brazil

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    Marcos Boulos

    1991-04-01

    Full Text Available Em virtude da existência de poucas informações, devidamente registradas, sobre freqüência e épocas de recaídas de malária por Plasmodium vivax, contraída no Brasil, foi analisada casuística observada em região não endêmica e constituída por pacientes corretamente tratados. O índice de recaídas documentadas em São Paulo, foi alto (24,5%, com desenvolvimento precoce na maioria das oportunidades, ou seja, em tempo inferior a três meses.Very few well-established information is available about the frequency and timeliness of relapses in cases of Plasmodium vivax malaria acquired in Brazil. So, we analysed a series of correctly treated patients observed out of endemic areas. The rate of relapses seen in São Paulo, which may represent that of the parasitosis in the whole country, was high, ranging from 7.5% to 24.5%, and early in most cases, i.e. appearing by three months, what anticipates a high endemicity.

  2. Relationship between plasma and red blood cell concentrations of quinine in Brazilian children with uncomplicated Plasmodium falciparummalaria on oral therapy Relação entre as concentrações plasmáticas e eritrocitárias de quinina em crianças com malária por Plasmodium falciparum não complicada em terapia via oral

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    José L.F. Vieira

    2009-04-01

    Full Text Available We determined the relationship between plasma and red blood cell concentrations of quinine in children with uncomplicated falciparum malaria from an endemic area of Amazonian region. Quinine was determined by high performance liquid chromatography with ultraviolet detection. In the steady state the ratio between plasma and red blood cell quinine concentration was 1.89 ± 1.25 ranging from 1.05 to 2.34. This result demonstrated that quinine do not concentrate in red blood cell of Brazilian children and characterize the absence of interracial difference in this relationship.Neste estudo foi determinada a relação entre as concentrações plasmáticas e eritrocitárias de quinina em crianças com malária falciparum não complicada, oriundas de área endêmica da Região Amazônica. A quinina foi detrminada por cromatografia líquida de alta eficiência. No estado de equilíbrio, a relação foi 1,89 ± 1,25 variando de 1,05 a 2,34. Estes resultados demonstraram que a quinina não se concentra nos eritrócitos das crianças e caracterizaram a ausência de diferença racial nesta relação.

  3. Mudanças no padrão epidemiológico da malária em área rural do médio Rio Negro, Amazônia brasileira: análise retrospectiva Changes in the epidemiological pattern of malaria in a rural area of the middle Rio Negro, Brazilian Amazon: a retrospective analysis

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    Martha Cecilia Suárez-Mutis

    2007-04-01

    Full Text Available Foi realizado um estudo retrospectivo dos casos de malária ocorridos entre 1992 e 2004 no Município de Barcelos, Amazonas, Brasil, aprofundando as informações existentes na área altamente endêmica do Rio Padauri, afluente do Rio Negro. Foram identificados 16.795 casos de malária, sendo 61,4% (10.318 da área rural e 38,6% (6.477 da área urbana, com uma incidência parasitária anual média de 136,7 por mil habitantes na área urbana e 613,6 na área rural. A incidência parasitária anual média no Rio Padauri foi de 708,9/1.000. Nesse rio, foram diferenciados dois períodos epidemiológicos, sendo um denominado epidêmico (1992-1998 e outro pós-epidêmico (1999-2004. Comparando os dois períodos, a proporção homem/mulher mudou de 1,8 para 1,14, a média de idade dos pacientes passou de 17,9 para 14,8, o percentual de casos por Plasmodium falciparum reduziu-se de 51,9% para 23,7, e o percentual de lâminas com baixa densidade parasitária de P. falciparum passou de 35,3% para 44,9%, e as de P. vivax de 24% para 35%. Todas essas diferenças foram estatisticamente significativas (p A retrospective study on reported malaria cases in the municipality (county of Barcelos, Amazonas State, Brazil, was performed from 1992 to 2004, emphasizing the high endemic area along the Padauiri, an affluent of the Rio Negro. 16,795 cases were reported, 10,318 (61.4% from the rural area and 6,477 (38.6% from the urban area. Mean annual parasite index for the period was 136.7 per 1,000 inhabitants in the urban area and 613.6 per 1,000 in the rural area of Barcelos and 708.9 per 1,000 in the Padauiri area. In the latter area, two periods were considered: one epidemic, from 1992 to 1998, and the other post-epidemic, from 1999 to 2004. Comparing the two periods, the male/female ratio changed from 1.8 to 1.14, mean patient age from 17.9 to 14.8, proportion of Plasmodium falciparum cases from 51.9% to 23.7%, proportion of slides with low P. falciparum parasite

  4. Conhecimentos, práticas e percepções de profissionais de saúde sobre o tratamento de malária não complicada em municípios de alto risco da Amazônia Legal Uncomplicated malaria treatment in the Brazilian Amazon: knowledge, practices and perceptions of health workers in high-incidence municipalities

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    Claudia Garcia Serpa Osorio-de-Castro

    2011-01-01

    Full Text Available O controle da malária no Brasil conta com diagnóstico precoce e tratamento adequado e oportuno como estratégia para cura rápida e duradoura. Consequências clínicas e resistência aos antimaláricos podem resultar de falhas na prescrição, dispensação e aceitação dos profissionais aos esquemas terapêuticos propostos. Objetivou-se avaliar conhecimentos, práticas, percepções e atitudes de profissionais envolvidos na assistência farmacêutica à malária, frente ao protocolo oficial e a possíveis falhas na terapêutica. Entrevistaram-se profissionais em seis municípios na Amazônia Legal. Utilizou-se técnica de análise do discurso para determinação de categorias analíticas e sistematização. Dos 63 entrevistados, houve apenas um médico. Os demais, de nível médio, atuavam no diagnóstico, indicação e dispensação do tratamento antimalárico. O tempo de formação e de treinamento foi variável. Houve falhas na adesão ao protocolo nacional, perpassando indicação, dispensação e orientação aos pacientes. Os profissionais carecem de conhecimento para lidar com as especificidades da doença e do tratamento. A responsabilização de profissionais que não possuem o preparo necessário para a atenção sugere necessidade de políticas para a adequada capacitação e incorporação de recursos humanos.Malaria control in Brazil is based on early diagnosis and adequate and timely treatment as strategies for a rapid and long-lasting cure. Clinical consequences and resistance to antimalarials may arise from problems in prescribing, dispensing and in acceptance of therapeutic regimens by healthcare workers. We studied knowledge and practices, perceptions and attitudes of health workers participating in pharmaceutical services for malaria, regarding the official protocol and the possible flaws in therapy. Health workers from six municipalities in the Brazilian Amazon were interviewed. Speech analysis was employed as a technique

  5. Aspectos da transmissão focal de malária na Ilha de São Luis, Maranhão Aspects of the focal transmission of malaria in the Island of São Luis, Maranhão

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    Antônio Rafael da Silva

    2006-06-01

    Full Text Available O estudo foi desenvolvido com o objetivo de caracterizar um foco de transmissão de malária em Guarapiranga, município de São José de Ribamar, MA. A unidade de estudo foi o grupo familiar, aplicando-se questionário sobre identificação, situação econômica, hábitos dos moradores e características dos domicílios. Foram visitadas 54 famílias, totalizando 207 habitantes, sendo 113 do sexo masculino e 95, do feminino. 95 pessoas tinham de 5 a 24 anos. Agricultura e pesca são a base da economia local, com 64,8% das famílias auferindo renda mensal menor que um salário mínimo. A maioria das casas é construída de taipa, coberta de palha, tem piso de chão batido e não tem instalações sanitárias. Em relação à entrada de mosquitos, 62,2% são parcialmente protegidas. A água para consumo provém de cacimbas ou poços rasos em 78,8%, e o lixo é deixado a céu aberto em 53,7% dos domicílios. Foram registrados 106 casos de malária por Plasmodium vivax. O provável transmissor foi o Anopheles (N aquasalis e o tratamento com cloroquina associado à primaquina teve bons resultados.The aim of the study was to typify a malaria focus in Guarapiranga, in the district of São José de Ribamar, MA. A questionnaire regarding identification, economic situation, habits of the residents and characteristic of the residences was applied to each family. Fifty four families were visited and 207 inhabitants were interviewed (113 men and 95 women; 95 individuals were aged between 5 and 24 years old. Agriculture and fishing are the basis of the local economy; 64.8% of the families earn less than one living wage. The majority of the residences are constructed of mud walls, straw roofs, a beaten earth floor, with no basic sanitation. 62.2% of the residences are partially protected against the entry of mosquitoes. Water for domestic use comes from natural waterholes in 78.8% of the residences. Rubbish is left in the open air in 53.7% of the residences

  6. Spatial analysis for stratification of priority malaria control areas, Mato Grosso State, Brazil Análise espacial na estratificação de áreas prioritárias para o controle da malária no Estado de Mato Grosso, Brasil

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    Marina Atanaka-Santos

    2007-05-01

    Full Text Available The goal of this study was to stratify priority areas for malaria control in the State of Mato Grosso, Brazil, based on spatial analysis. The variables used were: Annual Parasite Index (API, Plasmodium falciparum/Plasmodium vivax ratio, population variation, number of families settled, and percent of deforested area. The Moran's I and Local Moran Test were applied, visualized with the Box Map and Moran Map, for 1986- 1991, 1992-1997, and 1998-2003. Box Map identified areas with high, low, and intermediate priority for control, and Moran Map identified municipalities with significant autocorrelation. In the high priority area, located in the North of Mato Grosso, malaria incidence decreased drastically despite the increase in the number of municipalities from the first to the last period. Other municipalities were added to the lower priority area, from the Southeast, Southwest, and Central-South of the State. The intermediate priority area was located along the border with neighboring States and municipalities classified as high and low priority. Spatial analysis showed the importance of the neighboring phenomenon between municipalities in defining priority areas, thus highlighting the technique's advantages for use in malaria control and surveillance.Pautado em técnicas de análise espacial, analisou-se a estratificação de áreas prioritárias para controle da malária no Estado de Mato Grosso, Brasil. Trabalhou-se Incidência Parasitária Anual, relação Plasmodium falciparum/Plasmodium vivax, variação populacional, número de famílias assentadas e percentuais da área desmatada. Foram utilizados os testes de I de Moran e Moran Local, visualizadas pelo Box Map e Moran Map, nos períodos de: 1986 a 1991, 1992 a 1997 e 1998 a 2003. Pelo Box Map identificaram-se áreas de prioridade maior, menor e intermediária, e pelo Moran Map localizaram-se municípios com autocorrelação estatisticamente significante. Na área de maior prioridade

  7. Uso do sensoriamento remoto para estudar a influência de alterações ambientais na distribuição da malária na Amazônia brasileira Use of remote sensing to study the influence of environmental changes on malaria distribution in the Brazilian Amazon

    Directory of Open Access Journals (Sweden)

    Cíntia Honório Vasconcelos

    2006-03-01

    Full Text Available A construção da hidroelétrica de Tucuruí, no sudeste do Estado do Pará, Brasil, em 1981, impôs grandes mudanças ambientais, desmatamentos e migração para a região. O objetivo deste trabalho é verificar a influência destas mudanças na ocorrência da malária no Município de Jacundá, Pará, Brasil, utilizando-se técnicas de sensoriamento remoto e sistemas de informações geográficas. Os parâmetros utilizados para a construção dos mapas foram: distância das estradas, classe agrossilvopastoril, distância de coleções hídricas (rios, igarapés e do reservatório e da área urbana do município. Neste estudo, verificou-se o caráter epidêmico da malária a partir da construção da barragem de Tucuruí. Sugere-se que o padrão sazonal da incidência está relacionado com o período de maior estabilidade das margens do reservatório e ocorrência de áreas alagadas, além de maior exposição de trabalhadores na época de colheita na região. Foi observado que a distribuição dos casos está relacionada com as formas de uso e ocupação da terra, principalmente em áreas de maior influência das estradas, locais onde se concentra grande parte da população.Construction of the Tucuruí hydroelectric dam in Southeast Pará State, Brazil, in 1981, caused enormous environmental changes, deforestation, and human migration to the region. This study focuses on the influence of these changes and the appearance of malaria in the municipality of Jacundá, Pará, using remote sensing and geographic information systems. The variables used to construct maps were distances from roads, farming areas, rivers, the dam, streams, and the urban area. This study confirmed the elevation of malaria to the epidemic level since the construction of the Tucuruí dam. The study suggests that a seasonal pattern of malaria incidence is associated with the flooding season and exposure of workers during harvest. Malaria cases were related to the form of

  8. Estudo sobre a eventual utilidade de raios gama na profilaxia da malária transmissível por transfusão de sangue A study on the fortuitons advantage of gamma irradiation in the prophylaxis of transmissible malaria by blood transfusion

    Directory of Open Access Journals (Sweden)

    Lúcia Maria Almeida Braz

    1998-12-01

    Full Text Available O estudo foi realizado com o objetivo de avaliar a eventual utilidade de raios gama na profilaxia da malária transmissível por transfusão de sangue, tendo sido, para isso, usados camundongos infectados pelo Plasmodium berghei. Na primeira fase, quando submetemos sangue deles retirado a 2.500 e 5.000rad, com associação ou não de metronidazol, não obtivemos sucesso, já que todos os animais antes sem a parasitose apresentaram parasitemia e morreram após inoculação do sangue irradiado. Porém, ocorreu êxito parcial na segunda fase, ao serem empregados 10.000 e 15.000rad, porquanto 20% e 40% dos roedores, respectivamente, embora tenham ficado infectados, sobreviveram, com posterior negativação quanto à presença do P. berghei.This study was carried out to evaluate the fortuitons advantage of using gamma irradiation in the prophylaxis of transmissible malaria by blood transfusion, with mice as the experimental model. In the first step, when the infected blood with Plasmodium berghei was submitted to 2,500rad and 5,000rad, with or without metronidazol, there was no success, because the animals presented parasitaemia and died after inoculation of irradiated blood. However, there was partial success in the second step, when the infected blood received 10,000 and 15,000rad, and was inoculated in mice, which showed infection, and presented a survival rate of 20% and 40%, respectively, with later negativation of blood infected by P. berghei.

  9. Baixa aderência e alto custo como fatores de insucesso do uso de mosquiteiros impregnados com inseticida no controle da malária na Amazônia Brasileira Low adherence and high cost as failure factors of impregnated bed nets with insecticide for malaria control in the Brazilian Amazon

    Directory of Open Access Journals (Sweden)

    João Barberino Santos

    1999-08-01

    Full Text Available Em 1992, durante um ensaio com mosquiteiros impregnados com deltametrina, conduzido em Porto Murtinho, município de Costa Marques, Rondônia, na Amazônia Brasileira, analisou-se a aderência e os fatores econômicos capazes de reduzir o impacto do uso de mosquiteiros impregnados sobre a morbidade da malária. Os mosquiteiros impregnados tiveram excelente receptividade pela população local. No entanto, a aderência foi muito baixa, principalmente pelos adultos maiores de 15 anos de idade e, durante a estiagem. O preço do mosquiteiro impregnado foi calculado em US$18,83 para casal e, em US$13,82, para solteiro. Apesar das vantagens econômicas do emprego dos mosquiteiros impregnados em larga escala, desde que subsidiados pelas agências governamentais, a baixa aderência verificada, aliada aos fatores epidemiológicos locais, não permitem indicar o uso de mosquiteiros impregnados como medida de proteção em massa na Amazônia.In 1992 during a trial with deltamethrin-impregnated bed nets conducted in Porto Murtinho, municipality of Costa Marques, Rondonia, in the Brazilian Amazon, we investigated community compliance and the economic aspects capable of reducing the impact of this intervention on malaria morbidity. Impregnated bed nets were well accepted by the local population. However, compliance was found to be very low among adults over 15 years of age and mainly during the dry season. The cost of impregnated bed nets was US$18.83 for double-bed nets and US$13.82 for single bed nets. Despite the economic advantages of using impregnated bed nets subsidized by the government, the low compliance and local epidemiological factors do not allow to indicate the use of impregnated bed nets for mass malaria control in the Amazon region.

  10. Aspectos sócio-econômicos dos indivíduos com malária importada na região metropolitana de São Paulo, Brasil: I - Caracterização da população e conhecimento sobre a doença Social and economic aspects of patients with imported malaria in the metropolitan region of S. Paulo City, S. Paulo State, Brazil: I - Characterization of the population and knowledge of the disease

    Directory of Open Access Journals (Sweden)

    Maria José Chinelatto Pinheiro Alves

    1990-08-01

    Full Text Available Com o objetivo de conhecer o perfil sócio-econômico dos indivíduos que se deslocaram das áreas endêmicas de malária do país, foram estudadas 566 pessoas com suspeita de malária que procuraram a confirmação diagnostica no Laboratório de Malária da Região Metropolitana de São Paulo da Superintendência de Controle de Endemias (SUCEN. As informações foram obtidas através da aplicação de formulário, no período de novembro de 1986 a junho de 1987. Da população estudada, 345 (61,0% residiam na área endêmica, 479 (84,6% eram do sexo masculino, 513 (90,7% estavam na faixa etária de 15 a 55 anos e 307 (54,2% apresentaram hemoscopia positiva para plasmódio. Com relação à ocupação na área de transmissão, observou-se que 109 (19,3% estavam ligados a atividade de extração de minerais, 74 (13,2% à agricultura e 46 (8,1% à atividade de transporte. A análise da escolaridade mostrou que 486 (85,9% tinham 1° ou 2° grau. Quanto ao conhecimento sobre a doença, 384 (67,8% declararam pelo menos 1 malária anterior e 491 (86,8% associavam à doença a presença do vetor. Dentre os 221 indivíduos residentes em São Paulo, 207 (93,7% conheciam o risco de contrair malária por ocasião do deslocamento para área de transmissão. Daqueles residentes na área endêmica, 336 (97,4% tinham conhecimento do risco de contrair a doença naquela região. O intervalo transcorrido entre os primeiros sintomas e a procura de atendimento médico em 386 (68,2% indivíduos variou de 0 a 3 dias. As freqüências das variáveis estudadas mostraram de acordo com o resultado hemoscópico e o local da residência, diferenças estatísticas relevantes.With a view to discovering the social and economic characteristics of people from endemic malarial areas of Brazil, 566 suspected malaria cases were studied at the S. Paulo City Metropolitan Region Malaria Laboratory. Data were obtained by means of the application of standardized questionnaires over the

  11. Compatibilidade de Dicyma pulvinata com defensivos agrícolas e eficiência do biocontrole do mal-das-folhas da seringueira em campo Compatibility of Dicyma pulvinata with pesticides and biocontrol efficiency of South American leaf blight of rubber tree under field conditions

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    Débora Ferreira Melo

    2008-02-01

    Full Text Available O objetivo deste trabalho foi avaliar quatro isolados do fungo antagonista Dicyma pulvinata quanto à compatibilidade com defensivos agrícolas e adjuvantes, e a eficiência desses isolados no controle do mal-das-folhas (Microcyclus ulei da seringueira (Hevea sp. em campo. A compatibilidade dos isolados com defensivos e adjuvantes foi avaliada com base no crescimento micelial e na esporulação do fungo, em testes conduzidos in vitro. Para avaliação da eficiência do antagonista contra M. ulei, em campo, os quatros isolados do antagonista foram comparados ao controle exercido pelo tratamento com os fungicidas propiconazol + mancozeb. Os ensaios conduzidos em laboratório indicaram a incompatibilidade de D. pulvinata com os fungicidas benomyl, carbendazim, mancozeb, propiconazol e, ainda, com o inseticida acaricida endosulfan. Dois dos adjuvantes testados (Tween 20 e Tween 80 não afetaram o desenvolvimento do fungo. Foi comprovada a ação do antagonista D. pulvinata sobre M. ulei, em campo, com destaque para os isolados CEN 62 e CEN 93, que apresentaram eficiência de controle semelhante ao tratamento fungicida padrão.The objective of this work was to evaluate four isolates of the antagonist fungus Dicyma pulvinata in terms of its compatibility with chemical pesticides and adjuvants products, and the efficiency of these isolates as biocontrol agent against South American leaf blight (Microcyclus ulei of rubber tree (Hevea sp. under field conditions. Isolates compatibility with chemical pesticides and adjuvants was evaluated on mycelial growth and fungus sporulation in vitro. To assess the efficiency of the antagonist against M. ulei under field conditions, the four isolates were compared to the control by the fungicide mixture propiconazol + mancozeb. The assays showed incompatibility of the antagonistic fungus with the fungicides benomyl, carbendazim, mancozeb, propiconazol, besides the insecticide-acaricide endosulfan. Two of the adjuvants

  12. Avaliação dos níveis das transaminases dos pacientes com infecção pelo Plasmodium vivax atendidos em um centro de referência para tratamento da malária no Estado de Mato Grosso

    Directory of Open Access Journals (Sweden)

    Elisane de Freitas Pereira

    2017-11-01

    Full Text Available Objetivo: Analisar os marcadores hepáticos (transaminases em pacientes com malária causada pelo Plasmodium vivax. Métodos: Trata-se de um estudo transversal retrospectivo, incluindo pacientes que apresentaram monoinfecção pelo P. vivax. O teste de Mann-Whitney U ou o teste t de Student foram utilizados para comparar a atividade média das transaminases de acordo com a classificação clínica e epidemiológica do paciente infectado. O teste de Kruskal-Wallis foi utilizado para comparar a média da atividade das transaminases de acordo com a classificação da infecção. Valores de p<0,05 foram considerados significativos. Resultados: Indivíduos menores de 7 anos apresentaram maior atividade da transaminase glutâmico oxalacética (TGO e da transaminase glutâmico pirúvica (TGP — respectivamente, 68,7 U/L e 79,8 U/L — em relação a pacientes com idade de 8 a 59 anos (TGO 29,8 U/L e TGP 39,2 U/L e acima de 60 anos (TGO 32,5 U/L e TGP 34 U/L. A média da dosagem sérica de TGO de todos os pacientes incluídos no estudo foi de 31,99 U/L e de TGP foi de 41,1 U/L. A atividade de TGP nos pacientes primoinfectados foi maior que nos reinfectados ou com recaída, sendo 65,6 U/L contra 36,2 U/L e 32,7 U/L, respectivamente. Conclusão: Crianças apresentam maior atividade de transaminases que os indivíduos maiores de sete anos de idade. Pacientes com infecção prévia pelo P. vivax apresentam menores valores séricos da atividade das transaminases do que os primoinfectados. Indivíduos com episódios de recaída apresentam menores valores das enzimas avaliadas do que aqueles com reinfecção ou primoinfecção.

  13. Malaria transmission model for different levels of acquired immunity and temperature-dependent parameters (vector Modelo de transmissão de malária em diferentes níveis de imunidade e de parâmetros temperatura-dependentes (vetor

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    Hyun M Yang

    2000-06-01

    Full Text Available OBJECTIVE: Describe the overall transmission of malaria through a compartmental model, considering the human host and mosquito vector. METHODS: A mathematical model was developed based on the following parameters: human host immunity, assuming the existence of acquired immunity and immunological memory, which boosts the protective response upon reinfection; mosquito vector, taking into account that the average period of development from egg to adult mosquito and the extrinsic incubation period of parasites (transformation of infected but non-infectious mosquitoes into infectious mosquitoes are dependent on the ambient temperature. RESULTS: The steady state equilibrium values obtained with the model allowed the calculation of the basic reproduction ratio in terms of the model's parameters. CONCLUSIONS: The model allowed the calculation of the basic reproduction ratio, one of the most important epidemiological variables.OBJETIVO: Propõe-se um modelo compartimental para descrever a transmissão de malária, levando em consideração duas populações envolvidas: o hospedeiro humano e o vetor mosquito. MÉTODOS: Desenvolveu-se um modelo matemático baseado nas seguintes características: em relação ao hospedeiro humano, assumiu-se a existência de imunidade adquirida e de memória imunológica que, em uma reinfecção, leva ao reforço da resposta imune; em relação ao vetor mosquito, levou-se em consideração que o período médio de desenvolvimento desde ovo até mosquito adulto e o período de incubação extrínseco de parasitas (transformação de mosquitos infectados mas não-infecciosos em mosquitos infecciosos são dependentes de temperatura ambiente. RESULTADOS: Foram obtidos os valores do equilíbrio no estado estacionário do modelo proposto. Da análise da estabilidade dos pontos de equilíbrio, foi determinada a razão de reprodutibilidade basal. CONCLUSÕES: Foi obtida uma variável epidemiológica importante, a razão de

  14. Variable impact of Malaysia's national language planning on non-Malay speakers in Sarawak Impacto variável do planejamento linguístico nacional da Malásia sobre não falantes do Malaio em Sarawak

    Directory of Open Access Journals (Sweden)

    Su-Hie Ting

    2012-06-01

    Full Text Available The study examined the impact of the national language policy on the language use of three main ethnic groups in the Malaysian state of Sarawak. The data analyzed was based on a sociolinguistic survey on language use in six domains that involved 937 Malay, Chinese and Iban adolescents from three major towns in Sarawak. The results showed that the use of Bahasa Malaysia exceeded English usage for all three ethnic groups, showing the success of compulsory education in the national language. However, the language planning has greater impact on the Iban than on the Chinese who are shifting away from the ethnic languages of the Chinese sub-groups to Mandarin Chinese. The availability of an alternative standard language with international standing which also functions as a symbol of cultural solidarity compromises the impact of the national language policy.Este estudo examinou o impacto da política de ensino da língua nacional de três principais grupos étnicos no estado malaio de Sarawak. Os dados analisados basearam-se em uma pesquisa sociolinguística sobre o uso da língua em seis domínios e envolveu 937 adolescentes malaios, chineses e Iban de três grandes cidades de Sarawak. Os resultados mostraram que o uso da língua Bahasa da Malásia superou o uso do inglês para todos os três grupos étnicos, comprovando o sucesso da escolaridade obrigatória em língua nacional. No entanto, o planejamento do estudo da língua tem maior impacto sobre o Iban do que sobre os chineses. Estes estão se afastando das línguas étnicas dos subgrupos chineses para o chinês Mandarim. A disponibilidade de uma língua alternativa padrão, com prestígio internacional, que também funciona como um símbolo de solidariedade cultural, compromete o impacto da política de ensino da língua nacional.

  15. Du Mal-être au votre extrême

    OpenAIRE

    Gethin,, Amory; Jenmana,, Thanasak

    2017-01-01

    Note d'analyse de l'Observatoire du Bien-être du CEPREMAP; The rise of populism and the failure of traditional parties during the 2017 French presidential election calls to question the relevance of traditional determinants of voting. Given the difficult economic context associated with François Hollande’s term, to what extent has the increasing pessimism in France contributed towards anti-establishment voting?Available surveys reveal two remarkable phenomena. The extremes, particularly the e...

  16. Problematica del mal de las vacas locas y consecuencias

    OpenAIRE

    Fernandez Boj, Olga

    2003-01-01

    El presente trabajo se basa en el estudio sobre una enfermedad que causa una especie de locura en los bovinos denominada encefalitis espongiforme bovina, (EEB) y que también puede afectar al hombre con el nombre de Creutzfeldt-Jakob. La EEB (enfermedad espongiforme bovina) esta vinculada con el scrapie una enfermedad también prionica que se conoce desde hace 250 años y que afecta a las ovejas. Todo comenzó 1883 cuando una vaca tenia los mismos signos clínicos que las ovejas, per...

  17. Videogame: é do bem ou do mal? Como orientar pais

    Directory of Open Access Journals (Sweden)

    Luciana Alves

    2011-06-01

    Full Text Available Desde a década de 70 milhares de crianças, adolescentes e adultos praticam jogos de computador ou videogame. O objetivo deste artigo foi identificar os efeitos deste artefato tecnológico para a cognição, sua aplicabilidade e sua influência sobre o comportamento e a saúde do jogador e, desta forma, delinear orientações para pais e profissionais de saúde que lidam com crianças e adolescentes. Na primeira parte do artigo são apresentados alguns efeitos negativos e positivos dos jogos; na segunda é proposto um conjunto de orientações que podem tornar a brincadeira mais segura; e na última parte, as considerações finais. Concluiu-se que o videogame é uma ferramenta capaz de aperfeiçoar as habilidades cognitivas e perceptivas, sendo os jogos educacionais apontados como uma experiência benéfica aos seus usuários, e que as repercussões negativas se referem, principalmente, ao efeito daqueles com conteúdo de violência.

  18. PROBLEMAS INVERSOS MAL COLOCADOS EM QUÍMICA

    Directory of Open Access Journals (Sweden)

    João P. Braga

    Full Text Available What is an ill-posed inverse problem? The answer to this question is the main objective of the present paper and the pre-requisite to follow the material requires only elementary calculus. The first mathematical formulation of an inverse problem, due to N. H. Abel, together with the fundamental work by Jacques Hadamard, are explored at the beginning of the paper. A prototype system is used to consider the regularization concept. Three numerical methods, the Tikhonov regularization, the decomposition into singular values and the Hopfield neural networks, applied to remove the singularity are examined. General aspects of the ill-posed inverse problems in chemistry with emphasis in thermodynamics and a set of general rules for other areas of science are also analyzed.

  19. O mal-estar docente em gestores escolares

    Directory of Open Access Journals (Sweden)

    Cátia Cristina Xavier Mazon

    2013-08-01

    Full Text Available This research aimed to identify and analyze the impact of stressful events associated with the school administrators in teacher malaise. 29 managers participated in his capacity as directors or deputy directors of the municipal system, the interior of São Paulo, with responses to the Inventory IMPIL (Evaluación Psicológica Del Estrés por InestabilidadLaboral - FIGUEROA; SCHUFER, 2006. The results indicate the presence of stressors in all areas assessed at different rates. The highest ranking stressors were concerns with health, emotional Diseases and economic concerns. The degree of discomfort tends to increase with age, but since the entry into this function. The extensive powers of management, indicate the occurrence of different degrees of impact between the groups, demonstrating that subjectivity needs to be considered for proposing improvements in working conditions and health organizations. Social changes, the demands of educational reforms and lack of recognition of the profession were associated with teacher malaise.

  20. Observation of the new isomer 32mAl

    International Nuclear Information System (INIS)

    Robinson, M.; Halse, P.; Lewitowicz, M.; Saint-Laurent, M.G.

    1995-01-01

    A new isomer in the neutron-rich isotope 32 Al has been identified among the fragmentation products of a 40 Ar 16+ beam using the LISE spectrometer at GANIL. The population of the isomeric state was inferred from the detection of γ-radiation following its decay in coincidence with its respective heavy-ion implantation signal. The half-life of 32m Al was determined to be 240 ± 30 ns. (author)

  1. MAL MEDIS DI MAKASSAR DENGAN PENDEKATAN BANGUNAN SEHAT

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    Nurpuspitasari Nurpuspitasari

    2014-12-01

    Full Text Available These planning and designing are aimed to design Medical Mall in Makassar with healthy building approach, although in macro such as deciding the location and footprint, and also in micro such as deciding the form and its appearance, program, measuring rooms and relating each rooms, structure, material, until its equipments. The method which is used is Descriptive, the data comes from secondary data, those are literature study through books, short papers, references, standard, internet and others written sources that is related with planning and designing Medical mall in Makassar with healthy building approach. The results of these designing are creating a place in servicing health and others facilities supporting medical health in a integrated building, that is based comfortable and save environment fulfill requirements of physiological, psychological and free from spreading diseases

  2. Tvorba marketingové strategie malé firmy

    OpenAIRE

    Šťastná, Jana

    2011-01-01

    This bachelor thesis deals with marketing strategy of mid-sized company called TRIPOR Ltd., the business deals with buying and selling porcelain and glass .The business is located in Klášterec nad Ohří. The aim of this work is to analyze the current marketing strategy of the company, its evaluation, suggestion and marketing strategy of the company. The work is divided into two chapters. The first chapter deals with the theoretical part, which describes the particular theory of marketing. The ...

  3. Shale engineering application: the MAL-145 project in West Virginia

    Energy Technology Data Exchange (ETDEWEB)

    Vassilellis, George D.; Li, Charles; Bust, Vivian K. [Gaffney, Cline and Associates (United States); Moos, Daniel; Cade, Randal [Baker Hughes Inc (United States)

    2011-07-01

    With the depletion of conventional fossil fuels and the rising energy demand, oil shale and shale gas are becoming an important component of the oil and gas markets in North America. The aim of this paper is to present a novel methodology for predicting production in shale and tight formations. This method, known as the shale engineering approach and modeling, provides reservoir simulations based on modeling the propagation of the simulated rock volume. This technique was applied to an Upper Devonian shale formation in West Virginia, United States, and was compared to available data such as production logs and downhole microseismic data. Results showed a good match between the shale engineering approach data and early well performance. This paper presented a new reservoir simulation methodology which is successful in forecasting production and which can also be used for field development design and optimization.

  4. Cephalopods belong to a very diverse group of ani- mals ...

    African Journals Online (AJOL)

    spamer

    Rosen 1979). Exploitation of cephalopods is on the increase .... factors, rather than a single parameter (e.g. temperature). Cause-and-effect elements between these modifiers are integral to the ..... illecebrosus, in the Northwest Atlantic. Aquat.

  5. O mal-estar docente em gestores escolares

    Directory of Open Access Journals (Sweden)

    Cátia Cristina Xavier Mazon

    2013-01-01

    Full Text Available Esta investigación tuvo como objetivo identificar y analizar el impacto de eventos estresantes en los administradores de escuelas asociado al malestar docente. Participaron 29 administradoras en su calidad de directoras o subdirectoras de la red municipal del interior del Estado de São Paulo, con las respuestas a la IMPIL (Evaluación Psicológica Del Estrés por Inestabilidad Laboral - FIGUEROA; SCHUFER, 2006. Los resultados indican la presencia de factores estresantes en todas las áreas evaluadas en diferentes índices. Los mayores factores de estrés fueron las preocupaciones con la salud, enfermedades emocionales y las preocupaciones económicas. El grado de molestia tiende a aumentar con la edad, pero están presentes en esta función desde su iniciación. Los amplios poderes de gestión, indican la ocurrencia de diferentes grados de impacto entre los grupos, demostrando que la subjetividad debe ser considerada para las propuestas de mejoras de las condiciones de trabajo y organizaciones de salud. Las aceleradas transformaciones sociales, las exigencias de reformas educativas y la falta de reconocimiento de la profesión se asociaron al malestar docente.

  6. Daytime encopresis associated with gland mal epileptic seizures: case report.

    Science.gov (United States)

    Oyatsi, D P

    2005-08-01

    Sphincteric incontinence of stool and urine are not unusual features of generalised epileptic seizures. Isolated secondary encopresis as a manifestation of an epileptic seizure is unusual. This report is of, a four year old boy, with daytime secondary non-retentive encopresis. The onset of encopresis was preceded by several episodes of nocturnal generalised tonic clonic epileptic seizures. An electroencephalogram showed features consistent with complex partial seizures. He was commenced on anti-epileptic treatment with phenytoin sodium, and by the third day of treatment, the patient had achieved stool control.

  7. ‘Comprendre le mal extrême.’

    Directory of Open Access Journals (Sweden)

    Christian Ruby

    2003-10-01

    Full Text Available Fondée sur l'exercice d'une terreur politique et sur un processus d'extermination radicale, une nouvelle forme de pouvoir d'État est née au 20 e  siècle. Afin de parler avec précision de cette nouvelle réalité, il fallait forger un concept encore inédit dans les typologies du pouvoir léguées par Platon et Montesquieu. La philosophe allemande (émigrée aux États-Unis, où elle prendra la nationalité américaine Hannah Arendt a proposé, en 1951, le concept de ...

  8. Obchodní strategie malého podniku

    OpenAIRE

    Hourová, Tereza

    2013-01-01

    The thesis deals with the business strategy of a middle-sized entrepreneur in the food manufacturing industry. The theoretical part explains basic terms, introduces methods of a strategic analysis and describes basic approaches to formulating the strategy. The practical part contains the strategic analysis of a specific entrepreneur created using the PEST analysis, the Porter five forces analysis, and the Value Chain Analysis. The practical part also includes suggested business strategies det...

  9. O CUIDADOR DOMICILIAR DE PACIENTE IDOSO COM MAL DE ALZHEIMER

    Directory of Open Access Journals (Sweden)

    Rafaelle Lins Barbosa

    2012-01-01

    Full Text Available Se trata de estudio de caso con objetivo de entender cómo la atención diaria en casa, en la perspectiva del cuidador familiar de anciano con la Enfermedad de Alzheimer. El estudio fue llevado a cabo con un cuidador familiar en la ciudad de Alfenas-MG, Brasil, de mayo y junio de 2010, a través de entrevista con pregunta directa. Fueron identificados dos categorías: el cuidado tomado con el paciente con Alzheimer y el cuidador del paciente con Alzheimer. El cuidador en la atención diaria dedica su tiempo integral, vive dificultades financieras y de convivio con cambios del paciente, contemplando en carga excesiva diaria que compromete el ocio y genera problemas de salud, mientras buscando el apoyo en la fe. Aprehender las dificultades enfrentadas por el cuidador propicia el equipo de salud para direccionar y llevar a cabo estrategias de apoyo para el cuidador enfrentar la condición crónica del familiar.

  10. Mal-estar no pós-neoliberalismo

    Directory of Open Access Journals (Sweden)

    Jamie Peck

    2012-03-01

    Full Text Available O início da crise financeira global em 2008 foi interpretado como um desafio fundamental à governança neoliberal. O artigo explora algumas das consequências de curto e longo prazo da crise econômica em relação aos processos da neoliberalização e propõe referências teóricas para uma compreensão adequada da natureza desse modelo político e socioeconômico e de suas manifestações e desenvolvimentos socioespaciais.The onset of the global financial crisis has been widely interpreted as a fundamental challenge to neoliberal governance. The article explores some of the near-term and longer-run consequences of the economic crisis for processes of neoliberalization, suggesting some theoretical references for the adequate understanding of the nature of neoliberalization and its evolving sociospacial manifestations.

  11. Meio ambiente e saúde: metodologia para análise espacial da ocorrência de malária em projetos de assentamento Medio ambiente y salud: metodología para análisis espacial de la ocurrencia de malaria en proyectos de asentamiento Environment and Health: a methodological approach for spatial assessment of malaria transmission in colonization projects in the Brazilian Amazon

    Directory of Open Access Journals (Sweden)

    Marcia Caldas de Castro

    2007-12-01

    Full Text Available A transmissão de malária em projetos de assentamento na Amazônia, definida como malária de fronteira, é resultado de um intrincado processo envolvendo fatores biológicos, ecológicos, socioeconômicos e comportamentais, apresentando uma transição temporal de altas a baixas taxas ao longo de aproximadamente oito anos. Como resultado, um dos grandes desafios é a compreensão desse processo, através da identificação das variáveis determinantes da transmissão, considerando-se dimensões temporais e espaciais. Neste artigo é apresentada uma abordagem metodológica que caracteriza perfis de risco de malária em projetos de assentamento, a partir de uma análise multidisciplinar. Composta de três etapas, a abordagem combina análise espacial, geoestatística e modelos de Grade of Membership. Os resultados ressaltam a importância de medidas de controle diferenciadas de acordo com o estágio do projeto de assentamento (implementação recente ou antiga e o nível de transmissão em cada localidade.La transmisión de malaria en proyectos de asentamiento en la Amazonia, definida como malaria de frontera, es el resultado de un intrincado proceso, involucrando factores biológicos, ecológicos, socioeconómicos y comportamentales, presentando una transición temporal de altas a bajas tasas a lo largo de aproximadamente ocho años. Como resultado, uno de los grandes desafíos es la comprensión de ese proceso, a través de la identificación de las variables determinantes de la transmisión, habiéndose considerado dimensiones temporales y espaciales. En este artículo es presentado un abordaje metodológico que caracteriza perfiles de riesgo de malaria en proyectos de asentamiento, a partir de un análisis multidisciplinario. Compuesto de tres etapas, el abordaje combina análisis espacial, geoestadística y modelos de Grade of Membership. Los resultados resaltan la importancia de medidas de control diferenciadas, de acuerdo a la etapa del

  12. Malária não complicada por Plasmodium vivax e P. falciparum no Brasil: evidências sobre fármacos isolados e associações medicamentosas empregados em esquemas terapêuticos recomendados pelo protocolo terapêutico oficial Uncomplicated Plasmodium vivax and P. falciparum malaria in Brazil: evidence on single and combined drug treatments recommended by official guidelines

    Directory of Open Access Journals (Sweden)

    Letícia Figueira Freitas

    2007-10-01

    Full Text Available A malária é a endemia parasitária mais importante no mundo. No Brasil, 60% do território são favoráveis à transmissão, com cerca de 500 mil casos por ano. A doença não se distribui geograficamente de forma homogênea, fato que pode explicar diferenças na eficácia e efetividade dos tratamentos. Para identificar as evidências que poderiam ter embasado os tratamentos recomendados pelo Manual de Terapêutica da Malária 2001, foi realizada uma revisão dos estudos que abordassem tratamentos com antimaláricos no Brasil entre 1980 e 2005. Foram encontrados poucos estudos, e com baixa qualidade metodológica, nenhum deles capaz de gerar recomendações para protocolos baseados em evidência. Os artigos publicados após 2001 apresentaram nível de evidência maior, segundo classificação utilizada para definição de níveis de evidência farmacológico-clínicos. Espera-se que tais estudos também orientem conduta na próxima revisão do manual, prevista para o ano de 2007. Constatou-se que as referências do manual, utilizadas como base para recomendação dos tratamentos, são publicações desatualizadas e possivelmente consideradas clássicas, mas com pouca especificidade para região geográfica, população e/ou tipo de malária.Malaria is the most important endemic parasitic disease in the world. Conditions are favorable for transmission of the disease in 60% of Brazil's territory. Over 500,000 cases per year are recorded in the country. However, the geographic distribution is uneven, which may explain differences in the efficacy and effectiveness of antimalarial drugs. We conducted an extensive literature review of antimalarial treatment in Brazil from 1980 to 2005 in order to identify evidence that might have been available for the 2001 Edition of the Malaria Treatment Manual, the official Ministry of Health guidelines. Only a few studies, of low methodological quality, were identified by the search. None of the studies would

  13. Estrutura comunitária e amplitude ecológica do componente lenhoso de uma floresta de restinga mal drenada no sudeste do Brasil Woody-layer structure and ecological amplitude of a poorly drained beach-ridge forest in southeastern Brazil

    Directory of Open Access Journals (Sweden)

    Luis Fernando Tavares de Menezes

    2010-09-01

    Full Text Available Analisamos a estrutura de uma floresta mal drenada na Restinga da Marambaia, RJ, e a amplitude ecológica das espécies quanto à tolerância à inundação do solo. Foram amostrados em 50 parcelas contíguas de 10 X 10m (0,5 ha, indivíduos com diâmetro do caule a altura do peito (DAP >2,5 cm. Registramos 1.223 indivíduos vivos (distribuídos em 24 famílias, 43 gêneros e 57 espécies. O índice de diversidade de Shannon (H' foi de 2,87 e a equabilidade (J' foi de 0,68. A densidade total foi de 2.446 ind. ha-1 e a área basal de 25,14 m². ha-1. As famílias mais ricas em espécies foram Myrtaceae (13, Leguminosae (5, Annonaceae, Euphorbiaceae, Myrsinaceae e Sapindaceae (4. Dez espécies apresentaram valor de importância (VI acima de nove, correspondendo o somatório de seus valores a 75% do VI total. As espécies com maiores valores de VI foram Tapirira guianensis Aubl. (42,42, Amaioua intermedia Mart. ex Roem. & Schult. (40,77 e Chaetocarpus myrsinites Baill. (39,98, que juntas detiveram 41% do VI total. A comunidade arbórea analisada foi composta principalmente por espécies preferenciais de áreas secas, ou seja, espécies com preferência por alagamento periódico do solo ou solos mais secos, mas não com alagamento permanente ou quase permanente do solo. A maior similaridade da floresta mal drenada da Marambaia foi observada com as florestas inundáveis do Parque Nacional de Jurubatiba, RJ (21,4 e 23,8%. Nossos resultados permitiram concluir que não existe uma flora particular para as formações inundáveis nas restingas do sul e sudeste brasileiro e que mudanças do padrão florístico da vegetação dessas áreas ocorrem em função da proximidade da fonte de propágulos de espécies com alta tolerância à inundação do solo e secundariamente relacionada a questões fitogeográficas, ligadas à limitação da distribuição de espécies pelas condições climáticas das regiões subtropicais.We analyzed the structure of a

  14. ВТОРИННІ ПРЕДИКАТИ З АДВЕРБІАЛЬНИМ ЗНАЧЕННЯМ У ВЧЕННІ С. СМАЛЬ-СТОЦЬКОГО ТА ЇХ СУЧАСНІ РЕЦЕПЦІЇ / SECONDARY PREDICATES WITH ADVERBIAL SEMANTICS IN THE TEACHINGS OF S. SMAL-STOTSKY AND MODERN RECEPTION

    Directory of Open Access Journals (Sweden)

    Олена КУЛЬБАБСЬКА

    2016-12-01

    Full Text Available Кульбабская Е. Вторичные предикаты с адвербиальной семантикой в учении С. Смаль-Стоцкого и их современные рецепции. В статье описаны конструкции с пропозитивным потенциалом, которые в простом неэлементарном предложении реализованы многочисленными семантическими и морфологическими вариантами, репрезентируют побочную ситуацию, увеличивают информационный объём высказывания. Особое внимание сконцентрировано на предложноименных конструкциях, способных выражать различные оттенки семантики, в том числе адвербиальной. Определена роль в теории сокращенных предложений С. Смаль-Стоцкого и Ф. Гартнера в современных научных парадигмах. Ключевые слова: грамматика, вторичная предикация, неэлементарное про стое пр ед ло жение, втори чна я пропозиция, вторичные семантико - синтаксические отношения, адвербиальные предикатные синтаксемы, предложноименные комплексы, функции. Kulbabska Olena. Secondary predicates with adverbial semantics in the teachings of S. Smal-Stotsky and modern reception. The article reveals the scientific foundations of „Rus Language Grammar” by Stepan Smal-Stotsky and Fedir Gartner, emphasizes the topicality of vfny views of Stepan Smal-Stotsky, a scholar-patriot, his extremely important role in the

  15. Suspeita de Apneia Obstrutiva do Sono definida pelo Questionário de Berlim prediz eventos em pacientes com Síndrome Coronariana Aguda Sospecha de apnea obstructiva del sueño definida por el cuestionario de Berlín predice eventos en pacientes con síndrome coronario agudo Suspicion of Obstructive Sleep Apnea by Berlin Questionnaire predicts events in patients with Acute Coronary Syndrome

    Directory of Open Access Journals (Sweden)

    Eryca Vanessa S. de Jesus

    2010-09-01

    extras a la homeostasis cardiovascular en la presencia del síndrome coronario aguda (SCA OBJETIVO: Investigar si un diagnóstico clínico estandarizado de SAOS, en pacientes con SCA, predice el riesgo de eventos cardiovasculares durante la hospitalización. MÉTODOS: En un estudio de cohorte prospectivo, un grupo de 200 pacientes con diagnóstico de SCA elecido entre Septiembre de 2005 y Noviembre de 2007, fueron estratificados por el Cuestionario de Berlín (CB para el riesgo de SAOS (alto o bajo riesgo. Se probó si el subgrupo de alto riesgo para SAOS presenta mayor tendencia a eventos cardiovasculares. El endpoint primario evaluado fue un desenlace conformado por muerte cardiovascular, eventos cardíacos isquémicos recurrentes, edema pulmonar agudo y accidente vascular cerebral durante la hospitalización. RESULTADOS: Noventa y cuatro (47% de los pacientes identificados por el CB presentaban sospecha de SAOS. Alto riesgo para SAOS estaba asociado con una mortalidad más elevada, aunque sin diferencia estadística (4,25% vs 0,94%; p=0,189, pero con una estadísticamente significativa mayor incidencia de desenlace conformada por eventos cardiovasculares (18,08% vs 6,6%; p=0,016. En el modelo de regresión logística, los predictores multivariados de desenlace conformado por eventos cardiovasculares fueron edad (OR= 1,048; IC95%: 1,008 a 1,090; p=0,019, fracción de eyección del VI (OR= 0,954; IC95%: 0,920 a 0,989; p=0,010, y riesgo más elevado de SAOS (OR= 3,657; IC95%: 1,216 a 10,996; p=0,021. CONCLUSIÓN: El uso de un cuestionario sencillo y validado (CB para identificar a pacientes con riesgo más elevado de SAOS puede ayudar a prever el desenlace cardiovascular durante la hospitalización. Además de ello, nuestros datos sugieren que SAOS es mucho común en pacientes con SCA.BACKGROUND: From a mechanistic standpoint, obstructive sleep apnea (OSA may further disturb cardiovascular homeostasis in the setting of acute coronary syndrome (ACS. OBJECTIVE: We sought

  16. Parenting Styles as Predicators of Anxiety and Depression of In-School Adolescents in Nigeria

    Science.gov (United States)

    Adubale, Andrew A.

    2017-01-01

    The study investigates parenting styles as predictors of anxiety and depression in secondary school students in Edo State, Nigeria. It employed a correlation research design. Two hundred and forty students constituted the sample for the study. Parenting Style Scale questionnaire was used to collect data for the study. Linear regression was used to…

  17. Study of Predication of Multipactor%微放电效应预测研究

    Institute of Scientific and Technical Information of China (English)

    聂莹; 曹桂明

    2006-01-01

    分析了几种类型结构方同轴线的特性,利用FDTD数值方法对方同轴线的微放电效应阈值电平进行预测计算,并给出了阈值曲线.结合实验数据说明了预测方法是有效的,该阈值曲线可以作为微放电效应部件设计参考曲线.

  18. Options of system integrated environment modelling in the predicated dynamic cyberspace

    Energy Technology Data Exchange (ETDEWEB)

    Janková, Martina; Dvořák, Jiří [Institute of Informatics, Faculty of Business and Management, Brno University of Technology, Brno (Czech Republic)

    2015-03-10

    In this article there are briefly mentioned some selected options of contemporary conception of cybernetic system models in the corresponding and possible integratable environment with modern system dynamics thinking and all this in the cyberspace of possible projecting of predicted system characteristics. The key to new capabilities of system integration modelling in the considered cyberspace is mainly the ability to improve the environment and the system integration options, all this with the aim of modern control in the hierarchically arranged dynamic cyberspace, e.g. in the currently desired electronic business with information. The aim of this article is to assess generally the trends in the use of modern modelling methods considering the cybernetics applications verified in practice, modern concept of project management and also the potential integration of artificial intelligence in the new projecting and project management of integratable and intelligent models, e.g. with the optimal structures and adaptable behaviour.The article results from the solution of a specific research partial task at the faculty; especially the moments proving that the new economics will be based more and more on information, knowledge system defined cyberspace of modern management, are stressed in the text.

  19. Analysis of the frontier technology of agricultural IoT and its predication research

    Science.gov (United States)

    Han, Shuqing; Zhang, Jianhua; Zhu, Mengshuai; Wu, Jianzhai; Shen, Chen; Kong, Fantao

    2017-09-01

    Agricultural IoT (Internet of Things) develops rapidly. Nanotechnology, biotechnology and optoelectronic technology are successfully integrated into the agricultural sensor technology. Big data, cloud computing and artificial intelligence technology have also been successfully used in IoT. This paper carries out the research on integration of agricultural sensor technology, nanotechnology, biotechnology and optoelectronic technology and the application of big data, cloud computing and artificial intelligence technology in agricultural IoT. The advantages and development of the integration of nanotechnology, biotechnology and optoelectronic technology with agricultural sensor technology were discussed. The application of big data, cloud computing and artificial intelligence technology in IoT and their development trend were analysed.

  20. Experimental Study in Taguchi Method on Surface Quality Predication of HSM

    Science.gov (United States)

    Ji, Yan; Li, Yueen

    2018-05-01

    Based on the study of ball milling mechanism and machining surface formation mechanism, the formation of high speed ball-end milling surface is a time-varying and cumulative Thermos-mechanical coupling process. The nature of this problem is that the uneven stress field and temperature field affect the machined surface Process, the performance of the processing parameters in the processing interaction in the elastic-plastic materials produced by the elastic recovery and plastic deformation. The surface quality of machining surface is characterized by multivariable nonlinear system. It is still an indispensable and effective method to study the surface quality of high speed ball milling by experiments.

  1. Options of system integrated environment modelling in the predicated dynamic cyberspace

    International Nuclear Information System (INIS)

    Janková, Martina; Dvořák, Jiří

    2015-01-01

    In this article there are briefly mentioned some selected options of contemporary conception of cybernetic system models in the corresponding and possible integratable environment with modern system dynamics thinking and all this in the cyberspace of possible projecting of predicted system characteristics. The key to new capabilities of system integration modelling in the considered cyberspace is mainly the ability to improve the environment and the system integration options, all this with the aim of modern control in the hierarchically arranged dynamic cyberspace, e.g. in the currently desired electronic business with information. The aim of this article is to assess generally the trends in the use of modern modelling methods considering the cybernetics applications verified in practice, modern concept of project management and also the potential integration of artificial intelligence in the new projecting and project management of integratable and intelligent models, e.g. with the optimal structures and adaptable behaviour.The article results from the solution of a specific research partial task at the faculty; especially the moments proving that the new economics will be based more and more on information, knowledge system defined cyberspace of modern management, are stressed in the text

  2. Predicating from an Early Age: Edusemiotics and the Potential of Children's Preconceptions

    Science.gov (United States)

    Olteanu, Alin; Kambouri, Maria; Stables, Andrew

    2016-01-01

    This paper aims to explain how semiotics and constructivism can collaborate in an educational epistemology by developing a joint approach to prescientific conceptions. Empirical data and findings of constructivist research are interpreted in the light of Peirce's semiotics. Peirce's semiotics is an anti-psychologistic logic (CP 2.252; CP 4.551; W…

  3. In vitro anti-proliferative effect of interferon alpha in solid tumors: A potential predicative test

    International Nuclear Information System (INIS)

    Fuchsberger, N.; Kubes, M.; Kontsek, P.; Borecky, L.; Hornak, M.; Silvanova; Godal, A.; Svec, J.

    1993-01-01

    An in vitro test for the anti-proliferative effect of human leukocyte interferon (IFN-alpha) was performed in primary cultures of tumor cells obtained from 32 patients with either malignant melanoma (13), renal carcinoma (4) or bladder carcinoma (15). Our results demonstrated activity of IFN in all three groups of solid tumors. However, appreciable differences in sensitivity to anti-proliferative effect of IFN between individual tumors of the same type were found. The potential of this anti-proliferative test for prediction of treatment response in IFN-therapy is discussed. (author)

  4. UPAYA PENEGAKAN HUKUM ATAS INSIDER TRADING SEBAGAI KEJAHATAN ASAL (PREDICATE CRIME DALAM TINDAK PIDANA PENCUCIAN UANG

    Directory of Open Access Journals (Sweden)

    Firman Halawa

    2017-08-01

    Full Text Available Pasar Modal dapat menjadi sarana pencucian uang karena adanya investasi yang dilakukan dengan tujuan untuk menyamarkan atau menyembunyikan asal usul sumber investasi yang dimasukkan ke Pasar Modal.  Pemidanaan atas tindak pidana asal dan pemidanaan atas pemanfaatan hasil tindak pidananya yang kemudian dikenal dengan istilah tindak pidana pencucian uang. Tindak pidana pencucian uang berkaitan erat dengan pelanggaran-pelanggaran di pasar modal termasuk  insider trading. Namun kenyataan yang terjadi hingga saat ini belum ada suatu kasus tindak pidana pencucian uang yang kejahatan asalnya insider trading diajukan ke persidangan. 

  5. A ligand predication tool based on modeling and reasoning with imprecise probabilistic knowledge.

    Science.gov (United States)

    Liu, Weiru; Yue, Anbu; Timson, David J

    2010-04-01

    Ligand prediction has been driven by a fundamental desire to understand more about how biomolecules recognize their ligands and by the commercial imperative to develop new drugs. Most of the current available software systems are very complex and time-consuming to use. Therefore, developing simple and efficient tools to perform initial screening of interesting compounds is an appealing idea. In this paper, we introduce our tool for very rapid screening for likely ligands (either substrates or inhibitors) based on reasoning with imprecise probabilistic knowledge elicited from past experiments. Probabilistic knowledge is input to the system via a user-friendly interface showing a base compound structure. A prediction of whether a particular compound is a substrate is queried against the acquired probabilistic knowledge base and a probability is returned as an indication of the prediction. This tool will be particularly useful in situations where a number of similar compounds have been screened experimentally, but information is not available for all possible members of that group of compounds. We use two case studies to demonstrate how to use the tool. 2009 Elsevier Ireland Ltd. All rights reserved.

  6. ¿La Justicia en Selección Predice las Intenciones de los Candidatos?

    Directory of Open Access Journals (Sweden)

    Amparo Osca

    2009-01-01

    Full Text Available El estudio analiza las relaciones entre la justicia en selección de personal y las intenciones respecto a la empresa/organización. Para ello se consultó a 261 candidatos reales después de conocer los resultados de un proceso de selección. Se analiza la justicia en los procedimientos, las interacciones y la información así como las intenciones de recomendar la organización, de adquirir sus productos y de iniciar acciones legales. En línea con lo hipotetizado, el resultado de la selección influye en las percepciones de justicia, en las intenciones respecto a la organización y en la intención de adquirir sus productos. Los resultados de las ecuaciones de regresión jerárquica muestran diferencias entre hombres y mujeres. A las mujeres les influye sobre todo la justicia en los procedimientos y a los hombres la justicia en las interacciones y en la información. Se discuten las implicaciones de los resultados para la investigación y la práctica profesional.

  7. Developing global capabilities for the observation and predication of harmful algal blooms

    CSIR Research Space (South Africa)

    Bernard, S

    2014-01-01

    Full Text Available ). The GEO Blue Planet HAB initiative seeks to consolidate and expand on existing capabilities, building a global community to develop and maximise the use and societal benefits of an integrated HAB observation and prediction system. Such a system would...

  8. PredicForex. A tool for a reliable market. Playing with currencies.

    Directory of Open Access Journals (Sweden)

    C. Cortés Velasco

    2009-12-01

    Full Text Available The Forex market is a very interesting market. Finding a suitable tool to forecast currency behavior will be of great interest. It is almost impossible to find a 100 % reliable tool. This market is like any other one, unpredictable. However we developed a very interesting tool that makes use of WebCrawler, data mining and web services to offer and forecast an advice to any user or broker.

  9. Predications and Observations of Global Beta-induced Alfven-acoustic Modes in JET and NSTX

    International Nuclear Information System (INIS)

    Gorelenkov, N.N.

    2008-01-01

    In this paper we report on observations and interpretations of a new class of global MHD eigenmode solutions arising in gaps in the low frequency Alfven-acoustic continuum below the geodesic acoustic mode frequency. These modes have been just reported (Gorelenkov et al 2007 Phys. Lett. 370 70-7) where preliminary comparisons indicate qualitative agreement between theory and experiment. Here we show a more quantitative comparison emphasizing recent NSTX experiments on the observations of the global eigenmodes, referred to as beta-induced Alfven-acoustic eigenmodes (BAAEs), which exist near the extrema of the Alfven-acoustic continuum. In accordance to the linear dispersion relations, the frequency of these modes may shift as the safety factor, q, profile relaxes. We show that BAAEs can be responsible for observations in JET plasmas at relatively low beta 20%. In NSTX plasma observed magnetic activity has the same properties as predicted by theory for the mode structure and the frequency. Found numerically in NOVA simulations BAAEs are used to explain the observed properties of relatively low frequency experimental signals seen in NSTX and JET tokamaks

  10. On the Nature of Syntactic Variation: Evidence from Complex Predicates and Complex Word-Formation.

    Science.gov (United States)

    Snyder, William

    2001-01-01

    Provides evidence from child language acquisition and comparative syntax for existence of a syntactic parameter in the classical sense of Chomsky (1981), with simultaneous effects on syntactic argument structure. Implications are that syntax is subject to points of substantive parametric variation as envisioned in Chomsky, and the time course of…

  11. Subjective and objective assessment of patients' compression therapy skills as a predicator of ulcer recurrence.

    Science.gov (United States)

    Mościcka, Paulina; Szewczyk, Maria T; Jawień, Arkadiusz; Cierzniakowska, Katarzyna; Cwajda-Białasik, Justyna

    2016-07-01

    To verify whether the subjectively and objectively assessed patient's skills in applying compression therapy constitute a predicting factor of venous ulcer recurrence. Systematic implementation of compression therapy by the patient is a core of prophylaxis for recurrent ulcers. Therefore, patient education constitutes a significant element of care. However, controversies remain if all individuals benefit equally from education. A retrospective analysis. The study included medical records of patients with venous ulcers (n = 351) treated between 2001 and 2011 at the Clinic for Chronic Wounds at Bydgoszcz Clinical Hospital. We compared two groups of patients, (1) with at least one episode of recurrent ulcer during the five-year observation period, and (2) without recurrences throughout the analysed period in terms of their theoretical skills and knowledge on compression therapy recorded at baseline and after one month. Very good self-assessment of a patient's compression therapy skills and weak assessment of these skills by a nurse proved significant risk factors for recurrence of the ulcers on univariate analysis. The significance of these variables as independent risk factors for recurrent ulcers has been also confirmed on multivariate analysis, which also took into account other clinical parameters. Building up proper compression therapy skills among the patients should be the key element of a properly construed nurse-based prophylactic program, as it is the most significant modifiable risk factor for recurrent ulcers. Although the development of compression skills is undeniably important, also other factors should be considered, e.g. surgical correction of superficial reflux. Instruction on compression therapy should be conducted by properly trained nursing personnel - the nurses should have received both content and psychological training. The compression therapy training should contain practical instruction with guided exercises and in-depth objective assessment of the effects of the training. © 2016 John Wiley & Sons Ltd.

  12. Nomogram Method as Means for Resource Potential Efficiency Predicative Aid of Petrothermal Energy

    Science.gov (United States)

    Gabdrakhmanova, K. F.; Izmailova, G. R.; Larin, P. A.; Vasilyeva, E. R.; Madjidov, M. A.; Marupov, S. R.

    2018-05-01

    The article describes the innovative approach when predicting the resource potential efficiency of petrothermal energy. Various geothermal gradients representative of Bashkortostan and Tatarstan republics regions were considered. With the help of nomograms, the authors analysed fluid temperature dependency graphs at the outlet and the thermal power versus fluid velocity along the wellbore. From the family of graphs plotted by us, velocities corresponding to specific temperature were found. Then, according to thermal power versus velocity curve, power levels corresponding to these velocities relative to the selected fluid temperature were found. On the basis of two dependencies obtained, nomograms were plotted. The result of determining the petrothermal energy production efficiency is a family of isocline lines that enables one to select the optimum temperature and injection rate to obtain the required amount of heat for a particular depth and geothermal gradient.

  13. Application of a Patient Derived Xenograft Model for Predicative Study of Uterine Fibroid Disease.

    Directory of Open Access Journals (Sweden)

    Martin Fritsch

    Full Text Available Human uterine fibroids, benign tumors derived from the smooth muscle layers of the uterus, impose a major health burden to up to 50% of premenopausal women in their daily life. To improve our understanding of this disease, we developed and characterized a patient-derived xenograft model by subcutaneous transplantation of pieces of human uterine fibroid tissue into three different strains of severe combined immunodeficient mice. Engrafted uterine fibroid tissue preserved the classical morphology with interwoven bundles of smooth muscle cells and an abundant deposition of collagenous matrix, similar to uterine fibroids in situ. The grafts expressed both estrogen receptor 1 and progesterone receptor. Additionally, both receptors were up-regulated by estrogen treatment. Growth of the fibroid grafts was dependent on 17β-estradiol and progesterone supplementation at levels similar to women with the disease and was studied for up to 60 days at maximum. Co-treatment with the antiprogestin mifepristone reduced graft growth (four independent donors, p<0.0001 two-sided t-test, as did treatment with the mTOR inhibitor rapamycin (three independent donors, p<0.0001 two-sided t-test. This in vivo animal model preserves the main histological and functional characteristics of human uterine fibroids, is amenable to intervention by pharmacological treatment, and can thus serve as an adequate model for the development of novel therapies.

  14. Suppression of TIM-1 predicates clinical efficacy of sublingual immunotherapy for allergic rhinitis in children.

    Science.gov (United States)

    Lin, Zhibin; Zhou, Lifeng; Luo, Xi; Xia, Wentong; Chen, Dehua; Xu, Rui; Wang, Jie; Luo, Renzhong; Xu, Geng; Li, Huabin

    2013-08-01

    To evaluate the clinical efficacy of sublingual immunotherapy (SLIT) with house-dust mite (HDM) extract and to examine the change of biomarkers (TIM-1, IL-5 and IL-10) after 6-month SLIT in children with allergic rhinitis (AR). One hundred and sixteen HDM-sensitized children with persistent AR were enrolled to assess the clinical efficacy of SLIT by determining the individual nasal symptom score (INSS) and total nasal symptom scores (TNSS) after 6-month SLIT. Moreover, the mRNA expression of TIM-1, IL-5 and IL-10 in peripheral blood mononuclear cells (PBMCs) was examined in 16 well-controlled and 12 uncontrolled AR patients using quantitative reverse transcription polymerase chain reaction (qRT-PCR). After 6-month SLIT, both TNSS and INSS scores were significantly decreased compared with the baseline value (p < 0.01). The rates for well-controlled, partly controlled and uncontrolled children were 43.1%, 32.8% and 24.1%, respectively. Accordingly, the mRNA levels of TIM-1 and IL-5 decreased significantly and IL-10 mRNA level increased significantly compared with the baseline value in well-controlled children (p < 0.05). Our findings suggest SLIT with HDM extract is effective and safe for AR children and TIM-1 may be considered as an indicator for evaluating the clinical efficacy of SLIT. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  15. Disaster Coverage Predication for the Emerging Tethered Balloon Technology: Capability for Preparedness, Detection, Mitigation, and Response.

    Science.gov (United States)

    Alsamhi, Saeed H; Samar Ansari, Mohd; Rajput, Navin S

    2018-04-01

    A disaster is a consequence of natural hazards and terrorist acts, which have significant potential to disrupt the entire wireless communication infrastructure. Therefore, the essential rescue squads and recovery operations during a catastrophic event will be severely debilitated. To provide efficient communication services, and to reduce casualty mortality and morbidity during the catastrophic events, we proposed the Tethered Balloon technology for disaster preparedness, detection, mitigation, and recovery assessment. The proposed Tethered Balloon is applicable to any type of disaster except for storms. The Tethered Balloon is being actively researched and developed as a simple solution to improve the performance of rescues, facilities, and services of emergency medical communication in the disaster area. The most important requirement for rescue and relief teams during or after the disaster is a high quality of service of delivery communication services to save people's lives. Using our proposed technology, we report that the Tethered Balloon has a large disaster coverage area. Therefore, the rescue and research teams are given higher priority, and their performance significantly improved in the particular coverage area. Tethered Balloon features made it suitable for disaster preparedness, mitigation, and recovery. The performance of rescue and relief teams was effective and efficient before and after the disaster as well as can be continued to coordinate the relief teams until disaster recovery. (Disaster Med Public Health Preparedness. 2018;12:222-231).

  16. Predicate Matching in NLP: A Review of Research on the Preferred Representational System.

    Science.gov (United States)

    Sharpley, Christopher F.

    1984-01-01

    Reviews 15 studies that have investigated the use of the Preferred Representational System (PRS) in Neurolinguistic Programming (NLP). Aspects of design, methodology, population and dependent measures are evaluated, with comments on the outcomes obtained. Results suggested that there is little supportive evidence for the use of PRS in the NLP.…

  17. Pharmacological and Behavioral Enhancement of Neuroplasticity in the MPTP-Lesioned Mouse and Nonhuman Primate

    Science.gov (United States)

    2009-05-01

    in the clinical rating of these animals. In addition, hypo - kinesia or a general poverty of movement of an ani- mal in its environment is another...Supportive intervention to avoid this adverse effect includes feeding lesioned non-human primates by gavage with an enriched diet , injection of subcu...weight and white blood cell count were the key predic- tors of mortality and should be monitored during MPTP administration. Supplemental caloric

  18. Epidemiological and ecological aspects related to malaria in the area of influence of the lake at Porto Primavera dam, in western São Paulo State, Brazil Aspectos epidemiológicos e ecológicos relacionados à malária na área de influência do lago da Represa de Porto Primavera, região oeste do Estado de São Paulo, Brasil

    Directory of Open Access Journals (Sweden)

    Almério de C. Gomes

    2008-10-01

    this paper.Foi realizada pesquisa na área de influência do lago da Usina Hidrelétrica de Porto Primavera, região oeste do Estado de São Paulo, para estudar aspectos ecológicos e epidemiológicos da malária na localidade e acompanhar o perfil das populações de anofelinos frente às mudanças decorrentes do impacto ambiental pela formação do lago. Mosquitos capturados foram analisados pelo Índice de Abundância de Espécies Padronizado (IAEP, antes e durante o enchimento do reservatório (cotas 253 e 257 m. A população humana local foi estudada por meio de teste parasitológico (gota espessa e esfregaço sangüíneo, testes moleculares (PCR e testes sorológicos. A sorologia consistiu na reação de ELISA com peptídeos sintéticos correspondentes à porção repetitiva da proteína circumsporozoíta (CSP de Plasmodium vivax clássico, e suas variantes VK247 e "vivax-like", P. malariae e P. falciparum; e reação de Imunofluorescência Indireta (RIFI com formas assexuadas de P. vivax, P. malariae e P. falciparum. Os resultados do estudo entomológico indicaram que, embora a população de Anopheles darlingi tenha aumentando após o enchimento, permaneceu em baixa densidade. Não foi detectada malária nem a presença de parasitos ou de DNA parasitário nos habitantes estudados. No entanto, foi observada baixa freqüência de anticorpos contra formas assexuadas e significativa prevalência de anticorpos contra esporozoítos de P. vivax e suas variantes, P. falciparum e P. malariae, que poderiam decorrer de contatos prévios, recentes ou não, com plasmódios humanos ou símios (o ciclo silvestre foi evidenciado em estudo paralelo realizado na mesma área. Por outro lado, estes resultados sugerem que, como em outros lugares onde existem vetores potenciais da malária, as condições epidemiológicas poderiam potencialmente permitir a transmissão da malária na área de influência do lago de Porto Primavera, se indivíduos infectados fossem introduzidos em n

  19. Colonização micorrízica arbuscular e tolerância ao mal-do-Panamá em mudas de banana-maçã Colonisation of arbuscular mycorrhiza and tolerance to Panama disease in seedlings of the maçã banana

    Directory of Open Access Journals (Sweden)

    Deusiane Batista Sampaio

    2012-09-01

    Full Text Available O objetivo desse trabalho foi avaliar o efeito da colonização micorrízica arbuscular na tolerância da bananeira, cv. Maçã, ao mal-do-Panamá, sob diferentes fontes de nutrientes. Utilizou-se um delineamento inteiramente casualizado com fatorial 2 x 4 [2 densidades de esporos de FMA nativos (D1 - 3.500 esporos kg-1 solo e D2 - 7.000 esporos kg-1 solo e 4 diferentes concentrações de fontes de nutrientes - três de solução nutritiva (SN 40%, SN 70% e SN 100% e uma de biofertilizante 100% (B4] com três repetições. Após o plantio inoculou-se Fusarium oxysporum f.sp. cubense e posteriormente avaliou-se matéria seca da parte aérea (MSPA, o teor de fósforo foliar (P, a colonização micorrízica, o pH do solo e o índice de severidade da doença (ID. As diferentes fontes de nutrientes influenciaram a matéria seca da parte aérea, o teor de fósforo, a colonização micorrízica e o índice de severidade da doença, porém não influenciaram o pH da solução do solo. O biofertilizante não atendeu à demanda nutricional das plantas, as quais se mostraram pouco desenvolvidas. Porém proporcionou intensa colonização micorrízica e menor índice de severidade da fusariose, o qual aumentou com a adubação mineral.The aim of this study was to evaluate the effect of the colonization of arbuscular mycorrhiza on the tolerance to Panama disease of the banana plant cv. maçã under different sources of nutrients. A completely randomized design was employed, having a 2 x 4 factorial [2 densities of native FMA spores (D1 - 3,500 spores kg-1 soil and D2 - 7000 spores kg-1 soil and four different concentrations of nutrient sources - three of a nutrient solution (SN 40%, SN 70% and SN 100% and a 100% solution of bio-fertiliser (B4], with three replications. After planting, the seedlings were inoculated with Fusarium oxysporum f.sp. cubense, and later the shoot dry matter, leaf phosphorus content, mycorrhizal colonization, soil pH and disease

  20. Kıbrıs Mülkiyet Tartışmasına Taşınmaz Mal Komisyonu Açısından Bir Bakış Cyprus Property Dispute through the Glance of Immovable Property Commission

    Directory of Open Access Journals (Sweden)

    Derya ÖZVERİ

    2013-07-01

    erçevesindetanımlamak amaçlanmaktadır. Ardından Kıbrıs’ta Türk ve Yunantarafların mülkiyet tartışmasına bakış açılarını da ele alınacaktır. İkitarafında müzakare masasında çok esneme payı bırakmadıkları bubakış açıları birbirinden çok farklı bir yapı da olması, uzlaşınınoluşabilmesini olanaksızlaştırdığından bu argümanlar daha da önemkazanmaktadır. Anlaşmazlığın taraflardan biri olan Türk tarafi ikibölgelilik,Yunan tarafı ise insan hakları argümanları üzerinden konuyayaklaşmaktadır. Taraflar tezlerini bu yönde savunurken, bu çalışmaAvrupa Insan Haklari Mahkemesi´nin iki önemli karari ile (LoizidouTürkiye´ye Karşı ve Xenides-Arestis Türkiye‘ye Karsi kurulmasinasebebiyet verdiği ve kararları ile bir iç hukuk yontemi olaraktüketilmesini ön-kosul olarak gösterdiği Tasinmaz Mal Komisyonu´nuincelemeye çalışacak ve artık görüşme masasında kemikleşmiş bir konuhaline gelmiş, adanın mülkiyet sorununa yeni bir umut ışığıolabileceğini tartışmayı amaçlamaktadır.

  1. Entrevistando as famílias de recém-nascidos mal-formados como proposta de avaliação e de intervenção de enfermagem - DOI: 10.4025/actascihealthsci.v26i1.1646 Interviewing the families of sick newborn babies as a proposal of - DOI: 10.4025/actascihealthsci.v26i1.1646

    Directory of Open Access Journals (Sweden)

    Dirce Laplaca Viana

    2004-04-01

    Full Text Available Trata-se de um estudo que buscou meios para entender como lidar com a família que vivenciou a notícia de ter um recém-nascido mal-formado. A entrevista ocorreu em um hospital público de São Paulo, em novembro de 2002, utilizando-se o Modelo Calgary de Avaliação e Intervenção na Família (MCAF/MCIF. O estudo mostrou a necessidade de intervenções construídas com a família para minimizar o impacto da notícia e para favorecer espaço para expressão de sentimentos e resolução da crise. O papel do enfermeiro como membro da equipe interdisciplinar é tentar efetivar o trabalho de ajuda à família de forma precoce, quando esta vive a difícil experiência de ter uma criança especial. A intervenção visa atuar com a família a partir da detecção do problema, utilizando a escuta ativa da comunicação verbal e não-verbal na tentativa de compreensão da situação e atuar como facilitador do processo de resolutividade da crise vivenciada.This paper is based on a study that searched ways to understand how to deal with the family who experienced the news of a sick newborn. The interview was performed in a hospital located in São Paulo, Brazil, in November of 2002 and it used the Calgary Model of Assessment and Intervention in Family (CMAF/CMIF. This study showed the need for intervention with the family to minimize the impact of receiving the news of a sick newborn, and to provide support through a conversation for resolution of the problem. The function of the nurse is to try to perform a precocious work with the family, facing the difficult experience of having a special child. The intervention aims to help the family to solve the problem, listening to the verbal and not verbal communication, searching to understand the situation with the family.

  2. Amaç ve Beklenti Karşısında Karşılaştırmalı Edebiyatın Tanı(MSal Krizine İlişkin Birtakım Tartışmalı Saptamalar Some Argumentative Determinations Regarding Diagnostic/Definitional Crisis Of Comparative Literature In Terms Of Accordance With Its Purpose And Expectation

    Directory of Open Access Journals (Sweden)

    Abdulhakim TUĞLUK

    2013-09-01

    Full Text Available Comparison which possesses the characteristics of critic in linewith its purposes and ambitions keeps on its actuality and differenceperception because of its argumentative position within the science ofliterature. “Comparative Literature Science” which has become effectivein literature argumentations in recent years in Turkey has not beenable to make its identity and conceptual entity acceptable, yet. Not onlythe uncertainties in the definition, but also some problems in practicekeep the questions against comparative literature in a certain level.There are also some uncertainties whether it is a method or a science initself as well as the acceptability of it by national men of literature.Comparison, which is seen as easy to do at first in terms of feasibility,shows itself as a complex process when the literal and aestheticmissions attributed by the concept to it are taken into consideration.This complexity becomes a crisis in which there are many questionswhen it is faced with diagnostic and definitive problems. On the otherhand, West-centered perception of the comparative literature and itsinternational face embracing the concept of „world literature‟(Weltliteratur make global scale expectations committed by the conceptmore argumentative rather than meeting these expectations. In thisstudy, the main starting point is gaining a certain point of view to theidentity confusion of comparative literature and establishing a generalargumentation basis. The purpose of this study is revealing somecomplex points in theory and practice considering existential problemsof comparative literature and bringing some expansion to somehandicaps regarding essence of the comparative literature. Amaç ve hedefleri doğrultusunda bir eleştiri türü niteliği taşıyan karşılaştırma, edebiyat bilimi içerisindeki tartışmalı konumu nedeniyle güncelliğini ve farklılık algısını sürdürmektedir. Türkiye‟de, son yıllarda, edebi tart

  3. Uma revisão sobre depressão como fator de risco na Doença de Parkinson e seu impacto na cognição Revisión sobre la depressión como factor de riesgo en el Mal de Parkinson e impacto sobre la cognición A review of depression as a risk factor in Parkinson's disease and the impact on cognition

    Directory of Open Access Journals (Sweden)

    Cláudia Débora Silberman

    2004-04-01

    utilizem critérios diagnósticos definidos e com amostras representativas da população podem trazer esclarecimento sobre o assunto.OBJETIVOS: Este trabajo tiene dos objetivos: 1 Examinar el impacto de la depresión sobre la cognición en el Mal de Parkinson (MP. 2 Examinar el papel de la depresión como factor de riesgo tanto para el MP como para trastorno cognoscitivo en el MP. METODOLOGÍA: Revisión de la literatura internacional (Medline, de artículos clínicos, seccionales, prospectivos y de caso control evaluando la función cognoscitiva de Parkinsonianos con y sin depresión, entre 1967 y 2003. Palabras clave: Mal de Parkinson, Depresión y Cognición. RESULTADOS: Los trabajos sobre el impacto de la depresión en la cognición de parkinsonianos presentan afirmaciones divergentes. Cinco artículos concluyen que hay impacto e cuatro no confirman esos datos. Puede afirmarse que la depresión es un factor de riesgos para MP así como el MP es un factor de riesgo para la depresión. No en tanto, ninguna definición fue posible en lo que se refiere a la depresión como factor de riesgo para trastornos cognoscitivos en parkinsonianos. Se observa que los datos sobre a prevalencia de la depresión y déficit cognoscitivo en el MP son inconclusivos con grande margen porcentual entre los autores. La depresión en parkinsonianos está asociada con el avance de la gravedad del MP, estado avanzado de Hoehn y Yahr, puntuación alta en la Unified Parkinson's Disease Rating Scale (UPDRS ocurrencia de caídas, baja puntuación en el Mini Examen del Estado Mental (MEEM y en la escala de Schwab y England, déficit cognoscitivo, bradykinesia axial, alteraciones en el caminar y en el balance, edad más avanzada, sexo femenino y presencia de alteración del pensamiento. CONCLUSIÓN: La interacción entre la depresión y MP es compleja y bi-direccional. La depresión es un factor de riesgo para MP así como MP es un factor de riesgo para la depresión. Es imposible trazar un perfil mas

  4. Right ventricular dysfunction following continuous flow left ventriccular assist device placement in 51 patients: predicators and outcomes

    Directory of Open Access Journals (Sweden)

    Neragi-Miandoab Siyamek

    2012-06-01

    Full Text Available Abstract Background Right ventricular (RV dysfunction following implantation of a left ventricular assist device (LVAD is a serious condition and is associated with increased mortality. Methods The aim of the study is to investigate the significance of pre-existing RV dysfunction, tricuspid valve (TV insufficiency, and the severity of septal deviation following LVAD implantation on RV dysfunction, as well as the outcome and short-term complications in 51 patients from June 2006 to August 2010. Student t test was used to compare the data and estimate the p value. Results Mean age was 55.1 ± 13, with a male to female ratio of 3.25. The 30-day mortality was 13.7% (7/51 patients, and the overall mortality was 23.5% (12/51 patients. Meanwhile, 21 patients (21/51; 41.2% have undergone orthotopic heart transplantation. The mean time of support was 314.5±235 days with a median of 240 days at the time of closing this study. Echocardiographic evaluation of RV function pre- and post-implantation of an LVAD demonstrated septal deviation towards the left ventricle in immediate postoperative phase, which correlated with acute RV dysfunction (p = 0.002. Preoperative RV dysfunction was a significant predictor of postoperative right heart dysfunction following implantation of an LVAD (p = 0.001. Conclusion Preoperative RV dysfunction is a predictor of RV failure in LVAD patients. The adjustment of septal deviation through gradual increase of the LVAD flow can prevent the acute RV dysfunction following LVAD placement.

  5. Marital Stress and Extraversion Personality as Predicators of Job Satisfaction among Married Women Teachers in Enugu, Nigeria

    Science.gov (United States)

    Elom, Sampson Omena; Egba, Nwamaka A.

    2015-01-01

    The study investigated marital stress and extraversion personality as predictors of job satisfaction among married women teachers in Enugu, Nigeria. One hundred and eighty eight married women teachers in Enugu, Nigeria participated in the study. Three instruments were used to gather information in this study. They included marital stress inventory…

  6. Synthesis, PASS-Predication and in Vitro Antimicrobial Activity of Benzyl 4-O-benzoyl-α-l-rhamnopyranoside Derivatives

    Directory of Open Access Journals (Sweden)

    Mohammed Mahbubul Matin

    2016-08-01

    Full Text Available Benzyl α-l-rhamnopyranoside 4, obtained by both conventional and microwave assisted glycosidation techniques, was subjected to 2,3-O-isopropylidene protection to yield compound 5 which on benzoylation and subsequent deprotection of isopropylidene group gave the desired 4-O-benzoylrhamnopyranoside 7 in reasonable yield. Di-O-acetyl derivative of benzoate 7 was prepared to get newer rhamnopyranoside. The structure activity relationship (SAR of the designed compounds was performed along with the prediction of activity spectra for substances (PASS training set. Experimental studies based on antimicrobial activities verified the predictions obtained by the PASS software. Protected rhamnopyranosides 5 and 6 exhibited slight distortion from regular 1C4 conformation, probably due to the fusion of pyranose and isopropylidene ring. Synthesized rhamnopyranosides 4–8 were employed as test chemicals for in vitro antimicrobial evaluation against eight human pathogenic bacteria and two fungi. Antimicrobial and SAR study showed that the rhamnopyranosides were prone against fungal organisms as compared to that of the bacterial pathogens. Interestingly, PASS prediction of the rhamnopyranoside derivatives 4–8 were 0.49 < Pa < 0.60 (where Pa is probability ‘to be active’ as antibacterial and 0.65 < Pa < 0.73 as antifungal activities, which showed significant agreement with experimental data, suggesting rhamnopyranoside derivatives 4–8 were more active against pathogenic fungi as compared to human pathogenic bacteria thus, there is a more than 50% chance that the rhamnopyranoside derivative structures 4–8 have not been reported with antimicrobial activity, making it a possible valuable lead compound.

  7. PREDICATIVE VALUE OF SOME COMMON MOBILITY TESTS CRUCIAL FOR FORMING MARK IN THE PHYiCAL EDUCATION TEACHING

    Directory of Open Access Journals (Sweden)

    Danijela Bulatović

    2007-05-01

    Full Text Available Up to the sam ple of 86 stu dents from 5th class of Ele men tary School »Ok to ih« in Pod go ri ca, we ma de re se arch in or der to esta blish the le vel of sta ti sti cal im por tan ce of the com mon mo bi lity tests in fl u en ce for for ming of the physi cal edu ca tion mark. By using of Pir son cor re la ti ve analysis, fol lo wed by the re gres si ve analysis, it was esta blis hed the im por tant mu tual con nec tion bet we en pre di ca ti ve and cri te rion va ri a ble. The co ef fi ci ent of cor re la tion has been spread from the mid dle (MT600= . 488, to the high nu me ri cal va lu es (MSDM =. 735.

  8. Quantitative thermodynamic predication of interactions between nucleic acid and non-nucleic acid species using Microsoft excel.

    Science.gov (United States)

    Zou, Jiaqi; Li, Na

    2013-09-01

    Proper design of nucleic acid sequences is crucial for many applications. We have previously established a thermodynamics-based quantitative model to help design aptamer-based nucleic acid probes by predicting equilibrium concentrations of all interacting species. To facilitate customization of this thermodynamic model for different applications, here we present a generic and easy-to-use platform to implement the algorithm of the model with Microsoft(®) Excel formulas and VBA (Visual Basic for Applications) macros. Two Excel spreadsheets have been developed: one for the applications involving only nucleic acid species, the other for the applications involving both nucleic acid and non-nucleic acid species. The spreadsheets take the nucleic acid sequences and the initial concentrations of all species as input, guide the user to retrieve the necessary thermodynamic constants, and finally calculate equilibrium concentrations for all species in various bound and unbound conformations. The validity of both spreadsheets has been verified by comparing the modeling results with the experimental results on nucleic acid sequences reported in the literature. This Excel-based platform described here will allow biomedical researchers to rationalize the sequence design of nucleic acid probes using the thermodynamics-based modeling even without relevant theoretical and computational skills. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  9. Mal du siècle et mal du lieu : bovarysme et romantisme mêlés dans les deux grands romans modernes de Flaubert

    Directory of Open Access Journals (Sweden)

    Philippe Chardin

    2010-01-01

    Full Text Available Cet article tente, à partir d’une comparaison d’ensemble entre les deux grands romans modernes de Flaubert, Madame Bovary et L’Éducation sentimentale, et d’une superposition d’exemples significatifs empruntés à chacun d’eux, de montrer que la série des contrastes qui viennent tout de suite à l’esprit ne doit pas dissimuler des variations subtiles autour des mêmes schémas narratifs et des mêmes paysages psychiques : aussi bien pour ce qui est du pôle négatif des ridicules (« bovarysme » impénitent de Frédéric et des infortunes (analogies entre les épreuves traversées, notamment en matière d’« éducation sentimentale » que pour ce qui est du pôle du positif — plus implicite chez Flaubert — incluant une sorte de principe de réhabilitation partielle des « premiers plans » et la permanence de tout un romantisme de la singularité, de la révolte, de l’élection par le malheur, de la passion, du désir.With a global comparison between Flaubert’s two chief modern novels, Madame Bovary and L’Éducation sentimentale, and a superposition of suggestive examples taken from both of them, this article intends to prove that the sequence of contrasts that firstly appear must not conceal the subtle variations on the same narrative patterns and the same psychological climates. We can notice this phenomena as well as for the negative poles of ridiculous features (Frederic’s impenitent “bovarysme” and misfortunes (analogies between the trials that have to be faced by the heroes — especially those of the “sentimental journey”, as for the positive pole — more implicit in Flaubert’s prose — that implies a kind of partial rehabilitation principle of the main characters, and the persistence of romanticism, a whole romanticism with singularity, revolt, election through unhappiness,  passion and desire.

  10. Jeanne and Charles : Les Fleurs du Mal as ‘Uncertain Fables’

    NARCIS (Netherlands)

    Rosello, M.

    2017-01-01

    This article explores the constantly evolving status of “Jeanne Duval” within the various discourses that constitute French studies. Travelling back and forth between invisibility and hyper-visibility, legibility and opacity, at times relegated to the margins of Baudelaire’s poetry, and sometimes

  11. 2558-IJBCS-Article-Amadou Malé Kouyaté

    African Journals Online (AJOL)

    admin

    The native oil tree species: a useful resource for local communities in southern Mali ... understand the uses of oil trees species according to the ethnic group, village, age and gender. Semi- ..... among parkland agroforests in eastern. Niger. ... for the benefit of the poor, Washington,. USA. ... India's Dry Deciduous Forest.

  12. Local perceptions of climate change impacts and migration patterns in Malé, Maldives

    Czech Academy of Sciences Publication Activity Database

    Stojanov, R.; Duží, Barbora; Kelman, I.; Němec, D.; Procházka, D.

    2017-01-01

    Roč. 183, č. 4 (2017), s. 370-385 ISSN 0016-7398 Institutional support: RVO:68145535 Keywords : Maldives * climate change impacts * migration * risk management * quantitative survey Subject RIV: DE - Earth Magnetism, Geodesy, Geography OBOR OECD: Cultural and economic geography Impact factor: 3.132, year: 2016 http://onlinelibrary.wiley.com/doi/10.1111/geoj.12177/abstract

  13. Assessment of Evapotranspiration Simulation in the Malše Basin

    Czech Academy of Sciences Publication Activity Database

    Košková, Romana; Němečková, Soňa

    2009-01-01

    Roč. 4, Sp. Iss. 2 (2009), s. 111-122 ISSN 1801-5395 R&D Projects: GA AV ČR(CZ) KJB300600602 Institutional research plan: CEZ:AV0Z20600510 Keywords : hydrological modelling * evapotranspiration * SWIM model Subject RIV: DA - Hydrology ; Limnology

  14. Adaptace pracovníků v malé organizaci

    OpenAIRE

    Štěpánová, Berta

    2012-01-01

    Dissertation deals with an analysis of an adaptation process in a small organization. It handles placing of the adaptation process into a context of human resources activities. Individual areas of the adaptation are specified - working adaptation, social adaptation and adaptation to a company culture. Also aims of the adaptation, factors influencing the process of adaptation in the company, planning and management of the adaptation are specified. The process of adaptation, elements and tools ...

  15. Effect of refrigerant mal-distribution in fin-and-tube evaporators on system performance

    DEFF Research Database (Denmark)

    Kærn, Martin Ryhl; Elmegaard, Brian; Larsen, Lars Finn Sloth

    2009-01-01

    the condenser is a dynamic moving boundary model. The evaporator model is a dynamic distributed one-dimensional homogeneous equilibrium model, in order to capture the distribution phenomena. Fin-and-tube heat exchangers usually have a complex circuitry, however the evaporator will be simplified to be two...

  16. Fugacities and Inanities in Malú Urreola’s "Nada" y "Bracea".

    Directory of Open Access Journals (Sweden)

    Gonzalo Ignacio Rojas

    2017-07-01

    Full Text Available This paper aims to analyze the last two textbooks from Malu Urriola: Nada y Bracea, which are part of a trilogy to be constructed. For this purpose, we reviewed both theoretical and anchor text from the rhizome (Deleuze and Guattari and the concept of differance (Derrida to see the poetic discourse as an agent for representation of the poetic word in another, besides the Blend aesthetic notions as the perky, rebound, transience and intermediate. These anchorages and mixtures are placed in tension in this trilogy to be done and thus respond to the crossing that occur in these textbooks between poetic expression and its inanity as representing the speaking being.

  17. Genómica del Trypanosoma cruzi. Nuevas oportunidades para tratar el mal de Chagas

    Directory of Open Access Journals (Sweden)

    Jorge A. Huete-Pérez

    2006-12-01

    Full Text Available LA SECUENCIACIÓN DEL GENOMA HUMANO PUBLICADA EN FEBRERO de 2001 ha sido considerada como el hito científico más importante del siglo XX. La secuenciación, cuatro años más tarde, de tres parásitos tripanosmatidas, entre ellos el Trypanosoma cruzi, podría ser también catalogada como uno de los acontecimientos científicos más importantes para la salud publica del continente americano. Aquí se presenta un panorama general sobre los resultados más significativos del estudio geonómico del T. cruzi, se abordan los trabajos realizados por nuestro laboratorio en la Universidad Centroamericana, finalizando con una discusión sobre las perspectivas del uso de la genómica en Nicaragua.

  18. Studie proveditelnosti podnikání malé maloobchodní firmy

    OpenAIRE

    Drugda, Marek

    2009-01-01

    This thesis describes the individual aspects of retail entrepreneurship of a small enterprise using the knowledge of large retail entrepreneurs. It introduces the business strategy of a clothing retail shop in Prague with an innovative business model, evaluates the external environment of the enterprise and its influence on the industry, outlines the procedures for managing specific areas of the operation and evaluates the feasibility of the enterprise utilizing a break even analysis and a ca...

  19. MalWebID-Autodetection and Identification of Malicious Web Hosts Through Live Traffic Analysis

    Science.gov (United States)

    2013-03-01

    site (i.e., Porn , Rx/Pharmaceutical, illegal activity, etc.) – propagate or contain viruses, spyware, or other harmful programs, participate in spamming...abu- sive sites remain a constant problem. This thesis explores a technique to discern hosts that support abusive web infrastructure by discovering...in- clude, but is not limited to, web sites that cater to, sponsor, or actively participate in supporting various forms of malicious content. Thus

  20. Strategi Marketing Mix Baitul Mal Wa Tamwil (BMT) Unit Gabungan Terpadu (UGT) Sidogiri Pasuruan

    OpenAIRE

    Kirom, Cihwanul

    2016-01-01

    Within the business realm, marketing is a key factor which determines the success of distribution. Therefore, strategy and innovation are a necessity. Marketing activity would ensure whether a certain product is delivered to the costumers. In order to achieve the desired goals of marketing, it is important to manufacturers to follow a set of marketing processes, which comprise market overview, marketing strategy, marketing mix, and evaluation. Marketing mix is a set of strategies consist of p...

  1. Rozvoj kultury v malé obci Středočeského kraje

    Czech Academy of Sciences Publication Activity Database

    Vojtíšková, Kateřina

    2013-01-01

    Roč. 5, č. 2 (2013), s. 143-160 E-ISSN 1803-8220 R&D Projects: GA MK DF11P01OVV032 Keywords : local culture * regional development * citizen participation Subject RIV: AE - Management ; Administration http://acpo.vedeckecasopisy.cz/publicFiles/00462.pdf

  2. Ganándole la batalla al mal humor. Una propuesta didáctica

    Directory of Open Access Journals (Sweden)

    Sarah Díaz García

    2012-01-01

    Full Text Available En los últimos años, el aprendizaje de lenguas extranjeras ha llegado a ser una necesidad real tanto profesional como personal para todos nosotros como ciudadanos y como trabajadores. La enseñanza del español como lengua extranjera, que es el área de estudio en el que nos centraremos en el resto del presente artículo, ha evolucionado a medida que nuestra sociedad ha ido cambiando y adaptándose a los nuevos tiempos. Este cambio surgió con el Marco Común Europeo de Referencia para las Lenguas (MCER; pasamos de darle una máxima importancia a los aspectos puramente lingüísticos a abrirnos al hecho de que aprender un segundo idioma no es solo centrarnos en la gramática. La competencia comunicativa, por ejemplo, ha ido cobrando protagonismo en los últimos años; la idea de que un estudiante solo es competente en el uso de una lengua cuando utiliza la lingüística (pensemos en la gramática de forma correcta y siguiendo la norma ha caído en desaprobación para muchos. La realidad es que para que un alumno se considere competente en el uso de otra lengua que no sea la suya debe saber utilizar las técnicas y recursos pertinentes para poder comunicarse efectivamente con su interlocutor en un contexto real de habla.

  3. Ganándole la batalla al mal humor. Una propuesta didáctica

    Directory of Open Access Journals (Sweden)

    Sarah Díaz García

    2012-08-01

    Full Text Available En los últimos años, el aprendizaje de lenguas extranjeras ha llegado a ser una necesidad real tanto profesional como personal para todos nosotros como ciudadanos y como trabajadores. La enseñanza del español como lengua extranjera, que es el área de estudio en el que nos centraremos en el resto del presente artículo, ha evolucionado a medida que nuestra sociedad ha ido cambiando y adaptándose a los nuevos tiempos. Este cambio surgió con el Marco Común Europeo de Referencia para las Lenguas (MCER;[1] pasamos de darle una máxima importancia a los aspectos puramente lingüísticos a abrirnos al hecho de que aprender un segundo idioma no es solo centrarnos en la gramática. La competencia comunicativa, por ejemplo, ha ido cobrando protagonismo en los últimos años; la idea de que un estudiante solo es competente en el uso de una lengua cuando utiliza la lingüística (pensemos en la gramática de forma correcta y siguiendo la norma ha caído en desaprobación para muchos. La realidad es que para que un alumno se considere competente en el uso de otra lengua que no sea la suya debe saber utilizar las técnicas y recursos pertinentes para poder comunicarse efectivamente con su interlocutor en un contexto real de habla. [1] El Marco Común Europeo de Referencia para las Lenguas surgía en el año 2001. Desde entonces la enseñanza y el aprendizaje de lenguas extranjeras dio un cambio radical respecto a la metodología y la evaluación.

  4. ‘Copiar y pegar’ en investigaciones en el pregrado: haciendo mal uso del Internet

    Directory of Open Access Journals (Sweden)

    Charles Huamaní

    2008-06-01

    Full Text Available Introducción: La ética en el proceso de investigación es un tema poco abordado durante el pregrado, por lo que debe ser analizada para prevenir infracciones que podrían afectar el desarrollo de todo investigador en formación. Objetivo: Determinar las características de copia en los trabajos de investigación realizados durante el pregrado, por estudiantes de Medicina Humana de segundo año. Diseño: Estudio observacional retrospectivo. Lugar: Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Población: la sección de la ‘introducción’ de trabajos de investigación realizados el año 2004 en un curso curricular. Intervenciones: se revisó manualmente las oraciones de la ‘introducción’ de los trabajos, se describen el tipo de copia, el número de trabajos, autores, asesores, párrafos copiados, y el tipo de fuentes de información y de copia. Principales medidas de resultados: frecuencias y porcentajes de oraciones copiadas y tipo de copia. Resultados: Se revisó un total de 24 trabajos de investigación, con un promedio de 6 autores y 2 asesores por trabajo, 23 tenían alguna evidencia de copia electrónica, 8 sólo tenían copia literal; del total de oraciones evaluadas, el 64% corresponde a copia total de oraciones; sólo el 30% de las fuentes copiadas eran publicaciones científicas en línea, el resto son fuentes de acceso público no especializadas. Conclusiones: se describe una alta frecuencia de copia en investigaciones durante el pregrado provenientes de fuentes electrónicas, por lo que es necesario prevenir que se repita en futuras investigaciones al implementar sistemas de búsqueda sistemática de plagio.

  5. Metabolismo do ácido fólico na malária

    Directory of Open Access Journals (Sweden)

    Aymoré Vaz Pinto

    1983-06-01

    Full Text Available O estudo de 27 pacientes infectados pelo Plasmodium falciparum comparado com pessoas aparentemente sadias mostra: a diminuição do folato no soro dos pacientes infectados; b diminuição do folato sêrico nos primeiros 8 dias que seguiram ao tratamento, interpretados como sendo devido à mobilização pela eritropoiese compensadora; c folato eritrocítico normal.

  6. Rotavirus Infection and Disease in a Multisite Birth Cohort: Results From the MAL-ED Study.

    Science.gov (United States)

    Mohan, Venkata Raghava; Karthikeyan, Ramanujam; Babji, Sudhir; McGrath, Monica; Shrestha, Sanjaya; Shrestha, Jasmin; Mdumah, Estomih; Amour, Caroline; Samie, Amidou; Nyathi, Emanuel; Haque, Rashidul; Qureshi, Shahida; Yori, Pablo Peñataro; Lima, Aldo A M; Bodhidatta, Ladaporn; Svensen, Erling; Bessong, Pascal; Ahmed, Tahmeed; Seidman, Jessica C; Zaidi, Anita K M; Kosek, Margaret N; Guerrant, Richard L; Gratz, Jean; Platts-Mills, James A; Lang, Dennis R; Gottlieb, Michael; Houpt, Eric R; Kang, Gagandeep

    2017-08-01

    In a multicountry birth cohort study, we describe rotavirus infection in the first 2 years of life in sites with and without rotavirus vaccination programs. Children were recruited by 17 days of age and followed to 24 months with collection of monthly surveillance and diarrheal stools. Data on sociodemographics, feeding, and illness were collected at defined intervals. Stools were tested for rotavirus and sera for antirotavirus immunoglobulins by enzyme immunoassays. A total of 1737 children contributed 22646 surveillance and 7440 diarrheal specimens. Overall, rotavirus was detected in 5.5% (408/7440) of diarrheal stools, and 344 (19.8%) children ever had rotavirus gastroenteritis. Household overcrowding and a high pathogen load were consistent risk factors for infection and disease. Three prior infections conferred 74% (P < .001) protection against subsequent infection in sites not using vaccine. In Peru, incidence of rotavirus disease was relatively higher during the second year of life despite high vaccination coverage. Rotavirus infection and disease were common, but with significant heterogeneity by site. Protection by vaccination may not be sustained in the second year of life in settings with high burdens of transmission and poor response to oral vaccines. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

  7. Mal-Netminer: Malware Classification Approach Based on Social Network Analysis of System Call Graph

    Directory of Open Access Journals (Sweden)

    Jae-wook Jang

    2015-01-01

    Full Text Available As the security landscape evolves over time, where thousands of species of malicious codes are seen every day, antivirus vendors strive to detect and classify malware families for efficient and effective responses against malware campaigns. To enrich this effort and by capitalizing on ideas from the social network analysis domain, we build a tool that can help classify malware families using features driven from the graph structure of their system calls. To achieve that, we first construct a system call graph that consists of system calls found in the execution of the individual malware families. To explore distinguishing features of various malware species, we study social network properties as applied to the call graph, including the degree distribution, degree centrality, average distance, clustering coefficient, network density, and component ratio. We utilize features driven from those properties to build a classifier for malware families. Our experimental results show that “influence-based” graph metrics such as the degree centrality are effective for classifying malware, whereas the general structural metrics of malware are less effective for classifying malware. Our experiments demonstrate that the proposed system performs well in detecting and classifying malware families within each malware class with accuracy greater than 96%.

  8. Motivace pracovníků v malém podniku

    OpenAIRE

    Charvátová, Soňa

    2010-01-01

    This thesis is concerned with motivation and satisfaction of employees of one company in Prague. The theory is mainly focused on the explanation of motivation and stimulation, labour motivation and employee benefits. The point of the practical part is an analysis of the motivation system and employee satisfaction in the company. The resulting information is explicated. For the parts with the worst findings, some recommendations for improving the present motivation system are suggested.

  9. PERAN BAITUL MAL WAT TAMWIL UNTUK PEMULIHAN EKONOMI NASABAH KORBAN GEMPA DI GANTIWARNO KLATEN

    Directory of Open Access Journals (Sweden)

    Muhammad Sholahuddin

    2011-12-01

    Full Text Available The aims of this research are to get a clear description about the role, supporting factors and constraint factors of BMT “Surya” toward a societies empowerment in the agriculture sector in Klaten. Related with the aims of the research, therefore this this case study used qualitative research. Method of collecting the data used In Deep Interview throught three ways, those are observating, interviewing and documentating. Technique of analizing the data used Miles-Huberman.  The result of this research are: (1 The role of Baitul Maal Wat Tamwil (BMT “Surya” is empowerment of realized through services product by BMT “Surya” those are: (a loan of agriculture sector (b loan of livestock sector (c loan of service sector and (d loan of convection sector (2 supporting factors toward societies empowerment of economical sector in Klaten are: (a strategic area (b having closed emotional between the manager of BMT “Surya” and their clients, (c developing relatieves atmosphere event it’s still prioriting the professionalism (3 constraint factors toward societies empowerment of economical sector in Klaten are: (a They have only local network (b there is a clients who get stuck in the process of pay in installments (c pay in installments which is not appropriate with the loan.

  10. Household food access and child malnutrition: results from the eight-country MAL-ED study.

    Science.gov (United States)

    Psaki, Stephanie; Bhutta, Zulfiqar A; Ahmed, Tahmeed; Ahmed, Shamsir; Bessong, Pascal; Islam, Munirul; John, Sushil; Kosek, Margaret; Lima, Aldo; Nesamvuni, Cebisa; Shrestha, Prakash; Svensen, Erling; McGrath, Monica; Richard, Stephanie; Seidman, Jessica; Caulfield, Laura; Miller, Mark; Checkley, William

    2012-12-13

    Stunting results from decreased food intake, poor diet quality, and a high burden of early childhood infections, and contributes to significant morbidity and mortality worldwide. Although food insecurity is an important determinant of child nutrition, including stunting, development of universal measures has been challenging due to cumbersome nutritional questionnaires and concerns about lack of comparability across populations. We investigate the relationship between household food access, one component of food security, and indicators of nutritional status in early childhood across eight country sites. We administered a socioeconomic survey to 800 households in research sites in eight countries, including a recently validated nine-item food access insecurity questionnaire, and obtained anthropometric measurements from children aged 24 to 60 months. We used multivariable regression models to assess the relationship between household food access insecurity and anthropometry in children, and we assessed the invariance of that relationship across country sites. Average age of study children was 41 months. Mean food access insecurity score (range: 0-27) was 5.8, and varied from 2.4 in Nepal to 8.3 in Pakistan. Across sites, the prevalence of stunting (42%) was much higher than the prevalence of wasting (6%). In pooled regression analyses, a 10-point increase in food access insecurity score was associated with a 0.20 SD decrease in height-for-age Z score (95% CI 0.05 to 0.34 SD; p = 0.008). A likelihood ratio test for heterogeneity revealed that this relationship was consistent across countries (p = 0.17). Our study provides evidence of the validity of using a simple household food access insecurity score to investigate the etiology of childhood growth faltering across diverse geographic settings. Such a measure could be used to direct interventions by identifying children at risk of illness and death related to malnutrition.

  11. "Fotografický pohled malíře Jana Vochoče

    Czech Academy of Sciences Publication Activity Database

    Suchomelová, Marcela

    2005-01-01

    Roč. 5, č. 1 (2005), s. 49-53. ISBN 80-86712-30-3. ISSN 1213-399X Institutional research plan: CEZ:AV0Z90580513 Keywords : Portrait Photography of the Region * Privat Family Correspondence * Painter Jan Vochoč (1865-1920) Subject RIV: AC - Archeology, Anthropology, Ethnology

  12. The Earth in energy troubles; La Planete en mal d'energie

    Energy Technology Data Exchange (ETDEWEB)

    Pierret, Ch; Carroue, L; Goodchild, M F; Charvet, J P; Simon, A; Ane, J M; Auburtin, E; Barre, B; Bonin, S; Fumey, G; Daviet, S; Goupil, Ph; Helfer, M; Raison, J; Velut, S; Vidal, D; Radvanyi, J; Tapia, St de; Pourtier, R; Sebille-Lopez, Ph; Clairet, S; Poirson, A C; Guillaume, J; Collignon, B; Bauquis, P R; Brunel, S; Guillaume, J; Hourcade, B; Marchand-Vaguet, Y; Pitte, J R; Marchand-Vaguet, Y; Laherrere, J; Letourneau, M; Lemarchand, N; Beltran, A; Bret, B; Feckoua, L; Helfer, M; Lacoste, R; Manzagol, C; Tessier, F; Vanneph, A; Claessens, M; Berdevet, M; Tabeaud, M; Laherrere, J; Arnould, P; Berque, A; Brucher, W; Deshaies, M; Douguedroit, A; Husson, J P; Lemartinel, J; Mancebo, F; Baron-Yelles, N; Pitte, J R; Sede Marceau, J.H. de; Vigneau, J P; Tabeaud, M; Fremont, A; Crozet, Y; Maupu, J L; Orfeuil, J P; Savy, M; Viel, D; Hammer, A; Sanjuan, Th; Lagarec, D; Raillon, F; Koninck, R de; Bailly, A; Bruneau, M; Boulanger, Ph; Bret, B; Fournet-Guerin, C; Hourcade, J Ch; Pitte, J R; Sanjuan, Th; Verdeil, E; Butler, S de; Saint Germain, F; Bouette, N; Detot, A; Caracchioli, Ph; Bouette, N; Smaghue, N; Pousin, J; Buysse, Ph; Riallant, Y; Durand, H; Genter, A; Dieulin, C; Pronier, O; Badea, A; Tetart, F; Genevois, S; Leobet, M; Angsthelm, B; Calugaru, C; Domergue, Ph; Iacu, C; Muntele, L; Goodchild, M F; Costa, P

    2007-07-01

    This document gathers the available presentations (articles and transparencies) given at this annual meeting, the 2007 topic of which was the technological, geopolitical, economical, environmental, societal and development stakes of energy. 1 - technological stakes - which energies for the future: new energies, illusion or solution of the future; the Lorraine region, an energy land: strategies and stakes for a sustainable development; from China to Brazil: understanding the nuclear energy revival; hydroelectric power: renewable and sustainable energy; renewable energies and environment protection: the contribution of biofuels; wind power in Germany between success and contestation; 2 - geopolitical stakes - energy levier of power: the Gulf of Guinea hydrocarbons: between development and geopolitics; the complex evaluation of resources and reserves between technology, market and geopolitics; the new Bakou-Tbilissi-Ceyhan pipeline: what impacts for Turkey and the European Union; 3 - economical stakes - are public energy policies possible: the pro-alcohol program in Brazil; the surprising development of coal in the 21. century; natural gas: geo-economical and geopolitical stakes; exploitation of offshore platforms in Newfoundland: the new future of codfish island; tar sands of Alberta: promises and stakes of a 'Northern Arabia'; 4 - environmental stakes - energies responsible for the global warming: energy transformation and work in human societies; lessons learnt from the pre-industrial era: the limits of modern renewable energy sources; the energy policies in Europe: environmental constraints and geopolitical risks; reducing our energy consumption: a stake of the future; global warming and energy troubles; a territorial approach of energy, an answer to the 21. century challenges; the climate in an energy consuming world, debate and precautions; the Kyoto protocol through the geographical critics; 5 - society stakes - what energies for tomorrow's city: global design of transportation systems in Freiburg im Brisgau city (Germany); 6 - development stakes - access to energy; fatality or inequality: the energy appetite of China, between development and geopolitics; energy and health; wood fuel: the real energy crisis of the poorest southern countries; Madagascar: the lack of energy as a break to development; the challenges of the Three Gorges dam in China; geopolitics and electric power in Middle East and Lebanon; 7 - pedagogical courses: geography teaching using the map library of the French documentation; harvesting and criticizing the energy information coming from Internet; the Earth's energy troubles; petroleum in Africa, revealer of a development problem; petroleum, geopolitical stake of the present day world; the Penly nuclear power plant (Normandy, France); hydroelectric power in the Durance basin: some complex spatial stakes; wind power and land planning; the Earth's petroleum troubles; how petroleum fluxes can reveal the organization of worldwide trades; Picardie: a region in front of renewable energies; 8 - geomatics: wind farms and landscape; geothermal energy: potentialities, challenges and perspectives; Spot Image's projects of monitoring of hydrocarbon pollutions; geo-referenced databases for the agricultural and environmental management of Romania; virtual globes or educative geographical information systems: what is new for geography teaching; geo-portals: a scientific and technical tool; conflicts and petroleum, the Darfour example; the coal from Oltenie mining area (Romania): solution or puzzling problem; energy and society, which transportation policy; geo-history of petroleum in Romania; Citizens as sensors: the world of volunteered geography; the natural environment of the Danube delta. (J.S.)

  13. Household food access and child malnutrition: results from the eight-country MAL-ED study

    Directory of Open Access Journals (Sweden)

    Psaki Stephanie

    2012-12-01

    Full Text Available Abstract Background Stunting results from decreased food intake, poor diet quality, and a high burden of early childhood infections, and contributes to significant morbidity and mortality worldwide. Although food insecurity is an important determinant of child nutrition, including stunting, development of universal measures has been challenging due to cumbersome nutritional questionnaires and concerns about lack of comparability across populations. We investigate the relationship between household food access, one component of food security, and indicators of nutritional status in early childhood across eight country sites. Methods We administered a socioeconomic survey to 800 households in research sites in eight countries, including a recently validated nine-item food access insecurity questionnaire, and obtained anthropometric measurements from children aged 24 to 60 months. We used multivariable regression models to assess the relationship between household food access insecurity and anthropometry in children, and we assessed the invariance of that relationship across country sites. Results Average age of study children was 41 months. Mean food access insecurity score (range: 0–27 was 5.8, and varied from 2.4 in Nepal to 8.3 in Pakistan. Across sites, the prevalence of stunting (42% was much higher than the prevalence of wasting (6%. In pooled regression analyses, a 10-point increase in food access insecurity score was associated with a 0.20 SD decrease in height-for-age Z score (95% CI 0.05 to 0.34 SD; p = 0.008. A likelihood ratio test for heterogeneity revealed that this relationship was consistent across countries (p = 0.17. Conclusions Our study provides evidence of the validity of using a simple household food access insecurity score to investigate the etiology of childhood growth faltering across diverse geographic settings. Such a measure could be used to direct interventions by identifying children at risk of illness and death related to malnutrition.

  14. El "añadido" castellano del TJ 1 o las mal llamadas "prosiflcaciones"

    Directory of Open Access Journals (Sweden)

    Montoya Martínez, Jesús

    2002-06-01

    Full Text Available The author suggests to give the name of "addition" to the first twenty-five Cantigas de Santa María, written in prose, of the Ms TJ l. The author thinks that these additions do not come neither from Alfonso X nor from his surrouindings. They should have been added when the cultural reader was different and did not know the language of Galice. What proves this is the fact that the person who wrote this "addition" obtained information from another sources in some miracles (numbers 2 and 3 and those of praise are a theological gloss.

    El autor propone que se llame "añadido" a las hasta ahora denominadas prosificaciones castellans de las primeras veinticinco cantigas de Santa María del Ms TJ l. Él entiende que no se deben a Alfonso X, ni a su entorno. Que debieren ser añadidas en un tiempo en que el lector cultural era distinto y desconocía el gallego. Esto lo demuestra en cuanto el responsable del tal "añadido" acude a fuentes distintas en algunos milagros (números 2 y 3 y las de loor son una glosa teológica.

  15. PERAN BAITUL MAL WA TAMWIL (BMT TAQWA MUHAMMADIYAH DALAM MEMBEBASKAN MASYARAKAT DARI RENTENIR DI KOTA PADANG

    Directory of Open Access Journals (Sweden)

    Rozalinda Rozalinda

    2013-12-01

    Full Text Available This research was intended to know any factors that influence people using usurer and how did the BMT Taqwa Muhammadiyah helped people free from usurer in Padang. This research applying descriptive qualitative technique. The finding of this research showed that people were still using usurer in overcoming their financial problems due to (1 emergency need on business assistances, (2 quick process, simple procedure and shortherm paybak periode, (3 lack of bank and non bank access (4 they do not have any information of existing BMT, (5 depleted concern on religious believe on leaving excessive interest. Moreover the finding also found that BMT Taqwa Muhammadiyah had not yet provided significant financial assistance toward vendors.

  16. The Earth in energy troubles; La Planete en mal d'energie

    Energy Technology Data Exchange (ETDEWEB)

    Pierret, Ch.; Carroue, L.; Goodchild, M.F.; Charvet, J.P.; Simon, A.; Ane, J.M.; Auburtin, E.; Barre, B.; Bonin, S.; Fumey, G.; Daviet, S.; Goupil, Ph.; Helfer, M.; Raison, J.; Velut, S.; Vidal, D.; Radvanyi, J.; Tapia, St. de; Pourtier, R.; Sebille-Lopez, Ph.; Clairet, S.; Poirson, A.C.; Guillaume, J.; Collignon, B.; Bauquis, P.R.; Brunel, S.; Guillaume, J.; Hourcade, B.; Marchand-Vaguet, Y.; Pitte, J.R.; Marchand-Vaguet, Y.; Laherrere, J.; Letourneau, M.; Lemarchand, N.; Beltran, A.; Bret, B.; Feckoua, L.; Helfer, M.; Lacoste, R.; Manzagol, C.; Tessier, F.; Vanneph, A.; Claessens, M.; Berdevet, M.; Tabeaud, M.; Laherrere, J.; Arnould, P.; Berque, A.; Brucher, W.; Deshaies, M.; Douguedroit, A.; Husson, J.P.; Lemartinel, J.; Mancebo, F.; Baron-Yelles, N.; Pitte, J.R.; Sede Marceau, J.H. de; Vigneau, J.P.; Tabeaud, M.; Fremont, A.; Crozet, Y.; Maupu, J.L.; Orfeuil, J.P.; Savy, M.; Viel, D.; Hammer, A.; Sanjuan, Th.; Lagarec, D.; Raillon, F.; Koninck, R. de; Bailly, A.; Bruneau, M.; Boulanger, Ph.; Bret, B.; Fournet-Guerin, C.; Hourcade, J.Ch.; Pitte, J.R.; Sanjuan, Th.; Verdeil, E.; Butler, S. de; Saint Germain, F.; Bouette, N.; Detot, A.; Caracchioli, Ph.; Bouette, N.; Smaghue, N.; Pousin, J.; Buysse, Ph.; Riallant, Y.; Durand, H.; Genter, A.; Dieulin, C.; Pronier, O.; Badea, A.; Tetart, F.; Genevois, S.; Leobet, M.; Angsthelm, B.; Calugaru, C.; Domergue, Ph.; Iacu, C.; Muntele, L.; Goodchild, M.F.; Costa, P

    2007-07-01

    This document gathers the available presentations (articles and transparencies) given at this annual meeting, the 2007 topic of which was the technological, geopolitical, economical, environmental, societal and development stakes of energy. 1 - technological stakes - which energies for the future: new energies, illusion or solution of the future; the Lorraine region, an energy land: strategies and stakes for a sustainable development; from China to Brazil: understanding the nuclear energy revival; hydroelectric power: renewable and sustainable energy; renewable energies and environment protection: the contribution of biofuels; wind power in Germany between success and contestation; 2 - geopolitical stakes - energy levier of power: the Gulf of Guinea hydrocarbons: between development and geopolitics; the complex evaluation of resources and reserves between technology, market and geopolitics; the new Bakou-Tbilissi-Ceyhan pipeline: what impacts for Turkey and the European Union; 3 - economical stakes - are public energy policies possible: the pro-alcohol program in Brazil; the surprising development of coal in the 21. century; natural gas: geo-economical and geopolitical stakes; exploitation of offshore platforms in Newfoundland: the new future of codfish island; tar sands of Alberta: promises and stakes of a 'Northern Arabia'; 4 - environmental stakes - energies responsible for the global warming: energy transformation and work in human societies; lessons learnt from the pre-industrial era: the limits of modern renewable energy sources; the energy policies in Europe: environmental constraints and geopolitical risks; reducing our energy consumption: a stake of the future; global warming and energy troubles; a territorial approach of energy, an answer to the 21. century challenges; the climate in an energy consuming world, debate and precautions; the Kyoto protocol through the geographical critics; 5 - society stakes - what energies for tomorrow's city: global design of transportation systems in Freiburg im Brisgau city (Germany); 6 - development stakes - access to energy; fatality or inequality: the energy appetite of China, between development and geopolitics; energy and health; wood fuel: the real energy crisis of the poorest southern countries; Madagascar: the lack of energy as a break to development; the challenges of the Three Gorges dam in China; geopolitics and electric power in Middle East and Lebanon; 7 - pedagogical courses: geography teaching using the map library of the French documentation; harvesting and criticizing the energy information coming from Internet; the Earth's energy troubles; petroleum in Africa, revealer of a development problem; petroleum, geopolitical stake of the present day world; the Penly nuclear power plant (Normandy, France); hydroelectric power in the Durance basin: some complex spatial stakes; wind power and land planning; the Earth's petroleum troubles; how petroleum fluxes can reveal the organization of worldwide trades; Picardie: a region in front of renewable energies; 8 - geomatics: wind farms and landscape; geothermal energy: potentialities, challenges and perspectives; Spot Image's projects of monitoring of hydrocarbon pollutions; geo-referenced databases for the agricultural and environmental management of Romania; virtual globes or educative geographical information systems: what is new for geography teaching; geo-portals: a scientific and technical tool; conflicts and petroleum, the Darfour example; the coal from Oltenie mining area (Romania): solution or puzzling problem; energy and society, which transportation policy; geo-history of petroleum in Romania; Citizens as sensors: the world of volunteered geography; the natural environment of the Danube delta. (J.S.)

  17. Olomoucký barokní malíř Dominik Mayer (1653-1715)

    Czech Academy of Sciences Publication Activity Database

    Dolejší, Kateřina; Mlčák, L.

    -, č. 298 (2009), s. 3-16 ISSN 1212-1134 R&D Projects: GA ČR GA408/03/0059 Institutional research plan: CEZ:AV0Z80330511 Keywords : Olomouc Baroque painting * Dominik Mayer (1653-1715) * St. Michael´s church * Mater Gravida Subject RIV: AL - Art, Architecture, Cultural Heritage

  18. Utshjonõi malõi, no pedant... / Sergei Maltsev, Mihhail Petrov

    Index Scriptorium Estoniae

    Maltsev, Sergei

    2001-01-01

    Vastukaja Sergei Issakovi retsensioonile "Jamõ i uhabõ "Revelskogo trakta" ajalehes "Vesti : Nedelja Pljus" Feb/16 lk. 24 Vladimir Illjashevitshi raamatust "Revelskii trakt : istorii o russkoi Pribaltike" : Tallinn, 2001

  19. Web-marketing mix 4S v malé organizaci

    OpenAIRE

    Uhlíř, Petr

    2011-01-01

    The goal of this thesis is to evaluate whether application of the model of marketing promotion in the Internet based on the concept of web-marketing mix 4S in a small organization, sales-oriented professional machines and equipment for carpentry, plumbing and metal fabrication shop can achieve synergy and formulated key performance indicators. To achieve this goal is necessary to identify and describe technologies, tools, procedures and processes based on literature and publications that are ...

  20. Identification of SLURP-1 as an epidermal neuromodulator explains the clinical phenotype of Mal de Meleda

    DEFF Research Database (Denmark)

    Chimienti, Fabrice; Hogg, Ronald C; Plantard, Laure

    2003-01-01

    alpha 7 nicotinic acetylcholine receptors that are present in keratinocytes. These results identify SLURP-1 as a secreted epidermal neuromodulator which is likely to be essential for both epidermal homeostasis and inhibition of TNF-alpha release by macrophages during wound healing. This explains both...